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Search of human proteins with 118498368
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|118498368 kinectin 1 isoform c [Homo sapiens]
(1300 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|118498368 kinectin 1 isoform c [Homo sapiens] 2474 0.0
gi|118498356 kinectin 1 isoform a [Homo sapiens] 2443 0.0
gi|33620775 kinectin 1 isoform a [Homo sapiens] 2443 0.0
gi|118498362 kinectin 1 isoform b [Homo sapiens] 2403 0.0
gi|110611218 ribosome binding protein 1 [Homo sapiens] 234 4e-61
gi|110611220 ribosome binding protein 1 [Homo sapiens] 234 4e-61
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 181 3e-45
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 179 2e-44
gi|71061468 centromere protein E [Homo sapiens] 179 2e-44
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 173 1e-42
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 171 3e-42
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 170 9e-42
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 167 8e-41
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 164 4e-40
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 164 7e-40
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 164 7e-40
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 163 9e-40
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 163 9e-40
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 160 1e-38
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 160 1e-38
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 160 1e-38
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 158 3e-38
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 157 5e-38
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 154 5e-37
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 153 1e-36
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 152 2e-36
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 152 2e-36
gi|21735548 centrosomal protein 2 [Homo sapiens] 151 4e-36
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 149 1e-35
gi|156104908 myosin heavy chain 6 [Homo sapiens] 149 1e-35
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 2474 bits (6411), Expect = 0.0
Identities = 1300/1300 (100%), Positives = 1300/1300 (100%)
Query: 1 MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK 60
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK
Sbjct: 1 MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK 60
Query: 61 KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK 120
KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK
Sbjct: 61 KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK 120
Query: 121 QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
Sbjct: 121 QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
Query: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA
Sbjct: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
Query: 241 DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE 300
DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE
Sbjct: 241 DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE 300
Query: 301 ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ 360
ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
Sbjct: 301 ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ 360
Query: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA
Sbjct: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
Query: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE
Sbjct: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
Query: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL 540
QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
Sbjct: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL 540
Query: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV
Sbjct: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
Query: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE
Sbjct: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
Query: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
Sbjct: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
Query: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ
Sbjct: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
Query: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA 840
DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA
Sbjct: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA 840
Query: 841 LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 900
LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL
Sbjct: 841 LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 900
Query: 901 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 960
QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT
Sbjct: 901 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 960
Query: 961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 1020
QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD
Sbjct: 961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 1020
Query: 1021 AVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGT 1080
AVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGT
Sbjct: 1021 AVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGT 1080
Query: 1081 SGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVD 1140
SGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVD
Sbjct: 1081 SGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVD 1140
Query: 1141 ESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRE 1200
ESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRE
Sbjct: 1141 ESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRE 1200
Query: 1201 LKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETE 1260
LKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETE
Sbjct: 1201 LKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETE 1260
Query: 1261 SSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
SSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE
Sbjct: 1261 SSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 2443 bits (6332), Expect = 0.0
Identities = 1300/1357 (95%), Positives = 1300/1357 (95%), Gaps = 57/1357 (4%)
Query: 1 MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK 60
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK
Sbjct: 1 MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK 60
Query: 61 KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK 120
KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK
Sbjct: 61 KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK 120
Query: 121 QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
Sbjct: 121 QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
Query: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA
Sbjct: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
Query: 241 DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE 300
DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE
Sbjct: 241 DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE 300
Query: 301 ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ 360
ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
Sbjct: 301 ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ 360
Query: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA
Sbjct: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
Query: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE
Sbjct: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
Query: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL 540
QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
Sbjct: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL 540
Query: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV
Sbjct: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
Query: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE
Sbjct: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
Query: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
Sbjct: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
Query: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ
Sbjct: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
Query: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA 840
DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA
Sbjct: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA 840
Query: 841 LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 900
LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL
Sbjct: 841 LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 900
Query: 901 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 960
QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT
Sbjct: 901 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 960
Query: 961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 1020
QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD
Sbjct: 961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 1020
Query: 1021 AVEHQRKKNN-----------------------------ERQQQVEAVELEAKEVLKKLF 1051
AVEHQRKKNN ERQQQVEAVELEAKEVLKKLF
Sbjct: 1021 AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLF 1080
Query: 1052 PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK 1111
PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK
Sbjct: 1081 PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK 1140
Query: 1112 SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE 1171
SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE
Sbjct: 1141 SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE 1200
Query: 1172 NLRREREHLEMELEKAEMERSTYVTEVRE----------------------------LKA 1203
NLRREREHLEMELEKAEMERSTYVTEVRE LKA
Sbjct: 1201 NLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKA 1260
Query: 1204 QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE 1263
QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE
Sbjct: 1261 QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE 1320
Query: 1264 KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE
Sbjct: 1321 KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1357
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 2443 bits (6332), Expect = 0.0
Identities = 1300/1357 (95%), Positives = 1300/1357 (95%), Gaps = 57/1357 (4%)
Query: 1 MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK 60
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK
Sbjct: 1 MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK 60
Query: 61 KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK 120
KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK
Sbjct: 61 KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK 120
Query: 121 QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
Sbjct: 121 QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
Query: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA
Sbjct: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
Query: 241 DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE 300
DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE
Sbjct: 241 DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE 300
Query: 301 ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ 360
ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
Sbjct: 301 ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ 360
Query: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA
Sbjct: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
Query: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE
Sbjct: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
Query: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL 540
QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
Sbjct: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL 540
Query: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV
Sbjct: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
Query: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE
Sbjct: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
Query: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
Sbjct: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
Query: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ
Sbjct: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
Query: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA 840
DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA
Sbjct: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA 840
Query: 841 LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 900
LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL
Sbjct: 841 LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 900
Query: 901 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 960
QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT
Sbjct: 901 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 960
Query: 961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 1020
QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD
Sbjct: 961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 1020
Query: 1021 AVEHQRKKNN-----------------------------ERQQQVEAVELEAKEVLKKLF 1051
AVEHQRKKNN ERQQQVEAVELEAKEVLKKLF
Sbjct: 1021 AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLF 1080
Query: 1052 PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK 1111
PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK
Sbjct: 1081 PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK 1140
Query: 1112 SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE 1171
SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE
Sbjct: 1141 SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE 1200
Query: 1172 NLRREREHLEMELEKAEMERSTYVTEVRE----------------------------LKA 1203
NLRREREHLEMELEKAEMERSTYVTEVRE LKA
Sbjct: 1201 NLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKA 1260
Query: 1204 QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE 1263
QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE
Sbjct: 1261 QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE 1320
Query: 1264 KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE
Sbjct: 1321 KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1357
>gi|118498362 kinectin 1 isoform b [Homo sapiens]
Length = 1306
Score = 2403 bits (6227), Expect = 0.0
Identities = 1277/1329 (96%), Positives = 1277/1329 (96%), Gaps = 52/1329 (3%)
Query: 1 MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK 60
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK
Sbjct: 1 MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK 60
Query: 61 KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK 120
KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK
Sbjct: 61 KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK 120
Query: 121 QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
Sbjct: 121 QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
Query: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA
Sbjct: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
Query: 241 DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE 300
DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE
Sbjct: 241 DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE 300
Query: 301 ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ 360
ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
Sbjct: 301 ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ 360
Query: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA
Sbjct: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
Query: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE
Sbjct: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
Query: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL 540
QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
Sbjct: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL 540
Query: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV
Sbjct: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
Query: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE
Sbjct: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
Query: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
Sbjct: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
Query: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ
Sbjct: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
Query: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA 840
DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTV
Sbjct: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTV--------- 831
Query: 841 LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 900
QLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL
Sbjct: 832 --------------QLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 877
Query: 901 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 960
QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT
Sbjct: 878 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 937
Query: 961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 1020
QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD
Sbjct: 938 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 997
Query: 1021 AVEHQRKKNN-----------------------------ERQQQVEAVELEAKEVLKKLF 1051
AVEHQRKKNN ERQQQVEAVELEAKEVLKKLF
Sbjct: 998 AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLF 1057
Query: 1052 PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK 1111
PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK
Sbjct: 1058 PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK 1117
Query: 1112 SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE 1171
SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE
Sbjct: 1118 SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE 1177
Query: 1172 NLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQ 1231
NLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQ
Sbjct: 1178 NLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQ 1237
Query: 1232 SLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTK 1291
SLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTK
Sbjct: 1238 SLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTK 1297
Query: 1292 EKEHYQVLE 1300
EKEHYQVLE
Sbjct: 1298 EKEHYQVLE 1306
>gi|110611218 ribosome binding protein 1 [Homo sapiens]
Length = 977
Score = 234 bits (597), Expect = 4e-61
Identities = 254/1071 (23%), Positives = 472/1071 (44%), Gaps = 180/1071 (16%)
Query: 21 IFLFFWLFMKETLYDEVLAKQKREQ-KLIPTKTDKKKAEK------KKNKKKEIQNGNLH 73
IFL MKET Y+E LA Q++E K K +KKK EK K KK+E NG +
Sbjct: 25 IFLVSTFSMKETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKI- 83
Query: 74 ESDSESVPR-DFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKE 132
D + P L + + VAP P+ Q P++
Sbjct: 84 -PDHDPAPNVTVLLREPVRAPAVAVAPTPV------------------QPPIIV------ 118
Query: 133 SDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQ---DKKVETLMVPSK 189
PV P P E AS K +KK K + + V ++ V +
Sbjct: 119 -------------APVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTS 165
Query: 190 RQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKR 249
+ L ET + G A S P K+
Sbjct: 166 KAAIL----ETAPKEGRNTDVAQS------------------------------PEAPKQ 191
Query: 250 EVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLK 309
E +KSG+KK + +K + ++ +M+F+E EA ++++L
Sbjct: 192 EA---------PAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILS 242
Query: 310 EKSGVIQDALKKSS-KGELTTLI-HQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKE 367
EK+G+IQD K++ KG+ ++ QL+EK+KLLA +EDAA K + ++L +EM EK
Sbjct: 243 EKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKA 302
Query: 368 RSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE----TQQMQMKFQQVREQME----AEI 419
++ ++K ++ E+E Q ++ SY+E QQ+Q K + ++EQ+E ++
Sbjct: 303 KAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQL 362
Query: 420 AHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNA 479
A L+QEN ILRDA++ T+Q+ESKQ+AEL KLRQ+ +++ EL EK+ ++Q+E Q+K
Sbjct: 363 ARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKAL 422
Query: 480 EQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKE-NEVQSLHSKLTD 538
E A + Q+ + + E + ++KR E V++E QS H+ L
Sbjct: 423 EAKAAAFEKQVLQLQASHRESEEALQKRLDE------------VSRELCHTQSSHASLRA 470
Query: 539 TLVSKQQLEQRLMQL---MESEQKRVNKE----ESLQMQVQDILEQNEALKAQIQQFHSQ 591
Q+ +Q++ +L ++S + V + L Q+Q+ +N L +I+ +
Sbjct: 471 DAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEAL 530
Query: 592 IAAQTSASVLAEELHKVIAEKDKQ---IKQTEDSLAS-ERDRLTSKEEELKDIQNMNFLL 647
+ A + A+++ AE D+Q +K+ E ++ E++ + +E + N L
Sbjct: 531 LEAGQARD--AQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLR 588
Query: 648 KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQN 707
+ + ++ALA + A +L + Q+ + ++ L+E Q + + E +L QN
Sbjct: 589 EKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQN 648
Query: 708 --KALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEEL 765
+ L+ +K TL+ P + + KL+ EE T + + ++
Sbjct: 649 YTEWLQDLKEKGPTLLKHPP------APAEPSSDLASKLREAEETQST----LQAECDQY 698
Query: 766 NAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVA 825
+I E + +++Q VEE ++V K G + EE L+ + V
Sbjct: 699 RSILAETEGMLRDLQ-------------KSVEEEEQVWRAKVG---AAEEELQKSRVTVK 742
Query: 826 NKEKTVQDLKQEIKA---LKEEIGNVQLEKAQQLSITS--------KVQELQNLLKGKEE 874
+ E+ V+ LK E+++ ++E +++ E + ++ S +V L+ LL +
Sbjct: 743 HLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQS 802
Query: 875 QMNTMKAVLEEKEKDLANTGKWLQDLQEENE-----SLKAHVQEVAQHNLKEASSASQFE 929
Q++ K+ +++ +LA + L +++ E A E +Q E
Sbjct: 803 QLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLE 862
Query: 930 ELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQAS 989
E +L++++ + ++L A +E ++ + L+ ++ L S+ E+ Q +
Sbjct: 863 WTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERL-- 920
Query: 990 SFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVE 1040
E+ K+ S+ + + L L + ++ + ++ + Q+Q+E E
Sbjct: 921 -----EKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAE 966
Score = 189 bits (479), Expect = 2e-47
Identities = 180/717 (25%), Positives = 331/717 (46%), Gaps = 85/717 (11%)
Query: 602 AEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQ 661
A+ L ++++EK I+ T + D + + +L+ E +KL A E
Sbjct: 234 AQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLE-----------EKEKLLATEQED 282
Query: 662 AAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLV 721
AA A K+R L +++ E + + Q A + E+ +Q +
Sbjct: 283 AAVAKS-------------KLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARM 329
Query: 722 SEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGL-IQVATKEEELNAIRTENSSLTKEVQ 780
+ V E +Q+ K++T++E LE G Q+A ++E + +R + T +V+
Sbjct: 330 QASYREHVKE-----VQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVE 384
Query: 781 DLKAKQNDQVSFASLVEELKKV---IHEKDGKIKSVEELLEAELLKVANKEKTV------ 831
+KQN ++ A L +EL KV + EK ++ E+ +A K A EK V
Sbjct: 385 ---SKQNAEL--AKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQAS 439
Query: 832 -----QDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEK 886
+ L++ + + E+ + Q A + K QE Q + ++ + +A + K
Sbjct: 440 HRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSK 499
Query: 887 EKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLE 946
++L+ LQ+ + EN L ++ + L EA A ++++ E + + RL
Sbjct: 500 CEELSGLHGQLQEARAENSQLTERIRSIEA--LLEAGQARDAQDVQASQAEADQQQTRL- 556
Query: 947 AMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREK 1006
KE ES +S + ++++ + K + L+++N++ + E+ K
Sbjct: 557 ---KELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACK------- 606
Query: 1007 EISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWL 1066
+L SL A E E ++Q+ +E + E L L P++SV + +Y EWL
Sbjct: 607 ------EKLHSLTQAKE-------ESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWL 653
Query: 1067 HGFEKKAKECMAGTSG-SEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQ 1125
++K + +E L KL+EA+E + LQ EC++Y+S+LAETEG+L+ LQ
Sbjct: 654 QDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQ 713
Query: 1126 RSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELE 1185
+SVE+EE W+ KV + + +++ + + E+ +E+L+ E + + +R HLE ELE
Sbjct: 714 KSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELE 773
Query: 1186 K----AEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIV 1241
K A E Y EV L+ L E+ ++L ++E QK + +L +Q L ++S +
Sbjct: 774 KHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHV- 832
Query: 1242 KAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQ-LQQLLQAVNQQLTKEKEHYQ 1297
D + SPE +E++ + + T+ + + Q Q+LT E E Q
Sbjct: 833 ---EDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQ 886
>gi|110611220 ribosome binding protein 1 [Homo sapiens]
Length = 977
Score = 234 bits (597), Expect = 4e-61
Identities = 254/1071 (23%), Positives = 472/1071 (44%), Gaps = 180/1071 (16%)
Query: 21 IFLFFWLFMKETLYDEVLAKQKREQ-KLIPTKTDKKKAEK------KKNKKKEIQNGNLH 73
IFL MKET Y+E LA Q++E K K +KKK EK K KK+E NG +
Sbjct: 25 IFLVSTFSMKETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKI- 83
Query: 74 ESDSESVPR-DFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKE 132
D + P L + + VAP P+ Q P++
Sbjct: 84 -PDHDPAPNVTVLLREPVRAPAVAVAPTPV------------------QPPIIV------ 118
Query: 133 SDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQ---DKKVETLMVPSK 189
PV P P E AS K +KK K + + V ++ V +
Sbjct: 119 -------------APVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTS 165
Query: 190 RQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKR 249
+ L ET + G A S P K+
Sbjct: 166 KAAIL----ETAPKEGRNTDVAQS------------------------------PEAPKQ 191
Query: 250 EVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLK 309
E +KSG+KK + +K + ++ +M+F+E EA ++++L
Sbjct: 192 EA---------PAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILS 242
Query: 310 EKSGVIQDALKKSS-KGELTTLI-HQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKE 367
EK+G+IQD K++ KG+ ++ QL+EK+KLLA +EDAA K + ++L +EM EK
Sbjct: 243 EKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKA 302
Query: 368 RSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE----TQQMQMKFQQVREQME----AEI 419
++ ++K ++ E+E Q ++ SY+E QQ+Q K + ++EQ+E ++
Sbjct: 303 KAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQL 362
Query: 420 AHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNA 479
A L+QEN ILRDA++ T+Q+ESKQ+AEL KLRQ+ +++ EL EK+ ++Q+E Q+K
Sbjct: 363 ARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKAL 422
Query: 480 EQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKE-NEVQSLHSKLTD 538
E A + Q+ + + E + ++KR E V++E QS H+ L
Sbjct: 423 EAKAAAFEKQVLQLQASHRESEEALQKRLDE------------VSRELCHTQSSHASLRA 470
Query: 539 TLVSKQQLEQRLMQL---MESEQKRVNKE----ESLQMQVQDILEQNEALKAQIQQFHSQ 591
Q+ +Q++ +L ++S + V + L Q+Q+ +N L +I+ +
Sbjct: 471 DAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEAL 530
Query: 592 IAAQTSASVLAEELHKVIAEKDKQ---IKQTEDSLAS-ERDRLTSKEEELKDIQNMNFLL 647
+ A + A+++ AE D+Q +K+ E ++ E++ + +E + N L
Sbjct: 531 LEAGQARD--AQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLR 588
Query: 648 KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQN 707
+ + ++ALA + A +L + Q+ + ++ L+E Q + + E +L QN
Sbjct: 589 EKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQN 648
Query: 708 --KALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEEL 765
+ L+ +K TL+ P + + KL+ EE T + + ++
Sbjct: 649 YTEWLQDLKEKGPTLLKHPP------APAEPSSDLASKLREAEETQST----LQAECDQY 698
Query: 766 NAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVA 825
+I E + +++Q VEE ++V K G + EE L+ + V
Sbjct: 699 RSILAETEGMLRDLQ-------------KSVEEEEQVWRAKVG---AAEEELQKSRVTVK 742
Query: 826 NKEKTVQDLKQEIKA---LKEEIGNVQLEKAQQLSITS--------KVQELQNLLKGKEE 874
+ E+ V+ LK E+++ ++E +++ E + ++ S +V L+ LL +
Sbjct: 743 HLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQS 802
Query: 875 QMNTMKAVLEEKEKDLANTGKWLQDLQEENE-----SLKAHVQEVAQHNLKEASSASQFE 929
Q++ K+ +++ +LA + L +++ E A E +Q E
Sbjct: 803 QLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLE 862
Query: 930 ELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQAS 989
E +L++++ + ++L A +E ++ + L+ ++ L S+ E+ Q +
Sbjct: 863 WTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERL-- 920
Query: 990 SFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVE 1040
E+ K+ S+ + + L L + ++ + ++ + Q+Q+E E
Sbjct: 921 -----EKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAE 966
Score = 189 bits (479), Expect = 2e-47
Identities = 180/717 (25%), Positives = 331/717 (46%), Gaps = 85/717 (11%)
Query: 602 AEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQ 661
A+ L ++++EK I+ T + D + + +L+ E +KL A E
Sbjct: 234 AQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLE-----------EKEKLLATEQED 282
Query: 662 AAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLV 721
AA A K+R L +++ E + + Q A + E+ +Q +
Sbjct: 283 AAVAKS-------------KLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARM 329
Query: 722 SEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGL-IQVATKEEELNAIRTENSSLTKEVQ 780
+ V E +Q+ K++T++E LE G Q+A ++E + +R + T +V+
Sbjct: 330 QASYREHVKE-----VQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVE 384
Query: 781 DLKAKQNDQVSFASLVEELKKV---IHEKDGKIKSVEELLEAELLKVANKEKTV------ 831
+KQN ++ A L +EL KV + EK ++ E+ +A K A EK V
Sbjct: 385 ---SKQNAEL--AKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQAS 439
Query: 832 -----QDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEK 886
+ L++ + + E+ + Q A + K QE Q + ++ + +A + K
Sbjct: 440 HRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSK 499
Query: 887 EKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLE 946
++L+ LQ+ + EN L ++ + L EA A ++++ E + + RL
Sbjct: 500 CEELSGLHGQLQEARAENSQLTERIRSIEA--LLEAGQARDAQDVQASQAEADQQQTRL- 556
Query: 947 AMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREK 1006
KE ES +S + ++++ + K + L+++N++ + E+ K
Sbjct: 557 ---KELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACK------- 606
Query: 1007 EISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWL 1066
+L SL A E E ++Q+ +E + E L L P++SV + +Y EWL
Sbjct: 607 ------EKLHSLTQAKE-------ESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWL 653
Query: 1067 HGFEKKAKECMAGTSG-SEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQ 1125
++K + +E L KL+EA+E + LQ EC++Y+S+LAETEG+L+ LQ
Sbjct: 654 QDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQ 713
Query: 1126 RSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELE 1185
+SVE+EE W+ KV + + +++ + + E+ +E+L+ E + + +R HLE ELE
Sbjct: 714 KSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELE 773
Query: 1186 K----AEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIV 1241
K A E Y EV L+ L E+ ++L ++E QK + +L +Q L ++S +
Sbjct: 774 KHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHV- 832
Query: 1242 KAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQ-LQQLLQAVNQQLTKEKEHYQ 1297
D + SPE +E++ + + T+ + + Q Q+LT E E Q
Sbjct: 833 ---EDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQ 886
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 181 bits (460), Expect = 3e-45
Identities = 217/1077 (20%), Positives = 466/1077 (43%), Gaps = 100/1077 (9%)
Query: 300 EALCVVDL---LKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCK 356
EA + DL L ++ G+ A+ K ++ TL+ D + + ++ KD CK
Sbjct: 203 EATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLM------DNMTLERERESEKLKDECK 256
Query: 357 QLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQME 416
+L + + S I++++ + +E V+ ++ ++ K Q + E +
Sbjct: 257 KLQSQYAS----SEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENL- 311
Query: 417 AEIAHLKQENGILRDAVSNTTNQLESKQ-SAELNKLRQDYARLVNELTEKTGKLQQEEVQ 475
LK+E + + + K A L++ D +L + L+ L + V+
Sbjct: 312 -----LKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVE 366
Query: 476 KKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQ----------DLQSKFVAK 525
+A +LK +L E E +++ +++ ++ + E +Q L SK +
Sbjct: 367 LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLET 426
Query: 526 ENEVQSLHSKLTDTL-VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQ 584
E ++ H +L + +S ++L + Q+ + + K EE L+ +V + E L
Sbjct: 427 ERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKT 486
Query: 585 IQQFHSQIAAQTSASVLA-------EELHKVIAEKDKQIKQTEDSLASERDRLTSKEEEL 637
QQ Q A Q S + E++ + I +KD++I+ E L ++ ++ E+E
Sbjct: 487 KQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKER 546
Query: 638 KDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKM 697
+D+ + E L L + ++ ++ + + + + + +E L ++ +
Sbjct: 547 EDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQK 606
Query: 698 EEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEEL------- 750
+ D+ +L++ V +L + ++E +K+ V Q++ I+ K E L + E
Sbjct: 607 AHLRAAQDRVLSLETSVNELNSQLNE--SKEKVSQLDIQIKAKTELLLSAEAAKTAQRAD 664
Query: 751 ----LETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEK 806
L+T + K++ELN I T+ +T ++QD + + S +E + +K
Sbjct: 665 LQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQK 724
Query: 807 DGKIKSVEELLEAELLKV-ANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQEL 865
+++ + LEA+ L+V A+KE+ +QDL+Q+ + L ++ E ++QL + ++
Sbjct: 725 TEELEGQIKKLEADSLEVKASKEQALQDLQQQ-RQLNTDLELRATELSKQLEMEKEIVSS 783
Query: 866 QNL-LKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASS 924
L L+ K E + ++K L ++E++ + + L +E + + Q + E
Sbjct: 784 TRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQK 843
Query: 925 ASQFEE-LEIVLKEKENELKRLEAMLKERESDLSSKTQL--------------------- 962
+E L L +++L ++ LK +S+ + Q
Sbjct: 844 VKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV 903
Query: 963 -LQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELL----KVISEREKEISGLWNELDS 1017
+++ E K K +E+ K+ ++Q +E L + + EKE L ++
Sbjct: 904 QMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINE 963
Query: 1018 LKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGE------WLHGFEK 1071
LK + E ++K+ Q +++ L+ E+ KL +++ + E + +EK
Sbjct: 964 LKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEK 1023
Query: 1072 KA---KECMAGTSGSE-EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRS 1127
K+ + G E E+ LK +E +L Q + ++ + ++Q+L+ +
Sbjct: 1024 SQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTA 1083
Query: 1128 ---VEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENL--RRERE--HL 1180
+EQ+ K + ++ E K ++ +Q + E+EL +S+ +IE + R+E+E L
Sbjct: 1084 KATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKL 1143
Query: 1181 EMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKI 1240
EL+ ++E +T +++ K L + +L+ + + K A + K Q + Q K
Sbjct: 1144 NEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKA-DSLKAAVEQEKRNQQILKDQVKK 1202
Query: 1241 VKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1297
+ IE + +E EKE + +L + A+N+ L K+ +Q
Sbjct: 1203 EEEELKKEFIE-KEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQ 1258
Score = 179 bits (453), Expect = 2e-44
Identities = 232/1042 (22%), Positives = 446/1042 (42%), Gaps = 189/1042 (18%)
Query: 335 QEKDKLLAAVKEDAAATKDRCKQLT--QEMMTEKERSNVVITRMKDRIGTLEKEHNVFQN 392
QE L A++KE+ +++ K+L Q + ++ + + ++T + +LE++ Q
Sbjct: 90 QEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQT 149
Query: 393 KIHVSYQETQQMQMKFQQVREQMEAEIAHLKQ---ENGILRDAVSNTTNQLESKQSAELN 449
+ +QM+ F+Q Q+ EIA +K E LR+A +L + ELN
Sbjct: 150 ENF----NIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRL----TEELN 201
Query: 450 KLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTA 509
K L EL ++ G ++ V KK Q T + E ER E+++ +K +
Sbjct: 202 KEATVIQDLKTELLQRPG-IEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQS 260
Query: 510 EH---EAAQQDLQSKFVAKENEV-------QSLHSKLTDTLVSKQQLEQRLMQLMESEQK 559
++ EA L+S+ EV Q L S + + Q L + L++ + K
Sbjct: 261 QYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTK 320
Query: 560 ---RVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQI 616
+ N+E + +Q L Q + QQ S+++A ++ +H ++EK +
Sbjct: 321 LEEKHNEESVSKKNIQATLHQKDL---DCQQLQSRLSASETS---LHRIHVELSEKGEAT 374
Query: 617 KQTEDSLASERDRLTSKEEELKDIQNMN-------FLLKAEVQKLQA------------- 656
++ ++ L+ + + E K +Q L++E+ +L +
Sbjct: 375 QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAH 434
Query: 657 --LANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEV 714
L ++ ++ +L +Q V K+ LEEQL+ +++N E L D+ K E
Sbjct: 435 GRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQL-DKTKQQHQEQ 493
Query: 715 QKLQ--TLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEE-------- 764
Q LQ T + ++ +EQ+ + I +KD+K++ +E LL+ ++ E+E
Sbjct: 494 QALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKI 553
Query: 765 ---------LNAIRTENSSLTKEVQDLKAK-QNDQVSFASLVEELKKVIHEKDGKIKSVE 814
LN ++ +N +L ++V L K +N S E L + E+ +++ +
Sbjct: 554 QAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQ 613
Query: 815 ELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLE---------------KAQQLSIT 859
+ +V + E +V +L ++ KE++ + ++ AQ+ +
Sbjct: 614 D-------RVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQ 666
Query: 860 SKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNL 919
+ + QN L+ K++++N + L++ T K LQD QE L++H++E + L
Sbjct: 667 NHLDTAQNALQDKQQELNKITTQLDQV------TAK-LQDKQEHCSQLESHLKEYKEKYL 719
Query: 920 KEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQ 979
LE +E E ++K+LEA E ++ SK Q LQD+Q + +L + +E
Sbjct: 720 S----------LEQKTEELEGQIKKLEADSLEVKA---SKEQALQDLQQQRQL-NTDLEL 765
Query: 980 LKQQNYQQASSFPPHEELLKVISEREKEI-SGLWNELDSLKDAVEHQRKKNNERQQQVEA 1038
+ +Q E EKEI S +L +A+E ++K +++++
Sbjct: 766 RATELSKQL--------------EMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEE--- 808
Query: 1039 VELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADE 1098
K++LK+ F +S + + + E + + E ++VK+ KEA
Sbjct: 809 -----KQILKQDFETLSQETKIQHEELNNRIQTTVTEL-------QKVKME----KEA-- 850
Query: 1099 MHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQ 1158
L E K L++ L+ + E+E K K + + KT K+++
Sbjct: 851 ----LMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQL----- 901
Query: 1159 ELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNE 1218
+EN +E++ L+ LEK + E+ ++ QL + L+ + E
Sbjct: 902 --------QVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE 953
Query: 1219 RQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQL 1278
Q++ G++++ +QS E + +I G+ + V +TE K L
Sbjct: 954 EQQLQGNINELKQSSEQKKKQIEALQGELKIA----VLQKTELENK-------------L 996
Query: 1279 QQLLQAVNQQLTKEKEHYQVLE 1300
QQ L Q+L EKE VL+
Sbjct: 997 QQQLTQAAQELAAEKEKISVLQ 1018
Score = 166 bits (421), Expect = 1e-40
Identities = 262/1314 (19%), Positives = 562/1314 (42%), Gaps = 170/1314 (12%)
Query: 90 LAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVT 149
LA++ D V + V + +S++E K ++ K LE+ + +K G +
Sbjct: 78 LALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDS---- 133
Query: 150 KQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKK 209
+E + +++ + +++N + Q K + E + + +E +
Sbjct: 134 -----SAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREA 188
Query: 210 KASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLK-PDQVEGIQKSGT 268
+ TE + + +I L V K+E++ + D + ++ +
Sbjct: 189 AEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERES 248
Query: 269 KKLKTETDKENAEVKFKDFLLS-LKTMMFS--EDEALCVVDLLKEKSGVIQDALKKSSKG 325
+KLK E K ++ + +S L++ + ++ A+ V +L K KS V + K +
Sbjct: 249 EKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLT 308
Query: 326 ELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEK 385
E L+ + Q+ KL E++ + K+ L Q+ ++ +++ R+ E
Sbjct: 309 E--NLLKKEQDYTKLEEKHNEESVSKKNIQATLHQK--------DLDCQQLQSRLSASET 358
Query: 386 EHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDA----------VSN 435
++IHV E + K ++ ++E + HLK E L+ + +
Sbjct: 359 S----LHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQS 414
Query: 436 TTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAER 495
NQL SK +L + + RL + + KL +E Q + + ++L+ QL+E
Sbjct: 415 EINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVT 474
Query: 496 RWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLME 555
E+Q + K +H+ QQ LQ AK E Q+ ++ + K Q Q L L++
Sbjct: 475 NSTELQHQLDKTKQQHQE-QQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQ 533
Query: 556 SEQKRVN----KEESLQMQVQ----------DILEQNEALKAQIQQFHSQIAAQTSASVL 601
++ ++ + E L ++Q + E+N L+ Q+ Q ++ Q+ +
Sbjct: 534 KSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQ 593
Query: 602 AEE-LHKVIAEKDKQIKQTED---SLASERDRLTSKEEELKD-IQNMNFLLKAEVQKL-- 654
A+E LH + E+ ++ +D SL + + L S+ E K+ + ++ +KA+ + L
Sbjct: 594 AQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLS 653
Query: 655 --QALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH-------------EISNKMEE 699
A ++A + L+ Q ++ K ++ + QL ++ + ++E
Sbjct: 654 AEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKE 713
Query: 700 FK----ILNDQNKALKSEVQKLQT------LVSEQPNKDVVEQ------MEKCIQEKDEK 743
+K L + + L+ +++KL+ EQ +D+ +Q +E E ++
Sbjct: 714 YKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQ 773
Query: 744 LKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK----------QNDQVS-- 791
L+ +E++ + + + K E L +I+ + + +E Q LK Q+++++
Sbjct: 774 LEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNR 833
Query: 792 FASLVEELKKVIHEKDG----------KIKSVEELLE---AELLKVANKEKT-VQDLKQE 837
+ V EL+KV EK+ K+ V + L+ +E K K K + DL++
Sbjct: 834 IQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKT 893
Query: 838 IKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWL 897
K LK ++ VQ+E + + +EL+ L+ ++E + +K L ++ L L
Sbjct: 894 CKELKHQL-QVQMENTLK-----EQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTL 947
Query: 898 QDLQEENESLKAHVQEVAQHNLKEASSASQFE-ELEIVLKEKENELKRLEAMLKERESDL 956
+ ++E + L+ ++ E+ Q + ++ + EL+I + +K +L+ L + +L
Sbjct: 948 KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQEL 1007
Query: 957 SSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISER-----EKEISG- 1010
+++ + + +Q+ + + +QL+ Y + S + LK + E+ E IS
Sbjct: 1008 AAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNR 1067
Query: 1011 --------LWNELDSLKDAVEHQR-KKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLS 1061
L EL + K +E KK + Q++ +A++ KE K V+ S L+
Sbjct: 1068 NQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLA 1127
Query: 1062 YGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGIL 1121
E E K ++ T +EE+K HKL+ E+ L + + L E +G
Sbjct: 1128 EIE-----EIKCRQEKEITKLNEELK--SHKLESIKEITNLKDAKQLLIQQKL-ELQGKA 1179
Query: 1122 QKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLE 1181
L+ +VEQE+ ++ D+ K ++++ F E +L SE K+ E ++ E E
Sbjct: 1180 DSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEA---KLHSEIKEKEVGMKKHEENE 1236
Query: 1182 MEL------------------EKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVA 1223
+L + ++ S + +L+ ++ ++ Q+ER+ +
Sbjct: 1237 AKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALL 1296
Query: 1224 GDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQ 1277
K + +E +Q+K+++ ++N+ + + E +++ + Q + +
Sbjct: 1297 ERCLKGEGEIEKLQTKVLEL---QRKLDNTTAAVQELGRENQSLQIKHTQALNR 1347
Score = 158 bits (399), Expect = 4e-38
Identities = 272/1236 (22%), Positives = 512/1236 (41%), Gaps = 151/1236 (12%)
Query: 36 EVLAKQKREQKLIPTKTDKKKAEKKKNKKK-EIQNGNLHESDSESVPRDFKLSDALAVED 94
E +A K+E + T D E+++ +K + + L + S +L LA
Sbjct: 221 EDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGP 280
Query: 95 DQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTP 154
+VA + + SSV E +K + + E + KE D +K+ K
Sbjct: 281 QEVAVYVQELQKLKSSVNELTQKNQT---LTENLLKKEQDYTKLEEKH------------ 325
Query: 155 PSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSK 214
+E + SKK + D Q ++++ + S+ LH+ + S G+ K
Sbjct: 326 -NEESVSKKNIQATLHQKDLDCQ--QLQSRLSASETS----LHRIHVELSEKGEATQKLK 378
Query: 215 KQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTE 274
++ +E V+ H A+ + +RE + I + +K L+TE
Sbjct: 379 EELSE---VETKYQHL--------KAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETE 427
Query: 275 TDKENAEVKFKDFL-LSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQ 333
A + K+ LS + +M E + V DL + S + + +K + T L HQ
Sbjct: 428 RQLGEAHGRLKEQRQLSSEKLMDKEQQ---VADLQLKLSRLEEQLKEKVTNS--TELQHQ 482
Query: 334 L-------QEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSN---VVITRMKDRIGTL 383
L QE+ L + ++ +Q+ +++ + ++ ++ + K+ I L
Sbjct: 483 LDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLL 542
Query: 384 EKEHNVFQNKIHVSYQET---QQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQL 440
EKE KI ET Q+Q K ++EQ+ LK ++ + A N +Q+
Sbjct: 543 EKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQV 602
Query: 441 ESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQ---LQEAERRW 497
+ +Q A L + L + E +L + K+ Q Q+K + L AE
Sbjct: 603 Q-EQKAHLRAAQDRVLSLETSVNELNSQLNES---KEKVSQLDIQIKAKTELLLSAEAAK 658
Query: 498 EEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESE 557
++ ++ + A QD Q + ++ + +KL D QLE L + E
Sbjct: 659 TAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKY 718
Query: 558 QKRVNKEESLQMQVQ----DILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKD 613
K E L+ Q++ D LE + + +Q Q T + A EL K + +
Sbjct: 719 LSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEK 778
Query: 614 KQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQ 673
+ + T L + + L S +++L + +LK Q + L+ E EL Q
Sbjct: 779 EIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILK---QDFETLSQETKIQHEELNNRIQ 835
Query: 674 SVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQM 733
+ + K+++ +E L E+S ++ ++D K KSE +K Q K + +
Sbjct: 836 TTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEK-----ENQKGKAAILDL 890
Query: 734 EKCIQEKDEKLK-----TVEELLETGLIQVATKEEELN-AIRTENSSLTKEV----QDLK 783
EK +E +L+ T++E E L + KE+E + ++ E +S+ +++ LK
Sbjct: 891 EKTCKELKHQLQVQMENTLKEQKE--LKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLK 948
Query: 784 AKQNDQVSFASLVEELKKVIHEKDGKIKSVE-ELLEAELLKVANKEKTVQDLKQ---EIK 839
+ ++ + ELK+ +K +I++++ EL A L K + K Q L Q E+
Sbjct: 949 QNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELA 1008
Query: 840 ALKEEIGNVQ--LEKAQQL---------SITSKVQELQNLLKGKEEQMNTMKAVLEEKEK 888
A KE+I +Q EK+Q+ S++ + LK EE+++ + L
Sbjct: 1009 AEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRN 1068
Query: 889 DLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAM 948
+ N K +Q+L+ +L+ + Q L+E A Q + E LKEKE
Sbjct: 1069 QIGNQNKLIQELKTAKATLEQDSAKKEQQ-LQERCKALQDIQKEKSLKEKE--------- 1118
Query: 949 LKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEI 1008
L +S L+ ++ + E ++ K E+LK + ++ +++ +++ E+
Sbjct: 1119 LVNEKSKLAEIEEI--KCRQEKEITKLN-EELKSHKLESIKEITNLKDAKQLLIQQKLEL 1175
Query: 1009 SGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHG 1068
G + DSLK AVE +++ + QV+ E E LKK F
Sbjct: 1176 QG---KADSLKAAVEQEKRNQQILKDQVKKEE----EELKKEF----------------- 1211
Query: 1069 FEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSV 1128
EK+AK E+K E +K+ +E L ++ + L E G ++K +S
Sbjct: 1212 IEKEAKL-------HSEIKEKEVGMKKHEENEAKLTMQI----TALNENLGTVKKEWQSS 1260
Query: 1129 EQEENKWKVKVDESHKTIKQMQSSFTSSEQE----LERLRSENKDIENLRREREHLEMEL 1184
++ ++ + + D+ I ++++ +++ E LER +IE L+ + L+ +L
Sbjct: 1261 QRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKL 1320
Query: 1185 EKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQ 1220
+ E + L+ + + L + E NE Q
Sbjct: 1321 DNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQ 1356
Score = 114 bits (286), Expect = 5e-25
Identities = 170/844 (20%), Positives = 365/844 (43%), Gaps = 174/844 (20%)
Query: 620 EDSLASERDRLTSKEEELKDIQN-------MNFLLKAEVQKLQALANEQA---------- 662
E +LA +RD +T +E++D+Q + LK E++K Q L ++A
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 663 AAAHELEKMQQSVYVKDDKIRLLE---EQLQHEISNKMEEFKILNDQNKALKSEVQKLQT 719
A LE+ + ++ I+ ++ EQ +++ ++ + K D+ ++L+ ++ T
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194
Query: 720 LVSEQPNKD--------------------------------VVEQMEKCIQEKDEKLK-- 745
++E+ NK+ +++ M + + EKLK
Sbjct: 195 RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254
Query: 746 -------------TVEEL---LETGLIQVATKEEELNAIRTENSSLTKE----VQDLKAK 785
T+ +L L G +VA +EL +++ + LT++ ++L K
Sbjct: 255 CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKK 314
Query: 786 QNDQVSFASLVEE-------LKKVIHEKD-------GKIKSVEELLEAELLKVANKEKTV 831
+ D E ++ +H+KD ++ + E L ++++ K +
Sbjct: 315 EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEAT 374
Query: 832 QDLKQEI-------KALKEEIGNVQLEKAQQ----LSITSKVQELQNLLKGKEEQMNTMK 880
Q LK+E+ + LK E +Q ++ ++ L + S++ +L + L E Q+
Sbjct: 375 QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAH 434
Query: 881 AVLEE-----------KEKDLANTGKWLQDLQE------------ENESLKAHVQEVAQH 917
L+E KE+ +A+ L L+E +++ K Q Q
Sbjct: 435 GRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQ 494
Query: 918 NLKEASSASQFE---ELEIVLK---EKENELKRLEAMLKERESDLS-------------- 957
L+++++A E +LE VL+ +K+ +++ LEA+L++ + ++S
Sbjct: 495 ALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQ 554
Query: 958 ---SKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSF-PPHEELLKVISEREKEISGLWN 1013
+T +L +Q++N + Q+ QL ++ Q+ S E L + E++ + +
Sbjct: 555 AGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQD 614
Query: 1014 ELDSLKDAVEHQRKKNNERQQQVEAVELEAK---EVL-----KKLFPKVSVPSNLSYGEW 1065
+ SL+ +V + NE +++V ++++ K E+L K + + ++L +
Sbjct: 615 RVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQ- 673
Query: 1066 LHGFEKKAKECMAGTSGSEEVKV-LEHKLKEADEMHTLLQLECEKYKSV---LAETEGIL 1121
+ + K +E T+ ++V L+ K + ++ + L+ EKY S+ E EG +
Sbjct: 674 -NALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQI 732
Query: 1122 QKLQR-SVEQEENKWKVKVDESHK----TIKQMQSSFTSSEQELER--LRSENKDIENLR 1174
+KL+ S+E + +K + D + T +++++ S + E+E+ + S D++
Sbjct: 733 KKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKS 792
Query: 1175 REREHLEMELEKAEME----RSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQ 1230
E ++ +L K E E + + T +E K Q E +++T E QKV +
Sbjct: 793 EALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALM 852
Query: 1231 QSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLT 1290
L ++ K+ K + ++NS E E+ + + + L +T +L+ LQ +
Sbjct: 853 TELSTVKDKLSKVSDS---LKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTL 909
Query: 1291 KEKE 1294
KE++
Sbjct: 910 KEQK 913
Score = 90.5 bits (223), Expect = 9e-18
Identities = 127/629 (20%), Positives = 271/629 (43%), Gaps = 59/629 (9%)
Query: 703 LNDQNKALKSEVQKLQTL-VSEQPNKD--VVEQMEKCIQEKDEKLKTVEELLETGLIQVA 759
+ Q L S + T+ V+ + + + + Q K + DE K E + + G
Sbjct: 13 VGSQGSDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHYEAVHDAGNDSGH 72
Query: 760 TKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEA 819
E L R + + L +EVQDL+A ++ ++ EELKK + + G ++ E +
Sbjct: 73 GGESNLALKRDDVTLLRQEVQDLQASLKEEKWYS---EELKKELEKYQG-LQQQEAKPDG 128
Query: 820 ELLKVANKEKTVQDLKQEIKALKEEIGNVQL------EKAQQLS-----ITSKVQELQNL 868
V + +Q L+Q+++ + E N++ +KA QL+ I SK E ++L
Sbjct: 129 ---LVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSL 185
Query: 869 LKGKE-------EQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKE 921
+ E E++N V+++ + +L ++D+ + L VQ + + E
Sbjct: 186 REAAEQKVTRLTEELNKEATVIQDLKTELLQR-PGIEDVAVLKKEL-VQVQTLMDNMTLE 243
Query: 922 ASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLK 981
S E+L+ K+ +++ EA + + S+L+ Q + E + KS + +L
Sbjct: 244 RERES--EKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELT 301
Query: 982 QQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKN-NERQQQVEAVE 1040
Q+N + E+ + E+ E S + A HQ+ + + Q ++ A E
Sbjct: 302 QKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNI----QATLHQKDLDCQQLQSRLSASE 357
Query: 1041 LEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMH 1100
+ +L K L E L E K + A E K L+ + +E ++
Sbjct: 358 TSLHRIHVELSEKGEATQKLK--EELSEVETKYQHLKA------EFKQLQQQREEKEQHG 409
Query: 1101 TLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQEL 1160
LQ E + S L ETE L + ++++ K+ + + + +Q + E++L
Sbjct: 410 LQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQL 469
Query: 1161 ERLRSENKDIENL--RREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNE 1218
+ + + ++++ + +++H E + +++ST ++RE + L + L ++ + +
Sbjct: 470 KEKVTNSTELQHQLDKTKQQHQEQQ----ALQQST-TAKLREAQNDLEQVLRQIGDKDQK 524
Query: 1219 RQKVAGDLHKAQQSLELIQ-------SKIVKAAGDTTVIENSDVSPETESSEKETMSVSL 1271
Q + L K+++++ L++ +KI G+T V+ T + ++ L
Sbjct: 525 IQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKL 584
Query: 1272 NQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
+Q + ++ Q+ ++K H + +
Sbjct: 585 KNQSESHKQAQENLHDQVQEQKAHLRAAQ 613
Score = 63.9 bits (154), Expect = 9e-10
Identities = 119/654 (18%), Positives = 250/654 (38%), Gaps = 129/654 (19%)
Query: 51 KTDKKKAEKKKNKKKEIQN-GNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSS 109
K + E K +K++ +Q+ + +++ R +LS L +E + V+ L++ + S
