BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|239787092 A20-binding inhibitor of NF-kappaB activation 2 isoform 1 [Homo sapiens] (429 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|239787092 A20-binding inhibitor of NF-kappaB activation 2 iso... 853 0.0 gi|239787094 A20-binding inhibitor of NF-kappaB activation 2 iso... 650 0.0 gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 68 2e-11 gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 68 2e-11 gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 68 2e-11 gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 64 3e-10 gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 62 8e-10 gi|223671870 inhibitor of kappa light polypeptide gene enhancer ... 62 8e-10 gi|4504631 inhibitor of kappa light polypeptide gene enhancer in... 62 8e-10 gi|153792133 inhibitor of kappa light polypeptide gene enhancer ... 62 8e-10 gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 62 1e-09 gi|126723390 ankyrin repeat domain 24 [Homo sapiens] 62 1e-09 gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 61 2e-09 gi|87298937 centrosomal protein 110kDa [Homo sapiens] 61 2e-09 gi|121582655 ankyrin repeat domain 35 [Homo sapiens] 61 2e-09 gi|41322923 plectin 1 isoform 11 [Homo sapiens] 60 3e-09 gi|41322914 plectin 1 isoform 10 [Homo sapiens] 60 3e-09 gi|41322919 plectin 1 isoform 8 [Homo sapiens] 60 3e-09 gi|41322910 plectin 1 isoform 7 [Homo sapiens] 60 3e-09 gi|41322916 plectin 1 isoform 6 [Homo sapiens] 60 3e-09 gi|41322908 plectin 1 isoform 3 [Homo sapiens] 60 3e-09 gi|41322912 plectin 1 isoform 2 [Homo sapiens] 60 3e-09 gi|47607492 plectin 1 isoform 1 [Homo sapiens] 60 3e-09 gi|148746195 trichohyalin [Homo sapiens] 60 4e-09 gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 60 5e-09 gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 60 5e-09 gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 60 5e-09 gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 60 5e-09 gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 60 5e-09 gi|31982906 cingulin-like 1 [Homo sapiens] 60 5e-09 >gi|239787092 A20-binding inhibitor of NF-kappaB activation 2 isoform 1 [Homo sapiens] Length = 429 Score = 853 bits (2203), Expect = 0.0 Identities = 429/429 (100%), Positives = 429/429 (100%) Query: 1 MSRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAA 60 MSRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAA Sbjct: 1 MSRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAA 60 Query: 61 PSLVDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHERE 120 PSLVDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHERE Sbjct: 61 PSLVDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHERE 120 Query: 121 KEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQR 180 KEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQR Sbjct: 121 KEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQR 180 Query: 181 NVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRG 240 NVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRG Sbjct: 181 NVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRG 240 Query: 241 LHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLE 300 LHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLE Sbjct: 241 LHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLE 300 Query: 301 QQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360 QQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK Sbjct: 301 QQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360 Query: 361 YLAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPHCLQCFSDEQGEEL 420 YLAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPHCLQCFSDEQGEEL Sbjct: 361 YLAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPHCLQCFSDEQGEEL 420 Query: 421 LRHVAECCQ 429 LRHVAECCQ Sbjct: 421 LRHVAECCQ 429 >gi|239787094 A20-binding inhibitor of NF-kappaB activation 2 isoform 2 [Homo sapiens] Length = 322 Score = 650 bits (1676), Expect = 0.0 Identities = 322/322 (100%), Positives = 322/322 (100%) Query: 108 MQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQH 167 MQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQH Sbjct: 1 MQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQH 60 Query: 168 LAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW 227 LAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW Sbjct: 61 LAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW 120 Query: 228 QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287 QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT Sbjct: 121 QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 180 Query: 288 ARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREP 347 ARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREP Sbjct: 181 ARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREP 240 Query: 348 DAGRIHAGSKTAKYLAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPH 407 DAGRIHAGSKTAKYLAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPH Sbjct: 241 DAGRIHAGSKTAKYLAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPH 300 Query: 408 CLQCFSDEQGEELLRHVAECCQ 429 CLQCFSDEQGEELLRHVAECCQ Sbjct: 301 CLQCFSDEQGEELLRHVAECCQ 322 >gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] Length = 2003 Score = 67.8 bits (164), Expect = 2e-11 Identities = 84/358 (23%), Positives = 148/358 (41%), Gaps = 29/358 (8%) Query: 15 RAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARF 74 RA L T + + RR +++ A +A R AA E +A + E V R Sbjct: 1386 RAGRELQTAQAQLSEWRRRQEEEAGALEA--GEEARRRAAREAEALTQRLAEKTETVDRL 1443 Query: 75 REQLRRQEGGAAEAQMRQEIER-LTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG 133 RR + +A M E +R L LE+K+R+ QLL++ + + V R+ AEG Sbjct: 1444 ERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEG 1503 Query: 134 ERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHT 193 A + L R+L E + L L + ++V E Sbjct: 1504 REREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHE--------- 1554 Query: 194 DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253 ++ ++ L+ +VT +ED A+ D +R L ++ L+ HE Sbjct: 1555 -----LERACRVAEQAANDLRAQVTELED------ELTAAEDAKLR-LEVTVQALKTQHE 1602 Query: 254 PELMRKEIS--RLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFM 311 +L ++ + RQL +++ D AEV+++ R R A+ + LE ++ K Sbjct: 1603 RDLQGRDEAGEERRRQLAKQLRD-AEVERD--EERKQRTLAVAARKKLEGELEELKAQMA 1659 Query: 312 SERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALEL 369 S +E A ++++++ ++ L +V + SRE + K K L A+ L L Sbjct: 1660 SAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRL 1717 Score = 60.8 bits (146), Expect = 2e-09 Identities = 79/361 (21%), Positives = 154/361 (42%), Gaps = 54/361 (14%) Query: 34 LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEAQMRQE 93 LQ+Q+ + LRA+L E + +L A E AR + +E AA A+ +++ Sbjct: 1092 LQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQED 1151 Query: 94 IER--------------LTERLEEKEREMQQLL------SQPQHEREKEVVLLRRSMAEG 133 +E L E LE E++ L + + +RE+EV L++++ E Sbjct: 1152 LESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEE 1211 Query: 134 ERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG-------ERS 186 R A+ +LR+ Q L + ++ + A+R G Sbjct: 1212 TRIHEAA----------VQELRQ------RHGQALGELAEQLEQARRGKGAWEKTRLALE 1255 Query: 187 PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246 + SE +S+Q+ ++ ++ R L+ ++ V+ +R A E ++ A+L Sbjct: 1256 AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE 1315 Query: 247 GLQ-IPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILA 305 + +E E +S+ E +++D E+ QE ++ A + RV+ +E + Sbjct: 1316 NVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS---RVRAMEAEAAG 1372 Query: 306 YKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAAD 365 ++ E A RERA +Q + +++ WR+ +E +AG + AG + + A + Sbjct: 1373 LREQLEEEAAARERAGRELQTAQAQLS------EWRR-RQEEEAGALEAGEEARRRAARE 1425 Query: 366 A 366 A Sbjct: 1426 A 1426 Score = 60.1 bits (144), Expect = 4e-09 Identities = 71/308 (23%), Positives = 134/308 (43%), Gaps = 27/308 (8%) Query: 71 VARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSM 130 +A ++LR++E G RQE+E+L RL+ + E+Q+ + + Q E+ L R Sbjct: 1061 IADMEDRLRKEEKG------RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKE 1114 Query: 131 AEGERARAASDVLCRSLANETHQLRRTLTATAHM-----CQHLAKCLDERQHAQRNVGER 185 E + A A ++ + A LR A A + +A+ E+Q +R++GE Sbjct: 1115 EELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQ--RRDLGEE 1172 Query: 186 SP---DQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLH 242 + E T T+ Q + +E Q+VT ++ + R + + + +R H Sbjct: 1173 LEALRGELEDTLDSTNAQQELRSKRE------QEVTELKKTLEEETRIHEAAVQELRQRH 1226 Query: 243 AQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQ 302 Q G ++ + E R+ + + +E++ EL++ +TAR +R + LE Q Sbjct: 1227 GQALG-ELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQ 1285 Query: 303 ILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYL 362 + + D ERA++ E ++ + L VS + E R+ + + Sbjct: 1286 L----QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ 1341 Query: 363 AADALELM 370 DA EL+ Sbjct: 1342 LHDAQELL 1349 Score = 50.4 bits (119), Expect = 3e-06 Identities = 75/331 (22%), Positives = 139/331 (41%), Gaps = 46/331 (13%) Query: 29 QRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEA 88 Q+++ LQ Q A + L+ R+A LE E+ AR EQLR + AEA Sbjct: 887 QKVQELQQQSARE---VGELQGRVAQLE------------EERARLAEQLRAEAELCAEA 931 Query: 89 Q--------MRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAAS 140 + +QE+E + LE + E ++ Q Q E+++ ++ A E A Sbjct: 932 EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGAR 991 Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQ 200 L ++++ + +K ER+ + + E S +E Sbjct: 992 QKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEE------- 1044 Query: 201 SVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKE 260 EK++ N+L + + D+ + ++ R E + L +L G E ++++ Sbjct: 1045 ---EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE-LEKLKRRLDG-----ESSELQEQ 1095 Query: 261 ISRLNRQLEEKINDCAEVKQEL-AASRTARDAALERVQMLE-----QQILA-YKDDFMSE 313 + ++ EE ++EL AA A D R Q+L+ Q LA ++D SE Sbjct: 1096 MVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESE 1155 Query: 314 RADRERAQSRIQELEEKVASLLHQVSWRQDS 344 R R +A+ + ++L E++ +L ++ DS Sbjct: 1156 RVARTKAEKQRRDLGEELEALRGELEDTLDS 1186 Score = 46.2 bits (108), Expect = 6e-05 Identities = 79/369 (21%), Positives = 145/369 (39%), Gaps = 59/369 (15%) Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEG------DAAPSLV 64 EE RA A A R L+++ AR+ L + RA A LE D S+ Sbjct: 1494 EERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVH 1553 Query: 65 DALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKER-EMQQLLSQPQHEREKEV 123 + LE+ R EQ AQ+ + + LT + K R E+ + QHER+ + Sbjct: 1554 E--LERACRVAEQAAND----LRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQG 1607 Query: 124 VLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG 183 R E R + A + + + + +RTL A R+ + + Sbjct: 1608 ---RDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAA------------RKKLEGELE 1652 Query: 184 ERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHA 243 E + G + K+Q + + L ++V + N ++ ++GL A Sbjct: 1653 ELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEA 1712 Query: 244 QLRGLQ------------IPHEPELMRKEISRLN----------RQLEEKINDCAEVKQE 281 ++ LQ + + M E++ N RQLE ++ ++++E Sbjct: 1713 EVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLG---QLEEE 1769 Query: 282 LAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWR 341 L ++ + +R + L Q+ + + +ER+ +A+S Q+LE ++ L ++ Sbjct: 1770 LEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLG-- 1827 Query: 342 QDSREPDAG 350 E DAG Sbjct: 1828 ----EEDAG 1832 >gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] Length = 1995 Score = 67.8 bits (164), Expect = 2e-11 Identities = 84/358 (23%), Positives = 148/358 (41%), Gaps = 29/358 (8%) Query: 15 RAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARF 74 RA L T + + RR +++ A +A R AA E +A + E V R Sbjct: 1378 RAGRELQTAQAQLSEWRRRQEEEAGALEA--GEEARRRAAREAEALTQRLAEKTETVDRL 1435 Query: 75 REQLRRQEGGAAEAQMRQEIER-LTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG 133 RR + +A M E +R L LE+K+R+ QLL++ + + V R+ AEG Sbjct: 1436 ERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEG 1495 Query: 134 ERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHT 193 A + L R+L E + L L + ++V E Sbjct: 1496 REREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHE--------- 1546 Query: 194 DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253 ++ ++ L+ +VT +ED A+ D +R L ++ L+ HE Sbjct: 1547 -----LERACRVAEQAANDLRAQVTELED------ELTAAEDAKLR-LEVTVQALKTQHE 1594 Query: 254 PELMRKEIS--RLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFM 311 +L ++ + RQL +++ D AEV+++ R R A+ + LE ++ K Sbjct: 1595 RDLQGRDEAGEERRRQLAKQLRD-AEVERD--EERKQRTLAVAARKKLEGELEELKAQMA 1651 Query: 312 SERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALEL 369 S +E A ++++++ ++ L +V + SRE + K K L A+ L L Sbjct: 1652 SAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRL 1709 Score = 60.8 bits (146), Expect = 2e-09 Identities = 79/361 (21%), Positives = 154/361 (42%), Gaps = 54/361 (14%) Query: 34 LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEAQMRQE 93 LQ+Q+ + LRA+L E + +L A E AR + +E AA A+ +++ Sbjct: 1084 LQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQED 1143 Query: 94 IER--------------LTERLEEKEREMQQLL------SQPQHEREKEVVLLRRSMAEG 133 +E L E LE E++ L + + +RE+EV L++++ E Sbjct: 1144 LESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEE 1203 Query: 134 ERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG-------ERS 186 R A+ +LR+ Q L + ++ + A+R G Sbjct: 1204 TRIHEAA----------VQELRQ------RHGQALGELAEQLEQARRGKGAWEKTRLALE 1247 Query: 187 PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246 + SE +S+Q+ ++ ++ R L+ ++ V+ +R A E ++ A+L Sbjct: 1248 AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE 1307 Query: 247 GLQ-IPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILA 305 + +E E +S+ E +++D E+ QE ++ A + RV+ +E + Sbjct: 1308 NVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS---RVRAMEAEAAG 1364 Query: 306 YKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAAD 365 ++ E A RERA +Q + +++ WR+ +E +AG + AG + + A + Sbjct: 1365 LREQLEEEAAARERAGRELQTAQAQLS------EWRR-RQEEEAGALEAGEEARRRAARE 1417 Query: 366 A 366 A Sbjct: 1418 A 1418 Score = 60.1 bits (144), Expect = 4e-09 Identities = 71/308 (23%), Positives = 134/308 (43%), Gaps = 27/308 (8%) Query: 71 VARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSM 130 +A ++LR++E G RQE+E+L RL+ + E+Q+ + + Q E+ L R Sbjct: 1053 IADMEDRLRKEEKG------RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKE 1106 Query: 131 AEGERARAASDVLCRSLANETHQLRRTLTATAHM-----CQHLAKCLDERQHAQRNVGER 185 E + A A ++ + A LR A A + +A+ E+Q +R++GE Sbjct: 1107 EELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQ--RRDLGEE 1164 Query: 186 SP---DQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLH 242 + E T T+ Q + +E Q+VT ++ + R + + + +R H Sbjct: 1165 LEALRGELEDTLDSTNAQQELRSKRE------QEVTELKKTLEEETRIHEAAVQELRQRH 1218 Query: 243 AQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQ 302 Q G ++ + E R+ + + +E++ EL++ +TAR +R + LE Q Sbjct: 1219 GQALG-ELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQ 1277 Query: 303 ILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYL 362 + + D ERA++ E ++ + L VS + E R+ + + Sbjct: 1278 L----QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ 1333 Query: 363 AADALELM 370 DA EL+ Sbjct: 1334 LHDAQELL 1341 Score = 50.4 bits (119), Expect = 3e-06 Identities = 75/331 (22%), Positives = 139/331 (41%), Gaps = 46/331 (13%) Query: 29 QRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEA 88 Q+++ LQ Q A + L+ R+A LE E+ AR EQLR + AEA Sbjct: 879 QKVQELQQQSARE---VGELQGRVAQLE------------EERARLAEQLRAEAELCAEA 923 Query: 89 Q--------MRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAAS 140 + +QE+E + LE + E ++ Q Q E+++ ++ A E A Sbjct: 924 EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGAR 983 Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQ 200 L ++++ + +K ER+ + + E S +E Sbjct: 984 QKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEE------- 1036 Query: 201 SVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKE 260 EK++ N+L + + D+ + ++ R E + L +L G E ++++ Sbjct: 1037 ---EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE-LEKLKRRLDG-----ESSELQEQ 1087 Query: 261 ISRLNRQLEEKINDCAEVKQEL-AASRTARDAALERVQMLE-----QQILA-YKDDFMSE 313 + ++ EE ++EL AA A D R Q+L+ Q LA ++D SE Sbjct: 1088 MVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESE 1147 Query: 314 RADRERAQSRIQELEEKVASLLHQVSWRQDS 344 R R +A+ + ++L E++ +L ++ DS Sbjct: 1148 RVARTKAEKQRRDLGEELEALRGELEDTLDS 1178 Score = 46.2 bits (108), Expect = 6e-05 Identities = 79/369 (21%), Positives = 145/369 (39%), Gaps = 59/369 (15%) Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEG------DAAPSLV 64 EE RA A A R L+++ AR+ L + RA A LE D S+ Sbjct: 1486 EERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVH 1545 Query: 65 DALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKER-EMQQLLSQPQHEREKEV 123 + LE+ R EQ AQ+ + + LT + K R E+ + QHER+ + Sbjct: 1546 E--LERACRVAEQAAND----LRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQG 1599 Query: 124 VLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG 183 R E R + A + + + + +RTL A R+ + + Sbjct: 1600 ---RDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAA------------RKKLEGELE 1644 Query: 184 ERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHA 243 E + G + K+Q + + L ++V + N ++ ++GL A Sbjct: 1645 ELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEA 1704 Query: 244 QLRGLQ------------IPHEPELMRKEISRLN----------RQLEEKINDCAEVKQE 281 ++ LQ + + M E++ N RQLE ++ ++++E Sbjct: 1705 EVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLG---QLEEE 1761 Query: 282 LAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWR 341 L ++ + +R + L Q+ + + +ER+ +A+S Q+LE ++ L ++ Sbjct: 1762 LEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLG-- 1819 Query: 342 QDSREPDAG 350 E DAG Sbjct: 1820 ----EEDAG 1824 >gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] Length = 2036 Score = 67.8 bits (164), Expect = 2e-11 Identities = 84/358 (23%), Positives = 148/358 (41%), Gaps = 29/358 (8%) Query: 15 RAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARF 74 RA L T + + RR +++ A +A R AA E +A + E V R Sbjct: 1419 RAGRELQTAQAQLSEWRRRQEEEAGALEA--GEEARRRAAREAEALTQRLAEKTETVDRL 1476 Query: 75 REQLRRQEGGAAEAQMRQEIER-LTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG 133 RR + +A M E +R L LE+K+R+ QLL++ + + V R+ AEG Sbjct: 1477 ERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEG 1536 Query: 134 ERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHT 193 A + L R+L E + L L + ++V E Sbjct: 1537 REREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHE--------- 1587 Query: 194 DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253 ++ ++ L+ +VT +ED A+ D +R L ++ L+ HE Sbjct: 1588 -----LERACRVAEQAANDLRAQVTELED------ELTAAEDAKLR-LEVTVQALKTQHE 1635 Query: 254 PELMRKEIS--RLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFM 311 +L ++ + RQL +++ D AEV+++ R R A+ + LE ++ K Sbjct: 1636 RDLQGRDEAGEERRRQLAKQLRD-AEVERD--EERKQRTLAVAARKKLEGELEELKAQMA 1692 Query: 312 SERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALEL 369 S +E A ++++++ ++ L +V + SRE + K K L A+ L L Sbjct: 1693 SAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRL 1750 Score = 60.8 bits (146), Expect = 2e-09 Identities = 79/361 (21%), Positives = 154/361 (42%), Gaps = 54/361 (14%) Query: 34 LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEAQMRQE 93 LQ+Q+ + LRA+L E + +L A E AR + +E AA A+ +++ Sbjct: 1125 LQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQED 1184 Query: 94 IER--------------LTERLEEKEREMQQLL------SQPQHEREKEVVLLRRSMAEG 133 +E L E LE E++ L + + +RE+EV L++++ E Sbjct: 1185 LESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEE 1244 Query: 134 ERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG-------ERS 186 R A+ +LR+ Q L + ++ + A+R G Sbjct: 1245 TRIHEAA----------VQELRQ------RHGQALGELAEQLEQARRGKGAWEKTRLALE 1288 Query: 187 PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246 + SE +S+Q+ ++ ++ R L+ ++ V+ +R A E ++ A+L Sbjct: 1289 AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE 1348 Query: 247 GLQ-IPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILA 305 + +E E +S+ E +++D E+ QE ++ A + RV+ +E + Sbjct: 1349 NVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS---RVRAMEAEAAG 1405 Query: 306 YKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAAD 365 ++ E A RERA +Q + +++ WR+ +E +AG + AG + + A + Sbjct: 1406 LREQLEEEAAARERAGRELQTAQAQLS------EWRR-RQEEEAGALEAGEEARRRAARE 1458 Query: 366 A 366 A Sbjct: 1459 A 1459 Score = 60.1 bits (144), Expect = 4e-09 Identities = 71/308 (23%), Positives = 134/308 (43%), Gaps = 27/308 (8%) Query: 71 VARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSM 130 +A ++LR++E G RQE+E+L RL+ + E+Q+ + + Q E+ L R Sbjct: 1094 IADMEDRLRKEEKG------RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKE 1147 Query: 131 AEGERARAASDVLCRSLANETHQLRRTLTATAHM-----CQHLAKCLDERQHAQRNVGER 185 E + A A ++ + A LR A A + +A+ E+Q +R++GE Sbjct: 1148 EELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQ--RRDLGEE 1205 Query: 186 SP---DQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLH 242 + E T T+ Q + +E Q+VT ++ + R + + + +R H Sbjct: 1206 LEALRGELEDTLDSTNAQQELRSKRE------QEVTELKKTLEEETRIHEAAVQELRQRH 1259 Query: 243 AQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQ 302 Q G ++ + E R+ + + +E++ EL++ +TAR +R + LE Q Sbjct: 1260 GQALG-ELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQ 1318 Query: 303 ILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYL 362 + + D ERA++ E ++ + L VS + E R+ + + Sbjct: 1319 L----QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ 1374 Query: 363 AADALELM 370 DA EL+ Sbjct: 1375 LHDAQELL 1382 Score = 50.4 bits (119), Expect = 3e-06 Identities = 75/331 (22%), Positives = 139/331 (41%), Gaps = 46/331 (13%) Query: 29 QRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEA 88 Q+++ LQ Q A + L+ R+A LE E+ AR EQLR + AEA Sbjct: 920 QKVQELQQQSARE---VGELQGRVAQLE------------EERARLAEQLRAEAELCAEA 964 Query: 89 Q--------MRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAAS 140 + +QE+E + LE + E ++ Q Q E+++ ++ A E A Sbjct: 965 EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGAR 1024 Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQ 200 L ++++ + +K ER+ + + E S +E Sbjct: 1025 QKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEE------- 1077 Query: 201 SVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKE 260 EK++ N+L + + D+ + ++ R E + L +L G E ++++ Sbjct: 1078 ---EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE-LEKLKRRLDG-----ESSELQEQ 1128 Query: 261 ISRLNRQLEEKINDCAEVKQEL-AASRTARDAALERVQMLE-----QQILA-YKDDFMSE 313 + ++ EE ++EL AA A D R Q+L+ Q LA ++D SE Sbjct: 1129 MVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESE 1188 Query: 314 RADRERAQSRIQELEEKVASLLHQVSWRQDS 344 R R +A+ + ++L E++ +L ++ DS Sbjct: 1189 RVARTKAEKQRRDLGEELEALRGELEDTLDS 1219 Score = 46.2 bits (108), Expect = 6e-05 Identities = 79/369 (21%), Positives = 145/369 (39%), Gaps = 59/369 (15%) Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEG------DAAPSLV 64 EE RA A A R L+++ AR+ L + RA A LE D S+ Sbjct: 1527 EERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVH 1586 Query: 65 DALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKER-EMQQLLSQPQHEREKEV 123 + LE+ R EQ AQ+ + + LT + K R E+ + QHER+ + Sbjct: 1587 E--LERACRVAEQAAND----LRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQG 1640 Query: 124 VLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG 183 R E R + A + + + + +RTL A R+ + + Sbjct: 1641 ---RDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAA------------RKKLEGELE 1685 Query: 184 ERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHA 243 E + G + K+Q + + L ++V + N ++ ++GL A Sbjct: 1686 ELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEA 1745 Query: 244 QLRGLQ------------IPHEPELMRKEISRLN----------RQLEEKINDCAEVKQE 281 ++ LQ + + M E++ N RQLE ++ ++++E Sbjct: 1746 EVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLG---QLEEE 1802 Query: 282 LAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWR 341 L ++ + +R + L Q+ + + +ER+ +A+S Q+LE ++ L ++ Sbjct: 1803 LEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLG-- 1860 Query: 342 QDSREPDAG 350 E DAG Sbjct: 1861 ----EEDAG 1865 >gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapiens] Length = 1478 Score = 63.5 bits (153), Expect = 3e-10 Identities = 81/338 (23%), Positives = 141/338 (41%), Gaps = 34/338 (10%) Query: 19 ALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGD--AAPSLVDALLEQVARFRE 76 AL Y QR +Q LA+ +A A +R +E A +A+ Q+A Sbjct: 641 ALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEA 700 Query: 77 QLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG--- 133 L+ +EG Q+R+E+E+ + E + RE++ L SQ Q + + VL +G Sbjct: 701 ILQSKEGECQ--QLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGP 758 Query: 134 ---ERARAASDVLCRSLAN-ETHQ--LRRTLTATAHMCQHLAKCLDERQHAQRNVGERSP 187 AR + L S A E HQ ++R + + LD++ Q + Sbjct: 759 PTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEA 818 Query: 188 DQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNA----------SRDEY 237 EH ++++++L+E+N L + HV++L +R A R+E Sbjct: 819 VLREH-------KTLVQQLKEQNEALNR--AHVQELLQCSEREGALQEERADEAQQREEE 869 Query: 238 VRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQ 297 +R L +L Q E + E + L QL D AE+ ++ A ++ E + Sbjct: 870 LRALQEELS--QAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALA 927 Query: 298 MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLL 335 Q++ K+ ER ER + +Q+ +E + L Sbjct: 928 CAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKL 965 Score = 60.8 bits (146), Expect = 2e-09 Identities = 97/432 (22%), Positives = 169/432 (39%), Gaps = 61/432 (14%) Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVD--------ALLEQVARFREQ 77 E +L Q QL + RL+A++ L+ +L D ++ E V R + Sbjct: 766 ELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKT 825 Query: 78 LRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERAR 137 L +Q EA R ++ L + E+E +Q+ + +RE+E+ L+ +++ A+ Sbjct: 826 LVQQLKEQNEALNRAHVQELLQ-CSEREGALQEERADEAQQREEELRALQEELSQ---AK 881 Query: 138 AASDVLCRSLANETHQLRRTLTATAHM----C----------QHLAKCLDERQHAQRNVG 183 +S+ A QL R T TA + C + LA + E Q A+ Sbjct: 882 CSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAAS 941 Query: 184 ERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHA 243 G +Q E LQE+ + K + L A+ + H Sbjct: 942 REREGLERQVAG---LQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQ 998 Query: 244 QLRGLQIPHEPELMR---------KEISRLNRQLEEK---INDCAEVKQELAASR----- 286 +L L+ E+M +E L QLEE+ + E ++L A++ Sbjct: 999 ELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGE 1058 Query: 287 ----TARDAALERVQML--EQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSW 340 T+ A + ML +++ A ++D + + E+A ++IQE K L +V+ Sbjct: 1059 KLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNK---LCQEVTN 1115 Query: 341 RQDSREPDAGRIHAGSKTAKYLAADALELMVPGGWRPGTGSQQPEPPAEGGHP-GAAQRG 399 R+ + + + ++T KYL +EL+ R Q E A +R Sbjct: 1116 RERNDQKMLADLDDLNRTKKYLEERLIELL-----RDKDALWQKSDALEFQQKLSAEERW 1170 Query: 400 QGDLQCPHCLQC 411 GD + HCL C Sbjct: 1171 LGDTEANHCLDC 1182 Score = 48.1 bits (113), Expect = 1e-05 Identities = 82/371 (22%), Positives = 149/371 (40%), Gaps = 38/371 (10%) Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ-EGG 84 E +R DQL R+ +LR R+ L+ + L