Search of human proteins with 118498341

Search of human proteins with 118498341

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|118498341 chymotrypsin B1 [Homo sapiens]
         (263 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|118498341 chymotrypsin B1 [Homo sapiens]                           543   e-155
gi|118498350 chymotrypsin B2 [Homo sapiens]                           524   e-149
gi|4503137 chymotrypsin-like [Homo sapiens]                           306   2e-83
gi|6679625 elastase 3B, pancreatic preproprotein [Homo sapiens]       193   1e-49
gi|62526043 chymotrypsin C preproprotein [Homo sapiens]               189   2e-48
gi|236460050 elastase 3A, pancreatic preproprotein [Homo sapiens]     186   2e-47
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap...   180   1e-45
gi|15559207 elastase 2A preproprotein [Homo sapiens]                  179   2e-45
gi|4505881 plasminogen [Homo sapiens]                                 176   1e-44
gi|33667063 transmembrane protease, serine 9 [Homo sapiens]           176   2e-44
gi|4506145 protease, serine, 1 preproprotein [Homo sapiens]           174   9e-44
gi|4506147 protease, serine, 2 preproprotein [Homo sapiens]           174   9e-44
gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens]       173   1e-43
gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens]        173   1e-43
gi|170932492 transmembrane protease, serine 5 [Homo sapiens]          172   3e-43
gi|4503627 coagulation factor XI precursor [Homo sapiens]             171   5e-43
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]             171   6e-43
gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sa...   169   3e-42
gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sap...   169   3e-42
gi|68508970 tryptase beta 2 precursor [Homo sapiens]                  169   3e-42
gi|4506153 prostasin preproprotein [Homo sapiens]                     168   5e-42
gi|116292750 lipoprotein Lp(a) precursor [Homo sapiens]               167   7e-42
gi|13994276 marapsin [Homo sapiens]                                   166   2e-41
gi|58331211 elastase 2B preproprotein [Homo sapiens]                  166   3e-41
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa...   165   3e-41
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa...   165   3e-41
gi|13775595 tryptase alpha/beta 1 precursor [Homo sapiens]            165   3e-41
gi|110815798 ovochymase 1 [Homo sapiens]                              162   3e-40
gi|11415040 matriptase [Homo sapiens]                                 162   4e-40
gi|33695155 hepsin [Homo sapiens]                                     161   6e-40

>gi|118498341 chymotrypsin B1 [Homo sapiens]
          Length = 263

 Score =  543 bits (1399), Expect = e-155
 Identities = 263/263 (100%), Positives = 263/263 (100%)

Query: 1   MASLWLLSCFSLVGAAFGCGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQDKTGFHFC 60
           MASLWLLSCFSLVGAAFGCGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQDKTGFHFC
Sbjct: 1   MASLWLLSCFSLVGAAFGCGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQDKTGFHFC 60

Query: 61  GGSLISEDWVVTAAHCGVRTSDVVVAGEFDQGSDEENIQVLKIAKVFKNPKFSILTVNND 120
           GGSLISEDWVVTAAHCGVRTSDVVVAGEFDQGSDEENIQVLKIAKVFKNPKFSILTVNND
Sbjct: 61  GGSLISEDWVVTAAHCGVRTSDVVVAGEFDQGSDEENIQVLKIAKVFKNPKFSILTVNND 120

Query: 121 ITLLKLATPARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPL 180
           ITLLKLATPARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPL
Sbjct: 121 ITLLKLATPARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPL 180

Query: 181 LSNAECKKSWGRRITDVMICAGASGVSSCMGDSGGPLVCQKDGAWTLVGIVSWGSDTCST 240
           LSNAECKKSWGRRITDVMICAGASGVSSCMGDSGGPLVCQKDGAWTLVGIVSWGSDTCST
Sbjct: 181 LSNAECKKSWGRRITDVMICAGASGVSSCMGDSGGPLVCQKDGAWTLVGIVSWGSDTCST 240

