Search of human proteins with 119395760

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
         (1263 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]                   2516   0.0  
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]                   2508   0.0  
gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]                   1082   0.0  
gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]                   1082   0.0  
gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens]            942   0.0  
gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens]             796   0.0  
gi|21071077 dishevelled-associated activator of morphogenesis 1 ...   396   e-110
gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]               339   9e-93
gi|149999380 inverted formin 2 isoform 1 [Homo sapiens]               339   9e-93
gi|160707881 formin 2 [Homo sapiens]                                  318   2e-86
gi|40548415 dishevelled associated activator of morphogenesis 2 ...   263   8e-70
gi|33356148 formin-like 1 [Homo sapiens]                              232   1e-60
gi|157168329 formin 1 [Homo sapiens]                                  229   1e-59
gi|52485606 formin-like 2 [Homo sapiens]                              206   9e-53
gi|145309324 FH2 domain containing 1 [Homo sapiens]                   195   3e-49
gi|119120861 formin-like 3 isoform 2 [Homo sapiens]                   191   3e-48
gi|119120874 formin-like 3 isoform 1 [Homo sapiens]                   191   3e-48
gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2) int...   172   2e-42
gi|58331242 formin homology 2 domain containing 3 [Homo sapiens]      144   5e-34
gi|118572599 formin homology 2 domain containing 1 [Homo sapiens]     133   9e-31
gi|11386183 WAS protein family, member 2 [Homo sapiens]               118   3e-26
gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo sap...   118   4e-26
gi|117306167 proline-rich protein BstNI subfamily 3 precursor [H...   117   7e-26
gi|148536848 carboxyl ester lipase precursor [Homo sapiens]           116   2e-25
gi|162329583 cleavage and polyadenylation specific factor 6, 68 ...   112   2e-24
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]    111   4e-24
gi|153792074 proline rich 12 [Homo sapiens]                           109   2e-23
gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1 pre...   108   3e-23
gi|122937496 WAS/WASL interacting protein family, member 3 [Homo...   108   4e-23
gi|4826998 splicing factor proline/glutamine rich (polypyrimidin...   108   4e-23

>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
          Length = 1263

 Score = 2516 bits (6521), Expect = 0.0
 Identities = 1263/1263 (100%), Positives = 1263/1263 (100%)

Query: 1    MEPPGGSLGPGRGTRDKKKGRSPDELPSAGGDGGKSKKFLERFTSMRIKKEKEKPNSAHR 60
            MEPPGGSLGPGRGTRDKKKGRSPDELPSAGGDGGKSKKFLERFTSMRIKKEKEKPNSAHR
Sbjct: 1    MEPPGGSLGPGRGTRDKKKGRSPDELPSAGGDGGKSKKFLERFTSMRIKKEKEKPNSAHR 60

Query: 61   NSSASYGDDPTAQSLQDVSDEQVLVLFEQMLLDMNLNEEKQQPLREKDIIIKREMVSQYL 120
            NSSASYGDDPTAQSLQDVSDEQVLVLFEQMLLDMNLNEEKQQPLREKDIIIKREMVSQYL
Sbjct: 61   NSSASYGDDPTAQSLQDVSDEQVLVLFEQMLLDMNLNEEKQQPLREKDIIIKREMVSQYL 120

Query: 121  YTSKAGMSQKESSKSAMMYIQELRSGLRDMPLLSCLESLRVSLNNNPVSWVQTFGAEGLA 180
            YTSKAGMSQKESSKSAMMYIQELRSGLRDMPLLSCLESLRVSLNNNPVSWVQTFGAEGLA
Sbjct: 121  YTSKAGMSQKESSKSAMMYIQELRSGLRDMPLLSCLESLRVSLNNNPVSWVQTFGAEGLA 180

Query: 181  SLLDILKRLHDEKEETAGSYDSRNKHEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMD 240
            SLLDILKRLHDEKEETAGSYDSRNKHEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMD
Sbjct: 181  SLLDILKRLHDEKEETAGSYDSRNKHEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMD 240

Query: 241  PAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEMDEVERFQPLLDGLKSGTTIA 300
            PAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEMDEVERFQPLLDGLKSGTTIA
Sbjct: 241  PAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEMDEVERFQPLLDGLKSGTTIA 300

Query: 301  LKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQG 360
            LKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQG
Sbjct: 301  LKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQG 360

Query: 361  EEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQ 420
            EEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQ
Sbjct: 361  EEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQ 420

Query: 421  YYKLIEECISQIVLHKNGADPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLD 480
            YYKLIEECISQIVLHKNGADPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLD
Sbjct: 421  YYKLIEECISQIVLHKNGADPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLD 480

Query: 481  SELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVA 540
            SELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVA
Sbjct: 481  SELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVA 540

Query: 541  KLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPP 600
            KLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPP
Sbjct: 541  KLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPP 600

Query: 601  PPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSL 660
            PPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSL
Sbjct: 601  PPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSL 660

Query: 661  PGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPP 720
            PGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPP
Sbjct: 661  PGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPP 720

Query: 721  PPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKLVA 780
            PPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKLVA
Sbjct: 721  PPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKLVA 780

Query: 781  EDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKEL 840
            EDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKEL
Sbjct: 781  EDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKEL 840

Query: 841  KVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSE 900
            KVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSE
Sbjct: 841  KVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSE 900

Query: 901  LKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRK 960
            LKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRK
Sbjct: 901  LKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRK 960

Query: 961  SESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCEN 1020
            SESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCEN
Sbjct: 961  SESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCEN 1020

Query: 1021 DYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEK 1080
            DYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEK
Sbjct: 1021 DYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEK 1080

Query: 1081 MTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAV 1140
            MTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAV
Sbjct: 1081 MTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAV 1140

Query: 1141 KENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSG 1200
            KENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSG
Sbjct: 1141 KENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSG 1200

Query: 1201 AAFRRKRGPRQANRKAGCAVTSLLASELTKDDAMAAVPAKVSKNSETFPTILEEAKELVG 1260
            AAFRRKRGPRQANRKAGCAVTSLLASELTKDDAMAAVPAKVSKNSETFPTILEEAKELVG
Sbjct: 1201 AAFRRKRGPRQANRKAGCAVTSLLASELTKDDAMAAVPAKVSKNSETFPTILEEAKELVG 1260

Query: 1261 RAS 1263
            RAS
Sbjct: 1261 RAS 1263


>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
          Length = 1272

 Score = 2508 bits (6501), Expect = 0.0
 Identities = 1263/1272 (99%), Positives = 1263/1272 (99%), Gaps = 9/1272 (0%)

Query: 1    MEPPGGSLGPGRGTRDKKKGRSPDELPSAGGDGGKSKKF---------LERFTSMRIKKE 51
            MEPPGGSLGPGRGTRDKKKGRSPDELPSAGGDGGKSKKF         LERFTSMRIKKE
Sbjct: 1    MEPPGGSLGPGRGTRDKKKGRSPDELPSAGGDGGKSKKFTLKRLMADELERFTSMRIKKE 60

Query: 52   KEKPNSAHRNSSASYGDDPTAQSLQDVSDEQVLVLFEQMLLDMNLNEEKQQPLREKDIII 111
            KEKPNSAHRNSSASYGDDPTAQSLQDVSDEQVLVLFEQMLLDMNLNEEKQQPLREKDIII
Sbjct: 61   KEKPNSAHRNSSASYGDDPTAQSLQDVSDEQVLVLFEQMLLDMNLNEEKQQPLREKDIII 120

Query: 112  KREMVSQYLYTSKAGMSQKESSKSAMMYIQELRSGLRDMPLLSCLESLRVSLNNNPVSWV 171
            KREMVSQYLYTSKAGMSQKESSKSAMMYIQELRSGLRDMPLLSCLESLRVSLNNNPVSWV
Sbjct: 121  KREMVSQYLYTSKAGMSQKESSKSAMMYIQELRSGLRDMPLLSCLESLRVSLNNNPVSWV 180

Query: 172  QTFGAEGLASLLDILKRLHDEKEETAGSYDSRNKHEIIRCLKAFMNNKFGIKTMLETEEG 231
            QTFGAEGLASLLDILKRLHDEKEETAGSYDSRNKHEIIRCLKAFMNNKFGIKTMLETEEG
Sbjct: 181  QTFGAEGLASLLDILKRLHDEKEETAGSYDSRNKHEIIRCLKAFMNNKFGIKTMLETEEG 240

Query: 232  ILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEMDEVERFQPLLD 291
            ILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEMDEVERFQPLLD
Sbjct: 241  ILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEMDEVERFQPLLD 300

Query: 292  GLKSGTTIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQDLREIENEDMRV 351
            GLKSGTTIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQDLREIENEDMRV
Sbjct: 301  GLKSGTTIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQDLREIENEDMRV 360

Query: 352  QLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSILQHLLLV 411
            QLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSILQHLLLV
Sbjct: 361  QLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSILQHLLLV 420

Query: 412  RNDYEARPQYYKLIEECISQIVLHKNGADPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAK 471
            RNDYEARPQYYKLIEECISQIVLHKNGADPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAK
Sbjct: 421  RNDYEARPQYYKLIEECISQIVLHKNGADPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAK 480

Query: 472  AAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIATEKQDLEAE 531
            AAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIATEKQDLEAE
Sbjct: 481  AAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIATEKQDLEAE 540

Query: 532  VSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPP 591
            VSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPP
Sbjct: 541  VSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPP 600

Query: 592  APGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEG 651
            APGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEG
Sbjct: 601  APGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEG 660

Query: 652  VGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPL 711
            VGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPL
Sbjct: 661  VGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPL 720

Query: 712  PGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLR 771
            PGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLR
Sbjct: 721  PGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLR 780

Query: 772  RPNWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKDQEGGEEKKS 831
            RPNWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKDQEGGEEKKS
Sbjct: 781  RPNWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKDQEGGEEKKS 840

Query: 832  VQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPE 891
            VQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPE
Sbjct: 841  VQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPE 900

Query: 892  PEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSV 951
            PEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSV
Sbjct: 901  PEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSV 960

Query: 952  TAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLL 1011
            TAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLL
Sbjct: 961  TAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLL 1020

Query: 1012 HFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAAT 1071
            HFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAAT
Sbjct: 1021 HFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAAT 1080

Query: 1072 DEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHN 1131
            DEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHN
Sbjct: 1081 DEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHN 1140

Query: 1132 FRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMD 1191
            FRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMD
Sbjct: 1141 FRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMD 1200

Query: 1192 SLLEALQSGAAFRRKRGPRQANRKAGCAVTSLLASELTKDDAMAAVPAKVSKNSETFPTI 1251
            SLLEALQSGAAFRRKRGPRQANRKAGCAVTSLLASELTKDDAMAAVPAKVSKNSETFPTI
Sbjct: 1201 SLLEALQSGAAFRRKRGPRQANRKAGCAVTSLLASELTKDDAMAAVPAKVSKNSETFPTI 1260

Query: 1252 LEEAKELVGRAS 1263
            LEEAKELVGRAS
Sbjct: 1261 LEEAKELVGRAS 1272


>gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]
          Length = 1096

 Score = 1082 bits (2799), Expect = 0.0
 Identities = 612/1250 (48%), Positives = 803/1250 (64%), Gaps = 194/1250 (15%)

Query: 1    MEPPGGSL-GPGRGTRDKKKGRSPDELP---SAGGDGGKSKKFL------------ERFT 44
            ME PG +  G G G+ +   GRS        +A  +  K+K  L            +R T
Sbjct: 1    MEQPGAAASGAGGGSEEPGGGRSNKRSAGNRAANEEETKNKPKLNIQIKTLADDVRDRIT 60

Query: 45   SMRIKK-EKEKPNSAHR-NSSASYGDDPTAQSLQD-----VSDEQVLVLFEQMLLDMNLN 97
            S R    +KEKP   H  +S  +  + P AQ L D     +S+++VL LFE+M+ DMNLN
Sbjct: 61   SFRKSTVKKEKPLIQHPIDSQVAMSEFPAAQPLYDERSLNLSEKEVLDLFEKMMEDMNLN 120

Query: 98   EEKQQPLREKDIIIKREMVSQYLY-TSKAG---MSQKESSKSAMMYIQELRSGLRDMPLL 153
            EEK+ PLR KD   KREMV QY+  T+K+G    S+ E + S+  Y+ ELRSG+ D  LL
Sbjct: 121  EEKKAPLRNKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQEYVHELRSGISDEKLL 180

Query: 154  SCLESLRVSLNNNPVSWVQTFGAEGLASLLDILKRLHDEKEETAGSYDSRNKHEIIRCLK 213
            +CLESLRVSL +NPVSWV  FG EGL  LLD L++L D+K++   + D +N++++I+CLK
Sbjct: 181  NCLESLRVSLTSNPVSWVNNFGHEGLGLLLDELEKLLDKKQQE--NIDKKNQYKLIQCLK 238

Query: 214  AFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEA 273
            AFMNNKFG++ +L  E  +LLL RA+DP  PNMM +  K+LSA+CI+ + E++ +++L A
Sbjct: 239  AFMNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIVGE-ENILDKLLGA 297

Query: 274  MTERAEMDEVERFQPLLDGLKSGTTIALKVGCLQLINALITPAEELDFRVHIRSELMRLG 333
            +T  AE +  ERF P+++GL++   + L+V C+Q INAL+T   ELDFR+H+R+E +R G
Sbjct: 298  ITTAAERNNRERFSPIVEGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSG 357

Query: 334  LHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVK 393
            L  +L DL+E EN+++ +QL VFDE  E+D  +L  RL+DIR EMDD NEV+ +L N +K
Sbjct: 358  LKTMLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLK 417

Query: 394  DSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDFKCRH-LQIEI 452
            D+ AE +FLSILQH LL+RNDY  RPQYYK+IEEC+SQIVLH +G DPDFK R  L I++
Sbjct: 418  DTAAENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDL 477

Query: 453  EGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKD 512
              LID  ++K KVE+SE KAAE  KK D E                              
Sbjct: 478  THLIDSCVNKAKVEESEQKAAEFSKKFDEEF----------------------------- 508

Query: 513  ALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAP 572
                      T +Q+ +AE+ +   ++ +L  E++  + +   LS+++            
Sbjct: 509  ----------TARQEAQAELQKRDEKIKELEAEIQQLRTQAQVLSSSS------------ 546

Query: 573  VPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISP 632
                  +PG                        PP  PPLPG               + P
Sbjct: 547  -----GIPG------------------------PPAAPPLPG---------------VGP 562

Query: 633  PPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIP 692
            PPP       PP PPLP G  +P           PPPPPLPG   IPPPPPP P   G P
Sbjct: 563  PPP-------PPAPPLPGGAPLP-----------PPPPPLPGMMGIPPPPPP-PLLFGGP 603

Query: 693  PPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAP 752
            PPPPPL G                              PPPPG+ +              
Sbjct: 604  PPPPPLGG-----------------------------VPPPPGISLN------------- 621

Query: 753  VLPFGLTPKKLYKPEVQLRRPNWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSA 812
             LP+G+  KK+YKPEV ++R NWSK+   +LS++CFW +VKED+FEN +LFAKL L F+ 
Sbjct: 622  -LPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRVKEDKFENPDLFAKLALNFAT 680

Query: 813  QTKTSKAKKDQEGGEEKKS-VQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILE 871
            Q    K +K+ E  EEKK+   KKKVKEL++LD KTAQNLSIFLGS+RMPY++I+NVILE
Sbjct: 681  QI---KVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILE 737

Query: 872  VNEAVLTESMIQNLIKQMPEPEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAI 931
            VNE +L+E++IQNL+K +PE + L  L+ELK+EYDDL E EQFGVVM +V  L+PRL++I
Sbjct: 738  VNEDMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSI 797

Query: 932  LFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFN 991
            LFKL F E + NIKP I++VT ACEEL+KSESF+ LLE+ LLVGNYMN+GSRNA + GF 
Sbjct: 798  LFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFK 857

Query: 992  ISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLD 1051
            I+FLCK+RDTKS DQK TLLHF+A++CE  Y D+LKFP+EL HVE AS+VSA+ L+ NL 
Sbjct: 858  INFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSNLA 917

Query: 1052 QMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGE 1111
             M++QI  +ERD++ FP A ++ DKFVEKMTSF K A+EQY KL  MH+NM  LY+ LGE
Sbjct: 918  SMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNMMKLYENLGE 977

Query: 1112 YFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQ 1171
            YF+FD K +S+EEFF DL+NFR +FL+AV+EN KRRE EEK RRAKLAKEKAE+E+LE+Q
Sbjct: 978  YFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKEKAEQEKLERQ 1037

Query: 1172 QKREQLIDMNAEGDETGVMDSLLEALQSGAAF--RRKRGPRQANRKAGCA 1219
            +K++QLID+N EGDETGVMD+LLEALQSGAAF  RRKR PR       CA
Sbjct: 1038 KKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRRKRIPRNPVVNHPCA 1087


>gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]
          Length = 1101

 Score = 1082 bits (2799), Expect = 0.0
 Identities = 610/1246 (48%), Positives = 803/1246 (64%), Gaps = 194/1246 (15%)

Query: 1    MEPPGGSL-GPGRGTRDKKKGRSPDELP---SAGGDGGKSKKFL------------ERFT 44
            ME PG +  G G G+ +   GRS        +A  +  K+K  L            +R T
Sbjct: 1    MEQPGAAASGAGGGSEEPGGGRSNKRSAGNRAANEEETKNKPKLNIQIKTLADDVRDRIT 60

Query: 45   SMRIKK-EKEKPNSAHR-NSSASYGDDPTAQSLQD-----VSDEQVLVLFEQMLLDMNLN 97
            S R    +KEKP   H  +S  +  + P AQ L D     +S+++VL LFE+M+ DMNLN
Sbjct: 61   SFRKSTVKKEKPLIQHPIDSQVAMSEFPAAQPLYDERSLNLSEKEVLDLFEKMMEDMNLN 120

Query: 98   EEKQQPLREKDIIIKREMVSQYLY-TSKAG---MSQKESSKSAMMYIQELRSGLRDMPLL 153
            EEK+ PLR KD   KREMV QY+  T+K+G    S+ E + S+  Y+ ELRSG+ D  LL
Sbjct: 121  EEKKAPLRNKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQEYVHELRSGISDEKLL 180

Query: 154  SCLESLRVSLNNNPVSWVQTFGAEGLASLLDILKRLHDEKEETAGSYDSRNKHEIIRCLK 213
            +CLESLRVSL +NPVSWV  FG EGL  LLD L++L D+K++   + D +N++++I+CLK
Sbjct: 181  NCLESLRVSLTSNPVSWVNNFGHEGLGLLLDELEKLLDKKQQE--NIDKKNQYKLIQCLK 238

Query: 214  AFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEA 273
            AFMNNKFG++ +L  E  +LLL RA+DP  PNMM +  K+LSA+CI+ + E++ +++L A
Sbjct: 239  AFMNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIVGE-ENILDKLLGA 297

Query: 274  MTERAEMDEVERFQPLLDGLKSGTTIALKVGCLQLINALITPAEELDFRVHIRSELMRLG 333
            +T  AE +  ERF P+++GL++   + L+V C+Q INAL+T   ELDFR+H+R+E +R G
Sbjct: 298  ITTAAERNNRERFSPIVEGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSG 357

Query: 334  LHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVK 393
            L  +L DL+E EN+++ +QL VFDE  E+D  +L  RL+DIR EMDD NEV+ +L N +K
Sbjct: 358  LKTMLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLK 417

Query: 394  DSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDFKCRH-LQIEI 452
            D+ AE +FLSILQH LL+RNDY  RPQYYK+IEEC+SQIVLH +G DPDFK R  L I++
Sbjct: 418  DTAAENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDL 477

Query: 453  EGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKD 512
              LID  ++K KVE+SE KAAE  KK D E                              
Sbjct: 478  THLIDSCVNKAKVEESEQKAAEFSKKFDEEF----------------------------- 508

Query: 513  ALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAP 572
                      T +Q+ +AE+ +   ++ +L  E++  + +   LS+++            
Sbjct: 509  ----------TARQEAQAELQKRDEKIKELEAEIQQLRTQAQVLSSSS------------ 546

Query: 573  VPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISP 632
                  +PG                        PP  PPLPG               + P
Sbjct: 547  -----GIPG------------------------PPAAPPLPG---------------VGP 562

Query: 633  PPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIP 692
            PPP       PP PPLP G  +P           PPPPPLPG   IPPPPPP P   G P
Sbjct: 563  PPP-------PPAPPLPGGAPLP-----------PPPPPLPGMMGIPPPPPP-PLLFGGP 603

Query: 693  PPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAP 752
            PPPPPL G                              PPPPG+ +              
Sbjct: 604  PPPPPLGG-----------------------------VPPPPGISLN------------- 621

Query: 753  VLPFGLTPKKLYKPEVQLRRPNWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSA 812
             LP+G+  KK+YKPEV ++R NWSK+   +LS++CFW +VKED+FEN +LFAKL L F+ 
Sbjct: 622  -LPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRVKEDKFENPDLFAKLALNFAT 680

Query: 813  QTKTSKAKKDQEGGEEKKS-VQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILE 871
            Q    K +K+ E  EEKK+   KKKVKEL++LD KTAQNLSIFLGS+RMPY++I+NVILE
Sbjct: 681  QI---KVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILE 737

Query: 872  VNEAVLTESMIQNLIKQMPEPEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAI 931
            VNE +L+E++IQNL+K +PE + L  L+ELK+EYDDL E EQFGVVM +V  L+PRL++I
Sbjct: 738  VNEDMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSI 797

Query: 932  LFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFN 991
            LFKL F E + NIKP I++VT ACEEL+KSESF+ LLE+ LLVGNYMN+GSRNA + GF 
Sbjct: 798  LFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFK 857

Query: 992  ISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLD 1051
            I+FLCK+RDTKS DQK TLLHF+A++CE  Y D+LKFP+EL HVE AS+VSA+ L+ NL 
Sbjct: 858  INFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSNLA 917

Query: 1052 QMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGE 1111
             M++QI  +ERD++ FP A ++ DKFVEKMTSF K A+EQY KL  MH+NM  LY+ LGE
Sbjct: 918  SMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNMMKLYENLGE 977

Query: 1112 YFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQ 1171
            YF+FD K +S+EEFF DL+NFR +FL+AV+EN KRRE EEK RRAKLAKEKAE+E+LE+Q
Sbjct: 978  YFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKEKAEQEKLERQ 1037

Query: 1172 QKREQLIDMNAEGDETGVMDSLLEALQSGAAF--RRKRGPRQANRK 1215
            +K++QLID+N EGDETGVMD+LLEALQSGAAF  RRKR PR  + +
Sbjct: 1038 KKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRRKRIPRNPDNR 1083


>gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens]
          Length = 1193