V++ EQL+ + E G Sbjct: 230 EGFDEMRLELDQLEVREK---QLRERMQQLDREN-----QELRAAVSQQGEQLQTERERG 281 Query: 85 AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGER----ARAAS 140 A+ + L L+ K+ E+ Q E + + L AE E A Sbjct: 282 RTAAEDNVRLTCLVAELQ-KQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRL 340 Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQ 200 + + + LA E R +L QHLA AQ+ S + + Sbjct: 341 ESMLQPLAQELEATRDSLDKKN---QHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAA 397 Query: 201 SVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKE 260 +++L E+ + L+++ T VE++N ++ +A ++ V+ EL KE Sbjct: 398 QEMQELGEKLQALERERTKVEEVN---RQQSAQLEQLVK---------------ELQLKE 439 Query: 261 ISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERA 320 +R + LE + + A +++EL+ D R+Q L +++++ R ++++ Sbjct: 440 DARAS--LERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQ 497 Query: 321 QSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALELMVPGGWRPG-T 379 Q + LE++V SL Q+ + + + + + K L D L G Sbjct: 498 QEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLA 557 Query: 380 GSQQPEPPAEG 390 G PE P G Sbjct: 558 GPPGPELPVAG 568 >gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] Length = 1960 Score = 62.4 bits (150), Expect = 8e-10 Identities = 78/317 (24%), Positives = 144/317 (45%), Gaps = 51/317 (16%) Query: 33 RLQDQLAARDALIAR---LRARLAALEGDAAPSLVDALLEQVARFREQLRR-QEGGAAEA 88 +LQ+QL A L A LRARL A + + L + + AR E+ R Q A + Sbjct: 884 QLQEQLQAETELCAEAEELRARLTAKKQE----LEEICHDLEARVEEEEERCQHLQAEKK 939 Query: 89 QMRQEIERLTERLEEKEREMQQL-LSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSL 147 +M+Q I+ L E+LEE+E Q+L L + E + + + + + E + + A + + L Sbjct: 940 KMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEK--KLL 997 Query: 148 ANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQ 207 + + LT + LAK ++ +++I L+ Sbjct: 998 EDRIAEFTTNLTEEEEKSKSLAKLKNKH------------------------EAMITDLE 1033 Query: 208 EENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQ 267 E R +++ +E K + + + + L AQ+ L++ +L +KE Sbjct: 1034 ERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKM----QLAKKE------- 1082 Query: 268 LEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQEL 327 EE A V++E A ++ AL++++ LE QI ++D SERA R +A+ + ++L Sbjct: 1083 -EELQAALARVEEEAA----QKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDL 1137 Query: 328 EEKVASLLHQVSWRQDS 344 E++ +L ++ DS Sbjct: 1138 GEELEALKTELEDTLDS 1154 Score = 55.8 bits (133), Expect = 7e-08 Identities = 81/383 (21%), Positives = 167/383 (43%), Gaps = 41/383 (10%) Query: 2 SRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAP 61 S+D E ++ AL E +L L+D+L A + RL L A++ Sbjct: 1512 SKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFER 1571 Query: 62 SLVDALLEQVARFREQLRRQEGGAAEAQMRQEIERLT------ERLEEKEREMQQLLSQP 115 L EQ ++QL RQ EA++ E ++ + ++LE ++++ + Sbjct: 1572 DL-QGRDEQSEEKKKQLVRQV-REMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSA 1629 Query: 116 QHEREKEVVLLRR-------SMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHL 168 R++ + LR+ M E + RA+ + + +L+ + + L Sbjct: 1630 NKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEEL 1689 Query: 169 AKCLDERQHAQRNVGERSPDQSEHTDGHTS--------VQSVIEKLQEENRLLKQKVTHV 220 A ++ AQ+ E + D+ ++ G + +++ I +L+EE L+++ + Sbjct: 1690 AAAERAKRQAQQERDELA-DEIANSSGKGALALEEKRRLEARIAQLEEE---LEEEQGNT 1745 Query: 221 EDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDC-AEVK 279 E +N + ++ N D+ L+ + Q + E R+++ R N++L+ K+ + VK Sbjct: 1746 ELINDRLKKANLQIDQINTDLNLERSHAQ---KNENARQQLERQNKELKVKLQEMEGTVK 1802 Query: 280 QELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339 + AS TA +A ++ LE+Q+ +E +R+ A +++ E+K+ +L QV Sbjct: 1803 SKYKASITALEA---KIAQLEEQL-------DNETKERQAACKQVRRTEKKLKDVLLQVD 1852 Query: 340 WRQDSREPDAGRIHAGSKTAKYL 362 + + E + S K L Sbjct: 1853 DERRNAEQYKDQADKASTRLKQL 1875 Score = 50.4 bits (119), Expect = 3e-06 Identities = 66/293 (22%), Positives = 115/293 (39%), Gaps = 45/293 (15%) Query: 68 LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124 L QV+R E++ +E + + +Q RL E E QL++ Q Q + + E Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAE--NRLTEMETLQSQLMAEKLQLQEQLQAETE 894 Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184 L AE E RA + L H L + CQHL E++ Q+N+ E Sbjct: 895 LC----AEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQA---EKKKMQQNIQE 947 Query: 185 RSPDQSEHTDGHTSVQSVIEKLQEENRL--LKQKVTHVEDLNAKWQRYNASRDEYVRGLH 242 E +Q +EK+ E +L L+++ +ED N K Sbjct: 948 LEEQLEEEESARQKLQ--LEKVTTEAKLKKLEEEQIILEDQNCK---------------- 989 Query: 243 AQLRGLQIPHEPELMRKEISRLNRQL---EEKINDCAEVKQELAASRTARDAALERVQML 299 + E +L+ I+ L EEK A++K + A T + L R + Sbjct: 990 -------LAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQ 1042 Query: 300 EQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRI 352 Q++ + + D +I EL+ ++A L Q++ +++ + R+ Sbjct: 1043 RQELEKTRRKLEGDSTD---LSDQIAELQAQIAELKMQLAKKEEELQAALARV 1092 Score = 49.7 bits (117), Expect = 5e-06 Identities = 51/273 (18%), Positives = 118/273 (43%), Gaps = 30/273 (10%) Query: 101 LEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTA 160 LE+K+++ QLL++ E + + E +RA A + R T Sbjct: 1439 LEKKQKKFDQLLAE-------EKTISAKYAEERDRAEA--------------EAREKETK 1477 Query: 161 TAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKV--- 217 + + L + ++++ +R + + + V + +L++ R L+Q+V Sbjct: 1478 ALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEM 1537 Query: 218 -THVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCA 276 T +E+L + Q A+ D +R L L+ ++ E +L ++ + + ++ + Sbjct: 1538 KTQLEELEDELQ---ATEDAKLR-LEVNLQAMKAQFERDLQGRD-EQSEEKKKQLVRQVR 1592 Query: 277 EVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336 E++ EL R R A+ + LE + + S +R+ A ++++L+ ++ + Sbjct: 1593 EMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMR 1652 Query: 337 QVSWRQDSREPDAGRIHAGSKTAKYLAADALEL 369 ++ + SRE + K K + A+ ++L Sbjct: 1653 ELDDTRASREEILAQAKENEKKLKSMEAEMIQL 1685 Score = 45.1 bits (105), Expect = 1e-04 Identities = 89/410 (21%), Positives = 162/410 (39%), Gaps = 84/410 (20%) Query: 31 LRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG------ 84 L R++++ A ++ + ++R LE + D E+ +R + + ++++ G Sbjct: 1089 LARVEEEAAQKNMALKKIRE----LESQISELQEDLESERASRNKAEKQKRDLGEELEAL 1144 Query: 85 -----------AAEAQMR----QEIERLTERLEEKER-------EMQQLLSQPQHEREKE 122 AA+ ++R QE+ L + LEE+ + EM+Q SQ E ++ Sbjct: 1145 KTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQ 1204 Query: 123 VVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNV 182 + +R A E+A+ + LANE L + + H + + L E Q + N Sbjct: 1205 LEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQ-VKFNE 1263 Query: 183 GER--------------------------SPDQSEHTDGHTSVQSVI----EKLQEENR- 211 GER S+ T ++++S + E LQEENR Sbjct: 1264 GERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQ 1323 Query: 212 --LLKQKVTHVEDLNAKWQRYNASRDE-------YVRGLHAQLRGLQIPHEPELMRKEIS 262 L K+ VED ++ +E + LHAQ+ ++ E + E + Sbjct: 1324 KLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETA 1383 Query: 263 -RLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQ 321 + R+L++ + ++ +E A+ + R+Q +L D + E+ Q Sbjct: 1384 EEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQ 1443 Query: 322 SRIQEL--EEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLA-ADALE 368 + +L EEK S + + E D A K K L+ A ALE Sbjct: 1444 KKFDQLLAEEKTISAKY-------AEERDRAEAEAREKETKALSLARALE 1486 Score = 42.4 bits (98), Expect = 8e-04 Identities = 64/317 (20%), Positives = 132/317 (41%), Gaps = 35/317 (11%) Query: 36 DQLAARDALIA------RLRARLAALEGDA-APSLVDALLE------QVARFREQLR--- 79 DQL A + I+ R RA A E + A SL AL E ++ R +Q R Sbjct: 1447 DQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEM 1506 Query: 80 ------RQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVL---LRRSM 130 + + G + ++ + L +++EE + ++++L + Q + ++ L L+ Sbjct: 1507 EDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMK 1566 Query: 131 AEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQS 190 A+ ER D ++ + ++ L + A+ DER+ V R + Sbjct: 1567 AQFERDLQGRD-------EQSEEKKKQLVRQVREME--AELEDERKQRSMAVAARKKLEM 1617 Query: 191 EHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQ- 249 + D + S + E + L++ ++D + ASR+E + + L+ Sbjct: 1618 DLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKS 1677 Query: 250 IPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDD 309 + E +++E++ R + + E+ E+A S ALE + LE +I +++ Sbjct: 1678 MEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEE 1737 Query: 310 FMSERADRERAQSRIQE 326 E+ + E R+++ Sbjct: 1738 LEEEQGNTELINDRLKK 1754 Score = 38.1 bits (87), Expect = 0.015 Identities = 32/121 (26%), Positives = 60/121 (49%), Gaps = 6/121 (4%) Query: 216 KVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKIND- 274 KV + ++ + + A +E V+ QL E E ++ ++ QL+E++ Sbjct: 833 KVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAE 892 Query: 275 ---CAEVKQELAASRTARDAALERV-QMLEQQILAYKDDFMSERADRERAQSRIQELEEK 330 CAE +EL A TA+ LE + LE ++ ++ +A++++ Q IQELEE+ Sbjct: 893 TELCAEA-EELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQ 951 Query: 331 V 331 + Sbjct: 952 L 952 Score = 33.5 bits (75), Expect = 0.38 Identities = 68/306 (22%), Positives = 120/306 (39%), Gaps = 49/306 (16%) Query: 31 LRRLQDQLAARDALIARLRA---RLAALEGDAAPSLVDALLEQVARFREQLRRQE----- 82 +R L D A+R+ ++A+ + +L ++E + + + A+ + Q R E Sbjct: 1651 MRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEI 1710 Query: 83 -----GGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVL----------LR 127 GA + ++ +E +LEE E E +Q ++ ++R K+ L L Sbjct: 1711 ANSSGKGALALEEKRRLEARIAQLEE-ELEEEQGNTELINDRLKKANLQIDQINTDLNLE 1769 Query: 128 RSMAE-GERARAASDVLCRSLANETHQLRRT--------LTATAHMCQHLAKCLD----E 174 RS A+ E AR + + L + ++ T +TA L + LD E Sbjct: 1770 RSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKE 1829 Query: 175 RQHAQRNVGERSPDQSEHT----DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRY 230 RQ A + V + D + + ++ + + LKQ +E+ + QR Sbjct: 1830 RQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRA 1889 Query: 231 NASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARD 290 NASR + R L + M +E+S L +L D V A + A D Sbjct: 1890 NASRRKLQRELE------DATETADAMNREVSSLKNKLRR--GDLPFVVPRRMARKGAGD 1941 Query: 291 AALERV 296 + E V Sbjct: 1942 GSDEEV 1947 >gi|223671870 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma isoform b [Homo sapiens] Length = 487 Score = 62.4 bits (150), Expect = 8e-10 Identities = 93/426 (21%), Positives = 164/426 (38%), Gaps = 61/426 (14%) Query: 35 QDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAE------- 87 QD L L L + +G AP + LE+ R+ +R+ E Sbjct: 92 QDVLGEESPLGKPAMLHLPSEQG--APETLQRCLEENQELRDAIRQSNQILRERCEELLH 149 Query: 88 --AQMRQEIERLTERLEEKEREMQQL------LSQPQHEREKEVVLLRRSMAEGERARAA 139 A R+E E L + +E + +++L L + + + +EV L+R + +A+ Sbjct: 150 FQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKAS 209 Query: 140 SDVLCRSLANETHQLRRTLTATAHMCQHL-AKCLDERQHAQRNVGERSPDQSEHTDGHTS 198 SL E + + L A CQ L + + A++ ER Q +H+ Sbjct: 210 VKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQ 269 Query: 199 V----QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGL---HAQLRGLQIP 251 + QSV L+ E + ++ + L + + D +++ + RG+Q+ Sbjct: 270 LRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL- 328 Query: 252 HEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFM 311 +++ + +Q EE + EV +L +E V +L+ Q YK DF Sbjct: 329 -------EDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQ 381 Query: 312 SERADRERAQSRIQELEEKVASLLHQ-----VSWRQDSREPDAGRIHAGSKTAKYLAADA 366 +ER RE+ + + L+E++ L + S ++ +R D + H A A A Sbjct: 382 AERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPA 441 Query: 367 L---ELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPHCLQCFSDEQGEELLRH 423 L +P SQ+ PP E D CP C + + L H Sbjct: 442 YLSSPLALP--------SQRRSPPEE----------PPDFCCPKCQ--YQAPDMDTLQIH 481 Query: 424 VAECCQ 429 V EC + Sbjct: 482 VMECIE 487 >gi|4504631 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma isoform a [Homo sapiens] Length = 419 Score = 62.4 bits (150), Expect = 8e-10 Identities = 93/426 (21%), Positives = 164/426 (38%), Gaps = 61/426 (14%) Query: 35 QDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAE------- 87 QD L L L + +G AP + LE+ R+ +R+ E Sbjct: 24 QDVLGEESPLGKPAMLHLPSEQG--APETLQRCLEENQELRDAIRQSNQILRERCEELLH 81 Query: 88 --AQMRQEIERLTERLEEKEREMQQL------LSQPQHEREKEVVLLRRSMAEGERARAA 139 A R+E E L + +E + +++L L + + + +EV L+R + +A+ Sbjct: 82 FQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKAS 141 Query: 140 SDVLCRSLANETHQLRRTLTATAHMCQHL-AKCLDERQHAQRNVGERSPDQSEHTDGHTS 198 SL E + + L A CQ L + + A++ ER Q +H+ Sbjct: 142 VKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQ 201 Query: 199 V----QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGL---HAQLRGLQIP 251 + QSV L+ E + ++ + L + + D +++ + RG+Q+ Sbjct: 202 LRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL- 260 Query: 252 HEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFM 311 +++ + +Q EE + EV +L +E V +L+ Q YK DF Sbjct: 261 -------EDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQ 313 Query: 312 SERADRERAQSRIQELEEKVASLLHQ-----VSWRQDSREPDAGRIHAGSKTAKYLAADA 366 +ER RE+ + + L+E++ L + S ++ +R D + H A A A Sbjct: 314 AERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPA 373 Query: 367 L---ELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPHCLQCFSDEQGEELLRH 423 L +P SQ+ PP E D CP C + + L H Sbjct: 374 YLSSPLALP--------SQRRSPPEE----------PPDFCCPKCQ--YQAPDMDTLQIH 413 Query: 424 VAECCQ 429 V EC + Sbjct: 414 VMECIE 419 >gi|153792133 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma isoform a [Homo sapiens] Length = 419 Score = 62.4 bits (150), Expect = 8e-10 Identities = 93/426 (21%), Positives = 164/426 (38%), Gaps = 61/426 (14%) Query: 35 QDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAE------- 87 QD L L L + +G AP + LE+ R+ +R+ E Sbjct: 24 QDVLGEESPLGKPAMLHLPSEQG--APETLQRCLEENQELRDAIRQSNQILRERCEELLH 81 Query: 88 --AQMRQEIERLTERLEEKEREMQQL------LSQPQHEREKEVVLLRRSMAEGERARAA 139 A R+E E L + +E + +++L L + + + +EV L+R + +A+ Sbjct: 82 FQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKAS 141 Query: 140 SDVLCRSLANETHQLRRTLTATAHMCQHL-AKCLDERQHAQRNVGERSPDQSEHTDGHTS 198 SL E + + L A CQ L + + A++ ER Q +H+ Sbjct: 142 VKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQ 201 Query: 199 V----QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGL---HAQLRGLQIP 251 + QSV L+ E + ++ + L + + D +++ + RG+Q+ Sbjct: 202 LRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL- 260 Query: 252 HEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFM 311 +++ + +Q EE + EV +L +E V +L+ Q YK DF Sbjct: 261 -------EDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQ 313 Query: 312 SERADRERAQSRIQELEEKVASLLHQ-----VSWRQDSREPDAGRIHAGSKTAKYLAADA 366 +ER RE+ + + L+E++ L + S ++ +R D + H A A A Sbjct: 314 AERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPA 373 Query: 367 L---ELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPHCLQCFSDEQGEELLRH 423 L +P SQ+ PP E D CP C + + L H Sbjct: 374 YLSSPLALP--------SQRRSPPEE----------PPDFCCPKCQ--YQAPDMDTLQIH 413 Query: 424 VAECCQ 429 V EC + Sbjct: 414 VMECIE 419 >gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] Length = 2115 Score = 61.6 bits (148), Expect = 1e-09 Identities = 90/428 (21%), Positives = 174/428 (40%), Gaps = 84/428 (19%) Query: 8 GGWEEAPRAAAALCTLYHEAGQRLRRLQDQLA-ARDALIARLRARLAALEGDAAP----- 61 G +EE + ++L T + L + +++L A A ARL A++A+L + Sbjct: 455 GHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATI 514 Query: 62 --------SLVDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS 113 L E+ A+ + L++QE A +R ++E+L+ L++KE++++++ Sbjct: 515 QQQDQELAGLKQQAKEKQAQLAQTLQQQE--QASQGLRHQVEQLSSSLKQKEQQLKEVAE 572 Query: 114 QPQHEREKEVVLLRRSMAEGERARAASDVLCRSL--------------------ANETH- 152 + + R+ L + E E + D + L ANE Sbjct: 573 KQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARD 632 Query: 153 -------QLRRTLTATAHMCQHLAKCLD----ERQHAQRNVGERS----PDQSEHTDGHT 197 Q +R + + L C++ E+ AQ V E +Q + T+ Sbjct: 633 SAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKER 692 Query: 198 SVQSVIEKLQEENRLLKQ--KVTHVEDLNAKWQRYNASRDEY--VRGLHAQLRGLQIPHE 253 Q ++LQE+ + LK+ KVT K + +A ++ + L A+ R L H+ Sbjct: 693 VAQEK-DQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHK 751 Query: 254 PELMRKEISRLNRQ-LEEKINDCAEVKQ--------ELAASRTARDAALERVQMLEQQIL 304 E E R R+ LE ++ E Q ELA + A+ A + L +++ Sbjct: 752 RERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVA 811 Query: 305 AYKDDF------------------MSERADRERAQSRIQELEEKVASLLHQVSWRQDSRE 346 A+++ + M+ + + E+A+ +QE +EKVA + + ++ Sbjct: 812 AWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQ 871 Query: 347 PDAGRIHA 354 + +HA Sbjct: 872 NELAELHA 879 Score = 57.8 bits (138), Expect = 2e-08 Identities = 84/347 (24%), Positives = 136/347 (39%), Gaps = 46/347 (13%) Query: 31 LRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQ----LRRQEGG-- 84 L LQ+++AA +ARL L G+ + L+++ AR ++ L Q+G Sbjct: 902 LSTLQEKMAATSKEVARLET-LVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQF 960 Query: 85 ----AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHER---EKEVVLLRRS-------M 130 AA M +E E++ LE + + Q Q ER E+EV L + + Sbjct: 961 CSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADL 1020 Query: 131 AEGERARAASDVLCRSLANETH--------QLRRTLTATAHMCQHLAKC----------L 172 A + ARA ++ ++ NE L LT Q LAK L Sbjct: 1021 ALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKEL 1080 Query: 173 DERQHAQRNVGER-SPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYN 231 +E + + + E+ + + EH G + + + L+ V L + Q+ Sbjct: 1081 EELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQ 1140 Query: 232 ASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDA 291 D R L A+ R + + L L QLEEK + + LA+++ A Sbjct: 1141 EQADSLERSLEAE-RASRAERDSAL-----ETLQGQLEEKAQELGHSQSALASAQRELAA 1194 Query: 292 ALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV 338 +VQ + +K R + ER S I LEE+V+ L QV Sbjct: 1195 FRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQV 1241 Score = 55.1 bits (131), Expect = 1e-07 Identities = 70/295 (23%), Positives = 126/295 (42%), Gaps = 34/295 (11%) Query: 52 LAALEGDAAPSL--VDALLEQVARFREQLRRQE-----GGAAEAQMRQEIERLTERLEEK 104 LA L G A + ++ L + V + +EQL ++E G A+++ E +LE Sbjct: 1066 LAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEAL 1125 Query: 105 EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAAS-----DVLCRSLANETHQLRRTLT 159 E+ +L Q Q ++E + L RS+ E ERA A + L L + +L + + Sbjct: 1126 RAEVSKLEQQCQKQQE-QADSLERSL-EAERASRAERDSALETLQGQLEEKAQELGHSQS 1183 Query: 160 ATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTH 219 A A + LA + Q + E + S+I L+EE +L ++V Sbjct: 1184 ALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLE 1243 Query: 220 VEDLNAKWQRYNASRDEYVRGLHAQLRGLQIP---------HEPELMRKEISRLNRQLEE 270 E + + +R + E + L +LR LQ +R+E+ L + E+ Sbjct: 1244 KEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEK 1303 Query: 271 KINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQ 325 + ++QEL + ER + L Q++ A+++ F +E+A S +Q Sbjct: 1304 QRVASENLRQELTSQ-------AERAEELGQELKAWQEKFF----QKEQALSTLQ 1347 Score = 47.8 bits (112), Expect = 2e-05 Identities = 83/362 (22%), Positives = 142/362 (39%), Gaps = 34/362 (9%) Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRA-------RLAALEGDAAPSL 63 E + AA L + R+ L+ + ++A + R +L++L D S+ Sbjct: 416 ETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSI 475 Query: 64 VDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEV 123 + L Q EQ + G AQ+ LT +++ Q+L Q +EK+ Sbjct: 476 SN--LSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQA 533 Query: 124 VL---LRRSMAEGERARAASDVLCRSLANETHQL-----RRTLTATAHMCQHLAKCLDER 175 L L++ + R + L SL + QL ++ T H Q LA +ER Sbjct: 534 QLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDH-AQQLATAAEER 592 Query: 176 QHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRD 235 + + R ER + + +E LQ++ ++ + + + QR A Sbjct: 593 EASLR---ERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELS 649 Query: 236 EYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALE 294 V L A + Q HE + E+ R ++K + V QE +D E Sbjct: 650 RKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQE-------KDQLQE 702 Query: 295 RVQMLEQQILAYKDDFMSER---ADRERAQSR-IQELEEKVASLLHQ-VSWRQDSREPDA 349 ++Q L++ + K E+ AD Q R I EL+ + SL+ Q R++ E A Sbjct: 703 QLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERA 762 Query: 350 GR 351 GR Sbjct: 763 GR 764 Score = 47.8 bits (112), Expect = 2e-05 Identities = 73/354 (20%), Positives = 144/354 (40%), Gaps = 50/354 (14%) Query: 30 RLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFRE------QLRRQEG 83 RL++L + A ++ R A A + A S + L+++VA +RE Q Q G Sbjct: 770 RLQQLGEAHQAETEVLRRELAEAMAAQ-HTAESECEQLVKEVAAWRERYEDSQQEEAQYG 828 Query: 84 GAAEAQM----------RQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG 133 + Q+ RQE++ E++ E + +S+ Q+E + L R++ + Sbjct: 829 AMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQV 888 Query: 134 ERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNV-------GERS 186 + + L L+ ++ T A + + K ++++ A R + G+R Sbjct: 889 QEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQ 948 Query: 187 PDQSEHTDGH--TSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQ 244 P+ E G S Q+ ++ ++ E E + + +R A+ E +G + Sbjct: 949 PEWLEEQQGRQFCSTQAALQAMERE----------AEQMGNELERLRAALME-SQGQQQE 997 Query: 245 LRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQIL 304 RG Q E E+ R R Q + + A + E+ + +E + Q+ L Sbjct: 998 ERGQQ---EREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATL--QEAL 1052 Query: 305 AY-------KDDFMSERADRERAQ-SRIQELEEKVASLLHQVSWRQDSREPDAG 350 A+ KD +++ E AQ ++EL + V L Q++ ++ +G Sbjct: 1053 AHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSG 1106 Score = 47.4 bits (111), Expect = 3e-05 Identities = 87/371 (23%), Positives = 146/371 (39%), Gaps = 45/371 (12%) Query: 18 AALCTLYHEA---GQRLRRLQDQLAARDALIARLRAR----LAALEGDAAPSLVDALLEQ 70 AAL + EA G L RL+ L R + +A L + + D LE+ Sbjct: 965 AALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEK 1024 Query: 71 VARFREQLRRQEG-GAAEAQMRQEIERLTERLEEKEREMQQLLS---------QPQHERE 120 AR ++R Q + E L L EKE + Q+L + E Sbjct: 1025 AARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELR 1084 Query: 121 KEVVLLRRSMAEGERARAASDVLCRSLANETHQ-------LRRTLTATAHMCQHLAKCLD 173 + V L+ +A+ E+ A+ A T LR ++ CQ K + Sbjct: 1085 QTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQ---KQQE 1141 Query: 174 ERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEE----NRLLKQKVTHVEDLNAKWQR 229 + +R++ ++E ++Q +E+ +E L + K Q Sbjct: 1142 QADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQD 1201 Query: 230 YNASRDEYVRGLHAQL-RGLQIPHEPELM----RKEISRLNRQLEEKINDCAEVKQELAA 284 ++ + DE+ AQ+ RG Q + +E+S LNRQ+ EK + E+K+ + A Sbjct: 1202 HSKAEDEW----KAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMA 1257 Query: 285 SRTARDAALERVQMLEQQILAYKDDFMSERAD--RERAQSRIQELE-EKVAS-LLHQVSW 340 ER+++L+ + A +ER+ RE QS +E E ++VAS L Q Sbjct: 1258 ESEKSQKLEERLRLLQAE-TASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELT 1316 Query: 341 RQDSREPDAGR 351 Q R + G+ Sbjct: 1317 SQAERAEELGQ 1327 Score = 38.1 bits (87), Expect = 0.015 Identities = 77/353 (21%), Positives = 139/353 (39%), Gaps = 43/353 (12%) Query: 25 HEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLE---QVARFREQLRRQ 81 H+A + +R L+ Q A + L G A + D L Q+ R ++QL + Sbjct: 173 HQAKREIRFLELQKVASSSSGNNF------LSGSPASPMGDILQTPQFQMRRLKKQLADE 226 Query: 82 EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASD 141 E ++ E+ + L EK+ ++ + +R + LL A A Sbjct: 227 RSNRDELEL--ELAENRKLLTEKDAQIAMM-----QQRIDRLALLNEKQA----ASPLEP 275 Query: 142 VLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQS----EHTDGHT 197 L ++ L L T CQ L + + E + D S E Sbjct: 276 KELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQ 335 Query: 198 SVQSVIEKLQEEN-----RLLKQKVTHVEDLNAKWQRYNA--SRDEYVRGLHAQLRG--L 248 +Q + +L EE+ L+++ ++L+A Q ++E ++G +QL Sbjct: 336 QLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLS 395 Query: 249 QIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALE-RVQMLEQQILAYK 307 Q+ P + E+ QLE +KQE AA+ A + L+ RV+MLE + + Sbjct: 396 QLQDNPPQEKGEVLGDVLQLET-------LKQE-AATLAANNTQLQARVEMLETERGQQE 447 Query: 308 DDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360 ++ER E + ++ L + S + +S ++ E A + H TA+ Sbjct: 448 AKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELE-QASQAHGARLTAQ 499 Score = 28.9 bits (63), Expect = 9.4 Identities = 40/186 (21%), Positives = 72/186 (38%), Gaps = 29/186 (15%) Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDA--LLEQVARFREQLRRQEG 83 E +++ L +LA D + +L A++ S +A L Q+ + QL ++E Sbjct: 1546 EQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQ 1605 Query: 84 GA---------------AEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRR 128 A A+ Q QE++ LE+ ++E ++L ++ + L Sbjct: 1606 AAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAER--------LGH 1657 Query: 129 SMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPD 188 + + ++ CR L T Q+R AH Q L + L + Q A + R P Sbjct: 1658 ELQQAGLKTKEAEQTCRHL---TAQVRSLEAQVAHADQQL-RDLGKFQVATDALKSREPQ 1713 Query: 189 QSEHTD 194 D Sbjct: 1714 AKPQLD 1719 >gi|126723390 ankyrin repeat domain 24 [Homo sapiens] Length = 1146 Score = 61.6 bits (148), Expect = 1e-09 Identities = 83/358 (23%), Positives = 147/358 (41%), Gaps = 56/358 (15%) Query: 14 PRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVAR 73 P AA A L E R+R L++ L R R R AA E +AA +A + R Sbjct: 712 PGAAEASEKLQVELETRIRGLEEAL--------RQREREAAAELEAALGKCEAAEAEAGR 763 Query: 74 FREQLRRQEGGAAE-------AQMRQEIERLTERLEEKEREMQQL------LSQPQHER- 119 RE++R EG A Q+R +E+ E L +++ +++L L + + R Sbjct: 764 LRERVREAEGSGASGGGGGDTTQLRAALEQAREDLRDRDSRLRELEAASACLDEARASRL 823 Query: 120 --EKEVVLLRRSMAEGERARAAS----DVLCRSLANETHQLRRTLTATAHMCQHLAKCLD 173 E+E LR +A+ E AR +VL LA + TA A + + Sbjct: 824 LAEEEARGLRAELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGR------- 876 Query: 174 ERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQE------ENRLLKQKVTHVEDLNAKW 227 R A+ V E E G ++ E L++ E+R L+++ + A Sbjct: 877 ARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASL 936 Query: 228 QRYNASRDEYVRGLHAQLRGLQI------PHEPEL---------MRKEISRLNRQLEEKI 272 ++ + + L A+L ++ HE + + ++ L R+ E+ Sbjct: 937 EQEVVATGKEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTS 996 Query: 273 NDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEK 330 + +V++E ++ R AA ++ EQQ+ + + R + RAQ + + +EK Sbjct: 997 AEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEK 1054 Score = 36.2 bits (82), Expect = 0.059 Identities = 81/368 (22%), Positives = 135/368 (36%), Gaps = 79/368 (21%) Query: 67 LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHE-----REK 121 LL+++ + R++ + EA +ER + E+QQLL + Q E RE Sbjct: 336 LLQKIRGLEQHKERRQQESPEASSLHILERQVQ-------ELQQLLVERQEEKESLGREV 388 Query: 122 EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRN 181 E + R S+ E ER + DV +L +E +L A + + L Sbjct: 389 ESLQSRLSLLENERENTSYDV--TTLQDEEGELPDLPGAEVLLSRQL------------- 433 Query: 182 VGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQR------------ 229 SP EH S+Q + L +N+ L +KV +E+ + Sbjct: 434 ----SPSAQEHL---ASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIPL 486 Query: 230 --YNASRDEY--VRGLHAQ-LRGLQIPHEPELMRKEIS--------------------RL 264 Y++ R E+ +R HA+ L+ L+ E+ R+E + L Sbjct: 487 ALYDSLRAEFDQLRRQHAEALQALRQQETREVPREEGAACGESEVAGATATKNGPTHMEL 546 Query: 265 NRQL--EEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQS 322 N + E K+N + +E A T +E + A A+ Sbjct: 547 NGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGAEV 606 Query: 323 RIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALELMVPGGWRPGTGSQ 382 R E E+ A++ + + Q + G G + K A +A E+ G G+ Sbjct: 607 REMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEA-EMQA-----YGVGAG 660 Query: 383 QPEPPAEG 390 Q EPP G Sbjct: 661 QAEPPVTG 668 >gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] Length = 1976 Score = 61.2 bits (147), Expect = 2e-09 Identities = 66/322 (20%), Positives = 148/322 (45%), Gaps = 33/322 (10%) Query: 30 RLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ-----EGG 84 ++ R +++L A+D + +++ + +EG+ LE++ R +QL + E Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGE---------LEEMERKHQQLLEEKNILAEQL 896 Query: 85 AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLC 144 AE ++ E E + RL K++E++++L + E+E + E ++ +A L Sbjct: 897 QAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLE 956 Query: 145 RSL-----ANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV 199 L A + QL + +TA A + + + L + + E+ + + + + Sbjct: 957 EQLDEEEGARQKLQLEK-VTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQL 1015 Query: 200 QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259 EK + ++ ++ + DL + ++ +R E + ++ E ++ Sbjct: 1016 AEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKR------KLDGETTDLQD 1069 Query: 260 EISRLNRQLEEKINDCAEVKQELAASRTARDA-------ALERVQMLEQQILAYKDDFMS 312 +I+ L Q++E A+ ++EL + D AL+ V+ L+ QI ++DF S Sbjct: 1070 QIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFES 1129 Query: 313 ERADRERAQSRIQELEEKVASL 334 E+A R +A+ + ++L E++ +L Sbjct: 1130 EKASRNKAEKQKRDLSEELEAL 1151 Score = 58.5 bits (140), Expect = 1e-08 Identities = 83/405 (20%), Positives = 172/405 (42%), Gaps = 49/405 (12%) Query: 2 SRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAP 61 S+D E ++ AL E +L L+D+L A + RL + A++ Sbjct: 1519 SKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER 1578 Query: 62 SLVDA----------LLEQVARFREQL---RRQEGGAAEAQMRQEIER--LTERLEEKER 106 L L++QV +L R+Q A ++ + EI+ L ++E + Sbjct: 1579 DLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANK 1638 Query: 107 EMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQ 166 +++ Q + K ++ E E ARA+ D + +L+ + + Sbjct: 1639 ARDEVIKQLR----KLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQE 1694 Query: 167 HLAKCLDERQHAQRNVGERSPDQSEHTDGHTS-------VQSVIEKLQEENRLLKQKVTH 219 LA R+HA++ E + + + G ++ +++ I +L+EE L+++ ++ Sbjct: 1695 ELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEE---LEEEQSN 1751 Query: 220 VEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDC-AEV 278 +E LN ++++ D L A+ Q + + R+++ R N++L+ K+ + V Sbjct: 1752 MELLNDRFRKTTLQVDTLNAELAAERSAAQ---KSDNARQQLERQNKELKAKLQELEGAV 1808 Query: 279 KQELAASRTARDAALERV-QMLEQQI--------------LAYKDDFMSERADRERAQSR 323 K + A+ +A +A + ++ + LEQ+ K+ FM +R A + Sbjct: 1809 KSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHA-DQ 1867 Query: 324 IQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368 +E EK + + Q+ + + E +A R +A + + DA E Sbjct: 1868 YKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATE 1912 Score = 47.0 bits (110), Expect = 3e-05 Identities = 72/371 (19%), Positives = 153/371 (41%), Gaps = 71/371 (19%) Query: 30 RLRRLQDQLAARDAL---IARLRARLAALEGDAAPSLVDALLEQVARFREQL----RRQE 82 R+ QLA + +A++R + + D ++ L++ + R++L R+ + Sbjct: 1007 RIAECSSQLAEEEEKAKNLAKIRNKQEVMISD-----LEERLKKEEKTRQELEKAKRKLD 1061 Query: 83 GGAAE-----AQMRQEIERLTERLEEKEREMQQLLSQPQHER-------------EKEVV 124 G + A+++ +I+ L +L +KE E+Q L++ E + ++ Sbjct: 1062 GETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIA 1121 Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184 L+ + +R ++ R L+ E L+ L T A + R ++ V E Sbjct: 1122 ELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTT---AAQQELRTKREQEVAE 1178 Query: 185 RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQ---RYNASRDEYVRGL 241 E T H ++ I+ +++ + T +E+L+ + + R+ A+ ++ +GL Sbjct: 1179 LKKALEEETKNH---EAQIQDMRQRH------ATALEELSEQLEQAKRFKANLEKNKQGL 1229 Query: 242 HAQLRGL--------QIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAAL 293 + L Q+ E E RK++ ++L K+++ ++ ELA + L Sbjct: 1230 ETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNEL 1289 Query: 294 ERVQ------------------MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLL 335 + V LE Q+ ++ E + SRI++LEE+ SL Sbjct: 1290 DNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQ 1349 Query: 336 HQVSWRQDSRE 346 Q +++R+ Sbjct: 1350 EQQEEEEEARK 1360 Score = 46.6 bits (109), Expect = 4e-05 Identities = 86/380 (22%), Positives = 149/380 (39%), Gaps = 54/380 (14%) Query: 34 LQDQLAARDALIARLRARLAALEGDAAPSL----------------VDALLEQVARFREQ 77 LQDQ+A A I L+ +LA E + +L V L Q+A +E Sbjct: 1067 LQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQED 1126 Query: 78 LRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS------QPQHEREKEVVLLRRSMA 131 ++ +A+ ++ L+E LE + E++ L + + +RE+EV L++++ Sbjct: 1127 FESEKASRNKAEKQKR--DLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALE 1184 Query: 132 EGERARAASDVLCRSL-ANETHQLRRTLTATAHMCQHLAKC-----LDERQHA-QRNVGE 184 E + A R A +L L +L K D ++ A + V + Sbjct: 1185 EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQ 1244 Query: 185 RSPDQSEHTDGH--TSVQSVIEKLQEENRL----------LKQKVTHVEDLNAKWQRYNA 232 + +SEH VQ + K+ E +RL L+ ++ +V L + ++ Sbjct: 1245 QVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGI 1304 Query: 233 SRDEYVRGLHAQLRGLQIPHEPELMRK-EISRLNRQLEEKINDCAEVKQELAASRTARDA 291 + L +QL+ Q + E +K +S RQLEE+ N E ++E +R Sbjct: 1305 KFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEAR----- 1359 Query: 292 ALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGR 351 + LE+Q+LA + + + I+ LEE LL E A Sbjct: 1360 -----KNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALA 1414 Query: 352 IHAGSKTAKYLAADALELMV 371 KT L + +L V Sbjct: 1415 YDKLEKTKNRLQQELDDLTV 1434 Score = 37.7 bits (86), Expect = 0.020 Identities = 71/349 (20%), Positives = 132/349 (37%), Gaps = 63/349 (18%) Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85 E ++ +LQ++L L+ + DAA SL L + +E+ R++ + Sbjct: 1277 ELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAA-SLESQLQDTQELLQEETRQKLNLS 1335 Query: 86 AEA-QMRQEIERLTERLEEKER-----EMQQLLSQPQ------------------HEREK 121 + Q+ +E L E+ EE+E E Q L Q Q E +K Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395 Query: 122 EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQH---- 177 +++ ++++ +A + N Q LT + +A L+++Q Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455 Query: 178 --------AQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQR 229 + R ER ++E + T S+ L+E ++ + L A + Sbjct: 1456 LLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMED 1515 Query: 230 YNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR 289 +S+D+ + +H + K L +Q+EE E++ EL A+ A+ Sbjct: 1516 LMSSKDDVGKNVHE-------------LEKSKRALEQQVEEMRTQLEELEDELQATEDAK 1562 Query: 290 DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV 338 LE + A K F + Q+R ++ EEK L+ QV Sbjct: 1563 -------LRLEVNMQAMKAQFERD------LQTRDEQNEEKKRLLIKQV 1598 Score = 33.5 bits (75), Expect = 0.38 Identities = 34/148 (22%), Positives = 74/148 (50%), Gaps = 5/148 (3%) Query: 197 TSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRG-LQIPHEPE 255 T + ++ EE +K+K T VE + +R + E L QL+ ++ E E Sbjct: 848 TRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAE 907 Query: 256 LMRKEISRLNRQLEEKINDC-AEVKQELAASRTARDAALE---RVQMLEQQILAYKDDFM 311 MR ++ ++LEE ++D + V++E ++ ++ + +Q LE+Q+ + Sbjct: 908 EMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQ 967 Query: 312 SERADRERAQSRIQELEEKVASLLHQVS 339 + ++ A+++I+++EE++ L Q S Sbjct: 968 KLQLEKVTAEAKIKKMEEEILLLEDQNS 995 Score = 32.0 bits (71), Expect = 1.1 Identities = 42/205 (20%), Positives = 81/205 (39%), Gaps = 42/205 (20%) Query: 64 VDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEV 123 VD L ++A R ++ + A Q+ ++ + L +L+E E ++ E ++ Sbjct: 1766 VDTLNAELAAERSAAQKSDN--ARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKI 1823 Query: 124 VLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG 183 L + + + RAA++ L R + ++ + DER+HA Sbjct: 1824 GQLEEQLEQEAKERAAANKLVRRTEKKLKEI-------------FMQVEDERRHA----- 1865 Query: 184 ERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHA 243 DQ + E++++ N +KQ +E+ + R NASR + R L Sbjct: 1866 ----DQYK------------EQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELD- 1908 Query: 244 QLRGLQIPHEPELMRKEISRLNRQL 268 E + +E+S L +L Sbjct: 1909 -----DATEANEGLSREVSTLKNRL 1928 >gi|87298937 centrosomal protein 110kDa [Homo sapiens] Length = 2325 Score = 60.8 bits (146), Expect = 2e-09 Identities = 76/349 (21%), Positives = 146/349 (41%), Gaps = 44/349 (12%) Query: 24 YHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEG 83 Y + RL + ++A I L +L + A +L L ++ +E L +G Sbjct: 571 YQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKG 630 Query: 84 GAAEAQ-----MRQEIERLTERLEEKEREMQQL--LSQPQHEREKEVVLLRRSMAEGERA 136 A +AQ +R E E L +RL E E+E QL ++ KE+ L ++ E Sbjct: 631 QATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEV 690 Query: 137 RAASDVLCRSLAN--------------ETHQLRRTLTATAHMCQ----HLAKCLDERQHA 178 A+ L+ E +QL+ L + Q L L++ + A Sbjct: 691 NASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQA 750 Query: 179 QRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQK-------VTHVEDLNAKWQRYN 231 +N ++ E ++ + + ++ LQ++N LLKQ+ + HV D + + Sbjct: 751 LKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVA 810 Query: 232 ASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDA 291 A DE R L + I +++ K ++ L +Q E + A K E ++ Sbjct: 811 ARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEIL---ARSKWERDEAQVRERK 867 Query: 292 ALERVQMLEQQILAYKDDFMS--ERA-------DRERAQSRIQELEEKV 331 E + + ++++ +++F ERA D+ + ++RIQ++E ++ Sbjct: 868 LQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEI 916 Score = 48.5 bits (114), Expect = 1e-05 Identities = 76/321 (23%), Positives = 139/321 (43%), Gaps = 47/321 (14%) Query: 35 QDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAE-AQMRQE 93 Q ++A D + + L L+G ++++ A +E LR E E +E Sbjct: 1593 QQEMAVLDRQLGHKKEELHLLQG--------SMVQAKADLQEALRLGETEVTEKCNHIRE 1644 Query: 94 IERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQ 153 ++ L E L ++ E+ +S ER+ ++ L+++ + E+ V+ R ++ + Sbjct: 1645 VKSLLEELSFQKGELNVQIS----ERKTQLTLIKQEI---EKEEENLQVVLRQMSKHKTE 1697 Query: 154 LRRTLTATA---HMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEEN 210 L+ L H Q L + QH QR V E T V + EKL+ EN Sbjct: 1698 LKNILDMLQLENHELQGL-----KLQHDQR-VSELEK---------TQVAVLEEKLELEN 1742 Query: 211 RLLKQKVTHVEDLNAKWQRYNASRDEY-VRGLHAQLRGLQIPHEPELMRKEISRLNRQLE 269 Q+++ + +WQ+ RD+ + + A+ R LQ E + KE L + + Sbjct: 1743 L---QQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSC--VECLSKEKEDLQEKCD 1797 Query: 270 EKINDCAEVKQELAASRT---ARDAALERVQM----LEQQILAYKDDFMSERADRERAQS 322 A+ K+ LAA+ + LE++++ L+Q++ D +S D Q Sbjct: 1798 IWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQ 1857 Query: 323 RIQELEEKVASLLHQVSWRQD 343 ++QE E V SL +++ QD Sbjct: 1858 QLQEKREAVNSLQEELANVQD 1878 Score = 46.6 bits (109), Expect = 4e-05 Identities = 69/340 (20%), Positives = 136/340 (40%), Gaps = 31/340 (9%) Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQ-------DQLAARDALIARLRARLAALEGD--AAP 61 EE R A +A Q+LR LQ ++ ++ + +AA + D Sbjct: 1478 EELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLS 1537 Query: 62 SLVDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREK 121 + L E++ + ++ + E E Q ++ L+ K E+++L SQ ++++ Sbjct: 1538 KKKEKLTEELQKLQKDIEMAERN--EDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQE 1595 Query: 122 EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRN 181 VL R+ + E + ++ A+ LR T C H+ + + Sbjct: 1596 MAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQ 1655 Query: 182 VGERSPDQSEHTDGHTSVQSVIEKLQEENR--LLKQKVTHVEDLNAKWQRYNASRDEYVR 239 GE + SE T ++ IEK +EEN +L+Q H +L E Sbjct: 1656 KGELNVQISERKTQLTLIKQEIEK-EEENLQVVLRQMSKHKTELKNILDMLQLENHE--- 1711 Query: 240 GLHAQLRGLQIPHE---PELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALER- 295 L+GL++ H+ EL + +++ L +LE + + ++ Q+ + LER Sbjct: 1712 -----LQGLKLQHDQRVSELEKTQVAVLEEKLE--LENLQQISQQQKGEIEWQKQLLERD 1764 Query: 296 ---VQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVA 332 ++ + + A + ++E Q + E+K+A Sbjct: 1765 KREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLA 1804 Score = 41.6 bits (96), Expect = 0.001 Identities = 85/380 (22%), Positives = 157/380 (41%), Gaps = 56/380 (14%) Query: 26 EAGQRLRRLQDQLAARDALIAR---------LRARLAALEGDAAP--SLVDALLEQVARF 74 EA R R+LQ+++A + +A RA A + D + + + ++ Sbjct: 860 EAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYL 919 Query: 75 REQLRRQEG--GAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAE 132 +E L+ E G + Q+ QE + ER+ + RE+++ + +++V L + + + Sbjct: 920 QENLKSMEEIQGLTDLQL-QEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKK 978 Query: 133 GERARAASDVLCRS-LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSE 191 ++A A SD L + L QL+ + Q A+ L E + R + + D Sbjct: 979 LKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDL-- 1036 Query: 192 HTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIP 251 T ++ IE LQ LL+QK + R + G ++Q+ ++ Sbjct: 1037 -----TRAEAEIELLQ---NLLRQK--------GEQFRLEMEKTGVGTGANSQVLEIEKL 1080 Query: 252 HEP-ELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDF 310 +E E R EI+RL L+ +D ++ + LE + L +++ +Y++D+ Sbjct: 1081 NETMERQRTEIARLQNVLDLTGSD----------NKGGFENVLEEIAELRREV-SYQNDY 1129 Query: 311 MSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALELM 370 +S AD + + + +S +VS D+G KY A+ + Sbjct: 1130 ISSMADPFKRRGYWYFMPPPPSS---KVSSHSSQATKDSG------VGLKYSASTPVRKP 1180 Query: 371 VPGGWRPGTGSQQPEPPAEG 390 PG GSQ PPA G Sbjct: 1181 RPGQQDGKEGSQ--PPPASG 1198 Score = 40.8 bits (94), Expect = 0.002 Identities = 62/280 (22%), Positives = 112/280 (40%), Gaps = 30/280 (10%) Query: 77 QLRRQEGGAAEAQMRQEIERLTER----LEEKER--EMQQLLSQPQHEREKEVVLLRRSM 130 QL E + Q Q + L + LEEK +QQ+ Q + E E + LL R Sbjct: 1706 QLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDK 1765 Query: 131 AEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQS 190 E ER A S R+L + L + C K L + + E S + Sbjct: 1766 REIERMTAES----RALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQ 1821 Query: 191 EHTDGHTSVQSVIEKLQEE-NRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQ 249 + + ++ + KLQ+E ++L + K++ D++A Q+ R E V L +L +Q Sbjct: 1822 SNLE---KLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKR-EAVNSLQEELANVQ 1877 Query: 250 ------------IPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQ 297 +++ E +RL + + E N + ++E + ++ Sbjct: 1878 DHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIE 1937 Query: 298 MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQ 337 E ++ + + M +R +ER +S +LE +L Q Sbjct: 1938 --ENKLKLVQQEMMFQRLQKER-ESEESKLETSKVTLKEQ 1974 Score = 38.9 bits (89), Expect = 0.009 Identities = 60/268 (22%), Positives = 108/268 (40%), Gaps = 30/268 (11%) Query: 87 EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVV--------LLRRSMAEGERARA 138 + M Q +++ E E K + L + QH+ EKE+ +L + +A ER R Sbjct: 1946 QEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRT 2005 Query: 139 ASDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQS------ 190 + C SL Q +R L+ Q L + E Q+ D S Sbjct: 2006 LQEEERWCESLEKTLSQTKRQLSERE---QQLVEKSGELLALQKEADSMRADFSLLRNQF 2062 Query: 191 --EHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGL 248 E V S+ E L+ + L++ + + N+ Q+ A+ + + H + R L Sbjct: 2063 LTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRL 2122 Query: 249 QIPHEPELMRKEISRLNRQLEEKINDCAEVKQELA-ASRTARDAALERVQMLEQQILAYK 307 E M+ E + L +Q+ + D + E++ A RT + + ++ + + Sbjct: 2123 M--KELNQMQYEYTELKKQMANQ-KDLERRQMEISDAMRTLKSEVKDEIRTSLKNL---- 2175 Query: 308 DDFMSE-RADRERAQSRIQELEEKVASL 334 + F+ E AD E R + LE ++ SL Sbjct: 2176 NQFLPELPADLEAILERNENLEGELESL 2203 Score = 36.6 bits (83), Expect = 0.045 Identities = 57/242 (23%), Positives = 100/242 (41%), Gaps = 38/242 (15%) Query: 80 RQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQH--EREKEVVLLRRSMAEGERAR 137 RQE A E +E+ERL LE+K E ++L S+ E K L +S+ E + Sbjct: 260 RQE--AFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQ 317 Query: 138 AASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHT 197 S +S N ++L + T + C + + Q + + E + + Sbjct: 318 KQSCEELKSDLNTKNELLKQKT-----IELTRACQKQYELEQELAFYKIDAKFEPLNYYP 372 Query: 198 SVQSVIEKLQEEN---------RLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGL 248 S + I+K +E+ R + +++ D Q DE +R H LRG Sbjct: 373 SEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRG- 431 Query: 249 QIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308 H P L+ QLE+K +++++A++T + ++ EQQIL + Sbjct: 432 ---HTP---------LDTQLEDK-------EKKISAAQTRLSELHDEIEKAEQQILRATE 472 Query: 309 DF 310 +F Sbjct: 473 EF 474 >gi|121582655 ankyrin repeat domain 35 [Homo sapiens] Length = 1001 Score = 60.8 bits (146), Expect = 2e-09 Identities = 70/309 (22%), Positives = 131/309 (42%), Gaps = 31/309 (10%) Query: 83 GGAAEAQMRQEIE-------RLTERLEEKEREMQQLLSQPQ---HEREKEVVLLRRSMAE 132 GG A+ Q+ +E+ L E L E RE Q+L + Q ++E V + + Sbjct: 606 GGLAKGQLEKEMSVLRLSNSNLLEELGELGRERQRLQRELQSLSQRLQREFVPKPEAQVQ 665 Query: 133 GERARAASDVLCRSLANE---THQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQ 189 ++ R + +L LA E T +LR+ L + + + L CL +R+ ++ + Sbjct: 666 LQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGERSAQSKAAES 725 Query: 190 SEH--------TDGHTSVQSVIEKLQEENRLLKQKVTHVED----LNAKWQRYNASRDEY 237 E D H Q V+ +LQEEN+ L+ ++ + L A A+ ++ Sbjct: 726 LEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCREPGTSLKAPASPQVAALEQD 785 Query: 238 VRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAAS----RTARDAAL 293 + L +LR +Q + +EI +L + L + + AE++ AAS R + + Sbjct: 786 LGKLEEELRAVQATMSGK--SQEIGKLKQLLYQATEEVAELRAREAASLRQHEKTRGSLV 843 Query: 294 ERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIH 353 + Q Q++ A + + + + R + + E + L Q + ++ GR Sbjct: 844 AQAQAWGQELKALLEKYNTACREVGRLREAVAEERRRSGDLAAQAAEQERQASEMRGRSE 903 Query: 354 AGSKTAKYL 362 KTA+ L Sbjct: 904 QFEKTAELL 912 >gi|41322923 plectin 1 isoform 11 [Homo sapiens] Length = 4547 Score = 60.5 bits (145), Expect = 3e-09 Identities = 84/343 (24%), Positives = 141/343 (41%), Gaps = 50/343 (14%) Query: 11 EEAPRAAAALCTLYHEAGQRLR----RLQDQLAARDALIARLRARLAALEGDAAPSLVDA 66 E+A AA L E +R R R+Q LAA + + +A L +E + A Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER------LKA 2016 Query: 67 LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEE---------KEREMQQLLSQPQH 117 +E+ R RE R ++ A + Q+ QE + + EE KE+E+QQ L Q Q Sbjct: 2017 KVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074 Query: 118 EREK---EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE 174 ++ E RR+ E E AR ++ E Q RR + + Q + Sbjct: 2075 VLDQLRGEAEAARRAAEEAEEARVQAE-------REAAQSRRQVEEAERLKQSAEEQAQA 2127 Query: 175 RQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLN------AKWQ 228 R AQ E+ ++E Q + Q E L+QK ++ + Sbjct: 2128 RAQAQA-AAEKLRKEAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178 Query: 229 RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288 R A ++ + L QL + H+ L+ +E+ RL + E ++V++EL + R Sbjct: 2179 RQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236 Query: 289 RD--AALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEE 329 + + L+ E + L +D ++R +E A+ Q EE Sbjct: 2237 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279 Score = 57.8 bits (138), Expect = 2e-08 Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 43/360 (11%) Query: 29 QRLRRLQDQLAARDALIARLRARLAAL---EGDAAPSLVDALLEQVARFREQLRRQEGGA 85 + L ++ Q+ L AR+ A AL + D + E++ + E+ R A Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2287 Query: 86 AEA----QMRQEIERLTERLEEK--EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAA 139 EA Q+ +E L EK + +MQ + + + E E++ ++ +A+ + R Sbjct: 2288 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2347 Query: 140 SDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG-- 195 D + + LA ET +RTL A Q + E + + V E S Q+ + Sbjct: 2348 EDKEQMAQQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2404 Query: 196 --HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253 + + EKL ++KVT V+ L + Q Q H+ Sbjct: 2405 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------------QSDHD 2444 Query: 254 PELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR-DAALERVQMLEQQILAYKDDFMS 312 E +R+ I+ L R+ E+ + ++ + +T + + L+ Q L+Q L+ KD + Sbjct: 2445 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504 Query: 313 ERADRERAQSRIQELEE----KVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368 E+ ++++++L + K L + +Q E + R+ A + A+ +A E Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2564 Score = 51.6 bits (122), Expect = 1e-06 Identities = 86/341 (25%), Positives = 138/341 (40%), Gaps = 26/341 (7%) Query: 26 EAGQRLRR-LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84 E +RLRR +QD+ + L +R+ A E +AA AL + E+LR Q Sbjct: 1494 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRAL-----QALEELRLQ--- 1544 Query: 85 AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG----ERARAAS 140 A EA+ RL + E+ R++Q L Q E E+ R S AE ER+ Sbjct: 1545 AEEAE-----RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1599 Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV- 199 V L E + R A A + A+ ER + N R Q+E S+ Sbjct: 1600 HVAVAQLREEAER-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658 Query: 200 QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259 Q+ EK +EE ++ E+ + + E R L ++ E EL+R Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR- 1717 Query: 260 EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRER 319 L + E+ +++ELA + AA ++ Q LE ++ + + A + R Sbjct: 1718 ----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1773 Query: 320 AQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360 A+ + EK L + R +A R+ A ++ AK Sbjct: 1774 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814 Score = 50.8 bits (120), Expect = 2e-06 Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 32/300 (10%) Query: 27 AGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAA 86 A ++LR+ +Q AAR R +A AAL A DA +E+ +F EQ RQ+ Sbjct: 2134 AAEKLRKEAEQEAAR-----RAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---- 2181 Query: 87 EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRS 146 AQ+ QE+ L +LEE + + L ++E+ L+ E R R+ + S Sbjct: 2182 -AQVEQELTTLRLQLEETDHQKNLL--------DEELQRLKAEATEAARQRSQVEEELFS 2232 Query: 147 LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKL 206 + + +L + ++ A L ++ + QR + E + + + + ++ Sbjct: 2233 VRVQMEELSKLKARIE--AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2290 Query: 207 QEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNR 266 +L ++ + L K + + L A+ LQ + EL +++ RL Sbjct: 2291 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ--QQKELAQEQARRLQE 2348 Query: 267 QLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326 E+ + Q+LA LE + + ++ A + A+ RAQ+R +E Sbjct: 2349 DKEQ-------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2401 Score = 50.4 bits (119), Expect = 3e-06 Identities = 84/403 (20%), Positives = 165/403 (40%), Gaps = 32/403 (7%) Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85 EA +R + + + R+ L + EG A L A +++ R R + ++G Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAET--EQGEQ 1727 Query: 86 AEAQMRQEIERLTERLEEKEREMQQLLSQPQHER-EKEVVLLRRSMAEGERARAASDVLC 144 + +E+ RL ++ Q+L ++ R E EV+L ++ AE E +R+ S+ Sbjct: 1728 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE-EESRSTSEKSK 1786 Query: 145 RSLANETHQLR---------RTLTATAHMCQHLAK--CLDERQHAQRNVGERSPDQSEHT 193 + L E + R R L A + LA+ +R A+R + E+ E T Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846 Query: 194 DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253 T + +++ + EN L++ ED + +R ++ + +L L+ + Sbjct: 1847 RLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903 Query: 254 PELMR-----KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308 EL R ++ R RQ+EE+I ++ AA + + L R++ + L K+ Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963 Query: 309 DFMSE-------RADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKY 361 E A+ ER + +E +K + + + ++ + + R+ A + A+ Sbjct: 1964 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2023 Query: 362 LAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQ 404 L A + +Q+ E H A Q+ + +LQ Sbjct: 2024 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2066 Score = 49.3 bits (116), Expect = 7e-06 Identities = 75/329 (22%), Positives = 133/329 (40%), Gaps = 51/329 (15%) Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ---- 81 EA QR RRL++Q A A I A+L D+ L+E R R Q+ + Sbjct: 1873 EAFQR-RRLEEQAAQHKADIEERLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILAL 1930 Query: 82 -----EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERA 136 + A +A++ E+ R+ E+ R +Q E E R+ AE ER Sbjct: 1931 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA--------ELEAARQRQLAAEEERR 1982 Query: 137 RA-ASDVLCRSLANETHQLRRT---------LTATAHMCQHLAKCLDERQHAQRNVGERS 186 R A + + +SLA E R+ L A + L + ++ Q + + + Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2042 Query: 187 PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246 + + +V +K QE + L+Q+ + ++ L + + + +E A+ Sbjct: 2043 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEA 2096 Query: 247 GLQIPHEPELMRKEIS---RLNRQLEEKINDCA-----------EVKQELAASRTARDAA 292 +Q E R+++ RL + EE+ A E +QE A A AA Sbjct: 2097 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2156 Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQ 321 L + Q + ++ +K +E+ R++AQ Sbjct: 2157 LRQKQAADAEMEKHKK--FAEQTLRQKAQ 2183 Score = 47.4 bits (111), Expect = 3e-05 Identities = 89/393 (22%), Positives = 165/393 (41%), Gaps = 72/393 (18%) Query: 33 RLQDQLAARDALIARLRARLAAL---------EGDAAPSLVDALLEQVARFREQL----- 78 RLQ + RD + R R R+A L + D ++ L Q+ +RE Sbjct: 1162 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1221 Query: 79 ------RRQE---------GGAAEAQMRQE------IERLTERLEEKEREMQQLLSQPQH 117 RRQE A Q+RQE IER E++EE +R +Q ++ + Sbjct: 1222 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK- 1280 Query: 118 EREKEVVLLR------RSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKC 171 + E ++V + S A+ + ++ S+ + + + T T+ + +++ Sbjct: 1281 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1340 Query: 172 LDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK---LQEENRLLK-QKVTHVEDLNAKW 227 L + +R ++ ++ E V++ +EK L E + K Q ++L + Sbjct: 1341 LRRMEEEERLAEQQRAEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1397 Query: 228 QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287 Q R+E Q R +Q +E+ +L + E +I A+ +Q AA R+ Sbjct: 1398 QEEVVRREEAAVDAQQQKRSIQ---------EELQQLRQSSEAEIQ--AKARQAEAAERS 1446 Query: 288 ----ARDAALERVQM--LEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV--- 338 + + R+Q+ E+Q + + + RA E A+++ ++ +E+ L QV Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506 Query: 339 SWRQDSREPD-AGRIHAGSKTA--KYLAADALE 368 S R+ E + A R+ A ++ A K A ALE Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALE 1539 Score = 47.0 bits (110), Expect = 3e-05 Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 46/353 (13%) Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIAR--LRARLAAL-EGDAAPSLVDAL 67 EEA R + A + RLR+L ++ A+ +A L+ ++ A+ E + + L Sbjct: 2278 EEAARLSVAA-----QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2332 Query: 68 LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124 +Q +EQ RR ++++ E++ ++L E+ + Q+ L Q Q E E Sbjct: 2333 QQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2383 Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184 L+ +AE RA+A ++ + + ++ L T Q L + QR + Sbjct: 2384 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSD 2442 Query: 185 RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW--QRYNASRDEYVRGLH 242 D + ++ EKLQ+E +LL+ K ++ + + Q A + ++ Sbjct: 2443 H--DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2500 Query: 243 AQLRGLQIPHEP-----ELMRKEISRLNRQLEEKINDCAEVKQE----LAASRTAR---- 289 + L+ + + +L + E+++ + EE+ +++QE +A+ AR Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2560 Query: 290 ------DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336 E +Q LEQQ +++ ++E R R Q ++ E E+ A+L H Sbjct: 2561 EAEEGVRRKQEELQQLEQQ-RRQQEELLAEENQRLREQLQLLE-EQHRAALAH 2611 Score = 46.2 bits (108), Expect = 6e-05 Identities = 98/393 (24%), Positives = 156/393 (39%), Gaps = 42/393 (10%) Query: 62 SLVDALLEQVARF-REQLRR--QEGGAAEAQMRQEIERLTE--RLEEKEREMQQLLSQPQ 116 S + L Q +F E LRR +E AE Q +E ERL E EK+R++ + +Q + Sbjct: 1324 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1383 Query: 117 HEREKEVVLLRRSMAEG----ERARAASDVLCRSLANETHQLRRTLTA-------TAHMC 165 + E+E L++ M E E A + RS+ E QLR++ A A Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1443 Query: 166 QHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225 + ++E R E + Q +G +Q++ + +E +Q E L Sbjct: 1444 ERSRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRR 1501 Query: 226 KWQRYNASRDEYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAA 284 + Q DE R A++ ++ E E R E R + LEE E ++ L Sbjct: 1502 QVQ------DESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1554 Query: 285 SRTAR----DAALERVQ-MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339 + R ALE Q E ++ + + F + A ER+ +QE VA L + Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAE 1611 Query: 340 WR-QDSREPDAGRIHAGSKTAKY--LAADALELMVPG---GWRPGTGSQQPEPPAEGGHP 393 R Q E + R A + ++ A +AL L + + + E E Sbjct: 1612 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671 Query: 394 GAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAE 426 A +RG+ + Q Q EQ E R +AE Sbjct: 1672 EARRRGKAEEQAVR--QRELAEQELEKQRQLAE 1702 >gi|41322914 plectin 1 isoform 10 [Homo sapiens] Length = 4551 Score = 60.5 bits (145), Expect = 3e-09 Identities = 84/343 (24%), Positives = 141/343 (41%), Gaps = 50/343 (14%) Query: 11 EEAPRAAAALCTLYHEAGQRLR----RLQDQLAARDALIARLRARLAALEGDAAPSLVDA 66 E+A AA L E +R R R+Q LAA + + +A L +E + A Sbjct: 1967 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER------LKA 2020 Query: 67 LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEE---------KEREMQQLLSQPQH 117 +E+ R RE R ++ A + Q+ QE + + EE KE+E+QQ L Q Q Sbjct: 2021 KVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2078 Query: 118 EREK---EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE 174 ++ E RR+ E E AR ++ E Q RR + + Q + Sbjct: 2079 VLDQLRGEAEAARRAAEEAEEARVQAE-------REAAQSRRQVEEAERLKQSAEEQAQA 2131 Query: 175 RQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLN------AKWQ 228 R AQ E+ ++E Q + Q E L+QK ++ + Sbjct: 2132 RAQAQA-AAEKLRKEAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2182 Query: 229 RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288 R A ++ + L QL + H+ L+ +E+ RL + E ++V++EL + R Sbjct: 2183 RQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2240 Query: 289 RD--AALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEE 329 + + L+ E + L +D ++R +E A+ Q EE Sbjct: 2241 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2283 Score = 57.8 bits (138), Expect = 2e-08 Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 43/360 (11%) Query: 29 QRLRRLQDQLAARDALIARLRARLAAL---EGDAAPSLVDALLEQVARFREQLRRQEGGA 85 + L ++ Q+ L AR+ A AL + D + E++ + E+ R A Sbjct: 2232 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2291 Query: 86 AEA----QMRQEIERLTERLEEK--EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAA 139 EA Q+ +E L EK + +MQ + + + E E++ ++ +A+ + R Sbjct: 2292 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2351 Query: 140 SDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG-- 195 D + + LA ET +RTL A Q + E + + V E S Q+ + Sbjct: 2352 EDKEQMAQQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2408 Query: 196 --HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253 + + EKL ++KVT V+ L + Q Q H+ Sbjct: 2409 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------------QSDHD 2448 Query: 254 PELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR-DAALERVQMLEQQILAYKDDFMS 312 E +R+ I+ L R+ E+ + ++ + +T + + L+ Q L+Q L+ KD + Sbjct: 2449 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2508 Query: 313 ERADRERAQSRIQELEE----KVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368 E+ ++++++L + K L + +Q E + R+ A + A+ +A E Sbjct: 2509 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2568 Score = 51.6 bits (122), Expect = 1e-06 Identities = 86/341 (25%), Positives = 138/341 (40%), Gaps = 26/341 (7%) Query: 26 EAGQRLRR-LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84 E +RLRR +QD+ + L +R+ A E +AA AL + E+LR Q Sbjct: 1498 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRAL-----QALEELRLQ--- 1548 Query: 85 AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG----ERARAAS 140 A EA+ RL + E+ R++Q L Q E E+ R S AE ER+ Sbjct: 1549 AEEAE-----RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1603 Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV- 199 V L E + R A A + A+ ER + N R Q+E S+ Sbjct: 1604 HVAVAQLREEAER-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1662 Query: 200 QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259 Q+ EK +EE ++ E+ + + E R L ++ E EL+R Sbjct: 1663 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR- 1721 Query: 260 EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRER 319 L + E+ +++ELA + AA ++ Q LE ++ + + A + R Sbjct: 1722 ----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1777 Query: 320 AQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360 A+ + EK L + R +A R+ A ++ AK Sbjct: 1778 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1818 Score = 50.8 bits (120), Expect = 2e-06 Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 32/300 (10%) Query: 27 AGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAA 86 A ++LR+ +Q AAR R +A AAL A DA +E+ +F EQ RQ+ Sbjct: 2138 AAEKLRKEAEQEAAR-----RAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---- 2185 Query: 87 EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRS 146 AQ+ QE+ L +LEE + + L ++E+ L+ E R R+ + S Sbjct: 2186 -AQVEQELTTLRLQLEETDHQKNLL--------DEELQRLKAEATEAARQRSQVEEELFS 2236 Query: 147 LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKL 206 + + +L + ++ A L ++ + QR + E + + + + ++ Sbjct: 2237 VRVQMEELSKLKARIE--AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2294 Query: 207 QEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNR 266 +L ++ + L K + + L A+ LQ + EL +++ RL Sbjct: 2295 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ--QQKELAQEQARRLQE 2352 Query: 267 QLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326 E+ + Q+LA LE + + ++ A + A+ RAQ+R +E Sbjct: 2353 DKEQ-------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2405 Score = 50.4 bits (119), Expect = 3e-06 Identities = 84/403 (20%), Positives = 165/403 (40%), Gaps = 32/403 (7%) Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85 EA +R + + + R+ L + EG A L A +++ R R + ++G Sbjct: 1676 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAET--EQGEQ 1731 Query: 86 AEAQMRQEIERLTERLEEKEREMQQLLSQPQHER-EKEVVLLRRSMAEGERARAASDVLC 144 + +E+ RL ++ Q+L ++ R E EV+L ++ AE E +R+ S+ Sbjct: 1732 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE-EESRSTSEKSK 1790 Query: 145 RSLANETHQLR---------RTLTATAHMCQHLAK--CLDERQHAQRNVGERSPDQSEHT 193 + L E + R R L A + LA+ +R A+R + E+ E T Sbjct: 1791 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1850 Query: 194 DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253 T + +++ + EN L++ ED + +R ++ + +L L+ + Sbjct: 1851 RLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1907 Query: 254 PELMR-----KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308 EL R ++ R RQ+EE+I ++ AA + + L R++ + L K+ Sbjct: 1908 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1967 Query: 309 DFMSE-------RADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKY 361 E A+ ER + +E +K + + + ++ + + R+ A + A+ Sbjct: 1968 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2027 Query: 362 LAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQ 404 L A + +Q+ E H A Q+ + +LQ Sbjct: 2028 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2070 Score = 49.3 bits (116), Expect = 7e-06 Identities = 75/329 (22%), Positives = 133/329 (40%), Gaps = 51/329 (15%) Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ---- 81 EA QR RRL++Q A A I A+L D+ L+E R R Q+ + Sbjct: 1877 EAFQR-RRLEEQAAQHKADIEERLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILAL 1934 Query: 82 -----EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERA 136 + A +A++ E+ R+ E+ R +Q E E R+ AE ER Sbjct: 1935 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA--------ELEAARQRQLAAEEERR 1986 Query: 137 RA-ASDVLCRSLANETHQLRRT---------LTATAHMCQHLAKCLDERQHAQRNVGERS 186 R A + + +SLA E R+ L A + L + ++ Q + + + Sbjct: 1987 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2046 Query: 187 PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246 + + +V +K QE + L+Q+ + ++ L + + + +E A+ Sbjct: 2047 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEA 2100 Query: 247 GLQIPHEPELMRKEIS---RLNRQLEEKINDCA-----------EVKQELAASRTARDAA 292 +Q E R+++ RL + EE+ A E +QE A A AA Sbjct: 2101 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2160 Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQ 321 L + Q + ++ +K +E+ R++AQ Sbjct: 2161 LRQKQAADAEMEKHKK--FAEQTLRQKAQ 2187 Score = 47.4 bits (111), Expect = 3e-05 Identities = 89/393 (22%), Positives = 165/393 (41%), Gaps = 72/393 (18%) Query: 33 RLQDQLAARDALIARLRARLAAL---------EGDAAPSLVDALLEQVARFREQL----- 78 RLQ + RD + R R R+A L + D ++ L Q+ +RE Sbjct: 1166 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1225 Query: 79 ------RRQE---------GGAAEAQMRQE------IERLTERLEEKEREMQQLLSQPQH 117 RRQE A Q+RQE IER E++EE +R +Q ++ + Sbjct: 1226 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK- 1284 Query: 118 EREKEVVLLR------RSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKC 171 + E ++V + S A+ + ++ S+ + + + T T+ + +++ Sbjct: 1285 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1344 Query: 172 LDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK---LQEENRLLK-QKVTHVEDLNAKW 227 L + +R ++ ++ E V++ +EK L E + K Q ++L + Sbjct: 1345 LRRMEEEERLAEQQRAEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1401 Query: 228 QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287 Q R+E Q R +Q +E+ +L + E +I A+ +Q AA R+ Sbjct: 1402 QEEVVRREEAAVDAQQQKRSIQ---------EELQQLRQSSEAEIQ--AKARQAEAAERS 1450 Query: 288 ----ARDAALERVQM--LEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV--- 338 + + R+Q+ E+Q + + + RA E A+++ ++ +E+ L QV Sbjct: 1451 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1510 Query: 339 SWRQDSREPD-AGRIHAGSKTA--KYLAADALE 368 S R+ E + A R+ A ++ A K A ALE Sbjct: 1511 SQRKRQAEVELASRVKAEAEAAREKQRALQALE 1543 Score = 47.0 bits (110), Expect = 3e-05 Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 46/353 (13%) Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIAR--LRARLAAL-EGDAAPSLVDAL 67 EEA R + A + RLR+L ++ A+ +A L+ ++ A+ E + + L Sbjct: 2282 EEAARLSVAA-----QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2336 Query: 68 LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124 +Q +EQ RR ++++ E++ ++L E+ + Q+ L Q Q E E Sbjct: 2337 QQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2387 Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184 L+ +AE RA+A ++ + + ++ L T Q L + QR + Sbjct: 2388 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSD 2446 Query: 185 RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW--QRYNASRDEYVRGLH 242 D + ++ EKLQ+E +LL+ K ++ + + Q A + ++ Sbjct: 2447 H--DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2504 Query: 243 AQLRGLQIPHEP-----ELMRKEISRLNRQLEEKINDCAEVKQE----LAASRTAR---- 289 + L+ + + +L + E+++ + EE+ +++QE +A+ AR Sbjct: 2505 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2564 Query: 290 ------DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336 E +Q LEQQ +++ ++E R R Q ++ E E+ A+L H Sbjct: 2565 EAEEGVRRKQEELQQLEQQ-RRQQEELLAEENQRLREQLQLLE-EQHRAALAH 2615 Score = 46.2 bits (108), Expect = 6e-05 Identities = 98/393 (24%), Positives = 156/393 (39%), Gaps = 42/393 (10%) Query: 62 SLVDALLEQVARF-REQLRR--QEGGAAEAQMRQEIERLTE--RLEEKEREMQQLLSQPQ 116 S + L Q +F E LRR +E AE Q +E ERL E EK+R++ + +Q + Sbjct: 1328 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1387 Query: 117 HEREKEVVLLRRSMAEG----ERARAASDVLCRSLANETHQLRRTLTA-------TAHMC 165 + E+E L++ M E E A + RS+ E QLR++ A A Sbjct: 1388 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1447 Query: 166 QHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225 + ++E R E + Q +G +Q++ + +E +Q E L Sbjct: 1448 ERSRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRR 1505 Query: 226 KWQRYNASRDEYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAA 284 + Q DE R A++ ++ E E R E R + LEE E ++ L Sbjct: 1506 QVQ------DESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1558 Query: 285 SRTAR----DAALERVQ-MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339 + R ALE Q E ++ + + F + A ER+ +QE VA L + Sbjct: 1559 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAE 1615 Query: 340 WR-QDSREPDAGRIHAGSKTAKY--LAADALELMVPG---GWRPGTGSQQPEPPAEGGHP 393 R Q E + R A + ++ A +AL L + + + E E Sbjct: 1616 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1675 Query: 394 GAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAE 426 A +RG+ + Q Q EQ E R +AE Sbjct: 1676 EARRRGKAEEQAVR--QRELAEQELEKQRQLAE 1706 >gi|41322919 plectin 1 isoform 8 [Homo sapiens] Length = 4547 Score = 60.5 bits (145), Expect = 3e-09 Identities = 84/343 (24%), Positives = 141/343 (41%), Gaps = 50/343 (14%) Query: 11 EEAPRAAAALCTLYHEAGQRLR----RLQDQLAARDALIARLRARLAALEGDAAPSLVDA 66 E+A AA L E +R R R+Q LAA + + +A L +E + A Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER------LKA 2016 Query: 67 LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEE---------KEREMQQLLSQPQH 117 +E+ R RE R ++ A + Q+ QE + + EE KE+E+QQ L Q Q Sbjct: 2017 KVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074 Query: 118 EREK---EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE 174 ++ E RR+ E E AR ++ E Q RR + + Q + Sbjct: 2075 VLDQLRGEAEAARRAAEEAEEARVQAE-------REAAQSRRQVEEAERLKQSAEEQAQA 2127 Query: 175 RQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLN------AKWQ 228 R AQ E+ ++E Q + Q E L+QK ++ + Sbjct: 2128 RAQAQA-AAEKLRKEAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178 Query: 229 RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288 R A ++ + L QL + H+ L+ +E+ RL + E ++V++EL + R Sbjct: 2179 RQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236 Query: 289 RD--AALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEE 329 + + L+ E + L +D ++R +E A+ Q EE Sbjct: 2237 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279 Score = 57.8 bits (138), Expect = 2e-08 Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 43/360 (11%) Query: 29 QRLRRLQDQLAARDALIARLRARLAAL---EGDAAPSLVDALLEQVARFREQLRRQEGGA 85 + L ++ Q+ L AR+ A AL + D + E++ + E+ R A Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2287 Query: 86 AEA----QMRQEIERLTERLEEK--EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAA 139 EA Q+ +E L EK + +MQ + + + E E++ ++ +A+ + R Sbjct: 2288 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2347 Query: 140 SDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG-- 195 D + + LA ET +RTL A Q + E + + V E S Q+ + Sbjct: 2348 EDKEQMAQQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2404 Query: 196 --HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253 + + EKL ++KVT V+ L + Q Q H+ Sbjct: 2405 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------------QSDHD 2444 Query: 254 PELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR-DAALERVQMLEQQILAYKDDFMS 312 E +R+ I+ L R+ E+ + ++ + +T + + L+ Q L+Q L+ KD + Sbjct: 2445 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504 Query: 313 ERADRERAQSRIQELEE----KVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368 E+ ++++++L + K L + +Q E + R+ A + A+ +A E Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2564 Score = 51.6 bits (122), Expect = 1e-06 Identities = 86/341 (25%), Positives = 138/341 (40%), Gaps = 26/341 (7%) Query: 26 EAGQRLRR-LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84 E +RLRR +QD+ + L +R+ A E +AA AL + E+LR Q Sbjct: 1494 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRAL-----QALEELRLQ--- 1544 Query: 85 AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG----ERARAAS 140 A EA+ RL + E+ R++Q L Q E E+ R S AE ER+ Sbjct: 1545 AEEAE-----RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1599 Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV- 199 V L E + R A A + A+ ER + N R Q+E S+ Sbjct: 1600 HVAVAQLREEAER-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658 Query: 200 QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259 Q+ EK +EE ++ E+ + + E R L ++ E EL+R Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR- 1717 Query: 260 EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRER 319 L + E+ +++ELA + AA ++ Q LE ++ + + A + R Sbjct: 1718 ----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1773 Query: 320 AQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360 A+ + EK L + R +A R+ A ++ AK Sbjct: 1774 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814 Score = 50.8 bits (120), Expect = 2e-06 Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 32/300 (10%) Query: 27 AGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAA 86 A ++LR+ +Q AAR R +A AAL A DA +E+ +F EQ RQ+ Sbjct: 2134 AAEKLRKEAEQEAAR-----RAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---- 2181 Query: 87 EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRS 146 AQ+ QE+ L +LEE + + L ++E+ L+ E R R+ + S Sbjct: 2182 -AQVEQELTTLRLQLEETDHQKNLL--------DEELQRLKAEATEAARQRSQVEEELFS 2232 Query: 147 LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKL 206 + + +L + ++ A L ++ + QR + E + + + + ++ Sbjct: 2233 VRVQMEELSKLKARIE--AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2290 Query: 207 QEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNR 266 +L ++ + L K + + L A+ LQ + EL +++ RL Sbjct: 2291 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ--QQKELAQEQARRLQE 2348 Query: 267 QLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326 E+ + Q+LA LE + + ++ A + A+ RAQ+R +E Sbjct: 2349 DKEQ-------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2401 Score = 50.4 bits (119), Expect = 3e-06 Identities = 84/403 (20%), Positives = 165/403 (40%), Gaps = 32/403 (7%) Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85 EA +R + + + R+ L + EG A L A +++ R R + ++G Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAET--EQGEQ 1727 Query: 86 AEAQMRQEIERLTERLEEKEREMQQLLSQPQHER-EKEVVLLRRSMAEGERARAASDVLC 144 + +E+ RL ++ Q+L ++ R E EV+L ++ AE E +R+ S+ Sbjct: 1728 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE-EESRSTSEKSK 1786 Query: 145 RSLANETHQLR---------RTLTATAHMCQHLAK--CLDERQHAQRNVGERSPDQSEHT 193 + L E + R R L A + LA+ +R A+R + E+ E T Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846 Query: 194 DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253 T + +++ + EN L++ ED + +R ++ + +L L+ + Sbjct: 1847 RLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903 Query: 254 PELMR-----KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308 EL R ++ R RQ+EE+I ++ AA + + L R++ + L K+ Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963 Query: 309 DFMSE-------RADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKY 361 E A+ ER + +E +K + + + ++ + + R+ A + A+ Sbjct: 1964 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2023 Query: 362 LAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQ 404 L A + +Q+ E H A Q+ + +LQ Sbjct: 2024 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2066 Score = 49.3 bits (116), Expect = 7e-06 Identities = 75/329 (22%), Positives = 133/329 (40%), Gaps = 51/329 (15%) Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ---- 81 EA QR RRL++Q A A I A+L D+ L+E R R Q+ + Sbjct: 1873 EAFQR-RRLEEQAAQHKADIEERLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILAL 1930 Query: 82 -----EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERA 136 + A +A++ E+ R+ E+ R +Q E E R+ AE ER Sbjct: 1931 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA--------ELEAARQRQLAAEEERR 1982 Query: 137 RA-ASDVLCRSLANETHQLRRT---------LTATAHMCQHLAKCLDERQHAQRNVGERS 186 R A + + +SLA E R+ L A + L + ++ Q + + + Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2042 Query: 187 PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246 + + +V +K QE + L+Q+ + ++ L + + + +E A+ Sbjct: 2043 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEA 2096 Query: 247 GLQIPHEPELMRKEIS---RLNRQLEEKINDCA-----------EVKQELAASRTARDAA 292 +Q E R+++ RL + EE+ A E +QE A A AA Sbjct: 2097 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2156 Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQ 321 L + Q + ++ +K +E+ R++AQ Sbjct: 2157 LRQKQAADAEMEKHKK--FAEQTLRQKAQ 2183 Score = 47.4 bits (111), Expect = 3e-05 Identities = 89/393 (22%), Positives = 165/393 (41%), Gaps = 72/393 (18%) Query: 33 RLQDQLAARDALIARLRARLAAL---------EGDAAPSLVDALLEQVARFREQL----- 78 RLQ + RD + R R R+A L + D ++ L Q+ +RE Sbjct: 1162 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1221 Query: 79 ------RRQE---------GGAAEAQMRQE------IERLTERLEEKEREMQQLLSQPQH 117 RRQE A Q+RQE IER E++EE +R +Q ++ + Sbjct: 1222 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK- 1280 Query: 118 EREKEVVLLR------RSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKC 171 + E ++V + S A+ + ++ S+ + + + T T+ + +++ Sbjct: 1281 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1340 Query: 172 LDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK---LQEENRLLK-QKVTHVEDLNAKW 227 L + +R ++ ++ E V++ +EK L E + K Q ++L + Sbjct: 1341 LRRMEEEERLAEQQRAEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1397 Query: 228 QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287 Q R+E Q R +Q +E+ +L + E +I A+ +Q AA R+ Sbjct: 1398 QEEVVRREEAAVDAQQQKRSIQ---------EELQQLRQSSEAEIQ--AKARQAEAAERS 1446 Query: 288 ----ARDAALERVQM--LEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV--- 338 + + R+Q+ E+Q + + + RA E A+++ ++ +E+ L QV Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506 Query: 339 SWRQDSREPD-AGRIHAGSKTA--KYLAADALE 368 S R+ E + A R+ A ++ A K A ALE Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALE 1539 Score = 47.0 bits (110), Expect = 3e-05 Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 46/353 (13%) Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIAR--LRARLAAL-EGDAAPSLVDAL 67 EEA R + A + RLR+L ++ A+ +A L+ ++ A+ E + + L Sbjct: 2278 EEAARLSVAA-----QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2332 Query: 68 LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124 +Q +EQ RR ++++ E++ ++L E+ + Q+ L Q Q E E Sbjct: 2333 QQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2383 Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184 L+ +AE RA+A ++ + + ++ L T Q L + QR + Sbjct: 2384 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSD 2442 Query: 185 RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW--QRYNASRDEYVRGLH 242 D + ++ EKLQ+E +LL+ K ++ + + Q A + ++ Sbjct: 2443 H--DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2500 Query: 243 AQLRGLQIPHEP-----ELMRKEISRLNRQLEEKINDCAEVKQE----LAASRTAR---- 289 + L+ + + +L + E+++ + EE+ +++QE +A+ AR Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2560 Query: 290 ------DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336 E +Q LEQQ +++ ++E R R Q ++ E E+ A+L H Sbjct: 2561 EAEEGVRRKQEELQQLEQQ-RRQQEELLAEENQRLREQLQLLE-EQHRAALAH 2611 Score = 46.2 bits (108), Expect = 6e-05 Identities = 98/393 (24%), Positives = 156/393 (39%), Gaps = 42/393 (10%) Query: 62 SLVDALLEQVARF-REQLRR--QEGGAAEAQMRQEIERLTE--RLEEKEREMQQLLSQPQ 116 S + L Q +F E LRR +E AE Q +E ERL E EK+R++ + +Q + Sbjct: 1324 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1383 Query: 117 HEREKEVVLLRRSMAEG----ERARAASDVLCRSLANETHQLRRTLTA-------TAHMC 165 + E+E L++ M E E A + RS+ E QLR++ A A Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1443 Query: 166 QHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225 + ++E R E + Q +G +Q++ + +E +Q E L Sbjct: 1444 ERSRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRR 1501 Query: 226 KWQRYNASRDEYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAA 284 + Q DE R A++ ++ E E R E R + LEE E ++ L Sbjct: 1502 QVQ------DESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1554 Query: 285 SRTAR----DAALERVQ-MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339 + R ALE Q E ++ + + F + A ER+ +QE VA L + Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAE 1611 Query: 340 WR-QDSREPDAGRIHAGSKTAKY--LAADALELMVPG---GWRPGTGSQQPEPPAEGGHP 393 R Q E + R A + ++ A +AL L + + + E E Sbjct: 1612 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671 Query: 394 GAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAE 426 A +RG+ + Q Q EQ E R +AE Sbjct: 1672 EARRRGKAEEQAVR--QRELAEQELEKQRQLAE 1702 >gi|41322910 plectin 1 isoform 7 [Homo sapiens] Length = 4515 Score = 60.5 bits (145), Expect = 3e-09 Identities = 84/343 (24%), Positives = 141/343 (41%), Gaps = 50/343 (14%) Query: 11 EEAPRAAAALCTLYHEAGQRLR----RLQDQLAARDALIARLRARLAALEGDAAPSLVDA 66 E+A AA L E +R R R+Q LAA + + +A L +E + A Sbjct: 1931 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER------LKA 1984 Query: 67 LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEE---------KEREMQQLLSQPQH 117 +E+ R RE R ++ A + Q+ QE + + EE KE+E+QQ L Q Q Sbjct: 1985 KVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2042 Query: 118 EREK---EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE 174 ++ E RR+ E E AR ++ E Q RR + + Q + Sbjct: 2043 VLDQLRGEAEAARRAAEEAEEARVQAE-------REAAQSRRQVEEAERLKQSAEEQAQA 2095 Query: 175 RQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLN------AKWQ 228 R AQ E+ ++E Q + Q E L+QK ++ + Sbjct: 2096 RAQAQA-AAEKLRKEAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2146 Query: 229 RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288 R A ++ + L QL + H+ L+ +E+ RL + E ++V++EL + R Sbjct: 2147 RQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2204 Query: 289 RD--AALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEE 329 + + L+ E + L +D ++R +E A+ Q EE Sbjct: 2205 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2247 Score = 57.8 bits (138), Expect = 2e-08 Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 43/360 (11%) Query: 29 QRLRRLQDQLAARDALIARLRARLAAL---EGDAAPSLVDALLEQVARFREQLRRQEGGA 85 + L ++ Q+ L AR+ A AL + D + E++ + E+ R A Sbjct: 2196 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2255 Query: 86 AEA----QMRQEIERLTERLEEK--EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAA 139 EA Q+ +E L EK + +MQ + + + E E++ ++ +A+ + R Sbjct: 2256 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2315 Query: 140 SDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG-- 195 D + + LA ET +RTL A Q + E + + V E S Q+ + Sbjct: 2316 EDKEQMAQQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2372 Query: 196 --HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253 + + EKL ++KVT V+ L + Q Q H+ Sbjct: 2373 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------------QSDHD 2412 Query: 254 PELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR-DAALERVQMLEQQILAYKDDFMS 312 E +R+ I+ L