Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 239787092

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239787092 A20-binding inhibitor of NF-kappaB activation 2
isoform 1 [Homo sapiens]
         (429 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239787092 A20-binding inhibitor of NF-kappaB activation 2 iso...   853   0.0  
gi|239787094 A20-binding inhibitor of NF-kappaB activation 2 iso...   650   0.0  
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]           68   2e-11
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]           68   2e-11
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]           68   2e-11
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi...    64   3e-10
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     62   8e-10
gi|223671870 inhibitor of kappa light polypeptide gene enhancer ...    62   8e-10
gi|4504631 inhibitor of kappa light polypeptide gene enhancer in...    62   8e-10
gi|153792133 inhibitor of kappa light polypeptide gene enhancer ...    62   8e-10
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         62   1e-09
gi|126723390 ankyrin repeat domain 24 [Homo sapiens]                   62   1e-09
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    61   2e-09
gi|87298937 centrosomal protein 110kDa [Homo sapiens]                  61   2e-09
gi|121582655 ankyrin repeat domain 35 [Homo sapiens]                   61   2e-09
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        60   3e-09
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        60   3e-09
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         60   3e-09
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         60   3e-09
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         60   3e-09
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         60   3e-09
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         60   3e-09
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         60   3e-09
gi|148746195 trichohyalin [Homo sapiens]                               60   4e-09
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap...    60   5e-09
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    60   5e-09
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    60   5e-09
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    60   5e-09
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    60   5e-09
gi|31982906 cingulin-like 1 [Homo sapiens]                             60   5e-09

>gi|239787092 A20-binding inhibitor of NF-kappaB activation 2
           isoform 1 [Homo sapiens]
          Length = 429

 Score =  853 bits (2203), Expect = 0.0
 Identities = 429/429 (100%), Positives = 429/429 (100%)

Query: 1   MSRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAA 60
           MSRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAA
Sbjct: 1   MSRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAA 60

Query: 61  PSLVDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHERE 120
           PSLVDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHERE
Sbjct: 61  PSLVDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHERE 120

Query: 121 KEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQR 180
           KEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQR
Sbjct: 121 KEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQR 180

Query: 181 NVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRG 240
           NVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRG
Sbjct: 181 NVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRG 240

Query: 241 LHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLE 300
           LHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLE
Sbjct: 241 LHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLE 300

Query: 301 QQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360
           QQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK
Sbjct: 301 QQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360

Query: 361 YLAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPHCLQCFSDEQGEEL 420
           YLAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPHCLQCFSDEQGEEL
Sbjct: 361 YLAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPHCLQCFSDEQGEEL 420

Query: 421 LRHVAECCQ 429
           LRHVAECCQ
Sbjct: 421 LRHVAECCQ 429


>gi|239787094 A20-binding inhibitor of NF-kappaB activation 2
           isoform 2 [Homo sapiens]
          Length = 322

 Score =  650 bits (1676), Expect = 0.0
 Identities = 322/322 (100%), Positives = 322/322 (100%)

Query: 108 MQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQH 167
           MQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQH
Sbjct: 1   MQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQH 60

Query: 168 LAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW 227
           LAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW
Sbjct: 61  LAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW 120

Query: 228 QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287
           QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT
Sbjct: 121 QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 180

Query: 288 ARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREP 347
           ARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREP
Sbjct: 181 ARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREP 240

Query: 348 DAGRIHAGSKTAKYLAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPH 407
           DAGRIHAGSKTAKYLAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPH
Sbjct: 241 DAGRIHAGSKTAKYLAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPH 300

Query: 408 CLQCFSDEQGEELLRHVAECCQ 429
           CLQCFSDEQGEELLRHVAECCQ
Sbjct: 301 CLQCFSDEQGEELLRHVAECCQ 322


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 84/358 (23%), Positives = 148/358 (41%), Gaps = 29/358 (8%)

Query: 15   RAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARF 74
            RA   L T   +  +  RR +++  A +A       R AA E +A    +    E V R 
Sbjct: 1386 RAGRELQTAQAQLSEWRRRQEEEAGALEA--GEEARRRAAREAEALTQRLAEKTETVDRL 1443

Query: 75   REQLRRQEGGAAEAQMRQEIER-LTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG 133
                RR +    +A M  E +R L   LE+K+R+  QLL++ +    + V    R+ AEG
Sbjct: 1444 ERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEG 1503

Query: 134  ERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHT 193
                A +  L R+L  E             +   L   L  +    ++V E         
Sbjct: 1504 REREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHE--------- 1554

Query: 194  DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
                 ++      ++    L+ +VT +ED         A+ D  +R L   ++ L+  HE
Sbjct: 1555 -----LERACRVAEQAANDLRAQVTELED------ELTAAEDAKLR-LEVTVQALKTQHE 1602

Query: 254  PELMRKEIS--RLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFM 311
             +L  ++ +     RQL +++ D AEV+++    R  R  A+   + LE ++   K    
Sbjct: 1603 RDLQGRDEAGEERRRQLAKQLRD-AEVERD--EERKQRTLAVAARKKLEGELEELKAQMA 1659

Query: 312  SERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALEL 369
            S    +E A  ++++++ ++  L  +V   + SRE    +     K  K L A+ L L
Sbjct: 1660 SAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRL 1717



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 79/361 (21%), Positives = 154/361 (42%), Gaps = 54/361 (14%)

Query: 34   LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEAQMRQE 93
            LQ+Q+  +      LRA+L   E +   +L  A  E  AR +     +E  AA A+ +++
Sbjct: 1092 LQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQED 1151

Query: 94   IER--------------LTERLEEKEREMQQLL------SQPQHEREKEVVLLRRSMAEG 133
            +E               L E LE    E++  L       + + +RE+EV  L++++ E 
Sbjct: 1152 LESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEE 1211

Query: 134  ERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG-------ERS 186
             R   A+            +LR+         Q L +  ++ + A+R  G          
Sbjct: 1212 TRIHEAA----------VQELRQ------RHGQALGELAEQLEQARRGKGAWEKTRLALE 1255

Query: 187  PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246
             + SE     +S+Q+  ++ ++  R L+ ++  V+      +R  A   E ++   A+L 
Sbjct: 1256 AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE 1315

Query: 247  GLQ-IPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILA 305
             +    +E E     +S+     E +++D  E+ QE   ++ A  +   RV+ +E +   
Sbjct: 1316 NVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS---RVRAMEAEAAG 1372

Query: 306  YKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAAD 365
             ++    E A RERA   +Q  + +++       WR+  +E +AG + AG +  +  A +
Sbjct: 1373 LREQLEEEAAARERAGRELQTAQAQLS------EWRR-RQEEEAGALEAGEEARRRAARE 1425

Query: 366  A 366
            A
Sbjct: 1426 A 1426



 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 71/308 (23%), Positives = 134/308 (43%), Gaps = 27/308 (8%)

Query: 71   VARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSM 130
            +A   ++LR++E G      RQE+E+L  RL+ +  E+Q+ + + Q   E+    L R  
Sbjct: 1061 IADMEDRLRKEEKG------RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKE 1114

Query: 131  AEGERARAASDVLCRSLANETHQLRRTLTATAHM-----CQHLAKCLDERQHAQRNVGER 185
             E + A A ++    + A     LR    A A        + +A+   E+Q  +R++GE 
Sbjct: 1115 EELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQ--RRDLGEE 1172

Query: 186  SP---DQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLH 242
                  + E T   T+ Q  +   +E      Q+VT ++    +  R + +  + +R  H
Sbjct: 1173 LEALRGELEDTLDSTNAQQELRSKRE------QEVTELKKTLEEETRIHEAAVQELRQRH 1226

Query: 243  AQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQ 302
             Q  G ++  + E  R+      +       + +E++ EL++ +TAR    +R + LE Q
Sbjct: 1227 GQALG-ELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQ 1285

Query: 303  ILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYL 362
            +     +      D ERA++   E  ++  + L  VS   +  E    R+     + +  
Sbjct: 1286 L----QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ 1341

Query: 363  AADALELM 370
              DA EL+
Sbjct: 1342 LHDAQELL 1349



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 75/331 (22%), Positives = 139/331 (41%), Gaps = 46/331 (13%)

Query: 29   QRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEA 88
            Q+++ LQ Q A     +  L+ R+A LE            E+ AR  EQLR +    AEA
Sbjct: 887  QKVQELQQQSARE---VGELQGRVAQLE------------EERARLAEQLRAEAELCAEA 931

Query: 89   Q--------MRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAAS 140
            +         +QE+E +   LE +  E ++   Q Q E+++    ++   A  E    A 
Sbjct: 932  EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGAR 991

Query: 141  DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQ 200
              L         ++++       +    +K   ER+  +  + E S   +E         
Sbjct: 992  QKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEE------- 1044

Query: 201  SVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKE 260
               EK++  N+L  +    + D+  + ++    R E +  L  +L G     E   ++++
Sbjct: 1045 ---EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE-LEKLKRRLDG-----ESSELQEQ 1095

Query: 261  ISRLNRQLEEKINDCAEVKQEL-AASRTARDAALERVQMLE-----QQILA-YKDDFMSE 313
            +    ++ EE        ++EL AA   A D    R Q+L+     Q  LA  ++D  SE
Sbjct: 1096 MVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESE 1155

Query: 314  RADRERAQSRIQELEEKVASLLHQVSWRQDS 344
            R  R +A+ + ++L E++ +L  ++    DS
Sbjct: 1156 RVARTKAEKQRRDLGEELEALRGELEDTLDS 1186



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 79/369 (21%), Positives = 145/369 (39%), Gaps = 59/369 (15%)

Query: 11   EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEG------DAAPSLV 64
            EE  RA A        A    R L+++  AR+ L  + RA  A LE       D   S+ 
Sbjct: 1494 EERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVH 1553

Query: 65   DALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKER-EMQQLLSQPQHEREKEV 123
            +  LE+  R  EQ          AQ+ +  + LT   + K R E+     + QHER+ + 
Sbjct: 1554 E--LERACRVAEQAAND----LRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQG 1607

Query: 124  VLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG 183
               R    E  R + A  +    +  +  + +RTL   A            R+  +  + 
Sbjct: 1608 ---RDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAA------------RKKLEGELE 1652

Query: 184  ERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHA 243
            E     +    G       + K+Q + + L ++V        +    N   ++ ++GL A
Sbjct: 1653 ELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEA 1712

Query: 244  QLRGLQ------------IPHEPELMRKEISRLN----------RQLEEKINDCAEVKQE 281
            ++  LQ               + + M  E++  N          RQLE ++    ++++E
Sbjct: 1713 EVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLG---QLEEE 1769

Query: 282  LAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWR 341
            L   ++  +   +R + L  Q+ +   +  +ER+   +A+S  Q+LE ++  L  ++   
Sbjct: 1770 LEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLG-- 1827

Query: 342  QDSREPDAG 350
                E DAG
Sbjct: 1828 ----EEDAG 1832


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 84/358 (23%), Positives = 148/358 (41%), Gaps = 29/358 (8%)

Query: 15   RAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARF 74
            RA   L T   +  +  RR +++  A +A       R AA E +A    +    E V R 
Sbjct: 1378 RAGRELQTAQAQLSEWRRRQEEEAGALEA--GEEARRRAAREAEALTQRLAEKTETVDRL 1435

Query: 75   REQLRRQEGGAAEAQMRQEIER-LTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG 133
                RR +    +A M  E +R L   LE+K+R+  QLL++ +    + V    R+ AEG
Sbjct: 1436 ERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEG 1495

Query: 134  ERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHT 193
                A +  L R+L  E             +   L   L  +    ++V E         
Sbjct: 1496 REREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHE--------- 1546

Query: 194  DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
                 ++      ++    L+ +VT +ED         A+ D  +R L   ++ L+  HE
Sbjct: 1547 -----LERACRVAEQAANDLRAQVTELED------ELTAAEDAKLR-LEVTVQALKTQHE 1594

Query: 254  PELMRKEIS--RLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFM 311
             +L  ++ +     RQL +++ D AEV+++    R  R  A+   + LE ++   K    
Sbjct: 1595 RDLQGRDEAGEERRRQLAKQLRD-AEVERD--EERKQRTLAVAARKKLEGELEELKAQMA 1651

Query: 312  SERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALEL 369
            S    +E A  ++++++ ++  L  +V   + SRE    +     K  K L A+ L L
Sbjct: 1652 SAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRL 1709



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 79/361 (21%), Positives = 154/361 (42%), Gaps = 54/361 (14%)

Query: 34   LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEAQMRQE 93
            LQ+Q+  +      LRA+L   E +   +L  A  E  AR +     +E  AA A+ +++
Sbjct: 1084 LQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQED 1143

Query: 94   IER--------------LTERLEEKEREMQQLL------SQPQHEREKEVVLLRRSMAEG 133
            +E               L E LE    E++  L       + + +RE+EV  L++++ E 
Sbjct: 1144 LESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEE 1203

Query: 134  ERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG-------ERS 186
             R   A+            +LR+         Q L +  ++ + A+R  G          
Sbjct: 1204 TRIHEAA----------VQELRQ------RHGQALGELAEQLEQARRGKGAWEKTRLALE 1247

Query: 187  PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246
             + SE     +S+Q+  ++ ++  R L+ ++  V+      +R  A   E ++   A+L 
Sbjct: 1248 AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE 1307

Query: 247  GLQ-IPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILA 305
             +    +E E     +S+     E +++D  E+ QE   ++ A  +   RV+ +E +   
Sbjct: 1308 NVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS---RVRAMEAEAAG 1364

Query: 306  YKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAAD 365
             ++    E A RERA   +Q  + +++       WR+  +E +AG + AG +  +  A +
Sbjct: 1365 LREQLEEEAAARERAGRELQTAQAQLS------EWRR-RQEEEAGALEAGEEARRRAARE 1417

Query: 366  A 366
            A
Sbjct: 1418 A 1418



 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 71/308 (23%), Positives = 134/308 (43%), Gaps = 27/308 (8%)

Query: 71   VARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSM 130
            +A   ++LR++E G      RQE+E+L  RL+ +  E+Q+ + + Q   E+    L R  
Sbjct: 1053 IADMEDRLRKEEKG------RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKE 1106

Query: 131  AEGERARAASDVLCRSLANETHQLRRTLTATAHM-----CQHLAKCLDERQHAQRNVGER 185
             E + A A ++    + A     LR    A A        + +A+   E+Q  +R++GE 
Sbjct: 1107 EELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQ--RRDLGEE 1164

Query: 186  SP---DQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLH 242
                  + E T   T+ Q  +   +E      Q+VT ++    +  R + +  + +R  H
Sbjct: 1165 LEALRGELEDTLDSTNAQQELRSKRE------QEVTELKKTLEEETRIHEAAVQELRQRH 1218

Query: 243  AQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQ 302
             Q  G ++  + E  R+      +       + +E++ EL++ +TAR    +R + LE Q
Sbjct: 1219 GQALG-ELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQ 1277

Query: 303  ILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYL 362
            +     +      D ERA++   E  ++  + L  VS   +  E    R+     + +  
Sbjct: 1278 L----QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ 1333

Query: 363  AADALELM 370
              DA EL+
Sbjct: 1334 LHDAQELL 1341



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 75/331 (22%), Positives = 139/331 (41%), Gaps = 46/331 (13%)

Query: 29   QRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEA 88
            Q+++ LQ Q A     +  L+ R+A LE            E+ AR  EQLR +    AEA
Sbjct: 879  QKVQELQQQSARE---VGELQGRVAQLE------------EERARLAEQLRAEAELCAEA 923

Query: 89   Q--------MRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAAS 140
            +         +QE+E +   LE +  E ++   Q Q E+++    ++   A  E    A 
Sbjct: 924  EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGAR 983

Query: 141  DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQ 200
              L         ++++       +    +K   ER+  +  + E S   +E         
Sbjct: 984  QKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEE------- 1036

Query: 201  SVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKE 260
               EK++  N+L  +    + D+  + ++    R E +  L  +L G     E   ++++
Sbjct: 1037 ---EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE-LEKLKRRLDG-----ESSELQEQ 1087

Query: 261  ISRLNRQLEEKINDCAEVKQEL-AASRTARDAALERVQMLE-----QQILA-YKDDFMSE 313
            +    ++ EE        ++EL AA   A D    R Q+L+     Q  LA  ++D  SE
Sbjct: 1088 MVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESE 1147

Query: 314  RADRERAQSRIQELEEKVASLLHQVSWRQDS 344
            R  R +A+ + ++L E++ +L  ++    DS
Sbjct: 1148 RVARTKAEKQRRDLGEELEALRGELEDTLDS 1178



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 79/369 (21%), Positives = 145/369 (39%), Gaps = 59/369 (15%)

Query: 11   EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEG------DAAPSLV 64
            EE  RA A        A    R L+++  AR+ L  + RA  A LE       D   S+ 
Sbjct: 1486 EERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVH 1545

Query: 65   DALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKER-EMQQLLSQPQHEREKEV 123
            +  LE+  R  EQ          AQ+ +  + LT   + K R E+     + QHER+ + 
Sbjct: 1546 E--LERACRVAEQAAND----LRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQG 1599

Query: 124  VLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG 183
               R    E  R + A  +    +  +  + +RTL   A            R+  +  + 
Sbjct: 1600 ---RDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAA------------RKKLEGELE 1644

Query: 184  ERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHA 243
            E     +    G       + K+Q + + L ++V        +    N   ++ ++GL A
Sbjct: 1645 ELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEA 1704

Query: 244  QLRGLQ------------IPHEPELMRKEISRLN----------RQLEEKINDCAEVKQE 281
            ++  LQ               + + M  E++  N          RQLE ++    ++++E
Sbjct: 1705 EVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLG---QLEEE 1761

Query: 282  LAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWR 341
            L   ++  +   +R + L  Q+ +   +  +ER+   +A+S  Q+LE ++  L  ++   
Sbjct: 1762 LEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLG-- 1819

Query: 342  QDSREPDAG 350
                E DAG
Sbjct: 1820 ----EEDAG 1824


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 84/358 (23%), Positives = 148/358 (41%), Gaps = 29/358 (8%)

Query: 15   RAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARF 74
            RA   L T   +  +  RR +++  A +A       R AA E +A    +    E V R 
Sbjct: 1419 RAGRELQTAQAQLSEWRRRQEEEAGALEA--GEEARRRAAREAEALTQRLAEKTETVDRL 1476

Query: 75   REQLRRQEGGAAEAQMRQEIER-LTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG 133
                RR +    +A M  E +R L   LE+K+R+  QLL++ +    + V    R+ AEG
Sbjct: 1477 ERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEG 1536

Query: 134  ERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHT 193
                A +  L R+L  E             +   L   L  +    ++V E         
Sbjct: 1537 REREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHE--------- 1587

Query: 194  DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
                 ++      ++    L+ +VT +ED         A+ D  +R L   ++ L+  HE
Sbjct: 1588 -----LERACRVAEQAANDLRAQVTELED------ELTAAEDAKLR-LEVTVQALKTQHE 1635

Query: 254  PELMRKEIS--RLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFM 311
             +L  ++ +     RQL +++ D AEV+++    R  R  A+   + LE ++   K    
Sbjct: 1636 RDLQGRDEAGEERRRQLAKQLRD-AEVERD--EERKQRTLAVAARKKLEGELEELKAQMA 1692

Query: 312  SERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALEL 369
            S    +E A  ++++++ ++  L  +V   + SRE    +     K  K L A+ L L
Sbjct: 1693 SAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRL 1750



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 79/361 (21%), Positives = 154/361 (42%), Gaps = 54/361 (14%)

Query: 34   LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEAQMRQE 93
            LQ+Q+  +      LRA+L   E +   +L  A  E  AR +     +E  AA A+ +++
Sbjct: 1125 LQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQED 1184

Query: 94   IER--------------LTERLEEKEREMQQLL------SQPQHEREKEVVLLRRSMAEG 133
            +E               L E LE    E++  L       + + +RE+EV  L++++ E 
Sbjct: 1185 LESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEE 1244

Query: 134  ERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG-------ERS 186
             R   A+            +LR+         Q L +  ++ + A+R  G          
Sbjct: 1245 TRIHEAA----------VQELRQ------RHGQALGELAEQLEQARRGKGAWEKTRLALE 1288

Query: 187  PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246
             + SE     +S+Q+  ++ ++  R L+ ++  V+      +R  A   E ++   A+L 
Sbjct: 1289 AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE 1348

Query: 247  GLQ-IPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILA 305
             +    +E E     +S+     E +++D  E+ QE   ++ A  +   RV+ +E +   
Sbjct: 1349 NVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS---RVRAMEAEAAG 1405

Query: 306  YKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAAD 365
             ++    E A RERA   +Q  + +++       WR+  +E +AG + AG +  +  A +
Sbjct: 1406 LREQLEEEAAARERAGRELQTAQAQLS------EWRR-RQEEEAGALEAGEEARRRAARE 1458

Query: 366  A 366
            A
Sbjct: 1459 A 1459



 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 71/308 (23%), Positives = 134/308 (43%), Gaps = 27/308 (8%)

Query: 71   VARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSM 130
            +A   ++LR++E G      RQE+E+L  RL+ +  E+Q+ + + Q   E+    L R  
Sbjct: 1094 IADMEDRLRKEEKG------RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKE 1147

Query: 131  AEGERARAASDVLCRSLANETHQLRRTLTATAHM-----CQHLAKCLDERQHAQRNVGER 185
             E + A A ++    + A     LR    A A        + +A+   E+Q  +R++GE 
Sbjct: 1148 EELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQ--RRDLGEE 1205

Query: 186  SP---DQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLH 242
                  + E T   T+ Q  +   +E      Q+VT ++    +  R + +  + +R  H
Sbjct: 1206 LEALRGELEDTLDSTNAQQELRSKRE------QEVTELKKTLEEETRIHEAAVQELRQRH 1259

Query: 243  AQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQ 302
             Q  G ++  + E  R+      +       + +E++ EL++ +TAR    +R + LE Q
Sbjct: 1260 GQALG-ELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQ 1318

Query: 303  ILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYL 362
            +     +      D ERA++   E  ++  + L  VS   +  E    R+     + +  
Sbjct: 1319 L----QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ 1374

Query: 363  AADALELM 370
              DA EL+
Sbjct: 1375 LHDAQELL 1382



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 75/331 (22%), Positives = 139/331 (41%), Gaps = 46/331 (13%)

Query: 29   QRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEA 88
            Q+++ LQ Q A     +  L+ R+A LE            E+ AR  EQLR +    AEA
Sbjct: 920  QKVQELQQQSARE---VGELQGRVAQLE------------EERARLAEQLRAEAELCAEA 964

Query: 89   Q--------MRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAAS 140
            +         +QE+E +   LE +  E ++   Q Q E+++    ++   A  E    A 
Sbjct: 965  EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGAR 1024

Query: 141  DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQ 200
              L         ++++       +    +K   ER+  +  + E S   +E         
Sbjct: 1025 QKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEE------- 1077

Query: 201  SVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKE 260
               EK++  N+L  +    + D+  + ++    R E +  L  +L G     E   ++++
Sbjct: 1078 ---EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE-LEKLKRRLDG-----ESSELQEQ 1128

Query: 261  ISRLNRQLEEKINDCAEVKQEL-AASRTARDAALERVQMLE-----QQILA-YKDDFMSE 313
            +    ++ EE        ++EL AA   A D    R Q+L+     Q  LA  ++D  SE
Sbjct: 1129 MVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESE 1188

Query: 314  RADRERAQSRIQELEEKVASLLHQVSWRQDS 344
            R  R +A+ + ++L E++ +L  ++    DS
Sbjct: 1189 RVARTKAEKQRRDLGEELEALRGELEDTLDS 1219



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 79/369 (21%), Positives = 145/369 (39%), Gaps = 59/369 (15%)

Query: 11   EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEG------DAAPSLV 64
            EE  RA A        A    R L+++  AR+ L  + RA  A LE       D   S+ 
Sbjct: 1527 EERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVH 1586

Query: 65   DALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKER-EMQQLLSQPQHEREKEV 123
            +  LE+  R  EQ          AQ+ +  + LT   + K R E+     + QHER+ + 
Sbjct: 1587 E--LERACRVAEQAAND----LRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQG 1640

Query: 124  VLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG 183
               R    E  R + A  +    +  +  + +RTL   A            R+  +  + 
Sbjct: 1641 ---RDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAA------------RKKLEGELE 1685

Query: 184  ERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHA 243
            E     +    G       + K+Q + + L ++V        +    N   ++ ++GL A
Sbjct: 1686 ELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEA 1745

Query: 244  QLRGLQ------------IPHEPELMRKEISRLN----------RQLEEKINDCAEVKQE 281
            ++  LQ               + + M  E++  N          RQLE ++    ++++E
Sbjct: 1746 EVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLG---QLEEE 1802

Query: 282  LAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWR 341
            L   ++  +   +R + L  Q+ +   +  +ER+   +A+S  Q+LE ++  L  ++   
Sbjct: 1803 LEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLG-- 1860

Query: 342  QDSREPDAG 350
                E DAG
Sbjct: 1861 ----EEDAG 1865


>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo
           sapiens]
          Length = 1478

 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 81/338 (23%), Positives = 141/338 (41%), Gaps = 34/338 (10%)

Query: 19  ALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGD--AAPSLVDALLEQVARFRE 76
           AL   Y    QR   +Q  LA+ +A  A +R     +E    A     +A+  Q+A    
Sbjct: 641 ALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEA 700

Query: 77  QLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG--- 133
            L+ +EG     Q+R+E+E+  +  E + RE++ L SQ Q + +   VL      +G   
Sbjct: 701 ILQSKEGECQ--QLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGP 758

Query: 134 ---ERARAASDVLCRSLAN-ETHQ--LRRTLTATAHMCQHLAKCLDERQHAQRNVGERSP 187
                AR  +  L  S A  E HQ  ++R       +   +   LD++   Q  +     
Sbjct: 759 PTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEA 818

Query: 188 DQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNA----------SRDEY 237
              EH       ++++++L+E+N  L +   HV++L    +R  A           R+E 
Sbjct: 819 VLREH-------KTLVQQLKEQNEALNR--AHVQELLQCSEREGALQEERADEAQQREEE 869

Query: 238 VRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQ 297
           +R L  +L   Q     E  + E + L  QL     D AE+  ++ A    ++   E + 
Sbjct: 870 LRALQEELS--QAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALA 927

Query: 298 MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLL 335
              Q++   K+    ER   ER  + +Q+ +E +   L
Sbjct: 928 CAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKL 965



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 97/432 (22%), Positives = 169/432 (39%), Gaps = 61/432 (14%)

Query: 26   EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVD--------ALLEQVARFREQ 77
            E   +L   Q QL      + RL+A++  L+     +L D        ++ E V R  + 
Sbjct: 766  ELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKT 825

Query: 78   LRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERAR 137
            L +Q     EA  R  ++ L +   E+E  +Q+  +    +RE+E+  L+  +++   A+
Sbjct: 826  LVQQLKEQNEALNRAHVQELLQ-CSEREGALQEERADEAQQREEELRALQEELSQ---AK 881

Query: 138  AASDVLCRSLANETHQLRRTLTATAHM----C----------QHLAKCLDERQHAQRNVG 183
             +S+      A    QL R  T TA +    C          + LA  + E Q A+    
Sbjct: 882  CSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAAS 941

Query: 184  ERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHA 243
                       G   +Q   E LQE+ +  K     +  L A+  +            H 
Sbjct: 942  REREGLERQVAG---LQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQ 998

Query: 244  QLRGLQIPHEPELMR---------KEISRLNRQLEEK---INDCAEVKQELAASR----- 286
            +L  L+     E+M          +E   L  QLEE+   +    E  ++L A++     
Sbjct: 999  ELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGE 1058

Query: 287  ----TARDAALERVQML--EQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSW 340
                T+   A  +  ML  +++  A ++D    + + E+A ++IQE   K   L  +V+ 
Sbjct: 1059 KLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNK---LCQEVTN 1115

Query: 341  RQDSREPDAGRIHAGSKTAKYLAADALELMVPGGWRPGTGSQQPEPPAEGGHP-GAAQRG 399
            R+ + +     +   ++T KYL    +EL+     R      Q     E      A +R 
Sbjct: 1116 RERNDQKMLADLDDLNRTKKYLEERLIELL-----RDKDALWQKSDALEFQQKLSAEERW 1170

Query: 400  QGDLQCPHCLQC 411
             GD +  HCL C
Sbjct: 1171 LGDTEANHCLDC 1182



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 82/371 (22%), Positives = 149/371 (40%), Gaps = 38/371 (10%)

Query: 26  EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ-EGG 84
           E    +R   DQL  R+    +LR R+  L+ +        L   V++  EQL+ + E G
Sbjct: 230 EGFDEMRLELDQLEVREK---QLRERMQQLDREN-----QELRAAVSQQGEQLQTERERG 281

Query: 85  AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGER----ARAAS 140
              A+    +  L   L+ K+ E+ Q       E +  +  L    AE E     A    
Sbjct: 282 RTAAEDNVRLTCLVAELQ-KQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRL 340

Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQ 200
           + + + LA E    R +L       QHLA        AQ+     S  +       +   
Sbjct: 341 ESMLQPLAQELEATRDSLDKKN---QHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAA 397

Query: 201 SVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKE 260
             +++L E+ + L+++ T VE++N   ++ +A  ++ V+               EL  KE
Sbjct: 398 QEMQELGEKLQALERERTKVEEVN---RQQSAQLEQLVK---------------ELQLKE 439

Query: 261 ISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERA 320
            +R +  LE  + + A +++EL+      D    R+Q L     +++++    R ++++ 
Sbjct: 440 DARAS--LERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQ 497

Query: 321 QSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALELMVPGGWRPG-T 379
           Q   + LE++V SL  Q+ + +      +  +    +  K L  D   L    G      
Sbjct: 498 QEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLA 557

Query: 380 GSQQPEPPAEG 390
           G   PE P  G
Sbjct: 558 GPPGPELPVAG 568


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 62.4 bits (150), Expect = 8e-10
 Identities = 78/317 (24%), Positives = 144/317 (45%), Gaps = 51/317 (16%)

Query: 33   RLQDQLAARDALIAR---LRARLAALEGDAAPSLVDALLEQVARFREQLRR-QEGGAAEA 88
            +LQ+QL A   L A    LRARL A + +    L +   +  AR  E+  R Q   A + 
Sbjct: 884  QLQEQLQAETELCAEAEELRARLTAKKQE----LEEICHDLEARVEEEEERCQHLQAEKK 939

Query: 89   QMRQEIERLTERLEEKEREMQQL-LSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSL 147
            +M+Q I+ L E+LEE+E   Q+L L +   E + + +   + + E +  + A +   + L
Sbjct: 940  KMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEK--KLL 997

Query: 148  ANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQ 207
             +   +    LT      + LAK  ++                         +++I  L+
Sbjct: 998  EDRIAEFTTNLTEEEEKSKSLAKLKNKH------------------------EAMITDLE 1033

