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Search of human proteins with 11968148
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11968148 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 2 [Homo sapiens]
(1116 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11968148 solute carrier family 12 (potassium-chloride transpo... 2256 0.0
gi|198041678 solute carrier family 12 (potassium-chloride transp... 2219 0.0
gi|123701900 solute carrier family 12 (potassium/chloride transp... 1586 0.0
gi|110224458 solute carrier family 12, member 6 isoform e [Homo ... 1555 0.0
gi|110224456 solute carrier family 12, member 6 isoform d [Homo ... 1555 0.0
gi|110224454 solute carrier family 12, member 6 isoform c [Homo ... 1555 0.0
gi|110224452 solute carrier family 12, member 6 isoform c [Homo ... 1555 0.0
gi|4826780 solute carrier family 12, member 6 isoform b [Homo sa... 1555 0.0
gi|110224449 solute carrier family 12, member 6 isoform a [Homo ... 1555 0.0
gi|225579067 solute carrier family 12, member 4 isoform e [Homo ... 1509 0.0
gi|225579065 solute carrier family 12, member 4 isoform d [Homo ... 1506 0.0
gi|4827006 solute carrier family 12, member 4 isoform a [Homo sa... 1506 0.0
gi|225579061 solute carrier family 12, member 4 isoform b [Homo ... 1489 0.0
gi|225579063 solute carrier family 12, member 4 isoform c [Homo ... 1473 0.0
gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo ... 225 2e-58
gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo ... 222 2e-57
gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo ... 222 2e-57
gi|4506975 solute carrier family 12 (sodium/potassium/chloride t... 221 3e-57
gi|134254459 sodium potassium chloride cotransporter 2 [Homo sap... 213 1e-54
gi|31881740 solute carrier family 12 (potassium/chloride transpo... 193 9e-49
gi|38569457 solute carrier family 12, member 8 [Homo sapiens] 100 8e-21
gi|33286430 solute carrier family 7 (cationic amino acid transpo... 45 5e-04
gi|33286428 solute carrier family 7 (cationic amino acid transpo... 45 5e-04
gi|195976805 hypoxia up-regulated 1 precursor [Homo sapiens] 42 0.003
gi|5453832 hypoxia up-regulated 1 precursor [Homo sapiens] 42 0.003
gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo s... 40 0.012
gi|187423910 solute carrier family 7, member 9 [Homo sapiens] 39 0.027
gi|7657591 solute carrier family 7, member 9 [Homo sapiens] 39 0.027
gi|56676330 HP1-BP74 [Homo sapiens] 39 0.036
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 38 0.061
>gi|11968148 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 2 [Homo sapiens]
Length = 1116
Score = 2256 bits (5847), Expect = 0.0
Identities = 1116/1116 (100%), Positives = 1116/1116 (100%)
Query: 1 MLNNLTDCEDGDGGANPGDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSS 60
MLNNLTDCEDGDGGANPGDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSS
Sbjct: 1 MLNNLTDCEDGDGGANPGDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSS 60
Query: 61 LLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRL 120
LLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRL
Sbjct: 61 LLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRL 120
Query: 121 TWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAV 180
TWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAV
Sbjct: 121 TWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAV 180
Query: 181 GLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTC 240
GLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTC
Sbjct: 181 GLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTC 240
Query: 241 MATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFD 300
MATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFD
Sbjct: 241 MATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFD 300
Query: 301 VCAKLAWEGNETVTTRLWGLFCSSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWS 360
VCAKLAWEGNETVTTRLWGLFCSSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWS
Sbjct: 301 VCAKLAWEGNETVTTRLWGLFCSSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWS 360
Query: 361 SYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNR 420
SYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNR
Sbjct: 361 SYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNR 420
Query: 421 SGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLA 480
SGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLA
Sbjct: 421 SGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLA 480
Query: 481 WPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLL 540
WPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLL
Sbjct: 481 WPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLL 540
Query: 541 TACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSF 600
TACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSF
Sbjct: 541 TACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSF 600
Query: 601 LGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRL 660
LGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRL
Sbjct: 601 LGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRL 660
Query: 661 EEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHP 720
EEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHP
Sbjct: 661 EEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHP 720
Query: 721 QAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWR 780
QAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWR
Sbjct: 721 QAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWR 780
Query: 781 QKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLML 840
QKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLML
Sbjct: 781 QKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLML 840
Query: 841 LPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISA 900
LPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISA
Sbjct: 841 LPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISA 900
Query: 901 YTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETA 960
YTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETA
Sbjct: 901 YTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETA 960
Query: 961 GDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKG 1020
GDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKG
Sbjct: 961 GDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKG 1020
Query: 1021 PSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRN 1080
PSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRN
Sbjct: 1021 PSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRN 1080
Query: 1081 RNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS 1116
RNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS
Sbjct: 1081 RNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS 1116
>gi|198041678 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 1 [Homo sapiens]
Length = 1139
Score = 2219 bits (5750), Expect = 0.0
Identities = 1099/1099 (100%), Positives = 1099/1099 (100%)
Query: 18 GDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSRE 77
GDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSRE
Sbjct: 41 GDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSRE 100
Query: 78 HEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVF 137
HEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVF
Sbjct: 101 HEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVF 160
Query: 138 ICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYIL 197
ICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYIL
Sbjct: 161 ICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYIL 220
Query: 198 GTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFAL 257
GTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFAL
Sbjct: 221 GTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFAL 280
Query: 258 VFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRL 317
VFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRL
Sbjct: 281 VFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRL 340
Query: 318 WGLFCSSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSV 377
WGLFCSSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSV
Sbjct: 341 WGLFCSSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSV 400
Query: 378 GLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTIL 437
GLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTIL
Sbjct: 401 GLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTIL 460
Query: 438 AIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCG 497
AIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCG
Sbjct: 461 AIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCG 520
Query: 498 AGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEV 557
AGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEV
Sbjct: 521 AGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEV 580
Query: 558 APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYY 617
APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYY
Sbjct: 581 APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYY 640
Query: 618 ALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVL 677
ALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVL
Sbjct: 641 ALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVL 700
Query: 678 VRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEK 737
VRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEK
Sbjct: 701 VRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEK 760
Query: 738 VKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRE 797
VKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRE
Sbjct: 761 VKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRE 820
Query: 798 TTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMR 857
TTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMR
Sbjct: 821 TTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMR 880
Query: 858 IFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILK 917
IFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILK
Sbjct: 881 IFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILK 940
Query: 918 QMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQ 977
QMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQ
Sbjct: 941 QMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQ 1000
Query: 978 SAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKP 1037
SAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKP
Sbjct: 1001 SAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKP 1060
Query: 1038 EWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEH 1097
EWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEH
Sbjct: 1061 EWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEH 1120
Query: 1098 LDRVMLVRGGGREVITIYS 1116
LDRVMLVRGGGREVITIYS
Sbjct: 1121 LDRVMLVRGGGREVITIYS 1139
>gi|123701900 solute carrier family 12 (potassium/chloride
transporters), member 7 [Homo sapiens]
Length = 1083
Score = 1586 bits (4106), Expect = 0.0
Identities = 792/1101 (71%), Positives = 906/1101 (82%), Gaps = 57/1101 (5%)
Query: 16 NPGDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGS 75