Query: 241 SSPGVYARVTKLIPWVQKILAAN 263
           SSPGVYARVTKLIPWVQKILAAN
Sbjct: 241 SSPGVYARVTKLIPWVQKILAAN 263


>gi|118498350 chymotrypsin B2 [Homo sapiens]
          Length = 263

 Score =  524 bits (1349), Expect = e-149
 Identities = 252/263 (95%), Positives = 257/263 (97%)

Query: 1   MASLWLLSCFSLVGAAFGCGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQDKTGFHFC 60
           MA LWLLSC++L+G  FGCGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQDKTGFHFC
Sbjct: 1   MAFLWLLSCWALLGTTFGCGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQDKTGFHFC 60

Query: 61  GGSLISEDWVVTAAHCGVRTSDVVVAGEFDQGSDEENIQVLKIAKVFKNPKFSILTVNND 120
           GGSLISEDWVVTAAHCGVRTSDVVVAGEFDQGSDEENIQVLKIAKVFKNPKFSILTVNND
Sbjct: 61  GGSLISEDWVVTAAHCGVRTSDVVVAGEFDQGSDEENIQVLKIAKVFKNPKFSILTVNND 120

Query: 121 ITLLKLATPARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPL 180
           ITLLKLATPARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPL
Sbjct: 121 ITLLKLATPARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPL 180

Query: 181 LSNAECKKSWGRRITDVMICAGASGVSSCMGDSGGPLVCQKDGAWTLVGIVSWGSDTCST 240
           LSNAECKKSWGRRITDVMICAGASGVSSCMGDSGGPLVCQKDGAWTLVGIVSWGS TCST
Sbjct: 181 LSNAECKKSWGRRITDVMICAGASGVSSCMGDSGGPLVCQKDGAWTLVGIVSWGSRTCST 240

Query: 241 SSPGVYARVTKLIPWVQKILAAN 263
           ++P VYARV KLIPWVQKILAAN
Sbjct: 241 TTPAVYARVAKLIPWVQKILAAN 263


>gi|4503137 chymotrypsin-like [Homo sapiens]
          Length = 264

 Score =  306 bits (783), Expect = 2e-83
 Identities = 142/264 (53%), Positives = 186/264 (70%), Gaps = 1/264 (0%)

Query: 1   MASLWLLSCFSLVGAAFGCGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQDKTGFHFC 60
           M  L L     L+G+++GCG+PAI P LS   RIVNGE+AV GSWPWQVSLQD +GFHFC
Sbjct: 1   MLLLSLTLSLVLLGSSWGCGIPAIKPALSFSQRIVNGENAVLGSWPWQVSLQDSSGFHFC 60

Query: 61  GGSLISEDWVVTAAHCGVRTS-DVVVAGEFDQGSDEENIQVLKIAKVFKNPKFSILTVNN 119
           GGSLIS+ WVVTAAHC V      VV GE+D+ S+ E +QVL +++   +P ++  T+NN
Sbjct: 61  GGSLISQSWVVTAAHCNVSPGRHFVVLGEYDRSSNAEPLQVLSVSRAITHPSWNSTTMNN 120

Query: 120 DITLLKLATPARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALP 179
           D+TLLKLA+PA+++  +S VCL S+++    G  C TTGWG+     N TP  LQQ ALP
Sbjct: 121 DVTLLKLASPAQYTTRISPVCLASSNEALTEGLTCVTTGWGRLSGVGNVTPAHLQQVALP 180

Query: 180 LLSNAECKKSWGRRITDVMICAGASGVSSCMGDSGGPLVCQKDGAWTLVGIVSWGSDTCS 239
           L++  +C++ WG  ITD MICAG +G SSC GDSGGPLVCQK   W L+GIVSWG+  C+
Sbjct: 181 LVTVNQCRQYWGSSITDSMICAGGAGASSCQGDSGGPLVCQKGNTWVLIGIVSWGTKNCN 240

Query: 240 TSSPGVYARVTKLIPWVQKILAAN 263
             +P VY RV+K   W+ +++A N
Sbjct: 241 VRAPAVYTRVSKFSTWINQVIAYN 264


>gi|6679625 elastase 3B, pancreatic preproprotein [Homo sapiens]
          Length = 270

