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Search of human proteins with 119943118
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|119943118 cystinosis, nephropathic isoform 1 [Homo sapiens]
(400 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|119943118 cystinosis, nephropathic isoform 1 [Homo sapiens] 806 0.0
gi|119943110 cystinosis, nephropathic isoform 2 [Homo sapiens] 733 0.0
gi|226505140 PQ loop repeat containing 1 isoform 3 [Homo sapiens] 34 0.20
gi|92110021 PQ loop repeat containing 2 isoform 1 [Homo sapiens] 34 0.20
gi|92110025 PQ loop repeat containing 2 isoform 1 [Homo sapiens] 34 0.20
gi|92110023 PQ loop repeat containing 2 isoform 2 [Homo sapiens] 34 0.20
gi|31542733 PQ loop repeat containing 1 isoform 1 [Homo sapiens] 34 0.27
gi|32967311 ephrin receptor EphA2 [Homo sapiens] 33 0.35
gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens] 33 0.60
gi|50083289 selenoprotein I [Homo sapiens] 31 2.3
gi|4759274 thioredoxin-like 1 [Homo sapiens] 30 3.0
gi|14270496 protocadherin gamma subfamily B, 3 isoform 2 precurs... 30 3.9
gi|11128033 protocadherin gamma subfamily B, 3 isoform 1 precurs... 30 3.9
gi|222537743 protein tyrosine phosphatase, receptor type, Q [Hom... 29 6.6
gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo s... 29 6.6
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens] 29 8.6
gi|239741714 PREDICTED: hypothetical protein XP_002342305 [Homo ... 29 8.6
gi|22547184 transient receptor potential cation channel, subfami... 29 8.6
gi|22547180 transient receptor potential cation channel, subfami... 29 8.6
>gi|119943118 cystinosis, nephropathic isoform 1 [Homo sapiens]
Length = 400
Score = 806 bits (2081), Expect = 0.0
Identities = 400/400 (100%), Positives = 400/400 (100%)
Query: 1 MIRNWLTIFILFPLKLVEKCESSVSLTVPPVVKLENGSSTNVSLTLRPPLNATLVITFEI 60
MIRNWLTIFILFPLKLVEKCESSVSLTVPPVVKLENGSSTNVSLTLRPPLNATLVITFEI
Sbjct: 1 MIRNWLTIFILFPLKLVEKCESSVSLTVPPVVKLENGSSTNVSLTLRPPLNATLVITFEI 60
Query: 61 TFRSKNITILELPDEVVVPPGVTNSSFQVTSQNVGQLTVYLHGNHSNQTGPRIRFLVIRS 120
TFRSKNITILELPDEVVVPPGVTNSSFQVTSQNVGQLTVYLHGNHSNQTGPRIRFLVIRS
Sbjct: 61 TFRSKNITILELPDEVVVPPGVTNSSFQVTSQNVGQLTVYLHGNHSNQTGPRIRFLVIRS 120
Query: 121 SAISIINQVIGWIYFVAWSISFYPQVIMNWRRKSVIGLSFDFVALNLTGFVAYSVFNIGL 180
SAISIINQVIGWIYFVAWSISFYPQVIMNWRRKSVIGLSFDFVALNLTGFVAYSVFNIGL
Sbjct: 121 SAISIINQVIGWIYFVAWSISFYPQVIMNWRRKSVIGLSFDFVALNLTGFVAYSVFNIGL 180
Query: 181 LWVPYIKEQFLLKYPNGVNPVNSNDVFFSLHAVVLTLIIIVQCCLYERGGQRVSWPAIGF 240
LWVPYIKEQFLLKYPNGVNPVNSNDVFFSLHAVVLTLIIIVQCCLYERGGQRVSWPAIGF
Sbjct: 181 LWVPYIKEQFLLKYPNGVNPVNSNDVFFSLHAVVLTLIIIVQCCLYERGGQRVSWPAIGF 240
Query: 241 LVLAWLFAFVTMIVAAVGVTTWLQFLFCFSYIKLAVTLVKYFPQAYMNFYYKSTEGWSIG 300
