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Search of human proteins with 239787092
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239787092 A20-binding inhibitor of NF-kappaB activation 2
isoform 1 [Homo sapiens]
(429 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239787092 A20-binding inhibitor of NF-kappaB activation 2 iso... 853 0.0
gi|239787094 A20-binding inhibitor of NF-kappaB activation 2 iso... 650 0.0
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 68 2e-11
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 68 2e-11
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 68 2e-11
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 64 3e-10
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 62 8e-10
gi|223671870 inhibitor of kappa light polypeptide gene enhancer ... 62 8e-10
gi|4504631 inhibitor of kappa light polypeptide gene enhancer in... 62 8e-10
gi|153792133 inhibitor of kappa light polypeptide gene enhancer ... 62 8e-10
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 62 1e-09
gi|126723390 ankyrin repeat domain 24 [Homo sapiens] 62 1e-09
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 61 2e-09
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 61 2e-09
gi|121582655 ankyrin repeat domain 35 [Homo sapiens] 61 2e-09
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 60 3e-09
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 60 3e-09
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 60 3e-09
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 60 3e-09
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 60 3e-09
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 60 3e-09
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 60 3e-09
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 60 3e-09
gi|148746195 trichohyalin [Homo sapiens] 60 4e-09
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 60 5e-09
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 60 5e-09
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 60 5e-09
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 60 5e-09
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 60 5e-09
gi|31982906 cingulin-like 1 [Homo sapiens] 60 5e-09
>gi|239787092 A20-binding inhibitor of NF-kappaB activation 2
isoform 1 [Homo sapiens]
Length = 429
Score = 853 bits (2203), Expect = 0.0
Identities = 429/429 (100%), Positives = 429/429 (100%)
Query: 1 MSRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAA 60
MSRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAA
Sbjct: 1 MSRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAA 60
Query: 61 PSLVDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHERE 120
PSLVDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHERE
Sbjct: 61 PSLVDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHERE 120
Query: 121 KEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQR 180
KEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQR
Sbjct: 121 KEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQR 180
Query: 181 NVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRG 240
NVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRG
Sbjct: 181 NVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRG 240
Query: 241 LHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLE 300
LHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLE
Sbjct: 241 LHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLE 300
Query: 301 QQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360
QQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK
Sbjct: 301 QQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360
Query: 361 YLAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPHCLQCFSDEQGEEL 420
YLAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPHCLQCFSDEQGEEL
Sbjct: 361 YLAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPHCLQCFSDEQGEEL 420
Query: 421 LRHVAECCQ 429
LRHVAECCQ
Sbjct: 421 LRHVAECCQ 429
>gi|239787094 A20-binding inhibitor of NF-kappaB activation 2
isoform 2 [Homo sapiens]
Length = 322
Score = 650 bits (1676), Expect = 0.0
Identities = 322/322 (100%), Positives = 322/322 (100%)
Query: 108 MQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQH 167
MQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQH
Sbjct: 1 MQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQH 60
Query: 168 LAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW 227
LAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW
Sbjct: 61 LAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW 120
Query: 228 QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287
QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT
Sbjct: 121 QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 180
Query: 288 ARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREP 347
ARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREP
Sbjct: 181 ARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREP 240
Query: 348 DAGRIHAGSKTAKYLAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPH 407
DAGRIHAGSKTAKYLAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPH
Sbjct: 241 DAGRIHAGSKTAKYLAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPH 300
Query: 408 CLQCFSDEQGEELLRHVAECCQ 429
CLQCFSDEQGEELLRHVAECCQ
Sbjct: 301 CLQCFSDEQGEELLRHVAECCQ 322
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 67.8 bits (164), Expect = 2e-11
Identities = 84/358 (23%), Positives = 148/358 (41%), Gaps = 29/358 (8%)
Query: 15 RAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARF 74
RA L T + + RR +++ A +A R AA E +A + E V R
Sbjct: 1386 RAGRELQTAQAQLSEWRRRQEEEAGALEA--GEEARRRAAREAEALTQRLAEKTETVDRL 1443
Query: 75 REQLRRQEGGAAEAQMRQEIER-LTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG 133
RR + +A M E +R L LE+K+R+ QLL++ + + V R+ AEG
Sbjct: 1444 ERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEG 1503
Query: 134 ERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHT 193
A + L R+L E + L L + ++V E
Sbjct: 1504 REREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHE--------- 1554
Query: 194 DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
++ ++ L+ +VT +ED A+ D +R L ++ L+ HE
Sbjct: 1555 -----LERACRVAEQAANDLRAQVTELED------ELTAAEDAKLR-LEVTVQALKTQHE 1602
Query: 254 PELMRKEIS--RLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFM 311
+L ++ + RQL +++ D AEV+++ R R A+ + LE ++ K
Sbjct: 1603 RDLQGRDEAGEERRRQLAKQLRD-AEVERD--EERKQRTLAVAARKKLEGELEELKAQMA 1659
Query: 312 SERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALEL 369
S +E A ++++++ ++ L +V + SRE + K K L A+ L L
Sbjct: 1660 SAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRL 1717
Score = 60.8 bits (146), Expect = 2e-09
Identities = 79/361 (21%), Positives = 154/361 (42%), Gaps = 54/361 (14%)
Query: 34 LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEAQMRQE 93
LQ+Q+ + LRA+L E + +L A E AR + +E AA A+ +++
Sbjct: 1092 LQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQED 1151
Query: 94 IER--------------LTERLEEKEREMQQLL------SQPQHEREKEVVLLRRSMAEG 133
+E L E LE E++ L + + +RE+EV L++++ E
Sbjct: 1152 LESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEE 1211
Query: 134 ERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG-------ERS 186
R A+ +LR+ Q L + ++ + A+R G
Sbjct: 1212 TRIHEAA----------VQELRQ------RHGQALGELAEQLEQARRGKGAWEKTRLALE 1255
Query: 187 PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246
+ SE +S+Q+ ++ ++ R L+ ++ V+ +R A E ++ A+L
Sbjct: 1256 AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE 1315
Query: 247 GLQ-IPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILA 305
+ +E E +S+ E +++D E+ QE ++ A + RV+ +E +
Sbjct: 1316 NVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS---RVRAMEAEAAG 1372
Query: 306 YKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAAD 365
++ E A RERA +Q + +++ WR+ +E +AG + AG + + A +
Sbjct: 1373 LREQLEEEAAARERAGRELQTAQAQLS------EWRR-RQEEEAGALEAGEEARRRAARE 1425
Query: 366 A 366
A
Sbjct: 1426 A 1426
Score = 60.1 bits (144), Expect = 4e-09
Identities = 71/308 (23%), Positives = 134/308 (43%), Gaps = 27/308 (8%)
Query: 71 VARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSM 130
+A ++LR++E G RQE+E+L RL+ + E+Q+ + + Q E+ L R
Sbjct: 1061 IADMEDRLRKEEKG------RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKE 1114
Query: 131 AEGERARAASDVLCRSLANETHQLRRTLTATAHM-----CQHLAKCLDERQHAQRNVGER 185
E + A A ++ + A LR A A + +A+ E+Q +R++GE
Sbjct: 1115 EELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQ--RRDLGEE 1172
Query: 186 SP---DQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLH 242
+ E T T+ Q + +E Q+VT ++ + R + + + +R H
Sbjct: 1173 LEALRGELEDTLDSTNAQQELRSKRE------QEVTELKKTLEEETRIHEAAVQELRQRH 1226
Query: 243 AQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQ 302
Q G ++ + E R+ + + +E++ EL++ +TAR +R + LE Q
Sbjct: 1227 GQALG-ELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQ 1285
Query: 303 ILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYL 362
+ + D ERA++ E ++ + L VS + E R+ + +
Sbjct: 1286 L----QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ 1341
Query: 363 AADALELM 370
DA EL+
Sbjct: 1342 LHDAQELL 1349
Score = 50.4 bits (119), Expect = 3e-06
Identities = 75/331 (22%), Positives = 139/331 (41%), Gaps = 46/331 (13%)
Query: 29 QRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEA 88
Q+++ LQ Q A + L+ R+A LE E+ AR EQLR + AEA
Sbjct: 887 QKVQELQQQSARE---VGELQGRVAQLE------------EERARLAEQLRAEAELCAEA 931
Query: 89 Q--------MRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAAS 140
+ +QE+E + LE + E ++ Q Q E+++ ++ A E A
Sbjct: 932 EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGAR 991
Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQ 200
L ++++ + +K ER+ + + E S +E
Sbjct: 992 QKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEE------- 1044
Query: 201 SVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKE 260
EK++ N+L + + D+ + ++ R E + L +L G E ++++
Sbjct: 1045 ---EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE-LEKLKRRLDG-----ESSELQEQ 1095
Query: 261 ISRLNRQLEEKINDCAEVKQEL-AASRTARDAALERVQMLE-----QQILA-YKDDFMSE 313
+ ++ EE ++EL AA A D R Q+L+ Q LA ++D SE
Sbjct: 1096 MVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESE 1155
Query: 314 RADRERAQSRIQELEEKVASLLHQVSWRQDS 344
R R +A+ + ++L E++ +L ++ DS
Sbjct: 1156 RVARTKAEKQRRDLGEELEALRGELEDTLDS 1186
Score = 46.2 bits (108), Expect = 6e-05
Identities = 79/369 (21%), Positives = 145/369 (39%), Gaps = 59/369 (15%)
Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEG------DAAPSLV 64
EE RA A A R L+++ AR+ L + RA A LE D S+
Sbjct: 1494 EERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVH 1553
Query: 65 DALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKER-EMQQLLSQPQHEREKEV 123
+ LE+ R EQ AQ+ + + LT + K R E+ + QHER+ +
Sbjct: 1554 E--LERACRVAEQAAND----LRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQG 1607
Query: 124 VLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG 183
R E R + A + + + + +RTL A R+ + +
Sbjct: 1608 ---RDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAA------------RKKLEGELE 1652
Query: 184 ERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHA 243
E + G + K+Q + + L ++V + N ++ ++GL A
Sbjct: 1653 ELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEA 1712
Query: 244 QLRGLQ------------IPHEPELMRKEISRLN----------RQLEEKINDCAEVKQE 281
++ LQ + + M E++ N RQLE ++ ++++E
Sbjct: 1713 EVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLG---QLEEE 1769
Query: 282 LAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWR 341
L ++ + +R + L Q+ + + +ER+ +A+S Q+LE ++ L ++
Sbjct: 1770 LEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLG-- 1827
Query: 342 QDSREPDAG 350
E DAG
Sbjct: 1828 ----EEDAG 1832
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 67.8 bits (164), Expect = 2e-11
Identities = 84/358 (23%), Positives = 148/358 (41%), Gaps = 29/358 (8%)
Query: 15 RAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARF 74
RA L T + + RR +++ A +A R AA E +A + E V R
Sbjct: 1378 RAGRELQTAQAQLSEWRRRQEEEAGALEA--GEEARRRAAREAEALTQRLAEKTETVDRL 1435
Query: 75 REQLRRQEGGAAEAQMRQEIER-LTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG 133
RR + +A M E +R L LE+K+R+ QLL++ + + V R+ AEG
Sbjct: 1436 ERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEG 1495
Query: 134 ERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHT 193
A + L R+L E + L L + ++V E
Sbjct: 1496 REREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHE--------- 1546
Query: 194 DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
++ ++ L+ +VT +ED A+ D +R L ++ L+ HE
Sbjct: 1547 -----LERACRVAEQAANDLRAQVTELED------ELTAAEDAKLR-LEVTVQALKTQHE 1594
Query: 254 PELMRKEIS--RLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFM 311
+L ++ + RQL +++ D AEV+++ R R A+ + LE ++ K
Sbjct: 1595 RDLQGRDEAGEERRRQLAKQLRD-AEVERD--EERKQRTLAVAARKKLEGELEELKAQMA 1651
Query: 312 SERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALEL 369
S +E A ++++++ ++ L +V + SRE + K K L A+ L L
Sbjct: 1652 SAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRL 1709
Score = 60.8 bits (146), Expect = 2e-09
Identities = 79/361 (21%), Positives = 154/361 (42%), Gaps = 54/361 (14%)
Query: 34 LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEAQMRQE 93
LQ+Q+ + LRA+L E + +L A E AR + +E AA A+ +++
Sbjct: 1084 LQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQED 1143
Query: 94 IER--------------LTERLEEKEREMQQLL------SQPQHEREKEVVLLRRSMAEG 133
+E L E LE E++ L + + +RE+EV L++++ E
Sbjct: 1144 LESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEE 1203
Query: 134 ERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG-------ERS 186
R A+ +LR+ Q L + ++ + A+R G
Sbjct: 1204 TRIHEAA----------VQELRQ------RHGQALGELAEQLEQARRGKGAWEKTRLALE 1247
Query: 187 PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246
+ SE +S+Q+ ++ ++ R L+ ++ V+ +R A E ++ A+L
Sbjct: 1248 AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE 1307
Query: 247 GLQ-IPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILA 305
+ +E E +S+ E +++D E+ QE ++ A + RV+ +E +
Sbjct: 1308 NVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS---RVRAMEAEAAG 1364
Query: 306 YKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAAD 365
++ E A RERA +Q + +++ WR+ +E +AG + AG + + A +
Sbjct: 1365 LREQLEEEAAARERAGRELQTAQAQLS------EWRR-RQEEEAGALEAGEEARRRAARE 1417
Query: 366 A 366
A
Sbjct: 1418 A 1418
Score = 60.1 bits (144), Expect = 4e-09
Identities = 71/308 (23%), Positives = 134/308 (43%), Gaps = 27/308 (8%)
Query: 71 VARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSM 130
+A ++LR++E G RQE+E+L RL+ + E+Q+ + + Q E+ L R
Sbjct: 1053 IADMEDRLRKEEKG------RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKE 1106
Query: 131 AEGERARAASDVLCRSLANETHQLRRTLTATAHM-----CQHLAKCLDERQHAQRNVGER 185
E + A A ++ + A LR A A + +A+ E+Q +R++GE
Sbjct: 1107 EELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQ--RRDLGEE 1164
Query: 186 SP---DQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLH 242
+ E T T+ Q + +E Q+VT ++ + R + + + +R H
Sbjct: 1165 LEALRGELEDTLDSTNAQQELRSKRE------QEVTELKKTLEEETRIHEAAVQELRQRH 1218
Query: 243 AQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQ 302
Q G ++ + E R+ + + +E++ EL++ +TAR +R + LE Q
Sbjct: 1219 GQALG-ELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQ 1277
Query: 303 ILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYL 362
+ + D ERA++ E ++ + L VS + E R+ + +
Sbjct: 1278 L----QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ 1333
Query: 363 AADALELM 370
DA EL+
Sbjct: 1334 LHDAQELL 1341
Score = 50.4 bits (119), Expect = 3e-06
Identities = 75/331 (22%), Positives = 139/331 (41%), Gaps = 46/331 (13%)
Query: 29 QRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEA 88
Q+++ LQ Q A + L+ R+A LE E+ AR EQLR + AEA
Sbjct: 879 QKVQELQQQSARE---VGELQGRVAQLE------------EERARLAEQLRAEAELCAEA 923
Query: 89 Q--------MRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAAS 140
+ +QE+E + LE + E ++ Q Q E+++ ++ A E A
Sbjct: 924 EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGAR 983
Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQ 200
L ++++ + +K ER+ + + E S +E
Sbjct: 984 QKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEE------- 1036
Query: 201 SVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKE 260
EK++ N+L + + D+ + ++ R E + L +L G E ++++
Sbjct: 1037 ---EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE-LEKLKRRLDG-----ESSELQEQ 1087
Query: 261 ISRLNRQLEEKINDCAEVKQEL-AASRTARDAALERVQMLE-----QQILA-YKDDFMSE 313
+ ++ EE ++EL AA A D R Q+L+ Q LA ++D SE
Sbjct: 1088 MVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESE 1147
Query: 314 RADRERAQSRIQELEEKVASLLHQVSWRQDS 344
R R +A+ + ++L E++ +L ++ DS
Sbjct: 1148 RVARTKAEKQRRDLGEELEALRGELEDTLDS 1178
Score = 46.2 bits (108), Expect = 6e-05
Identities = 79/369 (21%), Positives = 145/369 (39%), Gaps = 59/369 (15%)
Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEG------DAAPSLV 64
EE RA A A R L+++ AR+ L + RA A LE D S+
Sbjct: 1486 EERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVH 1545
Query: 65 DALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKER-EMQQLLSQPQHEREKEV 123
+ LE+ R EQ AQ+ + + LT + K R E+ + QHER+ +
Sbjct: 1546 E--LERACRVAEQAAND----LRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQG 1599
Query: 124 VLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG 183
R E R + A + + + + +RTL A R+ + +
Sbjct: 1600 ---RDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAA------------RKKLEGELE 1644
Query: 184 ERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHA 243
E + G + K+Q + + L ++V + N ++ ++GL A
Sbjct: 1645 ELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEA 1704
Query: 244 QLRGLQ------------IPHEPELMRKEISRLN----------RQLEEKINDCAEVKQE 281
++ LQ + + M E++ N RQLE ++ ++++E
Sbjct: 1705 EVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLG---QLEEE 1761
Query: 282 LAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWR 341
L ++ + +R + L Q+ + + +ER+ +A+S Q+LE ++ L ++
Sbjct: 1762 LEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLG-- 1819
Query: 342 QDSREPDAG 350
E DAG
Sbjct: 1820 ----EEDAG 1824
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 67.8 bits (164), Expect = 2e-11
Identities = 84/358 (23%), Positives = 148/358 (41%), Gaps = 29/358 (8%)
Query: 15 RAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARF 74
RA L T + + RR +++ A +A R AA E +A + E V R
Sbjct: 1419 RAGRELQTAQAQLSEWRRRQEEEAGALEA--GEEARRRAAREAEALTQRLAEKTETVDRL 1476
Query: 75 REQLRRQEGGAAEAQMRQEIER-LTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG 133
RR + +A M E +R L LE+K+R+ QLL++ + + V R+ AEG
Sbjct: 1477 ERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEG 1536
Query: 134 ERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHT 193
A + L R+L E + L L + ++V E
Sbjct: 1537 REREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHE--------- 1587
Query: 194 DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
++ ++ L+ +VT +ED A+ D +R L ++ L+ HE
Sbjct: 1588 -----LERACRVAEQAANDLRAQVTELED------ELTAAEDAKLR-LEVTVQALKTQHE 1635
Query: 254 PELMRKEIS--RLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFM 311
+L ++ + RQL +++ D AEV+++ R R A+ + LE ++ K
Sbjct: 1636 RDLQGRDEAGEERRRQLAKQLRD-AEVERD--EERKQRTLAVAARKKLEGELEELKAQMA 1692
Query: 312 SERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALEL 369
S +E A ++++++ ++ L +V + SRE + K K L A+ L L
Sbjct: 1693 SAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRL 1750
Score = 60.8 bits (146), Expect = 2e-09
Identities = 79/361 (21%), Positives = 154/361 (42%), Gaps = 54/361 (14%)
Query: 34 LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEAQMRQE 93
LQ+Q+ + LRA+L E + +L A E AR + +E AA A+ +++
Sbjct: 1125 LQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQED 1184
Query: 94 IER--------------LTERLEEKEREMQQLL------SQPQHEREKEVVLLRRSMAEG 133
+E L E LE E++ L + + +RE+EV L++++ E
Sbjct: 1185 LESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEE 1244
Query: 134 ERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG-------ERS 186
R A+ +LR+ Q L + ++ + A+R G
Sbjct: 1245 TRIHEAA----------VQELRQ------RHGQALGELAEQLEQARRGKGAWEKTRLALE 1288
Query: 187 PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246
+ SE +S+Q+ ++ ++ R L+ ++ V+ +R A E ++ A+L
Sbjct: 1289 AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE 1348
Query: 247 GLQ-IPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILA 305
+ +E E +S+ E +++D E+ QE ++ A + RV+ +E +
Sbjct: 1349 NVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS---RVRAMEAEAAG 1405
Query: 306 YKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAAD 365
++ E A RERA +Q + +++ WR+ +E +AG + AG + + A +
Sbjct: 1406 LREQLEEEAAARERAGRELQTAQAQLS------EWRR-RQEEEAGALEAGEEARRRAARE 1458
Query: 366 A 366
A
Sbjct: 1459 A 1459
Score = 60.1 bits (144), Expect = 4e-09
Identities = 71/308 (23%), Positives = 134/308 (43%), Gaps = 27/308 (8%)
Query: 71 VARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSM 130
+A ++LR++E G RQE+E+L RL+ + E+Q+ + + Q E+ L R
Sbjct: 1094 IADMEDRLRKEEKG------RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKE 1147
Query: 131 AEGERARAASDVLCRSLANETHQLRRTLTATAHM-----CQHLAKCLDERQHAQRNVGER 185
E + A A ++ + A LR A A + +A+ E+Q +R++GE
Sbjct: 1148 EELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQ--RRDLGEE 1205
Query: 186 SP---DQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLH 242
+ E T T+ Q + +E Q+VT ++ + R + + + +R H
Sbjct: 1206 LEALRGELEDTLDSTNAQQELRSKRE------QEVTELKKTLEEETRIHEAAVQELRQRH 1259
Query: 243 AQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQ 302
Q G ++ + E R+ + + +E++ EL++ +TAR +R + LE Q
Sbjct: 1260 GQALG-ELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQ 1318
Query: 303 ILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYL 362
+ + D ERA++ E ++ + L VS + E R+ + +
Sbjct: 1319 L----QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ 1374
Query: 363 AADALELM 370
DA EL+
Sbjct: 1375 LHDAQELL 1382
Score = 50.4 bits (119), Expect = 3e-06
Identities = 75/331 (22%), Positives = 139/331 (41%), Gaps = 46/331 (13%)
Query: 29 QRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEA 88
Q+++ LQ Q A + L+ R+A LE E+ AR EQLR + AEA
Sbjct: 920 QKVQELQQQSARE---VGELQGRVAQLE------------EERARLAEQLRAEAELCAEA 964
Query: 89 Q--------MRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAAS 140
+ +QE+E + LE + E ++ Q Q E+++ ++ A E A
Sbjct: 965 EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGAR 1024
Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQ 200
L ++++ + +K ER+ + + E S +E
Sbjct: 1025 QKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEE------- 1077
Query: 201 SVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKE 260
EK++ N+L + + D+ + ++ R E + L +L G E ++++
Sbjct: 1078 ---EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE-LEKLKRRLDG-----ESSELQEQ 1128
Query: 261 ISRLNRQLEEKINDCAEVKQEL-AASRTARDAALERVQMLE-----QQILA-YKDDFMSE 313
+ ++ EE ++EL AA A D R Q+L+ Q LA ++D SE
Sbjct: 1129 MVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESE 1188
Query: 314 RADRERAQSRIQELEEKVASLLHQVSWRQDS 344
R R +A+ + ++L E++ +L ++ DS
Sbjct: 1189 RVARTKAEKQRRDLGEELEALRGELEDTLDS 1219
Score = 46.2 bits (108), Expect = 6e-05
Identities = 79/369 (21%), Positives = 145/369 (39%), Gaps = 59/369 (15%)
Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEG------DAAPSLV 64
EE RA A A R L+++ AR+ L + RA A LE D S+
Sbjct: 1527 EERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVH 1586
Query: 65 DALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKER-EMQQLLSQPQHEREKEV 123
+ LE+ R EQ AQ+ + + LT + K R E+ + QHER+ +
Sbjct: 1587 E--LERACRVAEQAAND----LRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQG 1640
Query: 124 VLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG 183
R E R + A + + + + +RTL A R+ + +
Sbjct: 1641 ---RDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAA------------RKKLEGELE 1685
Query: 184 ERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHA 243
E + G + K+Q + + L ++V + N ++ ++GL A
Sbjct: 1686 ELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEA 1745
Query: 244 QLRGLQ------------IPHEPELMRKEISRLN----------RQLEEKINDCAEVKQE 281
++ LQ + + M E++ N RQLE ++ ++++E
Sbjct: 1746 EVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLG---QLEEE 1802
Query: 282 LAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWR 341
L ++ + +R + L Q+ + + +ER+ +A+S Q+LE ++ L ++
Sbjct: 1803 LEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLG-- 1860
Query: 342 QDSREPDAG 350
E DAG
Sbjct: 1861 ----EEDAG 1865
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo
sapiens]
Length = 1478
Score = 63.5 bits (153), Expect = 3e-10
Identities = 81/338 (23%), Positives = 141/338 (41%), Gaps = 34/338 (10%)
Query: 19 ALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGD--AAPSLVDALLEQVARFRE 76
AL Y QR +Q LA+ +A A +R +E A +A+ Q+A
Sbjct: 641 ALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEA 700
Query: 77 QLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG--- 133
L+ +EG Q+R+E+E+ + E + RE++ L SQ Q + + VL +G
Sbjct: 701 ILQSKEGECQ--QLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGP 758
Query: 134 ---ERARAASDVLCRSLAN-ETHQ--LRRTLTATAHMCQHLAKCLDERQHAQRNVGERSP 187
AR + L S A E HQ ++R + + LD++ Q +
Sbjct: 759 PTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEA 818
Query: 188 DQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNA----------SRDEY 237
EH ++++++L+E+N L + HV++L +R A R+E
Sbjct: 819 VLREH-------KTLVQQLKEQNEALNR--AHVQELLQCSEREGALQEERADEAQQREEE 869
Query: 238 VRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQ 297
+R L +L Q E + E + L QL D AE+ ++ A ++ E +
Sbjct: 870 LRALQEELS--QAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALA 927
Query: 298 MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLL 335
Q++ K+ ER ER + +Q+ +E + L
Sbjct: 928 CAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKL 965
Score = 60.8 bits (146), Expect = 2e-09
Identities = 97/432 (22%), Positives = 169/432 (39%), Gaps = 61/432 (14%)
Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVD--------ALLEQVARFREQ 77
E +L Q QL + RL+A++ L+ +L D ++ E V R +
Sbjct: 766 ELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKT 825
Query: 78 LRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERAR 137
L +Q EA R ++ L + E+E +Q+ + +RE+E+ L+ +++ A+
Sbjct: 826 LVQQLKEQNEALNRAHVQELLQ-CSEREGALQEERADEAQQREEELRALQEELSQ---AK 881
Query: 138 AASDVLCRSLANETHQLRRTLTATAHM----C----------QHLAKCLDERQHAQRNVG 183
+S+ A QL R T TA + C + LA + E Q A+
Sbjct: 882 CSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAAS 941
Query: 184 ERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHA 243
G +Q E LQE+ + K + L A+ + H
Sbjct: 942 REREGLERQVAG---LQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQ 998
Query: 244 QLRGLQIPHEPELMR---------KEISRLNRQLEEK---INDCAEVKQELAASR----- 286
+L L+ E+M +E L QLEE+ + E ++L A++
Sbjct: 999 ELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGE 1058
Query: 287 ----TARDAALERVQML--EQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSW 340
T+ A + ML +++ A ++D + + E+A ++IQE K L +V+
Sbjct: 1059 KLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNK---LCQEVTN 1115
Query: 341 RQDSREPDAGRIHAGSKTAKYLAADALELMVPGGWRPGTGSQQPEPPAEGGHP-GAAQRG 399
R+ + + + ++T KYL +EL+ R Q E A +R
Sbjct: 1116 RERNDQKMLADLDDLNRTKKYLEERLIELL-----RDKDALWQKSDALEFQQKLSAEERW 1170
Query: 400 QGDLQCPHCLQC 411
GD + HCL C
Sbjct: 1171 LGDTEANHCLDC 1182
Score = 48.1 bits (113), Expect = 1e-05
Identities = 82/371 (22%), Positives = 149/371 (40%), Gaps = 38/371 (10%)
Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ-EGG 84
E +R DQL R+ +LR R+ L+ + L V++ EQL+ + E G
Sbjct: 230 EGFDEMRLELDQLEVREK---QLRERMQQLDREN-----QELRAAVSQQGEQLQTERERG 281
Query: 85 AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGER----ARAAS 140
A+ + L L+ K+ E+ Q E + + L AE E A
Sbjct: 282 RTAAEDNVRLTCLVAELQ-KQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRL 340
Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQ 200
+ + + LA E R +L QHLA AQ+ S + +
Sbjct: 341 ESMLQPLAQELEATRDSLDKKN---QHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAA 397
Query: 201 SVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKE 260
+++L E+ + L+++ T VE++N ++ +A ++ V+ EL KE
Sbjct: 398 QEMQELGEKLQALERERTKVEEVN---RQQSAQLEQLVK---------------ELQLKE 439
Query: 261 ISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERA 320
+R + LE + + A +++EL+ D R+Q L +++++ R ++++
Sbjct: 440 DARAS--LERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQ 497
Query: 321 QSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALELMVPGGWRPG-T 379
Q + LE++V SL Q+ + + + + + K L D L G
Sbjct: 498 QEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLA 557
Query: 380 GSQQPEPPAEG 390
G PE P G
Sbjct: 558 GPPGPELPVAG 568
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 62.4 bits (150), Expect = 8e-10
Identities = 78/317 (24%), Positives = 144/317 (45%), Gaps = 51/317 (16%)
Query: 33 RLQDQLAARDALIAR---LRARLAALEGDAAPSLVDALLEQVARFREQLRR-QEGGAAEA 88
+LQ+QL A L A LRARL A + + L + + AR E+ R Q A +
Sbjct: 884 QLQEQLQAETELCAEAEELRARLTAKKQE----LEEICHDLEARVEEEEERCQHLQAEKK 939
Query: 89 QMRQEIERLTERLEEKEREMQQL-LSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSL 147
+M+Q I+ L E+LEE+E Q+L L + E + + + + + E + + A + + L
Sbjct: 940 KMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEK--KLL 997
Query: 148 ANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQ 207
+ + LT + LAK ++ +++I L+
Sbjct: 998 EDRIAEFTTNLTEEEEKSKSLAKLKNKH------------------------EAMITDLE 1033
Query: 208 EENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQ 267
E R +++ +E K + + + + L AQ+ L++ +L +KE
Sbjct: 1034 ERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKM----QLAKKE------- 1082
Query: 268 LEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQEL 327
EE A V++E A ++ AL++++ LE QI ++D SERA R +A+ + ++L
Sbjct: 1083 -EELQAALARVEEEAA----QKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDL 1137
Query: 328 EEKVASLLHQVSWRQDS 344
E++ +L ++ DS
Sbjct: 1138 GEELEALKTELEDTLDS 1154
Score = 55.8 bits (133), Expect = 7e-08
Identities = 81/383 (21%), Positives = 167/383 (43%), Gaps = 41/383 (10%)
Query: 2 SRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAP 61
S+D E ++ AL E +L L+D+L A + RL L A++
Sbjct: 1512 SKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFER 1571
Query: 62 SLVDALLEQVARFREQLRRQEGGAAEAQMRQEIERLT------ERLEEKEREMQQLLSQP 115
L EQ ++QL RQ EA++ E ++ + ++LE ++++ +
Sbjct: 1572 DL-QGRDEQSEEKKKQLVRQV-REMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSA 1629
Query: 116 QHEREKEVVLLRR-------SMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHL 168
R++ + LR+ M E + RA+ + + +L+ + + L
Sbjct: 1630 NKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEEL 1689
Query: 169 AKCLDERQHAQRNVGERSPDQSEHTDGHTS--------VQSVIEKLQEENRLLKQKVTHV 220
A ++ AQ+ E + D+ ++ G + +++ I +L+EE L+++ +
Sbjct: 1690 AAAERAKRQAQQERDELA-DEIANSSGKGALALEEKRRLEARIAQLEEE---LEEEQGNT 1745
Query: 221 EDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDC-AEVK 279
E +N + ++ N D+ L+ + Q + E R+++ R N++L+ K+ + VK
Sbjct: 1746 ELINDRLKKANLQIDQINTDLNLERSHAQ---KNENARQQLERQNKELKVKLQEMEGTVK 1802
Query: 280 QELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339
+ AS TA +A ++ LE+Q+ +E +R+ A +++ E+K+ +L QV
Sbjct: 1803 SKYKASITALEA---KIAQLEEQL-------DNETKERQAACKQVRRTEKKLKDVLLQVD 1852
Query: 340 WRQDSREPDAGRIHAGSKTAKYL 362
+ + E + S K L
Sbjct: 1853 DERRNAEQYKDQADKASTRLKQL 1875
Score = 50.4 bits (119), Expect = 3e-06
Identities = 66/293 (22%), Positives = 115/293 (39%), Gaps = 45/293 (15%)
Query: 68 LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124
L QV+R E++ +E + + +Q RL E E QL++ Q Q + + E
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAE--NRLTEMETLQSQLMAEKLQLQEQLQAETE 894
Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184
L AE E RA + L H L + CQHL E++ Q+N+ E
Sbjct: 895 LC----AEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQA---EKKKMQQNIQE 947
Query: 185 RSPDQSEHTDGHTSVQSVIEKLQEENRL--LKQKVTHVEDLNAKWQRYNASRDEYVRGLH 242
E +Q +EK+ E +L L+++ +ED N K
Sbjct: 948 LEEQLEEEESARQKLQ--LEKVTTEAKLKKLEEEQIILEDQNCK---------------- 989
Query: 243 AQLRGLQIPHEPELMRKEISRLNRQL---EEKINDCAEVKQELAASRTARDAALERVQML 299
+ E +L+ I+ L EEK A++K + A T + L R +
Sbjct: 990 -------LAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQ 1042
Query: 300 EQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRI 352
Q++ + + D +I EL+ ++A L Q++ +++ + R+
Sbjct: 1043 RQELEKTRRKLEGDSTD---LSDQIAELQAQIAELKMQLAKKEEELQAALARV 1092
Score = 49.7 bits (117), Expect = 5e-06
Identities = 51/273 (18%), Positives = 118/273 (43%), Gaps = 30/273 (10%)
Query: 101 LEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTA 160
LE+K+++ QLL++ E + + E +RA A + R T
Sbjct: 1439 LEKKQKKFDQLLAE-------EKTISAKYAEERDRAEA--------------EAREKETK 1477
Query: 161 TAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKV--- 217
+ + L + ++++ +R + + + V + +L++ R L+Q+V
Sbjct: 1478 ALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEM 1537
Query: 218 -THVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCA 276
T +E+L + Q A+ D +R L L+ ++ E +L ++ + + ++ +
Sbjct: 1538 KTQLEELEDELQ---ATEDAKLR-LEVNLQAMKAQFERDLQGRD-EQSEEKKKQLVRQVR 1592
Query: 277 EVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
E++ EL R R A+ + LE + + S +R+ A ++++L+ ++ +
Sbjct: 1593 EMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMR 1652
Query: 337 QVSWRQDSREPDAGRIHAGSKTAKYLAADALEL 369
++ + SRE + K K + A+ ++L
Sbjct: 1653 ELDDTRASREEILAQAKENEKKLKSMEAEMIQL 1685
Score = 45.1 bits (105), Expect = 1e-04
Identities = 89/410 (21%), Positives = 162/410 (39%), Gaps = 84/410 (20%)
Query: 31 LRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG------ 84
L R++++ A ++ + ++R LE + D E+ +R + + ++++ G
Sbjct: 1089 LARVEEEAAQKNMALKKIRE----LESQISELQEDLESERASRNKAEKQKRDLGEELEAL 1144
Query: 85 -----------AAEAQMR----QEIERLTERLEEKER-------EMQQLLSQPQHEREKE 122
AA+ ++R QE+ L + LEE+ + EM+Q SQ E ++
Sbjct: 1145 KTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQ 1204
Query: 123 VVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNV 182
+ +R A E+A+ + LANE L + + H + + L E Q + N
Sbjct: 1205 LEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQ-VKFNE 1263
Query: 183 GER--------------------------SPDQSEHTDGHTSVQSVI----EKLQEENR- 211
GER S+ T ++++S + E LQEENR
Sbjct: 1264 GERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQ 1323
Query: 212 --LLKQKVTHVEDLNAKWQRYNASRDE-------YVRGLHAQLRGLQIPHEPELMRKEIS 262
L K+ VED ++ +E + LHAQ+ ++ E + E +
Sbjct: 1324 KLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETA 1383
Query: 263 -RLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQ 321
+ R+L++ + ++ +E A+ + R+Q +L D + E+ Q
Sbjct: 1384 EEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQ 1443
Query: 322 SRIQEL--EEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLA-ADALE 368
+ +L EEK S + + E D A K K L+ A ALE
Sbjct: 1444 KKFDQLLAEEKTISAKY-------AEERDRAEAEAREKETKALSLARALE 1486
Score = 42.4 bits (98), Expect = 8e-04
Identities = 64/317 (20%), Positives = 132/317 (41%), Gaps = 35/317 (11%)
Query: 36 DQLAARDALIA------RLRARLAALEGDA-APSLVDALLE------QVARFREQLR--- 79
DQL A + I+ R RA A E + A SL AL E ++ R +Q R
Sbjct: 1447 DQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEM 1506
Query: 80 ------RQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVL---LRRSM 130
+ + G + ++ + L +++EE + ++++L + Q + ++ L L+
Sbjct: 1507 EDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMK 1566
Query: 131 AEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQS 190
A+ ER D ++ + ++ L + A+ DER+ V R +
Sbjct: 1567 AQFERDLQGRD-------EQSEEKKKQLVRQVREME--AELEDERKQRSMAVAARKKLEM 1617
Query: 191 EHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQ- 249
+ D + S + E + L++ ++D + ASR+E + + L+
Sbjct: 1618 DLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKS 1677
Query: 250 IPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDD 309
+ E +++E++ R + + E+ E+A S ALE + LE +I +++
Sbjct: 1678 MEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEE 1737
Query: 310 FMSERADRERAQSRIQE 326
E+ + E R+++
Sbjct: 1738 LEEEQGNTELINDRLKK 1754
Score = 38.1 bits (87), Expect = 0.015
Identities = 32/121 (26%), Positives = 60/121 (49%), Gaps = 6/121 (4%)
Query: 216 KVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKIND- 274
KV + ++ + + A +E V+ QL E E ++ ++ QL+E++
Sbjct: 833 KVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAE 892
Query: 275 ---CAEVKQELAASRTARDAALERV-QMLEQQILAYKDDFMSERADRERAQSRIQELEEK 330
CAE +EL A TA+ LE + LE ++ ++ +A++++ Q IQELEE+
Sbjct: 893 TELCAEA-EELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQ 951
Query: 331 V 331
+
Sbjct: 952 L 952
Score = 33.5 bits (75), Expect = 0.38
Identities = 68/306 (22%), Positives = 120/306 (39%), Gaps = 49/306 (16%)
Query: 31 LRRLQDQLAARDALIARLRA---RLAALEGDAAPSLVDALLEQVARFREQLRRQE----- 82
+R L D A+R+ ++A+ + +L ++E + + + A+ + Q R E
Sbjct: 1651 MRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEI 1710
Query: 83 -----GGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVL----------LR 127
GA + ++ +E +LEE E E +Q ++ ++R K+ L L
Sbjct: 1711 ANSSGKGALALEEKRRLEARIAQLEE-ELEEEQGNTELINDRLKKANLQIDQINTDLNLE 1769
Query: 128 RSMAE-GERARAASDVLCRSLANETHQLRRT--------LTATAHMCQHLAKCLD----E 174
RS A+ E AR + + L + ++ T +TA L + LD E
Sbjct: 1770 RSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKE 1829
Query: 175 RQHAQRNVGERSPDQSEHT----DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRY 230
RQ A + V + D + + ++ + + LKQ +E+ + QR
Sbjct: 1830 RQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRA 1889
Query: 231 NASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARD 290
NASR + R L + M +E+S L +L D V A + A D
Sbjct: 1890 NASRRKLQRELE------DATETADAMNREVSSLKNKLRR--GDLPFVVPRRMARKGAGD 1941
Query: 291 AALERV 296
+ E V
Sbjct: 1942 GSDEEV 1947
>gi|223671870 inhibitor of kappa light polypeptide gene enhancer in
B-cells, kinase gamma isoform b [Homo sapiens]
Length = 487
Score = 62.4 bits (150), Expect = 8e-10
Identities = 93/426 (21%), Positives = 164/426 (38%), Gaps = 61/426 (14%)
Query: 35 QDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAE------- 87
QD L L L + +G AP + LE+ R+ +R+ E
Sbjct: 92 QDVLGEESPLGKPAMLHLPSEQG--APETLQRCLEENQELRDAIRQSNQILRERCEELLH 149
Query: 88 --AQMRQEIERLTERLEEKEREMQQL------LSQPQHEREKEVVLLRRSMAEGERARAA 139
A R+E E L + +E + +++L L + + + +EV L+R + +A+
Sbjct: 150 FQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKAS 209
Query: 140 SDVLCRSLANETHQLRRTLTATAHMCQHL-AKCLDERQHAQRNVGERSPDQSEHTDGHTS 198
SL E + + L A CQ L + + A++ ER Q +H+
Sbjct: 210 VKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQ 269
Query: 199 V----QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGL---HAQLRGLQIP 251
+ QSV L+ E + ++ + L + + D +++ + RG+Q+
Sbjct: 270 LRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL- 328
Query: 252 HEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFM 311
+++ + +Q EE + EV +L +E V +L+ Q YK DF
Sbjct: 329 -------EDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQ 381
Query: 312 SERADRERAQSRIQELEEKVASLLHQ-----VSWRQDSREPDAGRIHAGSKTAKYLAADA 366
+ER RE+ + + L+E++ L + S ++ +R D + H A A A
Sbjct: 382 AERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPA 441
Query: 367 L---ELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPHCLQCFSDEQGEELLRH 423
L +P SQ+ PP E D CP C + + L H
Sbjct: 442 YLSSPLALP--------SQRRSPPEE----------PPDFCCPKCQ--YQAPDMDTLQIH 481
Query: 424 VAECCQ 429
V EC +
Sbjct: 482 VMECIE 487
>gi|4504631 inhibitor of kappa light polypeptide gene enhancer in
B-cells, kinase gamma isoform a [Homo sapiens]
Length = 419
Score = 62.4 bits (150), Expect = 8e-10
Identities = 93/426 (21%), Positives = 164/426 (38%), Gaps = 61/426 (14%)
Query: 35 QDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAE------- 87
QD L L L + +G AP + LE+ R+ +R+ E
Sbjct: 24 QDVLGEESPLGKPAMLHLPSEQG--APETLQRCLEENQELRDAIRQSNQILRERCEELLH 81
Query: 88 --AQMRQEIERLTERLEEKEREMQQL------LSQPQHEREKEVVLLRRSMAEGERARAA 139
A R+E E L + +E + +++L L + + + +EV L+R + +A+
Sbjct: 82 FQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKAS 141
Query: 140 SDVLCRSLANETHQLRRTLTATAHMCQHL-AKCLDERQHAQRNVGERSPDQSEHTDGHTS 198
SL E + + L A CQ L + + A++ ER Q +H+
Sbjct: 142 VKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQ 201
Query: 199 V----QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGL---HAQLRGLQIP 251
+ QSV L+ E + ++ + L + + D +++ + RG+Q+
Sbjct: 202 LRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL- 260
Query: 252 HEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFM 311
+++ + +Q EE + EV +L +E V +L+ Q YK DF
Sbjct: 261 -------EDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQ 313
Query: 312 SERADRERAQSRIQELEEKVASLLHQ-----VSWRQDSREPDAGRIHAGSKTAKYLAADA 366
+ER RE+ + + L+E++ L + S ++ +R D + H A A A
Sbjct: 314 AERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPA 373
Query: 367 L---ELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPHCLQCFSDEQGEELLRH 423
L +P SQ+ PP E D CP C + + L H
Sbjct: 374 YLSSPLALP--------SQRRSPPEE----------PPDFCCPKCQ--YQAPDMDTLQIH 413
Query: 424 VAECCQ 429
V EC +
Sbjct: 414 VMECIE 419
>gi|153792133 inhibitor of kappa light polypeptide gene enhancer in
B-cells, kinase gamma isoform a [Homo sapiens]
Length = 419
Score = 62.4 bits (150), Expect = 8e-10
Identities = 93/426 (21%), Positives = 164/426 (38%), Gaps = 61/426 (14%)
Query: 35 QDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAE------- 87
QD L L L + +G AP + LE+ R+ +R+ E
Sbjct: 24 QDVLGEESPLGKPAMLHLPSEQG--APETLQRCLEENQELRDAIRQSNQILRERCEELLH 81
Query: 88 --AQMRQEIERLTERLEEKEREMQQL------LSQPQHEREKEVVLLRRSMAEGERARAA 139
A R+E E L + +E + +++L L + + + +EV L+R + +A+
Sbjct: 82 FQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKAS 141
Query: 140 SDVLCRSLANETHQLRRTLTATAHMCQHL-AKCLDERQHAQRNVGERSPDQSEHTDGHTS 198
SL E + + L A CQ L + + A++ ER Q +H+
Sbjct: 142 VKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQ 201
Query: 199 V----QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGL---HAQLRGLQIP 251
+ QSV L+ E + ++ + L + + D +++ + RG+Q+
Sbjct: 202 LRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL- 260
Query: 252 HEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFM 311
+++ + +Q EE + EV +L +E V +L+ Q YK DF
Sbjct: 261 -------EDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQ 313
Query: 312 SERADRERAQSRIQELEEKVASLLHQ-----VSWRQDSREPDAGRIHAGSKTAKYLAADA 366
+ER RE+ + + L+E++ L + S ++ +R D + H A A A
Sbjct: 314 AERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPA 373
Query: 367 L---ELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPHCLQCFSDEQGEELLRH 423
L +P SQ+ PP E D CP C + + L H
Sbjct: 374 YLSSPLALP--------SQRRSPPEE----------PPDFCCPKCQ--YQAPDMDTLQIH 413
Query: 424 VAECCQ 429
V EC +
Sbjct: 414 VMECIE 419
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 61.6 bits (148), Expect = 1e-09
Identities = 90/428 (21%), Positives = 174/428 (40%), Gaps = 84/428 (19%)
Query: 8 GGWEEAPRAAAALCTLYHEAGQRLRRLQDQLA-ARDALIARLRARLAALEGDAAP----- 61
G +EE + ++L T + L + +++L A A ARL A++A+L +
Sbjct: 455 GHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATI 514
Query: 62 --------SLVDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS 113
L E+ A+ + L++QE A +R ++E+L+ L++KE++++++
Sbjct: 515 QQQDQELAGLKQQAKEKQAQLAQTLQQQE--QASQGLRHQVEQLSSSLKQKEQQLKEVAE 572
Query: 114 QPQHEREKEVVLLRRSMAEGERARAASDVLCRSL--------------------ANETH- 152
+ + R+ L + E E + D + L ANE
Sbjct: 573 KQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARD 632
Query: 153 -------QLRRTLTATAHMCQHLAKCLD----ERQHAQRNVGERS----PDQSEHTDGHT 197
Q +R + + L C++ E+ AQ V E +Q + T+
Sbjct: 633 SAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKER 692
Query: 198 SVQSVIEKLQEENRLLKQ--KVTHVEDLNAKWQRYNASRDEY--VRGLHAQLRGLQIPHE 253
Q ++LQE+ + LK+ KVT K + +A ++ + L A+ R L H+
Sbjct: 693 VAQEK-DQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHK 751
Query: 254 PELMRKEISRLNRQ-LEEKINDCAEVKQ--------ELAASRTARDAALERVQMLEQQIL 304
E E R R+ LE ++ E Q ELA + A+ A + L +++
Sbjct: 752 RERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVA 811
Query: 305 AYKDDF------------------MSERADRERAQSRIQELEEKVASLLHQVSWRQDSRE 346
A+++ + M+ + + E+A+ +QE +EKVA + + ++
Sbjct: 812 AWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQ 871
Query: 347 PDAGRIHA 354
+ +HA
Sbjct: 872 NELAELHA 879
Score = 57.8 bits (138), Expect = 2e-08
Identities = 84/347 (24%), Positives = 136/347 (39%), Gaps = 46/347 (13%)
Query: 31 LRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQ----LRRQEGG-- 84
L LQ+++AA +ARL L G+ + L+++ AR ++ L Q+G
Sbjct: 902 LSTLQEKMAATSKEVARLET-LVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQF 960
Query: 85 ----AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHER---EKEVVLLRRS-------M 130
AA M +E E++ LE + + Q Q ER E+EV L + +
Sbjct: 961 CSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADL 1020
Query: 131 AEGERARAASDVLCRSLANETH--------QLRRTLTATAHMCQHLAKC----------L 172
A + ARA ++ ++ NE L LT Q LAK L
Sbjct: 1021 ALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKEL 1080
Query: 173 DERQHAQRNVGER-SPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYN 231
+E + + + E+ + + EH G + + + L+ V L + Q+
Sbjct: 1081 EELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQ 1140
Query: 232 ASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDA 291
D R L A+ R + + L L QLEEK + + LA+++ A
Sbjct: 1141 EQADSLERSLEAE-RASRAERDSAL-----ETLQGQLEEKAQELGHSQSALASAQRELAA 1194
Query: 292 ALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV 338
+VQ + +K R + ER S I LEE+V+ L QV
Sbjct: 1195 FRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQV 1241
Score = 55.1 bits (131), Expect = 1e-07
Identities = 70/295 (23%), Positives = 126/295 (42%), Gaps = 34/295 (11%)
Query: 52 LAALEGDAAPSL--VDALLEQVARFREQLRRQE-----GGAAEAQMRQEIERLTERLEEK 104
LA L G A + ++ L + V + +EQL ++E G A+++ E +LE
Sbjct: 1066 LAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEAL 1125
Query: 105 EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAAS-----DVLCRSLANETHQLRRTLT 159
E+ +L Q Q ++E + L RS+ E ERA A + L L + +L + +
Sbjct: 1126 RAEVSKLEQQCQKQQE-QADSLERSL-EAERASRAERDSALETLQGQLEEKAQELGHSQS 1183
Query: 160 ATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTH 219
A A + LA + Q + E + S+I L+EE +L ++V
Sbjct: 1184 ALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLE 1243
Query: 220 VEDLNAKWQRYNASRDEYVRGLHAQLRGLQIP---------HEPELMRKEISRLNRQLEE 270
E + + +R + E + L +LR LQ +R+E+ L + E+
Sbjct: 1244 KEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEK 1303
Query: 271 KINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQ 325
+ ++QEL + ER + L Q++ A+++ F +E+A S +Q
Sbjct: 1304 QRVASENLRQELTSQ-------AERAEELGQELKAWQEKFF----QKEQALSTLQ 1347
Score = 47.8 bits (112), Expect = 2e-05
Identities = 83/362 (22%), Positives = 142/362 (39%), Gaps = 34/362 (9%)
Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRA-------RLAALEGDAAPSL 63
E + AA L + R+ L+ + ++A + R +L++L D S+
Sbjct: 416 ETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSI 475
Query: 64 VDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEV 123
+ L Q EQ + G AQ+ LT +++ Q+L Q +EK+
Sbjct: 476 SN--LSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQA 533
Query: 124 VL---LRRSMAEGERARAASDVLCRSLANETHQL-----RRTLTATAHMCQHLAKCLDER 175
L L++ + R + L SL + QL ++ T H Q LA +ER
Sbjct: 534 QLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDH-AQQLATAAEER 592
Query: 176 QHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRD 235
+ + R ER + + +E LQ++ ++ + + + QR A
Sbjct: 593 EASLR---ERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELS 649
Query: 236 EYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALE 294
V L A + Q HE + E+ R ++K + V QE +D E
Sbjct: 650 RKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQE-------KDQLQE 702
Query: 295 RVQMLEQQILAYKDDFMSER---ADRERAQSR-IQELEEKVASLLHQ-VSWRQDSREPDA 349
++Q L++ + K E+ AD Q R I EL+ + SL+ Q R++ E A
Sbjct: 703 QLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERA 762
Query: 350 GR 351
GR
Sbjct: 763 GR 764
Score = 47.8 bits (112), Expect = 2e-05
Identities = 73/354 (20%), Positives = 144/354 (40%), Gaps = 50/354 (14%)
Query: 30 RLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFRE------QLRRQEG 83
RL++L + A ++ R A A + A S + L+++VA +RE Q Q G
Sbjct: 770 RLQQLGEAHQAETEVLRRELAEAMAAQ-HTAESECEQLVKEVAAWRERYEDSQQEEAQYG 828
Query: 84 GAAEAQM----------RQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG 133
+ Q+ RQE++ E++ E + +S+ Q+E + L R++ +
Sbjct: 829 AMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQV 888
Query: 134 ERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNV-------GERS 186
+ + L L+ ++ T A + + K ++++ A R + G+R
Sbjct: 889 QEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQ 948
Query: 187 PDQSEHTDGH--TSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQ 244
P+ E G S Q+ ++ ++ E E + + +R A+ E +G +
Sbjct: 949 PEWLEEQQGRQFCSTQAALQAMERE----------AEQMGNELERLRAALME-SQGQQQE 997
Query: 245 LRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQIL 304
RG Q E E+ R R Q + + A + E+ + +E + Q+ L
Sbjct: 998 ERGQQ---EREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATL--QEAL 1052
Query: 305 AY-------KDDFMSERADRERAQ-SRIQELEEKVASLLHQVSWRQDSREPDAG 350
A+ KD +++ E AQ ++EL + V L Q++ ++ +G
Sbjct: 1053 AHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSG 1106
Score = 47.4 bits (111), Expect = 3e-05
Identities = 87/371 (23%), Positives = 146/371 (39%), Gaps = 45/371 (12%)
Query: 18 AALCTLYHEA---GQRLRRLQDQLAARDALIARLRAR----LAALEGDAAPSLVDALLEQ 70
AAL + EA G L RL+ L R + +A L + + D LE+
Sbjct: 965 AALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEK 1024
Query: 71 VARFREQLRRQEG-GAAEAQMRQEIERLTERLEEKEREMQQLLS---------QPQHERE 120
AR ++R Q + E L L EKE + Q+L + E
Sbjct: 1025 AARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELR 1084
Query: 121 KEVVLLRRSMAEGERARAASDVLCRSLANETHQ-------LRRTLTATAHMCQHLAKCLD 173
+ V L+ +A+ E+ A+ A T LR ++ CQ K +
Sbjct: 1085 QTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQ---KQQE 1141
Query: 174 ERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEE----NRLLKQKVTHVEDLNAKWQR 229
+ +R++ ++E ++Q +E+ +E L + K Q
Sbjct: 1142 QADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQD 1201
Query: 230 YNASRDEYVRGLHAQL-RGLQIPHEPELM----RKEISRLNRQLEEKINDCAEVKQELAA 284
++ + DE+ AQ+ RG Q + +E+S LNRQ+ EK + E+K+ + A
Sbjct: 1202 HSKAEDEW----KAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMA 1257
Query: 285 SRTARDAALERVQMLEQQILAYKDDFMSERAD--RERAQSRIQELE-EKVAS-LLHQVSW 340
ER+++L+ + A +ER+ RE QS +E E ++VAS L Q
Sbjct: 1258 ESEKSQKLEERLRLLQAE-TASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELT 1316
Query: 341 RQDSREPDAGR 351
Q R + G+
Sbjct: 1317 SQAERAEELGQ 1327
Score = 38.1 bits (87), Expect = 0.015
Identities = 77/353 (21%), Positives = 139/353 (39%), Gaps = 43/353 (12%)
Query: 25 HEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLE---QVARFREQLRRQ 81
H+A + +R L+ Q A + L G A + D L Q+ R ++QL +
Sbjct: 173 HQAKREIRFLELQKVASSSSGNNF------LSGSPASPMGDILQTPQFQMRRLKKQLADE 226
Query: 82 EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASD 141
E ++ E+ + L EK+ ++ + +R + LL A A
Sbjct: 227 RSNRDELEL--ELAENRKLLTEKDAQIAMM-----QQRIDRLALLNEKQA----ASPLEP 275
Query: 142 VLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQS----EHTDGHT 197
L ++ L L T CQ L + + E + D S E
Sbjct: 276 KELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQ 335
Query: 198 SVQSVIEKLQEEN-----RLLKQKVTHVEDLNAKWQRYNA--SRDEYVRGLHAQLRG--L 248
+Q + +L EE+ L+++ ++L+A Q ++E ++G +QL
Sbjct: 336 QLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLS 395
Query: 249 QIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALE-RVQMLEQQILAYK 307
Q+ P + E+ QLE +KQE AA+ A + L+ RV+MLE + +
Sbjct: 396 QLQDNPPQEKGEVLGDVLQLET-------LKQE-AATLAANNTQLQARVEMLETERGQQE 447
Query: 308 DDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360
++ER E + ++ L + S + +S ++ E A + H TA+
Sbjct: 448 AKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELE-QASQAHGARLTAQ 499
Score = 28.9 bits (63), Expect = 9.4
Identities = 40/186 (21%), Positives = 72/186 (38%), Gaps = 29/186 (15%)
Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDA--LLEQVARFREQLRRQEG 83
E +++ L +LA D + +L A++ S +A L Q+ + QL ++E
Sbjct: 1546 EQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQ 1605
Query: 84 GA---------------AEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRR 128
A A+ Q QE++ LE+ ++E ++L ++ + L
Sbjct: 1606 AAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAER--------LGH 1657
Query: 129 SMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPD 188
+ + ++ CR L T Q+R AH Q L + L + Q A + R P
Sbjct: 1658 ELQQAGLKTKEAEQTCRHL---TAQVRSLEAQVAHADQQL-RDLGKFQVATDALKSREPQ 1713
Query: 189 QSEHTD 194
D
Sbjct: 1714 AKPQLD 1719
>gi|126723390 ankyrin repeat domain 24 [Homo sapiens]
Length = 1146
Score = 61.6 bits (148), Expect = 1e-09
Identities = 83/358 (23%), Positives = 147/358 (41%), Gaps = 56/358 (15%)
Query: 14 PRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVAR 73
P AA A L E R+R L++ L R R R AA E +AA +A + R
Sbjct: 712 PGAAEASEKLQVELETRIRGLEEAL--------RQREREAAAELEAALGKCEAAEAEAGR 763
Query: 74 FREQLRRQEGGAAE-------AQMRQEIERLTERLEEKEREMQQL------LSQPQHER- 119
RE++R EG A Q+R +E+ E L +++ +++L L + + R
Sbjct: 764 LRERVREAEGSGASGGGGGDTTQLRAALEQAREDLRDRDSRLRELEAASACLDEARASRL 823
Query: 120 --EKEVVLLRRSMAEGERARAAS----DVLCRSLANETHQLRRTLTATAHMCQHLAKCLD 173
E+E LR +A+ E AR +VL LA + TA A + +
Sbjct: 824 LAEEEARGLRAELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGR------- 876
Query: 174 ERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQE------ENRLLKQKVTHVEDLNAKW 227
R A+ V E E G ++ E L++ E+R L+++ + A
Sbjct: 877 ARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASL 936
Query: 228 QRYNASRDEYVRGLHAQLRGLQI------PHEPEL---------MRKEISRLNRQLEEKI 272
++ + + L A+L ++ HE + + ++ L R+ E+
Sbjct: 937 EQEVVATGKEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTS 996
Query: 273 NDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEK 330
+ +V++E ++ R AA ++ EQQ+ + + R + RAQ + + +EK
Sbjct: 997 AEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEK 1054
Score = 36.2 bits (82), Expect = 0.059
Identities = 81/368 (22%), Positives = 135/368 (36%), Gaps = 79/368 (21%)
Query: 67 LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHE-----REK 121
LL+++ + R++ + EA +ER + E+QQLL + Q E RE
Sbjct: 336 LLQKIRGLEQHKERRQQESPEASSLHILERQVQ-------ELQQLLVERQEEKESLGREV 388
Query: 122 EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRN 181
E + R S+ E ER + DV +L +E +L A + + L
Sbjct: 389 ESLQSRLSLLENERENTSYDV--TTLQDEEGELPDLPGAEVLLSRQL------------- 433
Query: 182 VGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQR------------ 229
SP EH S+Q + L +N+ L +KV +E+ +
Sbjct: 434 ----SPSAQEHL---ASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIPL 486
Query: 230 --YNASRDEY--VRGLHAQ-LRGLQIPHEPELMRKEIS--------------------RL 264
Y++ R E+ +R HA+ L+ L+ E+ R+E + L
Sbjct: 487 ALYDSLRAEFDQLRRQHAEALQALRQQETREVPREEGAACGESEVAGATATKNGPTHMEL 546
Query: 265 NRQL--EEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQS 322
N + E K+N + +E A T +E + A A+