Query: 208  EENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQ 267
            E  R  +++   +E    K +  +    + +  L AQ+  L++    +L +KE       
Sbjct: 1034 ERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKM----QLAKKE------- 1082

Query: 268  LEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQEL 327
             EE     A V++E A     ++ AL++++ LE QI   ++D  SERA R +A+ + ++L
Sbjct: 1083 -EELQAALARVEEEAA----QKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDL 1137

Query: 328  EEKVASLLHQVSWRQDS 344
             E++ +L  ++    DS
Sbjct: 1138 GEELEALKTELEDTLDS 1154



 Score = 55.8 bits (133), Expect = 7e-08
 Identities = 81/383 (21%), Positives = 167/383 (43%), Gaps = 41/383 (10%)

Query: 2    SRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAP 61
            S+D       E  ++  AL     E   +L  L+D+L A +    RL   L A++     
Sbjct: 1512 SKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFER 1571

Query: 62   SLVDALLEQVARFREQLRRQEGGAAEAQMRQEIERLT------ERLEEKEREMQQLLSQP 115
             L     EQ    ++QL RQ     EA++  E ++ +      ++LE   ++++  +   
Sbjct: 1572 DL-QGRDEQSEEKKKQLVRQV-REMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSA 1629

Query: 116  QHEREKEVVLLRR-------SMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHL 168
               R++ +  LR+        M E +  RA+ + +         +L+        + + L
Sbjct: 1630 NKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEEL 1689

Query: 169  AKCLDERQHAQRNVGERSPDQSEHTDGHTS--------VQSVIEKLQEENRLLKQKVTHV 220
            A     ++ AQ+   E + D+  ++ G  +        +++ I +L+EE   L+++  + 
Sbjct: 1690 AAAERAKRQAQQERDELA-DEIANSSGKGALALEEKRRLEARIAQLEEE---LEEEQGNT 1745

Query: 221  EDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDC-AEVK 279
            E +N + ++ N   D+    L+ +    Q   + E  R+++ R N++L+ K+ +    VK
Sbjct: 1746 ELINDRLKKANLQIDQINTDLNLERSHAQ---KNENARQQLERQNKELKVKLQEMEGTVK 1802

Query: 280  QELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339
             +  AS TA +A   ++  LE+Q+        +E  +R+ A  +++  E+K+  +L QV 
Sbjct: 1803 SKYKASITALEA---KIAQLEEQL-------DNETKERQAACKQVRRTEKKLKDVLLQVD 1852

Query: 340  WRQDSREPDAGRIHAGSKTAKYL 362
              + + E    +    S   K L
Sbjct: 1853 DERRNAEQYKDQADKASTRLKQL 1875



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 66/293 (22%), Positives = 115/293 (39%), Gaps = 45/293 (15%)

Query: 68   LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124
            L QV+R  E++  +E    + + +Q       RL E E    QL++   Q Q + + E  
Sbjct: 837  LLQVSRQEEEMMAKEEELVKVREKQLAAE--NRLTEMETLQSQLMAEKLQLQEQLQAETE 894

Query: 125  LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184
            L     AE E  RA      + L    H L   +      CQHL     E++  Q+N+ E
Sbjct: 895  LC----AEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQA---EKKKMQQNIQE 947

Query: 185  RSPDQSEHTDGHTSVQSVIEKLQEENRL--LKQKVTHVEDLNAKWQRYNASRDEYVRGLH 242
                  E       +Q  +EK+  E +L  L+++   +ED N K                
Sbjct: 948  LEEQLEEEESARQKLQ--LEKVTTEAKLKKLEEEQIILEDQNCK---------------- 989

Query: 243  AQLRGLQIPHEPELMRKEISRLNRQL---EEKINDCAEVKQELAASRTARDAALERVQML 299
                   +  E +L+   I+     L   EEK    A++K +  A  T  +  L R +  
Sbjct: 990  -------LAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQ 1042

Query: 300  EQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRI 352
             Q++   +     +  D      +I EL+ ++A L  Q++ +++  +    R+
Sbjct: 1043 RQELEKTRRKLEGDSTD---LSDQIAELQAQIAELKMQLAKKEEELQAALARV 1092



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 51/273 (18%), Positives = 118/273 (43%), Gaps = 30/273 (10%)

Query: 101  LEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTA 160
            LE+K+++  QLL++       E  +  +   E +RA A              + R   T 
Sbjct: 1439 LEKKQKKFDQLLAE-------EKTISAKYAEERDRAEA--------------EAREKETK 1477

Query: 161  TAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKV--- 217
               + + L + ++++   +R   +   +  +       V   + +L++  R L+Q+V   
Sbjct: 1478 ALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEM 1537

Query: 218  -THVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCA 276
             T +E+L  + Q   A+ D  +R L   L+ ++   E +L  ++  +   + ++ +    
Sbjct: 1538 KTQLEELEDELQ---ATEDAKLR-LEVNLQAMKAQFERDLQGRD-EQSEEKKKQLVRQVR 1592

Query: 277  EVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
            E++ EL   R  R  A+   + LE  +   +    S   +R+ A  ++++L+ ++   + 
Sbjct: 1593 EMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMR 1652

Query: 337  QVSWRQDSREPDAGRIHAGSKTAKYLAADALEL 369
            ++   + SRE    +     K  K + A+ ++L
Sbjct: 1653 ELDDTRASREEILAQAKENEKKLKSMEAEMIQL 1685



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 89/410 (21%), Positives = 162/410 (39%), Gaps = 84/410 (20%)

Query: 31   LRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG------ 84
            L R++++ A ++  + ++R     LE   +    D   E+ +R + + ++++ G      
Sbjct: 1089 LARVEEEAAQKNMALKKIRE----LESQISELQEDLESERASRNKAEKQKRDLGEELEAL 1144

Query: 85   -----------AAEAQMR----QEIERLTERLEEKER-------EMQQLLSQPQHEREKE 122
                       AA+ ++R    QE+  L + LEE+ +       EM+Q  SQ   E  ++
Sbjct: 1145 KTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQ 1204

Query: 123  VVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNV 182
            +   +R  A  E+A+   +     LANE   L +    + H  + +   L E Q  + N 
Sbjct: 1205 LEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQ-VKFNE 1263

Query: 183  GER--------------------------SPDQSEHTDGHTSVQSVI----EKLQEENR- 211
            GER                              S+ T   ++++S +    E LQEENR 
Sbjct: 1264 GERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQ 1323

Query: 212  --LLKQKVTHVEDLNAKWQRYNASRDE-------YVRGLHAQLRGLQIPHEPELMRKEIS 262
               L  K+  VED    ++      +E        +  LHAQ+  ++   E  +   E +
Sbjct: 1324 KLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETA 1383

Query: 263  -RLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQ 321
              + R+L++ +   ++  +E  A+    +    R+Q     +L   D       + E+ Q
Sbjct: 1384 EEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQ 1443

Query: 322  SRIQEL--EEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLA-ADALE 368
             +  +L  EEK  S  +       + E D     A  K  K L+ A ALE
Sbjct: 1444 KKFDQLLAEEKTISAKY-------AEERDRAEAEAREKETKALSLARALE 1486



 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 64/317 (20%), Positives = 132/317 (41%), Gaps = 35/317 (11%)

Query: 36   DQLAARDALIA------RLRARLAALEGDA-APSLVDALLE------QVARFREQLR--- 79
            DQL A +  I+      R RA   A E +  A SL  AL E      ++ R  +Q R   
Sbjct: 1447 DQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEM 1506

Query: 80   ------RQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVL---LRRSM 130
                  + + G +  ++ +    L +++EE + ++++L  + Q   + ++ L   L+   
Sbjct: 1507 EDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMK 1566

Query: 131  AEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQS 190
            A+ ER     D        ++ + ++ L       +  A+  DER+     V  R   + 
Sbjct: 1567 AQFERDLQGRD-------EQSEEKKKQLVRQVREME--AELEDERKQRSMAVAARKKLEM 1617

Query: 191  EHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQ- 249
            +  D    + S  +   E  + L++    ++D   +     ASR+E +       + L+ 
Sbjct: 1618 DLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKS 1677

Query: 250  IPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDD 309
            +  E   +++E++   R   +   +  E+  E+A S      ALE  + LE +I   +++
Sbjct: 1678 MEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEE 1737

Query: 310  FMSERADRERAQSRIQE 326
               E+ + E    R+++
Sbjct: 1738 LEEEQGNTELINDRLKK 1754



 Score = 38.1 bits (87), Expect = 0.015
 Identities = 32/121 (26%), Positives = 60/121 (49%), Gaps = 6/121 (4%)

Query: 216 KVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKIND- 274
           KV  +  ++ + +   A  +E V+    QL       E E ++ ++     QL+E++   
Sbjct: 833 KVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAE 892

Query: 275 ---CAEVKQELAASRTARDAALERV-QMLEQQILAYKDDFMSERADRERAQSRIQELEEK 330
              CAE  +EL A  TA+   LE +   LE ++   ++     +A++++ Q  IQELEE+
Sbjct: 893 TELCAEA-EELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQ 951

Query: 331 V 331
           +
Sbjct: 952 L 952



 Score = 33.5 bits (75), Expect = 0.38
 Identities = 68/306 (22%), Positives = 120/306 (39%), Gaps = 49/306 (16%)

Query: 31   LRRLQDQLAARDALIARLRA---RLAALEGDAAPSLVDALLEQVARFREQLRRQE----- 82
            +R L D  A+R+ ++A+ +    +L ++E +      +    + A+ + Q  R E     
Sbjct: 1651 MRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEI 1710

Query: 83   -----GGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVL----------LR 127
                  GA   + ++ +E    +LEE E E +Q  ++  ++R K+  L          L 
Sbjct: 1711 ANSSGKGALALEEKRRLEARIAQLEE-ELEEEQGNTELINDRLKKANLQIDQINTDLNLE 1769

Query: 128  RSMAE-GERARAASDVLCRSLANETHQLRRT--------LTATAHMCQHLAKCLD----E 174
            RS A+  E AR   +   + L  +  ++  T        +TA       L + LD    E
Sbjct: 1770 RSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKE 1829

Query: 175  RQHAQRNVGERSPDQSEHT----DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRY 230
            RQ A + V        +      D   + +   ++  + +  LKQ    +E+   + QR 
Sbjct: 1830 RQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRA 1889

Query: 231  NASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARD 290
            NASR +  R L             + M +E+S L  +L     D   V     A + A D
Sbjct: 1890 NASRRKLQRELE------DATETADAMNREVSSLKNKLRR--GDLPFVVPRRMARKGAGD 1941

Query: 291  AALERV 296
             + E V
Sbjct: 1942 GSDEEV 1947


>gi|223671870 inhibitor of kappa light polypeptide gene enhancer in
           B-cells, kinase gamma isoform b [Homo sapiens]
          Length = 487

 Score = 62.4 bits (150), Expect = 8e-10
 Identities = 93/426 (21%), Positives = 164/426 (38%), Gaps = 61/426 (14%)

Query: 35  QDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAE------- 87
           QD L     L       L + +G  AP  +   LE+    R+ +R+      E       
Sbjct: 92  QDVLGEESPLGKPAMLHLPSEQG--APETLQRCLEENQELRDAIRQSNQILRERCEELLH 149

Query: 88  --AQMRQEIERLTERLEEKEREMQQL------LSQPQHEREKEVVLLRRSMAEGERARAA 139
             A  R+E E L  + +E  + +++L      L + + +  +EV  L+R   +    +A+
Sbjct: 150 FQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKAS 209

Query: 140 SDVLCRSLANETHQLRRTLTATAHMCQHL-AKCLDERQHAQRNVGERSPDQSEHTDGHTS 198
                 SL  E  + +  L A    CQ L  +     + A++   ER   Q +H+     
Sbjct: 210 VKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQ 269

Query: 199 V----QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGL---HAQLRGLQIP 251
           +    QSV   L+ E +   ++   +  L   + +     D +++       + RG+Q+ 
Sbjct: 270 LRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL- 328

Query: 252 HEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFM 311
                  +++ +  +Q EE +    EV  +L          +E V +L+ Q   YK DF 
Sbjct: 329 -------EDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQ 381

Query: 312 SERADRERAQSRIQELEEKVASLLHQ-----VSWRQDSREPDAGRIHAGSKTAKYLAADA 366
           +ER  RE+   + + L+E++  L  +      S ++ +R  D  + H     A    A A
Sbjct: 382 AERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPA 441

Query: 367 L---ELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPHCLQCFSDEQGEELLRH 423
                L +P        SQ+  PP E            D  CP C   +     + L  H
Sbjct: 442 YLSSPLALP--------SQRRSPPEE----------PPDFCCPKCQ--YQAPDMDTLQIH 481

Query: 424 VAECCQ 429
           V EC +
Sbjct: 482 VMECIE 487


>gi|4504631 inhibitor of kappa light polypeptide gene enhancer in
           B-cells, kinase gamma isoform a [Homo sapiens]
          Length = 419

 Score = 62.4 bits (150), Expect = 8e-10
 Identities = 93/426 (21%), Positives = 164/426 (38%), Gaps = 61/426 (14%)

Query: 35  QDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAE------- 87
           QD L     L       L + +G  AP  +   LE+    R+ +R+      E       
Sbjct: 24  QDVLGEESPLGKPAMLHLPSEQG--APETLQRCLEENQELRDAIRQSNQILRERCEELLH 81

Query: 88  --AQMRQEIERLTERLEEKEREMQQL------LSQPQHEREKEVVLLRRSMAEGERARAA 139
             A  R+E E L  + +E  + +++L      L + + +  +EV  L+R   +    +A+
Sbjct: 82  FQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKAS 141

Query: 140 SDVLCRSLANETHQLRRTLTATAHMCQHL-AKCLDERQHAQRNVGERSPDQSEHTDGHTS 198
                 SL  E  + +  L A    CQ L  +     + A++   ER   Q +H+     
Sbjct: 142 VKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQ 201

Query: 199 V----QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGL---HAQLRGLQIP 251
           +    QSV   L+ E +   ++   +  L   + +     D +++       + RG+Q+ 
Sbjct: 202 LRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL- 260

Query: 252 HEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFM 311
                  +++ +  +Q EE +    EV  +L          +E V +L+ Q   YK DF 
Sbjct: 261 -------EDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQ 313

Query: 312 SERADRERAQSRIQELEEKVASLLHQ-----VSWRQDSREPDAGRIHAGSKTAKYLAADA 366
           +ER  RE+   + + L+E++  L  +      S ++ +R  D  + H     A    A A
Sbjct: 314 AERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPA 373

Query: 367 L---ELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPHCLQCFSDEQGEELLRH 423
                L +P        SQ+  PP E            D  CP C   +     + L  H
Sbjct: 374 YLSSPLALP--------SQRRSPPEE----------PPDFCCPKCQ--YQAPDMDTLQIH 413

Query: 424 VAECCQ 429
           V EC +
Sbjct: 414 VMECIE 419


>gi|153792133 inhibitor of kappa light polypeptide gene enhancer in
           B-cells, kinase gamma isoform a [Homo sapiens]
          Length = 419

 Score = 62.4 bits (150), Expect = 8e-10
 Identities = 93/426 (21%), Positives = 164/426 (38%), Gaps = 61/426 (14%)

Query: 35  QDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAE------- 87
           QD L     L       L + +G  AP  +   LE+    R+ +R+      E       
Sbjct: 24  QDVLGEESPLGKPAMLHLPSEQG--APETLQRCLEENQELRDAIRQSNQILRERCEELLH 81

Query: 88  --AQMRQEIERLTERLEEKEREMQQL------LSQPQHEREKEVVLLRRSMAEGERARAA 139
             A  R+E E L  + +E  + +++L      L + + +  +EV  L+R   +    +A+
Sbjct: 82  FQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKAS 141

Query: 140 SDVLCRSLANETHQLRRTLTATAHMCQHL-AKCLDERQHAQRNVGERSPDQSEHTDGHTS 198
                 SL  E  + +  L A    CQ L  +     + A++   ER   Q +H+     
Sbjct: 142 VKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQ 201

Query: 199 V----QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGL---HAQLRGLQIP 251
           +    QSV   L+ E +   ++   +  L   + +     D +++       + RG+Q+ 
Sbjct: 202 LRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL- 260

Query: 252 HEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFM 311
                  +++ +  +Q EE +    EV  +L          +E V +L+ Q   YK DF 
Sbjct: 261 -------EDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQ 313

Query: 312 SERADRERAQSRIQELEEKVASLLHQ-----VSWRQDSREPDAGRIHAGSKTAKYLAADA 366
           +ER  RE+   + + L+E++  L  +      S ++ +R  D  + H     A    A A
Sbjct: 314 AERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPA 373

Query: 367 L---ELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPHCLQCFSDEQGEELLRH 423
                L +P        SQ+  PP E            D  CP C   +     + L  H
Sbjct: 374 YLSSPLALP--------SQRRSPPEE----------PPDFCCPKCQ--YQAPDMDTLQIH 413

Query: 424 VAECCQ 429
           V EC +
Sbjct: 414 VMECIE 419


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 90/428 (21%), Positives = 174/428 (40%), Gaps = 84/428 (19%)

Query: 8   GGWEEAPRAAAALCTLYHEAGQRLRRLQDQLA-ARDALIARLRARLAALEGDAAP----- 61
           G +EE  +  ++L T    +   L + +++L  A  A  ARL A++A+L  +        
Sbjct: 455 GHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATI 514

Query: 62  --------SLVDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS 113
                    L     E+ A+  + L++QE   A   +R ++E+L+  L++KE++++++  
Sbjct: 515 QQQDQELAGLKQQAKEKQAQLAQTLQQQE--QASQGLRHQVEQLSSSLKQKEQQLKEVAE 572

Query: 114 QPQHEREKEVVLLRRSMAEGERARAASDVLCRSL--------------------ANETH- 152
           + +  R+     L  +  E E +    D   + L                    ANE   
Sbjct: 573 KQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARD 632

Query: 153 -------QLRRTLTATAHMCQHLAKCLD----ERQHAQRNVGERS----PDQSEHTDGHT 197
                  Q +R     +   + L  C++    E+  AQ  V E       +Q + T+   
Sbjct: 633 SAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKER 692

Query: 198 SVQSVIEKLQEENRLLKQ--KVTHVEDLNAKWQRYNASRDEY--VRGLHAQLRGLQIPHE 253
             Q   ++LQE+ + LK+  KVT       K +  +A  ++   +  L A+ R L   H+
Sbjct: 693 VAQEK-DQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHK 751

Query: 254 PELMRKEISRLNRQ-LEEKINDCAEVKQ--------ELAASRTARDAALERVQMLEQQIL 304
            E    E  R  R+ LE ++    E  Q        ELA +  A+  A    + L +++ 
Sbjct: 752 RERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVA 811

Query: 305 AYKDDF------------------MSERADRERAQSRIQELEEKVASLLHQVSWRQDSRE 346
           A+++ +                  M+ + + E+A+  +QE +EKVA +      +   ++
Sbjct: 812 AWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQ 871

Query: 347 PDAGRIHA 354
            +   +HA
Sbjct: 872 NELAELHA 879



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 84/347 (24%), Positives = 136/347 (39%), Gaps = 46/347 (13%)

Query: 31   LRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQ----LRRQEGG-- 84
            L  LQ+++AA    +ARL   L    G+   +    L+++ AR  ++    L  Q+G   
Sbjct: 902  LSTLQEKMAATSKEVARLET-LVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQF 960

Query: 85   ----AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHER---EKEVVLLRRS-------M 130
                AA   M +E E++   LE     + +   Q Q ER   E+EV  L +        +
Sbjct: 961  CSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADL 1020

Query: 131  AEGERARAASDVLCRSLANETH--------QLRRTLTATAHMCQHLAKC----------L 172
            A  + ARA  ++  ++  NE           L   LT      Q LAK           L
Sbjct: 1021 ALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKEL 1080

Query: 173  DERQHAQRNVGER-SPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYN 231
            +E +   + + E+ +  + EH  G  +      + +     L+     V  L  + Q+  
Sbjct: 1081 EELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQ 1140

Query: 232  ASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDA 291
               D   R L A+ R  +   +  L       L  QLEEK  +    +  LA+++    A
Sbjct: 1141 EQADSLERSLEAE-RASRAERDSAL-----ETLQGQLEEKAQELGHSQSALASAQRELAA 1194

Query: 292  ALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV 338
               +VQ   +    +K      R + ER  S I  LEE+V+ L  QV
Sbjct: 1195 FRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQV 1241



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 70/295 (23%), Positives = 126/295 (42%), Gaps = 34/295 (11%)

Query: 52   LAALEGDAAPSL--VDALLEQVARFREQLRRQE-----GGAAEAQMRQEIERLTERLEEK 104
            LA L G  A  +  ++ L + V + +EQL ++E     G  A+++     E    +LE  
Sbjct: 1066 LAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEAL 1125

Query: 105  EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAAS-----DVLCRSLANETHQLRRTLT 159
              E+ +L  Q Q ++E +   L RS+ E ERA  A      + L   L  +  +L  + +
Sbjct: 1126 RAEVSKLEQQCQKQQE-QADSLERSL-EAERASRAERDSALETLQGQLEEKAQELGHSQS 1183

Query: 160  ATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTH 219
            A A   + LA    + Q   +   E     +          S+I  L+EE  +L ++V  
Sbjct: 1184 ALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLE 1243

Query: 220  VEDLNAKWQRYNASRDEYVRGLHAQLRGLQIP---------HEPELMRKEISRLNRQLEE 270
             E  + + +R   +  E  + L  +LR LQ                +R+E+  L  + E+
Sbjct: 1244 KEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEK 1303

Query: 271  KINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQ 325
            +      ++QEL +         ER + L Q++ A+++ F      +E+A S +Q
Sbjct: 1304 QRVASENLRQELTSQ-------AERAEELGQELKAWQEKFF----QKEQALSTLQ 1347



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 83/362 (22%), Positives = 142/362 (39%), Gaps = 34/362 (9%)

Query: 11  EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRA-------RLAALEGDAAPSL 63
           E   + AA L     +   R+  L+ +   ++A +   R        +L++L  D   S+
Sbjct: 416 ETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSI 475

Query: 64  VDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEV 123
            +  L Q     EQ  +  G    AQ+      LT      +++ Q+L    Q  +EK+ 
Sbjct: 476 SN--LSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQA 533

Query: 124 VL---LRRSMAEGERARAASDVLCRSLANETHQL-----RRTLTATAHMCQHLAKCLDER 175
            L   L++     +  R   + L  SL  +  QL     ++  T   H  Q LA   +ER
Sbjct: 534 QLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDH-AQQLATAAEER 592

Query: 176 QHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRD 235
           + + R   ER     +         + +E LQ++ ++  +     +    + QR  A   
Sbjct: 593 EASLR---ERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELS 649

Query: 236 EYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALE 294
             V  L A +    Q  HE +    E+    R  ++K  +   V QE       +D   E
Sbjct: 650 RKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQE-------KDQLQE 702

Query: 295 RVQMLEQQILAYKDDFMSER---ADRERAQSR-IQELEEKVASLLHQ-VSWRQDSREPDA 349
           ++Q L++ +   K     E+   AD    Q R I EL+ +  SL+ Q    R++  E  A
Sbjct: 703 QLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERA 762

Query: 350 GR 351
           GR
Sbjct: 763 GR 764



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 73/354 (20%), Positives = 144/354 (40%), Gaps = 50/354 (14%)

Query: 30   RLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFRE------QLRRQEG 83
            RL++L +   A   ++ R  A   A +   A S  + L+++VA +RE      Q   Q G
Sbjct: 770  RLQQLGEAHQAETEVLRRELAEAMAAQ-HTAESECEQLVKEVAAWRERYEDSQQEEAQYG 828

Query: 84   GAAEAQM----------RQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG 133
               + Q+          RQE++   E++   E   +  +S+ Q+E  +    L R++ + 
Sbjct: 829  AMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQV 888

Query: 134  ERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNV-------GERS 186
            +     +  L   L+    ++  T    A +   + K  ++++ A R +       G+R 
Sbjct: 889  QEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQ 948

Query: 187  PDQSEHTDGH--TSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQ 244
            P+  E   G    S Q+ ++ ++ E           E +  + +R  A+  E  +G   +
Sbjct: 949  PEWLEEQQGRQFCSTQAALQAMERE----------AEQMGNELERLRAALME-SQGQQQE 997

Query: 245  LRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQIL 304
             RG Q   E E+ R    R   Q +  +   A  + E+       +  +E   +  Q+ L
Sbjct: 998  ERGQQ---EREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATL--QEAL 1052

Query: 305  AY-------KDDFMSERADRERAQ-SRIQELEEKVASLLHQVSWRQDSREPDAG 350
            A+       KD  +++    E AQ   ++EL + V  L  Q++ ++      +G
Sbjct: 1053 AHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSG 1106



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 87/371 (23%), Positives = 146/371 (39%), Gaps = 45/371 (12%)

Query: 18   AALCTLYHEA---GQRLRRLQDQLAARDALIARLRAR----LAALEGDAAPSLVDALLEQ 70
            AAL  +  EA   G  L RL+  L          R +    +A L  +   +  D  LE+
Sbjct: 965  AALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEK 1024

Query: 71   VARFREQLRRQEG-GAAEAQMRQEIERLTERLEEKEREMQQLLS---------QPQHERE 120
             AR   ++R Q        +     E L   L EKE + Q+L           +   E  
Sbjct: 1025 AARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELR 1084

Query: 121  KEVVLLRRSMAEGERARAASDVLCRSLANETHQ-------LRRTLTATAHMCQHLAKCLD 173
            + V  L+  +A+ E+  A+        A  T         LR  ++     CQ   K  +
Sbjct: 1085 QTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQ---KQQE 1141

Query: 174  ERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEE----NRLLKQKVTHVEDLNAKWQR 229
            +    +R++      ++E      ++Q  +E+  +E       L      +     K Q 
Sbjct: 1142 QADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQD 1201

Query: 230  YNASRDEYVRGLHAQL-RGLQIPHEPELM----RKEISRLNRQLEEKINDCAEVKQELAA 284
            ++ + DE+     AQ+ RG Q       +     +E+S LNRQ+ EK  +  E+K+ + A
Sbjct: 1202 HSKAEDEW----KAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMA 1257

Query: 285  SRTARDAALERVQMLEQQILAYKDDFMSERAD--RERAQSRIQELE-EKVAS-LLHQVSW 340
                     ER+++L+ +  A      +ER+   RE  QS  +E E ++VAS  L Q   
Sbjct: 1258 ESEKSQKLEERLRLLQAE-TASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELT 1316

Query: 341  RQDSREPDAGR 351
             Q  R  + G+
Sbjct: 1317 SQAERAEELGQ 1327



 Score = 38.1 bits (87), Expect = 0.015
 Identities = 77/353 (21%), Positives = 139/353 (39%), Gaps = 43/353 (12%)

Query: 25  HEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLE---QVARFREQLRRQ 81
           H+A + +R L+ Q  A  +           L G  A  + D L     Q+ R ++QL  +
Sbjct: 173 HQAKREIRFLELQKVASSSSGNNF------LSGSPASPMGDILQTPQFQMRRLKKQLADE 226

Query: 82  EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASD 141
                E ++  E+    + L EK+ ++  +      +R   + LL    A    A     
Sbjct: 227 RSNRDELEL--ELAENRKLLTEKDAQIAMM-----QQRIDRLALLNEKQA----ASPLEP 275

Query: 142 VLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQS----EHTDGHT 197
                L ++   L   L  T   CQ L     +       + E + D S    E      
Sbjct: 276 KELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQ 335

Query: 198 SVQSVIEKLQEEN-----RLLKQKVTHVEDLNAKWQRYNA--SRDEYVRGLHAQLRG--L 248
            +Q  + +L EE+       L+++    ++L+A  Q       ++E ++G  +QL     
Sbjct: 336 QLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLS 395

Query: 249 QIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALE-RVQMLEQQILAYK 307
           Q+   P   + E+     QLE        +KQE AA+  A +  L+ RV+MLE +    +
Sbjct: 396 QLQDNPPQEKGEVLGDVLQLET-------LKQE-AATLAANNTQLQARVEMLETERGQQE 447

Query: 308 DDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360
              ++ER   E  + ++  L   + S +  +S  ++  E  A + H    TA+
Sbjct: 448 AKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELE-QASQAHGARLTAQ 499



 Score = 28.9 bits (63), Expect = 9.4
 Identities = 40/186 (21%), Positives = 72/186 (38%), Gaps = 29/186 (15%)

Query: 26   EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDA--LLEQVARFREQLRRQEG 83
            E  +++  L  +LA  D      + +L A++     S  +A  L  Q+   + QL ++E 
Sbjct: 1546 EQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQ 1605

Query: 84   GA---------------AEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRR 128
             A               A+ Q  QE++     LE+ ++E ++L ++ +         L  
Sbjct: 1606 AAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAER--------LGH 1657

Query: 129  SMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPD 188
             + +       ++  CR L   T Q+R      AH  Q L + L + Q A   +  R P 
Sbjct: 1658 ELQQAGLKTKEAEQTCRHL---TAQVRSLEAQVAHADQQL-RDLGKFQVATDALKSREPQ 1713

Query: 189  QSEHTD 194
                 D
Sbjct: 1714 AKPQLD 1719


>gi|126723390 ankyrin repeat domain 24 [Homo sapiens]
          Length = 1146

 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 83/358 (23%), Positives = 147/358 (41%), Gaps = 56/358 (15%)

Query: 14   PRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVAR 73
            P AA A   L  E   R+R L++ L        R R R AA E +AA    +A   +  R
Sbjct: 712  PGAAEASEKLQVELETRIRGLEEAL--------RQREREAAAELEAALGKCEAAEAEAGR 763

Query: 74   FREQLRRQEGGAAE-------AQMRQEIERLTERLEEKEREMQQL------LSQPQHER- 119
             RE++R  EG  A         Q+R  +E+  E L +++  +++L      L + +  R 
Sbjct: 764  LRERVREAEGSGASGGGGGDTTQLRAALEQAREDLRDRDSRLRELEAASACLDEARASRL 823

Query: 120  --EKEVVLLRRSMAEGERARAAS----DVLCRSLANETHQLRRTLTATAHMCQHLAKCLD 173
              E+E   LR  +A+ E AR       +VL   LA       +  TA A + +       
Sbjct: 824  LAEEEARGLRAELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGR------- 876

Query: 174  ERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQE------ENRLLKQKVTHVEDLNAKW 227
             R  A+  V E      E   G   ++   E L++      E+R L+++   +    A  
Sbjct: 877  ARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASL 936

Query: 228  QRYNASRDEYVRGLHAQLRGLQI------PHEPEL---------MRKEISRLNRQLEEKI 272
            ++   +  +    L A+L   ++       HE  +         +  ++  L R+ E+  
Sbjct: 937  EQEVVATGKEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTS 996

Query: 273  NDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEK 330
             +  +V++E    ++ R AA  ++   EQQ+   + +    R  + RAQ  + + +EK
Sbjct: 997  AEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEK 1054