LVLAWLFAFVTMIVAAVGVTTWLQFLFCFSYIKLAVTLVKYFPQAYMNFYYKSTEGWSIG
Sbjct: 241 LVLAWLFAFVTMIVAAVGVTTWLQFLFCFSYIKLAVTLVKYFPQAYMNFYYKSTEGWSIG 300
Query: 301 NVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFSIVFDVVFFIQHFCLYRKR 360
NVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFSIVFDVVFFIQHFCLYRKR
Sbjct: 301 NVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFSIVFDVVFFIQHFCLYRKR 360
Query: 361 PGLQAARTGSGSRLRQDWAPSLQPKALPQTTSVSASSLKG 400
PGLQAARTGSGSRLRQDWAPSLQPKALPQTTSVSASSLKG
Sbjct: 361 PGLQAARTGSGSRLRQDWAPSLQPKALPQTTSVSASSLKG 400
>gi|119943110 cystinosis, nephropathic isoform 2 [Homo sapiens]
Length = 367
Score = 733 bits (1893), Expect = 0.0
Identities = 362/362 (100%), Positives = 362/362 (100%)
Query: 1 MIRNWLTIFILFPLKLVEKCESSVSLTVPPVVKLENGSSTNVSLTLRPPLNATLVITFEI 60
MIRNWLTIFILFPLKLVEKCESSVSLTVPPVVKLENGSSTNVSLTLRPPLNATLVITFEI
Sbjct: 1 MIRNWLTIFILFPLKLVEKCESSVSLTVPPVVKLENGSSTNVSLTLRPPLNATLVITFEI 60
Query: 61 TFRSKNITILELPDEVVVPPGVTNSSFQVTSQNVGQLTVYLHGNHSNQTGPRIRFLVIRS 120
TFRSKNITILELPDEVVVPPGVTNSSFQVTSQNVGQLTVYLHGNHSNQTGPRIRFLVIRS
Sbjct: 61 TFRSKNITILELPDEVVVPPGVTNSSFQVTSQNVGQLTVYLHGNHSNQTGPRIRFLVIRS 120
Query: 121 SAISIINQVIGWIYFVAWSISFYPQVIMNWRRKSVIGLSFDFVALNLTGFVAYSVFNIGL 180
SAISIINQVIGWIYFVAWSISFYPQVIMNWRRKSVIGLSFDFVALNLTGFVAYSVFNIGL
Sbjct: 121 SAISIINQVIGWIYFVAWSISFYPQVIMNWRRKSVIGLSFDFVALNLTGFVAYSVFNIGL 180
Query: 181 LWVPYIKEQFLLKYPNGVNPVNSNDVFFSLHAVVLTLIIIVQCCLYERGGQRVSWPAIGF 240
LWVPYIKEQFLLKYPNGVNPVNSNDVFFSLHAVVLTLIIIVQCCLYERGGQRVSWPAIGF
Sbjct: 181 LWVPYIKEQFLLKYPNGVNPVNSNDVFFSLHAVVLTLIIIVQCCLYERGGQRVSWPAIGF 240
Query: 241 LVLAWLFAFVTMIVAAVGVTTWLQFLFCFSYIKLAVTLVKYFPQAYMNFYYKSTEGWSIG 300
LVLAWLFAFVTMIVAAVGVTTWLQFLFCFSYIKLAVTLVKYFPQAYMNFYYKSTEGWSIG
Sbjct: 241 LVLAWLFAFVTMIVAAVGVTTWLQFLFCFSYIKLAVTLVKYFPQAYMNFYYKSTEGWSIG 300
Query: 301 NVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFSIVFDVVFFIQHFCLYRKR 360
NVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFSIVFDVVFFIQHFCLYRKR
Sbjct: 301 NVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFSIVFDVVFFIQHFCLYRKR 360
Query: 361 PG 362
PG
Sbjct: 361 PG 362
>gi|226505140 PQ loop repeat containing 1 isoform 3 [Homo sapiens]
Length = 253
Score = 34.3 bits (77), Expect = 0.20
Identities = 34/163 (20%), Positives = 69/163 (42%), Gaps = 28/163 (17%)
Query: 213 VVLTLIIIVQCCLYERGGQRVSWPAIGFLVLA----WLFA----FVTMIVAAVGVTTWLQ 264
++LT++++++ C R ++ F W ++ +V ++A GV ++
Sbjct: 84 MILTMLLMLKLCTEVRVANELNARRRSFTDFDPHHFWQWSSFSDYVQCVLAFTGVAGYIT 143
Query: 265 FLFCFS--------YIKLAVTLVKYFPQAYMNFYYKSTEGWSIGNVLLDFTGGSFSLLQM 316
+L S ++ + + PQ Y N ++STEG SI VL+ +G +F
Sbjct: 144 YLSIDSALFVETLGFLAVLTEAMLGVPQLYRNHRHQSTEGMSIKMVLMWTSGDAFKTAYF 203
Query: 317 FLQSYNNDQWTLIFGDPTKFGL-GVFSIVFDVVFFIQHFCLYR 358
