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Search of human proteins with 24119274
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24119274 voltage gated channel like 1 [Homo sapiens]
(1738 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24119274 voltage gated channel like 1 [Homo sapiens] 3485 0.0
gi|192807298 calcium channel, voltage-dependent, L type, alpha 1... 235 3e-61
gi|192807300 calcium channel, voltage-dependent, L type, alpha 1... 229 2e-59
gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D ... 229 2e-59
gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F... 225 3e-58
gi|193788538 calcium channel, voltage-dependent, L type, alpha 1... 224 6e-58
gi|38505290 voltage-dependent calcium channel alpha 1G subunit i... 224 6e-58
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i... 224 7e-58
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i... 224 7e-58
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i... 224 7e-58
gi|193788548 calcium channel, voltage-dependent, L type, alpha 1... 222 3e-57
gi|38505286 voltage-dependent calcium channel alpha 1G subunit i... 221 5e-57
gi|193788544 calcium channel, voltage-dependent, L type, alpha 1... 221 6e-57
gi|193788540 calcium channel, voltage-dependent, L type, alpha 1... 221 6e-57
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i... 221 6e-57
gi|193788534 calcium channel, voltage-dependent, L type, alpha 1... 219 1e-56
gi|193794830 calcium channel, voltage-dependent, L type, alpha 1... 219 1e-56
gi|193788730 calcium channel, voltage-dependent, L type, alpha 1... 218 3e-56
gi|193788542 calcium channel, voltage-dependent, L type, alpha 1... 218 3e-56
gi|193788536 calcium channel, voltage-dependent, L type, alpha 1... 218 3e-56
gi|193794828 calcium channel, voltage-dependent, L type, alpha 1... 218 3e-56
gi|193794832 calcium channel, voltage-dependent, L type, alpha 1... 218 5e-56
gi|193788532 calcium channel, voltage-dependent, L type, alpha 1... 216 2e-55
gi|193788530 calcium channel, voltage-dependent, L type, alpha 1... 216 2e-55
gi|193788526 calcium channel, voltage-dependent, L type, alpha 1... 216 2e-55
gi|120433602 calcium channel, voltage-dependent, L type, alpha 1... 215 3e-55
gi|193788724 calcium channel, voltage-dependent, L type, alpha 1... 213 2e-54
gi|193788720 calcium channel, voltage-dependent, L type, alpha 1... 213 2e-54
gi|193788528 calcium channel, voltage-dependent, L type, alpha 1... 213 2e-54
gi|193788732 calcium channel, voltage-dependent, L type, alpha 1... 212 3e-54
>gi|24119274 voltage gated channel like 1 [Homo sapiens]
Length = 1738
Score = 3485 bits (9037), Expect = 0.0
Identities = 1738/1738 (100%), Positives = 1738/1738 (100%)
Query: 1 MLKRKQSSRVEAQPVTDFGPDESLSDNADILWINKPWVHSLLRICAIISVISVCMNTPMT 60
MLKRKQSSRVEAQPVTDFGPDESLSDNADILWINKPWVHSLLRICAIISVISVCMNTPMT
Sbjct: 1 MLKRKQSSRVEAQPVTDFGPDESLSDNADILWINKPWVHSLLRICAIISVISVCMNTPMT 60
Query: 61 FEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWV 120
FEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWV
Sbjct: 61 FEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWV 120
Query: 121 SLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWS 180
SLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWS
Sbjct: 121 SLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWS 180
Query: 181 VSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCP 240
VSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCP
Sbjct: 181 VSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCP 240
Query: 241 PGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYF 300
PGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYF
Sbjct: 241 PGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYF 300
Query: 301 YFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQ 360
YFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQ
Sbjct: 301 YFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQ 360
Query: 361 LVAVDVNKPQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYL 420
LVAVDVNKPQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYL
Sbjct: 361 LVAVDVNKPQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYL 420
Query: 421 AEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFTYFQVL 480
AEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFTYFQVL
Sbjct: 421 AEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFTYFQVL 480
Query: 481 RVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDRFTTF 540
RVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDRFTTF
Sbjct: 481 RVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDRFTTF 540
Query: 541 PRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVAVILD 600
PRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVAVILD
Sbjct: 541 PRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVAVILD 600
Query: 601 NLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQMVKISKLPSDFTVPKIRE 660
NLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQMVKISKLPSDFTVPKIRE
Sbjct: 601 NLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQMVKISKLPSDFTVPKIRE 660
Query: 661 SFMKQFIDRQQQDTCCLLRSLPTTSSSSCDHSKRSAIEDNKYIDQKLRKSVFSIRARNLL 720
SFMKQFIDRQQQDTCCLLRSLPTTSSSSCDHSKRSAIEDNKYIDQKLRKSVFSIRARNLL
Sbjct: 661 SFMKQFIDRQQQDTCCLLRSLPTTSSSSCDHSKRSAIEDNKYIDQKLRKSVFSIRARNLL 720
Query: 721 EKETAVTKILRACTRQRMLSGSFEGQPAKERSILSVQHHIRQERRSLRHGSNSQRISRGK 780
EKETAVTKILRACTRQRMLSGSFEGQPAKERSILSVQHHIRQERRSLRHGSNSQRISRGK
Sbjct: 721 EKETAVTKILRACTRQRMLSGSFEGQPAKERSILSVQHHIRQERRSLRHGSNSQRISRGK 780
Query: 781 SLETLTQDHSNTVRYRNAQREDSEIKMIQEKKEQAEMKRKVQEEELRENHPYFDKPLFIV 840
SLETLTQDHSNTVRYRNAQREDSEIKMIQEKKEQAEMKRKVQEEELRENHPYFDKPLFIV
Sbjct: 781 SLETLTQDHSNTVRYRNAQREDSEIKMIQEKKEQAEMKRKVQEEELRENHPYFDKPLFIV 840
Query: 841 GREHRFRNFCRVVVRARFNASKTDPVTGAVKNTKYHQLYDLLGLVTYLDWVMIIVTICSC 900
GREHRFRNFCRVVVRARFNASKTDPVTGAVKNTKYHQLYDLLGLVTYLDWVMIIVTICSC
Sbjct: 841 GREHRFRNFCRVVVRARFNASKTDPVTGAVKNTKYHQLYDLLGLVTYLDWVMIIVTICSC 900
Query: 901 ISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIF 960
ISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIF
Sbjct: 901 ISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIF 960
Query: 961 IYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLV 1020
IYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLV
Sbjct: 961 IYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLV 1020
Query: 1021 SILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEK 1080
SILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEK
Sbjct: 1021 SILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEK 1080
Query: 1081 KPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVGPIHGIYIHVFV 1140
KPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVGPIHGIYIHVFV
Sbjct: 1081 KPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVGPIHGIYIHVFV 1140
Query: 1141 FLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKSRLKIAQPLHLPPRPDNDGFR 1200
FLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKSRLKIAQPLHLPPRPDNDGFR
Sbjct: 1141 FLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKSRLKIAQPLHLPPRPDNDGFR 1200
Query: 1201 AKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKI 1260
AKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKI
Sbjct: 1201 AKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKI 1260
Query: 1261 IAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACVIVFRFFSICGKHVT 1320
IAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACVIVFRFFSICGKHVT
Sbjct: 1261 IAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACVIVFRFFSICGKHVT 1320
Query: 1321 LKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAIT 1380
LKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAIT
Sbjct: 1321 LKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAIT 1380
Query: 1381 VLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLN 1440
VLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLN
Sbjct: 1381 VLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLN 1440
Query: 1441 LLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGR 1500
LLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGR
Sbjct: 1441 LLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGR 1500
Query: 1501 LEVDLDKDKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLE 1560
LEVDLDKDKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLE
Sbjct: 1501 LEVDLDKDKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLE 1560
Query: 1561 YTIEEEVAKQTIRMWLKKCLKRIRAKQQQSCSIIHSLRESQQQELSRFLNPPSIETTQPS 1620
YTIEEEVAKQTIRMWLKKCLKRIRAKQQQSCSIIHSLRESQQQELSRFLNPPSIETTQPS
Sbjct: 1561 YTIEEEVAKQTIRMWLKKCLKRIRAKQQQSCSIIHSLRESQQQELSRFLNPPSIETTQPS 1620
Query: 1621 EDTNANSQDNSMQPETSSQQQLLSPTLSDRGGSRQDAADAGKPQRKFGQWRLPSAPKPIS 1680
EDTNANSQDNSMQPETSSQQQLLSPTLSDRGGSRQDAADAGKPQRKFGQWRLPSAPKPIS
Sbjct: 1621 EDTNANSQDNSMQPETSSQQQLLSPTLSDRGGSRQDAADAGKPQRKFGQWRLPSAPKPIS 1680
Query: 1681 HSVSSVNLRFGGRTTMKSVVCKMNPMTDAASCGSEVKKWWTRQLTVESDESGDDLLDI 1738
HSVSSVNLRFGGRTTMKSVVCKMNPMTDAASCGSEVKKWWTRQLTVESDESGDDLLDI
Sbjct: 1681 HSVSSVNLRFGGRTTMKSVVCKMNPMTDAASCGSEVKKWWTRQLTVESDESGDDLLDI 1738
>gi|192807298 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform c [Homo sapiens]
Length = 2137
Score = 235 bits (599), Expect = 3e-61
Identities = 204/749 (27%), Positives = 349/749 (46%), Gaps = 70/749 (9%)
Query: 856 ARFNASKTDPV-TGAVKNTKYHQLYDLLGLVTYLDWVMIIVTICSCISMMFESPFRRVMH 914
A F SKT+P+ G K +H +L+ ++ + S ++ E P R
Sbjct: 865 AFFILSKTNPIRVGCHKLINHHIFTNLI----------LVFIMLSSAALAAEDPIRSHSF 914
Query: 915 APT-LQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMP 973
T L +Y F ++E+ LK+ G F A R++ ++D+ + VSL+
Sbjct: 915 RNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQS 974
Query: 974 QNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFAS 1033
+ S ++L VLR LRPLR ++ VV+ +F + I + I+ L +FA
Sbjct: 975 SAI---SVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFAC 1031
Query: 1034 FGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANP 1093
GVQLF GK +C D E+C G+F + + G+ R+W N
Sbjct: 1032 IGVQLFKGKFYRCTDEAKSNPEECRGLF-----------ILYKDGDVDSPVVRERIWQN- 1079
Query: 1094 RNFNFDNVGNAMLALFEVLSLKGW----VEVRDVIIHRVGPIH------GIYIHVFVFLG 1143
+FNFDNV +AM+ALF V + +GW + D +GPI+ I+ +++ +
Sbjct: 1080 SDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIV 1139
Query: 1144 CMIGLTLFVGVVIANFNE--NKGTALLTVDQRRWEDLKSRLKIAQPL--HLPPRPDNDGF 1199
+ +FVG VI F E K +D+ + + ++ LK A+PL ++P P F
Sbjct: 1140 AFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALK-ARPLRRYIPKNPYQYKF 1198
Query: 1200 RAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMK 1259
Y + PF L++L L ++ + +++VFT +F +E+ +K
Sbjct: 1199 ---WYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLK 1255
Query: 1260 IIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFA----LLNAYTYMMGACVIVFRFFSIC 1315
+IA P G++ N +D L+ ++ V L A N + V R +
Sbjct: 1256 VIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMRLVKLL 1315
Query: 1316 GKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGEN--INRHANFS 1373
+ ++ LL T + S ++ + + +L YA G+ +FG V +N INR+ NF
Sbjct: 1316 SRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQ 1375
Query: 1374 SAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTP-------DEFTYWATDCGNYAGALMY 1426
+ +A+ +LFR TGE W +IM C+ C P +E+T CG+ A++Y
Sbjct: 1376 TFPQAVLLLFRCATGEAWQEIMLACL-PGKLCDPESDYNPGEEYT-----CGSNF-AIVY 1428
Query: 1427 FCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIP 1486
F SFY++ A++++NL VA+I++NF Y T + +L + L F+ IW+ D + +G I
Sbjct: 1429 FISFYMLCAFLIINLFVAVIMDNFD--YLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIK 1486
Query: 1487 TFRVKFLLRLLRGRLEV-DLDKDKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVDIR 1545
V LLR ++ L L ++ K + L++ G V F+ L L ++ I+
Sbjct: 1487 HLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIK 1546
Query: 1546 KSLQLEELLAREQLEYTIEEEVAKQTIRM 1574
LE+ A E+L I++ K ++++
Sbjct: 1547 TEGNLEQ--ANEELRAVIKKIWKKTSMKL 1573
Score = 139 bits (350), Expect = 2e-32
Identities = 141/665 (21%), Positives = 285/665 (42%), Gaps = 106/665 (15%)
Query: 79 MFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVF----EIADIVD 134
+ ++T E K+ G++ ++YV++ W + D +V S++L+ E +
Sbjct: 169 LIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSS 228
Query: 135 QMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGI 194
S ++ R ++R R+ + + +I+K + +++ +LF +++Y I
Sbjct: 229 GKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAM-VPLLHIALLVLFVIIIYAI 287
Query: 195 LGVQMF-GTFTYHC------VVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMD 247
+G+++F G C +V + P ++ T E G+ P G
Sbjct: 288 IGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNG----- 342
Query: 248 LEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIF 307
G + F+ ++ TV++ + EGW ++Y D+ + YF++L+
Sbjct: 343 -----------GITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVI 391
Query: 308 FLAWLVKNVFIAVIIETF------AEIRVQFQQM---------------W---------- 336
F ++ V N+ + V+ F A+ R FQ++ W
Sbjct: 392 FGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPE 451
Query: 337 --------GSRSSTTSTATTQMFH-EDAAG--------GWQLVAVDVNKPQGR------- 372
G R+++ T+ T+ + E+ +G G A+ +K R
Sbjct: 452 NEEEGGEEGKRNTSMPTSETESVNTENVSGEGENRGCCGSLCQAISKSKLSRRWRRWNRF 511
Query: 373 -APACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDL 431
C + ++S F+ ++ +V ++ + +S +Y ++ Q + +A LF
Sbjct: 512 NRRRC-RAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQD--IANKVLLALFTC 568
Query: 432 EALLKIWCLGFTGYISSSLHKFELLLVIG-------TTLHVYPDLYHSQFTYFQVLRVVR 484
E L+K++ LG Y S ++F+ +V G L + L S F ++LR+ +
Sbjct: 569 EMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFK 628
Query: 485 LIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR-------F 537
+ + +L + V + K + SL++ +I+ S + +Q+F D F
Sbjct: 629 VTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTF 688
Query: 538 TTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP--VVAIYFILYHLFATLILLSLFV 595
FP+A +++FQILT E W VM + A G + +V IYFI+ + ILL++F+
Sbjct: 689 DNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFL 748
Query: 596 AVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQMVKISKLPSDFTV 655
A+ +DNL D + L ++ EA ++K+ + + K N+P++ +I+ + T+
Sbjct: 749 AIAVDNL---ADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTI 805
Query: 656 PKIRE 660
RE
Sbjct: 806 DDYRE 810
Score = 100 bits (250), Expect = 9e-21
Identities = 87/336 (25%), Positives = 148/336 (44%), Gaps = 34/336 (10%)
Query: 889 DWVMIIVTICSCISMMFESPFRRVMHAPT---LQIAEYVFVIFMSIELNLKIMADGLFFT 945
D +++ +C+++ PF T L+ EY F+I ++E LKI+A GL
Sbjct: 129 DIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLH 188
Query: 946 PTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESG-----------AQLLMVLRCLRPL 994
P A +R+ ++D I +V L + E G + L R LRPL
Sbjct: 189 PNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPL 248
Query: 995 RIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKC---NDPNI 1051
R+ VP ++ V+ + + +++L+L +++++A G++LF GK+ K D +I
Sbjct: 249 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDI 308
Query: 1052 IRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEV 1111
+ ED + S N G + W V N NFDN AML +F+
Sbjct: 309 VAEED-----PAPCAFSGNGRQCTANGTECRSGW---VGPNGGITNFDNFAFAMLTVFQC 360
Query: 1112 LSLKGWVEVRDVIIHRVG-PIHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTV 1170
++++GW +V + +G + +Y V G L L +GV+ F++ + A
Sbjct: 361 ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG 420
Query: 1171 D-------QRRWEDLKSRLK-IAQPLHLPPRPDNDG 1198
D Q+ EDLK L I Q + P + +G
Sbjct: 421 DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEG 456
Score = 100 bits (249), Expect = 1e-20
Identities = 119/569 (20%), Positives = 234/569 (41%), Gaps = 90/569 (15%)
Query: 81 LYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWG 140
++T E++ KM G ++ ++ + + D +V VS +Q I+
Sbjct: 929 IFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAIS---------- 978
Query: 141 MLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF 200
+++I R L ++R R R + + + + + I ++ I ++ +GVQ+F
Sbjct: 979 VVKILRVLRVLRPLRAINRAKGLK-HVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLF 1037
Query: 201 GTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGY 260
Y C + +PE G +K D++ + +
Sbjct: 1038 KGKFYRCT----------------DEAKSNPEECRGLFIL--YKDGDVDSPVVRERIWQN 1079
Query: 261 SGFN--EIGTSIFTVYEAASQEGWVFLMYRAIDSFP---------RWRSYFYFITLIFFL 309
S FN + +++ ++ ++ EGW L+Y+AIDS R +FI I +
Sbjct: 1080 SDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIV 1139
Query: 310 AWLVKNVFIAVIIETFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNK- 368
A+ + N+F+ +I TF E G + ++ + L A + +
Sbjct: 1140 AFFMMNIFVGFVIVTFQE--------QGEKEYKNCELDK---NQRQCVEYALKARPLRRY 1188
Query: 369 -PQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTV 427
P+ ++ SS F + ++ ++ + A +Y E + D + + FT
Sbjct: 1189 IPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHY--EQSKMFNDAMDILNMVFTG 1246
Query: 428 LFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLHVY-------PDLYHSQFTYFQVL 480
+F +E +LK+ GY S + + F+ L+VIG+ + V + T+F++
Sbjct: 1247 VFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLF 1306
Query: 481 RVVRLIKI---SPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR- 536
RV+RL+K+ + ++ + L + + A L + + I +QMF V D
Sbjct: 1307 RVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNN 1366
Query: 537 -------FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP---------------V 574
F TFP+A + +F+ T E W ++M L G + P
Sbjct: 1367 QINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLP--GKLCDPESDYNPGEEYTCGSNF 1424
Query: 575 VAIYFILYHLFATLILLSLFVAVILDNLE 603
+YFI +++ ++++LFVAVI+DN +
Sbjct: 1425 AIVYFISFYMLCAFLIINLFVAVIMDNFD 1453
Score = 82.4 bits (202), Expect = 3e-15
Identities = 60/258 (23%), Positives = 124/258 (48%), Gaps = 24/258 (9%)
Query: 1200 RAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMK 1259
RA + +T F+ I L+ L + S ++ D +T + V +F E+ +K
Sbjct: 517 RAAVKSVT---FYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVK 573
Query: 1260 IIAMSPAGFWQSRRNRYDLLVTSLGVVWVVL-HFALLNAYTYMMGACVIVFRFFSICGKH 1318
+ ++ ++ S NR+D V G+ +L +++ + CV + R F +
Sbjct: 574 MYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHW 633
Query: 1319 VTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFG-TVKYGENINRHANFSSAGK 1377
+L L+ +++ SM +++ +FL ++ ++ G+ LFG + E + + F + +
Sbjct: 634 TSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQ 693
Query: 1378 AITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVII--- 1434
A+ +F+I+TGEDWN +M+D ++ G + + M C +++I+
Sbjct: 694 ALLTVFQILTGEDWNAVMYDGIMA---------------YGGPSSSGMIVCIYFIILFIC 738
Query: 1435 -AYIMLNLLVAIIVENFS 1451
YI+LN+ +AI V+N +
Sbjct: 739 GNYILLNVFLAIAVDNLA 756
Score = 55.8 bits (133), Expect = 3e-07
Identities = 69/330 (20%), Positives = 139/330 (42%), Gaps = 76/330 (23%)
Query: 379 KMMRSSVFHMFILSMVTVD-VIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKI 437
K++ +F IL + + +AA + + +FR ++ + AFT +F +E LLK+
Sbjct: 881 KLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYF--DYAFTAIFTVEILLKM 938
Query: 438 WCLGFTGYISSSLHK-------FELL--LVIGTTLHVYPDLYHSQFTYFQVLRVVRL--- 485
G + LHK F LL LV+G +L V + S + ++LRV+R+
Sbjct: 939 TTFG------AFLHKGAFCRNYFNLLDMLVVGVSL-VSFGIQSSAISVVKILRVLRVLRP 991
Query: 486 ---IKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF-------------- 528
I + L+ V +F + +G++++ T L + + I +Q+F
Sbjct: 992 LRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSN 1051
Query: 529 ------CFVEELD------------------RFTTFPRAFMSMFQILTQEGWVDVMDQTL 564
F+ D F A M++F + T EGW ++ + +
Sbjct: 1052 PEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAI 1111
Query: 565 NAVGHMWAPV------VAIYFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSE 618
++ G P+ ++I+FI+Y + ++++FV ++ + + K+ K E
Sbjct: 1112 DSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGE----KEYKNCE 1167
Query: 619 ANADTKE--KLPLRLRIFEKF-PNRPQMVK 645
+ + ++ + L+ R ++ P P K
Sbjct: 1168 LDKNQRQCVEYALKARPLRRYIPKNPYQYK 1197
Score = 53.9 bits (128), Expect = 1e-06
Identities = 68/316 (21%), Positives = 125/316 (39%), Gaps = 62/316 (19%)
Query: 890 WVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
W++I++ + +++ E + IA V + + E+ +K+ + GL ++
Sbjct: 527 WLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSL 586
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLV---PQMRKV 1006
F D F+ + + + + G + V RC+R LRIFK+ + +
Sbjct: 587 FNRF----DCFVVCGGITETILVELEIMSPLG---ISVFRCVRLLRIFKVTRHWTSLSNL 639
Query: 1007 VRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVS 1066
V L + K I + +LL +++F+ G+QLF GK F + +
Sbjct: 640 VASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGK------------------FNFDET 681
Query: 1067 VSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVR-DVII 1125
+K FDN A+L +F++L+ + W V D I+
Sbjct: 682 QTK-------------------------RSTFDNFPQALLTVFQILTGEDWNAVMYDGIM 716
Query: 1126 HRVGP-----IHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKS 1180
GP I IY + G I L +F+ + + N + + L Q+ + K
Sbjct: 717 AYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES---LNTAQKEEAEEKE 773
Query: 1181 RLKIAQPLHLPPRPDN 1196
R KIA+ L + +N
Sbjct: 774 RKKIARKESLENKKNN 789
Score = 49.7 bits (117), Expect = 2e-05
Identities = 62/288 (21%), Positives = 123/288 (42%), Gaps = 70/288 (24%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDT---LLMFLYTAEMIAKMHIRGIVKGDSSYVKD 105
++ V +NT ++ EHY ++T D +L+ L+T EM+ KM+ G+ +Y
Sbjct: 530 IVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGL----QAYFVS 585
Query: 106 RWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRT 165
+ FD F+V +L EI MSP G + + R + ++R F++ +
Sbjct: 586 LFNRFDCFVVCGGITETILVELEI------MSPLG-ISVFRCVRLLRIFKVTRHWTSLSN 638
Query: 166 RITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF-GTFTYHCVVNDTKPGNVTWNSLAI 224
+ ++L S + I S+ + L F++++ +LG+Q+F G F + ++T+ T+++
Sbjct: 639 LVASLLN-SMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNF----DETQTKRSTFDNFP- 692
Query: 225 PDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVF 284
++ TV++ + E W
Sbjct: 693 -------------------------------------------QALLTVFQILTGEDWNA 709
Query: 285 LMYRAIDSFPRWRS-----YFYFITLIFFLAWLVKNVFIAVIIETFAE 327
+MY I ++ S YFI L +++ NVF+A+ ++ A+
Sbjct: 710 VMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLAD 757
Score = 43.1 bits (100), Expect = 0.002
Identities = 58/286 (20%), Positives = 107/286 (37%), Gaps = 57/286 (19%)
Query: 51 ISVCMNTP-MTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCV 109
+ + +NT + +HY + +D L M ++T +M ++ I Y D W
Sbjct: 1213 VLIMLNTLCLAMQHYEQSKMFNDAMDILNM-VFTGVFTVEMVLKVIAFKPKGYFSDAWNT 1271
Query: 110 FDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITN 169
FD +V + + L + ++ +++S + R ++R ++ R E RT +
Sbjct: 1272 FDSLIVIGSIIDVALSEADNSEESNRIS----ITFFRLFRVMRLVKLLSRGEGIRTLLWT 1327
Query: 170 ILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDT-- 227
+K S + + V++ + +Y ++G+QMFG + D N N P
Sbjct: 1328 FIK-SFQALPYVALLIAMLFFIYAVIGMQMFG----KVAMRDNNQINRNNNFQTFPQAVL 1382
Query: 228 ---HCSPELEEGYQ-----CPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQ 279
C+ E +Q C PG C D + S F
Sbjct: 1383 LLFRCA--TGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNF---------------- 1424
Query: 280 EGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETF 325
+ YFI+ A+L+ N+F+AVI++ F
Sbjct: 1425 ------------------AIVYFISFYMLCAFLIINLFVAVIMDNF 1452
Score = 36.2 bits (82), Expect = 0.29
Identities = 58/315 (18%), Positives = 112/315 (35%), Gaps = 75/315 (23%)
Query: 1196 NDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSV----KWDVEDPVTVPLATMSVVFTFI 1251
N+ R I + F I L + A V L++ D + L + F I
Sbjct: 112 NNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLII 171
Query: 1252 FVLEVTMKIIA----MSPAGFWQSRRNRYDLLVTSLGVVWVVLHFALL-----NAYTYMM 1302
F +E +KIIA + P + ++ N D ++ +G+ V+L N +
Sbjct: 172 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231
Query: 1303 GACVI-------VFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVV 1355
G + V R + +L+++L +++ +M I + + +++ YA G+
Sbjct: 232 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291
Query: 1356 LF------------------------------------GTVKYGENINRHA---NFSSAG 1376
LF GT + + NF +
Sbjct: 292 LFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFA 351
Query: 1377 KAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAY 1436
A+ +F+ +T E W ++ YW D + +YF S + ++
Sbjct: 352 FAMLTVFQCITMEGWTDVL----------------YWMNDAMGFELPWVYFVSLVIFGSF 395
Query: 1437 IMLNLLVAIIVENFS 1451
+LNL++ ++ FS
Sbjct: 396 FVLNLVLGVLSGEFS 410
>gi|192807300 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform b [Homo sapiens]
Length = 2161
Score = 229 bits (584), Expect = 2e-59
Identities = 204/764 (26%), Positives = 349/764 (45%), Gaps = 85/764 (11%)
Query: 856 ARFNASKTDPV-TGAVKNTKYHQLYDLLGLVTYLDWVMIIVTICSCISMMFESPFRRVMH 914
A F SKT+P+ G K +H +L+ ++ + S ++ E P R
Sbjct: 865 AFFILSKTNPIRVGCHKLINHHIFTNLI----------LVFIMLSSAALAAEDPIRSHSF 914
Query: 915 APT-LQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMP 973
T L +Y F ++E+ LK+ G F A R++ ++D+ + VSL+
Sbjct: 915 RNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQS 974
Query: 974 QNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFAS 1033
+ S ++L VLR LRPLR ++ VV+ +F + I + I+ L +FA
Sbjct: 975 SAI---SVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFAC 1031
Query: 1034 FGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANP 1093
GVQLF GK +C D E+C G+F + + G+ R+W N
Sbjct: 1032 IGVQLFKGKFYRCTDEAKSNPEECRGLF-----------ILYKDGDVDSPVVRERIWQN- 1079
Query: 1094 RNFNFDNVGNAMLALFEVLSLKGW----VEVRDVIIHRVGPIH------GIYIHVFVFLG 1143
+FNFDNV +AM+ALF V + +GW + D +GPI+ I+ +++ +
Sbjct: 1080 SDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIV 1139
Query: 1144 CMIGLTLFVGVVIANFNE--NKGTALLTVDQRRWEDLKSRLKIAQPL--HLPPRPDNDGF 1199
+ +FVG VI F E K +D+ + + ++ LK A+PL ++P P F
Sbjct: 1140 AFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALK-ARPLRRYIPKNPYQYKF 1198
Query: 1200 RAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMK 1259
Y + PF L++L L ++ + +++VFT +F +E+ +K
Sbjct: 1199 ---WYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLK 1255
Query: 1260 IIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFA-------------------LLNAYTY 1300
+IA P G++ N +D L+ ++ V L A N +
Sbjct: 1256 VIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISI 1315
Query: 1301 MMGACVIVFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTV 1360
V R + + ++ LL T + S ++ + + +L YA G+ +FG V
Sbjct: 1316 TFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKV 1375
Query: 1361 KYGEN--INRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTP-------DEFT 1411
+N INR+ NF + +A+ +LFR TGE W +IM C+ C P +E+T
Sbjct: 1376 AMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACL-PGKLCDPESDYNPGEEYT 1434
Query: 1412 YWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQ 1471
CG+ A++YF SFY++ A++++NL VA+I++NF Y T + +L + L F+
Sbjct: 1435 -----CGSNF-AIVYFISFYMLCAFLIINLFVAVIMDNFD--YLTRDWSILGPHHLDEFK 1486
Query: 1472 IIWNMVDDKREGVIPTFRVKFLLRLLRGRLEV-DLDKDKLLFKHMCYEMERLHNGGDVTF 1530
IW+ D + +G I V LLR ++ L L ++ K + L++ G V F
Sbjct: 1487 RIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMF 1546
Query: 1531 HDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEEEVAKQTIRM 1574
+ L L ++ I+ LE+ A E+L I++ K ++++
Sbjct: 1547 NATLFALVRTALKIKTEGNLEQ--ANEELRAVIKKIWKKTSMKL 1588
Score = 139 bits (350), Expect = 2e-32
Identities = 141/665 (21%), Positives = 285/665 (42%), Gaps = 106/665 (15%)
Query: 79 MFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVF----EIADIVD 134
+ ++T E K+ G++ ++YV++ W + D +V S++L+ E +
Sbjct: 169 LIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSS 228
Query: 135 QMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGI 194
S ++ R ++R R+ + + +I+K + +++ +LF +++Y I
Sbjct: 229 GKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAM-VPLLHIALLVLFVIIIYAI 287
Query: 195 LGVQMF-GTFTYHC------VVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMD 247
+G+++F G C +V + P ++ T E G+ P G
Sbjct: 288 IGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNG----- 342
Query: 248 LEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIF 307
G + F+ ++ TV++ + EGW ++Y D+ + YF++L+
Sbjct: 343 -----------GITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVI 391
Query: 308 FLAWLVKNVFIAVIIETF------AEIRVQFQQM---------------W---------- 336
F ++ V N+ + V+ F A+ R FQ++ W
Sbjct: 392 FGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPE 451
Query: 337 --------GSRSSTTSTATTQMFH-EDAAG--------GWQLVAVDVNKPQGR------- 372
G R+++ T+ T+ + E+ +G G A+ +K R
Sbjct: 452 NEEEGGEEGKRNTSMPTSETESVNTENVSGEGENRGCCGSLCQAISKSKLSRRWRRWNRF 511
Query: 373 -APACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDL 431
C + ++S F+ ++ +V ++ + +S +Y ++ Q + +A LF
Sbjct: 512 NRRRC-RAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQD--IANKVLLALFTC 568
Query: 432 EALLKIWCLGFTGYISSSLHKFELLLVIG-------TTLHVYPDLYHSQFTYFQVLRVVR 484
E L+K++ LG Y S ++F+ +V G L + L S F ++LR+ +
Sbjct: 569 EMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFK 628
Query: 485 LIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR-------F 537
+ + +L + V + K + SL++ +I+ S + +Q+F D F
Sbjct: 629 VTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTF 688
Query: 538 TTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP--VVAIYFILYHLFATLILLSLFV 595
FP+A +++FQILT E W VM + A G + +V IYFI+ + ILL++F+
Sbjct: 689 DNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFL 748
Query: 596 AVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQMVKISKLPSDFTV 655
A+ +DNL D + L ++ EA ++K+ + + K N+P++ +I+ + T+
Sbjct: 749 AIAVDNL---ADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTI 805
Query: 656 PKIRE 660
RE
Sbjct: 806 DDYRE 810
Score = 100 bits (250), Expect = 9e-21
Identities = 87/336 (25%), Positives = 148/336 (44%), Gaps = 34/336 (10%)
Query: 889 DWVMIIVTICSCISMMFESPFRRVMHAPT---LQIAEYVFVIFMSIELNLKIMADGLFFT 945
D +++ +C+++ PF T L+ EY F+I ++E LKI+A GL
Sbjct: 129 DIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLH 188
Query: 946 PTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESG-----------AQLLMVLRCLRPL 994
P A +R+ ++D I +V L + E G + L R LRPL
Sbjct: 189 PNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPL 248
Query: 995 RIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKC---NDPNI 1051
R+ VP ++ V+ + + +++L+L +++++A G++LF GK+ K D +I
Sbjct: 249 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDI 308
Query: 1052 IRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEV 1111
+ ED + S N G + W V N NFDN AML +F+
Sbjct: 309 VAEED-----PAPCAFSGNGRQCTANGTECRSGW---VGPNGGITNFDNFAFAMLTVFQC 360
Query: 1112 LSLKGWVEVRDVIIHRVG-PIHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTV 1170
++++GW +V + +G + +Y V G L L +GV+ F++ + A
Sbjct: 361 ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG 420
Query: 1171 D-------QRRWEDLKSRLK-IAQPLHLPPRPDNDG 1198
D Q+ EDLK L I Q + P + +G
Sbjct: 421 DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEG 456
Score = 94.7 bits (234), Expect = 7e-19
Identities = 119/584 (20%), Positives = 234/584 (40%), Gaps = 105/584 (17%)
Query: 81 LYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWG 140
++T E++ KM G ++ ++ + + D +V VS +Q I+
Sbjct: 929 IFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAIS---------- 978
Query: 141 MLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF 200
+++I R L ++R R R + + + + + I ++ I ++ +GVQ+F
Sbjct: 979 VVKILRVLRVLRPLRAINRAKGLK-HVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLF 1037
Query: 201 GTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGY 260
Y C + +PE G +K D++ + +
Sbjct: 1038 KGKFYRCT----------------DEAKSNPEECRGLFIL--YKDGDVDSPVVRERIWQN 1079
Query: 261 SGFN--EIGTSIFTVYEAASQEGWVFLMYRAIDSFP---------RWRSYFYFITLIFFL 309
S FN + +++ ++ ++ EGW L+Y+AIDS R +FI I +
Sbjct: 1080 SDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIV 1139
Query: 310 AWLVKNVFIAVIIETFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNK- 368
A+ + N+F+ +I TF E G + ++ + L A + +
Sbjct: 1140 AFFMMNIFVGFVIVTFQE--------QGEKEYKNCELDK---NQRQCVEYALKARPLRRY 1188
Query: 369 -PQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTV 427
P+ ++ SS F + ++ ++ + A +Y E + D + + FT
Sbjct: 1189 IPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHY--EQSKMFNDAMDILNMVFTG 1246
Query: 428 LFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLHVY--------------------- 466
+F +E +LK+ GY S + + F+ L+VIG+ + V
Sbjct: 1247 VFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGN 1306
Query: 467 -PDLYHSQFTYFQVLRVVRLIKI---SPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSA 522
+ T+F++ RV+RL+K+ + ++ + L + + A L + +
Sbjct: 1307 SEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAV 1366
Query: 523 ISLQMFCFVEELDR--------FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP- 573
I +QMF V D F TFP+A + +F+ T E W ++M L G + P
Sbjct: 1367 IGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLP--GKLCDPE 1424
Query: 574 --------------VVAIYFILYHLFATLILLSLFVAVILDNLE 603
+YFI +++ ++++LFVAVI+DN +
Sbjct: 1425 SDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFD 1468
Score = 82.4 bits (202), Expect = 3e-15
Identities = 60/258 (23%), Positives = 124/258 (48%), Gaps = 24/258 (9%)
Query: 1200 RAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMK 1259
RA + +T F+ I L+ L + S ++ D +T + V +F E+ +K
Sbjct: 517 RAAVKSVT---FYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVK 573
Query: 1260 IIAMSPAGFWQSRRNRYDLLVTSLGVVWVVL-HFALLNAYTYMMGACVIVFRFFSICGKH 1318
+ ++ ++ S NR+D V G+ +L +++ + CV + R F +
Sbjct: 574 MYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHW 633
Query: 1319 VTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFG-TVKYGENINRHANFSSAGK 1377
+L L+ +++ SM +++ +FL ++ ++ G+ LFG + E + + F + +
Sbjct: 634 TSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQ 693
Query: 1378 AITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVII--- 1434
A+ +F+I+TGEDWN +M+D ++ G + + M C +++I+
Sbjct: 694 ALLTVFQILTGEDWNAVMYDGIMA---------------YGGPSSSGMIVCIYFIILFIC 738
Query: 1435 -AYIMLNLLVAIIVENFS 1451
YI+LN+ +AI V+N +
Sbjct: 739 GNYILLNVFLAIAVDNLA 756
Score = 55.8 bits (133), Expect = 3e-07
Identities = 69/330 (20%), Positives = 139/330 (42%), Gaps = 76/330 (23%)
Query: 379 KMMRSSVFHMFILSMVTVD-VIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKI 437
K++ +F IL + + +AA + + +FR ++ + AFT +F +E LLK+
Sbjct: 881 KLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYF--DYAFTAIFTVEILLKM 938
Query: 438 WCLGFTGYISSSLHK-------FELL--LVIGTTLHVYPDLYHSQFTYFQVLRVVRL--- 485
G + LHK F LL LV+G +L V + S + ++LRV+R+
Sbjct: 939 TTFG------AFLHKGAFCRNYFNLLDMLVVGVSL-VSFGIQSSAISVVKILRVLRVLRP 991
Query: 486 ---IKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF-------------- 528
I + L+ V +F + +G++++ T L + + I +Q+F
Sbjct: 992 LRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSN 1051
Query: 529 ------CFVEELD------------------RFTTFPRAFMSMFQILTQEGWVDVMDQTL 564
F+ D F A M++F + T EGW ++ + +
Sbjct: 1052 PEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAI 1111
Query: 565 NAVGHMWAPV------VAIYFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSE 618
++ G P+ ++I+FI+Y + ++++FV ++ + + K+ K E
Sbjct: 1112 DSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGE----KEYKNCE 1167
Query: 619 ANADTKE--KLPLRLRIFEKF-PNRPQMVK 645
+ + ++ + L+ R ++ P P K
Sbjct: 1168 LDKNQRQCVEYALKARPLRRYIPKNPYQYK 1197
Score = 53.9 bits (128), Expect = 1e-06
Identities = 68/316 (21%), Positives = 125/316 (39%), Gaps = 62/316 (19%)
Query: 890 WVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
W++I++ + +++ E + IA V + + E+ +K+ + GL ++
Sbjct: 527 WLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSL 586
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLV---PQMRKV 1006
F D F+ + + + + G + V RC+R LRIFK+ + +
Sbjct: 587 FNRF----DCFVVCGGITETILVELEIMSPLG---ISVFRCVRLLRIFKVTRHWTSLSNL 639
Query: 1007 VRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVS 1066
V L + K I + +LL +++F+ G+QLF GK F + +
Sbjct: 640 VASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGK------------------FNFDET 681
Query: 1067 VSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVR-DVII 1125
+K FDN A+L +F++L+ + W V D I+
Sbjct: 682 QTK-------------------------RSTFDNFPQALLTVFQILTGEDWNAVMYDGIM 716
Query: 1126 HRVGP-----IHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKS 1180
GP I IY + G I L +F+ + + N + + L Q+ + K
Sbjct: 717 AYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES---LNTAQKEEAEEKE 773
Query: 1181 RLKIAQPLHLPPRPDN 1196
R KIA+ L + +N
Sbjct: 774 RKKIARKESLENKKNN 789
Score = 49.7 bits (117), Expect = 2e-05
Identities = 62/288 (21%), Positives = 123/288 (42%), Gaps = 70/288 (24%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDT---LLMFLYTAEMIAKMHIRGIVKGDSSYVKD 105
++ V +NT ++ EHY ++T D +L+ L+T EM+ KM+ G+ +Y
Sbjct: 530 IVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGL----QAYFVS 585
Query: 106 RWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRT 165
+ FD F+V +L EI MSP G + + R + ++R F++ +
Sbjct: 586 LFNRFDCFVVCGGITETILVELEI------MSPLG-ISVFRCVRLLRIFKVTRHWTSLSN 638
Query: 166 RITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF-GTFTYHCVVNDTKPGNVTWNSLAI 224
+ ++L S + I S+ + L F++++ +LG+Q+F G F + ++T+ T+++
Sbjct: 639 LVASLLN-SMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNF----DETQTKRSTFDNFP- 692
Query: 225 PDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVF 284
++ TV++ + E W
Sbjct: 693 -------------------------------------------QALLTVFQILTGEDWNA 709
Query: 285 LMYRAIDSFPRWRS-----YFYFITLIFFLAWLVKNVFIAVIIETFAE 327
+MY I ++ S YFI L +++ NVF+A+ ++ A+
Sbjct: 710 VMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLAD 757
Score = 37.4 bits (85), Expect = 0.13
Identities = 58/297 (19%), Positives = 104/297 (35%), Gaps = 64/297 (21%)
Query: 51 ISVCMNTP-MTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCV 109
+ + +NT + +HY + +D L M ++T +M ++ I Y D W
Sbjct: 1213 VLIMLNTLCLAMQHYEQSKMFNDAMDILNM-VFTGVFTVEMVLKVIAFKPKGYFSDAWNT 1271
Query: 110 FDGFMVFCLWVSLVLQVFEIADIVDQMSPWGM-----------LRIPRPLIMIRAFRIYF 158
FD +V + + L + + + P + R ++R ++
Sbjct: 1272 FDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLS 1331
Query: 159 RFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVT 218
R E RT + +K S + + V++ + +Y ++G+QMFG + D N
Sbjct: 1332 RGEGIRTLLWTFIK-SFQALPYVALLIAMLFFIYAVIGMQMFG----KVAMRDNNQINRN 1386
Query: 219 WNSLAIPDT-----HCSPELEEGYQ-----CPPGFKCMDLEDLGLSRQELGYSGFNEIGT 268
N P C+ E +Q C PG C D + S F
Sbjct: 1387 NNFQTFPQAVLLLFRCA--TGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNF----- 1439
Query: 269 SIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETF 325
+ YFI+ A+L+ N+F+AVI++ F
Sbjct: 1440 -----------------------------AIVYFISFYMLCAFLIINLFVAVIMDNF 1467
Score = 36.2 bits (82), Expect = 0.29
Identities = 58/315 (18%), Positives = 112/315 (35%), Gaps = 75/315 (23%)
Query: 1196 NDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSV----KWDVEDPVTVPLATMSVVFTFI 1251
N+ R I + F I L + A V L++ D + L + F I
Sbjct: 112 NNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLII 171
Query: 1252 FVLEVTMKIIA----MSPAGFWQSRRNRYDLLVTSLGVVWVVLHFALL-----NAYTYMM 1302
F +E +KIIA + P + ++ N D ++ +G+ V+L N +
Sbjct: 172 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231
Query: 1303 GACVI-------VFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVV 1355
G + V R + +L+++L +++ +M I + + +++ YA G+
Sbjct: 232 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291
Query: 1356 LF------------------------------------GTVKYGENINRHA---NFSSAG 1376
LF GT + + NF +
Sbjct: 292 LFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFA 351
Query: 1377 KAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAY 1436
A+ +F+ +T E W ++ YW D + +YF S + ++
Sbjct: 352 FAMLTVFQCITMEGWTDVL----------------YWMNDAMGFELPWVYFVSLVIFGSF 395
Query: 1437 IMLNLLVAIIVENFS 1451
+LNL++ ++ FS
Sbjct: 396 FVLNLVLGVLSGEFS 410
>gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform a [Homo sapiens]
Length = 2181
Score = 229 bits (584), Expect = 2e-59
Identities = 204/764 (26%), Positives = 349/764 (45%), Gaps = 85/764 (11%)
Query: 856 ARFNASKTDPV-TGAVKNTKYHQLYDLLGLVTYLDWVMIIVTICSCISMMFESPFRRVMH 914
A F SKT+P+ G K +H +L+ ++ + S ++ E P R
Sbjct: 885 AFFILSKTNPIRVGCHKLINHHIFTNLI----------LVFIMLSSAALAAEDPIRSHSF 934
Query: 915 APT-LQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMP 973
T L +Y F ++E+ LK+ G F A R++ ++D+ + VSL+
Sbjct: 935 RNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQS 994
Query: 974 QNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFAS 1033
+ S ++L VLR LRPLR ++ VV+ +F + I + I+ L +FA
Sbjct: 995 SAI---SVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFAC 1051
Query: 1034 FGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANP 1093
GVQLF GK +C D E+C G+F + + G+ R+W N
Sbjct: 1052 IGVQLFKGKFYRCTDEAKSNPEECRGLF-----------ILYKDGDVDSPVVRERIWQN- 1099
Query: 1094 RNFNFDNVGNAMLALFEVLSLKGW----VEVRDVIIHRVGPIH------GIYIHVFVFLG 1143
+FNFDNV +AM+ALF V + +GW + D +GPI+ I+ +++ +
Sbjct: 1100 SDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIV 1159
Query: 1144 CMIGLTLFVGVVIANFNE--NKGTALLTVDQRRWEDLKSRLKIAQPL--HLPPRPDNDGF 1199
+ +FVG VI F E K +D+ + + ++ LK A+PL ++P P F
Sbjct: 1160 AFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALK-ARPLRRYIPKNPYQYKF 1218
Query: 1200 RAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMK 1259
Y + PF L++L L ++ + +++VFT +F +E+ +K
Sbjct: 1219 ---WYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLK 1275
Query: 1260 IIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFA-------------------LLNAYTY 1300
+IA P G++ N +D L+ ++ V L A N +
Sbjct: 1276 VIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISI 1335
Query: 1301 MMGACVIVFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTV 1360
V R + + ++ LL T + S ++ + + +L YA G+ +FG V
Sbjct: 1336 TFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKV 1395
Query: 1361 KYGEN--INRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTP-------DEFT 1411
+N INR+ NF + +A+ +LFR TGE W +IM C+ C P +E+T
Sbjct: 1396 AMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACL-PGKLCDPESDYNPGEEYT 1454
Query: 1412 YWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQ 1471
CG+ A++YF SFY++ A++++NL VA+I++NF Y T + +L + L F+
Sbjct: 1455 -----CGSNF-AIVYFISFYMLCAFLIINLFVAVIMDNFD--YLTRDWSILGPHHLDEFK 1506
Query: 1472 IIWNMVDDKREGVIPTFRVKFLLRLLRGRLEV-DLDKDKLLFKHMCYEMERLHNGGDVTF 1530
IW+ D + +G I V LLR ++ L L ++ K + L++ G V F
Sbjct: 1507 RIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMF 1566
Query: 1531 HDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEEEVAKQTIRM 1574
+ L L ++ I+ LE+ A E+L I++ K ++++
Sbjct: 1567 NATLFALVRTALKIKTEGNLEQ--ANEELRAVIKKIWKKTSMKL 1608
Score = 108 bits (269), Expect = 6e-23
Identities = 75/296 (25%), Positives = 144/296 (48%), Gaps = 21/296 (7%)
Query: 381 MRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCL 440
++S F+ ++ +V ++ + +S +Y ++ Q + +A LF E L+K++ L
Sbjct: 540 VKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQD--IANKVLLALFTCEMLVKMYSL 597
Query: 441 GFTGYISSSLHKFELLLVIG-------TTLHVYPDLYHSQFTYFQVLRVVRLIKISPALE 493
G Y S ++F+ +V G L + L S F ++LR+ ++ + +L
Sbjct: 598 GLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLS 657
Query: 494 DFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR-------FTTFPRAFMS 546
+ V + K + SL++ +I+ S + +Q+F D F FP+A ++
Sbjct: 658 NLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLT 717
Query: 547 MFQILTQEGWVDVMDQTLNAVGHMWAP--VVAIYFILYHLFATLILLSLFVAVILDNLEL 604
+FQILT E W VM + A G + +V IYFI+ + ILL++F+A+ +DNL
Sbjct: 718 VFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNL-- 775
Query: 605 DEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQMVKISKLPSDFTVPKIRE 660
D + L ++ EA ++K+ + + K N+P++ +I+ + T+ RE
Sbjct: 776 -ADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYRE 830
Score = 101 bits (252), Expect = 6e-21
Identities = 87/336 (25%), Positives = 148/336 (44%), Gaps = 34/336 (10%)
Query: 889 DWVMIIVTICSCISMMFESPFRRVMHAPT---LQIAEYVFVIFMSIELNLKIMADGLFFT 945
D +++ +C+++ PF T L+ EY F+I ++E LKI+A GL
Sbjct: 129 DIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLH 188
Query: 946 PTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESG-----------AQLLMVLRCLRPL 994
P A +R+ ++D I +V L + E G + L R LRPL
Sbjct: 189 PNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPL 248
Query: 995 RIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKC---NDPNI 1051
R+ VP ++ V+ + + +++L+L +++++A G++LF GK+ K D +I
Sbjct: 249 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDI 308
Query: 1052 IRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEV 1111
+ ED + S N G + W V N NFDN AML +F+
Sbjct: 309 VAEED-----PAPCAFSGNGRQCTANGTECRSGW---VGPNGGITNFDNFAFAMLTVFQC 360
Query: 1112 LSLKGWVEVRDVIIHRVG-PIHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTV 1170
++++GW +V + +G +Y + LG L L +GV+ F++ + A
Sbjct: 361 ITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARG 420
Query: 1171 D-------QRRWEDLKSRLK-IAQPLHLPPRPDNDG 1198
D Q+ EDLK L I Q + P + +G
Sbjct: 421 DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEG 456
Score = 94.7 bits (234), Expect = 7e-19
Identities = 119/584 (20%), Positives = 234/584 (40%), Gaps = 105/584 (17%)
Query: 81 LYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWG 140
++T E++ KM G ++ ++ + + D +V VS +Q I+
Sbjct: 949 IFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAIS---------- 998
Query: 141 MLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF 200
+++I R L ++R R R + + + + + I ++ I ++ +GVQ+F
Sbjct: 999 VVKILRVLRVLRPLRAINRAKGLK-HVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLF 1057
Query: 201 GTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGY 260
Y C + +PE G +K D++ + +
Sbjct: 1058 KGKFYRCT----------------DEAKSNPEECRGLFIL--YKDGDVDSPVVRERIWQN 1099
Query: 261 SGFN--EIGTSIFTVYEAASQEGWVFLMYRAIDSFP---------RWRSYFYFITLIFFL 309
S FN + +++ ++ ++ EGW L+Y+AIDS R +FI I +
Sbjct: 1100 SDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIV 1159
Query: 310 AWLVKNVFIAVIIETFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNK- 368
A+ + N+F+ +I TF E G + ++ + L A + +
Sbjct: 1160 AFFMMNIFVGFVIVTFQE--------QGEKEYKNCELDK---NQRQCVEYALKARPLRRY 1208
Query: 369 -PQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTV 427
P+ ++ SS F + ++ ++ + A +Y E + D + + FT
Sbjct: 1209 IPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHY--EQSKMFNDAMDILNMVFTG 1266
Query: 428 LFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLHVY--------------------- 466
+F +E +LK+ GY S + + F+ L+VIG+ + V
Sbjct: 1267 VFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGN 1326
Query: 467 -PDLYHSQFTYFQVLRVVRLIKI---SPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSA 522
+ T+F++ RV+RL+K+ + ++ + L + + A L + +
Sbjct: 1327 SEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAV 1386
Query: 523 ISLQMFCFVEELDR--------FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP- 573
I +QMF V D F TFP+A + +F+ T E W ++M L G + P
Sbjct: 1387 IGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLP--GKLCDPE 1444
Query: 574 --------------VVAIYFILYHLFATLILLSLFVAVILDNLE 603
+YFI +++ ++++LFVAVI+DN +
Sbjct: 1445 SDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFD 1488
Score = 87.0 bits (214), Expect = 1e-16
Identities = 66/285 (23%), Positives = 135/285 (47%), Gaps = 24/285 (8%)
Query: 1173 RRWEDLKSRLKIAQPLHLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWD 1232
RRW S+ K+++ R + RA + +T F+ I L+ L + S ++
Sbjct: 510 RRWGQAISKSKLSRRWRRWNRFNRRRCRAAVKSVT---FYWLVIVLVFLNTLTISSEHYN 566
Query: 1233 VEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVL-H 1291
D +T + V +F E+ +K+ ++ ++ S NR+D V G+ +L
Sbjct: 567 QPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVE 626
Query: 1292 FALLNAYTYMMGACVIVFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAF 1351
+++ + CV + R F + +L L+ +++ SM +++ +FL ++ ++
Sbjct: 627 LEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSL 686
Query: 1352 AGVVLFG-TVKYGENINRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEF 1410
G+ LFG + E + + F + +A+ +F+I+TGEDWN +M+D ++
Sbjct: 687 LGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMA--------- 737
Query: 1411 TYWATDCGNYAGALMYFCSFYVII----AYIMLNLLVAIIVENFS 1451
G + + M C +++I+ YI+LN+ +AI V+N +
Sbjct: 738 ------YGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLA 776
Score = 58.2 bits (139), Expect = 7e-08
Identities = 59/302 (19%), Positives = 126/302 (41%), Gaps = 34/302 (11%)
Query: 79 MFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVF----EIADIVD 134
+ ++T E K+ G++ ++YV++ W + D +V S++L+ E +
Sbjct: 169 LIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSS 228
Query: 135 QMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGI 194
S ++ R ++R R+ + + +I+K + +++ +LF +++Y I
Sbjct: 229 GKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAM-VPLLHIALLVLFVIIIYAI 287
Query: 195 LGVQMF-GTFTYHC------VVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMD 247
+G+++F G C +V + P ++ T E G+ P G
Sbjct: 288 IGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNG----- 342
Query: 248 LEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIF 307
G + F+ ++ TV++ + EGW ++Y D+ + YF++LI
Sbjct: 343 -----------GITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLII 391
Query: 308 FLAWLVKNVFIAVIIETFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAG--GWQLVAVD 365
++ V N+ + V+ F++ R + + +R Q ED G W A D
Sbjct: 392 LGSFFVLNLVLGVLSGEFSKEREKAK----ARGDFQKLREKQQLEEDLKGYLDWITQAED 447
Query: 366 VN 367
++
Sbjct: 448 ID 449
Score = 55.8 bits (133), Expect = 3e-07
Identities = 69/330 (20%), Positives = 139/330 (42%), Gaps = 76/330 (23%)
Query: 379 KMMRSSVFHMFILSMVTVD-VIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKI 437
K++ +F IL + + +AA + + +FR ++ + AFT +F +E LLK+
Sbjct: 901 KLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYF--DYAFTAIFTVEILLKM 958
Query: 438 WCLGFTGYISSSLHK-------FELL--LVIGTTLHVYPDLYHSQFTYFQVLRVVRL--- 485
G + LHK F LL LV+G +L V + S + ++LRV+R+
Sbjct: 959 TTFG------AFLHKGAFCRNYFNLLDMLVVGVSL-VSFGIQSSAISVVKILRVLRVLRP 1011
Query: 486 ---IKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF-------------- 528
I + L+ V +F + +G++++ T L + + I +Q+F
Sbjct: 1012 LRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSN 1071
Query: 529 ------CFVEELD------------------RFTTFPRAFMSMFQILTQEGWVDVMDQTL 564
F+ D F A M++F + T EGW ++ + +
Sbjct: 1072 PEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAI 1131
Query: 565 NAVGHMWAPV------VAIYFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSE 618
++ G P+ ++I+FI+Y + ++++FV ++ + + K+ K E
Sbjct: 1132 DSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGE----KEYKNCE 1187
Query: 619 ANADTKE--KLPLRLRIFEKF-PNRPQMVK 645
+ + ++ + L+ R ++ P P K
Sbjct: 1188 LDKNQRQCVEYALKARPLRRYIPKNPYQYK 1217
Score = 53.9 bits (128), Expect = 1e-06
Identities = 68/316 (21%), Positives = 125/316 (39%), Gaps = 62/316 (19%)
Query: 890 WVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
W++I++ + +++ E + IA V + + E+ +K+ + GL ++
Sbjct: 547 WLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSL 606
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLV---PQMRKV 1006
F D F+ + + + + G + V RC+R LRIFK+ + +
Sbjct: 607 FNRF----DCFVVCGGITETILVELEIMSPLG---ISVFRCVRLLRIFKVTRHWTSLSNL 659
Query: 1007 VRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVS 1066
V L + K I + +LL +++F+ G+QLF GK F + +
Sbjct: 660 VASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGK------------------FNFDET 701
Query: 1067 VSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVR-DVII 1125
+K FDN A+L +F++L+ + W V D I+
Sbjct: 702 QTK-------------------------RSTFDNFPQALLTVFQILTGEDWNAVMYDGIM 736
Query: 1126 HRVGP-----IHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKS 1180
GP I IY + G I L +F+ + + N + + L Q+ + K
Sbjct: 737 AYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES---LNTAQKEEAEEKE 793
Query: 1181 RLKIAQPLHLPPRPDN 1196
R KIA+ L + +N
Sbjct: 794 RKKIARKESLENKKNN 809
Score = 50.8 bits (120), Expect = 1e-05
Identities = 67/333 (20%), Positives = 124/333 (37%), Gaps = 81/333 (24%)
Query: 361 LVAVDVNKPQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNY-YKGENFRRQYDEFY 419
L + +N P RA C+ ++ F +FIL + + + A + ++
Sbjct: 106 LFCLSLNNPIRRA--CIS-IVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLE 162
Query: 420 LAEVAFTVLFDLEALLKIWCLGF----TGYISSSLHKFELLLVIGTTLHVYPDLY----- 470
E AF ++F +E LKI G Y+ + + + ++VI V +
Sbjct: 163 KVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETE 222
Query: 471 ---HSQ----------FTYFQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLL 517
HS F+VLR +RL+ P+L+ + I L + + ++
Sbjct: 223 GGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVI 282
Query: 518 IVMSAISLQMF-------CFVEELD----------------------------------- 535
I+ + I L++F CF + D
Sbjct: 283 IIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNG 342
Query: 536 ---RFTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLS 592
F F A +++FQ +T EGW DV+ +A+G W +YF+ + + +L+
Sbjct: 343 GITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWP---WVYFVSLIILGSFFVLN 399
Query: 593 LFVAVILDNLELDE-------DLKKLKQLKQSE 618
L + V+ + D +KL++ +Q E