R+ E+ + ++ + +T + + L+ Q L+Q L+ KD + Sbjct: 2413 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2472 Query: 313 ERADRERAQSRIQELEE----KVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368 E+ ++++++L + K L + +Q E + R+ A + A+ +A E Sbjct: 2473 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2532 Score = 51.6 bits (122), Expect = 1e-06 Identities = 86/341 (25%), Positives = 138/341 (40%), Gaps = 26/341 (7%) Query: 26 EAGQRLRR-LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84 E +RLRR +QD+ + L +R+ A E +AA AL + E+LR Q Sbjct: 1462 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRAL-----QALEELRLQ--- 1512 Query: 85 AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG----ERARAAS 140 A EA+ RL + E+ R++Q L Q E E+ R S AE ER+ Sbjct: 1513 AEEAE-----RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1567 Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV- 199 V L E + R A A + A+ ER + N R Q+E S+ Sbjct: 1568 HVAVAQLREEAER-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1626 Query: 200 QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259 Q+ EK +EE ++ E+ + + E R L ++ E EL+R Sbjct: 1627 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR- 1685 Query: 260 EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRER 319 L + E+ +++ELA + AA ++ Q LE ++ + + A + R Sbjct: 1686 ----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1741 Query: 320 AQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360 A+ + EK L + R +A R+ A ++ AK Sbjct: 1742 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1782 Score = 50.8 bits (120), Expect = 2e-06 Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 32/300 (10%) Query: 27 AGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAA 86 A ++LR+ +Q AAR R +A AAL A DA +E+ +F EQ RQ+ Sbjct: 2102 AAEKLRKEAEQEAAR-----RAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---- 2149 Query: 87 EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRS 146 AQ+ QE+ L +LEE + + L ++E+ L+ E R R+ + S Sbjct: 2150 -AQVEQELTTLRLQLEETDHQKNLL--------DEELQRLKAEATEAARQRSQVEEELFS 2200 Query: 147 LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKL 206 + + +L + ++ A L ++ + QR + E + + + + ++ Sbjct: 2201 VRVQMEELSKLKARIE--AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2258 Query: 207 QEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNR 266 +L ++ + L K + + L A+ LQ + EL +++ RL Sbjct: 2259 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ--QQKELAQEQARRLQE 2316 Query: 267 QLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326 E+ + Q+LA LE + + ++ A + A+ RAQ+R +E Sbjct: 2317 DKEQ-------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2369 Score = 50.4 bits (119), Expect = 3e-06 Identities = 84/403 (20%), Positives = 165/403 (40%), Gaps = 32/403 (7%) Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85 EA +R + + + R+ L + EG A L A +++ R R + ++G Sbjct: 1640 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAET--EQGEQ 1695 Query: 86 AEAQMRQEIERLTERLEEKEREMQQLLSQPQHER-EKEVVLLRRSMAEGERARAASDVLC 144 + +E+ RL ++ Q+L ++ R E EV+L ++ AE E +R+ S+ Sbjct: 1696 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE-EESRSTSEKSK 1754 Query: 145 RSLANETHQLR---------RTLTATAHMCQHLAK--CLDERQHAQRNVGERSPDQSEHT 193 + L E + R R L A + LA+ +R A+R + E+ E T Sbjct: 1755 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1814 Query: 194 DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253 T + +++ + EN L++ ED + +R ++ + +L L+ + Sbjct: 1815 RLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1871 Query: 254 PELMR-----KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308 EL R ++ R RQ+EE+I ++ AA + + L R++ + L K+ Sbjct: 1872 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1931 Query: 309 DFMSE-------RADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKY 361 E A+ ER + +E +K + + + ++ + + R+ A + A+ Sbjct: 1932 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 1991 Query: 362 LAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQ 404 L A + +Q+ E H A Q+ + +LQ Sbjct: 1992 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2034 Score = 49.3 bits (116), Expect = 7e-06 Identities = 75/329 (22%), Positives = 133/329 (40%), Gaps = 51/329 (15%) Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ---- 81 EA QR RRL++Q A A I A+L D+ L+E R R Q+ + Sbjct: 1841 EAFQR-RRLEEQAAQHKADIEERLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILAL 1898 Query: 82 -----EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERA 136 + A +A++ E+ R+ E+ R +Q E E R+ AE ER Sbjct: 1899 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA--------ELEAARQRQLAAEEERR 1950 Query: 137 RA-ASDVLCRSLANETHQLRRT---------LTATAHMCQHLAKCLDERQHAQRNVGERS 186 R A + + +SLA E R+ L A + L + ++ Q + + + Sbjct: 1951 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2010 Query: 187 PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246 + + +V +K QE + L+Q+ + ++ L + + + +E A+ Sbjct: 2011 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEA 2064 Query: 247 GLQIPHEPELMRKEIS---RLNRQLEEKINDCA-----------EVKQELAASRTARDAA 292 +Q E R+++ RL + EE+ A E +QE A A AA Sbjct: 2065 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2124 Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQ 321 L + Q + ++ +K +E+ R++AQ Sbjct: 2125 LRQKQAADAEMEKHKK--FAEQTLRQKAQ 2151 Score = 47.4 bits (111), Expect = 3e-05 Identities = 89/393 (22%), Positives = 165/393 (41%), Gaps = 72/393 (18%) Query: 33 RLQDQLAARDALIARLRARLAAL---------EGDAAPSLVDALLEQVARFREQL----- 78 RLQ + RD + R R R+A L + D ++ L Q+ +RE Sbjct: 1130 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1189 Query: 79 ------RRQE---------GGAAEAQMRQE------IERLTERLEEKEREMQQLLSQPQH 117 RRQE A Q+RQE IER E++EE +R +Q ++ + Sbjct: 1190 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK- 1248 Query: 118 EREKEVVLLR------RSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKC 171 + E ++V + S A+ + ++ S+ + + + T T+ + +++ Sbjct: 1249 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1308 Query: 172 LDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK---LQEENRLLK-QKVTHVEDLNAKW 227 L + +R ++ ++ E V++ +EK L E + K Q ++L + Sbjct: 1309 LRRMEEEERLAEQQRAEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1365 Query: 228 QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287 Q R+E Q R +Q +E+ +L + E +I A+ +Q AA R+ Sbjct: 1366 QEEVVRREEAAVDAQQQKRSIQ---------EELQQLRQSSEAEIQ--AKARQAEAAERS 1414 Query: 288 ----ARDAALERVQM--LEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV--- 338 + + R+Q+ E+Q + + + RA E A+++ ++ +E+ L QV Sbjct: 1415 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1474 Query: 339 SWRQDSREPD-AGRIHAGSKTA--KYLAADALE 368 S R+ E + A R+ A ++ A K A ALE Sbjct: 1475 SQRKRQAEVELASRVKAEAEAAREKQRALQALE 1507 Score = 47.0 bits (110), Expect = 3e-05 Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 46/353 (13%) Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIAR--LRARLAAL-EGDAAPSLVDAL 67 EEA R + A + RLR+L ++ A+ +A L+ ++ A+ E + + L Sbjct: 2246 EEAARLSVAA-----QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2300 Query: 68 LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124 +Q +EQ RR ++++ E++ ++L E+ + Q+ L Q Q E E Sbjct: 2301 QQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2351 Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184 L+ +AE RA+A ++ + + ++ L T Q L + QR + Sbjct: 2352 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSD 2410 Query: 185 RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW--QRYNASRDEYVRGLH 242 D + ++ EKLQ+E +LL+ K ++ + + Q A + ++ Sbjct: 2411 H--DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2468 Query: 243 AQLRGLQIPHEP-----ELMRKEISRLNRQLEEKINDCAEVKQE----LAASRTAR---- 289 + L+ + + +L + E+++ + EE+ +++QE +A+ AR Sbjct: 2469 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2528 Query: 290 ------DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336 E +Q LEQQ +++ ++E R R Q ++ E E+ A+L H Sbjct: 2529 EAEEGVRRKQEELQQLEQQ-RRQQEELLAEENQRLREQLQLLE-EQHRAALAH 2579 Score = 46.2 bits (108), Expect = 6e-05 Identities = 98/393 (24%), Positives = 156/393 (39%), Gaps = 42/393 (10%) Query: 62 SLVDALLEQVARF-REQLRR--QEGGAAEAQMRQEIERLTE--RLEEKEREMQQLLSQPQ 116 S + L Q +F E LRR +E AE Q +E ERL E EK+R++ + +Q + Sbjct: 1292 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1351 Query: 117 HEREKEVVLLRRSMAEG----ERARAASDVLCRSLANETHQLRRTLTA-------TAHMC 165 + E+E L++ M E E A + RS+ E QLR++ A A Sbjct: 1352 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1411 Query: 166 QHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225 + ++E R E + Q +G +Q++ + +E +Q E L Sbjct: 1412 ERSRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRR 1469 Query: 226 KWQRYNASRDEYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAA 284 + Q DE R A++ ++ E E R E R + LEE E ++ L Sbjct: 1470 QVQ------DESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1522 Query: 285 SRTAR----DAALERVQ-MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339 + R ALE Q E ++ + + F + A ER+ +QE VA L + Sbjct: 1523 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAE 1579 Query: 340 WR-QDSREPDAGRIHAGSKTAKY--LAADALELMVPG---GWRPGTGSQQPEPPAEGGHP 393 R Q E + R A + ++ A +AL L + + + E E Sbjct: 1580 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1639 Query: 394 GAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAE 426 A +RG+ + Q Q EQ E R +AE Sbjct: 1640 EARRRGKAEEQAVR--QRELAEQELEKQRQLAE 1670 >gi|41322916 plectin 1 isoform 6 [Homo sapiens] Length = 4684 Score = 60.5 bits (145), Expect = 3e-09 Identities = 84/343 (24%), Positives = 141/343 (41%), Gaps = 50/343 (14%) Query: 11 EEAPRAAAALCTLYHEAGQRLR----RLQDQLAARDALIARLRARLAALEGDAAPSLVDA 66 E+A AA L E +R R R+Q LAA + + +A L +E + A Sbjct: 2100 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER------LKA 2153 Query: 67 LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEE---------KEREMQQLLSQPQH 117 +E+ R RE R ++ A + Q+ QE + + EE KE+E+QQ L Q Q Sbjct: 2154 KVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2211 Query: 118 EREK---EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE 174 ++ E RR+ E E AR ++ E Q RR + + Q + Sbjct: 2212 VLDQLRGEAEAARRAAEEAEEARVQAE-------REAAQSRRQVEEAERLKQSAEEQAQA 2264 Query: 175 RQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLN------AKWQ 228 R AQ E+ ++E Q + Q E L+QK ++ + Sbjct: 2265 RAQAQA-AAEKLRKEAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2315 Query: 229 RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288 R A ++ + L QL + H+ L+ +E+ RL + E ++V++EL + R Sbjct: 2316 RQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2373 Query: 289 RD--AALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEE 329 + + L+ E + L +D ++R +E A+ Q EE Sbjct: 2374 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2416 Score = 57.8 bits (138), Expect = 2e-08 Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 43/360 (11%) Query: 29 QRLRRLQDQLAARDALIARLRARLAAL---EGDAAPSLVDALLEQVARFREQLRRQEGGA 85 + L ++ Q+ L AR+ A AL + D + E++ + E+ R A Sbjct: 2365 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2424 Query: 86 AEA----QMRQEIERLTERLEEK--EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAA 139 EA Q+ +E L EK + +MQ + + + E E++ ++ +A+ + R Sbjct: 2425 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2484 Query: 140 SDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG-- 195 D + + LA ET +RTL A Q + E + + V E S Q+ + Sbjct: 2485 EDKEQMAQQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2541 Query: 196 --HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253 + + EKL ++KVT V+ L + Q Q H+ Sbjct: 2542 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------------QSDHD 2581 Query: 254 PELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR-DAALERVQMLEQQILAYKDDFMS 312 E +R+ I+ L R+ E+ + ++ + +T + + L+ Q L+Q L+ KD + Sbjct: 2582 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2641 Query: 313 ERADRERAQSRIQELEE----KVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368 E+ ++++++L + K L + +Q E + R+ A + A+ +A E Sbjct: 2642 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2701 Score = 51.6 bits (122), Expect = 1e-06 Identities = 86/341 (25%), Positives = 138/341 (40%), Gaps = 26/341 (7%) Query: 26 EAGQRLRR-LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84 E +RLRR +QD+ + L +R+ A E +AA AL + E+LR Q Sbjct: 1631 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRAL-----QALEELRLQ--- 1681 Query: 85 AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG----ERARAAS 140 A EA+ RL + E+ R++Q L Q E E+ R S AE ER+ Sbjct: 1682 AEEAE-----RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1736 Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV- 199 V L E + R A A + A+ ER + N R Q+E S+ Sbjct: 1737 HVAVAQLREEAER-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1795 Query: 200 QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259 Q+ EK +EE ++ E+ + + E R L ++ E EL+R Sbjct: 1796 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR- 1854 Query: 260 EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRER 319 L + E+ +++ELA + AA ++ Q LE ++ + + A + R Sbjct: 1855 ----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1910 Query: 320 AQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360 A+ + EK L + R +A R+ A ++ AK Sbjct: 1911 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1951 Score = 50.8 bits (120), Expect = 2e-06 Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 32/300 (10%) Query: 27 AGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAA 86 A ++LR+ +Q AAR R +A AAL A DA +E+ +F EQ RQ+ Sbjct: 2271 AAEKLRKEAEQEAAR-----RAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---- 2318 Query: 87 EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRS 146 AQ+ QE+ L +LEE + + L ++E+ L+ E R R+ + S Sbjct: 2319 -AQVEQELTTLRLQLEETDHQKNLL--------DEELQRLKAEATEAARQRSQVEEELFS 2369 Query: 147 LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKL 206 + + +L + ++ A L ++ + QR + E + + + + ++ Sbjct: 2370 VRVQMEELSKLKARIE--AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2427 Query: 207 QEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNR 266 +L ++ + L K + + L A+ LQ + EL +++ RL Sbjct: 2428 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ--QQKELAQEQARRLQE 2485 Query: 267 QLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326 E+ + Q+LA LE + + ++ A + A+ RAQ+R +E Sbjct: 2486 DKEQ-------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2538 Score = 50.4 bits (119), Expect = 3e-06 Identities = 84/403 (20%), Positives = 165/403 (40%), Gaps = 32/403 (7%) Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85 EA +R + + + R+ L + EG A L A +++ R R + ++G Sbjct: 1809 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAET--EQGEQ 1864 Query: 86 AEAQMRQEIERLTERLEEKEREMQQLLSQPQHER-EKEVVLLRRSMAEGERARAASDVLC 144 + +E+ RL ++ Q+L ++ R E EV+L ++ AE E +R+ S+ Sbjct: 1865 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE-EESRSTSEKSK 1923 Query: 145 RSLANETHQLR---------RTLTATAHMCQHLAK--CLDERQHAQRNVGERSPDQSEHT 193 + L E + R R L A + LA+ +R A+R + E+ E T Sbjct: 1924 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1983 Query: 194 DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253 T + +++ + EN L++ ED + +R ++ + +L L+ + Sbjct: 1984 RLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 2040 Query: 254 PELMR-----KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308 EL R ++ R RQ+EE+I ++ AA + + L R++ + L K+ Sbjct: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 2100 Query: 309 DFMSE-------RADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKY 361 E A+ ER + +E +K + + + ++ + + R+ A + A+ Sbjct: 2101 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2160 Query: 362 LAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQ 404 L A + +Q+ E H A Q+ + +LQ Sbjct: 2161 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2203 Score = 49.3 bits (116), Expect = 7e-06 Identities = 75/329 (22%), Positives = 133/329 (40%), Gaps = 51/329 (15%) Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ---- 81 EA QR RRL++Q A A I A+L D+ L+E R R Q+ + Sbjct: 2010 EAFQR-RRLEEQAAQHKADIEERLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILAL 2067 Query: 82 -----EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERA 136 + A +A++ E+ R+ E+ R +Q E E R+ AE ER Sbjct: 2068 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA--------ELEAARQRQLAAEEERR 2119 Query: 137 RA-ASDVLCRSLANETHQLRRT---------LTATAHMCQHLAKCLDERQHAQRNVGERS 186 R A + + +SLA E R+ L A + L + ++ Q + + + Sbjct: 2120 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2179 Query: 187 PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246 + + +V +K QE + L+Q+ + ++ L + + + +E A+ Sbjct: 2180 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEA 2233 Query: 247 GLQIPHEPELMRKEIS---RLNRQLEEKINDCA-----------EVKQELAASRTARDAA 292 +Q E R+++ RL + EE+ A E +QE A A AA Sbjct: 2234 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2293 Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQ 321 L + Q + ++ +K +E+ R++AQ Sbjct: 2294 LRQKQAADAEMEKHKK--FAEQTLRQKAQ 2320 Score = 47.4 bits (111), Expect = 3e-05 Identities = 89/393 (22%), Positives = 165/393 (41%), Gaps = 72/393 (18%) Query: 33 RLQDQLAARDALIARLRARLAAL---------EGDAAPSLVDALLEQVARFREQL----- 78 RLQ + RD + R R R+A L + D ++ L Q+ +RE Sbjct: 1299 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1358 Query: 79 ------RRQE---------GGAAEAQMRQE------IERLTERLEEKEREMQQLLSQPQH 117 RRQE A Q+RQE IER E++EE +R +Q ++ + Sbjct: 1359 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK- 1417 Query: 118 EREKEVVLLR------RSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKC 171 + E ++V + S A+ + ++ S+ + + + T T+ + +++ Sbjct: 1418 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1477 Query: 172 LDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK---LQEENRLLK-QKVTHVEDLNAKW 227 L + +R ++ ++ E V++ +EK L E + K Q ++L + Sbjct: 1478 LRRMEEEERLAEQQRAEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1534 Query: 228 QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287 Q R+E Q R +Q +E+ +L + E +I A+ +Q AA R+ Sbjct: 1535 QEEVVRREEAAVDAQQQKRSIQ---------EELQQLRQSSEAEIQ--AKARQAEAAERS 1583 Query: 288 ----ARDAALERVQM--LEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV--- 338 + + R+Q+ E+Q + + + RA E A+++ ++ +E+ L QV Sbjct: 1584 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1643 Query: 339 SWRQDSREPD-AGRIHAGSKTA--KYLAADALE 368 S R+ E + A R+ A ++ A K A ALE Sbjct: 1644 SQRKRQAEVELASRVKAEAEAAREKQRALQALE 1676 Score = 47.0 bits (110), Expect = 3e-05 Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 46/353 (13%) Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIAR--LRARLAAL-EGDAAPSLVDAL 67 EEA R + A + RLR+L ++ A+ +A L+ ++ A+ E + + L Sbjct: 2415 EEAARLSVAA-----QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2469 Query: 68 LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124 +Q +EQ RR ++++ E++ ++L E+ + Q+ L Q Q E E Sbjct: 2470 QQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2520 Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184 L+ +AE RA+A ++ + + ++ L T Q L + QR + Sbjct: 2521 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSD 2579 Query: 185 RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW--QRYNASRDEYVRGLH 242 D + ++ EKLQ+E +LL+ K ++ + + Q A + ++ Sbjct: 2580 H--DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2637 Query: 243 AQLRGLQIPHEP-----ELMRKEISRLNRQLEEKINDCAEVKQE----LAASRTAR---- 289 + L+ + + +L + E+++ + EE+ +++QE +A+ AR Sbjct: 2638 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2697 Query: 290 ------DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336 E +Q LEQQ +++ ++E R R Q ++ E E+ A+L H Sbjct: 2698 EAEEGVRRKQEELQQLEQQ-RRQQEELLAEENQRLREQLQLLE-EQHRAALAH 2748 Score = 46.2 bits (108), Expect = 6e-05 Identities = 98/393 (24%), Positives = 156/393 (39%), Gaps = 42/393 (10%) Query: 62 SLVDALLEQVARF-REQLRR--QEGGAAEAQMRQEIERLTE--RLEEKEREMQQLLSQPQ 116 S + L Q +F E LRR +E AE Q +E ERL E EK+R++ + +Q + Sbjct: 1461 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1520 Query: 117 HEREKEVVLLRRSMAEG----ERARAASDVLCRSLANETHQLRRTLTA-------TAHMC 165 + E+E L++ M E E A + RS+ E QLR++ A A Sbjct: 1521 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1580 Query: 166 QHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225 + ++E R E + Q +G +Q++ + +E +Q E L Sbjct: 1581 ERSRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRR 1638 Query: 226 KWQRYNASRDEYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAA 284 + Q DE R A++ ++ E E R E R + LEE E ++ L Sbjct: 1639 QVQ------DESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1691 Query: 285 SRTAR----DAALERVQ-MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339 + R ALE Q E ++ + + F + A ER+ +QE VA L + Sbjct: 1692 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAE 1748 Query: 340 WR-QDSREPDAGRIHAGSKTAKY--LAADALELMVPG---GWRPGTGSQQPEPPAEGGHP 393 R Q E + R A + ++ A +AL L + + + E E Sbjct: 1749 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1808 Query: 394 GAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAE 426 A +RG+ + Q Q EQ E R +AE Sbjct: 1809 EARRRGKAEEQAVR--QRELAEQELEKQRQLAE 1839 >gi|41322908 plectin 1 isoform 3 [Homo sapiens] Length = 4525 Score = 60.5 bits (145), Expect = 3e-09 Identities = 84/343 (24%), Positives = 141/343 (41%), Gaps = 50/343 (14%) Query: 11 EEAPRAAAALCTLYHEAGQRLR----RLQDQLAARDALIARLRARLAALEGDAAPSLVDA 66 E+A AA L E +R R R+Q LAA + + +A L +E + A Sbjct: 1941 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER------LKA 1994 Query: 67 LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEE---------KEREMQQLLSQPQH 117 +E+ R RE R ++ A + Q+ QE + + EE KE+E+QQ L Q Q Sbjct: 1995 KVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2052 Query: 118 EREK---EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE 174 ++ E RR+ E E AR ++ E Q RR + + Q + Sbjct: 2053 VLDQLRGEAEAARRAAEEAEEARVQAE-------REAAQSRRQVEEAERLKQSAEEQAQA 2105 Query: 175 RQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLN------AKWQ 228 R AQ E+ ++E Q + Q E L+QK ++ + Sbjct: 2106 RAQAQA-AAEKLRKEAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2156 Query: 229 RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288 R A ++ + L QL + H+ L+ +E+ RL + E ++V++EL + R Sbjct: 2157 RQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2214 Query: 289 RD--AALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEE 329 + + L+ E + L +D ++R +E A+ Q EE Sbjct: 2215 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2257 Score = 57.8 bits (138), Expect = 2e-08 Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 43/360 (11%) Query: 29 QRLRRLQDQLAARDALIARLRARLAAL---EGDAAPSLVDALLEQVARFREQLRRQEGGA 85 + L ++ Q+ L AR+ A AL + D + E++ + E+ R A Sbjct: 2206 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2265 Query: 86 AEA----QMRQEIERLTERLEEK--EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAA 139 EA Q+ +E L EK + +MQ + + + E E++ ++ +A+ + R Sbjct: 2266 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2325 Query: 140 SDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG-- 195 D + + LA ET +RTL A Q + E + + V E S Q+ + Sbjct: 2326 EDKEQMAQQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2382 Query: 196 --HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253 + + EKL ++KVT V+ L + Q Q H+ Sbjct: 2383 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------------QSDHD 2422 Query: 254 PELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR-DAALERVQMLEQQILAYKDDFMS 312 E +R+ I+ L R+ E+ + ++ + +T + + L+ Q L+Q L+ KD + Sbjct: 2423 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2482 Query: 313 ERADRERAQSRIQELEE----KVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368 E+ ++++++L + K L + +Q E + R+ A + A+ +A E Sbjct: 2483 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2542 Score = 51.6 bits (122), Expect = 1e-06 Identities = 86/341 (25%), Positives = 138/341 (40%), Gaps = 26/341 (7%) Query: 26 EAGQRLRR-LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84 E +RLRR +QD+ + L +R+ A E +AA AL + E+LR Q Sbjct: 1472 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRAL-----QALEELRLQ--- 1522 Query: 85 AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG----ERARAAS 140 A EA+ RL + E+ R++Q L Q E E+ R S AE ER+ Sbjct: 1523 AEEAE-----RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1577 Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV- 199 V L E + R A A + A+ ER + N R Q+E S+ Sbjct: 1578 HVAVAQLREEAER-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1636 Query: 200 QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259 Q+ EK +EE ++ E+ + + E R L ++ E EL+R Sbjct: 1637 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR- 1695 Query: 260 EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRER 319 L + E+ +++ELA + AA ++ Q LE ++ + + A + R Sbjct: 1696 ----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1751 Query: 320 AQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360 A+ + EK L + R +A R+ A ++ AK Sbjct: 1752 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1792 Score = 50.8 bits (120), Expect = 2e-06 Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 32/300 (10%) Query: 27 AGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAA 86 A ++LR+ +Q AAR R +A AAL A DA +E+ +F EQ RQ+ Sbjct: 2112 AAEKLRKEAEQEAAR-----RAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---- 2159 Query: 87 EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRS 146 AQ+ QE+ L +LEE + + L ++E+ L+ E R R+ + S Sbjct: 2160 -AQVEQELTTLRLQLEETDHQKNLL--------DEELQRLKAEATEAARQRSQVEEELFS 2210 Query: 147 LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKL 206 + + +L + ++ A L ++ + QR + E + + + + ++ Sbjct: 2211 VRVQMEELSKLKARIE--AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2268 Query: 207 QEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNR 266 +L ++ + L K + + L A+ LQ + EL +++ RL Sbjct: 2269 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ--QQKELAQEQARRLQE 2326 Query: 267 QLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326 E+ + Q+LA LE + + ++ A + A+ RAQ+R +E Sbjct: 2327 DKEQ-------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2379 Score = 50.4 bits (119), Expect = 3e-06 Identities = 84/403 (20%), Positives = 165/403 (40%), Gaps = 32/403 (7%) Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85 EA +R + + + R+ L + EG A L A +++ R R + ++G Sbjct: 1650 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAET--EQGEQ 1705 Query: 86 AEAQMRQEIERLTERLEEKEREMQQLLSQPQHER-EKEVVLLRRSMAEGERARAASDVLC 144 + +E+ RL ++ Q+L ++ R E EV+L ++ AE E +R+ S+ Sbjct: 1706 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE-EESRSTSEKSK 1764 Query: 145 RSLANETHQLR---------RTLTATAHMCQHLAK--CLDERQHAQRNVGERSPDQSEHT 193 + L E + R R L A + LA+ +R A+R + E+ E T Sbjct: 1765 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1824 Query: 194 DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253 T + +++ + EN L++ ED + +R ++ + +L L+ + Sbjct: 1825 RLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1881 Query: 254 PELMR-----KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308 EL R ++ R RQ+EE+I ++ AA + + L R++ + L K+ Sbjct: 1882 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1941 Query: 309 DFMSE-------RADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKY 361 E A+ ER + +E +K + + + ++ + + R+ A + A+ Sbjct: 1942 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2001 Query: 362 LAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQ 404 L A + +Q+ E H A Q+ + +LQ Sbjct: 2002 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2044 Score = 49.3 bits (116), Expect = 7e-06 