L+ G P +F + G+ ++ D+ Q + R
Sbjct: 204 LLK-----------GAPLQFSVCGLLQVLVDLAILGQAYAFAR 235
>gi|92110021 PQ loop repeat containing 2 isoform 1 [Homo sapiens]
Length = 291
Score = 34.3 bits (77), Expect = 0.20
Identities = 19/51 (37%), Positives = 28/51 (54%)
Query: 125 IINQVIGWIYFVAWSISFYPQVIMNWRRKSVIGLSFDFVALNLTGFVAYSV 175
+I VIG I V + +S PQ+ N+ RKS G+S+ AL + G Y +
Sbjct: 182 VIGFVIGSISSVLYLLSRLPQIRTNFLRKSTQGISYSLFALVMLGNTLYGL 232
>gi|92110025 PQ loop repeat containing 2 isoform 1 [Homo sapiens]
Length = 291
Score = 34.3 bits (77), Expect = 0.20
Identities = 19/51 (37%), Positives = 28/51 (54%)
Query: 125 IINQVIGWIYFVAWSISFYPQVIMNWRRKSVIGLSFDFVALNLTGFVAYSV 175
+I VIG I V + +S PQ+ N+ RKS G+S+ AL + G Y +
Sbjct: 182 VIGFVIGSISSVLYLLSRLPQIRTNFLRKSTQGISYSLFALVMLGNTLYGL 232
>gi|92110023 PQ loop repeat containing 2 isoform 2 [Homo sapiens]
Length = 226
Score = 34.3 bits (77), Expect = 0.20
Identities = 19/51 (37%), Positives = 28/51 (54%)
Query: 125 IINQVIGWIYFVAWSISFYPQVIMNWRRKSVIGLSFDFVALNLTGFVAYSV 175
+I VIG I V + +S PQ+ N+ RKS G+S+ AL + G Y +
Sbjct: 117 VIGFVIGSISSVLYLLSRLPQIRTNFLRKSTQGISYSLFALVMLGNTLYGL 167
>gi|31542733 PQ loop repeat containing 1 isoform 1 [Homo sapiens]
Length = 271
Score = 33.9 bits (76), Expect = 0.27
Identities = 28/119 (23%), Positives = 51/119 (42%), Gaps = 20/119 (16%)
Query: 249 FVTMIVAAVGVTTWLQFLFCFS--------YIKLAVTLVKYFPQAYMNFYYKSTEGWSIG 300
+V ++A GV ++ +L S ++ + + PQ Y N ++STEG SI
Sbjct: 146 YVQCVLAFTGVAGYITYLSIDSALFVETLGFLAVLTEAMLGVPQLYRNHRHQSTEGMSIK 205
Query: 301 NVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGL-GVFSIVFDVVFFIQHFCLYR 358
VL+ +G +F L+ G P +F + G+ ++ D+ Q + R
Sbjct: 206 MVLMWTSGDAFKTAYFLLK-----------GAPLQFSVCGLLQVLVDLAILGQAYAFAR 253
>gi|32967311 ephrin receptor EphA2 [Homo sapiens]
Length = 976
Score = 33.5 bits (75), Expect = 0.35
Identities = 17/44 (38%), Positives = 29/44 (65%), Gaps = 1/44 (2%)
Query: 23 SVSLTVPPVVKLENGSSTNVSLTLR-PPLNATLVITFEITFRSK 65
S++ T PP V+LE S+T++S++ PP + V +E+T+R K
Sbjct: 433 SINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKK 476
>gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens]
Length = 1522
Score = 32.7 bits (73), Expect = 0.60
Identities = 13/30 (43%), Positives = 21/30 (70%)
Query: 309 GSFSLLQMFLQSYNNDQWTLIFGDPTKFGL 338
GS+S+ +MF +++ N WTL DPTK+ +
Sbjct: 40 GSYSVSEMFPKNFTNCTWTLENPDPTKYSI 69
>gi|50083289 selenoprotein I [Homo sapiens]
Length = 397
Score = 30.8 bits (68), Expect = 2.3
Identities = 26/92 (28%), Positives = 40/92 (43%), Gaps = 10/92 (10%)
Query: 206 VFFSLHAVVLTLIIIVQCCLYERGGQRVSWPAIGFLVLAWLFAFVTMIVAAVGVTTWLQ- 264
V + L VVL I+ Y G + W G+ + +FV ++ A VGV W +
Sbjct: 155 VLYLLLWVVLFSFILSHWEKYNTGILFLPW---GYDISQVTISFVYIVTAVVGVEAWYEP 211