Sbjct: 734 KLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSE 793
Query: 110 ---SVRERKKKEKKQKPVLEEQVIKESDASKIPGKKV----------------------- 143
S++++ K++++K +L++ S +KI +++
Sbjct: 794 ALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMT 853
Query: 144 EPVPVTKQPTPPSEAAASKKKPGQKKSKNGSD---DQDKKVETLMVPSKRQEALPLHQET 200
E V + + S++ + K +K+++ G D +K + L + Q L ++
Sbjct: 854 ELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQK 913
Query: 201 KQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSS----------------- 243
+ + K+K +S + K E + E LI A + + +
Sbjct: 914 ELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKK 973
Query: 244 -----------PVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLK 292
V+ K E+ + L+ + Q+ +K K + N E + F
Sbjct: 974 QIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQS 1033
Query: 293 TMMFSEDEALCVVDLLK---EKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAA 349
E E L LK EK + Q+ L S++ ++ +QE A +++D+A
Sbjct: 1034 DFYGRESELLATRQDLKSVEEKLSLAQEDLI-SNRNQIGNQNKLIQELKTAKATLEQDSA 1092
Query: 350 ATK----DRCKQLTQEMMTEKERSNVVITRMKDRIGTLE-----------------KEHN 388
+ +RCK L Q++ EK + K ++ +E K H
Sbjct: 1093 KKEQQLQERCKAL-QDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHK 1151
Query: 389 VFQNKIHVSYQETQQM----QMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQ 444
+ K + ++ +Q+ +++ Q + ++A + K+ IL+D V K+
Sbjct: 1152 LESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVK--------KE 1203
Query: 445 SAELNK-LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSY 503
EL K + A+L +E+ EK +++ E + T L L ++ W+ Q
Sbjct: 1204 EEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQ-- 1261
Query: 504 IRKRTAEHEAAQQDLQSKFVAKENEVQS----------------------------LHSK 535
+R +E E DL+ + E VQ+ L K
Sbjct: 1262 --RRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRK 1319
Query: 536 LTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFH 589
L +T + Q+L + L + +N++ + +VQ+ + + +++ H
Sbjct: 1320 LDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVRRHH 1373
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 179 bits (453), Expect = 2e-44
Identities = 313/1468 (21%), Positives = 635/1468 (43%), Gaps = 240/1468 (16%)
Query: 31 ETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDAL 90
ETL E L K ++Q ++ K + E +K + +E+++ + E + + + DAL
Sbjct: 23 ETLPKEDLIKFAKKQMMLIQKAKSRCTELEK-EIEELRSKPVTEGTGDIIKALTERLDAL 81
Query: 91 AVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASK------------I 138
+E ET KK+ K K +E+ V K DA K I
Sbjct: 82 LLEK----------AETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEI 131
Query: 139 PGKKVEPVPVTKQPTPPSEAAASKKKP------------GQKKSKNGSDDQDKKVETLMV 186
K E + V + SE A+ +K Q K +N S+D KK++ +
Sbjct: 132 ENLKNELMAVRSKY---SEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIE 188
Query: 187 ---PSKRQEALPLHQETKQESGSGKKKA----------SSKKQKTENVFVDEPL----IH 229
P ++ L L ++ + K+ S QK N +E L IH
Sbjct: 189 KIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIH 248
Query: 230 ATTYIPLMDNADSSPVVDKREVIDL--LKPDQVEGIQKSGTKKLKTETDKENAEVKFKDF 287
LM ++S + E+ L LK + V+ + E ++N + K++
Sbjct: 249 QEEVKELMCQIEASAKEHEAEINKLNELKENLVK----------QCEASEKNIQKKYECE 298
Query: 288 LLSLK--TMMFSEDEALC---------VVDLLKEKSGVIQDALKKSS------KGELTTL 330
L +L+ T ++D +C V ++ EK ++D LK+ K E+T +
Sbjct: 299 LENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYM 358
Query: 331 IHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVF 390
+ + + +K++ ++ + E++ KE VI ++K + L K+ F
Sbjct: 359 NNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQ---F 415
Query: 391 QNKIHVSYQETQQMQMKFQ-QVREQMEAEIAHLKQENGILRDAVSNTTNQLES----KQS 445
+ +E Q ++ + Q ++ E E ++ ++E L + Q E+ KQ
Sbjct: 416 CYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQE 475
Query: 446 AELN--KLRQDYARLVNELTEKTGKLQQE-EVQKKNAEQAATQLKVQLQEAERRWEEVQS 502
A LN LR+ L EL E GK+ QE E K+ +L+ +L+ A + +
Sbjct: 476 AILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLE 535
Query: 503 YIRKRTAEHEA--AQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQL------- 553
+ + E+E +QQ+L + EN +++L K L+S Q + L +L
Sbjct: 536 TVNRLQGENEKLLSQQELVPEL---ENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSL 592
Query: 554 -----------------MESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQT 596
M++ K+ +EE L +++ +EQ ++++Q +++
Sbjct: 593 TEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGL 652
Query: 597 SASVLAEELH-----------KVIAEKDKQIKQTEDSLASERDRLTSKEEEL-KDI---- 640
++ ++ + KV++E + + SL E ++L+S++++L +D+
Sbjct: 653 EETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFL 712
Query: 641 -QNMNFLLKAEV----QKLQALANEQAAAAHELEKMQ-QSVYVKDDKIRLLEEQLQHEIS 694
Q + +LK + +KLQ + EQ LE Q Q ++VK L+E + E+S
Sbjct: 713 SQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKE-MGSEVS 771
Query: 695 NKMEEFKILNDQNKALKS--EVQKLQTLVSEQPNKDVVEQME--KCIQEKDE-KLKTVEE 749
EE ++N +S ++ + + ++ Q ++ V+E + KC+QE+ + + ++
Sbjct: 772 EDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKS 831
Query: 750 LLETGLIQVATKEEELNAIRTENSSLTKEVQDLK-AKQNDQVSFASLVEELKKVIHE-KD 807
LL + +EL I++E +L ++ ++K A + ++ +L+ ++++V
Sbjct: 832 LLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSK 891
Query: 808 GKIKSVEE---LLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLS----ITS 860
+I + +E + E E LK ++K ++D + E+ LK+ + K LS +
Sbjct: 892 SEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEE 951
Query: 861 KVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLK 920
K++ L+ K KEE++N +K V + +K+L ++ K Q ++EE ESL++ +++
Sbjct: 952 KIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRD 1011
Query: 921 EASSASQFEELEIVLKEKENEL-------KRLEAMLKERESDLSSKTQLLQDVQDENKLF 973
A ++ L + +++ +L E +++ L + T + + +N+
Sbjct: 1012 LIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDL 1071
Query: 974 KSQIEQLKQQ---------NYQQASSFPPHE-ELLKVISERE-KEISGLWNELDSLKDAV 1022
++IE L+ Q+A + E E K+ E++ KE + NEL+ L+ +
Sbjct: 1072 LARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQL 1131
Query: 1023 EHQRKKNNERQQQVEAVELEAKE-------------VLKKLFPKVSVPSN-LSYGEWLHG 1068
+ ++K+ + Q++E V+ +A++ ++K+L K++ +N + E
Sbjct: 1132 QKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIK 1191
Query: 1069 FEKKAKECMAGTSGSEEVKVLEHKLKEADEMHT-----LLQLECEKYKSVLAETEGILQK 1123
+K+ +E + EE+ L+ +++ +E +T L++ + E S AET+ ++ +
Sbjct: 1192 IQKQKQETL-----QEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQ 1246
Query: 1124 LQRSVEQEENKWKVKV---------DESHKTIKQMQSSFTSSEQELERLRSENKDIENLR 1174
E E ++ +V+V E HK + ++ TS+EQ L + + + L+
Sbjct: 1247 ASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLK---TSAEQHQRTLSAYQQRVTALQ 1303
Query: 1175 REREHLEMELEKAEMERSTYVTEVRE-LKAQLNETLTKLRTE--QNERQ-------KVAG 1224
E + E E +Y V LK Q N+++++ TE + ER+ ++
Sbjct: 1304 EECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKI 1363
Query: 1225 DLHKAQQSLELIQSKI--VKAAGDTTVIENSDVSPETESSEKE-------------TMSV 1269
L +Q +L++ S++ +++ DT + ++ + ET S E E M
Sbjct: 1364 KLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKS 1423
Query: 1270 SLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1297
QTV+QL + + + H Q
Sbjct: 1424 EHTQTVSQLTSQNEVLRNSFRDQVRHLQ 1451
Score = 94.0 bits (232), Expect = 8e-19
Identities = 163/887 (18%), Positives = 377/887 (42%), Gaps = 96/887 (10%)
Query: 54 KKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRE 113
+K+ E+ +++K+ +Q+ L ++ R + + VE+ V +T S
Sbjct: 844 RKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEE---------VSQTCSKSEI 894
Query: 114 RKKKEK-------KQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPG 166
+KEK KP+LE++ +++ A I K + K P+ ++ +S K+
Sbjct: 895 HNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKD----SLAKSPSVKNDPLSSVKELE 950
Query: 167 QKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEP 226
+K + ++K+ K + + + K+E S +K+ + K++ E++ ++
Sbjct: 951 EKIENLEKECKEKE-------EKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKD 1003
Query: 227 LIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKD 286
+ A+ L+ A+S K +++ K + ++K + E+ + ++
Sbjct: 1004 QLSASMR-DLIQGAESY----KNLLLEYEKQSEQLDVEKERANNFEHRI--EDLTRQLRN 1056
Query: 287 FLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVK- 345
L +T+ ++ L ++ L+ + +++ + + + + ++ + E +KL K
Sbjct: 1057 STLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAK--AMVDKELEAEKLQKEQKI 1114
Query: 346 EDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE----- 400
++ A T + ++L ++ +KE+ + T + + + + N Y+
Sbjct: 1115 KEHATTVNELEEL--QVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKEL 1172
Query: 401 TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVN 460
Q++ K ++ E +E EI KQ+ L++ +++ + ++ + K++Q +
Sbjct: 1173 NQKLTNKNNKI-EDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKN-TKIKQLLVKTKK 1230
Query: 461 ELTE----KTGKLQQEEVQKKNAEQAATQL---KVQLQEAERRWEEVQSYIRKRTAEHEA 513
EL + +T L + K E + Q+ K+QL E ++ +++ +H+
Sbjct: 1231 ELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQR 1290
Query: 514 AQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQD 573
Q + A + E ++ ++ + + R+ +++ ++ NK S Q + +
Sbjct: 1291 TLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQK---NKSMS-QAETEG 1346
Query: 574 ILEQNEALKAQIQQFHSQIA-AQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTS 632
++ E L+ I Q ++ +Q + + EL + +E D +++ L +
Sbjct: 1347 AKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAE 1406
Query: 633 KEEELKDIQNMNFLLKAE-VQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH 691
E+L IQ+ N ++K+E Q + L ++ + D++R L+E+ +
Sbjct: 1407 LREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFR----------DQVRHLQEEHRK 1456
Query: 692 EISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELL 751
+ ++ + Q LK+E + S+Q K++ E+ + D T EE
Sbjct: 1457 TVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREE-- 1514
Query: 752 ETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIK 811
G T E +++ T SL + + + K + A +E +++ + K
Sbjct: 1515 --GEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKE--ELVQKLSSTTK 1570
Query: 812 SVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLL-- 869
S + L LL+ E T L ++IK LK EI ++ + ++ S + ++ L+N+L
Sbjct: 1571 SADHL--NGLLR--ETEATNAILMEQIKLLKSEIRRLERNQEREKS-AANLEYLKNVLLQ 1625
Query: 870 -----KGKEEQ-----MNTMKAVLEEKEKDLANTGKWLQDLQEENES 906
G E + +NTM + E++ LA + +EEN S
Sbjct: 1626 FIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQG----EEENAS 1668
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 179 bits (453), Expect = 2e-44
Identities = 266/1218 (21%), Positives = 534/1218 (43%), Gaps = 165/1218 (13%)
Query: 182 ETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATT--YIPLMDN 239
ET+ + +KR+ A L E + K+ A++ KQ ++ + + + A + L
Sbjct: 631 ETVALDAKRESAF-LRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKE 689
Query: 240 ADSS--------PVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSL 291
S+ ++D + DLL ++EG K+L E + EN ++ + LLS
Sbjct: 690 LQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVE-ENEALREEVILLSE 748
Query: 292 KTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAV---KEDA 348
+ SE E L +++KS + + K + ++H+ LL + K+D
Sbjct: 749 LKSLPSEVERLRKE--IQDKSEELHIITSEKDK-LFSEVVHKESRVQGLLEEIGKTKDDL 805
Query: 349 AATKDRCKQLTQEMMTEK-------ERSNVVIT---RMKDRIGTLEKEHNVFQN-----K 393
A T+ K QE K ++ +V+ RM I L KE F + K
Sbjct: 806 ATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALK 865
Query: 394 IHVSYQETQQMQMKFQQVREQMEAEIAHLKQ--ENGILRDAVSNTTNQLESKQSAELNKL 451
+SY+ TQ++Q K ++V+E++ E+ LK+ EN RD+ T + ++ + +L +
Sbjct: 866 TELSYK-TQELQEKTREVQERLN-EMEQLKEQLEN---RDSTLQTVEREKTLITEKLQQT 920
Query: 452 RQDYARLVNE---LTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAER-------RWEEVQ 501
++ L E L + LQ E Q K+ + + QE R + +E
Sbjct: 921 LEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETI 980
Query: 502 SYIRKRTAEHEA-----------AQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRL 550
+ ++ + +E + + + Q K V + + Q L +K T TL + + + +
Sbjct: 981 NTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKK-QDLEAKNTQTLTADVK-DNEI 1038
Query: 551 MQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQ-FHSQIAAQTSASVLAEELHK-- 607
++ + ++ LQ ++ ++ + E LK +++ I Q +L +EL K
Sbjct: 1039 IEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQ 1098
Query: 608 --VIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAA 665
V EK+ IK+ E L+ DRL EE+LK+ + ++ +Q +E
Sbjct: 1099 EIVAQEKNHAIKK-EGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKI 1157
Query: 666 HELEKMQQSVYVKDDKIRLLEEQ---LQHEISNKMEEFKILNDQNKALKSEVQKLQTLVS 722
+E+E ++ + K+ + +E + L +++ EE K + + K LK E+QK S
Sbjct: 1158 NEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLK-ELQK-----S 1211
Query: 723 EQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDL 782
+ +D + I+E + +E L+ I + +E ++ +R S T ++ +
Sbjct: 1212 FETERD---HLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINT 1268
Query: 783 KAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAEL----LKVANKEKTVQDLKQEI 838
Q+ + S L EE+ V+HE+ + +V+E+ E + L++ ++ T +D
Sbjct: 1269 ---QDLEKSHTKLQEEIP-VLHEEQELLPNVKEVSETQETMNELELLTEQSTTKD----- 1319
Query: 839 KALKEEIGNVQLEKAQQLSITSKVQELQNLLKG---KEEQMNTMKAVLEEKEKDLAN--- 892
+ +++E+ L + K QE Q +K + + + T+K LE K L
Sbjct: 1320 ---STTLARIEMER---LRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIR 1373
Query: 893 -TGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKE 951
T +Q+ Q + E +++E K S QF+ + L E E+ L L+E
Sbjct: 1374 ETLAKIQESQSKQEQ-SLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQE 1432
Query: 952 RESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKV----------- 1000
++ S + D+Q ++ +S+ +QLK+ + + EE LKV
Sbjct: 1433 SHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEET 1492
Query: 1001 -------ISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVEL-EAKEVLKKLFP 1052
+SE+E EIS + +L+++ D ++++ ++ E+++Q ++ E +E + +L
Sbjct: 1493 INELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNEL-- 1550
Query: 1053 KVSVPSNLSYGEWLHGFEKKAKECMAGTSGS-EEVKVLEHKLKEADEMHTLLQLECEKYK 1111
K + L E K E S EE++++ + +E + LQ+E ++ K
Sbjct: 1551 KQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLK 1610
Query: 1112 SVLAETEGILQKLQRSVEQEENKWKV----KVDESHKTIKQMQSSFTSSEQELERLRSEN 1167
T+ I+ K++ S E+E K+ + E I+ ++ F + + LE + +EN
Sbjct: 1611 E---NTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETEN 1667
Query: 1168 -----------KDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQ 1216
+++ ++ +ER+ L E ++ER +LK L ET+T+ +Q
Sbjct: 1668 IRLTQILHENLEEMRSVTKERDDLRSVEETLKVERD-------QLKENLRETITRDLEKQ 1720
Query: 1217 NERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVT 1276
E + V L + Q++++ ++ + + E S++ + E S + L
Sbjct: 1721 EELKIVHMHLKEHQETIDKLRGIVSEKTN-----EISNMQKDLEHSNDALKAQDL----- 1770
Query: 1277 QLQQLLQAVNQQLTKEKE 1294
++Q+ L+ + L +++E
Sbjct: 1771 KIQEELRIAHMHLKEQQE 1788
Score = 160 bits (406), Expect = 6e-39
Identities = 258/1343 (19%), Positives = 580/1343 (43%), Gaps = 180/1343 (13%)
Query: 29 MKETLYDEVLAKQKREQKLIPTKTDKKKAEKK----KNKKKEIQNGNL--HESDSESVPR 82
++E L ++ Q+++Q+L+ + + + +KK +N K E++N L ++E +
Sbjct: 1125 VEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLEL 1184
Query: 83 DFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQ-----VIKESDASK 137
KL++ N E S +ERK ++ QK E+ I+E +A+
Sbjct: 1185 AQKLNE--------------NYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATG 1230
Query: 138 IPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLH 197
+ K+ + ++ +K ++ + +K T K QE +P+
Sbjct: 1231 LQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHT-----KLQEEIPVL 1285
Query: 198 QETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKP 257
E ++ + K+ + +++ E + E +TT D+ + + +R ++
Sbjct: 1286 HEEQELLPNVKEVSETQETMNELELLTE---QSTT----KDSTTLARIEMERLRLNEKFQ 1338
Query: 258 DQVEGIQKSGTKKLKTETDKENAEVK-------FKDFLLSLKTMMFSEDEALCVVDLLKE 310
+ E I+ ++ +T KE EVK ++ L ++ ++++L + + E
Sbjct: 1339 ESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNE 1398
Query: 311 KSGVIQDALKKSSKG--------ELTTLIHQLQEK-DKLLAAVKEDAAATKDRCKQLTQE 361
+ ++ + + K E+ L +LQE D++ + KE KD ++L +
Sbjct: 1399 TTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKE-----KDDLQRLQEV 1453
Query: 362 MMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVR---EQMEAE 418
+ +E ++ +K+ I + +H + ++ V++ ++ + ++R + E E
Sbjct: 1454 LQSESDQ-------LKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETE 1506
Query: 419 IAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKN 478
I+ ++++ + D + N ++ K+ Q + ++E+ EK +L+Q + +K
Sbjct: 1507 ISTIQKQLEAINDKLQNKIQEIYEKEE-------QFNIKQISEVQEKVNELKQFKEHRKA 1559
Query: 479 AEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTD 538
+ A ++ ++ E R +E Q I+ E E ++ +Q + ++++ ++
Sbjct: 1560 KDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKR-VQEALQIERDQLKENTKEIVA 1618
Query: 539 TLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSA 598
+ Q+ E + +++ VN+ + +++ + EQ E K ++ ++ T
Sbjct: 1619 KMKESQEKEYQFLKMTA-----VNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQI 1673
Query: 599 -SVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQAL 657
EE+ V E+D ++ E++L ERD+L +N+ + +++K
Sbjct: 1674 LHENLEEMRSVTKERD-DLRSVEETLKVERDQLK---------ENLRETITRDLEK---- 1719
Query: 658 ANEQAAAAH-ELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQK 716
E+ H L++ Q+++ DK+R + + +EISN ++ + ND KA ++Q+
Sbjct: 1720 -QEELKIVHMHLKEHQETI----DKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQE 1774
Query: 717 LQTLVSE--QPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSS 774
+ + ++ ++++ + EK +KL +++ LE ++ K +EL A + +
Sbjct: 1775 ELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLIT 1834
Query: 775 LTKEVQDLKAKQND------QVSFASL-------------------VEELKKVIHEKDGK 809
L K+V + + K ++ Q+ SL +EE+K V+ E+D
Sbjct: 1835 LKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERD-N 1893
Query: 810 IKSVEEL--LEAELLKVANKEKTVQDL--KQEIKAL----KEEIGNVQLEKAQQLSITSK 861
++ VEE LE + LK + +E +DL +QE+K KE V + + T +
Sbjct: 1894 LRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQ 1953
Query: 862 VQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGK----------WLQDLQEENESLKAHV 911
+ ++Q L ++++ L++KE L + ++ L+++ E+ +
Sbjct: 1954 ISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSM 2013
Query: 912 QEVAQHNLKEASSASQ-FEELEIVLKEKENELKRLEAMLK-ERESDLSSKTQLL------ 963
Q V N + + EE+ IV KE++ EL+R++ LK ER+ +++ +++
Sbjct: 2014 QSVRMDNFQLTKKLHESLEEIRIVAKERD-ELRRIKESLKMERDQFIATLREMIARDRQN 2072
Query: 964 QDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVE 1023
V+ E +L + L + ++ S +ELLK SE + L L+ +E
Sbjct: 2073 HQVKPEKRLLSDGQQHLTESLREKCSRI---KELLKRYSEMDDHYECLNRLSLDLEKEIE 2129
Query: 1024 HQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGS 1083
Q++ + + + L+ K + +KLF +N H KK K + S
Sbjct: 2130 FQKELSMRVKANLSLPYLQTKHI-EKLF-----TANQRCSMEFHRIMKKLKYVL-----S 2178
Query: 1084 EEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQ-RSVEQEENKWKVKVDES 1142
K+ E + + ++ E EK K +L + + + Q S E + K +D
Sbjct: 2179 YVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLH 2238
Query: 1143 HKTIKQ--MQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRE 1200
+ I + +S F S + E +++ S K++ E + ++EK + + +
Sbjct: 2239 IEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQ 2298
Query: 1201 LKAQLNETLTKLRTEQNERQKVAGDLHKA-QQSLELIQSKIVKAAGD-----TTVIENSD 1254
+ N + + E E ++ + + K +Q L+ ++ K K + T++ +
Sbjct: 2299 VNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQ 2358
Query: 1255 VSPETESSEKETMSVSLNQTVTQ 1277
V+P T+ ++ ++ Q T+
Sbjct: 2359 VNPTTQDNKNPHVTSRATQLTTE 2381
Score = 154 bits (389), Expect = 5e-37
Identities = 297/1368 (21%), Positives = 568/1368 (41%), Gaps = 222/1368 (16%)
Query: 45 QKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDS-ESVPRDFKLSDALAVEDDQVAPVPLN 103
QKL + K K++ KE+Q E D R+ + + E+ ++A + L
Sbjct: 1186 QKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLK 1245
Query: 104 VVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVT--KQPTPPSEAAAS 161
+ + R EK Q+I D K K E +PV +Q P+ S
Sbjct: 1246 EHQETIDELRRSVSEKTA------QIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVS 1299
Query: 162 KKKPGQKKSKNGSDDQDKKVETLM--VPSKRQEALPLHQETKQESGSGKKKASSKKQKTE 219
+ + + + ++ K T + + +R QE+++E S K+ + K E
Sbjct: 1300 ETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKE 1359
Query: 220 NVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKEN 279
+ V + RE + ++ Q + Q K+ ET K
Sbjct: 1360 ALEVKHDQLKEHI----------------RETLAKIQESQSKQEQSLNMKEKDNETTKIV 1403
Query: 280 AEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQ-EKD 338
+E++ F ++ E E L + L+E ++ K+ K +L L LQ E D
Sbjct: 1404 SEME--QFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKE--KDDLQRLQEVLQSESD 1459
Query: 339 KLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVV------ITRMKDRIGTLEKE----HN 388
+L +KE A + ++L KE+ + ++ + I T++K+ ++
Sbjct: 1460 QLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAIND 1519
Query: 389 VFQNKIHVSYQETQQMQMK-FQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAE 447
QNKI Y++ +Q +K +V+E++ E+ K+ R A + +ESK
Sbjct: 1520 KLQNKIQEIYEKEEQFNIKQISEVQEKVN-ELKQFKEH----RKAKDSALQSIESKMLEL 1574
Query: 448 LNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKR 507
N+L++ + + EK + +E + +Q K + + + E+ ++ K
Sbjct: 1575 TNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFL-KM 1633
Query: 508 TAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESL 567
TA +E ++ + + + ++ E Q L+ + +T +L Q L + +E E + V KE
Sbjct: 1634 TAVNETQEKMCEIEHLKEQFETQKLNLENIET--ENIRLTQILHENLE-EMRSVTKERD- 1689
Query: 568 QMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASER 627
D+ E LK + Q + + + +E K++ K+ ++T D L
Sbjct: 1690 -----DLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIV 1744
Query: 628 DRLTSKEEEL-KDIQNMNFLLKAEVQKLQALANEQAAAAH--------ELEKMQQSVYVK 678
T++ + KD+++ N LKA+ K+Q E+ AH ++K++ V K
Sbjct: 1745 SEKTNEISNMQKDLEHSNDALKAQDLKIQ----EELRIAHMHLKEQQETIDKLRGIVSEK 1800
Query: 679 DDKIRLLEEQLQH---EISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEK 735
DK+ +++ L++ ++ K++E K Q LK +V + Q VSE +EQ++K
Sbjct: 1801 TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSE------MEQLKK 1854
Query: 736 CIQEKDEKLKTVEELLETGLIQVATKE-EELNAIRTENSSLTKEVQDLKAKQNDQVSFAS 794
I+++ L +E + L Q + EE+ ++ E +L + + LK ++
Sbjct: 1855 QIKDQSLTLSKLE-IENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLER-------- 1905
Query: 795 LVEELKKVIHEKDGK-IKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQ--LE 851
++LK+ + E + ++ +EL A +L +KE TV L+++I +I ++Q L+
Sbjct: 1906 --DQLKESLQETKARDLEIQQELKTARMLSKEHKE-TVDKLREKISEKTIQISDIQKDLD 1962
Query: 852 KAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHV 911
K++ + K+QELQ KE Q+ +K + K + ++ L+++ E+ +
Sbjct: 1963 KSKD-ELQKKIQELQK----KELQLLRVKEDVNMSHKKINE----MEQLKKQFEAQNLSM 2013
Query: 912 QEVAQHNLKEASSASQ-FEELEIVLKEKENELKRLEAMLK-ERESDLSSKTQLL------ 963
Q V N + + EE+ IV KE++ EL+R++ LK ER+ +++ +++
Sbjct: 2014 QSVRMDNFQLTKKLHESLEEIRIVAKERD-ELRRIKESLKMERDQFIATLREMIARDRQN 2072
Query: 964 QDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVE 1023
V+ E +L + L + ++ S +ELLK SE + L L+ +E
Sbjct: 2073 HQVKPEKRLLSDGQQHLTESLREKCSRI---KELLKRYSEMDDHYECLNRLSLDLEKEIE 2129
Query: 1024 HQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGS 1083
Q++ + + + L+ K + +KLF +N H KK K ++ +
Sbjct: 2130 FQKELSMRVKANLSLPYLQTKHI-EKLFT-----ANQRCSMEFHRIMKKLKYVLSYVT-- 2181
Query: 1084 EEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQ-RSVEQEENKWKVKVDES 1142
++K +H+ EM + E EK K +L + + + Q S E + K +D
Sbjct: 2182 -KIKEEQHESINKFEMDFID--EVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLH 2238
Query: 1143 HKTIKQ--MQSSFTSSEQELERLRSENKDIE-------NLRREREHLEMELEK------- 1186
+ I + +S F S + E +++ S K++ N R + E L+ ++K
Sbjct: 2239 IEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQ 2298
Query: 1187 ----------AEMERSTYVTE------------VRELK--------------------AQ 1204
A M ST E ++ LK AQ
Sbjct: 2299 VNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQ 2358
Query: 1205 LNETL------------TKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIEN 1252
+N T T+L TE+ +++ LH+A++S +SKI+K + V
Sbjct: 2359 VNPTTQDNKNPHVTSRATQLTTEKI--RELENSLHEAKESAMHKESKIIKMQKELEV--- 2413
Query: 1253 SDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
N + +LQ + N+ L K KE QVL+
Sbjct: 2414 ------------------TNDIIAKLQAKVHESNKCLEKTKETIQVLQ 2443
Score = 151 bits (381), Expect = 4e-36
Identities = 219/1030 (21%), Positives = 447/1030 (43%), Gaps = 164/1030 (15%)
Query: 336 EKDKLLAAVKE----DAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQ 391
EK+++ +KE D +R + QEM E SN +K+ + E + +
Sbjct: 520 EKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISN-----LKNLVKHAEVYNQDLE 574
Query: 392 NKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKL 451
N++ + ++ + + ++++E ++++ K EN ++ +S + +E + ++ +
Sbjct: 575 NELSSKVELLREKEDQIKKLQEYIDSQ----KLEN--IKMDLSYSLESIEDPK--QMKQT 626
Query: 452 RQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEH 511
D + + ++ L+ E ++ LK +++E ++++++ I+ ++
Sbjct: 627 LFDAETVALDAKRESAFLRSENLE----------LKEKMKELATTYKQMENDIQLYQSQL 676
Query: 512 EAA---QQDLQSKFVAKENEVQSLHS----KLTDTLVSKQQLEQRLMQLMESEQKRVNKE 564
EA Q DL+ + + NE+ L S K+ L+ +LE ++ L + K V +
Sbjct: 677 EAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEEN 736
Query: 565 ESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDK---------- 614
E+L+ +V +L + ++L +++++ +I ++ EELH + +EKDK
Sbjct: 737 EALREEVI-LLSELKSLPSEVERLRKEIQDKS------EELHIITSEKDKLFSEVVHKES 789
Query: 615 -------QIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHE 667
+I +T+D LA+ + S ++E ++ + ++ + QK + + E E
Sbjct: 790 RVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFE---QKYKMVLEENERMNQE 846
Query: 668 LEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNK 727
+ + + D + L+ +L ++ E+Q+ V E+ N+
Sbjct: 847 IVNLSKEAQKFDSSLGALKTELSYKTQ------------------ELQEKTREVQERLNE 888
Query: 728 DVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQN 787
+EQ+++ ++ +D L+TVE E LI E+L E +LT+E DLK Q
Sbjct: 889 --MEQLKEQLENRDSTLQTVER--EKTLIT-----EKLQQTLEEVKTLTQEKDDLKQLQE 939
Query: 788 DQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA------- 840
S ++LK IH+ +E L L + ++T+ LK +I
Sbjct: 940 ---SLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLH 996
Query: 841 LKEEIGNVQLEKAQQLSITSKVQELQ------------------------NLLKGKEEQM 876
++E G + E Q++ K Q+L+ +L++ K E
Sbjct: 997 MEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQ 1056
Query: 877 NTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLK 936
+++V+ EKE+ + + ++ E E L+ E+ + A + + E L
Sbjct: 1057 QMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELS 1116
Query: 937 EKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFK---SQIEQLKQQNYQQASSFPP 993
+ L +E LKE+ L K Q L +VQ+E + ++IE LK + + +
Sbjct: 1117 RTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEH 1176
Query: 994 HE----ELLKVISEREKEISGLWNE---LDSLKDAVEHQRKKNNERQQQVEAVELEAKEV 1046
E EL + ++E +E+ + E L L+ + E +R +++EA L+ KE
Sbjct: 1177 METERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEE 1236
Query: 1047 LKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLE 1106
L K++ + E + + E A ++++ ++ HT LQ E
Sbjct: 1237 L-----KIAHIHLKEHQETIDELRRSVSEKTAQIINTQDL----------EKSHTKLQEE 1281
Query: 1107 CEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSE 1166
VL E + +L ++ E +E ++++ T K S T + E+ERLR
Sbjct: 1282 I----PVLHEEQELLPNVKEVSETQETMNELELLTEQSTTK---DSTTLARIEMERLRLN 1334
Query: 1167 NK------DIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQ 1220
K +I++L +ER++L+ E E++ +RE A++ E+ +K N ++
Sbjct: 1335 EKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKE 1394
Query: 1221 KVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQ-TVTQLQ 1279
K D + E+ Q K +A IE +S + S E SV+ + + +LQ
Sbjct: 1395 K---DNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQ 1451
Query: 1280 QLLQAVNQQL 1289
++LQ+ + QL
Sbjct: 1452 EVLQSESDQL 1461
Score = 95.9 bits (237), Expect = 2e-19
Identities = 154/727 (21%), Positives = 302/727 (41%), Gaps = 98/727 (13%)
Query: 617 KQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVY 676
KQ E+ R + K++ + ++ + L K + +K++ L ++ + +
Sbjct: 357 KQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAK 416
Query: 677 VKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKC 736
K L + + + SN ++F I + + ++ KL + + ++ V + +
Sbjct: 417 RKRRVTWCLGKINKMKNSNYADQFNIPTN----ITTKTHKLSINLLREIDESVCSESDVF 472
Query: 737 IQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLV 796
D L +E T L+ E ELN++R + +L + + L+ ++
Sbjct: 473 SNTLDT-LSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKE--------- 522
Query: 797 EELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKE-----EIGNVQLE 851
E + K+K +L E E L+ K+ L EI LK E+ N LE
Sbjct: 523 --------EMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLE 574
Query: 852 KAQQLSITSKVQELQNLLKGKEEQMNTMKAV-----LEEKEKDLANTGKWLQDLQEENES 906
++SKV+ LL+ KE+Q+ ++ LE + DL+ + + ++D ++ ++
Sbjct: 575 N----ELSSKVE----LLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQT 626
Query: 907 LKAHVQEVAQHNLKEASSASQFEELEIVLKEKENEL----KRLEAMLKERESDLSSKTQL 962
L E + K S+ + E LE LKEK EL K++E ++ +S L +K ++
Sbjct: 627 L--FDAETVALDAKRESAFLRSENLE--LKEKMKELATTYKQMENDIQLYQSQLEAKKKM 682
Query: 963 LQDVQDENKLFKSQIEQLKQQ-----------NYQQASSFPP-HEELLKVISERE--KEI 1008
D++ E + ++I +L N + +EL K + E E +E
Sbjct: 683 QVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREE 742
Query: 1009 SGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHG 1068
L +EL SL VE RK+ ++ +++ + E ++ ++ K S L
Sbjct: 743 VILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGL-------- 794
Query: 1069 FEK--KAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGI------ 1120
E+ K K+ +A T + K + + + +H + +KYK VL E E +
Sbjct: 795 LEEIGKTKDDLATTQSN--YKSTDQEFQNFKTLHMDFE---QKYKMVLEENERMNQEIVN 849
Query: 1121 ----LQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRE 1176
QK S+ + + K E + +++Q EQ E+L + + ++ + RE
Sbjct: 850 LSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVERE 909
Query: 1177 REHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQ----QS 1232
+ + +L++ E T E +LK QL E+L Q ER ++ D+H +
Sbjct: 910 KTLITEKLQQTLEEVKTLTQEKDDLK-QLQESL------QIERDQLKSDIHDTVNMNIDT 962
Query: 1233 LELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKE 1292
E +++ + I E S M + +T + QQ + ++++ E
Sbjct: 963 QEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLE 1022
Query: 1293 KEHYQVL 1299
++ Q L
Sbjct: 1023 AKNTQTL 1029
Score = 83.6 bits (205), Expect = 1e-15
Identities = 197/1099 (17%), Positives = 440/1099 (40%), Gaps = 151/1099 (13%)
Query: 36 EVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDD 95
+++ K+K E K + ++ + K+N K+ + ES ++++ AV +
Sbjct: 1586 QIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMK------ESQEKEYQFLKMTAVNET 1639
Query: 96 QVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPV-PVTKQPTP 154
Q E + K++ + QK LE + ++I + +E + VTK+
Sbjct: 1640 Q---------EKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDD 1690
Query: 155 PSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSK 214
+ K + +N + + +E K++E +H K+ + K
Sbjct: 1691 LRSVEETLKVERDQLKENLRETITRDLE------KQEELKIVHMHLKEHQETIDKLRGIV 1744
Query: 215 KQKTENVF-VDEPLIHATTYIPLMD-------NADSSPVVDKREVIDLLKPDQVEGIQKS 266
+KT + + + L H+ + D + +++E ID L+ GI
Sbjct: 1745 SEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLR-----GIVSE 1799
Query: 267 GTKKLKT-ETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKG 325
T KL + D EN+ K ++ + LK +E + ++ L K+ + + KK S
Sbjct: 1800 KTDKLSNMQKDLENSNAKLQEKIQELKA---NEHQ---LITLKKD----VNETQKKVS-- 1847
Query: 326 ELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEK 385
E+ L Q++++ L+ ++ + + + +EM + + + +D + +E+
Sbjct: 1848 EMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKS--------VMKERDNLRRVEE 1899
Query: 386 EHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQS 445
+ ++++ S QET+ ++ QQ + K+ LR+ +S T Q+ Q
Sbjct: 1900 TLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQK 1959
Query: 446 AELNKLRQDYARLVNELTEKTGKL---------------QQEEVQKKNAEQAATQLKVQL 490
+L+K + + + + EL +K +L + E+++K+ Q + V++
Sbjct: 1960 -DLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRM 2018
Query: 491 QEAE--RRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQ-QLE 547
+ ++ E IR E + ++ +S + ++ + +L + + Q + E
Sbjct: 2019 DNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPE 2078
Query: 548 QRLMQ-----LMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLA 602
+RL+ L ES +++ ++ + L + ++ + E L +I Q S+
Sbjct: 2079 KRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRV 2138
Query: 603 EELHKVIAEKDKQIKQ---TEDSLASERDRLTSK------------EEELKDIQN--MNF 645
+ + + K I++ + E R+ K EE+ + I M+F
Sbjct: 2139 KANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDF 2198
Query: 646 LLKAEVQK-----LQALANEQAAAAHELE--KMQQSVYVKDDKIRLLEEQLQHEISNKME 698
+ + E QK +Q L + + EL K+ Q++ + ++I L++ + E +
Sbjct: 2199 IDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEI--LKDFSESEFPSIKT 2256
Query: 699 EFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQV 758
EF+ + L + + Q L + +E+++ IQ++++++ V +I +
Sbjct: 2257 EFQ------QVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAI 2310
Query: 759 ATK---------------EEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELK--- 800
+ E++L +++ +N L K Q LK ++ K
Sbjct: 2311 MNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPH 2370
Query: 801 ---KVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLS 857
+ KI+ +E L +KE + +++E++ + I +Q + +
Sbjct: 2371 VTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNK 2430
Query: 858 ITSKVQELQNLLKGK--------EEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKA 909
K +E +L+ K +E++ +K L + + + K + ++E + KA
Sbjct: 2431 CLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAK---EFEKEISATKA 2487
Query: 910 HV--QEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQ 967
V Q+ L+E SQ + V+ E + + + S + T+ L ++
Sbjct: 2488 TVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKAL-ILK 2546
Query: 968 DENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRK 1027
E+ + +I +LKQQN Q ELL E+ W E ++A +
Sbjct: 2547 SEHIRLEKEISKLKQQNEQLIKQ---KNELLSNNQHLSNEVK-TWKERTLKREAHKQVTC 2602
Query: 1028 KNNERQQQVEAVELEAKEV 1046
+N+ + +V + K++
Sbjct: 2603 ENSPKSPKVTGTASKKKQI 2621
Score = 58.2 bits (139), Expect = 5e-08
Identities = 121/611 (19%), Positives = 245/611 (40%), Gaps = 173/611 (28%)
Query: 821 LLKVANKEKTVQDLKQEI-----------------------KALKEEIGNVQLEKAQQLS 857
LLK KE + DLK+++ K L +++ N ++E ++
Sbjct: 344 LLKRYRKE--IMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRML 401
Query: 858 ITSKVQELQNLLKGKEE--------QMNTMK-----------------------AVLEEK 886
+TS LQ LK K + ++N MK +L E
Sbjct: 402 VTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREI 461
Query: 887 EKDL-------ANTGKWLQDLQEENESLKAHVQEVAQHNLKEASS------------ASQ 927
++ + +NT L ++ E N + K QE + L + ++
Sbjct: 462 DESVCSESDVFSNTLDTLSEI-EWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTE 520
Query: 928 FEELEIVLKEKENELKRLEAMLK-----------------------------ERESDLSS 958
EE+E+ LKEK N+L EA+ + + E++LSS
Sbjct: 521 KEEMELKLKEK-NDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSS 579
Query: 959 KTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHE------------ELLKVISEREK 1006
K +LL++ +D+ K + I+ K +N + S+ + V + ++
Sbjct: 580 KVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKR 639
Query: 1007 EISGLWNELDSLKD-----AVEHQRKKNNER--QQQVEA---VELEAKEVLKKLFPKVS- 1055
E + L +E LK+ A +++ +N+ + Q Q+EA ++++ ++ L+ F +++
Sbjct: 640 ESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITK 699
Query: 1056 --------VPSNLSYGEWLHG----FEKKAKECMAGTSGSEEVKVLEHKLK----EADEM 1099
VP +L L G +K+ + + E +L +LK E + +
Sbjct: 700 LTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERL 759
Query: 1100 HTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKT---IKQMQSSFTSS 1156
+Q + E+ + +E + KL V +E++ + ++E KT + QS++ S+
Sbjct: 760 RKEIQDKSEELHIITSEKD----KLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKST 815
Query: 1157 EQELERLRSENKDIEN----LRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKL 1212
+QE + ++ + D E + E E + E+ E + + + LK +L+ +L
Sbjct: 816 DQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQEL 875
Query: 1213 RTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLN 1272
+ + E Q+ ++ + ++ L EN D + +T EK ++ L
Sbjct: 876 QEKTREVQERLNEMEQLKEQL-----------------ENRDSTLQTVEREKTLITEKLQ 918
Query: 1273 QTVTQLQQLLQ 1283
QT+ +++ L Q
Sbjct: 919 QTLEEVKTLTQ 929
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 173 bits (438), Expect = 1e-42
Identities = 283/1403 (20%), Positives = 590/1403 (42%), Gaps = 213/1403 (15%)
Query: 34 YDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALA-V 92
YDE+ + ++ + + D K E ++ K+K +Q ++ E + R +L + LA +
Sbjct: 963 YDEMSPAGQISKEELQHEFDLLKKENEQRKRK-LQAALINRK--ELLQRVSRLEEELANL 1019
Query: 93 EDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEE-QVIKESDASKIPGKKVEPVPVTKQ 151
+D+ +PL+ E +++ KE +K V + Q I+ I K+VE + K
Sbjct: 1020 KDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKD 1079
Query: 152 PTPPSEAAASKKKPGQKKSKNGS-DDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKK 210
+ AA ++ K N + D+ +++ L +A+ T S
Sbjct: 1080 LE--EKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDS 1137
Query: 211 ASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKK 270
+ K E V + P ++ + KP+ E I
Sbjct: 1138 VALVK---ETVVISPPCTGSSEH---------------------WKPELEEKI------- 1166
Query: 271 LKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTL 330
L E +KE + K ++ L S K ++ +EK +++ LK+ K + L
Sbjct: 1167 LALEKEKEQLQKKLQEALTSRKA----------ILKKAQEKERHLREELKQQ-KDDYNRL 1215
Query: 331 IHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMM--TEKERSNVVITRMKDRIGTLEKEHN 388
Q E+ K + + + + ++ + T+++ S +++ + ++H+
Sbjct: 1216 QEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHH 1275
Query: 389 ---VFQNKIHVSYQETQQMQMKFQQVRE--QMEAEIAHLKQENGILRDAVSNTTNQLESK 443
V ++ + + + Q Q++A++ ++ E L VS+TT++L +K
Sbjct: 1276 TQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSEL-TK 1334
Query: 444 QSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQA--ATQLKV------------- 488
+S E+ +L++ + E+ + EV ++ +Q ++QL++
Sbjct: 1335 KSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKL 1394
Query: 489 -QLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLT---------- 537
+LQ+ + EE SY+ + +E EAA +Q++ + +E+ +++LH++L
Sbjct: 1395 DELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERI 1454
Query: 538 ------------------DTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNE 579
+ +KQQ++++L + S ++ + + +SLQ ++ E
Sbjct: 1455 KQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIE 1514
Query: 580 ALKAQIQQFHSQIAAQTSA--------SVLAEELHKVIAEKDKQIKQTE------DSLAS 625
L + SQ++AQ ++L EE K+I E D+ + + + +SL
Sbjct: 1515 RLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKL 1574
Query: 626 ERDRLTSKEEEL-KDIQNMNFLLKAEVQKLQA-----------LANEQAAAAHELEKMQQ 673
+ LT +E+L K+I+++ AE + Q L ++E E++Q
Sbjct: 1575 ALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQH 1634
Query: 674 SVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNK--DVVE 731
V + + L +L+ +NK E K L + + ++ +K++ + K ++ E
Sbjct: 1635 VVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEE 1694
Query: 732 QMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVS 791
+ ++ E T +E +ET L A+ +EEL ++ E +L+K+ Q L ++++
Sbjct: 1695 ENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKD---- 1750
Query: 792 FASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLE 851
SL EE++ + H+ +G + L E K N+ ++ Q I EE ++ +
Sbjct: 1751 --SLSEEVQDLKHQIEGNVSKQANLEATE--KHDNQTNVTEEGTQSIPGETEEQDSLSMS 1806
Query: 852 KAQQLSIT---------------SKVQELQNLLKGKEEQMNTMKAVLEEKEKD------L 890
S + S E+ N L+ ++ + + EEK+K+ L
Sbjct: 1807 TRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTL 1866
Query: 891 ANT-GKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEEL----EIVLKEKENELKRL 945
N L + ++ LK +EV + NL + + E +EK++ +RL
Sbjct: 1867 ENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERL 1926
Query: 946 EAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISERE 1005
L E + + Q + D Q +N+L +S+++ LK+ + EE +++ E+
Sbjct: 1927 MNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSEL------EEEKQQLVKEKT 1980
Query: 1006 KEISGLWNE-LDSLKDAVEHQRKKNN--ERQQQVEAVELEAKEVLKKLFPKVSVPSNLSY 1062
K S + E L+ ++ A + K++ E Q+ ++ + E K++ K + Y
Sbjct: 1981 KVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDC---------IRY 2031
Query: 1063 GEWLHGFEKKAKEC-MAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEG-- 1119
E + E+ K T +++++ + L +A E Q E +K +L +T+
Sbjct: 2032 QEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEA 2091
Query: 1120 ---ILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRE 1176
+ L+ E + NK VK K + + E+ L+ ++ + ++ LRRE
Sbjct: 2092 ARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRRE 2151
Query: 1177 REHLEMELEKAEMERSTYVTEVRELKAQLNETLTKL-------RTEQNERQKVAGDLHKA 1229
+ HLE + + ++ + EV++L+ L+ T+T+L + Q++R +V + K
Sbjct: 2152 KVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKW 2211
Query: 1230 QQSL-ELIQSK--IVKAAGDTTVIENSDVSPETESSEKETMSV-----------SLNQTV 1275
++ + IQSK ++ D + + + E+ +++ S QT
Sbjct: 2212 ERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTE 2271
Query: 1276 TQLQQ----LLQAVNQQLTKEKE 1294
QLQQ LQ N++L + E
Sbjct: 2272 VQLQQKVCDTLQGENKELLSQLE 2294
Score = 158 bits (399), Expect = 4e-38
Identities = 282/1356 (20%), Positives = 557/1356 (41%), Gaps = 169/1356 (12%)
Query: 38 LAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQV 97
L Q+ +++L K+ AE++K+ +E L E + ++DA ++++ +
Sbjct: 1896 LLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDA-QIKNELL 1954
Query: 98 APVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSE 157
N+ + S + E K++ K+K +E ++ KE KI G + EP K +
Sbjct: 1955 ESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEY-LEKIQGAQKEPG--NKSHAKELQ 2011
Query: 158 AAASKKKPGQKKSKNGSDDQDKKVETL--------MVPSKRQEALPLHQETKQESGSGKK 209
+K+ K+ + +K+ L V ++ Q+ L + +E ++ +K
Sbjct: 2012 ELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRK 2071
Query: 210 KASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTK 269
KA ++ ++ L+D+ S + + L K Q
Sbjct: 2072 KAQAE---------------LASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQM 2116
Query: 270 KLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKG---- 325
K K E + E + L K M D L+E G IQ L K K
Sbjct: 2117 KQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQL 2176
Query: 326 --ELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTL 383
L + + QL K ++++++D D K+ ++ + I +D L
Sbjct: 2177 QENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVL 2236
Query: 384 EKEH-----NVFQNKIHVSYQE-TQQMQMKFQQVREQMEAEIAH-LKQENGILRDAVSNT 436
+ + ++ + KI++S E +Q+ Q Q++ ++ L+ EN L + T
Sbjct: 2237 KDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEET 2296
Query: 437 TNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERR 496
+ S Q+ EL KL + L ++LT+ + L++ + QK N E Q + +Q ++
Sbjct: 2297 RHLYHSSQN-ELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFS 2355
Query: 497 WEEVQSYI---RKRTAE-HEAA---QQDLQSKFVAKENEVQSLHSKLT----------DT 539
+E++++ + R+ T+ HE +Q + S KE +Q ++L +
Sbjct: 2356 YEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELEN 2415
Query: 540 LVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQF-HSQIAAQTSA 598
L+S+++ E +++ E +K V+K L ++ I ++N KAQ+ F S + Q
Sbjct: 2416 LLSQEEEENIVLE--EENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDR 2473
Query: 599 SVLA------EELH-KVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEV 651
+ EE H +I EKD+ I++ ++ + + D+ + N L AE+
Sbjct: 2474 DRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAEL 2533
Query: 652 QKLQALANEQAAAAHELEKMQQSVYVK-----DDKIRLLEEQLQH-EISNK--MEEFKIL 703
+ + N+ +K V ++ ++K LEE+L+ E +N+ F L
Sbjct: 2534 IQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNAL 2593
Query: 704 NDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCI-------QEKDEKLKTVEELLETGLI 756
++ + L E++ L+ +S+ + Q E + + K+E++ + L +
Sbjct: 2594 QEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQK 2653
Query: 757 QVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEEL 816
++A EEEL ++ E + E++D L +ELK +H G +++ E
Sbjct: 2654 RIAELEEELVCVQKEAAKKVGEIED------------KLKKELKH-LHHDAGIMRNETET 2700
Query: 817 LEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQM 876
E +VA + + +++Q++ + +E + AQ S + LQN E++
Sbjct: 2701 AEE---RVAELARDLVEMEQKLLMVTKENKGL---TAQIQSFGRSMSSLQNSRDHANEEL 2754
Query: 877 NTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVA-QHNLKEASSASQFEELEIVL 935
+ +K + K+LA L++ N A + E A N E +S S E+L L
Sbjct: 2755 DELKRKYDASLKELAQ----LKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQL 2810
Query: 936 KEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQL------KQQNYQQAS 989
K+ +L L + L++ + + S ++ + +Q+E +++E+ KQ++ Q S
Sbjct: 2811 LSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPS 2870
Query: 990 SFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQV--------EAVEL 1041
+ P + LK K +S L N+ D L +++ +++ + Q++ + E
Sbjct: 2871 TSPAEVQSLK------KAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEY 2924
Query: 1042 EAKEVLKKLFPKVSVPSNLSYGEWLH--GFEKKAKECMAGTSGSEEVKVLEHKLKEADEM 1099
+ K ++ + NLS+ LH EK + E + + + K ++ +
Sbjct: 2925 QDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHL 2984
Query: 1100 HTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQE 1159
L++ + +S ++T+ + + QR E + D S + E
Sbjct: 2985 QNLIR----ELRSSSSQTQPLKVQYQRQASPETS---ASPDGSQNLV-----------YE 3026
Query: 1160 LERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNER 1219
E LR++ + + +E E+ +++ S + E L QL +T LR E
Sbjct: 3027 TELLRTQ---LNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLR----EN 3079
Query: 1220 QKVAGD-------LHKAQQSLELIQSKIVKAAG----DTTVIENSDV----SPETESSEK 1264
Q+ GD L K Q L+ I A G V SD P+ SE
Sbjct: 3080 QQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEA 3139
Query: 1265 ETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
+ + Q V +L++LL+ Q + V E
Sbjct: 3140 QQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAE 3175
Score = 148 bits (374), Expect = 3e-35
Identities = 223/1083 (20%), Positives = 467/1083 (43%), Gaps = 138/1083 (12%)
Query: 306 DLLKEKSGVIQDALKKSSKGELTTLIHQL--QEKDKLLAAVKEDAAATKDRCKQLT---Q 360
+L KE ++Q S++ E + + QEK +L ++ A K+ KQL Q
Sbjct: 1610 ELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQ 1669
Query: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
EM KE+ + +I LE+E++ + ++H + ++ M+ E+
Sbjct: 1670 EMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELE 1729
Query: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
+K E L + ++ +S L++ QD + K L E +K + +
Sbjct: 1730 RVKMEYETLSKKFQSLMSEKDS-----LSEEVQDLKHQIEGNVSKQANL--EATEKHDNQ 1782
Query: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL 540
T+ Q E ++ S + T + V+K+ S H ++ + L
Sbjct: 1783 TNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKD---FSSHDEINNYL 1839
Query: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSAS- 599
QL++R+ L E +QK ++L+ + +L Q +++ ++ +
Sbjct: 1840 QQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQ 1899
Query: 600 VLAEELHKVI-------AEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQ 652
+ EEL +V EKD ++ + LA + + +++ D Q N LL++E++
Sbjct: 1900 QIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMK 1959
Query: 653 KLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKS 712
L+ + ELE+ +Q + + K+ E +++ E K++ + + KS
Sbjct: 1960 NLKKCVS-------ELEEEKQQLVKEKTKV---ESEIRKEYLEKIQGAQ----KEPGNKS 2005
Query: 713 EVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTEN 772
++LQ L+ E+ + V+Q++K EK+ +E ++ L V T+ ++ I EN
Sbjct: 2006 HAKELQELLKEKQQE--VKQLQKDCIRYQEKISALERTVK-ALEFVQTESQKDLEITKEN 2062
Query: 773 SSLTKEVQDLKAKQNDQVSFASLVEE--------------LKKVIHEKDGKIKS------ 812
L + V+ K Q + SF L+++ LKK + +KS
Sbjct: 2063 --LAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKD 2120
Query: 813 ------VEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQ 866
+E+ E L + N ++ + L++E L+E IG +Q+ ++ +VQ+LQ
Sbjct: 2121 EDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKK---DKEVQQLQ 2177
Query: 867 NLLKGKEEQM----NTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEA 922
L Q+ +M ++ +++++ + KW + + +S + ++ LKE
Sbjct: 2178 ENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIR------LKED 2231
Query: 923 SSA---SQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDV----QDENKLFKS 975
+ + Q ++ I ++E + + RLE + ES ++ QL Q V Q ENK S
Sbjct: 2232 NCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLS 2291
Query: 976 QIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLK------DAVEHQRKKN 1029
Q+E+ + + + E LK + + +++ L N L+ K + + Q++ +
Sbjct: 2292 QLEETRHLYHSSQNELAKLESELKSLKD---QLTDLSNSLEKCKEQKGNLEGIIRQQEAD 2348
Query: 1030 NERQ----QQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMA--GTSGS 1083
+ +Q+E ++E+ +L ++++ L G E+ + +A
Sbjct: 2349 IQNSKFSYEQLETDLQASRELTSRLHEEINMKEQ-KIISLLSGKEEAIQVAIAELRQQHD 2407
Query: 1084 EEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESH 1143
+E+K LE+ L + +E + +L+ E+ K + +T +++ L +++++E + K ++D
Sbjct: 2408 KEIKELENLLSQEEEENIVLE---EENKKAVDKTNQLMETL-KTIKKENIQQKAQLDSFV 2463
Query: 1144 KTIKQMQ------------------SSFTSSEQELERLRSEN----KDIENLRREREHLE 1181
K++ +Q S +Q ++ +EN ++I LR + L
Sbjct: 2464 KSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLN 2523
Query: 1182 MELEKAEMERSTY---VTEVRELKAQLNETLTKLRTEQNE--RQKVAGDLHKAQQSLELI 1236
E K + E Y + +V +K + L +++ +QN+ K A K ++S E
Sbjct: 2524 SENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEE-- 2581
Query: 1237 QSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQL-TKEKEH 1295
++ ++ + + E D+S E ES + ++ T Q + L + QL KE+E
Sbjct: 2582 ANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEV 2641
Query: 1296 YQV 1298
+++
Sbjct: 2642 HRL 2644
Score = 144 bits (364), Expect = 4e-34
Identities = 243/1156 (21%), Positives = 487/1156 (42%), Gaps = 150/1156 (12%)
Query: 182 ETLMVPSK---RQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMD 238
E L+V K RQ+ + L Q K E+ ++KA+ K K + L YI M
Sbjct: 58 EQLVVELKDIIRQKDVQLQQ--KDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEM- 114
Query: 239 NADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSE 298
A V+ +P E + K K TE + E ++K K + +
Sbjct: 115 KAQGGTVLPT-------EPQSEEQLSKHD--KSSTEEEMEIEKIKHK---------LQEK 156
Query: 299 DEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQL 358
+E + + ++ Q A + E + QLQEK++ ++ ++ + T+ +Q
Sbjct: 157 EELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQ--AEQA 214
Query: 359 TQEMMTEKE-RSNVVITRMKDRIGTLEKEHNV---FQNKIHV---SYQETQQMQMKFQQV 411
Q+++ EK+ R + +D + L + +V Q K+ V +E ++ + QV
Sbjct: 215 AQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQV 274
Query: 412 REQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQ 471
+ ++ E+ +Q N IL S Q+E AE N LR E K++
Sbjct: 275 VDLLQQELTAAEQRNQIL----SQQLQQME----AEHNTLRNTVETEREESKILLEKMEL 326
Query: 472 EEVQKK----NAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKEN 527
E ++K N ++ L Q ++A + E++S +H+A ++ S ++ +
Sbjct: 327 EVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQK 386
Query: 528 EVQSLHSKLTDTLVSKQQ--LEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQI 585
Q L S D L + L+ + Q ++S Q E+ LQ + ++I + L Q
Sbjct: 387 TGQELQSAC-DALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQ- 444
Query: 586 QQFHSQIAAQTS-ASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMN 644
+ A+QTS V E V E +++ L +E+ L EL++++ N
Sbjct: 445 ---QHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAEN 501
Query: 645 FLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQ----LQHEISNKMEEF 700
L +++ L+A N A E+ ++ V + + + EE L++ S K +E
Sbjct: 502 EKLSSQITLLEA-QNRTGEADREVSEIS-IVDIANKRSSSAEESGQDVLENTFSQKHKEL 559
Query: 701 KILNDQNKALKSEVQ----KLQTLVSEQPNKDVVEQMEKCIQEKDE----KLKTVEELLE 752
+L + K + E+ +LQ +E+ + +V++Q E E + K+K E
Sbjct: 560 SVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTG 619
Query: 753 TGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKS 812
+ +E L A+ E +S + ++ ++++S ELK + D + +
Sbjct: 620 QDFPLMPNEESSLPAVEKEQASTEHQ-----SRTSEEISLNDAGVELKSTKQDGDKSLSA 674
Query: 813 VEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLE--KAQQLSITSKVQELQNLLK 870
V ++ + + E++ LK +I ++L KAQ++ + L
Sbjct: 675 VPDIGQCH--------------QDELERLKSQILELELNFHKAQEI--------YEKNLD 712
Query: 871 GKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVA------------QHN 918
K ++++ + ++EE +K+ N L EE + L + V+E++ + N
Sbjct: 713 EKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMN 772