+PGDGNP+E+SPF+N+ + E+ ++GKNMALFEEEMD++PMVSSLL+ LANYTNL QG
Sbjct: 40 SPGDGNPRENSPFLNNVEVEQESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGV 99
Query: 76 REHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCM 135
EHEE E + +++ +APRMGTF+GVYLPCLQNI GVILFLRLTW+VG+AG++ESF +
Sbjct: 100 VEHEEDEES---RRREAKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLI 156
Query: 136 VFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMY 195
V +CC+CTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMY
Sbjct: 157 VAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMY 216
Query: 196 ILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKF 255
ILGTIEI L Y+ P AIF+AE A GEAAAML+NMRVYGTC L MA VVFVGVKYVNK
Sbjct: 217 ILGTIEIFLTYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKL 276
Query: 256 ALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTT 315
ALVFL CV+LSILAIYAGVIKSAFDPP+ P+CLLGNRTLSR FD C K N + T+
Sbjct: 277 ALVFLACVVLSILAIYAGVIKSAFDPPDIPVCLLGNRTLSRRSFDACVKAYGIHNNSATS 336
Query: 316 RLWGLFCSSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMT 375
LWGLFC+ +A CDEYF +NNVTEIQGIPGAASG+ ENLWS+Y G VE+ G+
Sbjct: 337 ALWGLFCNGSQPSAACDEYFIQNNVTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVP 396
Query: 376 SVGLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGT 435
SV +A+ + PYV +D+ + FTLLVGIYFPSVTGIMAGSNRSGDL+DAQKSIPTGT
Sbjct: 397 SVPVAEESRASA-LPYVLTDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGT 455
Query: 436 ILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFST 495
ILAI TTS +Y+S +VLFGACIEGVVLRDKFGEA+ GNLV+G LAWPSPWVIVIGSFFST
Sbjct: 456 ILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFST 515
Query: 496 CGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLD 555
CGAGLQSLTGAPRLLQAI+RDGIVPFLQVFGHGKANGEPTWALLLT ICE GILIASLD
Sbjct: 516 CGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLTVLICETGILIASLD 575
Query: 556 EVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSW 615
VAPILSMFFLMCY+FVNLACAVQTLLRTPNWRPRF++YHWTLSFLGMSLCLALMFICSW
Sbjct: 576 SVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSW 635
Query: 616 YYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLL 675
YYAL AMLIAG IYKYIEYRGAEKEWGDGIRGLSL+AARYALLR+E GPPHTKNWRPQ+L
Sbjct: 636 YYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVL 695
Query: 676 VLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEA 735
V++ +D +Q V HP+LLS TSQLKAGKGLTIVGSVLEGT+L+ H +AQRAEE+IR LM
Sbjct: 696 VMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMST 755
Query: 736 EKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELV 795
EK KGFCQ+V+SS+LRDG+SHLIQS GLGGL+HNTVL+ WP +W+Q+++ +W+NF++ V
Sbjct: 756 EKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTV 815
Query: 796 RETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCK 855
R+TTA H ALLV KNV FP N ERF G IDVWWIVHDGGMLMLLPFLLR HKVWRKC+
Sbjct: 816 RDTTAAHQALLVAKNVDSFPQNQERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCR 875
Query: 856 MRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQI 915
MRIFTVAQ+DDNSIQMKKDL FLYHLRI+AEVEVVEM E+DISA+TYE+TL+MEQRSQ+
Sbjct: 876 MRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYERTLMMEQRSQM 935
Query: 916 LKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIH 975
LKQM L+KNE+ERE Q LIH
Sbjct: 936 LKQMQLSKNEQEREAQ-----------------------------------------LIH 954
Query: 976 DQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSM 1035
D++ S +++ P P+KV +TWT++K +AEK + S G KD FSM
Sbjct: 955 DRNTASHTAAAARTQAPP------TPDKVQMTWTREKLIAEKYRS-RDTSLSGFKDLFSM 1007
Query: 1036 KPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLT 1095
KP+ QSNVRRMHTAV+LN V++ KS+DA+LVLLNMPGPP+NR GDENYMEFLEVLT
Sbjct: 1008 KPD-----QSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLT 1062
Query: 1096 EHLDRVMLVRGGGREVITIYS 1116
E L+RV+LVRGGGREVITIYS
Sbjct: 1063 EGLNRVLLVRGGGREVITIYS 1083
>gi|110224458 solute carrier family 12, member 6 isoform e [Homo
sapiens]
Length = 1135
Score = 1555 bits (4025), Expect = 0.0
Identities = 775/1099 (70%), Positives = 897/1099 (81%), Gaps = 56/1099 (5%)
Query: 19 DGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREH 78
DG+ K + ++N+++ E+G EY KN+ALFEEEMDT P VSSLL+ +ANYTNL QG++EH
Sbjct: 92 DGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEH 151
Query: 79 EEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFI 138
EEAEN GKKKP + P+MGTFMGVYLPCLQNIFGVILFLRLTWVVG AG++++F +V I
Sbjct: 152 EEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLI 211
Query: 139 CCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILG 198
CC CTMLTAISMSAIATNGVVPAGGSY+MISR+LGPEFGGAVGLCFYLGTTFA AMYILG
Sbjct: 212 CCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILG 271
Query: 199 TIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALV 258
IEI L Y+ P AIF ++DA E+AAMLNNMRVYGT L M VVF+GV+YVNKFA +
Sbjct: 272 AIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASL 331
Query: 259 FLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLW 318
FL CVI+SILAIYAG IKS+F PP+FP+C+LGNRTLS DVC+K N TV ++LW
Sbjct: 332 FLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLW 391
Query: 319 GLFC-SSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSV 377
G FC SS+F NATCDEYF NNVT IQGIPG ASG+I ENLWS+YL KG I+E+ S
Sbjct: 392 GFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSS 451
Query: 378 GLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTIL 437
+ ++H YV D+T+ FTLLVGI+FPSVTGIMAGSNRSGDL+DAQKSIP GTIL
Sbjct: 452 DVLGS----LNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTIL 507
Query: 438 AIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCG 497
AI TTS VY+S+VVLFGACIEGVVLRDKFG+AV GNLVVGTL+WPSPWVIVIGSFFSTCG
Sbjct: 508 AILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCG 567
Query: 498 AGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEV 557
AGLQSLTGAPRLLQAI++D I+PFL+VFGH KANGEPTWALLLTA I E+GILIASLD V
Sbjct: 568 AGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLV 627
Query: 558 APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYY 617
APILSMFFLMCY+FVNLACA+QTLLRTPNWRPRFRYYHW LSF+GMS+CLALMFI SWYY
Sbjct: 628 APILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYY 687
Query: 618 ALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVL 677
A+VAM+IAG+IYKYIEY+GAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHTKNWRPQLLVL
Sbjct: 688 AIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVL 747
Query: 678 VRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEK 737
+++D+D +V HP+LL+ SQLKAGKGLTIVGSV+ G FLEN+ +A AE++I+ LMEAEK
Sbjct: 748 LKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEK 807
Query: 738 VKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRE 797
VKGFCQ+V+++ LR+G+SHLIQS GLGG++HNTV++GWP WRQ ED + W+ FI VR
Sbjct: 808 VKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRV 867
Query: 798 TTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMR 857
TTA HLALLV KN+S FP N E+FSEG+IDVWWIVHDGGMLMLLPFLL+ HKVWRKC +R
Sbjct: 868 TTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIR 927
Query: 858 IFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILK 917
IFTVAQ++DNSIQMKKDL TFLYHLRI AEVEVVEMH+SDISAYTYE+TL+MEQRSQ+L+
Sbjct: 928 IFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLR 987
Query: 918 QMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQ 977
M L+K ER+RE Q + D N+ LRL
Sbjct: 988 HMRLSKTERDREAQLVKDR-----------NSMLRLT----------------------- 1013
Query: 978 SAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKP 1037
S G + + E ET EKVH+TWTKDK +A ++G S EG +D +M+P
Sbjct: 1014 ----------SIGSDEDEETETYQEKVHMTWTKDKYMA--SRGQKAKSMEGFQDLLNMRP 1061
Query: 1038 EWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEH 1097
+ QSNVRRMHTAV+LNEVIV KS +AKLVLLNMPGPPRN GDENYMEFLEVLTE
Sbjct: 1062 D-----QSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEG 1116
Query: 1098 LDRVMLVRGGGREVITIYS 1116
L+RV+LVRGGG EVITIYS
Sbjct: 1117 LERVLLVRGGGSEVITIYS 1135
>gi|110224456 solute carrier family 12, member 6 isoform d [Homo
sapiens]
Length = 1141
Score = 1555 bits (4025), Expect = 0.0
Identities = 775/1099 (70%), Positives = 897/1099 (81%), Gaps = 56/1099 (5%)
Query: 19 DGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREH 78
DG+ K + ++N+++ E+G EY KN+ALFEEEMDT P VSSLL+ +ANYTNL QG++EH
Sbjct: 98 DGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEH 157
Query: 79 EEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFI 138
EEAEN GKKKP + P+MGTFMGVYLPCLQNIFGVILFLRLTWVVG AG++++F +V I
Sbjct: 158 EEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLI 217
Query: 139 CCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILG 198
CC CTMLTAISMSAIATNGVVPAGGSY+MISR+LGPEFGGAVGLCFYLGTTFA AMYILG
Sbjct: 218 CCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILG 277
Query: 199 TIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALV 258
IEI L Y+ P AIF ++DA E+AAMLNNMRVYGT L M VVF+GV+YVNKFA +
Sbjct: 278 AIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASL 337
Query: 259 FLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLW 318
FL CVI+SILAIYAG IKS+F PP+FP+C+LGNRTLS DVC+K N TV ++LW
Sbjct: 338 FLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLW 397
Query: 319 GLFC-SSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSV 377
G FC SS+F NATCDEYF NNVT IQGIPG ASG+I ENLWS+YL KG I+E+ S
Sbjct: 398 GFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSS 457
Query: 378 GLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTIL 437
+ ++H YV D+T+ FTLLVGI+FPSVTGIMAGSNRSGDL+DAQKSIP GTIL
Sbjct: 458 DVLGS----LNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTIL 513
Query: 438 AIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCG 497
AI TTS VY+S+VVLFGACIEGVVLRDKFG+AV GNLVVGTL+WPSPWVIVIGSFFSTCG
Sbjct: 514 AILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCG 573
Query: 498 AGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEV 557
AGLQSLTGAPRLLQAI++D I+PFL+VFGH KANGEPTWALLLTA I E+GILIASLD V
Sbjct: 574 AGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLV 633
Query: 558 APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYY 617
APILSMFFLMCY+FVNLACA+QTLLRTPNWRPRFRYYHW LSF+GMS+CLALMFI SWYY
Sbjct: 634 APILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYY 693
Query: 618 ALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVL 677
A+VAM+IAG+IYKYIEY+GAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHTKNWRPQLLVL
Sbjct: 694 AIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVL 753
Query: 678 VRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEK 737
+++D+D +V HP+LL+ SQLKAGKGLTIVGSV+ G FLEN+ +A AE++I+ LMEAEK
Sbjct: 754 LKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEK 813
Query: 738 VKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRE 797
VKGFCQ+V+++ LR+G+SHLIQS GLGG++HNTV++GWP WRQ ED + W+ FI VR
Sbjct: 814 VKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRV 873
Query: 798 TTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMR 857
TTA HLALLV KN+S FP N E+FSEG+IDVWWIVHDGGMLMLLPFLL+ HKVWRKC +R
Sbjct: 874 TTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIR 933