Identities = 75/329 (22%), Positives = 133/329 (40%), Gaps = 51/329 (15%) Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ---- 81 EA QR RRL++Q A A I A+L D+ L+E R R Q+ + Sbjct: 1851 EAFQR-RRLEEQAAQHKADIEERLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILAL 1908 Query: 82 -----EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERA 136 + A +A++ E+ R+ E+ R +Q E E R+ AE ER Sbjct: 1909 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA--------ELEAARQRQLAAEEERR 1960 Query: 137 RA-ASDVLCRSLANETHQLRRT---------LTATAHMCQHLAKCLDERQHAQRNVGERS 186 R A + + +SLA E R+ L A + L + ++ Q + + + Sbjct: 1961 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2020 Query: 187 PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246 + + +V +K QE + L+Q+ + ++ L + + + +E A+ Sbjct: 2021 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEA 2074 Query: 247 GLQIPHEPELMRKEIS---RLNRQLEEKINDCA-----------EVKQELAASRTARDAA 292 +Q E R+++ RL + EE+ A E +QE A A AA Sbjct: 2075 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2134 Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQ 321 L + Q + ++ +K +E+ R++AQ Sbjct: 2135 LRQKQAADAEMEKHKK--FAEQTLRQKAQ 2161 Score = 47.4 bits (111), Expect = 3e-05 Identities = 89/393 (22%), Positives = 165/393 (41%), Gaps = 72/393 (18%) Query: 33 RLQDQLAARDALIARLRARLAAL---------EGDAAPSLVDALLEQVARFREQL----- 78 RLQ + RD + R R R+A L + D ++ L Q+ +RE Sbjct: 1140 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1199 Query: 79 ------RRQE---------GGAAEAQMRQE------IERLTERLEEKEREMQQLLSQPQH 117 RRQE A Q+RQE IER E++EE +R +Q ++ + Sbjct: 1200 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK- 1258 Query: 118 EREKEVVLLR------RSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKC 171 + E ++V + S A+ + ++ S+ + + + T T+ + +++ Sbjct: 1259 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1318 Query: 172 LDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK---LQEENRLLK-QKVTHVEDLNAKW 227 L + +R ++ ++ E V++ +EK L E + K Q ++L + Sbjct: 1319 LRRMEEEERLAEQQRAEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1375 Query: 228 QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287 Q R+E Q R +Q +E+ +L + E +I A+ +Q AA R+ Sbjct: 1376 QEEVVRREEAAVDAQQQKRSIQ---------EELQQLRQSSEAEIQ--AKARQAEAAERS 1424 Query: 288 ----ARDAALERVQM--LEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV--- 338 + + R+Q+ E+Q + + + RA E A+++ ++ +E+ L QV Sbjct: 1425 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1484 Query: 339 SWRQDSREPD-AGRIHAGSKTA--KYLAADALE 368 S R+ E + A R+ A ++ A K A ALE Sbjct: 1485 SQRKRQAEVELASRVKAEAEAAREKQRALQALE 1517 Score = 47.0 bits (110), Expect = 3e-05 Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 46/353 (13%) Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIAR--LRARLAAL-EGDAAPSLVDAL 67 EEA R + A + RLR+L ++ A+ +A L+ ++ A+ E + + L Sbjct: 2256 EEAARLSVAA-----QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2310 Query: 68 LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124 +Q +EQ RR ++++ E++ ++L E+ + Q+ L Q Q E E Sbjct: 2311 QQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2361 Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184 L+ +AE RA+A ++ + + ++ L T Q L + QR + Sbjct: 2362 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSD 2420 Query: 185 RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW--QRYNASRDEYVRGLH 242 D + ++ EKLQ+E +LL+ K ++ + + Q A + ++ Sbjct: 2421 H--DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2478 Query: 243 AQLRGLQIPHEP-----ELMRKEISRLNRQLEEKINDCAEVKQE----LAASRTAR---- 289 + L+ + + +L + E+++ + EE+ +++QE +A+ AR Sbjct: 2479 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2538 Query: 290 ------DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336 E +Q LEQQ +++ ++E R R Q ++ E E+ A+L H Sbjct: 2539 EAEEGVRRKQEELQQLEQQ-RRQQEELLAEENQRLREQLQLLE-EQHRAALAH 2589 Score = 46.2 bits (108), Expect = 6e-05 Identities = 98/393 (24%), Positives = 156/393 (39%), Gaps = 42/393 (10%) Query: 62 SLVDALLEQVARF-REQLRR--QEGGAAEAQMRQEIERLTE--RLEEKEREMQQLLSQPQ 116 S + L Q +F E LRR +E AE Q +E ERL E EK+R++ + +Q + Sbjct: 1302 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1361 Query: 117 HEREKEVVLLRRSMAEG----ERARAASDVLCRSLANETHQLRRTLTA-------TAHMC 165 + E+E L++ M E E A + RS+ E QLR++ A A Sbjct: 1362 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1421 Query: 166 QHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225 + ++E R E + Q +G +Q++ + +E +Q E L Sbjct: 1422 ERSRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRR 1479 Query: 226 KWQRYNASRDEYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAA 284 + Q DE R A++ ++ E E R E R + LEE E ++ L Sbjct: 1480 QVQ------DESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1532 Query: 285 SRTAR----DAALERVQ-MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339 + R ALE Q E ++ + + F + A ER+ +QE VA L + Sbjct: 1533 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAE 1589 Query: 340 WR-QDSREPDAGRIHAGSKTAKY--LAADALELMVPG---GWRPGTGSQQPEPPAEGGHP 393 R Q E + R A + ++ A +AL L + + + E E Sbjct: 1590 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1649 Query: 394 GAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAE 426 A +RG+ + Q Q EQ E R +AE Sbjct: 1650 EARRRGKAEEQAVR--QRELAEQELEKQRQLAE 1680 >gi|41322912 plectin 1 isoform 2 [Homo sapiens] Length = 4533 Score = 60.5 bits (145), Expect = 3e-09 Identities = 84/343 (24%), Positives = 141/343 (41%), Gaps = 50/343 (14%) Query: 11 EEAPRAAAALCTLYHEAGQRLR----RLQDQLAARDALIARLRARLAALEGDAAPSLVDA 66 E+A AA L E +R R R+Q LAA + + +A L +E + A Sbjct: 1949 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER------LKA 2002 Query: 67 LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEE---------KEREMQQLLSQPQH 117 +E+ R RE R ++ A + Q+ QE + + EE KE+E+QQ L Q Q Sbjct: 2003 KVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2060 Query: 118 EREK---EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE 174 ++ E RR+ E E AR ++ E Q RR + + Q + Sbjct: 2061 VLDQLRGEAEAARRAAEEAEEARVQAE-------REAAQSRRQVEEAERLKQSAEEQAQA 2113 Query: 175 RQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLN------AKWQ 228 R AQ E+ ++E Q + Q E L+QK ++ + Sbjct: 2114 RAQAQA-AAEKLRKEAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2164 Query: 229 RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288 R A ++ + L QL + H+ L+ +E+ RL + E ++V++EL + R Sbjct: 2165 RQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2222 Query: 289 RD--AALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEE 329 + + L+ E + L +D ++R +E A+ Q EE Sbjct: 2223 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2265 Score = 57.8 bits (138), Expect = 2e-08 Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 43/360 (11%) Query: 29 QRLRRLQDQLAARDALIARLRARLAAL---EGDAAPSLVDALLEQVARFREQLRRQEGGA 85 + L ++ Q+ L AR+ A AL + D + E++ + E+ R A Sbjct: 2214 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2273 Query: 86 AEA----QMRQEIERLTERLEEK--EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAA 139 EA Q+ +E L EK + +MQ + + + E E++ ++ +A+ + R Sbjct: 2274 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2333 Query: 140 SDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG-- 195 D + + LA ET +RTL A Q + E + + V E S Q+ + Sbjct: 2334 EDKEQMAQQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2390 Query: 196 --HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253 + + EKL ++KVT V+ L + Q Q H+ Sbjct: 2391 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------------QSDHD 2430 Query: 254 PELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR-DAALERVQMLEQQILAYKDDFMS 312 E +R+ I+ L R+ E+ + ++ + +T + + L+ Q L+Q L+ KD + Sbjct: 2431 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2490 Query: 313 ERADRERAQSRIQELEE----KVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368 E+ ++++++L + K L + +Q E + R+ A + A+ +A E Sbjct: 2491 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2550 Score = 51.6 bits (122), Expect = 1e-06 Identities = 86/341 (25%), Positives = 138/341 (40%), Gaps = 26/341 (7%) Query: 26 EAGQRLRR-LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84 E +RLRR +QD+ + L +R+ A E +AA AL + E+LR Q Sbjct: 1480 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRAL-----QALEELRLQ--- 1530 Query: 85 AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG----ERARAAS 140 A EA+ RL + E+ R++Q L Q E E+ R S AE ER+ Sbjct: 1531 AEEAE-----RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1585 Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV- 199 V L E + R A A + A+ ER + N R Q+E S+ Sbjct: 1586 HVAVAQLREEAER-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1644 Query: 200 QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259 Q+ EK +EE ++ E+ + + E R L ++ E EL+R Sbjct: 1645 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR- 1703 Query: 260 EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRER 319 L + E+ +++ELA + AA ++ Q LE ++ + + A + R Sbjct: 1704 ----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1759 Query: 320 AQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360 A+ + EK L + R +A R+ A ++ AK Sbjct: 1760 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1800 Score = 50.8 bits (120), Expect = 2e-06 Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 32/300 (10%) Query: 27 AGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAA 86 A ++LR+ +Q AAR R +A AAL A DA +E+ +F EQ RQ+ Sbjct: 2120 AAEKLRKEAEQEAAR-----RAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---- 2167 Query: 87 EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRS 146 AQ+ QE+ L +LEE + + L ++E+ L+ E R R+ + S Sbjct: 2168 -AQVEQELTTLRLQLEETDHQKNLL--------DEELQRLKAEATEAARQRSQVEEELFS 2218 Query: 147 LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKL 206 + + +L + ++ A L ++ + QR + E + + + + ++ Sbjct: 2219 VRVQMEELSKLKARIE--AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2276 Query: 207 QEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNR 266 +L ++ + L K + + L A+ LQ + EL +++ RL Sbjct: 2277 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ--QQKELAQEQARRLQE 2334 Query: 267 QLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326 E+ + Q+LA LE + + ++ A + A+ RAQ+R +E Sbjct: 2335 DKEQ-------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2387 Score = 50.4 bits (119), Expect = 3e-06 Identities = 84/403 (20%), Positives = 165/403 (40%), Gaps = 32/403 (7%) Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85 EA +R + + + R+ L + EG A L A +++ R R + ++G Sbjct: 1658 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAET--EQGEQ 1713 Query: 86 AEAQMRQEIERLTERLEEKEREMQQLLSQPQHER-EKEVVLLRRSMAEGERARAASDVLC 144 + +E+ RL ++ Q+L ++ R E EV+L ++ AE E +R+ S+ Sbjct: 1714 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE-EESRSTSEKSK 1772 Query: 145 RSLANETHQLR---------RTLTATAHMCQHLAK--CLDERQHAQRNVGERSPDQSEHT 193 + L E + R R L A + LA+ +R A+R + E+ E T Sbjct: 1773 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1832 Query: 194 DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253 T + +++ + EN L++ ED + +R ++ + +L L+ + Sbjct: 1833 RLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1889 Query: 254 PELMR-----KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308 EL R ++ R RQ+EE+I ++ AA + + L R++ + L K+ Sbjct: 1890 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1949 Query: 309 DFMSE-------RADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKY 361 E A+ ER + +E +K + + + ++ + + R+ A + A+ Sbjct: 1950 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2009 Query: 362 LAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQ 404 L A + +Q+ E H A Q+ + +LQ Sbjct: 2010 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2052 Score = 49.3 bits (116), Expect = 7e-06 Identities = 75/329 (22%), Positives = 133/329 (40%), Gaps = 51/329 (15%) Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ---- 81 EA QR RRL++Q A A I A+L D+ L+E R R Q+ + Sbjct: 1859 EAFQR-RRLEEQAAQHKADIEERLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILAL 1916 Query: 82 -----EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERA 136 + A +A++ E+ R+ E+ R +Q E E R+ AE ER Sbjct: 1917 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA--------ELEAARQRQLAAEEERR 1968 Query: 137 RA-ASDVLCRSLANETHQLRRT---------LTATAHMCQHLAKCLDERQHAQRNVGERS 186 R A + + +SLA E R+ L A + L + ++ Q + + + Sbjct: 1969 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2028 Query: 187 PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246 + + +V +K QE + L+Q+ + ++ L + + + +E A+ Sbjct: 2029 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEA 2082 Query: 247 GLQIPHEPELMRKEIS---RLNRQLEEKINDCA-----------EVKQELAASRTARDAA 292 +Q E R+++ RL + EE+ A E +QE A A AA Sbjct: 2083 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2142 Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQ 321 L + Q + ++ +K +E+ R++AQ Sbjct: 2143 LRQKQAADAEMEKHKK--FAEQTLRQKAQ 2169 Score = 47.4 bits (111), Expect = 3e-05 Identities = 89/393 (22%), Positives = 165/393 (41%), Gaps = 72/393 (18%) Query: 33 RLQDQLAARDALIARLRARLAAL---------EGDAAPSLVDALLEQVARFREQL----- 78 RLQ + RD + R R R+A L + D ++ L Q+ +RE Sbjct: 1148 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1207 Query: 79 ------RRQE---------GGAAEAQMRQE------IERLTERLEEKEREMQQLLSQPQH 117 RRQE A Q+RQE IER E++EE +R +Q ++ + Sbjct: 1208 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK- 1266 Query: 118 EREKEVVLLR------RSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKC 171 + E ++V + S A+ + ++ S+ + + + T T+ + +++ Sbjct: 1267 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1326 Query: 172 LDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK---LQEENRLLK-QKVTHVEDLNAKW 227 L + +R ++ ++ E V++ +EK L E + K Q ++L + Sbjct: 1327 LRRMEEEERLAEQQRAEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1383 Query: 228 QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287 Q R+E Q R +Q +E+ +L + E +I A+ +Q AA R+ Sbjct: 1384 QEEVVRREEAAVDAQQQKRSIQ---------EELQQLRQSSEAEIQ--AKARQAEAAERS 1432 Query: 288 ----ARDAALERVQM--LEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV--- 338 + + R+Q+ E+Q + + + RA E A+++ ++ +E+ L QV Sbjct: 1433 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1492 Query: 339 SWRQDSREPD-AGRIHAGSKTA--KYLAADALE 368 S R+ E + A R+ A ++ A K A ALE Sbjct: 1493 SQRKRQAEVELASRVKAEAEAAREKQRALQALE 1525 Score = 47.0 bits (110), Expect = 3e-05 Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 46/353 (13%) Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIAR--LRARLAAL-EGDAAPSLVDAL 67 EEA R + A + RLR+L ++ A+ +A L+ ++ A+ E + + L Sbjct: 2264 EEAARLSVAA-----QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2318 Query: 68 LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124 +Q +EQ RR ++++ E++ ++L E+ + Q+ L Q Q E E Sbjct: 2319 QQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2369 Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184 L+ +AE RA+A ++ + + ++ L T Q L + QR + Sbjct: 2370 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSD 2428 Query: 185 RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW--QRYNASRDEYVRGLH 242 D + ++ EKLQ+E +LL+ K ++ + + Q A + ++ Sbjct: 2429 H--DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2486 Query: 243 AQLRGLQIPHEP-----ELMRKEISRLNRQLEEKINDCAEVKQE----LAASRTAR---- 289 + L+ + + +L + E+++ + EE+ +++QE +A+ AR Sbjct: 2487 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2546 Query: 290 ------DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336 E +Q LEQQ +++ ++E R R Q ++ E E+ A+L H Sbjct: 2547 EAEEGVRRKQEELQQLEQQ-RRQQEELLAEENQRLREQLQLLE-EQHRAALAH 2597 Score = 46.2 bits (108), Expect = 6e-05 Identities = 98/393 (24%), Positives = 156/393 (39%), Gaps = 42/393 (10%) Query: 62 SLVDALLEQVARF-REQLRR--QEGGAAEAQMRQEIERLTE--RLEEKEREMQQLLSQPQ 116 S + L Q +F E LRR +E AE Q +E ERL E EK+R++ + +Q + Sbjct: 1310 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1369 Query: 117 HEREKEVVLLRRSMAEG----ERARAASDVLCRSLANETHQLRRTLTA-------TAHMC 165 + E+E L++ M E E A + RS+ E QLR++ A A Sbjct: 1370 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1429 Query: 166 QHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225 + ++E R E + Q +G +Q++ + +E +Q E L Sbjct: 1430 ERSRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRR 1487 Query: 226 KWQRYNASRDEYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAA 284 + Q DE R A++ ++ E E R E R + LEE E ++ L Sbjct: 1488 QVQ------DESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1540 Query: 285 SRTAR----DAALERVQ-MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339 + R ALE Q E ++ + + F + A ER+ +QE VA L + Sbjct: 1541 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAE 1597 Query: 340 WR-QDSREPDAGRIHAGSKTAKY--LAADALELMVPG---GWRPGTGSQQPEPPAEGGHP 393 R Q E + R A + ++ A +AL L + + + E E Sbjct: 1598 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1657 Query: 394 GAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAE 426 A +RG+ + Q Q EQ E R +AE Sbjct: 1658 EARRRGKAEEQAVR--QRELAEQELEKQRQLAE 1688 >gi|47607492 plectin 1 isoform 1 [Homo sapiens] Length = 4574 Score = 60.5 bits (145), Expect = 3e-09 Identities = 84/343 (24%), Positives = 141/343 (41%), Gaps = 50/343 (14%) Query: 11 EEAPRAAAALCTLYHEAGQRLR----RLQDQLAARDALIARLRARLAALEGDAAPSLVDA 66 E+A AA L E +R R R+Q LAA + + +A L +E + A Sbjct: 1990 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER------LKA 2043 Query: 67 LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEE---------KEREMQQLLSQPQH 117 +E+ R RE R ++ A + Q+ QE + + EE KE+E+QQ L Q Q Sbjct: 2044 KVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2101 Query: 118 EREK---EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE 174 ++ E RR+ E E AR ++ E Q RR + + Q + Sbjct: 2102 VLDQLRGEAEAARRAAEEAEEARVQAE-------REAAQSRRQVEEAERLKQSAEEQAQA 2154 Query: 175 RQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLN------AKWQ 228 R AQ E+ ++E Q + Q E L+QK ++ + Sbjct: 2155 RAQAQA-AAEKLRKEAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2205 Query: 229 RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288 R A ++ + L QL + H+ L+ +E+ RL + E ++V++EL + R Sbjct: 2206 RQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2263 Query: 289 RD--AALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEE 329 + + L+ E + L +D ++R +E A+ Q EE Sbjct: 2264 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2306 Score = 57.8 bits (138), Expect = 2e-08 Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 43/360 (11%) Query: 29 QRLRRLQDQLAARDALIARLRARLAAL---EGDAAPSLVDALLEQVARFREQLRRQEGGA 85 + L ++ Q+ L AR+ A AL + D + E++ + E+ R A Sbjct: 2255 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2314 Query: 86 AEA----QMRQEIERLTERLEEK--EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAA 139 EA Q+ +E L EK + +MQ + + + E E++ ++ +A+ + R Sbjct: 2315 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2374 Query: 140 SDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG-- 195 D + + LA ET +RTL A Q + E + + V E S Q+ + Sbjct: 2375 EDKEQMAQQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2431 Query: 196 --HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253 + + EKL ++KVT V+ L + Q Q H+ Sbjct: 2432 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------------QSDHD 2471 Query: 254 PELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR-DAALERVQMLEQQILAYKDDFMS 312 E +R+ I+ L R+ E+ + ++ + +T + + L+ Q L+Q L+ KD + Sbjct: 2472 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2531 Query: 313 ERADRERAQSRIQELEE----KVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368 E+ ++++++L + K L + +Q E + R+ A + A+ +A E Sbjct: 2532 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2591 Score = 51.6 bits (122), Expect = 1e-06 Identities = 86/341 (25%), Positives = 138/341 (40%), Gaps = 26/341 (7%) Query: 26 EAGQRLRR-LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84 E +RLRR +QD+ + L +R+ A E +AA AL + E+LR Q Sbjct: 1521 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRAL-----QALEELRLQ--- 1571 Query: 85 AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG----ERARAAS 140 A EA+ RL + E+ R++Q L Q E E+ R S AE ER+ Sbjct: 1572 AEEAE-----RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1626 Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV- 199 V L E + R A A + A+ ER + N R Q+E S+ Sbjct: 1627 HVAVAQLREEAER-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1685 Query: 200 QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259 Q+ EK +EE ++ E+ + + E R L ++ E EL+R Sbjct: 1686 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR- 1744 Query: 260 EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRER 319 L + E+ +++ELA + AA ++ Q LE ++ + + A + R Sbjct: 1745 ----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1800 Query: 320 AQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360 A+ + EK L + R +A R+ A ++ AK Sbjct: 1801 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1841 Score = 50.8 bits (120), Expect = 2e-06 Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 32/300 (10%) Query: 27 AGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAA 86 A ++LR+ +Q AAR R +A AAL A DA +E+ +F EQ RQ+ Sbjct: 2161 AAEKLRKEAEQEAAR-----RAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---- 2208 Query: 87 EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRS 146 AQ+ QE+ L +LEE + + L ++E+ L+ E R R+ + S Sbjct: 2209 -AQVEQELTTLRLQLEETDHQKNLL--------DEELQRLKAEATEAARQRSQVEEELFS 2259 Query: 147 LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKL 206 + + +L + ++ A L ++ + QR + E + + + + ++ Sbjct: 2260 VRVQMEELSKLKARIE--AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2317 Query: 207 QEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNR 266 +L ++ + L K + + L A+ LQ + EL +++ RL Sbjct: 2318 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ--QQKELAQEQARRLQE 2375 Query: 267 QLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326 E+ + Q+LA LE + + ++ A + A+ RAQ+R +E Sbjct: 2376 DKEQ-------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2428 Score = 50.4 bits (119), Expect = 3e-06 Identities = 84/403 (20%), Positives = 165/403 (40%), Gaps = 32/403 (7%) Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85 EA +R + + + R+ L + EG A L A +++ R R + ++G Sbjct: 1699 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAET--EQGEQ 1754 Query: 86 AEAQMRQEIERLTERLEEKEREMQQLLSQPQHER-EKEVVLLRRSMAEGERARAASDVLC 144 + +E+ RL ++ Q+L ++ R E EV+L ++ AE E +R+ S+ Sbjct: 1755 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE-EESRSTSEKSK 1813 Query: 145 RSLANETHQLR---------RTLTATAHMCQHLAK--CLDERQHAQRNVGERSPDQSEHT 193 + L E + R R L A + LA+ +R A+R + E+ E T Sbjct: 1814 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1873 Query: 194 DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253 T + +++ + EN L++ ED + +R ++ + +L L+ + Sbjct: 1874 RLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1930 Query: 254 PELMR-----KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308 EL R ++ R RQ+EE+I ++ AA + + L R++ + L K+ Sbjct: 1931 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1990 Query: 309 DFMSE-------RADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKY 361 E A+ ER + +E +K + + + ++ + + R+ A + A+ Sbjct: 1991 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2050 Query: 362 LAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQ 404 L A + +Q+ E H A Q+ + +LQ Sbjct: 2051 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2093 Score = 49.3 bits (116), Expect = 7e-06 Identities = 75/329 (22%), Positives = 133/329 (40%), Gaps = 51/329 (15%) Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ---- 81 EA QR RRL++Q A A I A+L D+ L+E R R Q+ + Sbjct: 1900 EAFQR-RRLEEQAAQHKADIEERLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILAL 1957 Query: 82 -----EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERA 136 + A +A++ E+ R+ E+ R +Q E E R+ AE ER Sbjct: 1958 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA--------ELEAARQRQLAAEEERR 2009 Query: 137 RA-ASDVLCRSLANETHQLRRT---------LTATAHMCQHLAKCLDERQHAQRNVGERS 186 R A + + +SLA E R+ L A + L + ++ Q + + + Sbjct: 2010 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2069 Query: 187 PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246 + + +V +K QE + L+Q+ + ++ L + + + +E A+ Sbjct: 2070 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEA 2123 Query: 247 GLQIPHEPELMRKEIS---RLNRQLEEKINDCA-----------EVKQELAASRTARDAA 292 +Q E R+++ RL + EE+ A E +QE A A AA Sbjct: 2124 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2183 Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQ 321 L + Q + ++ +K +E+ R++AQ Sbjct: 2184 LRQKQAADAEMEKHKK--FAEQTLRQKAQ 2210 Score = 47.4 bits (111), Expect = 3e-05 Identities = 89/393 (22%), Positives = 165/393 (41%), Gaps = 72/393 (18%) Query: 33 RLQDQLAARDALIARLRARLAAL---------EGDAAPSLVDALLEQVARFREQL----- 78 RLQ + RD + R R R+A L + D ++ L Q+ +RE Sbjct: 1189 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1248 Query: 79 ------RRQE---------GGAAEAQMRQE------IERLTERLEEKEREMQQLLSQPQH 117 RRQE A Q+RQE IER E++EE +R +Q ++ + Sbjct: 1249 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK- 1307 Query: 118 EREKEVVLLR------RSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKC 171 + E ++V + S A+ + ++ S+ + + + T T+ + +++ Sbjct: 1308 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1367 Query: 172 LDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK---LQEENRLLK-QKVTHVEDLNAKW 227 L + +R ++ ++ E V++ +EK L E + K Q ++L + Sbjct: 1368 LRRMEEEERLAEQQRAEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1424 Query: 228 QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287 Q R+E Q R +Q +E+ +L + E +I A+ +Q AA R+ Sbjct: 1425 QEEVVRREEAAVDAQQQKRSIQ---------EELQQLRQSSEAEIQ--AKARQAEAAERS 1473 Query: 288 ----ARDAALERVQM--LEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV--- 338 + + R+Q+ E+Q + + + RA E A+++ ++ +E+ L QV Sbjct: 1474 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1533 Query: 339 SWRQDSREPD-AGRIHAGSKTA--KYLAADALE 368 S R+ E + A R+ A ++ A K A ALE Sbjct: 1534 SQRKRQAEVELASRVKAEAEAAREKQRALQALE 1566 Score = 47.0 bits (110), Expect = 3e-05 Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 46/353 (13%) Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIAR--LRARLAAL-EGDAAPSLVDAL 67 EEA R + A + RLR+L ++ A+ +A L+ ++ A+ E + + L Sbjct: 2305 EEAARLSVAA-----QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2359 Query: 68 LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124 +Q +EQ RR ++++ E++ ++L E+ + Q+ L Q Q E E Sbjct: 2360 QQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2410 Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184 L+ +AE RA+A ++ + + ++ L T Q L + QR + Sbjct: 2411 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSD 2469 Query: 185 RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW--QRYNASRDEYVRGLH 242 D + ++ EKLQ+E +LL+ K ++ + + Q A + ++ Sbjct: 2470 H--DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2527 Query: 243 AQLRGLQIPHEP-----ELMRKEISRLNRQLEEKINDCAEVKQE----LAASRTAR---- 289 + L+ + + +L + E+++ + EE+ +++QE +A+ AR Sbjct: 2528 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2587 Query: 290 ------DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336 E +Q LEQQ +++ ++E R R Q ++ E E+ A+L H Sbjct: 2588 EAEEGVRRKQEELQQLEQQ-RRQQEELLAEENQRLREQLQLLE-EQHRAALAH 2638 Score = 46.2 bits (108), Expect = 6e-05 Identities = 98/393 (24%), Positives = 156/393 (39%), Gaps = 42/393 (10%) Query: 62 SLVDALLEQVARF-REQLRR--QEGGAAEAQMRQEIERLTE--RLEEKEREMQQLLSQPQ 116 S + L Q +F E LRR +E AE Q +E ERL E EK+R++ + +Q + Sbjct: 1351 