 Score =  193 bits (490), Expect = 1e-49
 Identities = 121/274 (44%), Positives = 158/274 (57%), Gaps = 20/274 (7%)

Query: 4   LWLLSCFSLVGAAFGCGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQ-DKTG--FHFC 60
           L LLS   LV  A G G P+  P     SR+VNGEDAVP SWPWQVSLQ +K+G  +H C
Sbjct: 3   LRLLSSLLLVAVASGYGPPSSRPS----SRVVNGEDAVPYSWPWQVSLQYEKSGSFYHTC 58

Query: 61  GGSLISEDWVVTAAHC--GVRTSDVVVAGEFDQGSDEENIQVLKI--AKVFKNPKF--SI 114
           GGSLI+ DWVVTA HC    RT  VV+ GE+D+   E   QV+ I    +F +P +  S 
Sbjct: 59  GGSLIAPDWVVTAGHCISSSRTYQVVL-GEYDRAVKEGPEQVIPINSGDLFVHPLWNRSC 117

Query: 115 LTVNNDITLLKLATPARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQ 174
           +   NDI L+KL+  A+    V    LP A D  P  T C  TGWG+  Y     PDKLQ
Sbjct: 118 VACGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNETPCYITGWGRL-YTNGPLPDKLQ 176

Query: 175 QAALPLLSNAECKK--SWGRRITDVMICAGASGVSSCMGDSGGPLVC-QKDGAWTLVGIV 231
           +A LP++    C +   WG  +   M+CAG    S C GDSGGPL C  +DG W + G+ 
Sbjct: 177 EALLPVVDYEHCSRWNWWGSSVKKTMVCAGGDIRSGCNGDSGGPLNCPTEDGGWQVHGVT 236

Query: 232 SWGSD-TCST-SSPGVYARVTKLIPWVQKILAAN 263
           S+ S   C+T   P V+ RV+  I W+++ +A++
Sbjct: 237 SFVSAFGCNTRRKPTVFTRVSAFIDWIEETIASH 270


>gi|62526043 chymotrypsin C preproprotein [Homo sapiens]
          Length = 268

 Score =  189 bits (480), Expect = 2e-48
 Identities = 110/259 (42%), Positives = 150/259 (57%), Gaps = 14/259 (5%)

Query: 11  SLVGAAFGCGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQ---DKTGFHFCGGSLISE 67
           +L+  A  CGVP+  P LS  +R+V GEDA P SWPWQ+SLQ   + T  H CGG+LI+ 
Sbjct: 9   ALLACASSCGVPSFPPNLS--ARVVGGEDARPHSWPWQISLQYLKNDTWRHTCGGTLIAS 66

Query: 68  DWVVTAAHC--GVRTSDVVVAGEFDQGSDEENIQVLKIAKVFKNPKFSILTVNNDITLLK 125
           ++V+TAAHC    RT  V V     +  DEE    + +  +  + +++ L + NDI L+K
Sbjct: 67  NFVLTAAHCISNTRTYRVAVGKNNLEVEDEEGSLFVGVDTIHVHKRWNALLLRNDIALIK 126

Query: 126 LATPARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLSNAE 185
           LA     S T+   CLP  D   P    C  TGWG+   N     DKLQQ   P++ +A 
Sbjct: 127 LAEHVELSDTIQVACLPEKDSLLPKDYPCYVTGWGRLWTN-GPIADKLQQGLQPVVDHAT 185

Query: 186 CKKS--WGRRITDVMICAGASGV-SSCMGDSGGPLVCQ-KDGAWTLVGIVSWGSDT-CST 240
           C +   WG R+   M+CAG  GV S+C GDSGGPL CQ ++G+W + GIVS+GS   C+T
Sbjct: 186 CSRIDWWGFRVKKTMVCAGGDGVISACNGDSGGPLNCQLENGSWEVFGIVSFGSRRGCNT 245

Query: 241 -SSPGVYARVTKLIPWVQK 258
              P VY RV+  I W+ +
Sbjct: 246 RKKPVVYTRVSAYIDWINE 264


>gi|236460050 elastase 3A, pancreatic preproprotein [Homo sapiens]
          Length = 270