Query: 858 IFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILK 917
IFTVAQ++DNSIQMKKDL TFLYHLRI AEVEVVEMH+SDISAYTYE+TL+MEQRSQ+L+
Sbjct: 934 IFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLR 993
Query: 918 QMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQ 977
M L+K ER+RE Q + D N+ LRL
Sbjct: 994 HMRLSKTERDREAQLVKDR-----------NSMLRLT----------------------- 1019
Query: 978 SAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKP 1037
S G + + E ET EKVH+TWTKDK +A ++G S EG +D +M+P
Sbjct: 1020 ----------SIGSDEDEETETYQEKVHMTWTKDKYMA--SRGQKAKSMEGFQDLLNMRP 1067
Query: 1038 EWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEH 1097
+ QSNVRRMHTAV+LNEVIV KS +AKLVLLNMPGPPRN GDENYMEFLEVLTE
Sbjct: 1068 D-----QSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEG 1122
Query: 1098 LDRVMLVRGGGREVITIYS 1116
L+RV+LVRGGG EVITIYS
Sbjct: 1123 LERVLLVRGGGSEVITIYS 1141
>gi|110224454 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 1555 bits (4025), Expect = 0.0
Identities = 775/1099 (70%), Positives = 897/1099 (81%), Gaps = 56/1099 (5%)
Query: 19 DGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREH 78
DG+ K + ++N+++ E+G EY KN+ALFEEEMDT P VSSLL+ +ANYTNL QG++EH
Sbjct: 48 DGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEH 107
Query: 79 EEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFI 138
EEAEN GKKKP + P+MGTFMGVYLPCLQNIFGVILFLRLTWVVG AG++++F +V I
Sbjct: 108 EEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLI 167
Query: 139 CCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILG 198
CC CTMLTAISMSAIATNGVVPAGGSY+MISR+LGPEFGGAVGLCFYLGTTFA AMYILG
Sbjct: 168 CCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILG 227
Query: 199 TIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALV 258
IEI L Y+ P AIF ++DA E+AAMLNNMRVYGT L M VVF+GV+YVNKFA +
Sbjct: 228 AIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASL 287
Query: 259 FLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLW 318
FL CVI+SILAIYAG IKS+F PP+FP+C+LGNRTLS DVC+K N TV ++LW
Sbjct: 288 FLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLW 347
Query: 319 GLFC-SSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSV 377
G FC SS+F NATCDEYF NNVT IQGIPG ASG+I ENLWS+YL KG I+E+ S
Sbjct: 348 GFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSS 407
Query: 378 GLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTIL 437
+ ++H YV D+T+ FTLLVGI+FPSVTGIMAGSNRSGDL+DAQKSIP GTIL
Sbjct: 408 DVLGS----LNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTIL 463
Query: 438 AIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCG 497
AI TTS VY+S+VVLFGACIEGVVLRDKFG+AV GNLVVGTL+WPSPWVIVIGSFFSTCG
Sbjct: 464 AILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCG 523
Query: 498 AGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEV 557
AGLQSLTGAPRLLQAI++D I+PFL+VFGH KANGEPTWALLLTA I E+GILIASLD V
Sbjct: 524 AGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLV 583
Query: 558 APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYY 617
APILSMFFLMCY+FVNLACA+QTLLRTPNWRPRFRYYHW LSF+GMS+CLALMFI SWYY
Sbjct: 584 APILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYY 643
Query: 618 ALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVL 677
A+VAM+IAG+IYKYIEY+GAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHTKNWRPQLLVL
Sbjct: 644 AIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVL 703
Query: 678 VRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEK 737
+++D+D +V HP+LL+ SQLKAGKGLTIVGSV+ G FLEN+ +A AE++I+ LMEAEK
Sbjct: 704 LKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEK 763
Query: 738 VKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRE 797
VKGFCQ+V+++ LR+G+SHLIQS GLGG++HNTV++GWP WRQ ED + W+ FI VR
Sbjct: 764 VKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRV 823
Query: 798 TTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMR 857
TTA HLALLV KN+S FP N E+FSEG+IDVWWIVHDGGMLMLLPFLL+ HKVWRKC +R
Sbjct: 824 TTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIR 883
Query: 858 IFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILK 917
IFTVAQ++DNSIQMKKDL TFLYHLRI AEVEVVEMH+SDISAYTYE+TL+MEQRSQ+L+
Sbjct: 884 IFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLR 943
Query: 918 QMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQ 977
M L+K ER+RE Q + D N+ LRL
Sbjct: 944 HMRLSKTERDREAQLVKDR-----------NSMLRLT----------------------- 969
Query: 978 SAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKP 1037
S G + + E ET EKVH+TWTKDK +A ++G S EG +D +M+P
Sbjct: 970 ----------SIGSDEDEETETYQEKVHMTWTKDKYMA--SRGQKAKSMEGFQDLLNMRP 1017
Query: 1038 EWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEH 1097
+ QSNVRRMHTAV+LNEVIV KS +AKLVLLNMPGPPRN GDENYMEFLEVLTE
Sbjct: 1018 D-----QSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEG 1072
Query: 1098 LDRVMLVRGGGREVITIYS 1116
L+RV+LVRGGG EVITIYS
Sbjct: 1073 LERVLLVRGGGSEVITIYS 1091
>gi|110224452 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 1555 bits (4025), Expect = 0.0
Identities = 775/1099 (70%), Positives = 897/1099 (81%), Gaps = 56/1099 (5%)
Query: 19 DGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREH 78
DG+ K + ++N+++ E+G EY KN+ALFEEEMDT P VSSLL+ +ANYTNL QG++EH
Sbjct: 48 DGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEH 107
Query: 79 EEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFI 138
EEAEN GKKKP + P+MGTFMGVYLPCLQNIFGVILFLRLTWVVG AG++++F +V I
Sbjct: 108 EEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLI 167
Query: 139 CCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILG 198
CC CTMLTAISMSAIATNGVVPAGGSY+MISR+LGPEFGGAVGLCFYLGTTFA AMYILG
Sbjct: 168 CCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILG 227
Query: 199 TIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALV 258
IEI L Y+ P AIF ++DA E+AAMLNNMRVYGT L M VVF+GV+YVNKFA +
Sbjct: 228 AIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASL 287
Query: 259 FLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLW 318
FL CVI+SILAIYAG IKS+F PP+FP+C+LGNRTLS DVC+K N TV ++LW
Sbjct: 288 FLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLW 347
Query: 319 GLFC-SSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSV 377
G FC SS+F NATCDEYF NNVT IQGIPG ASG+I ENLWS+YL KG I+E+ S
Sbjct: 348 GFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSS 407
Query: 378 GLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTIL 437
+ ++H YV D+T+ FTLLVGI+FPSVTGIMAGSNRSGDL+DAQKSIP GTIL
Sbjct: 408 DVLGS----LNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTIL 463
Query: 438 AIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCG 497
AI TTS VY+S+VVLFGACIEGVVLRDKFG+AV GNLVVGTL+WPSPWVIVIGSFFSTCG
Sbjct: 464 AILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCG 523
Query: 498 AGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEV 557
AGLQSLTGAPRLLQAI++D I+PFL+VFGH KANGEPTWALLLTA I E+GILIASLD V
Sbjct: 524 AGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLV 583
Query: 558 APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYY 617
APILSMFFLMCY+FVNLACA+QTLLRTPNWRPRFRYYHW LSF+GMS+CLALMFI SWYY
Sbjct: 584 APILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYY 643
Query: 618 ALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVL 677
A+VAM+IAG+IYKYIEY+GAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHTKNWRPQLLVL
Sbjct: 644 AIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVL 703
Query: 678 VRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEK 737
+++D+D +V HP+LL+ SQLKAGKGLTIVGSV+ G FLEN+ +A AE++I+ LMEAEK
Sbjct: 704 LKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEK 763
Query: 738 VKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRE 797
VKGFCQ+V+++ LR+G+SHLIQS GLGG++HNTV++GWP WRQ ED + W+ FI VR
Sbjct: 764 VKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRV 823
Query: 798 TTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMR 857
TTA HLALLV KN+S FP N E+FSEG+IDVWWIVHDGGMLMLLPFLL+ HKVWRKC +R
Sbjct: 824 TTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIR 883
Query: 858 IFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILK 917
IFTVAQ++DNSIQMKKDL TFLYHLRI AEVEVVEMH+SDISAYTYE+TL+MEQRSQ+L+
Sbjct: 884 IFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLR 943
Query: 918 QMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQ 977
M L+K ER+RE Q + D N+ LRL
Sbjct: 944 HMRLSKTERDREAQLVKDR-----------NSMLRLT----------------------- 969
Query: 978 SAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKP 1037
S G + + E ET EKVH+TWTKDK +A ++G S EG +D +M+P
Sbjct: 970 ----------SIGSDEDEETETYQEKVHMTWTKDKYMA--SRGQKAKSMEGFQDLLNMRP 1017
Query: 1038 EWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEH 1097
+ QSNVRRMHTAV+LNEVIV KS +AKLVLLNMPGPPRN GDENYMEFLEVLTE
Sbjct: 1018 D-----QSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEG 1072
Query: 1098 LDRVMLVRGGGREVITIYS 1116
L+RV+LVRGGG EVITIYS
Sbjct: 1073 LERVLLVRGGGSEVITIYS 1091
>gi|4826780 solute carrier family 12, member 6 isoform b [Homo
sapiens]
Length = 1099
Score = 1555 bits (4025), Expect = 0.0
Identities = 775/1099 (70%), Positives = 897/1099 (81%), Gaps = 56/1099 (5%)
Query: 19 DGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREH 78
DG+ K + ++N+++ E+G EY KN+ALFEEEMDT P VSSLL+ +ANYTNL QG++EH
Sbjct: 56 DGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEH 115
Query: 79 EEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFI 138
EEAEN GKKKP + P+MGTFMGVYLPCLQNIFGVILFLRLTWVVG AG++++F +V I
Sbjct: 116 EEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLI 175
Query: 139 CCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILG 198
CC CTMLTAISMSAIATNGVVPAGGSY+MISR+LGPEFGGAVGLCFYLGTTFA AMYILG
Sbjct: 176 CCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILG 235
Query: 199 TIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALV 258
IEI L Y+ P AIF ++DA E+AAMLNNMRVYGT L M VVF+GV+YVNKFA +
Sbjct: 236 AIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASL 295
Query: 259 FLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLW 318
FL CVI+SILAIYAG IKS+F PP+FP+C+LGNRTLS DVC+K N TV ++LW
Sbjct: 296 FLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLW 355
Query: 319 GLFC-SSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSV 377
G FC SS+F NATCDEYF NNVT IQGIPG ASG+I ENLWS+YL KG I+E+ S
Sbjct: 356 GFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSS 415
Query: 378 GLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTIL 437
+ ++H YV D+T+ FTLLVGI+FPSVTGIMAGSNRSGDL+DAQKSIP GTIL
Sbjct: 416 DVLGS----LNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTIL 471
Query: 438 AIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCG 497
AI TTS VY+S+VVLFGACIEGVVLRDKFG+AV GNLVVGTL+WPSPWVIVIGSFFSTCG
Sbjct: 472 AILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCG 531
Query: 498 AGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEV 557
AGLQSLTGAPRLLQAI++D I+PFL+VFGH KANGEPTWALLLTA I E+GILIASLD V
Sbjct: 532 AGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLV 591
Query: 558 APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYY 617
APILSMFFLMCY+FVNLACA+QTLLRTPNWRPRFRYYHW LSF+GMS+CLALMFI SWYY