Query: 919 LKEASS----------------ASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQL 962
L EA Q L I K K+ +++ L+ L + + S ++ L
Sbjct: 773 LAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTL 832
Query: 963 LQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAV 1022
++ +Q + + +S++ + ++ +S EEL + +S++E EI+ + L K V
Sbjct: 833 IRSLQSQLQNKESEVLEGAERVRHISSKV---EELSQALSQKELEITKMDQLLLEKKRDV 889
Query: 1023 EHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSG 1082
E ++ E+ QQV + E + +L + S G + K KE + S
Sbjct: 890 ETLQQTIEEKDQQVTEISFSMTEKMVQLNEE-----KFSLGVEI----KTLKEQLNLLSR 940
Query: 1083 SEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDES 1142
+EE K + +++E +E+ + L+ ++ ++ LQ +++E + K K+ +
Sbjct: 941 AEEAK--KEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAA 998
Query: 1143 HKTIKQMQSSFTSSEQELERLRSEN-KDIENLRREREHLEMELEKAEMERSTYVTEVREL 1201
K++ + E+EL L+ E+ K+I ER +E + E E ++ +E+
Sbjct: 999 LINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEI 1058
Query: 1202 KAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETES 1261
+ L +T+++ ++ E Q + DL + + E Q+ + + N + +T
Sbjct: 1059 EIYLKQTISE---KEVELQHIRKDLEEKLAAEEQFQALVKQM--------NQTLQDKTNQ 1107
Query: 1262 SEKETMSVSLNQTVTQ 1277
+ +S NQ + Q
Sbjct: 1108 IDLLQAEISENQAIIQ 1123
Score = 127 bits (319), Expect = 7e-29
Identities = 296/1563 (18%), Positives = 598/1563 (38%), Gaps = 352/1563 (22%)
Query: 72 LHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQ-------KPV 124
+ + D + +D L + D+++ + L+ +S+ + ++ K Q +P
Sbjct: 68 IRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQ 127
Query: 125 LEEQVIKESDASKIPGKKVEPVPVTKQPTPP--SEAAASKKKPGQKKSKNGSDDQDKKVE 182
EEQ+ K +S ++E + Q S A + ++ S + ++ V
Sbjct: 128 SEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVM 187
Query: 183 TLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNAD- 241
+++E + Q ++ ++ A ++ + F + +H + L+ AD
Sbjct: 188 MKQQLQEKEEFISTLQAQLSQT-QAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADV 246
Query: 242 ------------------SSPVVDKREVIDLLKPDQVEGIQKS--------------GTK 269
+V + +V+DLL+ + Q++ T
Sbjct: 247 ETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTL 306
Query: 270 KLKTETDKENAEVKFKDFLLSLKTMMFS----EDEALCVVDLLKEKSGVIQ-------DA 318
+ ET++E +++ + L + S ++E +++ E++G Q A
Sbjct: 307 RNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQF-EQAGQAQAELESRYSA 365
Query: 319 LKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKD 378
L++ K E+ + K ++ A KD+ +L Q+ + +S I +++D
Sbjct: 366 LEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLED 425
Query: 379 RIGTLEKEHNVFQNKIHVSYQETQQ----------------------MQMKFQQVREQME 416
++ KE + F N++ + ET +Q + ++ +
Sbjct: 426 QLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKG 485
Query: 417 A------EIAHLKQENGILRDAVS-----NTTNQLE------------SKQSAELNKLRQ 453
A E+ LK EN L ++ N T + + +K+S+ + Q
Sbjct: 486 ALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQ 545
Query: 454 DYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQ--EAERRWEEVQSYIRKRTAEH 511
D L N ++K +L ++ K A++ LK+QLQ AE EV + E
Sbjct: 546 DV--LENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEG 603
Query: 512 EAAQ--------QDLQSKFVAKENEVQSL-----------HSKLTDTLVSKQQLEQRLMQ 552
E +D F NE SL H T +S L
Sbjct: 604 EGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKS 663
Query: 553 LMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQ----FH-SQIAAQTSASVLAEE--- 604
+ K ++ + QD LE+ LK+QI + FH +Q + + A+E
Sbjct: 664 TKQDGDKSLSAVPDIGQCHQDELER---LKSQILELELNFHKAQEIYEKNLDEKAKEISN 720
Query: 605 LHKVIAEKDKQIKQTEDS---LASERDRLTSKEEELKDIQNMNFLLK------AEVQKLQ 655
L+++I E K + L+ ERD+L S+ +EL + + +K AE ++ +
Sbjct: 721 LNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQR 780
Query: 656 ALANEQAAA-----AHELEKMQQSVYVKDDKIRLLEEQL-----------------QHEI 693
L E A ++ + KD KI +L+ +L Q ++
Sbjct: 781 RLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQL 840
Query: 694 SNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLET 753
NK E ++ + + S+V++L +S++ + + +M++ + EK ++T+++ +E
Sbjct: 841 QNKESEVLEGAERVRHISSKVEELSQALSQKELE--ITKMDQLLLEKKRDVETLQQTIEE 898
Query: 754 GLIQVA----TKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGK 809
QV + E++ + E SL E++ LK +Q++ S EE KK E+D +
Sbjct: 899 KDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLK----EQLNLLSRAEEAKKEQVEEDNE 954
Query: 810 IKS----------------VEELL-EAELLKVANKEK---------TVQDLKQEIKALKE 843
+ S EEL E +LLK N+++ ++L Q + L+E
Sbjct: 955 VSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEE 1014
Query: 844 EIGNVQLEKAQQLS----------------------ITSKVQELQNLLKG----KEEQMN 877
E+ N++ E +++ +TSK QE++ LK KE ++
Sbjct: 1015 ELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQ 1074
Query: 878 TMKAVLEEK-------EKDLANTGKWLQDLQEENESLKAHVQE---VAQHNLKEASSASQ 927
++ LEEK + + + LQD + + L+A + E + Q + + AS
Sbjct: 1075 HIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASD 1134
Query: 928 FEELEIVL----------------------------KEKENELKRLEAML--------KE 951
+ + +V KEKE K+L+ L K
Sbjct: 1135 GDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKA 1194
Query: 952 RESDLSSKTQLLQDVQDENKLFKSQIEQLKQ--------------------------QNY 985
+E + + +L Q D N+L + EQ K+
Sbjct: 1195 QEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQ 1254
Query: 986 QQASSFPPHEELLKVISER-------EKEISGLW----NELDSLKDAVEHQRKKNNERQQ 1034
+ SS P EE L +E+ E + W + +L+ + K ++
Sbjct: 1255 ESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEI 1314
Query: 1035 QVEAVELEAK-------------------EVLKKLFPKVSVPSNLSYGEWLH--GFEKKA 1073
+ E VELE K E + K ++ +S+ +H ++K
Sbjct: 1315 EAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKL 1374
Query: 1074 KECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEEN 1133
+ +G E ++ L+ KL E ++ + + + L+E E L K+Q + ++E+
Sbjct: 1375 ESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQED 1434
Query: 1134 KWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERST 1193
K + K+ + EL ++ + ++I R ++ ++ +L+ A + R
Sbjct: 1435 LIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKE 1494
Query: 1194 YVTEVRELKAQLN------ETLTK--------LRTEQNERQKVAGDLHKAQQSLELIQSK 1239
+ E + L+ +L+ E LTK + + E+ V G L Q+ + + ++
Sbjct: 1495 ALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITE 1554
Query: 1240 IVKAAGDTTVIENSDVSPETESSE--KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1297
+ D +++EN +S ES + E ++ + V +++ L + + T+ +E ++
Sbjct: 1555 M-----DRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHK 1609
Query: 1298 VLE 1300
L+
Sbjct: 1610 ELQ 1612
Score = 125 bits (315), Expect = 2e-28
Identities = 169/931 (18%), Positives = 407/931 (43%), Gaps = 94/931 (10%)
Query: 387 HNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSA 446
+N Q + +Q+ ++ + + Q + ++ + R A N +L+ A
Sbjct: 43 NNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKA 102
Query: 447 ELNKLRQDYARLVNELTEKTGKL----QQEEVQKKNAEQAATQLKVQLQEAERRWEEVQS 502
+L L + + E+ + G + Q E Q ++++T+ ++++++ + + +E +
Sbjct: 103 KLTSLN----KYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEE 158
Query: 503 YIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVN 562
I A+ AQ E QS +++ + ++ KQQL+++ + + + Q +++
Sbjct: 159 LISTLQAQLTQAQA---------EQPAQS-STEMEEFVMMKQQLQEK-EEFISTLQAQLS 207
Query: 563 KEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDS 622
+ ++ Q Q + E++ + Q++ ++ + + + E+ + + +++++ E+S
Sbjct: 208 QTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEES 267
Query: 623 LASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKI 682
L + ++EL + N +L ++Q+++A E ++ +V + ++
Sbjct: 268 LVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEA----------EHNTLRNTVETEREES 317
Query: 683 RLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNK-DVVEQMEKCIQEKD 741
++L E+++ E++ + F L ++ L + ++ +E ++ +EQ K E +
Sbjct: 318 KILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKA--EME 375
Query: 742 EKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKK 801
EK + L +TG + +A++ +NS L L+ K V A +++L+
Sbjct: 376 EKTSHILSLQKTG----QELQSACDALKDQNSKL------LQDKNEQAVQSAQTIQQLED 425
Query: 802 VIHEKDGKIKSVEELLEAELLKVANK--------EKTVQDLKQEIKALKEEIGNVQLEKA 853
+ +K +I L + + A++ E T ++ I +L++ + ++ EK
Sbjct: 426 QLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKG 485
Query: 854 QQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQE 913
L + +++E LK + E++++ +LE + + TG + + E + + +
Sbjct: 486 ALLLSSIELEE----LKAENEKLSSQITLLEAQNR----TG------EADREVSEISIVD 531
Query: 914 VAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLF 973
+A A + Q + LE +K EL L +KE + +++ LQ + E
Sbjct: 532 IANKRSSSAEESGQ-DVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAE---- 586
Query: 974 KSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQ 1033
++ E L Q+ +Q +KV E + L +S AVE ++ +
Sbjct: 587 EADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQS 646
Query: 1034 QQVEAVEL-----EAKEVLKKLFPKVSVPSNLS--YGEWLHGFEKKAKECMAGTSGSEEV 1086
+ E + L E K + +S ++ + + L + + E ++E+
Sbjct: 647 RTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEI 706
Query: 1087 --KVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQ--EENKWKVKVDES 1142
K L+ K KE ++ L+ E++K L +Q + K V E
Sbjct: 707 YEKNLDEKAKEISNLNQLI----EEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTEL 762
Query: 1143 HKTIKQMQSSFTSSEQELERLRSENKDI-ENLRREREH-LEMELEKAEMERSTYVTEVRE 1200
+KQ++ + +E++ RL E++ +NL E+ H L +E + +++ E+ +
Sbjct: 763 RAQVKQLEMNLAEAERQ-RRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDD 821
Query: 1201 LKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETE 1260
++ Q +E T +R+ Q++ Q ++ + + + I SK+ + + + E E
Sbjct: 822 VQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEE-------LSQALSQKELE 874
Query: 1261 SSEKETMSVSLNQTVTQLQQLLQAVNQQLTK 1291
++ + + + + V LQQ ++ +QQ+T+
Sbjct: 875 ITKMDQLLLEKKRDVETLQQTIEEKDQQVTE 905
Score = 86.7 bits (213), Expect = 1e-16
Identities = 166/804 (20%), Positives = 321/804 (39%), Gaps = 120/804 (14%)
Query: 175 DDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYI 234
D + K++E L+ + + + + K + + + K K EN+ L +
Sbjct: 2407 DKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSM 2466
Query: 235 PLMDNADSSPVVD-----KREVIDLLKPDQVEGIQKSGTKKLKTET----------DKEN 279
+ N V D +R + +L+ DQ+ + KLK E + EN
Sbjct: 2467 SSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSEN 2526
Query: 280 AE-----VKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQL 334
A+ +++++ L + T+ S+ + L V L + K EL +L
Sbjct: 2527 AKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNK--------------ELENKYAKL 2572
Query: 335 QEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNV--FQN 392
+EK K ED + + ++ Q++ E E V I+++ ++ L++E + +
Sbjct: 2573 EEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHA 2632
Query: 393 KIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLR 452
++ V +E ++ F +++ IA L++E ++ + ++E K EL L
Sbjct: 2633 QLKVKEEEVHRLSALFSSSQKR----IAELEEELVCVQKEAAKKVGEIEDKLKKELKHLH 2688
Query: 453 QDYARLVNELT---EKTGKLQQEEVQKKNAEQAATQ----LKVQLQEAERRWEEVQSYIR 505
D + NE E+ +L ++ V+ + T+ L Q+Q R +Q+
Sbjct: 2689 HDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQN--- 2745
Query: 506 KRTAEHEAAQQD-LQSKFVAKENEV-----QSLHSKLTDTLVSKQQL------EQRLMQL 553
+ +H + D L+ K+ A E+ Q L ++ D L+S+ E L L
Sbjct: 2746 --SRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHL 2803
Query: 554 MESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAA-QTSASVLAEELHKVI-AE 611
+ Q+ ++K+E Q+ + Q E Q+Q F +A+ Q L EL K +E
Sbjct: 2804 EKLNQQLLSKDE----QLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSE 2859
Query: 612 KDKQ---------------IKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKL-- 654
+ KQ +K+ SL ++RDRL +ELK++Q + E+ +L
Sbjct: 2860 EGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLL---KELKNLQQQYLQINQEITELHP 2916
Query: 655 -------------------QALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISN 695
+ L E + HEL +++ + R ++EQ IS+
Sbjct: 2917 LKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISD 2976
Query: 696 KMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLET-- 753
K ++ L + + L+S + Q L + + E + + L ELL T
Sbjct: 2977 KDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSAS--PDGSQNLVYETELLRTQL 3034
Query: 754 --GLIQVATKEEELNAIRTENSSLTKEVQDLKAKQND-QVSFASLVEELKKVIHEKDGKI 810
L ++ KE + + + S L +E L + D S + +++
Sbjct: 3035 NDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLE 3094
Query: 811 KSVEEL----LEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQ 866
K V+EL L ++ A +EK K + + L+E + + Q + +V EL+
Sbjct: 3095 KQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELR 3154
Query: 867 NLLKGKEEQMNTMKAVLEEKEKDL 890
LL+ + +Q + L E+ +
Sbjct: 3155 KLLEEERDQRVAAENALSVAEEQI 3178
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 171 bits (434), Expect = 3e-42
Identities = 240/1167 (20%), Positives = 506/1167 (43%), Gaps = 154/1167 (13%)
Query: 180 KVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDN 239
K++ L+ ++R++ + +E +K+ +++++ E V L+ + L
Sbjct: 835 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVS--LLQEKNDLQLQVQ 892
Query: 240 ADSSPVVDKREVIDLLKPD--QVEGIQKSGTKKLKTETDKENAEV-----KFKDFLLSLK 292
A+ + D E D L + Q+E K ++L+ E ++ NAE+ K +D LK
Sbjct: 893 AEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDE-EEMNAELTAKKRKLEDECSELK 951
Query: 293 TMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATK 352
+ +D L + + KEK +++ ++ L ++ D+++A + ++ A +
Sbjct: 952 RDI--DDLELTLAKVEKEKH---------ATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1000
Query: 353 DRCKQLTQEMMTEKERSNVVIT-------RMKDRIGTLEKEHNV------FQNKIHVSYQ 399
+ +Q ++ E+++ N + ++ D G+LE+E V + K+ +
Sbjct: 1001 EAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1060
Query: 400 ETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLV 459
TQ+ M + ++Q++ + E L + + E ++L K ++ +
Sbjct: 1061 LTQESIMDLENDKQQLDERLKKKDFELNALNARIED-----EQALGSQLQKKLKELQARI 1115
Query: 460 NELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYI-------RKRTAEHE 512
EL E+ L+ E + E+ + L +L+E R EE +KR AE +
Sbjct: 1116 EELEEE---LEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQ 1172
Query: 513 AAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQ 572
++DL+ + E +L K D++ +L +++ L +QK ++ ++++
Sbjct: 1173 KMRRDLEEATLQHEATAAALRKKHADSVA---ELGEQIDNLQRVKQKLEKEKSEFKLELD 1229
Query: 573 DI---LEQNEALKAQIQQF----------HSQIAAQTSASV--LAEELHKVIAEKDKQIK 617
D+ +EQ KA +++ H A +T SV L + K+ E + +
Sbjct: 1230 DVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSR 1289
Query: 618 QTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYV 677
Q ++ A K + ++++ L+ EV+ ALA+ +A H+ +
Sbjct: 1290 QLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCD-------- 1341
Query: 678 KDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCI 737
LL EQ + E K E ++L+ N + K +T ++ E++E+
Sbjct: 1342 ------LLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQR-----TEELEEAK 1390
Query: 738 QEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK----QNDQVSFA 793
++ ++L+ EE +E + ++ E+ + ++ E L +V+ A Q +F
Sbjct: 1391 KKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFD 1450
Query: 794 SLVEELKKVIHEKDGKIKSVEE---LLEAELLKVANK-EKTVQDL---KQEIKALKEEIG 846
++ E K+ E +++S ++ L EL K+ N E++++ L K+E K L+EEI
Sbjct: 1451 KILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEIS 1510
Query: 847 NVQLEKAQQLSITSK-VQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENE 905
++ +QL + K + EL+ + K E + +++ LEE E L + + Q E
Sbjct: 1511 DL----TEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFN 1566
Query: 906 SLKAHVQEVAQHNLKEASSASQFE---------ELEIVLKEKENEL---KRLEAMLKERE 953
+KA ++ +E A + L+ + + L K++E L E E
Sbjct: 1567 QIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEME 1626
Query: 954 SDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWN 1013
LS ++ + Q + K +S LK Q + +++L + I+ E+ + L
Sbjct: 1627 IQLSHANRMAAEAQKQVKSLQSL---LKDTQIQLDDAVRANDDLKENIAIVERRNNLLQA 1683
Query: 1014 ELDSLKDAVEHQRKKNNERQQQV----EAVELEAKEVLKKLFPKVSVPSNLSYGEW---- 1065
EL+ L+ VE + +Q++ E V+L + + K + ++LS +
Sbjct: 1684 ELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEE 1743
Query: 1066 ----LHGFEKKAKECMAGTSG-SEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGI 1120
E+KAK+ + + +EE+K + + M ++ + + L E E I
Sbjct: 1744 AVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQI 1803
Query: 1121 --------LQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSE-NKDIE 1171
LQKL+ V + EN+ + + + +++K M+ SE+ ++ L + +D +
Sbjct: 1804 ALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMR----KSERRIKELTYQTEEDRK 1859
Query: 1172 NLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQ 1231
NL R L+ ++K +++ Y + E + Q N L+K R KV +L +A++
Sbjct: 1860 NLLR----LQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFR-------KVQHELDEAEE 1908
Query: 1232 SLELIQSKIVKAAGDTTVIENSDVSPE 1258
++ +S++ K + I ++ E
Sbjct: 1909 RADIAESQVNKLRAKSRDIGTKGLNEE 1935
Score = 130 bits (326), Expect = 1e-29
Identities = 182/876 (20%), Positives = 375/876 (42%), Gaps = 109/876 (12%)
Query: 472 EEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQS 531
EE++ + + T+++ Q + R E + + +R Q ++++ K
Sbjct: 774 EEMRDERLSRIITRIQAQSRGVLARMEYKK--LLERRDSLLVIQWNIRAFMGVKNWPWMK 831
Query: 532 LHSKLTDTLVSKQQ------LEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQI 585
L+ K+ L S ++ +++ +L E+ +K + + L+ ++ +L++ L+ Q+
Sbjct: 832 LYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQV 891
Query: 586 QQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERD---RLTSKEEEL----- 637
Q +A A ++L K + + ++K+ + L E + LT+K+ +L
Sbjct: 892 QAEQDNLA---DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECS 948
Query: 638 ---KDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEIS 694
+DI ++ L ++ A N+ E+ + + + + + L+E Q +
Sbjct: 949 ELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD 1008
Query: 695 NKMEEFKILNDQNKA---LKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELL 751
+ E +N KA L+ +V L+ + ++ K V +E+ ++ + LK +E +
Sbjct: 1009 DLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQE--KKVRMDLERAKRKLEGDLKLTQESI 1066
Query: 752 ETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIK 811
+E L E ++L ++D +A L +L+K + E +I+
Sbjct: 1067 MDLENDKQQLDERLKKKDFELNALNARIEDEQA----------LGSQLQKKLKELQARIE 1116
Query: 812 SVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQ-ELQNLLK 870
+EE LEAE A EK DL +E++ + E + + Q+ + K + E Q + +
Sbjct: 1117 ELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRR 1176
Query: 871 GKEE---QMNTMKAVLEEKEKD-LANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSAS 926
EE Q A L +K D +A G+ + +LQ + L+ +E ++ L+ S
Sbjct: 1177 DLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLE---KEKSEFKLELDDVTS 1233
Query: 927 QFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQ 986
E+ ++K K N LE M + E ++ ++ Q SQ +L+ +N +
Sbjct: 1234 NMEQ---IIKAKAN----LEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGE 1286
Query: 987 QASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAV------- 1039
+ E L+ ++ + + +L+ LK +E + K N +++
Sbjct: 1287 LSRQLDEKEALISQLTRGKLTYT---QQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 1040 ------ELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEV-KVLEHK 1092
E EAK L+++ K +N +W +E A + T EE K L +
Sbjct: 1344 REQYEEETEAKAELQRVLSK----ANSEVAQWRTKYETDA---IQRTEELEEAKKKLAQR 1396
Query: 1093 LKEADEMHTLLQLEC---EKYK--------SVLAETE------GILQKLQRSVEQEENKW 1135
L+EA+E + +C EK K ++ + E L K QR+ ++ +W
Sbjct: 1397 LQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEW 1456
Query: 1136 KVKVDESHKTIKQMQSSFTSSEQELERLRSENKD----IENLRREREHLEMELEKAEMER 1191
K K +ES ++ Q S EL +L++ ++ +E +RE ++L+ E+ +
Sbjct: 1457 KQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQL 1516
Query: 1192 STYVTEVRELKAQLNETLTKLRTE-QNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVI 1250
+ + EL+ K+R + + E+ ++ L +A+ SLE + KI++A + I
Sbjct: 1517 GSSGKTIHELE--------KVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQI 1568
Query: 1251 ENSDVSPETESSEKETMSVSLN--QTVTQLQQLLQA 1284
+ +++ + ++E N + V LQ L A
Sbjct: 1569 K-AEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDA 1603
Score = 119 bits (299), Expect = 1e-26
Identities = 238/1206 (19%), Positives = 510/1206 (42%), Gaps = 166/1206 (13%)
Query: 26 WLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFK 85
W +MK + L K +K + + ++ K+ +K E + L E +
Sbjct: 827 WPWMKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKND 886
Query: 86 LSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEP 145
L + E D +A + + + + K K+ LE++ ++ + K +
Sbjct: 887 LQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE 946
Query: 146 VPVTKQPTPPSEAAASK----KKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETK 201
K+ E +K K + K KN +++ E + +K ++AL QE
Sbjct: 947 CSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKAL---QEAH 1003
Query: 202 QESGSGKKKASSKKQKTENVFVDEPLIHATTYIPL-----MDNADSSPVVDKREVIDLLK 256
Q Q +++ +E ++ T + +D+ + S +K+ +DL +
Sbjct: 1004 Q-------------QALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLER 1050
Query: 257 PDQ-VEGIQKSGTKKLKT-ETDKENAE--VKFKDFLLSLKTMMFSEDEALC--VVDLLKE 310
+ +EG K + + E DK+ + +K KDF L+ +++AL + LKE
Sbjct: 1051 AKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKE 1110
Query: 311 KSGVIQDA-----LKKSSKGELTTLIHQL-QEKDKLLAAVKEDAAATKDRCKQLTQEMMT 364
I++ +++++ ++ L L +E +++ ++E AT Q M
Sbjct: 1111 LQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATS------VQIEMN 1164
Query: 365 EKERSNVVITRMKDRIGTLEKEHNV--FQNKIHVSYQETQQMQMKFQQVREQMEAEIAHL 422
+K + R TL+ E + K S E + Q+V++++E E +
Sbjct: 1165 KKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEF 1224
Query: 423 KQENGILRDAVSNTTNQLESKQSAE---------LNKLR---QDYARLVNELTEKTGKLQ 470
K E L D SN +++K + E +N+ R ++ R VN+LT + KLQ
Sbjct: 1225 KLE---LDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQ 1281
Query: 471 QEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQ 530
E +L QL E E ++ T + E ++ L+ + AK
Sbjct: 1282 TEN----------GELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAH 1331
Query: 531 SLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHS 590
+L S D + ++Q E+ E + ++Q +L + +++ Q+ +
Sbjct: 1332 ALQSARHDCDLLREQYEE---------------ETEAKAELQRVLSK---ANSEVAQWRT 1373
Query: 591 QIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAE 650
+ +T A EEL + + +++++ E+++ + + +S E+ +QN E
Sbjct: 1374 KY--ETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQN-------E 1424
Query: 651 VQKLQALANEQAAAAHELEKMQQSVYVKDDKI----RLLEEQLQHEISNKMEEFKILNDQ 706
++ L AAA L+K Q++ DKI + E+ Q E+ + +E + L+ +
Sbjct: 1425 IEDLMVDVERSNAAAAALDKKQRNF----DKILAEWKQKYEESQSELESSQKEARSLSTE 1480
Query: 707 ----NKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKE 762
A + ++ L+T E NK++ E++ ++ KT+ EL + A K
Sbjct: 1481 LFKLKNAYEESLEHLETFKRE--NKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKM 1538
Query: 763 EELNAIRTENSSLT-KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKS-------VE 814
E +A+ +SL +E + L+A Q+ F + E+++ + EKD +++ V
Sbjct: 1539 ELQSALEEAEASLEHEEGKILRA----QLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVV 1594
Query: 815 ELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITS--KVQELQNLLKGK 872
+ L+ L +K++++ E+ +QL A +++ + +V+ LQ+LLK
Sbjct: 1595 DSLQTSLDAETRSRNEALRVKKKMEGDLNEM-EIQLSHANRMAAEAQKQVKSLQSLLKDT 1653
Query: 873 EEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQ-HNLKEASSASQFEEL 931
+ Q++ ++ ++++A + LQ E E L+A V++ + L E E +
Sbjct: 1654 QIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERV 1713
Query: 932 EIVLKEKE---NELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQA 988
+++ + N+ K+++A L + ++++ Q ++ +++ K + +
Sbjct: 1714 QLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMA------- 1766
Query: 989 SSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELE-AKEVL 1047
EEL ++E++ S L+ +K +E K R + E + L+ K+ L
Sbjct: 1767 ------EEL-----KKEQDTSA---HLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQL 1812
Query: 1048 KKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLEC 1107
+KL +V N L +K+ E + G SE ++ E + ++ LL+L+
Sbjct: 1813 QKLEARVRELEN-----ELEAEQKRNAESVKGMRKSER-RIKELTYQTEEDRKNLLRLQ- 1865
Query: 1108 EKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKT---IKQMQSSFTSSEQELERLR 1164
++ + + ++ +R E+ E + + + K + + + +E ++ +LR
Sbjct: 1866 ----DLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLR 1921
Query: 1165 SENKDI 1170
++++DI
Sbjct: 1922 AKSRDI 1927
Score = 105 bits (261), Expect = 4e-22
Identities = 172/849 (20%), Positives = 362/849 (42%), Gaps = 135/849 (15%)
Query: 107 TSSSVRERKKKE---KKQKPVLEEQVIK-ESDASKIPGKKVEPVPVTKQPTPPSEAAASK 162
TS + KK+E +K + LEE ++ E+ A+ + K + V + + K
Sbjct: 1157 TSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQK 1216
Query: 163 KKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVF 222
+ + + K DD +E ++ K + L T ++ + + + + Q++ N
Sbjct: 1217 LEKEKSEFKLELDDVTSNMEQII---KAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDL 1273
Query: 223 VDEPLIHATTYIPLMDNADSSPVVDKREVI-------DLLKPDQVEGIQKSGTKKLKTET 275
+ T +N + S +D++E + L Q+E +++ +++K +
Sbjct: 1274 TSQRAKLQT------ENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKN 1327
Query: 276 DKENAEVKFKDFLLSLKTMMFSEDEALCVVD--LLKEKSGVIQ-------DALKKSSKGE 326
+A + L+ E EA + L K S V Q DA++++ + E
Sbjct: 1328 ALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELE 1387
Query: 327 LTT--LIHQLQEKDKLLAAVKEDAAA---TKDRCKQLTQEMMTEKERSNVVITRMKDRIG 381
L +LQE ++ + AV ++ TK R + +++M + ERSN + +
Sbjct: 1388 EAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR 1447
Query: 382 TLEK-------EHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHL---KQENGILRD 431
+K ++ Q+++ S +E + + + +++ E + HL K+EN L++
Sbjct: 1448 NFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQE 1507
Query: 432 AVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQ 491
+S+ T QL S + ++EL + +L+ E+++ ++A L+
Sbjct: 1508 EISDLTEQLGSS------------GKTIHELEKVRKQLEAEKMELQSA----------LE 1545
Query: 492 EAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSL---HSKLTDTLVSKQQLEQ 548
EAE E + I + E + +++ K K+ E++ H ++ D+L + E
Sbjct: 1546 EAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAET 1605
Query: 549 RLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHS-QIAAQTSASVLAEELHK 607
R ++ E+L+++ + + NE +IQ H+ ++AA+ V + L
Sbjct: 1606 R------------SRNEALRVKKKMEGDLNEM---EIQLSHANRMAAEAQKQV--KSLQS 1648
Query: 608 VIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHE 667
++ KD QI Q +D++ + D +E + ++ N LL+AE+++L+A+ EQ + +
Sbjct: 1649 LL--KDTQI-QLDDAVRANDDL----KENIAIVERRNNLLQAELEELRAVV-EQTERSRK 1700
Query: 668 LEKMQQSVYVKDDKIRLLEEQ-----------------LQHEISNKMEEFKILNDQ-NKA 709
L +Q + ++++LL Q LQ E+ ++E + ++ KA
Sbjct: 1701 LA--EQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKA 1758
Query: 710 LKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIR 769
+ + L EQ +E+M+K +++ T+++L Q E E A++
Sbjct: 1759 ITDAAMMAEELKKEQDTSAHLERMKKNMEQ------TIKDL------QHRLDEAEQIALK 1806
Query: 770 TENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEK 829
L K ++ +N+ + E K + + + +IK + E + + +
Sbjct: 1807 GGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQD 1866
Query: 830 TVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQ----ELQNLLKGKEEQMNTMKAVLEE 885
V L+ ++KA K + + + LS KVQ E + E Q+N ++A
Sbjct: 1867 LVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRA---- 1922
Query: 886 KEKDLANTG 894
K +D+ G
Sbjct: 1923 KSRDIGTKG 1931
Score = 35.8 bits (81), Expect = 0.27
Identities = 43/224 (19%), Positives = 99/224 (44%), Gaps = 17/224 (7%)
Query: 1085 EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQR---SVEQEENKWKVKVDE 1141
++K L + EM ++ + E + K L ++E ++L+ S+ QE+N +++V
Sbjct: 835 KIKPLLKSAEREKEMASMKE-EFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA 893
Query: 1142 SHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMEL--EKAEMERSTYVTEVR 1199
+ + + +L ++ K++ + E + EL +K ++E E
Sbjct: 894 EQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE-----DECS 948
Query: 1200 ELKAQLNE---TLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVS 1256
ELK +++ TL K+ E++ + +L + L+ I +K+ K + ++ +
Sbjct: 949 ELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTK---EKKALQEAHQQ 1005
Query: 1257 PETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
+ +E +L + +L+Q + + L +EK+ LE
Sbjct: 1006 ALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLE 1049
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 170 bits (430), Expect = 9e-42
Identities = 248/1126 (22%), Positives = 497/1126 (44%), Gaps = 162/1126 (14%)
Query: 261 EGIQKSGTKKLKTE---TDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQD 317
E + K K+L E T+ E + + L L+ + +E E + L+
Sbjct: 852 EELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELR-------- 903
Query: 318 ALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMK 377
A + K EL + H L+ A V+E+ ++RC Q + EK++ I ++
Sbjct: 904 ARLTAKKQELEEICHDLE------ARVEEE----EERC----QHLQAEKKKMQQNIQELE 949
Query: 378 DRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTT 437
++ LE+E + Q K+ + T+ K ++ + +E + L +E +L D ++ T
Sbjct: 950 EQ---LEEEESARQ-KLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFT 1005
Query: 438 NQL--ESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQA-------ATQLKV 488
L E ++S L KL+ + ++ +L E+ L++EE Q++ E+ +T L
Sbjct: 1006 TNLTEEEEKSKSLAKLKNKHEAMITDLEER---LRREEKQRQELEKTRRKLEGDSTDLSD 1062
Query: 489 QLQEAERRWEEVQSYIRKRTAEHEAA----------------------------QQDLQS 520
Q+ E + + E++ + K+ E +AA Q+DL+S
Sbjct: 1063 QIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLES 1122
Query: 521 KFVAKENEVQSLHSKLTDTLVS-KQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNE 579
+ A N+ + L + L + K +LE L ++ R +E+ + + + + E+ +
Sbjct: 1123 E-RASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAK 1181
Query: 580 ALKAQIQ---QFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEE 636
+AQIQ Q HSQ + LAE+L + K +++ + +L +ER L ++ +
Sbjct: 1182 THEAQIQEMRQKHSQAVEE-----LAEQLEQTKRVK-ANLEKAKQTLENERGELANEVKV 1235
Query: 637 L----KDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHE 692
L D ++ ++A++Q+LQ NE EL + V+ D + L Q +
Sbjct: 1236 LLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSK 1295
Query: 693 ISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLE 752
S ++F AL+S++Q Q L+ E+ N+ + K Q +DEK E+L E
Sbjct: 1296 SSKLTKDF-------SALESQLQDTQELLQEE-NRQKLSLSTKLKQVEDEKNSFREQLEE 1347
Query: 753 TGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKS 812
+EE + + + ++L +V D+K K D V EE+K+ + +KD ++
Sbjct: 1348 --------EEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKL-QKD--LEG 1396
Query: 813 VEELLEAELLKVANKEKTVQDLKQEIKALKEEIGN-----VQLEK---------AQQLSI 858
+ + E ++ EKT L+QE+ L ++ + LEK A++ +I
Sbjct: 1397 LSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTI 1456
Query: 859 TSKVQELQNLLKG----KEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEV 914
++K E ++ + KE + ++ LEE + A + + + E E L + +V
Sbjct: 1457 SAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDV 1516
Query: 915 AQ--HNLKEASSA--SQFEELEIVLKEKENELKRLEAMLKERESDLSS-KTQLLQDVQDE 969
+ H L+++ A Q EE++ L+E E+EL+ E E +L + K Q +D+Q
Sbjct: 1517 GKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGR 1576
Query: 970 NKLFKSQIEQL-KQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKK 1028
++ + + +QL +Q +A ++ ++ R+K L +L L+ ++ K
Sbjct: 1577 DEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKK----LEMDLKDLEAHIDSANKN 1632
Query: 1029 NNERQQQVEAVELEAKEVLKKL-FPKVSVPSNLSYGEWLHGFEKKAKECMAG-TSGSEEV 1086
+E +Q+ ++ + K+ +++L + S L+ + EKK K A EE+
Sbjct: 1633 RDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAK---ENEKKLKSMEAEMIQLQEEL 1689
Query: 1087 KVLEHKLKEADEMHTLL--QLECEKYKSVLA-----ETEGILQKLQRSVEQEENKWKVKV 1139
E ++A + L ++ K LA E + +L+ +E+E+ ++
Sbjct: 1690 AAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELIN 1749
Query: 1140 DESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEME---RSTYVT 1196
D K +Q +++ LER ++ + + ER++ E++++ EME +S Y
Sbjct: 1750 DRLKKA--NLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKA 1807
Query: 1197 EVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLE--LIQSKIVKAAGDTTVIENSD 1254
+ L+A++ + +L E ERQ + + ++ L+ L+Q +++
Sbjct: 1808 SITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQ------------VDDER 1855
Query: 1255 VSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
+ E + + S L Q QL++ + + ++ + LE
Sbjct: 1856 RNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELE 1901
Score = 140 bits (354), Expect = 6e-33
Identities = 178/794 (22%), Positives = 352/794 (44%), Gaps = 94/794 (11%)
Query: 550 LMQLMESEQKRVNKEESL------QMQVQDILEQNEALKAQIQ----QFHSQIAAQTSAS 599
L+Q+ E++ + KEE L Q+ ++ L + E L++Q+ Q Q+ A+T
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELC 896
Query: 600 VLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALAN 659
AEEL + K +++++ L + R+ +EE + +Q ++ +Q+L+
Sbjct: 897 AEAEELRARLTAKKQELEEICHDLEA---RVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953
Query: 660 EQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQT 719
E+ +A +K+Q + K++ LE EE IL DQN L E + L+
Sbjct: 954 EEESAR---QKLQLEKVTTEAKLKKLE-----------EEQIILEDQNCKLAKEKKLLED 999
Query: 720 LVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEE----ELNAIRT----E 771
++E ++ E+ EK + KLK E + T L + +EE EL R +
Sbjct: 1000 RIAEF-TTNLTEEEEK--SKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGD 1056
Query: 772 NSSLTKEVQDLKAKQND-QVSFASLVEELK-----------------KVIHEKDGKIKSV 813
++ L+ ++ +L+A+ + ++ A EEL+ K I E + +I +
Sbjct: 1057 STDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISEL 1116
Query: 814 EELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGK- 872
+E LE+E EK +DL +E++ALK E+ + A Q + SK ++ N+LK
Sbjct: 1117 QEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTL 1176
Query: 873 EEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELE 932
EE+ T +A ++E + + + L + E+ + +KA++++ Q E + E++
Sbjct: 1177 EEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELA--NEVK 1234
Query: 933 IVLKEK---ENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQAS 989
++L+ K E++ K++EA L+E + + ++ ++ D K+ K Q+E S
Sbjct: 1235 VLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELAD--KVTKLQVELDNVTGLLSQS 1292
Query: 990 SFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKK 1049
S+ K+ S L ++L ++ ++ + ++ +++ VE E ++
Sbjct: 1293 D--------SKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQ 1344
Query: 1050 LFPKVSVPSNLSYG-EWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECE 1108
L + NL LH K+ M + G L+ A+E+ LQ + E
Sbjct: 1345 LEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGC---------LETAEEVKRKLQKDLE 1395
Query: 1109 KYKSVLAETEGILQKLQRS---VEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRS 1165
E KL+++ ++QE + V +D +Q + +++ ++L +
Sbjct: 1396 GLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQ----RQSACNLEKKQKKFDQLLA 1451
Query: 1166 ENKDIE-NLRREREHLEMELEKAE---MERSTYVTEVRELKAQLNETLTKLRTEQNERQK 1221
E K I ER+ E E + E + + + E E KA+L + RTE +
Sbjct: 1452 EEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMS 1511
Query: 1222 VAGDLHKAQQSLELIQSKIVKAAGD-TTVIENSDVSPETESSEKETMSVSLNQTVTQLQQ 1280
D+ K+ LE + + + + T +E + + K + V+L Q ++
Sbjct: 1512 SKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFER 1571
Query: 1281 LLQAVNQQLTKEKE 1294
LQ ++Q ++K+
Sbjct: 1572 DLQGRDEQSEEKKK 1585
Score = 127 bits (320), Expect = 5e-29
Identities = 220/1084 (20%), Positives = 456/1084 (42%), Gaps = 169/1084 (15%)
Query: 105 VETSSSVRERKKKEK-----KQKPVLEEQVIKESDASKIPG-KKVEPVPVTKQPTPPSEA 158
+E S R++ + EK K K + EEQ+I E K+ KK+ + + T +E
Sbjct: 952 LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE 1011
Query: 159 AASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGS-----GKKKASS 213
K + K+K+ + D + +RQE ++ + +S + +A
Sbjct: 1012 EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071
Query: 214 KKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKT 273
+ K + +E L A + + A + + K ++ + E ++ + K
Sbjct: 1072 AELKMQLAKKEEELQAALARVE-EEAAQKNMALKKIRELESQISELQEDLESERASRNKA 1130
Query: 274 ETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQ 333
E K + + L +LKT + ++ L+ K + LKK+ + E T Q
Sbjct: 1131 EKQKRD----LGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQ 1186
Query: 334 LQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNK 393
+QE + + Q +E+ + E++ V ++ TLE E N+
Sbjct: 1187 IQEM--------------RQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANE 1232
Query: 394 IHVSYQ--------------ETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQ 439
+ V Q + Q++Q+KF + E++ E+A + + D V+ +Q
Sbjct: 1233 VKVLLQGKGDSEHKRKKVEAQLQELQVKFNE-GERVRTELADKVTKLQVELDNVTGLLSQ 1291
Query: 440 LESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEE 499
+SK S KL +D++ L ++L + LQ+E QK + +T+LK + E+
Sbjct: 1292 SDSKSS----KLTKDFSALESQLQDTQELLQEENRQKLSL---STKLK--------QVED 1336
Query: 500 VQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVS-------KQQLEQRLMQ 552
++ R++ E E A+ +L+ + +V + K+ D++ K++L++ L
Sbjct: 1337 EKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEG 1396
Query: 553 LMESEQKRV-------NKEESLQMQVQDIL------EQNEALKAQIQQFHSQIAAQ--TS 597
L + +++V + LQ ++ D+L Q+ + Q+ Q+ A+ T
Sbjct: 1397 LSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTI 1456
Query: 598 ASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQAL 657
++ AEE + AE ++ E S L E+ +++ +N + E++ L +
Sbjct: 1457 SAKYAEERDRAEAEA----REKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSS 1512
Query: 658 ANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKL 717
++ + HELEK + R LE+Q++ E+ ++EE L D+ +A +E KL
Sbjct: 1513 KDDVGKSVHELEKSK----------RALEQQVE-EMKTQLEE---LEDELQA--TEDAKL 1556
Query: 718 QTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTK 777
+ V+ Q K Q E+ +Q +DE+ EE + L +
Sbjct: 1557 RLEVNLQAMK---AQFERDLQGRDEQ------------------SEE------KKKQLVR 1589
Query: 778 EVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQE 837
+V++++A+ D+ S+ +K + E D +K +E +++ N+++ ++ L++
Sbjct: 1590 QVREMEAELEDERKQRSMAVAARKKL-EMD--LKDLEAHIDSAN---KNRDEAIKQLRKL 1643
Query: 838 IKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWL 897
+K+ + + +A + I ++ +E E+++ +M+A + + +++LA +
Sbjct: 1644 QAQMKDCMRELDDTRASREEILAQAKE-------NEKKLKSMEAEMIQLQEELAAAERAK 1696
Query: 898 QDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLS 957
+ Q+E + L E+A + K A + + LE + + E EL+ + + L
Sbjct: 1697 RQAQQERDEL---ADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLK 1753
Query: 958 SKTQLLQDVQDENKLFKSQIE-------QLKQQNYQQASSFPPHEELLKVISEREKEISG 1010
+ + + L +S + QL++QN + E +K S+ + I+
Sbjct: 1754 KANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVK--SKYKASITA 1811
Query: 1011 LWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFE 1070
L ++ L++ ++++ K+ +QV E + K+VL + V E
Sbjct: 1812 LEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVL------LQVDDERRNAEQYKDQA 1865
Query: 1071 KKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQ 1130
KA S +K L+ +L+EA+E K + L + + R V
Sbjct: 1866 DKA---------STRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSS 1916
Query: 1131 EENK 1134
+NK
Sbjct: 1917 LKNK 1920
Score = 106 bits (265), Expect = 1e-22
Identities = 185/904 (20%), Positives = 392/904 (43%), Gaps = 96/904 (10%)
Query: 38 LAKQKREQKLIPTKTDKKKAEK----KKNKKKEIQNGNLHES-DSESVPRDF--KLSDAL 90
LAK++ E + + +++ A+K KK ++ E Q L E +SE R+ K L
Sbjct: 1078 LAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDL 1137
Query: 91 AVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVL-----EEQVIKESDASKIPGKKVEP 145
E + + + ++++++ +E + K +++ +L EE E+ ++ K +
Sbjct: 1138 GEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQA 1197
Query: 146 VPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPS-----KRQEALPLHQET 200
V + ++ + + ++ +N + +V+ L+ KR++ QE
Sbjct: 1198 VEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQEL 1257
Query: 201 KQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQV 260
+ + G++ + K + V+ + T + ++ SS + ++ D
Sbjct: 1258 QVKFNEGERVRTELADKVTKLQVE---LDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQ 1314
Query: 261 EGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDL-LKEKSGVIQDAL 319
E +Q+ +KL T + E D S + + E+EA ++ + + D
Sbjct: 1315 ELLQEENRQKLSLSTKLKQVE----DEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMK 1370
Query: 320 KK--SSKGELTT---LIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVIT 374
KK S G L T + +LQ+ + L+ E+ A D+ ++ + E + V +
Sbjct: 1371 KKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLD 1430
Query: 375 RMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVS 434
+ LEK+ F + E + + K+ + R++ EAE + + L A+
Sbjct: 1431 HQRQSACNLEKKQKKFDQLL----AEEKTISAKYAEERDRAEAEAREKETKALSLARALE 1486
Query: 435 NTTNQLESKQSAELNKLRQDYARLVNELT---EKTGKLQQE-EVQKKNAEQAATQLKVQL 490
+Q AEL +L + + + +L + GK E E K+ EQ ++K QL
Sbjct: 1487 EAM-----EQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQL 1541
Query: 491 QEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRL 550
+E E +E+Q+ E Q ++++F E ++Q + + K+QL +++
Sbjct: 1542 EELE---DELQA-TEDAKLRLEVNLQAMKAQF---ERDLQGRDEQSEE---KKKQLVRQV 1591
Query: 551 MQLMESEQKRVNKEESLQMQVQDILEQN-EALKAQIQQFHSQIAAQTSASVLAEELHKVI 609
+ ME+E + K+ S+ + + LE + + L+A I +A + ++L K+
Sbjct: 1592 RE-MEAELEDERKQRSMAVAARKKLEMDLKDLEAHID------SANKNRDEAIKQLRKLQ 1644
Query: 610 AEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELE 669
A+ +++ +D+ AS + L +E K +++M +AE+ +LQ E+ AAA +
Sbjct: 1645 AQMKDCMRELDDTRASREEILAQAKENEKKLKSM----EAEMIQLQ----EELAAAERAK 1696
Query: 670 KMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQT-LVSEQPNKD 728
+ Q ++L EI+N + + ++ + L++ + +L+ L EQ N +
Sbjct: 1697 RQAQQE----------RDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTE 1746
Query: 729 VVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQND 788
++ +++LK L+ I E +A + EN+ E Q+ + K
Sbjct: 1747 LI----------NDRLKKAN--LQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKL 1794
Query: 789 QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLK--VANKE--KTVQDLKQEIKALKEE 844
Q ++ + K I + KI +EE L+ E + A K+ +T + LK + + +E
Sbjct: 1795 QEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDE 1854
Query: 845 IGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEEN 904
N + K Q ++++++L+ L+ EE+ A + +++L + + + E
Sbjct: 1855 RRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREV 1914
Query: 905 ESLK 908
SLK
Sbjct: 1915 SSLK 1918
Score = 73.6 bits (179), Expect = 1e-12
Identities = 96/467 (20%), Positives = 199/467 (42%), Gaps = 46/467 (9%)
Query: 835 KQEIKALKEEIGN----VQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDL 890
+Q++ A+K N ++L Q + +KV+ L + + +EE M + +++ +EK L
Sbjct: 803 QQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQL 862
Query: 891 ANTGKW--LQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAM 948
A + ++ LQ + + K +QE Q E ++ EEL L K+ EL E +
Sbjct: 863 AAENRLTEMETLQSQLMAEKLQLQEQLQ---AETELCAEAEELRARLTAKKQEL---EEI 916
Query: 949 LKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEI 1008
+ E+ + + + Q +Q E K + I++L++Q ++ S+ R+K
Sbjct: 917 CHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESA-------------RQK-- 961
Query: 1009 SGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVS-VPSNLSYGEWLH 1067
L K E + KK E Q +E + + K L +++ +NL+
Sbjct: 962 ------LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTE----- 1010
Query: 1068 GFEKKAKECMAGTSGSEEVKV--LEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQ 1125
E++ + +A E + LE +L+ ++ L+ K + + + +LQ
Sbjct: 1011 --EEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQ 1068
Query: 1126 RSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELE 1185
+ + + + K +E + +++ L+++R I L+ + E
Sbjct: 1069 AQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRN 1128
Query: 1186 KAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAG 1245
KAE ++ E+ LK +L +TL +Q R K +++ +++LE ++K +A
Sbjct: 1129 KAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLE-EEAKTHEAQI 1187
Query: 1246 DTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKE 1292
++S E ++T V N + + +Q L+ +L E
Sbjct: 1188 QEMRQKHSQAVEELAEQLEQTKRVKAN--LEKAKQTLENERGELANE 1232
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 167 bits (422), Expect = 8e-41
Identities = 312/1440 (21%), Positives = 610/1440 (42%), Gaps = 234/1440 (16%)
Query: 29 MKETLY--DEVLAKQKREQKLIPTKTDKKKAEKKKNKK---KEIQNGNLHESDSESVPRD 83
M ETL +E +A+ + K + T+ ++ + +K+K+++ +E++ +E R
Sbjct: 373 MHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRK 432
Query: 84 FKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPG-KK 142
K A D+Q+ + E S+++ + K++ V+K+S +I +K
Sbjct: 433 LK-----AEMDEQIKTIEKTSEEERISLQQELSRVKQEVV----DVMKKSSEEQIAKLQK 483
Query: 143 VEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQ 202
+ + ++ ++ ++++ Q++ K + + + ++QE+L L + Q
Sbjct: 484 LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQ 543
Query: 203 ESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEG 262
KK ++ + E + T + L + + S +K + DL
Sbjct: 544 -----KKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDL-------- 590
Query: 263 IQKSGTKKLKTETDKENAEV-----KFKDFLLSLKTMMFSEDEALCV--VDLLKEKSGVI 315
L+ E +K N E+ K K L SLK + +AL + +LK++
Sbjct: 591 -----AVHLEAEKNKHNKEITVMVEKHKTELESLK----HQQDALWTEKLQVLKQQYQTE 641
Query: 316 QDALKKSSKGELTTLIHQLQEKDKLLAA-VKEDAAATKDRC--KQLTQEMMTEKERSNVV 372
+ L++ + E TL L++K+ + A ++E T ++ KQ E ++ E S V+
Sbjct: 642 MEKLREKCEQEKETL---LKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSS-ELSEVL 697
Query: 373 ITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRD- 431
R K LE+E +V +++ QE + +M Q+ Q + + + E I R
Sbjct: 698 KARHK-----LEEELSVLKDQTDKMKQELEA-KMDEQKNHHQQQVDSIIKEHEVSIQRTE 751
Query: 432 -AVSNTTNQLE----------SKQSAELNKLRQDYARLVNELTEKTGKLQQ-EEVQKKNA 479
A+ + NQLE + A + L D R EL + + KL + Q
Sbjct: 752 KALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATH 811
Query: 480 EQ--AATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLT 537
EQ A + QLQ+ E + + K+ AE EA ++D+ ++ A + +VQ L +L
Sbjct: 812 EQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLE 871
Query: 538 DTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQV-----QDILEQNEALKAQIQQFHSQI 592
+Q + L Q+ ES+ + NKE+ Q+ IL+ E K +I+ ++
Sbjct: 872 KQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKL 931
Query: 593 AA-QTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSK----EEEL-KDIQNMNFL 646
+A + S +L EE ++K++++ + ++ L K E +L K+++N
Sbjct: 932 SAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALE 991
Query: 647 LKAEVQKLQA--LANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEF-KIL 703
L + ++ A L QA +A + + + + ++I L E + E+++ + + K L
Sbjct: 992 LSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKL 1051
Query: 704 NDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQ---EKDEKLKTVEELLETGLIQVAT 760
N Q E+Q++ + ++ ++V E +K + EK+E K + L E G+ Q T
Sbjct: 1052 NQQ----AEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTT 1107
Query: 761 ---KEEELNAIRTENSSLTKEVQDLKAK------------------QNDQVSFASLVEEL 799
+E+L +SL ++ LKA Q V L EE
Sbjct: 1108 LNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEED 1167
Query: 800 KKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLE-------- 851
K+ + E K+K+ +E ++ K+++D E K L EE+ +QL+
Sbjct: 1168 KRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELA-IQLDICCKKTEA 1226
Query: 852 ----------------------------------KAQQLSITSKVQELQNLLKGKEEQMN 877
K L T V EL+ L+ E+ N
Sbjct: 1227 LLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQN 1286
Query: 878 TMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFE----ELEI 933
T+ ++ L ++ ++ + ESL + + + + +AS+ E +L+
Sbjct: 1287 TLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKK 1346
Query: 934 VLKEKENELKRLEAMLKERESDLSSKTQLLQD--VQDENKLFKSQ----IEQLKQQNYQQ 987
L E N + ++ LKE++ ++SS ++ L D VQ +N + S+ I L++Q ++
Sbjct: 1347 ELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEE 1406
Query: 988 ASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVL 1047
ELL + + ++ L E S + V+ K +E +++ ++ + + +
Sbjct: 1407 KC------ELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTV 1460
Query: 1048 KKLFPKVSVPSNLSY--GEWLH------GFEKKAKECMAGTSGSEEVKV------LEHKL 1093
K+L ++ + S +Y E ++ + K +C+ G ++ K+ LE +L
Sbjct: 1461 KELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETEL 1520
Query: 1094 K-------EADEMHTLLQLECEKYKSVL--------AETEGILQKLQRSVEQEENKWKVK 1138
K E ++ T +E E VL E + ++QKLQ E E K +
Sbjct: 1521 KSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEK-DNR 1579
Query: 1139 VDESHKTIKQMQSSFTSSEQELERLRSE----NKDIENLRREREHLEMELEK------AE 1188
V E+ + I +++ S + ELE + E N +++ E + LE LE AE
Sbjct: 1580 VKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAE 1639
Query: 1189 MERST---YVTEVRELKAQLNET-----------LTKLRTEQNERQKVAGDLHKAQQSLE 1234
++R ++L +Q+ E L++L T+ ER++ L + +S+E
Sbjct: 1640 LKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVE 1699
Query: 1235 LIQSKIV------KAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQ 1288
QS+ + K T E +D + + +E +SV L + +T+ ++LLQ V Q+
Sbjct: 1700 SSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISV-LQRNLTEKEKLLQRVGQE 1758
Score = 163 bits (413), Expect = 9e-40
Identities = 294/1392 (21%), Positives = 589/1392 (42%), Gaps = 250/1392 (17%)
Query: 74 ESDSESVPRD---FKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVI 130
ESD E V D K + L + + ET S +E+ +K L+EQ+
Sbjct: 265 ESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLD 324
Query: 131 KE-SDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSK 189
+ + KI K + TK T +A ++ Q K ++ + + ETL + K
Sbjct: 325 ERLQELEKI--KDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEM--K 380
Query: 190 RQEALPLHQETKQESGSGKK-----------------KASSKKQKTENVF------VDEP 226
+E L KQ + G++ KA S QKTE +DE
Sbjct: 381 EEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQ 440
Query: 227 L--IHATTYIPLMDNADSSPVVDKREVIDLLKP---DQVEGIQKSGTKKL--KTETDKEN 279
+ I T+ + V K+EV+D++K +Q+ +QK K+L K + +
Sbjct: 441 IKTIEKTSEEERISLQQELSRV-KQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKK 499
Query: 280 AEVKFKDFLLSLKTMMF-SEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKD 338
+ + ++F +K + S+ E L + +++ + + L+ K LT ++L++
Sbjct: 500 LQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQ 559
Query: 339 K-----------LLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRM----KDRIGTL 383
+ L +++++ K++ K L + EK + N IT M K + +L
Sbjct: 560 QEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESL 619
Query: 384 EKEHN-VFQNKIHVSYQETQQMQMKFQQVREQMEAEI------------AHLKQENGILR 430
+ + + ++ K+ V QQ Q + +++RE+ E E AH+++ N
Sbjct: 620 KHQQDALWTEKLQVL---KQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTL 676
Query: 431 DAVSNTTNQLESKQS--AELNKLRQDYARLVNELTEKTGKLQQE-----EVQKKNAEQAA 483
+ + +LES S +E+ K R ++ L ++T K++QE + QK + +Q
Sbjct: 677 EKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQV 736
Query: 484 TQL----KVQLQEAERRWEEVQSYIR-------KRTAEHEAAQQDLQSKFVAKENEVQSL 532
+ +V +Q E+ ++ + + K EH+A ++L++ E E+Q
Sbjct: 737 DSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQA 796
Query: 533 HSKLT-----------DTLVSKQQLEQRLMQLMESEQKRV---NKEESLQMQVQDILEQN 578
+KL T ++QL Q +L++ E +R+ + ++ Q +D+ +
Sbjct: 797 SAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTEL 856
Query: 579 EALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELK 638
+A K Q+Q Q+ Q S E ++++K S+ + ++E+ K
Sbjct: 857 DAHKIQVQDLMQQLEKQNS-------------EMEQKVKSLTQVYESKLEDGNKEQEQTK 903
Query: 639 DIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKME 698
I V+K + + E+E + Q + K+D I +L E+ + + N
Sbjct: 904 QIL---------VEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKN--- 951
Query: 699 EFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQV 758
Q K ++ QK K++ E ++K + +++ KLK + LE +++
Sbjct: 952 -------QEKKMEKVKQKA---------KEMQETLKKKLLDQEAKLK---KELENTALEL 992
Query: 759 ATKEEELNAIRTE-----NSSLTKEVQDLKAKQNDQVSFASLVE--ELKKVIHEKDGKI- 810
+ KE++ NA E ++ ++ V L+ Q +Q+ + V EL VI + K+
Sbjct: 993 SQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLN 1052
Query: 811 KSVEELLEAELLKVANKEKTVQDLKQEIKAL---KEEIGN-VQLEKAQQLSITSKVQELQ 866
+ EEL E +++ KE+ V +LKQ+I KEE+ + K + + + + ELQ
Sbjct: 1053 QQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQ 1112
Query: 867 NLLKGKEEQMNTM-------KAVLEEKEKDLANTGKWLQDLQEENESLKAHVQE----VA 915
LK K +N++ KA LE+ E DL + K LQE+ LK +E V+
Sbjct: 1113 EQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVS 1172
Query: 916 QHNLKEASSASQFEELEIV-------LKEKENELKRLEAML--------KERESDLSSKT 960
+ K ++ +F+ L+ L++K E K+L L K+ E+ L +KT
Sbjct: 1173 ELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKT 1232