 Score = 36.2 bits (82), Expect = 0.059
 Identities = 81/368 (22%), Positives = 135/368 (36%), Gaps = 79/368 (21%)

Query: 67  LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHE-----REK 121
           LL+++    +   R++  + EA     +ER  +       E+QQLL + Q E     RE 
Sbjct: 336 LLQKIRGLEQHKERRQQESPEASSLHILERQVQ-------ELQQLLVERQEEKESLGREV 388

Query: 122 EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRN 181
           E +  R S+ E ER   + DV   +L +E  +L     A   + + L             
Sbjct: 389 ESLQSRLSLLENERENTSYDV--TTLQDEEGELPDLPGAEVLLSRQL------------- 433

Query: 182 VGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQR------------ 229
               SP   EH     S+Q  +  L  +N+ L +KV  +E+      +            
Sbjct: 434 ----SPSAQEHL---ASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIPL 486

Query: 230 --YNASRDEY--VRGLHAQ-LRGLQIPHEPELMRKEIS--------------------RL 264
             Y++ R E+  +R  HA+ L+ L+     E+ R+E +                     L
Sbjct: 487 ALYDSLRAEFDQLRRQHAEALQALRQQETREVPREEGAACGESEVAGATATKNGPTHMEL 546

Query: 265 NRQL--EEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQS 322
           N  +  E K+N    + +E A   T     +E      +   A              A+ 
Sbjct: 547 NGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGAEV 606

Query: 323 RIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALELMVPGGWRPGTGSQ 382
           R  E  E+ A++  + +  Q +     G    G +  K  A +A E+        G G+ 
Sbjct: 607 REMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEA-EMQA-----YGVGAG 660

Query: 383 QPEPPAEG 390
           Q EPP  G
Sbjct: 661 QAEPPVTG 668


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 66/322 (20%), Positives = 148/322 (45%), Gaps = 33/322 (10%)

Query: 30   RLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ-----EGG 84
            ++ R +++L A+D  + +++ +   +EG+         LE++ R  +QL  +     E  
Sbjct: 846  QVTRQEEELQAKDEELLKVKEKQTKVEGE---------LEEMERKHQQLLEEKNILAEQL 896

Query: 85   AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLC 144
             AE ++  E E +  RL  K++E++++L   +   E+E    +    E ++ +A    L 
Sbjct: 897  QAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLE 956

Query: 145  RSL-----ANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV 199
              L     A +  QL + +TA A + +   + L       + + E+   +    +  + +
Sbjct: 957  EQLDEEEGARQKLQLEK-VTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQL 1015

Query: 200  QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259
                EK +   ++  ++   + DL  + ++   +R E  +         ++  E   ++ 
Sbjct: 1016 AEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKR------KLDGETTDLQD 1069

Query: 260  EISRLNRQLEEKINDCAEVKQELAASRTARDA-------ALERVQMLEQQILAYKDDFMS 312
            +I+ L  Q++E     A+ ++EL  +    D        AL+ V+ L+ QI   ++DF S
Sbjct: 1070 QIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFES 1129

Query: 313  ERADRERAQSRIQELEEKVASL 334
            E+A R +A+ + ++L E++ +L
Sbjct: 1130 EKASRNKAEKQKRDLSEELEAL 1151



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 83/405 (20%), Positives = 172/405 (42%), Gaps = 49/405 (12%)

Query: 2    SRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAP 61
            S+D       E  ++  AL     E   +L  L+D+L A +    RL   + A++     
Sbjct: 1519 SKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER 1578

Query: 62   SLVDA----------LLEQVARFREQL---RRQEGGAAEAQMRQEIER--LTERLEEKER 106
             L             L++QV     +L   R+Q   A  ++ + EI+   L  ++E   +
Sbjct: 1579 DLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANK 1638

Query: 107  EMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQ 166
               +++ Q +    K    ++    E E ARA+ D +         +L+        + +
Sbjct: 1639 ARDEVIKQLR----KLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQE 1694

Query: 167  HLAKCLDERQHAQRNVGERSPDQSEHTDGHTS-------VQSVIEKLQEENRLLKQKVTH 219
             LA     R+HA++   E + + +    G ++       +++ I +L+EE   L+++ ++
Sbjct: 1695 ELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEE---LEEEQSN 1751

Query: 220  VEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDC-AEV 278
            +E LN ++++     D     L A+    Q   + +  R+++ R N++L+ K+ +    V
Sbjct: 1752 MELLNDRFRKTTLQVDTLNAELAAERSAAQ---KSDNARQQLERQNKELKAKLQELEGAV 1808

Query: 279  KQELAASRTARDAALERV-QMLEQQI--------------LAYKDDFMSERADRERAQSR 323
            K +  A+ +A +A + ++ + LEQ+                  K+ FM    +R  A  +
Sbjct: 1809 KSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHA-DQ 1867

Query: 324  IQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368
             +E  EK  + + Q+  + +  E +A R +A  +  +    DA E
Sbjct: 1868 YKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATE 1912



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 72/371 (19%), Positives = 153/371 (41%), Gaps = 71/371 (19%)

Query: 30   RLRRLQDQLAARDAL---IARLRARLAALEGDAAPSLVDALLEQVARFREQL----RRQE 82
            R+     QLA  +     +A++R +   +  D     ++  L++  + R++L    R+ +
Sbjct: 1007 RIAECSSQLAEEEEKAKNLAKIRNKQEVMISD-----LEERLKKEEKTRQELEKAKRKLD 1061

Query: 83   GGAAE-----AQMRQEIERLTERLEEKEREMQQLLSQPQHER-------------EKEVV 124
            G   +     A+++ +I+ L  +L +KE E+Q  L++   E              + ++ 
Sbjct: 1062 GETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIA 1121

Query: 125  LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184
             L+      + +R  ++   R L+ E   L+  L  T       A   + R   ++ V E
Sbjct: 1122 ELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTT---AAQQELRTKREQEVAE 1178

Query: 185  RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQ---RYNASRDEYVRGL 241
                  E T  H   ++ I+ +++ +       T +E+L+ + +   R+ A+ ++  +GL
Sbjct: 1179 LKKALEEETKNH---EAQIQDMRQRH------ATALEELSEQLEQAKRFKANLEKNKQGL 1229

Query: 242  HAQLRGL--------QIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAAL 293
                + L        Q+  E E  RK++    ++L  K+++   ++ ELA   +     L
Sbjct: 1230 ETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNEL 1289

Query: 294  ERVQ------------------MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLL 335
            + V                    LE Q+   ++    E   +    SRI++LEE+  SL 
Sbjct: 1290 DNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQ 1349

Query: 336  HQVSWRQDSRE 346
             Q    +++R+
Sbjct: 1350 EQQEEEEEARK 1360



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 86/380 (22%), Positives = 149/380 (39%), Gaps = 54/380 (14%)

Query: 34   LQDQLAARDALIARLRARLAALEGDAAPSL----------------VDALLEQVARFREQ 77
            LQDQ+A   A I  L+ +LA  E +   +L                V  L  Q+A  +E 
Sbjct: 1067 LQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQED 1126

Query: 78   LRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS------QPQHEREKEVVLLRRSMA 131
               ++    +A+ ++    L+E LE  + E++  L       + + +RE+EV  L++++ 
Sbjct: 1127 FESEKASRNKAEKQKR--DLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALE 1184

Query: 132  EGERARAASDVLCRSL-ANETHQLRRTLTATAHMCQHLAKC-----LDERQHA-QRNVGE 184
            E  +   A     R   A    +L   L        +L K       D ++ A +  V +
Sbjct: 1185 EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQ 1244

Query: 185  RSPDQSEHTDGH--TSVQSVIEKLQEENRL----------LKQKVTHVEDLNAKWQRYNA 232
            +   +SEH        VQ +  K+ E +RL          L+ ++ +V  L  + ++   
Sbjct: 1245 QVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGI 1304

Query: 233  SRDEYVRGLHAQLRGLQIPHEPELMRK-EISRLNRQLEEKINDCAEVKQELAASRTARDA 291
               +    L +QL+  Q   + E  +K  +S   RQLEE+ N   E ++E   +R     
Sbjct: 1305 KFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEAR----- 1359

Query: 292  ALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGR 351
                 + LE+Q+LA +      +   +     I+ LEE    LL          E  A  
Sbjct: 1360 -----KNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALA 1414

Query: 352  IHAGSKTAKYLAADALELMV 371
                 KT   L  +  +L V
Sbjct: 1415 YDKLEKTKNRLQQELDDLTV 1434



 Score = 37.7 bits (86), Expect = 0.020
 Identities = 71/349 (20%), Positives = 132/349 (37%), Gaps = 63/349 (18%)

Query: 26   EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85
            E  ++  +LQ++L     L+     +      DAA SL   L +     +E+ R++   +
Sbjct: 1277 ELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAA-SLESQLQDTQELLQEETRQKLNLS 1335

Query: 86   AEA-QMRQEIERLTERLEEKER-----EMQQLLSQPQ------------------HEREK 121
            +   Q+ +E   L E+ EE+E      E Q L  Q Q                   E +K
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395

Query: 122  EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQH---- 177
            +++    ++++    +A +        N   Q    LT      + +A  L+++Q     
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455

Query: 178  --------AQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQR 229
                    + R   ER   ++E  +  T   S+   L+E     ++     + L A  + 
Sbjct: 1456 LLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMED 1515

Query: 230  YNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR 289
              +S+D+  + +H              + K    L +Q+EE      E++ EL A+  A+
Sbjct: 1516 LMSSKDDVGKNVHE-------------LEKSKRALEQQVEEMRTQLEELEDELQATEDAK 1562

Query: 290  DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV 338
                     LE  + A K  F  +       Q+R ++ EEK   L+ QV
Sbjct: 1563 -------LRLEVNMQAMKAQFERD------LQTRDEQNEEKKRLLIKQV 1598



 Score = 33.5 bits (75), Expect = 0.38
 Identities = 34/148 (22%), Positives = 74/148 (50%), Gaps = 5/148 (3%)

Query: 197 TSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRG-LQIPHEPE 255
           T  +  ++   EE   +K+K T VE    + +R +    E    L  QL+   ++  E E
Sbjct: 848 TRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAE 907

Query: 256 LMRKEISRLNRQLEEKINDC-AEVKQELAASRTARDAALE---RVQMLEQQILAYKDDFM 311
            MR  ++   ++LEE ++D  + V++E   ++  ++   +    +Q LE+Q+   +    
Sbjct: 908 EMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQ 967

Query: 312 SERADRERAQSRIQELEEKVASLLHQVS 339
             + ++  A+++I+++EE++  L  Q S
Sbjct: 968 KLQLEKVTAEAKIKKMEEEILLLEDQNS 995



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 42/205 (20%), Positives = 81/205 (39%), Gaps = 42/205 (20%)

Query: 64   VDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEV 123
            VD L  ++A  R   ++ +   A  Q+ ++ + L  +L+E E  ++          E ++
Sbjct: 1766 VDTLNAELAAERSAAQKSDN--ARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKI 1823

Query: 124  VLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG 183
              L   + +  + RAA++ L R    +  ++               +  DER+HA     
Sbjct: 1824 GQLEEQLEQEAKERAAANKLVRRTEKKLKEI-------------FMQVEDERRHA----- 1865

Query: 184  ERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHA 243
                DQ +            E++++ N  +KQ    +E+   +  R NASR +  R L  
Sbjct: 1866 ----DQYK------------EQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELD- 1908

Query: 244  QLRGLQIPHEPELMRKEISRLNRQL 268
                       E + +E+S L  +L
Sbjct: 1909 -----DATEANEGLSREVSTLKNRL 1928


>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
          Length = 2325

 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 76/349 (21%), Positives = 146/349 (41%), Gaps = 44/349 (12%)

Query: 24  YHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEG 83
           Y +   RL  +  ++A     I  L  +L   +  A  +L   L   ++  +E L   +G
Sbjct: 571 YQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKG 630

Query: 84  GAAEAQ-----MRQEIERLTERLEEKEREMQQL--LSQPQHEREKEVVLLRRSMAEGERA 136
            A +AQ     +R E E L +RL E E+E  QL  ++       KE+  L  ++ E    
Sbjct: 631 QATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEV 690

Query: 137 RAASDVLCRSLAN--------------ETHQLRRTLTATAHMCQ----HLAKCLDERQHA 178
            A+       L+               E +QL+  L     + Q     L   L++ + A
Sbjct: 691 NASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQA 750

Query: 179 QRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQK-------VTHVEDLNAKWQRYN 231
            +N   ++    E    ++ + + ++ LQ++N LLKQ+       + HV D   + +   
Sbjct: 751 LKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVA 810

Query: 232 ASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDA 291
           A  DE  R L      + I    +++ K ++ L +Q  E +   A  K E   ++     
Sbjct: 811 ARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEIL---ARSKWERDEAQVRERK 867

Query: 292 ALERVQMLEQQILAYKDDFMS--ERA-------DRERAQSRIQELEEKV 331
             E + + ++++   +++F    ERA       D+ + ++RIQ++E ++
Sbjct: 868 LQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEI 916



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 76/321 (23%), Positives = 139/321 (43%), Gaps = 47/321 (14%)

Query: 35   QDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAE-AQMRQE 93
            Q ++A  D  +   +  L  L+G        ++++  A  +E LR  E    E     +E
Sbjct: 1593 QQEMAVLDRQLGHKKEELHLLQG--------SMVQAKADLQEALRLGETEVTEKCNHIRE 1644

Query: 94   IERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQ 153
            ++ L E L  ++ E+   +S    ER+ ++ L+++ +   E+      V+ R ++    +
Sbjct: 1645 VKSLLEELSFQKGELNVQIS----ERKTQLTLIKQEI---EKEEENLQVVLRQMSKHKTE 1697

Query: 154  LRRTLTATA---HMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEEN 210
            L+  L       H  Q L     + QH QR V E            T V  + EKL+ EN
Sbjct: 1698 LKNILDMLQLENHELQGL-----KLQHDQR-VSELEK---------TQVAVLEEKLELEN 1742

Query: 211  RLLKQKVTHVEDLNAKWQRYNASRDEY-VRGLHAQLRGLQIPHEPELMRKEISRLNRQLE 269
                Q+++  +    +WQ+    RD+  +  + A+ R LQ     E + KE   L  + +
Sbjct: 1743 L---QQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSC--VECLSKEKEDLQEKCD 1797

Query: 270  EKINDCAEVKQELAASRT---ARDAALERVQM----LEQQILAYKDDFMSERADRERAQS 322
                  A+ K+ LAA+        + LE++++    L+Q++     D +S   D    Q 
Sbjct: 1798 IWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQ 1857

Query: 323  RIQELEEKVASLLHQVSWRQD 343
            ++QE  E V SL  +++  QD
Sbjct: 1858 QLQEKREAVNSLQEELANVQD 1878



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 69/340 (20%), Positives = 136/340 (40%), Gaps = 31/340 (9%)

Query: 11   EEAPRAAAALCTLYHEAGQRLRRLQ-------DQLAARDALIARLRARLAALEGD--AAP 61
            EE  R A        +A Q+LR LQ            ++ ++  +   +AA + D     
Sbjct: 1478 EELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLS 1537

Query: 62   SLVDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREK 121
               + L E++ + ++ +   E    E    Q ++     L+ K  E+++L SQ   ++++
Sbjct: 1538 KKKEKLTEELQKLQKDIEMAERN--EDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQE 1595

Query: 122  EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRN 181
              VL R+   + E        + ++ A+    LR   T     C H+ +     +     
Sbjct: 1596 MAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQ 1655

Query: 182  VGERSPDQSEHTDGHTSVQSVIEKLQEENR--LLKQKVTHVEDLNAKWQRYNASRDEYVR 239
             GE +   SE     T ++  IEK +EEN   +L+Q   H  +L            E   
Sbjct: 1656 KGELNVQISERKTQLTLIKQEIEK-EEENLQVVLRQMSKHKTELKNILDMLQLENHE--- 1711

Query: 240  GLHAQLRGLQIPHE---PELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALER- 295
                 L+GL++ H+    EL + +++ L  +LE  + +  ++ Q+       +   LER 
Sbjct: 1712 -----LQGLKLQHDQRVSELEKTQVAVLEEKLE--LENLQQISQQQKGEIEWQKQLLERD 1764

Query: 296  ---VQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVA 332
               ++ +  +  A +        ++E  Q +    E+K+A
Sbjct: 1765 KREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLA 1804



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 85/380 (22%), Positives = 157/380 (41%), Gaps = 56/380 (14%)

Query: 26   EAGQRLRRLQDQLAARDALIAR---------LRARLAALEGDAAP--SLVDALLEQVARF 74
            EA  R R+LQ+++A +   +A           RA  A +  D     + +  +  ++   
Sbjct: 860  EAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYL 919

Query: 75   REQLRRQEG--GAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAE 132
            +E L+  E   G  + Q+ QE +   ER+  + RE+++       + +++V  L + + +
Sbjct: 920  QENLKSMEEIQGLTDLQL-QEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKK 978

Query: 133  GERARAASDVLCRS-LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSE 191
             ++A A SD L  + L     QL+        + Q  A+ L E +   R   + + D   
Sbjct: 979  LKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDL-- 1036

Query: 192  HTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIP 251
                 T  ++ IE LQ    LL+QK         +  R    +     G ++Q+  ++  
Sbjct: 1037 -----TRAEAEIELLQ---NLLRQK--------GEQFRLEMEKTGVGTGANSQVLEIEKL 1080

Query: 252  HEP-ELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDF 310
            +E  E  R EI+RL   L+   +D          ++   +  LE +  L +++ +Y++D+
Sbjct: 1081 NETMERQRTEIARLQNVLDLTGSD----------NKGGFENVLEEIAELRREV-SYQNDY 1129

Query: 311  MSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALELM 370
            +S  AD  + +     +    +S   +VS        D+G         KY A+  +   
Sbjct: 1130 ISSMADPFKRRGYWYFMPPPPSS---KVSSHSSQATKDSG------VGLKYSASTPVRKP 1180

Query: 371  VPGGWRPGTGSQQPEPPAEG 390
             PG      GSQ   PPA G
Sbjct: 1181 RPGQQDGKEGSQ--PPPASG 1198



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 62/280 (22%), Positives = 112/280 (40%), Gaps = 30/280 (10%)

Query: 77   QLRRQEGGAAEAQMRQEIERLTER----LEEKER--EMQQLLSQPQHEREKEVVLLRRSM 130
            QL   E    + Q  Q +  L +     LEEK     +QQ+  Q + E E +  LL R  
Sbjct: 1706 QLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDK 1765

Query: 131  AEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQS 190
             E ER  A S    R+L +    L +        C    K L + +       E S  + 
Sbjct: 1766 REIERMTAES----RALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQ 1821

Query: 191  EHTDGHTSVQSVIEKLQEE-NRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQ 249
             + +    ++  + KLQ+E ++L + K++   D++A  Q+    R E V  L  +L  +Q
Sbjct: 1822 SNLE---KLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKR-EAVNSLQEELANVQ 1877

Query: 250  ------------IPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQ 297
                             +++  E +RL + + E  N   + ++E    +         ++
Sbjct: 1878 DHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIE 1937

Query: 298  MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQ 337
              E ++   + + M +R  +ER +S   +LE    +L  Q
Sbjct: 1938 --ENKLKLVQQEMMFQRLQKER-ESEESKLETSKVTLKEQ 1974



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 60/268 (22%), Positives = 108/268 (40%), Gaps = 30/268 (11%)

Query: 87   EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVV--------LLRRSMAEGERARA 138
            +  M Q +++  E  E K    +  L + QH+ EKE+         +L + +A  ER R 
Sbjct: 1946 QEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRT 2005

Query: 139  ASDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQS------ 190
              +    C SL     Q +R L+      Q L +   E    Q+       D S      
Sbjct: 2006 LQEEERWCESLEKTLSQTKRQLSERE---QQLVEKSGELLALQKEADSMRADFSLLRNQF 2062

Query: 191  --EHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGL 248
              E       V S+ E L+ +   L++ +   +  N+  Q+  A+ +   +  H + R L
Sbjct: 2063 LTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRL 2122

Query: 249  QIPHEPELMRKEISRLNRQLEEKINDCAEVKQELA-ASRTARDAALERVQMLEQQILAYK 307
                E   M+ E + L +Q+  +  D    + E++ A RT +    + ++   + +    
Sbjct: 2123 M--KELNQMQYEYTELKKQMANQ-KDLERRQMEISDAMRTLKSEVKDEIRTSLKNL---- 2175

Query: 308  DDFMSE-RADRERAQSRIQELEEKVASL 334
            + F+ E  AD E    R + LE ++ SL
Sbjct: 2176 NQFLPELPADLEAILERNENLEGELESL 2203



 Score = 36.6 bits (83), Expect = 0.045
 Identities = 57/242 (23%), Positives = 100/242 (41%), Gaps = 38/242 (15%)

Query: 80  RQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQH--EREKEVVLLRRSMAEGERAR 137
           RQE  A E    +E+ERL   LE+K  E ++L S+     E  K    L +S+ E    +
Sbjct: 260 RQE--AFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQ 317

Query: 138 AASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHT 197
             S    +S  N  ++L +  T      +    C  + +  Q     +   + E  + + 
Sbjct: 318 KQSCEELKSDLNTKNELLKQKT-----IELTRACQKQYELEQELAFYKIDAKFEPLNYYP 372

Query: 198 SVQSVIEKLQEEN---------RLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGL 248
           S  + I+K  +E+         R +    +++ D     Q      DE +R  H  LRG 
Sbjct: 373 SEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRG- 431

Query: 249 QIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308
              H P         L+ QLE+K       +++++A++T      + ++  EQQIL   +
Sbjct: 432 ---HTP---------LDTQLEDK-------EKKISAAQTRLSELHDEIEKAEQQILRATE 472

Query: 309 DF 310
           +F
Sbjct: 473 EF 474


>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
          Length = 1001

 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 70/309 (22%), Positives = 131/309 (42%), Gaps = 31/309 (10%)

Query: 83  GGAAEAQMRQEIE-------RLTERLEEKEREMQQLLSQPQ---HEREKEVVLLRRSMAE 132
           GG A+ Q+ +E+         L E L E  RE Q+L  + Q      ++E V    +  +
Sbjct: 606 GGLAKGQLEKEMSVLRLSNSNLLEELGELGRERQRLQRELQSLSQRLQREFVPKPEAQVQ 665

Query: 133 GERARAASDVLCRSLANE---THQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQ 189
            ++ R +  +L   LA E   T +LR+ L + +   + L  CL      +R+   ++ + 
Sbjct: 666 LQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGERSAQSKAAES 725

Query: 190 SEH--------TDGHTSVQSVIEKLQEENRLLKQKVTHVED----LNAKWQRYNASRDEY 237
            E          D H   Q V+ +LQEEN+ L+  ++   +    L A      A+ ++ 
Sbjct: 726 LEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCREPGTSLKAPASPQVAALEQD 785

Query: 238 VRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAAS----RTARDAAL 293
           +  L  +LR +Q     +   +EI +L + L +   + AE++   AAS       R + +
Sbjct: 786 LGKLEEELRAVQATMSGK--SQEIGKLKQLLYQATEEVAELRAREAASLRQHEKTRGSLV 843

Query: 294 ERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIH 353
            + Q   Q++ A  + + +   +  R +  + E   +   L  Q + ++       GR  
Sbjct: 844 AQAQAWGQELKALLEKYNTACREVGRLREAVAEERRRSGDLAAQAAEQERQASEMRGRSE 903

Query: 354 AGSKTAKYL 362
              KTA+ L
Sbjct: 904 QFEKTAELL 912


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 84/343 (24%), Positives = 141/343 (41%), Gaps = 50/343 (14%)

Query: 11   EEAPRAAAALCTLYHEAGQRLR----RLQDQLAARDALIARLRARLAALEGDAAPSLVDA 66
            E+A   AA    L  E  +R R    R+Q  LAA +    + +A L  +E       + A
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER------LKA 2016

Query: 67   LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEE---------KEREMQQLLSQPQH 117
             +E+  R RE  R ++  A + Q+ QE  +   + EE         KE+E+QQ L Q Q 
Sbjct: 2017 KVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074

Query: 118  EREK---EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE 174
              ++   E    RR+  E E AR  ++        E  Q RR +     + Q   +    
Sbjct: 2075 VLDQLRGEAEAARRAAEEAEEARVQAE-------REAAQSRRQVEEAERLKQSAEEQAQA 2127

Query: 175  RQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLN------AKWQ 228
            R  AQ    E+   ++E        Q    + Q E   L+QK     ++        +  
Sbjct: 2128 RAQAQA-AAEKLRKEAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178

Query: 229  RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288
            R  A  ++ +  L  QL   +  H+  L+ +E+ RL  +  E     ++V++EL + R  
Sbjct: 2179 RQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236

Query: 289  RD--AALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEE 329
             +  + L+     E + L  +D   ++R  +E A+   Q  EE
Sbjct: 2237 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 43/360 (11%)

Query: 29   QRLRRLQDQLAARDALIARLRARLAAL---EGDAAPSLVDALLEQVARFREQLRRQEGGA 85
            + L  ++ Q+     L AR+ A   AL   + D     +    E++ +  E+  R    A
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2287

Query: 86   AEA----QMRQEIERLTERLEEK--EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAA 139
             EA    Q+ +E       L EK  + +MQ +    + + E E++  ++ +A+ +  R  
Sbjct: 2288 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2347

Query: 140  SDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG-- 195
             D   + + LA ET   +RTL A     Q   +   E +  +  V E S  Q+   +   
Sbjct: 2348 EDKEQMAQQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2404

Query: 196  --HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
                  + + EKL       ++KVT V+ L  + Q                    Q  H+
Sbjct: 2405 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------------QSDHD 2444

Query: 254  PELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR-DAALERVQMLEQQILAYKDDFMS 312
             E +R+ I+ L R+ E+   +   ++ +    +T + +  L+  Q L+Q  L+ KD  + 
Sbjct: 2445 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504

Query: 313  ERADRERAQSRIQELEE----KVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368
                 E+ ++++++L +    K   L  +   +Q   E +  R+ A  + A+    +A E
Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2564



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 86/341 (25%), Positives = 138/341 (40%), Gaps = 26/341 (7%)

Query: 26   EAGQRLRR-LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84
            E  +RLRR +QD+   +      L +R+ A E +AA     AL     +  E+LR Q   
Sbjct: 1494 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRAL-----QALEELRLQ--- 1544

Query: 85   AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG----ERARAAS 140
            A EA+      RL +   E+ R++Q  L   Q   E E+   R S AE     ER+    
Sbjct: 1545 AEEAE-----RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1599

Query: 141  DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV- 199
             V    L  E  + R    A A   +  A+   ER   + N   R   Q+E      S+ 
Sbjct: 1600 HVAVAQLREEAER-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658

Query: 200  QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259
            Q+  EK +EE     ++    E+   + +       E  R L       ++  E EL+R 
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR- 1717

Query: 260  EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRER 319
                L  + E+       +++ELA  +    AA ++ Q LE ++   + +     A + R
Sbjct: 1718 ----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1773

Query: 320  AQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360
            A+   +   EK    L   + R      +A R+ A ++ AK
Sbjct: 1774 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 32/300 (10%)

Query: 27   AGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAA 86
            A ++LR+  +Q AAR     R +A  AAL    A    DA +E+  +F EQ  RQ+    
Sbjct: 2134 AAEKLRKEAEQEAAR-----RAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---- 2181

Query: 87   EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRS 146
             AQ+ QE+  L  +LEE + +   L        ++E+  L+    E  R R+  +    S
Sbjct: 2182 -AQVEQELTTLRLQLEETDHQKNLL--------DEELQRLKAEATEAARQRSQVEEELFS 2232

Query: 147  LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKL 206
            +  +  +L +         ++ A  L ++ + QR + E +    +  +    +    ++ 
Sbjct: 2233 VRVQMEELSKLKARIE--AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2290

Query: 207  QEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNR 266
                +L ++ +     L  K  +      +    L A+   LQ   + EL +++  RL  
Sbjct: 2291 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ--QQKELAQEQARRLQE 2348

Query: 267  QLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326
              E+       + Q+LA         LE  +  + ++ A  +      A+  RAQ+R +E
Sbjct: 2349 DKEQ-------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2401



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 84/403 (20%), Positives = 165/403 (40%), Gaps = 32/403 (7%)

Query: 26   EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85
            EA +R +  +  +  R+     L  +    EG A   L  A  +++ R R +   ++G  
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAET--EQGEQ 1727

Query: 86   AEAQMRQEIERLTERLEEKEREMQQLLSQPQHER-EKEVVLLRRSMAEGERARAASDVLC 144
                + +E+ RL        ++ Q+L ++    R E EV+L  ++ AE E +R+ S+   
Sbjct: 1728 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE-EESRSTSEKSK 1786

Query: 145  RSLANETHQLR---------RTLTATAHMCQHLAK--CLDERQHAQRNVGERSPDQSEHT 193
            + L  E  + R         R L   A   + LA+     +R  A+R + E+     E T
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846

Query: 194  DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
               T  +  +++ + EN  L++     ED   + +R      ++   +  +L  L+   +
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903

Query: 254  PELMR-----KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308
             EL R     ++  R  RQ+EE+I       ++ AA +   +  L R++   +  L  K+
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963

Query: 309  DFMSE-------RADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKY 361
                E        A+ ER +   +E  +K  +   + + ++ +   +  R+ A  + A+ 
Sbjct: 1964 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2023

Query: 362  LAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQ 404
            L   A +            +Q+     E  H  A Q+ + +LQ
Sbjct: 2024 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2066



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 75/329 (22%), Positives = 133/329 (40%), Gaps = 51/329 (15%)

Query: 26   EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ---- 81
            EA QR RRL++Q A   A I    A+L     D+       L+E   R R Q+  +    
Sbjct: 1873 EAFQR-RRLEEQAAQHKADIEERLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILAL 1930

Query: 82   -----EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERA 136
                 +  A +A++  E+ R+    E+  R  +Q         E E    R+  AE ER 
Sbjct: 1931 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA--------ELEAARQRQLAAEEERR 1982

Query: 137  RA-ASDVLCRSLANETHQLRRT---------LTATAHMCQHLAKCLDERQHAQRNVGERS 186
            R  A + + +SLA E    R+          L A     + L +  ++    Q  + + +
Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2042

Query: 187  PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246
              +    +      +V +K QE  + L+Q+ + ++ L  + +    + +E      A+  
Sbjct: 2043 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEA 2096

Query: 247  GLQIPHEPELMRKEIS---RLNRQLEEKINDCA-----------EVKQELAASRTARDAA 292
             +Q   E    R+++    RL +  EE+    A           E +QE A    A  AA
Sbjct: 2097 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2156

Query: 293  LERVQMLEQQILAYKDDFMSERADRERAQ 321
            L + Q  + ++  +K    +E+  R++AQ
Sbjct: 2157 LRQKQAADAEMEKHKK--FAEQTLRQKAQ 2183