 Score =  186 bits (471), Expect = 2e-47
 Identities = 118/273 (43%), Positives = 156/273 (57%), Gaps = 18/273 (6%)

Query: 4   LWLLSCFSLVGAAFGCGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQ-DKTG--FHFC 60
           L LLS   LV  A G G P+ H      SR+V+GEDAVP SWPWQVSLQ +K+G  +H C
Sbjct: 3   LRLLSSLLLVAVASGYGPPSSH----SSSRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTC 58

Query: 61  GGSLISEDWVVTAAHCGVR-TSDVVVAGEFDQGSDEENIQVLKI--AKVFKNPKF--SIL 115
           GGSLI+ DWVVTA HC  R  +  VV GE++    E   QV+ I   ++F +P +  S +
Sbjct: 59  GGSLIAPDWVVTAGHCISRDLTYQVVLGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCV 118

Query: 116 TVNNDITLLKLATPARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQ 175
              NDI L+KL+  A+    V    LP A D  P  T C  TGWG+  Y     PDKLQQ
Sbjct: 119 ACGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNKTPCYITGWGRL-YTNGPLPDKLQQ 177

Query: 176 AALPLLSNAECKK--SWGRRITDVMICAGASGVSSCMGDSGGPLVC-QKDGAWTLVGIVS 232
           A LP++    C +   WG  +   M+CAG    S C GDSGGPL C  +DG W + G+ S
Sbjct: 178 ARLPVVDYKHCSRWNWWGSTVKKTMVCAGGYIRSGCNGDSGGPLNCPTEDGGWQVHGVTS 237

Query: 233 WGSD-TCS-TSSPGVYARVTKLIPWVQKILAAN 263
           + S   C+    P V+ RV+  I W+++ +A++
Sbjct: 238 FVSAFGCNFIWKPTVFTRVSAFIDWIEETIASH 270


>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
           sapiens]
          Length = 454

 Score =  180 bits (456), Expect = 1e-45
 Identities = 95/238 (39%), Positives = 135/238 (56%), Gaps = 17/238 (7%)

Query: 32  SRIVNGEDAVPGSWPWQVSLQDKTGFHFCGGSLISEDWVVTAAHCGVR-------TSDVV 84
           SRIV G  ++   WPWQ SLQ + G+H CGGS+I+  W++TAAHC          T  V 
Sbjct: 215 SRIVGGNMSLLSQWPWQASLQFQ-GYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVG 273

Query: 85  VAGEFDQGSDEENIQVLKIAKVFKNPKFSILTVNNDITLLKLATPARFSQTVSAVCLPSA 144
           +    D  +    ++     K+  + K+    + NDI L+KLA P  F++ +  VCLP++
Sbjct: 274 LVSLLDNPAPSHLVE-----KIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNS 328

Query: 145 DDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLSNAEC--KKSWGRRITDVMICAG 202
           +++FP G +C T+GWG T+  A      L  AA+PL+SN  C  +  +G  I+  M+CAG
Sbjct: 329 EENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAG 388

Query: 203 --ASGVSSCMGDSGGPLVCQKDGAWTLVGIVSWGSDTCSTSSPGVYARVTKLIPWVQK 258
               GV SC GDSGGPLVCQ+   W LVG  S+G      + PGVY RVT  + W+ +
Sbjct: 389 YLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHE 446


>gi|15559207 elastase 2A preproprotein [Homo sapiens]
          Length = 269

 Score =  179 bits (455), Expect = 2e-45
 Identities = 112/266 (42%), Positives = 145/266 (54%), Gaps = 18/266 (6%)

Query: 11  SLVGAAFGCGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQDKTG---FHFCGGSLISE 67
           +LV  A  CG P   P ++   R+V GE+A P SWPWQVSLQ  +    +H CGGSLI+ 
Sbjct: 9   TLVAGALSCGDPTYPPYVT---RVVGGEEARPNSWPWQVSLQYSSNGKWYHTCGGSLIAN 65