 Score =  942 bits (2435), Expect = 0.0
 Identities = 543/1224 (44%), Positives = 746/1224 (60%), Gaps = 194/1224 (15%)

Query: 12   RGTRDKKKGR--SPDELPSAGGD---GGKSKKF-----------LERFTSMRIKKEKEKP 55
            RG R+ K  R   P   P   G    G K  KF           L++F S+RI   K++ 
Sbjct: 28   RGCRESKMPRRKGPQHPPPPSGPEEPGEKRPKFHLNIRTLTDDMLDKFASIRIPGSKKER 87

Query: 56   NSAHRNSSASYGDDPTAQSLQ-------DVSDEQVLVLFEQMLLDMNLNEEKQQPLREKD 108
                   +A    D +A  L+        +S+ ++L LFE+M+ DMNLNE+K+ PLREKD
Sbjct: 88   PPLPNLKTAFASSDCSAAPLEMMENFPKPLSENELLELFEKMMEDMNLNEDKKAPLREKD 147

Query: 109  IIIKREMVSQYLYT-SKAGMSQKESSKSAMMYIQELRSGLRDMPLLSCLESLRVSLNNNP 167
              IK+EMV QY+ T SK G  ++    S   +I EL+ G  D  L++CLESLRVSL +NP
Sbjct: 148  FSIKKEMVMQYINTASKTGSLKRSRQISPQEFIHELKMGSADERLVTCLESLRVSLTSNP 207

Query: 168  VSWVQTFGAEGLASLLDILKRLHDEKEETAGSYDSRNKHEIIRCLKAFMNNKFGIKTMLE 227
            VSWV++FG EGL  LLDIL++L   K +       +N+H++I+CLKA MN ++G++ ++ 
Sbjct: 208  VSWVESFGHEGLGLLLDILEKLISGKIQE--KVVKKNQHKVIQCLKALMNTQYGLERIMS 265

Query: 228  TEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEMDEVERFQ 287
             E  + LL +A+DP  PNMM D  KLLSA+CI+ + E + E VLEA+T   E  +++RF 
Sbjct: 266  EERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGE-ESILEEVLEALTSAGEEKKIDRFF 324

Query: 288  PLLDGLKSGTTIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQDLREIENE 347
             +++GL+  + + L+V C+QLINAL+T  ++LDFR+HIR+E MR GL ++L +L+ I+N+
Sbjct: 325  CIVEGLRHNS-VQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKND 383

Query: 348  DMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSILQH 407
             + +QL VFDE  EED ++L  RL+DIR E+D+  +V+ ++ +TVK+++AE +F+SILQH
Sbjct: 384  GLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQH 443

Query: 408  LLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDFKCRHLQIEIEGLIDQMIDKTKVEK 467
            LLL+RNDY  R QY+KLI+EC+SQIVLH++G DPDF  R                     
Sbjct: 444  LLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYR--------------------- 482

Query: 468  SEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIATEKQD 527
                     K+LD +LT   ++ ++  K+E +FE+K  +       L+ + ++  T+ Q+
Sbjct: 483  ---------KRLDLDLTQFVDICIDQAKLE-EFEEKASE-------LYKKFEKEFTDHQE 525

Query: 528  LEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTII 587
             +A       E+ K   ++ + + E+ +  +                    LP D     
Sbjct: 526  TQA-------ELQKKEAKINELQAELQAFKSQF----------------GALPADCNI-- 560

Query: 588  PPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPP 647
                               P PP   GG          G +A+ PPPPL     +PPPPP
Sbjct: 561  -------------------PLPPSKEGGT---------GHSALPPPPPLPSGGGVPPPPP 592

Query: 648  LPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPP 707
                               PPPPPLPG          +P S  +PPP             
Sbjct: 593  ------------------PPPPPPLPGMR--------MPFSGPVPPP------------- 613

Query: 708  PPPLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPKKLYKPE 767
                       PP  F GG   PP                    P+LPFGL PKK +KPE
Sbjct: 614  -----------PPLGFLGGQNSPP-------------------LPILPFGLKPKKEFKPE 643

Query: 768  VQLRRPNWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKDQEGGE 827
            + +RR NW K+   +++++CFW KV E+++EN +L  KL  TF  Q    K ++++E  E
Sbjct: 644  ISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQ---QKERREEEDIE 700

Query: 828  EKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIK 887
            EKKS+ KKK+KELK LDSK AQNLSIFL SFR+PY+EI+ +ILEV+E  L ESMIQNLIK
Sbjct: 701  EKKSI-KKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNLIK 759

Query: 888  QMPEPEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPE 947
             +P+ EQL  LS+ K EY +L E EQF VVM  V RLRPRL+AILFKLQF EQV NIKP+
Sbjct: 760  HLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPD 819

Query: 948  IVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQK 1007
            I++V+ ACEE++KS+SFS LLE+ LL+GNYMNAGSRNA  FGFN+S LCKL+DTKS DQK
Sbjct: 820  IMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSADQK 879

Query: 1008 MTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNF 1067
             TLLHFL E+CE  YPD+L F D+L  ++KAS+VS E L+KNL QM +Q+  +E++++ F
Sbjct: 880  TTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELETF 939

Query: 1068 PAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFM 1127
            P   D  DKFV KM+ FV  A+EQY  L  +H NME LY+ +  Y+  D KK+SVE+F  
Sbjct: 940  PPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVEDFLT 999

Query: 1128 DLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDET 1187
            DL+NFR  F+QA+KEN K+RE EEK +R ++AKE AE+ERLE+QQK+++L++M  EGDET
Sbjct: 1000 DLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEGDET 1059

Query: 1188 GVMDSLLEALQSGAAF--RRKRGP 1209
            GVMD+LLEALQSGAAF  RRKR P
Sbjct: 1060 GVMDNLLEALQSGAAFRDRRKRTP 1083


>gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens]
          Length = 849

 Score =  796 bits (2055), Expect = 0.0
 Identities = 447/986 (45%), Positives = 609/986 (61%), Gaps = 168/986 (17%)

Query: 226  LETEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEMDEVER 285
            +  E  + LL +A+DP  PNMM D  KLLSA+CI+ + E + E VLEA+T   E  +++R
Sbjct: 1    MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGE-ESILEEVLEALTSAGEEKKIDR 59

Query: 286  FQPLLDGLKSGTTIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQDLREIE 345
            F  +++GL+  + + L+V C+QLINAL+T  ++LDFR+HIR+E MR GL ++L +L+ I+
Sbjct: 60   FFCIVEGLRHNS-VQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIK 118

Query: 346  NEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSIL 405
            N+ + +QL VFDE  EED ++L  RL+DIR E+D+  +V+ ++ +TVK+++AE +F+SIL
Sbjct: 119  NDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISIL 178

Query: 406  QHLLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDFKCRHLQIEIEGLIDQMIDKTKV 465
            QHLLL+RNDY  R QY+KLI+EC+SQIVLH++G DPDF  R                   
Sbjct: 179  QHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYR------------------- 219

Query: 466  EKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIATEK 525
                       K+LD +LT   ++ ++  K+E +FE+K  +       L+ + ++  T+ 
Sbjct: 220  -----------KRLDLDLTQFVDICIDQAKLE-EFEEKASE-------LYKKFEKEFTDH 260

Query: 526  QDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGT 585
            Q+ +A       E+ K   ++ + + E+ +  +                    LP D   
Sbjct: 261  QETQA-------ELQKKEAKINELQAELQAFKSQF----------------GALPADCNI 297

Query: 586  IIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPP 645
                                 P PP   GG          G +A+ PPPPL     +PPP
Sbjct: 298  ---------------------PLPPSKEGGT---------GHSALPPPPPLPSGGGVPPP 327

Query: 646  PPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMP 705
            PP                   PPPPPLPG          +P S  +PPP           
Sbjct: 328  PP------------------PPPPPPLPGMR--------MPFSGPVPPP----------- 350

Query: 706  PPPPPLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPKKLYK 765
                         PP  F GG   PP                    P+LPFGL PKK +K
Sbjct: 351  -------------PPLGFLGGQNSPP-------------------LPILPFGLKPKKEFK 378

Query: 766  PEVQLRRPNWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKDQEG 825
            PE+ +RR NW K+   +++++CFW KV E+++EN +L  KL  TF  Q    K ++++E 
Sbjct: 379  PEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQ---QKERREEED 435

Query: 826  GEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNL 885
             EEKKS+ KKK+KELK LDSK AQNLSIFL SFR+PY+EI+ +ILEV+E  L ESMIQNL
Sbjct: 436  IEEKKSI-KKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNL 494

Query: 886  IKQMPEPEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIK 945
            IK +P+ EQL  LS+ K EY +L E EQF VVM  V RLRPRL+AILFKLQF EQV NIK
Sbjct: 495  IKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIK 554

Query: 946  PEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTD 1005
            P+I++V+ ACEE++KS+SFS LLE+ LL+GNYMNAGSRNA  FGFN+S LCKL+DTKS D
Sbjct: 555  PDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSAD 614

Query: 1006 QKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQ 1065
            QK TLLHFL E+CE  YPD+L F D+L  ++KAS+VS E L+KNL QM +Q+  +E++++
Sbjct: 615  QKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELE 674

Query: 1066 NFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEF 1125
             FP   D  DKFV KM+ FV  A+EQY  L  +H NME LY+ +  Y+  D KK+SVE+F
Sbjct: 675  TFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVEDF 734

Query: 1126 FMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGD 1185
              DL+NFR  F+QA+KEN K+RE EEK +R ++AKE AE+ERLE+QQK+++L++M  EGD
Sbjct: 735  LTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEGD 794

Query: 1186 ETGVMDSLLEALQSGAAF--RRKRGP 1209
            ETGVMD+LLEALQSGAAF  RRKR P
Sbjct: 795  ETGVMDNLLEALQSGAAFRDRRKRTP 820


>gi|21071077 dishevelled-associated activator of morphogenesis 1 [Homo
            sapiens]
          Length = 1078

 Score =  396 bits (1018), Expect = e-110
 Identities = 320/1170 (27%), Positives = 548/1170 (46%), Gaps = 197/1170 (16%)

Query: 81   EQVLVLFEQMLLDMNLNEEKQQPLREKDIIIKREMVSQYLYTSKAGMSQKESSKS-AMMY 139
            E++ V+F +++ +++L ++     RE    +  E   Q   + K    + + + S    Y
Sbjct: 51   EELDVMFSELVDELDLTDKH----REAMFALPAEKKWQIYCSKKKDQEENKGATSWPEFY 106

Query: 140  IQELRSGLRDMPLLSC-----------LESLRVSLNNNPVSWVQTF-GAEGLASLLDILK 187
            I +L S      LL+            +ESL+ +L   P+ +V  F   +GL+ +L+ LK
Sbjct: 107  IDQLNSMAARKSLLALEKEEEEERSKTIESLKTALRTKPMRFVTRFIDLDGLSCILNFLK 166

Query: 188  RLHDEKEETAGSYDSRNKHEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMM 247
             +  E  E      SR    +I C+KA MNN  G   +L   E I ++ +++        
Sbjct: 167  TMDYETSE------SRIHTSLIGCIKALMNNSQGRAHVLAHSESINVIAQSLSTENIKTK 220

Query: 248  IDAAKLLSALCILPQPEDMNERVLEAMTERAEM-DEVERFQPLLDGLKSGT-----TIAL 301
            +   ++L A+C++P     +++VL+AM    +   E  RFQ L++ L   T      ++L
Sbjct: 221  VAVLEILGAVCLVPGG---HKKVLQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVSL 277

Query: 302  KVGCLQLINALITPA---EELDFRVHIRSELMRLGLHQVLQDLREIENEDMRVQLNVFDE 358
            K   +  INA+++     E LDFR+H+R E + LG+  V+  LRE EN  +   L+ F+ 
Sbjct: 278  KTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEM 337

Query: 359  QGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEAR 418
               ED  +   R + + ++     ++F++    +  S+A PHF+SIL H L +       
Sbjct: 338  LRNEDELEFAKRFELVHIDTKSATQMFELTRKRLTHSEAYPHFMSILHHCLQMPYKRSGN 397

Query: 419  P-QYYKLIEECISQIVLHKN-GADPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELE 476
              QY+ L++  I QIV+  + G DPD         I+ ++  ++++ +V++ + +A ++ 
Sbjct: 398  TVQYWLLLDRIIQQIVIQNDKGQDPDSTPLE-NFNIKNVVRMLVNENEVKQWKEQAEKMR 456

Query: 477  KKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLT 536
            K+        +ELQ +++K E + + K Q+ +     L+  K+++  E      E  Q+ 
Sbjct: 457  KE-------HNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKET----TEHKQVK 505

Query: 537  GEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDS 596
             +VA LT +L +  +     S                             IP  P+PG  
Sbjct: 506  QQVADLTAQLHELSRRAVCAS-----------------------------IPGGPSPG-- 534

Query: 597  TTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPS 656
                            PGG     P S+PG             + +PPPP          
Sbjct: 535  ---------------APGG---PFPSSVPG-------------SLLPPPP---------- 553

Query: 657  PSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPG 716
                        PPPLPG   +PPPPPPLP     P  PPP       PP PPPL     
Sbjct: 554  ------------PPPLPG-GMLPPPPPPLP-----PGGPPP-------PPGPPPL----- 583

Query: 717  IPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWS 776
                     G  +PPP   MG+                   L  K + +P   L+  NWS
Sbjct: 584  ---------GAIMPPPGAPMGL------------------ALKKKSIPQPTNALKSFNWS 616

Query: 777  KLVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTK------TSKAKKDQEGGEEKK 830
            KL  E+  +   WT++ + +         L  TFSA  +       S +K+ +    +  
Sbjct: 617  KL-PENKLEGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQDFFVNSNSKQKEADAIDDT 675

Query: 831  SVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAV-LTESMIQNLIKQM 889
               K KVKEL V+D + AQN +I L   ++   EIK  IL ++E   L + M++ L+K +
Sbjct: 676  LSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFV 735

Query: 890  PEPEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIV 949
            PE   + +L E K E D +A++++F   M  +   + RL ++ FK +F+E+V  +KP++ 
Sbjct: 736  PEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVE 795

Query: 950  SVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKST-DQKM 1008
            ++ +  EE+ +S +   LLE+ L  GNYMN G R   A+GF IS L K+ DTKS+ D+ +
Sbjct: 796  AIRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQR-GNAYGFKISSLNKIADTKSSIDKNI 854

Query: 1009 TLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFP 1068
            TLLH+L  + EN YP VL   +EL  + +A++V+   L K +  ++  +  VE +++   
Sbjct: 855  TLLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELDKEISTLRSGLKAVETELEYQK 914

Query: 1069 AATDEK-DKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFM 1127
            +   +  DKFV  ++ F+  A   ++ +  + +  + L+ +  ++F  +  K+  +EFF 
Sbjct: 915  SQPPQPGDKFVSVVSQFITVASFSFSDVEDLLAEAKDLFTKAVKHFGEEAGKIQPDEFFG 974

Query: 1128 DLHNFRNMFLQAVKENQK-RRETEEKMRRAKL-AKEKAEKERLEKQQKREQLIDMNAEGD 1185
                F     +A +EN+  R++ EE+ RRA++ A+ K ++ER  K +K ++        +
Sbjct: 975  IFDQFLQAVSEAKQENENMRKKKEEEERRARMEAQLKEQRERERKMRKAKE------NSE 1028

Query: 1186 ETGVMDSLLEALQSGAAFRRKRGPRQANRK 1215
            E+G  D L+ AL+SG  F +     + NRK
Sbjct: 1029 ESGEFDDLVSALRSGEVFDKDLSKLKRNRK 1058


>gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]
          Length = 1240

 Score =  339 bits (870), Expect = 9e-93
 Identities = 302/1095 (27%), Positives = 497/1095 (45%), Gaps = 148/1095 (13%)

Query: 142  ELRSGLRDMPLLSCLESLRVSLNNNPVSW-VQTFGAEGLASLLDILKRLHDEKEETAGSY 200
            EL   L  MP +     LR  L  +   W VQ     GL  LL+ L RL       A   
Sbjct: 36   ELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRG--VARIS 93

Query: 201  DSRNKHEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMIDAAKLLSALCIL 260
            D+  +   + C++A MN++ GI+ +L  +  +  L +A+D +   +     +LL+ALCI 
Sbjct: 94   DALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIY 153

Query: 261  PQPEDMNERVLEAMTE-RAEMDEVERFQPLLDGLKSGTTIALKVGCLQLINALITPAEEL 319
              PE  +   L+A+   +    +  RF  +++ L     +   V  L +INA+I   E+L
Sbjct: 154  -SPEG-HVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPEDL 211

Query: 320  DFRVHIRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMD 379
              R  +R+E + L L  VL  LR++E+ D+ +QL  F+E   ED  +L      +  +M 
Sbjct: 212  RARTQLRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGV--DMS 269

Query: 380  DFNEVFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGA 439
               EVF  L + V  S      LS                         + Q +LH    
Sbjct: 270  SHQEVFASLFHKVSCSPVSAQLLS-------------------------VLQGLLH---L 301

Query: 440  DPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESD 499
            +P  +   L  E    ++ ++++  +  S+A+   LE+ ++  L+      V+ +   S 
Sbjct: 302  EPTLRSSQLLWEA---LESLVNRAVLLASDAQECTLEEVVERLLS------VKGRPRPSP 352

Query: 500  FEQKLQDLQGEKDALH--SEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLS 557
              +  + +Q   D     S  Q   T K  +E +        A   + ++ A+ E    S
Sbjct: 353  LVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPA----AAAACEPVDHAQSE----S 404

Query: 558  AAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVC 617
               ++ P ++  +A                         +TPPPPPPPP           
Sbjct: 405  ILKVSQPRALEQQA-------------------------STPPPPPPPP----------- 428

Query: 618  ISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSAR 677
                  LPG +A  PPPP        PPPPLP  VG     +LP     PPPPPLPG   
Sbjct: 429  -----LLPGSSAEPPPPP--------PPPPLPS-VGA---KALP---TAPPPPPLPGLGA 468

Query: 678  IPPP----PPPLPGSAG-IPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPP 732
            + PP    PPPLPGS   +PPPPPPLPG    PPPPP LPG    PPPPP P  P    P
Sbjct: 469  MAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSP 528

Query: 733  PPGMGMPP----PPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKLVAEDLSQ-DC 787
            P   GM          G G    P      + +++  P +++++ NW KL +    + + 
Sbjct: 529  PVAGGMEEVIVAQVDHGLGSAWVP------SHRRVNPPTLRMKKLNWQKLPSNVAREHNS 582

Query: 788  FWTKVKEDRFENNEL-FAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSK 846
             W  +     E  E  F+ +   FS       AK  +      ++  +K+ KE+  LD+K
Sbjct: 583  MWASLSSPDAEAVEPDFSSIERLFSFPA----AKPKEPTMVAPRA--RKEPKEITFLDAK 636

Query: 847  TAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKDEYD 906
             + NL+IFL  F+   +E+  +I   +       +++ L+K +PE  +++ L    +E  
Sbjct: 637  KSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERA 696

Query: 907  DLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSN 966
             LA ++ F +++  +P  + R+  +L     +  ++ ++P+   V AACE L  S     
Sbjct: 697  KLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPI 756

Query: 967  LLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVL 1026
              ++ L +GN++N GS    A GF IS L KL +TKS   ++TLLH + E  E  +PD+L
Sbjct: 757  FCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLL 816

Query: 1027 KFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVK 1086
            + P +L    +A+ ++ E ++       K++ + ER V    +  + ++++ E++ + + 
Sbjct: 817  QLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVS--ASVAEVQEQYTERLQASI- 873

Query: 1087 DAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKR 1146
                 +  L  +   +E   +EL +Y   D ++LS+E+ F  +  FR++FL+A+KEN+ R
Sbjct: 874  ---SAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDR 930

Query: 1147 RETEEKMRRAK--LAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFR 1204
            +E   K  R K  LA+E+A + R E  +   +      + +E  V+D+LL  ++ G   R
Sbjct: 931  KEQAAKAERRKQQLAEEEARRPRGEDGKPVRK---GPGKQEEVCVIDALLADIRKGFQLR 987

Query: 1205 ---RKRGPRQANRKA 1216
               R RG      KA
Sbjct: 988  KTARGRGDTDGGSKA 1002


>gi|149999380 inverted formin 2 isoform 1 [Homo sapiens]
          Length = 1249

 Score =  339 bits (870), Expect = 9e-93
 Identities = 302/1095 (27%), Positives = 497/1095 (45%), Gaps = 148/1095 (13%)

Query: 142  ELRSGLRDMPLLSCLESLRVSLNNNPVSW-VQTFGAEGLASLLDILKRLHDEKEETAGSY 200
            EL   L  MP +     LR  L  +   W VQ     GL  LL+ L RL       A   
Sbjct: 36   ELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRG--VARIS 93

Query: 201  DSRNKHEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMIDAAKLLSALCIL 260
            D+  +   + C++A MN++ GI+ +L  +  +  L +A+D +   +     +LL+ALCI 
Sbjct: 94   DALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIY 153

Query: 261  PQPEDMNERVLEAMTE-RAEMDEVERFQPLLDGLKSGTTIALKVGCLQLINALITPAEEL 319
              PE  +   L+A+   +    +  RF  +++ L     +   V  L +INA+I   E+L
Sbjct: 154  -SPEG-HVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPEDL 211

Query: 320  DFRVHIRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMD 379
              R  +R+E + L L  VL  LR++E+ D+ +QL  F+E   ED  +L      +  +M 
Sbjct: 212  RARTQLRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGV--DMS 269

Query: 380  DFNEVFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGA 439
               EVF  L + V  S      LS                         + Q +LH    
Sbjct: 270  SHQEVFASLFHKVSCSPVSAQLLS-------------------------VLQGLLH---L 301

Query: 440  DPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESD 499
            +P  +   L  E    ++ ++++  +  S+A+   LE+ ++  L+      V+ +   S 
Sbjct: 302  EPTLRSSQLLWEA---LESLVNRAVLLASDAQECTLEEVVERLLS------VKGRPRPSP 352

Query: 500  FEQKLQDLQGEKDALH--SEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLS 557
              +  + +Q   D     S  Q   T K  +E +        A   + ++ A+ E    S
Sbjct: 353  LVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPA----AAAACEPVDHAQSE----S 404

Query: 558  AAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVC 617
               ++ P ++  +A                         +TPPPPPPPP           
Sbjct: 405  ILKVSQPRALEQQA-------------------------STPPPPPPPP----------- 428

Query: 618  ISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSAR 677
                  LPG +A  PPPP        PPPPLP  VG     +LP     PPPPPLPG   
Sbjct: 429  -----LLPGSSAEPPPPP--------PPPPLPS-VGA---KALP---TAPPPPPLPGLGA 468

Query: 678  IPPP----PPPLPGSAG-IPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPP 732
            + PP    PPPLPGS   +PPPPPPLPG    PPPPP LPG    PPPPP P  P    P
Sbjct: 469  MAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSP 528