Query: 961 -QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKV--ISEREKEISGLWNELDS 1017
+L+ + S+I + + + + L+K +SE E ++ L E ++
Sbjct: 1233 NELINISSSKTNAILSRISHCQHRTTKVKEAL-----LIKTCTVSELEAQLRQLTEEQNT 1287
Query: 1018 LKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECM 1077
L + + + E++ Q+++++ + + ++ EK+A +
Sbjct: 1288 LNISFQQATHQLEEKENQIKSMKADIESLVT---------------------EKEALQKE 1326
Query: 1078 AGT---SGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENK 1134
G + SE+ + KE E + L E+ K E + ++L Q +N
Sbjct: 1327 GGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNS 1386
Query: 1135 WKVKVDESHKTIKQMQSSFTSSEQEL-ERLRSENKDIENLRREREHLEMELE-------- 1185
+ + E I ++ + + EL ++++ + ++ L +E+ +++
Sbjct: 1387 --ISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSE 1444
Query: 1186 ---KAEMERSTYVTEVRELKAQLNETLTKLRTEQNER-QKVAGDLHKAQQSLELIQSKIV 1241
KA+ + + V+EL+ QL E +K E++E+ + +L + + + ++ ++
Sbjct: 1445 WKKKAQSRFTQHQNTVKELQIQL-ELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEM- 1502
Query: 1242 KAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQ-------LQQLLQAVNQQ------ 1288
D + +E + + ETE + + L +TQ L ++L+ NQQ
Sbjct: 1503 --EDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHK 1560
Query: 1289 -LTKEKEHYQVL 1299
L ++ +H+Q L
Sbjct: 1561 ELVQKLQHFQEL 1572
Score = 148 bits (373), Expect = 4e-35
Identities = 275/1331 (20%), Positives = 575/1331 (43%), Gaps = 207/1331 (15%)
Query: 35 DEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVE- 93
++ + K K++ K + KK +++ KKE++N L S E L A A
Sbjct: 953 EKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSA 1012
Query: 94 --DDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQ 151
D V+ + N E S+ E ++E + E+ + + ++++ + +
Sbjct: 1013 GISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQ------AEELQEIHEIQL 1066
Query: 152 PTPPSEAAASKKKP---GQKKSKNGSD---------DQDKKVETLMVPSKRQEALP---L 196
E A K+K G +K + + QD + L K++ A
Sbjct: 1067 QEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLA 1126
Query: 197 HQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLK 256
ETK ++ K + K EN F+ E L+ + ++ D V E+ LK
Sbjct: 1127 QDETKLKAHLEKLEVDLNKSLKENTFLQEQLVE----LKMLAEEDKRKV---SELTSKLK 1179
Query: 257 PDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQ 316
E + LK+ +K N ++ K SL+ SE+ A+ +D+ +K+
Sbjct: 1180 TTDEE------FQSLKSSHEKSNKSLEDK----SLEFKKLSEELAI-QLDICCKKT---- 1224
Query: 317 DALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATK-DRCKQLTQEMMTEKERSNVVITR 375
+AL ++ EL + ++ K +A ++ C+ T ++ ++
Sbjct: 1225 EALLEAKTNELINI-----------SSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSE 1273
Query: 376 MKDRIGTLEKEHNVFQNKIHVSYQE-TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVS 434
++ ++ L +E QN +++S+Q+ T Q++ K Q++ M+A+I L E L+
Sbjct: 1274 LEAQLRQLTEE----QNTLNISFQQATHQLEEKENQIKS-MKADIESLVTEKEALQKEGG 1328
Query: 435 NTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAE 494
N K+S + +L+++ + +N +T +L++++V+ + + T L VQLQ +
Sbjct: 1329 NQQQAASEKESC-ITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSI 1387
Query: 495 RRWEEVQ--SYIRKRTAEHEAAQ----QDL------------------------------ 518
E+ S +RK+ E + QDL
Sbjct: 1388 SLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKK 1447
Query: 519 --QSKFVAKENEVQSLHSKLTDTLVSKQQLEQ-RLMQLMESEQKRVNKE-ESLQMQVQDI 574
QS+F +N V+ L +L L SK+ E+ + L++ E + NK + L+ +++D
Sbjct: 1448 KAQSRFTQHQNTVKELQIQLE--LKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDD 1505
Query: 575 LEQNEALKAQIQ-QFHSQIAAQ-------TSASVLAEELHKVIAE--KDKQIKQTE---- 620
+ E ++ ++ + SQ A T ++ E L++V+ + K I+ E
Sbjct: 1506 KSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQK 1565
Query: 621 ----DSLASERD-RLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSV 675
L E+D R+ EE++ ++N + +KAE++ + ELE + SV
Sbjct: 1566 LQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKK----------ELEHVNLSV 1615
Query: 676 YVKDDKIRLLEEQLQHEISNKMEEFKILNDQN-KALKSEVQKLQTLVSEQPNKDV---VE 731
K+++++ LE++L+ E + K+ E K +Q A+K ++ EQ K +
Sbjct: 1616 KSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLS 1675
Query: 732 QMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVS 791
++ +QE++ ++ +EE L++ ++ + E + +N + E ++ ++ Q +
Sbjct: 1676 ELNTKLQEREREVHILEEKLKS--VESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKT 1733
Query: 792 FASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLE 851
+ + L++ + EK+ ++ V + KE+TV + +E + ++
Sbjct: 1734 YEEKISVLQRNLTEKEKLLQRVGQ----------EKEETVSSHFEMRCQYQERLIKLEHA 1783
Query: 852 KAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHV 911
+A+Q S + LQ L+ K ++ + + A EKE N + Q+L+ + ++ +
Sbjct: 1784 EAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGG-KNNIQAKQNLENVFDDVQKTL 1842
Query: 912 QE------VAQHNLKEASS--ASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLL 963
QE + + +KE S Q E + ++E ++ ++L+A+ ++ + T+LL
Sbjct: 1843 QEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQAL--QQMDGRNKPTELL 1900
Query: 964 QDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVE 1023
++ +E KS + Q K + +A H +L ++ E+E L E+ L+ +
Sbjct: 1901 EENTEEKS--KSHLVQPKLLSNMEAQ----HNDLEFKLAGAEREKQKLGKEIVRLQKDLR 1954
Query: 1024 HQRKKNNERQQQVEAV----ELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAG 1079
RK E QQ++E + + E +E +K+ + + N + + + F
Sbjct: 1955 MLRK---EHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREF---------N 2002
Query: 1080 TSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKV 1139
T +++ + LE +KE ++ ++E E +S ET +L+K+ K
Sbjct: 2003 TQLAQKEQELEMTIKET--INKAQEVEAELLESHQEETNQLLKKIAE-----------KD 2049
Query: 1140 DESHKTIKQMQSSFTSSEQEL-ERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEV 1198
D+ +T K+ + + E+E+ ++R +E L+++ + +LE+ E + VT +
Sbjct: 2050 DDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKK---YQQKLEQEENPGNDNVT-I 2105
Query: 1199 RELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTV----IENSD 1254
EL+ QL + T + + + Q+ +H + L+ + + T + ++D
Sbjct: 2106 MELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTPYKGGNLYHTD 2165
Query: 1255 VSPETESSEKE 1265
VS E +E E
Sbjct: 2166 VSLFGEPTEFE 2176
Score = 107 bits (268), Expect = 6e-23
Identities = 163/830 (19%), Positives = 349/830 (42%), Gaps = 164/830 (19%)
Query: 621 DSLASERDRLTSKEEELKDIQNMN-----------------FLLKAEVQKLQA-LANEQA 662
+ L D L +KE+ ++ ++ M +L+ E +KLQ L+ Q
Sbjct: 125 EDLVGNSDSL-NKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQD 183
Query: 663 AAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKS-------EVQ 715
+ + ++++ + + + L+E+ + K + +L Q LK V
Sbjct: 184 KSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVD 243
Query: 716 KLQTLVSEQPNKDVVEQME----------------KCIQEKDEKLKTVEELLETGLIQVA 759
L+ L +P +V + E K ++ +++K E LL+ +
Sbjct: 244 VLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQ 303
Query: 760 TKEEELNAIRTENSSLTKE----------VQDL----KAKQNDQVSFA-SLVEELKK--- 801
+ +E+ + +E +L ++ ++DL K K Q+ A +L+E+L++
Sbjct: 304 SHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKG 363
Query: 802 -VIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQ-LSIT 859
VI E ++ E+ E E+ ++ ++ K + +E++ KE+ E+ ++ LS
Sbjct: 364 MVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTA 423
Query: 860 SKVQELQNLLKGK-EEQMNTMKAVLEEK----EKDLANTGKWLQDLQEENES------LK 908
K +E + LK + +EQ+ T++ EE+ +++L+ + + D+ +++ K
Sbjct: 424 QKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQK 483
Query: 909 AHVQEVA-----------------QHNLKEASSASQFEELEIVLKEKENELKRLEAMLKE 951
H +E+A Q +K A SQ E L+I ++++ E LE + +
Sbjct: 484 LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQ 543
Query: 952 RESDLSSKTQLLQDVQDENKLFKSQIEQLK-------QQNYQQASSFPPHEELLK----- 999
+++ L+ L+D+Q E + ++++I +L+ Q+N Q+ H E K
Sbjct: 544 KKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNK 603
Query: 1000 ---VISEREK--------EISGLWNE-LDSLKDAVEHQRKKNNERQQQVEAVELEAKEVL 1047
V+ E+ K + LW E L LK + + +K E+ +Q + L+ KE+
Sbjct: 604 EITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEI- 662
Query: 1048 KKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKE--------ADEM 1099
+F N + L + K E + +S EV HKL+E D+M
Sbjct: 663 --IFQAHIEEMN---EKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKM 717
Query: 1100 HTLLQLECEKYK--------SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQS 1151
L+ + ++ K S++ E E +Q+ +++++ + N+ ++ + E K +K+ Q+
Sbjct: 718 KQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQA 777
Query: 1152 SFTSSEQELERLRSE------------------NKDIENLRREREHLEMELEKAEMERST 1193
+ E +++R E ++ + + L+ +L E ER
Sbjct: 778 HVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERIL 837
Query: 1194 YVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENS 1253
+V E++AQ + T+L + + Q + L K +E K T V E+
Sbjct: 838 LTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEME------QKVKSLTQVYESK 891
Query: 1254 DVSPETESSEKETMSVSLNQTVTQLQQ----LLQAVNQQLTKEKEHYQVL 1299
E + + + V + Q+++ ++ + Q+L+ +++ +L
Sbjct: 892 LEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHIL 941
Score = 69.7 bits (169), Expect = 2e-11
Identities = 131/627 (20%), Positives = 264/627 (42%), Gaps = 71/627 (11%)
Query: 704 NDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEE 763
N ++ +S QKLQ V V I+E + + E L+ T + E
Sbjct: 52 NRESGDTQSFAQKLQLRVPS-----VESLFRSPIKESLFRSSSKESLVRT------SSRE 100
Query: 764 ELNAIRTENSS--------LTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEE 815
LN + ++S+ + E +DL +D ++ L++ L+++ E
Sbjct: 101 SLNRLDLDSSTASFDPPSDMDSEAEDLVGN-SDSLNKEQLIQRLRRMERSLSSYRGKYSE 159
Query: 816 LLEAELLKVANKEKTVQDLKQE-------IKALKEEIG-NVQLEKAQQLSITSKVQELQN 867
L+ A + K+K L Q I L+EE+ + Q +K Q + ++E
Sbjct: 160 LVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQ 219
Query: 868 LLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENE--SLKAHVQEVAQHNLKEASSA 925
+ + Q++ +K L ++ + K L L+ + E + + + + + +++ +S
Sbjct: 220 YISVLQTQVSLLKQRLRNGPMNV-DVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSV 278
Query: 926 SQFEELEIVLKEKENELKRLEAML---KERESDLSSKTQLLQDVQDENKLFKSQIEQLKQ 982
E L+ +K +EN LKR + + KE+ + L+S+ + LQ+ DE ++E++K
Sbjct: 279 KTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDER---LQELEKIKD 335
Query: 983 QNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELE 1042
+ E K+I++ ++ L +L+ K V + K+ Q E +E++
Sbjct: 336 LHM---------AEKTKLITQL-RDAKNLIEQLEQDKGMVIAETKR-----QMHETLEMK 380
Query: 1043 AKEVLKKLFPKVSVPSNLSYGEWLHGFEKKA-----KECMAGTSGSEEVKVLEHKLK-EA 1096
+E+ + + + + GE L ++K+ +E S +++ + KLK E
Sbjct: 381 EEEIAQL---RSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEM 437
Query: 1097 DE-MHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESH-KTIKQMQSSFT 1154
DE + T+ + E+ S+ E + Q++ +++ + K+ + H K + + + T
Sbjct: 438 DEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELT 497
Query: 1155 SSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRT 1214
Q ER E + + + E+L++ EK + E + KA L E+ KLR
Sbjct: 498 KKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRD 557
Query: 1215 EQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTV-------IENSDVSPETESSEKETM 1267
Q E + + + + SLE + + D V N +++ E + E
Sbjct: 558 LQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELE 617
Query: 1268 SVSLNQTVTQLQQLLQAVNQQLTKEKE 1294
S+ Q ++ LQ + QQ E E
Sbjct: 618 SLKHQQDALWTEK-LQVLKQQYQTEME 643
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 164 bits (416), Expect = 4e-40
Identities = 226/1098 (20%), Positives = 485/1098 (44%), Gaps = 138/1098 (12%)
Query: 298 EDEALCVVDLLKEKSGVIQDALKKSSK--GELTTLIHQLQEKDKLLAAVKE---DAAATK 352
++E L V + + G +++ +K + E L QLQ + +L A +E AA K
Sbjct: 858 DEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKK 917
Query: 353 DRCKQLTQEM---MTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQ 409
+++ ++ + E+E N ++ K ++ ++ ++ + Q+ Q ++ +
Sbjct: 918 QELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAE 977
Query: 410 QVREQMEAEIAHLKQENG-------ILRDAVSNTTNQL--ESKQSAELNKLRQDYARLVN 460
++ME EI L+ +N ++ D ++ ++QL E +++ L K+R +++
Sbjct: 978 AKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMIS 1037
Query: 461 ELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQS 520
+L E+ L++EE ++ E+A +L + + + + E+Q+ I + + +++LQ
Sbjct: 1038 DLEER---LKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQG 1094
Query: 521 KFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEA 580
++E +LH + L ++L+ ++ +L E + + Q +D+ E+ EA
Sbjct: 1095 ALARGDDE--TLHKN--NALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEA 1150
Query: 581 LKAQIQQFHSQIAAQTSASVLAE----ELHKVIAEKDKQIKQTEDSLASERDRLTSKEEE 636
LK +++ AAQ E EL K + E + K E + R R + EE
Sbjct: 1151 LKTELEDTLDTTAAQQELRTKREQEVAELKKALEE---ETKNHEAQIQDMRQRHATALEE 1207
Query: 637 LKDIQNMNFLLKAEVQK-LQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISN 695
L + KA ++K Q L + A E++ +QQ + K + L+ Q+Q E+
Sbjct: 1208 LSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQ-ELHA 1266
Query: 696 KMEEFKILN----DQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELL 751
K+ E L ++ L++E+ + TL+ E K + + K + +L+ +ELL
Sbjct: 1267 KVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGI--KFAKDAASLESQLQDTQELL 1324
Query: 752 ETGLIQVATKEEELNAIRTENSSLTKEVQDLK-AKQNDQVSFASLVEEL---KKVIHEKD 807
+ Q + + E +SL ++ ++ + A++N + +L +L KK + +
Sbjct: 1325 QEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDL 1384
Query: 808 GKIKSVEE-----LLEAELLKVANKEKTV--QDLKQEIKALKEEIGNVQLEKAQQLSITS 860
G I+S+EE L +AE L +EK + L++ L++E+ ++ ++ Q + S
Sbjct: 1385 GTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVAS 1444
Query: 861 KVQELQN-----LLKGKE------EQMNTMKAVLEEKEKDLANTGKWLQDLQE------- 902
+++ Q L + K E+ + +A EKE + + L++ E
Sbjct: 1445 NLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFER 1504
Query: 903 ENESLKAHVQEVAQ---------HNLKEASSA--SQFEELEIVLKEKENELKRLE-AMLK 950
+N+ L+A ++++ H L+++ A Q EE+ L+E E+EL+ E A L+
Sbjct: 1505 QNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLR 1564
Query: 951 ERESDLSSKTQLLQDVQ-------DENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISE 1003
+ + K Q +D+Q ++ +L Q+ +L+ + + + L V S+
Sbjct: 1565 LEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERK-----QRALAVASK 1619
Query: 1004 REKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFP------KVSVP 1057
++ EI +L L+ +E K +E +Q+ ++ + K+ ++L ++
Sbjct: 1620 KKMEI-----DLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQ 1674
Query: 1058 SNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAET 1117
S S + L E + + + SE + H +E DE+ + ++L E
Sbjct: 1675 SKESEKK-LKSLEAEILQLQEELASSERAR--RHAEQERDELADEITNSASGKSALLDEK 1731
Query: 1118 ---EGILQKLQRSVEQEENKWKVKVDESHKTIKQM----------QSSFTSSEQELERLR 1164
E + +L+ +E+E++ ++ D KT Q+ +S+ S+ ++L
Sbjct: 1732 RRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLE 1791
Query: 1165 SENKDIENLRRERE-------------------HLEMELEKAEMERSTYVTEVRELKAQL 1205
+NK+++ +E E LE +LE+ ER+ VR + +L
Sbjct: 1792 RQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKL 1851
Query: 1206 NETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKE 1265
E ++ E+ + + KA ++ ++ ++ +A + T S + E +
Sbjct: 1852 KEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDAT 1911
Query: 1266 TMSVSLNQTVTQLQQLLQ 1283
+ L++ V+ L+ L+
Sbjct: 1912 EANEGLSREVSTLKNRLR 1929
Score = 149 bits (377), Expect = 1e-35
Identities = 241/1149 (20%), Positives = 483/1149 (42%), Gaps = 175/1149 (15%)
Query: 261 EGIQKSGTKKLKTETDKENAEVKFKDFL---------LSLKTMMFSEDEALCV------- 304
E + K K+ K E + E E K + L L +T +F+E E +
Sbjct: 859 EELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQ 918
Query: 305 ------------VDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATK 352
V+ +E++ ++Q+ KK + + L QL E++ ++ + +
Sbjct: 919 ELEEILHDLESRVEEEEERNQILQNE-KKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAE 977
Query: 353 DRCKQLTQEMMTEKERSNVVITR---MKDRIGTL--------EKEHNV--FQNKIHVSYQ 399
+ K++ +E++ +++++ I M+DRI EK N+ +NK V
Sbjct: 978 AKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMIS 1037
Query: 400 ETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLV 459
+ ++ K ++ R+++E L E L+D ++ A++++L+ A+
Sbjct: 1038 DLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAEL--------QAQIDELKLQLAKKE 1089
Query: 460 NELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQ 519
EL + E + K NA + +L+ Q+ E + +E ++ K E ++DL
Sbjct: 1090 EELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKA----EKQKRDLS 1145
Query: 520 SKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKE-ESLQMQVQDI---- 574
+ A + E++ DT ++Q+L + Q + +K + +E ++ + Q+QD+
Sbjct: 1146 EELEALKTELEDT----LDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRH 1201
Query: 575 ----------LEQNEALKAQIQQFHSQIAAQTSASVLAEE---LHKVIAEKDKQIKQTED 621
LEQ + KA +++ ++ +T LA E L +V AE + + K+ +
Sbjct: 1202 ATALEELSEQLEQAKRFKANLEK--NKQGLETDNKELACEVKVLQQVKAESEHKRKKLDA 1259
Query: 622 SL------ASERDRL----TSKEEELK-DIQNMNFLLKAEVQKLQALANEQAAAAHELEK 670
+ SE DRL K +L+ ++ N++ LL+ +K A + A+ +L+
Sbjct: 1260 QVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQD 1319
Query: 671 MQQSVYVKD-DKIRLLEE--QLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNK 727
Q+ + + K+ L QL+ E ++ E+ + + K L+ +V LQ+ +++ K
Sbjct: 1320 TQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKK 1379
Query: 728 --DVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK 785
D + +E + K + LK E L + ++ K + + + L +E+ DL
Sbjct: 1380 VDDDLGTIESLEEAKKKLLKDAEALSQ----RLEEKALAYDKLEKTKNRLQQELDDLTVD 1435
Query: 786 QNDQVSFASLVEELKKVIHEKDGKIKSVE-------ELLEAELLKVANKEKTVQDLKQEI 838
+ Q AS +E+ +K + + KS+ + EAE + K ++ +E
Sbjct: 1436 LDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEA 1495
Query: 839 KALKEEIG--NVQLEKAQQLSITSK------VQELQNLLKGKEEQMNTMKAVLEEKEKDL 890
KEE N QL + ++SK V EL+ + E+Q+ M+ LEE E +L
Sbjct: 1496 LEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDEL 1555
Query: 891 ANTGKWLQDLQEENESLKAHVQEVAQ-----HNLKEASSASQFEELEIVLKEKENEL--- 942
T L+ +++KA + Q + K+ Q ELE L+++ +
Sbjct: 1556 QATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALA 1615
Query: 943 ----KRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASS----FPPH 994
K++E LK+ E+ + + + +V + + ++Q++ +++ + +S F
Sbjct: 1616 VASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQS 1675
Query: 995 EELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQV------------EAVELE 1042
+E K + E EI L EL S + A H ++ +E ++ E LE
Sbjct: 1676 KESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLE 1735
Query: 1043 AK---------------EVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVK 1087
A+ E+L F K ++ + E K A + K
Sbjct: 1736 ARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNK 1795
Query: 1088 VLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIK 1147
L+ KL+E + K+K+ ++ E + +L+ +EQE + +T K
Sbjct: 1796 ELKAKLQELEGAVK------SKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEK 1849
Query: 1148 QMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQL-- 1205
+++ F E E + +E + L+ +LE+AE E + R+L+ +L
Sbjct: 1850 KLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDD 1909
Query: 1206 ----NETLTKLRTEQNERQKVAGDL-----HKAQQSLELIQSKIVKAAGDTTVIENSDVS 1256
NE L++ + R + G + ++ L L + ++ + D T + SDV+
Sbjct: 1910 ATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHL-EGASLELSDDDTESKTSDVN 1968
Query: 1257 PETESSEKE 1265
ET+ + E
Sbjct: 1969 -ETQPPQSE 1976
Score = 145 bits (365), Expect = 3e-34
Identities = 164/789 (20%), Positives = 360/789 (45%), Gaps = 91/789 (11%)
Query: 544 QQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAE 603
Q ++ L+++ E + K + E ++ + Q +LE+ L Q+Q A+T AE
Sbjct: 855 QAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQ-------AETELFAEAE 907
Query: 604 ELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAA 663
E+ +A K +++++ L S R+ +EE + +QN ++A +Q L+ +E+
Sbjct: 908 EMRARLAAKKQELEEILHDLES---RVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG 964
Query: 664 AAHELEKMQQSVYVKDDKIRLLEEQ---LQHEISNKMEEFKILNDQ----NKALKSEVQK 716
A +K+Q + KI+ +EE+ L+ + S ++E K++ D+ + L E +K
Sbjct: 965 AR---QKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1021
Query: 717 LQTLVSEQPNKDV--------VEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAI 768
+ L + ++V +++ EK QE ++ + ++ Q+A + +++ +
Sbjct: 1022 AKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDEL 1081
Query: 769 RTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKE 828
+ + + +E+Q A+ +D+ + KV+ E +I ++E E+E E
Sbjct: 1082 KLQLAKKEEELQGALARGDDETLHKN---NALKVVRELQAQIAELQEDFESEKASRNKAE 1138
Query: 829 KTVQDLKQEIKALKEEI-GNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKE 887
K +DL +E++ALK E+ + AQQ T + QE+ L K EE+ +A +++
Sbjct: 1139 KQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMR 1198
Query: 888 KDLANTGKWLQDLQEENESLKAHVQEVAQH-NLKEASSASQFEELEIVLKEKENELKRLE 946
+ A + L + E+ + KA++++ Q A + + L+ V E E++ K+L+
Sbjct: 1199 QRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLD 1258
Query: 947 AMLKERES----------DLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPH-- 994
A ++E + +L+ K LQ+ D + E+ + + A+S
Sbjct: 1259 AQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQ 1318
Query: 995 --EELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFP 1052
+ELL+ + ++ +S +L+ K++++ Q+++ E ++ +E K+VL
Sbjct: 1319 DTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLE------KQVL----- 1367
Query: 1053 KVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKS 1112
++ S L+ +KK + + EE K + LK+A+ + L+ + Y
Sbjct: 1368 --ALQSQLA------DTKKKVDDDLGTIESLEEAK--KKLLKDAEALSQRLEEKALAYDK 1417
Query: 1113 VLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE- 1171
L+K + ++QE + V +D +Q+ S+ +++ ++L +E K I
Sbjct: 1418 --------LEKTKNRLQQELDDLTVDLDHQ----RQVASNLEKKQKKFDQLLAEEKSISA 1465
Query: 1172 NLRREREHLEMELEKAE---MERSTYVTEVRELKAQLNETLTKLRTEQNE----RQKVAG 1224
ER+ E E + E + + + E E K + +LR + + + V
Sbjct: 1466 RYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGK 1525
Query: 1225 DLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQA 1284
++H+ ++S ++ ++ + T +E + + K + V++ Q ++ LQ
Sbjct: 1526 NVHELEKSKRALEQQVEEM---RTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQT 1582
Query: 1285 VNQQLTKEK 1293
++Q ++K
Sbjct: 1583 RDEQNEEKK 1591
Score = 134 bits (337), Expect = 6e-31
Identities = 158/715 (22%), Positives = 322/715 (45%), Gaps = 76/715 (10%)
Query: 609 IAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHEL 668
+ ++++++ ++ L +++ T E EL++++ + L E L + E
Sbjct: 847 VTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEA 906
Query: 669 EKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKD 728
E+M+ + K ++ + L+ + + E +IL ++ K +++ +Q L+ + E+
Sbjct: 907 EEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGAR 966
Query: 729 VVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQND 788
Q+EK E ++ EEE+ + +NS KE K D
Sbjct: 967 QKLQLEKVTAE----------------AKIKKMEEEILLLEDQNSKFIKE----KKLMED 1006
Query: 789 QVSFAS--LVEELKKVIHEKDGKIKSVEELLEAEL-LKVANKEKTVQDLKQEIKALKEEI 845
+++ S L EE +K + KI++ +E++ ++L ++ +EKT Q+L++ + L E
Sbjct: 1007 RIAECSSQLAEEEEKA--KNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGET 1064
Query: 846 GNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENE 905
++Q + A+ + +++ EL+ L KEE++ A +++ N K +++LQ +
Sbjct: 1065 TDLQDQIAE---LQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIA 1121
Query: 906 SLKAHVQ-EVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQ 964
L+ + E A N E EELE + E E+ L A + R +L +
Sbjct: 1122 ELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKK 1181
Query: 965 DVQDENKLFKSQIEQLKQ----------QNYQQASSFPPHEELLKVISERE-KEISGLWN 1013
+++E K ++QI+ ++Q + +QA F + E K E + KE++
Sbjct: 1182 ALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVK 1241
Query: 1014 ELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNL--SYGEWLHGFEK 1071
L +K EH+RKK + + Q++ A E + +L K S N + L EK
Sbjct: 1242 VLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEK 1301
Query: 1072 KAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQE 1131
K G +++ LE +L++ E LLQ E + + L R +E+E
Sbjct: 1302 K------GIKFAKDAASLESQLQDTQE---LLQEETRQKLN--------LSSRIRQLEEE 1344
Query: 1132 ENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKD----IENLRREREHLEMELEKA 1187
+N + + +E + K ++ + + +L + + D IE+L ++ L + E
Sbjct: 1345 KNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEAL 1404
Query: 1188 EM---ERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLE--LIQSKIVK 1242
E++ ++ + K +L + L L + + +++VA +L K Q+ + L + K +
Sbjct: 1405 SQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSIS 1464
Query: 1243 AAGDTTVIENSDVSPETESSEKETMSVSLNQTV---TQLQQLLQAVNQQLTKEKE 1294
A E D E E+ EKET ++SL + + + ++ + N+QL + E
Sbjct: 1465 A----RYAEERD-RAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME 1514
Score = 103 bits (256), Expect = 1e-21
Identities = 122/576 (21%), Positives = 259/576 (44%), Gaps = 64/576 (11%)
Query: 730 VEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ---DLKAKQ 786
V + E+ +Q KDE+L V+E ++ E + + E + L +++Q +L A+
Sbjct: 847 VTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEA 906
Query: 787 ND-QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEI 845
+ + A+ +EL++++H+ + +++ EE + + + +QDL++++ +
Sbjct: 907 EEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGAR 966
Query: 846 GNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENE 905
+QLEK + K++E LL+ + + K ++E++ + ++ L EE E
Sbjct: 967 QKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSS------QLAEEEE 1020
Query: 906 SLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQD 965
K +A+ K+ S EE ++ EL++ + L +DL + LQ
Sbjct: 1021 KAK----NLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQA 1076
Query: 966 VQDENKLFKSQIEQLKQQNYQQASSFPPHEE-LLKVISEREKEISGLWNELDSLKDAVEH 1024
DE KL ++ E+ Q + H+ LKV+ E + +I+ L + +S K +
Sbjct: 1077 QIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNK 1136
Query: 1025 QRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSE 1084
K+ + +++EA++ E ++ L + A + T +
Sbjct: 1137 AEKQKRDLSEELEALKTELEDTL----------------------DTTAAQQELRTKREQ 1174
Query: 1085 EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHK 1144
EV L+ L+E + H Q++ + + A L++L +EQ + ++K ++++ +
Sbjct: 1175 EVAELKKALEEETKNHEA-QIQDMRQRHATA-----LEELSEQLEQAK-RFKANLEKNKQ 1227
Query: 1145 TIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQ 1204
+ E + + L E K ++ ++ E EH +L+ E V+E L+ +
Sbjct: 1228 GL----------ETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVE 1277
Query: 1205 LNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEK 1264
L E +KL QNE V+ L +A++ K +K A D +E+ + E+
Sbjct: 1278 LAEKASKL---QNELDNVSTLLEEAEK-------KGIKFAKDAASLESQLQDTQELLQEE 1327
Query: 1265 ETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
++L+ + QL++ ++ +Q +E+E + LE
Sbjct: 1328 TRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLE 1363
Score = 67.4 bits (163), Expect = 9e-11
Identities = 118/678 (17%), Positives = 259/678 (38%), Gaps = 74/678 (10%)
Query: 45 QKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNV 104
Q+L+ +T +K + ++ E + +L E E L + Q+A V
Sbjct: 1321 QELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKV 1380
Query: 105 VE---TSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAAS 161
+ T S+ E KKK K L +++ +++ A + + TK +
Sbjct: 1381 DDDLGTIESLEEAKKKLLKDAEALSQRLEEKALA-------YDKLEKTKNRLQQELDDLT 1433
Query: 162 KKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENV 221
Q++ + + + KK + L+ K A + + E A +++++T+ +
Sbjct: 1434 VDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAE-------AEAREKETKAL 1486
Query: 222 FVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAE 281
+ L A + + D +++ K D + + + K E E
Sbjct: 1487 SLARALEEALEAKEEFERQNKQLRADMEDLMSS-KDDVGKNVHELEKSKRALEQQVEEMR 1545
Query: 282 VKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLL 341
+ ++ EDE D K + V A+K + +L T Q +EK +LL
Sbjct: 1546 TQLEEL----------EDELQATEDA-KLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLL 1594
Query: 342 -AAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE 400
V+E A +D KQ + K++ + + ++ +I K + ++ +
Sbjct: 1595 IKQVRELEAELEDERKQRAL-AVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQ 1653
Query: 401 TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK--LRQDYARL 458
+ Q + ++ R + A K+ L+ + E S+E + Q+ L
Sbjct: 1654 MKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDEL 1713
Query: 459 VNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDL 518
+E+T +K+ E QL+ +L+E + E + RK T
Sbjct: 1714 ADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTL--------- 1764
Query: 519 QSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQN 578
+V +L+++L +E+ K ++ + Q++ QN
Sbjct: 1765 ---------QVDTLNAELA------------------AERSAAQKSDNARQQLE---RQN 1794
Query: 579 EALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELK 638
+ LKA++Q+ + ++ A++ A L I + ++Q++Q A+ + E++LK
Sbjct: 1795 KELKAKLQELEGAVKSKFKATISA--LEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLK 1852
Query: 639 DIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKME 698
+I + + + + A +L++ + + + +LQ E+ + E
Sbjct: 1853 EIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATE 1912
Query: 699 EFKILNDQNKALKSEVQK 716
+ L+ + LK+ +++
Sbjct: 1913 ANEGLSREVSTLKNRLRR 1930
Score = 53.9 bits (128), Expect = 1e-06
Identities = 58/279 (20%), Positives = 123/279 (44%), Gaps = 31/279 (11%)
Query: 1026 RKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEE 1085
RK ++QQQ+ A LK L + L + +W F K K + T EE
Sbjct: 803 RKAFAKKQQQLSA--------LKVLQRNCAAYLKLRHWQWWRVFTK-VKPLLQVTRQEEE 853
Query: 1086 VKVLEHKLKEADEMHTLLQLECE----KYKSVLAETEGILQKLQRSVEQEENKWKVKVDE 1141
++ + +L + E T ++ E E K++ +L E + ++LQ E
Sbjct: 854 LQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETEL----------- 902
Query: 1142 SHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVREL 1201
++M++ + +QELE + D+E+ E E L+ E+ +++L
Sbjct: 903 -FAEAEEMRARLAAKKQELEEILH---DLESRVEEEEERNQILQN---EKKKMQAHIQDL 955
Query: 1202 KAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETES 1261
+ QL+E + Q E+ + K ++ + L++ + K + ++E+ ++
Sbjct: 956 EEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQL 1015
Query: 1262 SEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
+E+E + +L + + + ++ + ++L KE++ Q LE
Sbjct: 1016 AEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELE 1054
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 164 bits (414), Expect = 7e-40
Identities = 238/1075 (22%), Positives = 462/1075 (42%), Gaps = 130/1075 (12%)
Query: 294 MMFSEDEALCVVDLLKEKSGVIQDALKKSSK--GELTTLIHQLQEKDKLLAAVKE---DA 348
M EDE + ++ +++ +K S+ E L QLQ + +L A +E
Sbjct: 861 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRL 920
Query: 349 AATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNK---IHVSYQETQQMQ 405
AA K +++ EM E +DR L+ E + + +E + +
Sbjct: 921 AAKKQELEEILHEMEARLEEE-------EDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973
Query: 406 MKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEK 465
K Q + EA+I L+ E ++ D +K S E L + + L L E+
Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQ--------NNKLSKERKLLEERISDLTTNLAEE 1025
Query: 466 TGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRK----------RTAEHEAAQ 515
K + K E ++L+V+L++ E+ +E++ RK + A+ +A
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1085
Query: 516 QDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQL----------MESEQKRVNKEE 565
+L+ + KE E+Q+ ++L D + K +++ +L ++SE+ NK E
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145
Query: 566 SLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEK-DKQIKQTEDSLA 624
Q +D+ E+ EALK +++ A Q E+ V+ + D++ + E +
Sbjct: 1146 K---QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202
Query: 625 SERDRLTSKEEELKDIQNMNFLLKAEVQK-LQALANEQAAAAHELEKMQQSVYVKDDKIR 683
R + EEL + KA + K Q L E A A EL + Q+ + K +
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262
Query: 684 LLEEQLQHEISNKMEEFKI----LNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQE 739
LE Q+Q E+ +K + + LND+ L++EV+ + +++E K + ++ K +
Sbjct: 1263 KLEAQVQ-ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI--KLAKDVAS 1319
Query: 740 KDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEV-QDLKAKQNDQVSFASLVEE 798
+L+ +ELL+ Q +L + E +SL ++ ++++AKQN + ++L +
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 799 LKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSI 858
L D K K+ + TV+ L++ K ++EI N+ + ++ +
Sbjct: 1380 LS------DSK------------KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1421
Query: 859 TSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGK----WLQDLQEENESLKAHVQE- 913
K+++ +N L +++++ + L+ + + ++N K + Q L EE + E
Sbjct: 1422 YDKLEKTKNRL---QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1478
Query: 914 ---VAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDL-SSKTQL---LQDV 966
A+ KE + S LE L+ KE EL+R MLK DL SSK + + ++
Sbjct: 1479 DRAEAEAREKETKALSLARALEEALEAKE-ELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1537
Query: 967 QDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQR 1026
+ + ++Q+E++K Q + E+ + + + G + +D E
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD--EQNE 1595
Query: 1027 KKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGS--- 1083
+K + Q+Q+ E E ++ K+ + L G+ L E +A + G +
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE-GD-LKDLELQADSAIKGREEAIKQ 1653
Query: 1084 -----EEVKVLEHKLKEA----DEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENK 1134
++K + +L++A DE+ + +K KS+ A+ L +LQ + E
Sbjct: 1654 LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD----LMQLQEDLAAAERA 1709
Query: 1135 WKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTY 1194
K E + +++ SS + L+ E + +E LE ELE+ +
Sbjct: 1710 RKQADLEKEELAEELASSLSGRNA----LQDEKRRLE---ARIAQLEEELEEEQGNMEAM 1762
Query: 1195 VTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKI------VKAAGDTT 1248
VR+ Q + +L TE++ QK + ++ + ++SK+ VK+ +T
Sbjct: 1763 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1822
Query: 1249 V------IENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1297
+ I + E E+ EK+ + SL Q +L+++L V + K E Y+
Sbjct: 1823 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE-RKMAEQYK 1876
Score = 131 bits (329), Expect = 5e-30
Identities = 150/711 (21%), Positives = 325/711 (45%), Gaps = 68/711 (9%)
Query: 609 IAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHEL 668
+ ++++++ ED L ++R E ELK+++ + L E LQ + E
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 669 EKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKD 728
E+M+ + K ++ E++ HE+ ++EE + D+ + L++E +K+ Q D
Sbjct: 914 EEMRVRLAAKKQEL----EEILHEMEARLEEEE---DRGQQLQAERKKM-----AQQMLD 961
Query: 729 VVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQND 788
+ EQ+E+ +E + +E++ T ++ E+E+ + +N+ L+KE + L+ + +D
Sbjct: 962 LEEQLEE--EEAARQKLQLEKV--TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1017
Query: 789 QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEI-GN 847
+ + EE K + + K +S+ LE L K +EK+ +QE++ LK ++ G+
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK---EEKS----RQELEKLKRKLEGD 1070
Query: 848 VQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESL 907
Q + +++ EL+ L KEE++ A L+++ N K +++L+ L
Sbjct: 1071 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1130
Query: 908 KAHV-QEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDV 966
+ + E A N E EELE + E E+ L + R T L + +
Sbjct: 1131 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1190
Query: 967 QDENKLFKSQIEQLKQQNYQQASSFPPHEELLK-----------VISEREKEISGLWNEL 1015
+E + ++Q+++++Q++ Q E K + + +++G L
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250
Query: 1016 DSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSN--LSYGEWLHGFEKKA 1073
K VEH++KK + Q++++ + + +L KV N S L+ E KA
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310
Query: 1074 KECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEEN 1133
+ +++V L +L++ E LLQ E + +V + R +E+E N
Sbjct: 1311 IKL------AKDVASLSSQLQDTQE---LLQEETRQKLNVSTKL--------RQLEEERN 1353
Query: 1134 KWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKD----IENLRREREHLEMELEKAEM 1189
+ ++DE + + ++ ++ +L + + +D +E L ++ + E+E
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413
Query: 1190 ---ERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGD 1246
E++ ++ + K +L + L L + + ++++ +L K Q+ + + + +
Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL---LAEEKNI 1470
Query: 1247 TTVIENSDVSPETESSEKETMSVSLNQTV---TQLQQLLQAVNQQLTKEKE 1294
++ + E E+ EKET ++SL + + + ++ L+ N+ L E E
Sbjct: 1471 SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME 1521
Score = 115 bits (288), Expect = 3e-25
Identities = 196/948 (20%), Positives = 388/948 (40%), Gaps = 128/948 (13%)
Query: 40 KQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAP 99
K K E + + KK EK + + ++++ KL + +Q+A
Sbjct: 1036 KNKHESMISELEVRLKKEEKSRQELEKLKR---------------KLEGDASDFHEQIAD 1080
Query: 100 VPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAA 159
+ + E + +++++ + L++++ ++++A K +++E Q SE A
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQEDLDSERA 1139
Query: 160 ASKKKPGQKKSKNGS---------DDQDKKVETLMVPSKR-QEALPLHQETKQESGSGKK 209
A K QK+ D D + +KR QE L + +E+ S +
Sbjct: 1140 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1199
Query: 210 KASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGT- 268
+ +QK V+E + N D + ++E DL +V G K
Sbjct: 1200 QVQEMRQKHAQA-VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1258
Query: 269 ---KKLKTE--------TDKENAEVKFKDFLLSLK------TMMFSEDEALCV-----VD 306
KKL+ + +D E A + D + L+ T M +E E + V
Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1318
Query: 307 LLKEKSGVIQDALKKSSKGEL--TTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMT 364
L + Q+ L++ ++ +L +T + QL+E+ L ++ K ++ +
Sbjct: 1319 SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNI 1378
Query: 365 EKERSNVVITRMKDRIGTLEKEHNVFQNKIH---VSYQETQQMQMKFQQVREQMEAEIAH 421
+ S + + LE+ FQ +I Y+E K ++ + +++ E+
Sbjct: 1379 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1438
Query: 422 LKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQ 481
L + R VSN LE KQ K Q A N ++ + + E + + E
Sbjct: 1439 LVVDLDNQRQLVSN----LEKKQ----RKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490
Query: 482 AATQLKVQLQEAERRWEEVQSYIRKRTAEHE---AAQQDLQSKFVAKENEVQSLHSKLTD 538
A L L+EA EE++ + AE E +++ D+ E ++L +++ +
Sbjct: 1491 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1550
Query: 539 TLVSKQQLEQRLMQLMESEQKRVNKEESLQ---------MQVQDILEQNEALKAQIQ--- 586
K QLE+ +L +E ++ E ++Q +Q +D EQNE + Q+Q
Sbjct: 1551 M---KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD--EQNEEKRRQLQRQL 1605
Query: 587 -QFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERD----RLTSKEEELKDIQ 641
++ +++ + LA K + K ++ DS R+ +L + ++KD Q
Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665
Query: 642 NMNFLLKAEVQKLQALANEQAAAAHELE----KMQQSVYVKD---DKIRLLEEQLQHEIS 694
+A ++ A A E A LE ++Q+ + + + L +E+L E++
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 695 NKMEEFKILNDQNKALKSEVQKLQT-LVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLET 753
+ + L D+ + L++ + +L+ L EQ N + + + ++ E+L
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN------- 1778
Query: 754 GLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSV 813
++AT+ + L ++ ++L++K ++ ++ + K I + KI +
Sbjct: 1779 ---ELATERSTAQKNESARQQLERQNKELRSKLHEMEG--AVKSKFKSTIAALEAKIAQL 1833
Query: 814 EELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLE-------KAQQLSITSKVQELQ 866
EE +E E K+ + LKQ+ K LKE + V+ E K Q ++V++L+
Sbjct: 1834 EEQVEQE---AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890
Query: 867 NLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEV 914
L+ E EE ++ AN K ++L E ES +A +EV
Sbjct: 1891 RQLEEAE----------EESQRINANRRKLQRELDEATESNEAMGREV 1928
Score = 58.2 bits (139), Expect = 5e-08
Identities = 108/569 (18%), Positives = 212/569 (37%), Gaps = 95/569 (16%)
Query: 30 KETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDA 89
K+ +D++LA++K + D+ +AE ++ + K + E E+ + +
Sbjct: 1456 KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1515
Query: 90 LAVEDDQVAP----VPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEP 145
L E + + V NV E S R + + ++ K LEE +
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE--------------DE 1561
Query: 146 VPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESG 205
+ T+ E K ++ D+Q+++ + + L E KQ +
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA- 1620
Query: 206 SGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQK 265
A++ K+K E D L ADS+ + + E I L+ Q +
Sbjct: 1621 ----LAAAAKKKLEGDLKDLEL-----------QADSA-IKGREEAIKQLRKLQAQ---- 1660
Query: 266 SGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKG 325
KDF L+ S DE ++K+ KS +
Sbjct: 1661 ------------------MKDFQRELEDARASRDEIFATAKENEKKA--------KSLEA 1694
Query: 326 ELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEK 385
+L QLQE ++ A K+ + ++ + R++ RI LE+
Sbjct: 1695 DLM----QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1750
Query: 386 EHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQS 445
E Q + ++ + +Q+ ++ E + Q+N R + +L SK
Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS-TAQKNESARQQLERQNKELRSKLH 1809
Query: 446 AELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIR 505
++ + + L K +L+++ Q+ +QAAT+ L++ +++ +E+ +
Sbjct: 1810 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK---SLKQKDKKLKEILLQV- 1865
Query: 506 KRTAEHEAAQQDLQSKFVAKEN-EVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVN-K 563
E E + + K N V+ L K+QLE+ E E +R+N
Sbjct: 1866 ----EDERKMAEQYKEQAEKGNARVKQL----------KRQLEEA-----EEESQRINAN 1906
Query: 564 EESLQMQVQDILEQNEALKAQIQQFHSQI 592
LQ ++ + E NEA+ ++ S++
Sbjct: 1907 RRKLQRELDEATESNEAMGREVNALKSKL 1935
Score = 50.1 bits (118), Expect = 1e-05
Identities = 56/282 (19%), Positives = 119/282 (42%), Gaps = 37/282 (13%)
Query: 1026 RKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEE 1085
RK +RQQQ+ A+++ + L L +W F K K + T EE
Sbjct: 810 RKAFAKRQQQLTAMKVIQRNCAAYL--------KLRNWQWWRLFTK-VKPLLQVTRQEEE 860
Query: 1086 VKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKT 1145
++ E +L++ E QK + +++ E K +E +
Sbjct: 861 MQAKEDELQKTKERQ---------------------QKAENELKELEQKHSQLTEEKNLL 899
Query: 1146 IKQMQSS---FTSSEQELERLRSENKDIENLRRERE-HLEMELEKAEM---ERSTYVTEV 1198
+Q+Q+ + +E+ RL ++ +++E + E E LE E ++ + ER ++
Sbjct: 900 QEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQM 959
Query: 1199 RELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPE 1258
+L+ QL E + Q E+ + K + + ++ + K + + ++E
Sbjct: 960 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT 1019
Query: 1259 TESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
T +E+E + +L + + + ++ + +L KE++ Q LE
Sbjct: 1020 TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1061
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 164 bits (414), Expect = 7e-40
Identities = 238/1075 (22%), Positives = 462/1075 (42%), Gaps = 130/1075 (12%)
Query: 294 MMFSEDEALCVVDLLKEKSGVIQDALKKSSK--GELTTLIHQLQEKDKLLAAVKE---DA 348
M EDE + ++ +++ +K S+ E L QLQ + +L A +E
Sbjct: 854 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRL 913
Query: 349 AATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNK---IHVSYQETQQMQ 405
AA K +++ EM E +DR L+ E + + +E + +
Sbjct: 914 AAKKQELEEILHEMEARLEEE-------EDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966
Query: 406 MKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEK 465
K Q + EA+I L+ E ++ D +K S E L + + L L E+
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQ--------NNKLSKERKLLEERISDLTTNLAEE 1018
Query: 466 TGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRK----------RTAEHEAAQ 515
K + K E ++L+V+L++ E+ +E++ RK + A+ +A
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1078
Query: 516 QDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQL----------MESEQKRVNKEE 565
+L+ + KE E+Q+ ++L D + K +++ +L ++SE+ NK E
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138
Query: 566 SLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEK-DKQIKQTEDSLA 624
Q +D+ E+ EALK +++ A Q E+ V+ + D++ + E +
Sbjct: 1139 K---QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195
Query: 625 SERDRLTSKEEELKDIQNMNFLLKAEVQK-LQALANEQAAAAHELEKMQQSVYVKDDKIR 683
R + EEL + KA + K Q L E A A EL + Q+ + K +
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255
Query: 684 LLEEQLQHEISNKMEEFKI----LNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQE 739
LE Q+Q E+ +K + + LND+ L++EV+ + +++E K + ++ K +
Sbjct: 1256 KLEAQVQ-ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI--KLAKDVAS 1312
Query: 740 KDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEV-QDLKAKQNDQVSFASLVEE 798
+L+ +ELL+ Q +L + E +SL ++ ++++AKQN + ++L +
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 799 LKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSI 858
L D K K+ + TV+ L++ K ++EI N+ + ++ +
Sbjct: 1373 LS------DSK------------KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1414
Query: 859 TSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGK----WLQDLQEENESLKAHVQE- 913
K+++ +N L +++++ + L+ + + ++N K + Q L EE + E
Sbjct: 1415 YDKLEKTKNRL---QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1471
Query: 914 ---VAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDL-SSKTQL---LQDV 966
A+ KE + S LE L+ KE EL+R MLK DL SSK + + ++
Sbjct: 1472 DRAEAEAREKETKALSLARALEEALEAKE-ELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1530
Query: 967 QDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQR 1026
+ + ++Q+E++K Q + E+ + + + G + +D E
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD--EQNE 1588
Query: 1027 KKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGS--- 1083
+K + Q+Q+ E E ++ K+ + L G+ L E +A + G +
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE-GD-LKDLELQADSAIKGREEAIKQ 1646
Query: 1084 -----EEVKVLEHKLKEA----DEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENK 1134
++K + +L++A DE+ + +K KS+ A+ L +LQ + E
Sbjct: 1647 LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD----LMQLQEDLAAAERA 1702
Query: 1135 WKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTY 1194
K E + +++ SS + L+ E + +E LE ELE+ +
Sbjct: 1703 RKQADLEKEELAEELASSLSGRNA----LQDEKRRLE---ARIAQLEEELEEEQGNMEAM 1755
Query: 1195 VTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKI------VKAAGDTT 1248
VR+ Q + +L TE++ QK + ++ + ++SK+ VK+ +T
Sbjct: 1756 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1815
Query: 1249 V------IENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1297
+ I + E E+ EK+ + SL Q +L+++L V + K E Y+
Sbjct: 1816 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE-RKMAEQYK 1869
Score = 131 bits (329), Expect = 5e-30
Identities = 150/711 (21%), Positives = 325/711 (45%), Gaps = 68/711 (9%)
Query: 609 IAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHEL 668
+ ++++++ ED L ++R E ELK+++ + L E LQ + E
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 669 EKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKD 728
E+M+ + K ++ E++ HE+ ++EE + D+ + L++E +K+ Q D
Sbjct: 907 EEMRVRLAAKKQEL----EEILHEMEARLEEEE---DRGQQLQAERKKM-----AQQMLD 954
Query: 729 VVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQND 788
+ EQ+E+ +E + +E++ T ++ E+E+ + +N+ L+KE + L+ + +D
Sbjct: 955 LEEQLEE--EEAARQKLQLEKV--TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1010
Query: 789 QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEI-GN 847
+ + EE K + + K +S+ LE L K +EK+ +QE++ LK ++ G+
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK---EEKS----RQELEKLKRKLEGD 1063
Query: 848 VQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESL 907
Q + +++ EL+ L KEE++ A L+++ N K +++L+ L
Sbjct: 1064 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1123
Query: 908 KAHV-QEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDV 966
+ + E A N E EELE + E E+ L + R T L + +
Sbjct: 1124 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1183
Query: 967 QDENKLFKSQIEQLKQQNYQQASSFPPHEELLK-----------VISEREKEISGLWNEL 1015
+E + ++Q+++++Q++ Q E K + + +++G L
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1243
Query: 1016 DSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSN--LSYGEWLHGFEKKA 1073
K VEH++KK + Q++++ + + +L KV N S L+ E KA
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303
Query: 1074 KECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEEN 1133
+ +++V L +L++ E LLQ E + +V + R +E+E N
Sbjct: 1304 IKL------AKDVASLSSQLQDTQE---LLQEETRQKLNVSTKL--------RQLEEERN 1346
Query: 1134 KWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKD----IENLRREREHLEMELEKAEM 1189
+ ++DE + + ++ ++ +L + + +D +E L ++ + E+E
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 1190 ---ERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGD 1246
E++ ++ + K +L + L L + + ++++ +L K Q+ + + + +
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL---LAEEKNI 1463
Query: 1247 TTVIENSDVSPETESSEKETMSVSLNQTV---TQLQQLLQAVNQQLTKEKE 1294
++ + E E+ EKET ++SL + + + ++ L+ N+ L E E
Sbjct: 1464 SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME 1514
Score = 115 bits (288), Expect = 3e-25
Identities = 196/948 (20%), Positives = 388/948 (40%), Gaps = 128/948 (13%)
Query: 40 KQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAP 99
K K E + + KK EK + + ++++ KL + +Q+A
Sbjct: 1029 KNKHESMISELEVRLKKEEKSRQELEKLKR---------------KLEGDASDFHEQIAD 1073
Query: 100 VPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAA 159
+ + E + +++++ + L++++ ++++A K +++E Q SE A
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQEDLDSERA 1132
Query: 160 ASKKKPGQKKSKNGS---------DDQDKKVETLMVPSKR-QEALPLHQETKQESGSGKK 209
A K QK+ D D + +KR QE L + +E+ S +
Sbjct: 1133 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1192
Query: 210 KASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGT- 268
+ +QK V+E + N D + ++E DL +V G K
Sbjct: 1193 QVQEMRQKHAQA-VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1251
Query: 269 ---KKLKTE--------TDKENAEVKFKDFLLSLK------TMMFSEDEALCV-----VD 306
KKL+ + +D E A + D + L+ T M +E E + V
Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1311
Query: 307 LLKEKSGVIQDALKKSSKGEL--TTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMT 364
L + Q+ L++ ++ +L +T + QL+E+ L ++ K ++ +
Sbjct: 1312 SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNI 1371
Query: 365 EKERSNVVITRMKDRIGTLEKEHNVFQNKIH---VSYQETQQMQMKFQQVREQMEAEIAH 421
+ S + + LE+ FQ +I Y+E K ++ + +++ E+
Sbjct: 1372 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1431
Query: 422 LKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQ 481
L + R VSN LE KQ K Q A N ++ + + E + + E
Sbjct: 1432 LVVDLDNQRQLVSN----LEKKQ----RKFDQLLAEEKNISSKYADERDRAEAEAREKET 1483
Query: 482 AATQLKVQLQEAERRWEEVQSYIRKRTAEHE---AAQQDLQSKFVAKENEVQSLHSKLTD 538
A L L+EA EE++ + AE E +++ D+ E ++L +++ +
Sbjct: 1484 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1543
Query: 539 TLVSKQQLEQRLMQLMESEQKRVNKEESLQ---------MQVQDILEQNEALKAQIQ--- 586
K QLE+ +L +E ++ E ++Q +Q +D EQNE + Q+Q
Sbjct: 1544 M---KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD--EQNEEKRRQLQRQL 1598
Query: 587 -QFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERD----RLTSKEEELKDIQ 641
++ +++ + LA K + K ++ DS R+ +L + ++KD Q
Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1658
Query: 642 NMNFLLKAEVQKLQALANEQAAAAHELE----KMQQSVYVKD---DKIRLLEEQLQHEIS 694
+A ++ A A E A LE ++Q+ + + + L +E+L E++
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 695 NKMEEFKILNDQNKALKSEVQKLQT-LVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLET 753
+ + L D+ + L++ + +L+ L EQ N + + + ++ E+L
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN------- 1771
Query: 754 GLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSV 813
++AT+ + L ++ ++L++K ++ ++ + K I + KI +
Sbjct: 1772 ---ELATERSTAQKNESARQQLERQNKELRSKLHEMEG--AVKSKFKSTIAALEAKIAQL 1826
Query: 814 EELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLE-------KAQQLSITSKVQELQ 866
EE +E E K+ + LKQ+ K LKE + V+ E K Q ++V++L+
Sbjct: 1827 EEQVEQE---AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1883
Query: 867 NLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEV 914
L+ E EE ++ AN K ++L E ES +A +EV
Sbjct: 1884 RQLEEAE----------EESQRINANRRKLQRELDEATESNEAMGREV 1921
Score = 58.2 bits (139), Expect = 5e-08
Identities = 108/569 (18%), Positives = 212/569 (37%), Gaps = 95/569 (16%)
Query: 30 KETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDA 89
K+ +D++LA++K + D+ +AE ++ + K + E E+ + +
Sbjct: 1449 KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1508
Query: 90 LAVEDDQVAP----VPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEP 145
L E + + V NV E S R + + ++ K LEE +
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE--------------DE 1554