Sbjct: 592 APILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYY 651
Query: 618 ALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVL 677
A+VAM+IAG+IYKYIEY+GAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHTKNWRPQLLVL
Sbjct: 652 AIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVL 711
Query: 678 VRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEK 737
+++D+D +V HP+LL+ SQLKAGKGLTIVGSV+ G FLEN+ +A AE++I+ LMEAEK
Sbjct: 712 LKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEK 771
Query: 738 VKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRE 797
VKGFCQ+V+++ LR+G+SHLIQS GLGG++HNTV++GWP WRQ ED + W+ FI VR
Sbjct: 772 VKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRV 831
Query: 798 TTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMR 857
TTA HLALLV KN+S FP N E+FSEG+IDVWWIVHDGGMLMLLPFLL+ HKVWRKC +R
Sbjct: 832 TTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIR 891
Query: 858 IFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILK 917
IFTVAQ++DNSIQMKKDL TFLYHLRI AEVEVVEMH+SDISAYTYE+TL+MEQRSQ+L+
Sbjct: 892 IFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLR 951
Query: 918 QMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQ 977
M L+K ER+RE Q + D N+ LRL
Sbjct: 952 HMRLSKTERDREAQLVKDR-----------NSMLRLT----------------------- 977
Query: 978 SAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKP 1037
S G + + E ET EKVH+TWTKDK +A ++G S EG +D +M+P
Sbjct: 978 ----------SIGSDEDEETETYQEKVHMTWTKDKYMA--SRGQKAKSMEGFQDLLNMRP 1025
Query: 1038 EWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEH 1097
+ QSNVRRMHTAV+LNEVIV KS +AKLVLLNMPGPPRN GDENYMEFLEVLTE
Sbjct: 1026 D-----QSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEG 1080
Query: 1098 LDRVMLVRGGGREVITIYS 1116
L+RV+LVRGGG EVITIYS
Sbjct: 1081 LERVLLVRGGGSEVITIYS 1099
>gi|110224449 solute carrier family 12, member 6 isoform a [Homo
sapiens]
Length = 1150
Score = 1555 bits (4025), Expect = 0.0
Identities = 775/1099 (70%), Positives = 897/1099 (81%), Gaps = 56/1099 (5%)
Query: 19 DGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREH 78
DG+ K + ++N+++ E+G EY KN+ALFEEEMDT P VSSLL+ +ANYTNL QG++EH
Sbjct: 107 DGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEH 166
Query: 79 EEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFI 138
EEAEN GKKKP + P+MGTFMGVYLPCLQNIFGVILFLRLTWVVG AG++++F +V I
Sbjct: 167 EEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLI 226
Query: 139 CCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILG 198
CC CTMLTAISMSAIATNGVVPAGGSY+MISR+LGPEFGGAVGLCFYLGTTFA AMYILG
Sbjct: 227 CCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILG 286
Query: 199 TIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALV 258
IEI L Y+ P AIF ++DA E+AAMLNNMRVYGT L M VVF+GV+YVNKFA +
Sbjct: 287 AIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASL 346
Query: 259 FLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLW 318
FL CVI+SILAIYAG IKS+F PP+FP+C+LGNRTLS DVC+K N TV ++LW
Sbjct: 347 FLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLW 406
Query: 319 GLFC-SSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSV 377
G FC SS+F NATCDEYF NNVT IQGIPG ASG+I ENLWS+YL KG I+E+ S
Sbjct: 407 GFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSS 466
Query: 378 GLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTIL 437
+ ++H YV D+T+ FTLLVGI+FPSVTGIMAGSNRSGDL+DAQKSIP GTIL
Sbjct: 467 DVLGS----LNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTIL 522
Query: 438 AIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCG 497
AI TTS VY+S+VVLFGACIEGVVLRDKFG+AV GNLVVGTL+WPSPWVIVIGSFFSTCG
Sbjct: 523 AILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCG 582
Query: 498 AGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEV 557
AGLQSLTGAPRLLQAI++D I+PFL+VFGH KANGEPTWALLLTA I E+GILIASLD V
Sbjct: 583 AGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLV 642
Query: 558 APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYY 617
APILSMFFLMCY+FVNLACA+QTLLRTPNWRPRFRYYHW LSF+GMS+CLALMFI SWYY
Sbjct: 643 APILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYY 702
Query: 618 ALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVL 677
A+VAM+IAG+IYKYIEY+GAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHTKNWRPQLLVL
Sbjct: 703 AIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVL 762
Query: 678 VRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEK 737
+++D+D +V HP+LL+ SQLKAGKGLTIVGSV+ G FLEN+ +A AE++I+ LMEAEK
Sbjct: 763 LKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEK 822
Query: 738 VKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRE 797
VKGFCQ+V+++ LR+G+SHLIQS GLGG++HNTV++GWP WRQ ED + W+ FI VR
Sbjct: 823 VKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRV 882
Query: 798 TTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMR 857
TTA HLALLV KN+S FP N E+FSEG+IDVWWIVHDGGMLMLLPFLL+ HKVWRKC +R
Sbjct: 883 TTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIR 942
Query: 858 IFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILK 917
IFTVAQ++DNSIQMKKDL TFLYHLRI AEVEVVEMH+SDISAYTYE+TL+MEQRSQ+L+
Sbjct: 943 IFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLR 1002
Query: 918 QMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQ 977
M L+K ER+RE Q + D N+ LRL
Sbjct: 1003 HMRLSKTERDREAQLVKDR-----------NSMLRLT----------------------- 1028
Query: 978 SAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKP 1037
S G + + E ET EKVH+TWTKDK +A ++G S EG +D +M+P
Sbjct: 1029 ----------SIGSDEDEETETYQEKVHMTWTKDKYMA--SRGQKAKSMEGFQDLLNMRP 1076
Query: 1038 EWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEH 1097
+ QSNVRRMHTAV+LNEVIV KS +AKLVLLNMPGPPRN GDENYMEFLEVLTE
Sbjct: 1077 D-----QSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEG 1131
Query: 1098 LDRVMLVRGGGREVITIYS 1116
L+RV+LVRGGG EVITIYS
Sbjct: 1132 LERVLLVRGGGSEVITIYS 1150
>gi|225579067 solute carrier family 12, member 4 isoform e [Homo
sapiens]
Length = 1054
Score = 1509 bits (3906), Expect = 0.0
Identities = 761/1103 (68%), Positives = 885/1103 (80%), Gaps = 56/1103 (5%)
Query: 16 NPGDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGS 75
+PG GN +ESSPF++ + +G +Y +N+ALFEEE+D P VSSLL L +YTNL QG+
Sbjct: 6 SPGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGA 65
Query: 76 REHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCM 135
+EHEEAE+ EG +++ +AP MGT MGVYLPCLQNIFGVILFLRLTW+VG AG++++ +
Sbjct: 66 KEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLI 125
Query: 136 VFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMY 195
V ICC CT+LTAISMSAIATNGVVPAGGSY+MISRSLGPEFGGAVGLCFYLGTTFA AMY
Sbjct: 126 VLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMY 185
Query: 196 ILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKF 255
ILG IEILL Y+ P AIF A + A LNNMRVYGT LT M VVFVGVKYVNKF
Sbjct: 186 ILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKF 245
Query: 256 ALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTT 315
A +FL CVI+SIL+IYAG IKS FDPP FP+C+LGNRTLSR FD+CAK A NETV T
Sbjct: 246 ASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVAT 305
Query: 316 RLWGLFCSSRFLNA-TCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGM 374
+LW FC S L +CD YF NNVTEI GIPGAA+G+++ENLWS+YL KG IVE+ G+
Sbjct: 306 QLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGL 365
Query: 375 TSVGLADGTPIDMDHP-YVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPT 433
S AD + P YV +D+ + FT+LVGI+FPSVTGIMAGSNRSGDLRDAQKSIP
Sbjct: 366 PS---ADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPV 422
Query: 434 GTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFF 493
GTILAI TTS VY SSVVLFGACIEGVVLRDK+G+ V+ NLVVGTLAWPSPWVIVIGSFF
Sbjct: 423 GTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFF 482
Query: 494 STCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIAS 553
STCGAGLQSLTGAPRLLQAI++D I+PFL+VFGHGK NGEPTWALLLTA I E+GILIAS
Sbjct: 483 STCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIAS 542
Query: 554 LDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFIC 613
LD VAPILSMFFLMCY+FVNLACAVQTLLRTPNWRPRF+YYHW LSFLGMSLCLALMF+
Sbjct: 543 LDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVS 602
Query: 614 SWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQ 673
SWYYALVAMLIAG+IYKYIEY+GAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQ
Sbjct: 603 SWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQ 662
Query: 674 LLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLM 733
LLVL+++D+D +V +P+LL+ SQLKAGKGLTIVGSV++G+FLE++ +AQ AE++I+ +M
Sbjct: 663 LLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMM 722
Query: 734 EAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIE 793
E EKVKGFCQVV++S +R+G++HLIQS GLGG++HN+V++GWP WRQ ED + W+ FI+
Sbjct: 723 EIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFID 782
Query: 794 LVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRK 853
VR TTA HLALLV KN++ +P N ER+ EG IDVWWIVHDGGMLMLLPFLLR HKVWRK
Sbjct: 783 TVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRK 842
Query: 854 CKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRS 913
C+MRIFTVAQMDDNSIQMKKDL FLYHLR+ AEVEVVEMH SDISAYTYE+TL+MEQRS
Sbjct: 843 CRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRS 902
Query: 914 QILKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQL 973
Q+L+QM LTK ERERE Q + D ++ LRL E D E+
Sbjct: 903 QMLRQMRLTKTEREREAQLVKDR-----------HSALRL---ESLYSDEED-------- 940
Query: 974 IHDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFF 1033
E +K+ +TWT+DK + E PS + + ++
Sbjct: 941 ----------------------ESAVGADKIQMTWTRDKYMTE-TWDPSH-APDNFRELV 976
Query: 1034 SMKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEV 1093
+KP+ QSNVRRMHTAV+LNEVIV +S DA+LVLLNMPGPPRN GDENYMEFLEV
Sbjct: 977 HIKPD-----QSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEV 1031
Query: 1094 LTEHLDRVMLVRGGGREVITIYS 1116
LTE L+RV+LVRGGGREVITIYS
Sbjct: 1032 LTEGLERVLLVRGGGREVITIYS 1054
>gi|225579065 solute carrier family 12, member 4 isoform d [Homo
sapiens]
Length = 1079
Score = 1506 bits (3898), Expect = 0.0
Identities = 760/1101 (69%), Positives = 883/1101 (80%), Gaps = 56/1101 (5%)
Query: 18 GDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSRE 77
G GN +ESSPF++ + +G +Y +N+ALFEEE+D P VSSLL L +YTNL QG++E
Sbjct: 33 GHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKE 92
Query: 78 HEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVF 137
HEEAE+ EG +++ +AP MGT MGVYLPCLQNIFGVILFLRLTW+VG AG++++ +V
Sbjct: 93 HEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVL 152
Query: 138 ICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYIL 197
ICC CT+LTAISMSAIATNGVVPAGGSY+MISRSLGPEFGGAVGLCFYLGTTFA AMYIL
Sbjct: 153 ICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYIL 212
Query: 198 GTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFAL 257
G IEILL Y+ P AIF A + A LNNMRVYGT LT M VVFVGVKYVNKFA
Sbjct: 213 GAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFAS 272
Query: 258 VFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRL 317
+FL CVI+SIL+IYAG IKS FDPP FP+C+LGNRTLSR FD+CAK A NETV T+L