Query: 68  DWVVTAAHC--GVRTSDVVVAGEFDQGSDEENIQVLKIAK--VFKNPKFSILTVNNDITL 123
            WV+TAAHC    RT  V + G  +    E     + ++K  V K+   + ++  NDI L
Sbjct: 66  SWVLTAAHCISSSRTYRVGL-GRHNLYVAESGSLAVSVSKIVVHKDWNSNQISKGNDIAL 124

Query: 124 LKLATPARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLSN 183
           LKLA P   +  +   CLP A    P    C  TGWG+ + N    PD LQQ  L ++  
Sbjct: 125 LKLANPVSLTDKIQLACLPPAGTILPNNYPCYVTGWGRLQTN-GAVPDVLQQGRLLVVDY 183

Query: 184 AECKKS--WGRRITDVMICAGASGV-SSCMGDSGGPLVCQ-KDGAWTLVGIVSWGSDT-C 238
           A C  S  WG  +   MICAG  GV SSC GDSGGPL CQ  DG W + GIVS+GS   C
Sbjct: 184 ATCSSSAWWGSSVKTSMICAGGDGVISSCNGDSGGPLNCQASDGRWQVHGIVSFGSRLGC 243

Query: 239 S-TSSPGVYARVTKLIPWVQKILAAN 263
           +    P V+ RV+  I W+  ++A N
Sbjct: 244 NYYHKPSVFTRVSNYIDWINSVIANN 269


>gi|4505881 plasminogen [Homo sapiens]
          Length = 810

 Score =  176 bits (447), Expect = 1e-44
 Identities = 97/256 (37%), Positives = 142/256 (55%), Gaps = 17/256 (6%)

Query: 16  AFGCGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQDKTGFHFCGGSLISEDWVVTAAH 75
           +F CG P + P      R+V G  A P SWPWQVSL+ + G HFCGG+LIS +WV+TAAH
Sbjct: 564 SFDCGKPQVEPKKCP-GRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAH 622

Query: 76  CGVR----TSDVVVAGEFDQGSDEENIQVLKIAKVFKNPKFSILTVNNDITLLKLATPAR 131
           C  +    +S  V+ G   + + E ++Q ++++++F  P         DI LLKL++PA 
Sbjct: 623 CLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEP------TRKDIALLKLSSPAV 676

Query: 132 FSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLSNAECKK--S 189
            +  V   CLPS +      T C  TGWG+T+         L++A LP++ N  C +   
Sbjct: 677 ITDKVIPACLPSPNYVVADRTECFITGWGETQ--GTFGAGLLKEAQLPVIENKVCNRYEF 734

Query: 190 WGRRITDVMICAG--ASGVSSCMGDSGGPLVCQKDGAWTLVGIVSWGSDTCSTSSPGVYA 247
              R+    +CAG  A G  SC GDSGGPLVC +   + L G+ SWG      + PGVY 
Sbjct: 735 LNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYV 794

Query: 248 RVTKLIPWVQKILAAN 263
           RV++ + W++ ++  N
Sbjct: 795 RVSRFVTWIEGVMRNN 810


>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
          Length = 1059

 Score =  176 bits (445), Expect = 2e-44
 Identities = 95/246 (38%), Positives = 137/246 (55%), Gaps = 13/246 (5%)

Query: 19  CGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQDKTGFHFCGGSLISEDWVVTAAHCGV 78
           CG   + P      RIV G +A PG +PWQ SL++    HFCG ++I+  W+V+AAHC  
Sbjct: 191 CG---LQPAWRMAGRIVGGMEASPGEFPWQASLRENKE-HFCGAAIINARWLVSAAHCFN 246

Query: 79  RTSD-----VVVAGEFDQGSDEENIQVLKIAKVFKNPKFSILTVNNDITLLKLATPARFS 133
              D       V   +  GS+   ++  ++ ++ K+P ++  T + D+ +L+L +P  F 
Sbjct: 247 EFQDPTKWVAYVGATYLSGSEASTVRA-QVVQIVKHPLYNADTADFDVAVLELTSPLPFG 305

Query: 134 QTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLSNAECKKSWGRR 193
           + +  VCLP+A   FP    C  +GWG  K +    P+ LQ+A + LL  A C   +G  
Sbjct: 306 RHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCASLYGHS 365