Query: 146 VPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESG 205
+ T+ E K ++ D+Q+++ + + L E KQ +
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA- 1613
Query: 206 SGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQK 265
A++ K+K E D L ADS+ + + E I L+ Q +
Sbjct: 1614 ----LAAAAKKKLEGDLKDLEL-----------QADSA-IKGREEAIKQLRKLQAQ---- 1653
Query: 266 SGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKG 325
KDF L+ S DE ++K+ KS +
Sbjct: 1654 ------------------MKDFQRELEDARASRDEIFATAKENEKKA--------KSLEA 1687
Query: 326 ELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEK 385
+L QLQE ++ A K+ + ++ + R++ RI LE+
Sbjct: 1688 DLM----QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1743
Query: 386 EHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQS 445
E Q + ++ + +Q+ ++ E + Q+N R + +L SK
Sbjct: 1744 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS-TAQKNESARQQLERQNKELRSKLH 1802
Query: 446 AELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIR 505
++ + + L K +L+++ Q+ +QAAT+ L++ +++ +E+ +
Sbjct: 1803 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK---SLKQKDKKLKEILLQV- 1858
Query: 506 KRTAEHEAAQQDLQSKFVAKEN-EVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVN-K 563
E E + + K N V+ L K+QLE+ E E +R+N
Sbjct: 1859 ----EDERKMAEQYKEQAEKGNARVKQL----------KRQLEEA-----EEESQRINAN 1899
Query: 564 EESLQMQVQDILEQNEALKAQIQQFHSQI 592
LQ ++ + E NEA+ ++ S++
Sbjct: 1900 RRKLQRELDEATESNEAMGREVNALKSKL 1928
Score = 50.1 bits (118), Expect = 1e-05
Identities = 56/282 (19%), Positives = 119/282 (42%), Gaps = 37/282 (13%)
Query: 1026 RKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEE 1085
RK +RQQQ+ A+++ + L L +W F K K + T EE
Sbjct: 803 RKAFAKRQQQLTAMKVIQRNCAAYL--------KLRNWQWWRLFTK-VKPLLQVTRQEEE 853
Query: 1086 VKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKT 1145
++ E +L++ E QK + +++ E K +E +
Sbjct: 854 MQAKEDELQKTKERQ---------------------QKAENELKELEQKHSQLTEEKNLL 892
Query: 1146 IKQMQSS---FTSSEQELERLRSENKDIENLRRERE-HLEMELEKAEM---ERSTYVTEV 1198
+Q+Q+ + +E+ RL ++ +++E + E E LE E ++ + ER ++
Sbjct: 893 QEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQM 952
Query: 1199 RELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPE 1258
+L+ QL E + Q E+ + K + + ++ + K + + ++E
Sbjct: 953 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT 1012
Query: 1259 TESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
T +E+E + +L + + + ++ + +L KE++ Q LE
Sbjct: 1013 TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1054
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 163 bits (413), Expect = 9e-40
Identities = 245/1145 (21%), Positives = 465/1145 (40%), Gaps = 194/1145 (16%)
Query: 294 MMFSEDEALCVVDLLKEKSGVIQDALKKSSK--GELTTLIHQLQEKDKLLAAVKE---DA 348
M EDE + ++ +++ +K S+ E L QLQ + +L A +E
Sbjct: 854 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRL 913
Query: 349 AATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNK---IHVSYQETQQMQ 405
AA K +++ EM E +DR L+ E + + +E + +
Sbjct: 914 AAKKQELEEILHEMEARLEEE-------EDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966
Query: 406 MKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEK 465
K Q + EA+I L+ E ++ D +K S E L + + L L E+
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQ--------NNKLSKERKLLEERISDLTTNLAEE 1018
Query: 466 TGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRK----------RTAEHEAAQ 515
K + K E ++L+V+L++ E+ +E++ RK + A+ +A
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1078
Query: 516 QDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQL----------MESEQKRVNKEE 565
+L+ + KE E+Q+ ++L D + K +++ +L ++SE+ NK E
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138
Query: 566 SLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEK-DKQIKQTEDSLA 624
Q +D+ E+ EALK +++ A Q E+ V+ + D++ + E +
Sbjct: 1139 K---QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195
Query: 625 SERDRLTSKEEELKDIQNMNFLLKAEVQK-LQALANEQAAAAHELEKMQQSVYVKDDKIR 683
R + EEL + KA + K Q L E A A EL + Q+ + K +
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255
Query: 684 LLEEQLQHEISNKMEEFKI----LNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQE 739
LE Q+Q E+ +K + + LND+ L++EV+ + +++E K + ++ K +
Sbjct: 1256 KLEAQVQ-ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI--KLAKDVAS 1312
Query: 740 KDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEV-QDLKAKQNDQ--------- 789
+L+ +ELL+ Q +L + E +SL ++ ++++AKQN +
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 790 --------VSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKAL 841
FAS VE L++ +I+++ + E + EKT L+QE+ L
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432
Query: 842 KEEIGNVQ-----LEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKW 896
++ N + LEK Q+ + E +N+ ++ + +A EKE + +
Sbjct: 1433 VVDLDNQRQLVSNLEKKQR-KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 897 LQD-------LQEENESLKAHVQEVAQ---------HNLKEASSA--SQFEELEIVLKEK 938
L++ L+ N+ LKA ++++ H L+++ A +Q EE++ L+E
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 939 ENELK------------------RLEAMLKERESDLSSKTQLLQ--------DVQDENK- 971
E+EL+ + E L+ R+ K + LQ +++DE K
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1611
Query: 972 -----LFKSQIE-QLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLK---DAV 1022
K ++E LK Q S+ EE +K + + + ++ EL+ + D +
Sbjct: 1612 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671
Query: 1023 EHQRKKNNERQQQVEA------------------VELEAKEVLKKLFPKVSVPSNLS--- 1061
K+N ++ + +EA +LE +E+ ++L +S + L
Sbjct: 1672 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1731
Query: 1062 -------------YGEWLHGFEKKAKECMAGTSGSEEV------------------KVLE 1090
E E + T +E++ + LE
Sbjct: 1732 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1791
Query: 1091 HKLKEA-DEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQM 1149
+ KE ++H + K+KS +A E + +L+ VEQE + + + K++
Sbjct: 1792 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1851
Query: 1150 QSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETL 1209
+ E E + + E + L+ +LE+AE E R+L+ +L+E
Sbjct: 1852 KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1911
Query: 1210 TKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSV 1269
E + L + ++ + S + +G VIEN+D S E E +T
Sbjct: 1912 ESNEAMGREVNALKSKLRRGNET-SFVPS---RRSGGRRVIENADGSEE----ETDTRDA 1963
Query: 1270 SLNQT 1274
N T
Sbjct: 1964 DFNGT 1968
Score = 131 bits (329), Expect = 5e-30
Identities = 150/711 (21%), Positives = 325/711 (45%), Gaps = 68/711 (9%)
Query: 609 IAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHEL 668
+ ++++++ ED L ++R E ELK+++ + L E LQ + E
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 669 EKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKD 728
E+M+ + K ++ E++ HE+ ++EE + D+ + L++E +K+ Q D
Sbjct: 907 EEMRVRLAAKKQEL----EEILHEMEARLEEEE---DRGQQLQAERKKM-----AQQMLD 954
Query: 729 VVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQND 788
+ EQ+E+ +E + +E++ T ++ E+E+ + +N+ L+KE + L+ + +D
Sbjct: 955 LEEQLEE--EEAARQKLQLEKV--TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1010
Query: 789 QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEI-GN 847
+ + EE K + + K +S+ LE L K +EK+ +QE++ LK ++ G+
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK---EEKS----RQELEKLKRKLEGD 1063
Query: 848 VQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESL 907
Q + +++ EL+ L KEE++ A L+++ N K +++L+ L
Sbjct: 1064 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1123
Query: 908 KAHV-QEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDV 966
+ + E A N E EELE + E E+ L + R T L + +
Sbjct: 1124 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1183
Query: 967 QDENKLFKSQIEQLKQQNYQQASSFPPHEELLK-----------VISEREKEISGLWNEL 1015
+E + ++Q+++++Q++ Q E K + + +++G L
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1243
Query: 1016 DSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSN--LSYGEWLHGFEKKA 1073
K VEH++KK + Q++++ + + +L KV N S L+ E KA
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303
Query: 1074 KECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEEN 1133
+ +++V L +L++ E LLQ E + +V + R +E+E N
Sbjct: 1304 IKL------AKDVASLSSQLQDTQE---LLQEETRQKLNVSTKL--------RQLEEERN 1346
Query: 1134 KWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKD----IENLRREREHLEMELEKAEM 1189
+ ++DE + + ++ ++ +L + + +D +E L ++ + E+E
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 1190 ---ERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGD 1246
E++ ++ + K +L + L L + + ++++ +L K Q+ + + + +
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL---LAEEKNI 1463
Query: 1247 TTVIENSDVSPETESSEKETMSVSLNQTV---TQLQQLLQAVNQQLTKEKE 1294
++ + E E+ EKET ++SL + + + ++ L+ N+ L E E
Sbjct: 1464 SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME 1514
Score = 73.9 bits (180), Expect = 9e-13
Identities = 137/691 (19%), Positives = 284/691 (41%), Gaps = 110/691 (15%)
Query: 38 LAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQV 97
L + + E+ + + D++ E K+N ++ I N+ SDS+ +DF
Sbjct: 1338 LRQLEEERNSLQDQLDEEM-EAKQNLERHISTLNIQLSDSKKKLQDF------------- 1383
Query: 98 APVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSE 157
T ++ E KK+ +K+ L +Q +++ A + + TK
Sbjct: 1384 -------ASTVEALEEGKKRFQKEIENLTQQYEEKAAA-------YDKLEKTKNRLQQEL 1429
Query: 158 AAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQK 217
Q++ + + + +K + L+ K + +K + +A +++++
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK-------NISSKYADERDRAEAEAREKE 1482
Query: 218 TENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLL--KPDQVEGIQKSGTKKLKTET 275
T+ + + L A + + + + + K E+ DL+ K D + + + K ET
Sbjct: 1483 TKALSLARALEEA---LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539
Query: 276 DKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQ 335
E +KT + ++ L + K + V ALK + +L Q +
Sbjct: 1540 QME-----------EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588
Query: 336 EKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIH 395
EK + L + + + E+ E+++ + K G L+ + I
Sbjct: 1589 EKRRQL----------QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1638
Query: 396 VSYQETQQMQMKFQQVRE-QMEAEIAHLKQENGILRDAVSNTTNQLESKQ---SAELNKL 451
+ +Q++ Q+++ Q E E A RD + T + E K A+L +L
Sbjct: 1639 GREEAIKQLRKLQAQMKDFQRELEDARAS------RDEIFATAKENEKKAKSLEADLMQL 1692
Query: 452 RQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQL--KVQLQEAERRWEEVQSYIRKRTA 509
++D A E K L++EE+ AE+ A+ L + LQ+ +RR E R A
Sbjct: 1693 QEDLA--AAERARKQADLEKEEL----AEELASSLSGRNALQDEKRRLE-------ARIA 1739
Query: 510 EHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQM 569
+ E ++ Q A + V+ + QQ EQ L + +E+ K ES +
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRK----------ATQQAEQ-LSNELATERSTAQKNESARQ 1788
Query: 570 QVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDR 629
Q++ QN+ L++++ + + ++ +++ A L IA+ ++Q++Q +
Sbjct: 1789 QLE---RQNKELRSKLHEMEGAVKSKFKSTIAA--LEAKIAQLEEQVEQEAREKQAATKS 1843
Query: 630 LTSKEEELKDIQNMNFLLKAEVQKLQALANEQA----AAAHELEKMQQSVYVKDDKIRLL 685
L K+++LK+I L + +K+ EQA A +L++ + + +I
Sbjct: 1844 LKQKDKKLKEI----LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1899
Query: 686 EEQLQHEISNKMEEFKILNDQNKALKSEVQK 716
+LQ E+ E + + + ALKS++++
Sbjct: 1900 RRKLQRELDEATESNEAMGREVNALKSKLRR 1930
Score = 50.1 bits (118), Expect = 1e-05
Identities = 56/282 (19%), Positives = 119/282 (42%), Gaps = 37/282 (13%)
Query: 1026 RKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEE 1085
RK +RQQQ+ A+++ + L L +W F K K + T EE
Sbjct: 803 RKAFAKRQQQLTAMKVIQRNCAAYL--------KLRNWQWWRLFTK-VKPLLQVTRQEEE 853
Query: 1086 VKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKT 1145
++ E +L++ E QK + +++ E K +E +
Sbjct: 854 MQAKEDELQKTKERQ---------------------QKAENELKELEQKHSQLTEEKNLL 892
Query: 1146 IKQMQSS---FTSSEQELERLRSENKDIENLRRERE-HLEMELEKAEM---ERSTYVTEV 1198
+Q+Q+ + +E+ RL ++ +++E + E E LE E ++ + ER ++
Sbjct: 893 QEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQM 952
Query: 1199 RELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPE 1258
+L+ QL E + Q E+ + K + + ++ + K + + ++E
Sbjct: 953 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT 1012
Query: 1259 TESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
T +E+E + +L + + + ++ + +L KE++ Q LE
Sbjct: 1013 TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1054
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 163 bits (413), Expect = 9e-40
Identities = 245/1145 (21%), Positives = 465/1145 (40%), Gaps = 194/1145 (16%)
Query: 294 MMFSEDEALCVVDLLKEKSGVIQDALKKSSK--GELTTLIHQLQEKDKLLAAVKE---DA 348
M EDE + ++ +++ +K S+ E L QLQ + +L A +E
Sbjct: 861 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRL 920
Query: 349 AATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNK---IHVSYQETQQMQ 405
AA K +++ EM E +DR L+ E + + +E + +
Sbjct: 921 AAKKQELEEILHEMEARLEEE-------EDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973
Query: 406 MKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEK 465
K Q + EA+I L+ E ++ D +K S E L + + L L E+
Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQ--------NNKLSKERKLLEERISDLTTNLAEE 1025
Query: 466 TGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRK----------RTAEHEAAQ 515
K + K E ++L+V+L++ E+ +E++ RK + A+ +A
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1085
Query: 516 QDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQL----------MESEQKRVNKEE 565
+L+ + KE E+Q+ ++L D + K +++ +L ++SE+ NK E
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145
Query: 566 SLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEK-DKQIKQTEDSLA 624
Q +D+ E+ EALK +++ A Q E+ V+ + D++ + E +
Sbjct: 1146 K---QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202
Query: 625 SERDRLTSKEEELKDIQNMNFLLKAEVQK-LQALANEQAAAAHELEKMQQSVYVKDDKIR 683
R + EEL + KA + K Q L E A A EL + Q+ + K +
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262
Query: 684 LLEEQLQHEISNKMEEFKI----LNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQE 739
LE Q+Q E+ +K + + LND+ L++EV+ + +++E K + ++ K +
Sbjct: 1263 KLEAQVQ-ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI--KLAKDVAS 1319
Query: 740 KDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEV-QDLKAKQNDQ--------- 789
+L+ +ELL+ Q +L + E +SL ++ ++++AKQN +
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 790 --------VSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKAL 841
FAS VE L++ +I+++ + E + EKT L+QE+ L
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439
Query: 842 KEEIGNVQ-----LEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKW 896
++ N + LEK Q+ + E +N+ ++ + +A EKE + +
Sbjct: 1440 VVDLDNQRQLVSNLEKKQR-KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 897 LQD-------LQEENESLKAHVQEVAQ---------HNLKEASSA--SQFEELEIVLKEK 938
L++ L+ N+ LKA ++++ H L+++ A +Q EE++ L+E
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 939 ENELK------------------RLEAMLKERESDLSSKTQLLQ--------DVQDENK- 971
E+EL+ + E L+ R+ K + LQ +++DE K
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1618
Query: 972 -----LFKSQIE-QLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLK---DAV 1022
K ++E LK Q S+ EE +K + + + ++ EL+ + D +
Sbjct: 1619 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Query: 1023 EHQRKKNNERQQQVEA------------------VELEAKEVLKKLFPKVSVPSNLS--- 1061
K+N ++ + +EA +LE +E+ ++L +S + L
Sbjct: 1679 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1738
Query: 1062 -------------YGEWLHGFEKKAKECMAGTSGSEEV------------------KVLE 1090
E E + T +E++ + LE
Sbjct: 1739 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1798
Query: 1091 HKLKEA-DEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQM 1149
+ KE ++H + K+KS +A E + +L+ VEQE + + + K++
Sbjct: 1799 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1858
Query: 1150 QSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETL 1209
+ E E + + E + L+ +LE+AE E R+L+ +L+E
Sbjct: 1859 KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1918
Query: 1210 TKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSV 1269
E + L + ++ + S + +G VIEN+D S E E +T
Sbjct: 1919 ESNEAMGREVNALKSKLRRGNET-SFVPS---RRSGGRRVIENADGSEE----ETDTRDA 1970
Query: 1270 SLNQT 1274
N T
Sbjct: 1971 DFNGT 1975
Score = 131 bits (329), Expect = 5e-30
Identities = 150/711 (21%), Positives = 325/711 (45%), Gaps = 68/711 (9%)
Query: 609 IAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHEL 668
+ ++++++ ED L ++R E ELK+++ + L E LQ + E
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 669 EKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKD 728
E+M+ + K ++ E++ HE+ ++EE + D+ + L++E +K+ Q D
Sbjct: 914 EEMRVRLAAKKQEL----EEILHEMEARLEEEE---DRGQQLQAERKKM-----AQQMLD 961
Query: 729 VVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQND 788
+ EQ+E+ +E + +E++ T ++ E+E+ + +N+ L+KE + L+ + +D
Sbjct: 962 LEEQLEE--EEAARQKLQLEKV--TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1017
Query: 789 QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEI-GN 847
+ + EE K + + K +S+ LE L K +EK+ +QE++ LK ++ G+
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK---EEKS----RQELEKLKRKLEGD 1070
Query: 848 VQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESL 907
Q + +++ EL+ L KEE++ A L+++ N K +++L+ L
Sbjct: 1071 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1130
Query: 908 KAHV-QEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDV 966
+ + E A N E EELE + E E+ L + R T L + +
Sbjct: 1131 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1190
Query: 967 QDENKLFKSQIEQLKQQNYQQASSFPPHEELLK-----------VISEREKEISGLWNEL 1015
+E + ++Q+++++Q++ Q E K + + +++G L
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250
Query: 1016 DSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSN--LSYGEWLHGFEKKA 1073
K VEH++KK + Q++++ + + +L KV N S L+ E KA
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310
Query: 1074 KECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEEN 1133
+ +++V L +L++ E LLQ E + +V + R +E+E N
Sbjct: 1311 IKL------AKDVASLSSQLQDTQE---LLQEETRQKLNVSTKL--------RQLEEERN 1353
Query: 1134 KWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKD----IENLRREREHLEMELEKAEM 1189
+ ++DE + + ++ ++ +L + + +D +E L ++ + E+E
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413
Query: 1190 ---ERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGD 1246
E++ ++ + K +L + L L + + ++++ +L K Q+ + + + +
Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL---LAEEKNI 1470
Query: 1247 TTVIENSDVSPETESSEKETMSVSLNQTV---TQLQQLLQAVNQQLTKEKE 1294
++ + E E+ EKET ++SL + + + ++ L+ N+ L E E
Sbjct: 1471 SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME 1521
Score = 73.9 bits (180), Expect = 9e-13
Identities = 137/691 (19%), Positives = 284/691 (41%), Gaps = 110/691 (15%)
Query: 38 LAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQV 97
L + + E+ + + D++ E K+N ++ I N+ SDS+ +DF
Sbjct: 1345 LRQLEEERNSLQDQLDEEM-EAKQNLERHISTLNIQLSDSKKKLQDF------------- 1390
Query: 98 APVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSE 157
T ++ E KK+ +K+ L +Q +++ A + + TK
Sbjct: 1391 -------ASTVEALEEGKKRFQKEIENLTQQYEEKAAA-------YDKLEKTKNRLQQEL 1436
Query: 158 AAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQK 217
Q++ + + + +K + L+ K + +K + +A +++++
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK-------NISSKYADERDRAEAEAREKE 1489
Query: 218 TENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLL--KPDQVEGIQKSGTKKLKTET 275
T+ + + L A + + + + + K E+ DL+ K D + + + K ET
Sbjct: 1490 TKALSLARALEEA---LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546
Query: 276 DKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQ 335
E +KT + ++ L + K + V ALK + +L Q +
Sbjct: 1547 QME-----------EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595
Query: 336 EKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIH 395
EK + L + + + E+ E+++ + K G L+ + I
Sbjct: 1596 EKRRQL----------QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1645
Query: 396 VSYQETQQMQMKFQQVRE-QMEAEIAHLKQENGILRDAVSNTTNQLESKQ---SAELNKL 451
+ +Q++ Q+++ Q E E A RD + T + E K A+L +L
Sbjct: 1646 GREEAIKQLRKLQAQMKDFQRELEDARAS------RDEIFATAKENEKKAKSLEADLMQL 1699
Query: 452 RQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQL--KVQLQEAERRWEEVQSYIRKRTA 509
++D A E K L++EE+ AE+ A+ L + LQ+ +RR E R A
Sbjct: 1700 QEDLA--AAERARKQADLEKEEL----AEELASSLSGRNALQDEKRRLE-------ARIA 1746
Query: 510 EHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQM 569
+ E ++ Q A + V+ + QQ EQ L + +E+ K ES +
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRK----------ATQQAEQ-LSNELATERSTAQKNESARQ 1795
Query: 570 QVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDR 629
Q++ QN+ L++++ + + ++ +++ A L IA+ ++Q++Q +
Sbjct: 1796 QLE---RQNKELRSKLHEMEGAVKSKFKSTIAA--LEAKIAQLEEQVEQEAREKQAATKS 1850
Query: 630 LTSKEEELKDIQNMNFLLKAEVQKLQALANEQA----AAAHELEKMQQSVYVKDDKIRLL 685
L K+++LK+I L + +K+ EQA A +L++ + + +I
Sbjct: 1851 LKQKDKKLKEI----LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1906
Query: 686 EEQLQHEISNKMEEFKILNDQNKALKSEVQK 716
+LQ E+ E + + + ALKS++++
Sbjct: 1907 RRKLQRELDEATESNEAMGREVNALKSKLRR 1937
Score = 50.1 bits (118), Expect = 1e-05
Identities = 56/282 (19%), Positives = 119/282 (42%), Gaps = 37/282 (13%)
Query: 1026 RKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEE 1085
RK +RQQQ+ A+++ + L L +W F K K + T EE
Sbjct: 810 RKAFAKRQQQLTAMKVIQRNCAAYL--------KLRNWQWWRLFTK-VKPLLQVTRQEEE 860
Query: 1086 VKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKT 1145
++ E +L++ E QK + +++ E K +E +
Sbjct: 861 MQAKEDELQKTKERQ---------------------QKAENELKELEQKHSQLTEEKNLL 899
Query: 1146 IKQMQSS---FTSSEQELERLRSENKDIENLRRERE-HLEMELEKAEM---ERSTYVTEV 1198
+Q+Q+ + +E+ RL ++ +++E + E E LE E ++ + ER ++
Sbjct: 900 QEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQM 959
Query: 1199 RELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPE 1258
+L+ QL E + Q E+ + K + + ++ + K + + ++E
Sbjct: 960 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT 1019
Query: 1259 TESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
T +E+E + +L + + + ++ + +L KE++ Q LE
Sbjct: 1020 TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1061
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 160 bits (404), Expect = 1e-38
Identities = 216/1072 (20%), Positives = 468/1072 (43%), Gaps = 137/1072 (12%)
Query: 317 DALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ-------------EMM 363
+A +K + ++ TL+ + + + A + A ++RC QL + E
Sbjct: 871 EAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERA 930
Query: 364 TEKERSNVVIT----RMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQM---E 416
++E N +T +++D L+K+ + + + +E + K + + E+M +
Sbjct: 931 EDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 990
Query: 417 AEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQK 476
IA L +E L++A T + L++++ ++N L + +L ++ + G L+QE+
Sbjct: 991 ETIAKLTKEKKALQEAHQQTLDDLQAEED-KVNTLTKAKIKLEQQVDDLEGSLEQEK--- 1046
Query: 477 KNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKL 536
++++ L+ A+R+ E ++ T + E +Q L K KE E+ L SK+
Sbjct: 1047 --------KIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKI 1098
Query: 537 TDTLVSKQQLEQRLMQLM--------ESEQKRVNKEESLQMQVQDILEQNEALKAQIQQF 588
D QL++++ +L E E +R ++ ++ + Q D+ + E + ++++
Sbjct: 1099 EDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKA-EKQRSDLSRELEEISERLEEA 1157
Query: 589 HSQIAAQTSASVLAE-ELHKVIAEKDKQIKQTEDSLASER----DRLTSKEEELKDIQNM 643
+AQ + E E K+ + ++ Q E + A+ R D + E++ ++Q +
Sbjct: 1158 GGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRV 1217
Query: 644 NFLL-------KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNK 696
L K E+ L + + A LEKM +++ + +I+ EE+ Q I++
Sbjct: 1218 KQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDL 1277
Query: 697 MEEFKILNDQNKALKSEVQKLQTLVSE-----QPNKDVVEQMEKCIQEKDEKLKTVEELL 751
+ L ++ ++ + TLVS+ Q +E++++ ++E+ + + L
Sbjct: 1278 TAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHAL 1337
Query: 752 ETG------LIQVATKEEELNA-IRTENSSLTKEVQDLKAK-QNDQVSFASLVEELKKVI 803
++ L + +E+E A ++ S EV + K + D + +EE KK +
Sbjct: 1338 QSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKL 1397
Query: 804 HEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQ-----LEKAQQ--- 855
+ +++ EE +EA K A+ EKT Q L+ E++ L ++ L+K Q+
Sbjct: 1398 AQ---RLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFD 1454
Query: 856 ---LSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQ 912
K +E L+ +++ ++ L + + + L+ L+ EN++L+ Q
Sbjct: 1455 KILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQ---Q 1511
Query: 913 EVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKL 972
E++ + A + ELE + K+ E E L+A L+E E+ L + + +Q E
Sbjct: 1512 EISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQ 1571
Query: 973 FKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKN--- 1029
KS++++ + ++ + ++++ + + E+ S DA+ ++K
Sbjct: 1572 VKSEVDRKIAEKDEEIDQMKRNH--IRIVESMQSTLDA---EIRSRNDAIRLKKKMEGDL 1626
Query: 1030 NERQQQVEAVELEAKEVLK------------KLFPKVSVPSNLSYGEWLHGFEKKA---- 1073
NE + Q+ A E L+ +L ++ S E L E++A
Sbjct: 1627 NEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQ 1686
Query: 1074 ---KECMAGTSGSEEV-KVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVE 1129
+E A +E K+ E +L +A E LL + + L T+ +KL+ +
Sbjct: 1687 AEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQ----NTSLINTK---KKLETDIS 1739
Query: 1130 QEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEM 1189
Q + + + + E+ ++ + + T + E L+ E +L R +++LE
Sbjct: 1740 QIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQ------- 1792
Query: 1190 ERSTYVTEVRELKAQLNET-LTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTT 1248
V++L+ +L+E L+ + + QK+ + + + +E Q + V+A
Sbjct: 1793 -------TVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLR 1845
Query: 1249 VIEN--SDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQV 1298
E +++ +TE K + L V +LQ +++ +Q + +E V
Sbjct: 1846 KHERKVKELTYQTEEDRKNIL--RLQDLVDKLQAKVKSYKRQAEEAEEQSNV 1895
Score = 146 bits (369), Expect = 1e-34
Identities = 229/1152 (19%), Positives = 500/1152 (43%), Gaps = 166/1152 (14%)
Query: 180 KVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDN 239
K++ L+ ++ ++ + +E +++ K +K+++ E V L+ + L
Sbjct: 839 KIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVT--LMQEKNDLQLQVQ 896
Query: 240 ADSSPVVDKREVID-LLKPD-QVEGIQKSGTKKLKTETDKENAEV-----KFKDFLLSLK 292
A++ + D E D L+K Q+E K T++ + E ++ NAE+ K +D LK
Sbjct: 897 AEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDE-EEINAELTAKKRKLEDECSELK 955
Query: 293 TMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATK 352
+ +D L + + KEK +++ ++ L ++ D+ +A + ++ A +
Sbjct: 956 KDI--DDLELTLAKVEKEKH---------ATENKVKNLTEEMAGLDETIAKLTKEKKALQ 1004
Query: 353 DRCKQLTQEMMTEKERSNVVIT-------RMKDRIGTLEKEHNV------FQNKIHVSYQ 399
+ +Q ++ E+++ N + ++ D G+LE+E + + K+ +
Sbjct: 1005 EAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLK 1064
Query: 400 ETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLV 459
Q+ M + ++Q++ ++ + E L+ + + E +L K ++ +
Sbjct: 1065 LAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIED-----EQALGMQLQKKIKELQARI 1119
Query: 460 NELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYI-------RKRTAEHE 512
EL E+ ++ E + AE+ + L +L+E R EE +KR AE +
Sbjct: 1120 EELEEE---IEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQ 1176
Query: 513 AAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQ 572
++DL+ + E +L K D++ +L +++ L +QK ++ ++M++
Sbjct: 1177 KMRRDLEEATLQHEATAATLRKKHADSVA---ELGEQIDNLQRVKQKLEKEKSEMKMEID 1233
Query: 573 DILEQNEAL---KAQIQQFHSQIAAQTSA-SVLAEELHKVIAEKDKQIK--QTEDSLAS- 625
D+ E + K +++ + Q S EE ++I + Q QTE S
Sbjct: 1234 DLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSR 1293
Query: 626 ---ERDRLTS-----KEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYV 677
E+D L S K+ + I+ + L+ E++ ALA+ ++ H+ +
Sbjct: 1294 QLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCD-------- 1345
Query: 678 KDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCI 737
LL EQ + E K E + ++ N + K +T ++ E++E+
Sbjct: 1346 ------LLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQR-----TEELEEAK 1394
Query: 738 QEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK----QNDQVSFA 793
++ ++L+ EE +E + A+ E+ ++ E L +V+ A Q +F
Sbjct: 1395 KKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFD 1454
Query: 794 SLVEELKKVIHEKDGKIKSVEE---LLEAELLKVANKEKTVQD----LKQEIKALKEEIG 846
++ E K+ E ++++ ++ L EL K+ N + D LK+E K L++EI
Sbjct: 1455 KILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEIS 1514
Query: 847 NVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENES 906
++ + A+ ++ EL+ + K E++ + ++A LEE E L + + +Q E
Sbjct: 1515 DLTEQIAEG---GKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQ 1571
Query: 907 LKAHVQ-----------EVAQHNLKEASSASQFEELEIVLKEKENELKR-LEAMLKERES 954
+K+ V ++ +++++ S + EI + LK+ +E L E E
Sbjct: 1572 VKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEI 1631
Query: 955 DLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNE 1014
L+ ++ + + +++ LK + E+L + ++ E+ + L E
Sbjct: 1632 QLNHANRMAAEAL---RNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAE 1688
Query: 1015 LDSLKDAVEHQRKKNNERQQQV----EAVELEAKEVLKKLFPKVSVPSNLSY--GEW--- 1065
++ L+ +E + +Q++ E V+L + + K + +++S GE
Sbjct: 1689 IEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDI 1748
Query: 1066 ---LHGFEKKAKECMAGTSGSEE----------------------VKVLEHKLKEADEMH 1100
E+KAK+ + + E VK L+H+L EA+++
Sbjct: 1749 IQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLA 1808
Query: 1101 TLL-QLECEKYKSVLAETEGILQKLQ-RSVEQ----EENKWKVK-----VDESHKTIKQM 1149
+ + +K ++ + E EG ++ Q R+VE +++ KVK +E K I ++
Sbjct: 1809 LKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRL 1868
Query: 1150 QSSFTSSEQELERLRSENKDIE-----NLRREREHLEMELEKAEMERSTYVTEVRELKAQ 1204
Q + +++ + + ++ E NL + R ++ ELE+AE ++V +L+ +
Sbjct: 1869 QDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRR-IQHELEEAEERADIAESQVNKLRVK 1927
Query: 1205 LNETLTKLRTEQ 1216
E TK+ +E+
Sbjct: 1928 SREVHTKIISEE 1939
Score = 139 bits (350), Expect = 2e-32
Identities = 185/865 (21%), Positives = 369/865 (42%), Gaps = 107/865 (12%)
Query: 468 KLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKEN 527
+++ +++ ++ Q V+ + W ++ Y + + A + + + +
Sbjct: 802 RVEYQKMVERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSA---ETEKEMANMKE 858
Query: 528 EVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQ---DILEQNEALKAQ 584
E + +L T +++LE++++ LM+ ++ LQ+QVQ D L E Q
Sbjct: 859 EFEKTKEELAKTEAKRKELEEKMVTLMQ-------EKNDLQLQVQAEADSLADAEERCDQ 911
Query: 585 IQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEEL-KDIQNM 643
+ + Q+ A+ K + E+ + ++ L +++ +L + EL KDI ++
Sbjct: 912 LIKTKIQLEAKI----------KEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL 961
Query: 644 NFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKIL 703
L ++ A N+ E+ + +++ + + L+E Q + + E +
Sbjct: 962 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKV 1021
Query: 704 NDQNKA-LKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKE 762
N KA +K E Q S + K + +E+ ++ + LK +E +
Sbjct: 1022 NTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLD 1081
Query: 763 EELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELL 822
E+L E S L +++D +A L +L+K I E +I+ +EE +EAE
Sbjct: 1082 EKLKKKEFEMSGLQSKIEDEQA----------LGMQLQKKIKELQARIEELEEEIEAERA 1131
Query: 823 KVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQ-ELQNLLKGKEE---QMNT 878
A EK DL +E++ + E + + Q+ + K + E Q + + EE Q
Sbjct: 1132 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA 1191
Query: 879 MKAVLEEKEKD--------LANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEE 930
A L +K D + N + Q L++E +K + ++A + + + E+
Sbjct: 1192 TAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEK 1251
Query: 931 LEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQ-------DENKLFKSQIEQLKQQ 983
+ L+++ +E+K E + +DL+++ LQ DE SQ+ + KQ
Sbjct: 1252 MCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQA 1311
Query: 984 NYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEA 1043
QQ EEL + + E K S L + L S + + R++ E Q EA
Sbjct: 1312 FTQQI------EELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQ--------EA 1357
Query: 1044 KEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEV-KVLEHKLKEADEMHTL 1102
K L++ K +N +W +E A + T EE K L +L++A+E
Sbjct: 1358 KAELQRAMSK----ANSEVAQWRTKYETDA---IQRTEELEEAKKKLAQRLQDAEEHVEA 1410
Query: 1103 LQLEC---EKYKSVLA-ETEGI-------------LQKLQRSVEQEENKWKVKVDESHKT 1145
+ +C EK K L E E + L K QR+ ++ +WK K +E+H
Sbjct: 1411 VNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAE 1470
Query: 1146 IKQMQSSFTSSEQELERLRSENKD----IENLRREREHLEMELEKAEMERSTYVTEVREL 1201
++ Q S EL ++++ ++ +E L+RE ++L+ E+ S ++ E
Sbjct: 1471 LEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEI-------SDLTEQIAEG 1523
Query: 1202 KAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETES 1261
+++E + + E+ ++ L +A+ SLE + KI++ + ++ S+V +
Sbjct: 1524 GKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVK-SEVDRKIAE 1582
Query: 1262 SEKETMSVSLN--QTVTQLQQLLQA 1284
++E + N + V +Q L A
Sbjct: 1583 KDEEIDQMKRNHIRIVESMQSTLDA 1607
Score = 55.1 bits (131), Expect = 4e-07
Identities = 114/639 (17%), Positives = 268/639 (41%), Gaps = 77/639 (12%)
Query: 29 MKETLYDEVLAKQKREQKLIPTKTD----KKKAEKKKNKKKEIQNGNLHES--------- 75
+K L +E+ AK L ++ D +++ E+++ K E+Q +
Sbjct: 1319 LKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTK 1378
Query: 76 -DSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVI---- 130
+++++ R +L +A ++ +V ++ +K +++ + +E+ +I
Sbjct: 1379 YETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVER 1438
Query: 131 ----------KESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
K+ + KI + + T S+ + K KN ++ +
Sbjct: 1439 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQ 1498
Query: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
+ETL +K + + T+Q + GK+ +K K + V ++ + A ++ A
Sbjct: 1499 LETLKRENKNLQQ-EISDLTEQIAEGGKRIHELEKIKKQ-VEQEKSELQAA-----LEEA 1551
Query: 241 DSSPVVDKREVIDL-LKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSED 299
++S ++ +++ + L+ +QV KS + E D+E ++K ++ + +++M + D
Sbjct: 1552 EASLEHEEGKILRIQLELNQV----KSEVDRKIAEKDEEIDQMK-RNHIRIVESMQSTLD 1606
Query: 300 EALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLT 359
+ + ++ I+ LKK +G+L + QL +++ A + T+ K T
Sbjct: 1607 AEI------RSRNDAIR--LKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKD-T 1657
Query: 360 QEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEI 419
Q + + RS +K+++ +E+ N+ Q +I + T + + +++ EQ +
Sbjct: 1658 QLHLDDALRSQ---EDLKEQLAMVERRANLLQAEIE-ELRATLEQTERSRKIAEQELLDA 1713
Query: 420 AHLKQENGILRDAVSNTTNQLE---SKQSAELNKLRQ--------------DYARLVNEL 462
+ Q ++ NT +LE S+ E+ + Q D A + EL
Sbjct: 1714 SERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEEL 1773
Query: 463 TEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRW-----EEVQSYIRKRTAEHEAAQQD 517
++ E KKN EQ L+ +L EAE+ +++Q + R E E +
Sbjct: 1774 KKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK-LEARVRELEGEVES 1832
Query: 518 LQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQ 577
Q + V ++ K+ + ++ + +++L + K K +S + Q ++ EQ
Sbjct: 1833 EQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQ 1892
Query: 578 NEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQI 616
+ ++ ++ ++ + +AE + K +++
Sbjct: 1893 SNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKSREV 1931
Score = 38.5 bits (88), Expect = 0.042
Identities = 39/214 (18%), Positives = 90/214 (42%), Gaps = 10/214 (4%)
Query: 1092 KLKEADEMHTLLQLECEKYKSVLAETEGILQKLQR---SVEQEENKWKVKVDESHKTIKQ 1148
K E ++ ++ E EK K LA+TE ++L+ ++ QE+N +++V ++
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLAD 904
Query: 1149 MQSSFTSSEQELERLRSENKDIENLRREREHLEMEL--EKAEMERSTYVTEVRELKAQLN 1206
+ + +L ++ K++ + E + EL +K ++E E ELK ++
Sbjct: 905 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLE-----DECSELKKDID 959
Query: 1207 ETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKET 1266
+ L + E+ + + + + I K + ++ + + +E
Sbjct: 960 DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED 1019
Query: 1267 MSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
+L + +L+Q + + L +EK+ LE
Sbjct: 1020 KVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLE 1053
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 160 bits (404), Expect = 1e-38
Identities = 208/1026 (20%), Positives = 457/1026 (44%), Gaps = 139/1026 (13%)
Query: 308 LKEKSGVIQDALKKSS------KGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ- 360
+KE+ I+D L KS + ++ TL+ + + + A E A ++RC QL +
Sbjct: 858 MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKT 917
Query: 361 ------------EMMTEKERSNVVIT----RMKDRIGTLEKEHNVFQNKIHVSYQETQQM 404
E ++E N +T +++D L+K+ + + + +E
Sbjct: 918 KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 977
Query: 405 QMKFQQVREQM---EAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE 461
+ K + + E+M + IA L +E L++A T + L++++ ++N L + +L +
Sbjct: 978 ENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED-KVNTLTKAKIKLEQQ 1036
Query: 462 LTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSK 521
+ + G L+QE+ +L++ L+ A+R+ E ++ + E +Q L K
Sbjct: 1037 VDDLEGSLEQEK-----------KLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEK 1085
Query: 522 FVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLM--------ESEQKRVNKEESLQMQVQD 573
KE E+ +L SK+ D QL++++ +L E E +R ++ ++ + Q D
Sbjct: 1086 LKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA-EKQRSD 1144
Query: 574 ILEQNEALKAQIQQFHSQIAAQTSASVLAE-ELHKVIAEKDKQIKQTEDSLASER----D 628
+ + E + ++++ +AQ + E E K+ + ++ Q E + A+ R D
Sbjct: 1145 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204
Query: 629 RLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQ 688
+ E++ ++Q + L+ E +++ ++ A+ + K + ++ + R LE+Q
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNL---EKMCRTLEDQ 1261
Query: 689 LQHEISNKMEEFKILND---QNKALKSE-------VQKLQTLVSE--QPNKDVVEQMEKC 736
L S + E+ +++ND Q L++E + + + LVS+ + + +Q+E+
Sbjct: 1262 LSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEEL 1321
Query: 737 IQEKDEKLKTVEELL--------ETGLIQVATKEEELNAIRTEN--SSLTKEVQDLKAK- 785
++ +E++K L + L++ +EE+ + + S EV + K
Sbjct: 1322 KRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY 1381
Query: 786 QNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEI 845
+ D + +EE KK + + ++++ EE +EA K A+ EKT Q L+ E++ L +
Sbjct: 1382 ETDAIQRTEELEEAKKKLAQ---RLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDL---M 1435
Query: 846 GNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTG----------- 894
+V+ A ++ K + +L +++ A LE +K+ + G
Sbjct: 1436 LDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYE 1495
Query: 895 ---KWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKE 951
L+ L+ EN++L+ QE++ + A + ELE + K+ E E L+A L+E
Sbjct: 1496 ESLDQLETLKRENKNLQ---QEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEE 1552
Query: 952 RESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGL 1011
E+ L + + +Q E KS++++ + ++ + ++++ + +
Sbjct: 1553 AEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNH--IRIVESMQSTLDA- 1609
Query: 1012 WNELDSLKDAVEHQRKKN---NERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHG 1068
E+ S DA+ ++K NE + Q+ A E L+ G
Sbjct: 1610 --EIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNY-------------RNTQG 1654
Query: 1069 FEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSV 1128
K + + S+E L+ +L + LLQ E E+ ++ L +TE + ++
Sbjct: 1655 ILKDTQIHLDDALRSQE--DLKEQLAMVERRANLLQAEIEELRATLEQTE----RSRKIA 1708
Query: 1129 EQEENKWKVKVDESH-------KTIKQMQSSFTSSEQELERLRSENKDI-ENLRREREHL 1180
EQE +V H T K++++ + + E+E + E ++ E ++
Sbjct: 1709 EQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDA 1768
Query: 1181 EMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKI 1240
M E+ + E+ T + +K + +T+ L+ +E +++A L ++ ++ +++++
Sbjct: 1769 AMMAEELKKEQDT-SAHLERMKKNMEQTVKDLQLRLDEAEQLA--LKGGKKQIQKLEARV 1825
Query: 1241 VKAAGD 1246
+ G+
Sbjct: 1826 RELEGE 1831
Score = 144 bits (362), Expect = 7e-34
Identities = 222/1141 (19%), Positives = 492/1141 (43%), Gaps = 144/1141 (12%)
Query: 180 KVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDN 239
K++ L+ ++ ++ + +E Q+ K+ +K+++ E V L+ + L
Sbjct: 841 KIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVT--LLKEKNDLQLQVQ 898
Query: 240 ADSSPVVDKREVID-LLKPD-QVEGIQKSGTKKLKTETDKENAEV-----KFKDFLLSLK 292
A++ + D E D L+K Q+E K T++ + E ++ NAE+ K +D LK
Sbjct: 899 AEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDE-EEINAELTAKKRKLEDECSELK 957
Query: 293 TMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATK 352
+ +D L + + KEK +++ ++ L ++ D+ +A + ++ A +
Sbjct: 958 KDI--DDLELTLAKVEKEKH---------ATENKVKNLTEEMAGLDETIAKLTKEKKALQ 1006
Query: 353 DRCKQLTQEMMTEKERSNVVIT-------RMKDRIGTLEKEHNV------FQNKIHVSYQ 399
+ +Q ++ E+++ N + ++ D G+LE+E + + K+ +
Sbjct: 1007 EAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLK 1066
Query: 400 ETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLV 459
Q+ M + ++Q++ ++ + E +SN +++E +Q+ + +L++ L
Sbjct: 1067 LAQESIMDIENEKQQLDEKLKKKEFE-------ISNLQSKIEDEQALGI-QLQKKIKELQ 1118
Query: 460 NELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYI-------RKRTAEHE 512
+ E +++ E + AE+ + L +L+E R EE +KR AE +
Sbjct: 1119 ARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQ 1178
Query: 513 AAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQ 572
++DL+ + E +L K D++ +L +++ L +QK ++ ++M++
Sbjct: 1179 KMRRDLEEATLQHEATAATLRKKHADSVA---ELGEQIDNLQRVKQKLEKEKSEMKMEID 1235
Query: 573 DILEQNEAL---KAQIQQFHSQIAAQTSA-SVLAEELHKVIAEKDKQIKQTEDSLASERD 628
D+ E + K +++ + Q S EE ++I + Q + +
Sbjct: 1236 DLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSR 1295
Query: 629 RLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQ 688
+L KE + + ++++L+ E+ A + L QS D LL EQ
Sbjct: 1296 QLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCD---LLREQ 1352
Query: 689 LQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVE 748
+ E +K E + L+ N + K +T ++ E++E+ ++ ++L+ E
Sbjct: 1353 YEEEQESKAELQRALSKANTEVAQWRTKYETDAIQR-----TEELEEAKKKLAQRLQAAE 1407
Query: 749 ELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK----QNDQVSFASLVEELKKVIH 804
E +E + A+ E+ ++ E L +V+ A Q +F ++ E K+
Sbjct: 1408 EHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCE 1467
Query: 805 EKDGKIKSVEE---LLEAELLKVANKEKTVQD----LKQEIKALKEEIGNVQLEKAQQLS 857
E ++++ ++ L EL K+ N + D LK+E K L++EI ++ + A+
Sbjct: 1468 ETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEG-- 1525
Query: 858 ITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQ----- 912
++ EL+ + K E++ ++A LEE E L + + +Q E +K+ V
Sbjct: 1526 -GKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAE 1584
Query: 913 ------EVAQHNLKEASSASQFEELEIVLKEKENELKR-LEAMLKERESDLSSKTQLLQD 965
++ +++++ S + EI + LK+ +E L E E L+ ++ +
Sbjct: 1585 KDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAE 1644
Query: 966 VQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQ 1025
+ +++ LK + E+L + ++ E+ + L E++ L+ +E
Sbjct: 1645 AL---RNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQT 1701
Query: 1026 RKKNNERQQQV----EAVELEAKEVLKKLFPKVSVPSNLSY--GEW------LHGFEKKA 1073
+ +Q++ E V+L + + K + +++S GE E+KA
Sbjct: 1702 ERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKA 1761
Query: 1074 KECMAGTSG-SEEVKV-------LEHKLKEADEMHTLLQLECEKY--------KSVLAET 1117
K+ + + +EE+K LE K ++ LQL ++ K + +
Sbjct: 1762 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKL 1821
Query: 1118 EGILQKLQRSVEQEENK-----------------WKVKVDESHKTIKQMQSSFTSSEQEL 1160
E +++L+ VE E+ + + +E K I ++Q + ++
Sbjct: 1822 EARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKV 1881
Query: 1161 ERLRSENKDIE-----NLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTE 1215
+ + + ++ E NL + R+ L+ ELE+AE ++V +L+ + E TK+ +E
Sbjct: 1882 KSYKRQAEEAEEQSNTNLAKFRK-LQHELEEAEERADIAESQVNKLRVKSREVHTKVISE 1940
Query: 1216 Q 1216
+
Sbjct: 1941 E 1941
Score = 95.1 bits (235), Expect = 4e-19
Identities = 123/611 (20%), Positives = 276/611 (45%), Gaps = 69/611 (11%)
Query: 712 SEVQKLQTLVSE--QPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIR 769
+E +K + E Q KD + + E +E +EK+ T+ + +QV + E L
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAE 908
Query: 770 TENSSLTKEVQDLKAKQNDQVSFASLVEEL-------KKVIHEKDGKIKSVEELLEAELL 822
L K L+AK + A EE+ K+ + ++ ++K + LE L
Sbjct: 909 ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 968
Query: 823 KVANK----EKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNT 878
KV + E V++L +E+ L E I + EK ++ Q+ + L+ +E+++NT
Sbjct: 969 KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKK---ALQEAHQQTLDDLQAEEDKVNT 1025
Query: 879 M---KAVLEEKEKDLANTGKWLQDLQEENESLKAHVQ---EVAQHNLKEASSASQFEELE 932
+ K LE++ DL + + + L+ + E K ++ ++AQ ++ + + Q +L+
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQ--QLD 1083
Query: 933 IVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFP 992
LK+KE E+ L++ +++ ++ L +Q + K +++IE+L+++ + +S
Sbjct: 1084 EKLKKKEFEISNLQSKIEDEQA-------LGIQLQKKIKELQARIEELEEEIEAERASRA 1136
Query: 993 PHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFP 1052
E+ +S +EIS L+ A Q + N +R+ + + + + +E
Sbjct: 1137 KAEKQRSDLSRELEEIS---ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE------- 1186
Query: 1053 KVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKS 1112
+ L + KK + +A E++ L+ ++ ++ + +++E + S
Sbjct: 1187 -----ATLQHEATAATLRKKHADSVAEL--GEQIDNLQRVKQKLEKEKSEMKMEIDDLAS 1239
Query: 1113 ---VLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKD 1169
+++ +G L+K+ R++E + ++ K K +E + I + + + RL++E+ +
Sbjct: 1240 NVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTA-------QRGRLQTESGE 1292
Query: 1170 IENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKA 1229
E+E L +L + + + ++ ELK QL E E + +A L +
Sbjct: 1293 FSRQLDEKEALVSQLSRG---KQAFTQQIEELKRQLEE-------EIKAKNALAHALQSS 1342
Query: 1230 QQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKET-MSVSLNQTVTQLQQLLQAVNQQ 1288
+ +L++ + + ++ + TE ++ T Q +L++ + + Q+
Sbjct: 1343 RHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1402
Query: 1289 LTKEKEHYQVL 1299
L +EH + +
Sbjct: 1403 LQAAEEHVEAV 1413
Score = 79.7 bits (195), Expect = 2e-14
Identities = 111/520 (21%), Positives = 228/520 (43%), Gaps = 84/520 (16%)
Query: 821 LLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQ----QLSITSKVQELQNLLKGKEE-- 874
LLK A EK + +K+E + +K+E+ + ++ + +++ + +LQ ++ + E
Sbjct: 845 LLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904
Query: 875 --------QMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSAS 926
Q+ K LE K K++ + +++ E + K +++ K+
Sbjct: 905 ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD----- 959
Query: 927 QFEELEIVL----KEK---ENELKRL-----------EAMLKERESDLSSKTQLLQDVQD 968
++LE+ L KEK EN++K L + KE+++ + Q L D+Q
Sbjct: 960 -IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQA 1018
Query: 969 E----NKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEH 1024
E N L K++I +L+QQ S ++L + ++++ G LK A E
Sbjct: 1019 EEDKVNTLTKAKI-KLEQQVDDLEGSLEQEKKLRMDLERAKRKLEG------DLKLAQES 1071
Query: 1025 QRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSG-S 1083
NE+QQ E ++ + E+ L K+ L +KK KE A
Sbjct: 1072 IMDIENEKQQLDEKLKKKEFEI-SNLQSKIEDEQALGI-----QLQKKIKELQARIEELE 1125
Query: 1084 EEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQ-KLQRSVEQEENKWKVKVDES 1142
EE++ +A++ + L E E+ L E G +++ + ++E K++ D
Sbjct: 1126 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE 1185
Query: 1143 HKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVREL- 1201
T++ ++ T ++ + + + I+NL+R ++ LE E + +ME + V +
Sbjct: 1186 EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVS 1245
Query: 1202 KAQ---------LNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIEN 1252
KA+ L + L++L++++ E+Q++ DL + L+ E+
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQ---------------TES 1290
Query: 1253 SDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKE 1292
+ S + + EKE + L++ Q ++ + +QL +E
Sbjct: 1291 GEFSRQLD--EKEALVSQLSRGKQAFTQQIEELKRQLEEE 1328
Score = 35.4 bits (80), Expect = 0.36
Identities = 39/221 (17%), Positives = 93/221 (42%), Gaps = 11/221 (4%)
Query: 1085 EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVE---QEENKWKVKVDE 1141
++K L + EM T+ + E +K K LA++E ++L+ + +E+N +++V
Sbjct: 841 KIKPLLKSAETEKEMATMKE-EFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQA 899
Query: 1142 SHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMEL--EKAEMERSTYVTEVR 1199
+ + + + +L ++ K++ + E + EL +K ++E E
Sbjct: 900 EAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLE-----DECS 954
Query: 1200 ELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPET 1259
ELK +++ L + E+ + + + + I K + ++ +
Sbjct: 955 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1014
Query: 1260 ESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
+ +E +L + +L+Q + + L +EK+ LE
Sbjct: 1015 DLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLE 1055
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 160 bits (404), Expect = 1e-38
Identities = 208/1026 (20%), Positives = 457/1026 (44%), Gaps = 139/1026 (13%)
Query: 308 LKEKSGVIQDALKKSS------KGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ- 360
+KE+ I+D L KS + ++ TL+ + + + A E A ++RC QL +
Sbjct: 858 MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKT 917
Query: 361 ------------EMMTEKERSNVVIT----RMKDRIGTLEKEHNVFQNKIHVSYQETQQM 404
E ++E N +T +++D L+K+ + + + +E
Sbjct: 918 KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 977
Query: 405 QMKFQQVREQM---EAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE 461
+ K + + E+M + IA L +E L++A T + L++++ ++N L + +L +
Sbjct: 978 ENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED-KVNTLTKAKIKLEQQ 1036
Query: 462 LTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSK 521
+ + G L+QE+ +L++ L+ A+R+ E ++ + E +Q L K
Sbjct: 1037 VDDLEGSLEQEK-----------KLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEK 1085
Query: 522 FVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLM--------ESEQKRVNKEESLQMQVQD 573
KE E+ +L SK+ D QL++++ +L E E +R ++ ++ + Q D
Sbjct: 1086 LKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA-EKQRSD 1144
Query: 574 ILEQNEALKAQIQQFHSQIAAQTSASVLAE-ELHKVIAEKDKQIKQTEDSLASER----D 628
+ + E + ++++ +AQ + E E K+ + ++ Q E + A+ R D
Sbjct: 1145 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204
Query: 629 RLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQ 688
+ E++ ++Q + L+ E +++ ++ A+ + K + ++ + R LE+Q
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNL---EKMCRTLEDQ 1261
Query: 689 LQHEISNKMEEFKILND---QNKALKSE-------VQKLQTLVSE--QPNKDVVEQMEKC 736
L S + E+ +++ND Q L++E + + + LVS+ + + +Q+E+
Sbjct: 1262 LSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEEL 1321
Query: 737 IQEKDEKLKTVEELL--------ETGLIQVATKEEELNAIRTEN--SSLTKEVQDLKAK- 785
++ +E++K L + L++ +EE+ + + S EV + K
Sbjct: 1322 KRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY 1381
Query: 786 QNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEI 845
+ D + +EE KK + + ++++ EE +EA K A+ EKT Q L+ E++ L +
Sbjct: 1382 ETDAIQRTEELEEAKKKLAQ---RLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDL---M 1435
Query: 846 GNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTG----------- 894
+V+ A ++ K + +L +++ A LE +K+ + G
Sbjct: 1436 LDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYE 1495
Query: 895 ---KWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKE 951
L+ L+ EN++L+ QE++ + A + ELE + K+ E E L+A L+E
Sbjct: 1496 ESLDQLETLKRENKNLQ---QEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEE 1552
Query: 952 RESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGL 1011
E+ L + + +Q E KS++++ + ++ + ++++ + +
Sbjct: 1553 AEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNH--IRIVESMQSTLDA- 1609
Query: 1012 WNELDSLKDAVEHQRKKN---NERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHG 1068
E+ S DA+ ++K NE + Q+ A E L+ G
Sbjct: 1610 --EIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNY-------------RNTQG 1654
Query: 1069 FEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSV 1128
K + + S+E L+ +L + LLQ E E+ ++ L +TE + ++
Sbjct: 1655 ILKDTQIHLDDALRSQE--DLKEQLAMVERRANLLQAEIEELRATLEQTE----RSRKIA 1708
Query: 1129 EQEENKWKVKVDESH-------KTIKQMQSSFTSSEQELERLRSENKDI-ENLRREREHL 1180
EQE +V H T K++++ + + E+E + E ++ E ++
Sbjct: 1709 EQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDA 1768
Query: 1181 EMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKI 1240