Sbjct: 273 LFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQL 332
Query: 318 WGLFCSSRFLNA-TCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTS 376
W FC S L +CD YF NNVTEI GIPGAA+G+++ENLWS+YL KG IVE+ G+ S
Sbjct: 333 WSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPS 392
Query: 377 VGLADGTPIDMDHP-YVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGT 435
AD + P YV +D+ + FT+LVGI+FPSVTGIMAGSNRSGDLRDAQKSIP GT
Sbjct: 393 ---ADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGT 449
Query: 436 ILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFST 495
ILAI TTS VY SSVVLFGACIEGVVLRDK+G+ V+ NLVVGTLAWPSPWVIVIGSFFST
Sbjct: 450 ILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFST 509
Query: 496 CGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLD 555
CGAGLQSLTGAPRLLQAI++D I+PFL+VFGHGK NGEPTWALLLTA I E+GILIASLD
Sbjct: 510 CGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLD 569
Query: 556 EVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSW 615
VAPILSMFFLMCY+FVNLACAVQTLLRTPNWRPRF+YYHW LSFLGMSLCLALMF+ SW
Sbjct: 570 MVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSW 629
Query: 616 YYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLL 675
YYALVAMLIAG+IYKYIEY+GAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLL
Sbjct: 630 YYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLL 689
Query: 676 VLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEA 735
VL+++D+D +V +P+LL+ SQLKAGKGLTIVGSV++G+FLE++ +AQ AE++I+ +ME
Sbjct: 690 VLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEI 749
Query: 736 EKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELV 795
EKVKGFCQVV++S +R+G++HLIQS GLGG++HN+V++GWP WRQ ED + W+ FI+ V
Sbjct: 750 EKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTV 809
Query: 796 RETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCK 855
R TTA HLALLV KN++ +P N ER+ EG IDVWWIVHDGGMLMLLPFLLR HKVWRKC+
Sbjct: 810 RCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCR 869
Query: 856 MRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQI 915
MRIFTVAQMDDNSIQMKKDL FLYHLR+ AEVEVVEMH SDISAYTYE+TL+MEQRSQ+
Sbjct: 870 MRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQM 929
Query: 916 LKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIH 975
L+QM LTK ERERE Q + D ++ LRL E D E+
Sbjct: 930 LRQMRLTKTEREREAQLVKDR-----------HSALRL---ESLYSDEED---------- 965
Query: 976 DQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSM 1035
E +K+ +TWT+DK + E PS + + ++ +
Sbjct: 966 --------------------ESAVGADKIQMTWTRDKYMTE-TWDPSH-APDNFRELVHI 1003
Query: 1036 KPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLT 1095
KP+ QSNVRRMHTAV+LNEVIV +S DA+LVLLNMPGPPRN GDENYMEFLEVLT
Sbjct: 1004 KPD-----QSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLT 1058
Query: 1096 EHLDRVMLVRGGGREVITIYS 1116
E L+RV+LVRGGGREVITIYS
Sbjct: 1059 EGLERVLLVRGGGREVITIYS 1079
>gi|4827006 solute carrier family 12, member 4 isoform a [Homo
sapiens]
Length = 1085
Score = 1506 bits (3898), Expect = 0.0
Identities = 760/1101 (69%), Positives = 883/1101 (80%), Gaps = 56/1101 (5%)
Query: 18 GDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSRE 77
G GN +ESSPF++ + +G +Y +N+ALFEEE+D P VSSLL L +YTNL QG++E
Sbjct: 39 GHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKE 98
Query: 78 HEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVF 137
HEEAE+ EG +++ +AP MGT MGVYLPCLQNIFGVILFLRLTW+VG AG++++ +V
Sbjct: 99 HEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVL 158
Query: 138 ICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYIL 197
ICC CT+LTAISMSAIATNGVVPAGGSY+MISRSLGPEFGGAVGLCFYLGTTFA AMYIL
Sbjct: 159 ICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYIL 218
Query: 198 GTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFAL 257
G IEILL Y+ P AIF A + A LNNMRVYGT LT M VVFVGVKYVNKFA
Sbjct: 219 GAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFAS 278
Query: 258 VFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRL 317
+FL CVI+SIL+IYAG IKS FDPP FP+C+LGNRTLSR FD+CAK A NETV T+L
Sbjct: 279 LFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQL 338
Query: 318 WGLFCSSRFLNA-TCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTS 376
W FC S L +CD YF NNVTEI GIPGAA+G+++ENLWS+YL KG IVE+ G+ S
Sbjct: 339 WSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPS 398
Query: 377 VGLADGTPIDMDHP-YVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGT 435
AD + P YV +D+ + FT+LVGI+FPSVTGIMAGSNRSGDLRDAQKSIP GT
Sbjct: 399 ---ADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGT 455
Query: 436 ILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFST 495
ILAI TTS VY SSVVLFGACIEGVVLRDK+G+ V+ NLVVGTLAWPSPWVIVIGSFFST
Sbjct: 456 ILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFST 515
Query: 496 CGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLD 555
CGAGLQSLTGAPRLLQAI++D I+PFL+VFGHGK NGEPTWALLLTA I E+GILIASLD
Sbjct: 516 CGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLD 575
Query: 556 EVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSW 615
VAPILSMFFLMCY+FVNLACAVQTLLRTPNWRPRF+YYHW LSFLGMSLCLALMF+ SW
Sbjct: 576 MVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSW 635
Query: 616 YYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLL 675
YYALVAMLIAG+IYKYIEY+GAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLL
Sbjct: 636 YYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLL 695
Query: 676 VLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEA 735
VL+++D+D +V +P+LL+ SQLKAGKGLTIVGSV++G+FLE++ +AQ AE++I+ +ME
Sbjct: 696 VLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEI 755
Query: 736 EKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELV 795
EKVKGFCQVV++S +R+G++HLIQS GLGG++HN+V++GWP WRQ ED + W+ FI+ V
Sbjct: 756 EKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTV 815
Query: 796 RETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCK 855
R TTA HLALLV KN++ +P N ER+ EG IDVWWIVHDGGMLMLLPFLLR HKVWRKC+
Sbjct: 816 RCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCR 875
Query: 856 MRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQI 915
MRIFTVAQMDDNSIQMKKDL FLYHLR+ AEVEVVEMH SDISAYTYE+TL+MEQRSQ+
Sbjct: 876 MRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQM 935
Query: 916 LKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIH 975
L+QM LTK ERERE Q + D ++ LRL E D E+
Sbjct: 936 LRQMRLTKTEREREAQLVKDR-----------HSALRL---ESLYSDEED---------- 971
Query: 976 DQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSM 1035
E +K+ +TWT+DK + E PS + + ++ +
Sbjct: 972 --------------------ESAVGADKIQMTWTRDKYMTE-TWDPSH-APDNFRELVHI 1009
Query: 1036 KPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLT 1095
KP+ QSNVRRMHTAV+LNEVIV +S DA+LVLLNMPGPPRN GDENYMEFLEVLT
Sbjct: 1010 KPD-----QSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLT 1064
Query: 1096 EHLDRVMLVRGGGREVITIYS 1116
E L+RV+LVRGGGREVITIYS
Sbjct: 1065 EGLERVLLVRGGGREVITIYS 1085
>gi|225579061 solute carrier family 12, member 4 isoform b [Homo
sapiens]
Length = 1079
Score = 1489 bits (3854), Expect = 0.0
Identities = 754/1101 (68%), Positives = 877/1101 (79%), Gaps = 62/1101 (5%)
Query: 18 GDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSRE 77
G GN +ESSPF++ + +G +Y +N+ALFEEE+D P VSSLL L +YTNL QG++E
Sbjct: 39 GHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKE 98
Query: 78 HEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVF 137
HEEAE+ EG +++ +AP MGT MGVYLPCLQNIFGVILFLRLTW+VG AG++++ +V
Sbjct: 99 HEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVL 158
Query: 138 ICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYIL 197
ICC CT+LTAISMSAIATNGVVPAGGSY+MISRSLGPEFGGAVGLCFYLGTTFA AMYIL
Sbjct: 159 ICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYIL 218
Query: 198 GTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFAL 257
G IEILL Y+ P AIF A + A LNNMRVYGT LT M VVFVGVKYVNKFA
Sbjct: 219 GAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFAS 278
Query: 258 VFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRL 317
+FL CVI+SIL+IYAG IKS FDPP FP+C+LGNRTLSR FD+CAK A NETV T+L
Sbjct: 279 LFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQL 338
Query: 318 WGLFCSSRFLNA-TCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTS 376
W FC S L +CD YF NNVTEI GIPGAA+G+++ENLWS+YL KG IVE+ G+ S
Sbjct: 339 WSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPS 398
Query: 377 VGLADGTPIDMDHP-YVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGT 435
AD + P YV +D+ + FT+LVGI+FPSVTGIMAGSNRSGDLRDAQKSIP GT
Sbjct: 399 ---ADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGT 455
Query: 436 ILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFST 495
ILAI TTS VY SSVVLFGACIEGVVLRDK+G+ V+ NLVVGTLAWPSPWVIVIGSFFST
Sbjct: 456 ILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFST 515
Query: 496 CGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLD 555
CGAGLQSLTGAPRLLQAI++D I+PFL+VFGHGK NGEPTWALLLTA I E+GILIASLD
Sbjct: 516 CGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLD 575
Query: 556 EVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSW 615
VAPILSMFFLMCY+FVNLACAVQTLLRTPNWRPRF+YYHW LSFLGMSLCLALMF+ SW
Sbjct: 576 MVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSW 635
Query: 616 YYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLL 675
YYALVAMLIAG+IYKYIEY+GAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLL
Sbjct: 636 YYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLL 695
Query: 676 VLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEA 735
VL+++D+D +V +P+LL+ SQLKAGKGLTIVGSV++G+FLE++ +AQ AE++I+ +ME
Sbjct: 696 VLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEI 755
Query: 736 EKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELV 795
EKVKGFCQVV++S +R+G++HLIQS GLGG++HN+V++GWP WRQ ED + W+ FI+ V
Sbjct: 756 EKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTV 815
Query: 796 RETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCK 855
R TTA HLALLV KN++ +P N ER+ EG IDVWWIVHDGGMLMLLPFLLR HKVWRKC+
Sbjct: 816 RCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCR 875
Query: 856 MRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQI 915
MRIFTVAQMDDNSIQMKKDL FLYHLR+ AE H SDISAYTYE+TL+MEQRSQ+
Sbjct: 876 MRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAE------HNSDISAYTYERTLMMEQRSQM 929
Query: 916 LKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIH 975
L+QM LTK ERERE Q + D ++ LRL E D E+
Sbjct: 930 LRQMRLTKTEREREAQLVKDR-----------HSALRL---ESLYSDEED---------- 965
Query: 976 DQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSM 1035
E +K+ +TWT+DK + E PS + + ++ +
Sbjct: 966 --------------------ESAVGADKIQMTWTRDKYMTE-TWDPSH-APDNFRELVHI 1003
Query: 1036 KPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLT 1095
KP+ QSNVRRMHTAV+LNEVIV +S DA+LVLLNMPGPPRN GDENYMEFLEVLT
Sbjct: 1004 KPD-----QSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLT 1058
Query: 1096 EHLDRVMLVRGGGREVITIYS 1116
E L+RV+LVRGGGREVITIYS
Sbjct: 1059 EGLERVLLVRGGGREVITIYS 1079
>gi|225579063 solute carrier family 12, member 4 isoform c [Homo
sapiens]
Length = 1087
Score = 1473 bits (3813), Expect = 0.0