Sbjct: 400 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLE 432
Score = 49.7 bits (117), Expect = 2e-05
Identities = 62/288 (21%), Positives = 123/288 (42%), Gaps = 70/288 (24%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDT---LLMFLYTAEMIAKMHIRGIVKGDSSYVKD 105
++ V +NT ++ EHY ++T D +L+ L+T EM+ KM+ G+ +Y
Sbjct: 550 IVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGL----QAYFVS 605
Query: 106 RWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRT 165
+ FD F+V +L EI MSP G + + R + ++R F++ +
Sbjct: 606 LFNRFDCFVVCGGITETILVELEI------MSPLG-ISVFRCVRLLRIFKVTRHWTSLSN 658
Query: 166 RITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF-GTFTYHCVVNDTKPGNVTWNSLAI 224
+ ++L S + I S+ + L F++++ +LG+Q+F G F + ++T+ T+++
Sbjct: 659 LVASLLN-SMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNF----DETQTKRSTFDNFP- 712
Query: 225 PDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVF 284
++ TV++ + E W
Sbjct: 713 -------------------------------------------QALLTVFQILTGEDWNA 729
Query: 285 LMYRAIDSFPRWRS-----YFYFITLIFFLAWLVKNVFIAVIIETFAE 327
+MY I ++ S YFI L +++ NVF+A+ ++ A+
Sbjct: 730 VMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLAD 777
Score = 37.4 bits (85), Expect = 0.13
Identities = 58/315 (18%), Positives = 113/315 (35%), Gaps = 75/315 (23%)
Query: 1196 NDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSV----KWDVEDPVTVPLATMSVVFTFI 1251
N+ R I + F I L + A V L++ D + L + F I
Sbjct: 112 NNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLII 171
Query: 1252 FVLEVTMKIIA----MSPAGFWQSRRNRYDLLVTSLGVVWVVLHFALL-----NAYTYMM 1302
F +E +KIIA + P + ++ N D ++ +G+ V+L N +
Sbjct: 172 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231
Query: 1303 GACVI-------VFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVV 1355
G + V R + +L+++L +++ +M I + + +++ YA G+
Sbjct: 232 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291
Query: 1356 LF------------------------------------GTVKYGENINRHA---NFSSAG 1376
LF GT + + NF +
Sbjct: 292 LFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFA 351
Query: 1377 KAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAY 1436
A+ +F+ +T E W ++ YW D + +YF S ++ ++
Sbjct: 352 FAMLTVFQCITMEGWTDVL----------------YWVNDAIGWEWPWVYFVSLIILGSF 395
Query: 1437 IMLNLLVAIIVENFS 1451
+LNL++ ++ FS
Sbjct: 396 FVLNLVLGVLSGEFS 410
Score = 37.4 bits (85), Expect = 0.13
Identities = 58/297 (19%), Positives = 104/297 (35%), Gaps = 64/297 (21%)
Query: 51 ISVCMNTP-MTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCV 109
+ + +NT + +HY + +D L M ++T +M ++ I Y D W
Sbjct: 1233 VLIMLNTLCLAMQHYEQSKMFNDAMDILNM-VFTGVFTVEMVLKVIAFKPKGYFSDAWNT 1291
Query: 110 FDGFMVFCLWVSLVLQVFEIADIVDQMSPWGM-----------LRIPRPLIMIRAFRIYF 158
FD +V + + L + + + P + R ++R ++
Sbjct: 1292 FDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLS 1351
Query: 159 RFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVT 218
R E RT + +K S + + V++ + +Y ++G+QMFG + D N
Sbjct: 1352 RGEGIRTLLWTFIK-SFQALPYVALLIAMLFFIYAVIGMQMFG----KVAMRDNNQINRN 1406
Query: 219 WNSLAIPDT-----HCSPELEEGYQ-----CPPGFKCMDLEDLGLSRQELGYSGFNEIGT 268
N P C+ E +Q C PG C D + S F
Sbjct: 1407 NNFQTFPQAVLLLFRCA--TGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNF----- 1459
Query: 269 SIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETF 325
+ YFI+ A+L+ N+F+AVI++ F
Sbjct: 1460 -----------------------------AIVYFISFYMLCAFLIINLFVAVIMDNF 1487
>gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F
subunit [Homo sapiens]
Length = 1977
Score = 225 bits (573), Expect = 3e-58
Identities = 218/842 (25%), Positives = 380/842 (45%), Gaps = 99/842 (11%)
Query: 785 LTQDHSNTVRYRNAQREDSEIKMIQEKKEQAEMKRKVQEEELRENHPYFDKPLFIVGREH 844
L Q++ V + E+ + + +E+ E + + +EEE E + +V +E
Sbjct: 782 LPQENEGLVPGVEKEEEEGARREGADMEEEEEEEEEEEEEEEEEGAGGVELLQEVVPKE- 840
Query: 845 RFRNFCRVVV----RARFNASKTDPVTGAVKNTKYHQLYDLLGLVTYLDWVMIIVTICSC 900
+VV A F S+T+P+ +H ++ L +++ I S
Sbjct: 841 ------KVVPIPEGSAFFCLSQTNPLRKGCHTLIHHHVFTNL---------ILVFIILSS 885
Query: 901 ISMMFESPFR-RVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDI 959
+S+ E P R L +Y F ++E+ LK+ G F + R + ++D+
Sbjct: 886 VSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDL 945
Query: 960 FIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFL 1019
+ VSLI + A S ++L VLR LRPLR ++ VV+ +F + I
Sbjct: 946 LVVSVSLISF---GIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGN 1002
Query: 1020 VSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGE 1079
+ I+ L +FA GVQLF GK C D ++C G F L G+
Sbjct: 1003 IMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSF-----------LVYPDGD 1051
Query: 1080 KKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGW----VEVRDVIIHRVGPIH--- 1132
R+W N +FNFDNV +AM+ALF V + +GW + D GPI+
Sbjct: 1052 VSRPLVRERLWVN-SDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYR 1110
Query: 1133 ---GIYIHVFVFLGCMIGLTLFVGVVIANFNE--NKGTALLTVDQRRWEDLKSRLKIAQP 1187
++ V++ + + +FVG VI F + +D+ + + ++ LK AQP
Sbjct: 1111 VEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALK-AQP 1169
Query: 1188 L--HLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVK-WDVEDPVTVPLATM 1244
L ++P P + +++ F+ + LL+L +V L+++ ++ P + +
Sbjct: 1170 LRRYIPKNP----HQYRVWATVNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDIL 1225
Query: 1245 SVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVL-------HFALLNA 1297
++VFT +F +E+ +KIIA P ++ N +D L+ +V + + H +
Sbjct: 1226 NMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSE 1285
Query: 1298 YTYMMGACVI----VFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAG 1353
+ + V R + K ++ LL T + S ++ + + ++ YA G
Sbjct: 1286 DSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIG 1345
Query: 1354 VVLFGTV--KYGENINRHANFSSAGKAITVLFRIVTGEDWNKIM------HDCMVQPPFC 1405
+ +FG V + G INR+ NF + +A+ +LFR TGE W +IM + C + F
Sbjct: 1346 MQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFG 1405
Query: 1406 TPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYN 1465
+EFT CG+ A+ YF SF+++ A++++NL VA+I++NF Y T + +L +
Sbjct: 1406 PGEEFT-----CGSNF-AIAYFISFFMLCAFLIINLFVAVIMDNFD--YLTRDWSILGPH 1457
Query: 1466 DLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEV-DLDKDKLLFKHMCYEMERLHN 1524
L F+ IW+ D +G I V LLR ++ L L ++ K + L++
Sbjct: 1458 HLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS 1517
Query: 1525 GGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEEEVAKQTIRMWLKKCLKRIR 1584
G VTF+ L L S+ I+ LE+ A Q +R+ +KK KR++
Sbjct: 1518 DGTVTFNATLFALVRTSLKIKTEGNLEQ---------------ANQELRIVIKKIWKRMK 1562
Query: 1585 AK 1586
K
Sbjct: 1563 QK 1564
Score = 99.8 bits (247), Expect = 2e-20
Identities = 133/617 (21%), Positives = 251/617 (40%), Gaps = 99/617 (16%)
Query: 40 SLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGD 99
+L+ + I+S +S+ P+ + ++ D ++T E++ KM + G
Sbjct: 875 NLILVFIILSSVSLAAEDPIRAHSFR--NHILGYFDYAFTSIFTVEILLKMTVFGAFLHR 932
Query: 100 SSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFR 159
S+ + + + D L VS+ L F I S +++I R L ++R R R
Sbjct: 933 GSFCRSWFNMLD-----LLVVSVSLISFGI-----HSSAISVVKILRVLRVLRPLRAINR 982
Query: 160 FELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTK--PGNV 217
+ + + + + I ++ I ++ +GVQ+F Y C ++ K P
Sbjct: 983 AKGLK-HVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCT-DEAKHTPQEC 1040
Query: 218 TWNSLAIPDTHCS-PELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEA 276
+ L PD S P + E F F+ + +++ ++
Sbjct: 1041 KGSFLVYPDGDVSRPLVRERLWVNSDFN------------------FDNVLSAMMALFTV 1082
Query: 277 ASQEGWVFLMYRAIDSFPRWRSYFY---------FITLIFFLAWLVKNVFIAVIIETFAE 327
++ EGW L+Y+AID++ Y FI I +A+ + N+F+ +I TF
Sbjct: 1083 STFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITF-- 1140
Query: 328 IRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVA-VDVNKPQGRAPACLQKMMRSSVF 386
R Q +Q + + + E A L + N Q R A + + +
Sbjct: 1141 -RAQGEQEY---QNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSA--AFEY 1194
Query: 387 HMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFTGYI 446
MF+L ++ V +A +Y + F D + + FT LF +E +LKI Y
Sbjct: 1195 LMFLLILLNT-VALAMQHYEQTAPFNYAMD---ILNMVFTGLFTIEMVLKIIAFKPKHYF 1250
Query: 447 SSSLHKFELLLVIGTTLHVY--------------PDLYHSQFTYFQVLRVVRLIKI---S 489
+ + + F+ L+V+G+ + + D T+F++ RV+RL+K+
Sbjct: 1251 TDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKG 1310
Query: 490 PALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELD--------RFTTFP 541
+ ++ + L + + A + + + I +QMF V D F TFP
Sbjct: 1311 EGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFP 1370
Query: 542 RAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP---------------VVAIYFILYHLFA 586
+A + +F+ T E W ++M +L G+ P YFI + +
Sbjct: 1371 QAVLLLFRCATGEAWQEIMLASLP--GNRCDPESDFGPGEEFTCGSNFAIAYFISFFMLC 1428
Query: 587 TLILLSLFVAVILDNLE 603
++++LFVAVI+DN +
Sbjct: 1429 AFLIINLFVAVIMDNFD 1445
Score = 98.2 bits (243), Expect = 6e-20
Identities = 71/241 (29%), Positives = 125/241 (51%), Gaps = 18/241 (7%)
Query: 378 QKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKI 437
++ ++S+ + +L +V ++ + AS ++ + Q E+ A LF +E LLK+
Sbjct: 523 RRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEY--ANKVLLCLFTVEMLLKL 580
Query: 438 WCLGFTGYISSSLHKFELLLVIGTTLHV-YPDLYHSQFTYFQVLRVVRLIKISP------ 490
+ LG + Y+SS ++F+ +V G L ++ Q VLR VRL++I
Sbjct: 581 YGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWA 640
Query: 491 ALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR-------FTTFPRA 543
+L + V + K + SL++ +I+ S + +Q+F D+ F TFP+A
Sbjct: 641 SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQA 700
Query: 544 FMSMFQILTQEGWVDVMDQTLNAVGHMWAP--VVAIYFILYHLFATLILLSLFVAVILDN 601
+++FQILT E W VM + A G + P +V IYFI+ + ILL++F+A+ +DN
Sbjct: 701 LLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 760
Query: 602 L 602
L
Sbjct: 761 L 761
Score = 90.5 bits (223), Expect = 1e-17
Identities = 91/357 (25%), Positives = 158/357 (44%), Gaps = 51/357 (14%)
Query: 885 VTYLDW----VMIIVTI-CSCISMMFESPF-----RRVMHAPTLQIAEYVFVIFMSIELN 934
++ ++W ++I++TI +C+++ PF H L+ EYVF++ ++E
Sbjct: 86 ISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANH--NLEQVEYVFLVIFTVETV 143
Query: 935 LKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCW-----MPQNVPAESG------AQ 983
LKI+A GL P+A IR+ ++D I +V L + P + P G +
Sbjct: 144 LKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVK 203
Query: 984 LLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKL 1043
L R LRPLR+ VP + V+ + + +++L+L +++++A G++LF G++
Sbjct: 204 ALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRM 263
Query: 1044 AKC---NDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRN--FNF 1098
K ++ ED + + LN G W P NF
Sbjct: 264 HKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGR----------WPGPNGGITNF 313
Query: 1099 DNVGNAMLALFEVLSLKGWVEVRDVIIHRVG-PIHGIYIHVFVFLGCMIGLTLFVGVVIA 1157
DN AML +F+ ++++GW +V + +G + +Y V G L L +GV+
Sbjct: 314 DNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSG 373
Query: 1158 NFNENKGTALLTVD-------QRRWEDLKSRLK-IAQPLHL----PPRPDNDGFRAK 1202
F++ + A D Q+ EDL+ L I Q L P DN G A+
Sbjct: 374 EFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWITQAEELDMEDPSADDNLGSMAE 430
Score = 80.9 bits (198), Expect = 1e-14
Identities = 129/655 (19%), Positives = 253/655 (38%), Gaps = 183/655 (27%)
Query: 77 LLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQM 136
+L+ L+T EM+ K++ G+ G S+YV + FD F+V +L+ + V M
Sbjct: 567 VLLCLFTVEMLLKLY--GL--GPSAYVSSFFNRFDCFVV----CGGILETTLVE--VGAM 616
Query: 137 SPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILG 196
P G + + R + ++R F++ + + ++L S + I S+ + L F++++ +LG
Sbjct: 617 QPLG-ISVLRCVRLLRIFKVTRHWASLSNLVASLLN-SMKSIASLLLLLFLFIIIFSLLG 674
Query: 197 VQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQ 256
+Q+FG TH
Sbjct: 675 MQLFG------------------GKFNFDQTHTKR------------------------- 691
Query: 257 ELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDS-----FPRWRSYFYFITLIFFLAW 311
S F+ ++ TV++ + E W +MY I + FP YFI L +
Sbjct: 692 ----STFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNY 747
Query: 312 LVKNVFIAVIIETFAE---------------------------IRVQFQQMWGSR----- 339
++ NVF+A+ ++ A V+ ++ G+R
Sbjct: 748 ILLNVFLAIAVDNLASGDAGTAKDKGGEKSNEKDLPQENEGLVPGVEKEEEEGARREGAD 807
Query: 340 ---SSTTSTATTQMFHEDAAGGWQLVAVDVNK------PQGRAPACL------QKMMRSS 384
+ E+ AGG +L+ V K P+G A CL +K +
Sbjct: 808 MEEEEEEEEEEEEEEEEEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTL 867
Query: 385 VFHMFILSMVTVDVIV-----AASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWC 439
+ H +++ V +I+ AA + + +FR ++ + AFT +F +E LLK+
Sbjct: 868 IHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYF--DYAFTSIFTVEILLKMTV 925
Query: 440 LG---FTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFTYFQVLRVVRL------IKISP 490
G G S LLV+ +L + ++ S + ++LRV+R+ I +
Sbjct: 926 FGAFLHRGSFCRSWFNMLDLLVVSVSLISF-GIHSSAISVVKILRVLRVLRPLRAINRAK 984
Query: 491 ALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF---------------------- 528
L+ V +F + +G++++ T L + + I +Q+F
Sbjct: 985 GLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSF 1044
Query: 529 ----------------CFVEELDRFTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWA 572
+V F A M++F + T EGW ++ + ++A
Sbjct: 1045 LVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHG 1104
Query: 573 PV------VAIYFILYHLFATLILLSLFVAVIL-----------DNLELDEDLKK 610
P+ ++++FI+Y + ++++FV ++ N ELD++ ++
Sbjct: 1105 PIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQ 1159
Score = 79.0 bits (193), Expect = 4e-14
Identities = 52/211 (24%), Positives = 104/211 (49%), Gaps = 21/211 (9%)
Query: 1247 VFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVL-HFALLNAYTYMMGAC 1305
V +F +E+ +K+ + P+ + S NR+D V G++ L + + C
Sbjct: 567 VLLCLFTVEMLLKLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRC 626
Query: 1306 VIVFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFG-TVKYGE 1364
V + R F + +L L+ +++ SM +++ +FL ++ ++ G+ LFG + +
Sbjct: 627 VRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQ 686
Query: 1365 NINRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQ--PPFCTPDEFTYWATDCGNYAG 1422
+ + F + +A+ +F+I+TGEDWN +M+D ++ PF + G
Sbjct: 687 THTKRSTFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPF---------------FPG 731
Query: 1423 AL--MYFCSFYVIIAYIMLNLLVAIIVENFS 1451
L +YF ++ YI+LN+ +AI V+N +
Sbjct: 732 MLVCIYFIILFICGNYILLNVFLAIAVDNLA 762
Score = 56.6 bits (135), Expect = 2e-07
Identities = 64/290 (22%), Positives = 116/290 (40%), Gaps = 66/290 (22%)
Query: 890 WVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
W ++++ + +++ E + V + A V + ++E+ LK+ G P+A
Sbjct: 533 WAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLG----PSAY 588
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQL---LMVLRCLRPLRIFKLV---PQM 1003
+ F D F+ ++ + E GA + VLRC+R LRIFK+ +
Sbjct: 589 VSSFFNRFDCFVVCGGIL------ETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASL 642
Query: 1004 RKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRI 1063
+V L + K I + +LL +++F+ G+QLF GK F
Sbjct: 643 SNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGK------------------FNF 684
Query: 1064 NVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGW-VEVRD 1122
+ + +K FD A+L +F++L+ + W V + D
Sbjct: 685 DQTHTK-------------------------RSTFDTFPQALLTVFQILTGEDWNVVMYD 719
Query: 1123 VIIHRVGPIHG-----IYIHVFVFLGCMIGLTLFVGVVIANF-NENKGTA 1166
I+ GP IY + G I L +F+ + + N + + GTA
Sbjct: 720 GIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDAGTA 769
Score = 52.0 bits (123), Expect = 5e-06
Identities = 59/302 (19%), Positives = 124/302 (41%), Gaps = 46/302 (15%)
Query: 74 LDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVF--EIAD 131
++ + + ++T E + K+ G+V S+Y+++ W + D +V S++L+ D
Sbjct: 130 VEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGD 189
Query: 132 IVDQMSPWGMLRIPRPLIMIRAFRIYFRFEL----PRTRIT-NILKRSGEQIWSVSIFLL 186
G + +RAFR+ L P I N + ++ + +++ +L
Sbjct: 190 APHTGGKPGGFDVKA----LRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVL 245
Query: 187 FFLLLYGILGVQMF-GTFTYHCVV--------NDTKP--GNVTWNSLAIPDTHCSPELEE 235
F +++Y I+G+++F G C D P + + + + T C
Sbjct: 246 FVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGR--- 302
Query: 236 GYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPR 295
+ P G G + F+ ++ TV++ + EGW ++Y D+
Sbjct: 303 -WPGPNG----------------GITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGY 345
Query: 296 WRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQMWGSRSSTTSTATTQMFHEDA 355
+ YF++L+ F ++ V N+ + V+ F++ R + + +R Q ED
Sbjct: 346 ELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAK----ARGDFQKQREKQQMEEDL 401
Query: 356 AG 357
G
Sbjct: 402 RG 403
Score = 42.0 bits (97), Expect = 0.005
Identities = 55/261 (21%), Positives = 102/261 (39%), Gaps = 76/261 (29%)
Query: 422 EVAFTVLFDLEALLKIWCLGF----TGYISSSLHKFELLLVIGTTLHVY--------PDL 469
E F V+F +E +LKI G + YI + + + ++V+ V D
Sbjct: 131 EYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDA 190
Query: 470 YHS----------QFTYFQVLRVVRLIKISPALE---DFVYKIFGPGKKLGSLVVFTASL 516
H+ F+VLR +RL+ P+L + + K P + LV+F +
Sbjct: 191 PHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLF---V 247
Query: 517 LIVMSAISLQMF-------CF-------VEE----------------------------- 533
+I+ + I L++F C+ EE
Sbjct: 248 IIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRWPGPN 307
Query: 534 --LDRFTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILL 591
+ F F A +++FQ +T EGW DV+ +A+G+ + +YF+ +F + +L
Sbjct: 308 GGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGY---ELPWVYFVSLVIFGSFFVL 364
Query: 592 SLFVAVILDNLELDEDLKKLK 612
+L + V+ + + K +
Sbjct: 365 NLVLGVLSGEFSKEREKAKAR 385
Score = 41.2 bits (95), Expect = 0.009
Identities = 60/302 (19%), Positives = 112/302 (37%), Gaps = 53/302 (17%)
Query: 33 INKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHI 92
+N L+ + +++ +++ M +E P Y L+ + L+T EM+ K+
Sbjct: 1187 VNSAAFEYLMFLLILLNTVALAMQH---YEQTAPFNYAMDILNMVFTGLFTIEMVLKI-- 1241
Query: 93 RGIVKGDSSYVKDRWCVFDGFMVFCLWVSL-VLQVFEIADIVDQMSPWGMLRIP--RPLI 149
I Y D W FD +V V + V +V + + + I R
Sbjct: 1242 --IAFKPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFR 1299
Query: 150 MIRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVV 209
++R ++ + E RT + +K S + + V++ + +Y ++G+QMFG
Sbjct: 1300 VMRLVKLLSKGEGIRTLLWTFIK-SFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGT 1358
Query: 210 NDTKPGNV-TWNSLAIPDTHCSPELEEGYQ-----CPPGFKCMDLEDLGLSRQELGYSGF 263
+ N T+ + C+ E +Q PG +C D G + S F
Sbjct: 1359 QINRNNNFQTFPQAVLLLFRCA--TGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNF 1416
Query: 264 NEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIE 323
+ YFI+ A+L+ N+F+AVI++
Sbjct: 1417 ----------------------------------AIAYFISFFMLCAFLIINLFVAVIMD 1442
Query: 324 TF 325
F
Sbjct: 1443 NF 1444
Score = 37.0 bits (84), Expect = 0.17
Identities = 58/311 (18%), Positives = 108/311 (34%), Gaps = 75/311 (24%)
Query: 1200 RAKMYDITQHPFFKRTIALLVLAQSVLLSV----KWDVEDPVTVPLATMSVVFTFIFVLE 1255
R I + F I L + A V L V D + L + VF IF +E
Sbjct: 82 RRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVE 141
Query: 1256 VTMKIIA----MSPAGFWQSRRNRYDLLVTSLGVVWVVLHFA------------LLNAYT 1299
+KI+A + P+ + ++ N D ++ +G+ V+L +
Sbjct: 142 TVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFD 201
Query: 1300 YMMGACVIVFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLF-- 1357
V R + +L ++L +++ ++ I + + +++ YA G+ LF
Sbjct: 202 VKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLG 261
Query: 1358 ---------GTVKYGENINRHANFSSAGKAITV--------------------------- 1381
G+ E S +G+A T+
Sbjct: 262 RMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAML 321
Query: 1382 -LFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLN 1440
+F+ VT E W ++ YW D Y +YF S + ++ +LN
Sbjct: 322 TVFQCVTMEGWTDVL----------------YWMQDAMGYELPWVYFVSLVIFGSFFVLN 365
Query: 1441 LLVAIIVENFS 1451
L++ ++ FS
Sbjct: 366 LVLGVLSGEFS 376
>gi|193788538 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 15 [Homo sapiens]
Length = 2138
Score = 224 bits (571), Expect = 6e-58
Identities = 191/712 (26%), Positives = 340/712 (47%), Gaps = 62/712 (8%)
Query: 891 VMIIVTICSCISMMFESPFRRV-MHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
+++ + S IS+ E P + L A+YVF ++E+ LK+ A G F +
Sbjct: 905 LILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSF 964
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRE 1009
R++ ++D+ + VSLI + ++L VLR LRPLR ++ VV+
Sbjct: 965 CRNYFNILDLLVVSVSLISFGIQSSAINV---VKILRVLRVLRPLRAINRAKGLKHVVQC 1021
Query: 1010 LFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSK 1069
+F + I + I+ L +FA GVQLF GKL C+D + +C G +
Sbjct: 1022 VFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNY-------- 1073
Query: 1070 NLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEV--RDVIIHR 1127
+ + GE PR W N + F+FDNV AM+ALF V + +GW E+ R + H
Sbjct: 1074 ---ITYKDGEVDHPIIQPRSWENSK-FDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHT 1129
Query: 1128 --VGPIH------GIYIHVFVFLGCMIGLTLFVGVVIANFNE--NKGTALLTVDQRRWED 1177
GPI+ I+ +++ + + +FVG VI F E + +D+ + +
Sbjct: 1130 EDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQC 1189
Query: 1178 LKSRLKIAQPL--HLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVK-WDVE 1234
++ LK A+PL ++P + + K++ + +F+ + +L+L ++ L+++ +
Sbjct: 1190 VEYALK-ARPLRRYIP----KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQS 1244
Query: 1235 DPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFAL 1294
+ + ++++FT +F +E+ +K+IA P G++ N +D L+ ++ V+L
Sbjct: 1245 CLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETN 1304
Query: 1295 LNAYTYMMGA---------CVIVFRFF------SICGKHVTLKMLLLTVVVSMYKSFFII 1339
+T + + FR F + + ++ LL T + S ++
Sbjct: 1305 PAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVA 1364
Query: 1340 VGMFLLLLCYAFAGVVLFGTVKYGE--NINRHANFSSAGKAITVLFRIVTGEDWNKIMHD 1397
+ + +L YA G+ +FG + + INR+ NF + +A+ +LFR TGE W IM
Sbjct: 1365 LLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLA 1424
Query: 1398 CMVQ---PPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFY 1454
CM P P T T CG+ + A+ YF SFY++ A++++NL VA+I++NF Y
Sbjct: 1425 CMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFD--Y 1481
Query: 1455 STEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEV-DLDKDKLLFK 1513
T + +L + L F+ IW D + +G I V LLR ++ L L ++ K
Sbjct: 1482 LTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACK 1541
Query: 1514 HMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEE 1565
+ L++ G V F+ L L ++ I+ LE+ A E+L I++
Sbjct: 1542 RLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQ--ANEELRAIIKK 1591
Score = 147 bits (370), Expect = 1e-34
Identities = 149/687 (21%), Positives = 296/687 (43%), Gaps = 102/687 (14%)
Query: 74 LDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIV 133
++ L + ++T E K+ G++ ++Y+++ W + D +V V L + E A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVV---VGLFSAILEQATKA 218
Query: 134 DQMSPWGMLRIPRPLIMIRAFRIYFRFEL----PRTRIT-NILKRSGEQIWSVSIFLLFF 188
D + G + +RAFR+ L P ++ N + ++ + +++ +LF
Sbjct: 219 DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 278
Query: 189 LLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDL 248
+++Y I+G+++F + N +V P C+ E G QC G C
Sbjct: 279 IIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSP---CALETGHGRQCQNGTVCKP- 334
Query: 249 EDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFF 308
G + G + F+ ++ TV++ + EGW ++Y D+ R + YF+TLI
Sbjct: 335 ---GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIII 391
Query: 309 LAWLVKNVFIAVIIETF------AEIRVQFQQM---------------WGSRS------- 340
++ V N+ + V+ F A+ R FQ++ W +++
Sbjct: 392 GSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPEN 451
Query: 341 -------------STTSTATTQMFHEDAAGG-------WQLVAVDVNKPQGRA------P 374
S ++ T + E+ AGG +A ++K +
Sbjct: 452 EDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNR 511
Query: 375 ACLQKM---MRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDL 431
C +K ++S+VF+ ++ +V ++ + AS +Y N+ + + A A LF
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD--TANKALLALFTA 569
Query: 432 EALLKIWCLGFTGYISSSLHKFELLLVIGTTLH-------VYPDLYHSQFTYFQVLRVVR 484
E LLK++ LG Y S ++F+ +V G L + L S ++LR+ +
Sbjct: 570 EMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFK 629
Query: 485 LIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR-------F 537
+ + +L + V + + + SL++ +I+ S + +Q+F D F
Sbjct: 630 ITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTF 689
Query: 538 TTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP--VVAIYFILYHLFATLILLSLFV 595
FP++ +++FQILT E W VM + A G P +V IYFI+ + ILL++F+
Sbjct: 690 DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFL 749
Query: 596 AVILDNLELDEDLKKLKQLKQSE---------ANADTKEKLPLRLRIFEKFPNRPQMVKI 646
A+ +DNL E L ++ ++ E A+ + K++L + + E ++ + +++
Sbjct: 750 AIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE---SKEEKIEL 806
Query: 647 SKLPSDFTVPKIRESFMKQFIDRQQQD 673
+ +D P + M + +D
Sbjct: 807 KSITADGESPPATKINMDDLQPNENED 833
Score = 104 bits (260), Expect = 7e-22
Identities = 94/357 (26%), Positives = 164/357 (45%), Gaps = 62/357 (17%)
Query: 885 VTYLDW----VMIIVTI-CSCISMMFESPFRRVMHAPT---LQIAEYVFVIFMSIELNLK 936
++ ++W ++I++TI +C+++ PF T L+ EY+F+I ++E LK
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 937 IMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQL-----------L 985
++A GL F P A +R+ ++D I +V L F + Q A+ L L
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGL-FSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 986 MVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAK 1045
R LRPLR+ VP ++ V+ + + +++L+L +++++A G++LF GK+ K
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 1046 C-------------NDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWAN 1092
+DP+ E +G N +V K PG W
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCK-------PG-----------WDG 338
Query: 1093 PRN--FNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVG-PIHGIYIHVFVFLGCMIGLT 1149
P++ NFDN AML +F+ ++++GW +V + VG IY + +G L
Sbjct: 339 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLN 398
Query: 1150 LFVGVVIANFNENKGTALLTVD-------QRRWEDLKSRLK-IAQPLHLPPRPDNDG 1198
L +GV+ F++ + A D Q+ EDLK L I Q + P +++G
Sbjct: 399 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEG 455
Score = 101 bits (251), Expect = 7e-21
Identities = 131/626 (20%), Positives = 259/626 (41%), Gaps = 97/626 (15%)
Query: 33 INKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHI 92
+N +L+ ++S IS+ P+ +H ++ D + ++T E+I KM
Sbjct: 897 VNDTIFTNLILFFILLSSISLAAEDPV--QHTSFRNHILGNADYVFTSIFTLEIILKMTA 954
Query: 93 RGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIR 152
G S+ ++ + + D L VS+ L F I Q S +++I R L ++R
Sbjct: 955 YGAFLHKGSFCRNYFNILD-----LLVVSVSLISFGI-----QSSAINVVKILRVLRVLR 1004
Query: 153 AFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDT 212
R R + + + + + I ++ I ++ +GVQ+F Y C + +
Sbjct: 1005 PLRAINRAKGLK-HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS-DSS 1062
Query: 213 KPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFT 272
K I T+ E++ P ++ + F+ + ++
Sbjct: 1063 KQTEAECKGNYI--TYKDGEVDHPIIQPRSWENSKFD-------------FDNVLAAMMA 1107
Query: 273 VYEAASQEGWVFLMYRAIDSFPRWRSYFY---------FITLIFFLAWLVKNVFIAVIIE 323
++ ++ EGW L+YR+IDS + Y FI I +A+ + N+F+ +I
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 324 TFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPACLQKMMRS 383
TF E Q +Q + + + + A + + P+ + + ++ S
Sbjct: 1168 TFQE---QGEQEYKNCELDKNQRQCVEYALKARPLRRYI------PKNQHQYKVWYVVNS 1218
Query: 384 SVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFT 443
+ F + ++ ++ I A +Y G++ + + + FT LF +E +LK+
Sbjct: 1219 TYFEYLMFVLILLNTICLAMQHY-GQSCLFKI-AMNILNMLFTGLFTVEMILKLIAFKPK 1276
Query: 444 GYISSSLHKFELLLVIGTTLHVY----PDLYHSQ--------------FTYFQVLRVVRL 485
GY S + F+ L+VIG+ + V H+Q T+F++ RV+RL
Sbjct: 1277 GYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRL 1336
Query: 486 IKI---SPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFV-----EELDR- 536
+K+ + ++ + L + + L + + I +Q+F + E++R
Sbjct: 1337 VKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRN 1396
Query: 537 --FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP-----------------VVAI 577
F TFP+A + +F+ T E W D+M + G AP
Sbjct: 1397 NNFQTFPQAVLLLFRCATGEAWQDIMLACM--PGKKCAPESEPSNSTEGETPCGSSFAVF 1454
Query: 578 YFILYHLFATLILLSLFVAVILDNLE 603
YFI +++ ++++LFVAVI+DN +
Sbjct: 1455 YFISFYMLCAFLIINLFVAVIMDNFD 1480
Score = 78.2 bits (191), Expect = 7e-14
Identities = 57/250 (22%), Positives = 122/250 (48%), Gaps = 17/250 (6%)
Query: 1206 ITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSP 1265
+ + F+ I L+ L + S ++ + +T T + +F E+ +K+ ++
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1266 AGFWQSRRNRYDLLVTSLGVVWVVL-HFALLNAYTYMMGACVIVFRFFSICGKHVTLKML 1324
++ S NR+D V G++ +L +++ + CV + R F I +L L
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1325 LLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFG-TVKYGENINRHANFSSAGKAITVLF 1383
+ +++ S+ +++ +FL ++ ++ G+ LFG + E R + F + +++ +F
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVF 700
Query: 1384 RIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGAL--MYFCSFYVIIAYIMLNL 1441
+I+TGEDWN +M+D ++ A ++ G L +YF ++ YI+LN+
Sbjct: 701 QILTGEDWNSVMYDGIM-------------AYGGPSFPGMLVCIYFIILFICGNYILLNV 747
Query: 1442 LVAIIVENFS 1451
+AI V+N +
Sbjct: 748 FLAIAVDNLA 757
Score = 58.9 bits (141), Expect = 4e-08
Identities = 68/287 (23%), Positives = 120/287 (41%), Gaps = 68/287 (23%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDTL---LMFLYTAEMIAKMHIRGIVKGDSSYVKD 105
+ V +NT + EHY ++T DT L+ L+TAEM+ KM+ G+ +Y
Sbjct: 531 IFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL----QAYFVS 586
Query: 106 RWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRT 165
+ FD F+V + +L +I MSP G + + R + ++R F+I R+ +
Sbjct: 587 LFNRFDCFVVCGGILETILVETKI------MSPLG-ISVLRCVRLLRIFKIT-RYWNSLS 638
Query: 166 RITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIP 225
+ L S I S+ + L F++++ +LG+Q+FG G ++ +
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFG-------------GKFNFDEM--- 682
Query: 226 DTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFL 285
+ S F+ S+ TV++ + E W +
Sbjct: 683 -------------------------------QTRRSTFDNFPQSLLTVFQILTGEDWNSV 711
Query: 286 MYRAI-----DSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAE 327
MY I SFP YFI L +++ NVF+A+ ++ A+
Sbjct: 712 MYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLAD 758
Score = 51.2 bits (121), Expect = 9e-06
Identities = 64/306 (20%), Positives = 120/306 (39%), Gaps = 62/306 (20%)
Query: 890 WVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
W++I + + +++ E + A + + E+ LK+ + GL ++
Sbjct: 528 WLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSL 587
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVP---QMRKV 1006
F D F+ ++ + + + G + VLRC+R LRIFK+ + +
Sbjct: 588 FNRF----DCFVVCGGILETILVETKIMSPLG---ISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1007 VRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVS 1066
V L + + I + +LL +++F+ G+QLF GK F +
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGK------------------FNFDE- 681
Query: 1067 VSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVR-DVII 1125
R FDN ++L +F++L+ + W V D I+
Sbjct: 682 ------------------------MQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIM 717
Query: 1126 HRVGP-----IHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKS 1180
GP + IY + G I L +F+ + + N + + LT Q+ E+ K
Sbjct: 718 AYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAES---LTSAQKEEEEEKE 774
Query: 1181 RLKIAQ 1186
R K+A+
Sbjct: 775 RKKLAR 780
Score = 48.9 bits (115), Expect = 4e-05
Identities = 57/275 (20%), Positives = 117/275 (42%), Gaps = 57/275 (20%)
Query: 379 KMMRSSVFHMFILSMVTVDVI-VAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKI 437
+++ ++F IL + + I +AA + + +FR A+ FT +F LE +LK+
Sbjct: 895 RIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHI--LGNADYVFTSIFTLEIILKM 952
Query: 438 WCLG---FTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFTYFQVLRVVRL------IKI 488
G G + LLV+ +L + + S ++LRV+R+ I
Sbjct: 953 TAYGAFLHKGSFCRNYFNILDLLVVSVSLISF-GIQSSAINVVKILRVLRVLRPLRAINR 1011
Query: 489 SPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF------CFVE---------- 532
+ L+ V +F + +G++V+ T L + + I +Q+F C
Sbjct: 1012 AKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKG 1071
Query: 533 --------ELDRFTTFPR--------------AFMSMFQILTQEGWVDVMDQTLNAVGHM 570
E+D PR A M++F + T EGW +++ +++++
Sbjct: 1072 NYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTED 1131
Query: 571 WAPV------VAIYFILYHLFATLILLSLFVAVIL 599
P+ ++I+FI+Y + ++++FV ++
Sbjct: 1132 KGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
Score = 41.6 bits (96), Expect = 0.007
Identities = 57/300 (19%), Positives = 110/300 (36%), Gaps = 76/300 (25%)
Query: 1212 FKRTIALLVLAQSVLLSV----KWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMS--- 1264
F+ I L + A V L++ D + L + +F IF +E +K+IA
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLF 185
Query: 1265 -PAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGA-----------CVIVFRFF 1312
P + ++ N D ++ +G+ +L A +G V R
Sbjct: 186 HPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPL 245
Query: 1313 SICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLF--------------- 1357
+ +L+++L +++ +M I + + +++ YA G+ LF
Sbjct: 246 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIA 305
Query: 1358 -----------------------GTV-KYGENINRHA--NFSSAGKAITVLFRIVTGEDW 1391
GTV K G + +H NF + A+ +F+ +T E W
Sbjct: 306 DVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGW 365
Query: 1392 NKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFS 1451
++ YW D +YF + +I ++ +LNL++ ++ FS
Sbjct: 366 TDVL----------------YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS 409
>gi|38505290 voltage-dependent calcium channel alpha 1G subunit
isoform 13 [Homo sapiens]
Length = 2243
Score = 224 bits (571), Expect = 6e-58
Identities = 263/1141 (23%), Positives = 482/1141 (42%), Gaps = 134/1141 (11%)
Query: 378 QKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKI 437
+K++ S F I+ + V+ + Y+ E + ++ + FT LF LE LLK+
Sbjct: 737 RKIVDSKYFGRGIMIAILVNTLSMGIEYH--EQPEELTNALEISNIVFTSLFALEMLLKL 794
Query: 438 WCLGFTGYISSSLHKFELLLVIGTTLHVYPDLYH--SQFTYFQVLRVVRLIKISPALEDF 495
G GYI + + F+ ++V+ + + S F+++RV++L++ PAL+
Sbjct: 795 LVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQ 854
Query: 496 VYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF-C-FVEELD--------RFTTFPRAFM 545
+ + + + + + + S + + +F C F E D F + A +
Sbjct: 855 LVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIV 914
Query: 546 SMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVAVILDNLELD 605
++FQILTQE W V+ + + WA A+YFI F +L +L VA++++ + +
Sbjct: 915 TVFQILTQEDWNKVLYNGMASTSS-WA---ALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Query: 606 EDLKKLKQ---LKQSEANADTKEKLPLRLRIFEKFPNR------PQMVKISKLPSDFTVP 656
D K + + D K L L + P P ++ + P ++P
Sbjct: 971 GDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATP--MSLP 1028
Query: 657 KIRESFMKQFIDRQQQDTCCLLRSLPTT--------SSSSCDHSKRSAIEDNKYIDQKLR 708
K + + + + + T + P S+ S HS SA R
Sbjct: 1029 KSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS-----WTSR 1083
Query: 709 KSVFSIRARNLLEKETAVTKILRACTRQRMLSGSFEGQPAKERSILSVQHHIRQERRSLR 768
+S +RN L + ++ + + R+ +LSG EGQ +++ S + R
Sbjct: 1084 RS-----SRNSLGRAPSLKRRSPSGERRSLLSG--EGQESQDEEESSEEERASPAGSDHR 1136
Query: 769 HGSNSQRISRGKSLETLTQDHSNTVRYRNAQREDSEIKMIQEKKEQAEMKRKVQEEELRE 828
H + +R ++ T R + + SE + K + R ++ ++
Sbjct: 1137 HRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPL 1196
Query: 829 NHPYFDKPLFIVGREHRFRNFCRVVVRARFNASKTDPVTGAVKNTKYHQLYDLL--GLVT 886
+ D + E R +RAR A + + + + LL ++T
Sbjct: 1197 DGDDADDEGNLSKGER-----VRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIIT 1251
Query: 887 Y--LDWVMIIVTICSCISMMFESPFRRVMHAPT--LQIAEYVFVIFMSIELNLKIMADGL 942
+ D V++++ +CI++ E P A L ++ Y+F E+ +K++A G
Sbjct: 1252 HKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGW 1311
Query: 943 FFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLL------MVLRCLRPLRI 996
F A +R V+D + L+S+I + ++ ++SG ++L +LR LRPLR+
Sbjct: 1312 CFGEQAYLRSSWNVLDGLLVLISVIDIL---VSMVSDSGTKILGMLRVLRLLRTLRPLRV 1368
Query: 997 FKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDP---NIIR 1053
++ VV L S K I + ++ ++F GVQLF GK C NI
Sbjct: 1369 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1428
Query: 1054 REDC-NGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVL 1112
+ DC +R WV +NFDN+G A+++LF +
Sbjct: 1429 KSDCAEASYR----------------------WVRH------KYNFDNLGQALMSLFVLA 1460
Query: 1113 SLKGWVEVRDVIIHRVG----------PIHGIYIHVFVFLGCMIGLTLFVGVVIANFNEN 1162
S GWV++ + VG P +Y F+ + L +FVGVV+ NF++
Sbjct: 1461 SKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKC 1520
Query: 1163 KGTALLTVDQRRWEDLKSRL--KIAQPLHLPPRPDNDGFRAKMYDITQHPFFKRTIALLV 1220
+ +RR E RL K + P D FR ++ + + I ++
Sbjct: 1521 RQHQEEEEARRREEKRLRRLEKKRRKAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVI 1580
Query: 1221 LAQSVLLSVK-WDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLL 1279
V ++++ + + L + +FT IFVLE K++A F+Q R N+ DL
Sbjct: 1581 GLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLA 1640
Query: 1280 VTSLGVVWVVLHFALLNAYTYMMGACVIVFRFFSICGKHVTLKM------LLLTVVVSMY 1333
+ L ++ + L +NA + + + R I LKM LL TV+ ++
Sbjct: 1641 IVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALP 1700
Query: 1334 KSFFIIVGMFLLLLCYAFAGVVLFGTVKYGEN-----INRHANFSSAGKAITVLFRIVTG 1388
+ + + LL +A GV LFG ++ E + RHA F + G A LFR+ TG
Sbjct: 1701 QVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTG 1760
Query: 1389 EDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVE 1448
++WN IM D + C + + C N + +YF SF + ++++N+++A++++
Sbjct: 1761 DNWNGIMKDTLRD---CDQE------STCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMK 1811
Query: 1449 N 1449
+
Sbjct: 1812 H 1812
Score = 134 bits (338), Expect = 6e-31
Identities = 134/646 (20%), Positives = 283/646 (43%), Gaps = 91/646 (14%)
Query: 34 NKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIR 93
+K + H +L + ++ I++ M P H ++T + + + ++ AEM K+
Sbjct: 1252 HKMFDHVVL-VIIFLNCITIAMERPKIDPHSAERIFLTLS-NYIFTAVFLAEMTVKVVAL 1309
Query: 94 GIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRA 153
G G+ +Y++ W V DG +V + +++ + ++D ++ GMLR+ R L +R
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM--VSDSGTKIL--GMLRVLRLLRTLRP 1365
Query: 154 FRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTK 213
R+ R + + + L S + I ++ + F +++GILGVQ+F + C DT+
Sbjct: 1366 LRVISRAQGLKL-VVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTR 1424
Query: 214 PGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTV 273
N+T S C+ E Y R F+ +G ++ ++
Sbjct: 1425 --NITNKS------DCA---EASY-----------------RWVRHKYNFDNLGQALMSL 1456
Query: 274 YEAASQEGWVFLMYRAID----------SFPRWRSYFYFITLIFFLAWLVKNVFIAVIIE 323
+ AS++GWV +MY +D + W YFI+ + +A+ V N+F+ V++E
Sbjct: 1457 FVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW-MLLYFISFLLIVAFFVLNMFVGVVVE 1515
Query: 324 TFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPACLQKMMRS 383
F + R ++ R + A R + + S
Sbjct: 1516 NFHKCRQHQEEEEARRREEKRLRRLEKKRRKAQ------CKPYYSDYSRFRLLVHHLCTS 1569
Query: 384 SVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFT 443
+FI ++ ++V+ A +Y+ + + FTV+F LE++ K+ GF
Sbjct: 1570 HYLDLFITGVIGLNVVTMAMEHYQQPQILD--EALKICNYIFTVIFVLESVFKLVAFGFR 1627
Query: 444 GYISSSLHKFELLLV-------------IGTTLHVYPDLYHSQFTYFQVLRVVRLIKISP 490
+ ++ +L +V + +L + P + ++ RV++L+K++
Sbjct: 1628 RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRI-MRVLRIARVLKLLKMAV 1686
Query: 491 ALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFV--------EELDR---FTT 539
+ + + ++G+L + L + +A+ +++F + E L R F
Sbjct: 1687 GMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRN 1746
Query: 540 FPRAFMSMFQILTQEGWVDVMDQTL---NAVGHMWAPVVA-IYFILYHLFATLILLSLFV 595
F AF+++F++ T + W +M TL + + V++ IYF+ + L A +L+++ +
Sbjct: 1747 FGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVI 1806
Query: 596 AVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRP 641
AV++ +LE + K+++ A+ + +L L ++ P+ P
Sbjct: 1807 AVLMKHLE--------ESNKEAKEEAELEAELELEMKTLSPQPHSP 1844
Score = 81.3 bits (199), Expect = 8e-15
Identities = 59/249 (23%), Positives = 118/249 (47%), Gaps = 24/249 (9%)
Query: 1206 ITQHPFFKRTIALLVLAQSVLLSVKWDVE-DPVTVPLATMSVVFTFIFVLEVTMKIIAMS 1264
I +F R I + +L ++ + +++ + + +T L ++VFT +F LE+ +K++
Sbjct: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
Query: 1265 PAGFWQSRRNRYDLLVTSLGVVWVVLHF---ALLNAYTYMMGACVIVFRFFSICGKHVTL 1321
P G+ ++ N +D ++ + V W ++ L T+ + + + RF + + +
Sbjct: 799 PFGYIKNPYNIFDGVIVVISV-WEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVV 857
Query: 1322 KMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAITV 1381
M + V + + + +F +L + F F + + G+ + NF S AI
Sbjct: 858 LMKTMDNVATFCMLLMLFIFIFSILGMHLFG--CKFASERDGDTLPDRKNFDSLLWAIVT 915
Query: 1382 LFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNL 1441
+F+I+T EDWNK++++ M + WA +YF + Y++ NL
Sbjct: 916 VFQILTQEDWNKVLYNGMAST--------SSWAA---------LYFIALMTFGNYVLFNL 958
Query: 1442 LVAIIVENF 1450
LVAI+VE F
Sbjct: 959 LVAILVEGF 967
Score = 81.3 bits (199), Expect = 8e-15
Identities = 74/320 (23%), Positives = 135/320 (42%), Gaps = 55/320 (17%)
Query: 369 PQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVL 428
PQ R +++ +F +L ++ ++ I A K + + L+ FT +
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
Query: 429 FDLEALLKI----WCLGFTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFT--------- 475
F E +K+ WC G Y+ SS + + LLV+ + + + + T
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
Query: 476 -YFQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF------ 528
+ LR +R+I + L+ V + K +G++VV + I+ + +Q+F
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Query: 529 --------------C------FVEELDRFTTFPRAFMSMFQILTQEGWVDVMDQTLNAVG 568
C +V F +A MS+F + +++GWVD+M L+AVG
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 569 HMWAPV------VAIYFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSEANAD 622
P+ + +YFI + L +L++FV V+++N K +Q ++ E
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFH------KCRQHQEEEEARR 1531
Query: 623 TKEKLPLRLRIFEKFPNRPQ 642
+EK RLR EK + Q
Sbjct: 1532 REEK---RLRRLEKKRRKAQ 1548
Score = 68.2 bits (165), Expect = 7e-11
Identities = 66/304 (21%), Positives = 134/304 (44%), Gaps = 50/304 (16%)
Query: 1194 PDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVP---LATMSVVFTF 1250
P FR + I H F + +++ + ++++ DP + L + +FT
Sbjct: 1237 PPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTA 1296
Query: 1251 IFVLEVTMKIIAMS----PAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACV 1306
+F+ E+T+K++A+ + +S N D L+ + V+ +++ + ++ T ++G
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM-VSDSGTKILGMLR 1355
Query: 1307 IV-----FRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGT-- 1359
++ R + + LK+++ T++ S+ I+V + + GV LF
Sbjct: 1356 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1415
Query: 1360 -VKYGENIN----------------RHA-NFSSAGKAITVLFRIVTGEDWNKIMHDCMV- 1400
V GE+ RH NF + G+A+ LF + + + W IM+D +
Sbjct: 1416 FVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDA 1475
Query: 1401 ----QPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYST 1456
Q P + + L+YF SF +I+A+ +LN+ V ++VENF
Sbjct: 1476 VGVDQQPIMNHNPWM------------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH 1523
Query: 1457 EEDQ 1460
+E++
Sbjct: 1524 QEEE 1527
Score = 62.0 bits (149), Expect = 5e-09
Identities = 59/277 (21%), Positives = 123/277 (44%), Gaps = 60/277 (21%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWC 108
+I++ +NT M E++ + +T L+ + ++T+ +M ++ +V G Y+K+ +
Sbjct: 750 MIAILVNTLSMGIEYHEQPEELTNALE-ISNIVFTSLFALEMLLKLLVYGPFGYIKNPYN 808
Query: 109 VFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRIT 168
+FDG +V V + +IV Q G L + R ++R ++ RF R
Sbjct: 809 IFDGVIV----------VISVWEIVGQQG--GGLSVLRTFRLMRVLKLV-RFLPALQRQL 855
Query: 169 NILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTH 228
+L ++ + + + + L+ F+ ++ ILG+ +FG C + G+ +PD
Sbjct: 856 VVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-----CKFASERDGD------TLPDR- 903
Query: 229 CSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYR 288
F+ + +I TV++ +QE W ++Y
Sbjct: 904 --------------------------------KNFDSLLWAIVTVFQILTQEDWNKVLYN 931
Query: 289 AIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETF 325
+ S W + YFI L+ F +++ N+ +A+++E F
Sbjct: 932 GMASTSSWAA-LYFIALMTFGNYVLFNLLVAILVEGF 967
Score = 53.1 bits (126), Expect = 2e-06
Identities = 72/346 (20%), Positives = 128/346 (36%), Gaps = 61/346 (17%)
Query: 32 WINKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMH 91
W + + +L C + + C + + LQ D + + EM+ KM
Sbjct: 82 WFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQ----AFDDFIFAFFAVEMVVKMV 137
Query: 92 IRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMI 151
GI G Y+ D W D F+V + L + ++ S +R+ RPL I
Sbjct: 138 ALGIF-GKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-----FSAVRTVRVLRPLRAI 191
Query: 152 RAFRIYFRFELPRTRI-TNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF-GTFTYHCVV 209
+P RI +L + + +V + F ++GI+GVQ++ G C +
Sbjct: 192 N--------RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL 243
Query: 210 --NDTKPGNVTWNSLAIPDTH------CSPELEEG------------------------- 236
N + P +V + CS E G
Sbjct: 244 PENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYE 303
Query: 237 -YQCPPGFKCMDLEDL------GLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRA 289
Y C++ G G F+ IG + +++ + EGWV +MY
Sbjct: 304 AYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFV 363
Query: 290 IDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQM 335
+D+ + ++ YFI LI ++ + N+ + VI F+E + + Q+
Sbjct: 364 MDAH-SFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQL 408
Score = 50.8 bits (120), Expect = 1e-05
Identities = 40/161 (24%), Positives = 73/161 (45%), Gaps = 9/161 (5%)
Query: 887 YLDWVMIIVTICSCISMMFESPFRRV----MHAPTLQIAEYVFVIFMSIELNLKIMADGL 942
+ + + ++V + +C+++ P + LQ + F ++E+ +K++A G+
Sbjct: 82 WFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGI 141
Query: 943 FFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQ 1002
F + D +D FI + ++ QNV + + +R LRPLR VP
Sbjct: 142 F-GKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSA----VRTVRVLRPLRAINRVPS 196
Query: 1003 MRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKL 1043
MR +V L + V +L + +F GVQL+AG L
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLL 237
Score = 48.9 bits (115), Expect = 4e-05
Identities = 21/67 (31%), Positives = 40/67 (59%)
Query: 1097 NFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVGPIHGIYIHVFVFLGCMIGLTLFVGVVI 1156
NFDN+G A +A+F+V++L+GWV++ ++ + IY + + +G + L + V+
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
Query: 1157 ANFNENK 1163
F+E K
Sbjct: 396 TQFSETK 402
Score = 37.4 bits (85), Expect = 0.13
Identities = 21/62 (33%), Positives = 37/62 (59%), Gaps = 4/62 (6%)
Query: 537 FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVA 596
F A++++FQ++T EGWVD+M ++A H + IYFIL + + +++L +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDA--HSFYNF--IYFILLIIVGSFFMINLCLV 392
Query: 597 VI 598
VI
Sbjct: 393 VI 394
Score = 35.8 bits (81), Expect = 0.37
Identities = 29/128 (22%), Positives = 52/128 (40%), Gaps = 18/128 (14%)
Query: 1371 NFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSF 1430
NF + G A +F+++T E W IM Y+ D ++ +YF
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIM----------------YFVMDAHSFYN-FIYFILL 378
Query: 1431 YVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRV 1490
++ ++ M+NL + +I FS E QL+ +R + G +
Sbjct: 379 IIVGSFFMINLCLVVIATQFS-ETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELL 437
Query: 1491 KFLLRLLR 1498
K+L+ +LR
Sbjct: 438 KYLVYILR 445
Score = 33.9 bits (76), Expect = 1.4
Identities = 29/132 (21%), Positives = 59/132 (44%), Gaps = 19/132 (14%)
Query: 415 YDEFYLAEVAFTVLFDLEALLKIWCLGFTG---YISSSLHKFELLLVIGTTLHVYPDLYH 471
+D+F A F +E ++K+ LG G Y+ + ++ + +VI L DL +
Sbjct: 120 FDDFIFA------FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQN 173
Query: 472 SQFTYFQ---VLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF 528
F+ + VLR +R I P++ V + LG++++ + + + +Q++
Sbjct: 174 VSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Query: 529 -------CFVEE 533
CF+ E
Sbjct: 234 AGLLRNRCFLPE 245
>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
isoform 3 [Homo sapiens]
Length = 2343
Score = 224 bits (570), Expect = 7e-58
Identities = 263/1148 (22%), Positives = 484/1148 (42%), Gaps = 141/1148 (12%)
Query: 378 QKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKI 437
+K++ S F I+ + V+ + Y+ E + ++ + FT LF LE LLK+
Sbjct: 737 RKIVDSKYFGRGIMIAILVNTLSMGIEYH--EQPEELTNALEISNIVFTSLFALEMLLKL 794
Query: 438 WCLGFTGYISSSLHKFELLLVIGTTLHVYPDLYH--SQFTYFQVLRVVRLIKISPALEDF 495
G GYI + + F+ ++V+ + + S F+++RV++L++ PAL+
Sbjct: 795 LVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQ 854
Query: 496 VYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF-C-FVEELD--------RFTTFPRAFM 545
+ + + + + + + S + + +F C F E D F + A +
Sbjct: 855 LVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIV 914
Query: 546 SMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVAVILDNLELD 605
++FQILTQE W V+ + + WA A+YFI F +L +L VA++++ + +
Sbjct: 915 TVFQILTQEDWNKVLYNGMASTSS-WA---ALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Query: 606 EDLKKLKQ---LKQSEANADTKEKLPLRLRIFEKFPNR------PQMVKISKLPSDFTVP 656
D K + + D K L L + P P ++ + P ++P
Sbjct: 971 GDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATP--MSLP 1028
Query: 657 KIRESFMKQFIDRQQQDTCCLLRSLPTT--------SSSSCDHSKRSAIEDNKYIDQKLR 708
K + + + + + T + P S+ S HS SA R
Sbjct: 1029 KSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS-----WTSR 1083
Query: 709 KSVFSIRARNLLEKETAVTKILRACTRQRMLSGSFEGQPAKERSILSVQHHIRQERRSLR 768
+S +RN L + ++ + + R+ +LSG EGQ +++ S + R
Sbjct: 1084 RS-----SRNSLGRAPSLKRRSPSGERRSLLSG--EGQESQDEEESSEEERASPAGSDHR 1136
Query: 769 HGSNSQRISRGKSLETLTQDHSNTVRYRNAQREDSEIKMIQEKKEQAEMKRKVQEEELRE 828
H + +R ++ T R + + SE + K + R ++ ++
Sbjct: 1137 HRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPL 1196
Query: 829 NHPYFDKPLFIVGREHRFRNFCRVVVRARFNASKTDPVTGAVKNTKYHQLYDLL--GLVT 886
+ D + E R +RAR A + + + + LL ++T
Sbjct: 1197 DGDDADDEGNLSKGER-----VRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIIT 1251
Query: 887 Y--LDWVMIIVTICSCISMMFESPFRRVMHAPT--LQIAEYVFVIFMSIELNLKIMADGL 942
+ D V++++ +CI++ E P A L ++ Y+F E+ +K++A G
Sbjct: 1252 HKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGW 1311
Query: 943 FFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLL------MVLRCLRPLRI 996
F A +R V+D + L+S+I + ++ ++SG ++L +LR LRPLR+
Sbjct: 1312 CFGEQAYLRSSWNVLDGLLVLISVIDIL---VSMVSDSGTKILGMLRVLRLLRTLRPLRV 1368
Query: 997 FKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDP---NIIR 1053
++ VV L S K I + ++ ++F GVQLF GK C NI
Sbjct: 1369 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1428
Query: 1054 REDC-NGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVL 1112
+ DC +R WV +NFDN+G A+++LF +
Sbjct: 1429 KSDCAEASYR----------------------WVRH------KYNFDNLGQALMSLFVLA 1460
Query: 1113 SLKGWVEVRDVIIHRVG----------PIHGIYIHVFVFLGCMIGLTLFVGVVIANFNEN 1162
S GWV++ + VG P +Y F+ + L +FVGVV+ NF++
Sbjct: 1461 SKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKC 1520
Query: 1163 KGTALLTVDQRRWEDLKSRLK---------IAQPLHLPPRPDNDGFRAKMYDITQHPFFK 1213
+ +RR E RL+ +A+ P D FR ++ + +
Sbjct: 1521 RQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLD 1580
Query: 1214 RTIALLVLAQSVLLSVK-WDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSR 1272
I ++ V ++++ + + L + +FT IFVLE K++A F+Q R
Sbjct: 1581 LFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDR 1640
Query: 1273 RNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACVIVFRFFSICGKHVTLKM------LLL 1326
N+ DL + L ++ + L +NA + + + R I LKM LL
Sbjct: 1641 WNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLD 1700
Query: 1327 TVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGEN-----INRHANFSSAGKAITV 1381
TV+ ++ + + + LL +A GV LFG ++ E + RHA F + G A
Sbjct: 1701 TVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLT 1760
Query: 1382 LFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNL 1441
LFR+ TG++WN IM D + C + + C N + +YF SF + ++++N+
Sbjct: 1761 LFRVSTGDNWNGIMKDTLRD---CDQE------STCYNTVISPIYFVSFVLTAQFVLVNV 1811
Query: 1442 LVAIIVEN 1449
++A+++++
Sbjct: 1812 VIAVLMKH 1819
Score = 134 bits (337), Expect = 8e-31
Identities = 136/650 (20%), Positives = 287/650 (44%), Gaps = 92/650 (14%)
Query: 34 NKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIR 93
+K + H +L + ++ I++ M P H ++T + + + ++ AEM K+
Sbjct: 1252 HKMFDHVVL-VIIFLNCITIAMERPKIDPHSAERIFLTLS-NYIFTAVFLAEMTVKVVAL 1309
Query: 94 GIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRA 153
G G+ +Y++ W V DG +V + +++ + ++D ++ GMLR+ R L +R
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM--VSDSGTKIL--GMLRVLRLLRTLRP 1365
Query: 154 FRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTK 213
R+ R + + + L S + I ++ + F +++GILGVQ+F + C DT+
Sbjct: 1366 LRVISRAQGLKL-VVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTR 1424
Query: 214 PGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTV 273