M E+ + E+ T + +K + +T+ L+ +E +++A L ++ ++ +++++
Sbjct: 1769 AMMAEELKKEQDT-SAHLERMKKNMEQTVKDLQLRLDEAEQLA--LKGGKKQIQKLEARV 1825
Query: 1241 VKAAGD 1246
+ G+
Sbjct: 1826 RELEGE 1831
Score = 144 bits (362), Expect = 7e-34
Identities = 222/1141 (19%), Positives = 492/1141 (43%), Gaps = 144/1141 (12%)
Query: 180 KVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDN 239
K++ L+ ++ ++ + +E Q+ K+ +K+++ E V L+ + L
Sbjct: 841 KIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVT--LLKEKNDLQLQVQ 898
Query: 240 ADSSPVVDKREVID-LLKPD-QVEGIQKSGTKKLKTETDKENAEV-----KFKDFLLSLK 292
A++ + D E D L+K Q+E K T++ + E ++ NAE+ K +D LK
Sbjct: 899 AEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDE-EEINAELTAKKRKLEDECSELK 957
Query: 293 TMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATK 352
+ +D L + + KEK +++ ++ L ++ D+ +A + ++ A +
Sbjct: 958 KDI--DDLELTLAKVEKEKH---------ATENKVKNLTEEMAGLDETIAKLTKEKKALQ 1006
Query: 353 DRCKQLTQEMMTEKERSNVVIT-------RMKDRIGTLEKEHNV------FQNKIHVSYQ 399
+ +Q ++ E+++ N + ++ D G+LE+E + + K+ +
Sbjct: 1007 EAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLK 1066
Query: 400 ETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLV 459
Q+ M + ++Q++ ++ + E +SN +++E +Q+ + +L++ L
Sbjct: 1067 LAQESIMDIENEKQQLDEKLKKKEFE-------ISNLQSKIEDEQALGI-QLQKKIKELQ 1118
Query: 460 NELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYI-------RKRTAEHE 512
+ E +++ E + AE+ + L +L+E R EE +KR AE +
Sbjct: 1119 ARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQ 1178
Query: 513 AAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQ 572
++DL+ + E +L K D++ +L +++ L +QK ++ ++M++
Sbjct: 1179 KMRRDLEEATLQHEATAATLRKKHADSVA---ELGEQIDNLQRVKQKLEKEKSEMKMEID 1235
Query: 573 DILEQNEAL---KAQIQQFHSQIAAQTSA-SVLAEELHKVIAEKDKQIKQTEDSLASERD 628
D+ E + K +++ + Q S EE ++I + Q + +
Sbjct: 1236 DLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSR 1295
Query: 629 RLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQ 688
+L KE + + ++++L+ E+ A + L QS D LL EQ
Sbjct: 1296 QLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCD---LLREQ 1352
Query: 689 LQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVE 748
+ E +K E + L+ N + K +T ++ E++E+ ++ ++L+ E
Sbjct: 1353 YEEEQESKAELQRALSKANTEVAQWRTKYETDAIQR-----TEELEEAKKKLAQRLQAAE 1407
Query: 749 ELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK----QNDQVSFASLVEELKKVIH 804
E +E + A+ E+ ++ E L +V+ A Q +F ++ E K+
Sbjct: 1408 EHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCE 1467
Query: 805 EKDGKIKSVEE---LLEAELLKVANKEKTVQD----LKQEIKALKEEIGNVQLEKAQQLS 857
E ++++ ++ L EL K+ N + D LK+E K L++EI ++ + A+
Sbjct: 1468 ETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEG-- 1525
Query: 858 ITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQ----- 912
++ EL+ + K E++ ++A LEE E L + + +Q E +K+ V
Sbjct: 1526 -GKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAE 1584
Query: 913 ------EVAQHNLKEASSASQFEELEIVLKEKENELKR-LEAMLKERESDLSSKTQLLQD 965
++ +++++ S + EI + LK+ +E L E E L+ ++ +
Sbjct: 1585 KDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAE 1644
Query: 966 VQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQ 1025
+ +++ LK + E+L + ++ E+ + L E++ L+ +E
Sbjct: 1645 AL---RNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQT 1701
Query: 1026 RKKNNERQQQV----EAVELEAKEVLKKLFPKVSVPSNLSY--GEW------LHGFEKKA 1073
+ +Q++ E V+L + + K + +++S GE E+KA
Sbjct: 1702 ERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKA 1761
Query: 1074 KECMAGTSG-SEEVKV-------LEHKLKEADEMHTLLQLECEKY--------KSVLAET 1117
K+ + + +EE+K LE K ++ LQL ++ K + +
Sbjct: 1762 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKL 1821
Query: 1118 EGILQKLQRSVEQEENK-----------------WKVKVDESHKTIKQMQSSFTSSEQEL 1160
E +++L+ VE E+ + + +E K I ++Q + ++
Sbjct: 1822 EARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKV 1881
Query: 1161 ERLRSENKDIE-----NLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTE 1215
+ + + ++ E NL + R+ L+ ELE+AE ++V +L+ + E TK+ +E
Sbjct: 1882 KSYKRQAEEAEEQSNTNLAKFRK-LQHELEEAEERADIAESQVNKLRVKSREVHTKVISE 1940
Query: 1216 Q 1216
+
Sbjct: 1941 E 1941
Score = 95.1 bits (235), Expect = 4e-19
Identities = 123/611 (20%), Positives = 276/611 (45%), Gaps = 69/611 (11%)
Query: 712 SEVQKLQTLVSE--QPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIR 769
+E +K + E Q KD + + E +E +EK+ T+ + +QV + E L
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAE 908
Query: 770 TENSSLTKEVQDLKAKQNDQVSFASLVEEL-------KKVIHEKDGKIKSVEELLEAELL 822
L K L+AK + A EE+ K+ + ++ ++K + LE L
Sbjct: 909 ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 968
Query: 823 KVANK----EKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNT 878
KV + E V++L +E+ L E I + EK ++ Q+ + L+ +E+++NT
Sbjct: 969 KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKK---ALQEAHQQTLDDLQAEEDKVNT 1025
Query: 879 M---KAVLEEKEKDLANTGKWLQDLQEENESLKAHVQ---EVAQHNLKEASSASQFEELE 932
+ K LE++ DL + + + L+ + E K ++ ++AQ ++ + + Q +L+
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQ--QLD 1083
Query: 933 IVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFP 992
LK+KE E+ L++ +++ ++ L +Q + K +++IE+L+++ + +S
Sbjct: 1084 EKLKKKEFEISNLQSKIEDEQA-------LGIQLQKKIKELQARIEELEEEIEAERASRA 1136
Query: 993 PHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFP 1052
E+ +S +EIS L+ A Q + N +R+ + + + + +E
Sbjct: 1137 KAEKQRSDLSRELEEIS---ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE------- 1186
Query: 1053 KVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKS 1112
+ L + KK + +A E++ L+ ++ ++ + +++E + S
Sbjct: 1187 -----ATLQHEATAATLRKKHADSVAEL--GEQIDNLQRVKQKLEKEKSEMKMEIDDLAS 1239
Query: 1113 ---VLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKD 1169
+++ +G L+K+ R++E + ++ K K +E + I + + + RL++E+ +
Sbjct: 1240 NVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTA-------QRGRLQTESGE 1292
Query: 1170 IENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKA 1229
E+E L +L + + + ++ ELK QL E E + +A L +
Sbjct: 1293 FSRQLDEKEALVSQLSRG---KQAFTQQIEELKRQLEE-------EIKAKNALAHALQSS 1342
Query: 1230 QQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKET-MSVSLNQTVTQLQQLLQAVNQQ 1288
+ +L++ + + ++ + TE ++ T Q +L++ + + Q+
Sbjct: 1343 RHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1402
Query: 1289 LTKEKEHYQVL 1299
L +EH + +
Sbjct: 1403 LQAAEEHVEAV 1413
Score = 79.7 bits (195), Expect = 2e-14
Identities = 111/520 (21%), Positives = 228/520 (43%), Gaps = 84/520 (16%)
Query: 821 LLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQ----QLSITSKVQELQNLLKGKEE-- 874
LLK A EK + +K+E + +K+E+ + ++ + +++ + +LQ ++ + E
Sbjct: 845 LLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904
Query: 875 --------QMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSAS 926
Q+ K LE K K++ + +++ E + K +++ K+
Sbjct: 905 ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD----- 959
Query: 927 QFEELEIVL----KEK---ENELKRL-----------EAMLKERESDLSSKTQLLQDVQD 968
++LE+ L KEK EN++K L + KE+++ + Q L D+Q
Sbjct: 960 -IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQA 1018
Query: 969 E----NKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEH 1024
E N L K++I +L+QQ S ++L + ++++ G LK A E
Sbjct: 1019 EEDKVNTLTKAKI-KLEQQVDDLEGSLEQEKKLRMDLERAKRKLEG------DLKLAQES 1071
Query: 1025 QRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSG-S 1083
NE+QQ E ++ + E+ L K+ L +KK KE A
Sbjct: 1072 IMDIENEKQQLDEKLKKKEFEI-SNLQSKIEDEQALGI-----QLQKKIKELQARIEELE 1125
Query: 1084 EEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQ-KLQRSVEQEENKWKVKVDES 1142
EE++ +A++ + L E E+ L E G +++ + ++E K++ D
Sbjct: 1126 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE 1185
Query: 1143 HKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVREL- 1201
T++ ++ T ++ + + + I+NL+R ++ LE E + +ME + V +
Sbjct: 1186 EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVS 1245
Query: 1202 KAQ---------LNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIEN 1252
KA+ L + L++L++++ E+Q++ DL + L+ E+
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQ---------------TES 1290
Query: 1253 SDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKE 1292
+ S + + EKE + L++ Q ++ + +QL +E
Sbjct: 1291 GEFSRQLD--EKEALVSQLSRGKQAFTQQIEELKRQLEEE 1328
Score = 35.4 bits (80), Expect = 0.36
Identities = 39/221 (17%), Positives = 93/221 (42%), Gaps = 11/221 (4%)
Query: 1085 EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVE---QEENKWKVKVDE 1141
++K L + EM T+ + E +K K LA++E ++L+ + +E+N +++V
Sbjct: 841 KIKPLLKSAETEKEMATMKE-EFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQA 899
Query: 1142 SHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMEL--EKAEMERSTYVTEVR 1199
+ + + + +L ++ K++ + E + EL +K ++E E
Sbjct: 900 EAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLE-----DECS 954
Query: 1200 ELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPET 1259
ELK +++ L + E+ + + + + I K + ++ +
Sbjct: 955 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1014
Query: 1260 ESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
+ +E +L + +L+Q + + L +EK+ LE
Sbjct: 1015 DLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLE 1055
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 158 bits (400), Expect = 3e-38
Identities = 223/1092 (20%), Positives = 476/1092 (43%), Gaps = 161/1092 (14%)
Query: 308 LKEKSGVIQDALKKSS--KGELTT-LIHQLQEKDKLLAAVKEDA---AATKDRCKQLTQ- 360
+KE+ +D L KS + EL ++ L+EK+ L V+ +A A ++RC+QL +
Sbjct: 855 MKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKN 914
Query: 361 ------------EMMTEKERSNVVIT----RMKDRIGTLEKEHNVFQNKIHVSYQETQQM 404
E E+E N +T +++D L+K+ + + + +E
Sbjct: 915 KIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 974
Query: 405 QMKFQQVREQM---EAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE 461
+ K + + E+M + IA L +E L++ T + L++++ ++N L + +L +
Sbjct: 975 ENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEED-KVNILTKAKTKLEQQ 1033
Query: 462 LTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSK 521
+ + G L+QE+ +L++ L+ A+R+ E ++ T + E +Q L K
Sbjct: 1034 VDDLEGSLEQEK-----------KLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEK 1082
Query: 522 FVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLM--------ESEQKRVNKEESLQMQVQD 573
KE E+ +L SK+ D + QL++++ +L E E +R ++ ++ + Q D
Sbjct: 1083 LEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKA-EKQRSD 1141
Query: 574 ILEQNEALKAQIQQFHSQIAAQTSAS--------VLAEELHKVIAEKDKQI----KQTED 621
+ + E + ++++ +AQ + L +L + + + + K+ D
Sbjct: 1142 LSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHAD 1201
Query: 622 SLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDK 681
S+A +++ + + + ++ LK E L + A + A LEKM +S+ + +
Sbjct: 1202 SMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSE 1261
Query: 682 IRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSE-----QPNKDVVEQMEKC 736
++ EE+ Q I++ + L + ++ + LVS+ Q + +E+++
Sbjct: 1262 LKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQ 1321
Query: 737 IQEKDEKLKTVEELLETG-----LIQVATKEEELNAIRTEN--SSLTKEVQDLKAK-QND 788
++E+ + + L++ L++ +EE+ + S EV + K + D
Sbjct: 1322 LEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETD 1381
Query: 789 QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGN- 847
+ +EE KK + + +++ EE +EA K A+ EKT Q L+ E++ L ++
Sbjct: 1382 AIQRTEELEEAKKKLAQ---RLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERS 1438
Query: 848 ----VQLEKAQQ------LSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWL 897
L+K Q+ K +E Q L+ +++ ++ L + + + L
Sbjct: 1439 NAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQL 1498
Query: 898 QDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLS 957
+ L+ EN++L+ QE++ + A Q ELE + K+ E E ++A L+E E+ L
Sbjct: 1499 ETLRRENKNLQ---QEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLE 1555
Query: 958 SKTQLLQDVQDENKLFKS-----------QIEQLKQQNYQQASSFP--------PHEELL 998
+ + +Q E KS +I+QLK+ + + + + L
Sbjct: 1556 HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDAL 1615
Query: 999 KVISEREKEISGLWNELD-SLKDAVEHQRKKNN------ERQQQVEAVELEAKEVLKKLF 1051
+V + E +++ + +L+ + + A E R N E Q ++ L +E LK+
Sbjct: 1616 RVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDA-LRGQEDLKEQL 1674
Query: 1052 PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEV-KVLEHKLKEADEMHTLLQLECEKY 1110
V +NL + + +E A +E K+ E +L +A E LL +
Sbjct: 1675 AIVERRANL--------LQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQ---- 1722
Query: 1111 KSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDI 1170
+ L T+ +KL+ V Q +++ + + ES ++ + + T + E L+ E
Sbjct: 1723 NTSLINTK---KKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTS 1779
Query: 1171 ENLRREREHLEMEL--------EKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKV 1222
+L R +++LE + E ++ ++++L+A++ E ++ EQ +
Sbjct: 1780 AHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEA 1839
Query: 1223 AGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLL 1282
L K ++ ++ +++ +TE K + L V +LQ +
Sbjct: 1840 VKGLRKHERRVK-------------------ELTYQTEEDRKNVL--RLQDLVDKLQAKV 1878
Query: 1283 QAVNQQLTKEKE 1294
++ +Q + +E
Sbjct: 1879 KSYKRQAEEAEE 1890
Score = 153 bits (387), Expect = 9e-37
Identities = 229/1153 (19%), Positives = 496/1153 (43%), Gaps = 170/1153 (14%)
Query: 180 KVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDN 239
K++ L+ ++ ++ + +E Q++ K+ +K+++ E V L+ + L
Sbjct: 838 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVT--LLKEKNDLQLQVQ 895
Query: 240 ADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKE-NAEV-----KFKDFLLSLKT 293
+++ + D E + L ++++ K + E ++E NAE+ K +D LK
Sbjct: 896 SEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKK 955
Query: 294 MMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKD 353
+ +D L + + KEK +++ ++ L ++ D+ +A + ++ A ++
Sbjct: 956 DI--DDLELTLAKVEKEKH---------ATENKVKNLTEEMAGLDETIAKLSKEKKALQE 1004
Query: 354 RCKQLTQEMMTEKERSNVVI---TRMKDRI----GTLEKEHNV------FQNKIHVSYQE 400
+Q ++ E+++ N++ T+++ ++ G+LE+E + + K+ +
Sbjct: 1005 THQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKL 1064
Query: 401 TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVN 460
Q+ M + ++Q++ ++ + E +SN +++E +Q+ E+ +L++ L
Sbjct: 1065 AQESTMDMENDKQQLDEKLEKKEFE-------ISNLISKIEDEQAVEI-QLQKKIKELQA 1116
Query: 461 ELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYI-------RKRTAEHEA 513
+ E +++ E + AE+ + L +L+E R EE +KR AE +
Sbjct: 1117 RIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQK 1176
Query: 514 AQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQD 573
++DL+ + E V +L K D++ +L +++ L +QK ++ L+M+ D
Sbjct: 1177 LRRDLEEATLQHEAMVAALRKKHADSMA---ELGEQIDNLQRVKQKLEKEKSELKMETDD 1233
Query: 574 ILEQNEAL---KAQIQQFHSQIAAQTSASVLAEE---------------LHKVIAEKDKQ 615
+ EA+ K +++ + Q S EE L E +Q
Sbjct: 1234 LSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQ 1293
Query: 616 IKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSV 675
+ + +D+L S+ R SK+ + I+ + L+ E + ALA+ ++ H+ +
Sbjct: 1294 LDE-KDALVSQLSR--SKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCD------ 1344
Query: 676 YVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEK 735
LL EQ + E K E + L+ N + K +T ++ E++E+
Sbjct: 1345 --------LLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQR-----TEELEE 1391
Query: 736 CIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK----QNDQVS 791
++ ++L+ EE +E + A+ E+ ++ E L +V+ A Q +
Sbjct: 1392 AKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRN 1451
Query: 792 FASLVEELKKVIHEKDGKIKSVEE---LLEAELLKVANKEKTVQD----LKQEIKALKEE 844
F ++ E K+ E ++++ ++ L EL KV N + D L++E K L++E
Sbjct: 1452 FDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQE 1511
Query: 845 IGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEEN 904
I ++ + A+ ++ EL+ + K E++ ++A LEE E L + + +Q E
Sbjct: 1512 ISDLTEQIAEG---GKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLEL 1568
Query: 905 ESLKAHV--------QEVAQHNLKEASSASQFEE-LEIVLKEKENEL---KRLEAMLKER 952
+K+ V +E+ Q + L+ ++ + + L K++E L E
Sbjct: 1569 NQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEM 1628
Query: 953 ESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEEL---LKVISER----E 1005
E L+ +L + + +++ LK+ + E+L L ++ R +
Sbjct: 1629 EIQLNHANRL---AAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQ 1685
Query: 1006 KEISGLWNELDSLKDA---VEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVS-VPSNLS 1061
EI LW L+ + + E + +ER Q + KKL VS + S +
Sbjct: 1686 AEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVE 1745
Query: 1062 YG-EWLHGFEKKAKECMAGTSGSEE----------------------VKVLEHKLKEADE 1098
+ E+KAK+ + + E VK L+H+L EA++
Sbjct: 1746 EVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ 1805
Query: 1099 MHTLL-QLECEKYKSVLAETEGILQKLQ----------RSVEQEENKWKVKVDESHKTIK 1147
+ + + +K ++ + E EG ++ Q R E+ + + +E K +
Sbjct: 1806 LALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVL 1865
Query: 1148 QMQSSFTSSEQELERLRSENKDIE-----NLRREREHLEMELEKAEMERSTYVTEVRELK 1202
++Q + +++ + + ++ E NL + R+ L+ ELE+AE ++V +L+
Sbjct: 1866 RLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRK-LQHELEEAEERADIAESQVNKLR 1924
Query: 1203 AQLNETLTKLRTE 1215
+ E TK+ E
Sbjct: 1925 VKSREVHTKISAE 1937
Score = 92.4 bits (228), Expect = 2e-18
Identities = 121/615 (19%), Positives = 274/615 (44%), Gaps = 77/615 (12%)
Query: 712 SEVQKLQTLVSE--QPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIR 769
+E +K + E Q KD + + E +E +EK+ T+ + +QV ++ + L
Sbjct: 846 AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAE 905
Query: 770 TENSSLTKEVQDLKAKQNDQVSFASLVEEL-------KKVIHEKDGKIKSVEELLEAELL 822
L K L+AK + A EE+ K+ + ++ ++K + LE L
Sbjct: 906 ERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 965
Query: 823 KVANK----EKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNT 878
KV + E V++L +E+ L E I + EK ++ Q+ + L+ +E+++N
Sbjct: 966 KVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKK---ALQETHQQTLDDLQAEEDKVNI 1022
Query: 879 M---KAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVL 935
+ K LE++ DL + + + L+ + E K + + +LK A ++
Sbjct: 1023 LTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKL----EGDLKLAQESTM-------- 1070
Query: 936 KEKENELKRLEAMLKERESDLSSKTQLLQD-------VQDENKLFKSQIEQLKQQNYQQA 988
+ EN+ ++L+ L+++E ++S+ ++D +Q + K +++IE+L ++ +
Sbjct: 1071 -DMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAER 1129
Query: 989 SSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLK 1048
+S E+ +S +EIS L+ A Q + N +R+ + + + + +E
Sbjct: 1130 ASRAKAEKQRSDLSRELEEIS---ERLEEAGGATSAQVELNKKREAEFQKLRRDLEE--- 1183
Query: 1049 KLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECE 1108
+ L + + KK + MA E++ L+ ++ ++ + L++E +
Sbjct: 1184 ---------ATLQHEAMVAALRKKHADSMAEL--GEQIDNLQRVKQKLEKEKSELKMETD 1232
Query: 1109 KYKS---VLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRS 1165
S +++ +G L+K+ RS+E + ++ K K +E + I + + + RL++
Sbjct: 1233 DLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTA-------QRARLQT 1285
Query: 1166 ENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGD 1225
E + E++ L +L ++ + ++ ELK QL E E + +A
Sbjct: 1286 EAGEYSRQLDEKDALVSQLSRS---KQASTQQIEELKHQLEE-------ETKAKNALAHA 1335
Query: 1226 LHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKET-MSVSLNQTVTQLQQLLQA 1284
L ++ +L++ + + ++ + +E ++ T Q +L++ +
Sbjct: 1336 LQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1395
Query: 1285 VNQQLTKEKEHYQVL 1299
+ Q+L + +EH + +
Sbjct: 1396 LAQRLQEAEEHVEAV 1410
Score = 77.8 bits (190), Expect = 6e-14
Identities = 107/518 (20%), Positives = 220/518 (42%), Gaps = 81/518 (15%)
Query: 821 LLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQ---------------QLSITSKVQEL 865
LLK A EK + +K+E + K+E+ + ++ + QL + S+ L
Sbjct: 842 LLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSL 901
Query: 866 QNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSA 925
+ + + EQ+ K LE K K++ + +++ E + K +++ K+
Sbjct: 902 AD-AEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKD---- 956
Query: 926 SQFEELEIVL----KEK---ENELKRL-----------EAMLKERESDLSSKTQLLQDVQ 967
++LE+ L KEK EN++K L + KE+++ + Q L D+Q
Sbjct: 957 --IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQ 1014
Query: 968 DE----NKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVE 1023
E N L K++ +L+QQ S ++L + ++++ G LK A E
Sbjct: 1015 AEEDKVNILTKAK-TKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEG------DLKLAQE 1067
Query: 1024 HQRKKNNERQQ---QVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGT 1080
N++QQ ++E E E ++ K+ + +V L +KK KE A
Sbjct: 1068 STMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQL---------QKKIKELQARI 1118
Query: 1081 SG-SEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQ-KLQRSVEQEENKWKVK 1138
EE++ +A++ + L E E+ L E G +++ + ++E K++
Sbjct: 1119 EELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLR 1178
Query: 1139 VDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMER------- 1191
D T++ ++ + + + I+NL+R ++ LE E + +ME
Sbjct: 1179 RDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNA 1238
Query: 1192 ---STYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTT 1248
S + ++ L + +++L+T++ E+Q++ DL + L+ +A +
Sbjct: 1239 EAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQ------TEAGEYSR 1292
Query: 1249 VIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVN 1286
++ D S K+ + + + QL++ +A N
Sbjct: 1293 QLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKN 1330
Score = 73.9 bits (180), Expect = 9e-13
Identities = 113/568 (19%), Positives = 242/568 (42%), Gaps = 74/568 (13%)
Query: 778 EVQDLKAKQNDQVSFASLVEELKKV---IHEKDGKIKSVEELLEAELLKVAN-------- 826
+++ L + A++ EE +K + + + K K +EE + LLK N
Sbjct: 838 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKM-VTLLKEKNDLQLQVQS 896
Query: 827 --------KEKTVQDLKQEIK---ALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQ 875
+E+ Q +K +I+ +KE + E+ +T+K ++L++ ++
Sbjct: 897 EADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKD 956
Query: 876 MNTMKAVLEEKEKDLANTGKWLQDLQEENESL----------KAHVQEVAQHNLKEASSA 925
++ ++ L + EK+ T +++L EE L K +QE Q L +
Sbjct: 957 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQ-- 1014
Query: 926 SQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNY 985
++ +++ I+ K K +LE + + E L + +L D++ + + ++ ++
Sbjct: 1015 AEEDKVNILTKAK----TKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTM 1070
Query: 986 QQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQ-RKKNNERQQQVEAV--ELE 1042
+ ++L + + ++E EIS L ++++ + AVE Q +KK E Q ++E + E+E
Sbjct: 1071 DMEND---KQQLDEKLEKKEFEISNLISKIED-EQAVEIQLQKKIKELQARIEELGEEIE 1126
Query: 1043 AKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEV--------KVLEHKLK 1094
A+ + K S+LS L ++ +E TS E+ + L L+
Sbjct: 1127 AERASRAKAEKQR--SDLS--RELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLE 1182
Query: 1095 EADEMHTLLQLECEK----YKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQ 1150
EA H + K + L E LQ++++ +E+E+++ K++ D+ +
Sbjct: 1183 EATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDD----LSSNA 1238
Query: 1151 SSFTSSEQELERL-RSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETL 1209
+ + ++ LE++ RS + L+ + E + + +R+ TE E QL+E
Sbjct: 1239 EAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKD 1298
Query: 1210 TKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSV 1269
+ +Q + + + LE ++K A D E E+E
Sbjct: 1299 ALVSQLSRSKQASTQQIEELKHQLE-EETKAKNALAHALQSSRHDCDLLREQYEEE---- 1353
Query: 1270 SLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1297
+ +LQ+ L N ++ + + Y+
Sbjct: 1354 --QEGKAELQRALSKANSEVAQWRTKYE 1379
Score = 69.7 bits (169), Expect = 2e-11
Identities = 144/740 (19%), Positives = 289/740 (39%), Gaps = 88/740 (11%)
Query: 54 KKKAEKKKNKKKEIQNGNLHESDSESVPR-DFKLSDALAVEDDQVAPVPLNVVETSSSVR 112
K+K EK+K++ K ++ +L S++E++ + L +DQV+ + E +
Sbjct: 1217 KQKLEKEKSELK-METDDL-SSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLIN 1274
Query: 113 E-------------RKKKEKKQKPVLEEQVIKESDAS--KIPGKKVEPVPVTKQPTPPSE 157
+ ++ +K L Q+ + AS +I K + TK +
Sbjct: 1275 DLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAH 1334
Query: 158 AAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQ--------ETKQESGSGKK 209
A S + + ++Q+ K E SK + + + +E KK
Sbjct: 1335 ALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK 1394
Query: 210 KASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTK 269
K + + Q+ E H + + + + EV DL+ + +
Sbjct: 1395 KLAQRLQEAEE--------HVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALD 1446
Query: 270 KLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDAL---------K 320
K + DK +E K K + ++ +L K K+ V +++L
Sbjct: 1447 KKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKN-VYEESLDQLETLRREN 1505
Query: 321 KSSKGELTTLIHQLQEKDKL---LAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMK 377
K+ + E++ L Q+ E K L +K+ K + +E E I R++
Sbjct: 1506 KNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQ 1565
Query: 378 DRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEI-AHLKQENGILR--DAVS 434
+ ++ E KI +E Q++ +V E M++ + A ++ N LR +
Sbjct: 1566 LELNQVKSE---VDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKME 1622
Query: 435 NTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAE 494
N++E +LN + A + G L++ ++ +A + LK QL E
Sbjct: 1623 GDLNEME----IQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVE 1678
Query: 495 RRWEEVQSYIRKRTA---EHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLM 551
RR +Q+ I + A + E +++ + + + VQ LH++ T + +K++LE +
Sbjct: 1679 RRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVS 1738
Query: 552 QLM----ESEQKRVNKEESLQMQVQDILEQNEALK------AQIQQFHSQIAAQTSASVL 601
QL E Q+ N EE + + D E LK A +++ + QT +
Sbjct: 1739 QLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLE-QTVKDLQ 1797
Query: 602 -----AEEL-----HKVIAEKDKQIKQTEDSLASERDR-------LTSKEEELKDIQNMN 644
AE+L K I + + ++++ E + +E+ R L E +K++
Sbjct: 1798 HRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQT 1857
Query: 645 FLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILN 704
+ V +LQ L ++ A ++ + + + +LQHE+ E I
Sbjct: 1858 EEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAE 1917
Query: 705 DQNKALKSEVQKLQTLVSEQ 724
Q L+ + +++ T +S +
Sbjct: 1918 SQVNKLRVKSREVHTKISAE 1937
Score = 38.9 bits (89), Expect = 0.032
Identities = 41/221 (18%), Positives = 94/221 (42%), Gaps = 11/221 (4%)
Query: 1085 EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVE---QEENKWKVKVDE 1141
++K L + EM T+ + E +K K LA++E ++L+ + +E+N +++V
Sbjct: 838 KIKPLLKSAETEKEMATMKE-EFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQS 896
Query: 1142 SHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMEL--EKAEMERSTYVTEVR 1199
++ + + +L ++ K++ E E + EL +K ++E E
Sbjct: 897 EADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLE-----DECS 951
Query: 1200 ELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPET 1259
ELK +++ L + E+ + + + + I K + + ++ +
Sbjct: 952 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLD 1011
Query: 1260 ESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
+ +E L + T+L+Q + + L +EK+ LE
Sbjct: 1012 DLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLE 1052
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 157 bits (398), Expect = 5e-38
Identities = 288/1342 (21%), Positives = 549/1342 (40%), Gaps = 182/1342 (13%)
Query: 36 EVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNL-----HESDSESVPRDFK---LS 87
E L KQ + +K + KK ++KN EI G L H S + P K L
Sbjct: 354 EWLEKQAQLEKELSAALQDKKCLEEKN---EILQGKLSQLEEHLSQLQDNPPQEKGEVLG 410
Query: 88 DALAVED--DQVAPVPLNVVETSSSVR----ERKKKEKKQKPVLEEQVIKESDASKIPGK 141
D L +E + A + N + + V ER ++E K +L E+ E + ++
Sbjct: 411 DVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAK---LLAERGHFEEEKQQLSSL 467
Query: 142 KVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLH---Q 198
+T + S + +K++ Q +G+ T V S E L+ Q
Sbjct: 468 ------ITDLQSSISNLSQAKEELEQASQAHGAR------LTAQVASLTSELTTLNATIQ 515
Query: 199 ETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPD 258
+ QE K++A K+ + + A+ + SS + K + + +
Sbjct: 516 QQDQELAGLKQQAKEKQAQLAQTLQQQE--QASQGLRHQVEQLSSSLKQKEQQLKEVAEK 573
Query: 259 QVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDA 318
Q E ++ ++L T ++ A ++ +D +LK + E E +++L+++ V +A
Sbjct: 574 Q-EATRQDHAQQLATAAEEREASLRERD--AALKQLEALEKEKAAKLEILQQQLQVANEA 630
Query: 319 LKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKD 378
+ T + Q Q + L+ E+ A + +Q E +
Sbjct: 631 -----RDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQ------------- 672
Query: 379 RIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTN 438
+ LE + Q K E +++ + Q++EQ++A LK G L + +
Sbjct: 673 -VAELELQLRSEQQKA----TEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAAD 727
Query: 439 QLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWE 498
LE +Q +++L+ + LV + + +L++E +K E QL EA +
Sbjct: 728 ALEEQQRC-ISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLG----EAHQAET 782
Query: 499 EVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQ 558
EV +R+ AE AAQ +S+ EV + + D+ Q E+ M EQ
Sbjct: 783 EV---LRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDS-----QQEEAQYGAMFQEQ 834
Query: 559 KRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQ 618
KEE + + Q++ E E + A I+ HS++ + LAE LH +A +Q+++
Sbjct: 835 LMTLKEECEKAR-QELQEAKEKV-AGIES-HSELQISRQQNELAE-LHANLARALQQVQE 890
Query: 619 TEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVK 678
E D L++ +E++ L+ V+K +Q A+ EL K +
Sbjct: 891 KEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKA---GEQQETASRELVK--EPARAG 945
Query: 679 DDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQ 738
D + LEEQ + + + + + + + +E+++L+ + E + +Q E+ Q
Sbjct: 946 DRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQ---QQEERGQQ 1002
Query: 739 EKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEE 798
E++ T E + +L + + L +Q+ A +V FA+L E
Sbjct: 1003 EREVARLTQER---------GRAQADLALEKAARAELEMRLQN--ALNEQRVEFATLQEA 1051
Query: 799 LKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSI 858
L + EK+GK + + +L E ++ K +++L+Q +K LKE++ + E A
Sbjct: 1052 LAHALTEKEGKDQELAKLRGLEAAQI----KELEELRQTVKQLKEQLAKKEKEHASGSGA 1107
Query: 859 TSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHN 918
S+ K E + + LE++ Q QE+ +SL+ ++
Sbjct: 1108 QSEAAGRTEPTGPKLEALRAEVSKLEQQ----------CQKQQEQADSLERSLEA---ER 1154
Query: 919 LKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIE 978
A S E L+ L+EK EL ++ L + +L++ +QD +K+Q+
Sbjct: 1155 ASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVA 1214
Query: 979 QLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQ--QV 1036
+ +Q+ ++ S EE + +++ + E G EL L A + +K ER + Q
Sbjct: 1215 RGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQA 1274
Query: 1037 EAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSG-----SEEVKVLEH 1091
E A+ + + V S E + ++ + + +E+K +
Sbjct: 1275 ETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQE 1334
Query: 1092 KLKEADEMHTLLQLECEKYKSVLAE---TEGILQKLQ---------RSVEQEENK----- 1134
K + ++ + LQLE +++++E + + Q+LQ E E++K
Sbjct: 1335 KFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGG 1394
Query: 1135 -----------------WKVKVDESHKTIKQMQSSFTSSEQELERLR-------SENKDI 1170
+ KV E +T +Q+++ S ++L L+ EN+ +
Sbjct: 1395 LRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGL 1454
Query: 1171 -ENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKA 1229
E R+ LE+EL++A R YV E+ ++A + T+L Q E Q A +L
Sbjct: 1455 GERANLGRQFLEVELDQA---REKYVQELAAVRA---DAETRLAEVQREAQSTARELEVM 1508
Query: 1230 QQSLELIQSKIVKAAGD--------TTVIENSDVSPETESSEKETMSVSL---NQTVTQL 1278
E + K+++ T +E +V ++ + E +S L +Q
Sbjct: 1509 TAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQ 1568
Query: 1279 QQLLQAVNQQLTKEKEHYQVLE 1300
QQ L+AV Q + ++ Q L+
Sbjct: 1569 QQKLKAVQAQGGESQQEAQRLQ 1590
Score = 145 bits (365), Expect = 3e-34
Identities = 232/1044 (22%), Positives = 426/1044 (40%), Gaps = 177/1044 (16%)
Query: 316 QDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITR 375
Q A ++S++ EL +L E KLL A + R +L ++ EK+ ++ + +
Sbjct: 222 QLADERSNRDELEL---ELAENRKLLTEKDAQIAMMQQRIDRLA--LLNEKQAASPLEPK 276
Query: 376 MKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSN 435
+ L ++ ++H + ++ Q ++ + + QM+ +I L +ENG L +
Sbjct: 277 ---ELEELRDKNESLTMRLHETLKQCQDLKTE----KSQMDRKINQLSEENGDLSFKLRE 329
Query: 436 TTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAER 495
+ L+ Q A +NELTE+ K QE
Sbjct: 330 FASHLQQLQDA------------LNELTEEHSKATQE----------------------- 354
Query: 496 RWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLME 555
W E Q+ + K E AA QD K + ++NE+ L KL+ QLE+ L QL +
Sbjct: 355 -WLEKQAQLEK---ELSAALQD--KKCLEEKNEI--LQGKLS-------QLEEHLSQLQD 399
Query: 556 SEQKR-------VNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKV 608
+ + V + E+L+ + + N L+A+++ ++ Q A +LAE H
Sbjct: 400 NPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETE-RGQQEAKLLAERGH-- 456
Query: 609 IAEKDKQIKQTEDSLASERDRLTSKEEELK-------------------DIQNMNFLLKA 649
E+ +Q+ L S L+ +EEL+ ++ +N ++
Sbjct: 457 FEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQ 516
Query: 650 EVQKLQALANE----QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILND 705
+ Q+L L + QA A L++ +Q+ +R EQL + K ++ K + +
Sbjct: 517 QDQELAGLKQQAKEKQAQLAQTLQQQEQA----SQGLRHQVEQLSSSLKQKEQQLKEVAE 572
Query: 706 QNKALKSE-VQKLQTLVSE-----QPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVA 759
+ +A + + Q+L T E + ++Q+E +EK KL+ +++ L+
Sbjct: 573 KQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARD 632
Query: 760 TKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEA 819
+ + + + E + L+++V++L+A VE ++ HE ++ +E L +
Sbjct: 633 SAQTSVTQAQREKAELSRKVEELQA----------CVETARQEQHEAQAQVAELELQLRS 682
Query: 820 ELLKVANKEKTVQD---LKQEIKALKEEI----GNVQLEKAQQLSITSKVQELQNLLKGK 872
E K KE+ Q+ L+++++ALKE + G+++ EK + + Q + LK +
Sbjct: 683 EQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAE 742
Query: 873 E----EQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQF 928
EQ + LEE+ LQ L E +++ EV + L EA +A
Sbjct: 743 TRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQA----ETEVLRRELAEAMAAQHT 798
Query: 929 EELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQA 988
E E E +K + A + E + Q Q++ K + E+ +Q+ Q+A
Sbjct: 799 AE-----SECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQE-LQEA 852
Query: 989 SSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEV-- 1046
E++ + S E +IS NEL L + QQV+ E+ A+++
Sbjct: 853 K-----EKVAGIESHSELQISRQQNELAELHANLA-------RALQQVQEKEVRAQKLAD 900
Query: 1047 -LKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKE----ADEMHT 1101
L L K++ S E E + +G ++ +KE D
Sbjct: 901 DLSTLQEKMAATSK----------EVARLETLVRKAGEQQETASRELVKEPARAGDRQPE 950
Query: 1102 LLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELE 1161
L+ E+ T+ LQ ++R EQ N+ + ++ Q Q E+E+
Sbjct: 951 WLE---EQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVA 1007
Query: 1162 RLRSE----NKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQN 1217
RL E D+ + R LEM L+ A E+ E L+ L LT+ +
Sbjct: 1008 RLTQERGRAQADLALEKAARAELEMRLQNALNEQR---VEFATLQEALAHALTEKEGKDQ 1064
Query: 1218 ERQKVAGDLHKAQ-QSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVT 1276
E K+ G L AQ + LE ++ + + E S SE + +
Sbjct: 1065 ELAKLRG-LEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLE 1123
Query: 1277 QLQQLLQAVNQQLTKEKEHYQVLE 1300
L+ + + QQ K++E LE
Sbjct: 1124 ALRAEVSKLEQQCQKQQEQADSLE 1147
Score = 132 bits (331), Expect = 3e-30
Identities = 251/1265 (19%), Positives = 527/1265 (41%), Gaps = 141/1265 (11%)
Query: 86 LSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEP 145
L+ + +D ++A + E + + + +++++ L QV + S + K ++++
Sbjct: 510 LNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKE 569
Query: 146 VP----VTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKR--QEALPLHQE 199
V T+Q A A++++ + ++ + Q + +E Q+ L + E
Sbjct: 570 VAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANE 629
Query: 200 TKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQ 259
+ + + +A +K + V+E + A + ++ V + E+ Q
Sbjct: 630 ARDSAQTSVTQAQREKAELSRK-VEE--LQACVETARQEQHEAQAQVAELEL-------Q 679
Query: 260 VEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFS-EDEALCVVDLLKEKSGVIQDA 318
+ Q+ T+K + +K+ + + + SLK S E+E D L+E+ I +
Sbjct: 680 LRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISEL 739
Query: 319 LKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQL-------TQEMMTEKERSNV 371
K E +L+ Q + + K L + + R +QL T+ + E +
Sbjct: 740 -----KAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMA 794
Query: 372 VITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRD 431
+ L KE ++ + S QE Q FQ+ ++ E +QE ++
Sbjct: 795 AQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKE 854
Query: 432 AVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQ 491
V+ + E + S + N+L + +A L L + +Q++EV+ + + L+ ++
Sbjct: 855 KVAGIESHSELQISRQQNELAELHANLARALQQ----VQEKEVRAQKLADDLSTLQEKMA 910
Query: 492 EAERRWEEVQSYIRKRTAEHEAAQQDLQSKFV-AKENEVQSLHSKLTDTLVSKQQLEQRL 550
+ +++ +RK + E A ++L + A + + + L + S Q
Sbjct: 911 ATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAA---- 966
Query: 551 MQLMESEQKRVNKE-ESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVI 609
+Q ME E +++ E E L+ + + Q + + Q ++ +++ + + L K
Sbjct: 967 LQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEK-- 1024
Query: 610 AEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELE 669
A + + + +++L +R + +E L E+ KL+ L +AA ELE
Sbjct: 1025 AARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGL---EAAQIKELE 1081
Query: 670 KMQQSVYVKDDKIRLLEEQ------LQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSE 723
+++Q+V +++ E++ Q E + + E + +AL++EV KL+ +
Sbjct: 1082 ELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEP---TGPKLEALRAEVSKLEQQCQK 1138
Query: 724 QPNKDVVEQMEKCIQ-------EKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLT 776
Q ++ + +E+ ++ E+D L+T++ LE ++ + L + + E ++
Sbjct: 1139 Q--QEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFR 1196
Query: 777 KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQ 836
+VQD +K D+ + + V ++ K+ I S+EE + +V KE ++LK+
Sbjct: 1197 TKVQD-HSKAEDE--WKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKR 1253
Query: 837 EIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKW 896
+ A + EK+Q+L EE++ ++A E + A +
Sbjct: 1254 LVMA--------ESEKSQKL----------------EERLRLLQA---ETASNSARAAER 1286
Query: 897 LQDLQEENESLK--AHVQEVAQHNLKE--ASSASQFEELEIVLK-------EKENELKRL 945
L+EE +SL+ A Q VA NL++ S A + EEL LK +KE L L
Sbjct: 1287 SSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTL 1346
Query: 946 EAMLKERE---SDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVIS 1002
+ + S+L L Q +Q E + + + +Q+ Q A ELL+
Sbjct: 1347 QLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGL--RAELLRA-- 1402
Query: 1003 EREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSY 1062
++E+ EL L+ V Q + + + + +A E +LKK ++ N
Sbjct: 1403 --QRELG----ELIPLRQKVAEQERTAQQLRAE-KASYAEQLSMLKKAHGLLA-EENRGL 1454
Query: 1063 GEW-----------LHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK 1111
GE L +K + +A E ++ E + +EA L++ KY+
Sbjct: 1455 GERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQ-REAQSTARELEVMTAKYE 1513
Query: 1112 S----VLAETEGIL---QKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLR 1164
VL E + QKL VEQ E + + + + K++ S +S+ + ++L+
Sbjct: 1514 GAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLK 1573
Query: 1165 SENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAG 1224
+ ++E + L+ +L + + + S K Q+ + T ++ + Q
Sbjct: 1574 AVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQ---- 1629
Query: 1225 DLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQA 1284
+L + +SLE +Q + + + + + ++ E E L V L+ +
Sbjct: 1630 ELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAH 1689
Query: 1285 VNQQL 1289
+QQL
Sbjct: 1690 ADQQL 1694
Score = 127 bits (319), Expect = 7e-29
Identities = 234/1094 (21%), Positives = 457/1094 (41%), Gaps = 131/1094 (11%)
Query: 50 TKTDKKKAEKKKNKKK-----EIQNGNLHESDSESVPRDFKL--SDALAVEDDQVAPVPL 102
T+ ++KAE + ++ E HE+ ++ + +L A E ++VA
Sbjct: 639 TQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKD 698
Query: 103 NVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASK 162
+ E +++E K K LEE+ + +DA + + + + + K
Sbjct: 699 QLQEQLQALKESLKVTKGS---LEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERK 755
Query: 163 KKPGQKKSKNGSD------DQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQ 216
+ ++ + G + + + ET ++ + EA+ + E K+ ++ ++
Sbjct: 756 ELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRE 815
Query: 217 KTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETD 276
+ E+ +E A LM + R+ + K ++V GI+ ++ + +
Sbjct: 816 RYEDSQQEEAQYGAMFQEQLMTLKEECEKA--RQELQEAK-EKVAGIESHSELQISRQQN 872
Query: 277 KENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSK--GELTTLIHQL 334
E AE+ + +L+ + E A + D L +Q+ + +SK L TL+ +
Sbjct: 873 -ELAELH-ANLARALQQVQEKEVRAQKLADDLS----TLQEKMAATSKEVARLETLVRKA 926
Query: 335 QEKDKLLAA--VKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQN 392
E+ + + VKE A A DR + +E + S + + +E+E N
Sbjct: 927 GEQQETASRELVKEPARAG-DRQPEWLEEQQGRQFCST------QAALQAMEREAEQMGN 979
Query: 393 KIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVS---NTTNQLESKQSAELN 449
++ + Q + Q+ R Q E E+A L QE G + ++ +LE + LN
Sbjct: 980 ELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALN 1039
Query: 450 KLRQDYARL----VNELTEKTGKLQQ-------EEVQKKNAE---QAATQLKVQLQEAER 495
+ R ++A L + LTEK GK Q+ E Q K E Q QLK QL + E+
Sbjct: 1040 EQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEK 1099
Query: 496 RWEE---VQSYIRKRTA----------------EHEAAQQDLQSKFVAKENEVQSLHSKL 536
QS RT E + +Q Q+ + + E +
Sbjct: 1100 EHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAE 1159
Query: 537 TDTLVS--KQQLEQRLMQLMESEQKRVNKEESL---QMQVQDILEQNEALKAQIQQFHSQ 591
D+ + + QLE++ +L S+ + + L + +VQD + + KAQ+ + +
Sbjct: 1160 RDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQE 1219
Query: 592 IAAQTSA-SVLAEE---LHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLL 647
+ S S L EE L++ + EK+ + K+ + + +E ++ EE L+ LL
Sbjct: 1220 AERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLR-------LL 1272
Query: 648 KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQN 707
+AE A A E+++A L + QS+ + +K R+ E L+ E++++ E + L +
Sbjct: 1273 QAETASNSARAAERSSA---LREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQEL 1329
Query: 708 KA--------------LKSEVQKLQTLVSEQ-PNKDVVEQM-------EKCIQEKDEKLK 745
KA L+ E Q LVSE P K + +Q+ EK +E+ E+ K
Sbjct: 1330 KAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSK 1389
Query: 746 TVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHE 805
L L++ + EL +R + + + Q L+A++ S++++ ++ E
Sbjct: 1390 QAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAE 1449
Query: 806 KDGKIKSVEEL----LEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSK 861
++ + L LE EL + +EK VQ+L + + VQ E S +
Sbjct: 1450 ENRGLGERANLGRQFLEVELDQA--REKYVQELAAVRADAETRLAEVQREAQ---STARE 1504
Query: 862 VQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKE 921
++ + +G + ++ + +E+ + L + L+ Q E V+E+++ L +
Sbjct: 1505 LEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTK---QVEELSK-KLAD 1560
Query: 922 ASSASQFEELEIVLK-----EKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQ 976
+ AS+ ++ ++ E + E +RL+A L E ++ LS K Q + + + + K+
Sbjct: 1561 SDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTH 1620
Query: 977 IEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQV 1036
+ KQQN + E+L K E E L +EL + + QV
Sbjct: 1621 YDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQV 1680
Query: 1037 EAVELEAKEVLKKL 1050
++E + ++L
Sbjct: 1681 RSLEAQVAHADQQL 1694
Score = 106 bits (264), Expect = 2e-22
Identities = 158/735 (21%), Positives = 318/735 (43%), Gaps = 78/735 (10%)
Query: 304 VVDLLKEKSGVIQD-ALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAAT-------KD-- 353
V L +E+ D AL+K+++ EL + + ++ A ++A A KD
Sbjct: 1006 VARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQE 1065
Query: 354 --RCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQV 411
+ + L + E E + ++K+++ EKEH + T+ K + +
Sbjct: 1066 LAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEAL 1125
Query: 412 REQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQ 471
R AE++ L+Q+ ++ + LE+++++ + L +L EK +L
Sbjct: 1126 R----AEVSKLEQQCQKQQEQADSLERSLEAERASRAER-DSALETLQGQLEEKAQELGH 1180
Query: 472 EEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQS 531
+ +A++ + ++Q+ + +E ++ + + E E + S E EV
Sbjct: 1181 SQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSL----EEEVSI 1236
Query: 532 LHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQD----ILEQNEALKAQIQQ 587
L+ ++ + ++L++ +M E QK + LQ + E++ AL+ ++Q
Sbjct: 1237 LNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQS 1296
Query: 588 FHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLL 647
+ Q AS E L + + + ++ ++ L + +++ KE+ L +Q +
Sbjct: 1297 LREEAEKQRVAS---ENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTST 1353
Query: 648 KAEVQKL-------QALANEQAAAA----HELEKMQQSVYVKDDKIRLLEEQLQHEIS-- 694
+A V +L Q L EQAAA ELE+ +Q+ ++ + +L I
Sbjct: 1354 QALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLR 1413
Query: 695 NKMEEFKILNDQNKALK-------SEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTV 747
K+ E + Q +A K S ++K L++E+ N+ + E+ Q + +L
Sbjct: 1414 QKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEE-NRGLGERANLGRQFLEVELDQA 1472
Query: 748 EELLETGLIQV-ATKEEELNAIRTENSSLTKEVQDLKAK---------------QNDQVS 791
E L V A E L ++ E S +E++ + AK Q ++
Sbjct: 1473 REKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQK 1532
Query: 792 FASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLE 851
+ VE+L+ E+ K VEEL + K+A+ ++ + +Q++KA++ + G Q E
Sbjct: 1533 LTAQVEQLEVFQREQT---KQVEELSK----KLADSDQASKVQQQKLKAVQAQGGESQQE 1585
Query: 852 KAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHV 911
AQ+L +++ ELQ L KE+ K +E+ + + Q+LQE+ SL+
Sbjct: 1586 -AQRLQ--AQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQ 1642
Query: 912 QEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDV---QD 968
+E + + + ++ + KE E + L A ++ E+ ++ Q L+D+ Q
Sbjct: 1643 KENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQV 1702
Query: 969 ENKLFKSQIEQLKQQ 983
KS+ Q K Q
Sbjct: 1703 ATDALKSREPQAKPQ 1717
Score = 68.2 bits (165), Expect = 5e-11
Identities = 133/653 (20%), Positives = 256/653 (39%), Gaps = 117/653 (17%)
Query: 742 EKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKK 801
E L + +++LE +++A L T +S ++ + + K A L LK
Sbjct: 79 ECLVSAQKVLEGSELELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQ-----AELAVILKF 133
Query: 802 VIHEKDGKI--KSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSIT 859
V+ +DG + +E L+ + ++L K EI ++L+K S
Sbjct: 134 VLDHEDGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSG 193
Query: 860 ------SKVQELQNLLKGKEEQMNTMKAVL-------EEKEKDLANTGKWLQDLQEENES 906
S + ++L+ + QM +K L +E E +LA K L + +
Sbjct: 194 NNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAM 253
Query: 907 LKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQL---L 963
++ + +A N K+A+S + +ELE + + E+ RL LK+ + + K+Q+ +
Sbjct: 254 MQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKI 313
Query: 964 QDVQDEN-------KLFKSQIEQLKQQ-NYQQASSFPPHEELLKVISEREKEISGLWN-- 1013
+ +EN + F S ++QL+ N +E L+ ++ EKE+S
Sbjct: 314 NQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDK 373
Query: 1014 ----------------------------------------ELDSLKDAVEHQRKKNNERQ 1033
+L++LK N + Q
Sbjct: 374 KCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQ 433
Query: 1034 QQVEAVELEAKEVLKKLFPK------------------VSVPSNLSYGE-------WLHG 1068
+VE +E E + KL + S SNLS + HG
Sbjct: 434 ARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHG 493
Query: 1069 FEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAET----EGILQKL 1124
A+ S + E+ L +++ D+ L+ + ++ ++ LA+T E Q L
Sbjct: 494 ARLTAQV----ASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGL 549
Query: 1125 QRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMEL 1184
+ VEQ + K K + + ++ +++ Q+L E E RER+ +L
Sbjct: 550 RHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEER---EASLRERDAALKQL 606
Query: 1185 EKAEMERSTYVTEVRELKAQLNETLTKLRTE----QNERQKVAGDLHKAQQSLELIQSKI 1240
E E E++ + +++ NE +T Q E+ +++ + + Q +E + +
Sbjct: 607 EALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQ 666
Query: 1241 VKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEK 1293
+A +E S + +++EKE ++ Q QLQ+ LQA+ + L K
Sbjct: 667 HEAQAQVAELELQLRSEQQKATEKERVA----QEKDQLQEQLQALKESLKVTK 715
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 154 bits (389), Expect = 5e-37
Identities = 220/1038 (21%), Positives = 439/1038 (42%), Gaps = 118/1038 (11%)
Query: 308 LKEKSGVIQDALKKSS-------------KGELTTLIHQLQEKDKLLAAVKEDAA----- 349
LKE+ +Q AL+KS E LI QLQ + + LA V+E
Sbjct: 864 LKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKS 923
Query: 350 --ATKDRCKQLTQEMMTEKERSNVVITR---MKDRIGTLEKEHNVFQNKIHVSYQETQQM 404
+ R K+L++ + E+E ++ + R ++D L+KE + + + S +E +
Sbjct: 924 KIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTT 983
Query: 405 QMKFQQVREQME---AEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE 461
+ K + + E++E +I+ L + ++++A T + L ++ +L+ L + +L +
Sbjct: 984 EHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEE-KLSSLSKANLKLEQQ 1042
Query: 462 LTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSK 521
+ E G L+QE + N E+ +L+ L+ E ++S R E + +L
Sbjct: 1043 VDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQM 1102
Query: 522 FVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQ-KRVNKEESLQMQVQDILEQNEA 580
ENE + L ++L T+ Q + L + +E+E+ R E QD+ + NE
Sbjct: 1103 NSKVENE-KGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNER 1161
Query: 581 LKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASER-DRLTSKEEELKD 639
L+ +Q+ ++LH+ + E + T SL D L E ++++
Sbjct: 1162 LEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVEN 1221
Query: 640 IQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEE 699
+Q + L+ + LQ ++ ++ + + + +K+ L E+ HE + K+++
Sbjct: 1222 LQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANA----EKLCTLYEERLHEATAKLDK 1277
Query: 700 FKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVA 759
V++ N D+ Q K E E L+ +EE
Sbjct: 1278 ---------------------VTQLAN-DLAAQKTKLWSESGEFLRRLEE---------- 1305
Query: 760 TKEEELNAIRTENSSLTKEVQDLKAK-QNDQVSFASLVEELKKVIHEKDGKIKSVEELLE 818
KE +N + E S+ T++++DL+ + + + S ++L L+K + D + EE E
Sbjct: 1306 -KEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQE 1364
Query: 819 AELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQM-- 876
+ A +T+ + E+ + + N +++ + L K EL L+ E M
Sbjct: 1365 VK----AELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKK--ELAIRLQEAAEAMGV 1418
Query: 877 -NTMKAVLEEKEKDL-ANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIV 934
N A LE L G L DL + + Q+ Q A + EE + +
Sbjct: 1419 ANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQAL 1478
Query: 935 LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPH 994
L + E++ L L + ++ + ++ ENK + +I L Q + +
Sbjct: 1479 LDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEM 1538
Query: 995 EELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKV 1054
E++ K+I E + E+ L+ + A+E R ++ Q+E +E +A E+ +KL K
Sbjct: 1539 EKVKKLIEEEKTEVQ---VTLEETEGALE--RNESKILHFQLELLEAKA-ELERKLSEK- 1591
Query: 1055 SVPSNLSYGEWLHGFEKKAK------ECMAGTSGSEEVKVLEHKLKEADEMHTL-LQLEC 1107
E + F +K + + + ++V K K ++++ + LQL C
Sbjct: 1592 --------DEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSC 1643
Query: 1108 EKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSEN 1167
+ ++E L +LQ ++ ++++D+S + ++ +E+ L+SE
Sbjct: 1644 ANRQ--VSEATKSLGQLQIQIKD----LQMQLDDSTQLNSDLKEQVAVAERRNSLLQSEL 1697
Query: 1168 KDIENLRREREH----LEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVA 1223
+D+ +L+ + E E EL +A + + T+ L +Q + + Q E ++V
Sbjct: 1698 EDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVV 1757
Query: 1224 GDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQ-QLL 1282
+ A++ K KAA + + + + E ++ QT+T LQ +L
Sbjct: 1758 QECQNAEE-------KAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLA 1810
Query: 1283 QAVNQQLTKEKEHYQVLE 1300
+A L ++ Q LE
Sbjct: 1811 EAEQMALMGSRKQIQKLE 1828
Score = 130 bits (327), Expect = 8e-30
Identities = 191/1032 (18%), Positives = 441/1032 (42%), Gaps = 178/1032 (17%)
Query: 308 LKEKSGVIQDALKKSSKGELTT------LIHQLQEKDKLLAAVKEDAAATKDRCKQLTQE 361
LK++ ++ L KS K + TT L +++ ++ ++ + A ++ +Q +
Sbjct: 962 LKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDD 1021