Sbjct: 547 NGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGAEV 606
Query: 323 RIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALELMVPGGWRPGTGSQ 382
R E E+ A++ + + Q + G G + K A +A E+ G G+
Sbjct: 607 REMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEA-EMQA-----YGVGAG 660
Query: 383 QPEPPAEG 390
Q EPP G
Sbjct: 661 QAEPPVTG 668
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 61.2 bits (147), Expect = 2e-09
Identities = 66/322 (20%), Positives = 148/322 (45%), Gaps = 33/322 (10%)
Query: 30 RLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ-----EGG 84
++ R +++L A+D + +++ + +EG+ LE++ R +QL + E
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGE---------LEEMERKHQQLLEEKNILAEQL 896
Query: 85 AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLC 144
AE ++ E E + RL K++E++++L + E+E + E ++ +A L
Sbjct: 897 QAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLE 956
Query: 145 RSL-----ANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV 199
L A + QL + +TA A + + + L + + E+ + + + +
Sbjct: 957 EQLDEEEGARQKLQLEK-VTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQL 1015
Query: 200 QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259
EK + ++ ++ + DL + ++ +R E + ++ E ++
Sbjct: 1016 AEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKR------KLDGETTDLQD 1069
Query: 260 EISRLNRQLEEKINDCAEVKQELAASRTARDA-------ALERVQMLEQQILAYKDDFMS 312
+I+ L Q++E A+ ++EL + D AL+ V+ L+ QI ++DF S
Sbjct: 1070 QIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFES 1129
Query: 313 ERADRERAQSRIQELEEKVASL 334
E+A R +A+ + ++L E++ +L
Sbjct: 1130 EKASRNKAEKQKRDLSEELEAL 1151
Score = 58.5 bits (140), Expect = 1e-08
Identities = 83/405 (20%), Positives = 172/405 (42%), Gaps = 49/405 (12%)
Query: 2 SRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAP 61
S+D E ++ AL E +L L+D+L A + RL + A++
Sbjct: 1519 SKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER 1578
Query: 62 SLVDA----------LLEQVARFREQL---RRQEGGAAEAQMRQEIER--LTERLEEKER 106
L L++QV +L R+Q A ++ + EI+ L ++E +
Sbjct: 1579 DLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANK 1638
Query: 107 EMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQ 166
+++ Q + K ++ E E ARA+ D + +L+ + +
Sbjct: 1639 ARDEVIKQLR----KLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQE 1694
Query: 167 HLAKCLDERQHAQRNVGERSPDQSEHTDGHTS-------VQSVIEKLQEENRLLKQKVTH 219
LA R+HA++ E + + + G ++ +++ I +L+EE L+++ ++
Sbjct: 1695 ELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEE---LEEEQSN 1751
Query: 220 VEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDC-AEV 278
+E LN ++++ D L A+ Q + + R+++ R N++L+ K+ + V
Sbjct: 1752 MELLNDRFRKTTLQVDTLNAELAAERSAAQ---KSDNARQQLERQNKELKAKLQELEGAV 1808
Query: 279 KQELAASRTARDAALERV-QMLEQQI--------------LAYKDDFMSERADRERAQSR 323
K + A+ +A +A + ++ + LEQ+ K+ FM +R A +
Sbjct: 1809 KSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHA-DQ 1867
Query: 324 IQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368
+E EK + + Q+ + + E +A R +A + + DA E
Sbjct: 1868 YKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATE 1912
Score = 47.0 bits (110), Expect = 3e-05
Identities = 72/371 (19%), Positives = 153/371 (41%), Gaps = 71/371 (19%)
Query: 30 RLRRLQDQLAARDAL---IARLRARLAALEGDAAPSLVDALLEQVARFREQL----RRQE 82
R+ QLA + +A++R + + D ++ L++ + R++L R+ +
Sbjct: 1007 RIAECSSQLAEEEEKAKNLAKIRNKQEVMISD-----LEERLKKEEKTRQELEKAKRKLD 1061
Query: 83 GGAAE-----AQMRQEIERLTERLEEKEREMQQLLSQPQHER-------------EKEVV 124
G + A+++ +I+ L +L +KE E+Q L++ E + ++
Sbjct: 1062 GETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIA 1121
Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184
L+ + +R ++ R L+ E L+ L T A + R ++ V E
Sbjct: 1122 ELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTT---AAQQELRTKREQEVAE 1178
Query: 185 RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQ---RYNASRDEYVRGL 241
E T H ++ I+ +++ + T +E+L+ + + R+ A+ ++ +GL
Sbjct: 1179 LKKALEEETKNH---EAQIQDMRQRH------ATALEELSEQLEQAKRFKANLEKNKQGL 1229
Query: 242 HAQLRGL--------QIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAAL 293
+ L Q+ E E RK++ ++L K+++ ++ ELA + L
Sbjct: 1230 ETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNEL 1289
Query: 294 ERVQ------------------MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLL 335
+ V LE Q+ ++ E + SRI++LEE+ SL
Sbjct: 1290 DNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQ 1349
Query: 336 HQVSWRQDSRE 346
Q +++R+
Sbjct: 1350 EQQEEEEEARK 1360
Score = 46.6 bits (109), Expect = 4e-05
Identities = 86/380 (22%), Positives = 149/380 (39%), Gaps = 54/380 (14%)
Query: 34 LQDQLAARDALIARLRARLAALEGDAAPSL----------------VDALLEQVARFREQ 77
LQDQ+A A I L+ +LA E + +L V L Q+A +E
Sbjct: 1067 LQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQED 1126
Query: 78 LRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS------QPQHEREKEVVLLRRSMA 131
++ +A+ ++ L+E LE + E++ L + + +RE+EV L++++
Sbjct: 1127 FESEKASRNKAEKQKR--DLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALE 1184
Query: 132 EGERARAASDVLCRSL-ANETHQLRRTLTATAHMCQHLAKC-----LDERQHA-QRNVGE 184
E + A R A +L L +L K D ++ A + V +
Sbjct: 1185 EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQ 1244
Query: 185 RSPDQSEHTDGH--TSVQSVIEKLQEENRL----------LKQKVTHVEDLNAKWQRYNA 232
+ +SEH VQ + K+ E +RL L+ ++ +V L + ++
Sbjct: 1245 QVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGI 1304
Query: 233 SRDEYVRGLHAQLRGLQIPHEPELMRK-EISRLNRQLEEKINDCAEVKQELAASRTARDA 291
+ L +QL+ Q + E +K +S RQLEE+ N E ++E +R
Sbjct: 1305 KFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEAR----- 1359
Query: 292 ALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGR 351
+ LE+Q+LA + + + I+ LEE LL E A
Sbjct: 1360 -----KNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALA 1414
Query: 352 IHAGSKTAKYLAADALELMV 371
KT L + +L V
Sbjct: 1415 YDKLEKTKNRLQQELDDLTV 1434
Score = 37.7 bits (86), Expect = 0.020
Identities = 71/349 (20%), Positives = 132/349 (37%), Gaps = 63/349 (18%)
Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85
E ++ +LQ++L L+ + DAA SL L + +E+ R++ +
Sbjct: 1277 ELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAA-SLESQLQDTQELLQEETRQKLNLS 1335
Query: 86 AEA-QMRQEIERLTERLEEKER-----EMQQLLSQPQ------------------HEREK 121
+ Q+ +E L E+ EE+E E Q L Q Q E +K
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395
Query: 122 EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQH---- 177
+++ ++++ +A + N Q LT + +A L+++Q
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455
Query: 178 --------AQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQR 229
+ R ER ++E + T S+ L+E ++ + L A +
Sbjct: 1456 LLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMED 1515
Query: 230 YNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR 289
+S+D+ + +H + K L +Q+EE E++ EL A+ A+
Sbjct: 1516 LMSSKDDVGKNVHE-------------LEKSKRALEQQVEEMRTQLEELEDELQATEDAK 1562
Query: 290 DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV 338
LE + A K F + Q+R ++ EEK L+ QV
Sbjct: 1563 -------LRLEVNMQAMKAQFERD------LQTRDEQNEEKKRLLIKQV 1598
Score = 33.5 bits (75), Expect = 0.38
Identities = 34/148 (22%), Positives = 74/148 (50%), Gaps = 5/148 (3%)
Query: 197 TSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRG-LQIPHEPE 255
T + ++ EE +K+K T VE + +R + E L QL+ ++ E E
Sbjct: 848 TRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAE 907
Query: 256 LMRKEISRLNRQLEEKINDC-AEVKQELAASRTARDAALE---RVQMLEQQILAYKDDFM 311
MR ++ ++LEE ++D + V++E ++ ++ + +Q LE+Q+ +
Sbjct: 908 EMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQ 967
Query: 312 SERADRERAQSRIQELEEKVASLLHQVS 339
+ ++ A+++I+++EE++ L Q S
Sbjct: 968 KLQLEKVTAEAKIKKMEEEILLLEDQNS 995
Score = 32.0 bits (71), Expect = 1.1
Identities = 42/205 (20%), Positives = 81/205 (39%), Gaps = 42/205 (20%)
Query: 64 VDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEV 123
VD L ++A R ++ + A Q+ ++ + L +L+E E ++ E ++
Sbjct: 1766 VDTLNAELAAERSAAQKSDN--ARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKI 1823
Query: 124 VLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG 183
L + + + RAA++ L R + ++ + DER+HA
Sbjct: 1824 GQLEEQLEQEAKERAAANKLVRRTEKKLKEI-------------FMQVEDERRHA----- 1865
Query: 184 ERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHA 243
DQ + E++++ N +KQ +E+ + R NASR + R L
Sbjct: 1866 ----DQYK------------EQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELD- 1908
Query: 244 QLRGLQIPHEPELMRKEISRLNRQL 268
E + +E+S L +L
Sbjct: 1909 -----DATEANEGLSREVSTLKNRL 1928
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 60.8 bits (146), Expect = 2e-09
Identities = 76/349 (21%), Positives = 146/349 (41%), Gaps = 44/349 (12%)
Query: 24 YHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEG 83
Y + RL + ++A I L +L + A +L L ++ +E L +G
Sbjct: 571 YQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKG 630
Query: 84 GAAEAQ-----MRQEIERLTERLEEKEREMQQL--LSQPQHEREKEVVLLRRSMAEGERA 136
A +AQ +R E E L +RL E E+E QL ++ KE+ L ++ E
Sbjct: 631 QATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEV 690
Query: 137 RAASDVLCRSLAN--------------ETHQLRRTLTATAHMCQ----HLAKCLDERQHA 178
A+ L+ E +QL+ L + Q L L++ + A
Sbjct: 691 NASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQA 750
Query: 179 QRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQK-------VTHVEDLNAKWQRYN 231
+N ++ E ++ + + ++ LQ++N LLKQ+ + HV D + +
Sbjct: 751 LKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVA 810
Query: 232 ASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDA 291
A DE R L + I +++ K ++ L +Q E + A K E ++
Sbjct: 811 ARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEIL---ARSKWERDEAQVRERK 867
Query: 292 ALERVQMLEQQILAYKDDFMS--ERA-------DRERAQSRIQELEEKV 331
E + + ++++ +++F ERA D+ + ++RIQ++E ++
Sbjct: 868 LQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEI 916
Score = 48.5 bits (114), Expect = 1e-05
Identities = 76/321 (23%), Positives = 139/321 (43%), Gaps = 47/321 (14%)
Query: 35 QDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAE-AQMRQE 93
Q ++A D + + L L+G ++++ A +E LR E E +E
Sbjct: 1593 QQEMAVLDRQLGHKKEELHLLQG--------SMVQAKADLQEALRLGETEVTEKCNHIRE 1644
Query: 94 IERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQ 153
++ L E L ++ E+ +S ER+ ++ L+++ + E+ V+ R ++ +
Sbjct: 1645 VKSLLEELSFQKGELNVQIS----ERKTQLTLIKQEI---EKEEENLQVVLRQMSKHKTE 1697
Query: 154 LRRTLTATA---HMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEEN 210
L+ L H Q L + QH QR V E T V + EKL+ EN
Sbjct: 1698 LKNILDMLQLENHELQGL-----KLQHDQR-VSELEK---------TQVAVLEEKLELEN 1742
Query: 211 RLLKQKVTHVEDLNAKWQRYNASRDEY-VRGLHAQLRGLQIPHEPELMRKEISRLNRQLE 269
Q+++ + +WQ+ RD+ + + A+ R LQ E + KE L + +
Sbjct: 1743 L---QQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSC--VECLSKEKEDLQEKCD 1797
Query: 270 EKINDCAEVKQELAASRT---ARDAALERVQM----LEQQILAYKDDFMSERADRERAQS 322
A+ K+ LAA+ + LE++++ L+Q++ D +S D Q
Sbjct: 1798 IWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQ 1857
Query: 323 RIQELEEKVASLLHQVSWRQD 343
++QE E V SL +++ QD
Sbjct: 1858 QLQEKREAVNSLQEELANVQD 1878
Score = 46.6 bits (109), Expect = 4e-05
Identities = 69/340 (20%), Positives = 136/340 (40%), Gaps = 31/340 (9%)
Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQ-------DQLAARDALIARLRARLAALEGD--AAP 61
EE R A +A Q+LR LQ ++ ++ + +AA + D
Sbjct: 1478 EELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLS 1537
Query: 62 SLVDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREK 121
+ L E++ + ++ + E E Q ++ L+ K E+++L SQ ++++
Sbjct: 1538 KKKEKLTEELQKLQKDIEMAERN--EDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQE 1595
Query: 122 EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRN 181
VL R+ + E + ++ A+ LR T C H+ + +
Sbjct: 1596 MAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQ 1655
Query: 182 VGERSPDQSEHTDGHTSVQSVIEKLQEENR--LLKQKVTHVEDLNAKWQRYNASRDEYVR 239
GE + SE T ++ IEK +EEN +L+Q H +L E
Sbjct: 1656 KGELNVQISERKTQLTLIKQEIEK-EEENLQVVLRQMSKHKTELKNILDMLQLENHE--- 1711
Query: 240 GLHAQLRGLQIPHE---PELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALER- 295
L+GL++ H+ EL + +++ L +LE + + ++ Q+ + LER
Sbjct: 1712 -----LQGLKLQHDQRVSELEKTQVAVLEEKLE--LENLQQISQQQKGEIEWQKQLLERD 1764
Query: 296 ---VQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVA 332
++ + + A + ++E Q + E+K+A
Sbjct: 1765 KREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLA 1804
Score = 41.6 bits (96), Expect = 0.001
Identities = 85/380 (22%), Positives = 157/380 (41%), Gaps = 56/380 (14%)
Query: 26 EAGQRLRRLQDQLAARDALIAR---------LRARLAALEGDAAP--SLVDALLEQVARF 74
EA R R+LQ+++A + +A RA A + D + + + ++
Sbjct: 860 EAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYL 919
Query: 75 REQLRRQEG--GAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAE 132
+E L+ E G + Q+ QE + ER+ + RE+++ + +++V L + + +
Sbjct: 920 QENLKSMEEIQGLTDLQL-QEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKK 978
Query: 133 GERARAASDVLCRS-LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSE 191
++A A SD L + L QL+ + Q A+ L E + R + + D
Sbjct: 979 LKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDL-- 1036
Query: 192 HTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIP 251
T ++ IE LQ LL+QK + R + G ++Q+ ++
Sbjct: 1037 -----TRAEAEIELLQ---NLLRQK--------GEQFRLEMEKTGVGTGANSQVLEIEKL 1080
Query: 252 HEP-ELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDF 310
+E E R EI+RL L+ +D ++ + LE + L +++ +Y++D+
Sbjct: 1081 NETMERQRTEIARLQNVLDLTGSD----------NKGGFENVLEEIAELRREV-SYQNDY 1129
Query: 311 MSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALELM 370
+S AD + + + +S +VS D+G KY A+ +
Sbjct: 1130 ISSMADPFKRRGYWYFMPPPPSS---KVSSHSSQATKDSG------VGLKYSASTPVRKP 1180
Query: 371 VPGGWRPGTGSQQPEPPAEG 390
PG GSQ PPA G
Sbjct: 1181 RPGQQDGKEGSQ--PPPASG 1198
Score = 40.8 bits (94), Expect = 0.002
Identities = 62/280 (22%), Positives = 112/280 (40%), Gaps = 30/280 (10%)
Query: 77 QLRRQEGGAAEAQMRQEIERLTER----LEEKER--EMQQLLSQPQHEREKEVVLLRRSM 130
QL E + Q Q + L + LEEK +QQ+ Q + E E + LL R
Sbjct: 1706 QLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDK 1765
Query: 131 AEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQS 190
E ER A S R+L + L + C K L + + E S +
Sbjct: 1766 REIERMTAES----RALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQ 1821
Query: 191 EHTDGHTSVQSVIEKLQEE-NRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQ 249
+ + ++ + KLQ+E ++L + K++ D++A Q+ R E V L +L +Q
Sbjct: 1822 SNLE---KLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKR-EAVNSLQEELANVQ 1877
Query: 250 ------------IPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQ 297
+++ E +RL + + E N + ++E + ++
Sbjct: 1878 DHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIE 1937
Query: 298 MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQ 337
E ++ + + M +R +ER +S +LE +L Q
Sbjct: 1938 --ENKLKLVQQEMMFQRLQKER-ESEESKLETSKVTLKEQ 1974
Score = 38.9 bits (89), Expect = 0.009
Identities = 60/268 (22%), Positives = 108/268 (40%), Gaps = 30/268 (11%)
Query: 87 EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVV--------LLRRSMAEGERARA 138
+ M Q +++ E E K + L + QH+ EKE+ +L + +A ER R
Sbjct: 1946 QEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRT 2005
Query: 139 ASDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQS------ 190
+ C SL Q +R L+ Q L + E Q+ D S
Sbjct: 2006 LQEEERWCESLEKTLSQTKRQLSERE---QQLVEKSGELLALQKEADSMRADFSLLRNQF 2062
Query: 191 --EHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGL 248
E V S+ E L+ + L++ + + N+ Q+ A+ + + H + R L
Sbjct: 2063 LTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRL 2122
Query: 249 QIPHEPELMRKEISRLNRQLEEKINDCAEVKQELA-ASRTARDAALERVQMLEQQILAYK 307
E M+ E + L +Q+ + D + E++ A RT + + ++ + +
Sbjct: 2123 M--KELNQMQYEYTELKKQMANQ-KDLERRQMEISDAMRTLKSEVKDEIRTSLKNL---- 2175
Query: 308 DDFMSE-RADRERAQSRIQELEEKVASL 334
+ F+ E AD E R + LE ++ SL
Sbjct: 2176 NQFLPELPADLEAILERNENLEGELESL 2203
Score = 36.6 bits (83), Expect = 0.045
Identities = 57/242 (23%), Positives = 100/242 (41%), Gaps = 38/242 (15%)
Query: 80 RQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQH--EREKEVVLLRRSMAEGERAR 137
RQE A E +E+ERL LE+K E ++L S+ E K L +S+ E +
Sbjct: 260 RQE--AFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQ 317
Query: 138 AASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHT 197
S +S N ++L + T + C + + Q + + E + +
Sbjct: 318 KQSCEELKSDLNTKNELLKQKT-----IELTRACQKQYELEQELAFYKIDAKFEPLNYYP 372
Query: 198 SVQSVIEKLQEEN---------RLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGL 248
S + I+K +E+ R + +++ D Q DE +R H LRG
Sbjct: 373 SEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRG- 431
Query: 249 QIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308
H P L+ QLE+K +++++A++T + ++ EQQIL +
Sbjct: 432 ---HTP---------LDTQLEDK-------EKKISAAQTRLSELHDEIEKAEQQILRATE 472
Query: 309 DF 310
+F
Sbjct: 473 EF 474
>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
Length = 1001
Score = 60.8 bits (146), Expect = 2e-09
Identities = 70/309 (22%), Positives = 131/309 (42%), Gaps = 31/309 (10%)
Query: 83 GGAAEAQMRQEIE-------RLTERLEEKEREMQQLLSQPQ---HEREKEVVLLRRSMAE 132
GG A+ Q+ +E+ L E L E RE Q+L + Q ++E V + +
Sbjct: 606 GGLAKGQLEKEMSVLRLSNSNLLEELGELGRERQRLQRELQSLSQRLQREFVPKPEAQVQ 665
Query: 133 GERARAASDVLCRSLANE---THQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQ 189
++ R + +L LA E T +LR+ L + + + L CL +R+ ++ +
Sbjct: 666 LQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGERSAQSKAAES 725
Query: 190 SEH--------TDGHTSVQSVIEKLQEENRLLKQKVTHVED----LNAKWQRYNASRDEY 237
E D H Q V+ +LQEEN+ L+ ++ + L A A+ ++
Sbjct: 726 LEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCREPGTSLKAPASPQVAALEQD 785
Query: 238 VRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAAS----RTARDAAL 293
+ L +LR +Q + +EI +L + L + + AE++ AAS R + +
Sbjct: 786 LGKLEEELRAVQATMSGK--SQEIGKLKQLLYQATEEVAELRAREAASLRQHEKTRGSLV 843
Query: 294 ERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIH 353
+ Q Q++ A + + + + R + + E + L Q + ++ GR
Sbjct: 844 AQAQAWGQELKALLEKYNTACREVGRLREAVAEERRRSGDLAAQAAEQERQASEMRGRSE 903
Query: 354 AGSKTAKYL 362
KTA+ L
Sbjct: 904 QFEKTAELL 912
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 60.5 bits (145), Expect = 3e-09
Identities = 84/343 (24%), Positives = 141/343 (41%), Gaps = 50/343 (14%)
Query: 11 EEAPRAAAALCTLYHEAGQRLR----RLQDQLAARDALIARLRARLAALEGDAAPSLVDA 66
E+A AA L E +R R R+Q LAA + + +A L +E + A
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER------LKA 2016
Query: 67 LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEE---------KEREMQQLLSQPQH 117
+E+ R RE R ++ A + Q+ QE + + EE KE+E+QQ L Q Q
Sbjct: 2017 KVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074
Query: 118 EREK---EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE 174
++ E RR+ E E AR ++ E Q RR + + Q +
Sbjct: 2075 VLDQLRGEAEAARRAAEEAEEARVQAE-------REAAQSRRQVEEAERLKQSAEEQAQA 2127
Query: 175 RQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLN------AKWQ 228
R AQ E+ ++E Q + Q E L+QK ++ +
Sbjct: 2128 RAQAQA-AAEKLRKEAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Query: 229 RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288
R A ++ + L QL + H+ L+ +E+ RL + E ++V++EL + R
Sbjct: 2179 RQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236
Query: 289 RD--AALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEE 329
+ + L+ E + L +D ++R +E A+ Q EE
Sbjct: 2237 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279
Score = 57.8 bits (138), Expect = 2e-08
Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 43/360 (11%)
Query: 29 QRLRRLQDQLAARDALIARLRARLAAL---EGDAAPSLVDALLEQVARFREQLRRQEGGA 85
+ L ++ Q+ L AR+ A AL + D + E++ + E+ R A
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2287
Query: 86 AEA----QMRQEIERLTERLEEK--EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAA 139
EA Q+ +E L EK + +MQ + + + E E++ ++ +A+ + R
Sbjct: 2288 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2347
Query: 140 SDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG-- 195
D + + LA ET +RTL A Q + E + + V E S Q+ +
Sbjct: 2348 EDKEQMAQQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2404
Query: 196 --HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
+ + EKL ++KVT V+ L + Q Q H+
Sbjct: 2405 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------------QSDHD 2444
Query: 254 PELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR-DAALERVQMLEQQILAYKDDFMS 312
E +R+ I+ L R+ E+ + ++ + +T + + L+ Q L+Q L+ KD +
Sbjct: 2445 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504
Query: 313 ERADRERAQSRIQELEE----KVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368
E+ ++++++L + K L + +Q E + R+ A + A+ +A E
Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2564
Score = 51.6 bits (122), Expect = 1e-06
Identities = 86/341 (25%), Positives = 138/341 (40%), Gaps = 26/341 (7%)
Query: 26 EAGQRLRR-LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84
E +RLRR +QD+ + L +R+ A E +AA AL + E+LR Q
Sbjct: 1494 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRAL-----QALEELRLQ--- 1544
Query: 85 AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG----ERARAAS 140
A EA+ RL + E+ R++Q L Q E E+ R S AE ER+
Sbjct: 1545 AEEAE-----RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1599
Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV- 199
V L E + R A A + A+ ER + N R Q+E S+
Sbjct: 1600 HVAVAQLREEAER-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658
Query: 200 QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259
Q+ EK +EE ++ E+ + + E R L ++ E EL+R
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR- 1717
Query: 260 EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRER 319
L + E+ +++ELA + AA ++ Q LE ++ + + A + R
Sbjct: 1718 ----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1773
Query: 320 AQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360
A+ + EK L + R +A R+ A ++ AK
Sbjct: 1774 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Score = 50.8 bits (120), Expect = 2e-06
Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 32/300 (10%)
Query: 27 AGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAA 86
A ++LR+ +Q AAR R +A AAL A DA +E+ +F EQ RQ+
Sbjct: 2134 AAEKLRKEAEQEAAR-----RAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---- 2181
Query: 87 EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRS 146
AQ+ QE+ L +LEE + + L ++E+ L+ E R R+ + S
Sbjct: 2182 -AQVEQELTTLRLQLEETDHQKNLL--------DEELQRLKAEATEAARQRSQVEEELFS 2232
Query: 147 LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKL 206
+ + +L + ++ A L ++ + QR + E + + + + ++
Sbjct: 2233 VRVQMEELSKLKARIE--AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2290
Query: 207 QEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNR 266
+L ++ + L K + + L A+ LQ + EL +++ RL
Sbjct: 2291 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ--QQKELAQEQARRLQE 2348
Query: 267 QLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326
E+ + Q+LA LE + + ++ A + A+ RAQ+R +E
Sbjct: 2349 DKEQ-------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2401
Score = 50.4 bits (119), Expect = 3e-06
Identities = 84/403 (20%), Positives = 165/403 (40%), Gaps = 32/403 (7%)
Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85
EA +R + + + R+ L + EG A L A +++ R R + ++G
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAET--EQGEQ 1727
Query: 86 AEAQMRQEIERLTERLEEKEREMQQLLSQPQHER-EKEVVLLRRSMAEGERARAASDVLC 144
+ +E+ RL ++ Q+L ++ R E EV+L ++ AE E +R+ S+
Sbjct: 1728 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE-EESRSTSEKSK 1786
Query: 145 RSLANETHQLR---------RTLTATAHMCQHLAK--CLDERQHAQRNVGERSPDQSEHT 193
+ L E + R R L A + LA+ +R A+R + E+ E T
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846
Query: 194 DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
T + +++ + EN L++ ED + +R ++ + +L L+ +
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903
Query: 254 PELMR-----KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308
EL R ++ R RQ+EE+I ++ AA + + L R++ + L K+
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963
Query: 309 DFMSE-------RADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKY 361
E A+ ER + +E +K + + + ++ + + R+ A + A+
Sbjct: 1964 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2023
Query: 362 LAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQ 404
L A + +Q+ E H A Q+ + +LQ
Sbjct: 2024 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2066
Score = 49.3 bits (116), Expect = 7e-06
Identities = 75/329 (22%), Positives = 133/329 (40%), Gaps = 51/329 (15%)
Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ---- 81
EA QR RRL++Q A A I A+L D+ L+E R R Q+ +
Sbjct: 1873 EAFQR-RRLEEQAAQHKADIEERLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILAL 1930
Query: 82 -----EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERA 136
+ A +A++ E+ R+ E+ R +Q E E R+ AE ER
Sbjct: 1931 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA--------ELEAARQRQLAAEEERR 1982
Query: 137 RA-ASDVLCRSLANETHQLRRT---------LTATAHMCQHLAKCLDERQHAQRNVGERS 186
R A + + +SLA E R+ L A + L + ++ Q + + +
Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2042
Query: 187 PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246
+ + +V +K QE + L+Q+ + ++ L + + + +E A+
Sbjct: 2043 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEA 2096
Query: 247 GLQIPHEPELMRKEIS---RLNRQLEEKINDCA-----------EVKQELAASRTARDAA 292
+Q E R+++ RL + EE+ A E +QE A A AA
Sbjct: 2097 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2156
Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQ 321
L + Q + ++ +K +E+ R++AQ
Sbjct: 2157 LRQKQAADAEMEKHKK--FAEQTLRQKAQ 2183
Score = 47.4 bits (111), Expect = 3e-05
Identities = 89/393 (22%), Positives = 165/393 (41%), Gaps = 72/393 (18%)
Query: 33 RLQDQLAARDALIARLRARLAAL---------EGDAAPSLVDALLEQVARFREQL----- 78
RLQ + RD + R R R+A L + D ++ L Q+ +RE
Sbjct: 1162 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1221
Query: 79 ------RRQE---------GGAAEAQMRQE------IERLTERLEEKEREMQQLLSQPQH 117
RRQE A Q+RQE IER E++EE +R +Q ++ +
Sbjct: 1222 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK- 1280
Query: 118 EREKEVVLLR------RSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKC 171
+ E ++V + S A+ + ++ S+ + + + T T+ + +++
Sbjct: 1281 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1340
Query: 172 LDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK---LQEENRLLK-QKVTHVEDLNAKW 227
L + +R ++ ++ E V++ +EK L E + K Q ++L +
Sbjct: 1341 LRRMEEEERLAEQQRAEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1397
Query: 228 QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287
Q R+E Q R +Q +E+ +L + E +I A+ +Q AA R+
Sbjct: 1398 QEEVVRREEAAVDAQQQKRSIQ---------EELQQLRQSSEAEIQ--AKARQAEAAERS 1446
Query: 288 ----ARDAALERVQM--LEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV--- 338
+ + R+Q+ E+Q + + + RA E A+++ ++ +E+ L QV
Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506
Query: 339 SWRQDSREPD-AGRIHAGSKTA--KYLAADALE 368
S R+ E + A R+ A ++ A K A ALE
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALE 1539
Score = 47.0 bits (110), Expect = 3e-05
Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 46/353 (13%)
Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIAR--LRARLAAL-EGDAAPSLVDAL 67
EEA R + A + RLR+L ++ A+ +A L+ ++ A+ E + + L
Sbjct: 2278 EEAARLSVAA-----QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2332
Query: 68 LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124
+Q +EQ RR ++++ E++ ++L E+ + Q+ L Q Q E E
Sbjct: 2333 QQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2383
Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184
L+ +AE RA+A ++ + + ++ L T Q L + QR +
Sbjct: 2384 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSD 2442