Query: 733  PPGMGMPP----PPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKLVAEDLSQ-DC 787
            P   GM          G G    P      + +++  P +++++ NW KL +    + + 
Sbjct: 529  PVAGGMEEVIVAQVDHGLGSAWVP------SHRRVNPPTLRMKKLNWQKLPSNVAREHNS 582

Query: 788  FWTKVKEDRFENNEL-FAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSK 846
             W  +     E  E  F+ +   FS       AK  +      ++  +K+ KE+  LD+K
Sbjct: 583  MWASLSSPDAEAVEPDFSSIERLFSFPA----AKPKEPTMVAPRA--RKEPKEITFLDAK 636

Query: 847  TAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKDEYD 906
             + NL+IFL  F+   +E+  +I   +       +++ L+K +PE  +++ L    +E  
Sbjct: 637  KSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERA 696

Query: 907  DLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSN 966
             LA ++ F +++  +P  + R+  +L     +  ++ ++P+   V AACE L  S     
Sbjct: 697  KLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPI 756

Query: 967  LLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVL 1026
              ++ L +GN++N GS    A GF IS L KL +TKS   ++TLLH + E  E  +PD+L
Sbjct: 757  FCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLL 816

Query: 1027 KFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVK 1086
            + P +L    +A+ ++ E ++       K++ + ER V    +  + ++++ E++ + + 
Sbjct: 817  QLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVS--ASVAEVQEQYTERLQASI- 873

Query: 1087 DAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKR 1146
                 +  L  +   +E   +EL +Y   D ++LS+E+ F  +  FR++FL+A+KEN+ R
Sbjct: 874  ---SAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDR 930

Query: 1147 RETEEKMRRAK--LAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFR 1204
            +E   K  R K  LA+E+A + R E  +   +      + +E  V+D+LL  ++ G   R
Sbjct: 931  KEQAAKAERRKQQLAEEEARRPRGEDGKPVRK---GPGKQEEVCVIDALLADIRKGFQLR 987

Query: 1205 ---RKRGPRQANRKA 1216
               R RG      KA
Sbjct: 988  KTARGRGDTDGGSKA 1002


>gi|160707881 formin 2 [Homo sapiens]
          Length = 1722

 Score =  318 bits (816), Expect = 2e-86
 Identities = 244/693 (35%), Positives = 339/693 (48%), Gaps = 120/693 (17%)

Query: 556  LSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPP-------PPPP-- 606
            L  A I  PP +P  A +PP PPLPG    I PPPP PG    PPPP       PPPP  
Sbjct: 1036 LPGAGIPPPPPLPG-AGIPPPPPLPGAG--IPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1092

Query: 607  ----PPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPG 662
                PPPPPLPG V I  PP LPG   I PPPPL G A IPPPPPLP G GIP P  LP 
Sbjct: 1093 GAGIPPPPPLPG-VGIPPPPPLPGA-GIPPPPPLPG-AGIPPPPPLP-GAGIPPPPPLP- 1147

Query: 663  GTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPP 722
               IPPPPPLPG+    PPPPPLPG AGI PPPPPLPG  G+ PPPPPLP G GIPPPPP
Sbjct: 1148 RVGIPPPPPLPGAG--IPPPPPLPG-AGI-PPPPPLPG-VGI-PPPPPLP-GVGIPPPPP 1200

Query: 723  FPGGPGIPPPP--PGMGMPPP-----PPFGFGVPAAPVLP-------------------- 755
             PG  GIPPPP  PGMG+PP      PP G G+P  P+LP                    
Sbjct: 1201 LPGA-GIPPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQV 1259

Query: 756  ------------FGL-------TPKKLYKPEVQLRRPNWSKL---VAEDLSQDCFWTKVK 793
                        FGL       + K+  +P   ++   W+++      D S    W K++
Sbjct: 1260 CGFLPPPLPSGLFGLGMNQDKGSRKQPIEPCRPMKPLYWTRIQLHSKRDSSTSLIWEKIE 1319

Query: 794  E---DRFENNELFAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKE-LKVLDSKTAQ 849
            E   D  E  ELF+K        T   + KK         ++ K K K+ +K+L +K +Q
Sbjct: 1320 EPSIDCHEFEELFSK--------TAVKERKK-----PISDTISKTKAKQVVKLLSNKRSQ 1366

Query: 850  NLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKML------SELKD 903
             + I + S  +  ++I++ ++ ++ +V+    +Q L +   + ++L+ +      S+ K+
Sbjct: 1367 AVGILMSSLHLDMKDIQHAVVNLDNSVVDLETLQALYENRAQSDELEKIEKHGRSSKDKE 1426

Query: 904  EYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSES 963
                L + EQF   +  +P    R+  ILF+  FSE + +I+ ++  +   CE L+    
Sbjct: 1427 NAKSLDKPEQFLYELSLIPNFSERVFCILFQSTFSESICSIRRKLELLQKLCETLKNGPG 1486

Query: 964  FSNLLEITLLVGNYMNAGSRNAG-AFGFNISFLCKLRDTKSTDQKMTLL-----HFLAEL 1017
               +L + L  GNYMN G++  G A GF +  L KL+D KS+D   +LL     ++L   
Sbjct: 1487 VMQVLGLVLAFGNYMNGGNKTRGQADGFGLDILPKLKDVKSSDNSRSLLSYIVSYYLRNF 1546

Query: 1018 CENDYPDVLKFP-DELAHVEKASRVSAENLQKNLDQMKKQIS--DVERDVQNFPAATDEK 1074
             E+   +   FP  E   + +AS++  E+ QK+L ++KK +   +VE       ++ +  
Sbjct: 1547 DEDAGKEQCLFPLPEPQDLFQASQMKFEDFQKDLRKLKKDLKACEVEAGKVYQVSSKEHM 1606

Query: 1075 DKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDP----KKLSVEEFFMDLH 1130
              F E M  F+  A+          +     + E   YF   P    K++S   FF   H
Sbjct: 1607 QPFKENMEQFIIQAKIDQEAEENSLTETHKCFLETTAYFFMKPKLGEKEVSPNAFFSIWH 1666

Query: 1131 NFRNMFLQAVKENQKR------RETEEKMRRAK 1157
             F + F    K+  K       +E EE  R+ K
Sbjct: 1667 EFSSDFKDFWKKENKLLLQERVKEAEEVCRQKK 1699



 Score =  224 bits (572), Expect = 3e-58
 Identities = 133/211 (63%), Positives = 141/211 (66%), Gaps = 22/211 (10%)

Query: 556  LSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPP--PPPPPLP 613
            L  A I +PP +P  A +PP PPLPG    I PPPP PG    PPPP P    PPPPPLP
Sbjct: 959  LPGAGIPLPPPLPG-AGIPPPPPLPGAG--IPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1015

Query: 614  GGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLP 673
            G   I  PP LPG   I PPPPL G A IPPPPPLP G GIP P  LP G  IPPPPPLP
Sbjct: 1016 GAG-IPPPPPLPGA-GIPPPPPLPG-AGIPPPPPLP-GAGIPPPPPLP-GAGIPPPPPLP 1070

Query: 674  GSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPP 733
            G+    PPPPPLPG AGI PPPPPLPG AG+ PPPPPLP G GIPPPPP PG  GIPPPP
Sbjct: 1071 GAG--IPPPPPLPG-AGI-PPPPPLPG-AGI-PPPPPLP-GVGIPPPPPLPGA-GIPPPP 1122

Query: 734  --PGMGMPPPPPF-GFGVPAAPVLP-FGLTP 760
              PG G+PPPPP  G G+P  P LP  G+ P
Sbjct: 1123 PLPGAGIPPPPPLPGAGIPPPPPLPRVGIPP 1153



 Score =  223 bits (567), Expect = 1e-57
 Identities = 138/235 (58%), Positives = 145/235 (61%), Gaps = 34/235 (14%)

Query: 556  LSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIP-PPPAPGDSTTPPPP-------PPPP- 606
            L  A I  PP +P  A +PP PPLPG     IP PPP PG    PPPP       PPPP 
Sbjct: 937  LPGAGIPPPPPLPGAA-IPPPPPLPGAG---IPLPPPLPGAGIPPPPPLPGAGIPPPPPL 992

Query: 607  -----PPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLP 661
                 PPPPPLPG   I  PP LPG   I PPPPL G A IPPPPPLP G GIP P  LP
Sbjct: 993  PGAGIPPPPPLPGAG-IPPPPPLPGA-GIPPPPPLPG-AGIPPPPPLP-GAGIPPPPPLP 1048

Query: 662  GGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPP 721
            G   IPPPPPLPG+    PPPPPLPG AGIPPPPP LPG AG+PPPPP LPG  GIPPPP
Sbjct: 1049 GA-GIPPPPPLPGAGI--PPPPPLPG-AGIPPPPP-LPG-AGIPPPPP-LPGA-GIPPPP 1100

Query: 722  PFPGGPGIPPPPP--GMGMPPPPPF-GFGVPAAPVLPFGLTPKKLYKPEVQLRRP 773
            P PG  GIPPPPP  G G+PPPPP  G G+P  P LP    P     P V +  P
Sbjct: 1101 PLPG-VGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPP 1154



 Score =  219 bits (557), Expect = 2e-56
 Identities = 131/215 (60%), Positives = 139/215 (64%), Gaps = 21/215 (9%)

Query: 564  PPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPP--PPPPPLPGGVCISSP 621
            PP +P  A +PP PPLPG    I+P PP PG    PPPP P    PPPPPLP G  I  P
Sbjct: 912  PPPLPG-AGIPPPPPLPG--AGILPLPPLPGAGIPPPPPLPGAAIPPPPPLP-GAGIPLP 967

Query: 622  PSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPP 681
            P LP G  I PPPPL G A IPPPPPLP G GIP P  LP G  IPPPPPLPG+    PP
Sbjct: 968  PPLP-GAGIPPPPPLPG-AGIPPPPPLP-GAGIPPPPPLP-GAGIPPPPPLPGAG--IPP 1021

Query: 682  PPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPP--PGMGMP 739
            PPPLPG AGI PPPPPLPG AG+ PPPPPLPG  GIPPPPP PG  GIPPPP  PG G+P
Sbjct: 1022 PPPLPG-AGI-PPPPPLPG-AGI-PPPPPLPGA-GIPPPPPLPGA-GIPPPPPLPGAGIP 1075

Query: 740  PPPPF-GFGVPAAPVLPFGLTPKKLYKPEVQLRRP 773
            PPPP  G G+P  P LP    P     P V +  P
Sbjct: 1076 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPP 1110



 Score =  212 bits (539), Expect = 2e-54
 Identities = 126/215 (58%), Positives = 132/215 (61%), Gaps = 44/215 (20%)

Query: 574  PPAPPLPGDSGTIIP------PPPAPGDSTTPPPPPPPP----PPPPPLPG--------- 614
            PP PPLPG +   +P      PPP  G    PPPPPP P    PPPPPLPG         
Sbjct: 878  PPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPL 937

Query: 615  -GVCISSPPSLPGGTAISPPPPLSG----------DATIPPPPPLPEGVGIPSPSSLPGG 663
             G  I  PP LPG  AI PPPPL G           A IPPPPPLP G GIP P  LP G
Sbjct: 938  PGAGIPPPPPLPGA-AIPPPPPLPGAGIPLPPPLPGAGIPPPPPLP-GAGIPPPPPLP-G 994

Query: 664  TAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPF 723
              IPPPPPLPG+    PPPPPLPG AGI PPPPPLPG AG+ PPPPPLPG  GIPPPPP 
Sbjct: 995  AGIPPPPPLPGAG--IPPPPPLPG-AGI-PPPPPLPG-AGI-PPPPPLPGA-GIPPPPPL 1047

Query: 724  PGGPGIPPPP--PGMGMPPPPPF-GFGVPAAPVLP 755
            PG  GIPPPP  PG G+PPPPP  G G+P  P LP
Sbjct: 1048 PGA-GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1081



 Score =  204 bits (519), Expect = 4e-52
 Identities = 125/218 (57%), Positives = 134/218 (61%), Gaps = 40/218 (18%)

Query: 566  SVPSRAPVP---PAPPLPGDSGTIIPPPPAPG------DSTTPPPPPP------PPPPPP 610
            ++PS  P+P    +  +PG      PPPP PG       ST  P PPP       PPPPP
Sbjct: 854  NIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPP 913

Query: 611  PLPGGVCISSPPSLPG----------GTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSL 660
            PLP G  I  PP LPG          G  I PPPPL G A IPPPPPLP G GIP P  L
Sbjct: 914  PLP-GAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPG-AAIPPPPPLP-GAGIPLPPPL 970

Query: 661  PGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPP 720
            P G  IPPPPPLPG+    PPPPPLPG AGI PPPPPLPG AG+ PPPPPLPG  GIPPP
Sbjct: 971  P-GAGIPPPPPLPGAG--IPPPPPLPG-AGI-PPPPPLPG-AGI-PPPPPLPGA-GIPPP 1022

Query: 721  PPFPGGPGIPPPP--PGMGMPPPPPF-GFGVPAAPVLP 755
            PP PG  GIPPPP  PG G+PPPPP  G G+P  P LP
Sbjct: 1023 PPLPGA-GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1059



 Score =  160 bits (405), Expect = 7e-39
 Identities = 135/416 (32%), Positives = 165/416 (39%), Gaps = 137/416 (32%)

Query: 470  AKAAELEKKLDSELTARHELQVEMKKMESDFEQK-LQDLQGEKDA-----LHSEKQQIAT 523
            +K  + E +L+   T       E  +  SD  QK + D++ E  A     L    + + T
Sbjct: 629  SKPPDEEHRLEDAETESQSAVSETPQKRSDAVQKEVVDMKSEGQATVIQQLEQTIEDLRT 688

Query: 524  EKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPL---P 580
            +  +LE +   L  EVA   + LE+       +   A+ +         +  A  +   P
Sbjct: 689  KIAELERQYPALDTEVASGHQGLENGVTASGDVCLEALRLEEKEVRHHRILEAKSIQTSP 748

Query: 581  GDSGTIIPPPPAPGDSTTPPPPP------------------------------------P 604
             + G ++  PP  G    PP PP                                     
Sbjct: 749  TEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSIS 808

Query: 605  PPPPPPPL--------PGG----------------------------------VCISSPP 622
             PPPPP L        PG                                    C  S  
Sbjct: 809  QPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSS 868

Query: 623  SLPGGTAISP--------------------PPPLSGDATIPPPPPLPEGVGIPSPSSLPG 662
            S+PG   + P                    PPPL G   +PPPPP   G GIP P  LPG
Sbjct: 869  SMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPG 928

Query: 663  ----------GTAIPPPPPLPGSARIPPPPPPLPGSAGIP----------PPPPPLPGEA 702
                      G  IPPPPPLPG+A   PPPPPLPG AGIP          PPPPPLPG A
Sbjct: 929  AGILPLPPLPGAGIPPPPPLPGAA--IPPPPPLPG-AGIPLPPPLPGAGIPPPPPLPG-A 984

Query: 703  GMPPPPPPLPGGPGIPPPPPFPGGPGIPPPP--PGMGMPPPPPF-GFGVPAAPVLP 755
            G+ PPPPPLPG  GIPPPPP PG  GIPPPP  PG G+PPPPP  G G+P  P LP
Sbjct: 985  GI-PPPPPLPGA-GIPPPPPLPGA-GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1037



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 54/217 (24%), Positives = 73/217 (33%), Gaps = 30/217 (13%)

Query: 522 ATEKQDLEAEVSQLTG----EVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPA- 576
           ATE++DL +++ Q       +  +L  +L+  +++     A     PP+  S  P P A 
Sbjct: 189 ATEQEDLLSDIQQAIRLQQQQQQQLQLQLQQQQQQQQLQGAEEPAAPPTAVS--PQPGAF 246

Query: 577 ----PPLPGDSGTIIPPPPAP---------GDSTTPPPPPPPPPPPPPLPGGVCISSPPS 623
                 L G SG     P +P          D        P  P  PP PGG+ +S  PS
Sbjct: 247 LGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPREPQQPPSPGGLPVSEAPS 306

Query: 624 LPGGTAISPPPPLSGDATIPPPPPLPEGVGIP------SPSSLPGGTAIPPPPPLPGSAR 677
           LP     +   P S     P   P  E  G P      +            P   PG   
Sbjct: 307 LPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSPGEEW 366

Query: 678 IPPPPPPLPGSAGIPPPP----PPLPGEAGMPPPPPP 710
            P      P   G  P      P  P  A +P  P P
Sbjct: 367 APEVGEDAPQRLGEEPEEEAQGPDAPAAASLPGSPAP 403



 Score = 30.8 bits (68), Expect = 8.6
 Identities = 29/111 (26%), Positives = 36/111 (32%), Gaps = 15/111 (13%)

Query: 653 GIPSPSSLPGGTAIPPPP------------PLPGSARIPPPPPPLPGSAGIPPPPPPLPG 700
           G   P++ P  TA+ P P            P  G+   P  P      + +   P  L  
Sbjct: 228 GAEEPAAPP--TAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAA 285

Query: 701 EAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAA 751
           E    P  PP PGG  +   P  P         P     P P  G G  AA
Sbjct: 286 EP-REPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAA 335


>gi|40548415 dishevelled associated activator of morphogenesis 2 [Homo
            sapiens]
          Length = 1067

 Score =  263 bits (672), Expect = 8e-70
 Identities = 178/568 (31%), Positives = 294/568 (51%), Gaps = 40/568 (7%)

Query: 679  PPPPPPLPGSAG-----IPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPP 733
            PPP  PL  S+      +PPPPPPLP     PPPPPPLP  PG PP PP        PP 
Sbjct: 523  PPPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLP--PGGPPTPPGA------PPC 574

Query: 734  PGMGMP-PPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKLVAEDLSQDCFWTKV 792
             GMG+P P  P+       P     L  K++ +P   L+  NW KL  E+      W ++
Sbjct: 575  LGMGLPLPQDPY-------PSSDVPLRKKRVPQPSHPLKSFNWVKL-NEERVPGTVWNEI 626

Query: 793  KED---RFENNELFAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQ 849
             +    R  + E F K+   FSA  +  K    + G  E   +  +KVKEL V+D + AQ
Sbjct: 627  DDMQVFRILDLEDFEKM---FSAYQRHQK----ELGSTEDIYLASRKVKELSVIDGRRAQ 679

Query: 850  NLSIFLGSFRMPYQEIKNVILEVNEAV-LTESMIQNLIKQMPEPEQLKMLSELKDEYDDL 908
            N  I L   ++  +EI+  IL+++E   L + M++ L+K +PE   + +L E K E + +
Sbjct: 680  NCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERM 739

Query: 909  AESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLL 968
            A +++F   M  +   + RL A+ FK +F E++   KP++ ++  A  EL +S+    +L
Sbjct: 740  ARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELVRSKRLRQML 799

Query: 969  EITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKST-DQKMTLLHFLAELCENDYPDVLK 1027
            E+ L +GN+MN G R  GA+GF ++ L K+ DTKS+ D+ ++LLH+L  + E  +PD+L 
Sbjct: 800  EVILAIGNFMNKGQR-GGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILN 858

Query: 1028 FPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKD 1087
             P EL H+ +A++V+   L+K +  +++ +  VE          +  DKFV  M+ F+  
Sbjct: 859  MPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVLEYQRRQVREPSDKFVPVMSDFITV 918

Query: 1088 AQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKE-NQKR 1146
            +   +++L    +     + +   +F     K+  +EFF     F   F +A ++    R
Sbjct: 919  SSFSFSELEDQLNEARDKFAKALMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQDLEAMR 978

Query: 1147 RETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFRRK 1206
            R  EE+ RRA++     E+   E+ Q++ +++   +  +E G  D L+ AL+SG  F + 
Sbjct: 979  RRKEEEERRARMEAMLKEQRERERWQRQRKVLAAGSSLEEGGEFDDLVSALRSGEVFDKD 1038

Query: 1207 RGPRQANRKAGCAVTSLLASELTKDDAM 1234
                + +RK     +   A E+T++ A+
Sbjct: 1039 LCKLKRSRKR----SGSQALEVTRERAI 1062



 Score =  173 bits (439), Expect = 8e-43
 Identities = 139/506 (27%), Positives = 238/506 (47%), Gaps = 61/506 (12%)

Query: 156 LESLRVSLNNNPVSWVQTF-GAEGLASLLDILKRLHDEKEETAGSYDSRNKHEIIRCLKA 214
           +E L+ +L   P+ +V  F   EGL  LL+ L+ +         + +SR    +I C+KA
Sbjct: 130 VEDLKTALRTQPMRFVTRFIELEGLTCLLNFLRSMDH------ATCESRIHTSLIGCIKA 183

Query: 215 FMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAM 274
            MNN  G   +L   E I  + +++        +   ++L A+C++P     +++VL+AM
Sbjct: 184 LMNNSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGG---HKKVLQAM 240

Query: 275 TE-RAEMDEVERFQPLLDGLKSGT-----TIALKVGCLQLINALITPA---EELDFRVHI 325
              +    E  RFQ LL+ L          + LK   +  INA++      + L+FR+H+
Sbjct: 241 LHYQVYAAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHL 300

Query: 326 RSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVF 385
           R E + LG+  V+  LR+ EN  +   L+ F+    ED  +L  R D + ++    +++F
Sbjct: 301 RYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMF 360

Query: 386 QILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYY---KLIEECISQIVLH-KNGADP 441
           +++   +K ++A P  LS+L H L  +  Y+    Y+   +L++  + QIVL  + G DP
Sbjct: 361 ELIHKKLKYTEAYPCLLSVLHHCL--QMPYKRNGGYFQQWQLLDRILQQIVLQDERGVDP 418

Query: 442 DFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFE 501
           D         ++ +++ +I++ +V++   +A +  K+         EL   +++ E + E
Sbjct: 419 DLAPLE-NFNVKNIVNMLINENEVKQWRDQAEKFRKE-------HMELVSRLERKERECE 470

Query: 502 QKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAI 561
            K  + +     L+  K ++A E Q+L     Q  G+VA+L  +L +       LS   +
Sbjct: 471 TKTLEKEEMMRTLNKMKDKLARESQELR----QARGQVAELVAQLSE-------LSTGPV 519

Query: 562 TVPPSVPSRAPVPPAPPLPGDSGTII-----PPPPAPGDSTTPPPPPPPPPPPPPLPGGV 616
           + PP        PP  PL   S         PPPP P     PPPPPP PP  PP P G 
Sbjct: 520 SSPP--------PPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPPTPPG- 570

Query: 617 CISSPPSLPGGTAISPPPPLSGDATI 642
              +PP L  G  +   P  S D  +
Sbjct: 571 ---APPCLGMGLPLPQDPYPSSDVPL 593