Query: 362 MMTEKER------SNVVITRMKDRI-GTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQ 414
+ E+E+ +N+ + + D + G LE+E N ++ +++ + + E
Sbjct: 1022 LHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESM-EN 1080
Query: 415 MEAEIAHLKQENGILRDAVSNTTNQLESKQS--AELNKLRQDYARLVNELTEKTGKLQQE 472
+E+ HL +E +S +++E+++ A+L K ++ + +L EK L+ E
Sbjct: 1081 LESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEK---LEAE 1137
Query: 473 EVQKKNAEQAATQLKVQLQEAERRWEEVQS-------YIRKRTAEHEAAQQDLQSKFVAK 525
+ E+ L L + R EEV +K+ + + +D++ +
Sbjct: 1138 RTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHF 1197
Query: 526 ENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQI 585
E SL + D+L +LE ++ L + +QK + LQ++V D+L + E
Sbjct: 1198 ETTSASLKKRHADSLA---ELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVE------ 1248
Query: 586 QQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKE-------EELK 638
Q ++ A+ ++ E LH+ A+ DK + Q + LA+++ +L S+ EE +
Sbjct: 1249 QMTRAKANAEKLCTLYEERLHEATAKLDK-VTQLANDLAAQKTKLWSESGEFLRRLEEKE 1307
Query: 639 DIQNM------NFLLKAEVQK--LQALANEQAAAAHELEKMQQ----------------- 673
+ N NF + E + L+ Q+A AH L+K Q+
Sbjct: 1308 ALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKA 1367
Query: 674 ----------------------SVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALK 711
+V + + + +++L + E + N +N +L+
Sbjct: 1368 ELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLE 1427
Query: 712 --------------SEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQ 757
S++ K+++ + K + Q K + + +K + + LL+ +
Sbjct: 1428 RARHQLQLELGDALSDLGKVRSAAARLDQKQL--QSGKALADWKQKHEESQALLDASQKE 1485
Query: 758 VATKEEEL--------------NAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVI 803
V EL +R EN +L +E+ +L + + + +E++KK+I
Sbjct: 1486 VQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLI 1545
Query: 804 HEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQ 863
E+ +++ E E L + E + + E+ K E+ + ++ K +
Sbjct: 1546 EEEKTEVQVTLEETEGALER---NESKILHFQLELLEAKAEL---------ERKLSEKDE 1593
Query: 864 ELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEAS 923
E++N + ++ ++++++ L+ + K + + ++E+ ++ + A + EA+
Sbjct: 1594 EIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQL-SCANRQVSEAT 1652
Query: 924 SASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDE-------NKLFKSQ 976
+ L +L+ +K+ + L TQL D++++ N L +S+
Sbjct: 1653 KS----------------LGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSE 1696
Query: 977 IEQLKQQNYQQASSFPPHEELLKVISER----EKEISGLWNELDSLKDAVEHQRKKNNER 1032
+E L+ Q EE L +ER + + L ++ L+ V +K+ E
Sbjct: 1697 LEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEV 1756
Query: 1033 QQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHK 1092
Q+ + E +AK K ++ L + ++ +E M T + L+ +
Sbjct: 1757 VQECQNAEEKAK---KAAIEAANLSEELKKKQDTIAHLERTRENMEQT-----ITDLQKR 1808
Query: 1093 LKEADEMHTL-LQLECEKYKSVLAETEGILQ-KLQRSVEQEENKWKVKVDESHKTIKQMQ 1150
L EA++M + + + +K +S + E EG L+ +++RS E + +++ + IK++
Sbjct: 1809 LAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLE-----RCIKELT 1863
Query: 1151 SSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLT 1210
++ L R++++ ++ L+ + ++ + ++E AE + + Y+++ ++ + +LNE
Sbjct: 1864 YQAEEDKKNLSRMQTQ---MDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKE 1920
Query: 1211 KLRTEQNERQKV 1222
+ +++ K+
Sbjct: 1921 RAEVAESQVNKL 1932
Score = 103 bits (258), Expect = 8e-22
Identities = 157/790 (19%), Positives = 342/790 (43%), Gaps = 95/790 (12%)
Query: 259 QVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDA 318
Q+E +K TK K D E A + F+ SLK ++L ++ E ++
Sbjct: 1172 QLEITKKQETKFQKLHRDMEEATLHFETTSASLKK---RHADSLAELEGQVENLQQVKQK 1228
Query: 319 LKKSSK------GELTTLIHQL----QEKDKLLAAVKE---DAAATKDRCKQLTQEMMTE 365
L+K +L T + Q+ +KL +E +A A D+ QL ++ +
Sbjct: 1229 LEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQ 1288
Query: 366 KERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAE------I 419
K T++ G + + I+ +E + + +R Q+E E +
Sbjct: 1289 K-------TKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSAL 1341
Query: 420 AHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQK-KN 478
AH Q+ RD Q E +Q + +L + +++ E+ + K + +Q+ ++
Sbjct: 1342 AHALQK--AQRDC-DLLREQYEEEQEVKA-ELHRTLSKVNAEMVQWRMKYENNVIQRTED 1397
Query: 479 AEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKF---VAKENEVQSLHSK 535
E A +L ++LQEA E R A E A+ LQ + ++ +V+S ++
Sbjct: 1398 LEDAKKELAIRLQEA----AEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAAR 1453
Query: 536 LTD-------TLVSKQQLEQRLMQLMESEQKRVNK------------EESLQMQVQDILE 576
L L +Q + L+++ QK V EES+ Q + +
Sbjct: 1454 LDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQ-ETLRR 1512
Query: 577 QNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSK--- 633
+N+ L+ +I +Q+ T E++ K+I E+ +++ T + +R SK
Sbjct: 1513 ENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILH 1572
Query: 634 ----------------EEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYV 677
E+ ++I+N + + LQ+ + +A + E+ ++++ +
Sbjct: 1573 FQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEE 1632
Query: 678 KDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSE-QPNKDVVEQMEKC 736
+++ L ++S + L Q K L+ ++ L S+ + V E+
Sbjct: 1633 DLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSL 1692
Query: 737 IQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLV 796
+Q + E L++++E E G + ++EE L A N T+ L K+ + A +
Sbjct: 1693 LQSELEDLRSLQEQTERG--RRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQ 1750
Query: 797 EELKKVIHE-KDGKIKSVEELLEAELL--KVANKEKTVQDLKQEIKALKEEIGNVQ--LE 851
+E ++V+ E ++ + K+ + +EA L ++ K+ T+ L++ + +++ I ++Q L
Sbjct: 1751 KEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLA 1810
Query: 852 KAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHV 911
+A+Q+++ +++Q L E ++ ++ LE + + A + + L+ + L
Sbjct: 1811 EAEQMALMGSRKQIQKL----ESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQA 1866
Query: 912 QEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENK 971
+E + NL +Q ++L++ ++ + +++ E + S + L +V++ +
Sbjct: 1867 EE-DKKNLSRMQ--TQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAE 1923
Query: 972 LFKSQIEQLK 981
+ +SQ+ +LK
Sbjct: 1924 VAESQVNKLK 1933
Score = 99.8 bits (247), Expect = 2e-20
Identities = 172/825 (20%), Positives = 353/825 (42%), Gaps = 133/825 (16%)
Query: 547 EQRLMQLMESEQKRVNKEESLQMQVQDILEQNEAL---KAQIQQFHS-----------QI 592
++RL ++ Q R + + ++++ Q ILE+ +AL + I+ F + +I
Sbjct: 790 DERLSKVFTLFQARA-QGKLMRIKFQKILEERDALILIQWNIRAFMAVKNWPWMRLFFKI 848
Query: 593 AAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQ 652
+S + EE+ + E+ Q+++ + +R+ L +K+ L +N + +L+ + +
Sbjct: 849 KPLVKSSEVGEEVAG-LKEECAQLQKALEKSEFQREELKAKQVSLTQEKN-DLILQLQAE 906
Query: 653 KLQALANEQAAAAHELE-KMQQSVYVKDDKIRLLEEQLQHEISNKME-EFKILNDQNKAL 710
+ + LAN + ++ K+Q VK+ R+ EE+ EI++++ + L D+ L
Sbjct: 907 Q-ETLANVEEQCEWLIKSKIQLEARVKELSERVEEEE---EINSELTARGRKLEDECFEL 962
Query: 711 KSEVQKLQT-LVSEQPNKDVVEQMEKCIQEKDEKL-----------KTVEELLETGLIQV 758
K E+ L+T LV + K E K + E+ E L K V+E + L +
Sbjct: 963 KKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDL 1022
Query: 759 ATKEEELNAIRTENSSLTKEVQDL--------KAKQNDQVSFASLVEELK---------- 800
+EE+L+++ N L ++V +L KA+ N + L LK
Sbjct: 1023 HMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLE 1082
Query: 801 -------KVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKA 853
+ + +K+ ++ + +E E VA +KTV++L+ +IK LKE++
Sbjct: 1083 SSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKL-------- 1134
Query: 854 QQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQE 913
E T +A +E + DL QDL + NE L +E
Sbjct: 1135 --------------------EAERTTRAKMERERADLT------QDLADLNERL----EE 1164
Query: 914 VAQHNLKE----ASSASQFEELEIVLKEKENELKRLEAMLKERESD----LSSKTQLLQD 965
V +L + ++F++L ++E + A LK+R +D L + + LQ
Sbjct: 1165 VGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQ 1224
Query: 966 VQDENKLFKS----QIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDA 1021
V+ + + KS +++ L + Q + E+L + ER E + +++ L +
Sbjct: 1225 VKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLAND 1284
Query: 1022 VEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAG-T 1080
+ Q+ K + E+ E L++L K ++ + LS + F ++ ++
Sbjct: 1285 LAAQKTK----------LWSESGEFLRRLEEKEALINQLSREK--SNFTRQIEDLRGQLE 1332
Query: 1081 SGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVD 1140
++ L H L++A LL+ + E+ + V AE L K+ + Q K++ V
Sbjct: 1333 KETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVI 1392
Query: 1141 ESHKTIKQMQSSFTSSEQE-LERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVR 1199
+ + ++ + QE E + N +L R R L++EL A + +
Sbjct: 1393 QRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAA 1452
Query: 1200 ELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPET 1259
L + ++ L + + ++ L +Q+ ++ + ++++K E S V ET
Sbjct: 1453 RLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKL---KNTYEESIVGQET 1509
Query: 1260 ESSEKETMSVSLNQTVTQLQQ------LLQAVNQQLTKEKEHYQV 1298
E + + ++ Q+++ ++ V + + +EK QV
Sbjct: 1510 LRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQV 1554
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 153 bits (386), Expect = 1e-36
Identities = 217/1072 (20%), Positives = 463/1072 (43%), Gaps = 150/1072 (13%)
Query: 273 TETDKENAEVKFKDFLLSLKTMMFSEDE-ALCVVDLLKEKSGVIQDALKKSSKGELTTLI 331
T+ +E+ E K+ L LK ++ DE + +++L +E+ G
Sbjct: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDG------------------ 220
Query: 332 HQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQ 391
L + +++ + C + ++ +V + K +I L +E
Sbjct: 221 ---------LHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQE----- 266
Query: 392 NKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQEN-GILRDAVSNTTNQLESKQSAELNK 450
+E + + +Q EQME E+ L+QEN +L DA S EL+
Sbjct: 267 ------LEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARS------ARMYRDELDA 314
Query: 451 LRQDYAR---LVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKR 507
LR+ R L +E++ +L E K E+ +V L+ ++++ +
Sbjct: 315 LREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARS 374
Query: 508 TAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQ-KRVNKEES 566
HE +++LQ K LH + + ++++E+ + + M E ++ + +ES
Sbjct: 375 DKLHELEKENLQLK--------AKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDES 426
Query: 567 LQM--QVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEEL-HKVIAEKDKQIKQTEDSL 623
L + +++ I +E +A + ++ TS+ +L E+ ++ + + ++++ T DS+
Sbjct: 427 LHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSV 486
Query: 624 ASERDRLTSKEEELKDIQNMNFLLKAEV-------QKLQALANEQAAAAHELEKMQQSVY 676
++ E+E + + +L+ E+ Q Q L+ + +LEK +++
Sbjct: 487 EGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLR 546
Query: 677 VKDDK-IRLLEEQLQH------------------EISNKMEEFKILNDQNKALKSEVQKL 717
++ I++LE++ +H + + +E KIL++ K S++ K+
Sbjct: 547 ENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKI 606
Query: 718 QTLVSEQPNKDVVEQMEK--CIQEKDEKLKTVE---ELLETGLIQVATKEEELNAIRTEN 772
+ Q K++ EK +E + +L +E ELL+ + + E++ A+ EN
Sbjct: 607 E-FEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQEN 665
Query: 773 SSLTKEVQDLKAKQNDQVSFASLVEELKK---VIHEKDGKIKSVEELLEAELLKVANKEK 829
S L +E + LK + + +E L+K + E++ +++ E L+ +K+A +
Sbjct: 666 SELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQL 725
Query: 830 TVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKD 889
++L+ E + LK+ ++L KA K + L+ +G + + ++ LE K
Sbjct: 726 ENKELESEKEQLKK---GLELLKAS----FKKTERLEVSYQGLDIENQRLQKTLENSNKK 778
Query: 890 LANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAML 949
+ LQDL+ EN++L+ +++E+ S+ + E+LE K E E +LE
Sbjct: 779 IQQLESELQDLEMENQTLQKNLEEL-------KISSKRLEQLEKENKSLEQETSQLEKDK 831
Query: 950 KERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEIS 1009
K+ E ENK + Q E +K EE I EKE
Sbjct: 832 KQLEK--------------ENKRLRQQAE-IKDTTL---------EENNVKIGNLEKENK 867
Query: 1010 GLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGF 1069
L E+ K++ ++ E ++ V+ ++ K ++ VS L + +
Sbjct: 868 TLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVS--EKLKTQQMNNDL 925
Query: 1070 EKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVE 1129
EK E E++ + + +L +H + +YK + ++ E L+K E
Sbjct: 926 EKLTHEL-------EKIGLNKERL-----LHDEQSTDDSRYKLLESKLESTLKKSLEIKE 973
Query: 1130 QEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEM 1189
++ + +++ES +Q++ + ++ E L+ + +D E + + + E K E
Sbjct: 974 EKIAALEARLEESTNYNQQLRQELKTVKKNYEALK-QRQDEERMVQSSPPISGEDNKWER 1032
Query: 1190 ERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTV 1249
E E+ ++K +L E T Q E+Q + L + + +Q++I+ T
Sbjct: 1033 ESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS 1092
Query: 1250 IENSDVSPETESSEKETMSVSLN-QTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
++ + + +T++++ + + +LN Q+ + + Q Q + QQ + E E+ V++
Sbjct: 1093 LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIK 1144
Score = 148 bits (374), Expect = 3e-35
Identities = 227/1097 (20%), Positives = 478/1097 (43%), Gaps = 147/1097 (13%)
Query: 258 DQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQD 317
DQ+EG + K E +KEN ++K K L M D ++ L E++ ++
Sbjct: 365 DQLEGTRARSDKL--HELEKENLQLKAK-----LHDMEMERDMDRKKIEELMEENMTLEM 417
Query: 318 ALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMK 377
A +K S E L +L++ + + + +LT + + E N +T+
Sbjct: 418 A-QKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTV 476
Query: 378 DRIGT--------------LEKEHNVFQNKIHVS---------------------YQETQ 402
+ + T +EKE+ K+ + +E
Sbjct: 477 EELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
Query: 403 QMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNEL 462
Q++ + +RE E +I L+QEN L VS+ + + A + + ++ L +
Sbjct: 537 QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESI 596
Query: 463 TEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKF 522
E + KL + E +K+ ++ K E R EE+++ + E+E Q+ + +
Sbjct: 597 KETSSKLSKIEFEKRQIKKELEHYK----EKGERAEELENELHHLEKENELLQKKITNLK 652
Query: 523 VAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALK 582
+ E ++++L + ++ ++ ++L + ++S + + ESL+ + + E+N L+
Sbjct: 653 ITCE-KIEALEQENSEL----ERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELR 707
Query: 583 AQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQN 642
++ K + K Q++ L SE+++L E
Sbjct: 708 RNVESL------------------KCASMKMAQLQLENKELESEKEQLKKGLE------- 742
Query: 643 MNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQ------HEISNK 696
LLKA +K + L E +++Q+++ + KI+ LE +LQ +
Sbjct: 743 ---LLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKN 799
Query: 697 MEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLI 756
+EE KI + + + L+ E + L+ S+ +E+ +K +++++++L+ E+ +T L
Sbjct: 800 LEELKISSKRLEQLEKENKSLEQETSQ------LEKDKKQLEKENKRLRQQAEIKDTTLE 853
Query: 757 QVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEEL 816
+ K + + EN +L+KE+ K V L +E K+++ IK++ L
Sbjct: 854 ENNVK---IGNLEKENKTLSKEIGIYK---ESCVRLKELEKENKELVKRATIDIKTLVTL 907
Query: 817 LEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQ-NLLKGKEEQ 875
E V+ K KT Q + +++ L E+ + L K + L + + LL+ K E
Sbjct: 908 RED---LVSEKLKT-QQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLE- 962
Query: 876 MNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQH--NLKEASSASQFEELEI 933
+T+K LE KE+ +A L++ N+ L+ ++ V ++ LK+ + +
Sbjct: 963 -STLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSP 1021
Query: 934 VLKEKENELKRLEAMLKERESDLSSKTQLLQ------DVQDENKLFKSQIEQLKQQN--- 984
+ ++N+ +R E+ RE L K +L++ +Q E + K+Q++QL+ QN
Sbjct: 1022 PISGEDNKWER-ESQETTREL-LKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNL 1079
Query: 985 -------YQQASSFPPHEELLKVISER-EKEISGLWNELDSLKDAVEHQRKKNNERQQQV 1036
+Q S L+ + + + E S L ++ SL + + + + +
Sbjct: 1080 QAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENEN 1139
Query: 1037 EAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEA 1096
E+V ++ +E LK L+ S+ + E LH + E + G+ LK A
Sbjct: 1140 ESV-IKEREDLKSLYD--SLIKDHEKLELLHERQASEYESLISKHGT---------LKSA 1187
Query: 1097 DEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSS 1156
+ + + E + L + +G L+ L++ ++ E+ K ++ +++H+T+
Sbjct: 1188 HKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLE-NKNHETVAAEYKKLCGE 1246
Query: 1157 EQELERLRSE-NKDIENLRREREHLEMELEKAEMERSTYVTEVRELK---AQLNETLTKL 1212
L S+ K+ E L+ + ++L+ L +++E++ E +LK QL+ T TKL
Sbjct: 1247 NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKL 1306
Query: 1213 RTEQNERQKVAGDLHKAQQS-LELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSL 1271
+ ++ G+L + + L+ IQ+ +++ + T++E + S + E+ L
Sbjct: 1307 NNQCELLSQLKGNLEEENRHLLDQIQTLMLQ---NRTLLEQNMESKDLFHVEQRQYIDKL 1363
Query: 1272 NQTVTQLQQLLQAVNQQ 1288
N+ Q ++L + + Q
Sbjct: 1364 NELRRQKEKLEEKIMDQ 1380
Score = 88.6 bits (218), Expect = 4e-17
Identities = 161/804 (20%), Positives = 322/804 (40%), Gaps = 104/804 (12%)
Query: 35 DEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVED 94
+E+L K+ K+ +K +A +++N + E +N L ++ F+L ++L E+
Sbjct: 641 NELLQKKITNLKIT---CEKIEALEQENSELERENRKLKKTLDSFKNLTFQL-ESLEKEN 696
Query: 95 DQVAPVPLNVVETSSSVRERKKK------EKKQKPVLEEQVIKESDASKIPGKKVEPVPV 148
Q+ L + S++ K E K+ +EQ+ K + K KK E + V
Sbjct: 697 SQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEV 756
Query: 149 TKQPTPPSEAAASK--KKPGQKKSKNGSDDQD---------KKVETLMVPSKRQEALP-- 195
+ Q K + +K + S+ QD K +E L + SKR E L
Sbjct: 757 SYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKE 816
Query: 196 ---LHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVI 252
L QET Q K+ K+ + + + + + N + +E+
Sbjct: 817 NKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNV--KIGNLEKENKTLSKEI- 873
Query: 253 DLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKS 312
GI K +LK E +KEN E+ K + +KT++ + DL+ EK
Sbjct: 874 ---------GIYKESCVRLK-ELEKENKEL-VKRATIDIKTLVTLRE------DLVSEKL 916
Query: 313 GVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVV 372
Q +L L H+L E K+R L E T+ R ++
Sbjct: 917 KTQQ------MNNDLEKLTHEL-----------EKIGLNKERL--LHDEQSTDDSRYKLL 957
Query: 373 ITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDA 432
++++ TL+K + + KI ++ QQ+R++++
Sbjct: 958 ESKLES---TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTV-------------- 1000
Query: 433 VSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQE 492
K++ E K RQD R+V +G+ + E + + + ++K +L E
Sbjct: 1001 ----------KKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE 1050
Query: 493 AERRWEEVQSY---IRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQR 549
ER +Q+ ++ + + E +LQ++ +A + + SL + T +L+
Sbjct: 1051 VERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVE 1110
Query: 550 LMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVI 609
L +N+ L +Q + +NE++ + + S + E LH+
Sbjct: 1111 NSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQ 1170
Query: 610 AEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELE 669
A + + + +L S L + +L+D N K +++ L+ + +
Sbjct: 1171 ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLEN 1230
Query: 670 KMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEV--QKLQTLVSEQPNK 727
K ++V + K+ ++L H S ++E ++L +K LKS + KL+ E
Sbjct: 1231 KNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFS 1290
Query: 728 DVVEQMEKCIQEKDEKLKTVEELLE--TGLIQVATKE--EELNAIRTENSSLTKEVQDLK 783
+ EQ ++ + KL ELL G ++ + +++ + +N +L + Q+++
Sbjct: 1291 KLKEQYQQ-LDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE--QNME 1347
Query: 784 AKQNDQVSFASLVEELKKVIHEKD 807
+K V +++L ++ +K+
Sbjct: 1348 SKDLFHVEQRQYIDKLNELRRQKE 1371
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 152 bits (385), Expect = 2e-36
Identities = 215/1062 (20%), Positives = 464/1062 (43%), Gaps = 93/1062 (8%)
Query: 267 GTKKLKTET-DKENAEVKFKDFLLSLKTMMFSEDEALCVVDL-LKEKSGVIQDALKKSSK 324
GT++++ E D E++ ++ ++ SE+E L + L+EK + +K+ S
Sbjct: 41 GTEEVEAELPDSRTKEIE------AIHAILRSENERLKKLCTDLEEKHEASEIQIKQQS- 93
Query: 325 GELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLE 384
T+ +QLQ+K+ ++ +K A +D+ +L + + V T
Sbjct: 94 ---TSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGI 150
Query: 385 KEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQ-LESK 443
H + + + + + QQ ++ E++ L+ E G R + Q ++
Sbjct: 151 SHHPSAFHDDDMDFGDI----ISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNS 206
Query: 444 QSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNA-EQAATQL----KVQLQEAERRWE 498
+E+ KL+ L +++ Q E +NA +Q T++ + +L + E R E
Sbjct: 207 DQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIE 266
Query: 499 EVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQ 558
E+++ +++ + + DL SK + +Q L + ++ +QLE ++ + +
Sbjct: 267 ELENLLQQGGSG--VIETDL-SKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLS 323
Query: 559 KRVN-------KEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEEL--HKVI 609
N ++E L ++ + I+E+ E LK + + Q+ E +
Sbjct: 324 SAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSAS 383
Query: 610 AEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELE 669
E+ +++Q +E RL+S ++ + N LK +++ L E++ + E E
Sbjct: 384 VEEVFRLQQALSDAENEIMRLSSLNQD-NSLAEDNLKLK---MRIEVLEKEKSLLSQEKE 439
Query: 670 KMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDV 729
++Q S+ +++ +++ +IS E L+D L+++ Q+L +SE+
Sbjct: 440 ELQMSLLKLNNEYEVIKSTATRDISLDSE----LHDLRLNLEAKEQELNQSISEKETLIA 495
Query: 730 -VEQMEKCIQEKDEKLKTVEELLET----GLIQVATKEEELNAIRTENSSLTKEVQDLKA 784
+E++++ QE + + +++ L G ++ +++LN + L + D+
Sbjct: 496 EIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITK 555
Query: 785 KQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQ----DLKQEIKA 840
+ + Q E +H K++ E L +L K ++Q +LK+ I+
Sbjct: 556 ELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQ 615
Query: 841 LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 900
+EE+ ++ E Q L+ S LLK +E ++ +K L E E+ N K D+
Sbjct: 616 NEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDV 675
Query: 901 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLS-SK 959
+ ENE L ++V +H L+E + + L EK ++ L+ E E++L +K
Sbjct: 676 KMENEKLVLACEDV-RHQLEECLAGNNQLSL-----EKNTIVETLKMEKGEIEAELCWAK 729
Query: 960 TQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLK 1019
+LL++ NK K+ E +N ++ HE L+K+ +++ EI+ L ++ +
Sbjct: 730 KRLLEEA---NKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMD 786
Query: 1020 DAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAG 1079
+H+ K+ V + LE ++ L +L K + F +K KE
Sbjct: 787 --TDHKETKD------VLSSSLEEQKQLTQLINKKEI------------FIEKLKE--RS 824
Query: 1080 TSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKV 1139
+ EE+ L++ + + ++ + S+ E + ++L+R E++ V
Sbjct: 825 SKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVAD 884
Query: 1140 DESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVR 1199
++ ++ ++ S + E L E K + + ++ +M+L ++ E+ + E R
Sbjct: 885 PKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFR 944
Query: 1200 ELKAQLNETLTKLRTEQNER--------QKVAGDLHKAQQSLELIQSKIVKAAGDTTV-I 1250
Q+N T T+L E++E +++ LH+ +Q ++ S I + ++ I
Sbjct: 945 YQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNI 1004
Query: 1251 ENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKE 1292
EN + +E E + + + ++ +LL N LTK+
Sbjct: 1005 ENGSEKHDLSKAETERLVKGIKERELEI-KLLNEKNISLTKQ 1045
Score = 143 bits (360), Expect = 1e-33
Identities = 250/1258 (19%), Positives = 530/1258 (42%), Gaps = 157/1258 (12%)
Query: 132 ESDASKI--PGKKVEPVPVTK-QPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPS 188
E+D SKI K ++ + + K + T E K K KK + +D+D +
Sbjct: 281 ETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRD-------ILR 333
Query: 189 KRQEALPLHQETKQESGSGKKKASSKKQ----KTENVFVDEPLIHATTYIPLMDNADSSP 244
+ QE L + + E K SK Q K + ++ I L +A
Sbjct: 334 REQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERI-------LAQSASVEE 386
Query: 245 VVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCV 304
V ++ + D I + + ++N ++K + +L + + S+++
Sbjct: 387 VFRLQQALS----DAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQ 442
Query: 305 VDLLKE-------KSGVIQDA--------LKKSSKGELTTLIHQLQEKDKLLAAVKEDAA 349
+ LLK KS +D L+ + + + L + EK+ L+A ++E
Sbjct: 443 MSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDR 502
Query: 350 ATKDRCKQLT---QEMMTEKERSNVVITRMKDRIGTLEKE-HNVFQNKIHVSYQETQQMQ 405
++ K + ++ ++ + +I+++K + +K H + +K+ ++ + Q
Sbjct: 503 QNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQ-- 560
Query: 406 MKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELN--KLRQDYARLVNELT 463
K + ++ ++ HL ++ L D V N +QL Q + ++ K + + +
Sbjct: 561 -KEKLIQSEVALNDLHLTKQK--LEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNE 617
Query: 464 EKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKF- 522
E+ +++ E +Q N + + L+E E EV++ +++ +E E ++L+
Sbjct: 618 EELSRIRNELMQSLNQDSNSNFKDTLLKEREA---EVRN-LKQNLSELEQLNENLKKVAF 673
Query: 523 -VAKENE-----VQSLHSKLTDTLVSKQQLEQRLMQLMES-EQKRVNKEESLQMQVQDIL 575
V ENE + + +L + L QL ++E+ + ++ E L + +L
Sbjct: 674 DVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLL 733
Query: 576 EQNEALKAQIQQFHSQIAAQTSASVLAEELHKV---------IAEKDKQIKQTEDSLASE 626
E+ + I++ + TSA L E H + IAE K I+Q +
Sbjct: 734 EEANKYEKTIEELSNARNLNTSALQLEHE-HLIKLNQKKDMEIAELKKNIEQMDTDHKET 792
Query: 627 RDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLE 686
+D L+S EE K + + + K E+ ++ L + EL+K Q++ K++ +R
Sbjct: 793 KDVLSSSLEEQKQLTQL--INKKEIF-IEKLKERSSKLQEELDKYSQALR-KNEILRQTI 848
Query: 687 EQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKT 746
E+ + + EE L ++ + L+ E + + + V E + Q L T
Sbjct: 849 EEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQ-----LNT 903
Query: 747 VEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELK----KV 802
++E LE + + I +N S + +Q L+ ++ + F E++ ++
Sbjct: 904 IKEHLEEEI------KHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQL 957
Query: 803 IHEKDGKIKSVEELLEAELLKVANKEKTVQ----DLKQEIKALKEEIGNVQ----LEKAQ 854
EKD +IKS+++ +E ++ + + +Q D+ QE K I N L KA+
Sbjct: 958 FLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAE 1017
Query: 855 QLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKA----- 909
+ ++E + +K E+ ++ +++ KD GK Q +Q+++ ++A
Sbjct: 1018 TERLVKGIKERELEIKLLNEKNISLTKQIDQLSKD--EVGKLTQIIQQKDLEIQALHARI 1075
Query: 910 ----HVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQD 965
H Q+V + + A + E++ VL EK E L+ + +++K L
Sbjct: 1076 SSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIK 1135
Query: 966 VQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQ 1025
+QDENK ++ E Q +++ + L ++I E++ EI L + +L AV
Sbjct: 1136 LQDENKKLSTRFESSGQDMFRETI-----QNLSRIIREKDIEIDALSQKCQTLL-AVLQT 1189
Query: 1026 RKKNNE----RQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTS 1081
NE Q E + L+ ++ LK+ K+ EW + ++
Sbjct: 1190 SSTGNEAGGVNSNQFEEL-LQERDKLKQQVKKME--------EWKQQVMTTVQNMQHESA 1240
Query: 1082 G-SEEVKVLEHKLKEADEMHTLLQLE-------CEKYKSVLAETEGILQKLQRSVEQEEN 1133
EE+ L+ ++ + ++ LQ++ E+ ++ L L ++Q S+ Q N
Sbjct: 1241 QLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCN 1300
Query: 1134 KWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELE---KAEME 1190
+ + + Q+ S+ + Q E LR+ ++ L E L+ ELE K+ E
Sbjct: 1301 TKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEV--LSESSELLQQELEELRKSLQE 1358
Query: 1191 RSTYVTEVRELKAQLNETLTKL-RTEQNERQKVAGDLHKAQQSLELIQ------SKIVKA 1243
+ + ++E +L++++ E+ E ++ ++ + ++ +++Q ++KA
Sbjct: 1359 KDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKA 1418
Query: 1244 AGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEK-EHYQVLE 1300
D + N + + + +E L Q VT L++ + + + K K E+ +++E
Sbjct: 1419 KSDQLLSSNENFTNKVNENE------LLRQAVTNLKERILILEMDIGKLKGENEKIVE 1470
Score = 134 bits (338), Expect = 4e-31
Identities = 277/1412 (19%), Positives = 592/1412 (41%), Gaps = 225/1412 (15%)
Query: 35 DEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESD-----------SESVPRD 83
D + ++++EQ + + ++ E K + ++Q + +SD S SV
Sbjct: 328 DRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEV 387
Query: 84 FKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQ---VIKESDASKIPG 140
F+L AL+ ++++ + L+ + +S+ E K K + VLE++ + +E + ++
Sbjct: 388 FRLQQALSDAENEI--MRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSL 445
Query: 141 KKVEPVPVTKQPTPPSEAAASKK---------KPGQKKSKNGSDDQDKKVETLMVPSKRQ 191
K+ + T + + + Q+ +++ S+ + E + + Q
Sbjct: 446 LKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQ 505
Query: 192 EA-----LPLHQETKQESGSG------KKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
EA L Q +KQ++ K+ + +K++ + D+ I +
Sbjct: 506 EATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLI 565
Query: 241 DSSPVVDKREVIDLLKPDQVEGI--QKSGTKKLKTETDKENAEVKF-----KDFLLSLKT 293
S ++ + D+VE + Q + +++ KEN E+K ++ L ++
Sbjct: 566 QSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRN 625
Query: 294 MMF---SEDEALCVVD-LLKEKSGVIQDALKKSSKGELTTLIHQLQ--------EKDKLL 341
+ ++D D LLKE+ +++ K + EL L L+ E +KL+
Sbjct: 626 ELMQSLNQDSNSNFKDTLLKEREAEVRNL--KQNLSELEQLNENLKKVAFDVKMENEKLV 683
Query: 342 AAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLE-----------KEHNVF 390
A ED + C ++ EK N ++ +K G +E +E N +
Sbjct: 684 LAC-EDVRHQLEECLAGNNQLSLEK---NTIVETLKMEKGEIEAELCWAKKRLLEEANKY 739
Query: 391 QNKI----HVSYQETQQMQMKFQ---QVREQMEAEIAHLKQ-------ENGILRDAVSNT 436
+ I + T +Q++ + ++ ++ + EIA LK+ ++ +D +S++
Sbjct: 740 EKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSS 799
Query: 437 TN------QLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQL 490
QL +K+ + KL++ ++L EL + + L++ E+ ++ E+ L
Sbjct: 800 LEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMK 859
Query: 491 QEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRL 550
+E EE++ +++ A +EV L++ +++ L
Sbjct: 860 EENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNT-----------IKEHL 908
Query: 551 MQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIA 610
+ ++ QK + + +MQ+ L++ + + + H Q+ A + ++
Sbjct: 909 EEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHT---------QLFL 959
Query: 611 EKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEK 670
EKD++IK + ++ + +L EE +DIQ N + E K+Q+L E + H+L K
Sbjct: 960 EKDEEIKSLQKTIEQIKTQL---HEERQDIQTDNSDIFQET-KVQSLNIENGSEKHDLSK 1015
Query: 671 MQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQP----- 725
+ VK K R LE +L +E + + ++ K EV KL ++ ++
Sbjct: 1016 AETERLVKGIKERELEIKLLNE-----KNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQA 1070
Query: 726 ----------NKDVV---EQMEKCIQEKDEKLKTVEELLETG----------LIQVATKE 762
+DVV +Q++ E+++ + E + VA KE
Sbjct: 1071 LHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKE 1130
Query: 763 EELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELL 822
L ++ EN L+ + + Q F ++ L ++I EKD +I ++ + + LL
Sbjct: 1131 AALIKLQDENKKLSTRFES-----SGQDMFRETIQNLSRIIREKDIEIDALSQKCQT-LL 1184
Query: 823 KVANKEKT-----------VQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKG 871
V T ++L QE LK+++ ++ K Q ++ +Q L+
Sbjct: 1185 AVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQE 1244
Query: 872 KEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENES-LKAHVQEVAQ--HNLKEASSASQF 928
+ Q+ V + L L E+NE+ LK QE+AQ H++ + +
Sbjct: 1245 ELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDL 1304
Query: 929 --EELEIVLKEKENELKRLEAMLKERESDL--SSKTQLLQDVQDENKLFKSQIEQLKQQN 984
+L+I+ + + ++L + ++ +SK+++L + ++L + ++E+L++
Sbjct: 1305 LLGKLDIISPQLSSA-----SLLTPQSAECLRASKSEVLSE---SSELLQQELEELRK-- 1354
Query: 985 YQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAK 1044
S + ++ + E +S DS+ E +RK++ + +++ ++ E +
Sbjct: 1355 -----SLQEKDATIRTLQENNHRLS------DSIAATSELERKEHEQTDSEIKQLK-EKQ 1402
Query: 1045 EVLKKLFPKVSVPSNLSYGEWL---HGFEKKAKEC----MAGTSGSEEVKVLEH---KLK 1094
+VL+KL + + + L F K E A T+ E + +LE KLK
Sbjct: 1403 DVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLK 1462
Query: 1095 EADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFT 1154
+E E L ET + R E E + K K + +K+ + T
Sbjct: 1463 GENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKT 1522
Query: 1155 SS-EQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELK---AQLNETLT 1210
Q L ++S + ++ER+ + + L++ +ME + EV+ L+ + N+ L
Sbjct: 1523 GELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELE 1582
Query: 1211 KLRTEQNE------RQKVAGDLHKA--QQSLELIQSKIVKAAGDTTVIENS--DVSPETE 1260
+LR E R+ +A + +A ++ + +++ K+V + + +EN+ S + E
Sbjct: 1583 RLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSS---SNAMENASHQASVQVE 1639
Query: 1261 SSEKETMSVSLNQTVTQLQQLLQAVNQQLTKE 1292
S +++ VS + T LQ +V+Q+ K+
Sbjct: 1640 SLQEQLNVVSKQRDETALQ---LSVSQEQVKQ 1668
Score = 101 bits (251), Expect = 5e-21
Identities = 206/1087 (18%), Positives = 461/1087 (42%), Gaps = 159/1087 (14%)
Query: 63 KKKEIQNGNLHESDSESVPRDFKLS-DALAVEDDQVAPV----PLNVVETSSSVRERKKK 117
KK+ ++ N +E E + L+ AL +E + + + + + E ++ +
Sbjct: 729 KKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTD 788
Query: 118 EKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKS---KNGS 174
K+ K VL + ++ +++ KK + K+ + + K +K+ +
Sbjct: 789 HKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTI 848
Query: 175 DDQDKKVETLMVPSKR-QEALPLHQETKQESG---------SGKKKASSKKQ-KTENVFV 223
+++D+ + ++ + QE L +E + + S + AS Q T +
Sbjct: 849 EEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHL 908
Query: 224 DEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTK-KLKTETDKENAEV 282
+E + H I + + + +E + + + Q + T +L E D+E +
Sbjct: 909 EEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSL 968
Query: 283 KFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQ--EKDKL 340
+ + +KT + E + D+ + S + Q+ +S E + H L E ++L
Sbjct: 969 Q--KTIEQIKTQLHEERQ-----DIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERL 1021
Query: 341 LAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE 400
+ +KE ++L +++ EK N+ +T+ D++ ++++ Q
Sbjct: 1022 VKGIKE---------RELEIKLLNEK---NISLTKQIDQLS---------KDEVGKLTQI 1060
Query: 401 TQQMQMKFQQVREQMEA-----EIAHLKQE---NGILRDAVSNTTNQLESKQSAELNKLR 452
QQ ++ Q + ++ + ++ +L+Q+ + R+ V N+ ++ E + L+
Sbjct: 1061 IQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNE----KTRENSHLK 1116
Query: 453 QDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRW-EEVQSYIRKRTAEH 511
+Y ++++ + K L + + + K + +T+ + Q+ R + + IR++ E
Sbjct: 1117 TEYHKMMDIVAAKEAALIKLQDENK---KLSTRFESSGQDMFRETIQNLSRIIREKDIEI 1173
Query: 512 EAAQQDLQSKFVAKE-----NEVQSLHS-KLTDTLVSKQQLEQRLMQLMESEQKRVNKEE 565
+A Q Q+ + NE ++S + + L + +L+Q++ ++ E +Q+ + +
Sbjct: 1174 DALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQ 1233
Query: 566 SLQMQVQDILEQNEALKAQI---QQFHSQIAAQTSASVLAEELH----KVIAEKDKQIKQ 618
++Q + + E+ L+AQ+ +S++ + + + E + K ++ Q++
Sbjct: 1234 NMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQH 1293
Query: 619 TEDSLASERDRLTSKEEELKDIQNMNFLLKAE------VQKLQALANEQAAAAHELEKMQ 672
+ L + +D L K + + + LL + K + L+ ELE+++
Sbjct: 1294 SIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELR 1353
Query: 673 QSVYVKDDKIRLLEEQLQHEISNKM--------EEFKILNDQNKALKSEVQKLQTLVSEQ 724
+S+ KD IR L+E H +S+ + +E + + + K LK + LQ L+ E
Sbjct: 1354 KSLQEKDATIRTLQEN-NHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKE- 1411
Query: 725 PNKDVV------------EQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTEN 772
KD++ E + E + + V L E LI E ++ ++ EN
Sbjct: 1412 --KDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILIL----EMDIGKLKGEN 1465
Query: 773 SSLTKEVQ----DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLE-------AEL 821
+ + + + +A Q + F+ ++ E + H K + E+LL+ EL
Sbjct: 1466 EKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGEL 1525
Query: 822 LKVAN-----KEKTV---QDLKQEIKALKEEI-------GNVQLEKAQQLSITSKVQELQ 866
++ N +EKTV Q+ Q + ALK++ VQ + ++ +++ L+
Sbjct: 1526 NQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLR 1585
Query: 867 NLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSAS 926
N L E+ E++E L L EE ++ E A H +
Sbjct: 1586 NHLLESEDSYTREALAAEDREAKLRKKVTVL----EEKLVSSSNAMENASHQASVQVESL 1641
Query: 927 QFEELEIVLKEKENELKRL---EAMLKERESDLSSKTQLLQDVQDENK-LFKSQIEQLKQ 982
Q E+L +V K+++ +L + +K+ L++ +L+ Q E K ++ +++E+ KQ
Sbjct: 1642 Q-EQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQ 1700
Query: 983 QNYQQASSFPPHEELLKVISERE---------KEISGLWNELDSLKDAVEHQRKKNNERQ 1033
+ + E KVIS +E S L +LD ++ +E +++N RQ
Sbjct: 1701 LIAEWKKNAENLEG--KVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQ 1758
Query: 1034 QQVEAVE 1040
+ ++ V+
Sbjct: 1759 EMLDDVQ 1765
Score = 99.4 bits (246), Expect = 2e-20
Identities = 192/1026 (18%), Positives = 419/1026 (40%), Gaps = 103/1026 (10%)
Query: 30 KETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDA 89
KET +VL+ EQK + +KK+ +K K++ + + S+++ ++ L
Sbjct: 790 KET--KDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQT 847
Query: 90 LAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVT 149
+ +D + + + ++++ + PV + + + D+ +V +
Sbjct: 848 IEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTL---DSVTELASEVSQLNTI 904
Query: 150 KQPTPPSEAAASKKKPGQKKSK----NGSDDQDKKVETLMVPSKRQEALPLHQETKQESG 205
K+ K Q +SK +Q K+++ ++ A +++
Sbjct: 905 KEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEE 964
Query: 206 SGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQK 265
+ + ++ KT+ +H DN+D K + +++ + + K
Sbjct: 965 IKSLQKTIEQIKTQ--------LHEERQDIQTDNSDIFQET-KVQSLNIENGSEKHDLSK 1015
Query: 266 SGTKKLKTETDKENAEVKF---KDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKS 322
+ T++L + E+K K+ L+ + S+DE + ++++K IQ +
Sbjct: 1016 AETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARI 1075
Query: 323 SKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGT 382
S T + LQ++ + A +E A + + + TE + ++ + +
Sbjct: 1076 SSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIK 1135
Query: 383 LEKEHNVFQNKIHVSYQET-QQMQMKFQQVREQMEAEIAHLKQENGILRDAV--SNTTNQ 439
L+ E+ + S Q+ ++ ++ + + EI L Q+ L + S+T N+
Sbjct: 1136 LQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNE 1195
Query: 440 LESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEE 499
S + +L Q+ +L ++ + QQ +N + + QL+ +L + + +
Sbjct: 1196 AGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLV 1255
Query: 500 VQSYIRKRTAEHEAAQQDLQSKFVAKEN------EVQSLHSKLTDT---------LVSKQ 544
K ++ Q + +N +VQ +L +T ++S Q
Sbjct: 1256 DSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQ 1315
Query: 545 QLEQRLMQLMESEQKRVNKEESL-------QMQVQDI---LEQNEALKAQIQQFHSQIAA 594
L+ +E R +K E L Q +++++ L++ +A +Q+ + +++
Sbjct: 1316 LSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSD 1375
Query: 595 QTSA-SVLAEELHKVIAEKDKQIKQTEDSLA-----------SERDRLTSKEEELKDIQN 642
+A S L + H+ + KQ+K+ +D L ++ D+L S E + N
Sbjct: 1376 SIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVN 1435
Query: 643 MNFLLKAEVQKLQA----LANEQAAAAHELEKMQQSVYVKDDKIRLLEE-QLQHEISNKM 697
N LL+ V L+ L + E EK+ ++ K+ + + L+E ++ + +
Sbjct: 1436 ENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLRE 1495
Query: 698 EEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQ 757
+EF+ + + KAL E Q L+ EQ + Q+ ++ EK ++ E +
Sbjct: 1496 KEFECHSMKEKALAFE-QLLKE--KEQGKTGELNQLLNAVKSMQEKTVVFQQ--ERDQVM 1550
Query: 758 VATKEEELNAIRTENSSLTKEVQDLKAKQ-----------NDQVSFASLVEELKKVIHEK 806
+A K++++ EN++L EVQ L+ K+ N + ++
Sbjct: 1551 LALKQKQM-----ENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDR 1605
Query: 807 DGKIKSVEELLEAELLKVANK-EKTVQDLKQEIKALKEEIGNVQLEK---AQQLSITSK- 861
+ K++ +LE +L+ +N E ++++L+E++ V ++ A QLS++ +
Sbjct: 1606 EAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQ 1665
Query: 862 -------VQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEV 914
+ LQ +L+ +++ M + EK+K L +W ++ E E +QE
Sbjct: 1666 VKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLI--AEWKKNA-ENLEGKVISLQEC 1722
Query: 915 AQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFK 974
SAS+ E V +E+ ELKR + +E D+ K L + E K+ K
Sbjct: 1723 LDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLAN-SSEGKVDK 1781
Query: 975 SQIEQL 980
+ L
Sbjct: 1782 VLMRNL 1787
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 152 bits (384), Expect = 2e-36
Identities = 219/1072 (20%), Positives = 464/1072 (43%), Gaps = 151/1072 (14%)
Query: 273 TETDKENAEVKFKDFLLSLKTMMFSEDE-ALCVVDLLKEKSGVIQDALKKSSKGELTTLI 331
T+ +E+ E K+ L LK ++ DE + +++L +E+ G
Sbjct: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDG------------------ 220
Query: 332 HQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQ 391
L + +++ + C + ++ +V + K +I L +E
Sbjct: 221 ---------LHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQE----- 266
Query: 392 NKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQEN-GILRDAVSNTTNQLESKQSAELNK 450
+E + + +Q EQME E+ L+QEN +L DA S EL+
Sbjct: 267 ------LEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARS------ARMYRDELDA 314
Query: 451 LRQDYAR---LVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKR 507
LR+ R L +E++ +L E K E+ +V L+ ++++ +
Sbjct: 315 LREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARS 374
Query: 508 TAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQ-KRVNKEES 566
HE +++LQ K LH + + ++++E+ + + M E ++ + +ES
Sbjct: 375 DKLHELEKENLQLK--------AKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDES 426
Query: 567 LQM--QVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEEL-HKVIAEKDKQIKQTEDSL 623
L + +++ I +E +A + ++ TS+ +L E+ ++ + + ++++ T DS+
Sbjct: 427 LHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSV 486
Query: 624 ASERDRLTSKEEELKDIQNMNFLLKAEV-------QKLQALANEQAAAAHELEKMQQSVY 676
++ E+E + + +L+ E+ Q Q L+ + +LEK +++
Sbjct: 487 EGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLR 546
Query: 677 VKDDK-IRLLEEQLQH------------------EISNKMEEFKILNDQNKALKSEVQKL 717
++ I++LE++ +H + + +E KIL++ K S++ K+
Sbjct: 547 ENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKI 606
Query: 718 QTLVSEQPNKDVVEQMEK--CIQEKDEKLKTVE---ELLETGLIQVATKEEELNAIRTEN 772
+ Q K++ EK +E + +L +E ELL+ + + E++ A+ EN
Sbjct: 607 E-FEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQEN 665
Query: 773 SSLTKEVQDLKAKQNDQVSFASLVEELKK---VIHEKDGKIKSVEELLEAELLKVANKEK 829
S L +E + LK + + +E L+K + E++ +++ E L+ +K+A +
Sbjct: 666 SELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQL 725
Query: 830 TVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKD 889
++L+ E + LK+ ++L KA K + L+ +G + + ++ LE K
Sbjct: 726 ENKELESEKEQLKK---GLELLKAS----FKKTERLEVSYQGLDIENQRLQKTLENSNKK 778
Query: 890 LANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAML 949
+ LQDL+ EN++L+ +++E+ S+ + E+LE K E E +LE
Sbjct: 779 IQQLESELQDLEMENQTLQKNLEEL-------KISSKRLEQLEKENKSLEQETSQLEKDK 831
Query: 950 KERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEIS 1009
K+ E ENK + Q E +K EE I EKE
Sbjct: 832 KQLEK--------------ENKRLRQQAE-IKDTTL---------EENNVKIGNLEKENK 867
Query: 1010 GLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGF 1069
L E+ K++ ++ E ++ V+ ++ K ++ VS L + +
Sbjct: 868 TLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVS--EKLKTQQMNNDL 925
Query: 1070 EKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVE 1129
EK E E++ + + +L DE T ++YK + ++ E L+K E
Sbjct: 926 EKLTHEL-------EKIGLNKERLLH-DEQST-----DDRYKLLESKLESTLKKSLEIKE 972
Query: 1130 QEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEM 1189
++ + +++ES +Q++ + ++ E L+ + +D E + + + E K E
Sbjct: 973 EKIAALEARLEESTNYNQQLRQELKTVKKNYEALK-QRQDEERMVQSSPPISGEDNKWER 1031
Query: 1190 ERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTV 1249
E E+ ++K +L E T Q E+Q + L + + +Q++I+ T
Sbjct: 1032 ESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS 1091
Query: 1250 IENSDVSPETESSEKETMSVSLN-QTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
++ + + +T++++ + + +LN Q+ + + Q Q + QQ + E E+ V++
Sbjct: 1092 LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIK 1143
Score = 152 bits (384), Expect = 2e-36
Identities = 227/1096 (20%), Positives = 477/1096 (43%), Gaps = 146/1096 (13%)
Query: 258 DQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQD 317
DQ+EG + K E +KEN ++K K L M D ++ L E++ ++
Sbjct: 365 DQLEGTRARSDKL--HELEKENLQLKAK-----LHDMEMERDMDRKKIEELMEENMTLEM 417
Query: 318 ALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMK 377
A +K S E L +L++ + + + +LT + + E N +T+
Sbjct: 418 A-QKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTV 476
Query: 378 DRIGT--------------LEKEHNVFQNKIHVS---------------------YQETQ 402
+ + T +EKE+ K+ + +E
Sbjct: 477 EELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
Query: 403 QMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNEL 462
Q++ + +RE E +I L+QEN L VS+ + + A + + ++ L +
Sbjct: 537 QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESI 596
Query: 463 TEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKF 522
E + KL + E +K+ ++ K E R EE+++ + E+E Q+ + +
Sbjct: 597 KETSSKLSKIEFEKRQIKKELEHYK----EKGERAEELENELHHLEKENELLQKKITNLK 652
Query: 523 VAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALK 582
+ E ++++L + ++ ++ ++L + ++S + + ESL+ + + E+N L+
Sbjct: 653 ITCE-KIEALEQENSEL----ERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELR 707
Query: 583 AQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQN 642
++ K + K Q++ L SE+++L E
Sbjct: 708 RNVESL------------------KCASMKMAQLQLENKELESEKEQLKKGLE------- 742
Query: 643 MNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQ------HEISNK 696
LLKA +K + L E +++Q+++ + KI+ LE +LQ +
Sbjct: 743 ---LLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKN 799
Query: 697 MEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLI 756
+EE KI + + + L+ E + L+ S+ +E+ +K +++++++L+ E+ +T L
Sbjct: 800 LEELKISSKRLEQLEKENKSLEQETSQ------LEKDKKQLEKENKRLRQQAEIKDTTLE 853
Query: 757 QVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEEL 816
+ K + + EN +L+KE+ K V L +E K+++ IK++ L
Sbjct: 854 ENNVK---IGNLEKENKTLSKEIGIYK---ESCVRLKELEKENKELVKRATIDIKTLVTL 907
Query: 817 LEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQM 876
E V+ K KT Q + +++ L E+ + L K + L + LL+ K E
Sbjct: 908 RED---LVSEKLKT-QQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLE-- 961
Query: 877 NTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQH--NLKEASSASQFEELEIV 934
+T+K LE KE+ +A L++ N+ L+ ++ V ++ LK+ + +
Sbjct: 962 STLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPP 1021
Query: 935 LKEKENELKRLEAMLKERESDLSSKTQLLQ------DVQDENKLFKSQIEQLKQQN---- 984
+ ++N+ +R E+ RE L K +L++ +Q E + K+Q++QL+ QN
Sbjct: 1022 ISGEDNKWER-ESQETTREL-LKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ 1079
Query: 985 ------YQQASSFPPHEELLKVISER-EKEISGLWNELDSLKDAVEHQRKKNNERQQQVE 1037
+Q S L+ + + + E S L ++ SL + + + + + E
Sbjct: 1080 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE 1139
Query: 1038 AVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEAD 1097
+V ++ +E LK L+ S+ + E LH + E + G+ LK A
Sbjct: 1140 SV-IKEREDLKSLYD--SLIKDHEKLELLHERQASEYESLISKHGT---------LKSAH 1187
Query: 1098 EMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSE 1157
+ + + E + L + +G L+ L++ ++ E+ K ++ +++H+T+
Sbjct: 1188 KNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLE-NKNHETVAAEYKKLCGEN 1246
Query: 1158 QELERLRSE-NKDIENLRREREHLEMELEKAEMERSTYVTEVRELK---AQLNETLTKLR 1213
L S+ K+ E L+ + ++L+ L +++E++ E +LK QL+ T TKL
Sbjct: 1247 DRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLN 1306
Query: 1214 TEQNERQKVAGDLHKAQQS-LELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLN 1272
+ ++ G+L + + L+ IQ+ +++ + T++E + S + E+ LN
Sbjct: 1307 NQCELLSQLKGNLEEENRHLLDQIQTLMLQ---NRTLLEQNMESKDLFHVEQRQYIDKLN 1363
Query: 1273 QTVTQLQQLLQAVNQQ 1288
+ Q ++L + + Q
Sbjct: 1364 ELRRQKEKLEEKIMDQ 1379
Score = 92.0 bits (227), Expect = 3e-18
Identities = 169/808 (20%), Positives = 332/808 (41%), Gaps = 113/808 (13%)
Query: 35 DEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVED 94
+E+L K+ K+ +K +A +++N + E +N L ++ F+L ++L E+
Sbjct: 641 NELLQKKITNLKIT---CEKIEALEQENSELERENRKLKKTLDSFKNLTFQL-ESLEKEN 696
Query: 95 DQVAPVPLNVVETSSSVRERKKK------EKKQKPVLEEQVIKESDASKIPGKKVEPVPV 148
Q+ L + S++ K E K+ +EQ+ K + K KK E + V
Sbjct: 697 SQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEV 756
Query: 149 TKQPTPPSEAAASK--KKPGQKKSKNGSDDQD---------KKVETLMVPSKRQEALP-- 195
+ Q K + +K + S+ QD K +E L + SKR E L
Sbjct: 757 SYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKE 816
Query: 196 ---LHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVI 252
L QET Q K+ K+ + + + + + N + +E+
Sbjct: 817 NKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNV--KIGNLEKENKTLSKEI- 873
Query: 253 DLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKS 312
GI K +LK E +KEN E+ K + +KT++ + DL+ EK
Sbjct: 874 ---------GIYKESCVRLK-ELEKENKEL-VKRATIDIKTLVTLRE------DLVSEKL 916
Query: 313 GVIQDALKKSSKGELTTLIHQLQE----KDKLLAAVKEDAAATKDRCKQLTQEMMTEKER 368
Q +L L H+L++ K++LL D +T DR K L ++ + ++
Sbjct: 917 KTQQ------MNNDLEKLTHELEKIGLNKERLL----HDEQSTDDRYKLLESKLESTLKK 966
Query: 369 SNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGI 428
S + +++I LE ++ S QQ++ + + V++ EA LKQ
Sbjct: 967 SLEI---KEEKIAALEA-------RLEESTNYNQQLRQELKTVKKNYEA----LKQRQDE 1012
Query: 429 LRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKV 488
R S+ S E NK ++ EL + +L + E + LK
Sbjct: 1013 ERMVQSSPPI------SGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKT 1066
Query: 489 QLQEAERRWEEVQSYI---RKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQ 545
QL++ E + +Q+ I +++T + LQ++ + E +L+S+ T + Q
Sbjct: 1067 QLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQ 1126
Query: 546 LEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEEL 605
L + L + + + E L+ +++ +E L+ H + A++ + +
Sbjct: 1127 LLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLEL----LHERQASEYESLI---SK 1179
Query: 606 HKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAA 665
H + K ++ L ++L ++ +L+D++ M LK E +K+ A
Sbjct: 1180 HGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKM---LKVEQEKMLLENKNHETVA 1236
Query: 666 HELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEV--QKLQTLVSE 723
E +K+ ++L H S ++E ++L +K LKS + KL+ E
Sbjct: 1237 AEYKKLCGE-----------NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE 1285
Query: 724 QPNKDVVEQMEKCIQEKDEKLKTVEELLE--TGLIQVATKE--EELNAIRTENSSLTKEV 779
+ EQ ++ + KL ELL G ++ + +++ + +N +L +
Sbjct: 1286 AEFSKLKEQYQQ-LDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE-- 1342
Query: 780 QDLKAKQNDQVSFASLVEELKKVIHEKD 807
Q++++K V +++L ++ +K+
Sbjct: 1343 QNMESKDLFHVEQRQYIDKLNELRRQKE 1370
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 151 bits (381), Expect = 4e-36
Identities = 254/1329 (19%), Positives = 558/1329 (41%), Gaps = 196/1329 (14%)
Query: 36 EVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDD 95
E L + ++E + ++ + + K K KE + + ++ + R+ K +A D
Sbjct: 932 ETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELK--EAARQHRD 989
Query: 96 QVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPP 155
+A + E SSS+ + K +KQ L+ Q++ + D+ ++ ++V+ ++
Sbjct: 990 DLAALQ----EESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQ-----EKLRET 1040
Query: 156 SEAAASKKKPGQKKSKNGSDDQDKKVETLMV---PSKRQEALPLHQETKQESGSGKKKAS 212
E +K+ ++K+ +K+ L++ S RQ+ L ++ QE+ +K+ S
Sbjct: 1041 QEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELS 1100
Query: 213 SKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDL----LKPDQVEGIQKSGT 268
++ + ++ L++ ++S + +++ L K Q++ +S
Sbjct: 1101 AQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTE 1160
Query: 269 KKLKT------ETDKENAEVKFKDFLLSLKTMMFS-----------EDEALCVVDLLKEK 311
+L+ ++ A+ + +L+ + S D A V L ++
Sbjct: 1161 SQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQ 1220
Query: 312 SGVIQ-----DALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEK 366
+G L S + + +H+L + L ++ +D+ ++L + + +
Sbjct: 1221 NGARSLFKRGPLLTALSAEAVASALHKLHQD---LWKTQQTRDVLRDQVQKLEERLTDTE 1277
Query: 367 ERSNVVITRMKD---RIGTLEKEHNVF---QNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
+ V T ++D ++ ++E + + QN + E + Q + E +
Sbjct: 1278 AEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRM 1337
Query: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTG----KLQQEEVQK 476
+ E +L+ A N T Q+E Q+A + Q A + E +T KL+ EEV+
Sbjct: 1338 EAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVES 1397
Query: 477 KNAEQAATQ----LKV---------------QLQEAERRWEEVQSYIR--KRTAEHEAAQ 515
+ A Q LKV L E E E ++ I+ ++ E + A
Sbjct: 1398 ERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAA 1457
Query: 516 QDLQSKFVAKEN-----------EVQSLHSKLTDTLVSKQQLEQRLM----QLMESEQKR 560
+L S + K N E++ S L ++ Q+ EQ+L Q+ E E+ R
Sbjct: 1458 LELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDR 1517
Query: 561 VNKEESLQMQVQDILEQN---EALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIK 617
+ L+ Q+ ++ +++ E+ + Q+Q Q+ ++ EE H + + K IK
Sbjct: 1518 ETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIK 1577
Query: 618 QTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYV 677
+ E ++R LT D++ + L+A+ ++ L + A EL++ Q V