Query: 185 RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW--QRYNASRDEYVRGLH 242
D + ++ EKLQ+E +LL+ K ++ + + Q A + ++
Sbjct: 2443 H--DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2500
Query: 243 AQLRGLQIPHEP-----ELMRKEISRLNRQLEEKINDCAEVKQE----LAASRTAR---- 289
+ L+ + + +L + E+++ + EE+ +++QE +A+ AR
Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2560
Query: 290 ------DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
E +Q LEQQ +++ ++E R R Q ++ E E+ A+L H
Sbjct: 2561 EAEEGVRRKQEELQQLEQQ-RRQQEELLAEENQRLREQLQLLE-EQHRAALAH 2611
Score = 46.2 bits (108), Expect = 6e-05
Identities = 98/393 (24%), Positives = 156/393 (39%), Gaps = 42/393 (10%)
Query: 62 SLVDALLEQVARF-REQLRR--QEGGAAEAQMRQEIERLTE--RLEEKEREMQQLLSQPQ 116
S + L Q +F E LRR +E AE Q +E ERL E EK+R++ + +Q +
Sbjct: 1324 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1383
Query: 117 HEREKEVVLLRRSMAEG----ERARAASDVLCRSLANETHQLRRTLTA-------TAHMC 165
+ E+E L++ M E E A + RS+ E QLR++ A A
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1443
Query: 166 QHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225
+ ++E R E + Q +G +Q++ + +E +Q E L
Sbjct: 1444 ERSRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRR 1501
Query: 226 KWQRYNASRDEYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAA 284
+ Q DE R A++ ++ E E R E R + LEE E ++ L
Sbjct: 1502 QVQ------DESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1554
Query: 285 SRTAR----DAALERVQ-MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339
+ R ALE Q E ++ + + F + A ER+ +QE VA L +
Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAE 1611
Query: 340 WR-QDSREPDAGRIHAGSKTAKY--LAADALELMVPG---GWRPGTGSQQPEPPAEGGHP 393
R Q E + R A + ++ A +AL L + + + E E
Sbjct: 1612 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671
Query: 394 GAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAE 426
A +RG+ + Q Q EQ E R +AE
Sbjct: 1672 EARRRGKAEEQAVR--QRELAEQELEKQRQLAE 1702
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 60.5 bits (145), Expect = 3e-09
Identities = 84/343 (24%), Positives = 141/343 (41%), Gaps = 50/343 (14%)
Query: 11 EEAPRAAAALCTLYHEAGQRLR----RLQDQLAARDALIARLRARLAALEGDAAPSLVDA 66
E+A AA L E +R R R+Q LAA + + +A L +E + A
Sbjct: 1967 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER------LKA 2020
Query: 67 LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEE---------KEREMQQLLSQPQH 117
+E+ R RE R ++ A + Q+ QE + + EE KE+E+QQ L Q Q
Sbjct: 2021 KVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2078
Query: 118 EREK---EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE 174
++ E RR+ E E AR ++ E Q RR + + Q +
Sbjct: 2079 VLDQLRGEAEAARRAAEEAEEARVQAE-------REAAQSRRQVEEAERLKQSAEEQAQA 2131
Query: 175 RQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLN------AKWQ 228
R AQ E+ ++E Q + Q E L+QK ++ +
Sbjct: 2132 RAQAQA-AAEKLRKEAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2182
Query: 229 RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288
R A ++ + L QL + H+ L+ +E+ RL + E ++V++EL + R
Sbjct: 2183 RQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2240
Query: 289 RD--AALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEE 329
+ + L+ E + L +D ++R +E A+ Q EE
Sbjct: 2241 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2283
Score = 57.8 bits (138), Expect = 2e-08
Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 43/360 (11%)
Query: 29 QRLRRLQDQLAARDALIARLRARLAAL---EGDAAPSLVDALLEQVARFREQLRRQEGGA 85
+ L ++ Q+ L AR+ A AL + D + E++ + E+ R A
Sbjct: 2232 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2291
Query: 86 AEA----QMRQEIERLTERLEEK--EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAA 139
EA Q+ +E L EK + +MQ + + + E E++ ++ +A+ + R
Sbjct: 2292 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2351
Query: 140 SDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG-- 195
D + + LA ET +RTL A Q + E + + V E S Q+ +
Sbjct: 2352 EDKEQMAQQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2408
Query: 196 --HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
+ + EKL ++KVT V+ L + Q Q H+
Sbjct: 2409 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------------QSDHD 2448
Query: 254 PELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR-DAALERVQMLEQQILAYKDDFMS 312
E +R+ I+ L R+ E+ + ++ + +T + + L+ Q L+Q L+ KD +
Sbjct: 2449 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2508
Query: 313 ERADRERAQSRIQELEE----KVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368
E+ ++++++L + K L + +Q E + R+ A + A+ +A E
Sbjct: 2509 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2568
Score = 51.6 bits (122), Expect = 1e-06
Identities = 86/341 (25%), Positives = 138/341 (40%), Gaps = 26/341 (7%)
Query: 26 EAGQRLRR-LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84
E +RLRR +QD+ + L +R+ A E +AA AL + E+LR Q
Sbjct: 1498 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRAL-----QALEELRLQ--- 1548
Query: 85 AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG----ERARAAS 140
A EA+ RL + E+ R++Q L Q E E+ R S AE ER+
Sbjct: 1549 AEEAE-----RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1603
Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV- 199
V L E + R A A + A+ ER + N R Q+E S+
Sbjct: 1604 HVAVAQLREEAER-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1662
Query: 200 QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259
Q+ EK +EE ++ E+ + + E R L ++ E EL+R
Sbjct: 1663 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR- 1721
Query: 260 EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRER 319
L + E+ +++ELA + AA ++ Q LE ++ + + A + R
Sbjct: 1722 ----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1777
Query: 320 AQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360
A+ + EK L + R +A R+ A ++ AK
Sbjct: 1778 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1818
Score = 50.8 bits (120), Expect = 2e-06
Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 32/300 (10%)
Query: 27 AGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAA 86
A ++LR+ +Q AAR R +A AAL A DA +E+ +F EQ RQ+
Sbjct: 2138 AAEKLRKEAEQEAAR-----RAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---- 2185
Query: 87 EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRS 146
AQ+ QE+ L +LEE + + L ++E+ L+ E R R+ + S
Sbjct: 2186 -AQVEQELTTLRLQLEETDHQKNLL--------DEELQRLKAEATEAARQRSQVEEELFS 2236
Query: 147 LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKL 206
+ + +L + ++ A L ++ + QR + E + + + + ++
Sbjct: 2237 VRVQMEELSKLKARIE--AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2294
Query: 207 QEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNR 266
+L ++ + L K + + L A+ LQ + EL +++ RL
Sbjct: 2295 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ--QQKELAQEQARRLQE 2352
Query: 267 QLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326
E+ + Q+LA LE + + ++ A + A+ RAQ+R +E
Sbjct: 2353 DKEQ-------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2405
Score = 50.4 bits (119), Expect = 3e-06
Identities = 84/403 (20%), Positives = 165/403 (40%), Gaps = 32/403 (7%)
Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85
EA +R + + + R+ L + EG A L A +++ R R + ++G
Sbjct: 1676 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAET--EQGEQ 1731
Query: 86 AEAQMRQEIERLTERLEEKEREMQQLLSQPQHER-EKEVVLLRRSMAEGERARAASDVLC 144
+ +E+ RL ++ Q+L ++ R E EV+L ++ AE E +R+ S+
Sbjct: 1732 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE-EESRSTSEKSK 1790
Query: 145 RSLANETHQLR---------RTLTATAHMCQHLAK--CLDERQHAQRNVGERSPDQSEHT 193
+ L E + R R L A + LA+ +R A+R + E+ E T
Sbjct: 1791 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1850
Query: 194 DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
T + +++ + EN L++ ED + +R ++ + +L L+ +
Sbjct: 1851 RLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1907
Query: 254 PELMR-----KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308
EL R ++ R RQ+EE+I ++ AA + + L R++ + L K+
Sbjct: 1908 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1967
Query: 309 DFMSE-------RADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKY 361
E A+ ER + +E +K + + + ++ + + R+ A + A+
Sbjct: 1968 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2027
Query: 362 LAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQ 404
L A + +Q+ E H A Q+ + +LQ
Sbjct: 2028 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2070
Score = 49.3 bits (116), Expect = 7e-06
Identities = 75/329 (22%), Positives = 133/329 (40%), Gaps = 51/329 (15%)
Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ---- 81
EA QR RRL++Q A A I A+L D+ L+E R R Q+ +
Sbjct: 1877 EAFQR-RRLEEQAAQHKADIEERLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILAL 1934
Query: 82 -----EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERA 136
+ A +A++ E+ R+ E+ R +Q E E R+ AE ER
Sbjct: 1935 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA--------ELEAARQRQLAAEEERR 1986
Query: 137 RA-ASDVLCRSLANETHQLRRT---------LTATAHMCQHLAKCLDERQHAQRNVGERS 186
R A + + +SLA E R+ L A + L + ++ Q + + +
Sbjct: 1987 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2046
Query: 187 PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246
+ + +V +K QE + L+Q+ + ++ L + + + +E A+
Sbjct: 2047 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEA 2100
Query: 247 GLQIPHEPELMRKEIS---RLNRQLEEKINDCA-----------EVKQELAASRTARDAA 292
+Q E R+++ RL + EE+ A E +QE A A AA
Sbjct: 2101 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2160
Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQ 321
L + Q + ++ +K +E+ R++AQ
Sbjct: 2161 LRQKQAADAEMEKHKK--FAEQTLRQKAQ 2187
Score = 47.4 bits (111), Expect = 3e-05
Identities = 89/393 (22%), Positives = 165/393 (41%), Gaps = 72/393 (18%)
Query: 33 RLQDQLAARDALIARLRARLAAL---------EGDAAPSLVDALLEQVARFREQL----- 78
RLQ + RD + R R R+A L + D ++ L Q+ +RE
Sbjct: 1166 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1225
Query: 79 ------RRQE---------GGAAEAQMRQE------IERLTERLEEKEREMQQLLSQPQH 117
RRQE A Q+RQE IER E++EE +R +Q ++ +
Sbjct: 1226 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK- 1284
Query: 118 EREKEVVLLR------RSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKC 171
+ E ++V + S A+ + ++ S+ + + + T T+ + +++
Sbjct: 1285 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1344
Query: 172 LDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK---LQEENRLLK-QKVTHVEDLNAKW 227
L + +R ++ ++ E V++ +EK L E + K Q ++L +
Sbjct: 1345 LRRMEEEERLAEQQRAEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1401
Query: 228 QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287
Q R+E Q R +Q +E+ +L + E +I A+ +Q AA R+
Sbjct: 1402 QEEVVRREEAAVDAQQQKRSIQ---------EELQQLRQSSEAEIQ--AKARQAEAAERS 1450
Query: 288 ----ARDAALERVQM--LEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV--- 338
+ + R+Q+ E+Q + + + RA E A+++ ++ +E+ L QV
Sbjct: 1451 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1510
Query: 339 SWRQDSREPD-AGRIHAGSKTA--KYLAADALE 368
S R+ E + A R+ A ++ A K A ALE
Sbjct: 1511 SQRKRQAEVELASRVKAEAEAAREKQRALQALE 1543
Score = 47.0 bits (110), Expect = 3e-05
Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 46/353 (13%)
Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIAR--LRARLAAL-EGDAAPSLVDAL 67
EEA R + A + RLR+L ++ A+ +A L+ ++ A+ E + + L
Sbjct: 2282 EEAARLSVAA-----QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2336
Query: 68 LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124
+Q +EQ RR ++++ E++ ++L E+ + Q+ L Q Q E E
Sbjct: 2337 QQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2387
Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184
L+ +AE RA+A ++ + + ++ L T Q L + QR +
Sbjct: 2388 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSD 2446
Query: 185 RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW--QRYNASRDEYVRGLH 242
D + ++ EKLQ+E +LL+ K ++ + + Q A + ++
Sbjct: 2447 H--DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2504
Query: 243 AQLRGLQIPHEP-----ELMRKEISRLNRQLEEKINDCAEVKQE----LAASRTAR---- 289
+ L+ + + +L + E+++ + EE+ +++QE +A+ AR
Sbjct: 2505 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2564
Query: 290 ------DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
E +Q LEQQ +++ ++E R R Q ++ E E+ A+L H
Sbjct: 2565 EAEEGVRRKQEELQQLEQQ-RRQQEELLAEENQRLREQLQLLE-EQHRAALAH 2615
Score = 46.2 bits (108), Expect = 6e-05
Identities = 98/393 (24%), Positives = 156/393 (39%), Gaps = 42/393 (10%)
Query: 62 SLVDALLEQVARF-REQLRR--QEGGAAEAQMRQEIERLTE--RLEEKEREMQQLLSQPQ 116
S + L Q +F E LRR +E AE Q +E ERL E EK+R++ + +Q +
Sbjct: 1328 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1387
Query: 117 HEREKEVVLLRRSMAEG----ERARAASDVLCRSLANETHQLRRTLTA-------TAHMC 165
+ E+E L++ M E E A + RS+ E QLR++ A A
Sbjct: 1388 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1447
Query: 166 QHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225
+ ++E R E + Q +G +Q++ + +E +Q E L
Sbjct: 1448 ERSRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRR 1505
Query: 226 KWQRYNASRDEYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAA 284
+ Q DE R A++ ++ E E R E R + LEE E ++ L
Sbjct: 1506 QVQ------DESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1558
Query: 285 SRTAR----DAALERVQ-MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339
+ R ALE Q E ++ + + F + A ER+ +QE VA L +
Sbjct: 1559 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAE 1615
Query: 340 WR-QDSREPDAGRIHAGSKTAKY--LAADALELMVPG---GWRPGTGSQQPEPPAEGGHP 393
R Q E + R A + ++ A +AL L + + + E E
Sbjct: 1616 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1675
Query: 394 GAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAE 426
A +RG+ + Q Q EQ E R +AE
Sbjct: 1676 EARRRGKAEEQAVR--QRELAEQELEKQRQLAE 1706
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 60.5 bits (145), Expect = 3e-09
Identities = 84/343 (24%), Positives = 141/343 (41%), Gaps = 50/343 (14%)
Query: 11 EEAPRAAAALCTLYHEAGQRLR----RLQDQLAARDALIARLRARLAALEGDAAPSLVDA 66
E+A AA L E +R R R+Q LAA + + +A L +E + A
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER------LKA 2016
Query: 67 LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEE---------KEREMQQLLSQPQH 117
+E+ R RE R ++ A + Q+ QE + + EE KE+E+QQ L Q Q
Sbjct: 2017 KVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074
Query: 118 EREK---EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE 174
++ E RR+ E E AR ++ E Q RR + + Q +
Sbjct: 2075 VLDQLRGEAEAARRAAEEAEEARVQAE-------REAAQSRRQVEEAERLKQSAEEQAQA 2127
Query: 175 RQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLN------AKWQ 228
R AQ E+ ++E Q + Q E L+QK ++ +
Sbjct: 2128 RAQAQA-AAEKLRKEAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Query: 229 RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288
R A ++ + L QL + H+ L+ +E+ RL + E ++V++EL + R
Sbjct: 2179 RQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236
Query: 289 RD--AALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEE 329
+ + L+ E + L +D ++R +E A+ Q EE
Sbjct: 2237 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279
Score = 57.8 bits (138), Expect = 2e-08
Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 43/360 (11%)
Query: 29 QRLRRLQDQLAARDALIARLRARLAAL---EGDAAPSLVDALLEQVARFREQLRRQEGGA 85
+ L ++ Q+ L AR+ A AL + D + E++ + E+ R A
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2287
Query: 86 AEA----QMRQEIERLTERLEEK--EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAA 139
EA Q+ +E L EK + +MQ + + + E E++ ++ +A+ + R
Sbjct: 2288 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2347
Query: 140 SDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG-- 195
D + + LA ET +RTL A Q + E + + V E S Q+ +
Sbjct: 2348 EDKEQMAQQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2404
Query: 196 --HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
+ + EKL ++KVT V+ L + Q Q H+
Sbjct: 2405 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------------QSDHD 2444
Query: 254 PELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR-DAALERVQMLEQQILAYKDDFMS 312
E +R+ I+ L R+ E+ + ++ + +T + + L+ Q L+Q L+ KD +
Sbjct: 2445 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504
Query: 313 ERADRERAQSRIQELEE----KVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368
E+ ++++++L + K L + +Q E + R+ A + A+ +A E
Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2564
Score = 51.6 bits (122), Expect = 1e-06
Identities = 86/341 (25%), Positives = 138/341 (40%), Gaps = 26/341 (7%)
Query: 26 EAGQRLRR-LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84
E +RLRR +QD+ + L +R+ A E +AA AL + E+LR Q
Sbjct: 1494 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRAL-----QALEELRLQ--- 1544
Query: 85 AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG----ERARAAS 140
A EA+ RL + E+ R++Q L Q E E+ R S AE ER+
Sbjct: 1545 AEEAE-----RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1599
Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV- 199
V L E + R A A + A+ ER + N R Q+E S+
Sbjct: 1600 HVAVAQLREEAER-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658
Query: 200 QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259
Q+ EK +EE ++ E+ + + E R L ++ E EL+R
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR- 1717
Query: 260 EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRER 319
L + E+ +++ELA + AA ++ Q LE ++ + + A + R
Sbjct: 1718 ----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1773
Query: 320 AQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360
A+ + EK L + R +A R+ A ++ AK
Sbjct: 1774 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Score = 50.8 bits (120), Expect = 2e-06
Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 32/300 (10%)
Query: 27 AGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAA 86
A ++LR+ +Q AAR R +A AAL A DA +E+ +F EQ RQ+
Sbjct: 2134 AAEKLRKEAEQEAAR-----RAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---- 2181
Query: 87 EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRS 146
AQ+ QE+ L +LEE + + L ++E+ L+ E R R+ + S
Sbjct: 2182 -AQVEQELTTLRLQLEETDHQKNLL--------DEELQRLKAEATEAARQRSQVEEELFS 2232
Query: 147 LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKL 206
+ + +L + ++ A L ++ + QR + E + + + + ++
Sbjct: 2233 VRVQMEELSKLKARIE--AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2290
Query: 207 QEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNR 266
+L ++ + L K + + L A+ LQ + EL +++ RL
Sbjct: 2291 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ--QQKELAQEQARRLQE 2348
Query: 267 QLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326
E+ + Q+LA LE + + ++ A + A+ RAQ+R +E
Sbjct: 2349 DKEQ-------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2401
Score = 50.4 bits (119), Expect = 3e-06
Identities = 84/403 (20%), Positives = 165/403 (40%), Gaps = 32/403 (7%)
Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85
EA +R + + + R+ L + EG A L A +++ R R + ++G
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAET--EQGEQ 1727
Query: 86 AEAQMRQEIERLTERLEEKEREMQQLLSQPQHER-EKEVVLLRRSMAEGERARAASDVLC 144
+ +E+ RL ++ Q+L ++ R E EV+L ++ AE E +R+ S+
Sbjct: 1728 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE-EESRSTSEKSK 1786
Query: 145 RSLANETHQLR---------RTLTATAHMCQHLAK--CLDERQHAQRNVGERSPDQSEHT 193
+ L E + R R L A + LA+ +R A+R + E+ E T
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846
Query: 194 DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
T + +++ + EN L++ ED + +R ++ + +L L+ +
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903
Query: 254 PELMR-----KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308
EL R ++ R RQ+EE+I ++ AA + + L R++ + L K+
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963
Query: 309 DFMSE-------RADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKY 361
E A+ ER + +E +K + + + ++ + + R+ A + A+
Sbjct: 1964 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2023
Query: 362 LAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQ 404
L A + +Q+ E H A Q+ + +LQ
Sbjct: 2024 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2066
Score = 49.3 bits (116), Expect = 7e-06
Identities = 75/329 (22%), Positives = 133/329 (40%), Gaps = 51/329 (15%)
Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ---- 81
EA QR RRL++Q A A I A+L D+ L+E R R Q+ +
Sbjct: 1873 EAFQR-RRLEEQAAQHKADIEERLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILAL 1930
Query: 82 -----EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERA 136
+ A +A++ E+ R+ E+ R +Q E E R+ AE ER
Sbjct: 1931 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA--------ELEAARQRQLAAEEERR 1982
Query: 137 RA-ASDVLCRSLANETHQLRRT---------LTATAHMCQHLAKCLDERQHAQRNVGERS 186
R A + + +SLA E R+ L A + L + ++ Q + + +
Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2042
Query: 187 PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246
+ + +V +K QE + L+Q+ + ++ L + + + +E A+
Sbjct: 2043 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEA 2096
Query: 247 GLQIPHEPELMRKEIS---RLNRQLEEKINDCA-----------EVKQELAASRTARDAA 292
+Q E R+++ RL + EE+ A E +QE A A AA
Sbjct: 2097 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2156
Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQ 321
L + Q + ++ +K +E+ R++AQ
Sbjct: 2157 LRQKQAADAEMEKHKK--FAEQTLRQKAQ 2183
Score = 47.4 bits (111), Expect = 3e-05
Identities = 89/393 (22%), Positives = 165/393 (41%), Gaps = 72/393 (18%)
Query: 33 RLQDQLAARDALIARLRARLAAL---------EGDAAPSLVDALLEQVARFREQL----- 78
RLQ + RD + R R R+A L + D ++ L Q+ +RE
Sbjct: 1162 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1221
Query: 79 ------RRQE---------GGAAEAQMRQE------IERLTERLEEKEREMQQLLSQPQH 117
RRQE A Q+RQE IER E++EE +R +Q ++ +
Sbjct: 1222 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK- 1280
Query: 118 EREKEVVLLR------RSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKC 171
+ E ++V + S A+ + ++ S+ + + + T T+ + +++
Sbjct: 1281 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1340
Query: 172 LDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK---LQEENRLLK-QKVTHVEDLNAKW 227
L + +R ++ ++ E V++ +EK L E + K Q ++L +
Sbjct: 1341 LRRMEEEERLAEQQRAEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1397
Query: 228 QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287
Q R+E Q R +Q +E+ +L + E +I A+ +Q AA R+
Sbjct: 1398 QEEVVRREEAAVDAQQQKRSIQ---------EELQQLRQSSEAEIQ--AKARQAEAAERS 1446
Query: 288 ----ARDAALERVQM--LEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV--- 338
+ + R+Q+ E+Q + + + RA E A+++ ++ +E+ L QV
Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506
Query: 339 SWRQDSREPD-AGRIHAGSKTA--KYLAADALE 368
S R+ E + A R+ A ++ A K A ALE
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALE 1539
Score = 47.0 bits (110), Expect = 3e-05
Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 46/353 (13%)
Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIAR--LRARLAAL-EGDAAPSLVDAL 67
EEA R + A + RLR+L ++ A+ +A L+ ++ A+ E + + L
Sbjct: 2278 EEAARLSVAA-----QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2332
Query: 68 LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124
+Q +EQ RR ++++ E++ ++L E+ + Q+ L Q Q E E
Sbjct: 2333 QQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2383
Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184
L+ +AE RA+A ++ + + ++ L T Q L + QR +
Sbjct: 2384 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSD 2442
Query: 185 RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW--QRYNASRDEYVRGLH 242
D + ++ EKLQ+E +LL+ K ++ + + Q A + ++
Sbjct: 2443 H--DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2500
Query: 243 AQLRGLQIPHEP-----ELMRKEISRLNRQLEEKINDCAEVKQE----LAASRTAR---- 289
+ L+ + + +L + E+++ + EE+ +++QE +A+ AR
Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2560
Query: 290 ------DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
E +Q LEQQ +++ ++E R R Q ++ E E+ A+L H
Sbjct: 2561 EAEEGVRRKQEELQQLEQQ-RRQQEELLAEENQRLREQLQLLE-EQHRAALAH 2611
Score = 46.2 bits (108), Expect = 6e-05
Identities = 98/393 (24%), Positives = 156/393 (39%), Gaps = 42/393 (10%)
Query: 62 SLVDALLEQVARF-REQLRR--QEGGAAEAQMRQEIERLTE--RLEEKEREMQQLLSQPQ 116
S + L Q +F E LRR +E AE Q +E ERL E EK+R++ + +Q +
Sbjct: 1324 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1383
Query: 117 HEREKEVVLLRRSMAEG----ERARAASDVLCRSLANETHQLRRTLTA-------TAHMC 165
+ E+E L++ M E E A + RS+ E QLR++ A A
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1443
Query: 166 QHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225
+ ++E R E + Q +G +Q++ + +E +Q E L
Sbjct: 1444 ERSRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRR 1501
Query: 226 KWQRYNASRDEYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAA 284
+ Q DE R A++ ++ E E R E R + LEE E ++ L
Sbjct: 1502 QVQ------DESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1554
Query: 285 SRTAR----DAALERVQ-MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339
+ R ALE Q E ++ + + F + A ER+ +QE VA L +
Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAE 1611
Query: 340 WR-QDSREPDAGRIHAGSKTAKY--LAADALELMVPG---GWRPGTGSQQPEPPAEGGHP 393
R Q E + R A + ++ A +AL L + + + E E
Sbjct: 1612 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671
Query: 394 GAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAE 426
A +RG+ + Q Q EQ E R +AE
Sbjct: 1672 EARRRGKAEEQAVR--QRELAEQELEKQRQLAE 1702
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 60.5 bits (145), Expect = 3e-09
Identities = 84/343 (24%), Positives = 141/343 (41%), Gaps = 50/343 (14%)
Query: 11 EEAPRAAAALCTLYHEAGQRLR----RLQDQLAARDALIARLRARLAALEGDAAPSLVDA 66
E+A AA L E +R R R+Q LAA + + +A L +E + A
Sbjct: 1931 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER------LKA 1984
Query: 67 LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEE---------KEREMQQLLSQPQH 117
+E+ R RE R ++ A + Q+ QE + + EE KE+E+QQ L Q Q
Sbjct: 1985 KVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2042
Query: 118 EREK---EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE 174
++ E RR+ E E AR ++ E Q RR + + Q +
Sbjct: 2043 VLDQLRGEAEAARRAAEEAEEARVQAE-------REAAQSRRQVEEAERLKQSAEEQAQA 2095
Query: 175 RQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLN------AKWQ 228
R AQ E+ ++E Q + Q E L+QK ++ +
Sbjct: 2096 RAQAQA-AAEKLRKEAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2146
Query: 229 RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288
R A ++ + L QL + H+ L+ +E+ RL + E ++V++EL + R
Sbjct: 2147 RQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2204
Query: 289 RD--AALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEE 329
+ + L+ E + L +D ++R +E A+ Q EE
Sbjct: 2205 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2247
Score = 57.8 bits (138), Expect = 2e-08
Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 43/360 (11%)
Query: 29 QRLRRLQDQLAARDALIARLRARLAAL---EGDAAPSLVDALLEQVARFREQLRRQEGGA 85
+ L ++ Q+ L AR+ A AL + D + E++ + E+ R A
Sbjct: 2196 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2255
Query: 86 AEA----QMRQEIERLTERLEEK--EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAA 139
EA Q+ +E L EK + +MQ + + + E E++ ++ +A+ + R
Sbjct: 2256 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2315
Query: 140 SDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG-- 195
D + + LA ET +RTL A Q + E + + V E S Q+ +
Sbjct: 2316 EDKEQMAQQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2372
Query: 196 --HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
+ + EKL ++KVT V+ L + Q Q H+
Sbjct: 2373 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------------QSDHD 2412
Query: 254 PELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR-DAALERVQMLEQQILAYKDDFMS 312