N+T S C+ E Y R F+ +G ++ ++
Sbjct: 1425 --NITNKS------DCA---EASY-----------------RWVRHKYNFDNLGQALMSL 1456
Query: 274 YEAASQEGWVFLMYRAID----------SFPRWRSYFYFITLIFFLAWLVKNVFIAVIIE 323
+ AS++GWV +MY +D + W YFI+ + +A+ V N+F+ V++E
Sbjct: 1457 FVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW-MLLYFISFLLIVAFFVLNMFVGVVVE 1515
Query: 324 TFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKP----QGRAPACLQK 379
F + R Q + + + + +A KP R +
Sbjct: 1516 NFHKCR---QHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHH 1572
Query: 380 MMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWC 439
+ S +FI ++ ++V+ A +Y+ + + FTV+F LE++ K+
Sbjct: 1573 LCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILD--EALKICNYIFTVIFVLESVFKLVA 1630
Query: 440 LGFTGYISSSLHKFELLLV-------------IGTTLHVYPDLYHSQFTYFQVLRVVRLI 486
GF + ++ +L +V + +L + P + ++ RV++L+
Sbjct: 1631 FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRI-MRVLRIARVLKLL 1689
Query: 487 KISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFV--------EELDR-- 536
K++ + + + ++G+L + L + +A+ +++F + E L R
Sbjct: 1690 KMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHA 1749
Query: 537 -FTTFPRAFMSMFQILTQEGWVDVMDQTL---NAVGHMWAPVVA-IYFILYHLFATLILL 591
F F AF+++F++ T + W +M TL + + V++ IYF+ + L A +L+
Sbjct: 1750 TFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLV 1809
Query: 592 SLFVAVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRP 641
++ +AV++ +LE + K+++ A+ + +L L ++ P+ P
Sbjct: 1810 NVVIAVLMKHLE--------ESNKEAKEEAELEAELELEMKTLSPQPHSP 1851
Score = 81.3 bits (199), Expect = 8e-15
Identities = 59/249 (23%), Positives = 118/249 (47%), Gaps = 24/249 (9%)
Query: 1206 ITQHPFFKRTIALLVLAQSVLLSVKWDVE-DPVTVPLATMSVVFTFIFVLEVTMKIIAMS 1264
I +F R I + +L ++ + +++ + + +T L ++VFT +F LE+ +K++
Sbjct: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
Query: 1265 PAGFWQSRRNRYDLLVTSLGVVWVVLHF---ALLNAYTYMMGACVIVFRFFSICGKHVTL 1321
P G+ ++ N +D ++ + V W ++ L T+ + + + RF + + +
Sbjct: 799 PFGYIKNPYNIFDGVIVVISV-WEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVV 857
Query: 1322 KMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAITV 1381
M + V + + + +F +L + F F + + G+ + NF S AI
Sbjct: 858 LMKTMDNVATFCMLLMLFIFIFSILGMHLFG--CKFASERDGDTLPDRKNFDSLLWAIVT 915
Query: 1382 LFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNL 1441
+F+I+T EDWNK++++ M + WA +YF + Y++ NL
Sbjct: 916 VFQILTQEDWNKVLYNGMAST--------SSWAA---------LYFIALMTFGNYVLFNL 958
Query: 1442 LVAIIVENF 1450
LVAI+VE F
Sbjct: 959 LVAILVEGF 967
Score = 80.9 bits (198), Expect = 1e-14
Identities = 73/314 (23%), Positives = 133/314 (42%), Gaps = 55/314 (17%)
Query: 369 PQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVL 428
PQ R +++ +F +L ++ ++ I A K + + L+ FT +
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
Query: 429 FDLEALLKI----WCLGFTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFT--------- 475
F E +K+ WC G Y+ SS + + LLV+ + + + + T
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
Query: 476 -YFQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF------ 528
+ LR +R+I + L+ V + K +G++VV + I+ + +Q+F
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Query: 529 --------------C------FVEELDRFTTFPRAFMSMFQILTQEGWVDVMDQTLNAVG 568
C +V F +A MS+F + +++GWVD+M L+AVG
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 569 HMWAPV------VAIYFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSEANAD 622
P+ + +YFI + L +L++FV V+++N K +Q ++ E
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFH------KCRQHQEEEEARR 1531
Query: 623 TKEKLPLRLRIFEK 636
+EK RLR EK
Sbjct: 1532 REEK---RLRRLEK 1542
Score = 68.2 bits (165), Expect = 7e-11
Identities = 66/304 (21%), Positives = 134/304 (44%), Gaps = 50/304 (16%)
Query: 1194 PDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVP---LATMSVVFTF 1250
P FR + I H F + +++ + ++++ DP + L + +FT
Sbjct: 1237 PPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTA 1296
Query: 1251 IFVLEVTMKIIAMS----PAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACV 1306
+F+ E+T+K++A+ + +S N D L+ + V+ +++ + ++ T ++G
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM-VSDSGTKILGMLR 1355
Query: 1307 IV-----FRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGT-- 1359
++ R + + LK+++ T++ S+ I+V + + GV LF
Sbjct: 1356 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1415
Query: 1360 -VKYGENIN----------------RHA-NFSSAGKAITVLFRIVTGEDWNKIMHDCMV- 1400
V GE+ RH NF + G+A+ LF + + + W IM+D +
Sbjct: 1416 FVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDA 1475
Query: 1401 ----QPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYST 1456
Q P + + L+YF SF +I+A+ +LN+ V ++VENF
Sbjct: 1476 VGVDQQPIMNHNPWM------------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH 1523
Query: 1457 EEDQ 1460
+E++
Sbjct: 1524 QEEE 1527
Score = 62.0 bits (149), Expect = 5e-09
Identities = 59/277 (21%), Positives = 123/277 (44%), Gaps = 60/277 (21%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWC 108
+I++ +NT M E++ + +T L+ + ++T+ +M ++ +V G Y+K+ +
Sbjct: 750 MIAILVNTLSMGIEYHEQPEELTNALE-ISNIVFTSLFALEMLLKLLVYGPFGYIKNPYN 808
Query: 109 VFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRIT 168
+FDG +V V + +IV Q G L + R ++R ++ RF R
Sbjct: 809 IFDGVIV----------VISVWEIVGQQG--GGLSVLRTFRLMRVLKLV-RFLPALQRQL 855
Query: 169 NILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTH 228
+L ++ + + + + L+ F+ ++ ILG+ +FG C + G+ +PD
Sbjct: 856 VVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-----CKFASERDGD------TLPDR- 903
Query: 229 CSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYR 288
F+ + +I TV++ +QE W ++Y
Sbjct: 904 --------------------------------KNFDSLLWAIVTVFQILTQEDWNKVLYN 931
Query: 289 AIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETF 325
+ S W + YFI L+ F +++ N+ +A+++E F
Sbjct: 932 GMASTSSWAA-LYFIALMTFGNYVLFNLLVAILVEGF 967
Score = 53.1 bits (126), Expect = 2e-06
Identities = 72/346 (20%), Positives = 128/346 (36%), Gaps = 61/346 (17%)
Query: 32 WINKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMH 91
W + + +L C + + C + + LQ D + + EM+ KM
Sbjct: 82 WFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQ----AFDDFIFAFFAVEMVVKMV 137
Query: 92 IRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMI 151
GI G Y+ D W D F+V + L + ++ S +R+ RPL I
Sbjct: 138 ALGIF-GKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-----FSAVRTVRVLRPLRAI 191
Query: 152 RAFRIYFRFELPRTRI-TNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF-GTFTYHCVV 209
+P RI +L + + +V + F ++GI+GVQ++ G C +
Sbjct: 192 N--------RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL 243
Query: 210 --NDTKPGNVTWNSLAIPDTH------CSPELEEG------------------------- 236
N + P +V + CS E G
Sbjct: 244 PENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYE 303
Query: 237 -YQCPPGFKCMDLEDL------GLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRA 289
Y C++ G G F+ IG + +++ + EGWV +MY
Sbjct: 304 AYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFV 363
Query: 290 IDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQM 335
+D+ + ++ YFI LI ++ + N+ + VI F+E + + Q+
Sbjct: 364 MDAH-SFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQL 408
Score = 50.8 bits (120), Expect = 1e-05
Identities = 40/161 (24%), Positives = 73/161 (45%), Gaps = 9/161 (5%)
Query: 887 YLDWVMIIVTICSCISMMFESPFRRV----MHAPTLQIAEYVFVIFMSIELNLKIMADGL 942
+ + + ++V + +C+++ P + LQ + F ++E+ +K++A G+
Sbjct: 82 WFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGI 141
Query: 943 FFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQ 1002
F + D +D FI + ++ QNV + + +R LRPLR VP
Sbjct: 142 F-GKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSA----VRTVRVLRPLRAINRVPS 196
Query: 1003 MRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKL 1043
MR +V L + V +L + +F GVQL+AG L
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLL 237
Score = 48.9 bits (115), Expect = 4e-05
Identities = 21/67 (31%), Positives = 40/67 (59%)
Query: 1097 NFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVGPIHGIYIHVFVFLGCMIGLTLFVGVVI 1156
NFDN+G A +A+F+V++L+GWV++ ++ + IY + + +G + L + V+
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
Query: 1157 ANFNENK 1163
F+E K
Sbjct: 396 TQFSETK 402
Score = 37.4 bits (85), Expect = 0.13
Identities = 21/62 (33%), Positives = 37/62 (59%), Gaps = 4/62 (6%)
Query: 537 FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVA 596
F A++++FQ++T EGWVD+M ++A H + IYFIL + + +++L +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDA--HSFYNF--IYFILLIIVGSFFMINLCLV 392
Query: 597 VI 598
VI
Sbjct: 393 VI 394
Score = 35.8 bits (81), Expect = 0.37
Identities = 29/128 (22%), Positives = 52/128 (40%), Gaps = 18/128 (14%)
Query: 1371 NFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSF 1430
NF + G A +F+++T E W IM Y+ D ++ +YF
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIM----------------YFVMDAHSFYN-FIYFILL 378
Query: 1431 YVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRV 1490
++ ++ M+NL + +I FS E QL+ +R + G +
Sbjct: 379 IIVGSFFMINLCLVVIATQFS-ETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELL 437
Query: 1491 KFLLRLLR 1498
K+L+ +LR
Sbjct: 438 KYLVYILR 445
Score = 33.9 bits (76), Expect = 1.4
Identities = 29/132 (21%), Positives = 59/132 (44%), Gaps = 19/132 (14%)
Query: 415 YDEFYLAEVAFTVLFDLEALLKIWCLGFTG---YISSSLHKFELLLVIGTTLHVYPDLYH 471
+D+F A F +E ++K+ LG G Y+ + ++ + +VI L DL +
Sbjct: 120 FDDFIFA------FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQN 173
Query: 472 SQFTYFQ---VLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF 528
F+ + VLR +R I P++ V + LG++++ + + + +Q++
Sbjct: 174 VSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Query: 529 -------CFVEE 533
CF+ E
Sbjct: 234 AGLLRNRCFLPE 245
>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
isoform 12 [Homo sapiens]
Length = 2250
Score = 224 bits (570), Expect = 7e-58
Identities = 263/1148 (22%), Positives = 484/1148 (42%), Gaps = 141/1148 (12%)
Query: 378 QKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKI 437
+K++ S F I+ + V+ + Y+ E + ++ + FT LF LE LLK+
Sbjct: 737 RKIVDSKYFGRGIMIAILVNTLSMGIEYH--EQPEELTNALEISNIVFTSLFALEMLLKL 794
Query: 438 WCLGFTGYISSSLHKFELLLVIGTTLHVYPDLYH--SQFTYFQVLRVVRLIKISPALEDF 495
G GYI + + F+ ++V+ + + S F+++RV++L++ PAL+
Sbjct: 795 LVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQ 854
Query: 496 VYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF-C-FVEELD--------RFTTFPRAFM 545
+ + + + + + + S + + +F C F E D F + A +
Sbjct: 855 LVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIV 914
Query: 546 SMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVAVILDNLELD 605
++FQILTQE W V+ + + WA A+YFI F +L +L VA++++ + +
Sbjct: 915 TVFQILTQEDWNKVLYNGMASTSS-WA---ALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Query: 606 EDLKKLKQ---LKQSEANADTKEKLPLRLRIFEKFPNR------PQMVKISKLPSDFTVP 656
D K + + D K L L + P P ++ + P ++P
Sbjct: 971 GDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATP--MSLP 1028
Query: 657 KIRESFMKQFIDRQQQDTCCLLRSLPTT--------SSSSCDHSKRSAIEDNKYIDQKLR 708
K + + + + + T + P S+ S HS SA R
Sbjct: 1029 KSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS-----WTSR 1083
Query: 709 KSVFSIRARNLLEKETAVTKILRACTRQRMLSGSFEGQPAKERSILSVQHHIRQERRSLR 768
+S +RN L + ++ + + R+ +LSG EGQ +++ S + R
Sbjct: 1084 RS-----SRNSLGRAPSLKRRSPSGERRSLLSG--EGQESQDEEESSEEERASPAGSDHR 1136
Query: 769 HGSNSQRISRGKSLETLTQDHSNTVRYRNAQREDSEIKMIQEKKEQAEMKRKVQEEELRE 828
H + +R ++ T R + + SE + K + R ++ ++
Sbjct: 1137 HRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPL 1196
Query: 829 NHPYFDKPLFIVGREHRFRNFCRVVVRARFNASKTDPVTGAVKNTKYHQLYDLL--GLVT 886
+ D + E R +RAR A + + + + LL ++T
Sbjct: 1197 DGDDADDEGNLSKGER-----VRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIIT 1251
Query: 887 Y--LDWVMIIVTICSCISMMFESPFRRVMHAPT--LQIAEYVFVIFMSIELNLKIMADGL 942
+ D V++++ +CI++ E P A L ++ Y+F E+ +K++A G
Sbjct: 1252 HKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGW 1311
Query: 943 FFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLL------MVLRCLRPLRI 996
F A +R V+D + L+S+I + ++ ++SG ++L +LR LRPLR+
Sbjct: 1312 CFGEQAYLRSSWNVLDGLLVLISVIDIL---VSMVSDSGTKILGMLRVLRLLRTLRPLRV 1368
Query: 997 FKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDP---NIIR 1053
++ VV L S K I + ++ ++F GVQLF GK C NI
Sbjct: 1369 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1428
Query: 1054 REDC-NGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVL 1112
+ DC +R WV +NFDN+G A+++LF +
Sbjct: 1429 KSDCAEASYR----------------------WVRH------KYNFDNLGQALMSLFVLA 1460
Query: 1113 SLKGWVEVRDVIIHRVG----------PIHGIYIHVFVFLGCMIGLTLFVGVVIANFNEN 1162
S GWV++ + VG P +Y F+ + L +FVGVV+ NF++
Sbjct: 1461 SKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKC 1520
Query: 1163 KGTALLTVDQRRWEDLKSRLK---------IAQPLHLPPRPDNDGFRAKMYDITQHPFFK 1213
+ +RR E RL+ +A+ P D FR ++ + +
Sbjct: 1521 RQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLD 1580
Query: 1214 RTIALLVLAQSVLLSVK-WDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSR 1272
I ++ V ++++ + + L + +FT IFVLE K++A F+Q R
Sbjct: 1581 LFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDR 1640
Query: 1273 RNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACVIVFRFFSICGKHVTLKM------LLL 1326
N+ DL + L ++ + L +NA + + + R I LKM LL
Sbjct: 1641 WNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLD 1700
Query: 1327 TVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGEN-----INRHANFSSAGKAITV 1381
TV+ ++ + + + LL +A GV LFG ++ E + RHA F + G A
Sbjct: 1701 TVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLT 1760
Query: 1382 LFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNL 1441
LFR+ TG++WN IM D + C + + C N + +YF SF + ++++N+
Sbjct: 1761 LFRVSTGDNWNGIMKDTLRD---CDQE------STCYNTVISPIYFVSFVLTAQFVLVNV 1811
Query: 1442 LVAIIVEN 1449
++A+++++
Sbjct: 1812 VIAVLMKH 1819
Score = 134 bits (337), Expect = 8e-31
Identities = 136/650 (20%), Positives = 287/650 (44%), Gaps = 92/650 (14%)
Query: 34 NKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIR 93
+K + H +L + ++ I++ M P H ++T + + + ++ AEM K+
Sbjct: 1252 HKMFDHVVL-VIIFLNCITIAMERPKIDPHSAERIFLTLS-NYIFTAVFLAEMTVKVVAL 1309
Query: 94 GIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRA 153
G G+ +Y++ W V DG +V + +++ + ++D ++ GMLR+ R L +R
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM--VSDSGTKIL--GMLRVLRLLRTLRP 1365
Query: 154 FRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTK 213
R+ R + + + L S + I ++ + F +++GILGVQ+F + C DT+
Sbjct: 1366 LRVISRAQGLKL-VVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTR 1424
Query: 214 PGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTV 273
N+T S C+ E Y R F+ +G ++ ++
Sbjct: 1425 --NITNKS------DCA---EASY-----------------RWVRHKYNFDNLGQALMSL 1456
Query: 274 YEAASQEGWVFLMYRAID----------SFPRWRSYFYFITLIFFLAWLVKNVFIAVIIE 323
+ AS++GWV +MY +D + W YFI+ + +A+ V N+F+ V++E
Sbjct: 1457 FVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW-MLLYFISFLLIVAFFVLNMFVGVVVE 1515
Query: 324 TFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKP----QGRAPACLQK 379
F + R Q + + + + +A KP R +
Sbjct: 1516 NFHKCR---QHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHH 1572
Query: 380 MMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWC 439
+ S +FI ++ ++V+ A +Y+ + + FTV+F LE++ K+
Sbjct: 1573 LCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILD--EALKICNYIFTVIFVLESVFKLVA 1630
Query: 440 LGFTGYISSSLHKFELLLV-------------IGTTLHVYPDLYHSQFTYFQVLRVVRLI 486
GF + ++ +L +V + +L + P + ++ RV++L+
Sbjct: 1631 FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRI-MRVLRIARVLKLL 1689
Query: 487 KISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFV--------EELDR-- 536
K++ + + + ++G+L + L + +A+ +++F + E L R
Sbjct: 1690 KMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHA 1749
Query: 537 -FTTFPRAFMSMFQILTQEGWVDVMDQTL---NAVGHMWAPVVA-IYFILYHLFATLILL 591
F F AF+++F++ T + W +M TL + + V++ IYF+ + L A +L+
Sbjct: 1750 TFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLV 1809
Query: 592 SLFVAVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRP 641
++ +AV++ +LE + K+++ A+ + +L L ++ P+ P
Sbjct: 1810 NVVIAVLMKHLE--------ESNKEAKEEAELEAELELEMKTLSPQPHSP 1851
Score = 81.3 bits (199), Expect = 8e-15
Identities = 59/249 (23%), Positives = 118/249 (47%), Gaps = 24/249 (9%)
Query: 1206 ITQHPFFKRTIALLVLAQSVLLSVKWDVE-DPVTVPLATMSVVFTFIFVLEVTMKIIAMS 1264
I +F R I + +L ++ + +++ + + +T L ++VFT +F LE+ +K++
Sbjct: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
Query: 1265 PAGFWQSRRNRYDLLVTSLGVVWVVLHF---ALLNAYTYMMGACVIVFRFFSICGKHVTL 1321
P G+ ++ N +D ++ + V W ++ L T+ + + + RF + + +
Sbjct: 799 PFGYIKNPYNIFDGVIVVISV-WEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVV 857
Query: 1322 KMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAITV 1381
M + V + + + +F +L + F F + + G+ + NF S AI
Sbjct: 858 LMKTMDNVATFCMLLMLFIFIFSILGMHLFG--CKFASERDGDTLPDRKNFDSLLWAIVT 915
Query: 1382 LFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNL 1441
+F+I+T EDWNK++++ M + WA +YF + Y++ NL
Sbjct: 916 VFQILTQEDWNKVLYNGMAST--------SSWAA---------LYFIALMTFGNYVLFNL 958
Query: 1442 LVAIIVENF 1450
LVAI+VE F
Sbjct: 959 LVAILVEGF 967
Score = 80.9 bits (198), Expect = 1e-14
Identities = 73/314 (23%), Positives = 133/314 (42%), Gaps = 55/314 (17%)
Query: 369 PQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVL 428
PQ R +++ +F +L ++ ++ I A K + + L+ FT +
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
Query: 429 FDLEALLKI----WCLGFTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFT--------- 475
F E +K+ WC G Y+ SS + + LLV+ + + + + T
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
Query: 476 -YFQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF------ 528
+ LR +R+I + L+ V + K +G++VV + I+ + +Q+F
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Query: 529 --------------C------FVEELDRFTTFPRAFMSMFQILTQEGWVDVMDQTLNAVG 568
C +V F +A MS+F + +++GWVD+M L+AVG
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 569 HMWAPV------VAIYFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSEANAD 622
P+ + +YFI + L +L++FV V+++N K +Q ++ E
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFH------KCRQHQEEEEARR 1531
Query: 623 TKEKLPLRLRIFEK 636
+EK RLR EK
Sbjct: 1532 REEK---RLRRLEK 1542
Score = 68.2 bits (165), Expect = 7e-11
Identities = 66/304 (21%), Positives = 134/304 (44%), Gaps = 50/304 (16%)
Query: 1194 PDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVP---LATMSVVFTF 1250
P FR + I H F + +++ + ++++ DP + L + +FT
Sbjct: 1237 PPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTA 1296
Query: 1251 IFVLEVTMKIIAMS----PAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACV 1306
+F+ E+T+K++A+ + +S N D L+ + V+ +++ + ++ T ++G
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM-VSDSGTKILGMLR 1355
Query: 1307 IV-----FRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGT-- 1359
++ R + + LK+++ T++ S+ I+V + + GV LF
Sbjct: 1356 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1415
Query: 1360 -VKYGENIN----------------RHA-NFSSAGKAITVLFRIVTGEDWNKIMHDCMV- 1400
V GE+ RH NF + G+A+ LF + + + W IM+D +
Sbjct: 1416 FVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDA 1475
Query: 1401 ----QPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYST 1456
Q P + + L+YF SF +I+A+ +LN+ V ++VENF
Sbjct: 1476 VGVDQQPIMNHNPWM------------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH 1523
Query: 1457 EEDQ 1460
+E++
Sbjct: 1524 QEEE 1527
Score = 62.0 bits (149), Expect = 5e-09
Identities = 59/277 (21%), Positives = 123/277 (44%), Gaps = 60/277 (21%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWC 108
+I++ +NT M E++ + +T L+ + ++T+ +M ++ +V G Y+K+ +
Sbjct: 750 MIAILVNTLSMGIEYHEQPEELTNALE-ISNIVFTSLFALEMLLKLLVYGPFGYIKNPYN 808
Query: 109 VFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRIT 168
+FDG +V V + +IV Q G L + R ++R ++ RF R
Sbjct: 809 IFDGVIV----------VISVWEIVGQQG--GGLSVLRTFRLMRVLKLV-RFLPALQRQL 855
Query: 169 NILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTH 228
+L ++ + + + + L+ F+ ++ ILG+ +FG C + G+ +PD
Sbjct: 856 VVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-----CKFASERDGD------TLPDR- 903
Query: 229 CSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYR 288
F+ + +I TV++ +QE W ++Y
Sbjct: 904 --------------------------------KNFDSLLWAIVTVFQILTQEDWNKVLYN 931
Query: 289 AIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETF 325
+ S W + YFI L+ F +++ N+ +A+++E F
Sbjct: 932 GMASTSSWAA-LYFIALMTFGNYVLFNLLVAILVEGF 967
Score = 53.1 bits (126), Expect = 2e-06
Identities = 72/346 (20%), Positives = 128/346 (36%), Gaps = 61/346 (17%)
Query: 32 WINKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMH 91
W + + +L C + + C + + LQ D + + EM+ KM
Sbjct: 82 WFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQ----AFDDFIFAFFAVEMVVKMV 137
Query: 92 IRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMI 151
GI G Y+ D W D F+V + L + ++ S +R+ RPL I
Sbjct: 138 ALGIF-GKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-----FSAVRTVRVLRPLRAI 191
Query: 152 RAFRIYFRFELPRTRI-TNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF-GTFTYHCVV 209
+P RI +L + + +V + F ++GI+GVQ++ G C +
Sbjct: 192 N--------RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL 243
Query: 210 --NDTKPGNVTWNSLAIPDTH------CSPELEEG------------------------- 236
N + P +V + CS E G
Sbjct: 244 PENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYE 303
Query: 237 -YQCPPGFKCMDLEDL------GLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRA 289
Y C++ G G F+ IG + +++ + EGWV +MY
Sbjct: 304 AYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFV 363
Query: 290 IDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQM 335
+D+ + ++ YFI LI ++ + N+ + VI F+E + + Q+
Sbjct: 364 MDAH-SFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQL 408
Score = 50.8 bits (120), Expect = 1e-05
Identities = 40/161 (24%), Positives = 73/161 (45%), Gaps = 9/161 (5%)
Query: 887 YLDWVMIIVTICSCISMMFESPFRRV----MHAPTLQIAEYVFVIFMSIELNLKIMADGL 942
+ + + ++V + +C+++ P + LQ + F ++E+ +K++A G+
Sbjct: 82 WFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGI 141
Query: 943 FFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQ 1002
F + D +D FI + ++ QNV + + +R LRPLR VP
Sbjct: 142 F-GKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSA----VRTVRVLRPLRAINRVPS 196
Query: 1003 MRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKL 1043
MR +V L + V +L + +F GVQL+AG L
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLL 237
Score = 48.9 bits (115), Expect = 4e-05
Identities = 21/67 (31%), Positives = 40/67 (59%)
Query: 1097 NFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVGPIHGIYIHVFVFLGCMIGLTLFVGVVI 1156
NFDN+G A +A+F+V++L+GWV++ ++ + IY + + +G + L + V+
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
Query: 1157 ANFNENK 1163
F+E K
Sbjct: 396 TQFSETK 402
Score = 37.4 bits (85), Expect = 0.13
Identities = 21/62 (33%), Positives = 37/62 (59%), Gaps = 4/62 (6%)
Query: 537 FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVA 596
F A++++FQ++T EGWVD+M ++A H + IYFIL + + +++L +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDA--HSFYNF--IYFILLIIVGSFFMINLCLV 392
Query: 597 VI 598
VI
Sbjct: 393 VI 394
Score = 35.8 bits (81), Expect = 0.37
Identities = 29/128 (22%), Positives = 52/128 (40%), Gaps = 18/128 (14%)
Query: 1371 NFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSF 1430
NF + G A +F+++T E W IM Y+ D ++ +YF
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIM----------------YFVMDAHSFYN-FIYFILL 378
Query: 1431 YVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRV 1490
++ ++ M+NL + +I FS E QL+ +R + G +
Sbjct: 379 IIVGSFFMINLCLVVIATQFS-ETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELL 437
Query: 1491 KFLLRLLR 1498
K+L+ +LR
Sbjct: 438 KYLVYILR 445
Score = 33.9 bits (76), Expect = 1.4
Identities = 29/132 (21%), Positives = 59/132 (44%), Gaps = 19/132 (14%)
Query: 415 YDEFYLAEVAFTVLFDLEALLKIWCLGFTG---YISSSLHKFELLLVIGTTLHVYPDLYH 471
+D+F A F +E ++K+ LG G Y+ + ++ + +VI L DL +
Sbjct: 120 FDDFIFA------FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQN 173
Query: 472 SQFTYFQ---VLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF 528
F+ + VLR +R I P++ V + LG++++ + + + +Q++
Sbjct: 174 VSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Query: 529 -------CFVEE 533
CF+ E
Sbjct: 234 AGLLRNRCFLPE 245
>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
isoform 7 [Homo sapiens]
Length = 2298
Score = 224 bits (570), Expect = 7e-58
Identities = 263/1148 (22%), Positives = 484/1148 (42%), Gaps = 141/1148 (12%)
Query: 378 QKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKI 437
+K++ S F I+ + V+ + Y+ E + ++ + FT LF LE LLK+
Sbjct: 737 RKIVDSKYFGRGIMIAILVNTLSMGIEYH--EQPEELTNALEISNIVFTSLFALEMLLKL 794
Query: 438 WCLGFTGYISSSLHKFELLLVIGTTLHVYPDLYH--SQFTYFQVLRVVRLIKISPALEDF 495
G GYI + + F+ ++V+ + + S F+++RV++L++ PAL+
Sbjct: 795 LVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQ 854
Query: 496 VYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF-C-FVEELD--------RFTTFPRAFM 545
+ + + + + + + S + + +F C F E D F + A +
Sbjct: 855 LVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIV 914
Query: 546 SMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVAVILDNLELD 605
++FQILTQE W V+ + + WA A+YFI F +L +L VA++++ + +
Sbjct: 915 TVFQILTQEDWNKVLYNGMASTSS-WA---ALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Query: 606 EDLKKLKQ---LKQSEANADTKEKLPLRLRIFEKFPNR------PQMVKISKLPSDFTVP 656
D K + + D K L L + P P ++ + P ++P
Sbjct: 971 GDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATP--MSLP 1028
Query: 657 KIRESFMKQFIDRQQQDTCCLLRSLPTT--------SSSSCDHSKRSAIEDNKYIDQKLR 708
K + + + + + T + P S+ S HS SA R
Sbjct: 1029 KSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS-----WTSR 1083
Query: 709 KSVFSIRARNLLEKETAVTKILRACTRQRMLSGSFEGQPAKERSILSVQHHIRQERRSLR 768
+S +RN L + ++ + + R+ +LSG EGQ +++ S + R
Sbjct: 1084 RS-----SRNSLGRAPSLKRRSPSGERRSLLSG--EGQESQDEEESSEEERASPAGSDHR 1136
Query: 769 HGSNSQRISRGKSLETLTQDHSNTVRYRNAQREDSEIKMIQEKKEQAEMKRKVQEEELRE 828
H + +R ++ T R + + SE + K + R ++ ++
Sbjct: 1137 HRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPL 1196
Query: 829 NHPYFDKPLFIVGREHRFRNFCRVVVRARFNASKTDPVTGAVKNTKYHQLYDLL--GLVT 886
+ D + E R +RAR A + + + + LL ++T
Sbjct: 1197 DGDDADDEGNLSKGER-----VRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIIT 1251
Query: 887 Y--LDWVMIIVTICSCISMMFESPFRRVMHAPT--LQIAEYVFVIFMSIELNLKIMADGL 942
+ D V++++ +CI++ E P A L ++ Y+F E+ +K++A G
Sbjct: 1252 HKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGW 1311
Query: 943 FFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLL------MVLRCLRPLRI 996
F A +R V+D + L+S+I + ++ ++SG ++L +LR LRPLR+
Sbjct: 1312 CFGEQAYLRSSWNVLDGLLVLISVIDIL---VSMVSDSGTKILGMLRVLRLLRTLRPLRV 1368
Query: 997 FKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDP---NIIR 1053
++ VV L S K I + ++ ++F GVQLF GK C NI
Sbjct: 1369 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1428
Query: 1054 REDC-NGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVL 1112
+ DC +R WV +NFDN+G A+++LF +
Sbjct: 1429 KSDCAEASYR----------------------WVRH------KYNFDNLGQALMSLFVLA 1460
Query: 1113 SLKGWVEVRDVIIHRVG----------PIHGIYIHVFVFLGCMIGLTLFVGVVIANFNEN 1162
S GWV++ + VG P +Y F+ + L +FVGVV+ NF++
Sbjct: 1461 SKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKC 1520
Query: 1163 KGTALLTVDQRRWEDLKSRLK---------IAQPLHLPPRPDNDGFRAKMYDITQHPFFK 1213
+ +RR E RL+ +A+ P D FR ++ + +
Sbjct: 1521 RQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLD 1580
Query: 1214 RTIALLVLAQSVLLSVK-WDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSR 1272
I ++ V ++++ + + L + +FT IFVLE K++A F+Q R
Sbjct: 1581 LFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDR 1640
Query: 1273 RNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACVIVFRFFSICGKHVTLKM------LLL 1326
N+ DL + L ++ + L +NA + + + R I LKM LL
Sbjct: 1641 WNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLD 1700
Query: 1327 TVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGEN-----INRHANFSSAGKAITV 1381
TV+ ++ + + + LL +A GV LFG ++ E + RHA F + G A
Sbjct: 1701 TVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLT 1760
Query: 1382 LFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNL 1441
LFR+ TG++WN IM D + C + + C N + +YF SF + ++++N+
Sbjct: 1761 LFRVSTGDNWNGIMKDTLRD---CDQE------STCYNTVISPIYFVSFVLTAQFVLVNV 1811
Query: 1442 LVAIIVEN 1449
++A+++++
Sbjct: 1812 VIAVLMKH 1819
Score = 134 bits (337), Expect = 8e-31
Identities = 136/650 (20%), Positives = 287/650 (44%), Gaps = 92/650 (14%)
Query: 34 NKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIR 93
+K + H +L + ++ I++ M P H ++T + + + ++ AEM K+
Sbjct: 1252 HKMFDHVVL-VIIFLNCITIAMERPKIDPHSAERIFLTLS-NYIFTAVFLAEMTVKVVAL 1309
Query: 94 GIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRA 153
G G+ +Y++ W V DG +V + +++ + ++D ++ GMLR+ R L +R
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM--VSDSGTKIL--GMLRVLRLLRTLRP 1365
Query: 154 FRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTK 213
R+ R + + + L S + I ++ + F +++GILGVQ+F + C DT+
Sbjct: 1366 LRVISRAQGLKL-VVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTR 1424
Query: 214 PGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTV 273
N+T S C+ E Y R F+ +G ++ ++
Sbjct: 1425 --NITNKS------DCA---EASY-----------------RWVRHKYNFDNLGQALMSL 1456
Query: 274 YEAASQEGWVFLMYRAID----------SFPRWRSYFYFITLIFFLAWLVKNVFIAVIIE 323
+ AS++GWV +MY +D + W YFI+ + +A+ V N+F+ V++E
Sbjct: 1457 FVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW-MLLYFISFLLIVAFFVLNMFVGVVVE 1515
Query: 324 TFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKP----QGRAPACLQK 379
F + R Q + + + + +A KP R +
Sbjct: 1516 NFHKCR---QHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHH 1572
Query: 380 MMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWC 439
+ S +FI ++ ++V+ A +Y+ + + FTV+F LE++ K+
Sbjct: 1573 LCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILD--EALKICNYIFTVIFVLESVFKLVA 1630
Query: 440 LGFTGYISSSLHKFELLLV-------------IGTTLHVYPDLYHSQFTYFQVLRVVRLI 486
GF + ++ +L +V + +L + P + ++ RV++L+
Sbjct: 1631 FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRI-MRVLRIARVLKLL 1689
Query: 487 KISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFV--------EELDR-- 536
K++ + + + ++G+L + L + +A+ +++F + E L R
Sbjct: 1690 KMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHA 1749
Query: 537 -FTTFPRAFMSMFQILTQEGWVDVMDQTL---NAVGHMWAPVVA-IYFILYHLFATLILL 591
F F AF+++F++ T + W +M TL + + V++ IYF+ + L A +L+
Sbjct: 1750 TFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLV 1809
Query: 592 SLFVAVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRP 641
++ +AV++ +LE + K+++ A+ + +L L ++ P+ P
Sbjct: 1810 NVVIAVLMKHLE--------ESNKEAKEEAELEAELELEMKTLSPQPHSP 1851
Score = 81.3 bits (199), Expect = 8e-15
Identities = 59/249 (23%), Positives = 118/249 (47%), Gaps = 24/249 (9%)
Query: 1206 ITQHPFFKRTIALLVLAQSVLLSVKWDVE-DPVTVPLATMSVVFTFIFVLEVTMKIIAMS 1264
I +F R I + +L ++ + +++ + + +T L ++VFT +F LE+ +K++
Sbjct: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
Query: 1265 PAGFWQSRRNRYDLLVTSLGVVWVVLHF---ALLNAYTYMMGACVIVFRFFSICGKHVTL 1321
P G+ ++ N +D ++ + V W ++ L T+ + + + RF + + +
Sbjct: 799 PFGYIKNPYNIFDGVIVVISV-WEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVV 857
Query: 1322 KMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAITV 1381
M + V + + + +F +L + F F + + G+ + NF S AI
Sbjct: 858 LMKTMDNVATFCMLLMLFIFIFSILGMHLFG--CKFASERDGDTLPDRKNFDSLLWAIVT 915
Query: 1382 LFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNL 1441
+F+I+T EDWNK++++ M + WA +YF + Y++ NL
Sbjct: 916 VFQILTQEDWNKVLYNGMAST--------SSWAA---------LYFIALMTFGNYVLFNL 958
Query: 1442 LVAIIVENF 1450
LVAI+VE F
Sbjct: 959 LVAILVEGF 967
Score = 80.9 bits (198), Expect = 1e-14
Identities = 73/314 (23%), Positives = 133/314 (42%), Gaps = 55/314 (17%)
Query: 369 PQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVL 428
PQ R +++ +F +L ++ ++ I A K + + L+ FT +
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297
Query: 429 FDLEALLKI----WCLGFTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFT--------- 475
F E +K+ WC G Y+ SS + + LLV+ + + + + T
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357
Query: 476 -YFQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF------ 528
+ LR +R+I + L+ V + K +G++VV + I+ + +Q+F
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417
Query: 529 --------------C------FVEELDRFTTFPRAFMSMFQILTQEGWVDVMDQTLNAVG 568
C +V F +A MS+F + +++GWVD+M L+AVG
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1477
Query: 569 HMWAPV------VAIYFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSEANAD 622
P+ + +YFI + L +L++FV V+++N K +Q ++ E
Sbjct: 1478 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFH------KCRQHQEEEEARR 1531
Query: 623 TKEKLPLRLRIFEK 636
+EK RLR EK
Sbjct: 1532 REEK---RLRRLEK 1542
Score = 68.2 bits (165), Expect = 7e-11
Identities = 66/304 (21%), Positives = 134/304 (44%), Gaps = 50/304 (16%)
Query: 1194 PDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVP---LATMSVVFTF 1250
P FR + I H F + +++ + ++++ DP + L + +FT
Sbjct: 1237 PPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTA 1296
Query: 1251 IFVLEVTMKIIAMS----PAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACV 1306
+F+ E+T+K++A+ + +S N D L+ + V+ +++ + ++ T ++G
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM-VSDSGTKILGMLR 1355
Query: 1307 IV-----FRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGT-- 1359
++ R + + LK+++ T++ S+ I+V + + GV LF
Sbjct: 1356 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1415
Query: 1360 -VKYGENIN----------------RHA-NFSSAGKAITVLFRIVTGEDWNKIMHDCMV- 1400
V GE+ RH NF + G+A+ LF + + + W IM+D +
Sbjct: 1416 FVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDA 1475
Query: 1401 ----QPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYST 1456
Q P + + L+YF SF +I+A+ +LN+ V ++VENF
Sbjct: 1476 VGVDQQPIMNHNPWM------------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH 1523
Query: 1457 EEDQ 1460
+E++
Sbjct: 1524 QEEE 1527
Score = 62.0 bits (149), Expect = 5e-09
Identities = 59/277 (21%), Positives = 123/277 (44%), Gaps = 60/277 (21%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWC 108
+I++ +NT M E++ + +T L+ + ++T+ +M ++ +V G Y+K+ +
Sbjct: 750 MIAILVNTLSMGIEYHEQPEELTNALE-ISNIVFTSLFALEMLLKLLVYGPFGYIKNPYN 808
Query: 109 VFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRIT 168
+FDG +V V + +IV Q G L + R ++R ++ RF R
Sbjct: 809 IFDGVIV----------VISVWEIVGQQG--GGLSVLRTFRLMRVLKLV-RFLPALQRQL 855
Query: 169 NILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTH 228
+L ++ + + + + L+ F+ ++ ILG+ +FG C + G+ +PD
Sbjct: 856 VVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-----CKFASERDGD------TLPDR- 903
Query: 229 CSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYR 288
F+ + +I TV++ +QE W ++Y
Sbjct: 904 --------------------------------KNFDSLLWAIVTVFQILTQEDWNKVLYN 931
Query: 289 AIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETF 325
+ S W + YFI L+ F +++ N+ +A+++E F
Sbjct: 932 GMASTSSWAA-LYFIALMTFGNYVLFNLLVAILVEGF 967
Score = 53.1 bits (126), Expect = 2e-06
Identities = 72/346 (20%), Positives = 128/346 (36%), Gaps = 61/346 (17%)
Query: 32 WINKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMH 91
W + + +L C + + C + + LQ D + + EM+ KM
Sbjct: 82 WFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQ----AFDDFIFAFFAVEMVVKMV 137
Query: 92 IRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMI 151
GI G Y+ D W D F+V + L + ++ S +R+ RPL I
Sbjct: 138 ALGIF-GKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-----FSAVRTVRVLRPLRAI 191
Query: 152 RAFRIYFRFELPRTRI-TNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF-GTFTYHCVV 209
+P RI +L + + +V + F ++GI+GVQ++ G C +
Sbjct: 192 N--------RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL 243
Query: 210 --NDTKPGNVTWNSLAIPDTH------CSPELEEG------------------------- 236
N + P +V + CS E G
Sbjct: 244 PENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYE 303
Query: 237 -YQCPPGFKCMDLEDL------GLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRA 289
Y C++ G G F+ IG + +++ + EGWV +MY
Sbjct: 304 AYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFV 363
Query: 290 IDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQM 335
+D+ + ++ YFI LI ++ + N+ + VI F+E + + Q+
Sbjct: 364 MDAH-SFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQL 408
Score = 50.8 bits (120), Expect = 1e-05
Identities = 40/161 (24%), Positives = 73/161 (45%), Gaps = 9/161 (5%)
Query: 887 YLDWVMIIVTICSCISMMFESPFRRV----MHAPTLQIAEYVFVIFMSIELNLKIMADGL 942
+ + + ++V + +C+++ P + LQ + F ++E+ +K++A G+
Sbjct: 82 WFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGI 141
Query: 943 FFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQ 1002
F + D +D FI + ++ QNV + + +R LRPLR VP
Sbjct: 142 F-GKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSA----VRTVRVLRPLRAINRVPS 196
Query: 1003 MRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKL 1043
MR +V L + V +L + +F GVQL+AG L
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLL 237
Score = 48.9 bits (115), Expect = 4e-05
Identities = 21/67 (31%), Positives = 40/67 (59%)
Query: 1097 NFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVGPIHGIYIHVFVFLGCMIGLTLFVGVVI 1156
NFDN+G A +A+F+V++L+GWV++ ++ + IY + + +G + L + V+
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
Query: 1157 ANFNENK 1163
F+E K
Sbjct: 396 TQFSETK 402
Score = 37.4 bits (85), Expect = 0.13
Identities = 21/62 (33%), Positives = 37/62 (59%), Gaps = 4/62 (6%)
Query: 537 FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVA 596
F A++++FQ++T EGWVD+M ++A H + IYFIL + + +++L +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDA--HSFYNF--IYFILLIIVGSFFMINLCLV 392
Query: 597 VI 598
VI
Sbjct: 393 VI 394
Score = 35.8 bits (81), Expect = 0.37
Identities = 29/128 (22%), Positives = 52/128 (40%), Gaps = 18/128 (14%)
Query: 1371 NFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSF 1430
NF + G A +F+++T E W IM Y+ D ++ +YF
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIM----------------YFVMDAHSFYN-FIYFILL 378
Query: 1431 YVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRV 1490
++ ++ M+NL + +I FS E QL+ +R + G +
Sbjct: 379 IIVGSFFMINLCLVVIATQFS-ETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELL 437
Query: 1491 KFLLRLLR 1498
K+L+ +LR
Sbjct: 438 KYLVYILR 445
Score = 33.9 bits (76), Expect = 1.4
Identities = 29/132 (21%), Positives = 59/132 (44%), Gaps = 19/132 (14%)
Query: 415 YDEFYLAEVAFTVLFDLEALLKIWCLGFTG---YISSSLHKFELLLVIGTTLHVYPDLYH 471
+D+F A F +E ++K+ LG G Y+ + ++ + +VI L DL +
Sbjct: 120 FDDFIFA------FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQN 173
Query: 472 SQFTYFQ---VLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF 528
F+ + VLR +R I P++ V + LG++++ + + + +Q++
Sbjct: 174 VSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Query: 529 -------CFVEE 533
CF+ E
Sbjct: 234 AGLLRNRCFLPE 245
>gi|193788548 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 20 [Homo sapiens]
Length = 2127
Score = 222 bits (565), Expect = 3e-57
Identities = 189/703 (26%), Positives = 337/703 (47%), Gaps = 55/703 (7%)
Query: 891 VMIIVTICSCISMMFESPFRRV-MHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
+++ + S IS+ E P + L A+YVF ++E+ LK+ A G F +
Sbjct: 905 LILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSF 964
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRE 1009
R++ ++D+ + VSLI + ++L VLR LRPLR ++ VV+
Sbjct: 965 CRNYFNILDLLVVSVSLISFGIQSSAINV---VKILRVLRVLRPLRAINRAKGLKHVVQC 1021
Query: 1010 LFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSK 1069
+F + I + I+ L +FA GVQLF GKL C+D + +C G +
Sbjct: 1022 VFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNY-------- 1073
Query: 1070 NLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEV--RDVIIHR 1127
+ + GE PR W N + F+FDNV AM+ALF V + +GW E+ R + H
Sbjct: 1074 ---ITYKDGEVDHPIIQPRSWENSK-FDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHT 1129
Query: 1128 --VGPIH------GIYIHVFVFLGCMIGLTLFVGVVIANFNE--NKGTALLTVDQRRWED 1177
GPI+ I+ +++ + + +FVG VI F E + +D+ + +
Sbjct: 1130 EDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQC 1189
Query: 1178 LKSRLKIAQPL--HLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVK-WDVE 1234
++ LK A+PL ++P + + K++ + +F+ + +L+L ++ L+++ +
Sbjct: 1190 VEYALK-ARPLRRYIP----KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQS 1244
Query: 1235 DPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFAL 1294
+ + ++++FT +F +E+ +K+IA P ++ N +D L+ +V + +
Sbjct: 1245 CLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAI--TE 1302
Query: 1295 LNAYTYMMGACVIVFRFF------SICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLC 1348
+N + FR F + + ++ LL T + S ++ + + +L
Sbjct: 1303 VNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFI 1362
Query: 1349 YAFAGVVLFGTVKYGE--NINRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQ---PP 1403
YA G+ +FG + + INR+ NF + +A+ +LFR TGE W IM CM P
Sbjct: 1363 YAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAP 1422
Query: 1404 FCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLS 1463
P T T CG+ + A+ YF SFY++ A++++NL VA+I++NF Y T + +L
Sbjct: 1423 ESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFD--YLTRDWSILG 1479
Query: 1464 YNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEV-DLDKDKLLFKHMCYEMERL 1522
+ L F+ IW D + +G I V LLR ++ L L ++ K + L
Sbjct: 1480 PHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPL 1539
Query: 1523 HNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEE 1565
++ G V F+ L L ++ I+ LE+ A E+L I++
Sbjct: 1540 NSDGTVMFNATLFALVRTALRIKTEGNLEQ--ANEELRAIIKK 1580
Score = 147 bits (370), Expect = 1e-34
Identities = 149/687 (21%), Positives = 296/687 (43%), Gaps = 102/687 (14%)
Query: 74 LDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIV 133
++ L + ++T E K+ G++ ++Y+++ W + D +V V L + E A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVV---VGLFSAILEQATKA 218
Query: 134 DQMSPWGMLRIPRPLIMIRAFRIYFRFEL----PRTRIT-NILKRSGEQIWSVSIFLLFF 188
D + G + +RAFR+ L P ++ N + ++ + +++ +LF
Sbjct: 219 DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 278
Query: 189 LLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDL 248
+++Y I+G+++F + N +V P C+ E G QC G C
Sbjct: 279 IIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSP---CALETGHGRQCQNGTVCKP- 334
Query: 249 EDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFF 308
G + G + F+ ++ TV++ + EGW ++Y D+ R + YF+TLI
Sbjct: 335 ---GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIII 391
Query: 309 LAWLVKNVFIAVIIETF------AEIRVQFQQM---------------WGSRS------- 340
++ V N+ + V+ F A+ R FQ++ W +++
Sbjct: 392 GSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPEN 451
Query: 341 -------------STTSTATTQMFHEDAAGG-------WQLVAVDVNKPQGRA------P 374
S ++ T + E+ AGG +A ++K +
Sbjct: 452 EDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNR 511
Query: 375 ACLQKM---MRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDL 431
C +K ++S+VF+ ++ +V ++ + AS +Y N+ + + A A LF
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD--TANKALLALFTA 569
Query: 432 EALLKIWCLGFTGYISSSLHKFELLLVIGTTLH-------VYPDLYHSQFTYFQVLRVVR 484
E LLK++ LG Y S ++F+ +V G L + L S ++LR+ +
Sbjct: 570 EMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFK 629
Query: 485 LIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR-------F 537
+ + +L + V + + + SL++ +I+ S + +Q+F D F
Sbjct: 630 ITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTF 689
Query: 538 TTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP--VVAIYFILYHLFATLILLSLFV 595
FP++ +++FQILT E W VM + A G P +V IYFI+ + ILL++F+
Sbjct: 690 DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFL 749
Query: 596 AVILDNLELDEDLKKLKQLKQSE---------ANADTKEKLPLRLRIFEKFPNRPQMVKI 646
A+ +DNL E L ++ ++ E A+ + K++L + + E ++ + +++
Sbjct: 750 AIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE---SKEEKIEL 806
Query: 647 SKLPSDFTVPKIRESFMKQFIDRQQQD 673
+ +D P + M + +D
Sbjct: 807 KSITADGESPPATKINMDDLQPNENED 833
Score = 104 bits (260), Expect = 7e-22
Identities = 94/357 (26%), Positives = 164/357 (45%), Gaps = 62/357 (17%)
Query: 885 VTYLDW----VMIIVTI-CSCISMMFESPFRRVMHAPT---LQIAEYVFVIFMSIELNLK 936
++ ++W ++I++TI +C+++ PF T L+ EY+F+I ++E LK
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 937 IMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQL-----------L 985
++A GL F P A +R+ ++D I +V L F + Q A+ L L
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGL-FSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 986 MVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAK 1045
R LRPLR+ VP ++ V+ + + +++L+L +++++A G++LF GK+ K
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 1046 C-------------NDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWAN 1092
+DP+ E +G N +V K PG W
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCK-------PG-----------WDG 338
Query: 1093 PRN--FNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVG-PIHGIYIHVFVFLGCMIGLT 1149
P++ NFDN AML +F+ ++++GW +V + VG IY + +G L
Sbjct: 339 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLN 398
Query: 1150 LFVGVVIANFNENKGTALLTVD-------QRRWEDLKSRLK-IAQPLHLPPRPDNDG 1198
L +GV+ F++ + A D Q+ EDLK L I Q + P +++G
Sbjct: 399 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEG 455
Score = 98.6 bits (244), Expect = 5e-20
Identities = 125/615 (20%), Positives = 257/615 (41%), Gaps = 86/615 (13%)
Query: 33 INKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHI 92
+N +L+ ++S IS+ P+ +H ++ D + ++T E+I KM
Sbjct: 897 VNDTIFTNLILFFILLSSISLAAEDPV--QHTSFRNHILGNADYVFTSIFTLEIILKMTA 954
Query: 93 RGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIR 152
G S+ ++ + + D L VS+ L F I Q S +++I R L ++R
Sbjct: 955 YGAFLHKGSFCRNYFNILD-----LLVVSVSLISFGI-----QSSAINVVKILRVLRVLR 1004
Query: 153 AFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDT 212
R R + + + + + I ++ I ++ +GVQ+F Y C + +
Sbjct: 1005 PLRAINRAKGLK-HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS-DSS 1062
Query: 213 KPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFT 272
K I T+ E++ P ++ + F+ + ++
Sbjct: 1063 KQTEAECKGNYI--TYKDGEVDHPIIQPRSWENSKFD-------------FDNVLAAMMA 1107
Query: 273 VYEAASQEGWVFLMYRAIDSFPRWRSYFY---------FITLIFFLAWLVKNVFIAVIIE 323
++ ++ EGW L+YR+IDS + Y FI I +A+ + N+F+ +I
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 324 TFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPACLQKMMRS 383
TF E Q +Q + + + + A + + P+ + + ++ S
Sbjct: 1168 TFQE---QGEQEYKNCELDKNQRQCVEYALKARPLRRYI------PKNQHQYKVWYVVNS 1218
Query: 384 SVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFT 443
+ F + ++ ++ I A +Y G++ + + + FT LF +E +LK+
Sbjct: 1219 TYFEYLMFVLILLNTICLAMQHY-GQSCLFKI-AMNILNMLFTGLFTVEMILKLIAFKPK 1276
Query: 444 GYISSSLHKFELLLVIGTTLHVYPDLYHS-------QFTYFQVLRVVRLIKI---SPALE 493
Y + + F+ L+V+G+ + + ++ T+F++ RV+RL+K+ +
Sbjct: 1277 HYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIR 1336
Query: 494 DFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVE-----ELDR---FTTFPRAFM 545
++ + L + + L + + I +Q+F + E++R F TFP+A +
Sbjct: 1337 TLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVL 1396
Query: 546 SMFQILTQEGWVDVMDQTLNAVGHMWAP-----------------VVAIYFILYHLFATL 588
+F+ T E W D+M + G AP YFI +++
Sbjct: 1397 LLFRCATGEAWQDIMLACMP--GKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAF 1454
Query: 589 ILLSLFVAVILDNLE 603
++++LFVAVI+DN +
Sbjct: 1455 LIINLFVAVIMDNFD 1469
Score = 78.2 bits (191), Expect = 7e-14
Identities = 57/250 (22%), Positives = 122/250 (48%), Gaps = 17/250 (6%)
Query: 1206 ITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSP 1265
+ + F+ I L+ L + S ++ + +T T + +F E+ +K+ ++
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1266 AGFWQSRRNRYDLLVTSLGVVWVVL-HFALLNAYTYMMGACVIVFRFFSICGKHVTLKML 1324
++ S NR+D V G++ +L +++ + CV + R F I +L L
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1325 LLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFG-TVKYGENINRHANFSSAGKAITVLF 1383
+ +++ S+ +++ +FL ++ ++ G+ LFG + E R + F + +++ +F
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVF 700
Query: 1384 RIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGAL--MYFCSFYVIIAYIMLNL 1441
+I+TGEDWN +M+D ++ A ++ G L +YF ++ YI+LN+
Sbjct: 701 QILTGEDWNSVMYDGIM-------------AYGGPSFPGMLVCIYFIILFICGNYILLNV 747
Query: 1442 LVAIIVENFS 1451
+AI V+N +
Sbjct: 748 FLAIAVDNLA 757
Score = 58.9 bits (141), Expect = 4e-08
Identities = 68/287 (23%), Positives = 120/287 (41%), Gaps = 68/287 (23%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDTL---LMFLYTAEMIAKMHIRGIVKGDSSYVKD 105
+ V +NT + EHY ++T DT L+ L+TAEM+ KM+ G+ +Y
Sbjct: 531 IFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL----QAYFVS 586
Query: 106 RWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRT 165
+ FD F+V + +L +I MSP G + + R + ++R F+I R+ +
Sbjct: 587 LFNRFDCFVVCGGILETILVETKI------MSPLG-ISVLRCVRLLRIFKIT-RYWNSLS 638
Query: 166 RITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIP 225
+ L S I S+ + L F++++ +LG+Q+FG G ++ +
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFG-------------GKFNFDEM--- 682
Query: 226 DTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFL 285
+ S F+ S+ TV++ + E W +
Sbjct: 683 -------------------------------QTRRSTFDNFPQSLLTVFQILTGEDWNSV 711
Query: 286 MYRAI-----DSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAE 327
MY I SFP YFI L +++ NVF+A+ ++ A+
Sbjct: 712 MYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLAD 758
Score = 51.2 bits (121), Expect = 9e-06
Identities = 64/306 (20%), Positives = 120/306 (39%), Gaps = 62/306 (20%)
Query: 890 WVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
W++I + + +++ E + A + + E+ LK+ + GL ++
Sbjct: 528 WLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSL 587
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVP---QMRKV 1006
F D F+ ++ + + + G + VLRC+R LRIFK+ + +
Sbjct: 588 FNRF----DCFVVCGGILETILVETKIMSPLG---ISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1007 VRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVS 1066
V L + + I + +LL +++F+ G+QLF GK F +
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGK------------------FNFDE- 681
Query: 1067 VSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVR-DVII 1125
R FDN ++L +F++L+ + W V D I+
Sbjct: 682 ------------------------MQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIM 717
Query: 1126 HRVGP-----IHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKS 1180
GP + IY + G I L +F+ + + N + + LT Q+ E+ K
Sbjct: 718 AYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAES---LTSAQKEEEEEKE 774
Query: 1181 RLKIAQ 1186
R K+A+
Sbjct: 775 RKKLAR 780
Score = 48.9 bits (115), Expect = 4e-05
Identities = 57/275 (20%), Positives = 117/275 (42%), Gaps = 57/275 (20%)
Query: 379 KMMRSSVFHMFILSMVTVDVI-VAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKI 437
+++ ++F IL + + I +AA + + +FR A+ FT +F LE +LK+
Sbjct: 895 RIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHI--LGNADYVFTSIFTLEIILKM 952
Query: 438 WCLG---FTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFTYFQVLRVVRL------IKI 488
G G + LLV+ +L + + S ++LRV+R+ I
Sbjct: 953 TAYGAFLHKGSFCRNYFNILDLLVVSVSLISF-GIQSSAINVVKILRVLRVLRPLRAINR 1011
Query: 489 SPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF------CFVE---------- 532
+ L+ V +F + +G++V+ T L + + I +Q+F C
Sbjct: 1012 AKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKG 1071
Query: 533 --------ELDRFTTFPR--------------AFMSMFQILTQEGWVDVMDQTLNAVGHM 570
E+D PR A M++F + T EGW +++ +++++
Sbjct: 1072 NYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTED 1131
Query: 571 WAPV------VAIYFILYHLFATLILLSLFVAVIL 599
P+ ++I+FI+Y + ++++FV ++
Sbjct: 1132 KGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
Score = 41.6 bits (96), Expect = 0.007
Identities = 57/300 (19%), Positives = 110/300 (36%), Gaps = 76/300 (25%)
Query: 1212 FKRTIALLVLAQSVLLSV----KWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMS--- 1264
F+ I L + A V L++ D + L + +F IF +E +K+IA
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLF 185
Query: 1265 -PAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGA-----------CVIVFRFF 1312
P + ++ N D ++ +G+ +L A +G V R
Sbjct: 186 HPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPL 245
Query: 1313 SICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLF--------------- 1357
+ +L+++L +++ +M I + + +++ YA G+ LF
Sbjct: 246 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIA 305
Query: 1358 -----------------------GTV-KYGENINRHA--NFSSAGKAITVLFRIVTGEDW 1391
GTV K G + +H NF + A+ +F+ +T E W
Sbjct: 306 DVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGW 365
Query: 1392 NKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFS 1451
++ YW D +YF + +I ++ +LNL++ ++ FS
Sbjct: 366 TDVL----------------YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS 409
>gi|38505286 voltage-dependent calcium channel alpha 1G subunit
isoform 10 [Homo sapiens]
Length = 2266
Score = 221 bits (563), Expect = 5e-57
Identities = 265/1152 (23%), Positives = 481/1152 (41%), Gaps = 133/1152 (11%)