>gi|33356148 formin-like 1 [Homo sapiens]
          Length = 1100

 Score =  232 bits (592), Expect = 1e-60
 Identities = 207/808 (25%), Positives = 368/808 (45%), Gaps = 114/808 (14%)

Query: 448  LQIEIEGL-IDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQ-VEMKKMESDFEQKLQ 505
            LQ E   L +D  +++ ++ +S+    +++  LD+       L+  E K    +  ++LQ
Sbjct: 346  LQYEFTHLGLDLYLERLRLTESDKLQVQIQAYLDNIFDVGALLEDTETKNAVLEHMEELQ 405

Query: 506  DLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPP 565
                E+ AL +E+ + A  + +  A++++L  ++++  KELE  ++  +  +A   +  P
Sbjct: 406  ----EQVALLTERLRDA--ENESMAKIAELEKQLSQARKELETLRERFSESTAMGASRRP 459

Query: 566  SVPSRAPVPPAPPLPG---------DSGTIIPPPPAPGDSTT----PPPPPPPPPPPPPL 612
              P +AP P AP  P          +   +I     PGD+ +    P     P     P 
Sbjct: 460  PEPEKAP-PAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPT 518

Query: 613  PGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPL 672
            PG    S  P L    A  P P     A  PPPPPLP   G+PSP   P           
Sbjct: 519  PGVPTGSPSPDL--APAAEPAP----GAAPPPPPPLP---GLPSPQEAPPSA-------- 561

Query: 673  PGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPP 732
                  PP  PPLPGS   PPP PPLPG+  +PPPPPP       PPPPP   GP +PPP
Sbjct: 562  ------PPQAPPLPGSPE-PPPAPPLPGD--LPPPPPP-------PPPPPGTDGP-VPPP 604

Query: 733  PPGMGMPPPPPFGFGVPAA-----PVLPFGLTPKKLYKPEVQLRRPNWSKLVAEDLSQDC 787
            PP    PPPPP G G P A       L  G+  KK  + + ++   NW  L    ++   
Sbjct: 605  PP----PPPPPPG-GPPDALGRRDSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTV 659

Query: 788  FWTKVKEDRFENNELFAKLTLT-FSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSK 846
            F T++ +++     +  +L ++ F  Q KT       +    K    +K   +  ++++ 
Sbjct: 660  F-TELNDEK-----VLQELDMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEAN 713

Query: 847  TAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKDE-- 904
             A+NL+I L    +  + I   I   +   L    ++ L++ +P   +  +++  + E  
Sbjct: 714  RAKNLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQR 773

Query: 905  -YDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSES 963
              ++L+E ++F +    +PRL  R+  + F   F +  + + P++ ++ AA   ++ S+ 
Sbjct: 774  PMEELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDK 833

Query: 964  FSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYP 1023
               +LEI L  GNYMN+  R A A+GF +  L  L + KSTD+K TLLH+L ++    YP
Sbjct: 834  LRQILEIVLAFGNYMNSSKRGA-AYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYP 892

Query: 1024 DVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTS 1083
             +  F  +L  ++KA  VS +++  ++  +++ +   +R+         + D  V K   
Sbjct: 893  QLTGFHSDLHFLDKAGSVSLDSVLADVRSLQRGLELTQREF------VRQDDCMVLK--E 944

Query: 1084 FVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKEN 1143
            F++      +KL       +  ++ + EYF  +PK  S   FF       ++F + +K  
Sbjct: 945  FLRANSPTMDKLLADSKTAQEAFESVVEYFGENPKTTSPGLFF-------SLFSRFIKAY 997

Query: 1144 QKRRETEEKMRRAKLAKE---------------------KAEKERLEKQQKREQLIDMNA 1182
            +K  +  E+ ++   A+E                     + + + + + ++R+Q   +  
Sbjct: 998  KKAEQEVEQWKKEAAAQEAGADTPGKGEPPAPKSPPKARRPQMDLISELKRRQQKEPLIY 1057

Query: 1183 EGDETGVMDSLLEALQSGAAFRRKRGPR 1210
            E D  G ++ ++  +++   F  + G R
Sbjct: 1058 ESDRDGAIEDIITVIKT-VPFTARTGKR 1084



 Score =  111 bits (277), Expect = 5e-24
 Identities = 102/431 (23%), Positives = 184/431 (42%), Gaps = 71/431 (16%)

Query: 206 HEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPED 265
           H  I CL+A MN + G   ++     +  +  +++   P       +LL+A+C++    D
Sbjct: 228 HVCIMCLRAIMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHD 287

Query: 266 MNERVLEAMTERAEM-DEVERFQPLLDGLKS-GTTIALKVGCLQLINALITPAEELDFRV 323
           +   +L A     E+  E  RF+ L++  ++  + I   V C+Q IN ++   E ++FRV
Sbjct: 288 I---ILAAFDNFKEVCGEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRV 344

Query: 324 HIRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDD------IRME 377
            ++ E   LGL   L+ LR  E++ ++VQ+  +     ++ +D+   L+D      +   
Sbjct: 345 FLQYEFTHLGLDLYLERLRLTESDKLQVQIQAY----LDNIFDVGALLEDTETKNAVLEH 400

Query: 378 MDDFNEVFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKN 437
           M++  E   +L   ++D++                              E +++I     
Sbjct: 401 MEELQEQVALLTERLRDAE-----------------------------NESMAKI----- 426

Query: 438 GADPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKME 497
            A+ + +    + E+E L ++  + T +  S  +  E EK   +  T    L+++++++E
Sbjct: 427 -AELEKQLSQARKELETLRERFSESTAMGASR-RPPEPEKAPPAAPTRPSALELKVEELE 484

Query: 498 SDFEQKLQDLQGEKDALHSEKQQIA-----------------TEKQDLEAEVSQLTGEVA 540
              +  ++ L+G  DA+  E   +A                 +   DL        G   
Sbjct: 485 E--KGLIRILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAP 542

Query: 541 KLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPP 600
                L        +  +A    PP +P     PPAPPLPGD     PPPP P  +  P 
Sbjct: 543 PPPPPLPGLPSPQEAPPSAPPQAPP-LPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPV 601

Query: 601 PPPPPPPPPPP 611
           PPPPPPPPPPP
Sbjct: 602 PPPPPPPPPPP 612


>gi|157168329 formin 1 [Homo sapiens]
          Length = 1196

 Score =  229 bits (585), Expect = 1e-59
 Identities = 169/577 (29%), Positives = 276/577 (47%), Gaps = 77/577 (13%)

Query: 632  PPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGI 691
            PPPP    A+IPPPPPLP G+G  SP+        PP PP+     +PPPPPP       
Sbjct: 646  PPPP----ASIPPPPPLPSGLGSLSPA--------PPMPPVSAGPPLPPPPPP------- 686

Query: 692  PPPPPPLPGEAGMPPPPPPLPGGPGIP--PPPPFPGGPGIPPPPPGMGMPPPPPFGFGVP 749
             PPP P P  AG PPPPPP    P +P  P PP PGGP   PPPPG+  PPPP   FG+ 
Sbjct: 687  -PPPLPPPSSAGPPPPPPP----PPLPNSPAPPNPGGPPPAPPPPGLAPPPPPGLFFGLG 741

Query: 750  AAPVLPFGLTPKK-LYKPEVQLRRPNWSKLVAEDLSQDC---FWTKVKEDRFENNELFAK 805
            ++        P+K   +P   ++   W+++   D SQ+     W  ++E    +   F  
Sbjct: 742  SSS----SQCPRKPAIEPSCPMKPLYWTRIQISDRSQNATPTLWDSLEEPDIRDPSEFEY 797

Query: 806  LTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEI 865
            L   FS  T   K K   E  E+K  V+    K +K+LD K +Q + I + S  +  ++I
Sbjct: 798  L---FSKDTTQQKKKPLSETYEKKNKVK----KIIKLLDGKRSQTVGILISSLHLEMKDI 850

Query: 866  KNVILEVNEAVLTESMIQNLIKQMPEPEQLKML-----SELKDEYDDLAESEQFGVVMGT 920
            +  I  V+++V+    +  L +   + ++L  +     +  ++E   L + EQF   +  
Sbjct: 851  QQAIFNVDDSVVDLETLAALYENRAQEDELVKIRKYYETSKEEELKLLDKPEQFLHELAQ 910

Query: 921  VPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLLVGNYMNA 980
            +P    R   I+F+  FSE + ++  ++  +T A ++L   +S  ++L + L  GNYMN 
Sbjct: 911  IPNFAERAQCIIFRSVFSEGITSLHRKVEIITRASKDLLHVKSVKDILALILAFGNYMNG 970

Query: 981  GSRNAG-AFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELAHVEK-- 1037
            G+R  G A G+++  L KL+D KS D  + L+ ++ +         L++ D+ A  EK  
Sbjct: 971  GNRTRGQADGYSLEILPKLKDVKSRDNGINLVDYVVKY-------YLRYYDQEAGTEKSV 1023

Query: 1038 -----------ASRVSAENLQKNLDQMKKQISDVERD--VQNFPAATDEKDKFVEKMTSF 1084
                       AS+V  E+L K+L ++K+Q+   E+   V    +  +    F +K+  F
Sbjct: 1024 FPLPEPQDFFLASQVKFEDLIKDLRKLKRQLEASEKQMVVVCKESPKEYLQPFKDKLEEF 1083

Query: 1085 VKDAQEQYNKLRMMHSNMETLYKELGEYFLFDP----KKLSVEEFFMDLHNFRNMFLQAV 1140
             + A++++        N +  ++    YF   P    K+++    FM  + F + F    
Sbjct: 1084 FQKAKKEHKMEESHLENAQKSFETTVRYFGMKPKSGEKEITPSYVFMVWYEFCSDF---- 1139

Query: 1141 KENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQL 1177
            K   KR        R K+A+E   K   EK+ + +++
Sbjct: 1140 KTIWKRESKNISKERLKMAQESVSKLTSEKKVETKKI 1176



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 32/76 (42%), Positives = 33/76 (43%), Gaps = 11/76 (14%)

Query: 564 PPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPP---PPPPPPPPLPGGVCISS 620
           PPS     P PP PPLP       P PP PG     PPPP   PPPPP      G   SS
Sbjct: 692 PPSSAGPPPPPPPPPLPNS-----PAPPNPGGPPPAPPPPGLAPPPPPGLFFGLG---SS 743

Query: 621 PPSLPGGTAISPPPPL 636
               P   AI P  P+
Sbjct: 744 SSQCPRKPAIEPSCPM 759


>gi|52485606 formin-like 2 [Homo sapiens]
          Length = 1092

 Score =  206 bits (525), Expect = 9e-53
 Identities = 152/558 (27%), Positives = 263/558 (47%), Gaps = 38/558 (6%)

Query: 638  GDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIP----- 692
            GD  I   P +  G  +   S +  G ++ P      S  +PPPPPPLP S+  P     
Sbjct: 487  GDGDIAILPVVASGT-LSMGSEVVAGNSVGPTMGAASSGPLPPPPPPLPPSSDTPETVQN 545

Query: 693  -PPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPG--GPGIPPPPPGMGMPPPPPFGFGVP 749
             P  PP+P     PPPPPP P  P  PPPPP PG     +P PP    +P  PP      
Sbjct: 546  GPVTPPMPPP---PPPPPPPPPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPPLPGTSS 602

Query: 750  AAPVLPFGLTPKKLYKP-EVQLRRP--NWSKLVAEDLSQDCFWTKVKEDRFENNELFAKL 806
               V   GL   K+ KP + + R P  NW  L    ++   F      +  ++  +   L
Sbjct: 603  PTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVF------NEIDDERILEDL 656

Query: 807  TL-TFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEI 865
             +  F    KT       +    K+ + +K   ++ +L++  A+NL+I L        EI
Sbjct: 657  NVDEFEEIFKTKAQGPAIDLSSSKQKIPQKGSNKVTLLEANRAKNLAITLRKAGKTADEI 716

Query: 866  KNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKDE---YDDLAESEQFGVVMGTVP 922
               I   +   L    ++ L++ +P   ++K+L   + E    ++L++ ++F +    + 
Sbjct: 717  CKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIE 776

Query: 923  RLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGS 982
            RL  ++  + F   F+E ++ + P++ ++ AA   ++ S+    +LEI L +GNYMN+  
Sbjct: 777  RLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSK 836

Query: 983  RNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVS 1042
            R A  +GF +  L  L DTKSTD+K TLLH+++ + +  Y  V  F +EL +VEKA+ VS
Sbjct: 837  RGA-VYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVS 895

Query: 1043 AENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNM 1102
             EN+  ++ ++++ +   +R+       T  K+        F+ + + +  KL+      
Sbjct: 896  LENVLLDVKELQRGMDLTKREYTMHDHNTLLKE--------FILNNEGKLKKLQDDAKIA 947

Query: 1103 ETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETE----EKMRRAKL 1158
            +  + ++ +YF  +PK      FF     F   + QA +EN+ R++ E    EK+   + 
Sbjct: 948  QDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEA 1007

Query: 1159 AKEKAEKERLEKQQKREQ 1176
              E+ + +    + KR+Q
Sbjct: 1008 LMEQQDPKSPSHKSKRQQ 1025



 Score = 94.4 bits (233), Expect = 6e-19
 Identities = 116/488 (23%), Positives = 191/488 (39%), Gaps = 96/488 (19%)

Query: 206 HEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPED 265
           H  I CL+A MN ++G   ++     +  +  +++   P       +LL+A+C++     
Sbjct: 222 HVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLV---RG 278

Query: 266 MNERVLEAMTERAEM-DEVERFQPLLDGLKS-GTTIALKVGCLQLINALITPAEELDFRV 323
            +E +L A     E+  E +RF+ L++  ++    I   V  +Q IN +           
Sbjct: 279 GHEIILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIV----------- 327

Query: 324 HIRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIR-MEMDDFN 382
                            +  +E+ + RV L     Q E     L   LD ++  E D   
Sbjct: 328 -----------------VHSVEDMNFRVHL-----QYEFTKLGLDEYLDKLKHTESDKLQ 365

Query: 383 EVFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGADPD 442
              Q  L+ V D  A             +  D E +    + +EE    I          
Sbjct: 366 VQIQAYLDNVFDVGA-------------LLEDAETKNAALERVEELEENI---------- 402

Query: 443 FKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQ 502
               HL  +++   ++ +  +K+ + E +  +  K+LD       +   ++  +    ++
Sbjct: 403 ---SHLSEKLQDTENEAM--SKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKE 457

Query: 503 KLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAIT 562
           K + +Q +      EK+    EKQ       +  G++A L   +      M S   A  +
Sbjct: 458 KEEAIQRQSTL---EKKIHELEKQGTIKIQKKGDGDIAILPV-VASGTLSMGSEVVAGNS 513

Query: 563 VPPSV--PSRAPVPPAPP-LPGDS--------GTIIPPPPAPGDSTTPPPPPPPPPPPPP 611
           V P++   S  P+PP PP LP  S        G + PP P P     PPPPPPPPPPPPP
Sbjct: 514 VGPTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPP 573

Query: 612 LPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPP 671
           LPG          P    + P PPL+    +P  PPLP G   P+     G  A+    P
Sbjct: 574 LPG----------PAAETV-PAPPLA--PPLPSAPPLP-GTSSPTVVFNSGLAAVKIKKP 619

Query: 672 LPGSARIP 679
           +    R+P
Sbjct: 620 IKTKFRMP 627


>gi|145309324 FH2 domain containing 1 [Homo sapiens]
          Length = 1143

 Score =  195 bits (495), Expect = 3e-49
 Identities = 142/515 (27%), Positives = 229/515 (44%), Gaps = 45/515 (8%)

Query: 658  SSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLP----GEAGMPPPPPPLPG 713
            S    G     P  + G    P PPPP       PPPPPP P         P  PPP   
Sbjct: 11   SDKENGNIATAPGFMIGQTPPPAPPPP-------PPPPPPSPPCSCSREECPSSPPP--- 60

Query: 714  GPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRP 773
                PPPPP PG P IPPPPPG+   PP     G          L  KK      ++R  
Sbjct: 61   ----PPPPPLPGEPPIPPPPPGL---PPTTHMNGYS-------HLGKKK------RMRSF 100

Query: 774  NWSKLVAEDL-SQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKDQEGGEEKKSV 832
             W  +  E +  +   WT               +   F  Q  T+K+   + G     S 
Sbjct: 101  FWKTIPEEQVRGKTNIWTLAARQEHHYQIDTKTIEELFGQQEDTTKSSLPRRGRTLNSSF 160

Query: 833  QKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEP 892
            ++ + +E+ +LD+K + N+ IFL  F+   + I   I +          ++  +K +PE 
Sbjct: 161  REAR-EEITILDAKRSMNIGIFLKQFKKSPRSIVEDIHQGKSEHYGSETLREFLKFLPES 219

Query: 893  EQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVT 952
            E++K L     +   L+ ++ F   +  VP    R+ A++ K +F     ++  +I  + 
Sbjct: 220  EEVKKLKAFSGDVSKLSLADSFLYGLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLR 279

Query: 953  AACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLH 1012
             A +EL   E   ++L + L  GN MNAG     A GF +S L KL DTK+    M LLH
Sbjct: 280  TAIKELMSCEELHSILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLH 339

Query: 1013 FLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATD 1072
            F+A+  +     +L F ++L HV+K +R+S EN +  L  +  +   ++ ++Q       
Sbjct: 340  FVAQEAQKKDTILLNFSEKLHHVQKTARLSLENTEAELHLLFVRTKSLKENIQ------- 392

Query: 1073 EKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNF 1132
               +  ++M  F++ A E+  +L      ++     L ++F  D K + ++E F    +F
Sbjct: 393  RDGELCQQMEDFLQFAIEKLRELECWKQELQDEAYTLIDFFCEDKKTMKLDECFQIFRDF 452

Query: 1133 RNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKER 1167
               F +AVK+N  R   E  +R+ +  KE+ +K+R
Sbjct: 453  CTKFNKAVKDNHDREAQE--LRQLQRLKEQEQKQR 485



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 35/81 (43%), Positives = 41/81 (50%), Gaps = 7/81 (8%)

Query: 582 DSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDAT 641
           ++G I   P      T PP PPPPPPPPPP P   C  S    P      PPPPL G+  
Sbjct: 14  ENGNIATAPGFMIGQTPPPAPPPPPPPPPPSP--PCSCSREECPSSPPPPPPPPLPGEPP 71

Query: 642 IPPPPPLPEGVGIPSPSSLPG 662
           IPPPPP     G+P  + + G
Sbjct: 72  IPPPPP-----GLPPTTHMNG 87



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 35/85 (41%), Positives = 36/85 (42%), Gaps = 34/85 (40%)

Query: 602 PPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLP 661
           PPP PPPPPP P       PPS        PP   S +     PPP              
Sbjct: 30  PPPAPPPPPPPP-------PPS--------PPCSCSREECPSSPPP-------------- 60

Query: 662 GGTAIPPPPPLPGSARIPPPPPPLP 686
                PPPPPLPG   IPPPPP LP
Sbjct: 61  -----PPPPPLPGEPPIPPPPPGLP 80



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 34/76 (44%), Positives = 38/76 (50%), Gaps = 20/76 (26%)

Query: 562 TVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPP--PPPPPPPPPPPLPGGVCIS 619
           T P  +  + P PPAPP P       PPPP+P  S +    P  PPPPPPPPLPG     
Sbjct: 20  TAPGFMIGQTP-PPAPPPPPP-----PPPPSPPCSCSREECPSSPPPPPPPPLPG----- 68

Query: 620 SPPSLPGGTAISPPPP 635
            PP       I PPPP
Sbjct: 69  EPP-------IPPPPP 77



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 25/66 (37%), Positives = 29/66 (43%), Gaps = 2/66 (3%)

Query: 551 KEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPP--PPP 608
           KE  +++ A   +    P  AP PP PP P            P     PPPPP P  PP 
Sbjct: 13  KENGNIATAPGFMIGQTPPPAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPI 72

Query: 609 PPPLPG 614
           PPP PG
Sbjct: 73  PPPPPG 78



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 25/50 (50%), Positives = 27/50 (54%), Gaps = 13/50 (26%)

Query: 564 PPSVP---SRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPP 610
           PPS P   SR   P +PP P       PPPP PG+   PP PPPPP  PP
Sbjct: 42  PPSPPCSCSREECPSSPPPP-------PPPPLPGE---PPIPPPPPGLPP 81



 Score = 34.3 bits (77), Expect = 0.77
 Identities = 17/31 (54%), Positives = 18/31 (58%), Gaps = 2/31 (6%)

Query: 568 PSRAPVPPAPPLPGDSGTIIPPPPAPGDSTT 598
           PS  P PP PPLPG+    IPPPP     TT
Sbjct: 55  PSSPPPPPPPPLPGEPP--IPPPPPGLPPTT 83


>gi|119120861 formin-like 3 isoform 2 [Homo sapiens]
          Length = 976

 Score =  191 bits (486), Expect = 3e-48
 Identities = 151/535 (28%), Positives = 246/535 (45%), Gaps = 63/535 (11%)

Query: 650  EGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPP 709
            E +    P+ L  G    PP  L   A  PPP   LP    +PPPP P      +PPPPP
Sbjct: 433  EALARVGPAELSEGM---PPSDLDLLAPAPPPEEVLP----LPPPPAP-----PLPPPPP 480

Query: 710  PLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAP--VLPFGLTPKKLYKP- 766
            PLP     PP PP PG                        AAP  VL  GL+  ++ KP 
Sbjct: 481  PLPDK--CPPAPPLPG------------------------AAPSVVLTVGLSAIRIKKPI 514

Query: 767  EVQLRRP--NWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTL-TFSAQTKTSKAKKDQ 823
            + + R P  NW+ L    +S   F         ++ ++   L L  F    KT       
Sbjct: 515  KTKFRLPVFNWTALKPNQISGTVF------SELDDEKILEDLDLDKFEELFKTKAQGPAL 568

Query: 824  EGGEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQ 883
            +    K    +K   ++ +L++  A+NL+I L       +EI   I   +   L    ++
Sbjct: 569  DLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVE 628

Query: 884  NLIKQMPEPEQLKMLSELKDE---YDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQ 940
             L++ +P   ++K+L + + E    ++LA  ++F ++   V RL  R+  + F   F + 
Sbjct: 629  CLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDN 688

Query: 941  VENIKPEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRD 1000
            ++ + P++ ++ AA   ++ S+    +LEI L +GNYMN+  R A  +GF +  L  L D
Sbjct: 689  LQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGA-VYGFKLQSLDLLLD 747

Query: 1001 TKSTDQKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDV 1060
            TKSTD+KMTLLHF+A   +  YPD+  F  EL  VEKA+ VS EN+  ++ ++ + +  +
Sbjct: 748  TKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELI 807

Query: 1061 ERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKL 1120
             R+      +          + +F+   + + +KL+      E  Y  +  YF   PK  
Sbjct: 808  RRECSIHDNSV---------LRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTT 858