E +R+ I+ L R+ E+ + ++ + +T + + L+ Q L+Q L+ KD +
Sbjct: 2413 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2472
Query: 313 ERADRERAQSRIQELEE----KVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368
E+ ++++++L + K L + +Q E + R+ A + A+ +A E
Sbjct: 2473 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2532
Score = 51.6 bits (122), Expect = 1e-06
Identities = 86/341 (25%), Positives = 138/341 (40%), Gaps = 26/341 (7%)
Query: 26 EAGQRLRR-LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84
E +RLRR +QD+ + L +R+ A E +AA AL + E+LR Q
Sbjct: 1462 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRAL-----QALEELRLQ--- 1512
Query: 85 AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG----ERARAAS 140
A EA+ RL + E+ R++Q L Q E E+ R S AE ER+
Sbjct: 1513 AEEAE-----RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1567
Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV- 199
V L E + R A A + A+ ER + N R Q+E S+
Sbjct: 1568 HVAVAQLREEAER-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1626
Query: 200 QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259
Q+ EK +EE ++ E+ + + E R L ++ E EL+R
Sbjct: 1627 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR- 1685
Query: 260 EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRER 319
L + E+ +++ELA + AA ++ Q LE ++ + + A + R
Sbjct: 1686 ----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1741
Query: 320 AQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360
A+ + EK L + R +A R+ A ++ AK
Sbjct: 1742 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1782
Score = 50.8 bits (120), Expect = 2e-06
Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 32/300 (10%)
Query: 27 AGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAA 86
A ++LR+ +Q AAR R +A AAL A DA +E+ +F EQ RQ+
Sbjct: 2102 AAEKLRKEAEQEAAR-----RAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---- 2149
Query: 87 EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRS 146
AQ+ QE+ L +LEE + + L ++E+ L+ E R R+ + S
Sbjct: 2150 -AQVEQELTTLRLQLEETDHQKNLL--------DEELQRLKAEATEAARQRSQVEEELFS 2200
Query: 147 LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKL 206
+ + +L + ++ A L ++ + QR + E + + + + ++
Sbjct: 2201 VRVQMEELSKLKARIE--AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2258
Query: 207 QEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNR 266
+L ++ + L K + + L A+ LQ + EL +++ RL
Sbjct: 2259 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ--QQKELAQEQARRLQE 2316
Query: 267 QLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326
E+ + Q+LA LE + + ++ A + A+ RAQ+R +E
Sbjct: 2317 DKEQ-------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2369
Score = 50.4 bits (119), Expect = 3e-06
Identities = 84/403 (20%), Positives = 165/403 (40%), Gaps = 32/403 (7%)
Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85
EA +R + + + R+ L + EG A L A +++ R R + ++G
Sbjct: 1640 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAET--EQGEQ 1695
Query: 86 AEAQMRQEIERLTERLEEKEREMQQLLSQPQHER-EKEVVLLRRSMAEGERARAASDVLC 144
+ +E+ RL ++ Q+L ++ R E EV+L ++ AE E +R+ S+
Sbjct: 1696 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE-EESRSTSEKSK 1754
Query: 145 RSLANETHQLR---------RTLTATAHMCQHLAK--CLDERQHAQRNVGERSPDQSEHT 193
+ L E + R R L A + LA+ +R A+R + E+ E T
Sbjct: 1755 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1814
Query: 194 DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
T + +++ + EN L++ ED + +R ++ + +L L+ +
Sbjct: 1815 RLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1871
Query: 254 PELMR-----KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308
EL R ++ R RQ+EE+I ++ AA + + L R++ + L K+
Sbjct: 1872 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1931
Query: 309 DFMSE-------RADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKY 361
E A+ ER + +E +K + + + ++ + + R+ A + A+
Sbjct: 1932 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 1991
Query: 362 LAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQ 404
L A + +Q+ E H A Q+ + +LQ
Sbjct: 1992 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2034
Score = 49.3 bits (116), Expect = 7e-06
Identities = 75/329 (22%), Positives = 133/329 (40%), Gaps = 51/329 (15%)
Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ---- 81
EA QR RRL++Q A A I A+L D+ L+E R R Q+ +
Sbjct: 1841 EAFQR-RRLEEQAAQHKADIEERLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILAL 1898
Query: 82 -----EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERA 136
+ A +A++ E+ R+ E+ R +Q E E R+ AE ER
Sbjct: 1899 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA--------ELEAARQRQLAAEEERR 1950
Query: 137 RA-ASDVLCRSLANETHQLRRT---------LTATAHMCQHLAKCLDERQHAQRNVGERS 186
R A + + +SLA E R+ L A + L + ++ Q + + +
Sbjct: 1951 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2010
Query: 187 PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246
+ + +V +K QE + L+Q+ + ++ L + + + +E A+
Sbjct: 2011 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEA 2064
Query: 247 GLQIPHEPELMRKEIS---RLNRQLEEKINDCA-----------EVKQELAASRTARDAA 292
+Q E R+++ RL + EE+ A E +QE A A AA
Sbjct: 2065 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2124
Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQ 321
L + Q + ++ +K +E+ R++AQ
Sbjct: 2125 LRQKQAADAEMEKHKK--FAEQTLRQKAQ 2151
Score = 47.4 bits (111), Expect = 3e-05
Identities = 89/393 (22%), Positives = 165/393 (41%), Gaps = 72/393 (18%)
Query: 33 RLQDQLAARDALIARLRARLAAL---------EGDAAPSLVDALLEQVARFREQL----- 78
RLQ + RD + R R R+A L + D ++ L Q+ +RE
Sbjct: 1130 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1189
Query: 79 ------RRQE---------GGAAEAQMRQE------IERLTERLEEKEREMQQLLSQPQH 117
RRQE A Q+RQE IER E++EE +R +Q ++ +
Sbjct: 1190 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK- 1248
Query: 118 EREKEVVLLR------RSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKC 171
+ E ++V + S A+ + ++ S+ + + + T T+ + +++
Sbjct: 1249 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1308
Query: 172 LDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK---LQEENRLLK-QKVTHVEDLNAKW 227
L + +R ++ ++ E V++ +EK L E + K Q ++L +
Sbjct: 1309 LRRMEEEERLAEQQRAEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1365
Query: 228 QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287
Q R+E Q R +Q +E+ +L + E +I A+ +Q AA R+
Sbjct: 1366 QEEVVRREEAAVDAQQQKRSIQ---------EELQQLRQSSEAEIQ--AKARQAEAAERS 1414
Query: 288 ----ARDAALERVQM--LEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV--- 338
+ + R+Q+ E+Q + + + RA E A+++ ++ +E+ L QV
Sbjct: 1415 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1474
Query: 339 SWRQDSREPD-AGRIHAGSKTA--KYLAADALE 368
S R+ E + A R+ A ++ A K A ALE
Sbjct: 1475 SQRKRQAEVELASRVKAEAEAAREKQRALQALE 1507
Score = 47.0 bits (110), Expect = 3e-05
Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 46/353 (13%)
Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIAR--LRARLAAL-EGDAAPSLVDAL 67
EEA R + A + RLR+L ++ A+ +A L+ ++ A+ E + + L
Sbjct: 2246 EEAARLSVAA-----QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2300
Query: 68 LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124
+Q +EQ RR ++++ E++ ++L E+ + Q+ L Q Q E E
Sbjct: 2301 QQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2351
Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184
L+ +AE RA+A ++ + + ++ L T Q L + QR +
Sbjct: 2352 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSD 2410
Query: 185 RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW--QRYNASRDEYVRGLH 242
D + ++ EKLQ+E +LL+ K ++ + + Q A + ++
Sbjct: 2411 H--DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2468
Query: 243 AQLRGLQIPHEP-----ELMRKEISRLNRQLEEKINDCAEVKQE----LAASRTAR---- 289
+ L+ + + +L + E+++ + EE+ +++QE +A+ AR
Sbjct: 2469 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2528
Query: 290 ------DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
E +Q LEQQ +++ ++E R R Q ++ E E+ A+L H
Sbjct: 2529 EAEEGVRRKQEELQQLEQQ-RRQQEELLAEENQRLREQLQLLE-EQHRAALAH 2579
Score = 46.2 bits (108), Expect = 6e-05
Identities = 98/393 (24%), Positives = 156/393 (39%), Gaps = 42/393 (10%)
Query: 62 SLVDALLEQVARF-REQLRR--QEGGAAEAQMRQEIERLTE--RLEEKEREMQQLLSQPQ 116
S + L Q +F E LRR +E AE Q +E ERL E EK+R++ + +Q +
Sbjct: 1292 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1351
Query: 117 HEREKEVVLLRRSMAEG----ERARAASDVLCRSLANETHQLRRTLTA-------TAHMC 165
+ E+E L++ M E E A + RS+ E QLR++ A A
Sbjct: 1352 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1411
Query: 166 QHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225
+ ++E R E + Q +G +Q++ + +E +Q E L
Sbjct: 1412 ERSRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRR 1469
Query: 226 KWQRYNASRDEYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAA 284
+ Q DE R A++ ++ E E R E R + LEE E ++ L
Sbjct: 1470 QVQ------DESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1522
Query: 285 SRTAR----DAALERVQ-MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339
+ R ALE Q E ++ + + F + A ER+ +QE VA L +
Sbjct: 1523 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAE 1579
Query: 340 WR-QDSREPDAGRIHAGSKTAKY--LAADALELMVPG---GWRPGTGSQQPEPPAEGGHP 393
R Q E + R A + ++ A +AL L + + + E E
Sbjct: 1580 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1639
Query: 394 GAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAE 426
A +RG+ + Q Q EQ E R +AE
Sbjct: 1640 EARRRGKAEEQAVR--QRELAEQELEKQRQLAE 1670
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 60.5 bits (145), Expect = 3e-09
Identities = 84/343 (24%), Positives = 141/343 (41%), Gaps = 50/343 (14%)
Query: 11 EEAPRAAAALCTLYHEAGQRLR----RLQDQLAARDALIARLRARLAALEGDAAPSLVDA 66
E+A AA L E +R R R+Q LAA + + +A L +E + A
Sbjct: 2100 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER------LKA 2153
Query: 67 LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEE---------KEREMQQLLSQPQH 117
+E+ R RE R ++ A + Q+ QE + + EE KE+E+QQ L Q Q
Sbjct: 2154 KVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2211
Query: 118 EREK---EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE 174
++ E RR+ E E AR ++ E Q RR + + Q +
Sbjct: 2212 VLDQLRGEAEAARRAAEEAEEARVQAE-------REAAQSRRQVEEAERLKQSAEEQAQA 2264
Query: 175 RQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLN------AKWQ 228
R AQ E+ ++E Q + Q E L+QK ++ +
Sbjct: 2265 RAQAQA-AAEKLRKEAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2315
Query: 229 RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288
R A ++ + L QL + H+ L+ +E+ RL + E ++V++EL + R
Sbjct: 2316 RQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2373
Query: 289 RD--AALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEE 329
+ + L+ E + L +D ++R +E A+ Q EE
Sbjct: 2374 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2416
Score = 57.8 bits (138), Expect = 2e-08
Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 43/360 (11%)
Query: 29 QRLRRLQDQLAARDALIARLRARLAAL---EGDAAPSLVDALLEQVARFREQLRRQEGGA 85
+ L ++ Q+ L AR+ A AL + D + E++ + E+ R A
Sbjct: 2365 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2424
Query: 86 AEA----QMRQEIERLTERLEEK--EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAA 139
EA Q+ +E L EK + +MQ + + + E E++ ++ +A+ + R
Sbjct: 2425 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2484
Query: 140 SDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG-- 195
D + + LA ET +RTL A Q + E + + V E S Q+ +
Sbjct: 2485 EDKEQMAQQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2541
Query: 196 --HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
+ + EKL ++KVT V+ L + Q Q H+
Sbjct: 2542 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------------QSDHD 2581
Query: 254 PELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR-DAALERVQMLEQQILAYKDDFMS 312
E +R+ I+ L R+ E+ + ++ + +T + + L+ Q L+Q L+ KD +
Sbjct: 2582 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2641
Query: 313 ERADRERAQSRIQELEE----KVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368
E+ ++++++L + K L + +Q E + R+ A + A+ +A E
Sbjct: 2642 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2701
Score = 51.6 bits (122), Expect = 1e-06
Identities = 86/341 (25%), Positives = 138/341 (40%), Gaps = 26/341 (7%)
Query: 26 EAGQRLRR-LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84
E +RLRR +QD+ + L +R+ A E +AA AL + E+LR Q
Sbjct: 1631 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRAL-----QALEELRLQ--- 1681
Query: 85 AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG----ERARAAS 140
A EA+ RL + E+ R++Q L Q E E+ R S AE ER+
Sbjct: 1682 AEEAE-----RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1736
Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV- 199
V L E + R A A + A+ ER + N R Q+E S+
Sbjct: 1737 HVAVAQLREEAER-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1795
Query: 200 QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259
Q+ EK +EE ++ E+ + + E R L ++ E EL+R
Sbjct: 1796 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR- 1854
Query: 260 EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRER 319
L + E+ +++ELA + AA ++ Q LE ++ + + A + R
Sbjct: 1855 ----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1910
Query: 320 AQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360
A+ + EK L + R +A R+ A ++ AK
Sbjct: 1911 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1951
Score = 50.8 bits (120), Expect = 2e-06
Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 32/300 (10%)
Query: 27 AGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAA 86
A ++LR+ +Q AAR R +A AAL A DA +E+ +F EQ RQ+
Sbjct: 2271 AAEKLRKEAEQEAAR-----RAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---- 2318
Query: 87 EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRS 146
AQ+ QE+ L +LEE + + L ++E+ L+ E R R+ + S
Sbjct: 2319 -AQVEQELTTLRLQLEETDHQKNLL--------DEELQRLKAEATEAARQRSQVEEELFS 2369
Query: 147 LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKL 206
+ + +L + ++ A L ++ + QR + E + + + + ++
Sbjct: 2370 VRVQMEELSKLKARIE--AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2427
Query: 207 QEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNR 266
+L ++ + L K + + L A+ LQ + EL +++ RL
Sbjct: 2428 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ--QQKELAQEQARRLQE 2485
Query: 267 QLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326
E+ + Q+LA LE + + ++ A + A+ RAQ+R +E
Sbjct: 2486 DKEQ-------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2538
Score = 50.4 bits (119), Expect = 3e-06
Identities = 84/403 (20%), Positives = 165/403 (40%), Gaps = 32/403 (7%)
Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85
EA +R + + + R+ L + EG A L A +++ R R + ++G
Sbjct: 1809 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAET--EQGEQ 1864
Query: 86 AEAQMRQEIERLTERLEEKEREMQQLLSQPQHER-EKEVVLLRRSMAEGERARAASDVLC 144
+ +E+ RL ++ Q+L ++ R E EV+L ++ AE E +R+ S+
Sbjct: 1865 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE-EESRSTSEKSK 1923
Query: 145 RSLANETHQLR---------RTLTATAHMCQHLAK--CLDERQHAQRNVGERSPDQSEHT 193
+ L E + R R L A + LA+ +R A+R + E+ E T
Sbjct: 1924 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1983
Query: 194 DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
T + +++ + EN L++ ED + +R ++ + +L L+ +
Sbjct: 1984 RLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 2040
Query: 254 PELMR-----KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308
EL R ++ R RQ+EE+I ++ AA + + L R++ + L K+
Sbjct: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 2100
Query: 309 DFMSE-------RADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKY 361
E A+ ER + +E +K + + + ++ + + R+ A + A+
Sbjct: 2101 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2160
Query: 362 LAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQ 404
L A + +Q+ E H A Q+ + +LQ
Sbjct: 2161 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2203
Score = 49.3 bits (116), Expect = 7e-06
Identities = 75/329 (22%), Positives = 133/329 (40%), Gaps = 51/329 (15%)
Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ---- 81
EA QR RRL++Q A A I A+L D+ L+E R R Q+ +
Sbjct: 2010 EAFQR-RRLEEQAAQHKADIEERLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILAL 2067
Query: 82 -----EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERA 136
+ A +A++ E+ R+ E+ R +Q E E R+ AE ER
Sbjct: 2068 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA--------ELEAARQRQLAAEEERR 2119
Query: 137 RA-ASDVLCRSLANETHQLRRT---------LTATAHMCQHLAKCLDERQHAQRNVGERS 186
R A + + +SLA E R+ L A + L + ++ Q + + +
Sbjct: 2120 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2179
Query: 187 PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246
+ + +V +K QE + L+Q+ + ++ L + + + +E A+
Sbjct: 2180 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEA 2233
Query: 247 GLQIPHEPELMRKEIS---RLNRQLEEKINDCA-----------EVKQELAASRTARDAA 292
+Q E R+++ RL + EE+ A E +QE A A AA
Sbjct: 2234 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2293
Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQ 321
L + Q + ++ +K +E+ R++AQ
Sbjct: 2294 LRQKQAADAEMEKHKK--FAEQTLRQKAQ 2320
Score = 47.4 bits (111), Expect = 3e-05
Identities = 89/393 (22%), Positives = 165/393 (41%), Gaps = 72/393 (18%)
Query: 33 RLQDQLAARDALIARLRARLAAL---------EGDAAPSLVDALLEQVARFREQL----- 78
RLQ + RD + R R R+A L + D ++ L Q+ +RE
Sbjct: 1299 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1358
Query: 79 ------RRQE---------GGAAEAQMRQE------IERLTERLEEKEREMQQLLSQPQH 117
RRQE A Q+RQE IER E++EE +R +Q ++ +
Sbjct: 1359 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK- 1417
Query: 118 EREKEVVLLR------RSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKC 171
+ E ++V + S A+ + ++ S+ + + + T T+ + +++
Sbjct: 1418 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1477
Query: 172 LDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK---LQEENRLLK-QKVTHVEDLNAKW 227
L + +R ++ ++ E V++ +EK L E + K Q ++L +
Sbjct: 1478 LRRMEEEERLAEQQRAEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1534
Query: 228 QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287
Q R+E Q R +Q +E+ +L + E +I A+ +Q AA R+
Sbjct: 1535 QEEVVRREEAAVDAQQQKRSIQ---------EELQQLRQSSEAEIQ--AKARQAEAAERS 1583
Query: 288 ----ARDAALERVQM--LEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV--- 338
+ + R+Q+ E+Q + + + RA E A+++ ++ +E+ L QV
Sbjct: 1584 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1643
Query: 339 SWRQDSREPD-AGRIHAGSKTA--KYLAADALE 368
S R+ E + A R+ A ++ A K A ALE
Sbjct: 1644 SQRKRQAEVELASRVKAEAEAAREKQRALQALE 1676
Score = 47.0 bits (110), Expect = 3e-05
Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 46/353 (13%)
Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIAR--LRARLAAL-EGDAAPSLVDAL 67
EEA R + A + RLR+L ++ A+ +A L+ ++ A+ E + + L
Sbjct: 2415 EEAARLSVAA-----QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2469
Query: 68 LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124
+Q +EQ RR ++++ E++ ++L E+ + Q+ L Q Q E E
Sbjct: 2470 QQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2520
Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184
L+ +AE RA+A ++ + + ++ L T Q L + QR +
Sbjct: 2521 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSD 2579
Query: 185 RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW--QRYNASRDEYVRGLH 242
D + ++ EKLQ+E +LL+ K ++ + + Q A + ++
Sbjct: 2580 H--DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2637
Query: 243 AQLRGLQIPHEP-----ELMRKEISRLNRQLEEKINDCAEVKQE----LAASRTAR---- 289
+ L+ + + +L + E+++ + EE+ +++QE +A+ AR
Sbjct: 2638 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2697
Query: 290 ------DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
E +Q LEQQ +++ ++E R R Q ++ E E+ A+L H
Sbjct: 2698 EAEEGVRRKQEELQQLEQQ-RRQQEELLAEENQRLREQLQLLE-EQHRAALAH 2748
Score = 46.2 bits (108), Expect = 6e-05
Identities = 98/393 (24%), Positives = 156/393 (39%), Gaps = 42/393 (10%)
Query: 62 SLVDALLEQVARF-REQLRR--QEGGAAEAQMRQEIERLTE--RLEEKEREMQQLLSQPQ 116
S + L Q +F E LRR +E AE Q +E ERL E EK+R++ + +Q +
Sbjct: 1461 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1520
Query: 117 HEREKEVVLLRRSMAEG----ERARAASDVLCRSLANETHQLRRTLTA-------TAHMC 165
+ E+E L++ M E E A + RS+ E QLR++ A A
Sbjct: 1521 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1580
Query: 166 QHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225
+ ++E R E + Q +G +Q++ + +E +Q E L
Sbjct: 1581 ERSRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRR 1638
Query: 226 KWQRYNASRDEYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAA 284
+ Q DE R A++ ++ E E R E R + LEE E ++ L
Sbjct: 1639 QVQ------DESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1691
Query: 285 SRTAR----DAALERVQ-MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339
+ R ALE Q E ++ + + F + A ER+ +QE VA L +
Sbjct: 1692 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAE 1748
Query: 340 WR-QDSREPDAGRIHAGSKTAKY--LAADALELMVPG---GWRPGTGSQQPEPPAEGGHP 393
R Q E + R A + ++ A +AL L + + + E E
Sbjct: 1749 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1808
Query: 394 GAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAE 426
A +RG+ + Q Q EQ E R +AE
Sbjct: 1809 EARRRGKAEEQAVR--QRELAEQELEKQRQLAE 1839
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 60.5 bits (145), Expect = 3e-09
Identities = 84/343 (24%), Positives = 141/343 (41%), Gaps = 50/343 (14%)
Query: 11 EEAPRAAAALCTLYHEAGQRLR----RLQDQLAARDALIARLRARLAALEGDAAPSLVDA 66
E+A AA L E +R R R+Q LAA + + +A L +E + A
Sbjct: 1941 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER------LKA 1994
Query: 67 LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEE---------KEREMQQLLSQPQH 117
+E+ R RE R ++ A + Q+ QE + + EE KE+E+QQ L Q Q
Sbjct: 1995 KVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2052
Query: 118 EREK---EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE 174
++ E RR+ E E AR ++ E Q RR + + Q +
Sbjct: 2053 VLDQLRGEAEAARRAAEEAEEARVQAE-------REAAQSRRQVEEAERLKQSAEEQAQA 2105
Query: 175 RQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLN------AKWQ 228
R AQ E+ ++E Q + Q E L+QK ++ +
Sbjct: 2106 RAQAQA-AAEKLRKEAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2156
Query: 229 RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288
R A ++ + L QL + H+ L+ +E+ RL + E ++V++EL + R
Sbjct: 2157 RQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2214
Query: 289 RD--AALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEE 329
+ + L+ E + L +D ++R +E A+ Q EE
Sbjct: 2215 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2257
Score = 57.8 bits (138), Expect = 2e-08
Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 43/360 (11%)
Query: 29 QRLRRLQDQLAARDALIARLRARLAAL---EGDAAPSLVDALLEQVARFREQLRRQEGGA 85
+ L ++ Q+ L AR+ A AL + D + E++ + E+ R A
Sbjct: 2206 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2265
Query: 86 AEA----QMRQEIERLTERLEEK--EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAA 139
EA Q+ +E L EK + +MQ + + + E E++ ++ +A+ + R
Sbjct: 2266 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2325
Query: 140 SDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG-- 195
D + + LA ET +RTL A Q + E + + V E S Q+ +
Sbjct: 2326 EDKEQMAQQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2382
Query: 196 --HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
+ + EKL ++KVT V+ L + Q Q H+
Sbjct: 2383 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------------QSDHD 2422
Query: 254 PELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR-DAALERVQMLEQQILAYKDDFMS 312
E +R+ I+ L R+ E+ + ++ + +T + + L+ Q L+Q L+ KD +
Sbjct: 2423 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2482
Query: 313 ERADRERAQSRIQELEE----KVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368
E+ ++++++L + K L + +Q E + R+ A + A+ +A E
Sbjct: 2483 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2542
Score = 51.6 bits (122), Expect = 1e-06
Identities = 86/341 (25%), Positives = 138/341 (40%), Gaps = 26/341 (7%)
Query: 26 EAGQRLRR-LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84
E +RLRR +QD+ + L +R+ A E +AA AL + E+LR Q
Sbjct: 1472 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRAL-----QALEELRLQ--- 1522
Query: 85 AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG----ERARAAS 140
A EA+ RL + E+ R++Q L Q E E+ R S AE ER+
Sbjct: 1523 AEEAE-----RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1577
Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV- 199
V L E + R A A + A+ ER + N R Q+E S+
Sbjct: 1578 HVAVAQLREEAER-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1636
Query: 200 QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259
Q+ EK +EE ++ E+ + + E R L ++ E EL+R
Sbjct: 1637 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR- 1695
Query: 260 EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRER 319
L + E+ +++ELA + AA ++ Q LE ++ + + A + R
Sbjct: 1696 ----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1751
Query: 320 AQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360
A+ + EK L + R +A R+ A ++ AK
Sbjct: 1752 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1792
Score = 50.8 bits (120), Expect = 2e-06
Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 32/300 (10%)
Query: 27 AGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAA 86
A ++LR+ +Q AAR R +A AAL A DA +E+ +F EQ RQ+
Sbjct: 2112 AAEKLRKEAEQEAAR-----RAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---- 2159
Query: 87 EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRS 146
AQ+ QE+ L +LEE + + L ++E+ L+ E R R+ + S
Sbjct: 2160 -AQVEQELTTLRLQLEETDHQKNLL--------DEELQRLKAEATEAARQRSQVEEELFS 2210
Query: 147 LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKL 206
+ + +L + ++ A L ++ + QR + E + + + + ++
Sbjct: 2211 VRVQMEELSKLKARIE--AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2268
Query: 207 QEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNR 266
+L ++ + L K + + L A+ LQ + EL +++ RL
Sbjct: 2269 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ--QQKELAQEQARRLQE 2326
Query: 267 QLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326
E+ + Q+LA LE + + ++ A + A+ RAQ+R +E
Sbjct: 2327 DKEQ-------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2379
Score = 50.4 bits (119), Expect = 3e-06
Identities = 84/403 (20%), Positives = 165/403 (40%), Gaps = 32/403 (7%)
Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85
EA +R + + + R+ L + EG A L A +++ R R + ++G
Sbjct: 1650 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAET--EQGEQ 1705
Query: 86 AEAQMRQEIERLTERLEEKEREMQQLLSQPQHER-EKEVVLLRRSMAEGERARAASDVLC 144
+ +E+ RL ++ Q+L ++ R E EV+L ++ AE E +R+ S+
Sbjct: 1706 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE-EESRSTSEKSK 1764
Query: 145 RSLANETHQLR---------RTLTATAHMCQHLAK--CLDERQHAQRNVGERSPDQSEHT 193
+ L E + R R L A + LA+ +R A+R + E+ E T
Sbjct: 1765 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1824
Query: 194 DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
T + +++ + EN L++ ED + +R ++ + +L L+ +
Sbjct: 1825 RLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1881
Query: 254 PELMR-----KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308
EL R ++ R RQ+EE+I ++ AA + + L R++ + L K+
Sbjct: 1882 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1941
Query: 309 DFMSE-------RADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKY 361
E A+ ER + +E +K + + + ++ + + R+ A + A+
Sbjct: 1942 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2001
Query: 362 LAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQ 404
L A + +Q+ E H A Q+ + +LQ
Sbjct: 2002 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2044
Score = 49.3 bits (116), Expect = 7e-06
Identities = 75/329 (22%), Positives = 133/329 (40%), Gaps = 51/329 (15%)
Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ---- 81
EA QR RRL++Q A A I A+L D+ L+E R R Q+ +
Sbjct: 1851 EAFQR-RRLEEQAAQHKADIEERLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILAL 1908
Query: 82 -----EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERA 136
+ A +A++ E+ R+ E+ R +Q E E R+ AE ER
Sbjct: 1909 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA--------ELEAARQRQLAAEEERR 1960
Query: 137 RA-ASDVLCRSLANETHQLRRT---------LTATAHMCQHLAKCLDERQHAQRNVGERS 186
R A + + +SLA E R+ L A + L + ++ Q + + +
Sbjct: 1961 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2020
Query: 187 PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246
+ + +V +K QE + L+Q+ + ++ L + + + +E A+
Sbjct: 2021 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEA 2074
Query: 247 GLQIPHEPELMRKEIS---RLNRQLEEKINDCA-----------EVKQELAASRTARDAA 292
+Q E R+++ RL + EE+ A E +QE A A AA
Sbjct: 2075 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2134
Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQ 321
L + Q + ++ +K +E+ R++AQ
Sbjct: 2135 LRQKQAADAEMEKHKK--FAEQTLRQKAQ 2161
Score = 47.4 bits (111), Expect = 3e-05
Identities = 89/393 (22%), Positives = 165/393 (41%), Gaps = 72/393 (18%)
Query: 33 RLQDQLAARDALIARLRARLAAL---------EGDAAPSLVDALLEQVARFREQL----- 78
RLQ + RD + R R R+A L + D ++ L Q+ +RE
Sbjct: 1140 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1199
Query: 79 ------RRQE---------GGAAEAQMRQE------IERLTERLEEKEREMQQLLSQPQH 117
RRQE A Q+RQE IER E++EE +R +Q ++ +
Sbjct: 1200 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK- 1258
Query: 118 EREKEVVLLR------RSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKC 171
+ E ++V + S A+ + ++ S+ + + + T T+ + +++
Sbjct: 1259 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1318
Query: 172 LDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK---LQEENRLLK-QKVTHVEDLNAKW 227
L + +R ++ ++ E V++ +EK L E + K Q ++L +
Sbjct: 1319 LRRMEEEERLAEQQRAEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1375
Query: 228 QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287
Q R+E Q R +Q +E+ +L + E +I A+ +Q AA R+
Sbjct: 1376 QEEVVRREEAAVDAQQQKRSIQ---------EELQQLRQSSEAEIQ--AKARQAEAAERS 1424
Query: 288 ----ARDAALERVQM--LEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV--- 338
+ + R+Q+ E+Q + + + RA E A+++ ++ +E+ L QV
Sbjct: 1425 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1484
Query: 339 SWRQDSREPD-AGRIHAGSKTA--KYLAADALE 368
S R+ E + A R+ A ++ A K A ALE
Sbjct: 1485 SQRKRQAEVELASRVKAEAEAAREKQRALQALE 1517
Score = 47.0 bits (110), Expect = 3e-05
Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 46/353 (13%)
Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIAR--LRARLAAL-EGDAAPSLVDAL 67
EEA R + A + RLR+L ++ A+ +A L+ ++ A+ E + + L
Sbjct: 2256 EEAARLSVAA-----QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2310
Query: 68 LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124
+Q +EQ RR ++++ E++ ++L E+ + Q+ L Q Q E E
Sbjct: 2311 QQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2361
Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184
L+ +AE RA+A ++ + + ++ L T Q L + QR +
Sbjct: 2362 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSD 2420
Query: 185 RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW--QRYNASRDEYVRGLH 242
D + ++ EKLQ+E +LL+ K ++ + + Q A + ++
Sbjct: 2421 H--DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2478
Query: 243 AQLRGLQIPHEP-----ELMRKEISRLNRQLEEKINDCAEVKQE----LAASRTAR---- 289
+ L+ + + +L + E+++ + EE+ +++QE +A+ AR
Sbjct: 2479 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2538
Query: 290 ------DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
E +Q LEQQ +++ ++E R R Q ++ E E+ A+L H
Sbjct: 2539 EAEEGVRRKQEELQQLEQQ-RRQQEELLAEENQRLREQLQLLE-EQHRAALAH 2589
Score = 46.2 bits (108), Expect = 6e-05
Identities = 98/393 (24%), Positives = 156/393 (39%), Gaps = 42/393 (10%)
Query: 62 SLVDALLEQVARF-REQLRR--QEGGAAEAQMRQEIERLTE--RLEEKEREMQQLLSQPQ 116
S + L Q +F E LRR +E AE Q +E ERL E EK+R++ + +Q +
Sbjct: 1302 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1361
Query: 117 HEREKEVVLLRRSMAEG----ERARAASDVLCRSLANETHQLRRTLTA-------TAHMC 165
+ E+E L++ M E E A + RS+ E QLR++ A A
Sbjct: 1362 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1421
Query: 166 QHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225
+ ++E R E + Q +G +Q++ + +E +Q E L
Sbjct: 1422 ERSRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRR 1479
Query: 226 KWQRYNASRDEYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAA 284
+ Q DE R A++ ++ E E R E R + LEE E ++ L
Sbjct: 1480 QVQ------DESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1532
Query: 285 SRTAR----DAALERVQ-MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339
+ R ALE Q E ++ + + F + A ER+ +QE VA L +
Sbjct: 1533 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAE 1589
Query: 340 WR-QDSREPDAGRIHAGSKTAKY--LAADALELMVPG---GWRPGTGSQQPEPPAEGGHP 393
R Q E + R A + ++ A +AL L + + + E E
Sbjct: 1590 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1649
Query: 394 GAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAE 426
A +RG+ + Q Q EQ E R +AE
Sbjct: 1650 EARRRGKAEEQAVR--QRELAEQELEKQRQLAE 1680
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 60.5 bits (145), Expect = 3e-09
Identities = 84/343 (24%), Positives = 141/343 (41%), Gaps = 50/343 (14%)
Query: 11 EEAPRAAAALCTLYHEAGQRLR----RLQDQLAARDALIARLRARLAALEGDAAPSLVDA 66
E+A AA L E +R R R+Q LAA + + +A L +E + A
Sbjct: 1949 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER------LKA 2002
Query: 67 LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEE---------KEREMQQLLSQPQH 117
+E+ R RE R ++ A + Q+ QE + + EE KE+E+QQ L Q Q
Sbjct: 2003 KVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2060
Query: 118 EREK---EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE 174
++ E RR+ E E AR ++ E Q RR + + Q +
Sbjct: 2061 VLDQLRGEAEAARRAAEEAEEARVQAE-------REAAQSRRQVEEAERLKQSAEEQAQA 2113
Query: 175 RQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLN------AKWQ 228
R AQ E+ ++E Q + Q E L+QK ++ +
Sbjct: 2114 RAQAQA-AAEKLRKEAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2164
Query: 229 RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288
R A ++ + L QL + H+ L+ +E+ RL + E ++V++EL + R
Sbjct: 2165 RQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2222
Query: 289 RD--AALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEE 329
+ + L+ E + L +D ++R +E A+ Q EE
Sbjct: 2223 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2265
Score = 57.8 bits (138), Expect = 2e-08
Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 43/360 (11%)
Query: 29 QRLRRLQDQLAARDALIARLRARLAAL---EGDAAPSLVDALLEQVARFREQLRRQEGGA 85
+ L ++ Q+ L AR+ A AL + D + E++ + E+ R A
Sbjct: 2214 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2273
Query: 86 AEA----QMRQEIERLTERLEEK--EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAA 139
EA Q+ +E L EK + +MQ + + + E E++ ++ +A+ + R
Sbjct: 2274 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2333
Query: 140 SDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG-- 195
D + + LA ET +RTL A Q + E + + V E S Q+ +
Sbjct: 2334 EDKEQMAQQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2390
Query: 196 --HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
+ + EKL ++KVT V+ L + Q Q H+
Sbjct: 2391 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------------QSDHD 2430
Query: 254 PELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR-DAALERVQMLEQQILAYKDDFMS 312
E +R+ I+ L R+ E+ + ++ + +T + + L+ Q L+Q L+ KD +
Sbjct: 2431 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2490
Query: 313 ERADRERAQSRIQELEE----KVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368
E+ ++++++L + K L + +Q E + R+ A + A+ +A E
Sbjct: 2491 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2550
Score = 51.6 bits (122), Expect = 1e-06
Identities = 86/341 (25%), Positives = 138/341 (40%), Gaps = 26/341 (7%)
Query: 26 EAGQRLRR-LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84
E +RLRR +QD+ + L +R+ A E +AA AL + E+LR Q
Sbjct: 1480 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRAL-----QALEELRLQ--- 1530
Query: 85 AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG----ERARAAS 140
A EA+ RL + E+ R++Q L Q E E+ R S AE ER+
Sbjct: 1531 AEEAE-----RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1585
Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV- 199
V L E + R A A + A+ ER + N R Q+E S+
Sbjct: 1586 HVAVAQLREEAER-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1644
Query: 200 QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259
Q+ EK +EE ++ E+ + + E R L ++ E EL+R
Sbjct: 1645 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR- 1703
Query: 260 EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRER 319
L + E+ +++ELA + AA ++ Q LE ++ + + A + R
Sbjct: 1704 ----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1759
Query: 320 AQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360
A+ + EK L + R +A R+ A ++ AK
Sbjct: 1760 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1800
Score = 50.8 bits (120), Expect = 2e-06
Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 32/300 (10%)
Query: 27 AGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAA 86
A ++LR+ +Q AAR R +A AAL A DA +E+ +F EQ RQ+
Sbjct: 2120 AAEKLRKEAEQEAAR-----RAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---- 2167
Query: 87 EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRS 146
AQ+ QE+ L +LEE + + L ++E+ L+ E R R+ + S
Sbjct: 2168 -AQVEQELTTLRLQLEETDHQKNLL--------DEELQRLKAEATEAARQRSQVEEELFS 2218
Query: 147 LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKL 206
+ + +L + ++ A L ++ + QR + E + + + + ++
Sbjct: 2219 VRVQMEELSKLKARIE--AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2276
Query: 207 QEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNR 266
+L ++ + L K + + L A+ LQ + EL +++ RL
Sbjct: 2277 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ--QQKELAQEQARRLQE 2334
Query: 267 QLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326
E+ + Q+LA LE + + ++ A + A+ RAQ+R +E
Sbjct: 2335 DKEQ-------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2387
Score = 50.4 bits (119), Expect = 3e-06
Identities = 84/403 (20%), Positives = 165/403 (40%), Gaps = 32/403 (7%)
Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85
EA +R + + + R+ L + EG A L A +++ R R + ++G
Sbjct: 1658 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAET--EQGEQ 1713
Query: 86 AEAQMRQEIERLTERLEEKEREMQQLLSQPQHER-EKEVVLLRRSMAEGERARAASDVLC 144
+ +E+ RL ++ Q+L ++ R E EV+L ++ AE E +R+ S+
Sbjct: 1714 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE-EESRSTSEKSK 1772
Query: 145 RSLANETHQLR---------RTLTATAHMCQHLAK--CLDERQHAQRNVGERSPDQSEHT 193
+ L E + R R L A + LA+ +R A+R + E+ E T
Sbjct: 1773 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1832
Query: 194 DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
T + +++ + EN L++ ED + +R ++ + +L L+ +
Sbjct: 1833 RLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1889
Query: 254 PELMR-----KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308
EL R ++ R RQ+EE+I ++ AA + + L R++ + L K+
Sbjct: 1890 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1949
Query: 309 DFMSE-------RADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKY 361
E A+ ER + +E +K + + + ++ + + R+ A + A+
Sbjct: 1950 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2009
Query: 362 LAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQ 404
L A + +Q+ E H A Q+ + +LQ
Sbjct: 2010 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2052
Score = 49.3 bits (116), Expect = 7e-06
Identities = 75/329 (22%), Positives = 133/329 (40%), Gaps = 51/329 (15%)
Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ---- 81
EA QR RRL++Q A A I A+L D+ L+E R R Q+ +
Sbjct: 1859 EAFQR-RRLEEQAAQHKADIEERLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILAL 1916
Query: 82 -----EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERA 136
+ A +A++ E+ R+ E+ R +Q E E R+ AE ER
Sbjct: 1917 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA--------ELEAARQRQLAAEEERR 1968
Query: 137 RA-ASDVLCRSLANETHQLRRT---------LTATAHMCQHLAKCLDERQHAQRNVGERS 186
R A + + +SLA E R+ L A + L + ++ Q + + +
Sbjct: 1969 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2028
Query: 187 PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246
+ + +V +K QE + L+Q+ + ++ L + + + +E A+
Sbjct: 2029 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEA 2082
Query: 247 GLQIPHEPELMRKEIS---RLNRQLEEKINDCA-----------EVKQELAASRTARDAA 292
+Q E R+++ RL + EE+ A E +QE A A AA
Sbjct: 2083 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2142
Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQ 321
L + Q + ++ +K +E+ R++AQ
Sbjct: 2143 LRQKQAADAEMEKHKK--FAEQTLRQKAQ 2169
Score = 47.4 bits (111), Expect = 3e-05
Identities = 89/393 (22%), Positives = 165/393 (41%), Gaps = 72/393 (18%)
Query: 33 RLQDQLAARDALIARLRARLAAL---------EGDAAPSLVDALLEQVARFREQL----- 78
RLQ + RD + R R R+A L + D ++ L Q+ +RE
Sbjct: 1148 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1207
Query: 79 ------RRQE---------GGAAEAQMRQE------IERLTERLEEKEREMQQLLSQPQH 117
RRQE A Q+RQE IER E++EE +R +Q ++ +
Sbjct: 1208 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK- 1266
Query: 118 EREKEVVLLR------RSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKC 171
+ E ++V + S A+ + ++ S+ + + + T T+ + +++
Sbjct: 1267 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1326
Query: 172 LDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK---LQEENRLLK-QKVTHVEDLNAKW 227
L + +R ++ ++ E V++ +EK L E + K Q ++L +
Sbjct: 1327 LRRMEEEERLAEQQRAEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1383
Query: 228 QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287
Q R+E Q R +Q +E+ +L + E +I A+ +Q AA R+
Sbjct: 1384 QEEVVRREEAAVDAQQQKRSIQ---------EELQQLRQSSEAEIQ--AKARQAEAAERS 1432
Query: 288 ----ARDAALERVQM--LEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV--- 338
+ + R+Q+ E+Q + + + RA E A+++ ++ +E+ L QV
Sbjct: 1433 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1492
Query: 339 SWRQDSREPD-AGRIHAGSKTA--KYLAADALE 368
S R+ E + A R+ A ++ A K A ALE
Sbjct: 1493 SQRKRQAEVELASRVKAEAEAAREKQRALQALE 1525
Score = 47.0 bits (110), Expect = 3e-05
Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 46/353 (13%)
Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIAR--LRARLAAL-EGDAAPSLVDAL 67
EEA R + A + RLR+L ++ A+ +A L+ ++ A+ E + + L
Sbjct: 2264 EEAARLSVAA-----QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2318
Query: 68 LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124
+Q +EQ RR ++++ E++ ++L E+ + Q+ L Q Q E E
Sbjct: 2319 QQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2369
Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184
L+ +AE RA+A ++ + + ++ L T Q L + QR +
Sbjct: 2370 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSD 2428
Query: 185 RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW--QRYNASRDEYVRGLH 242
D + ++ EKLQ+E +LL+ K ++ + + Q A + ++
Sbjct: 2429 H--DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2486
Query: 243 AQLRGLQIPHEP-----ELMRKEISRLNRQLEEKINDCAEVKQE----LAASRTAR---- 289
+ L+ + + +L + E+++ + EE+ +++QE +A+ AR
Sbjct: 2487 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2546
Query: 290 ------DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
E +Q LEQQ +++ ++E R R Q ++ E E+ A+L H
Sbjct: 2547 EAEEGVRRKQEELQQLEQQ-RRQQEELLAEENQRLREQLQLLE-EQHRAALAH 2597
Score = 46.2 bits (108), Expect = 6e-05
Identities = 98/393 (24%), Positives = 156/393 (39%), Gaps = 42/393 (10%)
Query: 62 SLVDALLEQVARF-REQLRR--QEGGAAEAQMRQEIERLTE--RLEEKEREMQQLLSQPQ 116
S + L Q +F E LRR +E AE Q +E ERL E EK+R++ + +Q +
Sbjct: 1310 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1369
Query: 117 HEREKEVVLLRRSMAEG----ERARAASDVLCRSLANETHQLRRTLTA-------TAHMC 165
+ E+E L++ M E E A + RS+ E QLR++ A A
Sbjct: 1370 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1429
Query: 166 QHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225
+ ++E R E + Q +G +Q++ + +E +Q E L
Sbjct: 1430 ERSRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRR 1487
Query: 226 KWQRYNASRDEYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAA 284
+ Q DE R A++ ++ E E R E R + LEE E ++ L
Sbjct: 1488 QVQ------DESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1540
Query: 285 SRTAR----DAALERVQ-MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339
+ R ALE Q E ++ + + F + A ER+ +QE VA L +
Sbjct: 1541 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAE 1597
Query: 340 WR-QDSREPDAGRIHAGSKTAKY--LAADALELMVPG---GWRPGTGSQQPEPPAEGGHP 393
R Q E + R A + ++ A +AL L + + + E E
Sbjct: 1598 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1657
Query: 394 GAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAE 426
A +RG+ + Q Q EQ E R +AE
Sbjct: 1658 EARRRGKAEEQAVR--QRELAEQELEKQRQLAE 1688
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 60.5 bits (145), Expect = 3e-09
Identities = 84/343 (24%), Positives = 141/343 (41%), Gaps = 50/343 (14%)
Query: 11 EEAPRAAAALCTLYHEAGQRLR----RLQDQLAARDALIARLRARLAALEGDAAPSLVDA 66
E+A AA L E +R R R+Q LAA + + +A L +E + A
Sbjct: 1990 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER------LKA 2043
Query: 67 LLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEE---------KEREMQQLLSQPQH 117
+E+ R RE R ++ A + Q+ QE + + EE KE+E+QQ L Q Q
Sbjct: 2044 KVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2101
Query: 118 EREK---EVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE 174
++ E RR+ E E AR ++ E Q RR + + Q +
Sbjct: 2102 VLDQLRGEAEAARRAAEEAEEARVQAE-------REAAQSRRQVEEAERLKQSAEEQAQA 2154
Query: 175 RQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLN------AKWQ 228
R AQ E+ ++E Q + Q E L+QK ++ +
Sbjct: 2155 RAQAQA-AAEKLRKEAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2205
Query: 229 RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288
R A ++ + L QL + H+ L+ +E+ RL + E ++V++EL + R
Sbjct: 2206 RQKAQVEQELTTLRLQLE--ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2263
Query: 289 RD--AALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEE 329
+ + L+ E + L +D ++R +E A+ Q EE
Sbjct: 2264 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2306
Score = 57.8 bits (138), Expect = 2e-08
Identities = 77/360 (21%), Positives = 148/360 (41%), Gaps = 43/360 (11%)
Query: 29 QRLRRLQDQLAARDALIARLRARLAAL---EGDAAPSLVDALLEQVARFREQLRRQEGGA 85
+ L ++ Q+ L AR+ A AL + D + E++ + E+ R A
Sbjct: 2255 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2314
Query: 86 AEA----QMRQEIERLTERLEEK--EREMQQLLSQPQHEREKEVVLLRRSMAEGERARAA 139
EA Q+ +E L EK + +MQ + + + E E++ ++ +A+ + R
Sbjct: 2315 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2374
Query: 140 SDV--LCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG-- 195
D + + LA ET +RTL A Q + E + + V E S Q+ +
Sbjct: 2375 EDKEQMAQQLAEETQGFQRTLEAER---QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2431
Query: 196 --HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
+ + EKL ++KVT V+ L + Q Q H+
Sbjct: 2432 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ--------------------QSDHD 2471
Query: 254 PELMRKEISRLNRQLEEKINDCAEVKQELAASRTAR-DAALERVQMLEQQILAYKDDFMS 312
E +R+ I+ L R+ E+ + ++ + +T + + L+ Q L+Q L+ KD +
Sbjct: 2472 AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2531
Query: 313 ERADRERAQSRIQELEE----KVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALE 368
E+ ++++++L + K L + +Q E + R+ A + A+ +A E
Sbjct: 2532 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2591
Score = 51.6 bits (122), Expect = 1e-06
Identities = 86/341 (25%), Positives = 138/341 (40%), Gaps = 26/341 (7%)
Query: 26 EAGQRLRR-LQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84
E +RLRR +QD+ + L +R+ A E +AA AL + E+LR Q
Sbjct: 1521 EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAAREKQRAL-----QALEELRLQ--- 1571
Query: 85 AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEG----ERARAAS 140
A EA+ RL + E+ R++Q L Q E E+ R S AE ER+
Sbjct: 1572 AEEAE-----RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1626
Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV- 199
V L E + R A A + A+ ER + N R Q+E S+
Sbjct: 1627 HVAVAQLREEAER-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1685
Query: 200 QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259
Q+ EK +EE ++ E+ + + E R L ++ E EL+R
Sbjct: 1686 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR- 1744
Query: 260 EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRER 319
L + E+ +++ELA + AA ++ Q LE ++ + + A + R
Sbjct: 1745 ----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1800
Query: 320 AQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAK 360
A+ + EK L + R +A R+ A ++ AK
Sbjct: 1801 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1841
Score = 50.8 bits (120), Expect = 2e-06
Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 32/300 (10%)
Query: 27 AGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAA 86
A ++LR+ +Q AAR R +A AAL A DA +E+ +F EQ RQ+
Sbjct: 2161 AAEKLRKEAEQEAAR-----RAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---- 2208
Query: 87 EAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRS 146
AQ+ QE+ L +LEE + + L ++E+ L+ E R R+ + S
Sbjct: 2209 -AQVEQELTTLRLQLEETDHQKNLL--------DEELQRLKAEATEAARQRSQVEEELFS 2259
Query: 147 LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKL 206
+ + +L + ++ A L ++ + QR + E + + + + ++
Sbjct: 2260 VRVQMEELSKLKARIE--AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2317
Query: 207 QEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNR 266
+L ++ + L K + + L A+ LQ + EL +++ RL
Sbjct: 2318 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ--QQKELAQEQARRLQE 2375
Query: 267 QLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326
E+ + Q+LA LE + + ++ A + A+ RAQ+R +E
Sbjct: 2376 DKEQ-------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2428
Score = 50.4 bits (119), Expect = 3e-06
Identities = 84/403 (20%), Positives = 165/403 (40%), Gaps = 32/403 (7%)
Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGA 85
EA +R + + + R+ L + EG A L A +++ R R + ++G
Sbjct: 1699 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAET--EQGEQ 1754
Query: 86 AEAQMRQEIERLTERLEEKEREMQQLLSQPQHER-EKEVVLLRRSMAEGERARAASDVLC 144
+ +E+ RL ++ Q+L ++ R E EV+L ++ AE E +R+ S+
Sbjct: 1755 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE-EESRSTSEKSK 1813
Query: 145 RSLANETHQLR---------RTLTATAHMCQHLAK--CLDERQHAQRNVGERSPDQSEHT 193
+ L E + R R L A + LA+ +R A+R + E+ E T
Sbjct: 1814 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1873
Query: 194 DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHE 253
T + +++ + EN L++ ED + +R ++ + +L L+ +
Sbjct: 1874 RLKTEAEIALKEKEAENERLRRL---AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1930
Query: 254 PELMR-----KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKD 308
EL R ++ R RQ+EE+I ++ AA + + L R++ + L K+
Sbjct: 1931 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1990
Query: 309 DFMSE-------RADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKY 361
E A+ ER + +E +K + + + ++ + + R+ A + A+
Sbjct: 1991 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2050
Query: 362 LAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQ 404
L A + +Q+ E H A Q+ + +LQ
Sbjct: 2051 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2093
Score = 49.3 bits (116), Expect = 7e-06
Identities = 75/329 (22%), Positives = 133/329 (40%), Gaps = 51/329 (15%)
Query: 26 EAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQ---- 81
EA QR RRL++Q A A I A+L D+ L+E R R Q+ +
Sbjct: 1900 EAFQR-RRLEEQAAQHKADIEERLAQLRKAS-DSELERQKGLVEDTLRQRRQVEEEILAL 1957
Query: 82 -----EGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERA 136
+ A +A++ E+ R+ E+ R +Q E E R+ AE ER
Sbjct: 1958 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA--------ELEAARQRQLAAEEERR 2009
Query: 137 RA-ASDVLCRSLANETHQLRRT---------LTATAHMCQHLAKCLDERQHAQRNVGERS 186
R A + + +SLA E R+ L A + L + ++ Q + + +
Sbjct: 2010 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2069
Query: 187 PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246
+ + +V +K QE + L+Q+ + ++ L + + + +E A+
Sbjct: 2070 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE------AEEA 2123
Query: 247 GLQIPHEPELMRKEIS---RLNRQLEEKINDCA-----------EVKQELAASRTARDAA 292
+Q E R+++ RL + EE+ A E +QE A A AA
Sbjct: 2124 RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA 2183
Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQ 321
L + Q + ++ +K +E+ R++AQ
Sbjct: 2184 LRQKQAADAEMEKHKK--FAEQTLRQKAQ 2210
Score = 47.4 bits (111), Expect = 3e-05
Identities = 89/393 (22%), Positives = 165/393 (41%), Gaps = 72/393 (18%)
Query: 33 RLQDQLAARDALIARLRARLAAL---------EGDAAPSLVDALLEQVARFREQL----- 78
RLQ + RD + R R R+A L + D ++ L Q+ +RE
Sbjct: 1189 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1248
Query: 79 ------RRQE---------GGAAEAQMRQE------IERLTERLEEKEREMQQLLSQPQH 117
RRQE A Q+RQE IER E++EE +R +Q ++ +
Sbjct: 1249 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK- 1307
Query: 118 EREKEVVLLR------RSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKC 171
+ E ++V + S A+ + ++ S+ + + + T T+ + +++
Sbjct: 1308 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1367
Query: 172 LDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK---LQEENRLLK-QKVTHVEDLNAKW 227
L + +R ++ ++ E V++ +EK L E + K Q ++L +
Sbjct: 1368 LRRMEEEERLAEQQRAEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1424
Query: 228 QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287
Q R+E Q R +Q +E+ +L + E +I A+ +Q AA R+
Sbjct: 1425 QEEVVRREEAAVDAQQQKRSIQ---------EELQQLRQSSEAEIQ--AKARQAEAAERS 1473
Query: 288 ----ARDAALERVQM--LEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQV--- 338
+ + R+Q+ E+Q + + + RA E A+++ ++ +E+ L QV
Sbjct: 1474 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1533
Query: 339 SWRQDSREPD-AGRIHAGSKTA--KYLAADALE 368
S R+ E + A R+ A ++ A K A ALE
Sbjct: 1534 SQRKRQAEVELASRVKAEAEAAREKQRALQALE 1566
Score = 47.0 bits (110), Expect = 3e-05
Identities = 77/353 (21%), Positives = 153/353 (43%), Gaps = 46/353 (13%)
Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIAR--LRARLAAL-EGDAAPSLVDAL 67
EEA R + A + RLR+L ++ A+ +A L+ ++ A+ E + + L
Sbjct: 2305 EEAARLSVAA-----QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2359
Query: 68 LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLS---QPQHEREKEVV 124
+Q +EQ RR ++++ E++ ++L E+ + Q+ L Q Q E E
Sbjct: 2360 QQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2410
Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184
L+ +AE RA+A ++ + + ++ L T Q L + QR +
Sbjct: 2411 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSD 2469
Query: 185 RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW--QRYNASRDEYVRGLH 242
D + ++ EKLQ+E +LL+ K ++ + + Q A + ++
Sbjct: 2470 H--DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2527
Query: 243 AQLRGLQIPHEP-----ELMRKEISRLNRQLEEKINDCAEVKQE----LAASRTAR---- 289
+ L+ + + +L + E+++ + EE+ +++QE +A+ AR
Sbjct: 2528 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2587
Query: 290 ------DAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
E +Q LEQQ +++ ++E R R Q ++ E E+ A+L H
Sbjct: 2588 EAEEGVRRKQEELQQLEQQ-RRQQEELLAEENQRLREQLQLLE-EQHRAALAH 2638
Score = 46.2 bits (108), Expect = 6e-05
Identities = 98/393 (24%), Positives = 156/393 (39%), Gaps = 42/393 (10%)
Query: 62 SLVDALLEQVARF-REQLRR--QEGGAAEAQMRQEIERLTE--RLEEKEREMQQLLSQPQ 116
S + L Q +F E LRR +E AE Q +E ERL E EK+R++ + +Q +