Identities = 745/1069 (69%), Positives = 860/1069 (80%), Gaps = 56/1069 (5%)
Query: 50 EEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQ 109
EE+D P VSSLL L +YTNL QG++EHEEAE+ EG +++ +AP MGT MGVYLPCLQ
Sbjct: 73 EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ 132
Query: 110 NIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMIS 169
NIFGVILFLRLTW+VG AG++++ +V ICC CT+LTAISMSAIATNGVVPAGGSY+MIS
Sbjct: 133 NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS 192
Query: 170 RSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNN 229
RSLGPEFGGAVGLCFYLGTTFA AMYILG IEILL Y+ P AIF A + A LNN
Sbjct: 193 RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN 252
Query: 230 MRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLL 289
MRVYGT LT M VVFVGVKYVNKFA +FL CVI+SIL+IYAG IKS FDPP FP+C+L
Sbjct: 253 MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML 312
Query: 290 GNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNA-TCDEYFTRNNVTEIQGIPG 348
GNRTLSR FD+CAK A NETV T+LW FC S L +CD YF NNVTEI GIPG
Sbjct: 313 GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 372
Query: 349 AASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHP-YVFSDMTSYFTLLVGIY 407
AA+G+++ENLWS+YL KG IVE+ G+ S AD + P YV +D+ + FT+LVGI+
Sbjct: 373 AAAGVLQENLWSAYLEKGDIVEKHGLPS---ADAPSLKESLPLYVVADIATSFTVLVGIF 429
Query: 408 FPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFG 467
FPSVTGIMAGSNRSGDLRDAQKSIP GTILAI TTS VY SSVVLFGACIEGVVLRDK+G
Sbjct: 430 FPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYG 489
Query: 468 EAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGH 527
+ V+ NLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAI++D I+PFL+VFGH
Sbjct: 490 DGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGH 549
Query: 528 GKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNW 587
GK NGEPTWALLLTA I E+GILIASLD VAPILSMFFLMCY+FVNLACAVQTLLRTPNW
Sbjct: 550 GKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNW 609
Query: 588 RPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRG 647
RPRF+YYHW LSFLGMSLCLALMF+ SWYYALVAMLIAG+IYKYIEY+GAEKEWGDGIRG
Sbjct: 610 RPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRG 669
Query: 648 LSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIV 707
LSLSAARYALLRLEEGPPHTKNWRPQLLVL+++D+D +V +P+LL+ SQLKAGKGLTIV
Sbjct: 670 LSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIV 729
Query: 708 GSVLEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQ 767
GSV++G+FLE++ +AQ AE++I+ +ME EKVKGFCQVV++S +R+G++HLIQS GLGG++
Sbjct: 730 GSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMR 789
Query: 768 HNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSID 827
HN+V++GWP WRQ ED + W+ FI+ VR TTA HLALLV KN++ +P N ER+ EG ID
Sbjct: 790 HNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHID 849
Query: 828 VWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAE 887
VWWIVHDGGMLMLLPFLLR HKVWRKC+MRIFTVAQMDDNSIQMKKDL FLYHLR+ AE
Sbjct: 850 VWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAE 909
Query: 888 VEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPA 947
VEVVEMH SDISAYTYE+TL+MEQRSQ+L+QM LTK ERERE Q + D
Sbjct: 910 VEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDR----------- 958
Query: 948 NTRLRLNVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLT 1007
++ LRL E D E+ E +K+ +T
Sbjct: 959 HSALRL---ESLYSDEED------------------------------ESAVGADKIQMT 985
Query: 1008 WTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDA 1067
WT+DK + E PS + + ++ +KP+ QSNVRRMHTAV+LNEVIV +S DA
Sbjct: 986 WTRDKYMTE-TWDPSH-APDNFRELVHIKPD-----QSNVRRMHTAVKLNEVIVTRSHDA 1038
Query: 1068 KLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS 1116
+LVLLNMPGPPRN GDENYMEFLEVLTE L+RV+LVRGGGREVITIYS
Sbjct: 1039 RLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1087
>gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo
sapiens]
Length = 1021
Score = 225 bits (573), Expect = 2e-58
Identities = 161/557 (28%), Positives = 253/557 (45%), Gaps = 86/557 (15%)
Query: 403 LVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVL 462
+ I+FPS TGI+AG+N SGDL+D +IP GT++AI T+ Y++ G+C V+
Sbjct: 343 MFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC----VV 398
Query: 463 RDKFGEAVNGNLVVGT-----LAWPSPW------------------------------VI 487
RD G +N + G LA W +I
Sbjct: 399 RDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLI 457
Query: 488 VIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKA-NGEPTWALLLTACICE 546
G F +T + L L A ++ Q + D + P + FG G N EP LL I
Sbjct: 458 TAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAV 517
Query: 547 IGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLC 606
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G +
Sbjct: 518 AFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIIS 577
Query: 607 LALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPH 666
+ +MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 578 VVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDH 637
Query: 667 TKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAE 726
KN+RPQ LVL P L+ L I G VL G + P+ Q
Sbjct: 638 IKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIA 693
Query: 727 ESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQ 786
+ + K+K F VI+ +LR GV L+Q+ GLG ++ N ++VG+ +NW Q
Sbjct: 694 NGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPA 752
Query: 787 TWRNFIELVRETTAGHLALLVTK-----NVSMFPG---NP-----ERFSEGS-------- 825
T ++I ++ + + + V + NVS NP E E S
Sbjct: 753 TVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARVDPKAL 812
Query: 826 ------------------IDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDN 867
ID++W+ DGG+ +L+P+LL + W KCK+R+F Q+ +
Sbjct: 813 VKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQI-NR 871
Query: 868 SIQMKKDLTTFLYHLRI 884
Q +K + + L R+
Sbjct: 872 MDQERKAIISLLSKFRL 888
Score = 120 bits (302), Expect = 5e-27
Identities = 65/204 (31%), Positives = 111/204 (54%), Gaps = 13/204 (6%)
Query: 80 EAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFIC 139
E E +K P + R G GV + C+ NI+GVIL+LRL W+ AGI+ ++ ++ +
Sbjct: 119 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 178
Query: 140 CSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGT 199
+ T +T +S+SAI+TNG V +GG+Y++ISRSLGPE GG++GL F AM+ +G
Sbjct: 179 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 238
Query: 200 IEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVF 259
E + L ++ +N++R+ G +T + + G+++ +K ++F
Sbjct: 239 AETVRDLL---------QEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLF 289
Query: 260 LGCVILSILAIYAGVIKSAFDPPN 283
L I+ +A + PP+
Sbjct: 290 ----FLVIMVSFANYLVGTLIPPS 309
Score = 47.4 bits (111), Expect = 8e-05
Identities = 26/77 (33%), Positives = 46/77 (59%), Gaps = 2/77 (2%)
Query: 1040 ENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHL- 1098
E + ++ V+ + VRLNE+++ SRDA L+++ +P + + YM +LE L++ L
Sbjct: 944 EEITKNRVKSLRQ-VRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLR 1002
Query: 1099 DRVMLVRGGGREVITIY 1115
V+L+RG V+T Y
Sbjct: 1003 PPVILIRGNQENVLTFY 1019
>gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo
sapiens]
Length = 1029
Score = 222 bits (565), Expect = 2e-57
Identities = 160/566 (28%), Positives = 254/566 (44%), Gaps = 95/566 (16%)
Query: 403 LVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVL 462
+ I+FPS TGI+AG+N SGDL+D +IP GT++AI T+ Y++ G+C V+
Sbjct: 342 MFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC----VV 397
Query: 463 RDKFGEAVNGNLVVGT-----LAWPSPW------------------------------VI 487
RD G +N + G LA W +I
Sbjct: 398 RDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLI 456
Query: 488 VIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKA-NGEPTWALLLTACICE 546
G F +T + L L A ++ Q + D + P + FG G N EP LL I
Sbjct: 457 TAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAV 516
Query: 547 IGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLC 606
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G +
Sbjct: 517 AFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIIS 576
Query: 607 LALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPH 666
+ +MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 577 VVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDH 636
Query: 667 TKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAE 726
KN+RPQ LVL P L+ L I G VL G + P+ Q
Sbjct: 637 IKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIA 692
Query: 727 ESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQ 786
+ + K+K F VI+ +LR GV L+Q+ GLG ++ N ++VG+ +NW Q
Sbjct: 693 NGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPA 751
Query: 787 TWRNFIELVRETTAGHLALLVTK-----NVSMFPG---NP---------ERFSEG----- 824
T ++I ++ + + + V + NVS NP E + G
Sbjct: 752 TVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSV 811
Query: 825 --------------------------SIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRI 858
+ID++W+ DGG+ +L+P+LL + W KCK+R+
Sbjct: 812 SGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRV 871
Query: 859 FTVAQMDDNSIQMKKDLTTFLYHLRI 884
F Q+ + Q +K + + L R+
Sbjct: 872 FVGGQI-NRMDQERKAIISLLSKFRL 896
Score = 120 bits (302), Expect = 5e-27
Identities = 65/204 (31%), Positives = 111/204 (54%), Gaps = 13/204 (6%)
Query: 80 EAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFIC 139
E E +K P + R G GV + C+ NI+GVIL+LRL W+ AGI+ ++ ++ +
Sbjct: 118 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 177
Query: 140 CSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGT 199
+ T +T +S+SAI+TNG V +GG+Y++ISRSLGPE GG++GL F AM+ +G
Sbjct: 178 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 237
Query: 200 IEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVF 259
E + L ++ +N++R+ G +T + + G+++ +K ++F
Sbjct: 238 AETVRDLL---------QEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLF 288
Query: 260 LGCVILSILAIYAGVIKSAFDPPN 283
L I+ +A + PP+
Sbjct: 289 ----FLVIMVSFANYLVGTLIPPS 308
Score = 47.4 bits (111), Expect = 8e-05
Identities = 26/77 (33%), Positives = 46/77 (59%), Gaps = 2/77 (2%)
Query: 1040 ENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHL- 1098
E + ++ V+ + VRLNE+++ SRDA L+++ +P + + YM +LE L++ L
Sbjct: 952 EEITKNRVKSLRQ-VRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLR 1010
Query: 1099 DRVMLVRGGGREVITIY 1115
V+L+RG V+T Y
Sbjct: 1011 PPVILIRGNQENVLTFY 1027
>gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo
sapiens]
Length = 1030
Score = 222 bits (565), Expect = 2e-57
Identities = 160/566 (28%), Positives = 254/566 (44%), Gaps = 95/566 (16%)
Query: 403 LVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVL 462
+ I+FPS TGI+AG+N SGDL+D +IP GT++AI T+ Y++ G+C V+
Sbjct: 343 MFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC----VV 398
Query: 463 RDKFGEAVNGNLVVGT-----LAWPSPW------------------------------VI 487
RD G +N + G LA W +I
Sbjct: 399 RDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLI 457
Query: 488 VIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKA-NGEPTWALLLTACICE 546
G F +T + L L A ++ Q + D + P + FG G N EP LL I