Query: 1121 SVEEFFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKRE 1175
                FF     F   + +A +EN+ R++ EE MR  +LA+E  + +     Q+ +
Sbjct: 859  PPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNK 913



 Score =  110 bits (274), Expect = 1e-23
 Identities = 140/571 (24%), Positives = 225/571 (39%), Gaps = 157/571 (27%)

Query: 87  FEQMLLDMNLNEEKQQPLREKDIIIKREMVSQYLYTSKAGMSQKESSKSAMMYIQELRSG 146
           F  +L  MNL  +K + LR+ D   K +++            + +       YIQ+L+S 
Sbjct: 38  FALVLSSMNLPPDKARLLRQYDNEKKWDLICD--------QERFQVKNPPHTYIQKLQSF 89

Query: 147 L-----------RDMPLLSCLESLRVSLNNNPVSWVQTF---GAEGLASLLDILK----- 187
           L           R       L  L +SL  N + WV+ F     +GL  L+D L      
Sbjct: 90  LDPSVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCS 149

Query: 188 ---------------RLHDEKEETAGSYDSRNKHEIIRCLKAFMNNKFGIKTMLETEEGI 232
                          RL  +K++          H  I CL+A MN ++G   ++     +
Sbjct: 150 VMYSTLPGRRALKNSRLVSQKDDV---------HVCILCLRAIMNYQYGFNLVMSHPHAV 200

Query: 233 LLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEM-DEVERFQPLLD 291
             +  +++   P       +LL+A+C++      +E +L A     E+  E+ RF+ L++
Sbjct: 201 NEIALSLNNKNPRTKALVLELLAAVCLV---RGGHEIILAAFDNFKEVCKELHRFEKLME 257

Query: 292 GLKS-GTTIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQDLREIENEDMR 350
             ++  + I   V C+Q IN ++   E+++FRVH++ E  +LGL + LQ  R  E+E ++
Sbjct: 258 YFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQ 317

Query: 351 VQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSILQHLLL 410
           VQ+  +     ++ +D+ G L+D         E   + L  V++   E H   + + LL 
Sbjct: 318 VQIQAY----LDNVFDVGGLLEDA--------ETKNVALEKVEE--LEEHVSHLTEKLLD 363

Query: 411 VRNDYEARPQYYKLIEECISQIVLHKNGADPDFKCRHLQIEIEGLIDQMIDKTKVEKSEA 470
           + N+   R                                                    
Sbjct: 364 LENENMMR---------------------------------------------------- 371

Query: 471 KAAELEKKLDSELTARHELQVEMKKMESDFEQ--KLQDLQGEKDALHSEKQQIATEKQDL 528
             AELEK+L   L    EL+   +  E+   Q   L+ L  EK+     +  +    + L
Sbjct: 372 -VAELEKQL---LQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGL 427

Query: 529 EAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPS-VPSRAPVPPAPP-LPGDSGTI 586
           E+  S+    V              A LS     +PPS +   AP PP    LP      
Sbjct: 428 ESVDSEALARVGP------------AELSEG---MPPSDLDLLAPAPPPEEVLP------ 466

Query: 587 IPPPPAPGDSTTPPPPPPPP---PPPPPLPG 614
           +PPPPAP     PPPPPP P   PP PPLPG
Sbjct: 467 LPPPPAP---PLPPPPPPLPDKCPPAPPLPG 494


>gi|119120874 formin-like 3 isoform 1 [Homo sapiens]
          Length = 1027

 Score =  191 bits (486), Expect = 3e-48
 Identities = 151/535 (28%), Positives = 246/535 (45%), Gaps = 63/535 (11%)

Query: 650  EGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPP 709
            E +    P+ L  G    PP  L   A  PPP   LP    +PPPP P      +PPPPP
Sbjct: 484  EALARVGPAELSEGM---PPSDLDLLAPAPPPEEVLP----LPPPPAP-----PLPPPPP 531

Query: 710  PLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAP--VLPFGLTPKKLYKP- 766
            PLP     PP PP PG                        AAP  VL  GL+  ++ KP 
Sbjct: 532  PLPDK--CPPAPPLPG------------------------AAPSVVLTVGLSAIRIKKPI 565

Query: 767  EVQLRRP--NWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTL-TFSAQTKTSKAKKDQ 823
            + + R P  NW+ L    +S   F         ++ ++   L L  F    KT       
Sbjct: 566  KTKFRLPVFNWTALKPNQISGTVF------SELDDEKILEDLDLDKFEELFKTKAQGPAL 619

Query: 824  EGGEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQ 883
            +    K    +K   ++ +L++  A+NL+I L       +EI   I   +   L    ++
Sbjct: 620  DLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVE 679

Query: 884  NLIKQMPEPEQLKMLSELKDE---YDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQ 940
             L++ +P   ++K+L + + E    ++LA  ++F ++   V RL  R+  + F   F + 
Sbjct: 680  CLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDN 739

Query: 941  VENIKPEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRD 1000
            ++ + P++ ++ AA   ++ S+    +LEI L +GNYMN+  R A  +GF +  L  L D
Sbjct: 740  LQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGA-VYGFKLQSLDLLLD 798

Query: 1001 TKSTDQKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDV 1060
            TKSTD+KMTLLHF+A   +  YPD+  F  EL  VEKA+ VS EN+  ++ ++ + +  +
Sbjct: 799  TKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELI 858

Query: 1061 ERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKL 1120
             R+      +          + +F+   + + +KL+      E  Y  +  YF   PK  
Sbjct: 859  RRECSIHDNSV---------LRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTT 909

Query: 1121 SVEEFFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKRE 1175
                FF     F   + +A +EN+ R++ EE MR  +LA+E  + +     Q+ +
Sbjct: 910  PPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNK 964



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 107/418 (25%), Positives = 173/418 (41%), Gaps = 106/418 (25%)

Query: 206 HEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPED 265
           H  I CL+A MN ++G   ++     +  +  +++   P       +LL+A+C++     
Sbjct: 225 HVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLV---RG 281

Query: 266 MNERVLEAMTERAEM-DEVERFQPLLDGLKS-GTTIALKVGCLQLINALITPAEELDFRV 323
            +E +L A     E+  E+ RF+ L++  ++  + I   V C+Q IN ++   E+++FRV
Sbjct: 282 GHEIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRV 341

Query: 324 HIRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNE 383
           H++ E  +LGL + LQ  R  E+E ++VQ+  +     ++ +D+ G L+D         E
Sbjct: 342 HLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAY----LDNVFDVGGLLEDA--------E 389

Query: 384 VFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDF 443
              + L  V++   E H   + + LL + N+   R                         
Sbjct: 390 TKNVALEKVEE--LEEHVSHLTEKLLDLENENMMR------------------------- 422

Query: 444 KCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQ- 502
                                        AELEK+L   L    EL+   +  E+   Q 
Sbjct: 423 ----------------------------VAELEKQL---LQREKELESIKETYENTSHQV 451

Query: 503 -KLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAI 561
             L+ L  EK+     +  +    + LE+  S+    V              A LS    
Sbjct: 452 HTLRRLIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGP------------AELSEG-- 497

Query: 562 TVPPS-VPSRAPVPPAPP-LPGDSGTIIPPPPAPGDSTTPPPPPPPP---PPPPPLPG 614
            +PPS +   AP PP    LP      +PPPPAP     PPPPPP P   PP PPLPG
Sbjct: 498 -MPPSDLDLLAPAPPPEEVLP------LPPPPAP---PLPPPPPPLPDKCPPAPPLPG 545


>gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2)
            interacting protein [Homo sapiens]
          Length = 1211

 Score =  172 bits (435), Expect = 2e-42
 Identities = 136/472 (28%), Positives = 220/472 (46%), Gaps = 47/472 (9%)

Query: 694  PPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPG---------------IPPPPPGMGM 738
            PPPPL      PPPPPPLP     P      G  G               +PPPPP   +
Sbjct: 750  PPPPLS-----PPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPP-L 803

Query: 739  PPPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKLVAEDLSQDCFWTKVKED--- 795
            PPP P      A P+L  GL  ++     + ++R  W ++   + S+   W ++ ED   
Sbjct: 804  PPPVPC-----APPMLSRGLGHRRSETSHMSVKRLRWEQV---ENSEGTIWGQLGEDSDY 855

Query: 796  -RFENNELFAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSIF 854
             +  +   +  L L F  Q    K  K   G E     +KK+V E  +L  K A N SI 
Sbjct: 856  DKLSDMVKYLDLELHFGTQ----KPAKPVPGPEP---FRKKEVVE--ILSHKKAYNTSIL 906

Query: 855  LGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKDEYDDLAESEQF 914
            L   ++   E++ V++ +    L  + +  L+   P+ ++ +     ++    L+E +QF
Sbjct: 907  LAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQF 966

Query: 915  GVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLLV 974
             + M +VP  + RL ++ F+    E+ E I+  +  +  A  EL+ S   + +LE  L +
Sbjct: 967  VLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAM 1026

Query: 975  GNYMNAGS-RNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELA 1033
            GNY+N G  +     GF I+FL +L  TK+ D K T LH LA+     +P++L F  +L 
Sbjct: 1027 GNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLP 1086

Query: 1034 HVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYN 1093
             V  A++V+   L  +L  +   IS+++   Q+   +++  DKF   M+SF++ AQ    
Sbjct: 1087 TVPLAAKVNQRALTSDLADLHGTISEIQDACQSISPSSE--DKFAMVMSSFLETAQPALR 1144

Query: 1094 KL-RMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQ 1144
             L  +    ME L K L  +F  D K  + E FF     F + F +A+ + Q
Sbjct: 1145 ALDGLQREAMEELGKALA-FFGEDSKATTSEAFFGIFAEFMSKFERALSDLQ 1195



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 27/63 (42%), Positives = 27/63 (42%), Gaps = 5/63 (7%)

Query: 600 PPPPPPPPPPPPLPGGVCISSPPSLPGGTA-----ISPPPPLSGDATIPPPPPLPEGVGI 654
           PPPP  PPPPPPLP      S  S  G          P   LS     PPPPPLP  V  
Sbjct: 750 PPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLPPPVPC 809

Query: 655 PSP 657
             P
Sbjct: 810 APP 812



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 32/90 (35%), Positives = 42/90 (46%), Gaps = 16/90 (17%)

Query: 549 AKKEMASLSAAAIT--VPPSVPSRAPVPPAP-----PLPGDSGTIIPPPPAPGDSTT--- 598
           + +E +SL+ ++I+  +PP   S  P PP P     P    S     P  A     T   
Sbjct: 733 SSEEGSSLTYSSISDHIPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLS 792

Query: 599 -PPPPPPPPPPPPPLPGGVCISSPPSLPGG 627
            P PPPPPPP PPP+P      +PP L  G
Sbjct: 793 HPVPPPPPPPLPPPVP-----CAPPMLSRG 817



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 48/167 (28%), Positives = 58/167 (34%), Gaps = 49/167 (29%)

Query: 568 PSRAPVPPAPPLPGD----SGTIIPPPPAP-------------------GDSTTPPPPPP 604
           PS  P  P P +PG+     GT +P  P P                   G   T      
Sbjct: 520 PSECPEMPLPLIPGERQAGDGTSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRA 579

Query: 605 PPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPP--PPLPEGVGIPSPSSLPG 662
            PP P P       + P +L G   +S P     +  +P P   PL  G G+ SPSS   
Sbjct: 580 SPPGPSP----AVTTGPRTLSG---VSWP----SERLLPSPCYHPLCSG-GLASPSS--- 624

Query: 663 GTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPP 709
            +   P   L  S      P P PG   I P  PP P     P  PP
Sbjct: 625 -SESHPYASLDSSRA----PSPQPGPGPICPDSPPSPD----PTRPP 662


>gi|58331242 formin homology 2 domain containing 3 [Homo sapiens]
          Length = 1439

 Score =  144 bits (363), Expect = 5e-34
 Identities = 123/474 (25%), Positives = 219/474 (46%), Gaps = 52/474 (10%)

Query: 701  EAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPP-PG-MGMPPPPPFGFGVPAAPVLPFGL 758
            EA  PPPPPP P   G+PPPPP P    IPPPP PG + +PPPP F              
Sbjct: 842  EAPGPPPPPP-PTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPVFN------------- 887

Query: 759  TPKKLYKPEVQLRRPNWSKLVAEDLSQDCFWTKV-------KEDRFENNELFAKLTLTFS 811
             P+ L   +V   +P ++K   +  +   FW +V       K +R     L++KL     
Sbjct: 888  APQGLGWSQVPRGQPTFTK---KKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLE---P 941

Query: 812  AQTKTSKAKKDQEGGEEKKSVQKK-----KVKELKVLDSKTAQNLSIFLGSFRMPYQEIK 866
             +  TS+ +   E   ++ SV KK     K +E+ VLDSK +  ++I L +   P + IK
Sbjct: 942  IKVDTSRLEHLFESKSKELSVSKKTAADGKRQEIIVLDSKRSNAINIGL-TVLPPPRTIK 1000

Query: 867  NVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSE--LKDEYDDLAESEQFGVVMGTVPRL 924
              IL  +E  L +  I+ ++  +P  E+ + + E  L +    L  +EQF + + ++  L
Sbjct: 1001 IAILNFDEYALNKEGIEKILTMIPTDEEKQKIQEAQLANPEIPLGSAEQFLLTLSSISEL 1060

Query: 925  RPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRN 984
              RL+   FK+ +    + +   ++ +    ++L  +++   +L   L +GN++N  +  
Sbjct: 1061 SARLHLWAFKMDYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAK 1120

Query: 985  AGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAE 1044
            A    F +S+L K+ + K T  K +LLH +  +   ++PD      E+  + ++++V  +
Sbjct: 1121 A----FELSYLEKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFD 1176

Query: 1045 NLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMET 1104
             LQ NL QM+++      D     A  + K    ++M+ F+KD  E+   L+++H  +  
Sbjct: 1177 QLQDNLCQMERRCK-ASWDHLKAIAKHEMKPVLKQRMSEFLKDCAERIIILKIVHRRIIN 1235

Query: 1105 LYKELGEYFLFDPKKLS----------VEEFFMDLHNFRNMFLQAVKENQKRRE 1148
             +     +    P  +           + EF ++    R   LQ  ++    RE
Sbjct: 1236 RFHSFLLFMGHPPYAIREVNINKFCRIISEFALEYRTTRERVLQQKQKRANHRE 1289



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 29/69 (42%), Positives = 35/69 (50%), Gaps = 25/69 (36%)

Query: 592 APGDSTTPPPPPP-----PPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPP 646
           APG    PPPPPP     PPPPPPPL   +               PPPP+ G+  +PPPP
Sbjct: 843 APGP---PPPPPPTFLGLPPPPPPPLLDSI---------------PPPPVPGNLLVPPPP 884

Query: 647 PL--PEGVG 653
               P+G+G
Sbjct: 885 VFNAPQGLG 893



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 27/66 (40%), Positives = 32/66 (48%), Gaps = 12/66 (18%)

Query: 571 APVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPP--SLPGGT 628
           AP PP PP P   G  +PPP        PPPP     PPPP+PG + +  PP  + P G 
Sbjct: 843 APGPPPPPPPTFLG--LPPP--------PPPPLLDSIPPPPVPGNLLVPPPPVFNAPQGL 892

Query: 629 AISPPP 634
             S  P
Sbjct: 893 GWSQVP 898



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 26/81 (32%), Positives = 30/81 (37%), Gaps = 40/81 (49%)

Query: 602 PPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLP 661
           P PPPPPPP   G                           +PPPPP P    I       
Sbjct: 844 PGPPPPPPPTFLG---------------------------LPPPPPPPLLDSI------- 869

Query: 662 GGTAIPPPPPLPGSARIPPPP 682
                 PPPP+PG+  +PPPP
Sbjct: 870 ------PPPPVPGNLLVPPPP 884



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 21/40 (52%), Positives = 24/40 (60%), Gaps = 4/40 (10%)

Query: 564 PPSVPSRAPVPPAPPLPG-DSGTIIPPPPAPGDSTTPPPP 602
           PP  P+   +PP PP P  DS   IPPPP PG+   PPPP
Sbjct: 848 PPPPPTFLGLPPPPPPPLLDS---IPPPPVPGNLLVPPPP 884


>gi|118572599 formin homology 2 domain containing 1 [Homo sapiens]
          Length = 1164

 Score =  133 bits (335), Expect = 9e-31
 Identities = 123/499 (24%), Positives = 217/499 (43%), Gaps = 61/499 (12%)

Query: 678  IPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPPGMG 737
            IP P PPLP  +G+PPPPP         PPPPP+ G        PFP     PPPP    
Sbjct: 569  IPAPSPPLPLLSGVPPPPP--------LPPPPPIKG--------PFP-----PPPP---- 603

Query: 738  MPPPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKLVAEDLSQDC--FWTKVKED 795
            +P   P    VP +  LP      KL+  E++L   +    V+      C   W  +   
Sbjct: 604  LPLAAPLPHSVPDSSALPTKRKTVKLFWRELKLAGGHG---VSASRFGPCATLWASLDPV 660

Query: 796  RFENNELFAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSIFL 855
              +     A+L   F ++ K  +    ++ GE ++++         VLD K +  ++I L
Sbjct: 661  SVDT----ARLEHLFESRAK--EVLPSKKAGEGRRTM-------TTVLDPKRSNAINIGL 707

Query: 856  GSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKDEYDD--LAESEQ 913
             +   P   IK  +L  +E  +++  I+ L+  MP  E+ + + E +    D  L  +E 
Sbjct: 708  TTL-PPVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIEEAQLANPDIPLGPAEN 766

Query: 914  FGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLL 973
            F + + ++  L  RL    FKL +      I   +  +    E+L ++ +F  +L   L 
Sbjct: 767  FLMTLASIGGLAARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLA 826

Query: 974  VGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELA 1033
            VGN++N GS+++   GF +S+L K+ + K T ++ +LLH L  L     P+      E+ 
Sbjct: 827  VGNFLN-GSQSS---GFELSYLEKVSEVKDTVRRQSLLHHLCSLVLQTRPESSDLYSEIP 882

Query: 1034 HVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYN 1093
             + + ++V  E L +NL Q++++    E  +++  A  +       ++T F+     +  
Sbjct: 883  ALTRCAKVDFEQLTENLGQLERRSRAAEESLRSL-AKHELAPALRARLTHFLDQCARRVA 941

Query: 1094 KLRMMHSNMETLYKELGEYFLFDPKKL----------SVEEFFMDLHNFRNMFLQAVKEN 1143
             LR++H  +   +     Y  + P+            ++ EF ++    R   LQ  ++ 
Sbjct: 942  MLRIVHRRVCNRFHAFLLYLGYTPQAAREVRIMQFCHTLREFALEYRTCRERVLQQQQKQ 1001

Query: 1144 QKRRETEEKMRRAKLAKEK 1162
               RE  +   R     EK
Sbjct: 1002 ATYRERNKTRGRMITETEK 1020



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 30/64 (46%), Positives = 35/64 (54%), Gaps = 12/64 (18%)

Query: 604 PPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGG 663
           P P PP PL  GV    PP LP      PPPP+ G    PPPPPLP  +  P P S+P  
Sbjct: 570 PAPSPPLPLLSGV--PPPPPLP------PPPPIKGP--FPPPPPLP--LAAPLPHSVPDS 617

Query: 664 TAIP 667
           +A+P
Sbjct: 618 SALP 621



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 33/86 (38%), Positives = 46/86 (53%), Gaps = 18/86 (20%)

Query: 547 EDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPP-- 604
           ED  ++M  L+  ++     +P+     P+PPLP  SG  +PPPP       PPPPP   
Sbjct: 551 EDEDQDM--LNVESVEAGKDIPA-----PSPPLPLLSG--VPPPPP-----LPPPPPIKG 596

Query: 605 PPPPPPPLPGGVCISSPPSLPGGTAI 630
           P PPPPPLP  +    P S+P  +A+
Sbjct: 597 PFPPPPPLP--LAAPLPHSVPDSSAL 620



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 25/64 (39%), Positives = 33/64 (51%), Gaps = 15/64 (23%)

Query: 631 SPPPPLSGDATIPPPPPL--PEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGS 688
           +P PPL   + +PPPPPL  P  +  P           PPPPPLP +A   P P  +P S
Sbjct: 571 APSPPLPLLSGVPPPPPLPPPPPIKGP----------FPPPPPLPLAA---PLPHSVPDS 617

Query: 689 AGIP 692
           + +P
Sbjct: 618 SALP 621


>gi|11386183 WAS protein family, member 2 [Homo sapiens]
          Length = 498

 Score =  118 bits (296), Expect = 3e-26
 Identities = 79/204 (38%), Positives = 93/204 (45%), Gaps = 41/204 (20%)

Query: 560 AITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPA----PGDS--------------TTPPP 601
           A + PP   S +   P+P    D+   +PPPPA    P D+               +P  
Sbjct: 243 ASSYPPPPQSDSASSPSPSFSEDN---LPPPPAEFSYPVDNQRGSGLAGPKRSSVVSPSH 299

Query: 602 PPPPPP---PPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPS 658
           PPP PP   PP P PG    + PP+ P      PPPP+ G   IPPPPP P G G P   
Sbjct: 300 PPPAPPLGSPPGPKPG---FAPPPAPP-----PPPPPMIG---IPPPPP-PVGFGSPGTP 347

Query: 659 SLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIP 718
             P   + PP P    +A  PPPPPP      +PPPP   P     PPPPPP P G   P
Sbjct: 348 PPPSPPSFPPHPDF--AAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPPPG---P 402

Query: 719 PPPPFPGGPGIPPPPPGMGMPPPP 742
           PPPPF G  G P  PP +     P
Sbjct: 403 PPPPFTGADGQPAIPPPLSDTTKP 426



 Score =  116 bits (290), Expect = 2e-25
 Identities = 79/184 (42%), Positives = 86/184 (46%), Gaps = 30/184 (16%)

Query: 589 PPPAPGDSTTPPPPPPP----PPPPPPLPGGVCISSPPSLPG---GTAISPPPPLSGDAT 641
           PPP   DS + P P       PPPP      V       L G    + +SP  P      
Sbjct: 247 PPPPQSDSASSPSPSFSEDNLPPPPAEFSYPVDNQRGSGLAGPKRSSVVSPSHP------ 300

Query: 642 IPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLP-GSAGIPPPP----- 695
            PP PPL    G P P   P     PPPPP+ G   IPPPPPP+  GS G PPPP     
Sbjct: 301 -PPAPPLGSPPG-PKPGFAPPPAPPPPPPPMIG---IPPPPPPVGFGSPGTPPPPSPPSF 355

Query: 696 PPLPGEAGMPPPPPPLPGG-PGIPPPP---PFPGGPGIPPPPPGMGMPPPPPFGFGVPAA 751
           PP P  A  PPPPPP     P +PPPP   P  G P  PPPPP  G PPPPPF  G    
Sbjct: 356 PPHPDFAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPPPG-PPPPPF-TGADGQ 413