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 89/393 (22%), Positives = 165/393 (41%), Gaps = 72/393 (18%)

Query: 33   RLQDQLAARDALIARLRARLAAL---------EGDAAPSLVDALLEQVARFREQL----- 78
            RLQ +   RD  + R R R+A L         + D     ++ L  Q+  +RE       
Sbjct: 1162 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1221

Query: 79   ------RRQE---------GGAAEAQMRQE------IERLTERLEEKEREMQQLLSQPQH 117
                  RRQE           A   Q+RQE      IER  E++EE +R  +Q ++  + 
Sbjct: 1222 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK- 1280

Query: 118  EREKEVVLLR------RSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKC 171
            + E ++V  +       S A+  + ++ S+ + +   +         T T+   + +++ 
Sbjct: 1281 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1340

Query: 172  LDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK---LQEENRLLK-QKVTHVEDLNAKW 227
            L   +  +R   ++  ++ E       V++ +EK   L E +   K Q     ++L  + 
Sbjct: 1341 LRRMEEEERLAEQQRAEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1397

Query: 228  QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287
            Q     R+E       Q R +Q         +E+ +L +  E +I   A+ +Q  AA R+
Sbjct: 1398 QEEVVRREEAAVDAQQQKRSIQ---------EELQQLRQSSEAEIQ--AKARQAEAAERS 1446

Query: 288  ----ARDAALERVQM--LEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV--- 338
                  +  + R+Q+   E+Q    + +  + RA  E A+++ ++ +E+   L  QV   
Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506

Query: 339  SWRQDSREPD-AGRIHAGSKTA--KYLAADALE 368
            S R+   E + A R+ A ++ A  K  A  ALE
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALE 1539



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 46/353 (13%)

Query: 11   EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIAR--LRARLAAL-EGDAAPSLVDAL 67
            EEA R + A      +   RLR+L ++  A+   +A   L+ ++ A+ E     +  + L
Sbjct: 2278 EEAARLSVAA-----QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2332

Query: 68   LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124
             +Q    +EQ RR         ++++ E++ ++L E+ +  Q+ L    Q Q E   E  
Sbjct: 2333 QQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2383

Query: 125  LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184
             L+  +AE  RA+A ++   +    +  ++   L  T    Q     L +    QR   +
Sbjct: 2384 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSD 2442

Query: 185  RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW--QRYNASRDEYVRGLH 242
               D     +    ++   EKLQ+E +LL+ K   ++ +  +   Q   A +  ++    
Sbjct: 2443 H--DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2500

Query: 243  AQLRGLQIPHEP-----ELMRKEISRLNRQLEEKINDCAEVKQE----LAASRTAR---- 289
            + L+  +   +      +L + E+++  +  EE+     +++QE    +A+   AR    
Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2560

Query: 290  ------DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
                      E +Q LEQQ    +++ ++E   R R Q ++ E E+  A+L H
Sbjct: 2561 EAEEGVRRKQEELQQLEQQ-RRQQEELLAEENQRLREQLQLLE-EQHRAALAH 2611



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 98/393 (24%), Positives = 156/393 (39%), Gaps = 42/393 (10%)

Query: 62   SLVDALLEQVARF-REQLRR--QEGGAAEAQMRQEIERLTE--RLEEKEREMQQLLSQPQ 116
            S +  L  Q  +F  E LRR  +E   AE Q  +E ERL E     EK+R++ +  +Q +
Sbjct: 1324 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1383

Query: 117  HEREKEVVLLRRSMAEG----ERARAASDVLCRSLANETHQLRRTLTA-------TAHMC 165
             + E+E   L++ M E     E A   +    RS+  E  QLR++  A        A   
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1443

Query: 166  QHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225
            +     ++E     R   E +  Q    +G   +Q++  + +E     +Q     E L  
Sbjct: 1444 ERSRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRR 1501

Query: 226  KWQRYNASRDEYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAA 284
            + Q      DE  R   A++    ++  E E  R E  R  + LEE      E ++ L  
Sbjct: 1502 QVQ------DESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1554

Query: 285  SRTAR----DAALERVQ-MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339
            +   R      ALE  Q   E ++ + +  F  + A  ER+   +QE    VA L  +  
Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAE 1611

Query: 340  WR-QDSREPDAGRIHAGSKTAKY--LAADALELMVPG---GWRPGTGSQQPEPPAEGGHP 393
             R Q   E +  R  A  +  ++   A +AL L +       +      + E   E    
Sbjct: 1612 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671

Query: 394  GAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAE 426
             A +RG+ + Q     Q    EQ  E  R +AE
Sbjct: 1672 EARRRGKAEEQAVR--QRELAEQELEKQRQLAE 1702


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 84/343 (24%), Positives = 141/343 (41%), Gaps = 50/343 (14%)

Query: 11   EEAPRAAAALCTLYHEAGQRLR----RLQDQLAARDALIARLRARLAALEGDAAPSLVDA 66
            E+A   AA    L  E  +R R    R+Q  LAA +    + +A L  +E       + A
Sbjct: 1967 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER------LKA 2020

Query: 67   LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEE---------KEREMQQLLSQPQH 117
             +E+  R RE  R ++  A + Q+ QE  +   + EE         KE+E+QQ L Q Q 
Sbjct: 2021 KVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2078

Query: 118  EREK---EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE 174
              ++   E    RR+  E E AR  ++        E  Q RR +     + Q   +    
Sbjct: 2079 VLDQLRGEAEAARRAAEEAEEARVQAE-------REAAQSRRQVEEAERLKQSAEEQAQA 2131

Query: 175  RQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLN------AKWQ 228
            R  AQ    E+   ++E        Q    + Q E   L+QK     ++        +  
Sbjct: 2132 RAQAQA-AAEKLRKEAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2182

Query: 229  RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288
            R  A  ++ +  L  QL   +  H+  L+ +E+ RL  +  E     ++V++EL + R  
Sbjct: 2183 RQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2240

Query: 289  RD--AALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEE 329
             +  + L+     E + L  +D   ++R  +E A+   Q  EE
Sbjct: 2241 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2283



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 43/360 (11%)

Query: 29   QRLRRLQDQLAARDALIARLRARLAAL---EGDAAPSLVDALLEQVARFREQLRRQEGGA 85
            + L  ++ Q+     L AR+ A   AL   + D     +    E++ +  E+  R    A
Sbjct: 2232 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2291

Query: 86   AEA----QMRQEIERLTERLEEK--EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAA 139
             EA    Q+ +E       L EK  + +MQ +    + + E E++  ++ +A+ +  R  
Sbjct: 2292 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2351

Query: 140  SDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG-- 195
             D   + + LA ET   +RTL A     Q   +   E +  +  V E S  Q+   +   
Sbjct: 2352 EDKEQMAQQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2408

Query: 196  --HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
                  + + EKL       ++KVT V+ L  + Q                    Q  H+
Sbjct: 2409 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------------QSDHD 2448

Query: 254  PELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR-DAALERVQMLEQQILAYKDDFMS 312
             E +R+ I+ L R+ E+   +   ++ +    +T + +  L+  Q L+Q  L+ KD  + 
Sbjct: 2449 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2508

Query: 313  ERADRERAQSRIQELEE----KVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368
                 E+ ++++++L +    K   L  +   +Q   E +  R+ A  + A+    +A E
Sbjct: 2509 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2568



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 86/341 (25%), Positives = 138/341 (40%), Gaps = 26/341 (7%)

Query: 26   EAGQRLRR-LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84
            E  +RLRR +QD+   +      L +R+ A E +AA     AL     +  E+LR Q   
Sbjct: 1498 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRAL-----QALEELRLQ--- 1548

Query: 85   AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG----ERARAAS 140
            A EA+      RL +   E+ R++Q  L   Q   E E+   R S AE     ER+    
Sbjct: 1549 AEEAE-----RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1603

Query: 141  DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV- 199
             V    L  E  + R    A A   +  A+   ER   + N   R   Q+E      S+ 
Sbjct: 1604 HVAVAQLREEAER-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1662

Query: 200  QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259
            Q+  EK +EE     ++    E+   + +       E  R L       ++  E EL+R 
Sbjct: 1663 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR- 1721

Query: 260  EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRER 319
                L  + E+       +++ELA  +    AA ++ Q LE ++   + +     A + R
Sbjct: 1722 ----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1777

Query: 320  AQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360
            A+   +   EK    L   + R      +A R+ A ++ AK
Sbjct: 1778 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1818



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 32/300 (10%)

Query: 27   AGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAA 86
            A ++LR+  +Q AAR     R +A  AAL    A    DA +E+  +F EQ  RQ+    
Sbjct: 2138 AAEKLRKEAEQEAAR-----RAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---- 2185

Query: 87   EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRS 146
             AQ+ QE+  L  +LEE + +   L        ++E+  L+    E  R R+  +    S
Sbjct: 2186 -AQVEQELTTLRLQLEETDHQKNLL--------DEELQRLKAEATEAARQRSQVEEELFS 2236

Query: 147  LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKL 206
            +  +  +L +         ++ A  L ++ + QR + E +    +  +    +    ++ 
Sbjct: 2237 VRVQMEELSKLKARIE--AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2294

Query: 207  QEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNR 266
                +L ++ +     L  K  +      +    L A+   LQ   + EL +++  RL  
Sbjct: 2295 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ--QQKELAQEQARRLQE 2352

Query: 267  QLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326
              E+       + Q+LA         LE  +  + ++ A  +      A+  RAQ+R +E
Sbjct: 2353 DKEQ-------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2405



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 84/403 (20%), Positives = 165/403 (40%), Gaps = 32/403 (7%)

Query: 26   EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85
            EA +R +  +  +  R+     L  +    EG A   L  A  +++ R R +   ++G  
Sbjct: 1676 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAET--EQGEQ 1731

Query: 86   AEAQMRQEIERLTERLEEKEREMQQLLSQPQHER-EKEVVLLRRSMAEGERARAASDVLC 144
                + +E+ RL        ++ Q+L ++    R E EV+L  ++ AE E +R+ S+   
Sbjct: 1732 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE-EESRSTSEKSK 1790

Query: 145  RSLANETHQLR---------RTLTATAHMCQHLAK--CLDERQHAQRNVGERSPDQSEHT 193
            + L  E  + R         R L   A   + LA+     +R  A+R + E+     E T
Sbjct: 1791 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1850

Query: 194  DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
               T  +  +++ + EN  L++     ED   + +R      ++   +  +L  L+   +
Sbjct: 1851 RLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1907

Query: 254  PELMR-----KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308
             EL R     ++  R  RQ+EE+I       ++ AA +   +  L R++   +  L  K+
Sbjct: 1908 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1967

Query: 309  DFMSE-------RADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKY 361
                E        A+ ER +   +E  +K  +   + + ++ +   +  R+ A  + A+ 
Sbjct: 1968 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2027

Query: 362  LAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQ 404
            L   A +            +Q+     E  H  A Q+ + +LQ
Sbjct: 2028 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2070



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 75/329 (22%), Positives = 133/329 (40%), Gaps = 51/329 (15%)

Query: 26   EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ---- 81
            EA QR RRL++Q A   A I    A+L     D+       L+E   R R Q+  +    
Sbjct: 1877 EAFQR-RRLEEQAAQHKADIEERLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILAL 1934

Query: 82   -----EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERA 136
                 +  A +A++  E+ R+    E+  R  +Q         E E    R+  AE ER 
Sbjct: 1935 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA--------ELEAARQRQLAAEEERR 1986

Query: 137  RA-ASDVLCRSLANETHQLRRT---------LTATAHMCQHLAKCLDERQHAQRNVGERS 186
            R  A + + +SLA E    R+          L A     + L +  ++    Q  + + +
Sbjct: 1987 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2046

Query: 187  PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246
              +    +      +V +K QE  + L+Q+ + ++ L  + +    + +E      A+  
Sbjct: 2047 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEA 2100

Query: 247  GLQIPHEPELMRKEIS---RLNRQLEEKINDCA-----------EVKQELAASRTARDAA 292
             +Q   E    R+++    RL +  EE+    A           E +QE A    A  AA
Sbjct: 2101 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2160

Query: 293  LERVQMLEQQILAYKDDFMSERADRERAQ 321
            L + Q  + ++  +K    +E+  R++AQ
Sbjct: 2161 LRQKQAADAEMEKHKK--FAEQTLRQKAQ 2187



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 89/393 (22%), Positives = 165/393 (41%), Gaps = 72/393 (18%)

Query: 33   RLQDQLAARDALIARLRARLAAL---------EGDAAPSLVDALLEQVARFREQL----- 78
            RLQ +   RD  + R R R+A L         + D     ++ L  Q+  +RE       
Sbjct: 1166 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1225

Query: 79   ------RRQE---------GGAAEAQMRQE------IERLTERLEEKEREMQQLLSQPQH 117
                  RRQE           A   Q+RQE      IER  E++EE +R  +Q ++  + 
Sbjct: 1226 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK- 1284

Query: 118  EREKEVVLLR------RSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKC 171
            + E ++V  +       S A+  + ++ S+ + +   +         T T+   + +++ 
Sbjct: 1285 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1344

Query: 172  LDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK---LQEENRLLK-QKVTHVEDLNAKW 227
            L   +  +R   ++  ++ E       V++ +EK   L E +   K Q     ++L  + 
Sbjct: 1345 LRRMEEEERLAEQQRAEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1401

Query: 228  QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287
            Q     R+E       Q R +Q         +E+ +L +  E +I   A+ +Q  AA R+
Sbjct: 1402 QEEVVRREEAAVDAQQQKRSIQ---------EELQQLRQSSEAEIQ--AKARQAEAAERS 1450

Query: 288  ----ARDAALERVQM--LEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV--- 338
                  +  + R+Q+   E+Q    + +  + RA  E A+++ ++ +E+   L  QV   
Sbjct: 1451 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1510

Query: 339  SWRQDSREPD-AGRIHAGSKTA--KYLAADALE 368
            S R+   E + A R+ A ++ A  K  A  ALE
Sbjct: 1511 SQRKRQAEVELASRVKAEAEAAREKQRALQALE 1543



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 46/353 (13%)

Query: 11   EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIAR--LRARLAAL-EGDAAPSLVDAL 67
            EEA R + A      +   RLR+L ++  A+   +A   L+ ++ A+ E     +  + L
Sbjct: 2282 EEAARLSVAA-----QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2336

Query: 68   LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124
             +Q    +EQ RR         ++++ E++ ++L E+ +  Q+ L    Q Q E   E  
Sbjct: 2337 QQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2387

Query: 125  LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184
             L+  +AE  RA+A ++   +    +  ++   L  T    Q     L +    QR   +
Sbjct: 2388 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSD 2446

Query: 185  RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW--QRYNASRDEYVRGLH 242
               D     +    ++   EKLQ+E +LL+ K   ++ +  +   Q   A +  ++    
Sbjct: 2447 H--DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2504

Query: 243  AQLRGLQIPHEP-----ELMRKEISRLNRQLEEKINDCAEVKQE----LAASRTAR---- 289
            + L+  +   +      +L + E+++  +  EE+     +++QE    +A+   AR    
Sbjct: 2505 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2564

Query: 290  ------DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
                      E +Q LEQQ    +++ ++E   R R Q ++ E E+  A+L H
Sbjct: 2565 EAEEGVRRKQEELQQLEQQ-RRQQEELLAEENQRLREQLQLLE-EQHRAALAH 2615



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 98/393 (24%), Positives = 156/393 (39%), Gaps = 42/393 (10%)

Query: 62   SLVDALLEQVARF-REQLRR--QEGGAAEAQMRQEIERLTE--RLEEKEREMQQLLSQPQ 116
            S +  L  Q  +F  E LRR  +E   AE Q  +E ERL E     EK+R++ +  +Q +
Sbjct: 1328 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1387

Query: 117  HEREKEVVLLRRSMAEG----ERARAASDVLCRSLANETHQLRRTLTA-------TAHMC 165
             + E+E   L++ M E     E A   +    RS+  E  QLR++  A        A   
Sbjct: 1388 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1447

Query: 166  QHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225
            +     ++E     R   E +  Q    +G   +Q++  + +E     +Q     E L  
Sbjct: 1448 ERSRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRR 1505

Query: 226  KWQRYNASRDEYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAA 284
            + Q      DE  R   A++    ++  E E  R E  R  + LEE      E ++ L  
Sbjct: 1506 QVQ------DESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1558

Query: 285  SRTAR----DAALERVQ-MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339
            +   R      ALE  Q   E ++ + +  F  + A  ER+   +QE    VA L  +  
Sbjct: 1559 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAE 1615

Query: 340  WR-QDSREPDAGRIHAGSKTAKY--LAADALELMVPG---GWRPGTGSQQPEPPAEGGHP 393
             R Q   E +  R  A  +  ++   A +AL L +       +      + E   E    
Sbjct: 1616 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1675

Query: 394  GAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAE 426
             A +RG+ + Q     Q    EQ  E  R +AE
Sbjct: 1676 EARRRGKAEEQAVR--QRELAEQELEKQRQLAE 1706


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 84/343 (24%), Positives = 141/343 (41%), Gaps = 50/343 (14%)

Query: 11   EEAPRAAAALCTLYHEAGQRLR----RLQDQLAARDALIARLRARLAALEGDAAPSLVDA 66
            E+A   AA    L  E  +R R    R+Q  LAA +    + +A L  +E       + A
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER------LKA 2016

Query: 67   LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEE---------KEREMQQLLSQPQH 117
             +E+  R RE  R ++  A + Q+ QE  +   + EE         KE+E+QQ L Q Q 
Sbjct: 2017 KVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074

Query: 118  EREK---EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE 174
              ++   E    RR+  E E AR  ++        E  Q RR +     + Q   +    
Sbjct: 2075 VLDQLRGEAEAARRAAEEAEEARVQAE-------REAAQSRRQVEEAERLKQSAEEQAQA 2127

Query: 175  RQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLN------AKWQ 228
            R  AQ    E+   ++E        Q    + Q E   L+QK     ++        +  
Sbjct: 2128 RAQAQA-AAEKLRKEAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178

Query: 229  RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288
            R  A  ++ +  L  QL   +  H+  L+ +E+ RL  +  E     ++V++EL + R  
Sbjct: 2179 RQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236

Query: 289  RD--AALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEE 329
             +  + L+     E + L  +D   ++R  +E A+   Q  EE
Sbjct: 2237 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 43/360 (11%)

Query: 29   QRLRRLQDQLAARDALIARLRARLAAL---EGDAAPSLVDALLEQVARFREQLRRQEGGA 85
            + L  ++ Q+     L AR+ A   AL   + D     +    E++ +  E+  R    A
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2287

Query: 86   AEA----QMRQEIERLTERLEEK--EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAA 139
             EA    Q+ +E       L EK  + +MQ +    + + E E++  ++ +A+ +  R  
Sbjct: 2288 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2347

Query: 140  SDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG-- 195
             D   + + LA ET   +RTL A     Q   +   E +  +  V E S  Q+   +   
Sbjct: 2348 EDKEQMAQQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2404

Query: 196  --HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
                  + + EKL       ++KVT V+ L  + Q                    Q  H+
Sbjct: 2405 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------------QSDHD 2444

Query: 254  PELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR-DAALERVQMLEQQILAYKDDFMS 312
             E +R+ I+ L R+ E+   +   ++ +    +T + +  L+  Q L+Q  L+ KD  + 
Sbjct: 2445 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504

Query: 313  ERADRERAQSRIQELEE----KVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368
                 E+ ++++++L +    K   L  +   +Q   E +  R+ A  + A+    +A E
Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2564



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 86/341 (25%), Positives = 138/341 (40%), Gaps = 26/341 (7%)

Query: 26   EAGQRLRR-LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84
            E  +RLRR +QD+   +      L +R+ A E +AA     AL     +  E+LR Q   
Sbjct: 1494 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRAL-----QALEELRLQ--- 1544

Query: 85   AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG----ERARAAS 140
            A EA+      RL +   E+ R++Q  L   Q   E E+   R S AE     ER+    
Sbjct: 1545 AEEAE-----RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1599

Query: 141  DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV- 199
             V    L  E  + R    A A   +  A+   ER   + N   R   Q+E      S+ 
Sbjct: 1600 HVAVAQLREEAER-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658

Query: 200  QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259
            Q+  EK +EE     ++    E+   + +       E  R L       ++  E EL+R 
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR- 1717

Query: 260  EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRER 319
                L  + E+       +++ELA  +    AA ++ Q LE ++   + +     A + R
Sbjct: 1718 ----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1773

Query: 320  AQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360
            A+   +   EK    L   + R      +A R+ A ++ AK
Sbjct: 1774 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 32/300 (10%)

Query: 27   AGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAA 86
            A ++LR+  +Q AAR     R +A  AAL    A    DA +E+  +F EQ  RQ+    
Sbjct: 2134 AAEKLRKEAEQEAAR-----RAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---- 2181

Query: 87   EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRS 146
             AQ+ QE+  L  +LEE + +   L        ++E+  L+    E  R R+  +    S
Sbjct: 2182 -AQVEQELTTLRLQLEETDHQKNLL--------DEELQRLKAEATEAARQRSQVEEELFS 2232

Query: 147  LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKL 206
            +  +  +L +         ++ A  L ++ + QR + E +    +  +    +    ++ 
Sbjct: 2233 VRVQMEELSKLKARIE--AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2290

Query: 207  QEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNR 266
                +L ++ +     L  K  +      +    L A+   LQ   + EL +++  RL  
Sbjct: 2291 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ--QQKELAQEQARRLQE 2348

Query: 267  QLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326
              E+       + Q+LA         LE  +  + ++ A  +      A+  RAQ+R +E
Sbjct: 2349 DKEQ-------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2401



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 84/403 (20%), Positives = 165/403 (40%), Gaps = 32/403 (7%)

Query: 26   EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85
            EA +R +  +  +  R+     L  +    EG A   L  A  +++ R R +   ++G  
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAET--EQGEQ 1727

Query: 86   AEAQMRQEIERLTERLEEKEREMQQLLSQPQHER-EKEVVLLRRSMAEGERARAASDVLC 144
                + +E+ RL        ++ Q+L ++    R E EV+L  ++ AE E +R+ S+   
Sbjct: 1728 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE-EESRSTSEKSK 1786

Query: 145  RSLANETHQLR---------RTLTATAHMCQHLAK--CLDERQHAQRNVGERSPDQSEHT 193
            + L  E  + R         R L   A   + LA+     +R  A+R + E+     E T
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846

Query: 194  DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
               T  +  +++ + EN  L++     ED   + +R      ++   +  +L  L+   +
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903

Query: 254  PELMR-----KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308
             EL R     ++  R  RQ+EE+I       ++ AA +   +  L R++   +  L  K+
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963

Query: 309  DFMSE-------RADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKY 361
                E        A+ ER +   +E  +K  +   + + ++ +   +  R+ A  + A+ 
Sbjct: 1964 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2023

Query: 362  LAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQ 404
            L   A +            +Q+     E  H  A Q+ + +LQ
Sbjct: 2024 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2066



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 75/329 (22%), Positives = 133/329 (40%), Gaps = 51/329 (15%)

Query: 26   EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ---- 81
            EA QR RRL++Q A   A I    A+L     D+       L+E   R R Q+  +    
Sbjct: 1873 EAFQR-RRLEEQAAQHKADIEERLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILAL 1930

Query: 82   -----EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERA 136
                 +  A +A++  E+ R+    E+  R  +Q         E E    R+  AE ER 
Sbjct: 1931 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA--------ELEAARQRQLAAEEERR 1982

Query: 137  RA-ASDVLCRSLANETHQLRRT---------LTATAHMCQHLAKCLDERQHAQRNVGERS 186
            R  A + + +SLA E    R+          L A     + L +  ++    Q  + + +
Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2042

Query: 187  PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246
              +    +      +V +K QE  + L+Q+ + ++ L  + +    + +E      A+  
Sbjct: 2043 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEA 2096

Query: 247  GLQIPHEPELMRKEIS---RLNRQLEEKINDCA-----------EVKQELAASRTARDAA 292
             +Q   E    R+++    RL +  EE+    A           E +QE A    A  AA
Sbjct: 2097 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2156

Query: 293  LERVQMLEQQILAYKDDFMSERADRERAQ 321
            L + Q  + ++  +K    +E+  R++AQ
Sbjct: 2157 LRQKQAADAEMEKHKK--FAEQTLRQKAQ 2183



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 89/393 (22%), Positives = 165/393 (41%), Gaps = 72/393 (18%)

Query: 33   RLQDQLAARDALIARLRARLAAL---------EGDAAPSLVDALLEQVARFREQL----- 78
            RLQ +   RD  + R R R+A L         + D     ++ L  Q+  +RE       
Sbjct: 1162 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1221

Query: 79   ------RRQE---------GGAAEAQMRQE------IERLTERLEEKEREMQQLLSQPQH 117
                  RRQE           A   Q+RQE      IER  E++EE +R  +Q ++  + 
Sbjct: 1222 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK- 1280

Query: 118  EREKEVVLLR------RSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKC 171
            + E ++V  +       S A+  + ++ S+ + +   +         T T+   + +++ 
Sbjct: 1281 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1340

Query: 172  LDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK---LQEENRLLK-QKVTHVEDLNAKW 227
            L   +  +R   ++  ++ E       V++ +EK   L E +   K Q     ++L  + 
Sbjct: 1341 LRRMEEEERLAEQQRAEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1397

Query: 228  QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287
            Q     R+E       Q R +Q         +E+ +L +  E +I   A+ +Q  AA R+
Sbjct: 1398 QEEVVRREEAAVDAQQQKRSIQ---------EELQQLRQSSEAEIQ--AKARQAEAAERS 1446

Query: 288  ----ARDAALERVQM--LEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV--- 338
                  +  + R+Q+   E+Q    + +  + RA  E A+++ ++ +E+   L  QV   
Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506

Query: 339  SWRQDSREPD-AGRIHAGSKTA--KYLAADALE 368
            S R+   E + A R+ A ++ A  K  A  ALE
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALE 1539



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 46/353 (13%)

Query: 11   EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIAR--LRARLAAL-EGDAAPSLVDAL 67
            EEA R + A      +   RLR+L ++  A+   +A   L+ ++ A+ E     +  + L
Sbjct: 2278 EEAARLSVAA-----QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2332

Query: 68   LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124
             +Q    +EQ RR         ++++ E++ ++L E+ +  Q+ L    Q Q E   E  
Sbjct: 2333 QQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2383

Query: 125  LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184
             L+  +AE  RA+A ++   +    +  ++   L  T    Q     L +    QR   +
Sbjct: 2384 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSD 2442

Query: 185  RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW--QRYNASRDEYVRGLH 242
               D     +    ++   EKLQ+E +LL+ K   ++ +  +   Q   A +  ++    
Sbjct: 2443 H--DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2500

Query: 243  AQLRGLQIPHEP-----ELMRKEISRLNRQLEEKINDCAEVKQE----LAASRTAR---- 289
            + L+  +   +      +L + E+++  +  EE+     +++QE    +A+   AR    
Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2560

Query: 290  ------DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
                      E +Q LEQQ    +++ ++E   R R Q ++ E E+  A+L H
Sbjct: 2561 EAEEGVRRKQEELQQLEQQ-RRQQEELLAEENQRLREQLQLLE-EQHRAALAH 2611



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 98/393 (24%), Positives = 156/393 (39%), Gaps = 42/393 (10%)

Query: 62   SLVDALLEQVARF-REQLRR--QEGGAAEAQMRQEIERLTE--RLEEKEREMQQLLSQPQ 116
            S +  L  Q  +F  E LRR  +E   AE Q  +E ERL E     EK+R++ +  +Q +
Sbjct: 1324 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1383

Query: 117  HEREKEVVLLRRSMAEG----ERARAASDVLCRSLANETHQLRRTLTA-------TAHMC 165
             + E+E   L++ M E     E A   +    RS+  E  QLR++  A        A   
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1443

Query: 166  QHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225
            +     ++E     R   E +  Q    +G   +Q++  + +E     +Q     E L  
Sbjct: 1444 ERSRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRR 1501

Query: 226  KWQRYNASRDEYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAA 284
            + Q      DE  R   A++    ++  E E  R E  R  + LEE      E ++ L  
Sbjct: 1502 QVQ------DESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1554

Query: 285  SRTAR----DAALERVQ-MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339
            +   R      ALE  Q   E ++ + +  F  + A  ER+   +QE    VA L  +  
Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAE 1611

Query: 340  WR-QDSREPDAGRIHAGSKTAKY--LAADALELMVPG---GWRPGTGSQQPEPPAEGGHP 393
             R Q   E +  R  A  +  ++   A +AL L +       +      + E   E    
Sbjct: 1612 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671

Query: 394  GAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAE 426
             A +RG+ + Q     Q    EQ  E  R +AE
Sbjct: 1672 EARRRGKAEEQAVR--QRELAEQELEKQRQLAE 1702


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 84/343 (24%), Positives = 141/343 (41%), Gaps = 50/343 (14%)

Query: 11   EEAPRAAAALCTLYHEAGQRLR----RLQDQLAARDALIARLRARLAALEGDAAPSLVDA 66
            E+A   AA    L  E  +R R    R+Q  LAA +    + +A L  +E       + A
Sbjct: 1931 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER------LKA 1984

Query: 67   LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEE---------KEREMQQLLSQPQH 117
             +E+  R RE  R ++  A + Q+ QE  +   + EE         KE+E+QQ L Q Q 
Sbjct: 1985 KVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2042

Query: 118  EREK---EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE 174
              ++   E    RR+  E E AR  ++        E  Q RR +     + Q   +    
Sbjct: 2043 VLDQLRGEAEAARRAAEEAEEARVQAE-------REAAQSRRQVEEAERLKQSAEEQAQA 2095

Query: 175  RQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLN------AKWQ 228
            R  AQ    E+   ++E        Q    + Q E   L+QK     ++        +  
Sbjct: 2096 RAQAQA-AAEKLRKEAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2146

Query: 229  RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288
            R  A  ++ +  L  QL   +  H+  L+ +E+ RL  +  E     ++V++EL + R  
Sbjct: 2147 RQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2204

Query: 289  RD--AALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEE 329
             +  + L+     E + L  +D   ++R  +E A+   Q  EE
Sbjct: 2205 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2247



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 43/360 (11%)

Query: 29   QRLRRLQDQLAARDALIARLRARLAAL---EGDAAPSLVDALLEQVARFREQLRRQEGGA 85
            + L  ++ Q+     L AR+ A   AL   + D     +    E++ +  E+  R    A
Sbjct: 2196 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2255

Query: 86   AEA----QMRQEIERLTERLEEK--EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAA 139
             EA    Q+ +E       L EK  + +MQ +    + + E E++  ++ +A+ +  R  
Sbjct: 2256 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2315

Query: 140  SDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG-- 195
             D   + + LA ET   +RTL A     Q   +   E +  +  V E S  Q+   +   
Sbjct: 2316 EDKEQMAQQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2372

Query: 196  --HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
                  + + EKL       ++KVT V+ L  + Q                    Q  H+
Sbjct: 2373 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------------QSDHD 2412