Query: 378 QKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKI 437
+K++ S F I+ + V+ + Y+ E + ++ + FT LF LE LLK+
Sbjct: 737 RKIVDSKYFGRGIMIAILVNTLSMGIEYH--EQPEELTNALEISNIVFTSLFALEMLLKL 794
Query: 438 WCLGFTGYISSSLHKFELLLVIGTTLHVYPDLYH--SQFTYFQVLRVVRLIKISPALEDF 495
G GYI + + F+ ++V+ + + S F+++RV++L++ PAL+
Sbjct: 795 LVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQ 854
Query: 496 VYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF-C-FVEELD--------RFTTFPRAFM 545
+ + + + + + + S + + +F C F E D F + A +
Sbjct: 855 LVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIV 914
Query: 546 SMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVAVILDNLELD 605
++FQILTQE W V+ + + WA A+YFI F +L +L VA++++ + +
Sbjct: 915 TVFQILTQEDWNKVLYNGMASTSS-WA---ALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Query: 606 EDLKKLK--------QLKQSEANADTKEKLPLRLRIFEKFPNRPQMVKISKLPSDFTVPK 657
E K+ QL D + K L S P+
Sbjct: 971 EISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPE 1030
Query: 658 IRESFMKQFIDRQQQDTCCLLRSLPT-------------TSSSSCD----HSKRS--AIE 698
+R+S + I L +S T +SS S + H +S +
Sbjct: 1031 LRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR 1090
Query: 699 DNKYIDQKLRKSVFSIRA-RNLLEKETAVTKILRACTRQRMLSGSFEGQPAKERSILSVQ 757
+ + S S R+ RN L + ++ + + R+ +LSG EGQ +++ S +
Sbjct: 1091 SSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSG--EGQESQDEEESSEE 1148
Query: 758 HHIRQERRSLRHGSNSQRISRGKSLETLTQDHSNTVRYRNAQREDSEIKMIQEKKEQAEM 817
RH + +R ++ T R + + SE + K +
Sbjct: 1149 ERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRL 1208
Query: 818 KRKVQEEELRENHPYFDKPLFIVGREHRFRNFCRVVVRARFNASKTDPVTGAVKNTKYHQ 877
R ++ ++ + D + E R +RAR A + + +
Sbjct: 1209 ARALRPDDPPLDGDDADDEGNLSKGER-----VRAWIRARLPACCLERDSWSAYIFPPQS 1263
Query: 878 LYDLL--GLVTY--LDWVMIIVTICSCISMMFESPFRRVMHAPT--LQIAEYVFVIFMSI 931
+ LL ++T+ D V++++ +CI++ E P A L ++ Y+F
Sbjct: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323
Query: 932 ELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLL------ 985
E+ +K++A G F A +R V+D + L+S+I + ++ ++SG ++L
Sbjct: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDIL---VSMVSDSGTKILGMLRVL 1380
Query: 986 MVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAK 1045
+LR LRPLR+ ++ VV L S K I + ++ ++F GVQLF GK
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Query: 1046 CNDP---NIIRREDC-NGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNV 1101
C NI + DC +R WV +NFDN+
Sbjct: 1441 CQGEDTRNITNKSDCAEASYR----------------------WVRH------KYNFDNL 1472
Query: 1102 GNAMLALFEVLSLKGWVEVRDVIIHRVG----------PIHGIYIHVFVFLGCMIGLTLF 1151
G A+++LF + S GWV++ + VG P +Y F+ + L +F
Sbjct: 1473 GQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMF 1532
Query: 1152 VGVVIANFNENKGTALLTVDQRRWEDLKSRL--KIAQPLHLPPRPDNDGFRAKMYDITQH 1209
VGVV+ NF++ + +RR E RL K + P D FR ++ +
Sbjct: 1533 VGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRKAQCKPYYSDYSRFRLLVHHLCTS 1592
Query: 1210 PFFKRTIALLVLAQSVLLSVK-WDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGF 1268
+ I ++ V ++++ + + L + +FT IFVLE K++A F
Sbjct: 1593 HYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRF 1652
Query: 1269 WQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACVIVFRFFSICGKHVTLKM----- 1323
+Q R N+ DL + L ++ + L +NA + + + R I LKM
Sbjct: 1653 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1712
Query: 1324 -LLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGEN-----INRHANFSSAGK 1377
LL TV+ ++ + + + LL +A GV LFG ++ E + RHA F + G
Sbjct: 1713 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGM 1772
Query: 1378 AITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYI 1437
A LFR+ TG++WN IM D + C + + C N + +YF SF + ++
Sbjct: 1773 AFLTLFRVSTGDNWNGIMKDTLRD---CDQE------STCYNTVISPIYFVSFVLTAQFV 1823
Query: 1438 MLNLLVAIIVEN 1449
++N+++A+++++
Sbjct: 1824 LVNVVIAVLMKH 1835
Score = 134 bits (338), Expect = 6e-31
Identities = 134/646 (20%), Positives = 283/646 (43%), Gaps = 91/646 (14%)
Query: 34 NKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIR 93
+K + H +L + ++ I++ M P H ++T + + + ++ AEM K+
Sbjct: 1275 HKMFDHVVL-VIIFLNCITIAMERPKIDPHSAERIFLTLS-NYIFTAVFLAEMTVKVVAL 1332
Query: 94 GIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRA 153
G G+ +Y++ W V DG +V + +++ + ++D ++ GMLR+ R L +R
Sbjct: 1333 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM--VSDSGTKIL--GMLRVLRLLRTLRP 1388
Query: 154 FRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTK 213
R+ R + + + L S + I ++ + F +++GILGVQ+F + C DT+
Sbjct: 1389 LRVISRAQGLKL-VVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTR 1447
Query: 214 PGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTV 273
N+T S C+ E Y R F+ +G ++ ++
Sbjct: 1448 --NITNKS------DCA---EASY-----------------RWVRHKYNFDNLGQALMSL 1479
Query: 274 YEAASQEGWVFLMYRAID----------SFPRWRSYFYFITLIFFLAWLVKNVFIAVIIE 323
+ AS++GWV +MY +D + W YFI+ + +A+ V N+F+ V++E
Sbjct: 1480 FVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW-MLLYFISFLLIVAFFVLNMFVGVVVE 1538
Query: 324 TFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPACLQKMMRS 383
F + R ++ R + A R + + S
Sbjct: 1539 NFHKCRQHQEEEEARRREEKRLRRLEKKRRKAQ------CKPYYSDYSRFRLLVHHLCTS 1592
Query: 384 SVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFT 443
+FI ++ ++V+ A +Y+ + + FTV+F LE++ K+ GF
Sbjct: 1593 HYLDLFITGVIGLNVVTMAMEHYQQPQILD--EALKICNYIFTVIFVLESVFKLVAFGFR 1650
Query: 444 GYISSSLHKFELLLV-------------IGTTLHVYPDLYHSQFTYFQVLRVVRLIKISP 490
+ ++ +L +V + +L + P + ++ RV++L+K++
Sbjct: 1651 RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRI-MRVLRIARVLKLLKMAV 1709
Query: 491 ALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFV--------EELDR---FTT 539
+ + + ++G+L + L + +A+ +++F + E L R F
Sbjct: 1710 GMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRN 1769
Query: 540 FPRAFMSMFQILTQEGWVDVMDQTL---NAVGHMWAPVVA-IYFILYHLFATLILLSLFV 595
F AF+++F++ T + W +M TL + + V++ IYF+ + L A +L+++ +
Sbjct: 1770 FGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVI 1829
Query: 596 AVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRP 641
AV++ +LE + K+++ A+ + +L L ++ P+ P
Sbjct: 1830 AVLMKHLE--------ESNKEAKEEAELEAELELEMKTLSPQPHSP 1867
Score = 81.3 bits (199), Expect = 8e-15
Identities = 59/249 (23%), Positives = 118/249 (47%), Gaps = 24/249 (9%)
Query: 1206 ITQHPFFKRTIALLVLAQSVLLSVKWDVE-DPVTVPLATMSVVFTFIFVLEVTMKIIAMS 1264
I +F R I + +L ++ + +++ + + +T L ++VFT +F LE+ +K++
Sbjct: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
Query: 1265 PAGFWQSRRNRYDLLVTSLGVVWVVLHF---ALLNAYTYMMGACVIVFRFFSICGKHVTL 1321
P G+ ++ N +D ++ + V W ++ L T+ + + + RF + + +
Sbjct: 799 PFGYIKNPYNIFDGVIVVISV-WEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVV 857
Query: 1322 KMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAITV 1381
M + V + + + +F +L + F F + + G+ + NF S AI
Sbjct: 858 LMKTMDNVATFCMLLMLFIFIFSILGMHLFG--CKFASERDGDTLPDRKNFDSLLWAIVT 915
Query: 1382 LFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNL 1441
+F+I+T EDWNK++++ M + WA +YF + Y++ NL
Sbjct: 916 VFQILTQEDWNKVLYNGMAST--------SSWAA---------LYFIALMTFGNYVLFNL 958
Query: 1442 LVAIIVENF 1450
LVAI+VE F
Sbjct: 959 LVAILVEGF 967
Score = 81.3 bits (199), Expect = 8e-15
Identities = 74/320 (23%), Positives = 135/320 (42%), Gaps = 55/320 (17%)
Query: 369 PQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVL 428
PQ R +++ +F +L ++ ++ I A K + + L+ FT +
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
Query: 429 FDLEALLKI----WCLGFTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFT--------- 475
F E +K+ WC G Y+ SS + + LLV+ + + + + T
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
Query: 476 -YFQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF------ 528
+ LR +R+I + L+ V + K +G++VV + I+ + +Q+F
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Query: 529 --------------C------FVEELDRFTTFPRAFMSMFQILTQEGWVDVMDQTLNAVG 568
C +V F +A MS+F + +++GWVD+M L+AVG
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 569 HMWAPV------VAIYFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSEANAD 622
P+ + +YFI + L +L++FV V+++N K +Q ++ E
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFH------KCRQHQEEEEARR 1554
Query: 623 TKEKLPLRLRIFEKFPNRPQ 642
+EK RLR EK + Q
Sbjct: 1555 REEK---RLRRLEKKRRKAQ 1571
Score = 68.2 bits (165), Expect = 7e-11
Identities = 66/304 (21%), Positives = 134/304 (44%), Gaps = 50/304 (16%)
Query: 1194 PDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVP---LATMSVVFTF 1250
P FR + I H F + +++ + ++++ DP + L + +FT
Sbjct: 1260 PPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTA 1319
Query: 1251 IFVLEVTMKIIAMS----PAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACV 1306
+F+ E+T+K++A+ + +S N D L+ + V+ +++ + ++ T ++G
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM-VSDSGTKILGMLR 1378
Query: 1307 IV-----FRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGT-- 1359
++ R + + LK+++ T++ S+ I+V + + GV LF
Sbjct: 1379 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1438
Query: 1360 -VKYGENIN----------------RHA-NFSSAGKAITVLFRIVTGEDWNKIMHDCMV- 1400
V GE+ RH NF + G+A+ LF + + + W IM+D +
Sbjct: 1439 FVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDA 1498
Query: 1401 ----QPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYST 1456
Q P + + L+YF SF +I+A+ +LN+ V ++VENF
Sbjct: 1499 VGVDQQPIMNHNPWM------------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH 1546
Query: 1457 EEDQ 1460
+E++
Sbjct: 1547 QEEE 1550
Score = 62.0 bits (149), Expect = 5e-09
Identities = 59/277 (21%), Positives = 123/277 (44%), Gaps = 60/277 (21%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWC 108
+I++ +NT M E++ + +T L+ + ++T+ +M ++ +V G Y+K+ +
Sbjct: 750 MIAILVNTLSMGIEYHEQPEELTNALE-ISNIVFTSLFALEMLLKLLVYGPFGYIKNPYN 808
Query: 109 VFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRIT 168
+FDG +V V + +IV Q G L + R ++R ++ RF R
Sbjct: 809 IFDGVIV----------VISVWEIVGQQG--GGLSVLRTFRLMRVLKLV-RFLPALQRQL 855
Query: 169 NILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTH 228
+L ++ + + + + L+ F+ ++ ILG+ +FG C + G+ +PD
Sbjct: 856 VVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-----CKFASERDGD------TLPDR- 903
Query: 229 CSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYR 288
F+ + +I TV++ +QE W ++Y
Sbjct: 904 --------------------------------KNFDSLLWAIVTVFQILTQEDWNKVLYN 931
Query: 289 AIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETF 325
+ S W + YFI L+ F +++ N+ +A+++E F
Sbjct: 932 GMASTSSWAA-LYFIALMTFGNYVLFNLLVAILVEGF 967
Score = 53.1 bits (126), Expect = 2e-06
Identities = 72/346 (20%), Positives = 128/346 (36%), Gaps = 61/346 (17%)
Query: 32 WINKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMH 91
W + + +L C + + C + + LQ D + + EM+ KM
Sbjct: 82 WFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQ----AFDDFIFAFFAVEMVVKMV 137
Query: 92 IRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMI 151
GI G Y+ D W D F+V + L + ++ S +R+ RPL I
Sbjct: 138 ALGIF-GKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-----FSAVRTVRVLRPLRAI 191
Query: 152 RAFRIYFRFELPRTRI-TNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF-GTFTYHCVV 209
+P RI +L + + +V + F ++GI+GVQ++ G C +
Sbjct: 192 N--------RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL 243
Query: 210 --NDTKPGNVTWNSLAIPDTH------CSPELEEG------------------------- 236
N + P +V + CS E G
Sbjct: 244 PENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYE 303
Query: 237 -YQCPPGFKCMDLEDL------GLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRA 289
Y C++ G G F+ IG + +++ + EGWV +MY
Sbjct: 304 AYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFV 363
Query: 290 IDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQM 335
+D+ + ++ YFI LI ++ + N+ + VI F+E + + Q+
Sbjct: 364 MDAH-SFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQL 408
Score = 50.8 bits (120), Expect = 1e-05
Identities = 40/161 (24%), Positives = 73/161 (45%), Gaps = 9/161 (5%)
Query: 887 YLDWVMIIVTICSCISMMFESPFRRV----MHAPTLQIAEYVFVIFMSIELNLKIMADGL 942
+ + + ++V + +C+++ P + LQ + F ++E+ +K++A G+
Sbjct: 82 WFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGI 141
Query: 943 FFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQ 1002
F + D +D FI + ++ QNV + + +R LRPLR VP
Sbjct: 142 F-GKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSA----VRTVRVLRPLRAINRVPS 196
Query: 1003 MRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKL 1043
MR +V L + V +L + +F GVQL+AG L
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLL 237
Score = 48.9 bits (115), Expect = 4e-05
Identities = 21/67 (31%), Positives = 40/67 (59%)
Query: 1097 NFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVGPIHGIYIHVFVFLGCMIGLTLFVGVVI 1156
NFDN+G A +A+F+V++L+GWV++ ++ + IY + + +G + L + V+
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
Query: 1157 ANFNENK 1163
F+E K
Sbjct: 396 TQFSETK 402
Score = 37.4 bits (85), Expect = 0.13
Identities = 21/62 (33%), Positives = 37/62 (59%), Gaps = 4/62 (6%)
Query: 537 FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVA 596
F A++++FQ++T EGWVD+M ++A H + IYFIL + + +++L +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDA--HSFYNF--IYFILLIIVGSFFMINLCLV 392
Query: 597 VI 598
VI
Sbjct: 393 VI 394
Score = 35.8 bits (81), Expect = 0.37
Identities = 29/128 (22%), Positives = 52/128 (40%), Gaps = 18/128 (14%)
Query: 1371 NFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSF 1430
NF + G A +F+++T E W IM Y+ D ++ +YF
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIM----------------YFVMDAHSFYN-FIYFILL 378
Query: 1431 YVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRV 1490
++ ++ M+NL + +I FS E QL+ +R + G +
Sbjct: 379 IIVGSFFMINLCLVVIATQFS-ETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELL 437
Query: 1491 KFLLRLLR 1498
K+L+ +LR
Sbjct: 438 KYLVYILR 445
Score = 33.9 bits (76), Expect = 1.4
Identities = 29/132 (21%), Positives = 59/132 (44%), Gaps = 19/132 (14%)
Query: 415 YDEFYLAEVAFTVLFDLEALLKIWCLGFTG---YISSSLHKFELLLVIGTTLHVYPDLYH 471
+D+F A F +E ++K+ LG G Y+ + ++ + +VI L DL +
Sbjct: 120 FDDFIFA------FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQN 173
Query: 472 SQFTYFQ---VLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF 528
F+ + VLR +R I P++ V + LG++++ + + + +Q++
Sbjct: 174 VSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Query: 529 -------CFVEE 533
CF+ E
Sbjct: 234 AGLLRNRCFLPE 245
>gi|193788544 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 19 [Homo sapiens]
Length = 2135
Score = 221 bits (562), Expect = 6e-57
Identities = 190/712 (26%), Positives = 338/712 (47%), Gaps = 62/712 (8%)
Query: 891 VMIIVTICSCISMMFESPFRRV-MHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
+++ + S IS+ E P + L + VF +IE+ LK+ A G F +
Sbjct: 902 LILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSF 961
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRE 1009
R++ ++D+ + VSLI + ++L VLR LRPLR ++ VV+
Sbjct: 962 CRNYFNILDLLVVSVSLISFGIQSSAINV---VKILRVLRVLRPLRAINRAKGLKHVVQC 1018
Query: 1010 LFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSK 1069
+F + I + I+ L +FA GVQLF GKL C+D + +C G +
Sbjct: 1019 VFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNY-------- 1070
Query: 1070 NLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEV--RDVIIHR 1127
+ + GE PR W N + F+FDNV AM+ALF V + +GW E+ R + H
Sbjct: 1071 ---ITYKDGEVDHPIIQPRSWENSK-FDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHT 1126
Query: 1128 --VGPIH------GIYIHVFVFLGCMIGLTLFVGVVIANFNE--NKGTALLTVDQRRWED 1177
GPI+ I+ +++ + + +FVG VI F E + +D+ + +
Sbjct: 1127 EDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQC 1186
Query: 1178 LKSRLKIAQPL--HLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVK-WDVE 1234
++ LK A+PL ++P + + K++ + +F+ + +L+L ++ L+++ +
Sbjct: 1187 VEYALK-ARPLRRYIP----KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQS 1241
Query: 1235 DPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFAL 1294
+ + ++++FT +F +E+ +K+IA P G++ N +D L+ ++ V+L
Sbjct: 1242 CLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETN 1301
Query: 1295 LNAYTYMMGA---------CVIVFRFF------SICGKHVTLKMLLLTVVVSMYKSFFII 1339
+T + + FR F + + ++ LL T + S ++
Sbjct: 1302 PAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVA 1361
Query: 1340 VGMFLLLLCYAFAGVVLFGTVKYGE--NINRHANFSSAGKAITVLFRIVTGEDWNKIMHD 1397
+ + +L YA G+ +FG + + INR+ NF + +A+ +LFR TGE W IM
Sbjct: 1362 LLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLA 1421
Query: 1398 CMVQ---PPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFY 1454
CM P P T T CG+ + A+ YF SFY++ A++++NL VA+I++NF Y
Sbjct: 1422 CMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFD--Y 1478
Query: 1455 STEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEV-DLDKDKLLFK 1513
T + +L + L F+ IW D + +G I V LLR ++ L L ++ K
Sbjct: 1479 LTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACK 1538
Query: 1514 HMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEE 1565
+ L++ G V F+ L L ++ I+ LE+ A E+L I++
Sbjct: 1539 RLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQ--ANEELRAIIKK 1588
Score = 145 bits (366), Expect = 3e-34
Identities = 149/689 (21%), Positives = 297/689 (43%), Gaps = 109/689 (15%)
Query: 74 LDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIV 133
++ L + ++T E K+ G++ ++Y+++ W + D +V V L + E A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVV---VGLFSAILEQATKA 218
Query: 134 DQMSPWGMLRIPRPLIMIRAFRIYFRFEL----PRTRIT-NILKRSGEQIWSVSIFLLFF 188
D + G + +RAFR+ L P ++ N + ++ + +++ +LF
Sbjct: 219 DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 278
Query: 189 LLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPD--THCSPELEEGYQCPPGFKCM 246
+++Y I+G+++F + N +A D + C+ E G QC G C
Sbjct: 279 IIIYAIIGLELFMGKMHKTCYNQ--------EGIAAEDDPSPCALETGHGRQCQNGTVCK 330
Query: 247 DLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLI 306
G + G + F+ ++ TV++ + EGW ++Y D+ R + YF+TLI
Sbjct: 331 P----GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLI 386
Query: 307 FFLAWLVKNVFIAVIIETF------AEIRVQFQQM---------------WGSRS----- 340
++ V N+ + V+ F A+ R FQ++ W +++
Sbjct: 387 IIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDP 446
Query: 341 ---------------STTSTATTQMFHEDAAGG-------WQLVAVDVNKPQGRA----- 373
S ++ T + E+ AGG +A ++K +
Sbjct: 447 ENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRW 506
Query: 374 -PACLQKM---MRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLF 429
C +K ++S+VF+ ++ +V ++ + AS +Y N+ + + A A LF
Sbjct: 507 NRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD--TANKALLALF 564
Query: 430 DLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLH-------VYPDLYHSQFTYFQVLRV 482
E LLK++ LG Y S ++F+ +V G L + L S ++LR+
Sbjct: 565 TAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRI 624
Query: 483 VRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR------ 536
++ + +L + V + + + SL++ +I+ S + +Q+F D
Sbjct: 625 FKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRS 684
Query: 537 -FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP--VVAIYFILYHLFATLILLSL 593
F FP++ +++FQILT E W VM + A G P +V IYFI+ + ILL++
Sbjct: 685 TFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNV 744
Query: 594 FVAVILDNLELDEDLKKLKQLKQSE---------ANADTKEKLPLRLRIFEKFPNRPQMV 644
F+A+ +DNL E L ++ ++ E A+ + K++L + + E ++ + +
Sbjct: 745 FLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE---SKEEKI 801
Query: 645 KISKLPSDFTVPKIRESFMKQFIDRQQQD 673
++ + +D P + M + +D
Sbjct: 802 ELKSITADGESPPATKINMDDLQPNENED 830
Score = 107 bits (267), Expect = 1e-22
Identities = 92/345 (26%), Positives = 161/345 (46%), Gaps = 41/345 (11%)
Query: 885 VTYLDW----VMIIVTI-CSCISMMFESPFRRVMHAPT---LQIAEYVFVIFMSIELNLK 936
++ ++W ++I++TI +C+++ PF T L+ EY+F+I ++E LK
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 937 IMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQL-----------L 985
++A GL F P A +R+ ++D I +V L F + Q A+ L L
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGL-FSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 986 MVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAK 1045
R LRPLR+ VP ++ V+ + + +++L+L +++++A G++LF GK+ K
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 1046 -CNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRN--FNFDNVG 1102
C + I ED + + KPG W P++ NFDN
Sbjct: 297 TCYNQEGIAAEDDPSPCALETGHGRQCQ---NGTVCKPG------WDGPKHGITNFDNFA 347
Query: 1103 NAMLALFEVLSLKGWVEVRDVIIHRVG-PIHGIYIHVFVFLGCMIGLTLFVGVVIANFNE 1161
AML +F+ ++++GW +V + VG IY + +G L L +GV+ F++
Sbjct: 348 FAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSK 407
Query: 1162 NKGTALLTVD-------QRRWEDLKSRLK-IAQPLHLPPRPDNDG 1198
+ A D Q+ EDLK L I Q + P +++G
Sbjct: 408 EREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEG 452
Score = 102 bits (255), Expect = 2e-21
Identities = 131/626 (20%), Positives = 259/626 (41%), Gaps = 97/626 (15%)
Query: 33 INKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHI 92
+N +L+ ++S IS+ P+ +H ++ F D + ++T E+ KM
Sbjct: 894 VNDTIFTNLILFFILLSSISLAAEDPV--QHTSFRNHILFYFDIVFTTIFTIEIALKMTA 951
Query: 93 RGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIR 152
G S+ ++ + + D L VS+ L F I Q S +++I R L ++R
Sbjct: 952 YGAFLHKGSFCRNYFNILD-----LLVVSVSLISFGI-----QSSAINVVKILRVLRVLR 1001
Query: 153 AFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDT 212
R R + + + + + I ++ I ++ +GVQ+F Y C + +
Sbjct: 1002 PLRAINRAKGLK-HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS-DSS 1059
Query: 213 KPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFT 272
K I T+ E++ P ++ + F+ + ++
Sbjct: 1060 KQTEAECKGNYI--TYKDGEVDHPIIQPRSWENSKFD-------------FDNVLAAMMA 1104
Query: 273 VYEAASQEGWVFLMYRAIDSFPRWRSYFY---------FITLIFFLAWLVKNVFIAVIIE 323
++ ++ EGW L+YR+IDS + Y FI I +A+ + N+F+ +I
Sbjct: 1105 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1164
Query: 324 TFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPACLQKMMRS 383
TF E Q +Q + + + + A + + P+ + + ++ S
Sbjct: 1165 TFQE---QGEQEYKNCELDKNQRQCVEYALKARPLRRYI------PKNQHQYKVWYVVNS 1215
Query: 384 SVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFT 443
+ F + ++ ++ I A +Y G++ + + + FT LF +E +LK+
Sbjct: 1216 TYFEYLMFVLILLNTICLAMQHY-GQSCLFKI-AMNILNMLFTGLFTVEMILKLIAFKPK 1273
Query: 444 GYISSSLHKFELLLVIGTTLHVY----PDLYHSQ--------------FTYFQVLRVVRL 485
GY S + F+ L+VIG+ + V H+Q T+F++ RV+RL
Sbjct: 1274 GYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRL 1333
Query: 486 IKI---SPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFV-----EELDR- 536
+K+ + ++ + L + + L + + I +Q+F + E++R
Sbjct: 1334 VKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRN 1393
Query: 537 --FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP-----------------VVAI 577
F TFP+A + +F+ T E W D+M + G AP
Sbjct: 1394 NNFQTFPQAVLLLFRCATGEAWQDIMLACM--PGKKCAPESEPSNSTEGETPCGSSFAVF 1451
Query: 578 YFILYHLFATLILLSLFVAVILDNLE 603
YFI +++ ++++LFVAVI+DN +
Sbjct: 1452 YFISFYMLCAFLIINLFVAVIMDNFD 1477
Score = 78.2 bits (191), Expect = 7e-14
Identities = 57/250 (22%), Positives = 122/250 (48%), Gaps = 17/250 (6%)
Query: 1206 ITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSP 1265
+ + F+ I L+ L + S ++ + +T T + +F E+ +K+ ++
Sbjct: 518 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 577
Query: 1266 AGFWQSRRNRYDLLVTSLGVVWVVL-HFALLNAYTYMMGACVIVFRFFSICGKHVTLKML 1324
++ S NR+D V G++ +L +++ + CV + R F I +L L
Sbjct: 578 QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNL 637
Query: 1325 LLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFG-TVKYGENINRHANFSSAGKAITVLF 1383
+ +++ S+ +++ +FL ++ ++ G+ LFG + E R + F + +++ +F
Sbjct: 638 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVF 697
Query: 1384 RIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGAL--MYFCSFYVIIAYIMLNL 1441
+I+TGEDWN +M+D ++ A ++ G L +YF ++ YI+LN+
Sbjct: 698 QILTGEDWNSVMYDGIM-------------AYGGPSFPGMLVCIYFIILFICGNYILLNV 744
Query: 1442 LVAIIVENFS 1451
+AI V+N +
Sbjct: 745 FLAIAVDNLA 754
Score = 58.9 bits (141), Expect = 4e-08
Identities = 68/287 (23%), Positives = 120/287 (41%), Gaps = 68/287 (23%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDTL---LMFLYTAEMIAKMHIRGIVKGDSSYVKD 105
+ V +NT + EHY ++T DT L+ L+TAEM+ KM+ G+ +Y
Sbjct: 528 IFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL----QAYFVS 583
Query: 106 RWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRT 165
+ FD F+V + +L +I MSP G + + R + ++R F+I R+ +
Sbjct: 584 LFNRFDCFVVCGGILETILVETKI------MSPLG-ISVLRCVRLLRIFKIT-RYWNSLS 635
Query: 166 RITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIP 225
+ L S I S+ + L F++++ +LG+Q+FG G ++ +
Sbjct: 636 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFG-------------GKFNFDEM--- 679
Query: 226 DTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFL 285
+ S F+ S+ TV++ + E W +
Sbjct: 680 -------------------------------QTRRSTFDNFPQSLLTVFQILTGEDWNSV 708
Query: 286 MYRAI-----DSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAE 327
MY I SFP YFI L +++ NVF+A+ ++ A+
Sbjct: 709 MYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLAD 755
Score = 51.2 bits (121), Expect = 9e-06
Identities = 64/306 (20%), Positives = 120/306 (39%), Gaps = 62/306 (20%)
Query: 890 WVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
W++I + + +++ E + A + + E+ LK+ + GL ++
Sbjct: 525 WLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSL 584
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVP---QMRKV 1006
F D F+ ++ + + + G + VLRC+R LRIFK+ + +
Sbjct: 585 FNRF----DCFVVCGGILETILVETKIMSPLG---ISVLRCVRLLRIFKITRYWNSLSNL 637
Query: 1007 VRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVS 1066
V L + + I + +LL +++F+ G+QLF GK F +
Sbjct: 638 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGK------------------FNFDE- 678
Query: 1067 VSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVR-DVII 1125
R FDN ++L +F++L+ + W V D I+
Sbjct: 679 ------------------------MQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIM 714
Query: 1126 HRVGP-----IHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKS 1180
GP + IY + G I L +F+ + + N + + LT Q+ E+ K
Sbjct: 715 AYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAES---LTSAQKEEEEEKE 771
Query: 1181 RLKIAQ 1186
R K+A+
Sbjct: 772 RKKLAR 777
Score = 42.7 bits (99), Expect = 0.003
Identities = 57/297 (19%), Positives = 110/297 (37%), Gaps = 73/297 (24%)
Query: 1212 FKRTIALLVLAQSVLLSV----KWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMS--- 1264
F+ I L + A V L++ D + L + +F IF +E +K+IA
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLF 185
Query: 1265 -PAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGA-----------CVIVFRFF 1312
P + ++ N D ++ +G+ +L A +G V R
Sbjct: 186 HPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPL 245
Query: 1313 SICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLF--------------- 1357
+ +L+++L +++ +M I + + +++ YA G+ LF
Sbjct: 246 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIA 305
Query: 1358 --------------------GTV-KYGENINRHA--NFSSAGKAITVLFRIVTGEDWNKI 1394
GTV K G + +H NF + A+ +F+ +T E W +
Sbjct: 306 AEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDV 365
Query: 1395 MHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFS 1451
+ YW D +YF + +I ++ +LNL++ ++ FS
Sbjct: 366 L----------------YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS 406
>gi|193788540 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 16 [Homo sapiens]
Length = 2138
Score = 221 bits (562), Expect = 6e-57
Identities = 190/712 (26%), Positives = 338/712 (47%), Gaps = 62/712 (8%)
Query: 891 VMIIVTICSCISMMFESPFRRV-MHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
+++ + S IS+ E P + L + VF +IE+ LK+ A G F +
Sbjct: 905 LILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSF 964
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRE 1009
R++ ++D+ + VSLI + ++L VLR LRPLR ++ VV+
Sbjct: 965 CRNYFNILDLLVVSVSLISFGIQSSAINV---VKILRVLRVLRPLRAINRAKGLKHVVQC 1021
Query: 1010 LFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSK 1069
+F + I + I+ L +FA GVQLF GKL C+D + +C G +
Sbjct: 1022 VFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNY-------- 1073
Query: 1070 NLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEV--RDVIIHR 1127
+ + GE PR W N + F+FDNV AM+ALF V + +GW E+ R + H
Sbjct: 1074 ---ITYKDGEVDHPIIQPRSWENSK-FDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHT 1129
Query: 1128 --VGPIH------GIYIHVFVFLGCMIGLTLFVGVVIANFNE--NKGTALLTVDQRRWED 1177
GPI+ I+ +++ + + +FVG VI F E + +D+ + +
Sbjct: 1130 EDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQC 1189
Query: 1178 LKSRLKIAQPL--HLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVK-WDVE 1234
++ LK A+PL ++P + + K++ + +F+ + +L+L ++ L+++ +
Sbjct: 1190 VEYALK-ARPLRRYIP----KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQS 1244
Query: 1235 DPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFAL 1294
+ + ++++FT +F +E+ +K+IA P G++ N +D L+ ++ V+L
Sbjct: 1245 CLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETN 1304
Query: 1295 LNAYTYMMGA---------CVIVFRFF------SICGKHVTLKMLLLTVVVSMYKSFFII 1339
+T + + FR F + + ++ LL T + S ++
Sbjct: 1305 PAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVA 1364
Query: 1340 VGMFLLLLCYAFAGVVLFGTVKYGE--NINRHANFSSAGKAITVLFRIVTGEDWNKIMHD 1397
+ + +L YA G+ +FG + + INR+ NF + +A+ +LFR TGE W IM
Sbjct: 1365 LLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLA 1424
Query: 1398 CMVQ---PPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFY 1454
CM P P T T CG+ + A+ YF SFY++ A++++NL VA+I++NF Y
Sbjct: 1425 CMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFD--Y 1481
Query: 1455 STEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEV-DLDKDKLLFK 1513
T + +L + L F+ IW D + +G I V LLR ++ L L ++ K
Sbjct: 1482 LTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACK 1541
Query: 1514 HMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEE 1565
+ L++ G V F+ L L ++ I+ LE+ A E+L I++
Sbjct: 1542 RLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQ--ANEELRAIIKK 1591
Score = 147 bits (370), Expect = 1e-34
Identities = 149/687 (21%), Positives = 296/687 (43%), Gaps = 102/687 (14%)
Query: 74 LDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIV 133
++ L + ++T E K+ G++ ++Y+++ W + D +V V L + E A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVV---VGLFSAILEQATKA 218
Query: 134 DQMSPWGMLRIPRPLIMIRAFRIYFRFEL----PRTRIT-NILKRSGEQIWSVSIFLLFF 188
D + G + +RAFR+ L P ++ N + ++ + +++ +LF
Sbjct: 219 DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 278
Query: 189 LLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDL 248
+++Y I+G+++F + N +V P C+ E G QC G C
Sbjct: 279 IIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSP---CALETGHGRQCQNGTVCKP- 334
Query: 249 EDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFF 308
G + G + F+ ++ TV++ + EGW ++Y D+ R + YF+TLI
Sbjct: 335 ---GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIII 391
Query: 309 LAWLVKNVFIAVIIETF------AEIRVQFQQM---------------WGSRS------- 340
++ V N+ + V+ F A+ R FQ++ W +++
Sbjct: 392 GSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPEN 451
Query: 341 -------------STTSTATTQMFHEDAAGG-------WQLVAVDVNKPQGRA------P 374
S ++ T + E+ AGG +A ++K +
Sbjct: 452 EDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNR 511
Query: 375 ACLQKM---MRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDL 431
C +K ++S+VF+ ++ +V ++ + AS +Y N+ + + A A LF
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD--TANKALLALFTA 569
Query: 432 EALLKIWCLGFTGYISSSLHKFELLLVIGTTLH-------VYPDLYHSQFTYFQVLRVVR 484
E LLK++ LG Y S ++F+ +V G L + L S ++LR+ +
Sbjct: 570 EMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFK 629
Query: 485 LIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR-------F 537
+ + +L + V + + + SL++ +I+ S + +Q+F D F
Sbjct: 630 ITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTF 689
Query: 538 TTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP--VVAIYFILYHLFATLILLSLFV 595
FP++ +++FQILT E W VM + A G P +V IYFI+ + ILL++F+
Sbjct: 690 DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFL 749
Query: 596 AVILDNLELDEDLKKLKQLKQSE---------ANADTKEKLPLRLRIFEKFPNRPQMVKI 646
A+ +DNL E L ++ ++ E A+ + K++L + + E ++ + +++
Sbjct: 750 AIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE---SKEEKIEL 806
Query: 647 SKLPSDFTVPKIRESFMKQFIDRQQQD 673
+ +D P + M + +D
Sbjct: 807 KSITADGESPPATKINMDDLQPNENED 833
Score = 104 bits (260), Expect = 7e-22
Identities = 94/357 (26%), Positives = 164/357 (45%), Gaps = 62/357 (17%)
Query: 885 VTYLDW----VMIIVTI-CSCISMMFESPFRRVMHAPT---LQIAEYVFVIFMSIELNLK 936
++ ++W ++I++TI +C+++ PF T L+ EY+F+I ++E LK
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 937 IMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQL-----------L 985
++A GL F P A +R+ ++D I +V L F + Q A+ L L
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGL-FSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 986 MVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAK 1045
R LRPLR+ VP ++ V+ + + +++L+L +++++A G++LF GK+ K
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 1046 C-------------NDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWAN 1092
+DP+ E +G N +V K PG W
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCK-------PG-----------WDG 338
Query: 1093 PRN--FNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVG-PIHGIYIHVFVFLGCMIGLT 1149
P++ NFDN AML +F+ ++++GW +V + VG IY + +G L
Sbjct: 339 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLN 398
Query: 1150 LFVGVVIANFNENKGTALLTVD-------QRRWEDLKSRLK-IAQPLHLPPRPDNDG 1198
L +GV+ F++ + A D Q+ EDLK L I Q + P +++G
Sbjct: 399 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEG 455
Score = 102 bits (255), Expect = 2e-21
Identities = 131/626 (20%), Positives = 259/626 (41%), Gaps = 97/626 (15%)
Query: 33 INKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHI 92
+N +L+ ++S IS+ P+ +H ++ F D + ++T E+ KM
Sbjct: 897 VNDTIFTNLILFFILLSSISLAAEDPV--QHTSFRNHILFYFDIVFTTIFTIEIALKMTA 954
Query: 93 RGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIR 152
G S+ ++ + + D L VS+ L F I Q S +++I R L ++R
Sbjct: 955 YGAFLHKGSFCRNYFNILD-----LLVVSVSLISFGI-----QSSAINVVKILRVLRVLR 1004
Query: 153 AFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDT 212
R R + + + + + I ++ I ++ +GVQ+F Y C + +
Sbjct: 1005 PLRAINRAKGLK-HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS-DSS 1062
Query: 213 KPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFT 272
K I T+ E++ P ++ + F+ + ++
Sbjct: 1063 KQTEAECKGNYI--TYKDGEVDHPIIQPRSWENSKFD-------------FDNVLAAMMA 1107
Query: 273 VYEAASQEGWVFLMYRAIDSFPRWRSYFY---------FITLIFFLAWLVKNVFIAVIIE 323
++ ++ EGW L+YR+IDS + Y FI I +A+ + N+F+ +I
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 324 TFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPACLQKMMRS 383
TF E Q +Q + + + + A + + P+ + + ++ S
Sbjct: 1168 TFQE---QGEQEYKNCELDKNQRQCVEYALKARPLRRYI------PKNQHQYKVWYVVNS 1218
Query: 384 SVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFT 443
+ F + ++ ++ I A +Y G++ + + + FT LF +E +LK+
Sbjct: 1219 TYFEYLMFVLILLNTICLAMQHY-GQSCLFKI-AMNILNMLFTGLFTVEMILKLIAFKPK 1276
Query: 444 GYISSSLHKFELLLVIGTTLHVY----PDLYHSQ--------------FTYFQVLRVVRL 485
GY S + F+ L+VIG+ + V H+Q T+F++ RV+RL
Sbjct: 1277 GYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRL 1336
Query: 486 IKI---SPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFV-----EELDR- 536
+K+ + ++ + L + + L + + I +Q+F + E++R
Sbjct: 1337 VKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRN 1396
Query: 537 --FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP-----------------VVAI 577
F TFP+A + +F+ T E W D+M + G AP
Sbjct: 1397 NNFQTFPQAVLLLFRCATGEAWQDIMLACM--PGKKCAPESEPSNSTEGETPCGSSFAVF 1454
Query: 578 YFILYHLFATLILLSLFVAVILDNLE 603
YFI +++ ++++LFVAVI+DN +
Sbjct: 1455 YFISFYMLCAFLIINLFVAVIMDNFD 1480
Score = 78.2 bits (191), Expect = 7e-14
Identities = 57/250 (22%), Positives = 122/250 (48%), Gaps = 17/250 (6%)
Query: 1206 ITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSP 1265
+ + F+ I L+ L + S ++ + +T T + +F E+ +K+ ++
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1266 AGFWQSRRNRYDLLVTSLGVVWVVL-HFALLNAYTYMMGACVIVFRFFSICGKHVTLKML 1324
++ S NR+D V G++ +L +++ + CV + R F I +L L
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1325 LLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFG-TVKYGENINRHANFSSAGKAITVLF 1383
+ +++ S+ +++ +FL ++ ++ G+ LFG + E R + F + +++ +F
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVF 700
Query: 1384 RIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGAL--MYFCSFYVIIAYIMLNL 1441
+I+TGEDWN +M+D ++ A ++ G L +YF ++ YI+LN+
Sbjct: 701 QILTGEDWNSVMYDGIM-------------AYGGPSFPGMLVCIYFIILFICGNYILLNV 747
Query: 1442 LVAIIVENFS 1451
+AI V+N +
Sbjct: 748 FLAIAVDNLA 757
Score = 58.9 bits (141), Expect = 4e-08
Identities = 68/287 (23%), Positives = 120/287 (41%), Gaps = 68/287 (23%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDTL---LMFLYTAEMIAKMHIRGIVKGDSSYVKD 105
+ V +NT + EHY ++T DT L+ L+TAEM+ KM+ G+ +Y
Sbjct: 531 IFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL----QAYFVS 586
Query: 106 RWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRT 165
+ FD F+V + +L +I MSP G + + R + ++R F+I R+ +
Sbjct: 587 LFNRFDCFVVCGGILETILVETKI------MSPLG-ISVLRCVRLLRIFKIT-RYWNSLS 638
Query: 166 RITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIP 225
+ L S I S+ + L F++++ +LG+Q+FG G ++ +
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFG-------------GKFNFDEM--- 682
Query: 226 DTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFL 285
+ S F+ S+ TV++ + E W +
Sbjct: 683 -------------------------------QTRRSTFDNFPQSLLTVFQILTGEDWNSV 711
Query: 286 MYRAI-----DSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAE 327
MY I SFP YFI L +++ NVF+A+ ++ A+
Sbjct: 712 MYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLAD 758
Score = 51.2 bits (121), Expect = 9e-06
Identities = 64/306 (20%), Positives = 120/306 (39%), Gaps = 62/306 (20%)
Query: 890 WVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
W++I + + +++ E + A + + E+ LK+ + GL ++
Sbjct: 528 WLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSL 587
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVP---QMRKV 1006
F D F+ ++ + + + G + VLRC+R LRIFK+ + +
Sbjct: 588 FNRF----DCFVVCGGILETILVETKIMSPLG---ISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1007 VRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVS 1066
V L + + I + +LL +++F+ G+QLF GK F +
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGK------------------FNFDE- 681
Query: 1067 VSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVR-DVII 1125
R FDN ++L +F++L+ + W V D I+
Sbjct: 682 ------------------------MQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIM 717
Query: 1126 HRVGP-----IHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKS 1180
GP + IY + G I L +F+ + + N + + LT Q+ E+ K
Sbjct: 718 AYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAES---LTSAQKEEEEEKE 774
Query: 1181 RLKIAQ 1186
R K+A+
Sbjct: 775 RKKLAR 780
Score = 41.6 bits (96), Expect = 0.007
Identities = 57/300 (19%), Positives = 110/300 (36%), Gaps = 76/300 (25%)
Query: 1212 FKRTIALLVLAQSVLLSV----KWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMS--- 1264
F+ I L + A V L++ D + L + +F IF +E +K+IA
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLF 185
Query: 1265 -PAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGA-----------CVIVFRFF 1312
P + ++ N D ++ +G+ +L A +G V R
Sbjct: 186 HPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPL 245
Query: 1313 SICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLF--------------- 1357
+ +L+++L +++ +M I + + +++ YA G+ LF
Sbjct: 246 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIA 305
Query: 1358 -----------------------GTV-KYGENINRHA--NFSSAGKAITVLFRIVTGEDW 1391
GTV K G + +H NF + A+ +F+ +T E W
Sbjct: 306 DVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGW 365
Query: 1392 NKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFS 1451
++ YW D +YF + +I ++ +LNL++ ++ FS
Sbjct: 366 TDVL----------------YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS 409
>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
isoform 5 [Homo sapiens]
Length = 2321
Score = 221 bits (562), Expect = 6e-57
Identities = 265/1159 (22%), Positives = 483/1159 (41%), Gaps = 140/1159 (12%)
Query: 378 QKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKI 437
+K++ S F I+ + V+ + Y+ E + ++ + FT LF LE LLK+
Sbjct: 737 RKIVDSKYFGRGIMIAILVNTLSMGIEYH--EQPEELTNALEISNIVFTSLFALEMLLKL 794
Query: 438 WCLGFTGYISSSLHKFELLLVIGTTLHVYPDLYH--SQFTYFQVLRVVRLIKISPALEDF 495
G GYI + + F+ ++V+ + + S F+++RV++L++ PAL+
Sbjct: 795 LVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQ 854
Query: 496 VYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF-C-FVEELD--------RFTTFPRAFM 545
+ + + + + + + S + + +F C F E D F + A +
Sbjct: 855 LVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIV 914
Query: 546 SMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVAVILDNLELD 605
++FQILTQE W V+ + + WA A+YFI F +L +L VA++++ + +
Sbjct: 915 TVFQILTQEDWNKVLYNGMASTSS-WA---ALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
Query: 606 EDLKKLK--------QLKQSEANADTKEKLPLRLRIFEKFPNRPQMVKISKLPSDFTVPK 657
E K+ QL D + K L S P+
Sbjct: 971 EISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPE 1030
Query: 658 IRESFMKQFIDRQQQDTCCLLRSLPT-------------TSSSSCD----HSKRS--AIE 698
+R+S + I L +S T +SS S + H +S +
Sbjct: 1031 LRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR 1090
Query: 699 DNKYIDQKLRKSVFSIRA-RNLLEKETAVTKILRACTRQRMLSGSFEGQPAKERSILSVQ 757
+ + S S R+ RN L + ++ + + R+ +LSG EGQ +++ S +
Sbjct: 1091 SSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSG--EGQESQDEEESSEE 1148
Query: 758 HHIRQERRSLRHGSNSQRISRGKSLETLTQDHSNTVRYRNAQREDSEIKMIQEKKEQAEM 817
RH + +R ++ T R + + SE + K +
Sbjct: 1149 ERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRL 1208
Query: 818 KRKVQEEELRENHPYFDKPLFIVGREHRFRNFCRVVVRARFNASKTDPVTGAVKNTKYHQ 877
R ++ ++ + D + E R +RAR A + + +
Sbjct: 1209 ARALRPDDPPLDGDDADDEGNLSKGER-----VRAWIRARLPACCLERDSWSAYIFPPQS 1263
Query: 878 LYDLL--GLVTY--LDWVMIIVTICSCISMMFESPFRRVMHAPT--LQIAEYVFVIFMSI 931
+ LL ++T+ D V++++ +CI++ E P A L ++ Y+F
Sbjct: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323
Query: 932 ELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLL------ 985
E+ +K++A G F A +R V+D + L+S+I + ++ ++SG ++L
Sbjct: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDIL---VSMVSDSGTKILGMLRVL 1380
Query: 986 MVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAK 1045
+LR LRPLR+ ++ VV L S K I + ++ ++F GVQLF GK
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Query: 1046 CNDP---NIIRREDC-NGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNV 1101
C NI + DC +R WV +NFDN+
Sbjct: 1441 CQGEDTRNITNKSDCAEASYR----------------------WVRH------KYNFDNL 1472
Query: 1102 GNAMLALFEVLSLKGWVEVRDVIIHRVG----------PIHGIYIHVFVFLGCMIGLTLF 1151
G A+++LF + S GWV++ + VG P +Y F+ + L +F
Sbjct: 1473 GQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMF 1532
Query: 1152 VGVVIANFNENKGTALLTVDQRRWEDLKSRLK---------IAQPLHLPPRPDNDGFRAK 1202
VGVV+ NF++ + +RR E RL+ +A+ P D FR
Sbjct: 1533 VGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLL 1592
Query: 1203 MYDITQHPFFKRTIALLVLAQSVLLSVK-WDVEDPVTVPLATMSVVFTFIFVLEVTMKII 1261
++ + + I ++ V ++++ + + L + +FT IFVLE K++
Sbjct: 1593 VHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLV 1652
Query: 1262 AMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACVIVFRFFSICGKHVTL 1321
A F+Q R N+ DL + L ++ + L +NA + + + R I L
Sbjct: 1653 AFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLL 1712
Query: 1322 KM------LLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGEN-----INRHA 1370
KM LL TV+ ++ + + + LL +A GV LFG ++ E + RHA
Sbjct: 1713 KMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHA 1772
Query: 1371 NFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSF 1430
F + G A LFR+ TG++WN IM D + C + + C N + +YF SF
Sbjct: 1773 TFRNFGMAFLTLFRVSTGDNWNGIMKDTLRD---CDQE------STCYNTVISPIYFVSF 1823
Query: 1431 YVIIAYIMLNLLVAIIVEN 1449
+ ++++N+++A+++++
Sbjct: 1824 VLTAQFVLVNVVIAVLMKH 1842
Score = 134 bits (337), Expect = 8e-31
Identities = 136/650 (20%), Positives = 287/650 (44%), Gaps = 92/650 (14%)
Query: 34 NKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIR 93
+K + H +L + ++ I++ M P H ++T + + + ++ AEM K+
Sbjct: 1275 HKMFDHVVL-VIIFLNCITIAMERPKIDPHSAERIFLTLS-NYIFTAVFLAEMTVKVVAL 1332
Query: 94 GIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRA 153
G G+ +Y++ W V DG +V + +++ + ++D ++ GMLR+ R L +R
Sbjct: 1333 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM--VSDSGTKIL--GMLRVLRLLRTLRP 1388
Query: 154 FRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTK 213
R+ R + + + L S + I ++ + F +++GILGVQ+F + C DT+
Sbjct: 1389 LRVISRAQGLKL-VVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTR 1447
Query: 214 PGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTV 273
N+T S C+ E Y R F+ +G ++ ++
Sbjct: 1448 --NITNKS------DCA---EASY-----------------RWVRHKYNFDNLGQALMSL 1479
Query: 274 YEAASQEGWVFLMYRAID----------SFPRWRSYFYFITLIFFLAWLVKNVFIAVIIE 323
+ AS++GWV +MY +D + W YFI+ + +A+ V N+F+ V++E
Sbjct: 1480 FVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW-MLLYFISFLLIVAFFVLNMFVGVVVE 1538
Query: 324 TFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKP----QGRAPACLQK 379
F + R Q + + + + +A KP R +
Sbjct: 1539 NFHKCR---QHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHH 1595
Query: 380 MMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWC 439
+ S +FI ++ ++V+ A +Y+ + + FTV+F LE++ K+
Sbjct: 1596 LCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILD--EALKICNYIFTVIFVLESVFKLVA 1653
Query: 440 LGFTGYISSSLHKFELLLV-------------IGTTLHVYPDLYHSQFTYFQVLRVVRLI 486
GF + ++ +L +V + +L + P + ++ RV++L+
Sbjct: 1654 FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRI-MRVLRIARVLKLL 1712
Query: 487 KISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFV--------EELDR-- 536
K++ + + + ++G+L + L + +A+ +++F + E L R
Sbjct: 1713 KMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHA 1772
Query: 537 -FTTFPRAFMSMFQILTQEGWVDVMDQTL---NAVGHMWAPVVA-IYFILYHLFATLILL 591
F F AF+++F++ T + W +M TL + + V++ IYF+ + L A +L+
Sbjct: 1773 TFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLV 1832
Query: 592 SLFVAVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRP 641
++ +AV++ +LE + K+++ A+ + +L L ++ P+ P
Sbjct: 1833 NVVIAVLMKHLE--------ESNKEAKEEAELEAELELEMKTLSPQPHSP 1874
Score = 81.3 bits (199), Expect = 8e-15
Identities = 59/249 (23%), Positives = 118/249 (47%), Gaps = 24/249 (9%)
Query: 1206 ITQHPFFKRTIALLVLAQSVLLSVKWDVE-DPVTVPLATMSVVFTFIFVLEVTMKIIAMS 1264
I +F R I + +L ++ + +++ + + +T L ++VFT +F LE+ +K++
Sbjct: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
Query: 1265 PAGFWQSRRNRYDLLVTSLGVVWVVLHF---ALLNAYTYMMGACVIVFRFFSICGKHVTL 1321
P G+ ++ N +D ++ + V W ++ L T+ + + + RF + + +
Sbjct: 799 PFGYIKNPYNIFDGVIVVISV-WEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVV 857
Query: 1322 KMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAITV 1381
M + V + + + +F +L + F F + + G+ + NF S AI
Sbjct: 858 LMKTMDNVATFCMLLMLFIFIFSILGMHLFG--CKFASERDGDTLPDRKNFDSLLWAIVT 915
Query: 1382 LFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNL 1441
+F+I+T EDWNK++++ M + WA +YF + Y++ NL
Sbjct: 916 VFQILTQEDWNKVLYNGMAST--------SSWAA---------LYFIALMTFGNYVLFNL 958
Query: 1442 LVAIIVENF 1450
LVAI+VE F
Sbjct: 959 LVAILVEGF 967
Score = 80.9 bits (198), Expect = 1e-14
Identities = 73/314 (23%), Positives = 133/314 (42%), Gaps = 55/314 (17%)
Query: 369 PQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVL 428
PQ R +++ +F +L ++ ++ I A K + + L+ FT +
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
Query: 429 FDLEALLKI----WCLGFTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFT--------- 475
F E +K+ WC G Y+ SS + + LLV+ + + + + T
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
Query: 476 -YFQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF------ 528
+ LR +R+I + L+ V + K +G++VV + I+ + +Q+F
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
Query: 529 --------------C------FVEELDRFTTFPRAFMSMFQILTQEGWVDVMDQTLNAVG 568
C +V F +A MS+F + +++GWVD+M L+AVG
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500
Query: 569 HMWAPV------VAIYFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSEANAD 622
P+ + +YFI + L +L++FV V+++N K +Q ++ E
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFH------KCRQHQEEEEARR 1554
Query: 623 TKEKLPLRLRIFEK 636
+EK RLR EK
Sbjct: 1555 REEK---RLRRLEK 1565
Score = 68.2 bits (165), Expect = 7e-11
Identities = 66/304 (21%), Positives = 134/304 (44%), Gaps = 50/304 (16%)
Query: 1194 PDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVP---LATMSVVFTF 1250
P FR + I H F + +++ + ++++ DP + L + +FT
Sbjct: 1260 PPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTA 1319
Query: 1251 IFVLEVTMKIIAMS----PAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACV 1306
+F+ E+T+K++A+ + +S N D L+ + V+ +++ + ++ T ++G
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM-VSDSGTKILGMLR 1378
Query: 1307 IV-----FRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGT-- 1359
++ R + + LK+++ T++ S+ I+V + + GV LF
Sbjct: 1379 VLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1438
Query: 1360 -VKYGENIN----------------RHA-NFSSAGKAITVLFRIVTGEDWNKIMHDCMV- 1400
V GE+ RH NF + G+A+ LF + + + W IM+D +
Sbjct: 1439 FVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDA 1498
Query: 1401 ----QPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYST 1456
Q P + + L+YF SF +I+A+ +LN+ V ++VENF
Sbjct: 1499 VGVDQQPIMNHNPWM------------LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH 1546
Query: 1457 EEDQ 1460
+E++
Sbjct: 1547 QEEE 1550
Score = 62.0 bits (149), Expect = 5e-09
Identities = 59/277 (21%), Positives = 123/277 (44%), Gaps = 60/277 (21%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWC 108
+I++ +NT M E++ + +T L+ + ++T+ +M ++ +V G Y+K+ +
Sbjct: 750 MIAILVNTLSMGIEYHEQPEELTNALE-ISNIVFTSLFALEMLLKLLVYGPFGYIKNPYN 808
Query: 109 VFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRIT 168
+FDG +V V + +IV Q G L + R ++R ++ RF R
Sbjct: 809 IFDGVIV----------VISVWEIVGQQG--GGLSVLRTFRLMRVLKLV-RFLPALQRQL 855
Query: 169 NILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTH 228
+L ++ + + + + L+ F+ ++ ILG+ +FG C + G+ +PD
Sbjct: 856 VVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-----CKFASERDGD------TLPDR- 903
Query: 229 CSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYR 288
F+ + +I TV++ +QE W ++Y
Sbjct: 904 --------------------------------KNFDSLLWAIVTVFQILTQEDWNKVLYN 931
Query: 289 AIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETF 325
+ S W + YFI L+ F +++ N+ +A+++E F
Sbjct: 932 GMASTSSWAA-LYFIALMTFGNYVLFNLLVAILVEGF 967
Score = 53.1 bits (126), Expect = 2e-06
Identities = 72/346 (20%), Positives = 128/346 (36%), Gaps = 61/346 (17%)
Query: 32 WINKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMH 91
W + + +L C + + C + + LQ D + + EM+ KM
Sbjct: 82 WFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQ----AFDDFIFAFFAVEMVVKMV 137
Query: 92 IRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMI 151
GI G Y+ D W D F+V + L + ++ S +R+ RPL I
Sbjct: 138 ALGIF-GKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-----FSAVRTVRVLRPLRAI 191
Query: 152 RAFRIYFRFELPRTRI-TNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF-GTFTYHCVV 209
+P RI +L + + +V + F ++GI+GVQ++ G C +
Sbjct: 192 N--------RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL 243
Query: 210 --NDTKPGNVTWNSLAIPDTH------CSPELEEG------------------------- 236
N + P +V + CS E G
Sbjct: 244 PENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYE 303
Query: 237 -YQCPPGFKCMDLEDL------GLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRA 289
Y C++ G G F+ IG + +++ + EGWV +MY
Sbjct: 304 AYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFV 363
Query: 290 IDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQM 335
+D+ + ++ YFI LI ++ + N+ + VI F+E + + Q+
Sbjct: 364 MDAH-SFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQL 408
Score = 50.8 bits (120), Expect = 1e-05
Identities = 40/161 (24%), Positives = 73/161 (45%), Gaps = 9/161 (5%)
Query: 887 YLDWVMIIVTICSCISMMFESPFRRV----MHAPTLQIAEYVFVIFMSIELNLKIMADGL 942
+ + + ++V + +C+++ P + LQ + F ++E+ +K++A G+
Sbjct: 82 WFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGI 141
Query: 943 FFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQ 1002
F + D +D FI + ++ QNV + + +R LRPLR VP
Sbjct: 142 F-GKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSA----VRTVRVLRPLRAINRVPS 196
Query: 1003 MRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKL 1043
MR +V L + V +L + +F GVQL+AG L
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLL 237
Score = 48.9 bits (115), Expect = 4e-05
Identities = 21/67 (31%), Positives = 40/67 (59%)
Query: 1097 NFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVGPIHGIYIHVFVFLGCMIGLTLFVGVVI 1156
NFDN+G A +A+F+V++L+GWV++ ++ + IY + + +G + L + V+
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
Query: 1157 ANFNENK 1163
F+E K
Sbjct: 396 TQFSETK 402
Score = 37.4 bits (85), Expect = 0.13
Identities = 21/62 (33%), Positives = 37/62 (59%), Gaps = 4/62 (6%)