Query: 752 PVLP 755
           P +P
Sbjct: 414 PAIP 417



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 37/88 (42%), Positives = 38/88 (43%), Gaps = 24/88 (27%)

Query: 564 PPSVPSRAPVP--PAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSP 621
           PP  P  A  P  P PPL   +G   PP         PPPPPPP PPPPP  G       
Sbjct: 366 PPPPPPAADYPTLPPPPLSQPTGGAPPP---------PPPPPPPGPPPPPFTGA------ 410

Query: 622 PSLPGGTAISPPPPLSGDATIPPPPPLP 649
               G  AI  PPPLS   T  P   LP
Sbjct: 411 ---DGQPAI--PPPLSD--TTKPKSSLP 431


>gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo
           sapiens]
          Length = 505

 Score =  118 bits (295), Expect = 4e-26
 Identities = 69/155 (44%), Positives = 75/155 (48%), Gaps = 46/155 (29%)

Query: 588 PPPPAPGDSTTPPPPPPP----PPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIP 643
           PPPP P     PPPPPPP    PPPPP                G    PPPP       P
Sbjct: 277 PPPPPPSRGGPPPPPPPPHNSGPPPPP--------------ARGRGAPPPPPSRAPTAAP 322

Query: 644 PPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSA--GIPPPPPPLPGE 701
           PPPP       PS  S+    A+PPPPP   +   PPPPP LP SA  G PPPPP + G 
Sbjct: 323 PPPP-------PSRPSV----AVPPPPP---NRMYPPPPPALPSSAPSGPPPPPPSVLGV 368

Query: 702 AGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPPGM 736
             + PPPP        PPPPP PG    PPPPPG+
Sbjct: 369 GPVAPPPP--------PPPPPPPG----PPPPPGL 391



 Score =  109 bits (273), Expect = 1e-23
 Identities = 60/129 (46%), Positives = 63/129 (48%), Gaps = 16/129 (12%)

Query: 631 SPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAG 690
           +PPPP       PPPPP P   G P P +   G   PPPPP       PPPPPP   S  
Sbjct: 276 APPPPPPSRGGPPPPPPPPHNSGPPPPPAR--GRGAPPPPPSRAPTAAPPPPPPSRPSVA 333

Query: 691 IPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPG----GPGIPPPPPGMGMPPPPPFGF 746
           +PPPPP        PPPPP LP      PPPP P     GP  PPPPP    PPPPP   
Sbjct: 334 VPPPPP----NRMYPPPPPALPSSAPSGPPPPPPSVLGVGPVAPPPPPP---PPPPP--- 383

Query: 747 GVPAAPVLP 755
           G P  P LP
Sbjct: 384 GPPPPPGLP 392



 Score =  105 bits (261), Expect = 4e-22
 Identities = 73/195 (37%), Positives = 87/195 (44%), Gaps = 49/195 (25%)

Query: 523 TEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGD 582
           +E Q  + E S++  +  + T  +E  K E+                R   PP PP P  
Sbjct: 242 SEAQLKDRETSKVIYDFIEKTGGVEAVKNEL----------------RRQAPPPPP-PSR 284

Query: 583 SGTIIPPPPAPGDSTTPPPPP-----PPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLS 637
            G   PPPP P  ++ PPPPP      PPPPP   P       PPS P   A+ PPPP  
Sbjct: 285 GGP--PPPPPPPHNSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRP-SVAVPPPPP-- 339

Query: 638 GDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPP 697
            +   PPPPP         PSS P G   PPPP + G   + PPPPP       PPPPPP
Sbjct: 340 -NRMYPPPPP-------ALPSSAPSGPP-PPPPSVLGVGPVAPPPPP-------PPPPPP 383

Query: 698 LPGEAGMPPPPPPLP 712
                  PPPPP LP
Sbjct: 384 ------GPPPPPGLP 392



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 31/68 (45%), Positives = 34/68 (50%), Gaps = 3/68 (4%)

Query: 688 SAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFG 747
           + G+      L  +A   PPPPP  GGP  PPPPP   GP  PPP  G G PPPPP    
Sbjct: 262 TGGVEAVKNELRRQAP--PPPPPSRGGPPPPPPPPHNSGPP-PPPARGRGAPPPPPSRAP 318

Query: 748 VPAAPVLP 755
             A P  P
Sbjct: 319 TAAPPPPP 326



 Score = 37.4 bits (85), Expect = 0.091
 Identities = 20/43 (46%), Positives = 20/43 (46%), Gaps = 9/43 (20%)

Query: 718 PPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTP 760
           PPPPP  GGP     PP    PPPPP   G P  P    G  P
Sbjct: 278 PPPPPSRGGP-----PP----PPPPPHNSGPPPPPARGRGAPP 311


>gi|117306167 proline-rich protein BstNI subfamily 3 precursor [Homo
           sapiens]
          Length = 309

 Score =  117 bits (293), Expect = 7e-26
 Identities = 90/249 (36%), Positives = 94/249 (37%), Gaps = 74/249 (29%)

Query: 568 PSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLP-- 625
           P R P PP  P     G     PP  G+ +  PPP P  P  PP  GG     PP  P  
Sbjct: 47  PQRTPPPPGKP----EGR----PPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGK 98

Query: 626 -------GGTAISPPPPLSGDATIPP---------PPPLPEGVGIPSPSSLPGGTAIPPP 669
                  GG     PPP  G    PP         PPP P   G P      GG     P
Sbjct: 99  PEGQPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRP---GKPEGPPPQGGNQSQGP 155

Query: 670 PPLPGSARIPPP--------PPPLPGSAGIPPP--------PPPLPGEAGMPPP------ 707
           PP PG    PPP        PPP PG    PPP        PPP PG+   PPP      
Sbjct: 156 PPRPGKPEGPPPQGGNQSQGPPPHPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQS 215

Query: 708 --PPPLPGGPGIPP---------PPPFPGGPGIP----------PPPPGMGMPPPPPFGF 746
             PPP PG P  PP         PPP PG P  P          PPPPG    PPPP   
Sbjct: 216 QGPPPRPGKPEGPPSQGGNKPQGPPPHPGKPQGPPPQEGNKPQRPPPPGRPQGPPPP--G 273

Query: 747 GVPAAPVLP 755
           G P  P+ P
Sbjct: 274 GNPQQPLPP 282



 Score =  116 bits (290), Expect = 2e-25
 Identities = 87/230 (37%), Positives = 93/230 (40%), Gaps = 50/230 (21%)

Query: 568 PSRAPVPPAPPLPGDSGTIIPPP---------PAPGDSTTPPPPPPPPPPPPPLPGGVCI 618
           P R   P  PP  G + +  PPP         P  G+ +  PPP P  P  PP  GG   
Sbjct: 72  PPRPGKPEGPPPQGGNQSQGPPPRPGKPEGQPPQGGNQSQGPPPRPGKPEGPPPQGGNQS 131

Query: 619 SSPPSLPGGTAISPPPPLSGDATIPPPPP-LPEGVGIPSPSSLPGGTAIPPPPPLPGSAR 677
             PP  PG     PPP     +  PPP P  PEG   P P    GG     PPP PG   
Sbjct: 132 QGPPPRPGKPE-GPPPQGGNQSQGPPPRPGKPEG---PPPQ---GGNQSQGPPPHPGKPE 184

Query: 678 IPPP--------PPPLPGSAGIPPP--------PPPLPGEAGMPPP--------PPPLPG 713
            PPP        PPP PG    PPP        PPP PG+   PP         PPP PG
Sbjct: 185 GPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPSQGGNKPQGPPPHPG 244

Query: 714 GPGIPPP--------PPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLP 755
            P  PPP        PP PG P  PPPP G    P PP   G P  P  P
Sbjct: 245 KPQGPPPQEGNKPQRPPPPGRPQGPPPPGGNPQQPLPP-PAGKPQGPPPP 293



 Score =  111 bits (278), Expect = 4e-24
 Identities = 80/204 (39%), Positives = 84/204 (41%), Gaps = 33/204 (16%)

Query: 564 PPSVPSRAPVPPA---------PPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPG 614
           PP  P +   PP          PP PG       PPP  G+ +  PPP P  P  PP  G
Sbjct: 113 PPPRPGKPEGPPPQGGNQSQGPPPRPGKPEG---PPPQGGNQSQGPPPRPGKPEGPPPQG 169

Query: 615 GVCISSPPSLPGGTAISPPPPLSGDATIPPP-PPLPEGVGIPSPSSLPGGTAIPPPPPLP 673
           G     PP  PG     PPP     +  PPP P  PEG   P P    GG     PPP P
Sbjct: 170 GNQSQGPPPHPGKPE-GPPPQGGNQSQGPPPRPGKPEG---PPPQ---GGNQSQGPPPRP 222

Query: 674 GSARIPPP--------PPPLPGSAGIPPP----PPPLPGEAGMPPPPPPLPGGPGIPPPP 721
           G    PP         PPP PG    PPP     P  P   G P  PPP  G P  P PP
Sbjct: 223 GKPEGPPSQGGNKPQGPPPHPGKPQGPPPQEGNKPQRPPPPGRPQGPPPPGGNPQQPLPP 282

Query: 722 PFPGGPGIPPPPPGMGMPPPPPFG 745
           P  G P  PPPPP  G P  PP G
Sbjct: 283 P-AGKPQGPPPPPQGGRPHRPPQG 305



 Score =  105 bits (262), Expect = 3e-22
 Identities = 80/224 (35%), Positives = 86/224 (38%), Gaps = 53/224 (23%)

Query: 591 PAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPE 650
           P  G+     PPPP  P   P  GG     PP  PG     PPP     +  PPP P   
Sbjct: 41  PQGGNQPQRTPPPPGKPEGRPPQGGNQSQGPPPRPGKPE-GPPPQGGNQSQGPPPRP--- 96

Query: 651 GVGIPSPSSLPGGTAIPPPPPLPGSARIPPP--------PPPLPGSAGIPPP-------- 694
             G P      GG     PPP PG    PPP        PPP PG    PPP        
Sbjct: 97  --GKPEGQPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQG 154

Query: 695 PPPLPGEAGMPPP--------PPPLPGGPGIPP---------PPPFPGGPGIPP------ 731
           PPP PG+   PPP        PPP PG P  PP         PPP PG P  PP      
Sbjct: 155 PPPRPGKPEGPPPQGGNQSQGPPPHPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQ 214

Query: 732 ---PPPGMGMPPPPPF-----GFGVPAAPVLPFGLTPKKLYKPE 767
              PPP  G P  PP        G P  P  P G  P++  KP+
Sbjct: 215 SQGPPPRPGKPEGPPSQGGNKPQGPPPHPGKPQGPPPQEGNKPQ 258



 Score = 31.6 bits (70), Expect = 5.0
 Identities = 19/47 (40%), Positives = 20/47 (42%), Gaps = 4/47 (8%)

Query: 564 PPSVPSRAPVP---PAPPLPGDSGTII-PPPPAPGDSTTPPPPPPPP 606
           PP  P   P P   P  PLP  +G    PPPP  G     PP   PP
Sbjct: 262 PPGRPQGPPPPGGNPQQPLPPPAGKPQGPPPPPQGGRPHRPPQGQPP 308


>gi|148536848 carboxyl ester lipase precursor [Homo sapiens]
          Length = 756

 Score =  116 bits (290), Expect = 2e-25
 Identities = 84/199 (42%), Positives = 96/199 (48%), Gaps = 20/199 (10%)

Query: 560 AITVPPSVPSRA-PVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCI 618
           A  VPP+  S A PVPP     GDS T   P P  GDS  PP PP      PP+P     
Sbjct: 560 ATPVPPTGDSEATPVPPT----GDSETA--PVPPTGDSGAPPVPPTGDSGAPPVPPTGDS 613

Query: 619 SSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARI 678
            +PP  P G + +PP P +GD+  PP PP  +    P P   P G +  PP P  G +  
Sbjct: 614 GAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVP---PTGDSGAPPVPPTGDSGA 670

Query: 679 PPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPP--GM 736
           PP PP   G AG PP PP   G++G PP PP   G  G PP  P  G     P PP    
Sbjct: 671 PPVPPT--GDAGPPPVPPT--GDSGAPPVPPT--GDSGAPPVTP-TGDSETAPVPPTGDS 723

Query: 737 GMPPPPPFGFGVPAAPVLP 755
           G PP PP G    AAPV P
Sbjct: 724 GAPPVPPTG-DSEAAPVPP 741



 Score =  100 bits (249), Expect = 9e-21
 Identities = 68/171 (39%), Positives = 79/171 (46%), Gaps = 24/171 (14%)

Query: 589 PPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPL 648
           P P  GDS   P PP       P+P           P G + +PP P +GD+  PP PP 
Sbjct: 562 PVPPTGDSEATPVPPTGDSETAPVP-----------PTGDSGAPPVPPTGDSGAPPVPPT 610

Query: 649 PEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPP 708
            +    P P   P G +  PP P  G +  PP PP   G +G PP PP   G++G PP P
Sbjct: 611 GDSGAPPVP---PTGDSGAPPVPPTGDSGAPPVPP--TGDSGAPPVPP--TGDSGAPPVP 663

Query: 709 PPLPGGPGIPPPPPFPGGPGIPPPPP--GMGMPPPPPFGFGVPAAPVLPFG 757
           P   G  G PP PP  G  G PP PP    G PP PP G    A PV P G
Sbjct: 664 P--TGDSGAPPVPP-TGDAGPPPVPPTGDSGAPPVPPTG-DSGAPPVTPTG 710



 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 65/165 (39%), Positives = 76/165 (46%), Gaps = 21/165 (12%)

Query: 558 AAAITVPPSVPSRAP-VPP-----APPLP--GDSGTIIPPPPAPGDSTTPPPPPPPPPPP 609
           + A  VPP+  S AP VPP     APP+P  GDSG   PP P  GDS  PP PP      
Sbjct: 591 SGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGA--PPVPPTGDSGAPPVPPTGDSGA 648

Query: 610 PPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPP 669
           PP+P      +PP  P G + +PP P +GDA  PP PP  +    P P +  G +  PP 
Sbjct: 649 PPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPT--GDSGAPPV 706

Query: 670 PPLPGSARIPPPP---------PPLPGSAGIPPPPPPLPGEAGMP 705
            P   S   P PP         PP   S   P PP     EA MP
Sbjct: 707 TPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMP 751



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 50/129 (38%), Positives = 57/129 (44%), Gaps = 18/129 (13%)

Query: 635 PLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPP 694
           P   D    P PP  +    P P   P G +   P P  G +  PP PP   G +G PP 
Sbjct: 553 PTVTDQEATPVPPTGDSEATPVP---PTGDSETAPVPPTGDSGAPPVPPT--GDSGAPPV 607

Query: 695 PPPLPGEAGMPPPPPP-LPGGPGIPP-----PPPFP--GGPGIPPPPP--GMGMPPPPPF 744
           PP   G++G PP PP    G P +PP      PP P  G  G PP PP    G PP PP 
Sbjct: 608 PPT--GDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 665

Query: 745 G-FGVPAAP 752
           G  G P  P
Sbjct: 666 GDSGAPPVP 674



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 41/109 (37%), Positives = 53/109 (48%), Gaps = 10/109 (9%)

Query: 558 AAAITVPPSVPSRAP-VPP-----APPLP--GDSGTIIPPPPAPGDSTTPPPPPPPPPPP 609
           + A  VPP+  S AP VPP     APP+P  GD+G   PP P  GDS  PP PP      
Sbjct: 646 SGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGP--PPVPPTGDSGAPPVPPTGDSGA 703

Query: 610 PPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPS 658
           PP+       + P  P G + +PP P +GD+   P PP  +      P+
Sbjct: 704 PPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPA 752



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 21/57 (36%), Positives = 21/57 (36%), Gaps = 2/57 (3%)

Query: 698 LPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPPG-MGMPPPPPFG-FGVPAAP 752
           LP        P P  G     P PP       P PP G  G PP PP G  G P  P
Sbjct: 552 LPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVP 608


>gi|162329583 cleavage and polyadenylation specific factor 6, 68 kD
           subunit [Homo sapiens]
          Length = 551

 Score =  112 bits (281), Expect = 2e-24
 Identities = 87/206 (42%), Positives = 92/206 (44%), Gaps = 47/206 (22%)

Query: 573 VPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISP 632
           VP     PG +G   PPPP P   T P PP  PP PP P PG      PP  P G  + P
Sbjct: 211 VPGGDRFPGPAGPGGPPPPFPAGQTPPRPPLGPPGPPGP-PG------PP--PPGQVLPP 261

Query: 633 P---PPLSGDATIPPPPPLPEG--VGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPG 687
           P   PP  GD   PPPP L  G   G P    LP G    PPPP+PG    P PPPP  G
Sbjct: 262 PLAGPPNRGDR--PPPPVLFPGQPFGQPPLGPLPPG----PPPPVPGYGPPPGPPPPQQG 315

Query: 688 SAGIPPPPPPLP----GEAGMP---PPPPPLPGGP-GIPPPPPF--------PGGPGIP- 730
               PPPP P P    G  G P    PPP LPG P G PPP P         P   G+P 
Sbjct: 316 P---PPPPGPFPPRPPGPLGPPLTLAPPPHLPGPPPGAPPPAPHVNPAFFPPPTNSGMPT 372

Query: 731 ------PPPPGMGMPPPPPFG-FGVP 749
                 PP    G PPP   G +G P
Sbjct: 373 SDSRGPPPTDPYGRPPPYDRGDYGPP 398



 Score =  107 bits (268), Expect = 6e-23
 Identities = 97/292 (33%), Positives = 117/292 (40%), Gaps = 45/292 (15%)

Query: 489 LQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELED 548
           L+++  +  ++ + K   L G      S+K      K++L  +   +T    +   + E 
Sbjct: 110 LEIKFFENRANGQSKGFALVGVGSEASSKKLMDLLPKRELHGQNPVVTPCNKQFLSQFEM 169

Query: 549 AKK---EMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPP 605
             +   +   +S      PP   SRA  P      G  G    P   PG    P P  P 
Sbjct: 170 QSRKTTQSGQMSGEGKAGPPGGSSRAAFPQ-----GGRGRGRFPGAVPGGDRFPGPAGPG 224

Query: 606 PPPPPPLPGGVCISSPPSLPGGTAISP---------PPPLSGD---ATIPPPPPLPEG-- 651
            PPP P P G     PP  P G    P         PPPL+G       PPPP L  G  
Sbjct: 225 GPPP-PFPAGQTPPRPPLGPPGPPGPPGPPPPGQVLPPPLAGPPNRGDRPPPPVLFPGQP 283

Query: 652 VGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPL----PGEAGMP-- 705
            G P    LP G    PPPP+PG     PPP P P   G PPPP P     PG  G P  
Sbjct: 284 FGQPPLGPLPPG----PPPPVPGYG---PPPGPPPPQQGPPPPPGPFPPRPPGPLGPPLT 336

Query: 706 -PPPPPLPG-GPGIPPPPPFPGGPGIPPPPPGMGMP------PPPPFGFGVP 749
             PPP LPG  PG PPP P    P   PPP   GMP      PPP   +G P
Sbjct: 337 LAPPPHLPGPPPGAPPPAPHV-NPAFFPPPTNSGMPTSDSRGPPPTDPYGRP 387



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 61/139 (43%), Positives = 65/139 (46%), Gaps = 16/139 (11%)

Query: 621 PPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPP 680
           P ++PGG     P    G     PPPP P G   P P   P G   PP PP PG   +PP
Sbjct: 208 PGAVPGGDRFPGPAGPGG-----PPPPFPAGQTPPRPPLGPPGPPGPPGPPPPGQV-LPP 261

Query: 681 PPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPG-GPGIPPPPPGMGMP 739
           P    P     PPPP   PG+    PP  PLP G    PPPP PG GP   PPPP  G P
Sbjct: 262 PLAGPPNRGDRPPPPVLFPGQPFGQPPLGPLPPG----PPPPVPGYGPPPGPPPPQQGPP 317

Query: 740 PPP-PFGFGVPAAPVLPFG 757
           PPP PF    P  P  P G
Sbjct: 318 PPPGPF----PPRPPGPLG 332



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 66/166 (39%), Positives = 70/166 (42%), Gaps = 26/166 (15%)

Query: 627 GTAISPPPPLSGDATIPP--------PPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARI 678
           G   + PP  S  A  P         P  +P G   P P+  PGG    PPPP P     
Sbjct: 182 GEGKAGPPGGSSRAAFPQGGRGRGRFPGAVPGGDRFPGPAG-PGG----PPPPFPAGQTP 236

Query: 679 PPPP---PPLPGSAGIPPP----PPPL---PGEAGMPPPPPPLPGGP-GIPPPPPFPGGP 727
           P PP   P  PG  G PPP    PPPL   P     PPPP   PG P G PP  P P GP
Sbjct: 237 PRPPLGPPGPPGPPGPPPPGQVLPPPLAGPPNRGDRPPPPVLFPGQPFGQPPLGPLPPGP 296

Query: 728 GIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRP 773
             PPP PG G PP PP     P  P  PF   P     P + L  P
Sbjct: 297 --PPPVPGYGPPPGPPPPQQGPPPPPGPFPPRPPGPLGPPLTLAPP 340



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 31/83 (37%), Positives = 35/83 (42%), Gaps = 10/83 (12%)

Query: 564 PPSVPSRAPVPPAPPLP-GDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPP 622
           PP  P   P PP PP P G   T+ PPP  PG       PPP  PPP P         P 
Sbjct: 316 PPPPPG--PFPPRPPGPLGPPLTLAPPPHLPG-------PPPGAPPPAPHVNPAFFPPPT 366

Query: 623 SLPGGTAISPPPPLSGDATIPPP 645
           +    T+ S  PP +     PPP
Sbjct: 367 NSGMPTSDSRGPPPTDPYGRPPP 389



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 26/72 (36%), Positives = 30/72 (41%), Gaps = 6/72 (8%)

Query: 564 PPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPP-PPPPPP--PPPPLPGGVCISS 620
           PP +P   P  P PP P  +    PPP   G  T+    PPP  P   PPP   G     
Sbjct: 340 PPHLPGPPPGAP-PPAPHVNPAFFPPPTNSGMPTSDSRGPPPTDPYGRPPPYDRG--DYG 396

Query: 621 PPSLPGGTAISP 632
           PP     TA +P
Sbjct: 397 PPGREMDTARTP 408


>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
          Length = 416

 Score =  111 bits (278), Expect = 4e-24
 Identities = 91/251 (36%), Positives = 100/251 (39%), Gaps = 62/251 (24%)

Query: 564 PPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPS 623
           PP   ++   PP+PP     G    PPP  G+    PPPPP  P  PP  GG     PP 
Sbjct: 40  PPQGGNKPQGPPSPP-----GKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPP- 93