Query: 265 FLFCFSYIKLAVTLV------KYFPQAYMNFY 290
FLF F Y L ++ P + +NF+
Sbjct: 212 FLFNFLYRDLFTAMIIGCALCVTLPMSLLNFF 243
>gi|4759274 thioredoxin-like 1 [Homo sapiens]
Length = 289
Score = 30.4 bits (67), Expect = 3.0
Identities = 18/78 (23%), Positives = 34/78 (43%), Gaps = 1/78 (1%)
Query: 50 LNATLVITFEITFRSKNITILELPDEVVVPPGVTNSSFQVTSQNVGQLTVYLHGNHSNQT 109
+N + FE RS+ LEL ++ + G+ + V QNV +T+++ N +
Sbjct: 198 INLPRSMDFEEAERSEPTQALELTEDDIKEDGIVPLRY-VKFQNVNSVTIFVQSNQGEEE 256
Query: 110 GPRIRFLVIRSSAISIIN 127
RI + + + N
Sbjct: 257 TTRISYFTFIGTPVQATN 274
>gi|14270496 protocadherin gamma subfamily B, 3 isoform 2 precursor
[Homo sapiens]
Length = 814
Score = 30.0 bits (66), Expect = 3.9
Identities = 21/93 (22%), Positives = 41/93 (44%), Gaps = 9/93 (9%)
Query: 12 FPLKLVEKCESSVSLTVPPVVKLENGSSTNVSLTL----RPPLNATLVITFEITFRSKNI 67
FP K+V+ +++ L + E NV++T PPL+++ IT I + N+
Sbjct: 390 FPFKIVQDTKNTYRLVTDGALDREQIPEYNVTITATDKGNPPLSSSKTITLHILDVNDNV 449
Query: 68 TILELPDEVV-----VPPGVTNSSFQVTSQNVG 95
+ V PPG + + + + ++G
Sbjct: 450 PVFHQASYTVHVAENNPPGASIAHVRASDPDLG 482
>gi|11128033 protocadherin gamma subfamily B, 3 isoform 1 precursor
[Homo sapiens]
Length = 929
Score = 30.0 bits (66), Expect = 3.9
Identities = 21/93 (22%), Positives = 41/93 (44%), Gaps = 9/93 (9%)
Query: 12 FPLKLVEKCESSVSLTVPPVVKLENGSSTNVSLTL----RPPLNATLVITFEITFRSKNI 67
FP K+V+ +++ L + E NV++T PPL+++ IT I + N+
Sbjct: 390 FPFKIVQDTKNTYRLVTDGALDREQIPEYNVTITATDKGNPPLSSSKTITLHILDVNDNV 449
Query: 68 TILELPDEVV-----VPPGVTNSSFQVTSQNVG 95
+ V PPG + + + + ++G
Sbjct: 450 PVFHQASYTVHVAENNPPGASIAHVRASDPDLG 482
>gi|222537743 protein tyrosine phosphatase, receptor type, Q [Homo
sapiens]
Length = 2299
Score = 29.3 bits (64), Expect = 6.6
Identities = 17/56 (30%), Positives = 30/56 (53%), Gaps = 1/56 (1%)
Query: 12 FPLKLVEKCESSVSLTVPPVVKLENGSSTNVSLTLRPPLNAT-LVITFEITFRSKN 66
+ +L K E V T P + +N SST+V L+ PP+ +I++++T + N
Sbjct: 1137 YTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPN 1192
>gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo
sapiens]
Length = 592
Score = 29.3 bits (64), Expect = 6.6
Identities = 32/141 (22%), Positives = 52/141 (36%), Gaps = 14/141 (9%)
Query: 150 WRRKS--VIGLSFDFVALNLTGFVAYSVFNIGLLWVPYIKEQFLLKYPNGVNPVNSNDVF 207
WR S + G+ V ++ + Y+V N W Y+ F P V P+N N
Sbjct: 77 WRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFW--YLFHSFQDPLPWSVCPLNGNHTG 134
Query: 208 F--------SLHAVVLTLIIIVQCCLYERGGQRVSWPAIGFLVLAWLFAFVTMIVAAVGV 259
+ S + + L E GG V W L+LAWL ++ ++
Sbjct: 135 YDEECEKASSTQYFWYRKTLNISPSLQENGG--VQWEPALCLLLAWLVVYLCILRGTEST 192
Query: 260 TTWLQFLFCFSYIKLAVTLVK 280
+ F Y L + L++
Sbjct: 193 GKVVYFTASLPYCVLIIYLIR 213