Query: 537 FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVA 596
F A++++FQ++T EGWVD+M ++A H + IYFIL + + +++L +
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDA--HSFYNF--IYFILLIIVGSFFMINLCLV 392
Query: 597 VI 598
VI
Sbjct: 393 VI 394
Score = 35.8 bits (81), Expect = 0.37
Identities = 29/128 (22%), Positives = 52/128 (40%), Gaps = 18/128 (14%)
Query: 1371 NFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSF 1430
NF + G A +F+++T E W IM Y+ D ++ +YF
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIM----------------YFVMDAHSFYN-FIYFILL 378
Query: 1431 YVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRV 1490
++ ++ M+NL + +I FS E QL+ +R + G +
Sbjct: 379 IIVGSFFMINLCLVVIATQFS-ETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELL 437
Query: 1491 KFLLRLLR 1498
K+L+ +LR
Sbjct: 438 KYLVYILR 445
Score = 33.9 bits (76), Expect = 1.4
Identities = 29/132 (21%), Positives = 59/132 (44%), Gaps = 19/132 (14%)
Query: 415 YDEFYLAEVAFTVLFDLEALLKIWCLGFTG---YISSSLHKFELLLVIGTTLHVYPDLYH 471
+D+F A F +E ++K+ LG G Y+ + ++ + +VI L DL +
Sbjct: 120 FDDFIFA------FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQN 173
Query: 472 SQFTYFQ---VLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF 528
F+ + VLR +R I P++ V + LG++++ + + + +Q++
Sbjct: 174 VSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Query: 529 -------CFVEE 533
CF+ E
Sbjct: 234 AGLLRNRCFLPE 245
>gi|193788534 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 12 [Homo sapiens]
Length = 2146
Score = 219 bits (559), Expect = 1e-56
Identities = 193/728 (26%), Positives = 341/728 (46%), Gaps = 57/728 (7%)
Query: 891 VMIIVTICSCISMMFESPFRRV-MHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
+++ + S IS+ E P + L A+YVF ++E+ LK+ A G F +
Sbjct: 905 LILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSF 964
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRE 1009
R++ ++D+ + VSLI + ++L VLR LRPLR ++ VV+
Sbjct: 965 CRNYFNILDLLVVSVSLISFGIQSSAINV---VKILRVLRVLRPLRAINRAKGLKHVVQC 1021
Query: 1010 LFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSK 1069
+F + I + I+ L +FA GVQLF GKL C+D + +C G +
Sbjct: 1022 VFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNY-------- 1073
Query: 1070 NLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEV--RDVIIHR 1127
+ + GE PR W N + F+FDNV AM+ALF V + +GW E+ R + H
Sbjct: 1074 ---ITYKDGEVDHPIIQPRSWENSK-FDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHT 1129
Query: 1128 --VGPIH------GIYIHVFVFLGCMIGLTLFVGVVIANFNE--NKGTALLTVDQRRWED 1177
GPI+ I+ +++ + + +FVG VI F E + +D+ + +
Sbjct: 1130 EDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQC 1189
Query: 1178 LKSRLKIAQPL--HLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVK-WDVE 1234
++ LK A+PL ++P + + K++ + +F+ + +L+L ++ L+++ +
Sbjct: 1190 VEYALK-ARPLRRYIP----KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQS 1244
Query: 1235 DPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFAL 1294
+ + ++++FT +F +E+ +K+IA P ++ N +D L+ +V + +
Sbjct: 1245 CLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAI--TE 1302
Query: 1295 LNAYTYMMGACVIVFRFF------SICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLC 1348
+N + FR F + + ++ LL T + S ++ + + +L
Sbjct: 1303 VNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFI 1362
Query: 1349 YAFAGVVLFGTVKYGE--NINRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQ---PP 1403
YA G+ +FG + + INR+ NF + +A+ +LFR TGE W IM CM P
Sbjct: 1363 YAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAP 1422
Query: 1404 FCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLS 1463
P T T CG+ + A+ YF SFY++ A++++NL VA+I++NF Y T + +L
Sbjct: 1423 ESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFD--YLTRDWSILG 1479
Query: 1464 YNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEV-DLDKDKLLFKHMCYEMERL 1522
+ L F+ IW D + +G I V LLR ++ L L ++ K + L
Sbjct: 1480 PHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPL 1539
Query: 1523 HNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEE----EVAKQTIRMWLKK 1578
++ G V F+ L L ++ I+ A + E E A + +R +KK
Sbjct: 1540 NSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKK 1599
Query: 1579 CLKRIRAK 1586
KR K
Sbjct: 1600 IWKRTSMK 1607
Score = 147 bits (370), Expect = 1e-34
Identities = 149/687 (21%), Positives = 296/687 (43%), Gaps = 102/687 (14%)
Query: 74 LDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIV 133
++ L + ++T E K+ G++ ++Y+++ W + D +V V L + E A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVV---VGLFSAILEQATKA 218
Query: 134 DQMSPWGMLRIPRPLIMIRAFRIYFRFEL----PRTRIT-NILKRSGEQIWSVSIFLLFF 188
D + G + +RAFR+ L P ++ N + ++ + +++ +LF
Sbjct: 219 DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 278
Query: 189 LLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDL 248
+++Y I+G+++F + N +V P C+ E G QC G C
Sbjct: 279 IIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSP---CALETGHGRQCQNGTVCKP- 334
Query: 249 EDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFF 308
G + G + F+ ++ TV++ + EGW ++Y D+ R + YF+TLI
Sbjct: 335 ---GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIII 391
Query: 309 LAWLVKNVFIAVIIETF------AEIRVQFQQM---------------WGSRS------- 340
++ V N+ + V+ F A+ R FQ++ W +++
Sbjct: 392 GSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPEN 451
Query: 341 -------------STTSTATTQMFHEDAAGG-------WQLVAVDVNKPQGRA------P 374
S ++ T + E+ AGG +A ++K +
Sbjct: 452 EDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNR 511
Query: 375 ACLQKM---MRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDL 431
C +K ++S+VF+ ++ +V ++ + AS +Y N+ + + A A LF
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD--TANKALLALFTA 569
Query: 432 EALLKIWCLGFTGYISSSLHKFELLLVIGTTLH-------VYPDLYHSQFTYFQVLRVVR 484
E LLK++ LG Y S ++F+ +V G L + L S ++LR+ +
Sbjct: 570 EMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFK 629
Query: 485 LIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR-------F 537
+ + +L + V + + + SL++ +I+ S + +Q+F D F
Sbjct: 630 ITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTF 689
Query: 538 TTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP--VVAIYFILYHLFATLILLSLFV 595
FP++ +++FQILT E W VM + A G P +V IYFI+ + ILL++F+
Sbjct: 690 DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFL 749
Query: 596 AVILDNLELDEDLKKLKQLKQSE---------ANADTKEKLPLRLRIFEKFPNRPQMVKI 646
A+ +DNL E L ++ ++ E A+ + K++L + + E ++ + +++
Sbjct: 750 AIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE---SKEEKIEL 806
Query: 647 SKLPSDFTVPKIRESFMKQFIDRQQQD 673
+ +D P + M + +D
Sbjct: 807 KSITADGESPPATKINMDDLQPNENED 833
Score = 104 bits (260), Expect = 7e-22
Identities = 94/357 (26%), Positives = 164/357 (45%), Gaps = 62/357 (17%)
Query: 885 VTYLDW----VMIIVTI-CSCISMMFESPFRRVMHAPT---LQIAEYVFVIFMSIELNLK 936
++ ++W ++I++TI +C+++ PF T L+ EY+F+I ++E LK
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 937 IMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQL-----------L 985
++A GL F P A +R+ ++D I +V L F + Q A+ L L
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGL-FSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 986 MVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAK 1045
R LRPLR+ VP ++ V+ + + +++L+L +++++A G++LF GK+ K
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 1046 C-------------NDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWAN 1092
+DP+ E +G N +V K PG W
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCK-------PG-----------WDG 338
Query: 1093 PRN--FNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVG-PIHGIYIHVFVFLGCMIGLT 1149
P++ NFDN AML +F+ ++++GW +V + VG IY + +G L
Sbjct: 339 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLN 398
Query: 1150 LFVGVVIANFNENKGTALLTVD-------QRRWEDLKSRLK-IAQPLHLPPRPDNDG 1198
L +GV+ F++ + A D Q+ EDLK L I Q + P +++G
Sbjct: 399 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEG 455
Score = 98.6 bits (244), Expect = 5e-20
Identities = 125/615 (20%), Positives = 257/615 (41%), Gaps = 86/615 (13%)
Query: 33 INKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHI 92
+N +L+ ++S IS+ P+ +H ++ D + ++T E+I KM
Sbjct: 897 VNDTIFTNLILFFILLSSISLAAEDPV--QHTSFRNHILGNADYVFTSIFTLEIILKMTA 954
Query: 93 RGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIR 152
G S+ ++ + + D L VS+ L F I Q S +++I R L ++R
Sbjct: 955 YGAFLHKGSFCRNYFNILD-----LLVVSVSLISFGI-----QSSAINVVKILRVLRVLR 1004
Query: 153 AFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDT 212
R R + + + + + I ++ I ++ +GVQ+F Y C + +
Sbjct: 1005 PLRAINRAKGLK-HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS-DSS 1062
Query: 213 KPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFT 272
K I T+ E++ P ++ + F+ + ++
Sbjct: 1063 KQTEAECKGNYI--TYKDGEVDHPIIQPRSWENSKFD-------------FDNVLAAMMA 1107
Query: 273 VYEAASQEGWVFLMYRAIDSFPRWRSYFY---------FITLIFFLAWLVKNVFIAVIIE 323
++ ++ EGW L+YR+IDS + Y FI I +A+ + N+F+ +I
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 324 TFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPACLQKMMRS 383
TF E Q +Q + + + + A + + P+ + + ++ S
Sbjct: 1168 TFQE---QGEQEYKNCELDKNQRQCVEYALKARPLRRYI------PKNQHQYKVWYVVNS 1218
Query: 384 SVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFT 443
+ F + ++ ++ I A +Y G++ + + + FT LF +E +LK+
Sbjct: 1219 TYFEYLMFVLILLNTICLAMQHY-GQSCLFKI-AMNILNMLFTGLFTVEMILKLIAFKPK 1276
Query: 444 GYISSSLHKFELLLVIGTTLHVYPDLYHS-------QFTYFQVLRVVRLIKI---SPALE 493
Y + + F+ L+V+G+ + + ++ T+F++ RV+RL+K+ +
Sbjct: 1277 HYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIR 1336
Query: 494 DFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVE-----ELDR---FTTFPRAFM 545
++ + L + + L + + I +Q+F + E++R F TFP+A +
Sbjct: 1337 TLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVL 1396
Query: 546 SMFQILTQEGWVDVMDQTLNAVGHMWAP-----------------VVAIYFILYHLFATL 588
+F+ T E W D+M + G AP YFI +++
Sbjct: 1397 LLFRCATGEAWQDIMLACMP--GKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAF 1454
Query: 589 ILLSLFVAVILDNLE 603
++++LFVAVI+DN +
Sbjct: 1455 LIINLFVAVIMDNFD 1469
Score = 78.2 bits (191), Expect = 7e-14
Identities = 57/250 (22%), Positives = 122/250 (48%), Gaps = 17/250 (6%)
Query: 1206 ITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSP 1265
+ + F+ I L+ L + S ++ + +T T + +F E+ +K+ ++
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1266 AGFWQSRRNRYDLLVTSLGVVWVVL-HFALLNAYTYMMGACVIVFRFFSICGKHVTLKML 1324
++ S NR+D V G++ +L +++ + CV + R F I +L L
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1325 LLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFG-TVKYGENINRHANFSSAGKAITVLF 1383
+ +++ S+ +++ +FL ++ ++ G+ LFG + E R + F + +++ +F
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVF 700
Query: 1384 RIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGAL--MYFCSFYVIIAYIMLNL 1441
+I+TGEDWN +M+D ++ A ++ G L +YF ++ YI+LN+
Sbjct: 701 QILTGEDWNSVMYDGIM-------------AYGGPSFPGMLVCIYFIILFICGNYILLNV 747
Query: 1442 LVAIIVENFS 1451
+AI V+N +
Sbjct: 748 FLAIAVDNLA 757
Score = 58.9 bits (141), Expect = 4e-08
Identities = 68/287 (23%), Positives = 120/287 (41%), Gaps = 68/287 (23%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDTL---LMFLYTAEMIAKMHIRGIVKGDSSYVKD 105
+ V +NT + EHY ++T DT L+ L+TAEM+ KM+ G+ +Y
Sbjct: 531 IFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL----QAYFVS 586
Query: 106 RWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRT 165
+ FD F+V + +L +I MSP G + + R + ++R F+I R+ +
Sbjct: 587 LFNRFDCFVVCGGILETILVETKI------MSPLG-ISVLRCVRLLRIFKIT-RYWNSLS 638
Query: 166 RITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIP 225
+ L S I S+ + L F++++ +LG+Q+FG G ++ +
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFG-------------GKFNFDEM--- 682
Query: 226 DTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFL 285
+ S F+ S+ TV++ + E W +
Sbjct: 683 -------------------------------QTRRSTFDNFPQSLLTVFQILTGEDWNSV 711
Query: 286 MYRAI-----DSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAE 327
MY I SFP YFI L +++ NVF+A+ ++ A+
Sbjct: 712 MYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLAD 758
Score = 51.2 bits (121), Expect = 9e-06
Identities = 64/306 (20%), Positives = 120/306 (39%), Gaps = 62/306 (20%)
Query: 890 WVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
W++I + + +++ E + A + + E+ LK+ + GL ++
Sbjct: 528 WLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSL 587
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVP---QMRKV 1006
F D F+ ++ + + + G + VLRC+R LRIFK+ + +
Sbjct: 588 FNRF----DCFVVCGGILETILVETKIMSPLG---ISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1007 VRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVS 1066
V L + + I + +LL +++F+ G+QLF GK F +
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGK------------------FNFDE- 681
Query: 1067 VSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVR-DVII 1125
R FDN ++L +F++L+ + W V D I+
Sbjct: 682 ------------------------MQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIM 717
Query: 1126 HRVGP-----IHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKS 1180
GP + IY + G I L +F+ + + N + + LT Q+ E+ K
Sbjct: 718 AYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAES---LTSAQKEEEEEKE 774
Query: 1181 RLKIAQ 1186
R K+A+
Sbjct: 775 RKKLAR 780
Score = 48.9 bits (115), Expect = 4e-05
Identities = 57/275 (20%), Positives = 117/275 (42%), Gaps = 57/275 (20%)
Query: 379 KMMRSSVFHMFILSMVTVDVI-VAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKI 437
+++ ++F IL + + I +AA + + +FR A+ FT +F LE +LK+
Sbjct: 895 RIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHI--LGNADYVFTSIFTLEIILKM 952
Query: 438 WCLG---FTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFTYFQVLRVVRL------IKI 488
G G + LLV+ +L + + S ++LRV+R+ I
Sbjct: 953 TAYGAFLHKGSFCRNYFNILDLLVVSVSLISF-GIQSSAINVVKILRVLRVLRPLRAINR 1011
Query: 489 SPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF------CFVE---------- 532
+ L+ V +F + +G++V+ T L + + I +Q+F C
Sbjct: 1012 AKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKG 1071
Query: 533 --------ELDRFTTFPR--------------AFMSMFQILTQEGWVDVMDQTLNAVGHM 570
E+D PR A M++F + T EGW +++ +++++
Sbjct: 1072 NYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTED 1131
Query: 571 WAPV------VAIYFILYHLFATLILLSLFVAVIL 599
P+ ++I+FI+Y + ++++FV ++
Sbjct: 1132 KGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
Score = 41.6 bits (96), Expect = 0.007
Identities = 57/300 (19%), Positives = 110/300 (36%), Gaps = 76/300 (25%)
Query: 1212 FKRTIALLVLAQSVLLSV----KWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMS--- 1264
F+ I L + A V L++ D + L + +F IF +E +K+IA
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLF 185
Query: 1265 -PAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGA-----------CVIVFRFF 1312
P + ++ N D ++ +G+ +L A +G V R
Sbjct: 186 HPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPL 245
Query: 1313 SICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLF--------------- 1357
+ +L+++L +++ +M I + + +++ YA G+ LF
Sbjct: 246 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIA 305
Query: 1358 -----------------------GTV-KYGENINRHA--NFSSAGKAITVLFRIVTGEDW 1391
GTV K G + +H NF + A+ +F+ +T E W
Sbjct: 306 DVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGW 365
Query: 1392 NKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFS 1451
++ YW D +YF + +I ++ +LNL++ ++ FS
Sbjct: 366 TDVL----------------YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS 409
>gi|193794830 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 10 [Homo sapiens]
Length = 2155
Score = 219 bits (559), Expect = 1e-56
Identities = 194/729 (26%), Positives = 346/729 (47%), Gaps = 79/729 (10%)
Query: 891 VMIIVTICSCISMMFESPFRRV-MHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
+++ + S IS+ E P + L A+YVF ++E+ LK+ A G F +
Sbjct: 905 LILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSF 964
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRE 1009
R++ ++D+ + VSLI + ++L VLR LRPLR ++ VV+
Sbjct: 965 CRNYFNILDLLVVSVSLISFGIQSSAINV---VKILRVLRVLRPLRAINRAKGLKHVVQC 1021
Query: 1010 LFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSK 1069
+F + I + I+ L +FA GVQLF GKL C+D + +C G +
Sbjct: 1022 VFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNY-------- 1073
Query: 1070 NLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEV--RDVIIHR 1127
+ + GE PR W N + F+FDNV AM+ALF V + +GW E+ R + H
Sbjct: 1074 ---ITYKDGEVDHPIIQPRSWENSK-FDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHT 1129
Query: 1128 V--GPIHG------IYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLT--VDQRRWED 1177
GPI+ I+ +++ + + +FVG VI F E +D+ + +
Sbjct: 1130 EDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQC 1189
Query: 1178 LKSRLKIAQPL--HLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVED 1235
++ LK A+PL ++P + + K++ + +F+ + +L+L ++ L+++ +
Sbjct: 1190 VEYALK-ARPLRRYIP----KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQS 1244
Query: 1236 PV-TVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVL---- 1290
+ + + ++++FT +F +E+ +K+IA P G++ N +D L+ ++ V+L
Sbjct: 1245 CLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETN 1304
Query: 1291 HFALLNAYTY----MMGACVIV------------------FRFFSIC------GKHVTLK 1322
H+ T+ ++G+ V + FR F + + ++
Sbjct: 1305 HYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIR 1364
Query: 1323 MLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGEN--INRHANFSSAGKAIT 1380
LL T + S ++ + + +L YA G+ +FG + + INR+ NF + +A+
Sbjct: 1365 TLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVL 1424
Query: 1381 VLFRIVTGEDWNKIMHDCMVQP---PFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYI 1437
+LFR TGE W IM CM P P T T CG+ + A+ YF SFY++ A++
Sbjct: 1425 LLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFL 1483
Query: 1438 MLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLL 1497
++NL VA+I++NF Y T + +L + L F+ IW D + +G I V LLR +
Sbjct: 1484 IINLFVAVIMDNFD--YLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRI 1541
Query: 1498 RGRLEV-DLDKDKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAR 1556
+ L L ++ K + L++ G V F+ L L ++ I+ LE+ A
Sbjct: 1542 QPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQ--AN 1599
Query: 1557 EQLEYTIEE 1565
E+L I++
Sbjct: 1600 EELRAIIKK 1608
Score = 147 bits (370), Expect = 1e-34
Identities = 149/687 (21%), Positives = 296/687 (43%), Gaps = 102/687 (14%)
Query: 74 LDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIV 133
++ L + ++T E K+ G++ ++Y+++ W + D +V V L + E A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVV---VGLFSAILEQATKA 218
Query: 134 DQMSPWGMLRIPRPLIMIRAFRIYFRFEL----PRTRIT-NILKRSGEQIWSVSIFLLFF 188
D + G + +RAFR+ L P ++ N + ++ + +++ +LF
Sbjct: 219 DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 278
Query: 189 LLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDL 248
+++Y I+G+++F + N +V P C+ E G QC G C
Sbjct: 279 IIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSP---CALETGHGRQCQNGTVCKP- 334
Query: 249 EDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFF 308
G + G + F+ ++ TV++ + EGW ++Y D+ R + YF+TLI
Sbjct: 335 ---GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIII 391
Query: 309 LAWLVKNVFIAVIIETF------AEIRVQFQQM---------------WGSRS------- 340
++ V N+ + V+ F A+ R FQ++ W +++
Sbjct: 392 GSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPEN 451
Query: 341 -------------STTSTATTQMFHEDAAGG-------WQLVAVDVNKPQGRA------P 374
S ++ T + E+ AGG +A ++K +
Sbjct: 452 EDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNR 511
Query: 375 ACLQKM---MRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDL 431
C +K ++S+VF+ ++ +V ++ + AS +Y N+ + + A A LF
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD--TANKALLALFTA 569
Query: 432 EALLKIWCLGFTGYISSSLHKFELLLVIGTTLH-------VYPDLYHSQFTYFQVLRVVR 484
E LLK++ LG Y S ++F+ +V G L + L S ++LR+ +
Sbjct: 570 EMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFK 629
Query: 485 LIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR-------F 537
+ + +L + V + + + SL++ +I+ S + +Q+F D F
Sbjct: 630 ITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTF 689
Query: 538 TTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP--VVAIYFILYHLFATLILLSLFV 595
FP++ +++FQILT E W VM + A G P +V IYFI+ + ILL++F+
Sbjct: 690 DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFL 749
Query: 596 AVILDNLELDEDLKKLKQLKQSE---------ANADTKEKLPLRLRIFEKFPNRPQMVKI 646
A+ +DNL E L ++ ++ E A+ + K++L + + E ++ + +++
Sbjct: 750 AIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE---SKEEKIEL 806
Query: 647 SKLPSDFTVPKIRESFMKQFIDRQQQD 673
+ +D P + M + +D
Sbjct: 807 KSITADGESPPATKINMDDLQPNENED 833
Score = 104 bits (260), Expect = 7e-22
Identities = 94/357 (26%), Positives = 164/357 (45%), Gaps = 62/357 (17%)
Query: 885 VTYLDW----VMIIVTI-CSCISMMFESPFRRVMHAPT---LQIAEYVFVIFMSIELNLK 936
++ ++W ++I++TI +C+++ PF T L+ EY+F+I ++E LK
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 937 IMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQL-----------L 985
++A GL F P A +R+ ++D I +V L F + Q A+ L L
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGL-FSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 986 MVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAK 1045
R LRPLR+ VP ++ V+ + + +++L+L +++++A G++LF GK+ K
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 1046 C-------------NDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWAN 1092
+DP+ E +G N +V K PG W
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCK-------PG-----------WDG 338
Query: 1093 PRN--FNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVG-PIHGIYIHVFVFLGCMIGLT 1149
P++ NFDN AML +F+ ++++GW +V + VG IY + +G L
Sbjct: 339 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLN 398
Query: 1150 LFVGVVIANFNENKGTALLTVD-------QRRWEDLKSRLK-IAQPLHLPPRPDNDG 1198
L +GV+ F++ + A D Q+ EDLK L I Q + P +++G
Sbjct: 399 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEG 455
Score = 97.4 bits (241), Expect = 1e-19
Identities = 131/643 (20%), Positives = 261/643 (40%), Gaps = 114/643 (17%)
Query: 33 INKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHI 92
+N +L+ ++S IS+ P+ +H ++ D + ++T E+I KM
Sbjct: 897 VNDTIFTNLILFFILLSSISLAAEDPV--QHTSFRNHILGNADYVFTSIFTLEIILKMTA 954
Query: 93 RGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIR 152
G S+ ++ + + D L VS+ L F I Q S +++I R L ++R
Sbjct: 955 YGAFLHKGSFCRNYFNILD-----LLVVSVSLISFGI-----QSSAINVVKILRVLRVLR 1004
Query: 153 AFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDT 212
R R + + + + + I ++ I ++ +GVQ+F Y C + +
Sbjct: 1005 PLRAINRAKGLK-HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS-DSS 1062
Query: 213 KPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFT 272
K I T+ E++ P ++ + F+ + ++
Sbjct: 1063 KQTEAECKGNYI--TYKDGEVDHPIIQPRSWENSKFD-------------FDNVLAAMMA 1107
Query: 273 VYEAASQEGWVFLMYRAIDSFPRWRSYFY---------FITLIFFLAWLVKNVFIAVIIE 323
++ ++ EGW L+YR+IDS + Y FI I +A+ + N+F+ +I
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 324 TFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPACLQKMMRS 383
TF E Q +Q + + + + A + + P+ + + ++ S
Sbjct: 1168 TFQE---QGEQEYKNCELDKNQRQCVEYALKARPLRRYI------PKNQHQYKVWYVVNS 1218
Query: 384 SVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFT 443
+ F + ++ ++ I A +Y G++ + + + FT LF +E +LK+
Sbjct: 1219 TYFEYLMFVLILLNTICLAMQHY-GQSCLFKI-AMNILNMLFTGLFTVEMILKLIAFKPK 1276
Query: 444 GYISSSLHKFELLLVIGT--------TLHVYPDLYHS----------------------- 472
GY S + F+ L+VIG+ T H + D +++
Sbjct: 1277 GYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNNAEE 1336
Query: 473 ----QFTYFQVLRVVRLIKI---SPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISL 525
T+F++ RV+RL+K+ + ++ + L + + L + + I +
Sbjct: 1337 NSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGM 1396
Query: 526 QMFCFVE-----ELDR---FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP---- 573
Q+F + E++R F TFP+A + +F+ T E W D+M + G AP
Sbjct: 1397 QVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMP--GKKCAPESEP 1454
Query: 574 -------------VVAIYFILYHLFATLILLSLFVAVILDNLE 603
YFI +++ ++++LFVAVI+DN +
Sbjct: 1455 SNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFD 1497
Score = 78.2 bits (191), Expect = 7e-14
Identities = 57/250 (22%), Positives = 122/250 (48%), Gaps = 17/250 (6%)
Query: 1206 ITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSP 1265
+ + F+ I L+ L + S ++ + +T T + +F E+ +K+ ++
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1266 AGFWQSRRNRYDLLVTSLGVVWVVL-HFALLNAYTYMMGACVIVFRFFSICGKHVTLKML 1324
++ S NR+D V G++ +L +++ + CV + R F I +L L
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1325 LLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFG-TVKYGENINRHANFSSAGKAITVLF 1383
+ +++ S+ +++ +FL ++ ++ G+ LFG + E R + F + +++ +F
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVF 700
Query: 1384 RIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGAL--MYFCSFYVIIAYIMLNL 1441
+I+TGEDWN +M+D ++ A ++ G L +YF ++ YI+LN+
Sbjct: 701 QILTGEDWNSVMYDGIM-------------AYGGPSFPGMLVCIYFIILFICGNYILLNV 747
Query: 1442 LVAIIVENFS 1451
+AI V+N +
Sbjct: 748 FLAIAVDNLA 757
Score = 58.9 bits (141), Expect = 4e-08
Identities = 68/287 (23%), Positives = 120/287 (41%), Gaps = 68/287 (23%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDTL---LMFLYTAEMIAKMHIRGIVKGDSSYVKD 105
+ V +NT + EHY ++T DT L+ L+TAEM+ KM+ G+ +Y
Sbjct: 531 IFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL----QAYFVS 586
Query: 106 RWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRT 165
+ FD F+V + +L +I MSP G + + R + ++R F+I R+ +
Sbjct: 587 LFNRFDCFVVCGGILETILVETKI------MSPLG-ISVLRCVRLLRIFKIT-RYWNSLS 638
Query: 166 RITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIP 225
+ L S I S+ + L F++++ +LG+Q+FG G ++ +
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFG-------------GKFNFDEM--- 682
Query: 226 DTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFL 285
+ S F+ S+ TV++ + E W +
Sbjct: 683 -------------------------------QTRRSTFDNFPQSLLTVFQILTGEDWNSV 711
Query: 286 MYRAI-----DSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAE 327
MY I SFP YFI L +++ NVF+A+ ++ A+
Sbjct: 712 MYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLAD 758
Score = 51.2 bits (121), Expect = 9e-06
Identities = 64/306 (20%), Positives = 120/306 (39%), Gaps = 62/306 (20%)
Query: 890 WVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
W++I + + +++ E + A + + E+ LK+ + GL ++
Sbjct: 528 WLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSL 587
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVP---QMRKV 1006
F D F+ ++ + + + G + VLRC+R LRIFK+ + +
Sbjct: 588 FNRF----DCFVVCGGILETILVETKIMSPLG---ISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1007 VRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVS 1066
V L + + I + +LL +++F+ G+QLF GK F +
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGK------------------FNFDE- 681
Query: 1067 VSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVR-DVII 1125
R FDN ++L +F++L+ + W V D I+
Sbjct: 682 ------------------------MQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIM 717
Query: 1126 HRVGP-----IHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKS 1180
GP + IY + G I L +F+ + + N + + LT Q+ E+ K
Sbjct: 718 AYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAES---LTSAQKEEEEEKE 774
Query: 1181 RLKIAQ 1186
R K+A+
Sbjct: 775 RKKLAR 780
Score = 48.9 bits (115), Expect = 4e-05
Identities = 57/275 (20%), Positives = 117/275 (42%), Gaps = 57/275 (20%)
Query: 379 KMMRSSVFHMFILSMVTVDVI-VAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKI 437
+++ ++F IL + + I +AA + + +FR A+ FT +F LE +LK+
Sbjct: 895 RIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHI--LGNADYVFTSIFTLEIILKM 952
Query: 438 WCLG---FTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFTYFQVLRVVRL------IKI 488
G G + LLV+ +L + + S ++LRV+R+ I
Sbjct: 953 TAYGAFLHKGSFCRNYFNILDLLVVSVSLISF-GIQSSAINVVKILRVLRVLRPLRAINR 1011
Query: 489 SPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF------CFVE---------- 532
+ L+ V +F + +G++V+ T L + + I +Q+F C
Sbjct: 1012 AKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKG 1071
Query: 533 --------ELDRFTTFPR--------------AFMSMFQILTQEGWVDVMDQTLNAVGHM 570
E+D PR A M++F + T EGW +++ +++++
Sbjct: 1072 NYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTED 1131
Query: 571 WAPV------VAIYFILYHLFATLILLSLFVAVIL 599
P+ ++I+FI+Y + ++++FV ++
Sbjct: 1132 KGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
Score = 41.6 bits (96), Expect = 0.007
Identities = 57/300 (19%), Positives = 110/300 (36%), Gaps = 76/300 (25%)
Query: 1212 FKRTIALLVLAQSVLLSV----KWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMS--- 1264
F+ I L + A V L++ D + L + +F IF +E +K+IA
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLF 185
Query: 1265 -PAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGA-----------CVIVFRFF 1312
P + ++ N D ++ +G+ +L A +G V R
Sbjct: 186 HPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPL 245
Query: 1313 SICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLF--------------- 1357
+ +L+++L +++ +M I + + +++ YA G+ LF
Sbjct: 246 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIA 305
Query: 1358 -----------------------GTV-KYGENINRHA--NFSSAGKAITVLFRIVTGEDW 1391
GTV K G + +H NF + A+ +F+ +T E W
Sbjct: 306 DVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGW 365
Query: 1392 NKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFS 1451
++ YW D +YF + +I ++ +LNL++ ++ FS
Sbjct: 366 TDVL----------------YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS 409
>gi|193788730 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 4 [Homo sapiens]
Length = 2173
Score = 218 bits (556), Expect = 3e-56
Identities = 189/712 (26%), Positives = 338/712 (47%), Gaps = 62/712 (8%)
Query: 891 VMIIVTICSCISMMFESPFRRV-MHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
+++ + S IS+ E P + L A+YVF ++E+ LK+ A G F +
Sbjct: 905 LILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSF 964
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRE 1009
R++ ++D+ + VSLI + ++L VLR LRPLR ++ VV+
Sbjct: 965 CRNYFNILDLLVVSVSLISFGIQSSAINV---VKILRVLRVLRPLRAINRAKGLKHVVQC 1021
Query: 1010 LFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSK 1069
+F + I + I+ L +FA GVQLF GKL C+D + +C G +
Sbjct: 1022 VFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNY-------- 1073
Query: 1070 NLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEV--RDVIIHR 1127
+ + GE PR W N + F+FDNV AM+ALF V + +GW E+ R + H
Sbjct: 1074 ---ITYKDGEVDHPIIQPRSWENSK-FDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHT 1129
Query: 1128 --VGPIH------GIYIHVFVFLGCMIGLTLFVGVVIANFNE--NKGTALLTVDQRRWED 1177
GPI+ I+ +++ + + +FVG VI F E + +D+ + +
Sbjct: 1130 EDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQC 1189
Query: 1178 LKSRLKIAQPL--HLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVK-WDVE 1234
++ LK A+PL ++P + + K++ + +F+ + +L+L ++ L+++ +
Sbjct: 1190 VEYALK-ARPLRRYIP----KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQS 1244
Query: 1235 DPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFAL 1294
+ + ++++FT +F +E+ +K+IA P ++ N +D L+ +V + +
Sbjct: 1245 CLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVN 1304
Query: 1295 LNAYTYMMGA---------CVIVFRFF------SICGKHVTLKMLLLTVVVSMYKSFFII 1339
+T + + FR F + + ++ LL T + S ++
Sbjct: 1305 PAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVA 1364
Query: 1340 VGMFLLLLCYAFAGVVLFGTVKYGE--NINRHANFSSAGKAITVLFRIVTGEDWNKIMHD 1397
+ + +L YA G+ +FG + + INR+ NF + +A+ +LFR TGE W IM
Sbjct: 1365 LLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLA 1424
Query: 1398 CMVQ---PPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFY 1454
CM P P T T CG+ + A+ YF SFY++ A++++NL VA+I++NF Y
Sbjct: 1425 CMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFD--Y 1481
Query: 1455 STEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEV-DLDKDKLLFK 1513
T + +L + L F+ IW D + +G I V LLR ++ L L ++ K
Sbjct: 1482 LTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACK 1541
Query: 1514 HMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEE 1565
+ L++ G V F+ L L ++ I+ LE+ A E+L I++
Sbjct: 1542 RLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQ--ANEELRAIIKK 1591
Score = 147 bits (370), Expect = 1e-34
Identities = 149/687 (21%), Positives = 296/687 (43%), Gaps = 102/687 (14%)
Query: 74 LDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIV 133
++ L + ++T E K+ G++ ++Y+++ W + D +V V L + E A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVV---VGLFSAILEQATKA 218
Query: 134 DQMSPWGMLRIPRPLIMIRAFRIYFRFEL----PRTRIT-NILKRSGEQIWSVSIFLLFF 188
D + G + +RAFR+ L P ++ N + ++ + +++ +LF
Sbjct: 219 DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 278
Query: 189 LLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDL 248
+++Y I+G+++F + N +V P C+ E G QC G C
Sbjct: 279 IIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSP---CALETGHGRQCQNGTVCKP- 334
Query: 249 EDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFF 308
G + G + F+ ++ TV++ + EGW ++Y D+ R + YF+TLI
Sbjct: 335 ---GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIII 391
Query: 309 LAWLVKNVFIAVIIETF------AEIRVQFQQM---------------WGSRS------- 340
++ V N+ + V+ F A+ R FQ++ W +++
Sbjct: 392 GSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPEN 451
Query: 341 -------------STTSTATTQMFHEDAAGG-------WQLVAVDVNKPQGRA------P 374
S ++ T + E+ AGG +A ++K +
Sbjct: 452 EDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNR 511
Query: 375 ACLQKM---MRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDL 431
C +K ++S+VF+ ++ +V ++ + AS +Y N+ + + A A LF
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD--TANKALLALFTA 569
Query: 432 EALLKIWCLGFTGYISSSLHKFELLLVIGTTLH-------VYPDLYHSQFTYFQVLRVVR 484
E LLK++ LG Y S ++F+ +V G L + L S ++LR+ +
Sbjct: 570 EMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFK 629
Query: 485 LIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR-------F 537
+ + +L + V + + + SL++ +I+ S + +Q+F D F
Sbjct: 630 ITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTF 689
Query: 538 TTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP--VVAIYFILYHLFATLILLSLFV 595
FP++ +++FQILT E W VM + A G P +V IYFI+ + ILL++F+
Sbjct: 690 DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFL 749
Query: 596 AVILDNLELDEDLKKLKQLKQSE---------ANADTKEKLPLRLRIFEKFPNRPQMVKI 646
A+ +DNL E L ++ ++ E A+ + K++L + + E ++ + +++
Sbjct: 750 AIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE---SKEEKIEL 806
Query: 647 SKLPSDFTVPKIRESFMKQFIDRQQQD 673
+ +D P + M + +D
Sbjct: 807 KSITADGESPPATKINMDDLQPNENED 833
Score = 104 bits (260), Expect = 7e-22
Identities = 94/357 (26%), Positives = 164/357 (45%), Gaps = 62/357 (17%)
Query: 885 VTYLDW----VMIIVTI-CSCISMMFESPFRRVMHAPT---LQIAEYVFVIFMSIELNLK 936
++ ++W ++I++TI +C+++ PF T L+ EY+F+I ++E LK
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 937 IMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQL-----------L 985
++A GL F P A +R+ ++D I +V L F + Q A+ L L
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGL-FSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 986 MVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAK 1045
R LRPLR+ VP ++ V+ + + +++L+L +++++A G++LF GK+ K
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 1046 C-------------NDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWAN 1092
+DP+ E +G N +V K PG W
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCK-------PG-----------WDG 338
Query: 1093 PRN--FNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVG-PIHGIYIHVFVFLGCMIGLT 1149
P++ NFDN AML +F+ ++++GW +V + VG IY + +G L
Sbjct: 339 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLN 398
Query: 1150 LFVGVVIANFNENKGTALLTVD-------QRRWEDLKSRLK-IAQPLHLPPRPDNDG 1198
L +GV+ F++ + A D Q+ EDLK L I Q + P +++G
Sbjct: 399 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEG 455
Score = 95.9 bits (237), Expect = 3e-19
Identities = 127/626 (20%), Positives = 258/626 (41%), Gaps = 97/626 (15%)
Query: 33 INKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHI 92
+N +L+ ++S IS+ P+ +H ++ D + ++T E+I KM
Sbjct: 897 VNDTIFTNLILFFILLSSISLAAEDPV--QHTSFRNHILGNADYVFTSIFTLEIILKMTA 954
Query: 93 RGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIR 152
G S+ ++ + + D L VS+ L F I Q S +++I R L ++R
Sbjct: 955 YGAFLHKGSFCRNYFNILD-----LLVVSVSLISFGI-----QSSAINVVKILRVLRVLR 1004
Query: 153 AFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDT 212
R R + + + + + I ++ I ++ +GVQ+F Y C + +
Sbjct: 1005 PLRAINRAKGLK-HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS-DSS 1062
Query: 213 KPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFT 272
K I T+ E++ P ++ + F+ + ++
Sbjct: 1063 KQTEAECKGNYI--TYKDGEVDHPIIQPRSWENSKFD-------------FDNVLAAMMA 1107
Query: 273 VYEAASQEGWVFLMYRAIDSFPRWRSYFY---------FITLIFFLAWLVKNVFIAVIIE 323
++ ++ EGW L+YR+IDS + Y FI I +A+ + N+F+ +I
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 324 TFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPACLQKMMRS 383
TF E Q +Q + + + + A + + P+ + + ++ S
Sbjct: 1168 TFQE---QGEQEYKNCELDKNQRQCVEYALKARPLRRYI------PKNQHQYKVWYVVNS 1218
Query: 384 SVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFT 443
+ F + ++ ++ I A +Y G++ + + + FT LF +E +LK+
Sbjct: 1219 TYFEYLMFVLILLNTICLAMQHY-GQSCLFKI-AMNILNMLFTGLFTVEMILKLIAFKPK 1276
Query: 444 GYISSSLHKFELLLVIGTTLHV----YPDLYHSQ--------------FTYFQVLRVVRL 485
Y + + F+ L+V+G+ + + H+Q T+F++ RV+RL
Sbjct: 1277 HYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRL 1336
Query: 486 IKI---SPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVE-----ELDR- 536
+K+ + ++ + L + + L + + I +Q+F + E++R
Sbjct: 1337 VKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRN 1396
Query: 537 --FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP-----------------VVAI 577
F TFP+A + +F+ T E W D+M + G AP
Sbjct: 1397 NNFQTFPQAVLLLFRCATGEAWQDIMLACMP--GKKCAPESEPSNSTEGETPCGSSFAVF 1454
Query: 578 YFILYHLFATLILLSLFVAVILDNLE 603
YFI +++ ++++LFVAVI+DN +
Sbjct: 1455 YFISFYMLCAFLIINLFVAVIMDNFD 1480
Score = 78.2 bits (191), Expect = 7e-14
Identities = 57/250 (22%), Positives = 122/250 (48%), Gaps = 17/250 (6%)
Query: 1206 ITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSP 1265
+ + F+ I L+ L + S ++ + +T T + +F E+ +K+ ++
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1266 AGFWQSRRNRYDLLVTSLGVVWVVL-HFALLNAYTYMMGACVIVFRFFSICGKHVTLKML 1324
++ S NR+D V G++ +L +++ + CV + R F I +L L
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1325 LLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFG-TVKYGENINRHANFSSAGKAITVLF 1383
+ +++ S+ +++ +FL ++ ++ G+ LFG + E R + F + +++ +F
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVF 700
Query: 1384 RIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGAL--MYFCSFYVIIAYIMLNL 1441
+I+TGEDWN +M+D ++ A ++ G L +YF ++ YI+LN+
Sbjct: 701 QILTGEDWNSVMYDGIM-------------AYGGPSFPGMLVCIYFIILFICGNYILLNV 747
Query: 1442 LVAIIVENFS 1451
+AI V+N +
Sbjct: 748 FLAIAVDNLA 757
Score = 58.9 bits (141), Expect = 4e-08
Identities = 68/287 (23%), Positives = 120/287 (41%), Gaps = 68/287 (23%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDTL---LMFLYTAEMIAKMHIRGIVKGDSSYVKD 105
+ V +NT + EHY ++T DT L+ L+TAEM+ KM+ G+ +Y
Sbjct: 531 IFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL----QAYFVS 586
Query: 106 RWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRT 165
+ FD F+V + +L +I MSP G + + R + ++R F+I R+ +
Sbjct: 587 LFNRFDCFVVCGGILETILVETKI------MSPLG-ISVLRCVRLLRIFKIT-RYWNSLS 638
Query: 166 RITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIP 225
+ L S I S+ + L F++++ +LG+Q+FG G ++ +
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFG-------------GKFNFDEM--- 682
Query: 226 DTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFL 285
+ S F+ S+ TV++ + E W +
Sbjct: 683 -------------------------------QTRRSTFDNFPQSLLTVFQILTGEDWNSV 711
Query: 286 MYRAI-----DSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAE 327
MY I SFP YFI L +++ NVF+A+ ++ A+
Sbjct: 712 MYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLAD 758
Score = 51.2 bits (121), Expect = 9e-06
Identities = 64/306 (20%), Positives = 120/306 (39%), Gaps = 62/306 (20%)
Query: 890 WVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
W++I + + +++ E + A + + E+ LK+ + GL ++
Sbjct: 528 WLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSL 587
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVP---QMRKV 1006
F D F+ ++ + + + G + VLRC+R LRIFK+ + +
Sbjct: 588 FNRF----DCFVVCGGILETILVETKIMSPLG---ISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1007 VRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVS 1066
V L + + I + +LL +++F+ G+QLF GK F +
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGK------------------FNFDE- 681
Query: 1067 VSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVR-DVII 1125
R FDN ++L +F++L+ + W V D I+
Sbjct: 682 ------------------------MQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIM 717
Query: 1126 HRVGP-----IHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKS 1180
GP + IY + G I L +F+ + + N + + LT Q+ E+ K
Sbjct: 718 AYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAES---LTSAQKEEEEEKE 774
Query: 1181 RLKIAQ 1186
R K+A+
Sbjct: 775 RKKLAR 780
Score = 48.9 bits (115), Expect = 4e-05
Identities = 57/275 (20%), Positives = 117/275 (42%), Gaps = 57/275 (20%)
Query: 379 KMMRSSVFHMFILSMVTVDVI-VAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKI 437
+++ ++F IL + + I +AA + + +FR A+ FT +F LE +LK+
Sbjct: 895 RIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHI--LGNADYVFTSIFTLEIILKM 952
Query: 438 WCLG---FTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFTYFQVLRVVRL------IKI 488
G G + LLV+ +L + + S ++LRV+R+ I
Sbjct: 953 TAYGAFLHKGSFCRNYFNILDLLVVSVSLISF-GIQSSAINVVKILRVLRVLRPLRAINR 1011
Query: 489 SPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF------CFVE---------- 532
+ L+ V +F + +G++V+ T L + + I +Q+F C
Sbjct: 1012 AKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKG 1071
Query: 533 --------ELDRFTTFPR--------------AFMSMFQILTQEGWVDVMDQTLNAVGHM 570
E+D PR A M++F + T EGW +++ +++++
Sbjct: 1072 NYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTED 1131
Query: 571 WAPV------VAIYFILYHLFATLILLSLFVAVIL 599
P+ ++I+FI+Y + ++++FV ++
Sbjct: 1132 KGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
Score = 41.6 bits (96), Expect = 0.007
Identities = 57/300 (19%), Positives = 110/300 (36%), Gaps = 76/300 (25%)
Query: 1212 FKRTIALLVLAQSVLLSV----KWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMS--- 1264
F+ I L + A V L++ D + L + +F IF +E +K+IA
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLF 185
Query: 1265 -PAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGA-----------CVIVFRFF 1312
P + ++ N D ++ +G+ +L A +G V R
Sbjct: 186 HPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPL 245
Query: 1313 SICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLF--------------- 1357
+ +L+++L +++ +M I + + +++ YA G+ LF
Sbjct: 246 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIA 305
Query: 1358 -----------------------GTV-KYGENINRHA--NFSSAGKAITVLFRIVTGEDW 1391
GTV K G + +H NF + A+ +F+ +T E W
Sbjct: 306 DVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGW 365
Query: 1392 NKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFS 1451
++ YW D +YF + +I ++ +LNL++ ++ FS
Sbjct: 366 TDVL----------------YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS 409
>gi|193788542 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 17 [Homo sapiens]
Length = 2138
Score = 218 bits (556), Expect = 3e-56
Identities = 189/712 (26%), Positives = 338/712 (47%), Gaps = 62/712 (8%)
Query: 891 VMIIVTICSCISMMFESPFRRV-MHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
+++ + S IS+ E P + L A+YVF ++E+ LK+ A G F +
Sbjct: 905 LILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSF 964
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRE 1009
R++ ++D+ + VSLI + ++L VLR LRPLR ++ VV+
Sbjct: 965 CRNYFNILDLLVVSVSLISFGIQSSAINV---VKILRVLRVLRPLRAINRAKGLKHVVQC 1021
Query: 1010 LFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSK 1069
+F + I + I+ L +FA GVQLF GKL C+D + +C G +
Sbjct: 1022 VFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNY-------- 1073
Query: 1070 NLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEV--RDVIIHR 1127
+ + GE PR W N + F+FDNV AM+ALF V + +GW E+ R + H
Sbjct: 1074 ---ITYKDGEVDHPIIQPRSWENSK-FDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHT 1129
Query: 1128 --VGPIH------GIYIHVFVFLGCMIGLTLFVGVVIANFNE--NKGTALLTVDQRRWED 1177
GPI+ I+ +++ + + +FVG VI F E + +D+ + +
Sbjct: 1130 EDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQC 1189
Query: 1178 LKSRLKIAQPL--HLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVK-WDVE 1234
++ LK A+PL ++P + + K++ + +F+ + +L+L ++ L+++ +
Sbjct: 1190 VEYALK-ARPLRRYIP----KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQS 1244
Query: 1235 DPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFAL 1294
+ + ++++FT +F +E+ +K+IA P ++ N +D L+ +V + +
Sbjct: 1245 CLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVN 1304
Query: 1295 LNAYTYMMGA---------CVIVFRFF------SICGKHVTLKMLLLTVVVSMYKSFFII 1339
+T + + FR F + + ++ LL T + S ++
Sbjct: 1305 PAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVA 1364
Query: 1340 VGMFLLLLCYAFAGVVLFGTVKYGE--NINRHANFSSAGKAITVLFRIVTGEDWNKIMHD 1397
+ + +L YA G+ +FG + + INR+ NF + +A+ +LFR TGE W IM
Sbjct: 1365 LLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLA 1424
Query: 1398 CMVQ---PPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFY 1454
CM P P T T CG+ + A+ YF SFY++ A++++NL VA+I++NF Y
Sbjct: 1425 CMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFD--Y 1481
Query: 1455 STEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEV-DLDKDKLLFK 1513
T + +L + L F+ IW D + +G I V LLR ++ L L ++ K
Sbjct: 1482 LTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACK 1541
Query: 1514 HMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEE 1565
+ L++ G V F+ L L ++ I+ LE+ A E+L I++
Sbjct: 1542 RLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQ--ANEELRAIIKK 1591
Score = 147 bits (370), Expect = 1e-34
Identities = 149/687 (21%), Positives = 296/687 (43%), Gaps = 102/687 (14%)
Query: 74 LDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIV 133
++ L + ++T E K+ G++ ++Y+++ W + D +V V L + E A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVV---VGLFSAILEQATKA 218
Query: 134 DQMSPWGMLRIPRPLIMIRAFRIYFRFEL----PRTRIT-NILKRSGEQIWSVSIFLLFF 188
D + G + +RAFR+ L P ++ N + ++ + +++ +LF
Sbjct: 219 DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 278
Query: 189 LLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDL 248
+++Y I+G+++F + N +V P C+ E G QC G C
Sbjct: 279 IIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSP---CALETGHGRQCQNGTVCKP- 334
Query: 249 EDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFF 308
G + G + F+ ++ TV++ + EGW ++Y D+ R + YF+TLI
Sbjct: 335 ---GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIII 391
Query: 309 LAWLVKNVFIAVIIETF------AEIRVQFQQM---------------WGSRS------- 340
++ V N+ + V+ F A+ R FQ++ W +++
Sbjct: 392 GSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPEN 451
Query: 341 -------------STTSTATTQMFHEDAAGG-------WQLVAVDVNKPQGRA------P 374
S ++ T + E+ AGG +A ++K +
Sbjct: 452 EDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNR 511
Query: 375 ACLQKM---MRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDL 431
C +K ++S+VF+ ++ +V ++ + AS +Y N+ + + A A LF
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD--TANKALLALFTA 569
Query: 432 EALLKIWCLGFTGYISSSLHKFELLLVIGTTLH-------VYPDLYHSQFTYFQVLRVVR 484
E LLK++ LG Y S ++F+ +V G L + L S ++LR+ +
Sbjct: 570 EMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFK 629
Query: 485 LIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR-------F 537
+ + +L + V + + + SL++ +I+ S + +Q+F D F
Sbjct: 630 ITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTF 689
Query: 538 TTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP--VVAIYFILYHLFATLILLSLFV 595
FP++ +++FQILT E W VM + A G P +V IYFI+ + ILL++F+
Sbjct: 690 DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFL 749
Query: 596 AVILDNLELDEDLKKLKQLKQSE---------ANADTKEKLPLRLRIFEKFPNRPQMVKI 646
A+ +DNL E L ++ ++ E A+ + K++L + + E ++ + +++
Sbjct: 750 AIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE---SKEEKIEL 806
Query: 647 SKLPSDFTVPKIRESFMKQFIDRQQQD 673
+ +D P + M + +D
Sbjct: 807 KSITADGESPPATKINMDDLQPNENED 833
Score = 104 bits (260), Expect = 7e-22
Identities = 94/357 (26%), Positives = 164/357 (45%), Gaps = 62/357 (17%)
Query: 885 VTYLDW----VMIIVTI-CSCISMMFESPFRRVMHAPT---LQIAEYVFVIFMSIELNLK 936
++ ++W ++I++TI +C+++ PF T L+ EY+F+I ++E LK
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 937 IMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQL-----------L 985
++A GL F P A +R+ ++D I +V L F + Q A+ L L
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGL-FSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 986 MVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAK 1045
R LRPLR+ VP ++ V+ + + +++L+L +++++A G++LF GK+ K
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 1046 C-------------NDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWAN 1092
+DP+ E +G N +V K PG W
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCK-------PG-----------WDG 338
Query: 1093 PRN--FNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVG-PIHGIYIHVFVFLGCMIGLT 1149
P++ NFDN AML +F+ ++++GW +V + VG IY + +G L
Sbjct: 339 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLN 398
Query: 1150 LFVGVVIANFNENKGTALLTVD-------QRRWEDLKSRLK-IAQPLHLPPRPDNDG 1198
L +GV+ F++ + A D Q+ EDLK L I Q + P +++G
Sbjct: 399 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEG 455
Score = 95.9 bits (237), Expect = 3e-19
Identities = 127/626 (20%), Positives = 258/626 (41%), Gaps = 97/626 (15%)
Query: 33 INKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHI 92
+N +L+ ++S IS+ P+ +H ++ D + ++T E+I KM
Sbjct: 897 VNDTIFTNLILFFILLSSISLAAEDPV--QHTSFRNHILGNADYVFTSIFTLEIILKMTA 954
Query: 93 RGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIR 152
G S+ ++ + + D L VS+ L F I Q S +++I R L ++R
Sbjct: 955 YGAFLHKGSFCRNYFNILD-----LLVVSVSLISFGI-----QSSAINVVKILRVLRVLR 1004
Query: 153 AFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDT 212
R R + + + + + I ++ I ++ +GVQ+F Y C + +
Sbjct: 1005 PLRAINRAKGLK-HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS-DSS 1062
Query: 213 KPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFT 272
K I T+ E++ P ++ + F+ + ++
Sbjct: 1063 KQTEAECKGNYI--TYKDGEVDHPIIQPRSWENSKFD-------------FDNVLAAMMA 1107
Query: 273 VYEAASQEGWVFLMYRAIDSFPRWRSYFY---------FITLIFFLAWLVKNVFIAVIIE 323
++ ++ EGW L+YR+IDS + Y FI I +A+ + N+F+ +I
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 324 TFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPACLQKMMRS 383
TF E Q +Q + + + + A + + P+ + + ++ S
Sbjct: 1168 TFQE---QGEQEYKNCELDKNQRQCVEYALKARPLRRYI------PKNQHQYKVWYVVNS 1218
Query: 384 SVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFT 443
+ F + ++ ++ I A +Y G++ + + + FT LF +E +LK+
Sbjct: 1219 TYFEYLMFVLILLNTICLAMQHY-GQSCLFKI-AMNILNMLFTGLFTVEMILKLIAFKPK 1276
Query: 444 GYISSSLHKFELLLVIGTTLHV----YPDLYHSQ--------------FTYFQVLRVVRL 485
Y + + F+ L+V+G+ + + H+Q T+F++ RV+RL
Sbjct: 1277 HYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRL 1336
Query: 486 IKI---SPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVE-----ELDR- 536
+K+ + ++ + L + + L + + I +Q+F + E++R
Sbjct: 1337 VKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRN 1396
Query: 537 --FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP-----------------VVAI 577
F TFP+A + +F+ T E W D+M + G AP
Sbjct: 1397 NNFQTFPQAVLLLFRCATGEAWQDIMLACMP--GKKCAPESEPSNSTEGETPCGSSFAVF 1454
Query: 578 YFILYHLFATLILLSLFVAVILDNLE 603
YFI +++ ++++LFVAVI+DN +
Sbjct: 1455 YFISFYMLCAFLIINLFVAVIMDNFD 1480
Score = 78.2 bits (191), Expect = 7e-14
Identities = 57/250 (22%), Positives = 122/250 (48%), Gaps = 17/250 (6%)
Query: 1206 ITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSP 1265
+ + F+ I L+ L + S ++ + +T T + +F E+ +K+ ++
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1266 AGFWQSRRNRYDLLVTSLGVVWVVL-HFALLNAYTYMMGACVIVFRFFSICGKHVTLKML 1324
++ S NR+D V G++ +L +++ + CV + R F I +L L
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1325 LLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFG-TVKYGENINRHANFSSAGKAITVLF 1383
+ +++ S+ +++ +FL ++ ++ G+ LFG + E R + F + +++ +F
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVF 700
Query: 1384 RIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGAL--MYFCSFYVIIAYIMLNL 1441
+I+TGEDWN +M+D ++ A ++ G L +YF ++ YI+LN+
Sbjct: 701 QILTGEDWNSVMYDGIM-------------AYGGPSFPGMLVCIYFIILFICGNYILLNV 747
Query: 1442 LVAIIVENFS 1451
+AI V+N +
Sbjct: 748 FLAIAVDNLA 757
Score = 58.9 bits (141), Expect = 4e-08
Identities = 68/287 (23%), Positives = 120/287 (41%), Gaps = 68/287 (23%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDTL---LMFLYTAEMIAKMHIRGIVKGDSSYVKD 105
+ V +NT + EHY ++T DT L+ L+TAEM+ KM+ G+ +Y