Sbjct: 458 TAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAV 517
Query: 547 IGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLC 606
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G +
Sbjct: 518 AFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIIS 577
Query: 607 LALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPH 666
+ +MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 578 VVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDH 637
Query: 667 TKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAE 726
KN+RPQ LVL P L+ L I G VL G + P+ Q
Sbjct: 638 IKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIA 693
Query: 727 ESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQ 786
+ + K+K F VI+ +LR GV L+Q+ GLG ++ N ++VG+ +NW Q
Sbjct: 694 NGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPA 752
Query: 787 TWRNFIELVRETTAGHLALLVTK-----NVSMFPG---NP---------ERFSEG----- 824
T ++I ++ + + + V + NVS NP E + G
Sbjct: 753 TVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSV 812
Query: 825 --------------------------SIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRI 858
+ID++W+ DGG+ +L+P+LL + W KCK+R+
Sbjct: 813 SGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRV 872
Query: 859 FTVAQMDDNSIQMKKDLTTFLYHLRI 884
F Q+ + Q +K + + L R+
Sbjct: 873 FVGGQI-NRMDQERKAIISLLSKFRL 897
Score = 120 bits (302), Expect = 5e-27
Identities = 65/204 (31%), Positives = 111/204 (54%), Gaps = 13/204 (6%)
Query: 80 EAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFIC 139
E E +K P + R G GV + C+ NI+GVIL+LRL W+ AGI+ ++ ++ +
Sbjct: 119 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 178
Query: 140 CSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGT 199
+ T +T +S+SAI+TNG V +GG+Y++ISRSLGPE GG++GL F AM+ +G
Sbjct: 179 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 238
Query: 200 IEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVF 259
E + L ++ +N++R+ G +T + + G+++ +K ++F
Sbjct: 239 AETVRDLL---------QEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLF 289
Query: 260 LGCVILSILAIYAGVIKSAFDPPN 283
L I+ +A + PP+
Sbjct: 290 ----FLVIMVSFANYLVGTLIPPS 309
Score = 47.4 bits (111), Expect = 8e-05
Identities = 26/77 (33%), Positives = 46/77 (59%), Gaps = 2/77 (2%)
Query: 1040 ENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHL- 1098
E + ++ V+ + VRLNE+++ SRDA L+++ +P + + YM +LE L++ L
Sbjct: 953 EEITKNRVKSLRQ-VRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLR 1011
Query: 1099 DRVMLVRGGGREVITIY 1115
V+L+RG V+T Y
Sbjct: 1012 PPVILIRGNQENVLTFY 1028
>gi|4506975 solute carrier family 12 (sodium/potassium/chloride
transporters), member 2 [Homo sapiens]
Length = 1212
Score = 221 bits (563), Expect = 3e-57
Identities = 140/427 (32%), Positives = 218/427 (51%), Gaps = 47/427 (11%)
Query: 393 FSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVL 452
F + ++F++ I+FP+ TGI+AG+N SGDL D Q +IP GT+LAI T+ VY+ V
Sbjct: 481 FREEETFFSVFA-IFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVS 539
Query: 453 FGACIEGVVLRDKFGEA----------------------------------VNGNLVVGT 478
G+C V+RD G +N V+
Sbjct: 540 VGSC----VVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSM 595
Query: 479 LAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVF--GHGKANGEPTW 536
++ +P +I G F +T + L SL AP++ QA+ +D I P Q+F G+GK N EP
Sbjct: 596 VSGFTP-LISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGK-NNEPLR 653
Query: 537 ALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHW 596
+LT I ILIA L+ +API+S FFL Y +N + +L ++P WRP F+YY+
Sbjct: 654 GYILTFLIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNM 713
Query: 597 TLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYA 656
+S LG LC +MF+ +W+ AL+ +I +Y Y+ Y+ + WG + L+ A
Sbjct: 714 WISLLGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQH 773
Query: 657 LLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFL 716
+RL H KN+RPQ LV+ + P LL L GL I G V G
Sbjct: 774 SIRLSGVEDHVKNFRPQCLVMTGAPNSR----PALLHLVHDFTKNVGLMICGHVHMGPRR 829
Query: 717 ENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWP 776
+ + + +R + K+K F V + +LR+G +L+Q+ GLG ++ NT+++G+
Sbjct: 830 QAMKEMSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFK 889
Query: 777 RNWRQKE 783
++W Q +
Sbjct: 890 KDWLQAD 896
Score = 122 bits (306), Expect = 2e-27
Identities = 66/172 (38%), Positives = 101/172 (58%), Gaps = 9/172 (5%)
Query: 96 RMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIAT 155
+ G GV + C+ NI+GV+LF+RL+W+VG AGI S ++ + T +T +S SAIAT
Sbjct: 284 KFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIAT 343
Query: 156 NGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFK 215
NG V GG+YY+ISRSLGPEFGGA+GL F A AMY++G E ++ L +
Sbjct: 344 NGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMI 403
Query: 216 AEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSI 267
E +N++R+ G + + + G+++ K +V L ++L+I
Sbjct: 404 DE---------INDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAI 446
Score = 53.9 bits (128), Expect = 8e-07
Identities = 31/110 (28%), Positives = 65/110 (59%), Gaps = 10/110 (9%)
Query: 823 EGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQM-KKDLTTFLYH 881
+ +IDVWW+ DGG+ +L+P+LL K W+ CK+R+F ++ N I ++ + T L
Sbjct: 1021 KNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKI--NRIDHDRRAMATLLSK 1078
Query: 882 LRIT-AEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREI 930
RI +++ V+ DI+ ++ ++ + +I++ L ++++E++I
Sbjct: 1079 FRIDFSDIMVL----GDINTKPKKENIIAFE--EIIEPYRLHEDDKEQDI 1122
Score = 46.6 bits (109), Expect = 1e-04
Identities = 21/68 (30%), Positives = 41/68 (60%)
Query: 1049 RMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGG 1108
+ + +RLNE++ + S A ++++++P + YM +LE L++ L ++LVRG
Sbjct: 1145 KTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNH 1204
Query: 1109 REVITIYS 1116
+ V+T YS
Sbjct: 1205 QSVLTFYS 1212
>gi|134254459 sodium potassium chloride cotransporter 2 [Homo
sapiens]
Length = 1099
Score = 213 bits (541), Expect = 1e-54
Identities = 138/445 (31%), Positives = 214/445 (48%), Gaps = 45/445 (10%)
Query: 400 FTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEG 459
F + I+FP+ TGI+AG+N SGDL D Q +IP GT+LAI T+ Y+ + GAC
Sbjct: 380 FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGAC--- 436
Query: 460 VVLRDKFGEA---------VNGNLVVG----------------------TLAWPSPW--V 486
V+RD G NG+ G ++ S + +
Sbjct: 437 -VVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPL 495
Query: 487 IVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVF--GHGKANGEPTWALLLTACI 544
I G F +T + L SL AP++ QA+ +D I LQ F G+GK N EP +LT I
Sbjct: 496 ITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGK-NNEPLRGYILTFLI 554
Query: 545 CEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMS 604
ILIA L+ +API+S FFL Y +N +C + ++P WRP + Y+ +S G
Sbjct: 555 AMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAV 614
Query: 605 LCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGP 664
LC A+MF+ +W+ A++ +I +Y Y+ + + WG + LS +A L L
Sbjct: 615 LCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVE 674
Query: 665 PHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQR 724
H KN+RPQ +VL + P LL +T GL I V G +
Sbjct: 675 DHVKNFRPQCIVLT----GGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNS 730
Query: 725 AEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKED 784
+ + K+K F V + RDGV L+Q+ GLG ++ NT+++G+ +NWR K
Sbjct: 731 GMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWR-KAP 789
Query: 785 HQTWRNFIELVRETTAGHLALLVTK 809
N++ ++ + + +++ +
Sbjct: 790 LTEIENYVGIIHDAFDFEIGVVIVR 814
Score = 128 bits (322), Expect = 3e-29
Identities = 80/263 (30%), Positives = 138/263 (52%), Gaps = 19/263 (7%)
Query: 14 GANPGDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVS-SLLSGLANYTNLP 72
G N D PK + +T + G + + ++ E++ + V+ S +AN +P
Sbjct: 102 GHNTMDAVPKIE--YYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVANGDGIP 159
Query: 73 QGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMES 132
G + E E+++ G K G GV + C+ NI+GV+LF+RL+W+VG AGI
Sbjct: 160 -GDEQAENKEDDQAGVVK------FGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLG 212
Query: 133 FCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAG 192
++ + T +T +S SAIATNG V GG+YY+ISRSLGPEFGG++GL F A
Sbjct: 213 VLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAV 272
Query: 193 AMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYV 252
AMY++G E ++ L +++ N++R+ G+ + + + G+++
Sbjct: 273 AMYVVGFAETVVDLL---------KESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWE 323
Query: 253 NKFALVFLGCVILSILAIYAGVI 275
K ++ L ++++I + G +
Sbjct: 324 AKAQVILLVILLIAIANFFIGTV 346
Score = 59.3 bits (142), Expect = 2e-08
Identities = 42/117 (35%), Positives = 67/117 (57%), Gaps = 13/117 (11%)
Query: 1000 DPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEV 1059
+P ++H + KD + AEK K +P I D E E + + + R+ VRLNE+
Sbjct: 996 EPYRLHES-CKDLTTAEKLKRETPWK---ITD-----AELEAVKEKSYRQ----VRLNEL 1042
Query: 1060 IVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS 1116
+ + SR A L++L++P + D YM +LE+LT++L V+LVRG + V+T YS
Sbjct: 1043 LQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099
Score = 58.5 bits (140), Expect = 3e-08
Identities = 31/132 (23%), Positives = 64/132 (48%), Gaps = 3/132 (2%)
Query: 823 EGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFT---VAQMDDNSIQMKKDLTTFL 879
+G+IDVWW+ DGG+ +L+P++L K W+ CK+RI+ + ++++ I M L+ F
Sbjct: 908 KGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFR 967
Query: 880 YHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRG 939
+ + + + S +E+ + + + K + + + ITD
Sbjct: 968 IKFADIHIIGDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWKITDAELE 1027
Query: 940 SIRRKNPANTRL 951
+++ K+ RL
Sbjct: 1028 AVKEKSYRQVRL 1039
>gi|31881740 solute carrier family 12 (potassium/chloride
transporters), member 9 [Homo sapiens]
Length = 914
Score = 193 bits (490), Expect = 9e-49
Identities = 156/549 (28%), Positives = 252/549 (45%), Gaps = 71/549 (12%)
Query: 400 FTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEG 459
F + + F TGIMAG+N SG+L+D ++IP GTI+A+A T VY+ L +
Sbjct: 267 FASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDR 326
Query: 460 VVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIV 519
+L++ +G WP +++IG + + A + SL GA R+L A++RD +
Sbjct: 327 TLLQEDYG------FFRAISLWPP--LVLIGIYATALSASMSSLIGASRILHALARDDLF 378
Query: 520 PFLQVFGHGKANGEPTWALLLTAC-ICEIGILIASLDEVAPILSMFFLMCYMFVNLACAV 578
+ + G WA +L + + ++ +L L+ +A ++++F+L+ Y V+L+C
Sbjct: 379 GVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLS 438
Query: 579 QTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAE 638
PN+RP F + W LG++ CL +MF+ S A ++L+ GL+ + RG
Sbjct: 439 LEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLAALLTARGGP 498
Query: 639 KEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQL 698
WG + L R LLRL+ H K WRPQLL+LV + LL L +QL
Sbjct: 499 SSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGA----LPLLRLANQL 554
Query: 699 KAGKGLTIVGSVLEGTFLENHPQ--AQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSH 756
K G GL ++G V G L++ P Q + L++ +VK F + +S ++R G H