>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
Length = 2481
Score = 28.9 bits (63), Expect = 8.6
Identities = 19/72 (26%), Positives = 38/72 (52%), Gaps = 7/72 (9%)
Query: 27 TVPPVVKLENGSSTNVSLTLRPPLNATLVITFEITFRSKNITILELPDEVVVPPGVTNSS 86
T+P +++++ +S S++ PPL E+ + ++ L+LP ++VV S+
Sbjct: 1578 TIPESLRVQDDASDGESISDCPPLQ-------ELLLTAADVLDLQLPVKLVVLGSSQESN 1630
Query: 87 FQVTSQNVGQLT 98
+VT+ V LT
Sbjct: 1631 SKVTADGVIALT 1642
>gi|239741714 PREDICTED: hypothetical protein XP_002342305 [Homo
sapiens]
Length = 231
Score = 28.9 bits (63), Expect = 8.6
Identities = 26/103 (25%), Positives = 46/103 (44%), Gaps = 8/103 (7%)
Query: 217 LIIIVQCCLYERGGQRVSWPAIGFLVLAWLFAFVTMIVAAVGVTTWLQFLFCFSYIKLAV 276
L +V C + G + + GFLV W T IV + + W+ ++ S++ +
Sbjct: 94 LAAVVSCLRPQPGEEPQTHEIFGFLV--WTMVAATHIVYPL-LQGWVMYVSLTSFL---I 147
Query: 277 TLVKYFPQAYMNFYYKSTEGWSIGNVLLDFTGGSFSLLQMFLQ 319
+L+ F +Y+ +YK E W + + L T G + LQ
Sbjct: 148 SLM--FLLSYLFGFYKRFESWRVLDSLYHGTTGILYMSAAVLQ 188
>gi|22547184 transient receptor potential cation channel, subfamily
V, member 4 isoform a [Homo sapiens]
Length = 871
Score = 28.9 bits (63), Expect = 8.6
Identities = 27/84 (32%), Positives = 41/84 (48%), Gaps = 3/84 (3%)
Query: 165 LNLTGFVAYSVFNIGLLWVPYIKEQFLLKYPNGVNPVNSNDVFFSLHAVVLTLIIIVQCC 224
L L G V ++F L + IK+ F+ K P GVN + D F L + ++++IV
Sbjct: 509 LRLAGEVI-TLFTGVLFFFTNIKDLFMKKCP-GVNSLFI-DGSFQLLYFIYSVLVIVSAA 565
Query: 225 LYERGGQRVSWPAIGFLVLAWLFA 248
LY G + + LVL W+ A
Sbjct: 566 LYLAGIEAYLAVMVFALVLGWMNA 589
>gi|22547180 transient receptor potential cation channel, subfamily
V, member 4 isoform b [Homo sapiens]
Length = 811
Score = 28.9 bits (63), Expect = 8.6
Identities = 27/84 (32%), Positives = 41/84 (48%), Gaps = 3/84 (3%)
Query: 165 LNLTGFVAYSVFNIGLLWVPYIKEQFLLKYPNGVNPVNSNDVFFSLHAVVLTLIIIVQCC 224
L L G V ++F L + IK+ F+ K P GVN + D F L + ++++IV
Sbjct: 449 LRLAGEVI-TLFTGVLFFFTNIKDLFMKKCP-GVNSLFI-DGSFQLLYFIYSVLVIVSAA 505
Query: 225 LYERGGQRVSWPAIGFLVLAWLFA 248
LY G + + LVL W+ A
Sbjct: 506 LYLAGIEAYLAVMVFALVLGWMNA 529
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.327 0.140 0.439
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,338,562
Number of Sequences: 37866
Number of extensions: 577281
Number of successful extensions: 1740
Number of sequences better than 10.0: 19
Number of HSP's better than 10.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 1721
Number of HSP's gapped (non-prelim): 27
length of query: 400
length of database: 18,247,518
effective HSP length: 104
effective length of query: 296
effective length of database: 14,309,454
effective search space: 4235598384
effective search space used: 4235598384
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.