Sbjct: 531 IFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL----QAYFVS 586
Query: 106 RWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRT 165
+ FD F+V + +L +I MSP G + + R + ++R F+I R+ +
Sbjct: 587 LFNRFDCFVVCGGILETILVETKI------MSPLG-ISVLRCVRLLRIFKIT-RYWNSLS 638
Query: 166 RITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIP 225
+ L S I S+ + L F++++ +LG+Q+FG G ++ +
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFG-------------GKFNFDEM--- 682
Query: 226 DTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFL 285
+ S F+ S+ TV++ + E W +
Sbjct: 683 -------------------------------QTRRSTFDNFPQSLLTVFQILTGEDWNSV 711
Query: 286 MYRAI-----DSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAE 327
MY I SFP YFI L +++ NVF+A+ ++ A+
Sbjct: 712 MYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLAD 758
Score = 51.2 bits (121), Expect = 9e-06
Identities = 64/306 (20%), Positives = 120/306 (39%), Gaps = 62/306 (20%)
Query: 890 WVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
W++I + + +++ E + A + + E+ LK+ + GL ++
Sbjct: 528 WLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSL 587
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVP---QMRKV 1006
F D F+ ++ + + + G + VLRC+R LRIFK+ + +
Sbjct: 588 FNRF----DCFVVCGGILETILVETKIMSPLG---ISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1007 VRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVS 1066
V L + + I + +LL +++F+ G+QLF GK F +
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGK------------------FNFDE- 681
Query: 1067 VSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVR-DVII 1125
R FDN ++L +F++L+ + W V D I+
Sbjct: 682 ------------------------MQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIM 717
Query: 1126 HRVGP-----IHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKS 1180
GP + IY + G I L +F+ + + N + + LT Q+ E+ K
Sbjct: 718 AYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAES---LTSAQKEEEEEKE 774
Query: 1181 RLKIAQ 1186
R K+A+
Sbjct: 775 RKKLAR 780
Score = 48.9 bits (115), Expect = 4e-05
Identities = 57/275 (20%), Positives = 117/275 (42%), Gaps = 57/275 (20%)
Query: 379 KMMRSSVFHMFILSMVTVDVI-VAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKI 437
+++ ++F IL + + I +AA + + +FR A+ FT +F LE +LK+
Sbjct: 895 RIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHI--LGNADYVFTSIFTLEIILKM 952
Query: 438 WCLG---FTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFTYFQVLRVVRL------IKI 488
G G + LLV+ +L + + S ++LRV+R+ I
Sbjct: 953 TAYGAFLHKGSFCRNYFNILDLLVVSVSLISF-GIQSSAINVVKILRVLRVLRPLRAINR 1011
Query: 489 SPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF------CFVE---------- 532
+ L+ V +F + +G++V+ T L + + I +Q+F C
Sbjct: 1012 AKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKG 1071
Query: 533 --------ELDRFTTFPR--------------AFMSMFQILTQEGWVDVMDQTLNAVGHM 570
E+D PR A M++F + T EGW +++ +++++
Sbjct: 1072 NYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTED 1131
Query: 571 WAPV------VAIYFILYHLFATLILLSLFVAVIL 599
P+ ++I+FI+Y + ++++FV ++
Sbjct: 1132 KGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
Score = 41.6 bits (96), Expect = 0.007
Identities = 57/300 (19%), Positives = 110/300 (36%), Gaps = 76/300 (25%)
Query: 1212 FKRTIALLVLAQSVLLSV----KWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMS--- 1264
F+ I L + A V L++ D + L + +F IF +E +K+IA
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLF 185
Query: 1265 -PAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGA-----------CVIVFRFF 1312
P + ++ N D ++ +G+ +L A +G V R
Sbjct: 186 HPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPL 245
Query: 1313 SICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLF--------------- 1357
+ +L+++L +++ +M I + + +++ YA G+ LF
Sbjct: 246 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIA 305
Query: 1358 -----------------------GTV-KYGENINRHA--NFSSAGKAITVLFRIVTGEDW 1391
GTV K G + +H NF + A+ +F+ +T E W
Sbjct: 306 DVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGW 365
Query: 1392 NKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFS 1451
++ YW D +YF + +I ++ +LNL++ ++ FS
Sbjct: 366 TDVL----------------YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS 409
>gi|193788536 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 14 [Homo sapiens]
Length = 2138
Score = 218 bits (556), Expect = 3e-56
Identities = 189/712 (26%), Positives = 338/712 (47%), Gaps = 62/712 (8%)
Query: 891 VMIIVTICSCISMMFESPFRRV-MHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
+++ + S IS+ E P + L A+YVF ++E+ LK+ A G F +
Sbjct: 905 LILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSF 964
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRE 1009
R++ ++D+ + VSLI + ++L VLR LRPLR ++ VV+
Sbjct: 965 CRNYFNILDLLVVSVSLISFGIQSSAINV---VKILRVLRVLRPLRAINRAKGLKHVVQC 1021
Query: 1010 LFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSK 1069
+F + I + I+ L +FA GVQLF GKL C+D + +C G +
Sbjct: 1022 VFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNY-------- 1073
Query: 1070 NLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEV--RDVIIHR 1127
+ + GE PR W N + F+FDNV AM+ALF V + +GW E+ R + H
Sbjct: 1074 ---ITYKDGEVDHPIIQPRSWENSK-FDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHT 1129
Query: 1128 --VGPIH------GIYIHVFVFLGCMIGLTLFVGVVIANFNE--NKGTALLTVDQRRWED 1177
GPI+ I+ +++ + + +FVG VI F E + +D+ + +
Sbjct: 1130 EDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQC 1189
Query: 1178 LKSRLKIAQPL--HLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVK-WDVE 1234
++ LK A+PL ++P + + K++ + +F+ + +L+L ++ L+++ +
Sbjct: 1190 VEYALK-ARPLRRYIP----KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQS 1244
Query: 1235 DPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFAL 1294
+ + ++++FT +F +E+ +K+IA P ++ N +D L+ +V + +
Sbjct: 1245 CLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVN 1304
Query: 1295 LNAYTYMMGA---------CVIVFRFF------SICGKHVTLKMLLLTVVVSMYKSFFII 1339
+T + + FR F + + ++ LL T + S ++
Sbjct: 1305 PAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVA 1364
Query: 1340 VGMFLLLLCYAFAGVVLFGTVKYGE--NINRHANFSSAGKAITVLFRIVTGEDWNKIMHD 1397
+ + +L YA G+ +FG + + INR+ NF + +A+ +LFR TGE W IM
Sbjct: 1365 LLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLA 1424
Query: 1398 CMVQ---PPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFY 1454
CM P P T T CG+ + A+ YF SFY++ A++++NL VA+I++NF Y
Sbjct: 1425 CMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFD--Y 1481
Query: 1455 STEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEV-DLDKDKLLFK 1513
T + +L + L F+ IW D + +G I V LLR ++ L L ++ K
Sbjct: 1482 LTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACK 1541
Query: 1514 HMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEE 1565
+ L++ G V F+ L L ++ I+ LE+ A E+L I++
Sbjct: 1542 RLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQ--ANEELRAIIKK 1591
Score = 145 bits (365), Expect = 4e-34
Identities = 147/687 (21%), Positives = 296/687 (43%), Gaps = 102/687 (14%)
Query: 74 LDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIV 133
++ L + ++T E K+ G++ ++Y+++ W + D +V V L + E A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVV---VGLFSAILEQATKA 218
Query: 134 DQMSPWGMLRIPRPLIMIRAFRIYFRFEL----PRTRIT-NILKRSGEQIWSVSIFLLFF 188
D + G + +RAFR+ L P ++ N + ++ + +++ +LF
Sbjct: 219 DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 278
Query: 189 LLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDL 248
+++Y I+G+++F + N +V P C+ E G QC G C
Sbjct: 279 IIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSP---CALETGHGRQCQNGTVCKP- 334
Query: 249 EDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFF 308
G + G + F+ ++ TV++ + EGW ++Y D+ + YF++L+ F
Sbjct: 335 ---GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIF 391
Query: 309 LAWLVKNVFIAVIIETF------AEIRVQFQQM---------------WGSRS------- 340
++ V N+ + V+ F A+ R FQ++ W +++
Sbjct: 392 GSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPEN 451
Query: 341 -------------STTSTATTQMFHEDAAGG-------WQLVAVDVNKPQGRA------P 374
S ++ T + E+ AGG +A ++K +
Sbjct: 452 EDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNR 511
Query: 375 ACLQKM---MRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDL 431
C +K ++S+VF+ ++ +V ++ + AS +Y N+ + + A A LF
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD--TANKALLALFTA 569
Query: 432 EALLKIWCLGFTGYISSSLHKFELLLVIGTTLH-------VYPDLYHSQFTYFQVLRVVR 484
E LLK++ LG Y S ++F+ +V G L + L S ++LR+ +
Sbjct: 570 EMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFK 629
Query: 485 LIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR-------F 537
+ + +L + V + + + SL++ +I+ S + +Q+F D F
Sbjct: 630 ITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTF 689
Query: 538 TTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP--VVAIYFILYHLFATLILLSLFV 595
FP++ +++FQILT E W VM + A G P +V IYFI+ + ILL++F+
Sbjct: 690 DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFL 749
Query: 596 AVILDNLELDEDLKKLKQLKQSE---------ANADTKEKLPLRLRIFEKFPNRPQMVKI 646
A+ +DNL E L ++ ++ E A+ + K++L + + E ++ + +++
Sbjct: 750 AIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE---SKEEKIEL 806
Query: 647 SKLPSDFTVPKIRESFMKQFIDRQQQD 673
+ +D P + M + +D
Sbjct: 807 KSITADGESPPATKINMDDLQPNENED 833
Score = 103 bits (256), Expect = 2e-21
Identities = 93/357 (26%), Positives = 164/357 (45%), Gaps = 62/357 (17%)
Query: 885 VTYLDW----VMIIVTI-CSCISMMFESPFRRVMHAPT---LQIAEYVFVIFMSIELNLK 936
++ ++W ++I++TI +C+++ PF T L+ EY+F+I ++E LK
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 937 IMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQL-----------L 985
++A GL F P A +R+ ++D I +V L F + Q A+ L L
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGL-FSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 986 MVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAK 1045
R LRPLR+ VP ++ V+ + + +++L+L +++++A G++LF GK+ K
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 1046 C-------------NDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWAN 1092
+DP+ E +G N +V K PG W
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCK-------PG-----------WDG 338
Query: 1093 PRN--FNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVG-PIHGIYIHVFVFLGCMIGLT 1149
P++ NFDN AML +F+ ++++GW +V + +G + +Y V G L
Sbjct: 339 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLN 398
Query: 1150 LFVGVVIANFNENKGTALLTVD-------QRRWEDLKSRLK-IAQPLHLPPRPDNDG 1198
L +GV+ F++ + A D Q+ EDLK L I Q + P +++G
Sbjct: 399 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEG 455
Score = 95.9 bits (237), Expect = 3e-19
Identities = 127/626 (20%), Positives = 258/626 (41%), Gaps = 97/626 (15%)
Query: 33 INKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHI 92
+N +L+ ++S IS+ P+ +H ++ D + ++T E+I KM
Sbjct: 897 VNDTIFTNLILFFILLSSISLAAEDPV--QHTSFRNHILGNADYVFTSIFTLEIILKMTA 954
Query: 93 RGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIR 152
G S+ ++ + + D L VS+ L F I Q S +++I R L ++R
Sbjct: 955 YGAFLHKGSFCRNYFNILD-----LLVVSVSLISFGI-----QSSAINVVKILRVLRVLR 1004
Query: 153 AFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDT 212
R R + + + + + I ++ I ++ +GVQ+F Y C + +
Sbjct: 1005 PLRAINRAKGLK-HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS-DSS 1062
Query: 213 KPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFT 272
K I T+ E++ P ++ + F+ + ++
Sbjct: 1063 KQTEAECKGNYI--TYKDGEVDHPIIQPRSWENSKFD-------------FDNVLAAMMA 1107
Query: 273 VYEAASQEGWVFLMYRAIDSFPRWRSYFY---------FITLIFFLAWLVKNVFIAVIIE 323
++ ++ EGW L+YR+IDS + Y FI I +A+ + N+F+ +I
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 324 TFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPACLQKMMRS 383
TF E Q +Q + + + + A + + P+ + + ++ S
Sbjct: 1168 TFQE---QGEQEYKNCELDKNQRQCVEYALKARPLRRYI------PKNQHQYKVWYVVNS 1218
Query: 384 SVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFT 443
+ F + ++ ++ I A +Y G++ + + + FT LF +E +LK+
Sbjct: 1219 TYFEYLMFVLILLNTICLAMQHY-GQSCLFKI-AMNILNMLFTGLFTVEMILKLIAFKPK 1276
Query: 444 GYISSSLHKFELLLVIGTTLHV----YPDLYHSQ--------------FTYFQVLRVVRL 485
Y + + F+ L+V+G+ + + H+Q T+F++ RV+RL
Sbjct: 1277 HYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRL 1336
Query: 486 IKI---SPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVE-----ELDR- 536
+K+ + ++ + L + + L + + I +Q+F + E++R
Sbjct: 1337 VKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRN 1396
Query: 537 --FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP-----------------VVAI 577
F TFP+A + +F+ T E W D+M + G AP
Sbjct: 1397 NNFQTFPQAVLLLFRCATGEAWQDIMLACMP--GKKCAPESEPSNSTEGETPCGSSFAVF 1454
Query: 578 YFILYHLFATLILLSLFVAVILDNLE 603
YFI +++ ++++LFVAVI+DN +
Sbjct: 1455 YFISFYMLCAFLIINLFVAVIMDNFD 1480
Score = 78.2 bits (191), Expect = 7e-14
Identities = 57/250 (22%), Positives = 122/250 (48%), Gaps = 17/250 (6%)
Query: 1206 ITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSP 1265
+ + F+ I L+ L + S ++ + +T T + +F E+ +K+ ++
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1266 AGFWQSRRNRYDLLVTSLGVVWVVL-HFALLNAYTYMMGACVIVFRFFSICGKHVTLKML 1324
++ S NR+D V G++ +L +++ + CV + R F I +L L
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1325 LLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFG-TVKYGENINRHANFSSAGKAITVLF 1383
+ +++ S+ +++ +FL ++ ++ G+ LFG + E R + F + +++ +F
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVF 700
Query: 1384 RIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGAL--MYFCSFYVIIAYIMLNL 1441
+I+TGEDWN +M+D ++ A ++ G L +YF ++ YI+LN+
Sbjct: 701 QILTGEDWNSVMYDGIM-------------AYGGPSFPGMLVCIYFIILFICGNYILLNV 747
Query: 1442 LVAIIVENFS 1451
+AI V+N +
Sbjct: 748 FLAIAVDNLA 757
Score = 58.9 bits (141), Expect = 4e-08
Identities = 68/287 (23%), Positives = 120/287 (41%), Gaps = 68/287 (23%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDTL---LMFLYTAEMIAKMHIRGIVKGDSSYVKD 105
+ V +NT + EHY ++T DT L+ L+TAEM+ KM+ G+ +Y
Sbjct: 531 IFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL----QAYFVS 586
Query: 106 RWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRT 165
+ FD F+V + +L +I MSP G + + R + ++R F+I R+ +
Sbjct: 587 LFNRFDCFVVCGGILETILVETKI------MSPLG-ISVLRCVRLLRIFKIT-RYWNSLS 638
Query: 166 RITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIP 225
+ L S I S+ + L F++++ +LG+Q+FG G ++ +
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFG-------------GKFNFDEM--- 682
Query: 226 DTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFL 285
+ S F+ S+ TV++ + E W +
Sbjct: 683 -------------------------------QTRRSTFDNFPQSLLTVFQILTGEDWNSV 711
Query: 286 MYRAI-----DSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAE 327
MY I SFP YFI L +++ NVF+A+ ++ A+
Sbjct: 712 MYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLAD 758
Score = 51.2 bits (121), Expect = 9e-06
Identities = 64/306 (20%), Positives = 120/306 (39%), Gaps = 62/306 (20%)
Query: 890 WVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
W++I + + +++ E + A + + E+ LK+ + GL ++
Sbjct: 528 WLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSL 587
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVP---QMRKV 1006
F D F+ ++ + + + G + VLRC+R LRIFK+ + +
Sbjct: 588 FNRF----DCFVVCGGILETILVETKIMSPLG---ISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1007 VRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVS 1066
V L + + I + +LL +++F+ G+QLF GK F +
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGK------------------FNFDE- 681
Query: 1067 VSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVR-DVII 1125
R FDN ++L +F++L+ + W V D I+
Sbjct: 682 ------------------------MQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIM 717
Query: 1126 HRVGP-----IHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKS 1180
GP + IY + G I L +F+ + + N + + LT Q+ E+ K
Sbjct: 718 AYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAES---LTSAQKEEEEEKE 774
Query: 1181 RLKIAQ 1186
R K+A+
Sbjct: 775 RKKLAR 780
Score = 48.9 bits (115), Expect = 4e-05
Identities = 57/275 (20%), Positives = 117/275 (42%), Gaps = 57/275 (20%)
Query: 379 KMMRSSVFHMFILSMVTVDVI-VAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKI 437
+++ ++F IL + + I +AA + + +FR A+ FT +F LE +LK+
Sbjct: 895 RIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHI--LGNADYVFTSIFTLEIILKM 952
Query: 438 WCLG---FTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFTYFQVLRVVRL------IKI 488
G G + LLV+ +L + + S ++LRV+R+ I
Sbjct: 953 TAYGAFLHKGSFCRNYFNILDLLVVSVSLISF-GIQSSAINVVKILRVLRVLRPLRAINR 1011
Query: 489 SPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF------CFVE---------- 532
+ L+ V +F + +G++V+ T L + + I +Q+F C
Sbjct: 1012 AKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKG 1071
Query: 533 --------ELDRFTTFPR--------------AFMSMFQILTQEGWVDVMDQTLNAVGHM 570
E+D PR A M++F + T EGW +++ +++++
Sbjct: 1072 NYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTED 1131
Query: 571 WAPV------VAIYFILYHLFATLILLSLFVAVIL 599
P+ ++I+FI+Y + ++++FV ++
Sbjct: 1132 KGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
Score = 43.5 bits (101), Expect = 0.002
Identities = 58/300 (19%), Positives = 110/300 (36%), Gaps = 76/300 (25%)
Query: 1212 FKRTIALLVLAQSVLLSV----KWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMS--- 1264
F+ I L + A V L++ D + L + +F IF +E +K+IA
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLF 185
Query: 1265 -PAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGA-----------CVIVFRFF 1312
P + ++ N D ++ +G+ +L A +G V R
Sbjct: 186 HPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPL 245
Query: 1313 SICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLF--------------- 1357
+ +L+++L +++ +M I + + +++ YA G+ LF
Sbjct: 246 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIA 305
Query: 1358 -----------------------GTV-KYGENINRHA--NFSSAGKAITVLFRIVTGEDW 1391
GTV K G + +H NF + A+ +F+ +T E W
Sbjct: 306 DVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGW 365
Query: 1392 NKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFS 1451
++ YW D Y +YF S + ++ +LNL++ ++ FS
Sbjct: 366 TDVL----------------YWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFS 409
>gi|193794828 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 7 [Homo sapiens]
Length = 2157
Score = 218 bits (556), Expect = 3e-56
Identities = 194/737 (26%), Positives = 342/737 (46%), Gaps = 64/737 (8%)
Query: 891 VMIIVTICSCISMMFESPFRRV-MHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
+++ + S IS+ E P + L + VF +IE+ LK+ A G F +
Sbjct: 905 LILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSF 964
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRE 1009
R++ ++D+ + VSLI + ++L VLR LRPLR ++ VV+
Sbjct: 965 CRNYFNILDLLVVSVSLISFGIQSSAINV---VKILRVLRVLRPLRAINRAKGLKHVVQC 1021
Query: 1010 LFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSK 1069
+F + I + I+ L +FA GVQLF GKL C+D + +C G +
Sbjct: 1022 VFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNY-------- 1073
Query: 1070 NLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEV--RDVIIHR 1127
+ + GE PR W N + F+FDNV AM+ALF V + +GW E+ R + H
Sbjct: 1074 ---ITYKDGEVDHPIIQPRSWENSK-FDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHT 1129
Query: 1128 --VGPIH------GIYIHVFVFLGCMIGLTLFVGVVIANFNE--NKGTALLTVDQRRWED 1177
GPI+ I+ +++ + + +FVG VI F E + +D+ + +
Sbjct: 1130 EDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQC 1189
Query: 1178 LKSRLKIAQPL--HLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVK-WDVE 1234
++ LK A+PL ++P + + K++ + +F+ + +L+L ++ L+++ +
Sbjct: 1190 VEYALK-ARPLRRYIP----KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQS 1244
Query: 1235 DPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFAL 1294
+ + ++++FT +F +E+ +K+IA P G++ N +D L+ ++ V+L
Sbjct: 1245 CLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETN 1304
Query: 1295 LNAYTYMMGA---------CVIVFRFF------SICGKHVTLKMLLLTVVVSMYKSFFII 1339
+T + + FR F + + ++ LL T + S ++
Sbjct: 1305 PAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVA 1364
Query: 1340 VGMFLLLLCYAFAGVVLFGTVKYGE--NINRHANFSSAGKAITVLFRIVTGEDWNKIMHD 1397
+ + +L YA G+ +FG + + INR+ NF + +A+ +LFR TGE W IM
Sbjct: 1365 LLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLA 1424
Query: 1398 CMVQ---PPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFY 1454
CM P P T T CG+ + A+ YF SFY++ A++++NL VA+I++NF Y
Sbjct: 1425 CMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFD--Y 1481
Query: 1455 STEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEV-DLDKDKLLFK 1513
T + +L + L F+ IW D + +G I V LLR ++ L L ++ K
Sbjct: 1482 LTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACK 1541
Query: 1514 HMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEE----EVAK 1569
+ L++ G V F+ L L ++ I+ A + E E A
Sbjct: 1542 RLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQAN 1601
Query: 1570 QTIRMWLKKCLKRIRAK 1586
+ +R +KK KR K
Sbjct: 1602 EELRAIIKKIWKRTSMK 1618
Score = 147 bits (370), Expect = 1e-34
Identities = 149/687 (21%), Positives = 296/687 (43%), Gaps = 102/687 (14%)
Query: 74 LDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIV 133
++ L + ++T E K+ G++ ++Y+++ W + D +V V L + E A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVV---VGLFSAILEQATKA 218
Query: 134 DQMSPWGMLRIPRPLIMIRAFRIYFRFEL----PRTRIT-NILKRSGEQIWSVSIFLLFF 188
D + G + +RAFR+ L P ++ N + ++ + +++ +LF
Sbjct: 219 DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 278
Query: 189 LLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDL 248
+++Y I+G+++F + N +V P C+ E G QC G C
Sbjct: 279 IIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSP---CALETGHGRQCQNGTVCKP- 334
Query: 249 EDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFF 308
G + G + F+ ++ TV++ + EGW ++Y D+ R + YF+TLI
Sbjct: 335 ---GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIII 391
Query: 309 LAWLVKNVFIAVIIETF------AEIRVQFQQM---------------WGSRS------- 340
++ V N+ + V+ F A+ R FQ++ W +++
Sbjct: 392 GSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPEN 451
Query: 341 -------------STTSTATTQMFHEDAAGG-------WQLVAVDVNKPQGRA------P 374
S ++ T + E+ AGG +A ++K +
Sbjct: 452 EDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNR 511
Query: 375 ACLQKM---MRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDL 431
C +K ++S+VF+ ++ +V ++ + AS +Y N+ + + A A LF
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD--TANKALLALFTA 569
Query: 432 EALLKIWCLGFTGYISSSLHKFELLLVIGTTLH-------VYPDLYHSQFTYFQVLRVVR 484
E LLK++ LG Y S ++F+ +V G L + L S ++LR+ +
Sbjct: 570 EMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFK 629
Query: 485 LIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR-------F 537
+ + +L + V + + + SL++ +I+ S + +Q+F D F
Sbjct: 630 ITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTF 689
Query: 538 TTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP--VVAIYFILYHLFATLILLSLFV 595
FP++ +++FQILT E W VM + A G P +V IYFI+ + ILL++F+
Sbjct: 690 DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFL 749
Query: 596 AVILDNLELDEDLKKLKQLKQSE---------ANADTKEKLPLRLRIFEKFPNRPQMVKI 646
A+ +DNL E L ++ ++ E A+ + K++L + + E ++ + +++
Sbjct: 750 AIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE---SKEEKIEL 806
Query: 647 SKLPSDFTVPKIRESFMKQFIDRQQQD 673
+ +D P + M + +D
Sbjct: 807 KSITADGESPPATKINMDDLQPNENED 833
Score = 104 bits (260), Expect = 7e-22
Identities = 94/357 (26%), Positives = 164/357 (45%), Gaps = 62/357 (17%)
Query: 885 VTYLDW----VMIIVTI-CSCISMMFESPFRRVMHAPT---LQIAEYVFVIFMSIELNLK 936
++ ++W ++I++TI +C+++ PF T L+ EY+F+I ++E LK
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 937 IMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQL-----------L 985
++A GL F P A +R+ ++D I +V L F + Q A+ L L
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGL-FSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 986 MVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAK 1045
R LRPLR+ VP ++ V+ + + +++L+L +++++A G++LF GK+ K
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 1046 C-------------NDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWAN 1092
+DP+ E +G N +V K PG W
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCK-------PG-----------WDG 338
Query: 1093 PRN--FNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVG-PIHGIYIHVFVFLGCMIGLT 1149
P++ NFDN AML +F+ ++++GW +V + VG IY + +G L
Sbjct: 339 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLN 398
Query: 1150 LFVGVVIANFNENKGTALLTVD-------QRRWEDLKSRLK-IAQPLHLPPRPDNDG 1198
L +GV+ F++ + A D Q+ EDLK L I Q + P +++G
Sbjct: 399 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEG 455
Score = 102 bits (255), Expect = 2e-21
Identities = 131/626 (20%), Positives = 259/626 (41%), Gaps = 97/626 (15%)
Query: 33 INKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHI 92
+N +L+ ++S IS+ P+ +H ++ F D + ++T E+ KM
Sbjct: 897 VNDTIFTNLILFFILLSSISLAAEDPV--QHTSFRNHILFYFDIVFTTIFTIEIALKMTA 954
Query: 93 RGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIR 152
G S+ ++ + + D L VS+ L F I Q S +++I R L ++R
Sbjct: 955 YGAFLHKGSFCRNYFNILD-----LLVVSVSLISFGI-----QSSAINVVKILRVLRVLR 1004
Query: 153 AFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDT 212
R R + + + + + I ++ I ++ +GVQ+F Y C + +
Sbjct: 1005 PLRAINRAKGLK-HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS-DSS 1062
Query: 213 KPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFT 272
K I T+ E++ P ++ + F+ + ++
Sbjct: 1063 KQTEAECKGNYI--TYKDGEVDHPIIQPRSWENSKFD-------------FDNVLAAMMA 1107
Query: 273 VYEAASQEGWVFLMYRAIDSFPRWRSYFY---------FITLIFFLAWLVKNVFIAVIIE 323
++ ++ EGW L+YR+IDS + Y FI I +A+ + N+F+ +I
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 324 TFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPACLQKMMRS 383
TF E Q +Q + + + + A + + P+ + + ++ S
Sbjct: 1168 TFQE---QGEQEYKNCELDKNQRQCVEYALKARPLRRYI------PKNQHQYKVWYVVNS 1218
Query: 384 SVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFT 443
+ F + ++ ++ I A +Y G++ + + + FT LF +E +LK+
Sbjct: 1219 TYFEYLMFVLILLNTICLAMQHY-GQSCLFKI-AMNILNMLFTGLFTVEMILKLIAFKPK 1276
Query: 444 GYISSSLHKFELLLVIGTTLHVY----PDLYHSQ--------------FTYFQVLRVVRL 485
GY S + F+ L+VIG+ + V H+Q T+F++ RV+RL
Sbjct: 1277 GYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRL 1336
Query: 486 IKI---SPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFV-----EELDR- 536
+K+ + ++ + L + + L + + I +Q+F + E++R
Sbjct: 1337 VKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRN 1396
Query: 537 --FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP-----------------VVAI 577
F TFP+A + +F+ T E W D+M + G AP
Sbjct: 1397 NNFQTFPQAVLLLFRCATGEAWQDIMLACM--PGKKCAPESEPSNSTEGETPCGSSFAVF 1454
Query: 578 YFILYHLFATLILLSLFVAVILDNLE 603
YFI +++ ++++LFVAVI+DN +
Sbjct: 1455 YFISFYMLCAFLIINLFVAVIMDNFD 1480
Score = 78.2 bits (191), Expect = 7e-14
Identities = 57/250 (22%), Positives = 122/250 (48%), Gaps = 17/250 (6%)
Query: 1206 ITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSP 1265
+ + F+ I L+ L + S ++ + +T T + +F E+ +K+ ++
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1266 AGFWQSRRNRYDLLVTSLGVVWVVL-HFALLNAYTYMMGACVIVFRFFSICGKHVTLKML 1324
++ S NR+D V G++ +L +++ + CV + R F I +L L
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1325 LLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFG-TVKYGENINRHANFSSAGKAITVLF 1383
+ +++ S+ +++ +FL ++ ++ G+ LFG + E R + F + +++ +F
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVF 700
Query: 1384 RIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGAL--MYFCSFYVIIAYIMLNL 1441
+I+TGEDWN +M+D ++ A ++ G L +YF ++ YI+LN+
Sbjct: 701 QILTGEDWNSVMYDGIM-------------AYGGPSFPGMLVCIYFIILFICGNYILLNV 747
Query: 1442 LVAIIVENFS 1451
+AI V+N +
Sbjct: 748 FLAIAVDNLA 757
Score = 58.9 bits (141), Expect = 4e-08
Identities = 68/287 (23%), Positives = 120/287 (41%), Gaps = 68/287 (23%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDTL---LMFLYTAEMIAKMHIRGIVKGDSSYVKD 105
+ V +NT + EHY ++T DT L+ L+TAEM+ KM+ G+ +Y
Sbjct: 531 IFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL----QAYFVS 586
Query: 106 RWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRT 165
+ FD F+V + +L +I MSP G + + R + ++R F+I R+ +
Sbjct: 587 LFNRFDCFVVCGGILETILVETKI------MSPLG-ISVLRCVRLLRIFKIT-RYWNSLS 638
Query: 166 RITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIP 225
+ L S I S+ + L F++++ +LG+Q+FG G ++ +
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFG-------------GKFNFDEM--- 682
Query: 226 DTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFL 285
+ S F+ S+ TV++ + E W +
Sbjct: 683 -------------------------------QTRRSTFDNFPQSLLTVFQILTGEDWNSV 711
Query: 286 MYRAI-----DSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAE 327
MY I SFP YFI L +++ NVF+A+ ++ A+
Sbjct: 712 MYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLAD 758
Score = 51.2 bits (121), Expect = 9e-06
Identities = 64/306 (20%), Positives = 120/306 (39%), Gaps = 62/306 (20%)
Query: 890 WVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
W++I + + +++ E + A + + E+ LK+ + GL ++
Sbjct: 528 WLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSL 587
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVP---QMRKV 1006
F D F+ ++ + + + G + VLRC+R LRIFK+ + +
Sbjct: 588 FNRF----DCFVVCGGILETILVETKIMSPLG---ISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1007 VRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVS 1066
V L + + I + +LL +++F+ G+QLF GK F +
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGK------------------FNFDE- 681
Query: 1067 VSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVR-DVII 1125
R FDN ++L +F++L+ + W V D I+
Sbjct: 682 ------------------------MQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIM 717
Query: 1126 HRVGP-----IHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKS 1180
GP + IY + G I L +F+ + + N + + LT Q+ E+ K
Sbjct: 718 AYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAES---LTSAQKEEEEEKE 774
Query: 1181 RLKIAQ 1186
R K+A+
Sbjct: 775 RKKLAR 780
Score = 41.6 bits (96), Expect = 0.007
Identities = 57/300 (19%), Positives = 110/300 (36%), Gaps = 76/300 (25%)
Query: 1212 FKRTIALLVLAQSVLLSV----KWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMS--- 1264
F+ I L + A V L++ D + L + +F IF +E +K+IA
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLF 185
Query: 1265 -PAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGA-----------CVIVFRFF 1312
P + ++ N D ++ +G+ +L A +G V R
Sbjct: 186 HPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPL 245
Query: 1313 SICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLF--------------- 1357
+ +L+++L +++ +M I + + +++ YA G+ LF
Sbjct: 246 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIA 305
Query: 1358 -----------------------GTV-KYGENINRHA--NFSSAGKAITVLFRIVTGEDW 1391
GTV K G + +H NF + A+ +F+ +T E W
Sbjct: 306 DVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGW 365
Query: 1392 NKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFS 1451
++ YW D +YF + +I ++ +LNL++ ++ FS
Sbjct: 366 TDVL----------------YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS 409
>gi|193794832 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoforom 13 [Homo sapiens]
Length = 2144
Score = 218 bits (554), Expect = 5e-56
Identities = 193/728 (26%), Positives = 339/728 (46%), Gaps = 59/728 (8%)
Query: 891 VMIIVTICSCISMMFESPFRRV-MHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
+++ + S IS+ E P + L + VF +IE+ LK+ A G F +
Sbjct: 905 LILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSF 964
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRE 1009
R++ ++D+ + VSLI + ++L VLR LRPLR ++ VV+
Sbjct: 965 CRNYFNILDLLVVSVSLISFGIQSSAINV---VKILRVLRVLRPLRAINRAKGLKHVVQC 1021
Query: 1010 LFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSK 1069
+F + I + I+ L +FA GVQLF GKL C+D + +C G +
Sbjct: 1022 VFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNY-------- 1073
Query: 1070 NLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEV--RDVIIHR 1127
+ + GE PR W N + F+FDNV AM+ALF V + +GW E+ R + H
Sbjct: 1074 ---ITYKDGEVDHPIIQPRSWENSK-FDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHT 1129
Query: 1128 --VGPIH------GIYIHVFVFLGCMIGLTLFVGVVIANFNE--NKGTALLTVDQRRWED 1177
GPI+ I+ +++ + + +FVG VI F E + +D+ + +
Sbjct: 1130 EDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQC 1189
Query: 1178 LKSRLKIAQPL--HLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVK-WDVE 1234
++ LK A+PL ++P + + K++ + +F+ + +L+L ++ L+++ +
Sbjct: 1190 VEYALK-ARPLRRYIP----KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQS 1244
Query: 1235 DPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFAL 1294
+ + ++++FT +F +E+ +K+IA P ++ N +D L+ VV ++ A+
Sbjct: 1245 CLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALI----VVGSIVDIAI 1300
Query: 1295 LNAYTYMMGACVIVFRFF------SICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLC 1348
+ FR F + + ++ LL T + S ++ + + +L
Sbjct: 1301 TENAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFI 1360
Query: 1349 YAFAGVVLFGTVKYGE--NINRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQ---PP 1403
YA G+ +FG + + INR+ NF + +A+ +LFR TGE W IM CM P
Sbjct: 1361 YAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAP 1420
Query: 1404 FCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLS 1463
P T T CG+ + A+ YF SFY++ A++++NL VA+I++NF Y T + +L
Sbjct: 1421 ESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFD--YLTRDWSILG 1477
Query: 1464 YNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEV-DLDKDKLLFKHMCYEMERL 1522
+ L F+ IW D + +G I V LLR ++ L L ++ K + L
Sbjct: 1478 PHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPL 1537
Query: 1523 HNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEE----EVAKQTIRMWLKK 1578
++ G V F+ L L ++ I+ A + E E A + +R +KK
Sbjct: 1538 NSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKK 1597
Query: 1579 CLKRIRAK 1586
KR K
Sbjct: 1598 IWKRTSMK 1605
Score = 147 bits (370), Expect = 1e-34
Identities = 149/687 (21%), Positives = 296/687 (43%), Gaps = 102/687 (14%)
Query: 74 LDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIV 133
++ L + ++T E K+ G++ ++Y+++ W + D +V V L + E A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVV---VGLFSAILEQATKA 218
Query: 134 DQMSPWGMLRIPRPLIMIRAFRIYFRFEL----PRTRIT-NILKRSGEQIWSVSIFLLFF 188
D + G + +RAFR+ L P ++ N + ++ + +++ +LF
Sbjct: 219 DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 278
Query: 189 LLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDL 248
+++Y I+G+++F + N +V P C+ E G QC G C
Sbjct: 279 IIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSP---CALETGHGRQCQNGTVCKP- 334
Query: 249 EDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFF 308
G + G + F+ ++ TV++ + EGW ++Y D+ R + YF+TLI
Sbjct: 335 ---GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIII 391
Query: 309 LAWLVKNVFIAVIIETF------AEIRVQFQQM---------------WGSRS------- 340
++ V N+ + V+ F A+ R FQ++ W +++
Sbjct: 392 GSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPEN 451
Query: 341 -------------STTSTATTQMFHEDAAGG-------WQLVAVDVNKPQGRA------P 374
S ++ T + E+ AGG +A ++K +
Sbjct: 452 EDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNR 511
Query: 375 ACLQKM---MRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDL 431
C +K ++S+VF+ ++ +V ++ + AS +Y N+ + + A A LF
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD--TANKALLALFTA 569
Query: 432 EALLKIWCLGFTGYISSSLHKFELLLVIGTTLH-------VYPDLYHSQFTYFQVLRVVR 484
E LLK++ LG Y S ++F+ +V G L + L S ++LR+ +
Sbjct: 570 EMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFK 629
Query: 485 LIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR-------F 537
+ + +L + V + + + SL++ +I+ S + +Q+F D F
Sbjct: 630 ITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTF 689
Query: 538 TTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP--VVAIYFILYHLFATLILLSLFV 595
FP++ +++FQILT E W VM + A G P +V IYFI+ + ILL++F+
Sbjct: 690 DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFL 749
Query: 596 AVILDNLELDEDLKKLKQLKQSE---------ANADTKEKLPLRLRIFEKFPNRPQMVKI 646
A+ +DNL E L ++ ++ E A+ + K++L + + E ++ + +++
Sbjct: 750 AIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE---SKEEKIEL 806
Query: 647 SKLPSDFTVPKIRESFMKQFIDRQQQD 673
+ +D P + M + +D
Sbjct: 807 KSITADGESPPATKINMDDLQPNENED 833
Score = 104 bits (260), Expect = 7e-22
Identities = 94/357 (26%), Positives = 164/357 (45%), Gaps = 62/357 (17%)
Query: 885 VTYLDW----VMIIVTI-CSCISMMFESPFRRVMHAPT---LQIAEYVFVIFMSIELNLK 936
++ ++W ++I++TI +C+++ PF T L+ EY+F+I ++E LK
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 937 IMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQL-----------L 985
++A GL F P A +R+ ++D I +V L F + Q A+ L L
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGL-FSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 986 MVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAK 1045
R LRPLR+ VP ++ V+ + + +++L+L +++++A G++LF GK+ K
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 1046 C-------------NDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWAN 1092
+DP+ E +G N +V K PG W
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCK-------PG-----------WDG 338
Query: 1093 PRN--FNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVG-PIHGIYIHVFVFLGCMIGLT 1149
P++ NFDN AML +F+ ++++GW +V + VG IY + +G L
Sbjct: 339 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLN 398
Query: 1150 LFVGVVIANFNENKGTALLTVD-------QRRWEDLKSRLK-IAQPLHLPPRPDNDG 1198
L +GV+ F++ + A D Q+ EDLK L I Q + P +++G
Sbjct: 399 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEG 455
Score = 100 bits (250), Expect = 9e-21
Identities = 125/613 (20%), Positives = 256/613 (41%), Gaps = 84/613 (13%)
Query: 33 INKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHI 92
+N +L+ ++S IS+ P+ +H ++ F D + ++T E+ KM
Sbjct: 897 VNDTIFTNLILFFILLSSISLAAEDPV--QHTSFRNHILFYFDIVFTTIFTIEIALKMTA 954
Query: 93 RGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIR 152
G S+ ++ + + D L VS+ L F I Q S +++I R L ++R
Sbjct: 955 YGAFLHKGSFCRNYFNILD-----LLVVSVSLISFGI-----QSSAINVVKILRVLRVLR 1004
Query: 153 AFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDT 212
R R + + + + + I ++ I ++ +GVQ+F Y C + +
Sbjct: 1005 PLRAINRAKGLK-HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS-DSS 1062
Query: 213 KPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFT 272
K I T+ E++ P ++ + F+ + ++
Sbjct: 1063 KQTEAECKGNYI--TYKDGEVDHPIIQPRSWENSKFD-------------FDNVLAAMMA 1107
Query: 273 VYEAASQEGWVFLMYRAIDSFPRWRSYFY---------FITLIFFLAWLVKNVFIAVIIE 323
++ ++ EGW L+YR+IDS + Y FI I +A+ + N+F+ +I
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 324 TFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPACLQKMMRS 383
TF E Q +Q + + + + A + + P+ + + ++ S
Sbjct: 1168 TFQE---QGEQEYKNCELDKNQRQCVEYALKARPLRRYI------PKNQHQYKVWYVVNS 1218
Query: 384 SVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFT 443
+ F + ++ ++ I A +Y G++ + + + FT LF +E +LK+
Sbjct: 1219 TYFEYLMFVLILLNTICLAMQHY-GQSCLFKI-AMNILNMLFTGLFTVEMILKLIAFKPK 1276
Query: 444 GYISSSLHKFELLLVIGTTLHVY-----PDLYHSQFTYFQVLRVVRLIKI---SPALEDF 495
Y + + F+ L+V+G+ + + + T+F++ RV+RL+K+ +
Sbjct: 1277 HYFCDAWNTFDALIVVGSIVDIAITENAEENSRISITFFRLFRVMRLVKLLSRGEGIRTL 1336
Query: 496 VYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVE-----ELDR---FTTFPRAFMSM 547
++ + L + + L + + I +Q+F + E++R F TFP+A + +
Sbjct: 1337 LWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLL 1396
Query: 548 FQILTQEGWVDVMDQTLNAVGHMWAP-----------------VVAIYFILYHLFATLIL 590
F+ T E W D+M + G AP YFI +++ ++
Sbjct: 1397 FRCATGEAWQDIMLACMP--GKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLI 1454
Query: 591 LSLFVAVILDNLE 603
++LFVAVI+DN +
Sbjct: 1455 INLFVAVIMDNFD 1467
Score = 78.2 bits (191), Expect = 7e-14
Identities = 57/250 (22%), Positives = 122/250 (48%), Gaps = 17/250 (6%)
Query: 1206 ITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSP 1265
+ + F+ I L+ L + S ++ + +T T + +F E+ +K+ ++
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1266 AGFWQSRRNRYDLLVTSLGVVWVVL-HFALLNAYTYMMGACVIVFRFFSICGKHVTLKML 1324
++ S NR+D V G++ +L +++ + CV + R F I +L L
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1325 LLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFG-TVKYGENINRHANFSSAGKAITVLF 1383
+ +++ S+ +++ +FL ++ ++ G+ LFG + E R + F + +++ +F
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVF 700
Query: 1384 RIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGAL--MYFCSFYVIIAYIMLNL 1441
+I+TGEDWN +M+D ++ A ++ G L +YF ++ YI+LN+
Sbjct: 701 QILTGEDWNSVMYDGIM-------------AYGGPSFPGMLVCIYFIILFICGNYILLNV 747
Query: 1442 LVAIIVENFS 1451
+AI V+N +
Sbjct: 748 FLAIAVDNLA 757
Score = 58.9 bits (141), Expect = 4e-08
Identities = 68/287 (23%), Positives = 120/287 (41%), Gaps = 68/287 (23%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDTL---LMFLYTAEMIAKMHIRGIVKGDSSYVKD 105
+ V +NT + EHY ++T DT L+ L+TAEM+ KM+ G+ +Y
Sbjct: 531 IFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL----QAYFVS 586
Query: 106 RWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRT 165
+ FD F+V + +L +I MSP G + + R + ++R F+I R+ +
Sbjct: 587 LFNRFDCFVVCGGILETILVETKI------MSPLG-ISVLRCVRLLRIFKIT-RYWNSLS 638
Query: 166 RITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIP 225
+ L S I S+ + L F++++ +LG+Q+FG G ++ +
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFG-------------GKFNFDEM--- 682
Query: 226 DTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFL 285
+ S F+ S+ TV++ + E W +
Sbjct: 683 -------------------------------QTRRSTFDNFPQSLLTVFQILTGEDWNSV 711
Query: 286 MYRAI-----DSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAE 327
MY I SFP YFI L +++ NVF+A+ ++ A+
Sbjct: 712 MYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLAD 758
Score = 51.2 bits (121), Expect = 9e-06
Identities = 64/306 (20%), Positives = 120/306 (39%), Gaps = 62/306 (20%)
Query: 890 WVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
W++I + + +++ E + A + + E+ LK+ + GL ++
Sbjct: 528 WLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSL 587
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVP---QMRKV 1006
F D F+ ++ + + + G + VLRC+R LRIFK+ + +
Sbjct: 588 FNRF----DCFVVCGGILETILVETKIMSPLG---ISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1007 VRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVS 1066
V L + + I + +LL +++F+ G+QLF GK F +
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGK------------------FNFDE- 681
Query: 1067 VSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVR-DVII 1125
R FDN ++L +F++L+ + W V D I+
Sbjct: 682 ------------------------MQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIM 717
Query: 1126 HRVGP-----IHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKS 1180
GP + IY + G I L +F+ + + N + + LT Q+ E+ K
Sbjct: 718 AYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAES---LTSAQKEEEEEKE 774
Query: 1181 RLKIAQ 1186
R K+A+
Sbjct: 775 RKKLAR 780
Score = 41.6 bits (96), Expect = 0.007
Identities = 57/300 (19%), Positives = 110/300 (36%), Gaps = 76/300 (25%)
Query: 1212 FKRTIALLVLAQSVLLSV----KWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMS--- 1264
F+ I L + A V L++ D + L + +F IF +E +K+IA
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLF 185
Query: 1265 -PAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGA-----------CVIVFRFF 1312
P + ++ N D ++ +G+ +L A +G V R
Sbjct: 186 HPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPL 245
Query: 1313 SICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLF--------------- 1357
+ +L+++L +++ +M I + + +++ YA G+ LF
Sbjct: 246 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIA 305
Query: 1358 -----------------------GTV-KYGENINRHA--NFSSAGKAITVLFRIVTGEDW 1391
GTV K G + +H NF + A+ +F+ +T E W
Sbjct: 306 DVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGW 365
Query: 1392 NKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFS 1451
++ YW D +YF + +I ++ +LNL++ ++ FS
Sbjct: 366 TDVL----------------YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS 409
>gi|193788532 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 11 [Homo sapiens]
Length = 2146
Score = 216 bits (550), Expect = 2e-55
Identities = 192/728 (26%), Positives = 339/728 (46%), Gaps = 57/728 (7%)
Query: 891 VMIIVTICSCISMMFESPFRRV-MHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
+++ + S IS+ E P + L + VF +IE+ LK+ A G F +
Sbjct: 905 LILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSF 964
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRE 1009
R++ ++D+ + VSLI + ++L VLR LRPLR ++ VV+
Sbjct: 965 CRNYFNILDLLVVSVSLISFGIQSSAINV---VKILRVLRVLRPLRAINRAKGLKHVVQC 1021
Query: 1010 LFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSK 1069
+F + I + I+ L +FA GVQLF GKL C+D + +C G +
Sbjct: 1022 VFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNY-------- 1073
Query: 1070 NLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEV--RDVIIHR 1127
+ + GE PR W N + F+FDNV AM+ALF V + +GW E+ R + H
Sbjct: 1074 ---ITYKDGEVDHPIIQPRSWENSK-FDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHT 1129
Query: 1128 --VGPIH------GIYIHVFVFLGCMIGLTLFVGVVIANFNE--NKGTALLTVDQRRWED 1177
GPI+ I+ +++ + + +FVG VI F E + +D+ + +
Sbjct: 1130 EDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQC 1189
Query: 1178 LKSRLKIAQPL--HLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVK-WDVE 1234
++ LK A+PL ++P + + K++ + +F+ + +L+L ++ L+++ +
Sbjct: 1190 VEYALK-ARPLRRYIP----KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQS 1244
Query: 1235 DPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFAL 1294
+ + ++++FT +F +E+ +K+IA P ++ N +D L+ +V + +
Sbjct: 1245 CLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAI--TE 1302
Query: 1295 LNAYTYMMGACVIVFRFF------SICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLC 1348
+N + FR F + + ++ LL T + S ++ + + +L
Sbjct: 1303 VNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFI 1362
Query: 1349 YAFAGVVLFGTVKYGE--NINRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQ---PP 1403
YA G+ +FG + + INR+ NF + +A+ +LFR TGE W IM CM P
Sbjct: 1363 YAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAP 1422
Query: 1404 FCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLS 1463
P T T CG+ + A+ YF SFY++ A++++NL VA+I++NF Y T + +L
Sbjct: 1423 ESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFD--YLTRDWSILG 1479
Query: 1464 YNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEV-DLDKDKLLFKHMCYEMERL 1522
+ L F+ IW D + +G I V LLR ++ L L ++ K + L
Sbjct: 1480 PHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPL 1539
Query: 1523 HNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEE----EVAKQTIRMWLKK 1578
++ G V F+ L L ++ I+ A + E E A + +R +KK
Sbjct: 1540 NSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKK 1599
Query: 1579 CLKRIRAK 1586
KR K
Sbjct: 1600 IWKRTSMK 1607
Score = 147 bits (370), Expect = 1e-34
Identities = 149/687 (21%), Positives = 296/687 (43%), Gaps = 102/687 (14%)
Query: 74 LDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIV 133
++ L + ++T E K+ G++ ++Y+++ W + D +V V L + E A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVV---VGLFSAILEQATKA 218
Query: 134 DQMSPWGMLRIPRPLIMIRAFRIYFRFEL----PRTRIT-NILKRSGEQIWSVSIFLLFF 188
D + G + +RAFR+ L P ++ N + ++ + +++ +LF
Sbjct: 219 DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 278
Query: 189 LLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDL 248
+++Y I+G+++F + N +V P C+ E G QC G C
Sbjct: 279 IIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSP---CALETGHGRQCQNGTVCKP- 334
Query: 249 EDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFF 308
G + G + F+ ++ TV++ + EGW ++Y D+ R + YF+TLI
Sbjct: 335 ---GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIII 391
Query: 309 LAWLVKNVFIAVIIETF------AEIRVQFQQM---------------WGSRS------- 340
++ V N+ + V+ F A+ R FQ++ W +++
Sbjct: 392 GSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPEN 451
Query: 341 -------------STTSTATTQMFHEDAAGG-------WQLVAVDVNKPQGRA------P 374
S ++ T + E+ AGG +A ++K +
Sbjct: 452 EDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNR 511
Query: 375 ACLQKM---MRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDL 431
C +K ++S+VF+ ++ +V ++ + AS +Y N+ + + A A LF
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD--TANKALLALFTA 569
Query: 432 EALLKIWCLGFTGYISSSLHKFELLLVIGTTLH-------VYPDLYHSQFTYFQVLRVVR 484
E LLK++ LG Y S ++F+ +V G L + L S ++LR+ +
Sbjct: 570 EMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFK 629
Query: 485 LIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR-------F 537
+ + +L + V + + + SL++ +I+ S + +Q+F D F
Sbjct: 630 ITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTF 689
Query: 538 TTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP--VVAIYFILYHLFATLILLSLFV 595
FP++ +++FQILT E W VM + A G P +V IYFI+ + ILL++F+
Sbjct: 690 DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFL 749
Query: 596 AVILDNLELDEDLKKLKQLKQSE---------ANADTKEKLPLRLRIFEKFPNRPQMVKI 646
A+ +DNL E L ++ ++ E A+ + K++L + + E ++ + +++
Sbjct: 750 AIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE---SKEEKIEL 806
Query: 647 SKLPSDFTVPKIRESFMKQFIDRQQQD 673
+ +D P + M + +D
Sbjct: 807 KSITADGESPPATKINMDDLQPNENED 833
Score = 104 bits (260), Expect = 7e-22
Identities = 94/357 (26%), Positives = 164/357 (45%), Gaps = 62/357 (17%)
Query: 885 VTYLDW----VMIIVTI-CSCISMMFESPFRRVMHAPT---LQIAEYVFVIFMSIELNLK 936
++ ++W ++I++TI +C+++ PF T L+ EY+F+I ++E LK
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 937 IMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQL-----------L 985
++A GL F P A +R+ ++D I +V L F + Q A+ L L
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGL-FSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 986 MVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAK 1045
R LRPLR+ VP ++ V+ + + +++L+L +++++A G++LF GK+ K
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 1046 C-------------NDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWAN 1092
+DP+ E +G N +V K PG W
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCK-------PG-----------WDG 338
Query: 1093 PRN--FNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVG-PIHGIYIHVFVFLGCMIGLT 1149
P++ NFDN AML +F+ ++++GW +V + VG IY + +G L
Sbjct: 339 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLN 398
Query: 1150 LFVGVVIANFNENKGTALLTVD-------QRRWEDLKSRLK-IAQPLHLPPRPDNDG 1198
L +GV+ F++ + A D Q+ EDLK L I Q + P +++G
Sbjct: 399 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEG 455
Score = 100 bits (248), Expect = 2e-20
Identities = 125/615 (20%), Positives = 257/615 (41%), Gaps = 86/615 (13%)
Query: 33 INKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHI 92
+N +L+ ++S IS+ P+ +H ++ F D + ++T E+ KM
Sbjct: 897 VNDTIFTNLILFFILLSSISLAAEDPV--QHTSFRNHILFYFDIVFTTIFTIEIALKMTA 954
Query: 93 RGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIR 152
G S+ ++ + + D L VS+ L F I Q S +++I R L ++R
Sbjct: 955 YGAFLHKGSFCRNYFNILD-----LLVVSVSLISFGI-----QSSAINVVKILRVLRVLR 1004
Query: 153 AFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDT 212
R R + + + + + I ++ I ++ +GVQ+F Y C + +
Sbjct: 1005 PLRAINRAKGLK-HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS-DSS 1062
Query: 213 KPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFT 272
K I T+ E++ P ++ + F+ + ++
Sbjct: 1063 KQTEAECKGNYI--TYKDGEVDHPIIQPRSWENSKFD-------------FDNVLAAMMA 1107
Query: 273 VYEAASQEGWVFLMYRAIDSFPRWRSYFY---------FITLIFFLAWLVKNVFIAVIIE 323
++ ++ EGW L+YR+IDS + Y FI I +A+ + N+F+ +I
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 324 TFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPACLQKMMRS 383
TF E Q +Q + + + + A + + P+ + + ++ S
Sbjct: 1168 TFQE---QGEQEYKNCELDKNQRQCVEYALKARPLRRYI------PKNQHQYKVWYVVNS 1218
Query: 384 SVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFT 443
+ F + ++ ++ I A +Y G++ + + + FT LF +E +LK+
Sbjct: 1219 TYFEYLMFVLILLNTICLAMQHY-GQSCLFKI-AMNILNMLFTGLFTVEMILKLIAFKPK 1276
Query: 444 GYISSSLHKFELLLVIGTTLHVYPDLYHS-------QFTYFQVLRVVRLIKI---SPALE 493
Y + + F+ L+V+G+ + + ++ T+F++ RV+RL+K+ +
Sbjct: 1277 HYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIR 1336
Query: 494 DFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVE-----ELDR---FTTFPRAFM 545
++ + L + + L + + I +Q+F + E++R F TFP+A +
Sbjct: 1337 TLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVL 1396
Query: 546 SMFQILTQEGWVDVMDQTLNAVGHMWAP-----------------VVAIYFILYHLFATL 588
+F+ T E W D+M + G AP YFI +++
Sbjct: 1397 LLFRCATGEAWQDIMLACMP--GKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAF 1454
Query: 589 ILLSLFVAVILDNLE 603
++++LFVAVI+DN +
Sbjct: 1455 LIINLFVAVIMDNFD 1469
Score = 78.2 bits (191), Expect = 7e-14
Identities = 57/250 (22%), Positives = 122/250 (48%), Gaps = 17/250 (6%)
Query: 1206 ITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSP 1265
+ + F+ I L+ L + S ++ + +T T + +F E+ +K+ ++
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1266 AGFWQSRRNRYDLLVTSLGVVWVVL-HFALLNAYTYMMGACVIVFRFFSICGKHVTLKML 1324
++ S NR+D V G++ +L +++ + CV + R F I +L L
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1325 LLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFG-TVKYGENINRHANFSSAGKAITVLF 1383
+ +++ S+ +++ +FL ++ ++ G+ LFG + E R + F + +++ +F
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVF 700