Query: 624 LPGGTAISPPPPLSGDATIPP--PPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPP 681
            P G    PPP   GD +  P  PP  P+G   P P    GG     PPP PG  + PPP
Sbjct: 94  -PPGKPQGPPP--QGDKSRSPRSPPGKPQG---PPPQ---GGNQPQGPPPPPGKPQGPPP 144

Query: 682 P-------PPLPGSAGIPPP-----------PP-----PLPGEAGMPPPPPPLPGGPGIP 718
                   PP PG    PPP           PP     P P     P  PPP PG P  P
Sbjct: 145 QGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGP 204

Query: 719 PP--------PPFPGGPGIPPP-----------PPGMGMPPPPPFG---FGVPAAPVLPF 756
           PP        PP PG P  PPP           PPG    PPP  G    G P  P  P 
Sbjct: 205 PPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQ 264

Query: 757 GLTPKKLYKPE 767
           G  P+   KP+
Sbjct: 265 GPPPQGGNKPQ 275



 Score =  105 bits (263), Expect = 2e-22
 Identities = 90/269 (33%), Positives = 95/269 (35%), Gaps = 70/269 (26%)

Query: 564 PPSVPSRAPV-----PPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCI 618
           PP  P   P      P  PP PG        PP  GD +  P  PP  P  PP  GG   
Sbjct: 74  PPGKPQGPPPQGGNKPQGPPPPGKP----QGPPPQGDKSRSPRSPPGKPQGPPPQGGNQP 129

Query: 619 SSPPSLPGGTAISPPPPLSGDATIPPPPPLPEG---------------VGIPSPSSLPGG 663
             PP  PG     PPP        PPPP  P+G                G P      GG
Sbjct: 130 QGPPPPPGKPQ-GPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGG 188

Query: 664 TAIPPPPPLPGSARIPPPP-------PPLPGSAGIPPP-----------PP-----PLPG 700
                PPP PG  + PPP        PP PG    PPP           PP     P P 
Sbjct: 189 NQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQ 248

Query: 701 EAGMPPPPPPLPGGPGIPPP--------PPFPGGPGIPPP-----------PPGMGMPPP 741
               P  PPP PG P  PPP        PP PG P  PPP           PPG    PP
Sbjct: 249 GGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPP 308

Query: 742 PPFG---FGVPAAPVLPFGLTPKKLYKPE 767
           P  G    G P  P  P G  P+   KP+
Sbjct: 309 PQGGNQPQGPPPPPGKPQGPPPQGGNKPQ 337



 Score =  101 bits (252), Expect = 4e-21
 Identities = 79/223 (35%), Positives = 82/223 (36%), Gaps = 44/223 (19%)

Query: 568 PSRAPVPPAPPL--PGDSGTIIPPPPAPGDSTTPPP-----------PPPPPPPPPPLPG 614
           P   P PP  P   P   G     PP PG    PPP           PP  P  PPP  G
Sbjct: 129 PQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGG 188

Query: 615 GVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPP-----P 669
                 PP  P G    PPP        PPPP  P+G   P   +       PP     P
Sbjct: 189 NQPQGPPP--PPGKPQGPPPQGGNKPQGPPPPGKPQGPP-PQGDNKSQSARSPPGKPQGP 245

Query: 670 PPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGG--------------- 714
           PP  G+    PPPPP     G P  PPP  G     PPPP  P G               
Sbjct: 246 PPQGGNQPQGPPPPP-----GKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSP 300

Query: 715 PGIPPPPPFPGG--PGIPPPPPGMGMPPPPPFGFGVPAAPVLP 755
           PG P  PP  GG  P  PPPPPG    PPP  G   P  P  P
Sbjct: 301 PGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQ-GGNKPQGPPPP 342



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 78/227 (34%), Positives = 83/227 (36%), Gaps = 45/227 (19%)

Query: 568 PSRAPVPPAPPL--PGDSGTIIPPPPAPGDSTTPPP-----------PPPPPPPPPPLPG 614
           P   P PP  P   P   G     PP PG    PPP           PP  P  PPP  G
Sbjct: 191 PQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGG 250

Query: 615 GVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPP-----P 669
                 PP  P G    PPP        PPPP  P+G   P   S    +  PP     P
Sbjct: 251 NQPQGPPP--PPGKPQGPPPQGGNKPQGPPPPGKPQGPP-PQGGSKSRSSRSPPGKPQGP 307

Query: 670 PPLPGSARIPPPPPP-----LPGSAGIPPPPPPLPGEAGMPPP-----------PPPLPG 713
           PP  G+    PPPPP      P   G  P  PP PG+   PPP           PP  P 
Sbjct: 308 PPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQ 367

Query: 714 GPGIP-------PPPPFPGGPGIP-PPPPGMGMPPPPPFGFGVPAAP 752
           GP          PPPP  G P  P  PP G    PP P   G P+ P
Sbjct: 368 GPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRP 414



 Score = 95.1 bits (235), Expect = 4e-19
 Identities = 79/237 (33%), Positives = 87/237 (36%), Gaps = 60/237 (25%)

Query: 564 PPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCIS--SP 621
           PP   ++   PP PP     G    PPP  G+    PPPP  P  PPP       S  SP
Sbjct: 184 PPQGGNQPQGPPPPP-----GKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSP 238

Query: 622 PSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPP 681
           P  P G     PPP  G+    PPPP  +  G P     P G   P  PP PG  + PPP
Sbjct: 239 PGKPQG-----PPPQGGNQPQGPPPPPGKPQGPP-----PQGGNKPQGPPPPGKPQGPPP 288

Query: 682 ------------------PPPLPGSAGIPPPPPP-----LPGEAGMPPPPPPLPGGPGIP 718
                             PPP  G+    PPPPP      P + G  P  PP PG P  P
Sbjct: 289 QGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGP 348

Query: 719 PP------------------PPFPGG--PGIPPPPPGMGMPPPPPFGFGVPAAPVLP 755
           PP                  PP   G  P  PPPP G     P     G P  P  P
Sbjct: 349 PPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQPQGPPRP 405



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 65/189 (34%), Positives = 66/189 (34%), Gaps = 39/189 (20%)

Query: 568 PSRAPVPPAPPL--PGDSGTIIPPPPAPGDSTTPPP-----------PPPPPPPPPPLPG 614
           P   P PP  P   P   G     PP PG    PPP           PP  P  PPP  G
Sbjct: 253 PQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGG 312

Query: 615 GVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPG 674
                 PP  P G    PPP        PPPP  P+G                 PPP  G
Sbjct: 313 NQPQGPPP--PPGKPQGPPPQGGNKPQGPPPPGKPQG-----------------PPPQGG 353

Query: 675 SARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPP 734
           S       PP     G P  PP   G      PPPP  G P  P  PP  G P  PP PP
Sbjct: 354 SKSRSARSPP-----GKPQGPPQQEGN-NPQGPPPPAGGNPQQPQAPP-AGQPQGPPRPP 406

Query: 735 GMGMPPPPP 743
             G P  PP
Sbjct: 407 QGGRPSRPP 415



 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 69/191 (36%), Positives = 74/191 (38%), Gaps = 51/191 (26%)

Query: 622 PSLPGGTAISPPPPLSGDATIPPPPP-LPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPP 680
           PSL  G     PP        PP PP  P+G   P P    GG     PPP PG  + PP
Sbjct: 29  PSLIAGNPQGAPPQGGNKPQGPPSPPGKPQG---PPPQ---GGNQPQGPPPPPGKPQGPP 82

Query: 681 PP-------PPLPGSAGIPPP-------PPPLPGEAGMPPP--------PPPLPGGPGIP 718
           P        PP PG    PPP       P   PG+   PPP        PPP PG P  P
Sbjct: 83  PQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGP 142

Query: 719 PP--------PPFPGGPGIPPP-----------PPGMGMPPPPPFG---FGVPAAPVLPF 756
           PP        PP PG P  PPP           PPG    PPP  G    G P  P  P 
Sbjct: 143 PPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQ 202

Query: 757 GLTPKKLYKPE 767
           G  P+   KP+
Sbjct: 203 GPPPQGGNKPQ 213


>gi|153792074 proline rich 12 [Homo sapiens]
          Length = 2036

 Score =  109 bits (272), Expect = 2e-23
 Identities = 99/309 (32%), Positives = 129/309 (41%), Gaps = 76/309 (24%)

Query: 518  KQQIATEKQDLEAEVSQL-TGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPA 576
            +++I  + +++E +  ++ +G +A     L+  K+    L  A +T P S P    VPP+
Sbjct: 1260 REKIEAKIKEVEEKQPEMKSGFMASFLDFLKSGKRH-PPLYQAGLTPPLSPPKS--VPPS 1316

Query: 577  PPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPG----------GVCISSP----- 621
             P  G    + P PPA     TP  P PPP     L G          G+   SP     
Sbjct: 1317 VPARG----LQPQPPA-----TPAVPHPPPSGAFGLGGALEAAESEGLGLGCPSPCKRLD 1367

Query: 622  -------PSLPG-------------------GTAISP--PPPLSG--DATIPPPPPLPEG 651
                    +LP                     +AIS    PPL+G  D + P  PPL   
Sbjct: 1368 EELKRNLETLPSFSSDEEDSVAKNRDLQESISSAISALDDPPLAGPKDTSTPDGPPLAPA 1427

Query: 652  VGIPSPSSLPG-----GTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPP 706
              +P P  LPG         P PP L    + PP PPP P     PPPPPP P +  +P 
Sbjct: 1428 AAVPGPPPLPGLPSANSNGTPEPPLL--EEKPPPTPPPAPTPQPQPPPPPP-PPQPALPS 1484

Query: 707  PPPPLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVP--AAPVLPFGLTPKKLY 764
            PPP +   P  PPPPP P     PPPPP M  PPPPP     P  A P  P   +P+   
Sbjct: 1485 PPPLVAPTPSSPPPPPLP-----PPPPPAMPSPPPPPPPAAAPLAAPPEEPAAPSPE--- 1536

Query: 765  KPEVQLRRP 773
             PE+   RP
Sbjct: 1537 DPELPDTRP 1545



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 71/220 (32%), Positives = 97/220 (44%), Gaps = 56/220 (25%)

Query: 494  KKMESDFEQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEM 553
            K+++ + ++ L+ L     +  S+++    + +DL+  +S            L+D     
Sbjct: 1364 KRLDEELKRNLETLP----SFSSDEEDSVAKNRDLQESISSAISA-------LDDPP--- 1409

Query: 554  ASLSAAAITVPPSVPSRAP---VPPAPPLPG-----DSGTIIPP------PPAPGDSTTP 599
              L+    T  P  P  AP   VP  PPLPG      +GT  PP      PP P  + TP
Sbjct: 1410 --LAGPKDTSTPDGPPLAPAAAVPGPPPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPTP 1467

Query: 600  PPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSS 659
             P PPPPPPPP           P+LP     SPPP ++   + PPPPPLP     P P +
Sbjct: 1468 QPQPPPPPPPPQ----------PALP-----SPPPLVAPTPSSPPPPPLPP----PPPPA 1508

Query: 660  LPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLP 699
            +P      PPPP P +A     PP  P  A   P  P LP
Sbjct: 1509 MPS-----PPPPPPPAAAPLAAPPEEP--AAPSPEDPELP 1541



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 62/209 (29%), Positives = 81/209 (38%), Gaps = 30/209 (14%)

Query: 598 TPPPPPPPPPPPPPLPGGVCI-SSPPSLPGGTAISPPPP-----LSGDATIPPPPPLPEG 651
           +PPPPPP      P P G+ + +  P LP    + PPPP     +   A  P P     G
Sbjct: 763 SPPPPPPTAQSTQPTPHGLLLEAGGPDLP--LVLPPPPPQLLPSVLSHAPSPSPSASKVG 820

Query: 652 VGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLP-------GSAGIPP--PPPPLPGEA 702
           V +  P++  G    PPPP        PPPPPP+P        S G+ P  P P L  E 
Sbjct: 821 VHLLEPATRDGAPQPPPPP--------PPPPPPMPLQLEAHLRSHGLEPAAPSPRLRPEE 872

Query: 703 GMPPPPPPLPGGPGIPPPPPFPGGPGIPPP-----PPGMGMPPPPPFGFGVPAAPVLPFG 757
            + PP         + P PP PG  G+ PP      P      P P G   P    L   
Sbjct: 873 SLDPPGAMQELLGALEPLPPAPGDTGVGPPNSEGKDPAGAYRSPSPQGTKAPRFVPLTSI 932

Query: 758 LTPKKLYKPEVQLRRPNWSKLVAEDLSQD 786
             P  L + E +   P   ++     + D
Sbjct: 933 CFPDSLLQDEERSFFPTMEEMFGGGAADD 961



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 65/244 (26%), Positives = 86/244 (35%), Gaps = 59/244 (24%)

Query: 565  PSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTP-------------PPPPPPPPPPPP 611
            P +P   P PP   LP    +++   P+P  S +               P PPPPPPPPP
Sbjct: 788  PDLPLVLPPPPPQLLP----SVLSHAPSPSPSASKVGVHLLEPATRDGAPQPPPPPPPPP 843

Query: 612  LPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSP-SSLPGGTAIPPPP 670
             P  + + +     G    +P P L  + ++ PP  + E +G   P    PG T + PP 
Sbjct: 844  PPMPLQLEAHLRSHGLEPAAPSPRLRPEESLDPPGAMQELLGALEPLPPAPGDTGVGPPN 903

Query: 671  PL---PGSARIPPPPPPLPGSAGIPPPPPPLP---------------------------G 700
                 P  A   P P        +P      P                           G
Sbjct: 904  SEGKDPAGAYRSPSPQGTKAPRFVPLTSICFPDSLLQDEERSFFPTMEEMFGGGAADDYG 963

Query: 701  EAGMPPPPPPLPGGPGIPPPPPF--PGGP-------GIPPPPPGMGMPP--PPPFGFGVP 749
            +AG P        G G PP PP   P GP       G  P  PG+G+ P  PP     V 
Sbjct: 964  KAGPPEDEGDPKAGAGPPPGPPAYDPYGPYCPGRASGAGPETPGLGLDPNKPPELPSTVN 1023

Query: 750  AAPV 753
            A P+
Sbjct: 1024 AEPL 1027



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 48/163 (29%), Positives = 57/163 (34%), Gaps = 48/163 (29%)

Query: 588 PPPPAPGDSTTPPPP----------------PPPPPP---------PPPLPG----GVCI 618
           PPPP P   +T P P                PPPPP          P P P     GV +
Sbjct: 764 PPPPPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVHL 823

Query: 619 SSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGV-----------GIPSPSSLPGGTAIP 667
             P +  G     PPPP       PPPPP+P  +             PSP   P   ++ 
Sbjct: 824 LEPATRDGAPQPPPPPP-------PPPPPMPLQLEAHLRSHGLEPAAPSPRLRPE-ESLD 875

Query: 668 PPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPP 710
           PP  +        P PP PG  G+ PP       AG    P P
Sbjct: 876 PPGAMQELLGALEPLPPAPGDTGVGPPNSEGKDPAGAYRSPSP 918



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 55/190 (28%), Positives = 67/190 (35%), Gaps = 39/190 (20%)

Query: 568 PSRAP-VPPAPPLPGDSGTIIPPPPAPGDSTTPP---PPPPPPPPPPPLPGGVCISSPPS 623
           PS+AP VP +      +G  +  P   G + TPP    PP PPPPP  LP    + +  S
Sbjct: 193 PSQAPTVPSSLGFERLAGGGVLGPAGLGPAQTPPYRPGPPDPPPPPRHLPTQFNLLASSS 252

Query: 624 LPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPP 683
                A    P L   +   P PP PE        +LP    +      P SA+ PPPPP
Sbjct: 253 AAAAAAEQSSPQLYNFSGAAPGPPPPE-------RALPRQDTVIKHYQRPASAQPPPPPP 305

Query: 684 PL-------------------------PGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIP 718
           P                          P   G P P    P +AG   P     G  G  
Sbjct: 306 PAHALQHYLSCGGSYPSMGHRANLACSPLGGGEPSPGAGEPSKAG---PSGATAGASGRA 362

Query: 719 PPPPFPGGPG 728
             P   GG G
Sbjct: 363 TGPEAAGGGG 372



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 67/231 (29%), Positives = 76/231 (32%), Gaps = 60/231 (25%)

Query: 584  GTIIPPPPAPGDSTTPPP-------------PPPPPPPPPPLPGGVCISSPPSL------ 624
            G + P PPAPGD+   PP             P P     P       I  P SL      
Sbjct: 885  GALEPLPPAPGDTGVGPPNSEGKDPAGAYRSPSPQGTKAPRFVPLTSICFPDSLLQDEER 944

Query: 625  ----------PGGTAI----SPPPPLSGD----ATIPPPPPLPEGVGIPSPSSLPGGTAI 666
                       GG A     + PP   GD    A  PP PP  +  G   P     G A 
Sbjct: 945  SFFPTMEEMFGGGAADDYGKAGPPEDEGDPKAGAGPPPGPPAYDPYGPYCP-----GRAS 999

Query: 667  PPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGG 726
               P  PG    P  PP LP +    P      G     PPPPP       PPPPP P  
Sbjct: 1000 GAGPETPGLGLDPNKPPELPSTVNAEPLGLIQSGPHQAAPPPPP------PPPPPPAPAS 1053

Query: 727  PGIPPPPPGMGMP----PPPPFGFGVPAAPVL----PFGLTPKKLYKPEVQ 769
                 P  G+  P      P       +  +L    P   TPKKLY  E +
Sbjct: 1054 ----EPKGGLTSPIFCSTKPKKLLKTSSFHLLRRRDPPFQTPKKLYAQEYE 1100



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 58/200 (29%), Positives = 64/200 (32%), Gaps = 51/200 (25%)

Query: 592 APGDSTTPPPPPPPPPPPPPLPGGVCI------SSPPSLPGGTAISPPPPLSGDATIPPP 645
           A G +T PPPP     P     GG         +S     GG A SP  P      +  P
Sbjct: 399 AAGGATRPPPPRSTATPKCQSLGGPAAAYATGKASGAGGAGGQAYSPGQPQG----LLGP 454

Query: 646 PPLPEGVG------IPSPSSLPGGTAIPPP-PPLPGSARI-----------------PPP 681
               +G G      +    S  GG   PP  PP PG A                    P 
Sbjct: 455 QAYGQGFGGGQAQDLSKAPSYSGGPPQPPSGPPPPGLATCQSYSPDQLQGQLYGVQGEPY 514

Query: 682 PPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPP--------- 732
           P P   S G+P   P L    G  P      GG G    P   GG G   P         
Sbjct: 515 PGPAAHSQGLPTASPSLSYSTGHSPALSGHGGGWG----PSSLGGGGEASPSHIIRPLQS 570

Query: 733 PPGMGMPPPPPFGFGVPAAP 752
           PP  G PP    G G P AP
Sbjct: 571 PPATGRPP----GVGSPGAP 586



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 21/58 (36%), Positives = 25/58 (43%)

Query: 577  PPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPP 634
            PP+P         P + G S+ PPP  P PPP P  P       PP     TA+  PP
Sbjct: 1670 PPVPVRRSGQAKNPVSAGGSSAPPPKAPAPPPKPETPEKTTSEKPPEQTPETAMPEPP 1727



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 52/189 (27%), Positives = 62/189 (32%), Gaps = 29/189 (15%)

Query: 564  PPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGV-----CI 618
            PP +PS     P   +        PPPP       PPPPPPP P   P  GG+     C 
Sbjct: 1015 PPELPSTVNAEPLGLIQSGPHQAAPPPP-------PPPPPPPAPASEP-KGGLTSPIFCS 1066

Query: 619  SSPPSLPGGTAI----SPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPP--PPL 672
            + P  L   ++        PP      +       E       + +P    + P   P L
Sbjct: 1067 TKPKKLLKTSSFHLLRRRDPPFQTPKKLYAQE--YEFEADEDKADVPADIRLNPRRLPDL 1124

Query: 673  PGSARIPPPPPPLPGSAGIPP-PPPPLPGEAGMPPP------PPPLPGGPGIPP-PPPFP 724
              S R  P   PL      PP P P  P   G  P       PP   G P I P   P  
Sbjct: 1125 VSSCRSRPALSPLGDIDFCPPNPGPDGPRRRGRKPTKAKRDGPPRPRGRPRIRPLEVPTT 1184

Query: 725  GGPGIPPPP 733
             GP     P
Sbjct: 1185 AGPASASTP 1193



 Score = 40.8 bits (94), Expect = 0.008
 Identities = 50/175 (28%), Positives = 60/175 (34%), Gaps = 39/175 (22%)

Query: 593 PGDSTTPPP--------PPPPPPPPPPLPGGVCISSPP-SLPGGTAISPPPPLSGDATIP 643
           PG ST P          P      P P+P  + +  PP S P    +SP   L    +  
Sbjct: 137 PGSSTFPSSSALSAYQHPASFGSRPFPVPSSLSLQDPPFSPPANGLLSPHDVLHLKPSQA 196

Query: 644 PPPPLPEGV------GIPSPSSLPGGTAIPPPPPLPGSARIPPPPPP---LP-------- 686
           P  P   G       G+  P+ L G    PP  P P     P PPPP   LP        
Sbjct: 197 PTVPSSLGFERLAGGGVLGPAGL-GPAQTPPYRPGP-----PDPPPPPRHLPTQFNLLAS 250

Query: 687 ---GSAGIPPPPPPLPGEAGMPPPPPP----LPGGPGIPPPPPFPGGPGIPPPPP 734
               +A      P L   +G  P PPP    LP    +      P     PPPPP
Sbjct: 251 SSAAAAAAEQSSPQLYNFSGAAPGPPPPERALPRQDTVIKHYQRPASAQPPPPPP 305



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 32/99 (32%), Positives = 38/99 (38%), Gaps = 21/99 (21%)

Query: 574  PPAPPLPGDSGTIIPPPPAPGDSTTPPPPPP----PPPPPPPLPGGVCISSPPSLPGGTA 629
            PP PP     G     P  PG ++   P  P     P  PP LP  V       +  G  
Sbjct: 981  PPGPPAYDPYG-----PYCPGRASGAGPETPGLGLDPNKPPELPSTVNAEPLGLIQSGPH 1035

Query: 630  ISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPP 668
             + PPP       PPPPP P     P+P+S P G    P
Sbjct: 1036 QAAPPP-------PPPPPPP-----PAPASEPKGGLTSP 1062



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 24/67 (35%), Positives = 27/67 (40%), Gaps = 7/67 (10%)

Query: 644  PPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAG 703
            PP P+       +P S  G +A PP  P       PPP P  P       PP   P E  
Sbjct: 1670 PPVPVRRSGQAKNPVSAGGSSAPPPKAPA------PPPKPETPEKTTSEKPPEQTP-ETA 1722