Sbjct: 555 KKG-GLYVLGHVTLGD-LDSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGAQH 612
Query: 757 LIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHL------------- 803
L++ GLGG++ NT+++G+ + ++ T F E T G
Sbjct: 613 LLRISGLGGMKPNTLVLGFYDDAPPQDHFLTDPAFSEPADSTREGSSPALSTLFPPPRAP 672
Query: 804 -----------------ALLVTKNVSMFPGN----PERFSEGS--------IDVW----- 829
AL + KNV + + PER S GS +DVW
Sbjct: 673 GSPRALNPQDYVATVADALKMNKNVVLARASGALPPERLSRGSGGTSQLHHVDVWPLNLL 732
Query: 830 -------WIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHL 882
++ G L+ + +L W ++RIF + + L L L
Sbjct: 733 RPRGGPGYVDVCGLFLLQMATILGMVPAWHSARLRIFLCLGPREAPGAAEGRLRALLSQL 792
Query: 883 RITAEVEVV 891
RI AEV+ V
Sbjct: 793 RIRAEVQEV 801
Score = 108 bits (270), Expect = 3e-23
Identities = 51/121 (42%), Positives = 80/121 (66%)
Query: 84 NEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCT 143
N G A ++ TF+GV +P + ++F +++FLR+ +VVG AG++++ M+ +
Sbjct: 24 NGAGGPGGASARKLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFIL 83
Query: 144 MLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIL 203
LT +S+ AIATNG V GG+Y+MISR+LGPE GG++GL FYL A+ +LG +E +
Sbjct: 84 ALTVLSVCAIATNGAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESV 143
Query: 204 L 204
L
Sbjct: 144 L 144
>gi|38569457 solute carrier family 12, member 8 [Homo sapiens]
Length = 714
Score = 100 bits (249), Expect = 8e-21
Identities = 59/182 (32%), Positives = 103/182 (56%), Gaps = 10/182 (5%)
Query: 393 FSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVL 452
+S S+FT+ G++FP+ TG+MAG N GDLR+ SIP G++ A+ + +YI V L
Sbjct: 227 YSPGESFFTVF-GVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFL 285
Query: 453 FGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQA 512
GA LR F A +L+ ++ ++G + S+ + + L GAPR+LQ
Sbjct: 286 LGAICTREALRYDFLIAEKVSLM--------GFLFLLGLYISSLASCMGGLYGAPRILQC 337
Query: 513 ISRDGIVPFLQVFGHGKA-NGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMF 571
I+++ ++P L G GK N P A+ LT+ + + + ++ +API+++ F++ Y+
Sbjct: 338 IAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVA 397
Query: 572 VN 573
V+
Sbjct: 398 VD 399
Score = 87.4 bits (215), Expect = 7e-17
Identities = 54/176 (30%), Positives = 82/176 (46%), Gaps = 15/176 (8%)
Query: 98 GTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNG 157
GT+ GV+ C+ NIFGV+LFLR W+VG G++ +V ++T +S +
Sbjct: 40 GTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERS 99
Query: 158 VVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAE 217
+ +GG Y MIS LG + GG +GL + G AGAMYI G E + L
Sbjct: 100 SIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLL---------- 149
Query: 218 DASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAG 273
+ +R VL + + GVK++ + L+ L + +S L G
Sbjct: 150 -----GLGNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVG 200
Score = 36.2 bits (82), Expect = 0.18
Identities = 34/122 (27%), Positives = 52/122 (42%), Gaps = 30/122 (24%)
Query: 587 WRPRFRYYH-----WTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEW 641
WR +Y W +S LG L +MF+ W Y LV M +A ++Y YI
Sbjct: 582 WRRSTSFYTHMCNPW-VSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYI--------- 631
Query: 642 GDGIRGLSL-SAARYALLRLEEGPPHTKNWRPQLLV----LVRVDQDQNVVHPQLLSLTS 696
G GL L SA+ ++ R W LL+ +R Q+Q ++ P L +
Sbjct: 632 GRASPGLHLGSASNFSFFR----------WMRSLLLPSCRSLRSPQEQIILAPSLAKVDM 681
Query: 697 QL 698
++
Sbjct: 682 EM 683
>gi|33286430 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 8 isoform b [Homo
sapiens]
Length = 332
Score = 44.7 bits (104), Expect = 5e-04
Identities = 53/206 (25%), Positives = 92/206 (44%), Gaps = 25/206 (12%)
Query: 423 DLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVN-GNLVVGTLAW 481
+L D K++P ++I + VY+ + V + + L AV G ++G +AW
Sbjct: 54 ELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAW 113
Query: 482 PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLT 541
P I ST G SL + RL A +R+G +P + H K P ALL T
Sbjct: 114 IMP----ISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVK-RCTPIPALLFT 168
Query: 542 ACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWR----PRFRYYHWT 597
CI + +L+ S ++ +++ + Y+F + A Q +LR W+ PR
Sbjct: 169 -CISTLLMLVTS--DMYTLINYVGFINYLFYGVTVAGQIVLR---WKKPDIPR------- 215
Query: 598 LSFLGMSLCLALMFICSWYYALVAML 623
+ ++L ++++ W + LV L
Sbjct: 216 --PIKINLLFPIIYLLFWAFLLVFSL 239
>gi|33286428 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 8 isoform a [Homo
sapiens]
Length = 535
Score = 44.7 bits (104), Expect = 5e-04
Identities = 53/206 (25%), Positives = 92/206 (44%), Gaps = 25/206 (12%)
Query: 423 DLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVN-GNLVVGTLAW 481
+L D K++P ++I + VY+ + V + + L AV G ++G +AW
Sbjct: 257 ELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAW 316
Query: 482 PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLT 541
P I ST G SL + RL A +R+G +P + H K P ALL T
Sbjct: 317 IMP----ISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVK-RCTPIPALLFT 371
Query: 542 ACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWR----PRFRYYHWT 597
CI + +L+ S ++ +++ + Y+F + A Q +LR W+ PR
Sbjct: 372 -CISTLLMLVTS--DMYTLINYVGFINYLFYGVTVAGQIVLR---WKKPDIPR------- 418
Query: 598 LSFLGMSLCLALMFICSWYYALVAML 623
+ ++L ++++ W + LV L
Sbjct: 419 --PIKINLLFPIIYLLFWAFLLVFSL 442
>gi|195976805 hypoxia up-regulated 1 precursor [Homo sapiens]
Length = 999
Score = 42.0 bits (97), Expect = 0.003
Identities = 36/125 (28%), Positives = 58/125 (46%), Gaps = 15/125 (12%)
Query: 957 EETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAE 1016
E A S+++P E+V+L + AP S P P EP+G+ + EK DKS A+
Sbjct: 606 ESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPP-PEPKGDATPEGEKATEKENGDKSEAQ 664
Query: 1017 KNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPG 1076
K + EG+ + PE E + +R R+ E I +LV+L++P
Sbjct: 665 KPSEKAEAGPEGV----APAPEGEKKQKPARKR-----RMVEEI-----GVELVVLDLPD 710
Query: 1077 PPRNR 1081
P ++
Sbjct: 711 LPEDK 715
>gi|5453832 hypoxia up-regulated 1 precursor [Homo sapiens]
Length = 999
Score = 42.0 bits (97), Expect = 0.003
Identities = 36/125 (28%), Positives = 58/125 (46%), Gaps = 15/125 (12%)
Query: 957 EETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAE 1016
E A S+++P E+V+L + AP S P P EP+G+ + EK DKS A+
Sbjct: 606 ESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPP-PEPKGDATPEGEKATEKENGDKSEAQ 664
Query: 1017 KNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPG 1076
K + EG+ + PE E + +R R+ E I +LV+L++P
Sbjct: 665 KPSEKAEAGPEGV----APAPEGEKKQKPARKR-----RMVEEI-----GVELVVLDLPD 710
Query: 1077 PPRNR 1081
P ++
Sbjct: 711 LPEDK 715
>gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo
sapiens]
Length = 697
Score = 40.0 bits (92), Expect = 0.012
Identities = 37/157 (23%), Positives = 66/157 (42%), Gaps = 8/157 (5%)
Query: 423 DLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAW- 481
++R+ QK+IP G + ++ Y + +L +K V V W
Sbjct: 320 EVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYV----GWG 375
Query: 482 PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLT 541
P+ +V+ GS + + L S+ PR+L A++RDG++ + P A L
Sbjct: 376 PAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGLL--FRFLARVSKRQSPVAATLTA 433
Query: 542 ACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAV 578
I + + L + ++S+ LM Y V AC +
Sbjct: 434 GVISALMAFLFDLKALVDMMSIGTLMAYSLV-AACVL 469
>gi|187423910 solute carrier family 7, member 9 [Homo sapiens]
Length = 487
Score = 38.9 bits (89), Expect = 0.027
Identities = 50/216 (23%), Positives = 88/216 (40%), Gaps = 12/216 (5%)
Query: 423 DLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVN-GNLVVGTLAW 481
+LR+ +++P I+ I +A YI V + + L AV G+ V+ +
Sbjct: 244 ELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATELLQSQAVAVTFGDRVL----Y 299
Query: 482 PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANG-EPTWALLL 540
P+ W++ + FST GA + A RL+ R+G L+V + P A++
Sbjct: 300 PASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREG--HMLKVLSYISVRRLTPAPAIIF 357
Query: 541 TACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSF 600
I I I+ ++ + S + Y L V R RP +
Sbjct: 358 YGIIATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRFTRKELERPIKVPVVIPVLM 417
Query: 601 LGMSLCLALMFICS---W-YYALVAMLIAGLIYKYI 632
+S+ L L I S W Y V +++GL++ ++
Sbjct: 418 TLISVFLVLAPIISKPTWEYLYCVLFILSGLLFYFL 453
>gi|7657591 solute carrier family 7, member 9 [Homo sapiens]
Length = 487
Score = 38.9 bits (89), Expect = 0.027
Identities = 50/216 (23%), Positives = 88/216 (40%), Gaps = 12/216 (5%)
Query: 423 DLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVN-GNLVVGTLAW 481
+LR+ +++P I+ I +A YI V + + L AV G+ V+ +
Sbjct: 244 ELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATELLQSQAVAVTFGDRVL----Y 299
Query: 482 PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANG-EPTWALLL 540
P+ W++ + FST GA + A RL+ R+G L+V + P A++
Sbjct: 300 PASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREG--HMLKVLSYISVRRLTPAPAIIF 357
Query: 541 TACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSF 600
I I I+ ++ + S + Y L V R RP +
Sbjct: 358 YGIIATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRFTRKELERPIKVPVVIPVLM 417
Query: 601 LGMSLCLALMFICS---W-YYALVAMLIAGLIYKYI 632
+S+ L L I S W Y V +++GL++ ++
Sbjct: 418 TLISVFLVLAPIISKPTWEYLYCVLFILSGLLFYFL 453
>gi|56676330 HP1-BP74 [Homo sapiens]
Length = 553
Score = 38.5 bits (88), Expect = 0.036
Identities = 29/121 (23%), Positives = 52/121 (42%), Gaps = 7/121 (5%)
Query: 929 EIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPS 988
+++ T R ++ + +L EE + + EE V + +Q + P++S S
Sbjct: 33 KVEDSTMPIRRTVNSTRETPPKSKLAEGEEEKPEPDISSEESVSTVEEQENETPPATS-S 91
Query: 989 PGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVR 1048
E+P+GE E + ++ ++KS E K S E K P W L+ S +
Sbjct: 92 EAEQPKGEPENEEKE------ENKSSEETKKDEKDQSKEKEKKVKKTIPSWATLSASQLA 145
Query: 1049 R 1049
R
Sbjct: 146 R 146
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 37.7 bits (86), Expect = 0.061
Identities = 40/140 (28%), Positives = 62/140 (44%), Gaps = 12/140 (8%)
Query: 955 VPEETAGDSE-EKPEEEVQLIHDQSAPSCPSSSP-SPGEEPEGEGETDPEKVHLTWTKDK 1012
+P+E GD+ EKPE+ L S S S + +G+ ET P K + T K
Sbjct: 796 IPDE--GDTTPEKPEDPSALSKQSSEVSMREESDIDQNQSDDGDTETSPTK---SPTTPK 850
Query: 1013 SVAEKNKGPSPVSSEGIKDFFSMKPEWEN----LNQSNVRRMHTAVRLNEVIVKKSRDAK 1068
SV KN P+ S + E +N L+ ++ + TA NE K + +
Sbjct: 851 SVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSALSAASAFAIATA-GANEGTPNKEKYRR 909
Query: 1069 LVLLNMPGPPRNRNGDENYM 1088
+ L + PP RNGD+ ++
Sbjct: 910 MSLASAGFPPDQRNGDKEFV 929
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,239,821
Number of Sequences: 37866
Number of extensions: 2015780
Number of successful extensions: 7540
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 27
Number of HSP's successfully gapped in prelim test: 91
Number of HSP's that attempted gapping in prelim test: 7306
Number of HSP's gapped (non-prelim): 247
length of query: 1116
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1003
effective length of database: 13,968,660
effective search space: 14010565980
effective search space used: 14010565980
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.