Sbjct: 1578 ELEGQRETQRVALT---HLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKS 1634
Query: 678 KDDKIRLLEEQLQH---EISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQME 734
+ ++I L+ Q +H ++ + +E + ++ + L+ + + ++ E +EQ++
Sbjct: 1635 QREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEED-----LEQIK 1689
Query: 735 KCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFAS 794
++E+ +L T +L++ EE + + SL
Sbjct: 1690 LSLRERGRELTTQRQLMQ------ERAEEGKGPSKAQRGSL------------------- 1724
Query: 795 LVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQ 854
E +K ++ +K+ +++ +E + ++ L+Q+++ L ++G L +Q
Sbjct: 1725 --EHMKLILRDKEKEVECQQE-------HIHELQELKDQLEQQLQGLHRKVGETSLLLSQ 1775
Query: 855 -QLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQE 913
+ I Q+LQ + E + ++++ L+E ++ LA + L+ LQ+E + + +
Sbjct: 1776 REQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEER 1835
Query: 914 VAQHNLKEASSASQ--FEELEIVLKEKENEL-------KRLEAMLKERESDLSSKTQLLQ 964
V KE + A Q E+ + LKE+ EL +RLE L + + ++L
Sbjct: 1836 V-----KEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLG 1890
Query: 965 DVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLK--------VISEREKEISGLWNELD 1016
D++ E++ + + L+QQ +QA L+ V+ ER++E+ L E
Sbjct: 1891 DLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQ 1950
Query: 1017 SLKDAVEHQRKKNNERQQQV----------EAVELEAKEVLKKLFPKVSVPSNLSYGEWL 1066
S + E R + Q+ + E LE E+ + L + S + + +
Sbjct: 1951 SSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSL--EASTATLQASLDAC 2008
Query: 1067 HGFEKKAKECMAGTSG---------SEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAET 1117
++ +E + G E+V+ L+ L + DE +L ++ + L E
Sbjct: 2009 QAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDE-----ELRHQQEREQLLE- 2062
Query: 1118 EGILQKLQRSVEQEENKWKVKVDES-----HKTIKQMQSSFTSSEQELERLR--SENKDI 1170
+ + Q++Q ++ QE+ + +E H++++++Q + EQE+ LR + ++
Sbjct: 2063 KSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNL 2122
Query: 1171 ENLRREREHLEMELEKAEME--RSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHK 1228
E L + ME + +++ E+ L+A L +T + + + Q +A L +
Sbjct: 2123 EALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQ 2182
Query: 1229 AQQSLELIQ 1237
+ S+ +Q
Sbjct: 2183 TKASVSSLQ 2191
Score = 147 bits (370), Expect = 8e-35
Identities = 258/1337 (19%), Positives = 554/1337 (41%), Gaps = 217/1337 (16%)
Query: 38 LAKQKREQKLIPTKTDKKKAEKKK----NKKKEIQNGNLHESDSESVPRDFKLSDALAVE 93
L Q Q+L+ + +K E ++ K+ E + +L S E R L +A ++
Sbjct: 1019 LVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIR 1078
Query: 94 DDQVAPVPLNVVETSSSVRE--------RKKKEKKQKPVL--EEQVIKESDASKIPGK-- 141
+++ + ++ E +E R++ ++K+ L E Q+++E +AS I +
Sbjct: 1079 QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQL 1138
Query: 142 ---------KVEPVPVTKQPTPPS-EAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQ 191
K + + + T EA A++++PG + + + + S Q
Sbjct: 1139 RASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQA--------QAQLASLYSALQ 1190
Query: 192 EALPLHQETKQESGSGKKKASS------KKQKTENVFVDEPLIHATTYIPLMDNADSSPV 245
+AL E++ E G A S + ++F PL+ A L A +S +
Sbjct: 1191 QALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTA-----LSAEAVASAL 1245
Query: 246 VDKREVIDLLKPDQVEGIQKSGTKKLK---TETDKENAEVKFKDFLLSLKTMMFSEDEAL 302
+ DL K Q + + +KL+ T+T+ E ++V + L L+ + E
Sbjct: 1246 HKLHQ--DLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTE--LQDLQRQLSQNQEE- 1300
Query: 303 CVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEM 362
K K Q++L+ S EL + LQ + + + +A ++ + + +
Sbjct: 1301 ------KSKWEGKQNSLE-SELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENL 1353
Query: 363 MTEKERSNVVITRMKDRI---GTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEI 419
+ E + + + G LE++ ++ + + +E + + + Q ++EQ E ++
Sbjct: 1354 TAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKV 1413
Query: 420 AHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNA 479
A K L++ ++ T L ++ E+ LR L +Q E+QK
Sbjct: 1414 AQGKA----LQENLALLTQTLAEREE-EVETLRGQIQELE----------KQREMQKAAL 1458
Query: 480 EQAATQLKVQLQEAERRWEEVQSYIRKRTA-EH-EAAQQDLQSKFVAKENEVQSLHSKLT 537
E + LK + QE + + E++Q + R+ EH A Q+ + K + +++ L
Sbjct: 1459 ELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEK--- 1515
Query: 538 DTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTS 597
D + LE +L++L + +Q E+ + Q+Q Q+
Sbjct: 1516 DRETQRNVLEHQLLELEKKDQ------------------MIESQRGQVQDLKKQLVTLEC 1557
Query: 598 ASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQAL 657
++ EE H + + K IK+ E ++R LT D++ + L+A+ ++ L
Sbjct: 1558 LALELEENHHKMECQQKLIKELEGQRETQRVALTHLT---LDLEERSQELQAQSSQIHDL 1614
Query: 658 ANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH---EISNKMEEFKILNDQNKALKSEV 714
+ A EL++ Q V + ++I L+ Q +H ++ + +E + ++ + L+ +
Sbjct: 1615 ESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQR 1674
Query: 715 QKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSS 774
+ ++ E +EQ++ ++E+ +L T +L++ EE + + S
Sbjct: 1675 TRQTKILEED-----LEQIKLSLRERGRELTTQRQLMQE------RAEEGKGPSKAQRGS 1723
Query: 775 LTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDL 834
L E +K ++ +K+ +++ +E + EL ++ ++ L
Sbjct: 1724 L---------------------EHMKLILRDKEKEVECQQEHIH-ELQELKDQ------L 1755
Query: 835 KQEIKALKEEIGNVQLEKAQ-QLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANT 893
+Q+++ L ++G L +Q + I Q+LQ + E + ++++ L+E ++ LA
Sbjct: 1756 EQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQR 1815
Query: 894 GKWLQDLQEENESLKAHVQEVAQHNLKEASSASQ--FEELEIVLKEKENEL-------KR 944
+ L+ LQ+E + + + V KE + A Q E+ + LKE+ EL +R
Sbjct: 1816 DQELEALQQEQQQAQGQEERV-----KEKADALQGALEQAHMTLKERHGELQDHKEQARR 1870
Query: 945 LEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISER 1004
LE L + + ++L D++ E++ + + L+QQ +QA HE + + +
Sbjct: 1871 LEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQE---HEVETRALQDS 1927
Query: 1005 EKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGE 1064
+ + E D +A+ + + + +++ A +E L K
Sbjct: 1928 WLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAH------------- 1974
Query: 1065 WLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKL 1124
A G E+ H L++A E+ L+ ++ L + ++L
Sbjct: 1975 -------------AALQGKEQ-----HLLEQA-ELSRSLEASTATLQASLDACQAHSRQL 2015
Query: 1125 QRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMEL 1184
+ ++ +E + + + + ++Q+Q + ++EL + + +E +R M
Sbjct: 2016 EEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQ 2075
Query: 1185 EKAEMERSTYVTEVRELK----------AQLNETLTKLR-TEQNERQKVAGDLHKA---- 1229
EK + + E+R L AQ + + +LR T+Q + HK
Sbjct: 2076 EKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPME 2135
Query: 1230 QQSLEL--IQSKIVKAAGDTTVIENSDVSPETESSEK-ETMSVSLNQT---VTQLQQLLQ 1283
+QSL+L ++ ++ + + E E EK + +++SL QT V+ LQ++
Sbjct: 2136 EQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAM 2195
Query: 1284 AVNQQLTKEKEHYQVLE 1300
+ + + Q L+
Sbjct: 2196 FLQASVLERDSEQQRLQ 2212
Score = 144 bits (363), Expect = 5e-34
Identities = 229/1061 (21%), Positives = 459/1061 (43%), Gaps = 132/1061 (12%)
Query: 291 LKTMMFSEDEALCVVDLLKEKSGV-IQDAL--KKSSKGELTTLIHQLQEKDKLLAAVKED 347
L++ +F + V+++ K + V IQ K+ +GE+ L +L + ++ A + D
Sbjct: 769 LESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLEL-DTERSQAEQERD 827
Query: 348 AAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTL-EKEHNVFQNKIHVSYQ----ETQ 402
AAA + Q QE T E+ + +++ EKE + Q ++ + + E
Sbjct: 828 AAARQ--LAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKM 885
Query: 403 QMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNEL 462
+++M+ ++ + +MEA A ++E A+ + E ++ + L L Q L +
Sbjct: 886 ELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADAS 945
Query: 463 TEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTA--EHEAAQ----- 515
+ Q +VQK ++ L+ QLQEA+R +E R A + E++
Sbjct: 946 QQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDK 1005
Query: 516 -------QDLQSKFVAKENE----VQSLHSKLTDT-----------------LVSKQQLE 547
+DL+S+ VA+++ Q + KL +T +S + E
Sbjct: 1006 MDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKE 1065
Query: 548 QRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHK 607
QRL+ L E++ R + +L+ +Q+ + + L AQ++ ++ + A LA+E
Sbjct: 1066 QRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEV-KEKEADFLAQEAQ- 1123
Query: 608 VIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE-----QA 662
+ E+ + TE L R L ++E + +Q L++ +L+ALA E QA
Sbjct: 1124 -LLEELEASHITEQQL---RASLWAQEAKAAQLQ---LRLRSTESQLEALAAEQQPGNQA 1176
Query: 663 AAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVS 722
A +L + ++ + +L + + + DQN A + K L++
Sbjct: 1177 QAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGA--RSLFKRGPLLT 1234
Query: 723 EQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDL 782
+ V + K Q+ + +T + L + QV EE L E S + E+QDL
Sbjct: 1235 ALSAEAVASALHKLHQDLWKTQQTRDVLRD----QVQKLEERLTDTEAEKSQVHTELQDL 1290
Query: 783 KAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALK 842
+ + + S E + + + ++ L++ L + + Q ++ ++A K
Sbjct: 1291 QRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAK 1350
Query: 843 EEIGNVQLEKAQQLSITSKVQ-ELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQ 901
E + Q+E Q + ++ Q +L EE + T ++ L+ K +++ + + Q LQ
Sbjct: 1351 ENL-TAQVEHLQAAVVEARAQASAAGIL---EEDLRTARSALKLKNEEVESERERAQALQ 1406
Query: 902 EENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAML----KERESDLS 957
E+ E LK + Q NL L L E+E E++ L + K+RE +
Sbjct: 1407 EQGE-LKVAQGKALQENL---------ALLTQTLAEREEEVETLRGQIQELEKQREMQKA 1456
Query: 958 SKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPH-----EELLKVISEREKEISGLW 1012
+ L D++ N+ Q EQ+ Q ++ S H +E + ++ + ++I L
Sbjct: 1457 ALELLSLDLKKRNQEVDLQQEQI--QELEKCRSVLEHLPMAVQEREQKLTVQREQIRELE 1514
Query: 1013 NELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKK 1072
+ ++ ++ +EHQ + ++ Q +E+ + +++ K+L
Sbjct: 1515 KDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLV--------------------- 1553
Query: 1073 AKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEE 1132
EC+A E++ HK++ ++ + +LE ++ +A T L +RS E +
Sbjct: 1554 TLECLA-----LELEENHHKMECQQKL--IKELEGQRETQRVALTHLTLDLEERSQELQA 1606
Query: 1133 NKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERS 1192
++ ESH T+ + +QE ++S+ + IE L+R++EHL +LE+ + E
Sbjct: 1607 QSSQIHDLESHSTV--LARELQERDQE---VKSQREQIEELQRQKEHLTQDLERRDQELM 1661
Query: 1193 TYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSL----ELIQSKIVKAAGDTT 1248
++ L+ Q TK+ E E+ K++ L + + L +L+Q + + G +
Sbjct: 1662 LQKERIQVLEDQRTRQ-TKILEEDLEQIKLS--LRERGRELTTQRQLMQERAEEGKGPSK 1718
Query: 1249 VIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQL 1289
S + +KE + + +LQ+L + QQL
Sbjct: 1719 AQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQL 1759
Score = 136 bits (343), Expect = 1e-31
Identities = 223/1003 (22%), Positives = 420/1003 (41%), Gaps = 117/1003 (11%)
Query: 365 EKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQ 424
E+ + R + I L N + ++ + + +K + E + + L Q
Sbjct: 562 EQTEVTAALARAEQSIAELSSSENTLKTEV----ADLRAAAVKLSALNEALALDKVGLNQ 617
Query: 425 ENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAAT 484
+ L + + +++E+ + A N L+ D A K E Q + AE+A
Sbjct: 618 QLLQLEEENQSVCSRMEAAEQAR-NALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGA 676
Query: 485 QLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQS--KFVAKENEVQSLHSKLTDTLV- 541
+L+ L++ + EE+Q + + + EAA L+ + ++ EV + + + LV
Sbjct: 677 ELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVR 736
Query: 542 SKQQLEQRL-------MQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAA 594
K LE RL L E Q + +E L+ + + +QN ++ Q QI
Sbjct: 737 EKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQT 796
Query: 595 QTSA-SVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKD-IQNMNFLLKAEVQ 652
T A V+ E+ + E D + Q E + +L E+E K ++ + EV
Sbjct: 797 VTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVN 856
Query: 653 KL------------QALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEF 700
+L Q LA +A + E EKM+ + +K+ + + Q Q E E
Sbjct: 857 QLREKWEKERSWHQQELA--KALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAES 914
Query: 701 KILNDQNKALKSEVQKLQTLVSEQPN-KDVVEQMEKCIQEKDEKLKTVEELLETGLIQVA 759
+ Q + K V L+TL+ Q D +Q+E+ Q D K++ ++E TG++Q
Sbjct: 915 ALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQ--DMKVQKLKEQETTGILQTQ 972
Query: 760 TKE-------------EELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEK 806
+E ++L A++ E+SSL ++ DL+ + VE+LK + +
Sbjct: 973 LQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQ----------VEDLKSQLVAQ 1022
Query: 807 DGKIKSVEELLEAELLKVANKEKTVQDLKQE-----IKALKEEIGNVQLEKA-----QQL 856
D + VE+ ++ +L + + ++L++E + +++E + L++A Q+L
Sbjct: 1023 DDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQEL 1082
Query: 857 S-ITSKVQELQNLLKGKEEQMNTMKAVLEEKEKD-LANTGKWLQDL-------QEENESL 907
S + +QE Q K QM ++ ++EKE D LA + L++L Q+ SL
Sbjct: 1083 SALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASL 1142
Query: 908 KAHVQEVAQHNLKEASSASQFEELEIVLK-----EKENELKRLEAMLKER-ESDLSSKTQ 961
A + AQ L+ S+ SQ E L + + + +L L + L++ S S+ +
Sbjct: 1143 WAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPE 1202
Query: 962 LLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDA 1021
L ++ + +Q ++ + V S K LW + +D
Sbjct: 1203 LSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLW-KTQQTRDV 1261
Query: 1022 VEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTS 1081
+ Q +K ER EA + + L+ L ++S E+K+K G
Sbjct: 1262 LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLS-----------QNQEEKSK--WEGKQ 1308
Query: 1082 GSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDE 1141
S LE +L E E LQ + + E +G + LQ + E +V+
Sbjct: 1309 NS-----LESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKE----NLTAQVEH 1359
Query: 1142 SHKTIKQMQSSFTSS---EQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEV 1198
+ + ++ +++ E++L RS L+ + E +E E E+A+ + +V
Sbjct: 1360 LQAAVVEARAQASAAGILEEDLRTARSA------LKLKNEEVESERERAQALQEQGELKV 1413
Query: 1199 RELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPE 1258
+ KA L E L L ER++ L Q LE Q ++ KAA + ++ + E
Sbjct: 1414 AQGKA-LQENLALLTQTLAEREEEVETLRGQIQELEK-QREMQKAALELLSLDLKKRNQE 1471
Query: 1259 TESSEKETMSVSLNQTVTQ-LQQLLQAVNQQLTKEKEHYQVLE 1300
+ +++ + ++V + L +Q Q+LT ++E + LE
Sbjct: 1472 VDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELE 1514
Score = 128 bits (321), Expect = 4e-29
Identities = 192/973 (19%), Positives = 420/973 (43%), Gaps = 128/973 (13%)
Query: 248 KREVIDLLKPDQVEGIQKSGTKKLKT----------ETDKENAEVKFKDFLLS-LKTMMF 296
+ ++++L K DQ+ Q+ + LK E ++ + +++ + L+ L+
Sbjct: 1525 EHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRE 1584
Query: 297 SEDEALCVVDL-LKEKSGVIQDALKK--SSKGELTTLIHQLQEKDKLLAAVKEDAAATKD 353
++ AL + L L+E+S +Q + + T L +LQE+D+ + + +E +
Sbjct: 1585 TQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQR 1644
Query: 354 RCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVRE 413
+ + LTQ++ ER + + K+RI LE + ++T+ ++ +Q++
Sbjct: 1645 QKEHLTQDL----ERRDQELMLQKERIQVLEDQRT----------RQTKILEEDLEQIKL 1690
Query: 414 QMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEE 473
+ L + ++++ E K ++ + ++ +L+ EK + QQE
Sbjct: 1691 SLRERGRELTTQRQLMQERAE------EGKGPSKAQRGSLEHMKLILRDKEKEVECQQEH 1744
Query: 474 VQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLH 533
+ + ++ QL+ QLQ R+ E + +R E QQ LQ E + QSL
Sbjct: 1745 IHE--LQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQ 1802
Query: 534 SKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIA 593
S+L + + Q +Q L L + +Q+ +EE ++ E+ +AL+ ++Q H +
Sbjct: 1803 SQLDEAQRALAQRDQELEALQQEQQQAQGQEERVK-------EKADALQGALEQAHMTL- 1854
Query: 594 AQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQK 653
+E H + + +Q ++ E+ LA E R+ + EE L D++ + + + +
Sbjct: 1855 ---------KERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAES---REQEKA 1902
Query: 654 LQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSE 713
L AL + A A E E +++ + + + ++ E+ E + Q +A ++
Sbjct: 1903 LLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARAR 1962
Query: 714 VQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENS 773
+ LQ + + + +Q K++ L EL + AT + L+A + +
Sbjct: 1963 AEALQ---------EALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSR 2013
Query: 774 SLTKEVQDLKAKQNDQ-VSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQ 832
L + ++ + + DQ + + V++L++ + ++D +++ +E +LL+ + ++ +
Sbjct: 2014 QLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQE--REQLLEKSLAQRVQE 2071
Query: 833 DLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLAN 892
++ QE K+ +G + E+ + + V+ELQ L KE++ +LE
Sbjct: 2072 NMIQE----KQNLGQ-EREEEEIRGLHQSVRELQLTLAQKEQE------ILE-------- 2112
Query: 893 TGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKER 952
L++ Q+ N E H+ K + Q +L+ + + EL+RL+A L++
Sbjct: 2113 ----LRETQQRNN------LEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQT 2162
Query: 953 ESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLW 1012
E+ + QD+ K+ + L Q+ + F L + ER+ E L
Sbjct: 2163 EAREIEWREKAQDLALSLAQTKASVSSL-----QEVAMF-----LQASVLERDSEQQRLQ 2212
Query: 1013 NELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKK 1072
+EL+ + A+E +R + EL ++ + GE +
Sbjct: 2213 DELELTRRALEKERLHS---PGATSTAELGSRG-----------EQGVQLGEVSGVEAEP 2258
Query: 1073 AKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEE 1132
+ + M S + ++ L+ + + + LQ + +S L + E +KL+R +
Sbjct: 2259 SPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAA 2318
Query: 1133 NKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERS 1192
+++ K SS T + ++ S+ K + L++E L+ +L ++
Sbjct: 2319 QAGSLEIS------KATASSPTQQDGRGQK-NSDAKCVAELQKEVVLLQAQLTLERKQKQ 2371
Query: 1193 TYVTEVRELKAQL 1205
Y+T + +L
Sbjct: 2372 DYITRSAQTSREL 2384
Score = 125 bits (315), Expect = 2e-28
Identities = 206/953 (21%), Positives = 428/953 (44%), Gaps = 122/953 (12%)
Query: 335 QEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNV----VITRMKDRIGTLEKEHNVF 390
QE +L + + A +DR +L+ ++T+ ++ N +I +++ + LE H
Sbjct: 265 QELIQLKSQGDLEKAELQDRVTELSA-LLTQSQKQNEDYEKMIKALRETVEILETNHTEL 323
Query: 391 QNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK 450
+ Q+ ++ QQV + + + +++ + I + + + +L+S ++ +
Sbjct: 324 MEHEASLSRNAQEEKLSLQQVIKDITQVM--VEEGDNIAQGSGHENSLELDSSIFSQFDY 381
Query: 451 LRQDYA-RLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTA 509
D A LV + + + Q+ Q+ Q A L LQ+ +WEE +R+R
Sbjct: 382 QDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNL---LQQQHDQWEEEGKALRQRLQ 438
Query: 510 EHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQ---KRVNKEES 566
+ + L + V + EV SL + ++++L Q+L +++E E +RVN E
Sbjct: 439 KLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQL-EVLEQEAWRLRRVNVELQ 497
Query: 567 LQ---MQVQDILEQNEALKA-----QIQQFHSQIAAQTSASV-----LAEELHKVIAEKD 613
LQ Q Q +Q E A ++Q+ + A+ S S+ L E L E +
Sbjct: 498 LQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGE 557
Query: 614 -KQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAH------ 666
+ +QTE + A L E+ + ++ + LK EV L+A A + +A
Sbjct: 558 LLRQEQTEVTAA-----LARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDK 612
Query: 667 --------ELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQ 718
+LE+ QSV + + LQ +++ + + L ++N L++++QK +
Sbjct: 613 VGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAE 672
Query: 719 TLVSE--QPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQV---ATKEEELNAIRT-EN 772
+E +D+ E+ E+ IQ+K + + +E T L Q+ A ++EE+ A E
Sbjct: 673 EAGAELQADLRDIQEEKEE-IQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEK 731
Query: 773 SSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQ 832
+L +E L+ + VE ++ + E+ + S +ELLE+ L + + ++
Sbjct: 732 EALVREKAALEVR-------LQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIE 784
Query: 833 DLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLAN 892
K +++ VQ++ ++T + +Q ++ + +++T ++ E+ E+D A
Sbjct: 785 VTKGQLE--------VQIQ-----TVTQAKEVIQGEVRCLKLELDTERSQAEQ-ERDAA- 829
Query: 893 TGKWLQDLQEENESL-----KAHVQEVAQHNLK-EASSASQFEELEIVLKEKENELKRLE 946
+ L ++E ++ AH +EV Q K E + +EL L+ E E LE
Sbjct: 830 -ARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELE 888
Query: 947 AMLKERESDLSSKTQLLQD--VQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISER 1004
LKE+++++ + ++ Q E+ L + Q+E K++ LL+ + +
Sbjct: 889 MRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKER-----------VSLLETLLQT 937
Query: 1005 EKEISGLWNELDSLKDAVEHQRKKNNER----QQQVEAVELEAKEVLKKLFPKVSVPSNL 1060
+KE++ +L+ L+ ++ Q+ K E Q Q++ + E KE ++
Sbjct: 938 QKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQ----------- 986
Query: 1061 SYGEWLHGFEKKAKECMAGTSG-SEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEG 1119
+ + L ++++ + ++V+ L+ +L D+ L++ E ++ L ET+
Sbjct: 987 -HRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQE---KLRETQE 1042
Query: 1120 ILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREH 1179
++Q+ +E+E+ + + E + + +Q + + +QEL LR +D++ + E++
Sbjct: 1043 -YNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALR---QDMQEAQGEQKE 1098
Query: 1180 LEMELEKAEMERSTYVTEVRELKAQLNETLTKLR-TEQNERQKVAGDLHKAQQ 1231
L ++E E + +AQL E L TEQ R + KA Q
Sbjct: 1099 LSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQ 1151
Score = 98.2 bits (243), Expect = 5e-20
Identities = 214/1042 (20%), Positives = 431/1042 (41%), Gaps = 146/1042 (14%)
Query: 298 EDEALCVVDLLKEKSGVIQDALKKSSKGEL--TTLIHQLQEKDKLLAAVKEDAAATKDRC 355
E++ L + + E LK S + + TL+ +LQ K + C
Sbjct: 21 EEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAK----------VLQYRSWC 70
Query: 356 KQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQM 415
++L + + E + I + + + +E N+ +++ V +E QQ +V Q+
Sbjct: 71 QELEKRL----EATGGPIPQRWENV----EEPNL--DELLVRLEEEQQRCESLAEVNTQL 120
Query: 416 EAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQ 475
+ N LR+ ++ KL D++R +EL K + Q E+
Sbjct: 121 RLHMEKADVVNKALRE---------------DVEKLTVDWSRARDELMRKESQWQMEQEF 165
Query: 476 KKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSK 535
K LK + W EV ++ R A +DL E+++ H +
Sbjct: 166 FKG------YLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLM--------ELKAEHVR 211
Query: 536 LTDTLVSK-QQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAA 594
L+ +L++ +L + R++ E Q+ + L A+ Q+ +
Sbjct: 212 LSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLL---------LLAKTQELEKE--- 259
Query: 595 QTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKL 654
A ++EL ++ ++ D + + +D + LT +++ +D + M L+ V+ L
Sbjct: 260 ---AHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEIL 316
Query: 655 QALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEV 714
+ N HE + + +++K+ L +Q+ +I+ M E Q ++ +
Sbjct: 317 ET--NHTELMEHEASLSRNA---QEEKLSL--QQVIKDITQVMVEEGDNIAQGSGHENSL 369
Query: 715 QKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSS 774
+ ++ S+ +D + + + + V++L + Q+A +E +N ++ ++
Sbjct: 370 ELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQ----QLAGCQEAVNLLQQQHDQ 425
Query: 775 LTKEVQDLKAKQNDQVSFASLVEELKKVIHEKD----------GKIKSVEELLEAELLKV 824
+E + L+ + L+K+ E+D G++ S+ + E ELL+
Sbjct: 426 WEEEGKALR-------------QRLQKLTGERDTLAGQTVDLQGEVDSLSK--ERELLQK 470
Query: 825 ANKE--KTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAV 882
A +E + ++ L+QE L+ +QL+ + QE +L + E++ M
Sbjct: 471 AREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMG 530
Query: 883 LEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENEL 942
LE K+ + + L L+E ES + + Q + ++ ++ E+ L EN L
Sbjct: 531 LEAKQSESLSE---LITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTL 587
Query: 943 KRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVI- 1001
K A L+ LS+ + L D+ L Q+ QL+++N S E+ +
Sbjct: 588 KTEVADLRAAAVKLSALNEAL--ALDKVGL-NQQLLQLEEENQSVCSRMEAAEQARNALQ 644
Query: 1002 ---SEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFP-KVSVP 1057
+E EK LW + L+ ++ + E Q + ++ E +E+ KKL +
Sbjct: 645 VDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQE 704
Query: 1058 SNLSYGEWLHGFEKKAKECMAGTSGSEEVKV-----LEHKLK--EADEMHTLLQLECEKY 1110
+ + E LH K+ +E +A +E V LE +L+ E D QL+
Sbjct: 705 AATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSS 764
Query: 1111 KSVLAETEGILQKLQRSV-EQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKD 1169
L E+ + Q SV E + + +V++ + + +Q + EL+ RS+ +
Sbjct: 765 AKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAE- 823
Query: 1170 IENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTE-QNERQKVAGDLHK 1228
+ER+ +L +AE E T + + KA + + +LR + + ER +L K
Sbjct: 824 -----QERDAAARQLAQAEQEGKT---ALEQQKAAHEKEVNQLREKWEKERSWHQQELAK 875
Query: 1229 AQQSLELIQSKI-VKAAGDTTVIENSDVSPETESSEKETM-----------SVSLNQTVT 1276
A +SLE + ++ ++ T +E E E ++ E+ VSL +T+
Sbjct: 876 ALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLL 935
Query: 1277 QLQQLLQAVNQQLTKEKEHYQV 1298
Q Q+ L +QQL + ++ +V
Sbjct: 936 QTQKELADASQQLERLRQDMKV 957
Score = 72.8 bits (177), Expect = 2e-12
Identities = 157/765 (20%), Positives = 302/765 (39%), Gaps = 121/765 (15%)
Query: 636 ELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSV---------YVKDDKIRLLE 686
+LK+ Q V+KLQA + + ELEK ++ V++ + L
Sbjct: 41 KLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDELL 100
Query: 687 EQLQHEISNKMEEFKILNDQ-----------NKALKSEVQKLQTLVSEQPNKDVVEQMEK 735
+L+ E + E +N Q NKAL+ +V+KL V +D + + E
Sbjct: 101 VRLEEE-QQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLT--VDWSRARDELMRKES 157
Query: 736 CIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLT-KEVQDLKAKQNDQVSFAS 794
Q + E K + L+ + + E S T +++ +LKA ++ ++S +
Sbjct: 158 QWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKA-EHVRLSGSL 216
Query: 795 LVEELKKVIHEKD------GKIKSVEEL-LEAELLKVANKEKTVQDLKQEIKALKEEIGN 847
L L+ + + G++ E L L K EK + QE+ LK +
Sbjct: 217 LTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQ--- 273
Query: 848 VQLEKAQQLSITSKVQELQNLL----KGKEEQMNTMKAVLEEKEKDLANTGKWLQ----- 898
LEKA+ + +V EL LL K E+ +KA+ E E N + ++
Sbjct: 274 GDLEKAE---LQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASL 330
Query: 899 --DLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKER---- 952
+ QEE SL+ ++++ Q ++E + +Q E L+ + + + ++
Sbjct: 331 SRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTL 390
Query: 953 -ESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQ-QASSFPPHEELLKVISEREK---E 1007
S L+ + Q +QD++ + + + L+QQ+ Q + + L K+ ER+ +
Sbjct: 391 VRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQ 450
Query: 1008 ISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYG---- 1063
L E+DSL E +K E +QQ+E +E EA L+++ ++ + + + G
Sbjct: 451 TVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWR-LRRVNVELQLQGDSAQGQKEE 509
Query: 1064 ----------------EWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLEC 1107
E L G E K E ++ E+ L L+ + LL+ E
Sbjct: 510 QQEELHLAVRERERLQEMLMGLEAKQSESLS------ELITLREALESSHLEGELLRQEQ 563
Query: 1108 EKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQS-------SFTSSEQEL 1160
+ + LA E + +L S EN K +V + ++ + Q+L
Sbjct: 564 TEVTAALARAEQSIAELSSS----ENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQL 619
Query: 1161 ERLRSENKDI-------------------------ENLRREREHLEMELEKAEMERSTYV 1195
+L EN+ + E L + HLE +L+KAE +
Sbjct: 620 LQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQ 679
Query: 1196 TEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDV 1255
++R+++ + E KL +++++ L + Q + + + +A + +
Sbjct: 680 ADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKA 739
Query: 1256 SPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
+ E E L + + L + + L + ++ V+E
Sbjct: 740 ALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIE 784
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 149 bits (377), Expect = 1e-35
Identities = 238/1163 (20%), Positives = 485/1163 (41%), Gaps = 168/1163 (14%)
Query: 180 KVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDN 239
K++ L+ ++ ++ + +E Q++ K+ +K+++ E V L+ + L
Sbjct: 836 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVT--LVQEKNDLQLQVQ 893
Query: 240 ADSSPVVDKREVID-LLKPD-QVEGIQKSGTKKLKTETDKENAEV-----KFKDFLLSLK 292
A+S ++D E D L+K Q+E K T++ + E ++ NAE+ K +D LK
Sbjct: 894 AESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDE-EEINAELTAKKRKLEDECSELK 952
Query: 293 TMMFSEDEALCVVD------------LLKEKSGVIQDALKKSSKGELTTLIHQ-----LQ 335
+ + L V+ L +E SG+ + K + + + HQ LQ
Sbjct: 953 KDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQ 1012
Query: 336 -EKDKLLAAVK---------EDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEK 385
E+DK+ + K ED ++ ++ K+L ++ K + + ++ I LE
Sbjct: 1013 AEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLEN 1072
Query: 386 EHNVFQNKIHVSYQETQQMQMK----------FQQVREQMEAEIAHLKQENGILRDAVSN 435
+ ++ E Q+Q K FQ+ ++++A I L++E
Sbjct: 1073 DKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEI--------- 1123
Query: 436 TTNQLESKQSAELNKLRQDYARLVNELTEK---TGKLQQEEVQ-KKNAEQAATQLKVQLQ 491
+ E A+ K R DYAR + EL+E+ G + +++ K E +L+ L+
Sbjct: 1124 ---EAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLE 1180
Query: 492 EAERRWEEVQSYIRKRTAEHEA-----------AQQDLQSKFVAKENEVQSLHSKLTDTL 540
EA + E + + +RK+ A+ A +Q L+ + + E+ L S +
Sbjct: 1181 EATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVS 1240
Query: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQ------IAA 594
SK LE+ L + + K E +Q + ++ Q L+ + + Q I +
Sbjct: 1241 KSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVS 1300
Query: 595 QTSASVLA-----EELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKA 649
Q S S A EEL + + E++K +L S R E+ ++ Q KA
Sbjct: 1301 QLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEG----KA 1356
Query: 650 EVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKA 709
E+Q+ + AN + A K + + +++ +++L + + E+ + +N + +
Sbjct: 1357 ELQRALSKANSEVAQWRT--KYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCAS 1414
Query: 710 LKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIR 769
L+ Q+LQ V + VE+ D+K + +++L + + EL A
Sbjct: 1415 LEKTKQRLQGEVEDLMVD--VERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASL 1472
Query: 770 TENSSLTKEVQDLK---------------AKQNDQVSFASLVEELK---KVIHEKDGKIK 811
E+ SL+ E+ LK +N + A L E++ K IHE + K
Sbjct: 1473 KESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRK 1532
Query: 812 SVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKG 871
+E LE +++A +E +E K L+ ++ Q++ I K +E++ L +
Sbjct: 1533 QIE--LEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRN 1590
Query: 872 KEEQMNTMKAVLEEKEK---DLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSAS-Q 927
+ + TM++ L+ + + + K ++ E E +H A LK S Q
Sbjct: 1591 YQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQ 1650
Query: 928 FEELEIVLKEK---ENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQN 984
++ ++ L + + +LK A+++ R + L ++ + L+ ++ + + EQ +
Sbjct: 1651 LKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDS 1710
Query: 985 YQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAK 1044
++ H + +I ++K + L ++DA R + ++ + + A+
Sbjct: 1711 NERVQLL--HTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAE 1768
Query: 1045 EVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQ 1104
E+ K+ + E+ K + VK L+H+L EA+ Q
Sbjct: 1769 ELKKEQDTSAHL-------------ERMKKNL------EQTVKDLQHRLDEAE------Q 1803
Query: 1105 LECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLR 1164
L + K + + E +++L+ +E E+ K V K ++++ SE++
Sbjct: 1804 LALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEED----- 1858
Query: 1165 SENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAG 1224
R+ L+ ++K +++ +Y + E Q N LTK R Q+E
Sbjct: 1859 ---------RKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHE------ 1903
Query: 1225 DLHKAQQSLELIQSKIVKAAGDT 1247
L +A++ ++ +S++ K T
Sbjct: 1904 -LEEAEERADIAESQVNKLRAKT 1925
Score = 119 bits (298), Expect = 2e-26
Identities = 232/1187 (19%), Positives = 499/1187 (42%), Gaps = 122/1187 (10%)
Query: 23 LFFWL--FMKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESV 80
LFF + +K ++ +A K E + TK + K+E K+ + +E + E + +
Sbjct: 833 LFFKIKPLLKSAETEKEMATMKEEFQ--KTKDELAKSEAKRKELEEKLVTLVQEKNDLQL 890
Query: 81 PRDFKLSDALAVED--DQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKI 138
+ + L E+ DQ+ + V ER + E++ L + K D
Sbjct: 891 QVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 950
Query: 139 PGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKV--ETLMVPSKRQEALPL 196
K ++ + +T + A K + +G D+ K+ E + Q+AL
Sbjct: 951 LKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDD 1010
Query: 197 HQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLK 256
Q + + S K S +Q+ E++ +SS +K+ +DL +
Sbjct: 1011 LQAEEDKVNSLNKTKSKLEQQVEDL-------------------ESSLEQEKKLRVDLER 1051
Query: 257 PDQ-VEGIQKSGTKK-LKTETDKENAE--VKFKDFLLSLKTMMFSEDEALCVV--DLLKE 310
+ +EG K + L E DK+ + +K KDF +++ L + +KE
Sbjct: 1052 NKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKE 1111
Query: 311 KSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSN 370
I++ L++ + E T +++ ++E + ++ + ++ K+R
Sbjct: 1112 LQARIEE-LEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREA 1170
Query: 371 VVITRMKD-RIGTLEKEHNV--FQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENG 427
+ +D TL+ E V + K S E + Q+V++++E E + K E
Sbjct: 1171 EFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEID 1230
Query: 428 ILR---DAVSNTTNQLES------KQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKN 478
L ++VS + LE Q +E ++ R ++ELT + +LQ E
Sbjct: 1231 DLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTE------ 1284
Query: 479 AEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTD 538
A +L QL+E E ++ + T + E ++ L+ + AK +L S D
Sbjct: 1285 ----AGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHD 1340
Query: 539 TLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSA 598
+ ++Q E+ E+ + ++Q L + +++ Q+ ++ +T A
Sbjct: 1341 CDLLREQYEE---------------EQEGKAELQRALSK---ANSEVAQWRTKY--ETDA 1380
Query: 599 SVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALA 658
EEL + + ++++ +E+ + + + S E+ + +Q L +V++ +LA
Sbjct: 1381 IQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLA 1440
Query: 659 NEQAAAAHELEKMQQSVYVKDDKIRL-LEEQLQHEISNKMEEFKILNDQNKAL-KSEVQK 716
+K+ K ++ + LE L+ S E FK+ N +AL + E K
Sbjct: 1441 AALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVK 1500
Query: 717 LQTLVSEQPNKDVVEQME---KCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENS 773
+ EQ D+ EQ+ K I E ++ K +E LE IQ+A +E E E
Sbjct: 1501 RENKNLEQEIADLTEQIAENGKTIHELEKSRKQIE--LEKADIQLALEEAEAALEHEEAK 1558
Query: 774 SLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQD 833
L +++ + K A EE++++ +++++ L+AE V ++ + ++
Sbjct: 1559 ILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAE---VRSRNEAIR- 1614
Query: 834 LKQEIKALKEEIGNVQLEKA--QQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLA 891
LK++++ EI +QL A Q ++ +Q LK + ++ E+ ++ LA
Sbjct: 1615 LKKKMEGDLNEI-EIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLA 1673
Query: 892 NTGKWLQDLQEENESLKAHVQEVAQ-HNLKEASSASQFEELEIVLKEKENEL---KRLEA 947
+ LQ E E L+A +++ + L E E ++++ + + + K+LE
Sbjct: 1674 IVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLET 1733
Query: 948 MLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKE 1007
L + +S++ ++ ++ +++ K + + ++ ++ + E + K + + K+
Sbjct: 1734 DLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKD 1793
Query: 1008 ISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLH 1067
+ +E + L A++ +K+ + + ++ +E E + KK N + L
Sbjct: 1794 LQHRLDEAEQL--ALKGGKKQIQKLETRIRELEFELEGEQKK---------NTESVKGLR 1842
Query: 1068 GFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRS 1127
+E++ KE T SEE + +L++ + LQ++ + YK E
Sbjct: 1843 KYERRVKEL---TYQSEEDRKNVLRLQDLVDK---LQVKVKSYKRQAEE----------- 1885
Query: 1128 VEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLR 1174
+++ N K ++ +++ + +E ++ +LR++ +D + R
Sbjct: 1886 ADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSR 1932
Score = 99.0 bits (245), Expect = 3e-20
Identities = 121/581 (20%), Positives = 250/581 (43%), Gaps = 47/581 (8%)
Query: 720 LVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEV 779
L S + K++ E+ + KDE K+ + E EE+L + E + L +V
Sbjct: 841 LKSAETEKEMATMKEEFQKTKDELAKSEAKRKEL--------EEKLVTLVQEKNDLQLQV 892
Query: 780 QDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIK 839
Q A+ + + ++L K + + KIK V E E E A + L+ E
Sbjct: 893 Q---AESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECS 949
Query: 840 ALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQD 899
LK++I +++L A KV++ ++ + K + + + L+E L K LQ+
Sbjct: 950 ELKKDIDDLELTLA-------KVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQE 1002
Query: 900 L-QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSS 958
Q+ + L+A +V N ++ Q E+LE L++++ LE ++ E DL
Sbjct: 1003 AHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKL 1062
Query: 959 KTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSL 1018
+ + D++++ + ++++ K Y Q S E+ L + + +K+I L ++ L
Sbjct: 1063 AQESILDLENDKQQLDERLKK-KDFEYCQLQSKVEDEQTLGL--QFQKKIKELQARIEEL 1119
Query: 1019 KDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPS-NLSYGEWLHGFEKKAKECM 1077
++ +E +R + ++Q E +E+ ++L V S + + K + +
Sbjct: 1120 EEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDL 1179
Query: 1078 AGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKV 1137
+ E V + K AD + + L E LQ++++ +E+E++++K+
Sbjct: 1180 EEATLQHEAMVAALRKKHADSV------------AELGEQIDNLQRVKQKLEKEKSEFKL 1227
Query: 1138 KVDESHKTIKQMQSSFTSSEQELERL-RSENKDIENLRREREHLEMELEKAEMERSTYVT 1196
++D+ + S + S+ LE++ R+ + R + E ++ L + ++S T
Sbjct: 1228 EIDD----LSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQT 1283
Query: 1197 EVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVS 1256
E EL QL E + + +Q + ++ LE ++K A D
Sbjct: 1284 EAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLE-EENKAKNALAHALQSSRHDCD 1342
Query: 1257 PETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1297
E E+E + +LQ+ L N ++ + + Y+
Sbjct: 1343 LLREQYEEE------QEGKAELQRALSKANSEVAQWRTKYE 1377
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 149 bits (377), Expect = 1e-35
Identities = 214/1094 (19%), Positives = 482/1094 (44%), Gaps = 165/1094 (15%)
Query: 308 LKEKSGVIQDALKKSS--KGELTT-LIHQLQEKDKL---LAAVKEDAAATKDRCKQLTQ- 360
+KE+ G I++ L+KS + EL ++ LQEK+ L + A +++ ++RC QL +
Sbjct: 854 MKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKN 913
Query: 361 ------------EMMTEKERSNVVIT----RMKDRIGTLEKEHNVFQNKIHVSYQETQQM 404
E + ++E N +T +++D L+K+ + + + +E
Sbjct: 914 KIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 973
Query: 405 QMKFQQVREQM---EAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE 461
+ K + + E+M + IA L +E L++A + L+ ++ ++N L + +L +
Sbjct: 974 ENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEED-KVNSLSKSKVKLEQQ 1032
Query: 462 LTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSK 521
+ + G L+QE+ ++++ L+ A+R+ E ++ + E + L+ K
Sbjct: 1033 VDDLEGSLEQEK-----------KVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEK 1081
Query: 522 FVAKENEVQSLHSKLTDTLVSKQQLEQRLMQ---LMESEQKRVNKEESLQMQVQ----DI 574
KE ++ +SK+ D V QL+++L + +E ++ + E + + +V+ D+
Sbjct: 1082 LKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDL 1141
Query: 575 LEQNEALKAQIQQFHSQIAAQTSASVLAE-ELHKVIAEKDKQIKQTEDSLASER----DR 629
+ E + ++++ + Q + E E K+ + ++ Q E + A+ R D
Sbjct: 1142 SRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADS 1201
Query: 630 LTSKEEELKDIQNMNFLL-------KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKI 682
+ E++ ++Q + L K E+ + + + A LEK+ +++ + ++
Sbjct: 1202 VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEY 1261
Query: 683 RLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSE--QPNKDVVEQMEKCIQEK 740
R+ E+ Q +++ + L +N L ++++ + L+S+ + +QME ++
Sbjct: 1262 RVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQL 1321
Query: 741 DEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTK-EVQDLKAKQNDQVS-------- 791
+E+ K L +Q A + +L + E + K E+Q + +K N +V+
Sbjct: 1322 EEEGKAKNALAHA--LQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYET 1379
Query: 792 -FASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEI----- 845
EEL++ + +++ EE +EA K ++ EKT L+ EI+ L ++
Sbjct: 1380 DAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNA 1439
Query: 846 GNVQLEKAQQ------LSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQD 899
L+K Q+ K +E Q+ L+ +++ ++ L + + + + L+
Sbjct: 1440 AAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLET 1499
Query: 900 LQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSK 959
+ EN++L+ + ++ + + ELE V K+ E E L++ L+E E+ L +
Sbjct: 1500 FKRENKNLQEEISDLTE---QLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHE 1556
Query: 960 TQLLQDVQDENKLFKSQIEQL---KQQNYQQA------------SSFPPHEELLKVISER 1004
+ Q E K++IE+ K + +QA +S +
Sbjct: 1557 EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRV 1616
Query: 1005 EKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGE 1064
+K++ G +L+ ++ + H + E Q+QV++++ K+ +L V +L
Sbjct: 1617 KKKMEG---DLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDL---- 1669
Query: 1065 WLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKL 1124
E + ++E + + LLQ E E+ ++V+ +TE +
Sbjct: 1670 ------------------KENIAIVERR-------NNLLQAELEELRAVVEQTE----RS 1700
Query: 1125 QRSVEQE--ENKWKVKVDESHKTI-----KQMQSSFTSSEQELERLRSENKDI-ENLRRE 1176
++ EQE E +V++ S T K+M+S T + E+E E ++ E ++
Sbjct: 1701 RKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKA 1760
Query: 1177 REHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELI 1236
M E+ + E+ T + +K + +T+ L+ +E +++A L ++ L+ +
Sbjct: 1761 ITDAAMMAEELKKEQDT-SAHLERMKKNMEQTIKDLQHRLDEAEQIA--LKGGKKQLQKL 1817
Query: 1237 QSKIVKAAGDTTVIEN----------------SDVSPETESSEKETMSVSLNQTVTQLQQ 1280
++++ + G+ + +++ +TE +K + L V +LQ
Sbjct: 1818 EARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLL--RLQDLVDKLQL 1875
Query: 1281 LLQAVNQQLTKEKE 1294
++A +Q + +E
Sbjct: 1876 KVKAYKRQAEEAEE 1889
Score = 118 bits (296), Expect = 3e-26
Identities = 204/989 (20%), Positives = 426/989 (43%), Gaps = 102/989 (10%)
Query: 35 DEVLAKQKREQKLIP-----------TKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRD 83
DE++AK +E+K + + DK + K K E Q +L S +
Sbjct: 988 DEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVR 1047
Query: 84 FKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKV 143
L A + + ++++ + + ++K KK++ + +Q K D + +
Sbjct: 1048 MDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQ 1107
Query: 144 EPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQE 203
+ + + E ++ + K + D +++E + S+R E + E
Sbjct: 1108 KKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEI---SERLEEAGGATSVQIE 1164
Query: 204 SGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMD-NADSSPVVDKREVIDLLKPDQVEG 262
KK ++ QK + L H T L +ADS V + E ID L+ + +
Sbjct: 1165 MN---KKREAEFQKMRRDLEEATLQHEATAAALRKKHADS--VAELGEQIDNLQRVKQKL 1219
Query: 263 IQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKS 322
++ KL+ + N E K K ED+A L+E + D +
Sbjct: 1220 EKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQR 1279
Query: 323 SK--GELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRI 380
+K E L QL+EK+ L++ + + + + L +++ E + N + ++
Sbjct: 1280 AKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSA- 1338
Query: 381 GTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQL 440
H+ + + Y+E + + + Q+V + +E+A + + DA+ T
Sbjct: 1339 -----RHDC--DLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYET--DAIQRTEELE 1389
Query: 441 ESKQSAELNKLRQDYARLVNELTEKTGKLQQE-------------EVQKKNAEQAATQLK 487
E+K+ +L + QD V + K L++ +V++ NA AA K
Sbjct: 1390 EAKK--KLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKK 1447
Query: 488 VQ-----LQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVS 542
+ L E ++++EE QS + E + +L A E ++ L + +
Sbjct: 1448 QRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNL 1507
Query: 543 KQQLEQRLMQLMESEQKRVNKEESLQMQVQ-DILEQNEALK-AQIQQFHSQ---IAAQTS 597
++++ QL E K V++ E ++ Q++ + LE AL+ A+ H + + AQ
Sbjct: 1508 QEEISDLTEQLGEGG-KNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLE 1566
Query: 598 ASVLAEELHKVIAEKDKQIKQTE-------DSLASERDRLT-SKEEELKDIQNMNFLLKA 649
+ + E+ + +AEKD++++Q + DSL + D T S+ E L+ + M L
Sbjct: 1567 FNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLN- 1625
Query: 650 EVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKA 709
E++ + AN AA A + K QS+ +KD +I+L + ++ + E I+ +N
Sbjct: 1626 EMEIQLSHANRMAAEAQKQVKSLQSL-LKDTQIQLDDAVRAND--DLKENIAIVERRNNL 1682
Query: 710 LKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIR 769
L++E+++L+ +V + + + E + E E+++ + + + Q E +L ++
Sbjct: 1683 LQAELEELRAVVEQTERSRKLAEQE--LIETSERVQLLHSQNTSLINQKKKMESDLTQLQ 1740
Query: 770 TENSSLTKEVQDLKAKQNDQVSFASLV-EELKK----------VIHEKDGKIKSVEELL- 817
+E +E ++ + K ++ A+++ EELKK + + IK ++ L
Sbjct: 1741 SEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLD 1800
Query: 818 EAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMN 877
EAE + + +K +Q L+ ++ L+ E+ Q A+ + KG +
Sbjct: 1801 EAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESV-------------KGMRKSER 1847
Query: 878 TMKAVLEEKEKDLANTGKWLQDLQEENE-SLKAHVQEVAQHNLKEASSASQFEELEIVLK 936
+K + + E+D N + LQDL ++ + +KA+ ++ + + ++ S+F +++ L
Sbjct: 1848 RIKELTYQTEEDKKNLLR-LQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELD 1906
Query: 937 EKENELKRLEAM---LKERESDLSSKTQL 962
E E E+ L+ + D+ +K ++
Sbjct: 1907 EAEERADIAESQVNKLRAKSRDIGAKQKM 1935
Score = 96.3 bits (238), Expect = 2e-19
Identities = 127/609 (20%), Positives = 271/609 (44%), Gaps = 73/609 (11%)
Query: 732 QMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVS 791
+ EK + E+ ++E LE + EE++ ++ E + L +VQ A+Q++
Sbjct: 846 ETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQ---AEQDNLND 902
Query: 792 FASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLE 851
++L K + + K+K + E LE E A + L+ E LK++I +++L
Sbjct: 903 AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELT 962
Query: 852 KAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL-QEENESLKAH 910
A KV++ ++ + K + + A L+E L K LQ+ Q+ + L+
Sbjct: 963 LA-------KVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVE 1015
Query: 911 VQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQD-- 968
+V + + Q ++LE L++++ LE ++ E DL + + D+++
Sbjct: 1016 EDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1075
Query: 969 ---ENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQ 1025
E KL K + + + QQN + +L K + E + I L EL++ + A
Sbjct: 1076 LQLEEKLKKKEFD-INQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKV 1134
Query: 1026 RKKNNERQQQVE-------------AVELEAKEVLKKLFPKVS---VPSNLSYGEWLHGF 1069
K ++ +++E +V++E + + F K+ + L +
Sbjct: 1135 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1194
Query: 1070 EKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKS---VLAETEGILQKLQR 1126
KK + +A E++ L+ ++ ++ + +LE + S + + + L+K+ R
Sbjct: 1195 RKKHADSVAEL--GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSR 1252
Query: 1127 SVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEK 1186
++E + N+++VK++E+ +++ + FT+ + +L++EN ++ E+E L +L +
Sbjct: 1253 TLEDQANEYRVKLEEAQRSL----NDFTT---QRAKLQTENGELARQLEEKEALISQLTR 1305
Query: 1187 AEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGD 1246
++ +Y ++ +LK QL E E + +A L A+ +L++ + +
Sbjct: 1306 GKL---SYTQQMEDLKRQLEE-------EGKAKNALAHALQSARHDCDLLREQYEEETEA 1355
Query: 1247 TTVIE------NSDVSP-----ETE----SSEKETMSVSLNQTVTQLQQLLQAVN---QQ 1288
++ NS+V+ ET+ + E E L Q + ++ ++AVN
Sbjct: 1356 KAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSS 1415
Query: 1289 LTKEKEHYQ 1297
L K K Q
Sbjct: 1416 LEKTKHRLQ 1424
Score = 78.2 bits (191), Expect = 5e-14
Identities = 105/503 (20%), Positives = 224/503 (44%), Gaps = 50/503 (9%)
Query: 821 LLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQ----QLSITSKVQELQNLLKGKEEQM 876
LLK A EK + +K+E +KE + + + + +S+ + +LQ ++ +++ +
Sbjct: 841 LLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNL 900
Query: 877 NTM----------KAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSAS 926
N K LE K K++ + L+D +E N L A +++ E S
Sbjct: 901 NDAEERCDQLIKNKIQLEAKVKEM---NERLEDEEEMNAELTAKKRKLED----ECSELK 953
Query: 927 Q-FEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKS---------Q 976
+ ++LE+ L + E E E +K +++ +++ + E K + Q
Sbjct: 954 KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQ 1013
Query: 977 IEQLKQQNYQQAS-SFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQ 1035
+E+ K + ++ + L+ E+EK++ +L+ K +E K E
Sbjct: 1014 VEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVR---MDLERAKRKLEGDLKLTQESIMD 1070
Query: 1036 VEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHG--FEKKAKECMAGTSGSEEVKVLEHKL 1093
+E +L+ +E LKK ++ ++ E + +KK KE A EE E
Sbjct: 1071 LENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTA 1130
Query: 1094 K-EADEMHTLLQLECEKYKSVLAETEGILQ-KLQRSVEQEENKWKVKVDESHKTIKQMQS 1151
+ + +++ + L E E+ L E G +++ + ++E K++ D T++ +
Sbjct: 1131 RAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEAT 1190
Query: 1152 SFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRE-LKAQLNETLT 1210
+ ++ + + + I+NL+R ++ LE E + ++E + + + +KA+ N L
Sbjct: 1191 AAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAN--LE 1248
Query: 1211 KL-RTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSV 1269
K+ RT +++ + L +AQ+SL ++ K EN +++ + E EKE +
Sbjct: 1249 KVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQ-----TENGELARQLE--EKEALIS 1301
Query: 1270 SLNQTVTQLQQLLQAVNQQLTKE 1292
L + Q ++ + +QL +E
Sbjct: 1302 QLTRGKLSYTQQMEDLKRQLEEE 1324
Score = 58.9 bits (141), Expect = 3e-08
Identities = 92/429 (21%), Positives = 178/429 (41%), Gaps = 56/429 (13%)
Query: 919 LKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIE 978
LK A + + ++ + L++ EA KE E + S Q D+Q + + + +
Sbjct: 842 LKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLN 901
Query: 979 QLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEA 1038
+++ Q + E +K ++ER ++ + EL + K +E + +E ++ ++
Sbjct: 902 DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE---CSELKKDIDD 958
Query: 1039 VELEAKEVLKKLFPKVSVPSNLSYGEWLHGF---------EKKAKECMAGTSGSEEVKVL 1089
+EL +V K+ + NL+ E + G EKKA + A ++++V
Sbjct: 959 LELTLAKVEKEKHATENKVKNLT--EEMAGLDEIIAKLTKEKKALQ-EAHQQALDDLQVE 1015
Query: 1090 EHKLKEADEMHTLLQLECEKYKSVLAE--------------TEGILQKLQRSVEQEENKW 1135
E K+ + L+ + + + L + EG L+ Q S+ EN
Sbjct: 1016 EDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEND- 1074
Query: 1136 KVKVDESHKTIK---QMQSSFTSSEQEL-----ERLRSENKDIENLRREREHLEMELEKA 1187
K++++E K + Q+S EQ L ++L+ IE L E E K
Sbjct: 1075 KLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKV 1134
Query: 1188 EMERSTYVTEVRELKAQLNET--LTKLRTEQNER-----QKVAGDLHKAQQSLELIQSKI 1240
E RS E+ E+ +L E T ++ E N++ QK+ DL +A E + +
Sbjct: 1135 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1194
Query: 1241 VKAAGDTTV-----IENSDVSPETESSEKETMSVSLNQTVTQLQQLLQA------VNQQL 1289
K D+ I+N + EK + L+ + ++Q+++A V++ L
Sbjct: 1195 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTL 1254
Query: 1290 TKEKEHYQV 1298
+ Y+V
Sbjct: 1255 EDQANEYRV 1263
Score = 38.5 bits (88), Expect = 0.042
Identities = 45/224 (20%), Positives = 101/224 (45%), Gaps = 17/224 (7%)
Query: 1085 EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQR---SVEQEENKWKVKVDE 1141
++K L + EM T+ + E + K L ++E ++L+ S+ QE+N +++V
Sbjct: 837 KIKPLLKSAETEKEMATMKE-EFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQA 895
Query: 1142 SHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMEL--EKAEMERSTYVTEVR 1199
+ + + +L ++ K++ + E + EL +K ++E E
Sbjct: 896 EQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE-----DECS 950
Query: 1200 ELKAQLNE---TLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVS 1256
ELK +++ TL K+ E++ + +L + L+ I +K+ K + ++ +
Sbjct: 951 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTK---EKKALQEAHQQ 1007
Query: 1257 PETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
+ +E SL+++ +L+Q + + L +EK+ LE
Sbjct: 1008 ALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLE 1051
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.122 0.309
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,467,373
Number of Sequences: 37866
Number of extensions: 2003908
Number of successful extensions: 35835
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 560
Number of HSP's successfully gapped in prelim test: 1716
Number of HSP's that attempted gapping in prelim test: 11029
Number of HSP's gapped (non-prelim): 11065
length of query: 1300
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1186
effective length of database: 13,930,794
effective search space: 16521921684
effective search space used: 16521921684
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.