Query: 1384 RIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGAL--MYFCSFYVIIAYIMLNL 1441
+I+TGEDWN +M+D ++ A ++ G L +YF ++ YI+LN+
Sbjct: 701 QILTGEDWNSVMYDGIM-------------AYGGPSFPGMLVCIYFIILFICGNYILLNV 747
Query: 1442 LVAIIVENFS 1451
+AI V+N +
Sbjct: 748 FLAIAVDNLA 757
Score = 58.9 bits (141), Expect = 4e-08
Identities = 68/287 (23%), Positives = 120/287 (41%), Gaps = 68/287 (23%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDTL---LMFLYTAEMIAKMHIRGIVKGDSSYVKD 105
+ V +NT + EHY ++T DT L+ L+TAEM+ KM+ G+ +Y
Sbjct: 531 IFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL----QAYFVS 586
Query: 106 RWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRT 165
+ FD F+V + +L +I MSP G + + R + ++R F+I R+ +
Sbjct: 587 LFNRFDCFVVCGGILETILVETKI------MSPLG-ISVLRCVRLLRIFKIT-RYWNSLS 638
Query: 166 RITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIP 225
+ L S I S+ + L F++++ +LG+Q+FG G ++ +
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFG-------------GKFNFDEM--- 682
Query: 226 DTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFL 285
+ S F+ S+ TV++ + E W +
Sbjct: 683 -------------------------------QTRRSTFDNFPQSLLTVFQILTGEDWNSV 711
Query: 286 MYRAI-----DSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAE 327
MY I SFP YFI L +++ NVF+A+ ++ A+
Sbjct: 712 MYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLAD 758
Score = 51.2 bits (121), Expect = 9e-06
Identities = 64/306 (20%), Positives = 120/306 (39%), Gaps = 62/306 (20%)
Query: 890 WVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
W++I + + +++ E + A + + E+ LK+ + GL ++
Sbjct: 528 WLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSL 587
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVP---QMRKV 1006
F D F+ ++ + + + G + VLRC+R LRIFK+ + +
Sbjct: 588 FNRF----DCFVVCGGILETILVETKIMSPLG---ISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1007 VRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVS 1066
V L + + I + +LL +++F+ G+QLF GK F +
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGK------------------FNFDE- 681
Query: 1067 VSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVR-DVII 1125
R FDN ++L +F++L+ + W V D I+
Sbjct: 682 ------------------------MQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIM 717
Query: 1126 HRVGP-----IHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKS 1180
GP + IY + G I L +F+ + + N + + LT Q+ E+ K
Sbjct: 718 AYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAES---LTSAQKEEEEEKE 774
Query: 1181 RLKIAQ 1186
R K+A+
Sbjct: 775 RKKLAR 780
Score = 41.6 bits (96), Expect = 0.007
Identities = 57/300 (19%), Positives = 110/300 (36%), Gaps = 76/300 (25%)
Query: 1212 FKRTIALLVLAQSVLLSV----KWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMS--- 1264
F+ I L + A V L++ D + L + +F IF +E +K+IA
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLF 185
Query: 1265 -PAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGA-----------CVIVFRFF 1312
P + ++ N D ++ +G+ +L A +G V R
Sbjct: 186 HPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPL 245
Query: 1313 SICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLF--------------- 1357
+ +L+++L +++ +M I + + +++ YA G+ LF
Sbjct: 246 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIA 305
Query: 1358 -----------------------GTV-KYGENINRHA--NFSSAGKAITVLFRIVTGEDW 1391
GTV K G + +H NF + A+ +F+ +T E W
Sbjct: 306 DVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGW 365
Query: 1392 NKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFS 1451
++ YW D +YF + +I ++ +LNL++ ++ FS
Sbjct: 366 TDVL----------------YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS 409
>gi|193788530 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 9 [Homo sapiens]
Length = 2157
Score = 216 bits (550), Expect = 2e-55
Identities = 193/737 (26%), Positives = 342/737 (46%), Gaps = 64/737 (8%)
Query: 891 VMIIVTICSCISMMFESPFRRV-MHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
+++ + S IS+ E P + L A+YVF ++E+ LK+ A G F +
Sbjct: 905 LILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSF 964
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRE 1009
R++ ++D+ + VSLI + ++L VLR LRPLR ++ VV+
Sbjct: 965 CRNYFNILDLLVVSVSLISFGIQSSAINV---VKILRVLRVLRPLRAINRAKGLKHVVQC 1021
Query: 1010 LFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSK 1069
+F + I + I+ L +FA GVQLF GKL C+D + +C G +
Sbjct: 1022 VFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNY-------- 1073
Query: 1070 NLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEV--RDVIIHR 1127
+ + GE PR W N + F+FDNV AM+ALF V + +GW E+ R + H
Sbjct: 1074 ---ITYKDGEVDHPIIQPRSWENSK-FDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHT 1129
Query: 1128 --VGPIH------GIYIHVFVFLGCMIGLTLFVGVVIANFNE--NKGTALLTVDQRRWED 1177
GPI+ I+ +++ + + +FVG VI F E + +D+ + +
Sbjct: 1130 EDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQC 1189
Query: 1178 LKSRLKIAQPL--HLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVK-WDVE 1234
++ LK A+PL ++P + + K++ + +F+ + +L+L ++ L+++ +
Sbjct: 1190 VEYALK-ARPLRRYIP----KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQS 1244
Query: 1235 DPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFAL 1294
+ + ++++FT +F +E+ +K+IA P ++ N +D L+ +V + +
Sbjct: 1245 CLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVN 1304
Query: 1295 LNAYTYMMGA---------CVIVFRFF------SICGKHVTLKMLLLTVVVSMYKSFFII 1339
+T + + FR F + + ++ LL T + S ++
Sbjct: 1305 PAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVA 1364
Query: 1340 VGMFLLLLCYAFAGVVLFGTVKYGE--NINRHANFSSAGKAITVLFRIVTGEDWNKIMHD 1397
+ + +L YA G+ +FG + + INR+ NF + +A+ +LFR TGE W IM
Sbjct: 1365 LLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLA 1424
Query: 1398 CMVQ---PPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFY 1454
CM P P T T CG+ + A+ YF SFY++ A++++NL VA+I++NF Y
Sbjct: 1425 CMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFD--Y 1481
Query: 1455 STEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEV-DLDKDKLLFK 1513
T + +L + L F+ IW D + +G I V LLR ++ L L ++ K
Sbjct: 1482 LTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACK 1541
Query: 1514 HMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEE----EVAK 1569
+ L++ G V F+ L L ++ I+ A + E E A
Sbjct: 1542 RLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQAN 1601
Query: 1570 QTIRMWLKKCLKRIRAK 1586
+ +R +KK KR K
Sbjct: 1602 EELRAIIKKIWKRTSMK 1618
Score = 147 bits (370), Expect = 1e-34
Identities = 149/687 (21%), Positives = 296/687 (43%), Gaps = 102/687 (14%)
Query: 74 LDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIV 133
++ L + ++T E K+ G++ ++Y+++ W + D +V V L + E A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVV---VGLFSAILEQATKA 218
Query: 134 DQMSPWGMLRIPRPLIMIRAFRIYFRFEL----PRTRIT-NILKRSGEQIWSVSIFLLFF 188
D + G + +RAFR+ L P ++ N + ++ + +++ +LF
Sbjct: 219 DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 278
Query: 189 LLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDL 248
+++Y I+G+++F + N +V P C+ E G QC G C
Sbjct: 279 IIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSP---CALETGHGRQCQNGTVCKP- 334
Query: 249 EDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFF 308
G + G + F+ ++ TV++ + EGW ++Y D+ R + YF+TLI
Sbjct: 335 ---GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIII 391
Query: 309 LAWLVKNVFIAVIIETF------AEIRVQFQQM---------------WGSRS------- 340
++ V N+ + V+ F A+ R FQ++ W +++
Sbjct: 392 GSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPEN 451
Query: 341 -------------STTSTATTQMFHEDAAGG-------WQLVAVDVNKPQGRA------P 374
S ++ T + E+ AGG +A ++K +
Sbjct: 452 EDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNR 511
Query: 375 ACLQKM---MRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDL 431
C +K ++S+VF+ ++ +V ++ + AS +Y N+ + + A A LF
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD--TANKALLALFTA 569
Query: 432 EALLKIWCLGFTGYISSSLHKFELLLVIGTTLH-------VYPDLYHSQFTYFQVLRVVR 484
E LLK++ LG Y S ++F+ +V G L + L S ++LR+ +
Sbjct: 570 EMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFK 629
Query: 485 LIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR-------F 537
+ + +L + V + + + SL++ +I+ S + +Q+F D F
Sbjct: 630 ITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTF 689
Query: 538 TTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP--VVAIYFILYHLFATLILLSLFV 595
FP++ +++FQILT E W VM + A G P +V IYFI+ + ILL++F+
Sbjct: 690 DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFL 749
Query: 596 AVILDNLELDEDLKKLKQLKQSE---------ANADTKEKLPLRLRIFEKFPNRPQMVKI 646
A+ +DNL E L ++ ++ E A+ + K++L + + E ++ + +++
Sbjct: 750 AIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE---SKEEKIEL 806
Query: 647 SKLPSDFTVPKIRESFMKQFIDRQQQD 673
+ +D P + M + +D
Sbjct: 807 KSITADGESPPATKINMDDLQPNENED 833
Score = 104 bits (260), Expect = 7e-22
Identities = 94/357 (26%), Positives = 164/357 (45%), Gaps = 62/357 (17%)
Query: 885 VTYLDW----VMIIVTI-CSCISMMFESPFRRVMHAPT---LQIAEYVFVIFMSIELNLK 936
++ ++W ++I++TI +C+++ PF T L+ EY+F+I ++E LK
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 937 IMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQL-----------L 985
++A GL F P A +R+ ++D I +V L F + Q A+ L L
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGL-FSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 986 MVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAK 1045
R LRPLR+ VP ++ V+ + + +++L+L +++++A G++LF GK+ K
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 1046 C-------------NDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWAN 1092
+DP+ E +G N +V K PG W
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCK-------PG-----------WDG 338
Query: 1093 PRN--FNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVG-PIHGIYIHVFVFLGCMIGLT 1149
P++ NFDN AML +F+ ++++GW +V + VG IY + +G L
Sbjct: 339 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLN 398
Query: 1150 LFVGVVIANFNENKGTALLTVD-------QRRWEDLKSRLK-IAQPLHLPPRPDNDG 1198
L +GV+ F++ + A D Q+ EDLK L I Q + P +++G
Sbjct: 399 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEG 455
Score = 95.9 bits (237), Expect = 3e-19
Identities = 127/626 (20%), Positives = 258/626 (41%), Gaps = 97/626 (15%)
Query: 33 INKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHI 92
+N +L+ ++S IS+ P+ +H ++ D + ++T E+I KM
Sbjct: 897 VNDTIFTNLILFFILLSSISLAAEDPV--QHTSFRNHILGNADYVFTSIFTLEIILKMTA 954
Query: 93 RGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIR 152
G S+ ++ + + D L VS+ L F I Q S +++I R L ++R
Sbjct: 955 YGAFLHKGSFCRNYFNILD-----LLVVSVSLISFGI-----QSSAINVVKILRVLRVLR 1004
Query: 153 AFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDT 212
R R + + + + + I ++ I ++ +GVQ+F Y C + +
Sbjct: 1005 PLRAINRAKGLK-HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS-DSS 1062
Query: 213 KPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFT 272
K I T+ E++ P ++ + F+ + ++
Sbjct: 1063 KQTEAECKGNYI--TYKDGEVDHPIIQPRSWENSKFD-------------FDNVLAAMMA 1107
Query: 273 VYEAASQEGWVFLMYRAIDSFPRWRSYFY---------FITLIFFLAWLVKNVFIAVIIE 323
++ ++ EGW L+YR+IDS + Y FI I +A+ + N+F+ +I
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 324 TFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPACLQKMMRS 383
TF E Q +Q + + + + A + + P+ + + ++ S
Sbjct: 1168 TFQE---QGEQEYKNCELDKNQRQCVEYALKARPLRRYI------PKNQHQYKVWYVVNS 1218
Query: 384 SVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFT 443
+ F + ++ ++ I A +Y G++ + + + FT LF +E +LK+
Sbjct: 1219 TYFEYLMFVLILLNTICLAMQHY-GQSCLFKI-AMNILNMLFTGLFTVEMILKLIAFKPK 1276
Query: 444 GYISSSLHKFELLLVIGTTLHV----YPDLYHSQ--------------FTYFQVLRVVRL 485
Y + + F+ L+V+G+ + + H+Q T+F++ RV+RL
Sbjct: 1277 HYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRL 1336
Query: 486 IKI---SPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVE-----ELDR- 536
+K+ + ++ + L + + L + + I +Q+F + E++R
Sbjct: 1337 VKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRN 1396
Query: 537 --FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP-----------------VVAI 577
F TFP+A + +F+ T E W D+M + G AP
Sbjct: 1397 NNFQTFPQAVLLLFRCATGEAWQDIMLACMP--GKKCAPESEPSNSTEGETPCGSSFAVF 1454
Query: 578 YFILYHLFATLILLSLFVAVILDNLE 603
YFI +++ ++++LFVAVI+DN +
Sbjct: 1455 YFISFYMLCAFLIINLFVAVIMDNFD 1480
Score = 78.2 bits (191), Expect = 7e-14
Identities = 57/250 (22%), Positives = 122/250 (48%), Gaps = 17/250 (6%)
Query: 1206 ITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSP 1265
+ + F+ I L+ L + S ++ + +T T + +F E+ +K+ ++
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1266 AGFWQSRRNRYDLLVTSLGVVWVVL-HFALLNAYTYMMGACVIVFRFFSICGKHVTLKML 1324
++ S NR+D V G++ +L +++ + CV + R F I +L L
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1325 LLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFG-TVKYGENINRHANFSSAGKAITVLF 1383
+ +++ S+ +++ +FL ++ ++ G+ LFG + E R + F + +++ +F
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVF 700
Query: 1384 RIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGAL--MYFCSFYVIIAYIMLNL 1441
+I+TGEDWN +M+D ++ A ++ G L +YF ++ YI+LN+
Sbjct: 701 QILTGEDWNSVMYDGIM-------------AYGGPSFPGMLVCIYFIILFICGNYILLNV 747
Query: 1442 LVAIIVENFS 1451
+AI V+N +
Sbjct: 748 FLAIAVDNLA 757
Score = 58.9 bits (141), Expect = 4e-08
Identities = 68/287 (23%), Positives = 120/287 (41%), Gaps = 68/287 (23%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDTL---LMFLYTAEMIAKMHIRGIVKGDSSYVKD 105
+ V +NT + EHY ++T DT L+ L+TAEM+ KM+ G+ +Y
Sbjct: 531 IFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL----QAYFVS 586
Query: 106 RWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRT 165
+ FD F+V + +L +I MSP G + + R + ++R F+I R+ +
Sbjct: 587 LFNRFDCFVVCGGILETILVETKI------MSPLG-ISVLRCVRLLRIFKIT-RYWNSLS 638
Query: 166 RITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIP 225
+ L S I S+ + L F++++ +LG+Q+FG G ++ +
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFG-------------GKFNFDEM--- 682
Query: 226 DTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFL 285
+ S F+ S+ TV++ + E W +
Sbjct: 683 -------------------------------QTRRSTFDNFPQSLLTVFQILTGEDWNSV 711
Query: 286 MYRAI-----DSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAE 327
MY I SFP YFI L +++ NVF+A+ ++ A+
Sbjct: 712 MYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLAD 758
Score = 51.2 bits (121), Expect = 9e-06
Identities = 64/306 (20%), Positives = 120/306 (39%), Gaps = 62/306 (20%)
Query: 890 WVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
W++I + + +++ E + A + + E+ LK+ + GL ++
Sbjct: 528 WLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSL 587
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVP---QMRKV 1006
F D F+ ++ + + + G + VLRC+R LRIFK+ + +
Sbjct: 588 FNRF----DCFVVCGGILETILVETKIMSPLG---ISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1007 VRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVS 1066
V L + + I + +LL +++F+ G+QLF GK F +
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGK------------------FNFDE- 681
Query: 1067 VSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVR-DVII 1125
R FDN ++L +F++L+ + W V D I+
Sbjct: 682 ------------------------MQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIM 717
Query: 1126 HRVGP-----IHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKS 1180
GP + IY + G I L +F+ + + N + + LT Q+ E+ K
Sbjct: 718 AYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAES---LTSAQKEEEEEKE 774
Query: 1181 RLKIAQ 1186
R K+A+
Sbjct: 775 RKKLAR 780
Score = 48.9 bits (115), Expect = 4e-05
Identities = 57/275 (20%), Positives = 117/275 (42%), Gaps = 57/275 (20%)
Query: 379 KMMRSSVFHMFILSMVTVDVI-VAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKI 437
+++ ++F IL + + I +AA + + +FR A+ FT +F LE +LK+
Sbjct: 895 RIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHI--LGNADYVFTSIFTLEIILKM 952
Query: 438 WCLG---FTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFTYFQVLRVVRL------IKI 488
G G + LLV+ +L + + S ++LRV+R+ I
Sbjct: 953 TAYGAFLHKGSFCRNYFNILDLLVVSVSLISF-GIQSSAINVVKILRVLRVLRPLRAINR 1011
Query: 489 SPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMF------CFVE---------- 532
+ L+ V +F + +G++V+ T L + + I +Q+F C
Sbjct: 1012 AKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKG 1071
Query: 533 --------ELDRFTTFPR--------------AFMSMFQILTQEGWVDVMDQTLNAVGHM 570
E+D PR A M++F + T EGW +++ +++++
Sbjct: 1072 NYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTED 1131
Query: 571 WAPV------VAIYFILYHLFATLILLSLFVAVIL 599
P+ ++I+FI+Y + ++++FV ++
Sbjct: 1132 KGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
Score = 41.6 bits (96), Expect = 0.007
Identities = 57/300 (19%), Positives = 110/300 (36%), Gaps = 76/300 (25%)
Query: 1212 FKRTIALLVLAQSVLLSV----KWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMS--- 1264
F+ I L + A V L++ D + L + +F IF +E +K+IA
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLF 185
Query: 1265 -PAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGA-----------CVIVFRFF 1312
P + ++ N D ++ +G+ +L A +G V R
Sbjct: 186 HPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPL 245
Query: 1313 SICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLF--------------- 1357
+ +L+++L +++ +M I + + +++ YA G+ LF
Sbjct: 246 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIA 305
Query: 1358 -----------------------GTV-KYGENINRHA--NFSSAGKAITVLFRIVTGEDW 1391
GTV K G + +H NF + A+ +F+ +T E W
Sbjct: 306 DVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGW 365
Query: 1392 NKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFS 1451
++ YW D +YF + +I ++ +LNL++ ++ FS
Sbjct: 366 TDVL----------------YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS 409
>gi|193788526 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 6 [Homo sapiens]
Length = 2158
Score = 216 bits (549), Expect = 2e-55
Identities = 183/681 (26%), Positives = 326/681 (47%), Gaps = 61/681 (8%)
Query: 921 AEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAES 980
A+YVF ++E+ LK+ A G F + R++ ++D+ + VSLI +
Sbjct: 956 ADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINV-- 1013
Query: 981 GAQLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFA 1040
++L VLR LRPLR ++ VV+ +F + I + I+ L +FA GVQLF
Sbjct: 1014 -VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFK 1072
Query: 1041 GKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDN 1100
GKL C+D + +C G + + + GE PR W N + F+FDN
Sbjct: 1073 GKLYTCSDSSKQTEAECKGNY-----------ITYKDGEVDHPIIQPRSWENSK-FDFDN 1120
Query: 1101 VGNAMLALFEVLSLKGWVEV--RDVIIHR--VGPIH------GIYIHVFVFLGCMIGLTL 1150
V AM+ALF V + +GW E+ R + H GPI+ I+ +++ + + +
Sbjct: 1121 VLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNI 1180
Query: 1151 FVGVVIANFNE--NKGTALLTVDQRRWEDLKSRLKIAQPL--HLPPRPDNDGFRAKMYDI 1206
FVG VI F E + +D+ + + ++ LK A+PL ++P + + K++ +
Sbjct: 1181 FVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALK-ARPLRRYIP----KNQHQYKVWYV 1235
Query: 1207 TQHPFFKRTIALLVLAQSVLLSVK-WDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSP 1265
+F+ + +L+L ++ L+++ + + + ++++FT +F +E+ +K+IA P
Sbjct: 1236 VNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKP 1295
Query: 1266 AGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGA---------CVIVFRFF---- 1312
++ N +D L+ +V + + +T + + FR F
Sbjct: 1296 KHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMR 1355
Query: 1313 --SICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGE--NINR 1368
+ + ++ LL T + S ++ + + +L YA G+ +FG + + INR
Sbjct: 1356 LVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINR 1415
Query: 1369 HANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQ---PPFCTPDEFTYWATDCGNYAGALM 1425
+ NF + +A+ +LFR TGE W IM CM P P T T CG+ + A+
Sbjct: 1416 NNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGS-SFAVF 1474
Query: 1426 YFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVI 1485
YF SFY++ A++++NL VA+I++NF Y T + +L + L F+ IW D + +G I
Sbjct: 1475 YFISFYMLCAFLIINLFVAVIMDNFD--YLTRDWSILGPHHLDEFKRIWAEYDPEAKGRI 1532
Query: 1486 PTFRVKFLLRLLRGRLEV-DLDKDKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVDI 1544
V LLR ++ L L ++ K + L++ G V F+ L L ++ I
Sbjct: 1533 KHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRI 1592
Query: 1545 RKSLQLEELLAREQLEYTIEE 1565
+ LE+ A E+L I++
Sbjct: 1593 KTEGNLEQ--ANEELRAIIKK 1611
Score = 147 bits (370), Expect = 1e-34
Identities = 149/687 (21%), Positives = 296/687 (43%), Gaps = 102/687 (14%)
Query: 74 LDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIV 133
++ L + ++T E K+ G++ ++Y+++ W + D +V V L + E A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVV---VGLFSAILEQATKA 218
Query: 134 DQMSPWGMLRIPRPLIMIRAFRIYFRFEL----PRTRIT-NILKRSGEQIWSVSIFLLFF 188
D + G + +RAFR+ L P ++ N + ++ + +++ +LF
Sbjct: 219 DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 278
Query: 189 LLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDL 248
+++Y I+G+++F + N +V P C+ E G QC G C
Sbjct: 279 IIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSP---CALETGHGRQCQNGTVCKP- 334
Query: 249 EDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFF 308
G + G + F+ ++ TV++ + EGW ++Y D+ R + YF+TLI
Sbjct: 335 ---GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIII 391
Query: 309 LAWLVKNVFIAVIIETF------AEIRVQFQQM---------------WGSRS------- 340
++ V N+ + V+ F A+ R FQ++ W +++
Sbjct: 392 GSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPEN 451
Query: 341 -------------STTSTATTQMFHEDAAGG-------WQLVAVDVNKPQGRA------P 374
S ++ T + E+ AGG +A ++K +
Sbjct: 452 EDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNR 511
Query: 375 ACLQKM---MRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDL 431
C +K ++S+VF+ ++ +V ++ + AS +Y N+ + + A A LF
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD--TANKALLALFTA 569
Query: 432 EALLKIWCLGFTGYISSSLHKFELLLVIGTTLH-------VYPDLYHSQFTYFQVLRVVR 484
E LLK++ LG Y S ++F+ +V G L + L S ++LR+ +
Sbjct: 570 EMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFK 629
Query: 485 LIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR-------F 537
+ + +L + V + + + SL++ +I+ S + +Q+F D F
Sbjct: 630 ITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTF 689
Query: 538 TTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP--VVAIYFILYHLFATLILLSLFV 595
FP++ +++FQILT E W VM + A G P +V IYFI+ + ILL++F+
Sbjct: 690 DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFL 749
Query: 596 AVILDNLELDEDLKKLKQLKQSE---------ANADTKEKLPLRLRIFEKFPNRPQMVKI 646
A+ +DNL E L ++ ++ E A+ + K++L + + E ++ + +++
Sbjct: 750 AIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE---SKEEKIEL 806
Query: 647 SKLPSDFTVPKIRESFMKQFIDRQQQD 673
+ +D P + M + +D
Sbjct: 807 KSITADGESPPATKINMDDLQPNENED 833
Score = 104 bits (260), Expect = 7e-22
Identities = 94/357 (26%), Positives = 164/357 (45%), Gaps = 62/357 (17%)
Query: 885 VTYLDW----VMIIVTI-CSCISMMFESPFRRVMHAPT---LQIAEYVFVIFMSIELNLK 936
++ ++W ++I++TI +C+++ PF T L+ EY+F+I ++E LK
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 937 IMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQL-----------L 985
++A GL F P A +R+ ++D I +V L F + Q A+ L L
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGL-FSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 986 MVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAK 1045
R LRPLR+ VP ++ V+ + + +++L+L +++++A G++LF GK+ K
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 1046 C-------------NDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWAN 1092
+DP+ E +G N +V K PG W
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCK-------PG-----------WDG 338
Query: 1093 PRN--FNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVG-PIHGIYIHVFVFLGCMIGLT 1149
P++ NFDN AML +F+ ++++GW +V + VG IY + +G L
Sbjct: 339 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLN 398
Query: 1150 LFVGVVIANFNENKGTALLTVD-------QRRWEDLKSRLK-IAQPLHLPPRPDNDG 1198
L +GV+ F++ + A D Q+ EDLK L I Q + P +++G
Sbjct: 399 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEG 455
Score = 91.3 bits (225), Expect = 7e-18
Identities = 120/584 (20%), Positives = 241/584 (41%), Gaps = 95/584 (16%)
Query: 75 DTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVD 134
D + ++T E+I KM G S+ ++ + + D L VS+ L F I
Sbjct: 957 DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILD-----LLVVSVSLISFGI----- 1006
Query: 135 QMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGI 194
Q S +++I R L ++R R R + + + + + I ++ I ++
Sbjct: 1007 QSSAINVVKILRVLRVLRPLRAINRAKGLK-HVVQCVFVAIRTIGNIVIVTTLLQFMFAC 1065
Query: 195 LGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLS 254
+GVQ+F Y C + +K I T+ E++ P ++ +
Sbjct: 1066 IGVQLFKGKLYTCS-DSSKQTEAECKGNYI--TYKDGEVDHPIIQPRSWENSKFD----- 1117
Query: 255 RQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFY---------FITL 305
F+ + ++ ++ ++ EGW L+YR+IDS + Y FI
Sbjct: 1118 --------FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIY 1169
Query: 306 IFFLAWLVKNVFIAVIIETFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVD 365
I +A+ + N+F+ +I TF E Q +Q + + + + A + +
Sbjct: 1170 IIIIAFFMMNIFVGFVIVTFQE---QGEQEYKNCELDKNQRQCVEYALKARPLRRYI--- 1223
Query: 366 VNKPQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAF 425
P+ + + ++ S+ F + ++ ++ I A +Y G++ + + + F
Sbjct: 1224 ---PKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHY-GQSCLFKI-AMNILNMLF 1278
Query: 426 TVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLHV----YPDLYHSQ-------- 473
T LF +E +LK+ Y + + F+ L+V+G+ + + H+Q
Sbjct: 1279 TGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAE 1338
Query: 474 ------FTYFQVLRVVRLIKI---SPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAIS 524
T+F++ RV+RL+K+ + ++ + L + + L + + I
Sbjct: 1339 ENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIG 1398
Query: 525 LQMFCFVE-----ELDR---FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP--- 573
+Q+F + E++R F TFP+A + +F+ T E W D+M + G AP
Sbjct: 1399 MQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMP--GKKCAPESE 1456
Query: 574 --------------VVAIYFILYHLFATLILLSLFVAVILDNLE 603
YFI +++ ++++LFVAVI+DN +
Sbjct: 1457 PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFD 1500
Score = 78.2 bits (191), Expect = 7e-14
Identities = 57/250 (22%), Positives = 122/250 (48%), Gaps = 17/250 (6%)
Query: 1206 ITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSP 1265
+ + F+ I L+ L + S ++ + +T T + +F E+ +K+ ++
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1266 AGFWQSRRNRYDLLVTSLGVVWVVL-HFALLNAYTYMMGACVIVFRFFSICGKHVTLKML 1324
++ S NR+D V G++ +L +++ + CV + R F I +L L
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1325 LLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFG-TVKYGENINRHANFSSAGKAITVLF 1383
+ +++ S+ +++ +FL ++ ++ G+ LFG + E R + F + +++ +F
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVF 700
Query: 1384 RIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGAL--MYFCSFYVIIAYIMLNL 1441
+I+TGEDWN +M+D ++ A ++ G L +YF ++ YI+LN+
Sbjct: 701 QILTGEDWNSVMYDGIM-------------AYGGPSFPGMLVCIYFIILFICGNYILLNV 747
Query: 1442 LVAIIVENFS 1451
+AI V+N +
Sbjct: 748 FLAIAVDNLA 757
Score = 58.9 bits (141), Expect = 4e-08
Identities = 68/287 (23%), Positives = 120/287 (41%), Gaps = 68/287 (23%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDTL---LMFLYTAEMIAKMHIRGIVKGDSSYVKD 105
+ V +NT + EHY ++T DT L+ L+TAEM+ KM+ G+ +Y
Sbjct: 531 IFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL----QAYFVS 586
Query: 106 RWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRT 165
+ FD F+V + +L +I MSP G + + R + ++R F+I R+ +
Sbjct: 587 LFNRFDCFVVCGGILETILVETKI------MSPLG-ISVLRCVRLLRIFKIT-RYWNSLS 638
Query: 166 RITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIP 225
+ L S I S+ + L F++++ +LG+Q+FG G ++ +
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFG-------------GKFNFDEM--- 682
Query: 226 DTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFL 285
+ S F+ S+ TV++ + E W +
Sbjct: 683 -------------------------------QTRRSTFDNFPQSLLTVFQILTGEDWNSV 711
Query: 286 MYRAI-----DSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAE 327
MY I SFP YFI L +++ NVF+A+ ++ A+
Sbjct: 712 MYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLAD 758
Score = 51.2 bits (121), Expect = 9e-06
Identities = 64/306 (20%), Positives = 120/306 (39%), Gaps = 62/306 (20%)
Query: 890 WVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
W++I + + +++ E + A + + E+ LK+ + GL ++
Sbjct: 528 WLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSL 587
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVP---QMRKV 1006
F D F+ ++ + + + G + VLRC+R LRIFK+ + +
Sbjct: 588 FNRF----DCFVVCGGILETILVETKIMSPLG---ISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1007 VRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVS 1066
V L + + I + +LL +++F+ G+QLF GK F +
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGK------------------FNFDE- 681
Query: 1067 VSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVR-DVII 1125
R FDN ++L +F++L+ + W V D I+
Sbjct: 682 ------------------------MQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIM 717
Query: 1126 HRVGP-----IHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKS 1180
GP + IY + G I L +F+ + + N + + LT Q+ E+ K
Sbjct: 718 AYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAES---LTSAQKEEEEEKE 774
Query: 1181 RLKIAQ 1186
R K+A+
Sbjct: 775 RKKLAR 780
Score = 50.4 bits (119), Expect = 1e-05
Identities = 59/296 (19%), Positives = 122/296 (41%), Gaps = 79/296 (26%)
Query: 379 KMMRSSVFHMFILSMVTVDVI-VAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKI 437
+++ ++F IL + + I +AA + + +FR + ++ FT +F +E LKI
Sbjct: 895 RIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHI--LFYFDIVFTTIFTIEIALKI 952
Query: 438 WCLGFTGYISSSLHKFELLL---VIGTTLH---------------------VYPDLYHSQ 473
LG Y+ +S+ E++L G LH + + S
Sbjct: 953 --LGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA 1010
Query: 474 FTYFQVLRVVRL------IKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQM 527
++LRV+R+ I + L+ V +F + +G++V+ T L + + I +Q+
Sbjct: 1011 INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQL 1070
Query: 528 F------CFVE------------------ELDRFTTFPR--------------AFMSMFQ 549
F C E+D PR A M++F
Sbjct: 1071 FKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFT 1130
Query: 550 ILTQEGWVDVMDQTLNAVGHMWAPV------VAIYFILYHLFATLILLSLFVAVIL 599
+ T EGW +++ +++++ P+ ++I+FI+Y + ++++FV ++
Sbjct: 1131 VSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1186
Score = 48.5 bits (114), Expect = 6e-05
Identities = 73/315 (23%), Positives = 119/315 (37%), Gaps = 73/315 (23%)
Query: 33 INKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMF---LYTAEMIAK 89
+N + L+ + +++ I + M +HY ++ L M L+T EMI K
Sbjct: 1236 VNSTYFEYLMFVLILLNTICLAM------QHYGQSCLFKIAMNILNMLFTGLFTVEMILK 1289
Query: 90 MHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLI 149
+ I Y D W FD +V V + + A+ Q SP M I
Sbjct: 1290 L----IAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHT-QCSP-SMNAEENSRI 1343
Query: 150 MIRAFRIY---------FRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF 200
I FR++ R E RT + +K S + + V++ ++ +Y ++G+Q+F
Sbjct: 1344 SITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK-SFQALPYVALLIVMLFFIYAVIGMQVF 1402
Query: 201 GTFTYHCVVNDTKPGNVTWNSLAIPDT-----HCSPELEEGYQ-----CPPGFKCMDLED 250
G +NDT N N P C+ E +Q C PG KC +
Sbjct: 1403 GKI----ALNDTTEINRNNNFQTFPQAVLLLFRCA--TGEAWQDIMLACMPGKKCAPESE 1456
Query: 251 LGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLA 310
S + G G+S + FYFI+ A
Sbjct: 1457 PSNSTE-----GETPCGSSF---------------------------AVFYFISFYMLCA 1484
Query: 311 WLVKNVFIAVIIETF 325
+L+ N+F+AVI++ F
Sbjct: 1485 FLIINLFVAVIMDNF 1499
Score = 47.0 bits (110), Expect = 2e-04
Identities = 68/318 (21%), Positives = 117/318 (36%), Gaps = 77/318 (24%)
Query: 1196 NDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVP------LATMSVVFT 1249
N+ FR + + I F I +L S+ L+ EDPV L +VFT
Sbjct: 886 NNRFRLQCHRIVNDTIFTNLILFFILLSSISLAA----EDPVQHTSFRNHILFYFDIVFT 941
Query: 1250 FIFVLEVTMKIIA------------------------MSPAGFWQSRRNRYDLLVTSLGV 1285
IF +E+ +KI+ + F ++ N DLLV S+ +
Sbjct: 942 TIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSL 1001
Query: 1286 VWVVLHFALLNAYTYMMGACVIVFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLL 1345
+ + + +N + + V R + LK ++ V V++ I++ LL
Sbjct: 1002 ISFGIQSSAINVVKIL--RVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLL 1059
Query: 1346 LLCYAFAGVVLFG----------------------TVKYGEN----------INRHANFS 1373
+A GV LF T K GE N +F
Sbjct: 1060 QFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFD 1119
Query: 1374 SAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGAL-MYFCSFYV 1432
+ A+ LF + T E W ++++ + D T NY + ++F + +
Sbjct: 1120 NVLAAMMALFTVSTFEGWPELLYRSI--------DSHTEDKGPIYNYRVEISIFFIIYII 1171
Query: 1433 IIAYIMLNLLVAIIVENF 1450
IIA+ M+N+ V ++ F
Sbjct: 1172 IIAFFMMNIFVGFVIVTF 1189
Score = 41.6 bits (96), Expect = 0.007
Identities = 57/300 (19%), Positives = 110/300 (36%), Gaps = 76/300 (25%)
Query: 1212 FKRTIALLVLAQSVLLSV----KWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMS--- 1264
F+ I L + A V L++ D + L + +F IF +E +K+IA
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLF 185
Query: 1265 -PAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGA-----------CVIVFRFF 1312
P + ++ N D ++ +G+ +L A +G V R
Sbjct: 186 HPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPL 245
Query: 1313 SICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLF--------------- 1357
+ +L+++L +++ +M I + + +++ YA G+ LF
Sbjct: 246 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIA 305
Query: 1358 -----------------------GTV-KYGENINRHA--NFSSAGKAITVLFRIVTGEDW 1391
GTV K G + +H NF + A+ +F+ +T E W
Sbjct: 306 DVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGW 365
Query: 1392 NKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFS 1451
++ YW D +YF + +I ++ +LNL++ ++ FS
Sbjct: 366 TDVL----------------YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS 409
>gi|120433602 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 18 [Homo sapiens]
Length = 2138
Score = 215 bits (547), Expect = 3e-55
Identities = 188/712 (26%), Positives = 336/712 (47%), Gaps = 62/712 (8%)
Query: 891 VMIIVTICSCISMMFESPFRRV-MHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
+++ + S IS+ E P + L + VF +IE+ LK+ A G F +
Sbjct: 905 LILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSF 964
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRE 1009
R++ ++D+ + VSLI + ++L VLR LRPLR ++ VV+
Sbjct: 965 CRNYFNILDLLVVSVSLISFGIQSSAINV---VKILRVLRVLRPLRAINRAKGLKHVVQC 1021
Query: 1010 LFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSK 1069
+F + I + I+ L +FA GVQLF GKL C+D + +C G +
Sbjct: 1022 VFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNY-------- 1073
Query: 1070 NLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEV--RDVIIHR 1127
+ + GE PR W N + F+FDNV AM+ALF V + +GW E+ R + H
Sbjct: 1074 ---ITYKDGEVDHPIIQPRSWENSK-FDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHT 1129
Query: 1128 --VGPIH------GIYIHVFVFLGCMIGLTLFVGVVIANFNE--NKGTALLTVDQRRWED 1177
GPI+ I+ +++ + + +FVG VI F E + +D+ + +
Sbjct: 1130 EDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQC 1189
Query: 1178 LKSRLKIAQPL--HLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVK-WDVE 1234
++ LK A+PL ++P + + K++ + +F+ + +L+L ++ L+++ +
Sbjct: 1190 VEYALK-ARPLRRYIP----KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQS 1244
Query: 1235 DPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFAL 1294
+ + ++++FT +F +E+ +K+IA P ++ N +D L+ +V + +
Sbjct: 1245 CLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVN 1304
Query: 1295 LNAYTYMMGA---------CVIVFRFF------SICGKHVTLKMLLLTVVVSMYKSFFII 1339
+T + + FR F + + ++ LL T + S ++
Sbjct: 1305 PAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVA 1364
Query: 1340 VGMFLLLLCYAFAGVVLFGTVKYGE--NINRHANFSSAGKAITVLFRIVTGEDWNKIMHD 1397
+ + +L YA G+ +FG + + INR+ NF + +A+ +LFR TGE W IM
Sbjct: 1365 LLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLA 1424
Query: 1398 CMVQ---PPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFY 1454
CM P P T T CG+ + A+ YF SFY++ A++++NL VA+I++NF Y
Sbjct: 1425 CMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFD--Y 1481
Query: 1455 STEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEV-DLDKDKLLFK 1513
T + +L + L F+ IW D + +G I V LLR ++ L L ++ K
Sbjct: 1482 LTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACK 1541
Query: 1514 HMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEE 1565
+ L++ G V F+ L L ++ I+ LE+ A E+L I++
Sbjct: 1542 RLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQ--ANEELRAIIKK 1591
Score = 147 bits (370), Expect = 1e-34
Identities = 149/687 (21%), Positives = 296/687 (43%), Gaps = 102/687 (14%)
Query: 74 LDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIV 133
++ L + ++T E K+ G++ ++Y+++ W + D +V V L + E A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVV---VGLFSAILEQATKA 218
Query: 134 DQMSPWGMLRIPRPLIMIRAFRIYFRFEL----PRTRIT-NILKRSGEQIWSVSIFLLFF 188
D + G + +RAFR+ L P ++ N + ++ + +++ +LF
Sbjct: 219 DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 278
Query: 189 LLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDL 248
+++Y I+G+++F + N +V P C+ E G QC G C
Sbjct: 279 IIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSP---CALETGHGRQCQNGTVCKP- 334
Query: 249 EDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFF 308
G + G + F+ ++ TV++ + EGW ++Y D+ R + YF+TLI
Sbjct: 335 ---GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIII 391
Query: 309 LAWLVKNVFIAVIIETF------AEIRVQFQQM---------------WGSRS------- 340
++ V N+ + V+ F A+ R FQ++ W +++
Sbjct: 392 GSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPEN 451
Query: 341 -------------STTSTATTQMFHEDAAGG-------WQLVAVDVNKPQGRA------P 374
S ++ T + E+ AGG +A ++K +
Sbjct: 452 EDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNR 511
Query: 375 ACLQKM---MRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDL 431
C +K ++S+VF+ ++ +V ++ + AS +Y N+ + + A A LF
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD--TANKALLALFTA 569
Query: 432 EALLKIWCLGFTGYISSSLHKFELLLVIGTTLH-------VYPDLYHSQFTYFQVLRVVR 484
E LLK++ LG Y S ++F+ +V G L + L S ++LR+ +
Sbjct: 570 EMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFK 629
Query: 485 LIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR-------F 537
+ + +L + V + + + SL++ +I+ S + +Q+F D F
Sbjct: 630 ITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTF 689
Query: 538 TTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP--VVAIYFILYHLFATLILLSLFV 595
FP++ +++FQILT E W VM + A G P +V IYFI+ + ILL++F+
Sbjct: 690 DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFL 749
Query: 596 AVILDNLELDEDLKKLKQLKQSE---------ANADTKEKLPLRLRIFEKFPNRPQMVKI 646
A+ +DNL E L ++ ++ E A+ + K++L + + E ++ + +++
Sbjct: 750 AIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE---SKEEKIEL 806
Query: 647 SKLPSDFTVPKIRESFMKQFIDRQQQD 673
+ +D P + M + +D
Sbjct: 807 KSITADGESPPATKINMDDLQPNENED 833
Score = 104 bits (260), Expect = 7e-22
Identities = 94/357 (26%), Positives = 164/357 (45%), Gaps = 62/357 (17%)
Query: 885 VTYLDW----VMIIVTI-CSCISMMFESPFRRVMHAPT---LQIAEYVFVIFMSIELNLK 936
++ ++W ++I++TI +C+++ PF T L+ EY+F+I ++E LK
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 937 IMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQL-----------L 985
++A GL F P A +R+ ++D I +V L F + Q A+ L L
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGL-FSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 986 MVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAK 1045
R LRPLR+ VP ++ V+ + + +++L+L +++++A G++LF GK+ K
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 1046 C-------------NDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWAN 1092
+DP+ E +G N +V K PG W
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCK-------PG-----------WDG 338
Query: 1093 PRN--FNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVG-PIHGIYIHVFVFLGCMIGLT 1149
P++ NFDN AML +F+ ++++GW +V + VG IY + +G L
Sbjct: 339 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLN 398
Query: 1150 LFVGVVIANFNENKGTALLTVD-------QRRWEDLKSRLK-IAQPLHLPPRPDNDG 1198
L +GV+ F++ + A D Q+ EDLK L I Q + P +++G
Sbjct: 399 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEG 455
Score = 97.4 bits (241), Expect = 1e-19
Identities = 127/626 (20%), Positives = 258/626 (41%), Gaps = 97/626 (15%)
Query: 33 INKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHI 92
+N +L+ ++S IS+ P+ +H ++ F D + ++T E+ KM
Sbjct: 897 VNDTIFTNLILFFILLSSISLAAEDPV--QHTSFRNHILFYFDIVFTTIFTIEIALKMTA 954
Query: 93 RGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIR 152
G S+ ++ + + D L VS+ L F I Q S +++I R L ++R
Sbjct: 955 YGAFLHKGSFCRNYFNILD-----LLVVSVSLISFGI-----QSSAINVVKILRVLRVLR 1004
Query: 153 AFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDT 212
R R + + + + + I ++ I ++ +GVQ+F Y C + +
Sbjct: 1005 PLRAINRAKGLK-HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS-DSS 1062
Query: 213 KPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFT 272
K I T+ E++ P ++ + F+ + ++
Sbjct: 1063 KQTEAECKGNYI--TYKDGEVDHPIIQPRSWENSKFD-------------FDNVLAAMMA 1107
Query: 273 VYEAASQEGWVFLMYRAIDSFPRWRSYFY---------FITLIFFLAWLVKNVFIAVIIE 323
++ ++ EGW L+YR+IDS + Y FI I +A+ + N+F+ +I
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 324 TFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPACLQKMMRS 383
TF E Q +Q + + + + A + + P+ + + ++ S
Sbjct: 1168 TFQE---QGEQEYKNCELDKNQRQCVEYALKARPLRRYI------PKNQHQYKVWYVVNS 1218
Query: 384 SVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFT 443
+ F + ++ ++ I A +Y G++ + + + FT LF +E +LK+
Sbjct: 1219 TYFEYLMFVLILLNTICLAMQHY-GQSCLFKI-AMNILNMLFTGLFTVEMILKLIAFKPK 1276
Query: 444 GYISSSLHKFELLLVIGTTLHV----YPDLYHSQ--------------FTYFQVLRVVRL 485
Y + + F+ L+V+G+ + + H+Q T+F++ RV+RL
Sbjct: 1277 HYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRL 1336
Query: 486 IKI---SPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVE-----ELDR- 536
+K+ + ++ + L + + L + + I +Q+F + E++R
Sbjct: 1337 VKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRN 1396
Query: 537 --FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP-----------------VVAI 577
F TFP+A + +F+ T E W D+M + G AP
Sbjct: 1397 NNFQTFPQAVLLLFRCATGEAWQDIMLACMP--GKKCAPESEPSNSTEGETPCGSSFAVF 1454
Query: 578 YFILYHLFATLILLSLFVAVILDNLE 603
YFI +++ ++++LFVAVI+DN +
Sbjct: 1455 YFISFYMLCAFLIINLFVAVIMDNFD 1480
Score = 78.2 bits (191), Expect = 7e-14
Identities = 57/250 (22%), Positives = 122/250 (48%), Gaps = 17/250 (6%)
Query: 1206 ITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSP 1265
+ + F+ I L+ L + S ++ + +T T + +F E+ +K+ ++
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1266 AGFWQSRRNRYDLLVTSLGVVWVVL-HFALLNAYTYMMGACVIVFRFFSICGKHVTLKML 1324
++ S NR+D V G++ +L +++ + CV + R F I +L L
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1325 LLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFG-TVKYGENINRHANFSSAGKAITVLF 1383
+ +++ S+ +++ +FL ++ ++ G+ LFG + E R + F + +++ +F
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVF 700
Query: 1384 RIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGAL--MYFCSFYVIIAYIMLNL 1441
+I+TGEDWN +M+D ++ A ++ G L +YF ++ YI+LN+
Sbjct: 701 QILTGEDWNSVMYDGIM-------------AYGGPSFPGMLVCIYFIILFICGNYILLNV 747
Query: 1442 LVAIIVENFS 1451
+AI V+N +
Sbjct: 748 FLAIAVDNLA 757
Score = 58.9 bits (141), Expect = 4e-08
Identities = 68/287 (23%), Positives = 120/287 (41%), Gaps = 68/287 (23%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDTL---LMFLYTAEMIAKMHIRGIVKGDSSYVKD 105
+ V +NT + EHY ++T DT L+ L+TAEM+ KM+ G+ +Y
Sbjct: 531 IFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL----QAYFVS 586
Query: 106 RWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRT 165
+ FD F+V + +L +I MSP G + + R + ++R F+I R+ +
Sbjct: 587 LFNRFDCFVVCGGILETILVETKI------MSPLG-ISVLRCVRLLRIFKIT-RYWNSLS 638
Query: 166 RITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIP 225
+ L S I S+ + L F++++ +LG+Q+FG G ++ +
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFG-------------GKFNFDEM--- 682
Query: 226 DTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFL 285
+ S F+ S+ TV++ + E W +
Sbjct: 683 -------------------------------QTRRSTFDNFPQSLLTVFQILTGEDWNSV 711
Query: 286 MYRAI-----DSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAE 327
MY I SFP YFI L +++ NVF+A+ ++ A+
Sbjct: 712 MYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLAD 758
Score = 51.2 bits (121), Expect = 9e-06
Identities = 64/306 (20%), Positives = 120/306 (39%), Gaps = 62/306 (20%)
Query: 890 WVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
W++I + + +++ E + A + + E+ LK+ + GL ++
Sbjct: 528 WLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSL 587
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVP---QMRKV 1006
F D F+ ++ + + + G + VLRC+R LRIFK+ + +
Sbjct: 588 FNRF----DCFVVCGGILETILVETKIMSPLG---ISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1007 VRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVS 1066
V L + + I + +LL +++F+ G+QLF GK F +
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGK------------------FNFDE- 681
Query: 1067 VSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVR-DVII 1125
R FDN ++L +F++L+ + W V D I+
Sbjct: 682 ------------------------MQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIM 717
Query: 1126 HRVGP-----IHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKS 1180
GP + IY + G I L +F+ + + N + + LT Q+ E+ K
Sbjct: 718 AYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAES---LTSAQKEEEEEKE 774
Query: 1181 RLKIAQ 1186
R K+A+
Sbjct: 775 RKKLAR 780
Score = 41.6 bits (96), Expect = 0.007
Identities = 57/300 (19%), Positives = 110/300 (36%), Gaps = 76/300 (25%)
Query: 1212 FKRTIALLVLAQSVLLSV----KWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMS--- 1264
F+ I L + A V L++ D + L + +F IF +E +K+IA
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLF 185
Query: 1265 -PAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGA-----------CVIVFRFF 1312
P + ++ N D ++ +G+ +L A +G V R
Sbjct: 186 HPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPL 245
Query: 1313 SICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLF--------------- 1357
+ +L+++L +++ +M I + + +++ YA G+ LF
Sbjct: 246 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIA 305
Query: 1358 -----------------------GTV-KYGENINRHA--NFSSAGKAITVLFRIVTGEDW 1391
GTV K G + +H NF + A+ +F+ +T E W
Sbjct: 306 DVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGW 365
Query: 1392 NKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFS 1451
++ YW D +YF + +I ++ +LNL++ ++ FS
Sbjct: 366 TDVL----------------YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS 409
>gi|193788724 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 2 [Homo sapiens]
Length = 2186
Score = 213 bits (541), Expect = 2e-54
Identities = 188/709 (26%), Positives = 334/709 (47%), Gaps = 89/709 (12%)
Query: 921 AEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAES 980
A+YVF ++E+ LK+ A G F + R++ ++D+ + VSLI +
Sbjct: 956 ADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINV-- 1013
Query: 981 GAQLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFA 1040
++L VLR LRPLR ++ VV+ +F + I + I+ L +FA GVQLF
Sbjct: 1014 -VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFK 1072
Query: 1041 GKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDN 1100
GKL C+D + +C G + + + GE PR W N + F+FDN
Sbjct: 1073 GKLYTCSDSSKQTEAECKGNY-----------ITYKDGEVDHPIIQPRSWENSK-FDFDN 1120
Query: 1101 VGNAMLALFEVLSLKGWVEV--RDVIIHRV--GPIHG------IYIHVFVFLGCMIGLTL 1150
V AM+ALF V + +GW E+ R + H GPI+ I+ +++ + + +
Sbjct: 1121 VLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNI 1180
Query: 1151 FVGVVIANFNENKGTALLT--VDQRRWEDLKSRLKIAQPL--HLPPRPDNDGFRAKMYDI 1206
FVG VI F E +D+ + + ++ LK A+PL ++P + + K++ +
Sbjct: 1181 FVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALK-ARPLRRYIP----KNQHQYKVWYV 1235
Query: 1207 TQHPFFKRTIALLVLAQSVLLSVKWDVEDPV-TVPLATMSVVFTFIFVLEVTMKIIAMSP 1265
+F+ + +L+L ++ L+++ + + + + ++++FT +F +E+ +K+IA P
Sbjct: 1236 VNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKP 1295
Query: 1266 AGFWQSRRNRYDLLVTSLGVVWVVL----HFALLNAYTY----MMGACVIV--------- 1308
G++ N +D L+ ++ V+L H+ T+ ++G+ V +
Sbjct: 1296 KGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAE 1355
Query: 1309 --------------------FRFFSIC------GKHVTLKMLLLTVVVSMYKSFFIIVGM 1342
FR F + + ++ LL T + S ++ + +
Sbjct: 1356 HTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI 1415
Query: 1343 FLLLLCYAFAGVVLFGTVKYGEN--INRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMV 1400
+L YA G+ +FG + + INR+ NF + +A+ +LFR TGE W IM CM
Sbjct: 1416 VMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMP 1475
Query: 1401 QP---PFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTE 1457
P P T T CG+ + A+ YF SFY++ A++++NL VA+I++NF Y T
Sbjct: 1476 GKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFD--YLTR 1532
Query: 1458 EDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEV-DLDKDKLLFKHMC 1516
+ +L + L F+ IW D + +G I V LLR ++ L L ++ K +
Sbjct: 1533 DWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLV 1592
Query: 1517 YEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEE 1565
L++ G V F+ L L ++ I+ LE+ A E+L I++
Sbjct: 1593 SMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQ--ANEELRAIIKK 1639
Score = 147 bits (370), Expect = 1e-34
Identities = 149/687 (21%), Positives = 296/687 (43%), Gaps = 102/687 (14%)
Query: 74 LDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIV 133
++ L + ++T E K+ G++ ++Y+++ W + D +V V L + E A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVV---VGLFSAILEQATKA 218
Query: 134 DQMSPWGMLRIPRPLIMIRAFRIYFRFEL----PRTRIT-NILKRSGEQIWSVSIFLLFF 188
D + G + +RAFR+ L P ++ N + ++ + +++ +LF
Sbjct: 219 DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 278
Query: 189 LLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDL 248
+++Y I+G+++F + N +V P C+ E G QC G C
Sbjct: 279 IIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSP---CALETGHGRQCQNGTVCKP- 334
Query: 249 EDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFF 308
G + G + F+ ++ TV++ + EGW ++Y D+ R + YF+TLI
Sbjct: 335 ---GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIII 391
Query: 309 LAWLVKNVFIAVIIETF------AEIRVQFQQM---------------WGSRS------- 340
++ V N+ + V+ F A+ R FQ++ W +++
Sbjct: 392 GSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPEN 451
Query: 341 -------------STTSTATTQMFHEDAAGG-------WQLVAVDVNKPQGRA------P 374
S ++ T + E+ AGG +A ++K +
Sbjct: 452 EDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNR 511
Query: 375 ACLQKM---MRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDL 431
C +K ++S+VF+ ++ +V ++ + AS +Y N+ + + A A LF
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD--TANKALLALFTA 569
Query: 432 EALLKIWCLGFTGYISSSLHKFELLLVIGTTLH-------VYPDLYHSQFTYFQVLRVVR 484
E LLK++ LG Y S ++F+ +V G L + L S ++LR+ +
Sbjct: 570 EMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFK 629
Query: 485 LIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR-------F 537
+ + +L + V + + + SL++ +I+ S + +Q+F D F
Sbjct: 630 ITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTF 689
Query: 538 TTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP--VVAIYFILYHLFATLILLSLFV 595
FP++ +++FQILT E W VM + A G P +V IYFI+ + ILL++F+
Sbjct: 690 DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFL 749
Query: 596 AVILDNLELDEDLKKLKQLKQSE---------ANADTKEKLPLRLRIFEKFPNRPQMVKI 646
A+ +DNL E L ++ ++ E A+ + K++L + + E ++ + +++
Sbjct: 750 AIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE---SKEEKIEL 806
Query: 647 SKLPSDFTVPKIRESFMKQFIDRQQQD 673
+ +D P + M + +D
Sbjct: 807 KSITADGESPPATKINMDDLQPNENED 833
Score = 104 bits (260), Expect = 7e-22
Identities = 94/357 (26%), Positives = 164/357 (45%), Gaps = 62/357 (17%)
Query: 885 VTYLDW----VMIIVTI-CSCISMMFESPFRRVMHAPT---LQIAEYVFVIFMSIELNLK 936
++ ++W ++I++TI +C+++ PF T L+ EY+F+I ++E LK
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 937 IMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQL-----------L 985
++A GL F P A +R+ ++D I +V L F + Q A+ L L
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGL-FSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 986 MVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAK 1045
R LRPLR+ VP ++ V+ + + +++L+L +++++A G++LF GK+ K
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 1046 C-------------NDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWAN 1092
+DP+ E +G N +V K PG W
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCK-------PG-----------WDG 338
Query: 1093 PRN--FNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVG-PIHGIYIHVFVFLGCMIGLT 1149
P++ NFDN AML +F+ ++++GW +V + VG IY + +G L
Sbjct: 339 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLN 398
Query: 1150 LFVGVVIANFNENKGTALLTVD-------QRRWEDLKSRLK-IAQPLHLPPRPDNDG 1198
L +GV+ F++ + A D Q+ EDLK L I Q + P +++G
Sbjct: 399 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEG 455
Score = 89.0 bits (219), Expect = 4e-17
Identities = 126/612 (20%), Positives = 245/612 (40%), Gaps = 123/612 (20%)