Query: 254  PELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR-DAALERVQMLEQQILAYKDDFMS 312
             E +R+ I+ L R+ E+   +   ++ +    +T + +  L+  Q L+Q  L+ KD  + 
Sbjct: 2413 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2472

Query: 313  ERADRERAQSRIQELEE----KVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368
                 E+ ++++++L +    K   L  +   +Q   E +  R+ A  + A+    +A E
Sbjct: 2473 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2532



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 86/341 (25%), Positives = 138/341 (40%), Gaps = 26/341 (7%)

Query: 26   EAGQRLRR-LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84
            E  +RLRR +QD+   +      L +R+ A E +AA     AL     +  E+LR Q   
Sbjct: 1462 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRAL-----QALEELRLQ--- 1512

Query: 85   AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG----ERARAAS 140
            A EA+      RL +   E+ R++Q  L   Q   E E+   R S AE     ER+    
Sbjct: 1513 AEEAE-----RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1567

Query: 141  DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV- 199
             V    L  E  + R    A A   +  A+   ER   + N   R   Q+E      S+ 
Sbjct: 1568 HVAVAQLREEAER-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1626

Query: 200  QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259
            Q+  EK +EE     ++    E+   + +       E  R L       ++  E EL+R 
Sbjct: 1627 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR- 1685

Query: 260  EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRER 319
                L  + E+       +++ELA  +    AA ++ Q LE ++   + +     A + R
Sbjct: 1686 ----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1741

Query: 320  AQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360
            A+   +   EK    L   + R      +A R+ A ++ AK
Sbjct: 1742 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1782



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 32/300 (10%)

Query: 27   AGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAA 86
            A ++LR+  +Q AAR     R +A  AAL    A    DA +E+  +F EQ  RQ+    
Sbjct: 2102 AAEKLRKEAEQEAAR-----RAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---- 2149

Query: 87   EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRS 146
             AQ+ QE+  L  +LEE + +   L        ++E+  L+    E  R R+  +    S
Sbjct: 2150 -AQVEQELTTLRLQLEETDHQKNLL--------DEELQRLKAEATEAARQRSQVEEELFS 2200

Query: 147  LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKL 206
            +  +  +L +         ++ A  L ++ + QR + E +    +  +    +    ++ 
Sbjct: 2201 VRVQMEELSKLKARIE--AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2258

Query: 207  QEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNR 266
                +L ++ +     L  K  +      +    L A+   LQ   + EL +++  RL  
Sbjct: 2259 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ--QQKELAQEQARRLQE 2316

Query: 267  QLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326
              E+       + Q+LA         LE  +  + ++ A  +      A+  RAQ+R +E
Sbjct: 2317 DKEQ-------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2369



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 84/403 (20%), Positives = 165/403 (40%), Gaps = 32/403 (7%)

Query: 26   EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85
            EA +R +  +  +  R+     L  +    EG A   L  A  +++ R R +   ++G  
Sbjct: 1640 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAET--EQGEQ 1695

Query: 86   AEAQMRQEIERLTERLEEKEREMQQLLSQPQHER-EKEVVLLRRSMAEGERARAASDVLC 144
                + +E+ RL        ++ Q+L ++    R E EV+L  ++ AE E +R+ S+   
Sbjct: 1696 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE-EESRSTSEKSK 1754

Query: 145  RSLANETHQLR---------RTLTATAHMCQHLAK--CLDERQHAQRNVGERSPDQSEHT 193
            + L  E  + R         R L   A   + LA+     +R  A+R + E+     E T
Sbjct: 1755 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1814

Query: 194  DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
               T  +  +++ + EN  L++     ED   + +R      ++   +  +L  L+   +
Sbjct: 1815 RLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1871

Query: 254  PELMR-----KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308
             EL R     ++  R  RQ+EE+I       ++ AA +   +  L R++   +  L  K+
Sbjct: 1872 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1931

Query: 309  DFMSE-------RADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKY 361
                E        A+ ER +   +E  +K  +   + + ++ +   +  R+ A  + A+ 
Sbjct: 1932 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 1991

Query: 362  LAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQ 404
            L   A +            +Q+     E  H  A Q+ + +LQ
Sbjct: 1992 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2034



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 75/329 (22%), Positives = 133/329 (40%), Gaps = 51/329 (15%)

Query: 26   EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ---- 81
            EA QR RRL++Q A   A I    A+L     D+       L+E   R R Q+  +    
Sbjct: 1841 EAFQR-RRLEEQAAQHKADIEERLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILAL 1898

Query: 82   -----EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERA 136
                 +  A +A++  E+ R+    E+  R  +Q         E E    R+  AE ER 
Sbjct: 1899 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA--------ELEAARQRQLAAEEERR 1950

Query: 137  RA-ASDVLCRSLANETHQLRRT---------LTATAHMCQHLAKCLDERQHAQRNVGERS 186
            R  A + + +SLA E    R+          L A     + L +  ++    Q  + + +
Sbjct: 1951 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2010

Query: 187  PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246
              +    +      +V +K QE  + L+Q+ + ++ L  + +    + +E      A+  
Sbjct: 2011 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEA 2064

Query: 247  GLQIPHEPELMRKEIS---RLNRQLEEKINDCA-----------EVKQELAASRTARDAA 292
             +Q   E    R+++    RL +  EE+    A           E +QE A    A  AA
Sbjct: 2065 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2124

Query: 293  LERVQMLEQQILAYKDDFMSERADRERAQ 321
            L + Q  + ++  +K    +E+  R++AQ
Sbjct: 2125 LRQKQAADAEMEKHKK--FAEQTLRQKAQ 2151



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 89/393 (22%), Positives = 165/393 (41%), Gaps = 72/393 (18%)

Query: 33   RLQDQLAARDALIARLRARLAAL---------EGDAAPSLVDALLEQVARFREQL----- 78
            RLQ +   RD  + R R R+A L         + D     ++ L  Q+  +RE       
Sbjct: 1130 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1189

Query: 79   ------RRQE---------GGAAEAQMRQE------IERLTERLEEKEREMQQLLSQPQH 117
                  RRQE           A   Q+RQE      IER  E++EE +R  +Q ++  + 
Sbjct: 1190 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK- 1248

Query: 118  EREKEVVLLR------RSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKC 171
            + E ++V  +       S A+  + ++ S+ + +   +         T T+   + +++ 
Sbjct: 1249 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1308

Query: 172  LDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK---LQEENRLLK-QKVTHVEDLNAKW 227
            L   +  +R   ++  ++ E       V++ +EK   L E +   K Q     ++L  + 
Sbjct: 1309 LRRMEEEERLAEQQRAEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1365

Query: 228  QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287
            Q     R+E       Q R +Q         +E+ +L +  E +I   A+ +Q  AA R+
Sbjct: 1366 QEEVVRREEAAVDAQQQKRSIQ---------EELQQLRQSSEAEIQ--AKARQAEAAERS 1414

Query: 288  ----ARDAALERVQM--LEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV--- 338
                  +  + R+Q+   E+Q    + +  + RA  E A+++ ++ +E+   L  QV   
Sbjct: 1415 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1474

Query: 339  SWRQDSREPD-AGRIHAGSKTA--KYLAADALE 368
            S R+   E + A R+ A ++ A  K  A  ALE
Sbjct: 1475 SQRKRQAEVELASRVKAEAEAAREKQRALQALE 1507



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 46/353 (13%)

Query: 11   EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIAR--LRARLAAL-EGDAAPSLVDAL 67
            EEA R + A      +   RLR+L ++  A+   +A   L+ ++ A+ E     +  + L
Sbjct: 2246 EEAARLSVAA-----QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2300

Query: 68   LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124
             +Q    +EQ RR         ++++ E++ ++L E+ +  Q+ L    Q Q E   E  
Sbjct: 2301 QQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2351

Query: 125  LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184
             L+  +AE  RA+A ++   +    +  ++   L  T    Q     L +    QR   +
Sbjct: 2352 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSD 2410

Query: 185  RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW--QRYNASRDEYVRGLH 242
               D     +    ++   EKLQ+E +LL+ K   ++ +  +   Q   A +  ++    
Sbjct: 2411 H--DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2468

Query: 243  AQLRGLQIPHEP-----ELMRKEISRLNRQLEEKINDCAEVKQE----LAASRTAR---- 289
            + L+  +   +      +L + E+++  +  EE+     +++QE    +A+   AR    
Sbjct: 2469 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2528

Query: 290  ------DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
                      E +Q LEQQ    +++ ++E   R R Q ++ E E+  A+L H
Sbjct: 2529 EAEEGVRRKQEELQQLEQQ-RRQQEELLAEENQRLREQLQLLE-EQHRAALAH 2579



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 98/393 (24%), Positives = 156/393 (39%), Gaps = 42/393 (10%)

Query: 62   SLVDALLEQVARF-REQLRR--QEGGAAEAQMRQEIERLTE--RLEEKEREMQQLLSQPQ 116
            S +  L  Q  +F  E LRR  +E   AE Q  +E ERL E     EK+R++ +  +Q +
Sbjct: 1292 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1351

Query: 117  HEREKEVVLLRRSMAEG----ERARAASDVLCRSLANETHQLRRTLTA-------TAHMC 165
             + E+E   L++ M E     E A   +    RS+  E  QLR++  A        A   
Sbjct: 1352 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1411

Query: 166  QHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225
            +     ++E     R   E +  Q    +G   +Q++  + +E     +Q     E L  
Sbjct: 1412 ERSRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRR 1469

Query: 226  KWQRYNASRDEYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAA 284
            + Q      DE  R   A++    ++  E E  R E  R  + LEE      E ++ L  
Sbjct: 1470 QVQ------DESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1522

Query: 285  SRTAR----DAALERVQ-MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339
            +   R      ALE  Q   E ++ + +  F  + A  ER+   +QE    VA L  +  
Sbjct: 1523 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAE 1579

Query: 340  WR-QDSREPDAGRIHAGSKTAKY--LAADALELMVPG---GWRPGTGSQQPEPPAEGGHP 393
             R Q   E +  R  A  +  ++   A +AL L +       +      + E   E    
Sbjct: 1580 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1639

Query: 394  GAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAE 426
             A +RG+ + Q     Q    EQ  E  R +AE
Sbjct: 1640 EARRRGKAEEQAVR--QRELAEQELEKQRQLAE 1670


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 84/343 (24%), Positives = 141/343 (41%), Gaps = 50/343 (14%)

Query: 11   EEAPRAAAALCTLYHEAGQRLR----RLQDQLAARDALIARLRARLAALEGDAAPSLVDA 66
            E+A   AA    L  E  +R R    R+Q  LAA +    + +A L  +E       + A
Sbjct: 2100 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER------LKA 2153

Query: 67   LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEE---------KEREMQQLLSQPQH 117
             +E+  R RE  R ++  A + Q+ QE  +   + EE         KE+E+QQ L Q Q 
Sbjct: 2154 KVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2211

Query: 118  EREK---EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE 174
              ++   E    RR+  E E AR  ++        E  Q RR +     + Q   +    
Sbjct: 2212 VLDQLRGEAEAARRAAEEAEEARVQAE-------REAAQSRRQVEEAERLKQSAEEQAQA 2264

Query: 175  RQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLN------AKWQ 228
            R  AQ    E+   ++E        Q    + Q E   L+QK     ++        +  
Sbjct: 2265 RAQAQA-AAEKLRKEAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2315

Query: 229  RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288
            R  A  ++ +  L  QL   +  H+  L+ +E+ RL  +  E     ++V++EL + R  
Sbjct: 2316 RQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2373

Query: 289  RD--AALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEE 329
             +  + L+     E + L  +D   ++R  +E A+   Q  EE
Sbjct: 2374 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2416



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 43/360 (11%)

Query: 29   QRLRRLQDQLAARDALIARLRARLAAL---EGDAAPSLVDALLEQVARFREQLRRQEGGA 85
            + L  ++ Q+     L AR+ A   AL   + D     +    E++ +  E+  R    A
Sbjct: 2365 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2424

Query: 86   AEA----QMRQEIERLTERLEEK--EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAA 139
             EA    Q+ +E       L EK  + +MQ +    + + E E++  ++ +A+ +  R  
Sbjct: 2425 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2484

Query: 140  SDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG-- 195
             D   + + LA ET   +RTL A     Q   +   E +  +  V E S  Q+   +   
Sbjct: 2485 EDKEQMAQQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2541

Query: 196  --HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
                  + + EKL       ++KVT V+ L  + Q                    Q  H+
Sbjct: 2542 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------------QSDHD 2581

Query: 254  PELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR-DAALERVQMLEQQILAYKDDFMS 312
             E +R+ I+ L R+ E+   +   ++ +    +T + +  L+  Q L+Q  L+ KD  + 
Sbjct: 2582 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2641

Query: 313  ERADRERAQSRIQELEE----KVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368
                 E+ ++++++L +    K   L  +   +Q   E +  R+ A  + A+    +A E
Sbjct: 2642 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2701



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 86/341 (25%), Positives = 138/341 (40%), Gaps = 26/341 (7%)

Query: 26   EAGQRLRR-LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84
            E  +RLRR +QD+   +      L +R+ A E +AA     AL     +  E+LR Q   
Sbjct: 1631 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRAL-----QALEELRLQ--- 1681

Query: 85   AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG----ERARAAS 140
            A EA+      RL +   E+ R++Q  L   Q   E E+   R S AE     ER+    
Sbjct: 1682 AEEAE-----RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1736

Query: 141  DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV- 199
             V    L  E  + R    A A   +  A+   ER   + N   R   Q+E      S+ 
Sbjct: 1737 HVAVAQLREEAER-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1795

Query: 200  QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259
            Q+  EK +EE     ++    E+   + +       E  R L       ++  E EL+R 
Sbjct: 1796 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR- 1854

Query: 260  EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRER 319
                L  + E+       +++ELA  +    AA ++ Q LE ++   + +     A + R
Sbjct: 1855 ----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1910

Query: 320  AQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360
            A+   +   EK    L   + R      +A R+ A ++ AK
Sbjct: 1911 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1951



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 32/300 (10%)

Query: 27   AGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAA 86
            A ++LR+  +Q AAR     R +A  AAL    A    DA +E+  +F EQ  RQ+    
Sbjct: 2271 AAEKLRKEAEQEAAR-----RAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---- 2318

Query: 87   EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRS 146
             AQ+ QE+  L  +LEE + +   L        ++E+  L+    E  R R+  +    S
Sbjct: 2319 -AQVEQELTTLRLQLEETDHQKNLL--------DEELQRLKAEATEAARQRSQVEEELFS 2369

Query: 147  LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKL 206
            +  +  +L +         ++ A  L ++ + QR + E +    +  +    +    ++ 
Sbjct: 2370 VRVQMEELSKLKARIE--AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2427

Query: 207  QEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNR 266
                +L ++ +     L  K  +      +    L A+   LQ   + EL +++  RL  
Sbjct: 2428 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ--QQKELAQEQARRLQE 2485

Query: 267  QLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326
              E+       + Q+LA         LE  +  + ++ A  +      A+  RAQ+R +E
Sbjct: 2486 DKEQ-------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2538



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 84/403 (20%), Positives = 165/403 (40%), Gaps = 32/403 (7%)

Query: 26   EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85
            EA +R +  +  +  R+     L  +    EG A   L  A  +++ R R +   ++G  
Sbjct: 1809 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAET--EQGEQ 1864

Query: 86   AEAQMRQEIERLTERLEEKEREMQQLLSQPQHER-EKEVVLLRRSMAEGERARAASDVLC 144
                + +E+ RL        ++ Q+L ++    R E EV+L  ++ AE E +R+ S+   
Sbjct: 1865 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE-EESRSTSEKSK 1923

Query: 145  RSLANETHQLR---------RTLTATAHMCQHLAK--CLDERQHAQRNVGERSPDQSEHT 193
            + L  E  + R         R L   A   + LA+     +R  A+R + E+     E T
Sbjct: 1924 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1983

Query: 194  DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
               T  +  +++ + EN  L++     ED   + +R      ++   +  +L  L+   +
Sbjct: 1984 RLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 2040

Query: 254  PELMR-----KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308
             EL R     ++  R  RQ+EE+I       ++ AA +   +  L R++   +  L  K+
Sbjct: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 2100

Query: 309  DFMSE-------RADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKY 361
                E        A+ ER +   +E  +K  +   + + ++ +   +  R+ A  + A+ 
Sbjct: 2101 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2160

Query: 362  LAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQ 404
            L   A +            +Q+     E  H  A Q+ + +LQ
Sbjct: 2161 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2203



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 75/329 (22%), Positives = 133/329 (40%), Gaps = 51/329 (15%)

Query: 26   EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ---- 81
            EA QR RRL++Q A   A I    A+L     D+       L+E   R R Q+  +    
Sbjct: 2010 EAFQR-RRLEEQAAQHKADIEERLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILAL 2067

Query: 82   -----EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERA 136
                 +  A +A++  E+ R+    E+  R  +Q         E E    R+  AE ER 
Sbjct: 2068 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA--------ELEAARQRQLAAEEERR 2119

Query: 137  RA-ASDVLCRSLANETHQLRRT---------LTATAHMCQHLAKCLDERQHAQRNVGERS 186
            R  A + + +SLA E    R+          L A     + L +  ++    Q  + + +
Sbjct: 2120 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2179

Query: 187  PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246
              +    +      +V +K QE  + L+Q+ + ++ L  + +    + +E      A+  
Sbjct: 2180 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEA 2233

Query: 247  GLQIPHEPELMRKEIS---RLNRQLEEKINDCA-----------EVKQELAASRTARDAA 292
             +Q   E    R+++    RL +  EE+    A           E +QE A    A  AA
Sbjct: 2234 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2293

Query: 293  LERVQMLEQQILAYKDDFMSERADRERAQ 321
            L + Q  + ++  +K    +E+  R++AQ
Sbjct: 2294 LRQKQAADAEMEKHKK--FAEQTLRQKAQ 2320



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 89/393 (22%), Positives = 165/393 (41%), Gaps = 72/393 (18%)

Query: 33   RLQDQLAARDALIARLRARLAAL---------EGDAAPSLVDALLEQVARFREQL----- 78
            RLQ +   RD  + R R R+A L         + D     ++ L  Q+  +RE       
Sbjct: 1299 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1358

Query: 79   ------RRQE---------GGAAEAQMRQE------IERLTERLEEKEREMQQLLSQPQH 117
                  RRQE           A   Q+RQE      IER  E++EE +R  +Q ++  + 
Sbjct: 1359 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK- 1417

Query: 118  EREKEVVLLR------RSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKC 171
            + E ++V  +       S A+  + ++ S+ + +   +         T T+   + +++ 
Sbjct: 1418 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1477

Query: 172  LDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK---LQEENRLLK-QKVTHVEDLNAKW 227
            L   +  +R   ++  ++ E       V++ +EK   L E +   K Q     ++L  + 
Sbjct: 1478 LRRMEEEERLAEQQRAEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1534

Query: 228  QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287
            Q     R+E       Q R +Q         +E+ +L +  E +I   A+ +Q  AA R+
Sbjct: 1535 QEEVVRREEAAVDAQQQKRSIQ---------EELQQLRQSSEAEIQ--AKARQAEAAERS 1583

Query: 288  ----ARDAALERVQM--LEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV--- 338
                  +  + R+Q+   E+Q    + +  + RA  E A+++ ++ +E+   L  QV   
Sbjct: 1584 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1643

Query: 339  SWRQDSREPD-AGRIHAGSKTA--KYLAADALE 368
            S R+   E + A R+ A ++ A  K  A  ALE
Sbjct: 1644 SQRKRQAEVELASRVKAEAEAAREKQRALQALE 1676



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 46/353 (13%)

Query: 11   EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIAR--LRARLAAL-EGDAAPSLVDAL 67
            EEA R + A      +   RLR+L ++  A+   +A   L+ ++ A+ E     +  + L
Sbjct: 2415 EEAARLSVAA-----QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2469

Query: 68   LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124
             +Q    +EQ RR         ++++ E++ ++L E+ +  Q+ L    Q Q E   E  
Sbjct: 2470 QQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2520

Query: 125  LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184
             L+  +AE  RA+A ++   +    +  ++   L  T    Q     L +    QR   +
Sbjct: 2521 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSD 2579

Query: 185  RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW--QRYNASRDEYVRGLH 242
               D     +    ++   EKLQ+E +LL+ K   ++ +  +   Q   A +  ++    
Sbjct: 2580 H--DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2637

Query: 243  AQLRGLQIPHEP-----ELMRKEISRLNRQLEEKINDCAEVKQE----LAASRTAR---- 289
            + L+  +   +      +L + E+++  +  EE+     +++QE    +A+   AR    
Sbjct: 2638 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2697

Query: 290  ------DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
                      E +Q LEQQ    +++ ++E   R R Q ++ E E+  A+L H
Sbjct: 2698 EAEEGVRRKQEELQQLEQQ-RRQQEELLAEENQRLREQLQLLE-EQHRAALAH 2748



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 98/393 (24%), Positives = 156/393 (39%), Gaps = 42/393 (10%)

Query: 62   SLVDALLEQVARF-REQLRR--QEGGAAEAQMRQEIERLTE--RLEEKEREMQQLLSQPQ 116
            S +  L  Q  +F  E LRR  +E   AE Q  +E ERL E     EK+R++ +  +Q +
Sbjct: 1461 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1520

Query: 117  HEREKEVVLLRRSMAEG----ERARAASDVLCRSLANETHQLRRTLTA-------TAHMC 165
             + E+E   L++ M E     E A   +    RS+  E  QLR++  A        A   
Sbjct: 1521 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1580

Query: 166  QHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225
            +     ++E     R   E +  Q    +G   +Q++  + +E     +Q     E L  
Sbjct: 1581 ERSRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRR 1638

Query: 226  KWQRYNASRDEYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAA 284
            + Q      DE  R   A++    ++  E E  R E  R  + LEE      E ++ L  
Sbjct: 1639 QVQ------DESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1691

Query: 285  SRTAR----DAALERVQ-MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339
            +   R      ALE  Q   E ++ + +  F  + A  ER+   +QE    VA L  +  
Sbjct: 1692 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAE 1748

Query: 340  WR-QDSREPDAGRIHAGSKTAKY--LAADALELMVPG---GWRPGTGSQQPEPPAEGGHP 393
             R Q   E +  R  A  +  ++   A +AL L +       +      + E   E    
Sbjct: 1749 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1808

Query: 394  GAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAE 426
             A +RG+ + Q     Q    EQ  E  R +AE
Sbjct: 1809 EARRRGKAEEQAVR--QRELAEQELEKQRQLAE 1839


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 84/343 (24%), Positives = 141/343 (41%), Gaps = 50/343 (14%)

Query: 11   EEAPRAAAALCTLYHEAGQRLR----RLQDQLAARDALIARLRARLAALEGDAAPSLVDA 66
            E+A   AA    L  E  +R R    R+Q  LAA +    + +A L  +E       + A
Sbjct: 1941 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER------LKA 1994

Query: 67   LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEE---------KEREMQQLLSQPQH 117
             +E+  R RE  R ++  A + Q+ QE  +   + EE         KE+E+QQ L Q Q 
Sbjct: 1995 KVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2052

Query: 118  EREK---EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE 174
              ++   E    RR+  E E AR  ++        E  Q RR +     + Q   +    
Sbjct: 2053 VLDQLRGEAEAARRAAEEAEEARVQAE-------REAAQSRRQVEEAERLKQSAEEQAQA 2105

Query: 175  RQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLN------AKWQ 228
            R  AQ    E+   ++E        Q    + Q E   L+QK     ++        +  
Sbjct: 2106 RAQAQA-AAEKLRKEAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2156

Query: 229  RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288
            R  A  ++ +  L  QL   +  H+  L+ +E+ RL  +  E     ++V++EL + R  
Sbjct: 2157 RQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2214

Query: 289  RD--AALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEE 329
             +  + L+     E + L  +D   ++R  +E A+   Q  EE
Sbjct: 2215 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2257



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 43/360 (11%)

Query: 29   QRLRRLQDQLAARDALIARLRARLAAL---EGDAAPSLVDALLEQVARFREQLRRQEGGA 85
            + L  ++ Q+     L AR+ A   AL   + D     +    E++ +  E+  R    A
Sbjct: 2206 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2265

Query: 86   AEA----QMRQEIERLTERLEEK--EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAA 139
             EA    Q+ +E       L EK  + +MQ +    + + E E++  ++ +A+ +  R  
Sbjct: 2266 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2325

Query: 140  SDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG-- 195
             D   + + LA ET   +RTL A     Q   +   E +  +  V E S  Q+   +   
Sbjct: 2326 EDKEQMAQQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2382

Query: 196  --HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
                  + + EKL       ++KVT V+ L  + Q                    Q  H+
Sbjct: 2383 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------------QSDHD 2422

Query: 254  PELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR-DAALERVQMLEQQILAYKDDFMS 312
             E +R+ I+ L R+ E+   +   ++ +    +T + +  L+  Q L+Q  L+ KD  + 
Sbjct: 2423 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2482

Query: 313  ERADRERAQSRIQELEE----KVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368
                 E+ ++++++L +    K   L  +   +Q   E +  R+ A  + A+    +A E
Sbjct: 2483 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2542



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 86/341 (25%), Positives = 138/341 (40%), Gaps = 26/341 (7%)

Query: 26   EAGQRLRR-LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84
            E  +RLRR +QD+   +      L +R+ A E +AA     AL     +  E+LR Q   
Sbjct: 1472 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRAL-----QALEELRLQ--- 1522

Query: 85   AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG----ERARAAS 140
            A EA+      RL +   E+ R++Q  L   Q   E E+   R S AE     ER+    
Sbjct: 1523 AEEAE-----RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1577

Query: 141  DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV- 199
             V    L  E  + R    A A   +  A+   ER   + N   R   Q+E      S+ 
Sbjct: 1578 HVAVAQLREEAER-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1636

Query: 200  QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259
            Q+  EK +EE     ++    E+   + +       E  R L       ++  E EL+R 
Sbjct: 1637 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR- 1695

Query: 260  EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRER 319
                L  + E+       +++ELA  +    AA ++ Q LE ++   + +     A + R
Sbjct: 1696 ----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1751

Query: 320  AQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360
            A+   +   EK    L   + R      +A R+ A ++ AK
Sbjct: 1752 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1792



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 32/300 (10%)

Query: 27   AGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAA 86
            A ++LR+  +Q AAR     R +A  AAL    A    DA +E+  +F EQ  RQ+    
Sbjct: 2112 AAEKLRKEAEQEAAR-----RAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---- 2159

Query: 87   EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRS 146
             AQ+ QE+  L  +LEE + +   L        ++E+  L+    E  R R+  +    S
Sbjct: 2160 -AQVEQELTTLRLQLEETDHQKNLL--------DEELQRLKAEATEAARQRSQVEEELFS 2210

Query: 147  LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKL 206
            +  +  +L +         ++ A  L ++ + QR + E +    +  +    +    ++ 
Sbjct: 2211 VRVQMEELSKLKARIE--AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2268

Query: 207  QEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNR 266
                +L ++ +     L  K  +      +    L A+   LQ   + EL +++  RL  
Sbjct: 2269 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ--QQKELAQEQARRLQE 2326

Query: 267  QLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326
              E+       + Q+LA         LE  +  + ++ A  +      A+  RAQ+R +E
Sbjct: 2327 DKEQ-------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2379



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 84/403 (20%), Positives = 165/403 (40%), Gaps = 32/403 (7%)

Query: 26   EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85
            EA +R +  +  +  R+     L  +    EG A   L  A  +++ R R +   ++G  
Sbjct: 1650 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAET--EQGEQ 1705

Query: 86   AEAQMRQEIERLTERLEEKEREMQQLLSQPQHER-EKEVVLLRRSMAEGERARAASDVLC 144
                + +E+ RL        ++ Q+L ++    R E EV+L  ++ AE E +R+ S+   
Sbjct: 1706 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE-EESRSTSEKSK 1764

Query: 145  RSLANETHQLR---------RTLTATAHMCQHLAK--CLDERQHAQRNVGERSPDQSEHT 193
            + L  E  + R         R L   A   + LA+     +R  A+R + E+     E T
Sbjct: 1765 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1824

Query: 194  DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
               T  +  +++ + EN  L++     ED   + +R      ++   +  +L  L+   +
Sbjct: 1825 RLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1881

Query: 254  PELMR-----KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308
             EL R     ++  R  RQ+EE+I       ++ AA +   +  L R++   +  L  K+
Sbjct: 1882 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1941

Query: 309  DFMSE-------RADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKY 361
                E        A+ ER +   +E  +K  +   + + ++ +   +  R+ A  + A+ 
Sbjct: 1942 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2001

Query: 362  LAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQ 404
            L   A +            +Q+     E  H  A Q+ + +LQ
Sbjct: 2002 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2044



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 75/329 (22%), Positives = 133/329 (40%), Gaps = 51/329 (15%)

Query: 26   EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ---- 81
            EA QR RRL++Q A   A I    A+L     D+       L+E   R R Q+  +    
Sbjct: 1851 EAFQR-RRLEEQAAQHKADIEERLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILAL 1908

Query: 82   -----EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERA 136
                 +  A +A++  E+ R+    E+  R  +Q         E E    R+  AE ER 
Sbjct: 1909 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA--------ELEAARQRQLAAEEERR 1960

Query: 137  RA-ASDVLCRSLANETHQLRRT---------LTATAHMCQHLAKCLDERQHAQRNVGERS 186
            R  A + + +SLA E    R+          L A     + L +  ++    Q  + + +
Sbjct: 1961 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2020

Query: 187  PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246
              +    +      +V +K QE  + L+Q+ + ++ L  + +    + +E      A+  
Sbjct: 2021 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEA 2074

Query: 247  GLQIPHEPELMRKEIS---RLNRQLEEKINDCA-----------EVKQELAASRTARDAA 292
             +Q   E    R+++    RL +  EE+    A           E +QE A    A  AA
Sbjct: 2075 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2134

Query: 293  LERVQMLEQQILAYKDDFMSERADRERAQ 321
            L + Q  + ++  +K    +E+  R++AQ
Sbjct: 2135 LRQKQAADAEMEKHKK--FAEQTLRQKAQ 2161



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 89/393 (22%), Positives = 165/393 (41%), Gaps = 72/393 (18%)

Query: 33   RLQDQLAARDALIARLRARLAAL---------EGDAAPSLVDALLEQVARFREQL----- 78
            RLQ +   RD  + R R R+A L         + D     ++ L  Q+  +RE       
Sbjct: 1140 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1199

Query: 79   ------RRQE---------GGAAEAQMRQE------IERLTERLEEKEREMQQLLSQPQH 117
                  RRQE           A   Q+RQE      IER  E++EE +R  +Q ++  + 
Sbjct: 1200 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK- 1258

Query: 118  EREKEVVLLR------RSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKC 171
            + E ++V  +       S A+  + ++ S+ + +   +         T T+   + +++ 
Sbjct: 1259 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1318