Sbjct: 1351 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1410
Query: 117 HEREKEVVLLRRSMAEG----ERARAASDVLCRSLANETHQLRRTLTA-------TAHMC 165
+ E+E L++ M E E A + RS+ E QLR++ A A
Sbjct: 1411 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1470
Query: 166 QHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225
+ ++E R E + Q +G +Q++ + +E +Q E L
Sbjct: 1471 ERSRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRR 1528
Query: 226 KWQRYNASRDEYVRGLHAQLR-GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAA 284
+ Q DE R A++ ++ E E R E R + LEE E ++ L
Sbjct: 1529 QVQ------DESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1581
Query: 285 SRTAR----DAALERVQ-MLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339
+ R ALE Q E ++ + + F + A ER+ +QE VA L +
Sbjct: 1582 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS---LQEEHVAVAQLREEAE 1638
Query: 340 WR-QDSREPDAGRIHAGSKTAKY--LAADALELMVPG---GWRPGTGSQQPEPPAEGGHP 393
R Q E + R A + ++ A +AL L + + + E E
Sbjct: 1639 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1698
Query: 394 GAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAE 426
A +RG+ + Q Q EQ E R +AE
Sbjct: 1699 EARRRGKAEEQAVR--QRELAEQELEKQRQLAE 1729
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 60.1 bits (144), Expect = 4e-09
Identities = 67/280 (23%), Positives = 120/280 (42%), Gaps = 25/280 (8%)
Query: 75 REQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGE 134
R++ +E G Q RQE ER EE+ + ++L + + R++E+ R+ E E
Sbjct: 125 RDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQERE 184
Query: 135 RARAASDVLCRSLANET------HQLRRTLTATAHMCQHLAKCLDERQHAQRNVGER--- 185
RA + L +ET QLRR + + K +E+Q +R +R
Sbjct: 185 ERRAEEEQLQSCKGHETEEFPDEEQLRR-----RELLELRRKGREEKQQQRRERQDRVFQ 239
Query: 186 SPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQL 245
++ E T ++ EKLQEE ++++ E+ K +R R+ Q
Sbjct: 240 EEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQ- 298
Query: 246 RGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILA 305
++ E +L RK+ Q EE+ + ++E R + E+ + EQQ+
Sbjct: 299 ---RLRREQQLRRKQEEERREQQEERREQ--QERREQQEERREQQLRREQEERREQQLRR 353
Query: 306 YKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSR 345
+++ ER RE+ R QE E + L + R++ +
Sbjct: 354 EQEE---ER--REQQLRREQEEERREQQLRREQQLRREQQ 388
Score = 54.7 bits (130), Expect = 2e-07
Identities = 75/306 (24%), Positives = 129/306 (42%), Gaps = 39/306 (12%)
Query: 69 EQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHER--------- 119
E+V + EQL R+E E + RQE+ER EE ++E +QLL + Q +R
Sbjct: 1144 EEVQQEEEQLLREE---PEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYR 1200
Query: 120 -EKEVVLLRRSMA--------------EGERARAASD--VLCRSLANET-HQLRRTLTAT 161
E+E+ +R E E+ A D V C+ NE QL +
Sbjct: 1201 EEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRD 1260
Query: 162 AHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEK-LQEENRLLKQKVTHV 220
Q L L E+Q R E+ + + D H + +E+ Q+E + +K
Sbjct: 1261 RQSQQDLQHLLGEQQERDR---EQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEE 1317
Query: 221 EDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQ 280
+ L + + R E R + + LQ E L R+E R R EE++ + ++
Sbjct: 1318 KQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFR--EEELRHQEQGRK 1375
Query: 281 ELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSW 340
L + R ER + E+Q L ++ R DR+R + +E E++++ +
Sbjct: 1376 FLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDR---KFREEEQQLSRQERDRKF 1432
Query: 341 RQDSRE 346
R++ ++
Sbjct: 1433 REEEQQ 1438
Score = 53.9 bits (128), Expect = 3e-07
Identities = 79/293 (26%), Positives = 129/293 (44%), Gaps = 45/293 (15%)
Query: 68 LEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKE---VV 124
LE+ R +Q RR++ E + R+E +RL +R EE+ER Q+L S+ Q RE+E
Sbjct: 491 LEEEERREQQERREQQLRREQEERRE-QRL-KRQEEEERLQQRLRSEQQLRREQEERREQ 548
Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDER--QHAQRNV 182
LL+R E R + + L E + R L K +ER Q +R
Sbjct: 549 LLKRE----EEKRLEQERREQRLKREQEERR----------DQLLKREEERRQQRLKREQ 594
Query: 183 GERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLH 242
ER + + + +E+L++E R +Q++ E + Q+ S ++ R
Sbjct: 595 EERLEQRLKREE--------VERLEQEER-REQRLKREEPEEERRQQLLKSEEQEERRQQ 645
Query: 243 AQLRGLQIPHEPELMRKE-----ISRLNRQLEE--KINDCAEVKQELAASRTARDAALER 295
R Q E L R+E RL R+ EE + + AE +QE AR+ R
Sbjct: 646 QLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE-----QARERIKSR 700
Query: 296 VQMLEQQILAYKDDFMSE---RADRERAQSRIQELEEKVASLLHQVSWRQDSR 345
+ + Q+ + D S+ R ++ Q R QE EEK ++ W+++ R
Sbjct: 701 IPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEER 753
Score = 52.8 bits (125), Expect = 6e-07
Identities = 74/312 (23%), Positives = 129/312 (41%), Gaps = 54/312 (17%)
Query: 69 EQVARFREQLRR---------------------QEGGAAEAQMRQEIERLTE----RLEE 103
+Q R +QLRR Q+ E Q+R+E E E R +E
Sbjct: 297 QQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQE 356
Query: 104 KEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAH 163
+ER QQL + + ER ++ + + + ++ R + QLRR
Sbjct: 357 EERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 416
Query: 164 MC----QHLAKCLDERQHAQRNVGER-----SPDQSEHTDGHTSVQSVIEKLQEENRLLK 214
Q L + +E +H Q++ ER +Q E D + E+ ++E R +
Sbjct: 417 QQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRD-WLKREEETERHEQERRKQQ 475
Query: 215 QKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKIND 274
K E+ +W + +E R + R Q+ E E R++ RL RQ EE+
Sbjct: 476 LKRDQEEERRERWLKL----EEEERREQQERREQQLRREQEERREQ--RLKRQEEEE--- 526
Query: 275 CAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRI-QELEEKVAS 333
++Q L + + R ER +Q+L +++ +R ++ER + R+ +E EE+
Sbjct: 527 --RLQQRLRSEQQLRREQEER----REQLLKREEE---KRLEQERREQRLKREQEERRDQ 577
Query: 334 LLHQVSWRQDSR 345
LL + R+ R
Sbjct: 578 LLKREEERRQQR 589
Score = 51.2 bits (121), Expect = 2e-06
Identities = 76/341 (22%), Positives = 138/341 (40%), Gaps = 34/341 (9%)
Query: 29 QRLRRLQDQLAARDALIARLRARLAA-LEGDAAPSLVDALL-EQVARFREQLRRQEGGAA 86
QRL+R Q++ RD L+ R R L+ + L L E+V R ++ RR++
Sbjct: 565 QRLKREQEE--RRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKR 622
Query: 87 EAQMRQEIERLTERLEEKEREMQQLLSQPQHER-------EKEVVLLRRSMAEGERARAA 139
E + ++L + E++ER QQL + Q R E+E L +R E E R
Sbjct: 623 EEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERRE 682
Query: 140 SDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSV 199
++ +++ + + A + +++ E + E +
Sbjct: 683 QELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRR 742
Query: 200 QSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRK 259
+S ++ QEE R +Q+ + + WQ + E R + L+ E +L +
Sbjct: 743 ESELQ-WQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAE 801
Query: 260 EISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQ-------QILAYKDDFMS 312
E +Q E++ E K++ R R+ L+ ++ EQ Q L ++D +
Sbjct: 802 E----RQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQ 857
Query: 313 ERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIH 353
E D+ER +S+ Q ++K WR E R H
Sbjct: 858 E--DQERRRSQEQRRDQK---------WRWQLEEERKRRRH 887
Score = 50.4 bits (119), Expect = 3e-06
Identities = 64/281 (22%), Positives = 115/281 (40%), Gaps = 46/281 (16%)
Query: 69 EQVARFREQLRRQEGGAAEAQMRQE----IERLTERLEEKEREMQQLLSQPQHEREKEVV 124
EQ R +QLRR++ E Q+R+E E+ R ++ RE ++ + +HE+E+
Sbjct: 386 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQ 445
Query: 125 LLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGE 184
L+R E D L R E H+ R + L Q +R
Sbjct: 446 RLKREQEE------RRDWLKREEETERHEQERR-----------KQQLKRDQEEERRERW 488
Query: 185 RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQ 244
++ E + + + + QEE R +Q++ E+ QR + + Q
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERR--EQRLKRQEEEERLQQRLRSEQ---------Q 537
Query: 245 LRGLQIPHEPELMRKE----------ISRLNRQLEEKINDCAEVKQELAASRTARDAALE 294
LR Q +L+++E RL R+ EE+ + + ++E R R E
Sbjct: 538 LRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKR----E 593
Query: 295 RVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLL 335
+ + LEQ++ + + + + RE+ R + EE+ LL
Sbjct: 594 QEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLL 634
Score = 49.7 bits (117), Expect = 5e-06
Identities = 53/256 (20%), Positives = 110/256 (42%), Gaps = 24/256 (9%)
Query: 76 EQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGER 135
E+ RR+ A+ +++++ + + L+E+E E+Q+ + + +E+E R E E+
Sbjct: 881 ERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQE-----RQYREEEQ 935
Query: 136 ARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDG 195
+ + L R + + R + K +Q ++ +GE P++ +
Sbjct: 936 LQQEEEQLLREEREKRRRQERE--------RQYRKDKKLQQKEEQLLGE-EPEKRRRQER 986
Query: 196 HTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPE 255
+ E QEE +LL+++ + +W+R +DE + LR E
Sbjct: 987 EKKYREEEELQQEEEQLLREE--REKRRRQEWERQYRKKDELQQEEEQLLR-------EE 1037
Query: 256 LMRKEISRLNRQLEEKINDCAEVKQELAASR-TARDAALERVQMLEQQILAYKDDFMSER 314
++ + RQ E+ E +Q L R T R LER E+++ ++ + E
Sbjct: 1038 REKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREE 1097
Query: 315 ADRERAQSRIQELEEK 330
++ R Q R ++ E+
Sbjct: 1098 PEKRRRQERERQCREE 1113
Score = 47.4 bits (111), Expect = 3e-05
Identities = 61/260 (23%), Positives = 105/260 (40%), Gaps = 20/260 (7%)
Query: 76 EQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGER 135
+QLRRQE G Q R R E+L + ERE QQL Q ER+++ L + + E+
Sbjct: 1538 QQLRRQERGQQRRQDRDRKFREEEQLRQ-EREEQQLSRQ---ERDRKFRLEEQKVRRQEQ 1593
Query: 136 ARAASDVLCRSLANE-THQLR----RTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQS 190
R + + E QLR R + Q + RQ R E P
Sbjct: 1594 ERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLR 1653
Query: 191 EHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQI 250
K +EE +LL++ + Q RD R QLR +
Sbjct: 1654 RQEREQQLRHDRDRKFREEEQLLQE--------GEEQQLRRQERDRKFREEEQQLRRQE- 1704
Query: 251 PHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDF 310
E + +++E ++LE K + +++QE + R ++ + E+Q+ +++
Sbjct: 1705 -RERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKI-LEEEQLRPEREEQ 1762
Query: 311 MSERADRERAQSRIQELEEK 330
R +R+R ++L ++
Sbjct: 1763 QLRRQERDRKFREEEQLRQE 1782
Score = 47.0 bits (110), Expect = 3e-05
Identities = 58/274 (21%), Positives = 124/274 (45%), Gaps = 39/274 (14%)
Query: 69 EQVARFRE--QLRRQEGGAAEAQMRQEIERLTERLEEKE--------REMQQLLSQPQHE 118
E+ R RE +LRR+ + Q R+ +R+ + EEKE R+ ++ L + + +
Sbjct: 207 EEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ 266
Query: 119 REKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHA 178
R++E+ E E+ R R E Q ++ L + + + E+Q
Sbjct: 267 RQREL------QEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEE 320
Query: 179 QRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYV 238
+R ER Q E + + + QEE R +Q++ ++ + Q+ ++E
Sbjct: 321 RREQQERREQQEERR------EQQLRREQEERR--EQQLRREQEEERREQQLRREQEE-- 370
Query: 239 RGLHAQLRGLQIPHEPELMRKEISRLNRQL--EEKINDCAEVKQELAASRTARDAALERV 296
+ R Q+ E +L R++ R +QL E+++ ++++E + R+ L R
Sbjct: 371 -----ERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE---QQLRREQQLRRE 422
Query: 297 QMLEQQILAYKDDFMSERADRERAQSRIQELEEK 330
Q L ++ +++ ++ ++ER + R++ +E+
Sbjct: 423 QQLRRE---QEEERHEQKHEQERREQRLKREQEE 453
Score = 47.0 bits (110), Expect = 3e-05
Identities = 69/293 (23%), Positives = 119/293 (40%), Gaps = 42/293 (14%)
Query: 69 EQVARFRE---QLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQ------HER 119
E+ +FRE Q+RRQE E + +E ++L + K RE +QLL + + ER
Sbjct: 1427 ERDRKFREEEQQVRRQE---RERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQER 1483
Query: 120 EKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQ 179
+++ + + + ER R + RS E L H Q K L E Q +
Sbjct: 1484 DRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEE--EQQLHRQQRQRKFLQEEQQLR 1541
Query: 180 RNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVR 239
R ER + + D + + + +EE +L +Q+ D + + R E R
Sbjct: 1542 RQ--ERGQQRRQDRDRKFREEEQLRQEREEQQLSRQE----RDRKFRLEEQKVRRQEQER 1595
Query: 240 GLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAE------------VKQELAASRT 287
+ L+ + +R+E R R+ E+ + + E +++E R
Sbjct: 1596 KFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQ 1655
Query: 288 ARDAAL----ERVQMLEQQILAYKDDFMSERADRER------AQSRIQELEEK 330
R+ L +R E+Q+L ++ R +R+R Q R QE E K
Sbjct: 1656 EREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERK 1708
Score = 46.2 bits (108), Expect = 6e-05
Identities = 63/285 (22%), Positives = 115/285 (40%), Gaps = 21/285 (7%)
Query: 68 LEQVARFREQLRRQEGGAAEAQMR--QEIERLTERLEEKEREMQQLLSQPQHER-----E 120
LE+ R R Q R ++ E Q+R + ++L + + K RE +Q LS+ + +R E
Sbjct: 1377 LEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEE 1436
Query: 121 KEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQR 180
++V R E + R E L+ H + K L+E Q +R
Sbjct: 1437 QQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRR 1496
Query: 181 NVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRG 240
+R + E + + E+ Q + ++K E + +R R + R
Sbjct: 1497 QERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRK 1556
Query: 241 LHAQLRGLQIPHEPELMRKEISRLNRQLEEKI------NDCAEVKQELAASRTARDAALE 294
+ + Q E +L R+E R R E+K+ E +Q+L + E
Sbjct: 1557 FREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQE 1616
Query: 295 RVQML--EQQILAYKDDFMSERADRER------AQSRIQELEEKV 331
R + ++Q+L +++ R +R+R Q R QE E+++
Sbjct: 1617 RDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQL 1661
Score = 45.8 bits (107), Expect = 7e-05
Identities = 57/264 (21%), Positives = 116/264 (43%), Gaps = 15/264 (5%)
Query: 69 EQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRR 128
E+ R ++ +E E +R+E E+L E +++RE+Q+ Q + E++ + R
Sbjct: 232 ERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQ-LRKLERQELRRER 290
Query: 129 SMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDER--QHAQRNVGERS 186
E ++ R + + L + + RR Q + +ER Q +R ER
Sbjct: 291 QEEEQQQQRLRRE---QQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERR 347
Query: 187 PDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLR 246
Q + + + QEE R +Q++ + L + Q R++ +R R
Sbjct: 348 EQQLRREQEEERREQQLRREQEEER-REQQLRREQQLRREQQ---LRREQQLRREQQLRR 403
Query: 247 GLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAY 306
Q+ E +L R++ R +QL + E + E + R+ L+R Q + L
Sbjct: 404 EQQLRREQQLRREQQLRREQQLR---REQEEERHEQKHEQERREQRLKREQEERRDWLKR 460
Query: 307 KDDFMSERADRERAQSRIQELEEK 330
+++ +ER ++ER + +++ +E+
Sbjct: 461 EEE--TERHEQERRKQQLKRDQEE 482
Score = 45.1 bits (105), Expect = 1e-04
Identities = 84/353 (23%), Positives = 133/353 (37%), Gaps = 73/353 (20%)
Query: 26 EAGQRLRRLQDQLAARDALIARLRA--RLAALEGDAAPSLVDALL---EQVARFRE---Q 77
E GQ+ R+ +D+ + + + R +L+ E D L + + EQ +F E Q
Sbjct: 1544 ERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQ 1603
Query: 78 LRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLL------------------------- 112
LRRQEG + Q+RQE +R K RE +QLL
Sbjct: 1604 LRRQEG---QQQLRQERDR-------KFREDEQLLQEREEQQLHRQERDRKFLEEEPQLR 1653
Query: 113 -----SQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQH 167
Q +H+R+++ + + EGE + R E QLRR +
Sbjct: 1654 RQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ--------ER 1705
Query: 168 LAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKW 227
K L E Q +R ER + E T E+L+ + R +K+ E L +
Sbjct: 1706 ERKFLQEEQQLRRQELERKFREEEQLRQETEQ----EQLRRQERY--RKILEEEQLRPER 1759
Query: 228 QRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRT 287
+ R E R + + Q E +L +E R R+ EE++ E +Q R
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFRE-EEQLRQEREEQQLRPQQRD 1818
Query: 288 ARDAALERVQMLEQQILAYK----------DDFMSERADRERAQSRIQELEEK 330
+ E LE+Q + + F ++ R Q QE E+K
Sbjct: 1819 GKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQK 1871
Score = 43.5 bits (101), Expect = 4e-04
Identities = 68/310 (21%), Positives = 121/310 (39%), Gaps = 45/310 (14%)
Query: 70 QVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKER-----EMQQLLSQPQHE------ 118
++A EQ +QE + R++ E +R E +ER E +QL S HE
Sbjct: 147 ELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPD 206
Query: 119 ----REKEVVLLRRSMAE--GERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCL 172
R +E++ LRR E ++ R D + + + + R T+ + + K
Sbjct: 207 EEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETV-----LRKEEEKLQ 261
Query: 173 DERQHAQRNVGE--------------RSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVT 218
+E QR + E R + E + + + QEE R +++
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER--REQQE 319
Query: 219 HVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEV 278
+ + ++ R++ +R + R Q+ E E R+E Q EE+
Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRR 379
Query: 279 KQELAASRTARDAALERVQML--EQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
+Q+L R+ L R Q L EQQ+ + ++ RE+ R Q+L + H
Sbjct: 380 EQQL-----RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERH 434
Query: 337 QVSWRQDSRE 346
+ Q+ RE
Sbjct: 435 EQKHEQERRE 444
Score = 43.5 bits (101), Expect = 4e-04
Identities = 78/332 (23%), Positives = 140/332 (42%), Gaps = 41/332 (12%)
Query: 29 QRLRRLQDQLAARDALIARLRARLAALEGDAAPSLV----DALLEQVARFREQLRRQEGG 84
QRL+R +++ + L R +L + + L+ + LEQ R ++L+R++
Sbjct: 517 QRLKRQEEEERLQQRL--RSEQQLRREQEERREQLLKREEEKRLEQERR-EQRLKREQEE 573
Query: 85 AAEAQMRQEIERLTERLE-EKEREMQQLLSQPQHER----EKEVVLLRRSMAEGERARAA 139
+ +++E ER +RL+ E+E ++Q L + + ER E+ L+R E ER +
Sbjct: 574 RRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQ- 632
Query: 140 SDVLCRSLANE---THQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGH 196
L +S E QLRR Q L + +E + QR E ++ E
Sbjct: 633 ---LLKSEEQEERRQQQLRREQQERRE--QRLKREEEEERLEQRLKREHEEERREQELAE 687
Query: 197 TSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQR-YNASRDEYVRGLHAQLRGLQIPHEPE 255
+ E++ ++R+ K + + +A+ + Y+ R + + + + E E
Sbjct: 688 EEQEQARERI--KSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESE 745
Query: 256 LMRKEISRLNRQL--EEKINDC-----AEVKQELAASRTA----------RDAALERVQM 298
L +E R +RQ EE+ D AE K E R + R E Q
Sbjct: 746 LQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQ 805
Query: 299 LEQQILAYKDDFMSERADRERAQSRIQELEEK 330
EQ+ L +++ R R + +Q LEE+
Sbjct: 806 REQRFLPEEEEKEQRRRQRREREKELQFLEEE 837
Score = 42.7 bits (99), Expect = 6e-04
Identities = 57/284 (20%), Positives = 116/284 (40%), Gaps = 49/284 (17%)
Query: 69 EQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRR 128
EQ+ R + RR++ + + + E+++ E+L +ERE ++L + + RE+E +
Sbjct: 1001 EQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEE 1060
Query: 129 SMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPD 188
GE R Q R+ +E Q + + P+
Sbjct: 1061 EQLLGEERET------RRRQELERQYRKE---------------EELQQEEEQLLREEPE 1099
Query: 189 QSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGL 248
+ + + E QEE +LL++ +R R E R +
Sbjct: 1100 KRRRQERERQCREEEELQQEEEQLLRE------------EREKRRRQELERQYREEEEVQ 1147
Query: 249 QIPHEPELMRKEISRLNRQ-LEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYK 307
Q E +L+R+E + RQ LE + + E++QE + R+ +R Q E+Q Y+
Sbjct: 1148 Q--EEEQLLREEPEKRRRQELERQYREEEELQQE--EEQLLREEQEKRRQERERQ---YR 1200
Query: 308 DDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGR 351
++ E R++ + R ++ +++ + W+ + + +A R
Sbjct: 1201 EE---EELQRQKRKQRYRDEDQR-----SDLKWQWEPEKENAVR 1236
Score = 40.8 bits (94), Expect = 0.002
Identities = 73/305 (23%), Positives = 120/305 (39%), Gaps = 49/305 (16%)
Query: 69 EQVARFREQLRRQEGGAAEAQMRQEIERLT-----ERLEEKEREMQQLLSQPQHEREKEV 123
E+ R +L+ QE A Q ++E +R + E+ ER Q+L ++P ++E
Sbjct: 737 EKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRE- 795
Query: 124 VLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG 183
R + ER + L E Q RR Q L +E + QR
Sbjct: 796 ----RQLRAEERQQREQRFLPEE--EEKEQRRRQRREREKELQFL----EEEEQLQRR-- 843
Query: 184 ERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHA 243
ER+ E DG +++ QE R +Q+ D +WQ R L+A
Sbjct: 844 ERAQQLQEEEDG-------LQEDQERRRSQEQR----RDQKWRWQ-LEEERKRRRHTLYA 891
Query: 244 QLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQI 303
+ P E +RKE L + EE + E ++ R R+ E++Q E+Q+
Sbjct: 892 K------PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREE--EQLQQEEEQL 943
Query: 304 LAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLA 363
L R +RE+ + + +E + + L Q + EP+ R K KY
Sbjct: 944 L---------REEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREK--KYRE 992
Query: 364 ADALE 368
+ L+
Sbjct: 993 EEELQ 997
Score = 36.6 bits (83), Expect = 0.045
Identities = 58/252 (23%), Positives = 96/252 (38%), Gaps = 47/252 (18%)
Query: 73 RFREQLRRQEGGAAEAQMRQEIERL----TERLEEKEREMQQLLSQPQHEREKEVVLLRR 128
+FRE+ + + G + RQE +R ++L +ERE + L + Q R++ L R
Sbjct: 1668 KFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQE----LER 1723
Query: 129 SMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE-------------R 175
E E+ R + E QLRR + K L+E R
Sbjct: 1724 KFREEEQLRQET---------EQEQLRRQ--------ERYRKILEEEQLRPEREEQQLRR 1766
Query: 176 QHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKV-----THVEDLNAKWQRY 230
Q R E + E + Q K +EE +L +++ D +W+
Sbjct: 1767 QERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEE 1826
Query: 231 NASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARD 290
+E + L Q R Q E + +E S R+ E+++ E K+ R R+
Sbjct: 1827 QLQLEEQEQRLR-QERDRQYRAEEQFATQEKS---RREEQELWQEEEQKRRQERERKLRE 1882
Query: 291 AALERVQMLEQQ 302
+ R Q EQ+
Sbjct: 1883 EHIRRQQKEEQR 1894
Score = 29.3 bits (64), Expect = 7.2
Identities = 21/80 (26%), Positives = 38/80 (47%), Gaps = 12/80 (15%)
Query: 67 LLEQVARFRE----QLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKE 122
L EQ R R+ Q R +E A + + R+E + L + E+K R+ ++ + +H
Sbjct: 1830 LEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEH----- 1884
Query: 123 VVLLRRSMAEGERARAASDV 142
+RR E +R R ++
Sbjct: 1885 ---IRRQQKEEQRHRQVGEI 1901
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 59.7 bits (143), Expect = 5e-09
Identities = 87/366 (23%), Positives = 159/366 (43%), Gaps = 70/366 (19%)
Query: 10 WEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLE 69
WEE + AA L E GQ ++ +L+ +D + L+ +L L + S +
Sbjct: 454 WEELKKKAAGLQA---EIGQ----VKQELSRKDTELLALQTKLETLTNQFSDSK-----Q 501
Query: 70 QVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQ------------- 116
+ +E L +E AA Q E++ L RLEEKE + + Q Q
Sbjct: 502 HIEVLKESLTAKEQRAAILQT--EVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEI 559
Query: 117 HE-------REKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLA 169
H+ +E++V +L++ + + + SL L+ T T L
Sbjct: 560 HDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLE 619
Query: 170 KCLDERQHA-QRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQ 228
+ L E++ +R +R D+ E Q I+ +++ + LK+KV+ ++ ++ +
Sbjct: 620 EALAEKERTIERLKEQRDRDEREK-------QEEIDNYKKDLKDLKEKVSLLQGDLSEKE 672
Query: 229 RYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTA 288
E+ L + GL+ + L EI+ LE+K +C +++ +L + A
Sbjct: 673 ASLLDLKEHASSLASS--GLK--KDSRLKTLEIA-----LEQKKEECLKMESQL---KKA 720
Query: 289 RDAALE---------RVQMLEQQILAYKDDFMSERADRERAQSRIQELE-------EKVA 332
+AALE R+Q LE++I YKD+ +A+ +R ++E+E +K+A
Sbjct: 721 HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIA 780
Query: 333 SLLHQV 338
L QV
Sbjct: 781 ELERQV 786
Score = 43.9 bits (102), Expect = 3e-04
Identities = 61/307 (19%), Positives = 133/307 (43%), Gaps = 35/307 (11%)
Query: 64 VDALLEQVAR----FREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHER 119
+++LLEQ + RE++ R+ A ++ + ++ + E + K M++ L +
Sbjct: 346 LESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGL----RDL 401
Query: 120 EKEVVLLRRSMA----EGERARAASDVL---CRSLANETHQLRRTLTATAHMCQHLAKCL 172
E+E+ +L+ + A E E +V + + N+ QL+ L++ + L K
Sbjct: 402 EEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKK-- 459
Query: 173 DERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHV-EDLNAKWQRYN 231
+ Q +G+ + S ++Q+ +E L + KQ + + E L AK QR
Sbjct: 460 -KAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAA 518
Query: 232 ASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEK---------INDCAEVKQ-E 281
+ E L++ + ++ K+ ++ EEK + D +VK+ +
Sbjct: 519 ILQTE------VDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERK 572
Query: 282 LAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWR 341
+ + + E+++ E+Q+ + K+ S +AD + + LEE +A +
Sbjct: 573 VNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERL 632
Query: 342 QDSREPD 348
++ R+ D
Sbjct: 633 KEQRDRD 639
Score = 30.0 bits (66), Expect = 4.2
Identities = 52/245 (21%), Positives = 96/245 (39%), Gaps = 28/245 (11%)
Query: 25 HEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG 84
++ +++ L+ Q+ ++ +A L+ + + +A L +A R RE
Sbjct: 773 NDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEA------RRREDNLNDSSQ 826
Query: 85 AAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVL- 143
+ +R++ +R+ E LEE RE Q+ + E+E+VL + A + ++L
Sbjct: 827 QLQDSLRKKDDRI-EELEEALRESVQITA------EREMVLAQEESARTNAEKQVEELLM 879
Query: 144 -CRSLANETHQLRRTLTAT----AHMCQHLAKCLDERQHAQRNVGERSPD-------QSE 191
+ E ++ L++T A HL ER+ V E + + +
Sbjct: 880 AMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKD 939
Query: 192 HTDGHTSVQSVIEKLQEENRLLK-QKVTHVEDLNAKWQ-RYNASRDEYVRGLHAQLRGLQ 249
+ S +K QEE LK +K V+ L + Q R D Y Q
Sbjct: 940 ANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQ 999
Query: 250 IPHEP 254
H+P
Sbjct: 1000 TNHKP 1004
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 59.7 bits (143), Expect = 5e-09
Identities = 88/386 (22%), Positives = 158/386 (40%), Gaps = 47/386 (12%)
Query: 2 SRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAP 61
S+D E ++ AL T E +L L+D+L A + RL + AL+G
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578
Query: 62 SLVDALLEQVARFREQLRRQEGGAAEAQMRQEIER--------LTERLEEKEREMQQLLS 113
L A EQ R QL+RQ E + E ER ++LE ++++
Sbjct: 1579 DL-QARDEQNEEKRRQLQRQ---LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1634
Query: 114 QPQHEREKEVVLLRRSMA-------EGERARAASDVLCRSLANETHQLRRTLTATAHMCQ 166
RE+ + LR+ A E E ARA+ D + + A E + ++L A Q
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF-ATAKENEKKAKSLEADLMQLQ 1693
Query: 167 H-LAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225
LA R+ A E + + + G + LQ+E R L+ ++ +E+
Sbjct: 1694 EDLAAAERARKQADLEKEELAEELASSLSGRNA-------LQDEKRRLEARIAQLEEELE 1746
Query: 226 KWQRYNASRDEYVRGLHAQLRGL--------QIPHEPELMRKEISRLNRQLEEKINDC-A 276
+ Q + + VR Q L + E R+++ R N++L K+++
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1806
Query: 277 EVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
VK + ++ A +A ++ LE+Q+ E +++ A +++ ++K+ +L
Sbjct: 1807 AVKSKFKSTIAALEA---KIAQLEEQV-------EQEAREKQAATKSLKQKDKKLKEILL 1856
Query: 337 QVSWRQDSREPDAGRIHAGSKTAKYL 362
QV + E + G+ K L
Sbjct: 1857 QVEDERKMAEQYKEQAEKGNARVKQL 1882
Score = 52.8 bits (125), Expect = 6e-07
Identities = 72/362 (19%), Positives = 153/362 (42%), Gaps = 39/362 (10%)
Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPS-------- 62
+E R + T + + LQDQL L ++ L + S
Sbjct: 1325 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1384
Query: 63 -LVDALLEQVARFREQLRR-----QEGGAA-------EAQMRQEIE----------RLTE 99
V+AL E RF++++ +E AA + +++QE++ +L
Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444
Query: 100 RLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLT 159
LE+K+R+ QLL++ ++ K R+ AE + L R+L E + + L
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL-EEALEAKEELE 1503
Query: 160 ATAHMCQ-HLAKCLDERQHAQRNVGERSPD----QSEHTDGHTSVQSVIEKLQEENRLLK 214
T M + + + + +NV E +++ + T ++ + ++LQ
Sbjct: 1504 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1563
Query: 215 QKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPEL--MRKEISRLNRQLEEKI 272
+ +++ L +++R +RDE QL+ +E EL RK+ + ++
Sbjct: 1564 RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1623
Query: 273 NDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVA 332
D +++ + ++ R+ A+++++ L+ Q+ ++ + RA R+ + +E E+K