Query: 75 DTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVD 134
D + ++T E+I KM G S+ ++ + + D L VS+ L F I
Sbjct: 957 DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILD-----LLVVSVSLISFGI----- 1006
Query: 135 QMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGI 194
Q S +++I R L ++R R R + + + + + I ++ I ++
Sbjct: 1007 QSSAINVVKILRVLRVLRPLRAINRAKGLK-HVVQCVFVAIRTIGNIVIVTTLLQFMFAC 1065
Query: 195 LGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLS 254
+GVQ+F Y C + +K I T+ E++ P ++ +
Sbjct: 1066 IGVQLFKGKLYTCS-DSSKQTEAECKGNYI--TYKDGEVDHPIIQPRSWENSKFD----- 1117
Query: 255 RQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFY---------FITL 305
F+ + ++ ++ ++ EGW L+YR+IDS + Y FI
Sbjct: 1118 --------FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIY 1169
Query: 306 IFFLAWLVKNVFIAVIIETFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVD 365
I +A+ + N+F+ +I TF E Q +Q + + + + A + +
Sbjct: 1170 IIIIAFFMMNIFVGFVIVTFQE---QGEQEYKNCELDKNQRQCVEYALKARPLRRYI--- 1223
Query: 366 VNKPQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAF 425
P+ + + ++ S+ F + ++ ++ I A +Y G++ + + + F
Sbjct: 1224 ---PKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHY-GQSCLFKI-AMNILNMLF 1278
Query: 426 TVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGT--------TLHVYPDLY------- 470
T LF +E +LK+ GY S + F+ L+VIG+ T H + D +
Sbjct: 1279 TGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALI 1338
Query: 471 -----------------HSQ--------------FTYFQVLRVVRLIKI---SPALEDFV 496
H+Q T+F++ RV+RL+K+ + +
Sbjct: 1339 VVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLL 1398
Query: 497 YKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVE-----ELDR---FTTFPRAFMSMF 548
+ + L + + L + + I +Q+F + E++R F TFP+A + +F
Sbjct: 1399 WTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLF 1458
Query: 549 QILTQEGWVDVMDQTLNAVGHMWAP-----------------VVAIYFILYHLFATLILL 591
+ T E W D+M + G AP YFI +++ +++
Sbjct: 1459 RCATGEAWQDIMLACMP--GKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLII 1516
Query: 592 SLFVAVILDNLE 603
+LFVAVI+DN +
Sbjct: 1517 NLFVAVIMDNFD 1528
Score = 78.2 bits (191), Expect = 7e-14
Identities = 57/250 (22%), Positives = 122/250 (48%), Gaps = 17/250 (6%)
Query: 1206 ITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSP 1265
+ + F+ I L+ L + S ++ + +T T + +F E+ +K+ ++
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1266 AGFWQSRRNRYDLLVTSLGVVWVVL-HFALLNAYTYMMGACVIVFRFFSICGKHVTLKML 1324
++ S NR+D V G++ +L +++ + CV + R F I +L L
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1325 LLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFG-TVKYGENINRHANFSSAGKAITVLF 1383
+ +++ S+ +++ +FL ++ ++ G+ LFG + E R + F + +++ +F
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVF 700
Query: 1384 RIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGAL--MYFCSFYVIIAYIMLNL 1441
+I+TGEDWN +M+D ++ A ++ G L +YF ++ YI+LN+
Sbjct: 701 QILTGEDWNSVMYDGIM-------------AYGGPSFPGMLVCIYFIILFICGNYILLNV 747
Query: 1442 LVAIIVENFS 1451
+AI V+N +
Sbjct: 748 FLAIAVDNLA 757
Score = 58.9 bits (141), Expect = 4e-08
Identities = 68/287 (23%), Positives = 120/287 (41%), Gaps = 68/287 (23%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDTL---LMFLYTAEMIAKMHIRGIVKGDSSYVKD 105
+ V +NT + EHY ++T DT L+ L+TAEM+ KM+ G+ +Y
Sbjct: 531 IFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL----QAYFVS 586
Query: 106 RWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRT 165
+ FD F+V + +L +I MSP G + + R + ++R F+I R+ +
Sbjct: 587 LFNRFDCFVVCGGILETILVETKI------MSPLG-ISVLRCVRLLRIFKIT-RYWNSLS 638
Query: 166 RITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIP 225
+ L S I S+ + L F++++ +LG+Q+FG G ++ +
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFG-------------GKFNFDEM--- 682
Query: 226 DTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFL 285
+ S F+ S+ TV++ + E W +
Sbjct: 683 -------------------------------QTRRSTFDNFPQSLLTVFQILTGEDWNSV 711
Query: 286 MYRAI-----DSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAE 327
MY I SFP YFI L +++ NVF+A+ ++ A+
Sbjct: 712 MYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLAD 758
Score = 51.2 bits (121), Expect = 9e-06
Identities = 64/306 (20%), Positives = 120/306 (39%), Gaps = 62/306 (20%)
Query: 890 WVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
W++I + + +++ E + A + + E+ LK+ + GL ++
Sbjct: 528 WLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSL 587
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVP---QMRKV 1006
F D F+ ++ + + + G + VLRC+R LRIFK+ + +
Sbjct: 588 FNRF----DCFVVCGGILETILVETKIMSPLG---ISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1007 VRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVS 1066
V L + + I + +LL +++F+ G+QLF GK F +
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGK------------------FNFDE- 681
Query: 1067 VSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVR-DVII 1125
R FDN ++L +F++L+ + W V D I+
Sbjct: 682 ------------------------MQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIM 717
Query: 1126 HRVGP-----IHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKS 1180
GP + IY + G I L +F+ + + N + + LT Q+ E+ K
Sbjct: 718 AYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAES---LTSAQKEEEEEKE 774
Query: 1181 RLKIAQ 1186
R K+A+
Sbjct: 775 RKKLAR 780
Score = 50.4 bits (119), Expect = 1e-05
Identities = 59/296 (19%), Positives = 122/296 (41%), Gaps = 79/296 (26%)
Query: 379 KMMRSSVFHMFILSMVTVDVI-VAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKI 437
+++ ++F IL + + I +AA + + +FR + ++ FT +F +E LKI
Sbjct: 895 RIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHI--LFYFDIVFTTIFTIEIALKI 952
Query: 438 WCLGFTGYISSSLHKFELLL---VIGTTLH---------------------VYPDLYHSQ 473
LG Y+ +S+ E++L G LH + + S
Sbjct: 953 --LGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA 1010
Query: 474 FTYFQVLRVVRL------IKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQM 527
++LRV+R+ I + L+ V +F + +G++V+ T L + + I +Q+
Sbjct: 1011 INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQL 1070
Query: 528 F------CFVE------------------ELDRFTTFPR--------------AFMSMFQ 549
F C E+D PR A M++F
Sbjct: 1071 FKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFT 1130
Query: 550 ILTQEGWVDVMDQTLNAVGHMWAPV------VAIYFILYHLFATLILLSLFVAVIL 599
+ T EGW +++ +++++ P+ ++I+FI+Y + ++++FV ++
Sbjct: 1131 VSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1186
Score = 47.0 bits (110), Expect = 2e-04
Identities = 68/318 (21%), Positives = 117/318 (36%), Gaps = 77/318 (24%)
Query: 1196 NDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVP------LATMSVVFT 1249
N+ FR + + I F I +L S+ L+ EDPV L +VFT
Sbjct: 886 NNRFRLQCHRIVNDTIFTNLILFFILLSSISLAA----EDPVQHTSFRNHILFYFDIVFT 941
Query: 1250 FIFVLEVTMKIIA------------------------MSPAGFWQSRRNRYDLLVTSLGV 1285
IF +E+ +KI+ + F ++ N DLLV S+ +
Sbjct: 942 TIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSL 1001
Query: 1286 VWVVLHFALLNAYTYMMGACVIVFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLL 1345
+ + + +N + + V R + LK ++ V V++ I++ LL
Sbjct: 1002 ISFGIQSSAINVVKIL--RVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLL 1059
Query: 1346 LLCYAFAGVVLFG----------------------TVKYGEN----------INRHANFS 1373
+A GV LF T K GE N +F
Sbjct: 1060 QFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFD 1119
Query: 1374 SAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGAL-MYFCSFYV 1432
+ A+ LF + T E W ++++ + D T NY + ++F + +
Sbjct: 1120 NVLAAMMALFTVSTFEGWPELLYRSI--------DSHTEDKGPIYNYRVEISIFFIIYII 1171
Query: 1433 IIAYIMLNLLVAIIVENF 1450
IIA+ M+N+ V ++ F
Sbjct: 1172 IIAFFMMNIFVGFVIVTF 1189
Score = 45.1 bits (105), Expect = 6e-04
Identities = 76/342 (22%), Positives = 124/342 (36%), Gaps = 99/342 (28%)
Query: 33 INKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMF---LYTAEMIAK 89
+N + L+ + +++ I + M +HY ++ L M L+T EMI K
Sbjct: 1236 VNSTYFEYLMFVLILLNTICLAM------QHYGQSCLFKIAMNILNMLFTGLFTVEMILK 1289
Query: 90 MHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQ---------------VFEIADIVD 134
+ I Y D W VFD +V + ++L + + IVD
Sbjct: 1290 L----IAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVD 1345
Query: 135 ------------QMSPWGMLRIPRPLIMIRAFRIY---------FRFELPRTRITNILKR 173
Q SP M I I FR++ R E RT + +K
Sbjct: 1346 IAITEVNPAEHTQCSP-SMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK- 1403
Query: 174 SGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDT-----H 228
S + + V++ ++ +Y ++G+Q+FG +NDT N N P
Sbjct: 1404 SFQALPYVALLIVMLFFIYAVIGMQVFGKI----ALNDTTEINRNNNFQTFPQAVLLLFR 1459
Query: 229 CSPELEEGYQ-----CPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWV 283
C+ E +Q C PG KC + S + G G+S
Sbjct: 1460 CA--TGEAWQDIMLACMPGKKCAPESEPSNSTE-----GETPCGSSF------------- 1499
Query: 284 FLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETF 325
+ FYFI+ A+L+ N+F+AVI++ F
Sbjct: 1500 --------------AVFYFISFYMLCAFLIINLFVAVIMDNF 1527
Score = 41.6 bits (96), Expect = 0.007
Identities = 57/300 (19%), Positives = 110/300 (36%), Gaps = 76/300 (25%)
Query: 1212 FKRTIALLVLAQSVLLSV----KWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMS--- 1264
F+ I L + A V L++ D + L + +F IF +E +K+IA
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLF 185
Query: 1265 -PAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGA-----------CVIVFRFF 1312
P + ++ N D ++ +G+ +L A +G V R
Sbjct: 186 HPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPL 245
Query: 1313 SICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLF--------------- 1357
+ +L+++L +++ +M I + + +++ YA G+ LF
Sbjct: 246 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIA 305
Query: 1358 -----------------------GTV-KYGENINRHA--NFSSAGKAITVLFRIVTGEDW 1391
GTV K G + +H NF + A+ +F+ +T E W
Sbjct: 306 DVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGW 365
Query: 1392 NKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFS 1451
++ YW D +YF + +I ++ +LNL++ ++ FS
Sbjct: 366 TDVL----------------YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS 409
>gi|193788720 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 1 [Homo sapiens]
Length = 2221
Score = 213 bits (541), Expect = 2e-54
Identities = 188/709 (26%), Positives = 334/709 (47%), Gaps = 89/709 (12%)
Query: 921 AEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAES 980
A+YVF ++E+ LK+ A G F + R++ ++D+ + VSLI +
Sbjct: 956 ADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINV-- 1013
Query: 981 GAQLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFA 1040
++L VLR LRPLR ++ VV+ +F + I + I+ L +FA GVQLF
Sbjct: 1014 -VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFK 1072
Query: 1041 GKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDN 1100
GKL C+D + +C G + + + GE PR W N + F+FDN
Sbjct: 1073 GKLYTCSDSSKQTEAECKGNY-----------ITYKDGEVDHPIIQPRSWENSK-FDFDN 1120
Query: 1101 VGNAMLALFEVLSLKGWVEV--RDVIIHRV--GPIHG------IYIHVFVFLGCMIGLTL 1150
V AM+ALF V + +GW E+ R + H GPI+ I+ +++ + + +
Sbjct: 1121 VLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNI 1180
Query: 1151 FVGVVIANFNENKGTALLT--VDQRRWEDLKSRLKIAQPL--HLPPRPDNDGFRAKMYDI 1206
FVG VI F E +D+ + + ++ LK A+PL ++P + + K++ +
Sbjct: 1181 FVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALK-ARPLRRYIP----KNQHQYKVWYV 1235
Query: 1207 TQHPFFKRTIALLVLAQSVLLSVKWDVEDPV-TVPLATMSVVFTFIFVLEVTMKIIAMSP 1265
+F+ + +L+L ++ L+++ + + + + ++++FT +F +E+ +K+IA P
Sbjct: 1236 VNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKP 1295
Query: 1266 AGFWQSRRNRYDLLVTSLGVVWVVL----HFALLNAYTY----MMGACVIV--------- 1308
G++ N +D L+ ++ V+L H+ T+ ++G+ V +
Sbjct: 1296 KGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAE 1355
Query: 1309 --------------------FRFFSIC------GKHVTLKMLLLTVVVSMYKSFFIIVGM 1342
FR F + + ++ LL T + S ++ + +
Sbjct: 1356 HTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI 1415
Query: 1343 FLLLLCYAFAGVVLFGTVKYGEN--INRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMV 1400
+L YA G+ +FG + + INR+ NF + +A+ +LFR TGE W IM CM
Sbjct: 1416 VMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMP 1475
Query: 1401 QP---PFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTE 1457
P P T T CG+ + A+ YF SFY++ A++++NL VA+I++NF Y T
Sbjct: 1476 GKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFD--YLTR 1532
Query: 1458 EDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEV-DLDKDKLLFKHMC 1516
+ +L + L F+ IW D + +G I V LLR ++ L L ++ K +
Sbjct: 1533 DWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLV 1592
Query: 1517 YEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEE 1565
L++ G V F+ L L ++ I+ LE+ A E+L I++
Sbjct: 1593 SMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQ--ANEELRAIIKK 1639
Score = 147 bits (370), Expect = 1e-34
Identities = 149/687 (21%), Positives = 296/687 (43%), Gaps = 102/687 (14%)
Query: 74 LDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIV 133
++ L + ++T E K+ G++ ++Y+++ W + D +V V L + E A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVV---VGLFSAILEQATKA 218
Query: 134 DQMSPWGMLRIPRPLIMIRAFRIYFRFEL----PRTRIT-NILKRSGEQIWSVSIFLLFF 188
D + G + +RAFR+ L P ++ N + ++ + +++ +LF
Sbjct: 219 DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 278
Query: 189 LLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDL 248
+++Y I+G+++F + N +V P C+ E G QC G C
Sbjct: 279 IIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSP---CALETGHGRQCQNGTVCKP- 334
Query: 249 EDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFF 308
G + G + F+ ++ TV++ + EGW ++Y D+ R + YF+TLI
Sbjct: 335 ---GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIII 391
Query: 309 LAWLVKNVFIAVIIETF------AEIRVQFQQM---------------WGSRS------- 340
++ V N+ + V+ F A+ R FQ++ W +++
Sbjct: 392 GSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPEN 451
Query: 341 -------------STTSTATTQMFHEDAAGG-------WQLVAVDVNKPQGRA------P 374
S ++ T + E+ AGG +A ++K +
Sbjct: 452 EDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNR 511
Query: 375 ACLQKM---MRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDL 431
C +K ++S+VF+ ++ +V ++ + AS +Y N+ + + A A LF
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD--TANKALLALFTA 569
Query: 432 EALLKIWCLGFTGYISSSLHKFELLLVIGTTLH-------VYPDLYHSQFTYFQVLRVVR 484
E LLK++ LG Y S ++F+ +V G L + L S ++LR+ +
Sbjct: 570 EMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFK 629
Query: 485 LIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR-------F 537
+ + +L + V + + + SL++ +I+ S + +Q+F D F
Sbjct: 630 ITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTF 689
Query: 538 TTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP--VVAIYFILYHLFATLILLSLFV 595
FP++ +++FQILT E W VM + A G P +V IYFI+ + ILL++F+
Sbjct: 690 DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFL 749
Query: 596 AVILDNLELDEDLKKLKQLKQSE---------ANADTKEKLPLRLRIFEKFPNRPQMVKI 646
A+ +DNL E L ++ ++ E A+ + K++L + + E ++ + +++
Sbjct: 750 AIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE---SKEEKIEL 806
Query: 647 SKLPSDFTVPKIRESFMKQFIDRQQQD 673
+ +D P + M + +D
Sbjct: 807 KSITADGESPPATKINMDDLQPNENED 833
Score = 104 bits (260), Expect = 7e-22
Identities = 94/357 (26%), Positives = 164/357 (45%), Gaps = 62/357 (17%)
Query: 885 VTYLDW----VMIIVTI-CSCISMMFESPFRRVMHAPT---LQIAEYVFVIFMSIELNLK 936
++ ++W ++I++TI +C+++ PF T L+ EY+F+I ++E LK
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 937 IMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQL-----------L 985
++A GL F P A +R+ ++D I +V L F + Q A+ L L
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGL-FSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 986 MVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAK 1045
R LRPLR+ VP ++ V+ + + +++L+L +++++A G++LF GK+ K
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 1046 C-------------NDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWAN 1092
+DP+ E +G N +V K PG W
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCK-------PG-----------WDG 338
Query: 1093 PRN--FNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVG-PIHGIYIHVFVFLGCMIGLT 1149
P++ NFDN AML +F+ ++++GW +V + VG IY + +G L
Sbjct: 339 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLN 398
Query: 1150 LFVGVVIANFNENKGTALLTVD-------QRRWEDLKSRLK-IAQPLHLPPRPDNDG 1198
L +GV+ F++ + A D Q+ EDLK L I Q + P +++G
Sbjct: 399 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEG 455
Score = 89.0 bits (219), Expect = 4e-17
Identities = 126/612 (20%), Positives = 245/612 (40%), Gaps = 123/612 (20%)
Query: 75 DTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVD 134
D + ++T E+I KM G S+ ++ + + D L VS+ L F I
Sbjct: 957 DYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILD-----LLVVSVSLISFGI----- 1006
Query: 135 QMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGI 194
Q S +++I R L ++R R R + + + + + I ++ I ++
Sbjct: 1007 QSSAINVVKILRVLRVLRPLRAINRAKGLK-HVVQCVFVAIRTIGNIVIVTTLLQFMFAC 1065
Query: 195 LGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLS 254
+GVQ+F Y C + +K I T+ E++ P ++ +
Sbjct: 1066 IGVQLFKGKLYTCS-DSSKQTEAECKGNYI--TYKDGEVDHPIIQPRSWENSKFD----- 1117
Query: 255 RQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFY---------FITL 305
F+ + ++ ++ ++ EGW L+YR+IDS + Y FI
Sbjct: 1118 --------FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIY 1169
Query: 306 IFFLAWLVKNVFIAVIIETFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVD 365
I +A+ + N+F+ +I TF E Q +Q + + + + A + +
Sbjct: 1170 IIIIAFFMMNIFVGFVIVTFQE---QGEQEYKNCELDKNQRQCVEYALKARPLRRYI--- 1223
Query: 366 VNKPQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAF 425
P+ + + ++ S+ F + ++ ++ I A +Y G++ + + + F
Sbjct: 1224 ---PKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHY-GQSCLFKI-AMNILNMLF 1278
Query: 426 TVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGT--------TLHVYPDLY------- 470
T LF +E +LK+ GY S + F+ L+VIG+ T H + D +
Sbjct: 1279 TGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALI 1338
Query: 471 -----------------HSQ--------------FTYFQVLRVVRLIKI---SPALEDFV 496
H+Q T+F++ RV+RL+K+ + +
Sbjct: 1339 VVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLL 1398
Query: 497 YKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVE-----ELDR---FTTFPRAFMSMF 548
+ + L + + L + + I +Q+F + E++R F TFP+A + +F
Sbjct: 1399 WTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLF 1458
Query: 549 QILTQEGWVDVMDQTLNAVGHMWAP-----------------VVAIYFILYHLFATLILL 591
+ T E W D+M + G AP YFI +++ +++
Sbjct: 1459 RCATGEAWQDIMLACMP--GKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLII 1516
Query: 592 SLFVAVILDNLE 603
+LFVAVI+DN +
Sbjct: 1517 NLFVAVIMDNFD 1528
Score = 78.2 bits (191), Expect = 7e-14
Identities = 57/250 (22%), Positives = 122/250 (48%), Gaps = 17/250 (6%)
Query: 1206 ITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSP 1265
+ + F+ I L+ L + S ++ + +T T + +F E+ +K+ ++
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1266 AGFWQSRRNRYDLLVTSLGVVWVVL-HFALLNAYTYMMGACVIVFRFFSICGKHVTLKML 1324
++ S NR+D V G++ +L +++ + CV + R F I +L L
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1325 LLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFG-TVKYGENINRHANFSSAGKAITVLF 1383
+ +++ S+ +++ +FL ++ ++ G+ LFG + E R + F + +++ +F
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVF 700
Query: 1384 RIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGAL--MYFCSFYVIIAYIMLNL 1441
+I+TGEDWN +M+D ++ A ++ G L +YF ++ YI+LN+
Sbjct: 701 QILTGEDWNSVMYDGIM-------------AYGGPSFPGMLVCIYFIILFICGNYILLNV 747
Query: 1442 LVAIIVENFS 1451
+AI V+N +
Sbjct: 748 FLAIAVDNLA 757
Score = 58.9 bits (141), Expect = 4e-08
Identities = 68/287 (23%), Positives = 120/287 (41%), Gaps = 68/287 (23%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDTL---LMFLYTAEMIAKMHIRGIVKGDSSYVKD 105
+ V +NT + EHY ++T DT L+ L+TAEM+ KM+ G+ +Y
Sbjct: 531 IFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL----QAYFVS 586
Query: 106 RWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRT 165
+ FD F+V + +L +I MSP G + + R + ++R F+I R+ +
Sbjct: 587 LFNRFDCFVVCGGILETILVETKI------MSPLG-ISVLRCVRLLRIFKIT-RYWNSLS 638
Query: 166 RITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIP 225
+ L S I S+ + L F++++ +LG+Q+FG G ++ +
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFG-------------GKFNFDEM--- 682
Query: 226 DTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFL 285
+ S F+ S+ TV++ + E W +
Sbjct: 683 -------------------------------QTRRSTFDNFPQSLLTVFQILTGEDWNSV 711
Query: 286 MYRAI-----DSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAE 327
MY I SFP YFI L +++ NVF+A+ ++ A+
Sbjct: 712 MYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLAD 758
Score = 51.2 bits (121), Expect = 9e-06
Identities = 64/306 (20%), Positives = 120/306 (39%), Gaps = 62/306 (20%)
Query: 890 WVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
W++I + + +++ E + A + + E+ LK+ + GL ++
Sbjct: 528 WLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSL 587
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVP---QMRKV 1006
F D F+ ++ + + + G + VLRC+R LRIFK+ + +
Sbjct: 588 FNRF----DCFVVCGGILETILVETKIMSPLG---ISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1007 VRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVS 1066
V L + + I + +LL +++F+ G+QLF GK F +
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGK------------------FNFDE- 681
Query: 1067 VSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVR-DVII 1125
R FDN ++L +F++L+ + W V D I+
Sbjct: 682 ------------------------MQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIM 717
Query: 1126 HRVGP-----IHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKS 1180
GP + IY + G I L +F+ + + N + + LT Q+ E+ K
Sbjct: 718 AYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAES---LTSAQKEEEEEKE 774
Query: 1181 RLKIAQ 1186
R K+A+
Sbjct: 775 RKKLAR 780
Score = 50.4 bits (119), Expect = 1e-05
Identities = 59/296 (19%), Positives = 122/296 (41%), Gaps = 79/296 (26%)
Query: 379 KMMRSSVFHMFILSMVTVDVI-VAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKI 437
+++ ++F IL + + I +AA + + +FR + ++ FT +F +E LKI
Sbjct: 895 RIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHI--LFYFDIVFTTIFTIEIALKI 952
Query: 438 WCLGFTGYISSSLHKFELLL---VIGTTLH---------------------VYPDLYHSQ 473
LG Y+ +S+ E++L G LH + + S
Sbjct: 953 --LGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSA 1010
Query: 474 FTYFQVLRVVRL------IKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQM 527
++LRV+R+ I + L+ V +F + +G++V+ T L + + I +Q+
Sbjct: 1011 INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQL 1070
Query: 528 F------CFVE------------------ELDRFTTFPR--------------AFMSMFQ 549
F C E+D PR A M++F
Sbjct: 1071 FKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFT 1130
Query: 550 ILTQEGWVDVMDQTLNAVGHMWAPV------VAIYFILYHLFATLILLSLFVAVIL 599
+ T EGW +++ +++++ P+ ++I+FI+Y + ++++FV ++
Sbjct: 1131 VSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1186
Score = 47.0 bits (110), Expect = 2e-04
Identities = 68/318 (21%), Positives = 117/318 (36%), Gaps = 77/318 (24%)
Query: 1196 NDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVP------LATMSVVFT 1249
N+ FR + + I F I +L S+ L+ EDPV L +VFT
Sbjct: 886 NNRFRLQCHRIVNDTIFTNLILFFILLSSISLAA----EDPVQHTSFRNHILFYFDIVFT 941
Query: 1250 FIFVLEVTMKIIA------------------------MSPAGFWQSRRNRYDLLVTSLGV 1285
IF +E+ +KI+ + F ++ N DLLV S+ +
Sbjct: 942 TIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSL 1001
Query: 1286 VWVVLHFALLNAYTYMMGACVIVFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLL 1345
+ + + +N + + V R + LK ++ V V++ I++ LL
Sbjct: 1002 ISFGIQSSAINVVKIL--RVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLL 1059
Query: 1346 LLCYAFAGVVLFG----------------------TVKYGEN----------INRHANFS 1373
+A GV LF T K GE N +F
Sbjct: 1060 QFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFD 1119
Query: 1374 SAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGAL-MYFCSFYV 1432
+ A+ LF + T E W ++++ + D T NY + ++F + +
Sbjct: 1120 NVLAAMMALFTVSTFEGWPELLYRSI--------DSHTEDKGPIYNYRVEISIFFIIYII 1171
Query: 1433 IIAYIMLNLLVAIIVENF 1450
IIA+ M+N+ V ++ F
Sbjct: 1172 IIAFFMMNIFVGFVIVTF 1189
Score = 45.1 bits (105), Expect = 6e-04
Identities = 76/342 (22%), Positives = 124/342 (36%), Gaps = 99/342 (28%)
Query: 33 INKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMF---LYTAEMIAK 89
+N + L+ + +++ I + M +HY ++ L M L+T EMI K
Sbjct: 1236 VNSTYFEYLMFVLILLNTICLAM------QHYGQSCLFKIAMNILNMLFTGLFTVEMILK 1289
Query: 90 MHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQ---------------VFEIADIVD 134
+ I Y D W VFD +V + ++L + + IVD
Sbjct: 1290 L----IAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVD 1345
Query: 135 ------------QMSPWGMLRIPRPLIMIRAFRIY---------FRFELPRTRITNILKR 173
Q SP M I I FR++ R E RT + +K
Sbjct: 1346 IAITEVNPAEHTQCSP-SMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIK- 1403
Query: 174 SGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDT-----H 228
S + + V++ ++ +Y ++G+Q+FG +NDT N N P
Sbjct: 1404 SFQALPYVALLIVMLFFIYAVIGMQVFGKI----ALNDTTEINRNNNFQTFPQAVLLLFR 1459
Query: 229 CSPELEEGYQ-----CPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWV 283
C+ E +Q C PG KC + S + G G+S
Sbjct: 1460 CA--TGEAWQDIMLACMPGKKCAPESEPSNSTE-----GETPCGSSF------------- 1499
Query: 284 FLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETF 325
+ FYFI+ A+L+ N+F+AVI++ F
Sbjct: 1500 --------------AVFYFISFYMLCAFLIINLFVAVIMDNF 1527
Score = 41.6 bits (96), Expect = 0.007
Identities = 57/300 (19%), Positives = 110/300 (36%), Gaps = 76/300 (25%)
Query: 1212 FKRTIALLVLAQSVLLSV----KWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMS--- 1264
F+ I L + A V L++ D + L + +F IF +E +K+IA
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLF 185
Query: 1265 -PAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGA-----------CVIVFRFF 1312
P + ++ N D ++ +G+ +L A +G V R
Sbjct: 186 HPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPL 245
Query: 1313 SICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLF--------------- 1357
+ +L+++L +++ +M I + + +++ YA G+ LF
Sbjct: 246 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIA 305
Query: 1358 -----------------------GTV-KYGENINRHA--NFSSAGKAITVLFRIVTGEDW 1391
GTV K G + +H NF + A+ +F+ +T E W
Sbjct: 306 DVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGW 365
Query: 1392 NKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFS 1451
++ YW D +YF + +I ++ +LNL++ ++ FS
Sbjct: 366 TDVL----------------YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS 409
>gi|193788528 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 8 [Homo sapiens]
Length = 2157
Score = 213 bits (541), Expect = 2e-54
Identities = 192/737 (26%), Positives = 340/737 (46%), Gaps = 64/737 (8%)
Query: 891 VMIIVTICSCISMMFESPFRRV-MHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
+++ + S IS+ E P + L + VF +IE+ LK+ A G F +
Sbjct: 905 LILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSF 964
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRE 1009
R++ ++D+ + VSLI + ++L VLR LRPLR ++ VV+
Sbjct: 965 CRNYFNILDLLVVSVSLISFGIQSSAINV---VKILRVLRVLRPLRAINRAKGLKHVVQC 1021
Query: 1010 LFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSK 1069
+F + I + I+ L +FA GVQLF GKL C+D + +C G +
Sbjct: 1022 VFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNY-------- 1073
Query: 1070 NLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEV--RDVIIHR 1127
+ + GE PR W N + F+FDNV AM+ALF V + +GW E+ R + H
Sbjct: 1074 ---ITYKDGEVDHPIIQPRSWENSK-FDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHT 1129
Query: 1128 --VGPIH------GIYIHVFVFLGCMIGLTLFVGVVIANFNE--NKGTALLTVDQRRWED 1177
GPI+ I+ +++ + + +FVG VI F E + +D+ + +
Sbjct: 1130 EDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQC 1189
Query: 1178 LKSRLKIAQPL--HLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVK-WDVE 1234
++ LK A+PL ++P + + K++ + +F+ + +L+L ++ L+++ +
Sbjct: 1190 VEYALK-ARPLRRYIP----KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQS 1244
Query: 1235 DPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFAL 1294
+ + ++++FT +F +E+ +K+IA P ++ N +D L+ +V + +
Sbjct: 1245 CLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVN 1304
Query: 1295 LNAYTYMMGA---------CVIVFRFF------SICGKHVTLKMLLLTVVVSMYKSFFII 1339
+T + + FR F + + ++ LL T + S ++
Sbjct: 1305 PAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVA 1364
Query: 1340 VGMFLLLLCYAFAGVVLFGTVKYGE--NINRHANFSSAGKAITVLFRIVTGEDWNKIMHD 1397
+ + +L YA G+ +FG + + INR+ NF + +A+ +LFR TGE W IM
Sbjct: 1365 LLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLA 1424
Query: 1398 CMVQ---PPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFY 1454
CM P P T T CG+ + A+ YF SFY++ A++++NL VA+I++NF Y
Sbjct: 1425 CMPGKKCAPESEPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFD--Y 1481
Query: 1455 STEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEV-DLDKDKLLFK 1513
T + +L + L F+ IW D + +G I V LLR ++ L L ++ K
Sbjct: 1482 LTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACK 1541
Query: 1514 HMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEE----EVAK 1569
+ L++ G V F+ L L ++ I+ A + E E A
Sbjct: 1542 RLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQAN 1601
Query: 1570 QTIRMWLKKCLKRIRAK 1586
+ +R +KK KR K
Sbjct: 1602 EELRAIIKKIWKRTSMK 1618
Score = 147 bits (370), Expect = 1e-34
Identities = 149/687 (21%), Positives = 296/687 (43%), Gaps = 102/687 (14%)
Query: 74 LDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIV 133
++ L + ++T E K+ G++ ++Y+++ W + D +V V L + E A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVV---VGLFSAILEQATKA 218
Query: 134 DQMSPWGMLRIPRPLIMIRAFRIYFRFEL----PRTRIT-NILKRSGEQIWSVSIFLLFF 188
D + G + +RAFR+ L P ++ N + ++ + +++ +LF
Sbjct: 219 DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 278
Query: 189 LLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDL 248
+++Y I+G+++F + N +V P C+ E G QC G C
Sbjct: 279 IIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSP---CALETGHGRQCQNGTVCKP- 334
Query: 249 EDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFF 308
G + G + F+ ++ TV++ + EGW ++Y D+ R + YF+TLI
Sbjct: 335 ---GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIII 391
Query: 309 LAWLVKNVFIAVIIETF------AEIRVQFQQM---------------WGSRS------- 340
++ V N+ + V+ F A+ R FQ++ W +++
Sbjct: 392 GSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPEN 451
Query: 341 -------------STTSTATTQMFHEDAAGG-------WQLVAVDVNKPQGRA------P 374
S ++ T + E+ AGG +A ++K +
Sbjct: 452 EDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNR 511
Query: 375 ACLQKM---MRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDL 431
C +K ++S+VF+ ++ +V ++ + AS +Y N+ + + A A LF
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD--TANKALLALFTA 569
Query: 432 EALLKIWCLGFTGYISSSLHKFELLLVIGTTLH-------VYPDLYHSQFTYFQVLRVVR 484
E LLK++ LG Y S ++F+ +V G L + L S ++LR+ +
Sbjct: 570 EMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFK 629
Query: 485 LIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR-------F 537
+ + +L + V + + + SL++ +I+ S + +Q+F D F
Sbjct: 630 ITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTF 689
Query: 538 TTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP--VVAIYFILYHLFATLILLSLFV 595
FP++ +++FQILT E W VM + A G P +V IYFI+ + ILL++F+
Sbjct: 690 DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFL 749
Query: 596 AVILDNLELDEDLKKLKQLKQSE---------ANADTKEKLPLRLRIFEKFPNRPQMVKI 646
A+ +DNL E L ++ ++ E A+ + K++L + + E ++ + +++
Sbjct: 750 AIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE---SKEEKIEL 806
Query: 647 SKLPSDFTVPKIRESFMKQFIDRQQQD 673
+ +D P + M + +D
Sbjct: 807 KSITADGESPPATKINMDDLQPNENED 833
Score = 104 bits (260), Expect = 7e-22
Identities = 94/357 (26%), Positives = 164/357 (45%), Gaps = 62/357 (17%)
Query: 885 VTYLDW----VMIIVTI-CSCISMMFESPFRRVMHAPT---LQIAEYVFVIFMSIELNLK 936
++ ++W ++I++TI +C+++ PF T L+ EY+F+I ++E LK
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 937 IMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQL-----------L 985
++A GL F P A +R+ ++D I +V L F + Q A+ L L
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGL-FSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 986 MVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAK 1045
R LRPLR+ VP ++ V+ + + +++L+L +++++A G++LF GK+ K
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 1046 C-------------NDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWAN 1092
+DP+ E +G N +V K PG W
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCK-------PG-----------WDG 338
Query: 1093 PRN--FNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVG-PIHGIYIHVFVFLGCMIGLT 1149
P++ NFDN AML +F+ ++++GW +V + VG IY + +G L
Sbjct: 339 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLN 398
Query: 1150 LFVGVVIANFNENKGTALLTVD-------QRRWEDLKSRLK-IAQPLHLPPRPDNDG 1198
L +GV+ F++ + A D Q+ EDLK L I Q + P +++G
Sbjct: 399 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEG 455
Score = 97.4 bits (241), Expect = 1e-19
Identities = 127/626 (20%), Positives = 258/626 (41%), Gaps = 97/626 (15%)
Query: 33 INKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHI 92
+N +L+ ++S IS+ P+ +H ++ F D + ++T E+ KM
Sbjct: 897 VNDTIFTNLILFFILLSSISLAAEDPV--QHTSFRNHILFYFDIVFTTIFTIEIALKMTA 954
Query: 93 RGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIR 152
G S+ ++ + + D L VS+ L F I Q S +++I R L ++R
Sbjct: 955 YGAFLHKGSFCRNYFNILD-----LLVVSVSLISFGI-----QSSAINVVKILRVLRVLR 1004
Query: 153 AFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDT 212
R R + + + + + I ++ I ++ +GVQ+F Y C + +
Sbjct: 1005 PLRAINRAKGLK-HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS-DSS 1062
Query: 213 KPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFT 272
K I T+ E++ P ++ + F+ + ++
Sbjct: 1063 KQTEAECKGNYI--TYKDGEVDHPIIQPRSWENSKFD-------------FDNVLAAMMA 1107
Query: 273 VYEAASQEGWVFLMYRAIDSFPRWRSYFY---------FITLIFFLAWLVKNVFIAVIIE 323
++ ++ EGW L+YR+IDS + Y FI I +A+ + N+F+ +I
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 324 TFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPACLQKMMRS 383
TF E Q +Q + + + + A + + P+ + + ++ S
Sbjct: 1168 TFQE---QGEQEYKNCELDKNQRQCVEYALKARPLRRYI------PKNQHQYKVWYVVNS 1218
Query: 384 SVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFT 443
+ F + ++ ++ I A +Y G++ + + + FT LF +E +LK+
Sbjct: 1219 TYFEYLMFVLILLNTICLAMQHY-GQSCLFKI-AMNILNMLFTGLFTVEMILKLIAFKPK 1276
Query: 444 GYISSSLHKFELLLVIGTTLHV----YPDLYHSQ--------------FTYFQVLRVVRL 485
Y + + F+ L+V+G+ + + H+Q T+F++ RV+RL
Sbjct: 1277 HYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRL 1336
Query: 486 IKI---SPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVE-----ELDR- 536
+K+ + ++ + L + + L + + I +Q+F + E++R
Sbjct: 1337 VKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRN 1396
Query: 537 --FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP-----------------VVAI 577
F TFP+A + +F+ T E W D+M + G AP
Sbjct: 1397 NNFQTFPQAVLLLFRCATGEAWQDIMLACMP--GKKCAPESEPSNSTEGETPCGSSFAVF 1454
Query: 578 YFILYHLFATLILLSLFVAVILDNLE 603
YFI +++ ++++LFVAVI+DN +
Sbjct: 1455 YFISFYMLCAFLIINLFVAVIMDNFD 1480
Score = 78.2 bits (191), Expect = 7e-14
Identities = 57/250 (22%), Positives = 122/250 (48%), Gaps = 17/250 (6%)
Query: 1206 ITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSP 1265
+ + F+ I L+ L + S ++ + +T T + +F E+ +K+ ++
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1266 AGFWQSRRNRYDLLVTSLGVVWVVL-HFALLNAYTYMMGACVIVFRFFSICGKHVTLKML 1324
++ S NR+D V G++ +L +++ + CV + R F I +L L
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1325 LLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFG-TVKYGENINRHANFSSAGKAITVLF 1383
+ +++ S+ +++ +FL ++ ++ G+ LFG + E R + F + +++ +F
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVF 700
Query: 1384 RIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGAL--MYFCSFYVIIAYIMLNL 1441
+I+TGEDWN +M+D ++ A ++ G L +YF ++ YI+LN+
Sbjct: 701 QILTGEDWNSVMYDGIM-------------AYGGPSFPGMLVCIYFIILFICGNYILLNV 747
Query: 1442 LVAIIVENFS 1451
+AI V+N +
Sbjct: 748 FLAIAVDNLA 757
Score = 58.9 bits (141), Expect = 4e-08
Identities = 68/287 (23%), Positives = 120/287 (41%), Gaps = 68/287 (23%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDTL---LMFLYTAEMIAKMHIRGIVKGDSSYVKD 105
+ V +NT + EHY ++T DT L+ L+TAEM+ KM+ G+ +Y
Sbjct: 531 IFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL----QAYFVS 586
Query: 106 RWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRT 165
+ FD F+V + +L +I MSP G + + R + ++R F+I R+ +
Sbjct: 587 LFNRFDCFVVCGGILETILVETKI------MSPLG-ISVLRCVRLLRIFKIT-RYWNSLS 638
Query: 166 RITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIP 225
+ L S I S+ + L F++++ +LG+Q+FG G ++ +
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFG-------------GKFNFDEM--- 682
Query: 226 DTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFL 285
+ S F+ S+ TV++ + E W +
Sbjct: 683 -------------------------------QTRRSTFDNFPQSLLTVFQILTGEDWNSV 711
Query: 286 MYRAI-----DSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAE 327
MY I SFP YFI L +++ NVF+A+ ++ A+
Sbjct: 712 MYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLAD 758
Score = 51.2 bits (121), Expect = 9e-06
Identities = 64/306 (20%), Positives = 120/306 (39%), Gaps = 62/306 (20%)
Query: 890 WVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
W++I + + +++ E + A + + E+ LK+ + GL ++
Sbjct: 528 WLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSL 587
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVP---QMRKV 1006
F D F+ ++ + + + G + VLRC+R LRIFK+ + +
Sbjct: 588 FNRF----DCFVVCGGILETILVETKIMSPLG---ISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1007 VRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVS 1066
V L + + I + +LL +++F+ G+QLF GK F +
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGK------------------FNFDE- 681
Query: 1067 VSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVR-DVII 1125
R FDN ++L +F++L+ + W V D I+
Sbjct: 682 ------------------------MQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIM 717
Query: 1126 HRVGP-----IHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKS 1180
GP + IY + G I L +F+ + + N + + LT Q+ E+ K
Sbjct: 718 AYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAES---LTSAQKEEEEEKE 774
Query: 1181 RLKIAQ 1186
R K+A+
Sbjct: 775 RKKLAR 780
Score = 41.6 bits (96), Expect = 0.007
Identities = 57/300 (19%), Positives = 110/300 (36%), Gaps = 76/300 (25%)
Query: 1212 FKRTIALLVLAQSVLLSV----KWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMS--- 1264
F+ I L + A V L++ D + L + +F IF +E +K+IA
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLF 185
Query: 1265 -PAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGA-----------CVIVFRFF 1312
P + ++ N D ++ +G+ +L A +G V R
Sbjct: 186 HPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPL 245
Query: 1313 SICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLF--------------- 1357
+ +L+++L +++ +M I + + +++ YA G+ LF
Sbjct: 246 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIA 305
Query: 1358 -----------------------GTV-KYGENINRHA--NFSSAGKAITVLFRIVTGEDW 1391
GTV K G + +H NF + A+ +F+ +T E W
Sbjct: 306 DVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGW 365
Query: 1392 NKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFS 1451
++ YW D +YF + +I ++ +LNL++ ++ FS
Sbjct: 366 TDVL----------------YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS 409
>gi|193788732 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 5 [Homo sapiens]
Length = 2166
Score = 212 bits (539), Expect = 3e-54
Identities = 193/740 (26%), Positives = 344/740 (46%), Gaps = 90/740 (12%)
Query: 891 VMIIVTICSCISMMFESPFRRV-MHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
+++ + S IS+ E P + L + VF +IE+ LK+ A G F +
Sbjct: 905 LILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSF 964
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRE 1009
R++ ++D+ + VSLI + ++L VLR LRPLR ++ VV+
Sbjct: 965 CRNYFNILDLLVVSVSLISFGIQSSAINV---VKILRVLRVLRPLRAINRAKGLKHVVQC 1021
Query: 1010 LFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSK 1069
+F + I + I+ L +FA GVQLF GKL C+D + +C G +
Sbjct: 1022 VFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNY-------- 1073
Query: 1070 NLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEV--RDVIIHR 1127
+ + GE PR W N + F+FDNV AM+ALF V + +GW E+ R + H
Sbjct: 1074 ---ITYKDGEVDHPIIQPRSWENSK-FDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHT 1129
Query: 1128 V--GPIHG------IYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLT--VDQRRWED 1177
GPI+ I+ +++ + + +FVG VI F E +D+ + +
Sbjct: 1130 EDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQC 1189
Query: 1178 LKSRLKIAQPL--HLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVED 1235
++ LK A+PL ++P + + K++ + +F+ + +L+L ++ L+++ +
Sbjct: 1190 VEYALK-ARPLRRYIP----KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQS 1244
Query: 1236 PV-TVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVL---- 1290
+ + + ++++FT +F +E+ +K+IA P G++ N +D L+ ++ V+L
Sbjct: 1245 CLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETN 1304
Query: 1291 HFALLNAYTY----MMGACVIV-----------------------------FRFFSIC-- 1315
H+ T+ ++G+ V + FR F +
Sbjct: 1305 HYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRL 1364
Query: 1316 ----GKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGEN--INRH 1369
+ ++ LL T + S ++ + + +L YA G+ +FG + + INR+
Sbjct: 1365 VKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRN 1424
Query: 1370 ANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQP---PFCTPDEFTYWATDCGNYAGALMY 1426
NF + +A+ +LFR TGE W IM CM P P T T CG+ + A+ Y
Sbjct: 1425 NNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGS-SFAVFY 1483
Query: 1427 FCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIP 1486
F SFY++ A++++NL VA+I++NF Y T + +L + L F+ IW D + +G I
Sbjct: 1484 FISFYMLCAFLIINLFVAVIMDNFD--YLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIK 1541
Query: 1487 TFRVKFLLRLLRGRLEV-DLDKDKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVDIR 1545
V LLR ++ L L ++ K + L++ G V F+ L L ++ I+
Sbjct: 1542 HLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIK 1601
Query: 1546 KSLQLEELLAREQLEYTIEE 1565
LE+ A E+L I++
Sbjct: 1602 TEGNLEQ--ANEELRAIIKK 1619
Score = 147 bits (370), Expect = 1e-34
Identities = 149/687 (21%), Positives = 296/687 (43%), Gaps = 102/687 (14%)
Query: 74 LDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIV 133
++ L + ++T E K+ G++ ++Y+++ W + D +V V L + E A
Sbjct: 162 VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVV---VGLFSAILEQATKA 218
Query: 134 DQMSPWGMLRIPRPLIMIRAFRIYFRFEL----PRTRIT-NILKRSGEQIWSVSIFLLFF 188
D + G + +RAFR+ L P ++ N + ++ + +++ +LF
Sbjct: 219 DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 278
Query: 189 LLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDL 248
+++Y I+G+++F + N +V P C+ E G QC G C
Sbjct: 279 IIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSP---CALETGHGRQCQNGTVCKP- 334
Query: 249 EDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFF 308
G + G + F+ ++ TV++ + EGW ++Y D+ R + YF+TLI
Sbjct: 335 ---GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIII 391
Query: 309 LAWLVKNVFIAVIIETF------AEIRVQFQQM---------------WGSRS------- 340
++ V N+ + V+ F A+ R FQ++ W +++
Sbjct: 392 GSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPEN 451
Query: 341 -------------STTSTATTQMFHEDAAGG-------WQLVAVDVNKPQGRA------P 374
S ++ T + E+ AGG +A ++K +
Sbjct: 452 EDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNR 511
Query: 375 ACLQKM---MRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDL 431
C +K ++S+VF+ ++ +V ++ + AS +Y N+ + + A A LF
Sbjct: 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD--TANKALLALFTA 569
Query: 432 EALLKIWCLGFTGYISSSLHKFELLLVIGTTLH-------VYPDLYHSQFTYFQVLRVVR 484
E LLK++ LG Y S ++F+ +V G L + L S ++LR+ +
Sbjct: 570 EMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFK 629
Query: 485 LIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR-------F 537
+ + +L + V + + + SL++ +I+ S + +Q+F D F
Sbjct: 630 ITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTF 689
Query: 538 TTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAP--VVAIYFILYHLFATLILLSLFV 595
FP++ +++FQILT E W VM + A G P +V IYFI+ + ILL++F+
Sbjct: 690 DNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFL 749
Query: 596 AVILDNLELDEDLKKLKQLKQSE---------ANADTKEKLPLRLRIFEKFPNRPQMVKI 646
A+ +DNL E L ++ ++ E A+ + K++L + + E ++ + +++
Sbjct: 750 AIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE---SKEEKIEL 806
Query: 647 SKLPSDFTVPKIRESFMKQFIDRQQQD 673
+ +D P + M + +D
Sbjct: 807 KSITADGESPPATKINMDDLQPNENED 833
Score = 104 bits (260), Expect = 7e-22
Identities = 94/357 (26%), Positives = 164/357 (45%), Gaps = 62/357 (17%)
Query: 885 VTYLDW----VMIIVTI-CSCISMMFESPFRRVMHAPT---LQIAEYVFVIFMSIELNLK 936
++ ++W ++I++TI +C+++ PF T L+ EY+F+I ++E LK
Sbjct: 118 ISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLK 177
Query: 937 IMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQL-----------L 985
++A GL F P A +R+ ++D I +V L F + Q A+ L L
Sbjct: 178 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGL-FSAILEQATKADGANALGGKGAGFDVKAL 236
Query: 986 MVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAK 1045
R LRPLR+ VP ++ V+ + + +++L+L +++++A G++LF GK+ K
Sbjct: 237 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
Query: 1046 C-------------NDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWAN 1092
+DP+ E +G N +V K PG W
Sbjct: 297 TCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCK-------PG-----------WDG 338
Query: 1093 PRN--FNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVG-PIHGIYIHVFVFLGCMIGLT 1149
P++ NFDN AML +F+ ++++GW +V + VG IY + +G L
Sbjct: 339 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLN 398
Query: 1150 LFVGVVIANFNENKGTALLTVD-------QRRWEDLKSRLK-IAQPLHLPPRPDNDG 1198
L +GV+ F++ + A D Q+ EDLK L I Q + P +++G
Sbjct: 399 LVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEG 455
Score = 95.1 bits (235), Expect = 5e-19
Identities = 133/654 (20%), Positives = 262/654 (40%), Gaps = 125/654 (19%)
Query: 33 INKPWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHI 92
+N +L+ ++S IS+ P+ +H ++ F D + ++T E+ KM
Sbjct: 897 VNDTIFTNLILFFILLSSISLAAEDPV--QHTSFRNHILFYFDIVFTTIFTIEIALKMTA 954
Query: 93 RGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIR 152
G S+ ++ + + D L VS+ L F I Q S +++I R L ++R
Sbjct: 955 YGAFLHKGSFCRNYFNILD-----LLVVSVSLISFGI-----QSSAINVVKILRVLRVLR 1004
Query: 153 AFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDT 212
R R + + + + + I ++ I ++ +GVQ+F Y C + +
Sbjct: 1005 PLRAINRAKGLK-HVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS-DSS 1062
Query: 213 KPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFT 272
K I T+ E++ P ++ + F+ + ++
Sbjct: 1063 KQTEAECKGNYI--TYKDGEVDHPIIQPRSWENSKFD-------------FDNVLAAMMA 1107
Query: 273 VYEAASQEGWVFLMYRAIDSFPRWRSYFY---------FITLIFFLAWLVKNVFIAVIIE 323
++ ++ EGW L+YR+IDS + Y FI I +A+ + N+F+ +I
Sbjct: 1108 LFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1167
Query: 324 TFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPACLQKMMRS 383
TF E Q +Q + + + + A + + P+ + + ++ S
Sbjct: 1168 TFQE---QGEQEYKNCELDKNQRQCVEYALKARPLRRYI------PKNQHQYKVWYVVNS 1218
Query: 384 SVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFT 443
+ F + ++ ++ I A +Y G++ + + + FT LF +E +LK+
Sbjct: 1219 TYFEYLMFVLILLNTICLAMQHY-GQSCLFKI-AMNILNMLFTGLFTVEMILKLIAFKPK 1276
Query: 444 GYISSSLHKFELLLVIGT--------TLHVYPDLY------------------------H 471
GY S + F+ L+VIG+ T H + D + H
Sbjct: 1277 GYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEH 1336
Query: 472 SQ--------------FTYFQVLRVVRLIKI---SPALEDFVYKIFGPGKKLGSLVVFTA 514
+Q T+F++ RV+RL+K+ + ++ + L + +
Sbjct: 1337 TQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIV 1396
Query: 515 SLLIVMSAISLQMFCFVE-----ELDR---FTTFPRAFMSMFQILTQEGWVDVMDQTLNA 566
L + + I +Q+F + E++R F TFP+A + +F+ T E W D+M +
Sbjct: 1397 MLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMP- 1455
Query: 567 VGHMWAP-----------------VVAIYFILYHLFATLILLSLFVAVILDNLE 603
G AP YFI +++ ++++LFVAVI+DN +
Sbjct: 1456 -GKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFD 1508
Score = 78.2 bits (191), Expect = 7e-14
Identities = 57/250 (22%), Positives = 122/250 (48%), Gaps = 17/250 (6%)
Query: 1206 ITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSP 1265
+ + F+ I L+ L + S ++ + +T T + +F E+ +K+ ++
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1266 AGFWQSRRNRYDLLVTSLGVVWVVL-HFALLNAYTYMMGACVIVFRFFSICGKHVTLKML 1324
++ S NR+D V G++ +L +++ + CV + R F I +L L
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1325 LLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFG-TVKYGENINRHANFSSAGKAITVLF 1383
+ +++ S+ +++ +FL ++ ++ G+ LFG + E R + F + +++ +F
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVF 700
Query: 1384 RIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGAL--MYFCSFYVIIAYIMLNL 1441
+I+TGEDWN +M+D ++ A ++ G L +YF ++ YI+LN+
Sbjct: 701 QILTGEDWNSVMYDGIM-------------AYGGPSFPGMLVCIYFIILFICGNYILLNV 747
Query: 1442 LVAIIVENFS 1451
+AI V+N +
Sbjct: 748 FLAIAVDNLA 757
Score = 58.9 bits (141), Expect = 4e-08
Identities = 68/287 (23%), Positives = 120/287 (41%), Gaps = 68/287 (23%)
Query: 50 VISVCMNT-PMTFEHYPPLQYVTFTLDTL---LMFLYTAEMIAKMHIRGIVKGDSSYVKD 105
+ V +NT + EHY ++T DT L+ L+TAEM+ KM+ G+ +Y
Sbjct: 531 IFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL----QAYFVS 586
Query: 106 RWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRT 165
+ FD F+V + +L +I MSP G + + R + ++R F+I R+ +
Sbjct: 587 LFNRFDCFVVCGGILETILVETKI------MSPLG-ISVLRCVRLLRIFKIT-RYWNSLS 638
Query: 166 RITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIP 225
+ L S I S+ + L F++++ +LG+Q+FG G ++ +
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFG-------------GKFNFDEM--- 682
Query: 226 DTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFL 285
+ S F+ S+ TV++ + E W +
Sbjct: 683 -------------------------------QTRRSTFDNFPQSLLTVFQILTGEDWNSV 711
Query: 286 MYRAI-----DSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAE 327
MY I SFP YFI L +++ NVF+A+ ++ A+
Sbjct: 712 MYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLAD 758
Score = 51.2 bits (121), Expect = 9e-06
Identities = 64/306 (20%), Positives = 120/306 (39%), Gaps = 62/306 (20%)
Query: 890 WVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAV 949
W++I + + +++ E + A + + E+ LK+ + GL ++
Sbjct: 528 WLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSL 587
Query: 950 IRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVP---QMRKV 1006
F D F+ ++ + + + G + VLRC+R LRIFK+ + +
Sbjct: 588 FNRF----DCFVVCGGILETILVETKIMSPLG---ISVLRCVRLLRIFKITRYWNSLSNL 640
Query: 1007 VRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVS 1066
V L + + I + +LL +++F+ G+QLF GK F +
Sbjct: 641 VASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGK------------------FNFDE- 681
Query: 1067 VSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVR-DVII 1125
R FDN ++L +F++L+ + W V D I+
Sbjct: 682 ------------------------MQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIM 717
Query: 1126 HRVGP-----IHGIYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKS 1180
GP + IY + G I L +F+ + + N + + LT Q+ E+ K
Sbjct: 718 AYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAES---LTSAQKEEEEEKE 774
Query: 1181 RLKIAQ 1186
R K+A+
Sbjct: 775 RKKLAR 780
Score = 41.6 bits (96), Expect = 0.007
Identities = 57/300 (19%), Positives = 110/300 (36%), Gaps = 76/300 (25%)
Query: 1212 FKRTIALLVLAQSVLLSV----KWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMS--- 1264
F+ I L + A V L++ D + L + +F IF +E +K+IA
Sbjct: 126 FEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLF 185
Query: 1265 -PAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGA-----------CVIVFRFF 1312
P + ++ N D ++ +G+ +L A +G V R
Sbjct: 186 HPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPL 245
Query: 1313 SICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLF--------------- 1357
+ +L+++L +++ +M I + + +++ YA G+ LF
Sbjct: 246 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIA 305
Query: 1358 -----------------------GTV-KYGENINRHA--NFSSAGKAITVLFRIVTGEDW 1391
GTV K G + +H NF + A+ +F+ +T E W
Sbjct: 306 DVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGW 365
Query: 1392 NKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFS 1451
++ YW D +YF + +I ++ +LNL++ ++ FS
Sbjct: 366 TDVL----------------YWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFS 409
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.327 0.139 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,348,963
Number of Sequences: 37866
Number of extensions: 2649714
Number of successful extensions: 14448
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 85
Number of HSP's successfully gapped in prelim test: 115
Number of HSP's that attempted gapping in prelim test: 10891
Number of HSP's gapped (non-prelim): 1871
length of query: 1738
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1622
effective length of database: 13,855,062
effective search space: 22472910564
effective search space used: 22472910564
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.