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1410 Query: 117 HEREKEVVLLRRSMAEG----ERARAASDVLCRSLANETHQLRRTLTA-------TAHMC 165 + E+E L++ M E E A + RS+ E QLR++ A A Sbjct: 1411 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1470 Query: 166 QHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225 + ++E R E + Q +G +Q++ + +E +Q E L Sbjct: 1471 ERSRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRR 1528 Query: 226 KWQRYNASRDEYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAA 284 + Q DE R A++ ++ E E R E R + LEE E ++ L Sbjct: 1529 QVQ------DESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1581 Query: 285 SRTAR----DAALERVQ-MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339 + R ALE Q E ++ + + F + A ER+ +QE VA L + Sbjct: 1582 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAE 1638 Query: 340 WR-QDSREPDAGRIHAGSKTAKY--LAADALELMVPG---GWRPGTGSQQPEPPAEGGHP 393 R Q E + R A + ++ A +AL L + + + E E Sbjct: 1639 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1698 Query: 394 GAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAE 426 A +RG+ + Q Q EQ E R +AE Sbjct: 1699 EARRRGKAEEQAVR--QRELAEQELEKQRQLAE 1729 >gi|148746195 trichohyalin [Homo sapiens] Length = 1943 Score = 60.1 bits (144), Expect = 4e-09 Identities = 67/280 (23%), Positives = 120/280 (42%), Gaps = 25/280 (8%) Query: 75 REQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGE 134 R++ +E G Q RQE ER EE+ + ++L + + R++E+ R+ E E Sbjct: 125 RDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQERE 184 Query: 135 RARAASDVLCRSLANET------HQLRRTLTATAHMCQHLAKCLDERQHAQRNVGER--- 185 RA + L +ET QLRR + + K +E+Q +R +R Sbjct: 185 ERRAEEEQLQSCKGHETEEFPDEEQLRR-----RELLELRRKGREEKQQQRRERQDRVFQ 239 Query: 186 SPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQL 245 ++ E T ++ EKLQEE ++++ E+ K +R R+ Q Sbjct: 240 EEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQ- 298 Query: 246 RGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILA 305 ++ E +L RK+ Q EE+ + ++E R + E+ + EQQ+ Sbjct: 299 ---RLRREQQLRRKQEEERREQQEERREQ--QERREQQEERREQQLRREQEERREQQLRR 353 Query: 306 YKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSR 345 +++ ER RE+ R QE E + L + R++ + Sbjct: 354 EQEE---ER--REQQLRREQEEERREQQLRREQQLRREQQ 388 Score = 54.7 bits (130), Expect = 2e-07 Identities = 75/306 (24%), Positives = 129/306 (42%), Gaps = 39/306 (12%) Query: 69 EQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHER--------- 119 E+V + EQL R+E E + RQE+ER EE ++E +QLL + Q +R Sbjct: 1144 EEVQQEEEQLLREE---PEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYR 1200 Query: 120 -EKEVVLLRRSMA--------------EGERARAASD--VLCRSLANET-HQLRRTLTAT 161 E+E+ +R E E+ A D V C+ NE QL + Sbjct: 1201 EEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRD 1260 Query: 162 AHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK-LQEENRLLKQKVTHV 220 Q L L E+Q R E+ + + D H + +E+ Q+E + +K Sbjct: 1261 RQSQQDLQHLLGEQQERDR---EQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEE 1317 Query: 221 EDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQ 280 + L + + R E R + + LQ E L R+E R R EE++ + ++ Sbjct: 1318 KQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFR--EEELRHQEQGRK 1375 Query: 281 ELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSW 340 L + R ER + E+Q L ++ R DR+R + +E E++++ + Sbjct: 1376 FLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDR---KFREEEQQLSRQERDRKF 1432 Query: 341 RQDSRE 346 R++ ++ Sbjct: 1433 REEEQQ 1438 Score = 53.9 bits (128), Expect = 3e-07 Identities = 79/293 (26%), Positives = 129/293 (44%), Gaps = 45/293 (15%) Query: 68 LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKE---VV 124 LE+ R +Q RR++ E + R+E +RL +R EE+ER Q+L S+ Q RE+E Sbjct: 491 LEEEERREQQERREQQLRREQEERRE-QRL-KRQEEEERLQQRLRSEQQLRREQEERREQ 548 Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDER--QHAQRNV 182 LL+R E R + + L E + R L K +ER Q +R Sbjct: 549 LLKRE----EEKRLEQERREQRLKREQEERR----------DQLLKREEERRQQRLKREQ 594 Query: 183 GERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLH 242 ER + + + +E+L++E R +Q++ E + Q+ S ++ R Sbjct: 595 EERLEQRLKREE--------VERLEQEER-REQRLKREEPEEERRQQLLKSEEQEERRQQ 645 Query: 243 AQLRGLQIPHEPELMRKE-----ISRLNRQLEE--KINDCAEVKQELAASRTARDAALER 295 R Q E L R+E RL R+ EE + + AE +QE AR+ R Sbjct: 646 QLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE-----QARERIKSR 700 Query: 296 VQMLEQQILAYKDDFMSE---RADRERAQSRIQELEEKVASLLHQVSWRQDSR 345 + + Q+ + D S+ R ++ Q R QE EEK ++ W+++ R Sbjct: 701 IPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEER 753 Score = 52.8 bits (125), Expect = 6e-07 Identities = 74/312 (23%), Positives = 129/312 (41%), Gaps = 54/312 (17%) Query: 69 EQVARFREQLRR---------------------QEGGAAEAQMRQEIERLTE----RLEE 103 +Q R +QLRR Q+ E Q+R+E E E R +E Sbjct: 297 QQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQE 356 Query: 104 KEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAH 163 +ER QQL + + ER ++ + + + ++ R + QLRR Sbjct: 357 EERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 416 Query: 164 MC----QHLAKCLDERQHAQRNVGER-----SPDQSEHTDGHTSVQSVIEKLQEENRLLK 214 Q L + +E +H Q++ ER +Q E D + E+ ++E R + Sbjct: 417 QQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRD-WLKREEETERHEQERRKQQ 475 Query: 215 QKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKIND 274 K E+ +W + +E R + R Q+ E E R++ RL RQ EE+ Sbjct: 476 LKRDQEEERRERWLKL----EEEERREQQERREQQLRREQEERREQ--RLKRQEEEE--- 526 Query: 275 CAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRI-QELEEKVAS 333 ++Q L + + R ER +Q+L +++ +R ++ER + R+ +E EE+ Sbjct: 527 --RLQQRLRSEQQLRREQEER----REQLLKREEE---KRLEQERREQRLKREQEERRDQ 577 Query: 334 LLHQVSWRQDSR 345 LL + R+ R Sbjct: 578 LLKREEERRQQR 589 Score = 51.2 bits (121), Expect = 2e-06 Identities = 76/341 (22%), Positives = 138/341 (40%), Gaps = 34/341 (9%) Query: 29 QRLRRLQDQLAARDALIARLRARLAA-LEGDAAPSLVDALL-EQVARFREQLRRQEGGAA 86 QRL+R Q++ RD L+ R R L+ + L L E+V R ++ RR++ Sbjct: 565 QRLKREQEE--RRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKR 622 Query: 87 EAQMRQEIERLTERLEEKEREMQQLLSQPQHER-------EKEVVLLRRSMAEGERARAA 139 E + ++L + E++ER QQL + Q R E+E L +R E E R Sbjct: 623 EEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERRE 682 Query: 140 SDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV 199 ++ +++ + + A + +++ E + E + Sbjct: 683 QELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRR 742 Query: 200 QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259 +S ++ QEE R +Q+ + + WQ + E R + L+ E +L + Sbjct: 743 ESELQ-WQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAE 801 Query: 260 EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQ-------QILAYKDDFMS 312 E +Q E++ E K++ R R+ L+ ++ EQ Q L ++D + Sbjct: 802 E----RQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQ 857 Query: 313 ERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIH 353 E D+ER +S+ Q ++K WR E R H Sbjct: 858 E--DQERRRSQEQRRDQK---------WRWQLEEERKRRRH 887 Score = 50.4 bits (119), Expect = 3e-06 Identities = 64/281 (22%), Positives = 115/281 (40%), Gaps = 46/281 (16%) Query: 69 EQVARFREQLRRQEGGAAEAQMRQE----IERLTERLEEKEREMQQLLSQPQHEREKEVV 124 EQ R +QLRR++ E Q+R+E E+ R ++ RE ++ + +HE+E+ Sbjct: 386 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQ 445 Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184 L+R E D L R E H+ R + L Q +R Sbjct: 446 RLKREQEE------RRDWLKREEETERHEQERR-----------KQQLKRDQEEERRERW 488 Query: 185 RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQ 244 ++ E + + + + QEE R +Q++ E+ QR + + Q Sbjct: 489 LKLEEEERREQQERREQQLRREQEERR--EQRLKRQEEEERLQQRLRSEQ---------Q 537 Query: 245 LRGLQIPHEPELMRKE----------ISRLNRQLEEKINDCAEVKQELAASRTARDAALE 294 LR Q +L+++E RL R+ EE+ + + ++E R R E Sbjct: 538 LRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKR----E 593 Query: 295 RVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLL 335 + + LEQ++ + + + + RE+ R + EE+ LL Sbjct: 594 QEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLL 634 Score = 49.7 bits (117), Expect = 5e-06 Identities = 53/256 (20%), Positives = 110/256 (42%), Gaps = 24/256 (9%) Query: 76 EQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGER 135 E+ RR+ A+ +++++ + + L+E+E E+Q+ + + +E+E R E E+ Sbjct: 881 ERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQE-----RQYREEEQ 935 Query: 136 ARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG 195 + + L R + + R + K +Q ++ +GE P++ + Sbjct: 936 LQQEEEQLLREEREKRRRQERE--------RQYRKDKKLQQKEEQLLGE-EPEKRRRQER 986 Query: 196 HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPE 255 + E QEE +LL+++ + +W+R +DE + LR E Sbjct: 987 EKKYREEEELQQEEEQLLREE--REKRRRQEWERQYRKKDELQQEEEQLLR-------EE 1037 Query: 256 LMRKEISRLNRQLEEKINDCAEVKQELAASR-TARDAALERVQMLEQQILAYKDDFMSER 314 ++ + RQ E+ E +Q L R T R LER E+++ ++ + E Sbjct: 1038 REKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREE 1097 Query: 315 ADRERAQSRIQELEEK 330 ++ R Q R ++ E+ Sbjct: 1098 PEKRRRQERERQCREE 1113 Score = 47.4 bits (111), Expect = 3e-05 Identities = 61/260 (23%), Positives = 105/260 (40%), Gaps = 20/260 (7%) Query: 76 EQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGER 135 +QLRRQE G Q R R E+L + ERE QQL Q ER+++ L + + E+ Sbjct: 1538 QQLRRQERGQQRRQDRDRKFREEEQLRQ-EREEQQLSRQ---ERDRKFRLEEQKVRRQEQ 1593 Query: 136 ARAASDVLCRSLANE-THQLR----RTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQS 190 R + + E QLR R + Q + RQ R E P Sbjct: 1594 ERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLR 1653 Query: 191 EHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQI 250 K +EE +LL++ + Q RD R QLR + Sbjct: 1654 RQEREQQLRHDRDRKFREEEQLLQE--------GEEQQLRRQERDRKFREEEQQLRRQE- 1704 Query: 251 PHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDF 310 E + +++E ++LE K + +++QE + R ++ + E+Q+ +++ Sbjct: 1705 -RERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKI-LEEEQLRPEREEQ 1762 Query: 311 MSERADRERAQSRIQELEEK 330 R +R+R ++L ++ Sbjct: 1763 QLRRQERDRKFREEEQLRQE 1782 Score = 47.0 bits (110), Expect = 3e-05 Identities = 58/274 (21%), Positives = 124/274 (45%), Gaps = 39/274 (14%) Query: 69 EQVARFRE--QLRRQEGGAAEAQMRQEIERLTERLEEKE--------REMQQLLSQPQHE 118 E+ R RE +LRR+ + Q R+ +R+ + EEKE R+ ++ L + + + Sbjct: 207 EEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ 266 Query: 119 REKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHA 178 R++E+ E E+ R R E Q ++ L + + + E+Q Sbjct: 267 RQREL------QEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEE 320 Query: 179 QRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYV 238 +R ER Q E + + + QEE R +Q++ ++ + Q+ ++E Sbjct: 321 RREQQERREQQEERR------EQQLRREQEERR--EQQLRREQEEERREQQLRREQEE-- 370 Query: 239 RGLHAQLRGLQIPHEPELMRKEISRLNRQL--EEKINDCAEVKQELAASRTARDAALERV 296 + R Q+ E +L R++ R +QL E+++ ++++E + R+ L R Sbjct: 371 -----ERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE---QQLRREQQLRRE 422 Query: 297 QMLEQQILAYKDDFMSERADRERAQSRIQELEEK 330 Q L ++ +++ ++ ++ER + R++ +E+ Sbjct: 423 QQLRRE---QEEERHEQKHEQERREQRLKREQEE 453 Score = 47.0 bits (110), Expect = 3e-05 Identities = 69/293 (23%), Positives = 119/293 (40%), Gaps = 42/293 (14%) Query: 69 EQVARFRE---QLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQ------HER 119 E+ +FRE Q+RRQE E + +E ++L + K RE +QLL + + ER Sbjct: 1427 ERDRKFREEEQQVRRQE---RERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQER 1483 Query: 120 EKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQ 179 +++ + + + ER R + RS E L H Q K L E Q + Sbjct: 1484 DRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEE--EQQLHRQQRQRKFLQEEQQLR 1541 Query: 180 RNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVR 239 R ER + + D + + + +EE +L +Q+ D + + R E R Sbjct: 1542 RQ--ERGQQRRQDRDRKFREEEQLRQEREEQQLSRQE----RDRKFRLEEQKVRRQEQER 1595 Query: 240 GLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAE------------VKQELAASRT 287 + L+ + +R+E R R+ E+ + + E +++E R Sbjct: 1596 KFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQ 1655 Query: 288 ARDAAL----ERVQMLEQQILAYKDDFMSERADRER------AQSRIQELEEK 330 R+ L +R E+Q+L ++ R +R+R Q R QE E K Sbjct: 1656 EREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERK 1708 Score = 46.2 bits (108), Expect = 6e-05 Identities = 63/285 (22%), Positives = 115/285 (40%), Gaps = 21/285 (7%) Query: 68 LEQVARFREQLRRQEGGAAEAQMR--QEIERLTERLEEKEREMQQLLSQPQHER-----E 120 LE+ R R Q R ++ E Q+R + ++L + + K RE +Q LS+ + +R E Sbjct: 1377 LEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEE 1436 Query: 121 KEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQR 180 ++V R E + R E L+ H + K L+E Q +R Sbjct: 1437 QQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRR 1496 Query: 181 NVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRG 240 +R + E + + E+ Q + ++K E + +R R + R Sbjct: 1497 QERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRK 1556 Query: 241 LHAQLRGLQIPHEPELMRKEISRLNRQLEEKI------NDCAEVKQELAASRTARDAALE 294 + + Q E +L R+E R R E+K+ E +Q+L + E Sbjct: 1557 FREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQE 1616 Query: 295 RVQML--EQQILAYKDDFMSERADRER------AQSRIQELEEKV 331 R + ++Q+L +++ R +R+R Q R QE E+++ Sbjct: 1617 RDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQL 1661 Score = 45.8 bits (107), Expect = 7e-05 Identities = 57/264 (21%), Positives = 116/264 (43%), Gaps = 15/264 (5%) Query: 69 EQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRR 128 E+ R ++ +E E +R+E E+L E +++RE+Q+ Q + E++ + R Sbjct: 232 ERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQ-LRKLERQELRRER 290 Query: 129 SMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDER--QHAQRNVGERS 186 E ++ R + + L + + RR Q + +ER Q +R ER Sbjct: 291 QEEEQQQQRLRRE---QQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERR 347 Query: 187 PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246 Q + + + QEE R +Q++ + L + Q R++ +R R Sbjct: 348 EQQLRREQEEERREQQLRREQEEER-REQQLRREQQLRREQQ---LRREQQLRREQQLRR 403 Query: 247 GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAY 306 Q+ E +L R++ R +QL + E + E + R+ L+R Q + L Sbjct: 404 EQQLRREQQLRREQQLRREQQLR---REQEEERHEQKHEQERREQRLKREQEERRDWLKR 460 Query: 307 KDDFMSERADRERAQSRIQELEEK 330 +++ +ER ++ER + +++ +E+ Sbjct: 461 EEE--TERHEQERRKQQLKRDQEE 482 Score = 45.1 bits (105), Expect = 1e-04 Identities = 84/353 (23%), Positives = 133/353 (37%), Gaps = 73/353 (20%) Query: 26 EAGQRLRRLQDQLAARDALIARLRA--RLAALEGDAAPSLVDALL---EQVARFRE---Q 77 E GQ+ R+ +D+ + + + R +L+ E D L + + EQ +F E Q Sbjct: 1544 ERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQ 1603 Query: 78 LRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLL------------------------- 112 LRRQEG + Q+RQE +R K RE +QLL Sbjct: 1604 LRRQEG---QQQLRQERDR-------KFREDEQLLQEREEQQLHRQERDRKFLEEEPQLR 1653 Query: 113 -----SQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQH 167 Q +H+R+++ + + EGE + R E QLRR + Sbjct: 1654 RQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ--------ER 1705 Query: 168 LAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW 227 K L E Q +R ER + E T E+L+ + R +K+ E L + Sbjct: 1706 ERKFLQEEQQLRRQELERKFREEEQLRQETEQ----EQLRRQERY--RKILEEEQLRPER 1759 Query: 228 QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287 + R E R + + Q E +L +E R R+ EE++ E +Q R Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFRE-EEQLRQEREEQQLRPQQRD 1818 Query: 288 ARDAALERVQMLEQQILAYK----------DDFMSERADRERAQSRIQELEEK 330 + E LE+Q + + F ++ R Q QE E+K Sbjct: 1819 GKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQK 1871 Score = 43.5 bits (101), Expect = 4e-04 Identities = 68/310 (21%), Positives = 121/310 (39%), Gaps = 45/310 (14%) Query: 70 QVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKER-----EMQQLLSQPQHE------ 118 ++A EQ +QE + R++ E +R E +ER E +QL S HE Sbjct: 147 ELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPD 206 Query: 119 ----REKEVVLLRRSMAE--GERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCL 172 R +E++ LRR E ++ R D + + + + R T+ + + K Sbjct: 207 EEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETV-----LRKEEEKLQ 261 Query: 173 DERQHAQRNVGE--------------RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVT 218 +E QR + E R + E + + + QEE R +++ Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER--REQQE 319 Query: 219 HVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEV 278 + + ++ R++ +R + R Q+ E E R+E Q EE+ Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRR 379 Query: 279 KQELAASRTARDAALERVQML--EQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336 +Q+L R+ L R Q L EQQ+ + ++ RE+ R Q+L + H Sbjct: 380 EQQL-----RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERH 434 Query: 337 QVSWRQDSRE 346 + Q+ RE Sbjct: 435 EQKHEQERRE 444 Score = 43.5 bits (101), Expect = 4e-04 Identities = 78/332 (23%), Positives = 140/332 (42%), Gaps = 41/332 (12%) Query: 29 QRLRRLQDQLAARDALIARLRARLAALEGDAAPSLV----DALLEQVARFREQLRRQEGG 84 QRL+R +++ + L R +L + + L+ + LEQ R ++L+R++ Sbjct: 517 QRLKRQEEEERLQQRL--RSEQQLRREQEERREQLLKREEEKRLEQERR-EQRLKREQEE 573 Query: 85 AAEAQMRQEIERLTERLE-EKEREMQQLLSQPQHER----EKEVVLLRRSMAEGERARAA 139 + +++E ER +RL+ E+E ++Q L + + ER E+ L+R E ER + Sbjct: 574 RRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQ- 632 Query: 140 SDVLCRSLANE---THQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGH 196 L +S E QLRR Q L + +E + QR E ++ E Sbjct: 633 ---LLKSEEQEERRQQQLRREQQERRE--QRLKREEEEERLEQRLKREHEEERREQELAE 687 Query: 197 TSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQR-YNASRDEYVRGLHAQLRGLQIPHEPE 255 + E++ ++R+ K + + +A+ + Y+ R + + + + E E Sbjct: 688 EEQEQARERI--KSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESE 745 Query: 256 LMRKEISRLNRQL--EEKINDC-----AEVKQELAASRTA----------RDAALERVQM 298 L +E R +RQ EE+ D AE K E R + R E Q Sbjct: 746 LQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQ 805 Query: 299 LEQQILAYKDDFMSERADRERAQSRIQELEEK 330 EQ+ L +++ R R + +Q LEE+ Sbjct: 806 REQRFLPEEEEKEQRRRQRREREKELQFLEEE 837 Score = 42.7 bits (99), Expect = 6e-04 Identities = 57/284 (20%), Positives = 116/284 (40%), Gaps = 49/284 (17%) Query: 69 EQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRR 128 EQ+ R + RR++ + + + E+++ E+L +ERE ++L + + RE+E + Sbjct: 1001 EQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEE 1060 Query: 129 SMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPD 188 GE R Q R+ +E Q + + P+ Sbjct: 1061 EQLLGEERET------RRRQELERQYRKE---------------EELQQEEEQLLREEPE 1099 Query: 189 QSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGL 248 + + + E QEE +LL++ +R R E R + Sbjct: 1100 KRRRQERERQCREEEELQQEEEQLLRE------------EREKRRRQELERQYREEEEVQ 1147 Query: 249 QIPHEPELMRKEISRLNRQ-LEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYK 307 Q E +L+R+E + RQ LE + + E++QE + R+ +R Q E+Q Y+ Sbjct: 1148 Q--EEEQLLREEPEKRRRQELERQYREEEELQQE--EEQLLREEQEKRRQERERQ---YR 1200 Query: 308 DDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGR 351 ++ E R++ + R ++ +++ + W+ + + +A R Sbjct: 1201 EE---EELQRQKRKQRYRDEDQR-----SDLKWQWEPEKENAVR 1236 Score = 40.8 bits (94), Expect = 0.002 Identities = 73/305 (23%), Positives = 120/305 (39%), Gaps = 49/305 (16%) Query: 69 EQVARFREQLRRQEGGAAEAQMRQEIERLT-----ERLEEKEREMQQLLSQPQHEREKEV 123 E+ R +L+ QE A Q ++E +R + E+ ER Q+L ++P ++E Sbjct: 737 EKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRE- 795 Query: 124 VLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG 183 R + ER + L E Q RR Q L +E + QR Sbjct: 796 ----RQLRAEERQQREQRFLPEE--EEKEQRRRQRREREKELQFL----EEEEQLQRR-- 843 Query: 184 ERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHA 243 ER+ E DG +++ QE R +Q+ D +WQ R L+A Sbjct: 844 ERAQQLQEEEDG-------LQEDQERRRSQEQR----RDQKWRWQ-LEEERKRRRHTLYA 891 Query: 244 QLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQI 303 + P E +RKE L + EE + E ++ R R+ E++Q E+Q+ Sbjct: 892 K------PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREE--EQLQQEEEQL 943 Query: 304 LAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLA 363 L R +RE+ + + +E + + L Q + EP+ R K KY Sbjct: 944 L---------REEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREK--KYRE 992 Query: 364 ADALE 368 + L+ Sbjct: 993 EEELQ 997 Score = 36.6 bits (83), Expect = 0.045 Identities = 58/252 (23%), Positives = 96/252 (38%), Gaps = 47/252 (18%) Query: 73 RFREQLRRQEGGAAEAQMRQEIERL----TERLEEKEREMQQLLSQPQHEREKEVVLLRR 128 +FRE+ + + G + RQE +R ++L +ERE + L + Q R++ L R Sbjct: 1668 KFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQE----LER 1723 Query: 129 SMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE-------------R 175 E E+ R + E QLRR + K L+E R Sbjct: 1724 KFREEEQLRQET---------EQEQLRRQ--------ERYRKILEEEQLRPEREEQQLRR 1766 Query: 176 QHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKV-----THVEDLNAKWQRY 230 Q R E + E + Q K +EE +L +++ D +W+ Sbjct: 1767 QERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEE 1826 Query: 231 NASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARD 290 +E + L Q R Q E + +E S R+ E+++ E K+ R R+ Sbjct: 1827 QLQLEEQEQRLR-QERDRQYRAEEQFATQEKS---RREEQELWQEEEQKRRQERERKLRE 1882 Query: 291 AALERVQMLEQQ 302 + R Q EQ+ Sbjct: 1883 EHIRRQQKEEQR 1894 Score = 29.3 bits (64), Expect = 7.2 Identities = 21/80 (26%), Positives = 38/80 (47%), Gaps = 12/80 (15%) Query: 67 LLEQVARFRE----QLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKE 122 L EQ R R+ Q R +E A + + R+E + L + E+K R+ ++ + +H Sbjct: 1830 LEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEH----- 1884 Query: 123 VVLLRRSMAEGERARAASDV 142 +RR E +R R ++ Sbjct: 1885 ---IRRQQKEEQRHRQVGEI 1901 >gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sapiens] Length = 1116 Score = 59.7 bits (143), Expect = 5e-09 Identities = 87/366 (23%), Positives = 159/366 (43%), Gaps = 70/366 (19%) Query: 10 WEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLE 69 WEE + AA L E GQ ++ +L+ +D + L+ +L L + S + Sbjct: 454 WEELKKKAAGLQA---EIGQ----VKQELSRKDTELLALQTKLETLTNQFSDSK-----Q 501 Query: 70 QVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQ------------- 116 + +E L +E AA Q E++ L RLEEKE + + Q Q Sbjct: 502 HIEVLKESLTAKEQRAAILQT--EVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEI 559 Query: 117 HE-------REKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLA 169 H+ +E++V +L++ + + + SL L+ T T L Sbjct: 560 HDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLE 619 Query: 170 KCLDERQHA-QRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQ 228 + L E++ +R +R D+ E Q I+ +++ + LK+KV+ ++ ++ + Sbjct: 620 EALAEKERTIERLKEQRDRDEREK-------QEEIDNYKKDLKDLKEKVSLLQGDLSEKE 672 Query: 229 RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288 E+ L + GL+ + L EI+ LE+K +C +++ +L + A Sbjct: 673 ASLLDLKEHASSLASS--GLK--KDSRLKTLEIA-----LEQKKEECLKMESQL---KKA 720 Query: 289 RDAALE---------RVQMLEQQILAYKDDFMSERADRERAQSRIQELE-------EKVA 332 +AALE R+Q LE++I YKD+ +A+ +R ++E+E +K+A Sbjct: 721 HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIA 780 Query: 333 SLLHQV 338 L QV Sbjct: 781 ELERQV 786 Score = 43.9 bits (102), Expect = 3e-04 Identities = 61/307 (19%), Positives = 133/307 (43%), Gaps = 35/307 (11%) Query: 64 VDALLEQVAR----FREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHER 119 +++LLEQ + RE++ R+ A ++ + ++ + E + K M++ L + Sbjct: 346 LESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGL----RDL 401 Query: 120 EKEVVLLRRSMA----EGERARAASDVL---CRSLANETHQLRRTLTATAHMCQHLAKCL 172 E+E+ +L+ + A E E +V + + N+ QL+ L++ + L K Sbjct: 402 EEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKK-- 459 Query: 173 DERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHV-EDLNAKWQRYN 231 + Q +G+ + S ++Q+ +E L + KQ + + E L AK QR Sbjct: 460 -KAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAA 518 Query: 232 ASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEK---------INDCAEVKQ-E 281 + E L++ + ++ K+ ++ EEK + D +VK+ + Sbjct: 519 ILQTE------VDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERK 572 Query: 282 LAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWR 341 + + + E+++ E+Q+ + K+ S +AD + + LEE +A + Sbjct: 573 VNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERL 632 Query: 342 QDSREPD 348 ++ R+ D Sbjct: 633 KEQRDRD 639 Score = 30.0 bits (66), Expect = 4.2 Identities = 52/245 (21%), Positives = 96/245 (39%), Gaps = 28/245 (11%) Query: 25 HEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84 ++ +++ L+ Q+ ++ +A L+ + + +A L +A R RE Sbjct: 773 NDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEA------RRREDNLNDSSQ 826 Query: 85 AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVL- 143 + +R++ +R+ E LEE RE Q+ + E+E+VL + A + ++L Sbjct: 827 QLQDSLRKKDDRI-EELEEALRESVQITA------EREMVLAQEESARTNAEKQVEELLM 879 Query: 144 -CRSLANETHQLRRTLTAT----AHMCQHLAKCLDERQHAQRNVGERSPD-------QSE 191 + E ++ L++T A HL ER+ V E + + + Sbjct: 880 AMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKD 939 Query: 192 HTDGHTSVQSVIEKLQEENRLLK-QKVTHVEDLNAKWQ-RYNASRDEYVRGLHAQLRGLQ 249 + S +K QEE LK +K V+ L + Q R D Y Q Sbjct: 940 ANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQ 999 Query: 250 IPHEP 254 H+P Sbjct: 1000 TNHKP 1004 >gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo sapiens] Length = 1972 Score = 59.7 bits (143), Expect = 5e-09 Identities = 88/386 (22%), Positives = 158/386 (40%), Gaps = 47/386 (12%) Query: 2 SRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAP 61 S+D E ++ AL T E +L L+D+L A + RL + AL+G Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578 Query: 62 SLVDALLEQVARFREQLRRQEGGAAEAQMRQEIER--------LTERLEEKEREMQQLLS 113 L A EQ R QL+RQ E + E ER ++LE ++++ Sbjct: 1579 DL-QARDEQNEEKRRQLQRQ---LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1634 Query: 114 QPQHEREKEVVLLRRSMA-------EGERARAASDVLCRSLANETHQLRRTLTATAHMCQ 166 RE+ + LR+ A E E ARA+ D + + A E + ++L A Q Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF-ATAKENEKKAKSLEADLMQLQ 1693 Query: 167 H-LAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225 LA R+ A E + + + G + LQ+E R L+ ++ +E+ Sbjct: 1694 EDLAAAERARKQADLEKEELAEELASSLSGRNA-------LQDEKRRLEARIAQLEEELE 1746 Query: 226 KWQRYNASRDEYVRGLHAQLRGL--------QIPHEPELMRKEISRLNRQLEEKINDC-A 276 + Q + + VR Q L + E R+++ R N++L K+++ Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1806 Query: 277 EVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336 VK + ++ A +A ++ LE+Q+ E +++ A +++ ++K+ +L Sbjct: 1807 AVKSKFKSTIAALEA---KIAQLEEQV-------EQEAREKQAATKSLKQKDKKLKEILL 1856 Query: 337 QVSWRQDSREPDAGRIHAGSKTAKYL 362 QV + E + G+ K L Sbjct: 1857 QVEDERKMAEQYKEQAEKGNARVKQL 1882 Score = 52.8 bits (125), Expect = 6e-07 Identities = 72/362 (19%), Positives = 153/362 (42%), Gaps = 39/362 (10%) Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPS-------- 62 +E R + T + + LQDQL L ++ L + S Sbjct: 1325 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1384 Query: 63 -LVDALLEQVARFREQLRR-----QEGGAA-------EAQMRQEIE----------RLTE 99 V+AL E RF++++ +E AA + +++QE++ +L Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444 Query: 100 RLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLT 159 LE+K+R+ QLL++ ++ K R+ AE + L R+L E + + L Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL-EEALEAKEELE 1503 Query: 160 ATAHMCQ-HLAKCLDERQHAQRNVGERSPD----QSEHTDGHTSVQSVIEKLQEENRLLK 214 T M + + + + +NV E +++ + T ++ + ++LQ Sbjct: 1504 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1563 Query: 215 QKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPEL--MRKEISRLNRQLEEKI 272 + +++ L +++R +RDE QL+ +E EL RK+ + ++ Sbjct: 1564 RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1623 Query: 273 NDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVA 332 D +++ + ++ R+ A+++++ L+ Q+ ++ + RA R+ + +E E+K Sbjct: 1624 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1683 Query: 333 SL 334 SL