Query: 172  LDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK---LQEENRLLK-QKVTHVEDLNAKW 227
            L   +  +R   ++  ++ E       V++ +EK   L E +   K Q     ++L  + 
Sbjct: 1319 LRRMEEEERLAEQQRAEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1375

Query: 228  QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287
            Q     R+E       Q R +Q         +E+ +L +  E +I   A+ +Q  AA R+
Sbjct: 1376 QEEVVRREEAAVDAQQQKRSIQ---------EELQQLRQSSEAEIQ--AKARQAEAAERS 1424

Query: 288  ----ARDAALERVQM--LEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV--- 338
                  +  + R+Q+   E+Q    + +  + RA  E A+++ ++ +E+   L  QV   
Sbjct: 1425 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1484

Query: 339  SWRQDSREPD-AGRIHAGSKTA--KYLAADALE 368
            S R+   E + A R+ A ++ A  K  A  ALE
Sbjct: 1485 SQRKRQAEVELASRVKAEAEAAREKQRALQALE 1517



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 46/353 (13%)

Query: 11   EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIAR--LRARLAAL-EGDAAPSLVDAL 67
            EEA R + A      +   RLR+L ++  A+   +A   L+ ++ A+ E     +  + L
Sbjct: 2256 EEAARLSVAA-----QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2310

Query: 68   LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124
             +Q    +EQ RR         ++++ E++ ++L E+ +  Q+ L    Q Q E   E  
Sbjct: 2311 QQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2361

Query: 125  LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184
             L+  +AE  RA+A ++   +    +  ++   L  T    Q     L +    QR   +
Sbjct: 2362 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSD 2420

Query: 185  RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW--QRYNASRDEYVRGLH 242
               D     +    ++   EKLQ+E +LL+ K   ++ +  +   Q   A +  ++    
Sbjct: 2421 H--DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2478

Query: 243  AQLRGLQIPHEP-----ELMRKEISRLNRQLEEKINDCAEVKQE----LAASRTAR---- 289
            + L+  +   +      +L + E+++  +  EE+     +++QE    +A+   AR    
Sbjct: 2479 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2538

Query: 290  ------DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
                      E +Q LEQQ    +++ ++E   R R Q ++ E E+  A+L H
Sbjct: 2539 EAEEGVRRKQEELQQLEQQ-RRQQEELLAEENQRLREQLQLLE-EQHRAALAH 2589



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 98/393 (24%), Positives = 156/393 (39%), Gaps = 42/393 (10%)

Query: 62   SLVDALLEQVARF-REQLRR--QEGGAAEAQMRQEIERLTE--RLEEKEREMQQLLSQPQ 116
            S +  L  Q  +F  E LRR  +E   AE Q  +E ERL E     EK+R++ +  +Q +
Sbjct: 1302 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1361

Query: 117  HEREKEVVLLRRSMAEG----ERARAASDVLCRSLANETHQLRRTLTA-------TAHMC 165
             + E+E   L++ M E     E A   +    RS+  E  QLR++  A        A   
Sbjct: 1362 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1421

Query: 166  QHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225
            +     ++E     R   E +  Q    +G   +Q++  + +E     +Q     E L  
Sbjct: 1422 ERSRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRR 1479

Query: 226  KWQRYNASRDEYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAA 284
            + Q      DE  R   A++    ++  E E  R E  R  + LEE      E ++ L  
Sbjct: 1480 QVQ------DESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1532

Query: 285  SRTAR----DAALERVQ-MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339
            +   R      ALE  Q   E ++ + +  F  + A  ER+   +QE    VA L  +  
Sbjct: 1533 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAE 1589

Query: 340  WR-QDSREPDAGRIHAGSKTAKY--LAADALELMVPG---GWRPGTGSQQPEPPAEGGHP 393
             R Q   E +  R  A  +  ++   A +AL L +       +      + E   E    
Sbjct: 1590 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1649

Query: 394  GAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAE 426
             A +RG+ + Q     Q    EQ  E  R +AE
Sbjct: 1650 EARRRGKAEEQAVR--QRELAEQELEKQRQLAE 1680


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 84/343 (24%), Positives = 141/343 (41%), Gaps = 50/343 (14%)

Query: 11   EEAPRAAAALCTLYHEAGQRLR----RLQDQLAARDALIARLRARLAALEGDAAPSLVDA 66
            E+A   AA    L  E  +R R    R+Q  LAA +    + +A L  +E       + A
Sbjct: 1949 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER------LKA 2002

Query: 67   LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEE---------KEREMQQLLSQPQH 117
             +E+  R RE  R ++  A + Q+ QE  +   + EE         KE+E+QQ L Q Q 
Sbjct: 2003 KVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2060

Query: 118  EREK---EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE 174
              ++   E    RR+  E E AR  ++        E  Q RR +     + Q   +    
Sbjct: 2061 VLDQLRGEAEAARRAAEEAEEARVQAE-------REAAQSRRQVEEAERLKQSAEEQAQA 2113

Query: 175  RQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLN------AKWQ 228
            R  AQ    E+   ++E        Q    + Q E   L+QK     ++        +  
Sbjct: 2114 RAQAQA-AAEKLRKEAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2164

Query: 229  RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288
            R  A  ++ +  L  QL   +  H+  L+ +E+ RL  +  E     ++V++EL + R  
Sbjct: 2165 RQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2222

Query: 289  RD--AALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEE 329
             +  + L+     E + L  +D   ++R  +E A+   Q  EE
Sbjct: 2223 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2265



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 43/360 (11%)

Query: 29   QRLRRLQDQLAARDALIARLRARLAAL---EGDAAPSLVDALLEQVARFREQLRRQEGGA 85
            + L  ++ Q+     L AR+ A   AL   + D     +    E++ +  E+  R    A
Sbjct: 2214 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2273

Query: 86   AEA----QMRQEIERLTERLEEK--EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAA 139
             EA    Q+ +E       L EK  + +MQ +    + + E E++  ++ +A+ +  R  
Sbjct: 2274 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2333

Query: 140  SDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG-- 195
             D   + + LA ET   +RTL A     Q   +   E +  +  V E S  Q+   +   
Sbjct: 2334 EDKEQMAQQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2390

Query: 196  --HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
                  + + EKL       ++KVT V+ L  + Q                    Q  H+
Sbjct: 2391 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------------QSDHD 2430

Query: 254  PELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR-DAALERVQMLEQQILAYKDDFMS 312
             E +R+ I+ L R+ E+   +   ++ +    +T + +  L+  Q L+Q  L+ KD  + 
Sbjct: 2431 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2490

Query: 313  ERADRERAQSRIQELEE----KVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368
                 E+ ++++++L +    K   L  +   +Q   E +  R+ A  + A+    +A E
Sbjct: 2491 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2550



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 86/341 (25%), Positives = 138/341 (40%), Gaps = 26/341 (7%)

Query: 26   EAGQRLRR-LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84
            E  +RLRR +QD+   +      L +R+ A E +AA     AL     +  E+LR Q   
Sbjct: 1480 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRAL-----QALEELRLQ--- 1530

Query: 85   AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG----ERARAAS 140
            A EA+      RL +   E+ R++Q  L   Q   E E+   R S AE     ER+    
Sbjct: 1531 AEEAE-----RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1585

Query: 141  DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV- 199
             V    L  E  + R    A A   +  A+   ER   + N   R   Q+E      S+ 
Sbjct: 1586 HVAVAQLREEAER-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1644

Query: 200  QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259
            Q+  EK +EE     ++    E+   + +       E  R L       ++  E EL+R 
Sbjct: 1645 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR- 1703

Query: 260  EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRER 319
                L  + E+       +++ELA  +    AA ++ Q LE ++   + +     A + R
Sbjct: 1704 ----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1759

Query: 320  AQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360
            A+   +   EK    L   + R      +A R+ A ++ AK
Sbjct: 1760 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1800



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 32/300 (10%)

Query: 27   AGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAA 86
            A ++LR+  +Q AAR     R +A  AAL    A    DA +E+  +F EQ  RQ+    
Sbjct: 2120 AAEKLRKEAEQEAAR-----RAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---- 2167

Query: 87   EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRS 146
             AQ+ QE+  L  +LEE + +   L        ++E+  L+    E  R R+  +    S
Sbjct: 2168 -AQVEQELTTLRLQLEETDHQKNLL--------DEELQRLKAEATEAARQRSQVEEELFS 2218

Query: 147  LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKL 206
            +  +  +L +         ++ A  L ++ + QR + E +    +  +    +    ++ 
Sbjct: 2219 VRVQMEELSKLKARIE--AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2276

Query: 207  QEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNR 266
                +L ++ +     L  K  +      +    L A+   LQ   + EL +++  RL  
Sbjct: 2277 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ--QQKELAQEQARRLQE 2334

Query: 267  QLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326
              E+       + Q+LA         LE  +  + ++ A  +      A+  RAQ+R +E
Sbjct: 2335 DKEQ-------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2387



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 84/403 (20%), Positives = 165/403 (40%), Gaps = 32/403 (7%)

Query: 26   EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85
            EA +R +  +  +  R+     L  +    EG A   L  A  +++ R R +   ++G  
Sbjct: 1658 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAET--EQGEQ 1713

Query: 86   AEAQMRQEIERLTERLEEKEREMQQLLSQPQHER-EKEVVLLRRSMAEGERARAASDVLC 144
                + +E+ RL        ++ Q+L ++    R E EV+L  ++ AE E +R+ S+   
Sbjct: 1714 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE-EESRSTSEKSK 1772

Query: 145  RSLANETHQLR---------RTLTATAHMCQHLAK--CLDERQHAQRNVGERSPDQSEHT 193
            + L  E  + R         R L   A   + LA+     +R  A+R + E+     E T
Sbjct: 1773 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1832

Query: 194  DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
               T  +  +++ + EN  L++     ED   + +R      ++   +  +L  L+   +
Sbjct: 1833 RLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1889

Query: 254  PELMR-----KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308
             EL R     ++  R  RQ+EE+I       ++ AA +   +  L R++   +  L  K+
Sbjct: 1890 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1949

Query: 309  DFMSE-------RADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKY 361
                E        A+ ER +   +E  +K  +   + + ++ +   +  R+ A  + A+ 
Sbjct: 1950 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2009

Query: 362  LAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQ 404
            L   A +            +Q+     E  H  A Q+ + +LQ
Sbjct: 2010 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2052



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 75/329 (22%), Positives = 133/329 (40%), Gaps = 51/329 (15%)

Query: 26   EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ---- 81
            EA QR RRL++Q A   A I    A+L     D+       L+E   R R Q+  +    
Sbjct: 1859 EAFQR-RRLEEQAAQHKADIEERLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILAL 1916

Query: 82   -----EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERA 136
                 +  A +A++  E+ R+    E+  R  +Q         E E    R+  AE ER 
Sbjct: 1917 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA--------ELEAARQRQLAAEEERR 1968

Query: 137  RA-ASDVLCRSLANETHQLRRT---------LTATAHMCQHLAKCLDERQHAQRNVGERS 186
            R  A + + +SLA E    R+          L A     + L +  ++    Q  + + +
Sbjct: 1969 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2028

Query: 187  PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246
              +    +      +V +K QE  + L+Q+ + ++ L  + +    + +E      A+  
Sbjct: 2029 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEA 2082

Query: 247  GLQIPHEPELMRKEIS---RLNRQLEEKINDCA-----------EVKQELAASRTARDAA 292
             +Q   E    R+++    RL +  EE+    A           E +QE A    A  AA
Sbjct: 2083 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2142

Query: 293  LERVQMLEQQILAYKDDFMSERADRERAQ 321
            L + Q  + ++  +K    +E+  R++AQ
Sbjct: 2143 LRQKQAADAEMEKHKK--FAEQTLRQKAQ 2169



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 89/393 (22%), Positives = 165/393 (41%), Gaps = 72/393 (18%)

Query: 33   RLQDQLAARDALIARLRARLAAL---------EGDAAPSLVDALLEQVARFREQL----- 78
            RLQ +   RD  + R R R+A L         + D     ++ L  Q+  +RE       
Sbjct: 1148 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1207

Query: 79   ------RRQE---------GGAAEAQMRQE------IERLTERLEEKEREMQQLLSQPQH 117
                  RRQE           A   Q+RQE      IER  E++EE +R  +Q ++  + 
Sbjct: 1208 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK- 1266

Query: 118  EREKEVVLLR------RSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKC 171
            + E ++V  +       S A+  + ++ S+ + +   +         T T+   + +++ 
Sbjct: 1267 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1326

Query: 172  LDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK---LQEENRLLK-QKVTHVEDLNAKW 227
            L   +  +R   ++  ++ E       V++ +EK   L E +   K Q     ++L  + 
Sbjct: 1327 LRRMEEEERLAEQQRAEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1383

Query: 228  QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287
            Q     R+E       Q R +Q         +E+ +L +  E +I   A+ +Q  AA R+
Sbjct: 1384 QEEVVRREEAAVDAQQQKRSIQ---------EELQQLRQSSEAEIQ--AKARQAEAAERS 1432

Query: 288  ----ARDAALERVQM--LEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV--- 338
                  +  + R+Q+   E+Q    + +  + RA  E A+++ ++ +E+   L  QV   
Sbjct: 1433 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1492

Query: 339  SWRQDSREPD-AGRIHAGSKTA--KYLAADALE 368
            S R+   E + A R+ A ++ A  K  A  ALE
Sbjct: 1493 SQRKRQAEVELASRVKAEAEAAREKQRALQALE 1525



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 46/353 (13%)

Query: 11   EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIAR--LRARLAAL-EGDAAPSLVDAL 67
            EEA R + A      +   RLR+L ++  A+   +A   L+ ++ A+ E     +  + L
Sbjct: 2264 EEAARLSVAA-----QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2318

Query: 68   LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124
             +Q    +EQ RR         ++++ E++ ++L E+ +  Q+ L    Q Q E   E  
Sbjct: 2319 QQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2369

Query: 125  LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184
             L+  +AE  RA+A ++   +    +  ++   L  T    Q     L +    QR   +
Sbjct: 2370 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSD 2428

Query: 185  RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW--QRYNASRDEYVRGLH 242
               D     +    ++   EKLQ+E +LL+ K   ++ +  +   Q   A +  ++    
Sbjct: 2429 H--DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2486

Query: 243  AQLRGLQIPHEP-----ELMRKEISRLNRQLEEKINDCAEVKQE----LAASRTAR---- 289
            + L+  +   +      +L + E+++  +  EE+     +++QE    +A+   AR    
Sbjct: 2487 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2546

Query: 290  ------DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
                      E +Q LEQQ    +++ ++E   R R Q ++ E E+  A+L H
Sbjct: 2547 EAEEGVRRKQEELQQLEQQ-RRQQEELLAEENQRLREQLQLLE-EQHRAALAH 2597



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 98/393 (24%), Positives = 156/393 (39%), Gaps = 42/393 (10%)

Query: 62   SLVDALLEQVARF-REQLRR--QEGGAAEAQMRQEIERLTE--RLEEKEREMQQLLSQPQ 116
            S +  L  Q  +F  E LRR  +E   AE Q  +E ERL E     EK+R++ +  +Q +
Sbjct: 1310 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1369

Query: 117  HEREKEVVLLRRSMAEG----ERARAASDVLCRSLANETHQLRRTLTA-------TAHMC 165
             + E+E   L++ M E     E A   +    RS+  E  QLR++  A        A   
Sbjct: 1370 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1429

Query: 166  QHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225
            +     ++E     R   E +  Q    +G   +Q++  + +E     +Q     E L  
Sbjct: 1430 ERSRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRR 1487

Query: 226  KWQRYNASRDEYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAA 284
            + Q      DE  R   A++    ++  E E  R E  R  + LEE      E ++ L  
Sbjct: 1488 QVQ------DESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1540

Query: 285  SRTAR----DAALERVQ-MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339
            +   R      ALE  Q   E ++ + +  F  + A  ER+   +QE    VA L  +  
Sbjct: 1541 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAE 1597

Query: 340  WR-QDSREPDAGRIHAGSKTAKY--LAADALELMVPG---GWRPGTGSQQPEPPAEGGHP 393
             R Q   E +  R  A  +  ++   A +AL L +       +      + E   E    
Sbjct: 1598 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1657

Query: 394  GAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAE 426
             A +RG+ + Q     Q    EQ  E  R +AE
Sbjct: 1658 EARRRGKAEEQAVR--QRELAEQELEKQRQLAE 1688


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 84/343 (24%), Positives = 141/343 (41%), Gaps = 50/343 (14%)

Query: 11   EEAPRAAAALCTLYHEAGQRLR----RLQDQLAARDALIARLRARLAALEGDAAPSLVDA 66
            E+A   AA    L  E  +R R    R+Q  LAA +    + +A L  +E       + A
Sbjct: 1990 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER------LKA 2043

Query: 67   LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEE---------KEREMQQLLSQPQH 117
             +E+  R RE  R ++  A + Q+ QE  +   + EE         KE+E+QQ L Q Q 
Sbjct: 2044 KVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2101

Query: 118  EREK---EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE 174
              ++   E    RR+  E E AR  ++        E  Q RR +     + Q   +    
Sbjct: 2102 VLDQLRGEAEAARRAAEEAEEARVQAE-------REAAQSRRQVEEAERLKQSAEEQAQA 2154

Query: 175  RQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLN------AKWQ 228
            R  AQ    E+   ++E        Q    + Q E   L+QK     ++        +  
Sbjct: 2155 RAQAQA-AAEKLRKEAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2205

Query: 229  RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288
            R  A  ++ +  L  QL   +  H+  L+ +E+ RL  +  E     ++V++EL + R  
Sbjct: 2206 RQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2263

Query: 289  RD--AALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEE 329
             +  + L+     E + L  +D   ++R  +E A+   Q  EE
Sbjct: 2264 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2306



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 43/360 (11%)

Query: 29   QRLRRLQDQLAARDALIARLRARLAAL---EGDAAPSLVDALLEQVARFREQLRRQEGGA 85
            + L  ++ Q+     L AR+ A   AL   + D     +    E++ +  E+  R    A
Sbjct: 2255 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2314

Query: 86   AEA----QMRQEIERLTERLEEK--EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAA 139
             EA    Q+ +E       L EK  + +MQ +    + + E E++  ++ +A+ +  R  
Sbjct: 2315 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2374

Query: 140  SDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG-- 195
             D   + + LA ET   +RTL A     Q   +   E +  +  V E S  Q+   +   
Sbjct: 2375 EDKEQMAQQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2431

Query: 196  --HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
                  + + EKL       ++KVT V+ L  + Q                    Q  H+
Sbjct: 2432 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------------QSDHD 2471

Query: 254  PELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR-DAALERVQMLEQQILAYKDDFMS 312
             E +R+ I+ L R+ E+   +   ++ +    +T + +  L+  Q L+Q  L+ KD  + 
Sbjct: 2472 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2531

Query: 313  ERADRERAQSRIQELEE----KVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368
                 E+ ++++++L +    K   L  +   +Q   E +  R+ A  + A+    +A E
Sbjct: 2532 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2591



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 86/341 (25%), Positives = 138/341 (40%), Gaps = 26/341 (7%)

Query: 26   EAGQRLRR-LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84
            E  +RLRR +QD+   +      L +R+ A E +AA     AL     +  E+LR Q   
Sbjct: 1521 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRAL-----QALEELRLQ--- 1571

Query: 85   AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG----ERARAAS 140
            A EA+      RL +   E+ R++Q  L   Q   E E+   R S AE     ER+    
Sbjct: 1572 AEEAE-----RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1626

Query: 141  DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV- 199
             V    L  E  + R    A A   +  A+   ER   + N   R   Q+E      S+ 
Sbjct: 1627 HVAVAQLREEAER-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1685

Query: 200  QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259
            Q+  EK +EE     ++    E+   + +       E  R L       ++  E EL+R 
Sbjct: 1686 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR- 1744

Query: 260  EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRER 319
                L  + E+       +++ELA  +    AA ++ Q LE ++   + +     A + R
Sbjct: 1745 ----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1800

Query: 320  AQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360
            A+   +   EK    L   + R      +A R+ A ++ AK
Sbjct: 1801 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1841



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 32/300 (10%)

Query: 27   AGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAA 86
            A ++LR+  +Q AAR     R +A  AAL    A    DA +E+  +F EQ  RQ+    
Sbjct: 2161 AAEKLRKEAEQEAAR-----RAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---- 2208

Query: 87   EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRS 146
             AQ+ QE+  L  +LEE + +   L        ++E+  L+    E  R R+  +    S
Sbjct: 2209 -AQVEQELTTLRLQLEETDHQKNLL--------DEELQRLKAEATEAARQRSQVEEELFS 2259

Query: 147  LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKL 206
            +  +  +L +         ++ A  L ++ + QR + E +    +  +    +    ++ 
Sbjct: 2260 VRVQMEELSKLKARIE--AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2317

Query: 207  QEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNR 266
                +L ++ +     L  K  +      +    L A+   LQ   + EL +++  RL  
Sbjct: 2318 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ--QQKELAQEQARRLQE 2375

Query: 267  QLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326
              E+       + Q+LA         LE  +  + ++ A  +      A+  RAQ+R +E
Sbjct: 2376 DKEQ-------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2428



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 84/403 (20%), Positives = 165/403 (40%), Gaps = 32/403 (7%)

Query: 26   EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85
            EA +R +  +  +  R+     L  +    EG A   L  A  +++ R R +   ++G  
Sbjct: 1699 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAET--EQGEQ 1754

Query: 86   AEAQMRQEIERLTERLEEKEREMQQLLSQPQHER-EKEVVLLRRSMAEGERARAASDVLC 144
                + +E+ RL        ++ Q+L ++    R E EV+L  ++ AE E +R+ S+   
Sbjct: 1755 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE-EESRSTSEKSK 1813

Query: 145  RSLANETHQLR---------RTLTATAHMCQHLAK--CLDERQHAQRNVGERSPDQSEHT 193
            + L  E  + R         R L   A   + LA+     +R  A+R + E+     E T
Sbjct: 1814 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1873

Query: 194  DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
               T  +  +++ + EN  L++     ED   + +R      ++   +  +L  L+   +
Sbjct: 1874 RLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1930

Query: 254  PELMR-----KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308
             EL R     ++  R  RQ+EE+I       ++ AA +   +  L R++   +  L  K+
Sbjct: 1931 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1990

Query: 309  DFMSE-------RADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKY 361
                E        A+ ER +   +E  +K  +   + + ++ +   +  R+ A  + A+ 
Sbjct: 1991 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2050

Query: 362  LAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQ 404
            L   A +            +Q+     E  H  A Q+ + +LQ
Sbjct: 2051 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2093



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 75/329 (22%), Positives = 133/329 (40%), Gaps = 51/329 (15%)

Query: 26   EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ---- 81
            EA QR RRL++Q A   A I    A+L     D+       L+E   R R Q+  +    
Sbjct: 1900 EAFQR-RRLEEQAAQHKADIEERLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILAL 1957

Query: 82   -----EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERA 136
                 +  A +A++  E+ R+    E+  R  +Q         E E    R+  AE ER 
Sbjct: 1958 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA--------ELEAARQRQLAAEEERR 2009

Query: 137  RA-ASDVLCRSLANETHQLRRT---------LTATAHMCQHLAKCLDERQHAQRNVGERS 186
            R  A + + +SLA E    R+          L A     + L +  ++    Q  + + +
Sbjct: 2010 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2069

Query: 187  PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246
              +    +      +V +K QE  + L+Q+ + ++ L  + +    + +E      A+  
Sbjct: 2070 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEA 2123

Query: 247  GLQIPHEPELMRKEIS---RLNRQLEEKINDCA-----------EVKQELAASRTARDAA 292
             +Q   E    R+++    RL +  EE+    A           E +QE A    A  AA
Sbjct: 2124 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2183

Query: 293  LERVQMLEQQILAYKDDFMSERADRERAQ 321
            L + Q  + ++  +K    +E+  R++AQ
Sbjct: 2184 LRQKQAADAEMEKHKK--FAEQTLRQKAQ 2210



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 89/393 (22%), Positives = 165/393 (41%), Gaps = 72/393 (18%)

Query: 33   RLQDQLAARDALIARLRARLAAL---------EGDAAPSLVDALLEQVARFREQL----- 78
            RLQ +   RD  + R R R+A L         + D     ++ L  Q+  +RE       
Sbjct: 1189 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1248

Query: 79   ------RRQE---------GGAAEAQMRQE------IERLTERLEEKEREMQQLLSQPQH 117
                  RRQE           A   Q+RQE      IER  E++EE +R  +Q ++  + 
Sbjct: 1249 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK- 1307

Query: 118  EREKEVVLLR------RSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKC 171
            + E ++V  +       S A+  + ++ S+ + +   +         T T+   + +++ 
Sbjct: 1308 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1367

Query: 172  LDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK---LQEENRLLK-QKVTHVEDLNAKW 227
            L   +  +R   ++  ++ E       V++ +EK   L E +   K Q     ++L  + 
Sbjct: 1368 LRRMEEEERLAEQQRAEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1424

Query: 228  QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287
            Q     R+E       Q R +Q         +E+ +L +  E +I   A+ +Q  AA R+
Sbjct: 1425 QEEVVRREEAAVDAQQQKRSIQ---------EELQQLRQSSEAEIQ--AKARQAEAAERS 1473

Query: 288  ----ARDAALERVQM--LEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV--- 338
                  +  + R+Q+   E+Q    + +  + RA  E A+++ ++ +E+   L  QV   
Sbjct: 1474 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1533

Query: 339  SWRQDSREPD-AGRIHAGSKTA--KYLAADALE 368
            S R+   E + A R+ A ++ A  K  A  ALE
Sbjct: 1534 SQRKRQAEVELASRVKAEAEAAREKQRALQALE 1566



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 46/353 (13%)

Query: 11   EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIAR--LRARLAAL-EGDAAPSLVDAL 67
            EEA R + A      +   RLR+L ++  A+   +A   L+ ++ A+ E     +  + L
Sbjct: 2305 EEAARLSVAA-----QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2359

Query: 68   LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124
             +Q    +EQ RR         ++++ E++ ++L E+ +  Q+ L    Q Q E   E  
Sbjct: 2360 QQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2410

Query: 125  LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184
             L+  +AE  RA+A ++   +    +  ++   L  T    Q     L +    QR   +
Sbjct: 2411 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSD 2469

Query: 185  RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW--QRYNASRDEYVRGLH 242
               D     +    ++   EKLQ+E +LL+ K   ++ +  +   Q   A +  ++    
Sbjct: 2470 H--DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2527

Query: 243  AQLRGLQIPHEP-----ELMRKEISRLNRQLEEKINDCAEVKQE----LAASRTAR---- 289
            + L+  +   +      +L + E+++  +  EE+     +++QE    +A+   AR    
Sbjct: 2528 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2587

Query: 290  ------DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
                      E +Q LEQQ    +++ ++E   R R Q ++ E E+  A+L H
Sbjct: 2588 EAEEGVRRKQEELQQLEQQ-RRQQEELLAEENQRLREQLQLLE-EQHRAALAH 2638



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 98/393 (24%), Positives = 156/393 (39%), Gaps = 42/393 (10%)

Query: 62   SLVDALLEQVARF-REQLRR--QEGGAAEAQMRQEIERLTE--RLEEKEREMQQLLSQPQ 116
            S +  L  Q  +F  E LRR  +E   AE Q  +E ERL E     EK+R++ +  +Q +
Sbjct: 1351 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1410

Query: 117  HEREKEVVLLRRSMAEG----ERARAASDVLCRSLANETHQLRRTLTA-------TAHMC 165
             + E+E   L++ M E     E A   +    RS+  E  QLR++  A        A   
Sbjct: 1411 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1470

Query: 166  QHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225
            +     ++E     R   E +  Q    +G   +Q++  + +E     +Q     E L  
Sbjct: 1471 ERSRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRR 1528

Query: 226  KWQRYNASRDEYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAA 284
            + Q      DE  R   A++    ++  E E  R E  R  + LEE      E ++ L  
Sbjct: 1529 QVQ------DESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1581

Query: 285  SRTAR----DAALERVQ-MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339
            +   R      ALE  Q   E ++ + +  F  + A  ER+   +QE    VA L  +  
Sbjct: 1582 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAE 1638

Query: 340  WR-QDSREPDAGRIHAGSKTAKY--LAADALELMVPG---GWRPGTGSQQPEPPAEGGHP 393
             R Q   E +  R  A  +  ++   A +AL L +       +      + E   E    
Sbjct: 1639 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1698

Query: 394  GAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAE 426
             A +RG+ + Q     Q    EQ  E  R +AE
Sbjct: 1699 EARRRGKAEEQAVR--QRELAEQELEKQRQLAE 1729


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 67/280 (23%), Positives = 120/280 (42%), Gaps = 25/280 (8%)

Query: 75  REQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGE 134
           R++   +E G    Q RQE ER     EE+  + ++L  + +  R++E+   R+   E E
Sbjct: 125 RDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQERE 184

Query: 135 RARAASDVLCRSLANET------HQLRRTLTATAHMCQHLAKCLDERQHAQRNVGER--- 185
             RA  + L     +ET       QLRR       + +   K  +E+Q  +R   +R   
Sbjct: 185 ERRAEEEQLQSCKGHETEEFPDEEQLRR-----RELLELRRKGREEKQQQRRERQDRVFQ 239

Query: 186 SPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQL 245
             ++ E     T ++   EKLQEE    ++++   E+   K +R    R+        Q 
Sbjct: 240 EEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQ- 298

Query: 246 RGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILA 305
              ++  E +L RK+      Q EE+     + ++E    R  +    E+ +  EQQ+  
Sbjct: 299 ---RLRREQQLRRKQEEERREQQEERREQ--QERREQQEERREQQLRREQEERREQQLRR 353

Query: 306 YKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSR 345
            +++   ER  RE+   R QE E +   L  +   R++ +
Sbjct: 354 EQEE---ER--REQQLRREQEEERREQQLRREQQLRREQQ 388



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 75/306 (24%), Positives = 129/306 (42%), Gaps = 39/306 (12%)

Query: 69   EQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHER--------- 119
            E+V +  EQL R+E    E + RQE+ER     EE ++E +QLL + Q +R         
Sbjct: 1144 EEVQQEEEQLLREE---PEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYR 1200

Query: 120  -EKEVVLLRRSMA--------------EGERARAASD--VLCRSLANET-HQLRRTLTAT 161
             E+E+   +R                 E E+  A  D  V C+   NE   QL  +    
Sbjct: 1201 EEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRD 1260

Query: 162  AHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK-LQEENRLLKQKVTHV 220
                Q L   L E+Q   R   E+   + +  D H   +  +E+  Q+E +   +K    
Sbjct: 1261 RQSQQDLQHLLGEQQERDR---EQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEE 1317

Query: 221  EDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQ 280
            + L  + +     R E  R    + + LQ   E  L R+E  R  R  EE++    + ++
Sbjct: 1318 KQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFR--EEELRHQEQGRK 1375