Query: 704  MPPPPPP 710
            MP PP P
Sbjct: 1723 MPEPPAP 1729



 Score = 37.0 bits (84), Expect = 0.12
 Identities = 47/156 (30%), Positives = 50/156 (32%), Gaps = 33/156 (21%)

Query: 592 APGDSTTPPPPPPPPPPPPPLPGGVCIS-SPPSLPGGTAISPPPPLSGDATIPPPPPLPE 650
           AP  S  PP PP  PPPP       C S SP  L G         L G    P P P   
Sbjct: 472 APSYSGGPPQPPSGPPPPGL---ATCQSYSPDQLQG--------QLYGVQGEPYPGPAAH 520

Query: 651 GVGIPSPS-SLPGGTAIPP----------PPPLPGSARIPPPPPPLPGSAGIPPPPPPLP 699
             G+P+ S SL   T   P          P  L G           P     P   PP  
Sbjct: 521 SQGLPTASPSLSYSTGHSPALSGHGGGWGPSSLGGGGEAS------PSHIIRPLQSPPAT 574

Query: 700 GEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPPG 735
           G     PP    PG PG          P + PP  G
Sbjct: 575 GR----PPGVGSPGAPGKYLSSVLASAPFLAPPGAG 606



 Score = 36.6 bits (83), Expect = 0.16
 Identities = 30/114 (26%), Positives = 40/114 (35%), Gaps = 22/114 (19%)

Query: 643 PPPPPLPEGVGIPSPSSLPGGTAIPP----------PPPLPGSARIPPPPPPLPGSAGIP 692
           P P  L     +P  S+ P  +A+            P P+P S  +  PP   P +  + 
Sbjct: 125 PGPTELFISGALPGSSTFPSSSALSAYQHPASFGSRPFPVPSSLSLQDPPFSPPANGLLS 184

Query: 693 PPPPPLPGEAGMPPPPPPL------------PGGPGIPPPPPFPGGPGIPPPPP 734
           P        +  P  P  L            P G G    PP+  GP  PPPPP
Sbjct: 185 PHDVLHLKPSQAPTVPSSLGFERLAGGGVLGPAGLGPAQTPPYRPGPPDPPPPP 238



 Score = 35.4 bits (80), Expect = 0.35
 Identities = 31/100 (31%), Positives = 37/100 (37%), Gaps = 16/100 (16%)

Query: 676  ARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPP-- 733
            AR P   PP+P         P   G +  PPP  P P     PP P  P       PP  
Sbjct: 1663 ARKPWHRPPVPVRRSGQAKNPVSAGGSSAPPPKAPAP-----PPKPETPEKTTSEKPPEQ 1717

Query: 734  -PGMGMPPPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRR 772
             P   MP PP        AP  P  L P +  K + ++ R
Sbjct: 1718 TPETAMPEPP--------APEKPSLLRPVEKEKEKEKVTR 1749



 Score = 33.1 bits (74), Expect = 1.7
 Identities = 17/52 (32%), Positives = 23/52 (44%), Gaps = 3/52 (5%)

Query: 556  LSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPP 607
            +SA   + PP    +AP PP  P   +  T   PP    ++  P PP P  P
Sbjct: 1684 VSAGGSSAPPP---KAPAPPPKPETPEKTTSEKPPEQTPETAMPEPPAPEKP 1732



 Score = 32.0 bits (71), Expect = 3.8
 Identities = 24/87 (27%), Positives = 29/87 (33%), Gaps = 18/87 (20%)

Query: 616  VCISSP---PSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPL 672
            VC   P   P +P   +     P+S   +  PPP  P               A PP P  
Sbjct: 1661 VCARKPWHRPPVPVRRSGQAKNPVSAGGSSAPPPKAP---------------APPPKPET 1705

Query: 673  PGSARIPPPPPPLPGSAGIPPPPPPLP 699
            P       PP   P +A   PP P  P
Sbjct: 1706 PEKTTSEKPPEQTPETAMPEPPAPEKP 1732



 Score = 31.2 bits (69), Expect = 6.5
 Identities = 19/64 (29%), Positives = 22/64 (34%), Gaps = 6/64 (9%)

Query: 670  PPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGI 729
            PP+P         P   G +  PPP  P       PPP P  P       PP       +
Sbjct: 1670 PPVPVRRSGQAKNPVSAGGSSAPPPKAP------APPPKPETPEKTTSEKPPEQTPETAM 1723

Query: 730  PPPP 733
            P PP
Sbjct: 1724 PEPP 1727


>gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1
           preproprotein [Homo sapiens]
          Length = 331

 Score =  108 bits (270), Expect = 3e-23
 Identities = 85/231 (36%), Positives = 90/231 (38%), Gaps = 38/231 (16%)

Query: 568 PSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPP--------PPPPPPPPPPLPGGVCIS 619
           PS     P  P P        PPP PG    PPP        PPPP  P  P P G    
Sbjct: 29  PSLIAGNPQGPSPQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSR 88

Query: 620 SPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIP 679
           SP S PG      PPP  G+    PPPP  +  G P     P G   P  PP PG  + P
Sbjct: 89  SPRSPPGKP--QGPPPQGGNQPQGPPPPPGKPQGPP-----PQGGNRPQGPPPPGKPQGP 141

Query: 680 PPPPPLPGSAGIPPPPP--PLPGEAGMPPPPPPLPGGPGIPPP--------PPFPGGPGI 729
           PP      S   PP  P  P P     P  PPP PG P  PPP        PP PG P  
Sbjct: 142 PPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGKKPQGPPPPGKPQG 201

Query: 730 PPP----------PPGMGMPPPPPFG---FGVPAAPVLPFGLTPKKLYKPE 767
           PPP          PPG    PPP  G    G P  P  P G  P+   KP+
Sbjct: 202 PPPQGDKSRSSQSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQ 252



 Score =  107 bits (267), Expect = 7e-23
 Identities = 82/219 (37%), Positives = 87/219 (39%), Gaps = 41/219 (18%)

Query: 564 PPSVPSRAPV-----PPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCI 618
           PP  P   P      P  PP PG        PP  GD +  P  PP  P  PP  GG   
Sbjct: 53  PPGKPQGPPPQGGNKPQGPPPPGKP----QGPPPQGDKSRSPRSPPGKPQGPPPQGGNQP 108

Query: 619 SSPPSLPGGTAISPPPPLSGDATIPPPPP------LPEGVGIPSPSSLPGGTAIPPPPPL 672
             PP  PG      PPP  G+    PPPP       P+G    SP S PG      PPP 
Sbjct: 109 QGPPPPPGKP--QGPPPQGGNRPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQ--GPPPQ 164

Query: 673 PGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGP--------------GIP 718
            G+    PPPPP     G P  PPP  G+    PPPP  P GP              G P
Sbjct: 165 GGNQPQGPPPPP-----GKPQGPPPQGGKKPQGPPPPGKPQGPPPQGDKSRSSQSPPGKP 219

Query: 719 PPPPFPGG--PGIPPPPPGMGMPPPPPFGFGVPAAPVLP 755
             PP  GG  P  PPPPPG    PPP  G   P  P  P
Sbjct: 220 QGPPPQGGNQPQGPPPPPGKPQGPPPQ-GGNKPQGPPPP 257



 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 80/238 (33%), Positives = 85/238 (35%), Gaps = 57/238 (23%)

Query: 568 PSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPP--------PPPPPPPPPPLPGGVCIS 619
           P   P  P  P P        PPP PG    PPP        PPPP  P  P P G    
Sbjct: 90  PRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNRPQGPPPPGKPQGPPPQGDKSR 149

Query: 620 SPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIP 679
           SP S PG      PPP  G+    PPPP  +  G P     P G   P  PP PG  + P
Sbjct: 150 SPRSPPGKP--QGPPPQGGNQPQGPPPPPGKPQGPP-----PQGGKKPQGPPPPGKPQGP 202

Query: 680 PP-----------------PPPLPGSAGIPPPPPP-----LPGEAGMPPPPPPLPGGPGI 717
           PP                 PPP  G+    PPPPP      P + G  P  PP PG P  
Sbjct: 203 PPQGDKSRSSQSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQG 262

Query: 718 PP------------PPPFPGGPGI--------PPPPPGMGMPPPPPFGFGVPAAPVLP 755
           PP            PP  P GP          PPPP G     P     G P  P  P
Sbjct: 263 PPAQGGSKSQSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQPQGPPRP 320



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 67/184 (36%), Positives = 72/184 (39%), Gaps = 18/184 (9%)

Query: 564 PPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPS 623
           PP      P  P PP     G   PPP        PPPP  P  PPP         SPP 
Sbjct: 161 PPPQGGNQPQGPPPPPGKPQG---PPPQGGKKPQGPPPPGKPQGPPPQGDKSRSSQSPPG 217

Query: 624 LPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPP 683
            P G     PPP  G+    PPPP  +  G P     P G   P  PP PG  + PP   
Sbjct: 218 KPQG-----PPPQGGNQPQGPPPPPGKPQGPP-----PQGGNKPQGPPPPGKPQGPPAQG 267

Query: 684 PLPGSAGIPPPPPPL--PGEAGMPP--PPPPLPGGPGIPPPPPFPGGPGIPPPPPGMGMP 739
                +   PP  P   P + G  P  PPPP  G P  P  PP  G P  PP PP  G P
Sbjct: 268 GSKSQSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPP-AGQPQGPPRPPQGGRP 326

Query: 740 PPPP 743
             PP
Sbjct: 327 SRPP 330



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 55/168 (32%), Positives = 59/168 (35%), Gaps = 60/168 (35%)

Query: 656 SPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPP-------PPLPGEAGMPPP- 707
           SPS + G     P  P P     P  PPP PG    PPP        PP PG+   PPP 
Sbjct: 28  SPSLIAGN----PQGPSPQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQ 83

Query: 708 ---------------------------PPPLPGGPGIPPP--------PPFPGGPGIPPP 732
                                      PPP PG P  PPP        PP PG P  PPP
Sbjct: 84  GDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNRPQGPPPPGKPQGPPP 143

Query: 733 ----------PPGMGMPPPPPFG---FGVPAAPVLPFGLTPKKLYKPE 767
                     PPG    PPP  G    G P  P  P G  P+   KP+
Sbjct: 144 QGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGKKPQ 191


>gi|122937496 WAS/WASL interacting protein family, member 3 [Homo
           sapiens]
          Length = 483

 Score =  108 bits (269), Expect = 4e-23
 Identities = 76/210 (36%), Positives = 80/210 (38%), Gaps = 42/210 (20%)

Query: 559 AAITVPPSVPSRAPVPPA---------PPLPGDSGTIIPPPPAPGDST------------ 597
           AA T PP     AP PP          PPLP  S    P    PG  T            
Sbjct: 161 AARTAPPRPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVP 220

Query: 598 --TPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIP 655
              PPPPPPPPP PPPLP    +S     P    +  PP       IPPP PL    G P
Sbjct: 221 CAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPP-------IPPPLPLLPPCGYP 273

Query: 656 SPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPP----PPPPLPGEAGMPPPPPPL 711
                  G    P  P   +   P PPPPLP  A   P    P PPLPG       PPPL
Sbjct: 274 -------GLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPL 326

Query: 712 -PGGPGIPPPPPFPGGPGIPPPPPGMGMPP 740
            P  P    PP   G   +P PP   G  P
Sbjct: 327 PPKSPSFQAPPQKAGAQALPAPPAPPGSQP 356



 Score =  102 bits (253), Expect = 3e-21
 Identities = 80/231 (34%), Positives = 100/231 (43%), Gaps = 50/231 (21%)

Query: 563 VPPSVPSRAPVPPAPPLPGDS----GTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCI 618
           +P    S   +PPA P  G++    G     PP P  +   PPPP PPPPPPPLP  +  
Sbjct: 135 LPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRP--NVPAPPPPTPPPPPPPLPPPLPS 192

Query: 619 SSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARI 678
           SSP   P    +SPP PL+        PP+P               A PPPPP P     
Sbjct: 193 SSPIKTP---LVSPPGPLTKGNLPVVAPPVP--------------CAPPPPPPPP----- 230

Query: 679 PPPPPPLPGSA-----GIPPPPPPLPGEAGMPPPPPPLP-----GGPGIPPPPPFPGGPG 728
           PP PPPLP ++      + P   PL     +PP PPPLP     G PG+   P  P    
Sbjct: 231 PPTPPPLPPASVLSDKAVKPQLAPLH----LPPIPPPLPLLPPCGYPGLKAEPASPAQDA 286

Query: 729 IPPPPPGMGMPPPPPFGFGVP----AAPVLPFGLTPKKLYKPEVQLRRPNW 775
             PP P    PP PP+    P     AP LP G+       P +  + P++
Sbjct: 287 QEPPAPP---PPLPPYASCSPRASLPAPPLP-GVNSSSETPPPLPPKSPSF 333



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 64/195 (32%), Positives = 71/195 (36%), Gaps = 31/195 (15%)

Query: 555 SLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPP--PPPPPPPL 612
           +L   A  VP + P   P PP  P P      +PP     D    P   P   PP PPPL
Sbjct: 211 NLPVVAPPVPCAPPPPPPPPPPTPPP------LPPASVLSDKAVKPQLAPLHLPPIPPPL 264

Query: 613 PGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPL 672
           P    +  P   PG  A    P         PPPPLP        +SLP        PPL
Sbjct: 265 P----LLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPA-------PPL 313

Query: 673 PGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPP--------PPPFP 724
           PG       PPPLP  +     PP   G   +P PP P    PG  P         P   
Sbjct: 314 PGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAP----PGSQPFLQKKRHGRPGAG 369

Query: 725 GGPGIPPPPPGMGMP 739
           GG   PPP P    P
Sbjct: 370 GGKLNPPPAPPARSP 384



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 81/259 (31%), Positives = 93/259 (35%), Gaps = 93/259 (35%)

Query: 572 PVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPL------PGG---------- 615
           PVPP PP P      +PPPP P  +  PPPP  PP            P G          
Sbjct: 2   PVPPPPPPP------LPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQ 55

Query: 616 ---------VCISSPPSLP---------GGTAI---SPPPPLSGDATIPPPPPL------ 648
                    +   S P +          GG+A    +  PP  GD      P L      
Sbjct: 56  GTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQR 115

Query: 649 -------PEGVGIPSPS-SLP----GGTAIPPPPP-------LPGSARIPPPPPPLPGSA 689
                   +G G  +PS  LP     G  IPP  P         G+AR  PP P +P   
Sbjct: 116 DVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPP 175

Query: 690 GIPPPPPPLPGEAGMPPPPPPLPGG-----PGIPPPPPFPGG---------PGIPPPPPG 735
              PPPPP       PP PPPLP       P + PP P   G         P  PPPPP 
Sbjct: 176 PPTPPPPP-------PPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPP- 227

Query: 736 MGMPPPPPFGFGVPAAPVL 754
              PPPPP    +P A VL
Sbjct: 228 ---PPPPPTPPPLPPASVL 243



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 64/187 (34%), Positives = 74/187 (39%), Gaps = 37/187 (19%)

Query: 590 PPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPP--PP 647
           PP  GD      P   P     + GG     P    G  A SP  P   + TI  P  PP
Sbjct: 95  PPTLGDLFAGGFPVLRPAGQRDVAGGKTGQGP----GSRAPSPRLP---NKTISGPLIPP 147

Query: 648 LPEGVGIPSPSSLPGGTAIP------PPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGE 701
               +G  S +     TA P      PPPP P     PPPPPPLP     PP P   P +
Sbjct: 148 ASPRLGNTSEAHGAARTAPPRPNVPAPPPPTP-----PPPPPPLP-----PPLPSSSPIK 197

Query: 702 AGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPK 761
             +  PP PL  G      PP P  P  PPPPP    PP PP        P+ P  +   
Sbjct: 198 TPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPP----PPTPP--------PLPPASVLSD 245

Query: 762 KLYKPEV 768
           K  KP++
Sbjct: 246 KAVKPQL 252



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 34/114 (29%), Positives = 42/114 (36%), Gaps = 26/114 (22%)

Query: 564 PPSVPSRAPVPP-----APPLPGDSGTIIPPPPAP-------------GDSTTPPPPPPP 605
           PP +P  A   P     APPLPG + +   PPP P             G    P PP PP
Sbjct: 293 PPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPP 352

Query: 606 PPPP--------PPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEG 651
              P         P  GG  ++ PP+ P  +  +     S  AT   P   P G
Sbjct: 353 GSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQATAWTPTQQPGG 406



 Score = 35.0 bits (79), Expect = 0.45
 Identities = 14/27 (51%), Positives = 15/27 (55%)

Query: 729 IPPPPPGMGMPPPPPFGFGVPAAPVLP 755
           +PPPPP    PPPPP G   P  P  P
Sbjct: 3   VPPPPPPPLPPPPPPLGAPPPPPPSAP 29


>gi|4826998 splicing factor proline/glutamine rich (polypyrimidine
           tract binding protein associated) [Homo sapiens]
          Length = 707

 Score =  108 bits (269), Expect = 4e-23
 Identities = 81/208 (38%), Positives = 90/208 (43%), Gaps = 36/208 (17%)

Query: 569 SRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPP--PPP--PPPLPGGVCISSPPSL 624
           +R P+ P P   G    I PPPP       PP  PPP  PPP  PPP P       PP  
Sbjct: 43  NRGPMGPGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQPPPHPQPHQQQQPPPP 102

Query: 625 PGGTA----ISPPPPLSGDATIPP-----PPPLPEGVGIPSPSSLPGGTAIPPPPPLPGS 675
           P  ++       P P  G  + PP     PP  P   G P P S PG    P P P P  
Sbjct: 103 PQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAP-PGSGPG----PTPTPPPAV 157

Query: 676 ARIPP-PPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGI-PPPPPFPGG------P 727
              PP  PPP P S+G+P  PP    +AG PPPPP    GPG  P   P PGG      P
Sbjct: 158 TSAPPGAPPPTPPSSGVPTTPP----QAGGPPPPPAAVPGPGPGPKQGPGPGGPKGGKMP 213

Query: 728 GIPPPPPGMGM------PPPPPFGFGVP 749
           G P P  G G+      P PP  G G P
Sbjct: 214 GGPKPGGGPGLSTPGGHPKPPHRGGGEP 241



 Score = 97.8 bits (242), Expect = 6e-20
 Identities = 76/222 (34%), Positives = 86/222 (38%), Gaps = 44/222 (19%)

Query: 565 PSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPP---------PPPPPPLPGG 615
           P      P PP PP P       PPP  P     PP  PPP         PPPPP     
Sbjct: 49  PGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQPPPHPQPHQQQQPPPPPQDSSK 108

Query: 616 VCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGI-PSPSSLPGGTAIPP--PPPL 672
             ++  P    G   +PP   S     PP    P G G  P+P+  P  T+ PP  PPP 
Sbjct: 109 PVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPT 168

Query: 673 PGSARIPPPPPPLPGSAGIPPPPP-------------PLPG--EAGMPPPPPPLPGGPGI 717
           P S+ +P  PP     AG PPPPP             P PG  + G  P  P   GGPG+
Sbjct: 169 PPSSGVPTTPP----QAGGPPPPPAAVPGPGPGPKQGPGPGGPKGGKMPGGPKPGGGPGL 224

Query: 718 P-----PPPPFPGGPGIP-------PPPPGMGMPPPPPFGFG 747
                 P PP  GG G P       PP        PPP G G
Sbjct: 225 STPGGHPKPPHRGG-GEPRGGRQHHPPYHQQHHQGPPPGGPG 265



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 58/163 (35%), Positives = 65/163 (39%), Gaps = 35/163 (21%)

Query: 608 PPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIP--SPSSLPGGTA 665
           PPP +  G+  +  P  PG     P PP      IPPPPP  +    P   P        
Sbjct: 34  PPPGM--GLNQNRGPMGPGPGQSGPKPP------IPPPPPHQQQQQPPPQQPPPQQPPPH 85

Query: 666 IPPPPPLPGSARIPPPPP-------------PLPGSAGIPP----PPPPLPGEAGMP--- 705
            PPP P P   + PPPPP             P PG    PP     PP  P  +G P   
Sbjct: 86  QPPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGS 145

Query: 706 ---PPPPPLPGGPGIPP--PPPFPGGPGIPPPPPGMGMPPPPP 743
              P P P P     PP  PPP P   G+P  PP  G PPPPP
Sbjct: 146 GPGPTPTPPPAVTSAPPGAPPPTPPSSGVPTTPPQAGGPPPPP 188



 Score = 71.2 bits (173), Expect = 6e-12
 Identities = 54/162 (33%), Positives = 59/162 (36%), Gaps = 40/162 (24%)

Query: 631 SPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAG 690
           SPPP +  +    P  P P   G   P        IPPPPP     + PP  PP      
Sbjct: 33  SPPPGMGLNQNRGPMGPGPGQSGPKPP--------IPPPPPHQQQQQPPPQQPPPQQPPP 84

Query: 691 IPPPPPPLPGEAGMPPPPP-------------PLPGGPGIPP-----PPPFPGGPGIPP- 731
             PPP P P +   PPPPP             P PG    PP     PP  P   G PP 
Sbjct: 85  HQPPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPG 144

Query: 732 --------PPPGM-----GMPPPPPFGFGVPAAPVLPFGLTP 760
                   PPP +     G PPP P   GVP  P    G  P
Sbjct: 145 SGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPTTPPQAGGPPP 186



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 64/188 (34%), Positives = 75/188 (39%), Gaps = 45/188 (23%)

Query: 547 EDAKKEMASLSAAAITVPPSVPSRAPVPPA-PPLPGDSGTIIPPPPAPGDSTTPPPP--- 602
           + +K  +A     A  V  + P+ +  PPA PP  G      PP   PG + TPPP    
Sbjct: 105 DSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSG-----APPGSGPGPTPTPPPAVTS 159

Query: 603 -PPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPE---GVGIPSPS 658
            PP  PPP P   GV     P+ P      PPPP    A +P P P P+   G G P   
Sbjct: 160 APPGAPPPTPPSSGV-----PTTPPQAGGPPPPP----AAVPGPGPGPKQGPGPGGPKGG 210

Query: 659 SLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGE--AGMPPPPP------- 709
            +PGG       P PG        P L    G P PP    GE   G    PP       
Sbjct: 211 KMPGG-------PKPGGG------PGLSTPGGHPKPPHRGGGEPRGGRQHHPPYHQQHHQ 257

Query: 710 -PLPGGPG 716
            P PGGPG
Sbjct: 258 GPPPGGPG 265


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.133    0.380 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,081,351
Number of Sequences: 37866
Number of extensions: 5258127
Number of successful extensions: 192269
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1768
Number of HSP's successfully gapped in prelim test: 2338
Number of HSP's that attempted gapping in prelim test: 33062
Number of HSP's gapped (non-prelim): 47118
length of query: 1263
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1149
effective length of database: 13,930,794
effective search space: 16006482306
effective search space used: 16006482306
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.