Sbjct: 1684 SL 1685 Score = 51.6 bits (122), Expect = 1e-06 Identities = 65/266 (24%), Positives = 122/266 (45%), Gaps = 24/266 (9%) Query: 85 AAEAQMRQEI-ERLTERLEEKEREMQQLLSQPQHEREK---EVVLLRRSMAEGERARAAS 140 AA+ Q +EI + RLEE+E QQL Q ER+K +++ L + E E AR Sbjct: 914 AAKKQELEEILHEMEARLEEEEDRGQQL----QAERKKMAQQMLDLEEQLEEEEAAR--- 966 Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQ 200 + QL + +TA A + + + L + ER + +D T++ Sbjct: 967 ---------QKLQLEK-VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1016 Query: 201 SVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPEL--MR 258 EK + +L + + + +L + ++ SR E + L +L G ++ ++ Sbjct: 1017 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKLEGDASDFHEQIADLQ 1075 Query: 259 KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRE 318 +I+ L QL +K + L ++ AL++++ LE I ++D SERA R Sbjct: 1076 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1135 Query: 319 RAQSRIQELEEKVASLLHQVSWRQDS 344 +A+ + ++L E++ +L ++ DS Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTLDS 1161 Score = 47.4 bits (111), Expect = 3e-05 Identities = 75/356 (21%), Positives = 148/356 (41%), Gaps = 61/356 (17%) Query: 31 LRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG------ 84 L RL D++A ++ + ++R LEG + D E+ AR + + ++++ G Sbjct: 1096 LARLDDEIAQKNNALKKIRE----LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1151 Query: 85 -----------AAEAQMR----QEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRS 129 A + ++R QE+ L + L+E+ R + + + + + + V L Sbjct: 1152 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1211 Query: 130 MAEGERARAASDVLCRSLANETHQLR---RTLTATAHMCQHLAKCLDER-QHAQRNVGER 185 + + +RA+A D ++L E L R L +H K L+ + Q Q + Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271 Query: 186 SPDQSEHTDGHTSVQSVIE--------------KLQEENRLLKQKVTHVEDLNAKWQRYN 231 ++E D +Q+ +E KL ++ L ++ ++L + R Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331 Query: 232 ASRDEYVRGLHAQLRGLQIPHEPEL-----MRKEISRLNRQL---EEKINDCAEVKQELA 283 + +R L + LQ + E+ + + IS LN QL ++K+ D A + L Sbjct: 1332 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1391 Query: 284 ASRTARDAALERV-QMLEQQILAYKDDFMSERADRERAQSRI-QELEEKVASLLHQ 337 + +E + Q E++ AY E+ ++R+ QEL++ V L +Q Sbjct: 1392 EGKKRFQKEIENLTQQYEEKAAAYD--------KLEKTKNRLQQELDDLVVDLDNQ 1439 Score = 41.2 bits (95), Expect = 0.002 Identities = 56/276 (20%), Positives = 110/276 (39%), Gaps = 45/276 (16%) Query: 32 RRLQDQLAARDALIARLRA---RLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEA 88 R L+D A+RD + A + + +LE D D + AR + L ++E A Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718 Query: 89 --------------QMRQEIERLTERLEEKEREMQQL------LSQPQHEREKEVVLLRR 128 ++ I +L E LEE++ M+ + +Q + E+ R Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778 Query: 129 SMAEGERARAASDVLCRSLANETHQL--------RRTLTATAHMCQHLAKCLD----ERQ 176 + + E AR + + L ++ H++ + T+ A L + ++ E+Q Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838 Query: 177 HAQRNVGERSPDQSEHT----DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNA 232 A +++ ++ E D + E+ ++ N +KQ +E+ + QR NA Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898 Query: 233 SRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQL 268 +R + R L + E M +E++ L +L Sbjct: 1899 NRRKLQRELD------EATESNEAMGREVNALKSKL 1928 Score = 29.6 bits (65), Expect = 5.5 Identities = 17/77 (22%), Positives = 39/77 (50%) Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRI 352 L +V E+++ A +D+ + +++A++ ++ELE+K + L + + Q+ + + Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903 Query: 353 HAGSKTAKYLAADALEL 369 + LAA EL Sbjct: 904 AEAEEMRVRLAAKKQEL 920 >gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo sapiens] Length = 1979 Score = 59.7 bits (143), Expect = 5e-09 Identities = 88/386 (22%), Positives = 158/386 (40%), Gaps = 47/386 (12%) Query: 2 SRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAP 61 S+D E ++ AL T E +L L+D+L A + RL + AL+G Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585 Query: 62 SLVDALLEQVARFREQLRRQEGGAAEAQMRQEIER--------LTERLEEKEREMQQLLS 113 L A EQ R QL+RQ E + E ER ++LE ++++ Sbjct: 1586 DL-QARDEQNEEKRRQLQRQ---LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1641 Query: 114 QPQHEREKEVVLLRRSMA-------EGERARAASDVLCRSLANETHQLRRTLTATAHMCQ 166 RE+ + LR+ A E E ARA+ D + + A E + ++L A Q Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF-ATAKENEKKAKSLEADLMQLQ 1700 Query: 167 H-LAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225 LA R+ A E + + + G + LQ+E R L+ ++ +E+ Sbjct: 1701 EDLAAAERARKQADLEKEELAEELASSLSGRNA-------LQDEKRRLEARIAQLEEELE 1753 Query: 226 KWQRYNASRDEYVRGLHAQLRGL--------QIPHEPELMRKEISRLNRQLEEKINDC-A 276 + Q + + VR Q L + E R+++ R N++L K+++ Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1813 Query: 277 EVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336 VK + ++ A +A ++ LE+Q+ E +++ A +++ ++K+ +L Sbjct: 1814 AVKSKFKSTIAALEA---KIAQLEEQV-------EQEAREKQAATKSLKQKDKKLKEILL 1863 Query: 337 QVSWRQDSREPDAGRIHAGSKTAKYL 362 QV + E + G+ K L Sbjct: 1864 QVEDERKMAEQYKEQAEKGNARVKQL 1889 Score = 52.8 bits (125), Expect = 6e-07 Identities = 72/362 (19%), Positives = 153/362 (42%), Gaps = 39/362 (10%) Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPS-------- 62 +E R + T + + LQDQL L ++ L + S Sbjct: 1332 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391 Query: 63 -LVDALLEQVARFREQLRR-----QEGGAA-------EAQMRQEIE----------RLTE 99 V+AL E RF++++ +E AA + +++QE++ +L Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451 Query: 100 RLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLT 159 LE+K+R+ QLL++ ++ K R+ AE + L R+L E + + L Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL-EEALEAKEELE 1510 Query: 160 ATAHMCQ-HLAKCLDERQHAQRNVGERSPD----QSEHTDGHTSVQSVIEKLQEENRLLK 214 T M + + + + +NV E +++ + T ++ + ++LQ Sbjct: 1511 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1570 Query: 215 QKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPEL--MRKEISRLNRQLEEKI 272 + +++ L +++R +RDE QL+ +E EL RK+ + ++ Sbjct: 1571 RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1630 Query: 273 NDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVA 332 D +++ + ++ R+ A+++++ L+ Q+ ++ + RA R+ + +E E+K Sbjct: 1631 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1690 Query: 333 SL 334 SL Sbjct: 1691 SL 1692 Score = 51.6 bits (122), Expect = 1e-06 Identities = 65/266 (24%), Positives = 122/266 (45%), Gaps = 24/266 (9%) Query: 85 AAEAQMRQEI-ERLTERLEEKEREMQQLLSQPQHEREK---EVVLLRRSMAEGERARAAS 140 AA+ Q +EI + RLEE+E QQL Q ER+K +++ L + E E AR Sbjct: 921 AAKKQELEEILHEMEARLEEEEDRGQQL----QAERKKMAQQMLDLEEQLEEEEAAR--- 973 Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQ 200 + QL + +TA A + + + L + ER + +D T++ Sbjct: 974 ---------QKLQLEK-VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1023 Query: 201 SVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPEL--MR 258 EK + +L + + + +L + ++ SR E + L +L G ++ ++ Sbjct: 1024 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKLEGDASDFHEQIADLQ 1082 Query: 259 KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRE 318 +I+ L QL +K + L ++ AL++++ LE I ++D SERA R Sbjct: 1083 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1142 Query: 319 RAQSRIQELEEKVASLLHQVSWRQDS 344 +A+ + ++L E++ +L ++ DS Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTLDS 1168 Score = 47.4 bits (111), Expect = 3e-05 Identities = 75/356 (21%), Positives = 148/356 (41%), Gaps = 61/356 (17%) Query: 31 LRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG------ 84 L RL D++A ++ + ++R LEG + D E+ AR + + ++++ G Sbjct: 1103 LARLDDEIAQKNNALKKIRE----LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1158 Query: 85 -----------AAEAQMR----QEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRS 129 A + ++R QE+ L + L+E+ R + + + + + + V L Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218 Query: 130 MAEGERARAASDVLCRSLANETHQLR---RTLTATAHMCQHLAKCLDER-QHAQRNVGER 185 + + +RA+A D ++L E L R L +H K L+ + Q Q + Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278 Query: 186 SPDQSEHTDGHTSVQSVIE--------------KLQEENRLLKQKVTHVEDLNAKWQRYN 231 ++E D +Q+ +E KL ++ L ++ ++L + R Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338 Query: 232 ASRDEYVRGLHAQLRGLQIPHEPEL-----MRKEISRLNRQL---EEKINDCAEVKQELA 283 + +R L + LQ + E+ + + IS LN QL ++K+ D A + L Sbjct: 1339 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1398 Query: 284 ASRTARDAALERV-QMLEQQILAYKDDFMSERADRERAQSRI-QELEEKVASLLHQ 337 + +E + Q E++ AY E+ ++R+ QEL++ V L +Q Sbjct: 1399 EGKKRFQKEIENLTQQYEEKAAAYD--------KLEKTKNRLQQELDDLVVDLDNQ 1446 Score = 41.2 bits (95), Expect = 0.002 Identities = 56/276 (20%), Positives = 110/276 (39%), Gaps = 45/276 (16%) Query: 32 RRLQDQLAARDALIARLRA---RLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEA 88 R L+D A+RD + A + + +LE D D + AR + L ++E A Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725 Query: 89 --------------QMRQEIERLTERLEEKEREMQQL------LSQPQHEREKEVVLLRR 128 ++ I +L E LEE++ M+ + +Q + E+ R Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785 Query: 129 SMAEGERARAASDVLCRSLANETHQL--------RRTLTATAHMCQHLAKCLD----ERQ 176 + + E AR + + L ++ H++ + T+ A L + ++ E+Q Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845 Query: 177 HAQRNVGERSPDQSEHT----DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNA 232 A +++ ++ E D + E+ ++ N +KQ +E+ + QR NA Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905 Query: 233 SRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQL 268 +R + R L + E M +E++ L +L Sbjct: 1906 NRRKLQRELD------EATESNEAMGREVNALKSKL 1935 Score = 29.6 bits (65), Expect = 5.5 Identities = 17/77 (22%), Positives = 39/77 (50%) Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRI 352 L +V E+++ A +D+ + +++A++ ++ELE+K + L + + Q+ + + Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910 Query: 353 HAGSKTAKYLAADALEL 369 + LAA EL Sbjct: 911 AEAEEMRVRLAAKKQEL 927 >gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo sapiens] Length = 1945 Score = 59.7 bits (143), Expect = 5e-09 Identities = 88/386 (22%), Positives = 158/386 (40%), Gaps = 47/386 (12%) Query: 2 SRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAP 61 S+D E ++ AL T E +L L+D+L A + RL + AL+G Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585 Query: 62 SLVDALLEQVARFREQLRRQEGGAAEAQMRQEIER--------LTERLEEKEREMQQLLS 113 L A EQ R QL+RQ E + E ER ++LE ++++ Sbjct: 1586 DL-QARDEQNEEKRRQLQRQ---LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1641 Query: 114 QPQHEREKEVVLLRRSMA-------EGERARAASDVLCRSLANETHQLRRTLTATAHMCQ 166 RE+ + LR+ A E E ARA+ D + + A E + ++L A Q Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF-ATAKENEKKAKSLEADLMQLQ 1700 Query: 167 H-LAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225 LA R+ A E + + + G + LQ+E R L+ ++ +E+ Sbjct: 1701 EDLAAAERARKQADLEKEELAEELASSLSGRNA-------LQDEKRRLEARIAQLEEELE 1753 Query: 226 KWQRYNASRDEYVRGLHAQLRGL--------QIPHEPELMRKEISRLNRQLEEKINDC-A 276 + Q + + VR Q L + E R+++ R N++L K+++ Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1813 Query: 277 EVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336 VK + ++ A +A ++ LE+Q+ E +++ A +++ ++K+ +L Sbjct: 1814 AVKSKFKSTIAALEA---KIAQLEEQV-------EQEAREKQAATKSLKQKDKKLKEILL 1863 Query: 337 QVSWRQDSREPDAGRIHAGSKTAKYL 362 QV + E + G+ K L Sbjct: 1864 QVEDERKMAEQYKEQAEKGNARVKQL 1889 Score = 52.8 bits (125), Expect = 6e-07 Identities = 72/362 (19%), Positives = 153/362 (42%), Gaps = 39/362 (10%) Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPS-------- 62 +E R + T + + LQDQL L ++ L + S Sbjct: 1332 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391 Query: 63 -LVDALLEQVARFREQLRR-----QEGGAA-------EAQMRQEIE----------RLTE 99 V+AL E RF++++ +E AA + +++QE++ +L Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451 Query: 100 RLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLT 159 LE+K+R+ QLL++ ++ K R+ AE + L R+L E + + L Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL-EEALEAKEELE 1510 Query: 160 ATAHMCQ-HLAKCLDERQHAQRNVGERSPD----QSEHTDGHTSVQSVIEKLQEENRLLK 214 T M + + + + +NV E +++ + T ++ + ++LQ Sbjct: 1511 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1570 Query: 215 QKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPEL--MRKEISRLNRQLEEKI 272 + +++ L +++R +RDE QL+ +E EL RK+ + ++ Sbjct: 1571 RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1630 Query: 273 NDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVA 332 D +++ + ++ R+ A+++++ L+ Q+ ++ + RA R+ + +E E+K Sbjct: 1631 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1690 Query: 333 SL 334 SL Sbjct: 1691 SL 1692 Score = 51.6 bits (122), Expect = 1e-06 Identities = 65/266 (24%), Positives = 122/266 (45%), Gaps = 24/266 (9%) Query: 85 AAEAQMRQEI-ERLTERLEEKEREMQQLLSQPQHEREK---EVVLLRRSMAEGERARAAS 140 AA+ Q +EI + RLEE+E QQL Q ER+K +++ L + E E AR Sbjct: 921 AAKKQELEEILHEMEARLEEEEDRGQQL----QAERKKMAQQMLDLEEQLEEEEAAR--- 973 Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQ 200 + QL + +TA A + + + L + ER + +D T++ Sbjct: 974 ---------QKLQLEK-VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1023 Query: 201 SVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPEL--MR 258 EK + +L + + + +L + ++ SR E + L +L G ++ ++ Sbjct: 1024 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKLEGDASDFHEQIADLQ 1082 Query: 259 KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRE 318 +I+ L QL +K + L ++ AL++++ LE I ++D SERA R Sbjct: 1083 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1142 Query: 319 RAQSRIQELEEKVASLLHQVSWRQDS 344 +A+ + ++L E++ +L ++ DS Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTLDS 1168 Score = 47.4 bits (111), Expect = 3e-05 Identities = 75/356 (21%), Positives = 148/356 (41%), Gaps = 61/356 (17%) Query: 31 LRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG------ 84 L RL D++A ++ + ++R LEG + D E+ AR + + ++++ G Sbjct: 1103 LARLDDEIAQKNNALKKIRE----LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1158 Query: 85 -----------AAEAQMR----QEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRS 129 A + ++R QE+ L + L+E+ R + + + + + + V L Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218 Query: 130 MAEGERARAASDVLCRSLANETHQLR---RTLTATAHMCQHLAKCLDER-QHAQRNVGER 185 + + +RA+A D ++L E L R L +H K L+ + Q Q + Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278 Query: 186 SPDQSEHTDGHTSVQSVIE--------------KLQEENRLLKQKVTHVEDLNAKWQRYN 231 ++E D +Q+ +E KL ++ L ++ ++L + R Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338 Query: 232 ASRDEYVRGLHAQLRGLQIPHEPEL-----MRKEISRLNRQL---EEKINDCAEVKQELA 283 + +R L + LQ + E+ + + IS LN QL ++K+ D A + L Sbjct: 1339 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1398 Query: 284 ASRTARDAALERV-QMLEQQILAYKDDFMSERADRERAQSRI-QELEEKVASLLHQ 337 + +E + Q E++ AY E+ ++R+ QEL++ V L +Q Sbjct: 1399 EGKKRFQKEIENLTQQYEEKAAAYD--------KLEKTKNRLQQELDDLVVDLDNQ 1446 Score = 41.2 bits (95), Expect = 0.002 Identities = 56/276 (20%), Positives = 110/276 (39%), Gaps = 45/276 (16%) Query: 32 RRLQDQLAARDALIARLRA---RLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEA 88 R L+D A+RD + A + + +LE D D + AR + L ++E A Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725 Query: 89 --------------QMRQEIERLTERLEEKEREMQQL------LSQPQHEREKEVVLLRR 128 ++ I +L E LEE++ M+ + +Q + E+ R Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785 Query: 129 SMAEGERARAASDVLCRSLANETHQL--------RRTLTATAHMCQHLAKCLD----ERQ 176 + + E AR + + L ++ H++ + T+ A L + ++ E+Q Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845 Query: 177 HAQRNVGERSPDQSEHT----DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNA 232 A +++ ++ E D + E+ ++ N +KQ +E+ + QR NA Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905 Query: 233 SRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQL 268 +R + R L + E M +E++ L +L Sbjct: 1906 NRRKLQRELD------EATESNEAMGREVNALKSKL 1935 Score = 29.6 bits (65), Expect = 5.5 Identities = 17/77 (22%), Positives = 39/77 (50%) Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRI 352 L +V E+++ A +D+ + +++A++ ++ELE+K + L + + Q+ + + Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910 Query: 353 HAGSKTAKYLAADALEL 369 + LAA EL Sbjct: 911 AEAEEMRVRLAAKKQEL 927 >gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo sapiens] Length = 1938 Score = 59.7 bits (143), Expect = 5e-09 Identities = 88/386 (22%), Positives = 158/386 (40%), Gaps = 47/386 (12%) Query: 2 SRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAP 61 S+D E ++ AL T E +L L+D+L A + RL + AL+G Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578 Query: 62 SLVDALLEQVARFREQLRRQEGGAAEAQMRQEIER--------LTERLEEKEREMQQLLS 113 L A EQ R QL+RQ E + E ER ++LE ++++ Sbjct: 1579 DL-QARDEQNEEKRRQLQRQ---LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1634 Query: 114 QPQHEREKEVVLLRRSMA-------EGERARAASDVLCRSLANETHQLRRTLTATAHMCQ 166 RE+ + LR+ A E E ARA+ D + + A E + ++L A Q Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF-ATAKENEKKAKSLEADLMQLQ 1693 Query: 167 H-LAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225 LA R+ A E + + + G + LQ+E R L+ ++ +E+ Sbjct: 1694 EDLAAAERARKQADLEKEELAEELASSLSGRNA-------LQDEKRRLEARIAQLEEELE 1746 Query: 226 KWQRYNASRDEYVRGLHAQLRGL--------QIPHEPELMRKEISRLNRQLEEKINDC-A 276 + Q + + VR Q L + E R+++ R N++L K+++ Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1806 Query: 277 EVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336 VK + ++ A +A ++ LE+Q+ E +++ A +++ ++K+ +L Sbjct: 1807 AVKSKFKSTIAALEA---KIAQLEEQV-------EQEAREKQAATKSLKQKDKKLKEILL 1856 Query: 337 QVSWRQDSREPDAGRIHAGSKTAKYL 362 QV + E + G+ K L Sbjct: 1857 QVEDERKMAEQYKEQAEKGNARVKQL 1882 Score = 52.8 bits (125), Expect = 6e-07 Identities = 72/362 (19%), Positives = 153/362 (42%), Gaps = 39/362 (10%) Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPS-------- 62 +E R + T + + LQDQL L ++ L + S Sbjct: 1325 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1384 Query: 63 -LVDALLEQVARFREQLRR-----QEGGAA-------EAQMRQEIE----------RLTE 99 V+AL E RF++++ +E AA + +++QE++ +L Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444 Query: 100 RLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLT 159 LE+K+R+ QLL++ ++ K R+ AE + L R+L E + + L Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL-EEALEAKEELE 1503 Query: 160 ATAHMCQ-HLAKCLDERQHAQRNVGERSPD----QSEHTDGHTSVQSVIEKLQEENRLLK 214 T M + + + + +NV E +++ + T ++ + ++LQ Sbjct: 1504 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1563 Query: 215 QKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPEL--MRKEISRLNRQLEEKI 272 + +++ L +++R +RDE QL+ +E EL RK+ + ++ Sbjct: 1564 RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1623 Query: 273 NDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVA 332 D +++ + ++ R+ A+++++ L+ Q+ ++ + RA R+ + +E E+K Sbjct: 1624 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1683 Query: 333 SL 334 SL Sbjct: 1684 SL 1685 Score = 51.6 bits (122), Expect = 1e-06 Identities = 65/266 (24%), Positives = 122/266 (45%), Gaps = 24/266 (9%) Query: 85 AAEAQMRQEI-ERLTERLEEKEREMQQLLSQPQHEREK---EVVLLRRSMAEGERARAAS 140 AA+ Q +EI + RLEE+E QQL Q ER+K +++ L + E E AR Sbjct: 914 AAKKQELEEILHEMEARLEEEEDRGQQL----QAERKKMAQQMLDLEEQLEEEEAAR--- 966 Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQ 200 + QL + +TA A + + + L + ER + +D T++ Sbjct: 967 ---------QKLQLEK-VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1016 Query: 201 SVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPEL--MR 258 EK + +L + + + +L + ++ SR E + L +L G ++ ++ Sbjct: 1017 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKLEGDASDFHEQIADLQ 1075 Query: 259 KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRE 318 +I+ L QL +K + L ++ AL++++ LE I ++D SERA R Sbjct: 1076 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1135 Query: 319 RAQSRIQELEEKVASLLHQVSWRQDS 344 +A+ + ++L E++ +L ++ DS Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTLDS 1161 Score = 47.4 bits (111), Expect = 3e-05 Identities = 75/356 (21%), Positives = 148/356 (41%), Gaps = 61/356 (17%) Query: 31 LRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG------ 84 L RL D++A ++ + ++R LEG + D E+ AR + + ++++ G Sbjct: 1096 LARLDDEIAQKNNALKKIRE----LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1151 Query: 85 -----------AAEAQMR----QEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRS 129 A + ++R QE+ L + L+E+ R + + + + + + V L Sbjct: 1152 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1211 Query: 130 MAEGERARAASDVLCRSLANETHQLR---RTLTATAHMCQHLAKCLDER-QHAQRNVGER 185 + + +RA+A D ++L E L R L +H K L+ + Q Q + Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271 Query: 186 SPDQSEHTDGHTSVQSVIE--------------KLQEENRLLKQKVTHVEDLNAKWQRYN 231 ++E D +Q+ +E KL ++ L ++ ++L + R Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331 Query: 232 ASRDEYVRGLHAQLRGLQIPHEPEL-----MRKEISRLNRQL---EEKINDCAEVKQELA 283 + +R L + LQ + E+ + + IS LN QL ++K+ D A + L Sbjct: 1332 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1391 Query: 284 ASRTARDAALERV-QMLEQQILAYKDDFMSERADRERAQSRI-QELEEKVASLLHQ 337 + +E + Q E++ AY E+ ++R+ QEL++ V L +Q Sbjct: 1392 EGKKRFQKEIENLTQQYEEKAAAYD--------KLEKTKNRLQQELDDLVVDLDNQ 1439 Score = 41.2 bits (95), Expect = 0.002 Identities = 56/276 (20%), Positives = 110/276 (39%), Gaps = 45/276 (16%) Query: 32 RRLQDQLAARDALIARLRA---RLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEA 88 R L+D A+RD + A + + +LE D D + AR + L ++E A Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718 Query: 89 --------------QMRQEIERLTERLEEKEREMQQL------LSQPQHEREKEVVLLRR 128 ++ I +L E LEE++ M+ + +Q + E+ R Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778 Query: 129 SMAEGERARAASDVLCRSLANETHQL--------RRTLTATAHMCQHLAKCLD----ERQ 176 + + E AR + + L ++ H++ + T+ A L + ++ E+Q Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838 Query: 177 HAQRNVGERSPDQSEHT----DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNA 232 A +++ ++ E D + E+ ++ N +KQ +E+ + QR NA Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898 Query: 233 SRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQL 268 +R + R L + E M +E++ L +L Sbjct: 1899 NRRKLQRELD------EATESNEAMGREVNALKSKL 1928 Score = 29.6 bits (65), Expect = 5.5 Identities = 17/77 (22%), Positives = 39/77 (50%) Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRI 352 L +V E+++ A +D+ + +++A++ ++ELE+K + L + + Q+ + + Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903 Query: 353 HAGSKTAKYLAADALEL 369 + LAA EL Sbjct: 904 AEAEEMRVRLAAKKQEL 920 >gi|31982906 cingulin-like 1 [Homo sapiens] Length = 1302 Score = 59.7 bits (143), Expect = 5e-09 Identities = 71/329 (21%), Positives = 149/329 (45%), Gaps = 34/329 (10%) Query: 23 LYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSL-----VDALLEQVARFREQ 77 L E ++L+ ++L R +A+L+ ++ L+GD A + + + Q+ Sbjct: 826 LLQEENEKLQGRSEELERR---VAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVH 882 Query: 78 LRRQEGGAAEAQ--MRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLR-RSMAEGE 134 R++E A A+ + E+E L + +E +QL + + E E++ L R ++ E E Sbjct: 883 ARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENE 942 Query: 135 RARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE-RQHAQRNVGERSPDQSEHT 193 R L +++ ++ + A+ L LDE ++ +R + E E T Sbjct: 943 RWH-----LGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKT 997 Query: 194 DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRG---LHAQLRGLQI 250 + K+Q+E RL+++++ + Y ++DE + L L+ L+ Sbjct: 998 LEAEKSRLTAMKMQDEMRLMEEEL----------RDYQRAQDEALTKRQLLEQTLKDLEY 1047 Query: 251 PHEPEL-MRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDD 309 E + ++ + SRL +Q+E+K++ +++ EL R D ER+ +Q+ +++ Sbjct: 1048 ELEAKSHLKDDRSRLVKQMEDKVS---QLEMELEEERNNSDLLSERISRSREQMEQLRNE 1104 Query: 310 FMSERADRERAQSRIQELEEKVASLLHQV 338 + ERA R+ + LE + L ++ Sbjct: 1105 LLQERAARQDLECDKISLERQNKDLKSRI 1133 Score = 57.4 bits (137), Expect = 2e-08 Identities = 82/389 (21%), Positives = 168/389 (43%), Gaps = 52/389 (13%) Query: 23 LYHEAGQRLRRLQDQLAARDALIARLRAR---LAALEGDAAPSLVDALLEQVARFREQLR 79 L E Q + LQD L A++ LR R L AL+G AL E+V+ +++ Sbjct: 728 LIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKG--------ALKEEVSSHDQEMD 779 Query: 80 R-QEGGAAEAQ-MRQEIERLTERLE------------EKEREMQQLLSQPQHER------ 119 + +E AE Q +R+ +E T+ +E + EM+ L Q ++E+ Sbjct: 780 KLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSE 839 Query: 120 --EKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCL----D 173 E+ V L+R + + + A + + E QL L + + Sbjct: 840 ELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALEN 899 Query: 174 ERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNAS 233 E + AQ N+ + + +Q + ++ E+L+ ++ + H+ K Q+ A Sbjct: 900 ELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMAD 959 Query: 234 RDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAE--------------VK 279 E R +L+ Q+ E R+E++ + RQL+EK + + ++ Sbjct: 960 IVEASRTSTLELQN-QLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLME 1018 Query: 280 QELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339 +EL + A+D AL + Q+LEQ + + + ++ ++ ++++E+KV+ L ++ Sbjct: 1019 EELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELE 1078 Query: 340 WRQDSREPDAGRIHAGSKTAKYLAADALE 368 +++ + + RI + + L + L+ Sbjct: 1079 EERNNSDLLSERISRSREQMEQLRNELLQ 1107 Score = 32.7 bits (73), Expect = 0.65 Identities = 62/295 (21%), Positives = 113/295 (38%), Gaps = 39/295 (13%) Query: 69 EQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQP-----QHEREKEV 123 + V R +L+ GA+ A R + ++ E E + + + Q ++E+EV Sbjct: 438 QSVGRTFAKLQGAAHGASCAHSRPPQPNIDGKVLETEGSQESTVIRAPSLGAQSKKEEEV 497 Query: 124 VLLRRSMAEGERARAAS-DVLCRSLANETHQLRRTLTATAHMC---QHLAKCLDE---RQ 176 ++ RA A S D + ++ +T AT + Q L + +E +Q Sbjct: 498 KTATATLMLQNRATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQ 557 Query: 177 HAQRNVGERSPDQSEHTDGHTSVQSVIEKLQ----------EENRLLKQKVTHVEDLNAK 226 + E S D + T V V EK+Q + N + V+DL + Sbjct: 558 ILYNYLKEGSTDNDDATK--RKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQ 615 Query: 227 WQRYNASRDEYVRGLHAQLRGLQ-IPHEPELMR--------------KEISRLNRQLEEK 271 + E R L +++ Q I E E MR +E S L ++LEE Sbjct: 616 KSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEES 675 Query: 272 INDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326 + + +EL + R+ ++ L+ Q+ D+ S + +R + + E Sbjct: 676 EGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIE 730 Score = 30.0 bits (66), Expect = 4.2 Identities = 34/141 (24%), Positives = 62/141 (43%), Gaps = 24/141 (17%) Query: 89 QMRQEIERLTERLEEKEREMQQL-LSQPQHERE-KEVVLLRRSMAEGERARAASDVLCRS 146 QM I L +RLE +ER+ L LS + ER+ KE+V+ + E S Sbjct: 1150 QMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVM----QVDDEHL---------S 1196 Query: 147 LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG---ERSPDQSEHTDGHTSVQSVI 203 L ++ QL L A + + +D + +++ + E D +EH G + Sbjct: 1197 LTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQ------L 1250 Query: 204 EKLQEENRLLKQKVTHVEDLN 224 ++++ RL K ++D++ Sbjct: 1251 NSMKKDLRLKKLPSKVLDDMD 1271 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.129 0.369 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,045,257 Number of Sequences: 37866 Number of extensions: 812509 Number of successful extensions: 10821 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 162 Number of HSP's successfully gapped in prelim test: 795 Number of HSP's that attempted gapping in prelim test: 6520 Number of HSP's gapped (non-prelim): 3020 length of query: 429 length of database: 18,247,518 effective HSP length: 105 effective length of query: 324 effective length of database: 14,271,588 effective search space: 4623994512 effective search space used: 4623994512 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.