Query: 281  ELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSW 340
             L   +  R    ER  + E+Q L  ++     R DR+R   + +E E++++       +
Sbjct: 1376 FLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDR---KFREEEQQLSRQERDRKF 1432

Query: 341  RQDSRE 346
            R++ ++
Sbjct: 1433 REEEQQ 1438



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 79/293 (26%), Positives = 129/293 (44%), Gaps = 45/293 (15%)

Query: 68  LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKE---VV 124
           LE+  R  +Q RR++    E + R+E +RL +R EE+ER  Q+L S+ Q  RE+E     
Sbjct: 491 LEEEERREQQERREQQLRREQEERRE-QRL-KRQEEEERLQQRLRSEQQLRREQEERREQ 548

Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDER--QHAQRNV 182
           LL+R     E  R   +   + L  E  + R            L K  +ER  Q  +R  
Sbjct: 549 LLKRE----EEKRLEQERREQRLKREQEERR----------DQLLKREEERRQQRLKREQ 594

Query: 183 GERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLH 242
            ER   + +  +        +E+L++E R  +Q++   E    + Q+   S ++  R   
Sbjct: 595 EERLEQRLKREE--------VERLEQEER-REQRLKREEPEEERRQQLLKSEEQEERRQQ 645

Query: 243 AQLRGLQIPHEPELMRKE-----ISRLNRQLEE--KINDCAEVKQELAASRTARDAALER 295
              R  Q   E  L R+E       RL R+ EE  +  + AE +QE      AR+    R
Sbjct: 646 QLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE-----QARERIKSR 700

Query: 296 VQMLEQQILAYKDDFMSE---RADRERAQSRIQELEEKVASLLHQVSWRQDSR 345
           +   + Q+ +  D   S+   R  ++  Q R QE EEK      ++ W+++ R
Sbjct: 701 IPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEER 753



 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 74/312 (23%), Positives = 129/312 (41%), Gaps = 54/312 (17%)

Query: 69  EQVARFREQLRR---------------------QEGGAAEAQMRQEIERLTE----RLEE 103
           +Q  R  +QLRR                     Q+    E Q+R+E E   E    R +E
Sbjct: 297 QQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQE 356

Query: 104 KEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAH 163
           +ER  QQL  + + ER ++ +   + +   ++ R    +          QLRR       
Sbjct: 357 EERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 416

Query: 164 MC----QHLAKCLDERQHAQRNVGER-----SPDQSEHTDGHTSVQSVIEKLQEENRLLK 214
                 Q L +  +E +H Q++  ER       +Q E  D     +   E+ ++E R  +
Sbjct: 417 QQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRD-WLKREEETERHEQERRKQQ 475

Query: 215 QKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKIND 274
            K    E+   +W +     +E  R    + R  Q+  E E  R++  RL RQ EE+   
Sbjct: 476 LKRDQEEERRERWLKL----EEEERREQQERREQQLRREQEERREQ--RLKRQEEEE--- 526

Query: 275 CAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRI-QELEEKVAS 333
              ++Q L + +  R    ER     +Q+L  +++   +R ++ER + R+ +E EE+   
Sbjct: 527 --RLQQRLRSEQQLRREQEER----REQLLKREEE---KRLEQERREQRLKREQEERRDQ 577

Query: 334 LLHQVSWRQDSR 345
           LL +   R+  R
Sbjct: 578 LLKREEERRQQR 589



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 76/341 (22%), Positives = 138/341 (40%), Gaps = 34/341 (9%)

Query: 29  QRLRRLQDQLAARDALIARLRARLAA-LEGDAAPSLVDALL-EQVARFREQLRRQEGGAA 86
           QRL+R Q++   RD L+ R   R    L+ +    L   L  E+V R  ++ RR++    
Sbjct: 565 QRLKREQEE--RRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKR 622

Query: 87  EAQMRQEIERLTERLEEKEREMQQLLSQPQHER-------EKEVVLLRRSMAEGERARAA 139
           E    +  ++L +  E++ER  QQL  + Q  R       E+E  L +R   E E  R  
Sbjct: 623 EEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERRE 682

Query: 140 SDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV 199
            ++          +++  +       +  A     + +++    E    + E  +     
Sbjct: 683 QELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRR 742

Query: 200 QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259
           +S ++  QEE R  +Q+    +  +  WQ     + E  R   +    L+   E +L  +
Sbjct: 743 ESELQ-WQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAE 801

Query: 260 EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQ-------QILAYKDDFMS 312
           E     +Q E++     E K++    R  R+  L+ ++  EQ       Q L  ++D + 
Sbjct: 802 E----RQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQ 857

Query: 313 ERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIH 353
           E  D+ER +S+ Q  ++K         WR    E    R H
Sbjct: 858 E--DQERRRSQEQRRDQK---------WRWQLEEERKRRRH 887



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 64/281 (22%), Positives = 115/281 (40%), Gaps = 46/281 (16%)

Query: 69  EQVARFREQLRRQEGGAAEAQMRQE----IERLTERLEEKEREMQQLLSQPQHEREKEVV 124
           EQ  R  +QLRR++    E Q+R+E     E+   R ++  RE ++   + +HE+E+   
Sbjct: 386 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQ 445

Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184
            L+R   E        D L R    E H+  R             + L   Q  +R    
Sbjct: 446 RLKREQEE------RRDWLKREEETERHEQERR-----------KQQLKRDQEEERRERW 488

Query: 185 RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQ 244
              ++ E  +     +  + + QEE R  +Q++   E+     QR  + +         Q
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERR--EQRLKRQEEEERLQQRLRSEQ---------Q 537

Query: 245 LRGLQIPHEPELMRKE----------ISRLNRQLEEKINDCAEVKQELAASRTARDAALE 294
           LR  Q     +L+++E            RL R+ EE+ +   + ++E    R  R    E
Sbjct: 538 LRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKR----E 593

Query: 295 RVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLL 335
           + + LEQ++   + + + +   RE+   R +  EE+   LL
Sbjct: 594 QEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLL 634



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 53/256 (20%), Positives = 110/256 (42%), Gaps = 24/256 (9%)

Query: 76   EQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGER 135
            E+ RR+    A+  +++++ +  + L+E+E E+Q+   + +  +E+E     R   E E+
Sbjct: 881  ERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQE-----RQYREEEQ 935

Query: 136  ARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG 195
             +   + L R    +  +  R         +   K    +Q  ++ +GE  P++    + 
Sbjct: 936  LQQEEEQLLREEREKRRRQERE--------RQYRKDKKLQQKEEQLLGE-EPEKRRRQER 986

Query: 196  HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPE 255
                +   E  QEE +LL+++    +    +W+R    +DE  +     LR        E
Sbjct: 987  EKKYREEEELQQEEEQLLREE--REKRRRQEWERQYRKKDELQQEEEQLLR-------EE 1037

Query: 256  LMRKEISRLNRQLEEKINDCAEVKQELAASR-TARDAALERVQMLEQQILAYKDDFMSER 314
              ++ +    RQ  E+     E +Q L   R T R   LER    E+++   ++  + E 
Sbjct: 1038 REKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREE 1097

Query: 315  ADRERAQSRIQELEEK 330
             ++ R Q R ++  E+
Sbjct: 1098 PEKRRRQERERQCREE 1113



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 61/260 (23%), Positives = 105/260 (40%), Gaps = 20/260 (7%)

Query: 76   EQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGER 135
            +QLRRQE G    Q R    R  E+L + ERE QQL  Q   ER+++  L  + +   E+
Sbjct: 1538 QQLRRQERGQQRRQDRDRKFREEEQLRQ-EREEQQLSRQ---ERDRKFRLEEQKVRRQEQ 1593

Query: 136  ARAASDVLCRSLANE-THQLR----RTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQS 190
             R   +   +    E   QLR    R       + Q   +    RQ   R   E  P   
Sbjct: 1594 ERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLR 1653

Query: 191  EHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQI 250
                          K +EE +LL++          + Q     RD   R    QLR  + 
Sbjct: 1654 RQEREQQLRHDRDRKFREEEQLLQE--------GEEQQLRRQERDRKFREEEQQLRRQE- 1704

Query: 251  PHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDF 310
              E + +++E     ++LE K  +  +++QE    +  R     ++ + E+Q+   +++ 
Sbjct: 1705 -RERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKI-LEEEQLRPEREEQ 1762

Query: 311  MSERADRERAQSRIQELEEK 330
               R +R+R     ++L ++
Sbjct: 1763 QLRRQERDRKFREEEQLRQE 1782



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 58/274 (21%), Positives = 124/274 (45%), Gaps = 39/274 (14%)

Query: 69  EQVARFRE--QLRRQEGGAAEAQMRQEIERLTERLEEKE--------REMQQLLSQPQHE 118
           E+  R RE  +LRR+     + Q R+  +R+ +  EEKE        R+ ++ L + + +
Sbjct: 207 EEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ 266

Query: 119 REKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHA 178
           R++E+        E E+ R       R    E  Q ++ L     + +   +   E+Q  
Sbjct: 267 RQREL------QEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEE 320

Query: 179 QRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYV 238
           +R   ER   Q E        +  + + QEE R  +Q++   ++   + Q+    ++E  
Sbjct: 321 RREQQERREQQEERR------EQQLRREQEERR--EQQLRREQEEERREQQLRREQEE-- 370

Query: 239 RGLHAQLRGLQIPHEPELMRKEISRLNRQL--EEKINDCAEVKQELAASRTARDAALERV 296
                + R  Q+  E +L R++  R  +QL  E+++    ++++E    +  R+  L R 
Sbjct: 371 -----ERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE---QQLRREQQLRRE 422

Query: 297 QMLEQQILAYKDDFMSERADRERAQSRIQELEEK 330
           Q L ++    +++   ++ ++ER + R++  +E+
Sbjct: 423 QQLRRE---QEEERHEQKHEQERREQRLKREQEE 453



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 69/293 (23%), Positives = 119/293 (40%), Gaps = 42/293 (14%)

Query: 69   EQVARFRE---QLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQ------HER 119
            E+  +FRE   Q+RRQE    E +  +E ++L +    K RE +QLL + +       ER
Sbjct: 1427 ERDRKFREEEQQVRRQE---RERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQER 1483

Query: 120  EKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQ 179
            +++ +   + +   ER R   +   RS   E   L        H  Q   K L E Q  +
Sbjct: 1484 DRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEE--EQQLHRQQRQRKFLQEEQQLR 1541

Query: 180  RNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVR 239
            R   ER   + +  D     +  + + +EE +L +Q+     D   + +     R E  R
Sbjct: 1542 RQ--ERGQQRRQDRDRKFREEEQLRQEREEQQLSRQE----RDRKFRLEEQKVRRQEQER 1595

Query: 240  GLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAE------------VKQELAASRT 287
                  + L+     + +R+E  R  R+ E+ + +  E            +++E    R 
Sbjct: 1596 KFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQ 1655

Query: 288  ARDAAL----ERVQMLEQQILAYKDDFMSERADRER------AQSRIQELEEK 330
             R+  L    +R    E+Q+L   ++    R +R+R       Q R QE E K
Sbjct: 1656 EREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERK 1708



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 63/285 (22%), Positives = 115/285 (40%), Gaps = 21/285 (7%)

Query: 68   LEQVARFREQLRRQEGGAAEAQMR--QEIERLTERLEEKEREMQQLLSQPQHER-----E 120
            LE+  R R Q R ++    E Q+R  +  ++L +  + K RE +Q LS+ + +R     E
Sbjct: 1377 LEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEE 1436

Query: 121  KEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQR 180
            ++V    R     E  +       R    E   L+       H  +   K L+E Q  +R
Sbjct: 1437 QQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRR 1496

Query: 181  NVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRG 240
               +R   + E        + + E+ Q   +  ++K    E    + +R    R +  R 
Sbjct: 1497 QERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRK 1556

Query: 241  LHAQLRGLQIPHEPELMRKEISRLNRQLEEKI------NDCAEVKQELAASRTARDAALE 294
               + +  Q   E +L R+E  R  R  E+K+          E +Q+L      +    E
Sbjct: 1557 FREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQE 1616

Query: 295  RVQML--EQQILAYKDDFMSERADRER------AQSRIQELEEKV 331
            R +    ++Q+L  +++    R +R+R       Q R QE E+++
Sbjct: 1617 RDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQL 1661



 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 57/264 (21%), Positives = 116/264 (43%), Gaps = 15/264 (5%)

Query: 69  EQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRR 128
           E+  R  ++   +E    E  +R+E E+L E   +++RE+Q+   Q   + E++ +   R
Sbjct: 232 ERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQ-LRKLERQELRRER 290

Query: 129 SMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDER--QHAQRNVGERS 186
              E ++ R   +   + L  +  + RR         Q   +  +ER  Q  +R   ER 
Sbjct: 291 QEEEQQQQRLRRE---QQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERR 347

Query: 187 PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246
             Q          +  + + QEE R  +Q++   + L  + Q     R++ +R      R
Sbjct: 348 EQQLRREQEEERREQQLRREQEEER-REQQLRREQQLRREQQ---LRREQQLRREQQLRR 403

Query: 247 GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAY 306
             Q+  E +L R++  R  +QL     +  E + E    +  R+  L+R Q   +  L  
Sbjct: 404 EQQLRREQQLRREQQLRREQQLR---REQEEERHEQKHEQERREQRLKREQEERRDWLKR 460

Query: 307 KDDFMSERADRERAQSRIQELEEK 330
           +++  +ER ++ER + +++  +E+
Sbjct: 461 EEE--TERHEQERRKQQLKRDQEE 482



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 84/353 (23%), Positives = 133/353 (37%), Gaps = 73/353 (20%)

Query: 26   EAGQRLRRLQDQLAARDALIARLRA--RLAALEGDAAPSLVDALL---EQVARFRE---Q 77
            E GQ+ R+ +D+    +  + + R   +L+  E D    L +  +   EQ  +F E   Q
Sbjct: 1544 ERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQ 1603

Query: 78   LRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLL------------------------- 112
            LRRQEG   + Q+RQE +R       K RE +QLL                         
Sbjct: 1604 LRRQEG---QQQLRQERDR-------KFREDEQLLQEREEQQLHRQERDRKFLEEEPQLR 1653

Query: 113  -----SQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQH 167
                  Q +H+R+++     + + EGE  +       R    E  QLRR         + 
Sbjct: 1654 RQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ--------ER 1705

Query: 168  LAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW 227
              K L E Q  +R   ER   + E     T      E+L+ + R   +K+   E L  + 
Sbjct: 1706 ERKFLQEEQQLRRQELERKFREEEQLRQETEQ----EQLRRQERY--RKILEEEQLRPER 1759

Query: 228  QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287
            +     R E  R    + +  Q   E +L  +E  R  R+ EE++    E +Q     R 
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFRE-EEQLRQEREEQQLRPQQRD 1818

Query: 288  ARDAALERVQMLEQQILAYK----------DDFMSERADRERAQSRIQELEEK 330
             +    E    LE+Q    +          + F ++   R   Q   QE E+K
Sbjct: 1819 GKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQK 1871



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 68/310 (21%), Positives = 121/310 (39%), Gaps = 45/310 (14%)

Query: 70  QVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKER-----EMQQLLSQPQHE------ 118
           ++A   EQ  +QE      + R++ E   +R E +ER     E +QL S   HE      
Sbjct: 147 ELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPD 206

Query: 119 ----REKEVVLLRRSMAE--GERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCL 172
               R +E++ LRR   E   ++ R   D + +    +  + R T+     + +   K  
Sbjct: 207 EEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETV-----LRKEEEKLQ 261

Query: 173 DERQHAQRNVGE--------------RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVT 218
           +E    QR + E              R   + E        +  + + QEE R  +++  
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER--REQQE 319

Query: 219 HVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEV 278
              +   + ++    R++ +R    + R  Q+  E E  R+E      Q EE+       
Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRR 379

Query: 279 KQELAASRTARDAALERVQML--EQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
           +Q+L      R+  L R Q L  EQQ+   +     ++  RE+   R Q+L  +     H
Sbjct: 380 EQQL-----RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERH 434

Query: 337 QVSWRQDSRE 346
           +    Q+ RE
Sbjct: 435 EQKHEQERRE 444



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 78/332 (23%), Positives = 140/332 (42%), Gaps = 41/332 (12%)

Query: 29  QRLRRLQDQLAARDALIARLRARLAALEGDAAPSLV----DALLEQVARFREQLRRQEGG 84
           QRL+R +++   +  L  R   +L   + +    L+    +  LEQ  R  ++L+R++  
Sbjct: 517 QRLKRQEEEERLQQRL--RSEQQLRREQEERREQLLKREEEKRLEQERR-EQRLKREQEE 573

Query: 85  AAEAQMRQEIERLTERLE-EKEREMQQLLSQPQHER----EKEVVLLRRSMAEGERARAA 139
             +  +++E ER  +RL+ E+E  ++Q L + + ER    E+    L+R   E ER +  
Sbjct: 574 RRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQ- 632

Query: 140 SDVLCRSLANE---THQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGH 196
              L +S   E     QLRR         Q L +  +E +  QR   E   ++ E     
Sbjct: 633 ---LLKSEEQEERRQQQLRREQQERRE--QRLKREEEEERLEQRLKREHEEERREQELAE 687

Query: 197 TSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQR-YNASRDEYVRGLHAQLRGLQIPHEPE 255
              +   E++  ++R+ K +     + +A+  + Y+  R +  +    +    +   E E
Sbjct: 688 EEQEQARERI--KSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESE 745

Query: 256 LMRKEISRLNRQL--EEKINDC-----AEVKQELAASRTA----------RDAALERVQM 298
           L  +E  R +RQ   EE+  D      AE K E    R +          R    E  Q 
Sbjct: 746 LQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQ 805

Query: 299 LEQQILAYKDDFMSERADRERAQSRIQELEEK 330
            EQ+ L  +++    R  R   +  +Q LEE+
Sbjct: 806 REQRFLPEEEEKEQRRRQRREREKELQFLEEE 837



 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 57/284 (20%), Positives = 116/284 (40%), Gaps = 49/284 (17%)

Query: 69   EQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRR 128
            EQ+ R   + RR++    + + + E+++  E+L  +ERE ++L  + +  RE+E +    
Sbjct: 1001 EQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEE 1060

Query: 129  SMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPD 188
                GE          R       Q R+                +E Q  +  +    P+
Sbjct: 1061 EQLLGEERET------RRRQELERQYRKE---------------EELQQEEEQLLREEPE 1099

Query: 189  QSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGL 248
            +    +     +   E  QEE +LL++            +R    R E  R    +    
Sbjct: 1100 KRRRQERERQCREEEELQQEEEQLLRE------------EREKRRRQELERQYREEEEVQ 1147

Query: 249  QIPHEPELMRKEISRLNRQ-LEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYK 307
            Q   E +L+R+E  +  RQ LE +  +  E++QE    +  R+   +R Q  E+Q   Y+
Sbjct: 1148 Q--EEEQLLREEPEKRRRQELERQYREEEELQQE--EEQLLREEQEKRRQERERQ---YR 1200

Query: 308  DDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGR 351
            ++   E   R++ + R ++ +++       + W+ +  + +A R
Sbjct: 1201 EE---EELQRQKRKQRYRDEDQR-----SDLKWQWEPEKENAVR 1236



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 73/305 (23%), Positives = 120/305 (39%), Gaps = 49/305 (16%)

Query: 69  EQVARFREQLRRQEGGAAEAQMRQEIERLT-----ERLEEKEREMQQLLSQPQHEREKEV 123
           E+  R   +L+ QE   A  Q ++E +R       +  E+ ER  Q+L ++P    ++E 
Sbjct: 737 EKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRE- 795

Query: 124 VLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG 183
               R +   ER +     L      E  Q RR         Q L    +E +  QR   
Sbjct: 796 ----RQLRAEERQQREQRFLPEE--EEKEQRRRQRREREKELQFL----EEEEQLQRR-- 843

Query: 184 ERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHA 243
           ER+    E  DG       +++ QE  R  +Q+     D   +WQ     R      L+A
Sbjct: 844 ERAQQLQEEEDG-------LQEDQERRRSQEQR----RDQKWRWQ-LEEERKRRRHTLYA 891

Query: 244 QLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQI 303
           +      P   E +RKE   L  + EE   +  E ++     R  R+   E++Q  E+Q+
Sbjct: 892 K------PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREE--EQLQQEEEQL 943

Query: 304 LAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLA 363
           L         R +RE+ + + +E + +    L Q   +    EP+  R     K  KY  
Sbjct: 944 L---------REEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREK--KYRE 992

Query: 364 ADALE 368
            + L+
Sbjct: 993 EEELQ 997



 Score = 36.6 bits (83), Expect = 0.045
 Identities = 58/252 (23%), Positives = 96/252 (38%), Gaps = 47/252 (18%)

Query: 73   RFREQLRRQEGGAAEAQMRQEIERL----TERLEEKEREMQQLLSQPQHEREKEVVLLRR 128
            +FRE+ +  + G  +   RQE +R      ++L  +ERE + L  + Q  R++    L R
Sbjct: 1668 KFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQE----LER 1723

Query: 129  SMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE-------------R 175
               E E+ R  +         E  QLRR         +   K L+E             R
Sbjct: 1724 KFREEEQLRQET---------EQEQLRRQ--------ERYRKILEEEQLRPEREEQQLRR 1766

Query: 176  QHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKV-----THVEDLNAKWQRY 230
            Q   R   E    + E  +     Q    K +EE +L +++          D   +W+  
Sbjct: 1767 QERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEE 1826

Query: 231  NASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARD 290
                +E  + L  Q R  Q   E +   +E S   R+ E+++    E K+     R  R+
Sbjct: 1827 QLQLEEQEQRLR-QERDRQYRAEEQFATQEKS---RREEQELWQEEEQKRRQERERKLRE 1882

Query: 291  AALERVQMLEQQ 302
              + R Q  EQ+
Sbjct: 1883 EHIRRQQKEEQR 1894



 Score = 29.3 bits (64), Expect = 7.2
 Identities = 21/80 (26%), Positives = 38/80 (47%), Gaps = 12/80 (15%)

Query: 67   LLEQVARFRE----QLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKE 122
            L EQ  R R+    Q R +E  A + + R+E + L +  E+K R+ ++   + +H     
Sbjct: 1830 LEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEH----- 1884

Query: 123  VVLLRRSMAEGERARAASDV 142
               +RR   E +R R   ++
Sbjct: 1885 ---IRRQQKEEQRHRQVGEI 1901


>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
           sapiens]
          Length = 1116

 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 87/366 (23%), Positives = 159/366 (43%), Gaps = 70/366 (19%)

Query: 10  WEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLE 69
           WEE  + AA L     E GQ    ++ +L+ +D  +  L+ +L  L    + S      +
Sbjct: 454 WEELKKKAAGLQA---EIGQ----VKQELSRKDTELLALQTKLETLTNQFSDSK-----Q 501

Query: 70  QVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQ------------- 116
            +   +E L  +E  AA  Q   E++ L  RLEEKE  + +   Q Q             
Sbjct: 502 HIEVLKESLTAKEQRAAILQT--EVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEI 559

Query: 117 HE-------REKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLA 169
           H+       +E++V +L++ +   +      +    SL      L+   T T      L 
Sbjct: 560 HDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLE 619

Query: 170 KCLDERQHA-QRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQ 228
           + L E++   +R   +R  D+ E        Q  I+  +++ + LK+KV+ ++   ++ +
Sbjct: 620 EALAEKERTIERLKEQRDRDEREK-------QEEIDNYKKDLKDLKEKVSLLQGDLSEKE 672

Query: 229 RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288
                  E+   L +   GL+   +  L   EI+     LE+K  +C +++ +L   + A
Sbjct: 673 ASLLDLKEHASSLASS--GLK--KDSRLKTLEIA-----LEQKKEECLKMESQL---KKA 720

Query: 289 RDAALE---------RVQMLEQQILAYKDDFMSERADRERAQSRIQELE-------EKVA 332
            +AALE         R+Q LE++I  YKD+    +A+ +R    ++E+E       +K+A
Sbjct: 721 HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIA 780

Query: 333 SLLHQV 338
            L  QV
Sbjct: 781 ELERQV 786



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 61/307 (19%), Positives = 133/307 (43%), Gaps = 35/307 (11%)

Query: 64  VDALLEQVAR----FREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHER 119
           +++LLEQ  +     RE++ R+   A ++   + ++ + E  + K   M++ L     + 
Sbjct: 346 LESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGL----RDL 401

Query: 120 EKEVVLLRRSMA----EGERARAASDVL---CRSLANETHQLRRTLTATAHMCQHLAKCL 172
           E+E+ +L+ + A    E E      +V     + + N+  QL+  L++     + L K  
Sbjct: 402 EEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKK-- 459

Query: 173 DERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHV-EDLNAKWQRYN 231
            +    Q  +G+   + S       ++Q+ +E L  +    KQ +  + E L AK QR  
Sbjct: 460 -KAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAA 518

Query: 232 ASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEK---------INDCAEVKQ-E 281
             + E           L++  +  ++ K+  ++    EEK         + D  +VK+ +
Sbjct: 519 ILQTE------VDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERK 572

Query: 282 LAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWR 341
           +   +   +   E+++  E+Q+ + K+   S +AD     + +  LEE +A     +   
Sbjct: 573 VNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERL 632

Query: 342 QDSREPD 348
           ++ R+ D
Sbjct: 633 KEQRDRD 639



 Score = 30.0 bits (66), Expect = 4.2
 Identities = 52/245 (21%), Positives = 96/245 (39%), Gaps = 28/245 (11%)

Query: 25   HEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84
            ++  +++  L+ Q+  ++  +A L+ +    +  +A  L +A      R RE        
Sbjct: 773  NDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEA------RRREDNLNDSSQ 826

Query: 85   AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVL- 143
              +  +R++ +R+ E LEE  RE  Q+ +      E+E+VL +   A     +   ++L 
Sbjct: 827  QLQDSLRKKDDRI-EELEEALRESVQITA------EREMVLAQEESARTNAEKQVEELLM 879

Query: 144  -CRSLANETHQLRRTLTAT----AHMCQHLAKCLDERQHAQRNVGERSPD-------QSE 191
                +  E   ++  L++T    A    HL     ER+     V E   +       + +
Sbjct: 880  AMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKD 939

Query: 192  HTDGHTSVQSVIEKLQEENRLLK-QKVTHVEDLNAKWQ-RYNASRDEYVRGLHAQLRGLQ 249
                   + S  +K QEE   LK +K   V+ L  + Q R     D Y           Q
Sbjct: 940  ANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQ 999

Query: 250  IPHEP 254
              H+P
Sbjct: 1000 TNHKP 1004


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 88/386 (22%), Positives = 158/386 (40%), Gaps = 47/386 (12%)

Query: 2    SRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAP 61
            S+D       E  ++  AL T   E   +L  L+D+L A +    RL   + AL+G    
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578

Query: 62   SLVDALLEQVARFREQLRRQEGGAAEAQMRQEIER--------LTERLEEKEREMQQLLS 113
             L  A  EQ    R QL+RQ     E +   E ER          ++LE   ++++    
Sbjct: 1579 DL-QARDEQNEEKRRQLQRQ---LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1634

Query: 114  QPQHEREKEVVLLRRSMA-------EGERARAASDVLCRSLANETHQLRRTLTATAHMCQ 166
                 RE+ +  LR+  A       E E ARA+ D +  + A E  +  ++L A     Q
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF-ATAKENEKKAKSLEADLMQLQ 1693

Query: 167  H-LAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225
              LA     R+ A     E + + +    G  +       LQ+E R L+ ++  +E+   
Sbjct: 1694 EDLAAAERARKQADLEKEELAEELASSLSGRNA-------LQDEKRRLEARIAQLEEELE 1746

Query: 226  KWQRYNASRDEYVRGLHAQLRGL--------QIPHEPELMRKEISRLNRQLEEKINDC-A 276
            + Q    +  + VR    Q   L            + E  R+++ R N++L  K+++   
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1806

Query: 277  EVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
             VK +  ++  A +A   ++  LE+Q+         E  +++ A   +++ ++K+  +L 
Sbjct: 1807 AVKSKFKSTIAALEA---KIAQLEEQV-------EQEAREKQAATKSLKQKDKKLKEILL 1856

Query: 337  QVSWRQDSREPDAGRIHAGSKTAKYL 362
            QV   +   E    +   G+   K L
Sbjct: 1857 QVEDERKMAEQYKEQAEKGNARVKQL 1882



 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 72/362 (19%), Positives = 153/362 (42%), Gaps = 39/362 (10%)

Query: 11   EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPS-------- 62
            +E  R    + T   +  +    LQDQL         L   ++ L    + S        
Sbjct: 1325 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1384

Query: 63   -LVDALLEQVARFREQLRR-----QEGGAA-------EAQMRQEIE----------RLTE 99
              V+AL E   RF++++       +E  AA       + +++QE++          +L  
Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444

Query: 100  RLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLT 159
             LE+K+R+  QLL++ ++   K      R+ AE       +  L R+L  E  + +  L 
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL-EEALEAKEELE 1503

Query: 160  ATAHMCQ-HLAKCLDERQHAQRNVGERSPD----QSEHTDGHTSVQSVIEKLQEENRLLK 214
             T  M +  +   +  +    +NV E        +++  +  T ++ + ++LQ       
Sbjct: 1504 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1563

Query: 215  QKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPEL--MRKEISRLNRQLEEKI 272
            +   +++ L  +++R   +RDE       QL+     +E EL   RK+ +      ++  
Sbjct: 1564 RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1623

Query: 273  NDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVA 332
             D  +++ +  ++   R+ A+++++ L+ Q+  ++ +    RA R+   +  +E E+K  
Sbjct: 1624 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1683

Query: 333  SL 334
            SL
Sbjct: 1684 SL 1685



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 65/266 (24%), Positives = 122/266 (45%), Gaps = 24/266 (9%)

Query: 85   AAEAQMRQEI-ERLTERLEEKEREMQQLLSQPQHEREK---EVVLLRRSMAEGERARAAS 140
            AA+ Q  +EI   +  RLEE+E   QQL    Q ER+K   +++ L   + E E AR   
Sbjct: 914  AAKKQELEEILHEMEARLEEEEDRGQQL----QAERKKMAQQMLDLEEQLEEEEAAR--- 966

Query: 141  DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQ 200
                     +  QL + +TA A + +   + L       +   ER   +   +D  T++ 
Sbjct: 967  ---------QKLQLEK-VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1016

Query: 201  SVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPEL--MR 258
               EK +   +L  +  + + +L  + ++   SR E +  L  +L G       ++  ++
Sbjct: 1017 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKLEGDASDFHEQIADLQ 1075

Query: 259  KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRE 318
             +I+ L  QL +K  +       L      ++ AL++++ LE  I   ++D  SERA R 
Sbjct: 1076 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1135

Query: 319  RAQSRIQELEEKVASLLHQVSWRQDS 344
            +A+ + ++L E++ +L  ++    DS
Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTLDS 1161



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 75/356 (21%), Positives = 148/356 (41%), Gaps = 61/356 (17%)