Sbjct: 1624 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1683
Query: 333 SL 334
SL
Sbjct: 1684 SL 1685
Score = 51.6 bits (122), Expect = 1e-06
Identities = 65/266 (24%), Positives = 122/266 (45%), Gaps = 24/266 (9%)
Query: 85 AAEAQMRQEI-ERLTERLEEKEREMQQLLSQPQHEREK---EVVLLRRSMAEGERARAAS 140
AA+ Q +EI + RLEE+E QQL Q ER+K +++ L + E E AR
Sbjct: 914 AAKKQELEEILHEMEARLEEEEDRGQQL----QAERKKMAQQMLDLEEQLEEEEAAR--- 966
Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQ 200
+ QL + +TA A + + + L + ER + +D T++
Sbjct: 967 ---------QKLQLEK-VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1016
Query: 201 SVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPEL--MR 258
EK + +L + + + +L + ++ SR E + L +L G ++ ++
Sbjct: 1017 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKLEGDASDFHEQIADLQ 1075
Query: 259 KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRE 318
+I+ L QL +K + L ++ AL++++ LE I ++D SERA R
Sbjct: 1076 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1135
Query: 319 RAQSRIQELEEKVASLLHQVSWRQDS 344
+A+ + ++L E++ +L ++ DS
Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTLDS 1161
Score = 47.4 bits (111), Expect = 3e-05
Identities = 75/356 (21%), Positives = 148/356 (41%), Gaps = 61/356 (17%)
Query: 31 LRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG------ 84
L RL D++A ++ + ++R LEG + D E+ AR + + ++++ G
Sbjct: 1096 LARLDDEIAQKNNALKKIRE----LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1151
Query: 85 -----------AAEAQMR----QEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRS 129
A + ++R QE+ L + L+E+ R + + + + + + V L
Sbjct: 1152 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1211
Query: 130 MAEGERARAASDVLCRSLANETHQLR---RTLTATAHMCQHLAKCLDER-QHAQRNVGER 185
+ + +RA+A D ++L E L R L +H K L+ + Q Q +
Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271
Query: 186 SPDQSEHTDGHTSVQSVIE--------------KLQEENRLLKQKVTHVEDLNAKWQRYN 231
++E D +Q+ +E KL ++ L ++ ++L + R
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331
Query: 232 ASRDEYVRGLHAQLRGLQIPHEPEL-----MRKEISRLNRQL---EEKINDCAEVKQELA 283
+ +R L + LQ + E+ + + IS LN QL ++K+ D A + L
Sbjct: 1332 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1391
Query: 284 ASRTARDAALERV-QMLEQQILAYKDDFMSERADRERAQSRI-QELEEKVASLLHQ 337
+ +E + Q E++ AY E+ ++R+ QEL++ V L +Q
Sbjct: 1392 EGKKRFQKEIENLTQQYEEKAAAYD--------KLEKTKNRLQQELDDLVVDLDNQ 1439
Score = 41.2 bits (95), Expect = 0.002
Identities = 56/276 (20%), Positives = 110/276 (39%), Gaps = 45/276 (16%)
Query: 32 RRLQDQLAARDALIARLRA---RLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEA 88
R L+D A+RD + A + + +LE D D + AR + L ++E A
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 89 --------------QMRQEIERLTERLEEKEREMQQL------LSQPQHEREKEVVLLRR 128
++ I +L E LEE++ M+ + +Q + E+ R
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778
Query: 129 SMAEGERARAASDVLCRSLANETHQL--------RRTLTATAHMCQHLAKCLD----ERQ 176
+ + E AR + + L ++ H++ + T+ A L + ++ E+Q
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838
Query: 177 HAQRNVGERSPDQSEHT----DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNA 232
A +++ ++ E D + E+ ++ N +KQ +E+ + QR NA
Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898
Query: 233 SRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQL 268
+R + R L + E M +E++ L +L
Sbjct: 1899 NRRKLQRELD------EATESNEAMGREVNALKSKL 1928
Score = 29.6 bits (65), Expect = 5.5
Identities = 17/77 (22%), Positives = 39/77 (50%)
Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRI 352
L +V E+++ A +D+ + +++A++ ++ELE+K + L + + Q+ + +
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 353 HAGSKTAKYLAADALEL 369
+ LAA EL
Sbjct: 904 AEAEEMRVRLAAKKQEL 920
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 59.7 bits (143), Expect = 5e-09
Identities = 88/386 (22%), Positives = 158/386 (40%), Gaps = 47/386 (12%)
Query: 2 SRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAP 61
S+D E ++ AL T E +L L+D+L A + RL + AL+G
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585
Query: 62 SLVDALLEQVARFREQLRRQEGGAAEAQMRQEIER--------LTERLEEKEREMQQLLS 113
L A EQ R QL+RQ E + E ER ++LE ++++
Sbjct: 1586 DL-QARDEQNEEKRRQLQRQ---LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1641
Query: 114 QPQHEREKEVVLLRRSMA-------EGERARAASDVLCRSLANETHQLRRTLTATAHMCQ 166
RE+ + LR+ A E E ARA+ D + + A E + ++L A Q
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF-ATAKENEKKAKSLEADLMQLQ 1700
Query: 167 H-LAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225
LA R+ A E + + + G + LQ+E R L+ ++ +E+
Sbjct: 1701 EDLAAAERARKQADLEKEELAEELASSLSGRNA-------LQDEKRRLEARIAQLEEELE 1753
Query: 226 KWQRYNASRDEYVRGLHAQLRGL--------QIPHEPELMRKEISRLNRQLEEKINDC-A 276
+ Q + + VR Q L + E R+++ R N++L K+++
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1813
Query: 277 EVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
VK + ++ A +A ++ LE+Q+ E +++ A +++ ++K+ +L
Sbjct: 1814 AVKSKFKSTIAALEA---KIAQLEEQV-------EQEAREKQAATKSLKQKDKKLKEILL 1863
Query: 337 QVSWRQDSREPDAGRIHAGSKTAKYL 362
QV + E + G+ K L
Sbjct: 1864 QVEDERKMAEQYKEQAEKGNARVKQL 1889
Score = 52.8 bits (125), Expect = 6e-07
Identities = 72/362 (19%), Positives = 153/362 (42%), Gaps = 39/362 (10%)
Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPS-------- 62
+E R + T + + LQDQL L ++ L + S
Sbjct: 1332 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391
Query: 63 -LVDALLEQVARFREQLRR-----QEGGAA-------EAQMRQEIE----------RLTE 99
V+AL E RF++++ +E AA + +++QE++ +L
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451
Query: 100 RLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLT 159
LE+K+R+ QLL++ ++ K R+ AE + L R+L E + + L
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL-EEALEAKEELE 1510
Query: 160 ATAHMCQ-HLAKCLDERQHAQRNVGERSPD----QSEHTDGHTSVQSVIEKLQEENRLLK 214
T M + + + + +NV E +++ + T ++ + ++LQ
Sbjct: 1511 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1570
Query: 215 QKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPEL--MRKEISRLNRQLEEKI 272
+ +++ L +++R +RDE QL+ +E EL RK+ + ++
Sbjct: 1571 RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1630
Query: 273 NDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVA 332
D +++ + ++ R+ A+++++ L+ Q+ ++ + RA R+ + +E E+K
Sbjct: 1631 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1690
Query: 333 SL 334
SL
Sbjct: 1691 SL 1692
Score = 51.6 bits (122), Expect = 1e-06
Identities = 65/266 (24%), Positives = 122/266 (45%), Gaps = 24/266 (9%)
Query: 85 AAEAQMRQEI-ERLTERLEEKEREMQQLLSQPQHEREK---EVVLLRRSMAEGERARAAS 140
AA+ Q +EI + RLEE+E QQL Q ER+K +++ L + E E AR
Sbjct: 921 AAKKQELEEILHEMEARLEEEEDRGQQL----QAERKKMAQQMLDLEEQLEEEEAAR--- 973
Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQ 200
+ QL + +TA A + + + L + ER + +D T++
Sbjct: 974 ---------QKLQLEK-VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1023
Query: 201 SVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPEL--MR 258
EK + +L + + + +L + ++ SR E + L +L G ++ ++
Sbjct: 1024 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKLEGDASDFHEQIADLQ 1082
Query: 259 KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRE 318
+I+ L QL +K + L ++ AL++++ LE I ++D SERA R
Sbjct: 1083 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1142
Query: 319 RAQSRIQELEEKVASLLHQVSWRQDS 344
+A+ + ++L E++ +L ++ DS
Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTLDS 1168
Score = 47.4 bits (111), Expect = 3e-05
Identities = 75/356 (21%), Positives = 148/356 (41%), Gaps = 61/356 (17%)
Query: 31 LRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG------ 84
L RL D++A ++ + ++R LEG + D E+ AR + + ++++ G
Sbjct: 1103 LARLDDEIAQKNNALKKIRE----LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1158
Query: 85 -----------AAEAQMR----QEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRS 129
A + ++R QE+ L + L+E+ R + + + + + + V L
Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218
Query: 130 MAEGERARAASDVLCRSLANETHQLR---RTLTATAHMCQHLAKCLDER-QHAQRNVGER 185
+ + +RA+A D ++L E L R L +H K L+ + Q Q +
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278
Query: 186 SPDQSEHTDGHTSVQSVIE--------------KLQEENRLLKQKVTHVEDLNAKWQRYN 231
++E D +Q+ +E KL ++ L ++ ++L + R
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338
Query: 232 ASRDEYVRGLHAQLRGLQIPHEPEL-----MRKEISRLNRQL---EEKINDCAEVKQELA 283
+ +R L + LQ + E+ + + IS LN QL ++K+ D A + L
Sbjct: 1339 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1398
Query: 284 ASRTARDAALERV-QMLEQQILAYKDDFMSERADRERAQSRI-QELEEKVASLLHQ 337
+ +E + Q E++ AY E+ ++R+ QEL++ V L +Q
Sbjct: 1399 EGKKRFQKEIENLTQQYEEKAAAYD--------KLEKTKNRLQQELDDLVVDLDNQ 1446
Score = 41.2 bits (95), Expect = 0.002
Identities = 56/276 (20%), Positives = 110/276 (39%), Gaps = 45/276 (16%)
Query: 32 RRLQDQLAARDALIARLRA---RLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEA 88
R L+D A+RD + A + + +LE D D + AR + L ++E A
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 89 --------------QMRQEIERLTERLEEKEREMQQL------LSQPQHEREKEVVLLRR 128
++ I +L E LEE++ M+ + +Q + E+ R
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785
Query: 129 SMAEGERARAASDVLCRSLANETHQL--------RRTLTATAHMCQHLAKCLD----ERQ 176
+ + E AR + + L ++ H++ + T+ A L + ++ E+Q
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845
Query: 177 HAQRNVGERSPDQSEHT----DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNA 232
A +++ ++ E D + E+ ++ N +KQ +E+ + QR NA
Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905
Query: 233 SRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQL 268
+R + R L + E M +E++ L +L
Sbjct: 1906 NRRKLQRELD------EATESNEAMGREVNALKSKL 1935
Score = 29.6 bits (65), Expect = 5.5
Identities = 17/77 (22%), Positives = 39/77 (50%)
Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRI 352
L +V E+++ A +D+ + +++A++ ++ELE+K + L + + Q+ + +
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 353 HAGSKTAKYLAADALEL 369
+ LAA EL
Sbjct: 911 AEAEEMRVRLAAKKQEL 927
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 59.7 bits (143), Expect = 5e-09
Identities = 88/386 (22%), Positives = 158/386 (40%), Gaps = 47/386 (12%)
Query: 2 SRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAP 61
S+D E ++ AL T E +L L+D+L A + RL + AL+G
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585
Query: 62 SLVDALLEQVARFREQLRRQEGGAAEAQMRQEIER--------LTERLEEKEREMQQLLS 113
L A EQ R QL+RQ E + E ER ++LE ++++
Sbjct: 1586 DL-QARDEQNEEKRRQLQRQ---LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1641
Query: 114 QPQHEREKEVVLLRRSMA-------EGERARAASDVLCRSLANETHQLRRTLTATAHMCQ 166
RE+ + LR+ A E E ARA+ D + + A E + ++L A Q
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF-ATAKENEKKAKSLEADLMQLQ 1700
Query: 167 H-LAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225
LA R+ A E + + + G + LQ+E R L+ ++ +E+
Sbjct: 1701 EDLAAAERARKQADLEKEELAEELASSLSGRNA-------LQDEKRRLEARIAQLEEELE 1753
Query: 226 KWQRYNASRDEYVRGLHAQLRGL--------QIPHEPELMRKEISRLNRQLEEKINDC-A 276
+ Q + + VR Q L + E R+++ R N++L K+++
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1813
Query: 277 EVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
VK + ++ A +A ++ LE+Q+ E +++ A +++ ++K+ +L
Sbjct: 1814 AVKSKFKSTIAALEA---KIAQLEEQV-------EQEAREKQAATKSLKQKDKKLKEILL 1863
Query: 337 QVSWRQDSREPDAGRIHAGSKTAKYL 362
QV + E + G+ K L
Sbjct: 1864 QVEDERKMAEQYKEQAEKGNARVKQL 1889
Score = 52.8 bits (125), Expect = 6e-07
Identities = 72/362 (19%), Positives = 153/362 (42%), Gaps = 39/362 (10%)
Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPS-------- 62
+E R + T + + LQDQL L ++ L + S
Sbjct: 1332 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391
Query: 63 -LVDALLEQVARFREQLRR-----QEGGAA-------EAQMRQEIE----------RLTE 99
V+AL E RF++++ +E AA + +++QE++ +L
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451
Query: 100 RLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLT 159
LE+K+R+ QLL++ ++ K R+ AE + L R+L E + + L
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL-EEALEAKEELE 1510
Query: 160 ATAHMCQ-HLAKCLDERQHAQRNVGERSPD----QSEHTDGHTSVQSVIEKLQEENRLLK 214
T M + + + + +NV E +++ + T ++ + ++LQ
Sbjct: 1511 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1570
Query: 215 QKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPEL--MRKEISRLNRQLEEKI 272
+ +++ L +++R +RDE QL+ +E EL RK+ + ++
Sbjct: 1571 RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1630
Query: 273 NDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVA 332
D +++ + ++ R+ A+++++ L+ Q+ ++ + RA R+ + +E E+K
Sbjct: 1631 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1690
Query: 333 SL 334
SL
Sbjct: 1691 SL 1692
Score = 51.6 bits (122), Expect = 1e-06
Identities = 65/266 (24%), Positives = 122/266 (45%), Gaps = 24/266 (9%)
Query: 85 AAEAQMRQEI-ERLTERLEEKEREMQQLLSQPQHEREK---EVVLLRRSMAEGERARAAS 140
AA+ Q +EI + RLEE+E QQL Q ER+K +++ L + E E AR
Sbjct: 921 AAKKQELEEILHEMEARLEEEEDRGQQL----QAERKKMAQQMLDLEEQLEEEEAAR--- 973
Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQ 200
+ QL + +TA A + + + L + ER + +D T++
Sbjct: 974 ---------QKLQLEK-VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1023
Query: 201 SVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPEL--MR 258
EK + +L + + + +L + ++ SR E + L +L G ++ ++
Sbjct: 1024 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKLEGDASDFHEQIADLQ 1082
Query: 259 KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRE 318
+I+ L QL +K + L ++ AL++++ LE I ++D SERA R
Sbjct: 1083 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1142
Query: 319 RAQSRIQELEEKVASLLHQVSWRQDS 344
+A+ + ++L E++ +L ++ DS
Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTLDS 1168
Score = 47.4 bits (111), Expect = 3e-05
Identities = 75/356 (21%), Positives = 148/356 (41%), Gaps = 61/356 (17%)
Query: 31 LRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG------ 84
L RL D++A ++ + ++R LEG + D E+ AR + + ++++ G
Sbjct: 1103 LARLDDEIAQKNNALKKIRE----LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1158
Query: 85 -----------AAEAQMR----QEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRS 129
A + ++R QE+ L + L+E+ R + + + + + + V L
Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218
Query: 130 MAEGERARAASDVLCRSLANETHQLR---RTLTATAHMCQHLAKCLDER-QHAQRNVGER 185
+ + +RA+A D ++L E L R L +H K L+ + Q Q +
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278
Query: 186 SPDQSEHTDGHTSVQSVIE--------------KLQEENRLLKQKVTHVEDLNAKWQRYN 231
++E D +Q+ +E KL ++ L ++ ++L + R
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338
Query: 232 ASRDEYVRGLHAQLRGLQIPHEPEL-----MRKEISRLNRQL---EEKINDCAEVKQELA 283
+ +R L + LQ + E+ + + IS LN QL ++K+ D A + L
Sbjct: 1339 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1398
Query: 284 ASRTARDAALERV-QMLEQQILAYKDDFMSERADRERAQSRI-QELEEKVASLLHQ 337
+ +E + Q E++ AY E+ ++R+ QEL++ V L +Q
Sbjct: 1399 EGKKRFQKEIENLTQQYEEKAAAYD--------KLEKTKNRLQQELDDLVVDLDNQ 1446
Score = 41.2 bits (95), Expect = 0.002
Identities = 56/276 (20%), Positives = 110/276 (39%), Gaps = 45/276 (16%)
Query: 32 RRLQDQLAARDALIARLRA---RLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEA 88
R L+D A+RD + A + + +LE D D + AR + L ++E A
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 89 --------------QMRQEIERLTERLEEKEREMQQL------LSQPQHEREKEVVLLRR 128
++ I +L E LEE++ M+ + +Q + E+ R
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785
Query: 129 SMAEGERARAASDVLCRSLANETHQL--------RRTLTATAHMCQHLAKCLD----ERQ 176
+ + E AR + + L ++ H++ + T+ A L + ++ E+Q
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845
Query: 177 HAQRNVGERSPDQSEHT----DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNA 232
A +++ ++ E D + E+ ++ N +KQ +E+ + QR NA
Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905
Query: 233 SRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQL 268
+R + R L + E M +E++ L +L
Sbjct: 1906 NRRKLQRELD------EATESNEAMGREVNALKSKL 1935
Score = 29.6 bits (65), Expect = 5.5
Identities = 17/77 (22%), Positives = 39/77 (50%)
Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRI 352
L +V E+++ A +D+ + +++A++ ++ELE+K + L + + Q+ + +
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 353 HAGSKTAKYLAADALEL 369
+ LAA EL
Sbjct: 911 AEAEEMRVRLAAKKQEL 927
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 59.7 bits (143), Expect = 5e-09
Identities = 88/386 (22%), Positives = 158/386 (40%), Gaps = 47/386 (12%)
Query: 2 SRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAP 61
S+D E ++ AL T E +L L+D+L A + RL + AL+G
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578
Query: 62 SLVDALLEQVARFREQLRRQEGGAAEAQMRQEIER--------LTERLEEKEREMQQLLS 113
L A EQ R QL+RQ E + E ER ++LE ++++
Sbjct: 1579 DL-QARDEQNEEKRRQLQRQ---LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1634
Query: 114 QPQHEREKEVVLLRRSMA-------EGERARAASDVLCRSLANETHQLRRTLTATAHMCQ 166
RE+ + LR+ A E E ARA+ D + + A E + ++L A Q
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF-ATAKENEKKAKSLEADLMQLQ 1693
Query: 167 H-LAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNA 225
LA R+ A E + + + G + LQ+E R L+ ++ +E+
Sbjct: 1694 EDLAAAERARKQADLEKEELAEELASSLSGRNA-------LQDEKRRLEARIAQLEEELE 1746
Query: 226 KWQRYNASRDEYVRGLHAQLRGL--------QIPHEPELMRKEISRLNRQLEEKINDC-A 276
+ Q + + VR Q L + E R+++ R N++L K+++
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1806
Query: 277 EVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLH 336
VK + ++ A +A ++ LE+Q+ E +++ A +++ ++K+ +L
Sbjct: 1807 AVKSKFKSTIAALEA---KIAQLEEQV-------EQEAREKQAATKSLKQKDKKLKEILL 1856
Query: 337 QVSWRQDSREPDAGRIHAGSKTAKYL 362
QV + E + G+ K L
Sbjct: 1857 QVEDERKMAEQYKEQAEKGNARVKQL 1882
Score = 52.8 bits (125), Expect = 6e-07
Identities = 72/362 (19%), Positives = 153/362 (42%), Gaps = 39/362 (10%)
Query: 11 EEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPS-------- 62
+E R + T + + LQDQL L ++ L + S
Sbjct: 1325 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1384
Query: 63 -LVDALLEQVARFREQLRR-----QEGGAA-------EAQMRQEIE----------RLTE 99
V+AL E RF++++ +E AA + +++QE++ +L
Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444
Query: 100 RLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLT 159
LE+K+R+ QLL++ ++ K R+ AE + L R+L E + + L
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL-EEALEAKEELE 1503
Query: 160 ATAHMCQ-HLAKCLDERQHAQRNVGERSPD----QSEHTDGHTSVQSVIEKLQEENRLLK 214
T M + + + + +NV E +++ + T ++ + ++LQ
Sbjct: 1504 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1563
Query: 215 QKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPEL--MRKEISRLNRQLEEKI 272
+ +++ L +++R +RDE QL+ +E EL RK+ + ++
Sbjct: 1564 RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1623
Query: 273 NDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVA 332
D +++ + ++ R+ A+++++ L+ Q+ ++ + RA R+ + +E E+K
Sbjct: 1624 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1683
Query: 333 SL 334
SL
Sbjct: 1684 SL 1685
Score = 51.6 bits (122), Expect = 1e-06
Identities = 65/266 (24%), Positives = 122/266 (45%), Gaps = 24/266 (9%)
Query: 85 AAEAQMRQEI-ERLTERLEEKEREMQQLLSQPQHEREK---EVVLLRRSMAEGERARAAS 140
AA+ Q +EI + RLEE+E QQL Q ER+K +++ L + E E AR
Sbjct: 914 AAKKQELEEILHEMEARLEEEEDRGQQL----QAERKKMAQQMLDLEEQLEEEEAAR--- 966
Query: 141 DVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQ 200
+ QL + +TA A + + + L + ER + +D T++
Sbjct: 967 ---------QKLQLEK-VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1016
Query: 201 SVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPEL--MR 258
EK + +L + + + +L + ++ SR E + L +L G ++ ++
Sbjct: 1017 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKLEGDASDFHEQIADLQ 1075
Query: 259 KEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRE 318
+I+ L QL +K + L ++ AL++++ LE I ++D SERA R
Sbjct: 1076 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1135
Query: 319 RAQSRIQELEEKVASLLHQVSWRQDS 344
+A+ + ++L E++ +L ++ DS
Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTLDS 1161
Score = 47.4 bits (111), Expect = 3e-05
Identities = 75/356 (21%), Positives = 148/356 (41%), Gaps = 61/356 (17%)
Query: 31 LRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGG------ 84
L RL D++A ++ + ++R LEG + D E+ AR + + ++++ G
Sbjct: 1096 LARLDDEIAQKNNALKKIRE----LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1151
Query: 85 -----------AAEAQMR----QEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRS 129
A + ++R QE+ L + L+E+ R + + + + + + V L
Sbjct: 1152 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1211
Query: 130 MAEGERARAASDVLCRSLANETHQLR---RTLTATAHMCQHLAKCLDER-QHAQRNVGER 185
+ + +RA+A D ++L E L R L +H K L+ + Q Q +
Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271
Query: 186 SPDQSEHTDGHTSVQSVIE--------------KLQEENRLLKQKVTHVEDLNAKWQRYN 231
++E D +Q+ +E KL ++ L ++ ++L + R
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331
Query: 232 ASRDEYVRGLHAQLRGLQIPHEPEL-----MRKEISRLNRQL---EEKINDCAEVKQELA 283
+ +R L + LQ + E+ + + IS LN QL ++K+ D A + L
Sbjct: 1332 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1391
Query: 284 ASRTARDAALERV-QMLEQQILAYKDDFMSERADRERAQSRI-QELEEKVASLLHQ 337
+ +E + Q E++ AY E+ ++R+ QEL++ V L +Q
Sbjct: 1392 EGKKRFQKEIENLTQQYEEKAAAYD--------KLEKTKNRLQQELDDLVVDLDNQ 1439
Score = 41.2 bits (95), Expect = 0.002
Identities = 56/276 (20%), Positives = 110/276 (39%), Gaps = 45/276 (16%)
Query: 32 RRLQDQLAARDALIARLRA---RLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEA 88
R L+D A+RD + A + + +LE D D + AR + L ++E A
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 89 --------------QMRQEIERLTERLEEKEREMQQL------LSQPQHEREKEVVLLRR 128
++ I +L E LEE++ M+ + +Q + E+ R
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778
Query: 129 SMAEGERARAASDVLCRSLANETHQL--------RRTLTATAHMCQHLAKCLD----ERQ 176
+ + E AR + + L ++ H++ + T+ A L + ++ E+Q
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838
Query: 177 HAQRNVGERSPDQSEHT----DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNA 232
A +++ ++ E D + E+ ++ N +KQ +E+ + QR NA
Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898
Query: 233 SRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQL 268
+R + R L + E M +E++ L +L
Sbjct: 1899 NRRKLQRELD------EATESNEAMGREVNALKSKL 1928
Score = 29.6 bits (65), Expect = 5.5
Identities = 17/77 (22%), Positives = 39/77 (50%)
Query: 293 LERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRI 352
L +V E+++ A +D+ + +++A++ ++ELE+K + L + + Q+ + +
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 353 HAGSKTAKYLAADALEL 369
+ LAA EL
Sbjct: 904 AEAEEMRVRLAAKKQEL 920
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 59.7 bits (143), Expect = 5e-09
Identities = 71/329 (21%), Positives = 149/329 (45%), Gaps = 34/329 (10%)
Query: 23 LYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSL-----VDALLEQVARFREQ 77
L E ++L+ ++L R +A+L+ ++ L+GD A + + + Q+
Sbjct: 826 LLQEENEKLQGRSEELERR---VAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVH 882
Query: 78 LRRQEGGAAEAQ--MRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLR-RSMAEGE 134
R++E A A+ + E+E L + +E +QL + + E E++ L R ++ E E
Sbjct: 883 ARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENE 942
Query: 135 RARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDE-RQHAQRNVGERSPDQSEHT 193
R L +++ ++ + A+ L LDE ++ +R + E E T
Sbjct: 943 RWH-----LGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKT 997
Query: 194 DGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRG---LHAQLRGLQI 250
+ K+Q+E RL+++++ + Y ++DE + L L+ L+
Sbjct: 998 LEAEKSRLTAMKMQDEMRLMEEEL----------RDYQRAQDEALTKRQLLEQTLKDLEY 1047
Query: 251 PHEPEL-MRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDD 309
E + ++ + SRL +Q+E+K++ +++ EL R D ER+ +Q+ +++
Sbjct: 1048 ELEAKSHLKDDRSRLVKQMEDKVS---QLEMELEEERNNSDLLSERISRSREQMEQLRNE 1104
Query: 310 FMSERADRERAQSRIQELEEKVASLLHQV 338
+ ERA R+ + LE + L ++
Sbjct: 1105 LLQERAARQDLECDKISLERQNKDLKSRI 1133
Score = 57.4 bits (137), Expect = 2e-08
Identities = 82/389 (21%), Positives = 168/389 (43%), Gaps = 52/389 (13%)
Query: 23 LYHEAGQRLRRLQDQLAARDALIARLRAR---LAALEGDAAPSLVDALLEQVARFREQLR 79
L E Q + LQD L A++ LR R L AL+G AL E+V+ +++
Sbjct: 728 LIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKG--------ALKEEVSSHDQEMD 779
Query: 80 R-QEGGAAEAQ-MRQEIERLTERLE------------EKEREMQQLLSQPQHER------ 119
+ +E AE Q +R+ +E T+ +E + EM+ L Q ++E+
Sbjct: 780 KLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSE 839
Query: 120 --EKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCL----D 173
E+ V L+R + + + A + + E QL L + +
Sbjct: 840 ELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALEN 899
Query: 174 ERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNAS 233
E + AQ N+ + + +Q + ++ E+L+ ++ + H+ K Q+ A
Sbjct: 900 ELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMAD 959
Query: 234 RDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAE--------------VK 279
E R +L+ Q+ E R+E++ + RQL+EK + + ++
Sbjct: 960 IVEASRTSTLELQN-QLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLME 1018
Query: 280 QELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVS 339
+EL + A+D AL + Q+LEQ + + + ++ ++ ++++E+KV+ L ++
Sbjct: 1019 EELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELE 1078
Query: 340 WRQDSREPDAGRIHAGSKTAKYLAADALE 368
+++ + + RI + + L + L+
Sbjct: 1079 EERNNSDLLSERISRSREQMEQLRNELLQ 1107
Score = 32.7 bits (73), Expect = 0.65
Identities = 62/295 (21%), Positives = 113/295 (38%), Gaps = 39/295 (13%)
Query: 69 EQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQP-----QHEREKEV 123
+ V R +L+ GA+ A R + ++ E E + + + Q ++E+EV
Sbjct: 438 QSVGRTFAKLQGAAHGASCAHSRPPQPNIDGKVLETEGSQESTVIRAPSLGAQSKKEEEV 497
Query: 124 VLLRRSMAEGERARAAS-DVLCRSLANETHQLRRTLTATAHMC---QHLAKCLDE---RQ 176
++ RA A S D + ++ +T AT + Q L + +E +Q
Sbjct: 498 KTATATLMLQNRATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQ 557
Query: 177 HAQRNVGERSPDQSEHTDGHTSVQSVIEKLQ----------EENRLLKQKVTHVEDLNAK 226
+ E S D + T V V EK+Q + N + V+DL +
Sbjct: 558 ILYNYLKEGSTDNDDATK--RKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQ 615
Query: 227 WQRYNASRDEYVRGLHAQLRGLQ-IPHEPELMR--------------KEISRLNRQLEEK 271
+ E R L +++ Q I E E MR +E S L ++LEE
Sbjct: 616 KSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEES 675
Query: 272 INDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQE 326
+ + +EL + R+ ++ L+ Q+ D+ S + +R + + E
Sbjct: 676 EGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIE 730
Score = 30.0 bits (66), Expect = 4.2
Identities = 34/141 (24%), Positives = 62/141 (43%), Gaps = 24/141 (17%)
Query: 89 QMRQEIERLTERLEEKEREMQQL-LSQPQHERE-KEVVLLRRSMAEGERARAASDVLCRS 146
QM I L +RLE +ER+ L LS + ER+ KE+V+ + E S
Sbjct: 1150 QMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVM----QVDDEHL---------S 1196
Query: 147 LANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVG---ERSPDQSEHTDGHTSVQSVI 203
L ++ QL L A + + +D + +++ + E D +EH G +
Sbjct: 1197 LTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQ------L 1250
Query: 204 EKLQEENRLLKQKVTHVEDLN 224
++++ RL K ++D++
Sbjct: 1251 NSMKKDLRLKKLPSKVLDDMD 1271
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.129 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,045,257
Number of Sequences: 37866
Number of extensions: 812509
Number of successful extensions: 10821
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 162
Number of HSP's successfully gapped in prelim test: 795
Number of HSP's that attempted gapping in prelim test: 6520
Number of HSP's gapped (non-prelim): 3020
length of query: 429
length of database: 18,247,518
effective HSP length: 105
effective length of query: 324
effective length of database: 14,271,588
effective search space: 4623994512
effective search space used: 4623994512
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.