Query: 31   LRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG------ 84
            L RL D++A ++  + ++R     LEG  +    D   E+ AR + + ++++ G      
Sbjct: 1096 LARLDDEIAQKNNALKKIRE----LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1151

Query: 85   -----------AAEAQMR----QEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRS 129
                       A + ++R    QE+  L + L+E+ R  +  + + + +  + V  L   
Sbjct: 1152 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1211

Query: 130  MAEGERARAASDVLCRSLANETHQLR---RTLTATAHMCQHLAKCLDER-QHAQRNVGER 185
            + + +RA+A  D   ++L  E   L    R L       +H  K L+ + Q  Q    + 
Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271

Query: 186  SPDQSEHTDGHTSVQSVIE--------------KLQEENRLLKQKVTHVEDLNAKWQRYN 231
               ++E  D    +Q+ +E              KL ++   L  ++   ++L  +  R  
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331

Query: 232  ASRDEYVRGLHAQLRGLQIPHEPEL-----MRKEISRLNRQL---EEKINDCAEVKQELA 283
             +    +R L  +   LQ   + E+     + + IS LN QL   ++K+ D A   + L 
Sbjct: 1332 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1391

Query: 284  ASRTARDAALERV-QMLEQQILAYKDDFMSERADRERAQSRI-QELEEKVASLLHQ 337
              +      +E + Q  E++  AY           E+ ++R+ QEL++ V  L +Q
Sbjct: 1392 EGKKRFQKEIENLTQQYEEKAAAYD--------KLEKTKNRLQQELDDLVVDLDNQ 1439



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 56/276 (20%), Positives = 110/276 (39%), Gaps = 45/276 (16%)

Query: 32   RRLQDQLAARDALIARLRA---RLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEA 88
            R L+D  A+RD + A  +    +  +LE D      D    + AR +  L ++E     A
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718

Query: 89   --------------QMRQEIERLTERLEEKEREMQQL------LSQPQHEREKEVVLLRR 128
                          ++   I +L E LEE++  M+ +       +Q   +   E+   R 
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778

Query: 129  SMAEGERARAASDVLCRSLANETHQL--------RRTLTATAHMCQHLAKCLD----ERQ 176
            +  + E AR   +   + L ++ H++        + T+ A       L + ++    E+Q
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838

Query: 177  HAQRNVGERSPDQSEHT----DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNA 232
             A +++ ++     E      D     +   E+ ++ N  +KQ    +E+   + QR NA
Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898

Query: 233  SRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQL 268
            +R +  R L       +     E M +E++ L  +L
Sbjct: 1899 NRRKLQRELD------EATESNEAMGREVNALKSKL 1928



 Score = 29.6 bits (65), Expect = 5.5
 Identities = 17/77 (22%), Positives = 39/77 (50%)

Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRI 352
           L +V   E+++ A +D+    +  +++A++ ++ELE+K + L  + +  Q+  + +    
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903

Query: 353 HAGSKTAKYLAADALEL 369
               +    LAA   EL
Sbjct: 904 AEAEEMRVRLAAKKQEL 920


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 88/386 (22%), Positives = 158/386 (40%), Gaps = 47/386 (12%)

Query: 2    SRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAP 61
            S+D       E  ++  AL T   E   +L  L+D+L A +    RL   + AL+G    
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585

Query: 62   SLVDALLEQVARFREQLRRQEGGAAEAQMRQEIER--------LTERLEEKEREMQQLLS 113
             L  A  EQ    R QL+RQ     E +   E ER          ++LE   ++++    
Sbjct: 1586 DL-QARDEQNEEKRRQLQRQ---LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1641

Query: 114  QPQHEREKEVVLLRRSMA-------EGERARAASDVLCRSLANETHQLRRTLTATAHMCQ 166
                 RE+ +  LR+  A       E E ARA+ D +  + A E  +  ++L A     Q
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF-ATAKENEKKAKSLEADLMQLQ 1700

Query: 167  H-LAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225
              LA     R+ A     E + + +    G  +       LQ+E R L+ ++  +E+   
Sbjct: 1701 EDLAAAERARKQADLEKEELAEELASSLSGRNA-------LQDEKRRLEARIAQLEEELE 1753

Query: 226  KWQRYNASRDEYVRGLHAQLRGL--------QIPHEPELMRKEISRLNRQLEEKINDC-A 276
            + Q    +  + VR    Q   L            + E  R+++ R N++L  K+++   
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1813

Query: 277  EVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
             VK +  ++  A +A   ++  LE+Q+         E  +++ A   +++ ++K+  +L 
Sbjct: 1814 AVKSKFKSTIAALEA---KIAQLEEQV-------EQEAREKQAATKSLKQKDKKLKEILL 1863

Query: 337  QVSWRQDSREPDAGRIHAGSKTAKYL 362
            QV   +   E    +   G+   K L
Sbjct: 1864 QVEDERKMAEQYKEQAEKGNARVKQL 1889



 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 72/362 (19%), Positives = 153/362 (42%), Gaps = 39/362 (10%)

Query: 11   EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPS-------- 62
            +E  R    + T   +  +    LQDQL         L   ++ L    + S        
Sbjct: 1332 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391

Query: 63   -LVDALLEQVARFREQLRR-----QEGGAA-------EAQMRQEIE----------RLTE 99
              V+AL E   RF++++       +E  AA       + +++QE++          +L  
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451

Query: 100  RLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLT 159
             LE+K+R+  QLL++ ++   K      R+ AE       +  L R+L  E  + +  L 
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL-EEALEAKEELE 1510

Query: 160  ATAHMCQ-HLAKCLDERQHAQRNVGERSPD----QSEHTDGHTSVQSVIEKLQEENRLLK 214
             T  M +  +   +  +    +NV E        +++  +  T ++ + ++LQ       
Sbjct: 1511 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1570

Query: 215  QKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPEL--MRKEISRLNRQLEEKI 272
            +   +++ L  +++R   +RDE       QL+     +E EL   RK+ +      ++  
Sbjct: 1571 RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1630

Query: 273  NDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVA 332
             D  +++ +  ++   R+ A+++++ L+ Q+  ++ +    RA R+   +  +E E+K  
Sbjct: 1631 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1690

Query: 333  SL 334
            SL
Sbjct: 1691 SL 1692



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 65/266 (24%), Positives = 122/266 (45%), Gaps = 24/266 (9%)

Query: 85   AAEAQMRQEI-ERLTERLEEKEREMQQLLSQPQHEREK---EVVLLRRSMAEGERARAAS 140
            AA+ Q  +EI   +  RLEE+E   QQL    Q ER+K   +++ L   + E E AR   
Sbjct: 921  AAKKQELEEILHEMEARLEEEEDRGQQL----QAERKKMAQQMLDLEEQLEEEEAAR--- 973

Query: 141  DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQ 200
                     +  QL + +TA A + +   + L       +   ER   +   +D  T++ 
Sbjct: 974  ---------QKLQLEK-VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1023

Query: 201  SVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPEL--MR 258
               EK +   +L  +  + + +L  + ++   SR E +  L  +L G       ++  ++
Sbjct: 1024 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKLEGDASDFHEQIADLQ 1082

Query: 259  KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRE 318
             +I+ L  QL +K  +       L      ++ AL++++ LE  I   ++D  SERA R 
Sbjct: 1083 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1142

Query: 319  RAQSRIQELEEKVASLLHQVSWRQDS 344
            +A+ + ++L E++ +L  ++    DS
Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTLDS 1168



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 75/356 (21%), Positives = 148/356 (41%), Gaps = 61/356 (17%)

Query: 31   LRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG------ 84
            L RL D++A ++  + ++R     LEG  +    D   E+ AR + + ++++ G      
Sbjct: 1103 LARLDDEIAQKNNALKKIRE----LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1158

Query: 85   -----------AAEAQMR----QEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRS 129
                       A + ++R    QE+  L + L+E+ R  +  + + + +  + V  L   
Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218

Query: 130  MAEGERARAASDVLCRSLANETHQLR---RTLTATAHMCQHLAKCLDER-QHAQRNVGER 185
            + + +RA+A  D   ++L  E   L    R L       +H  K L+ + Q  Q    + 
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278

Query: 186  SPDQSEHTDGHTSVQSVIE--------------KLQEENRLLKQKVTHVEDLNAKWQRYN 231
               ++E  D    +Q+ +E              KL ++   L  ++   ++L  +  R  
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338

Query: 232  ASRDEYVRGLHAQLRGLQIPHEPEL-----MRKEISRLNRQL---EEKINDCAEVKQELA 283
             +    +R L  +   LQ   + E+     + + IS LN QL   ++K+ D A   + L 
Sbjct: 1339 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1398

Query: 284  ASRTARDAALERV-QMLEQQILAYKDDFMSERADRERAQSRI-QELEEKVASLLHQ 337
              +      +E + Q  E++  AY           E+ ++R+ QEL++ V  L +Q
Sbjct: 1399 EGKKRFQKEIENLTQQYEEKAAAYD--------KLEKTKNRLQQELDDLVVDLDNQ 1446



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 56/276 (20%), Positives = 110/276 (39%), Gaps = 45/276 (16%)

Query: 32   RRLQDQLAARDALIARLRA---RLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEA 88
            R L+D  A+RD + A  +    +  +LE D      D    + AR +  L ++E     A
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725

Query: 89   --------------QMRQEIERLTERLEEKEREMQQL------LSQPQHEREKEVVLLRR 128
                          ++   I +L E LEE++  M+ +       +Q   +   E+   R 
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785

Query: 129  SMAEGERARAASDVLCRSLANETHQL--------RRTLTATAHMCQHLAKCLD----ERQ 176
            +  + E AR   +   + L ++ H++        + T+ A       L + ++    E+Q
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845

Query: 177  HAQRNVGERSPDQSEHT----DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNA 232
             A +++ ++     E      D     +   E+ ++ N  +KQ    +E+   + QR NA
Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905

Query: 233  SRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQL 268
            +R +  R L       +     E M +E++ L  +L
Sbjct: 1906 NRRKLQRELD------EATESNEAMGREVNALKSKL 1935



 Score = 29.6 bits (65), Expect = 5.5
 Identities = 17/77 (22%), Positives = 39/77 (50%)

Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRI 352
           L +V   E+++ A +D+    +  +++A++ ++ELE+K + L  + +  Q+  + +    
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910

Query: 353 HAGSKTAKYLAADALEL 369
               +    LAA   EL
Sbjct: 911 AEAEEMRVRLAAKKQEL 927


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 88/386 (22%), Positives = 158/386 (40%), Gaps = 47/386 (12%)

Query: 2    SRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAP 61
            S+D       E  ++  AL T   E   +L  L+D+L A +    RL   + AL+G    
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585

Query: 62   SLVDALLEQVARFREQLRRQEGGAAEAQMRQEIER--------LTERLEEKEREMQQLLS 113
             L  A  EQ    R QL+RQ     E +   E ER          ++LE   ++++    
Sbjct: 1586 DL-QARDEQNEEKRRQLQRQ---LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1641

Query: 114  QPQHEREKEVVLLRRSMA-------EGERARAASDVLCRSLANETHQLRRTLTATAHMCQ 166
                 RE+ +  LR+  A       E E ARA+ D +  + A E  +  ++L A     Q
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF-ATAKENEKKAKSLEADLMQLQ 1700

Query: 167  H-LAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225
              LA     R+ A     E + + +    G  +       LQ+E R L+ ++  +E+   
Sbjct: 1701 EDLAAAERARKQADLEKEELAEELASSLSGRNA-------LQDEKRRLEARIAQLEEELE 1753

Query: 226  KWQRYNASRDEYVRGLHAQLRGL--------QIPHEPELMRKEISRLNRQLEEKINDC-A 276
            + Q    +  + VR    Q   L            + E  R+++ R N++L  K+++   
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1813

Query: 277  EVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
             VK +  ++  A +A   ++  LE+Q+         E  +++ A   +++ ++K+  +L 
Sbjct: 1814 AVKSKFKSTIAALEA---KIAQLEEQV-------EQEAREKQAATKSLKQKDKKLKEILL 1863

Query: 337  QVSWRQDSREPDAGRIHAGSKTAKYL 362
            QV   +   E    +   G+   K L
Sbjct: 1864 QVEDERKMAEQYKEQAEKGNARVKQL 1889



 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 72/362 (19%), Positives = 153/362 (42%), Gaps = 39/362 (10%)

Query: 11   EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPS-------- 62
            +E  R    + T   +  +    LQDQL         L   ++ L    + S        
Sbjct: 1332 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391

Query: 63   -LVDALLEQVARFREQLRR-----QEGGAA-------EAQMRQEIE----------RLTE 99
              V+AL E   RF++++       +E  AA       + +++QE++          +L  
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451

Query: 100  RLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLT 159
             LE+K+R+  QLL++ ++   K      R+ AE       +  L R+L  E  + +  L 
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL-EEALEAKEELE 1510

Query: 160  ATAHMCQ-HLAKCLDERQHAQRNVGERSPD----QSEHTDGHTSVQSVIEKLQEENRLLK 214
             T  M +  +   +  +    +NV E        +++  +  T ++ + ++LQ       
Sbjct: 1511 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1570

Query: 215  QKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPEL--MRKEISRLNRQLEEKI 272
            +   +++ L  +++R   +RDE       QL+     +E EL   RK+ +      ++  
Sbjct: 1571 RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1630

Query: 273  NDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVA 332
             D  +++ +  ++   R+ A+++++ L+ Q+  ++ +    RA R+   +  +E E+K  
Sbjct: 1631 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1690

Query: 333  SL 334
            SL
Sbjct: 1691 SL 1692



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 65/266 (24%), Positives = 122/266 (45%), Gaps = 24/266 (9%)

Query: 85   AAEAQMRQEI-ERLTERLEEKEREMQQLLSQPQHEREK---EVVLLRRSMAEGERARAAS 140
            AA+ Q  +EI   +  RLEE+E   QQL    Q ER+K   +++ L   + E E AR   
Sbjct: 921  AAKKQELEEILHEMEARLEEEEDRGQQL----QAERKKMAQQMLDLEEQLEEEEAAR--- 973

Query: 141  DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQ 200
                     +  QL + +TA A + +   + L       +   ER   +   +D  T++ 
Sbjct: 974  ---------QKLQLEK-VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1023

Query: 201  SVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPEL--MR 258
               EK +   +L  +  + + +L  + ++   SR E +  L  +L G       ++  ++
Sbjct: 1024 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKLEGDASDFHEQIADLQ 1082

Query: 259  KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRE 318
             +I+ L  QL +K  +       L      ++ AL++++ LE  I   ++D  SERA R 
Sbjct: 1083 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1142

Query: 319  RAQSRIQELEEKVASLLHQVSWRQDS 344
            +A+ + ++L E++ +L  ++    DS
Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTLDS 1168



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 75/356 (21%), Positives = 148/356 (41%), Gaps = 61/356 (17%)

Query: 31   LRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG------ 84
            L RL D++A ++  + ++R     LEG  +    D   E+ AR + + ++++ G      
Sbjct: 1103 LARLDDEIAQKNNALKKIRE----LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1158

Query: 85   -----------AAEAQMR----QEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRS 129
                       A + ++R    QE+  L + L+E+ R  +  + + + +  + V  L   
Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218

Query: 130  MAEGERARAASDVLCRSLANETHQLR---RTLTATAHMCQHLAKCLDER-QHAQRNVGER 185
            + + +RA+A  D   ++L  E   L    R L       +H  K L+ + Q  Q    + 
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278

Query: 186  SPDQSEHTDGHTSVQSVIE--------------KLQEENRLLKQKVTHVEDLNAKWQRYN 231
               ++E  D    +Q+ +E              KL ++   L  ++   ++L  +  R  
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338

Query: 232  ASRDEYVRGLHAQLRGLQIPHEPEL-----MRKEISRLNRQL---EEKINDCAEVKQELA 283
             +    +R L  +   LQ   + E+     + + IS LN QL   ++K+ D A   + L 
Sbjct: 1339 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1398

Query: 284  ASRTARDAALERV-QMLEQQILAYKDDFMSERADRERAQSRI-QELEEKVASLLHQ 337
              +      +E + Q  E++  AY           E+ ++R+ QEL++ V  L +Q
Sbjct: 1399 EGKKRFQKEIENLTQQYEEKAAAYD--------KLEKTKNRLQQELDDLVVDLDNQ 1446



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 56/276 (20%), Positives = 110/276 (39%), Gaps = 45/276 (16%)

Query: 32   RRLQDQLAARDALIARLRA---RLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEA 88
            R L+D  A+RD + A  +    +  +LE D      D    + AR +  L ++E     A
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725

Query: 89   --------------QMRQEIERLTERLEEKEREMQQL------LSQPQHEREKEVVLLRR 128
                          ++   I +L E LEE++  M+ +       +Q   +   E+   R 
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785

Query: 129  SMAEGERARAASDVLCRSLANETHQL--------RRTLTATAHMCQHLAKCLD----ERQ 176
            +  + E AR   +   + L ++ H++        + T+ A       L + ++    E+Q
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845

Query: 177  HAQRNVGERSPDQSEHT----DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNA 232
             A +++ ++     E      D     +   E+ ++ N  +KQ    +E+   + QR NA
Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905

Query: 233  SRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQL 268
            +R +  R L       +     E M +E++ L  +L
Sbjct: 1906 NRRKLQRELD------EATESNEAMGREVNALKSKL 1935



 Score = 29.6 bits (65), Expect = 5.5
 Identities = 17/77 (22%), Positives = 39/77 (50%)

Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRI 352
           L +V   E+++ A +D+    +  +++A++ ++ELE+K + L  + +  Q+  + +    
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910

Query: 353 HAGSKTAKYLAADALEL 369
               +    LAA   EL
Sbjct: 911 AEAEEMRVRLAAKKQEL 927


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 88/386 (22%), Positives = 158/386 (40%), Gaps = 47/386 (12%)

Query: 2    SRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAP 61
            S+D       E  ++  AL T   E   +L  L+D+L A +    RL   + AL+G    
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578

Query: 62   SLVDALLEQVARFREQLRRQEGGAAEAQMRQEIER--------LTERLEEKEREMQQLLS 113
             L  A  EQ    R QL+RQ     E +   E ER          ++LE   ++++    
Sbjct: 1579 DL-QARDEQNEEKRRQLQRQ---LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1634

Query: 114  QPQHEREKEVVLLRRSMA-------EGERARAASDVLCRSLANETHQLRRTLTATAHMCQ 166
                 RE+ +  LR+  A       E E ARA+ D +  + A E  +  ++L A     Q
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF-ATAKENEKKAKSLEADLMQLQ 1693

Query: 167  H-LAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225
              LA     R+ A     E + + +    G  +       LQ+E R L+ ++  +E+   
Sbjct: 1694 EDLAAAERARKQADLEKEELAEELASSLSGRNA-------LQDEKRRLEARIAQLEEELE 1746

Query: 226  KWQRYNASRDEYVRGLHAQLRGL--------QIPHEPELMRKEISRLNRQLEEKINDC-A 276
            + Q    +  + VR    Q   L            + E  R+++ R N++L  K+++   
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1806

Query: 277  EVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
             VK +  ++  A +A   ++  LE+Q+         E  +++ A   +++ ++K+  +L 
Sbjct: 1807 AVKSKFKSTIAALEA---KIAQLEEQV-------EQEAREKQAATKSLKQKDKKLKEILL 1856

Query: 337  QVSWRQDSREPDAGRIHAGSKTAKYL 362
            QV   +   E    +   G+   K L
Sbjct: 1857 QVEDERKMAEQYKEQAEKGNARVKQL 1882



 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 72/362 (19%), Positives = 153/362 (42%), Gaps = 39/362 (10%)

Query: 11   EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPS-------- 62
            +E  R    + T   +  +    LQDQL         L   ++ L    + S        
Sbjct: 1325 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1384

Query: 63   -LVDALLEQVARFREQLRR-----QEGGAA-------EAQMRQEIE----------RLTE 99
              V+AL E   RF++++       +E  AA       + +++QE++          +L  
Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444

Query: 100  RLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLT 159
             LE+K+R+  QLL++ ++   K      R+ AE       +  L R+L  E  + +  L 
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL-EEALEAKEELE 1503

Query: 160  ATAHMCQ-HLAKCLDERQHAQRNVGERSPD----QSEHTDGHTSVQSVIEKLQEENRLLK 214
             T  M +  +   +  +    +NV E        +++  +  T ++ + ++LQ       
Sbjct: 1504 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1563

Query: 215  QKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPEL--MRKEISRLNRQLEEKI 272
            +   +++ L  +++R   +RDE       QL+     +E EL   RK+ +      ++  
Sbjct: 1564 RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1623

Query: 273  NDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVA 332
             D  +++ +  ++   R+ A+++++ L+ Q+  ++ +    RA R+   +  +E E+K  
Sbjct: 1624 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1683

Query: 333  SL 334
            SL
Sbjct: 1684 SL 1685



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 65/266 (24%), Positives = 122/266 (45%), Gaps = 24/266 (9%)

Query: 85   AAEAQMRQEI-ERLTERLEEKEREMQQLLSQPQHEREK---EVVLLRRSMAEGERARAAS 140
            AA+ Q  +EI   +  RLEE+E   QQL    Q ER+K   +++ L   + E E AR   
Sbjct: 914  AAKKQELEEILHEMEARLEEEEDRGQQL----QAERKKMAQQMLDLEEQLEEEEAAR--- 966

Query: 141  DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQ 200
                     +  QL + +TA A + +   + L       +   ER   +   +D  T++ 
Sbjct: 967  ---------QKLQLEK-VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1016

Query: 201  SVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPEL--MR 258
               EK +   +L  +  + + +L  + ++   SR E +  L  +L G       ++  ++
Sbjct: 1017 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKLEGDASDFHEQIADLQ 1075

Query: 259  KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRE 318
             +I+ L  QL +K  +       L      ++ AL++++ LE  I   ++D  SERA R 
Sbjct: 1076 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1135

Query: 319  RAQSRIQELEEKVASLLHQVSWRQDS 344
            +A+ + ++L E++ +L  ++    DS
Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTLDS 1161



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 75/356 (21%), Positives = 148/356 (41%), Gaps = 61/356 (17%)

Query: 31   LRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG------ 84
            L RL D++A ++  + ++R     LEG  +    D   E+ AR + + ++++ G      
Sbjct: 1096 LARLDDEIAQKNNALKKIRE----LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1151

Query: 85   -----------AAEAQMR----QEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRS 129
                       A + ++R    QE+  L + L+E+ R  +  + + + +  + V  L   
Sbjct: 1152 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1211

Query: 130  MAEGERARAASDVLCRSLANETHQLR---RTLTATAHMCQHLAKCLDER-QHAQRNVGER 185
            + + +RA+A  D   ++L  E   L    R L       +H  K L+ + Q  Q    + 
Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271

Query: 186  SPDQSEHTDGHTSVQSVIE--------------KLQEENRLLKQKVTHVEDLNAKWQRYN 231
               ++E  D    +Q+ +E              KL ++   L  ++   ++L  +  R  
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331

Query: 232  ASRDEYVRGLHAQLRGLQIPHEPEL-----MRKEISRLNRQL---EEKINDCAEVKQELA 283
             +    +R L  +   LQ   + E+     + + IS LN QL   ++K+ D A   + L 
Sbjct: 1332 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1391

Query: 284  ASRTARDAALERV-QMLEQQILAYKDDFMSERADRERAQSRI-QELEEKVASLLHQ 337
              +      +E + Q  E++  AY           E+ ++R+ QEL++ V  L +Q
Sbjct: 1392 EGKKRFQKEIENLTQQYEEKAAAYD--------KLEKTKNRLQQELDDLVVDLDNQ 1439



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 56/276 (20%), Positives = 110/276 (39%), Gaps = 45/276 (16%)

Query: 32   RRLQDQLAARDALIARLRA---RLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEA 88
            R L+D  A+RD + A  +    +  +LE D      D    + AR +  L ++E     A
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718

Query: 89   --------------QMRQEIERLTERLEEKEREMQQL------LSQPQHEREKEVVLLRR 128
                          ++   I +L E LEE++  M+ +       +Q   +   E+   R 
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778

Query: 129  SMAEGERARAASDVLCRSLANETHQL--------RRTLTATAHMCQHLAKCLD----ERQ 176
            +  + E AR   +   + L ++ H++        + T+ A       L + ++    E+Q
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838

Query: 177  HAQRNVGERSPDQSEHT----DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNA 232
             A +++ ++     E      D     +   E+ ++ N  +KQ    +E+   + QR NA
Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898

Query: 233  SRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQL 268
            +R +  R L       +     E M +E++ L  +L
Sbjct: 1899 NRRKLQRELD------EATESNEAMGREVNALKSKL 1928



 Score = 29.6 bits (65), Expect = 5.5
 Identities = 17/77 (22%), Positives = 39/77 (50%)

Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRI 352
           L +V   E+++ A +D+    +  +++A++ ++ELE+K + L  + +  Q+  + +    
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903

Query: 353 HAGSKTAKYLAADALEL 369
               +    LAA   EL
Sbjct: 904 AEAEEMRVRLAAKKQEL 920


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 71/329 (21%), Positives = 149/329 (45%), Gaps = 34/329 (10%)

Query: 23   LYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSL-----VDALLEQVARFREQ 77
            L  E  ++L+   ++L  R   +A+L+ ++  L+GD A +       +  + Q+      
Sbjct: 826  LLQEENEKLQGRSEELERR---VAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVH 882

Query: 78   LRRQEGGAAEAQ--MRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLR-RSMAEGE 134
             R++E  A  A+  +  E+E     L +  +E +QL  + + E E++  L R ++  E E
Sbjct: 883  ARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENE 942

Query: 135  RARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE-RQHAQRNVGERSPDQSEHT 193
            R       L +++     ++   + A+      L   LDE ++  +R + E      E T
Sbjct: 943  RWH-----LGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKT 997

Query: 194  DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRG---LHAQLRGLQI 250
                  +    K+Q+E RL+++++          + Y  ++DE +     L   L+ L+ 
Sbjct: 998  LEAEKSRLTAMKMQDEMRLMEEEL----------RDYQRAQDEALTKRQLLEQTLKDLEY 1047

Query: 251  PHEPEL-MRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDD 309
              E +  ++ + SRL +Q+E+K++   +++ EL   R   D   ER+    +Q+   +++
Sbjct: 1048 ELEAKSHLKDDRSRLVKQMEDKVS---QLEMELEEERNNSDLLSERISRSREQMEQLRNE 1104

Query: 310  FMSERADRERAQSRIQELEEKVASLLHQV 338
             + ERA R+  +     LE +   L  ++
Sbjct: 1105 LLQERAARQDLECDKISLERQNKDLKSRI 1133



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 82/389 (21%), Positives = 168/389 (43%), Gaps = 52/389 (13%)

Query: 23   LYHEAGQRLRRLQDQLAARDALIARLRAR---LAALEGDAAPSLVDALLEQVARFREQLR 79
            L  E  Q  + LQD L A++     LR R   L AL+G        AL E+V+   +++ 
Sbjct: 728  LIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKG--------ALKEEVSSHDQEMD 779

Query: 80   R-QEGGAAEAQ-MRQEIERLTERLE------------EKEREMQQLLSQPQHER------ 119
            + +E   AE Q +R+ +E  T+ +E            +   EM+  L Q ++E+      
Sbjct: 780  KLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSE 839

Query: 120  --EKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCL----D 173
              E+ V  L+R + + +   A +    +    E  QL   L       +          +
Sbjct: 840  ELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALEN 899

Query: 174  ERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNAS 233
            E + AQ N+ + + +Q + ++         E+L+     ++ +  H+     K Q+  A 
Sbjct: 900  ELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMAD 959

Query: 234  RDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAE--------------VK 279
              E  R    +L+  Q+    E  R+E++ + RQL+EK  +  +              ++
Sbjct: 960  IVEASRTSTLELQN-QLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLME 1018

Query: 280  QELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339
            +EL   + A+D AL + Q+LEQ +   + +  ++   ++     ++++E+KV+ L  ++ 
Sbjct: 1019 EELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELE 1078

Query: 340  WRQDSREPDAGRIHAGSKTAKYLAADALE 368
              +++ +  + RI    +  + L  + L+
Sbjct: 1079 EERNNSDLLSERISRSREQMEQLRNELLQ 1107



 Score = 32.7 bits (73), Expect = 0.65
 Identities = 62/295 (21%), Positives = 113/295 (38%), Gaps = 39/295 (13%)

Query: 69  EQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQP-----QHEREKEV 123
           + V R   +L+    GA+ A  R     +  ++ E E   +  + +      Q ++E+EV
Sbjct: 438 QSVGRTFAKLQGAAHGASCAHSRPPQPNIDGKVLETEGSQESTVIRAPSLGAQSKKEEEV 497

Query: 124 VLLRRSMAEGERARAAS-DVLCRSLANETHQLRRTLTATAHMC---QHLAKCLDE---RQ 176
                ++    RA A S D   + ++ +T        AT  +    Q L +  +E   +Q
Sbjct: 498 KTATATLMLQNRATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQ 557

Query: 177 HAQRNVGERSPDQSEHTDGHTSVQSVIEKLQ----------EENRLLKQKVTHVEDLNAK 226
                + E S D  + T     V  V EK+Q          + N       + V+DL  +
Sbjct: 558 ILYNYLKEGSTDNDDATK--RKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQ 615

Query: 227 WQRYNASRDEYVRGLHAQLRGLQ-IPHEPELMR--------------KEISRLNRQLEEK 271
             +      E  R L  +++  Q I  E E MR              +E S L ++LEE 
Sbjct: 616 KSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEES 675

Query: 272 INDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326
             +  +  +EL   +  R+     ++ L+ Q+    D+  S +   +R +  + E
Sbjct: 676 EGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIE 730



 Score = 30.0 bits (66), Expect = 4.2
 Identities = 34/141 (24%), Positives = 62/141 (43%), Gaps = 24/141 (17%)

Query: 89   QMRQEIERLTERLEEKEREMQQL-LSQPQHERE-KEVVLLRRSMAEGERARAASDVLCRS 146
            QM   I  L +RLE +ER+   L LS  + ER+ KE+V+      + E           S
Sbjct: 1150 QMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVM----QVDDEHL---------S 1196

Query: 147  LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG---ERSPDQSEHTDGHTSVQSVI 203
            L ++  QL   L A     +   + +D  + +++ +    E   D +EH  G       +
Sbjct: 1197 LTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQ------L 1250

Query: 204  EKLQEENRLLKQKVTHVEDLN 224
              ++++ RL K     ++D++
Sbjct: 1251 NSMKKDLRLKKLPSKVLDDMD 1271


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.129    0.369 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,045,257
Number of Sequences: 37866
Number of extensions: 812509
Number of successful extensions: 10821
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 162
Number of HSP's successfully gapped in prelim test: 795
Number of HSP's that attempted gapping in prelim test: 6520
Number of HSP's gapped (non-prelim): 3020
length of query: 429
length of database: 18,247,518
effective HSP length: 105
effective length of query: 324
effective length of database: 14,271,588
effective search space: 4623994512
effective search space used: 4623994512
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press