Query: 194 ITDVMICAG--ASGVSSCMGDSGGPLVCQK-DGAWTLVGIVSWGSDTCSTSSPGVYARVT 250
           +TD M+CAG     V SC GDSGGPLVC++  G + L GIVSWG        PGVYARVT
Sbjct: 366 LTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVT 425

Query: 251 KLIPWV 256
           +L  W+
Sbjct: 426 RLRDWI 431



 Score =  166 bits (419), Expect = 3e-41
 Identities = 90/236 (38%), Positives = 133/236 (56%), Gaps = 12/236 (5%)

Query: 29   SGLSRIVNGEDAVPGSWPWQVSLQDKTGFHFCGGSLISEDWVVTAAHCGVRTSD-----V 83
            + L+RIV G  A  G WPWQVSL  +   H CG  L++E W+++AAHC     D      
Sbjct: 822  AALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAA 881

Query: 84   VVAGEFDQGSDEENIQVLKIAKVFKNPKFSILTVNNDITLLKLATPARFSQTVSAVCLPS 143
             +   F  G++    Q+ ++A+++K+P +++ T++ D+ LL+LA P R S+ V  +CLP 
Sbjct: 882  FLGTPFLSGAEG---QLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPE 938

Query: 144  ADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLSNAECKKSWGRRITDVMICAG- 202
                 P GT C  TGWG  +        +LQ+AA+ LLS   C++ +  +I+  M+CAG 
Sbjct: 939  PAPRPPDGTRCVITGWGSVR-EGGSMARQLQKAAVRLLSEQTCRRFYPVQISSRMLCAGF 997

Query: 203  -ASGVSSCMGDSGGPLVCQK-DGAWTLVGIVSWGSDTCSTSSPGVYARVTKLIPWV 256
               GV SC GD+GGPL C++  G W L G+ SWG        PGVY RV  +  W+
Sbjct: 998  PQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWI 1053



 Score =  159 bits (402), Expect = 2e-39
 Identities = 87/251 (34%), Positives = 137/251 (54%), Gaps = 12/251 (4%)

Query: 19  CGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQDKTGFHFCGGSLISEDWVVTAAHCGV 78
           CG     P +   +R+V G  A  G  PWQVSL++ +  HFCG +++ + W+++AAHC  
Sbjct: 492 CGA---RPAMEKPTRVVGGFGAASGEVPWQVSLKEGSR-HFCGATVVGDRWLLSAAHCFN 547

Query: 79  RTSDVVVAGEFDQGS----DEENIQVLKIAKVFKNPKFSILTVNNDITLLKLATPARFSQ 134
            T    V       S        +++  + +V  +P ++   ++ D+ +L+LA+P  F++
Sbjct: 548 HTKVEQVRAHLGTASLLGLGGSPVKI-GLRRVVLHPLYNPGILDFDLAVLELASPLAFNK 606

Query: 135 TVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLSNAECKKSWGRRI 194
            +  VCLP A   FP G  C  +GWG T+      P+ LQ+A++ ++    C   +   +
Sbjct: 607 YIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSVLYNFSL 666

Query: 195 TDVMICAG--ASGVSSCMGDSGGPLVCQK-DGAWTLVGIVSWGSDTCSTSSPGVYARVTK 251
           TD MICAG     V SC GDSGGPL C++  G + L GIVSWG        PGVY R+T+
Sbjct: 667 TDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRITR 726

Query: 252 LIPWVQKILAA 262
           L  W+ +I+++
Sbjct: 727 LKGWILEIMSS 737


>gi|4506145 protease, serine, 1 preproprotein [Homo sapiens]
          Length = 247

 Score =  174 bits (440), Expect = 9e-44
 Identities = 96/233 (41%), Positives = 135/233 (57%), Gaps = 11/233 (4%)

Query: 33  RIVNGEDAVPGSWPWQVSLQDKTGFHFCGGSLISEDWVVTAAHCGVRTSDVVVAGEFDQG 92
           +IV G +    S P+QVSL   +G+HFCGGSLI+E WVV+A HC  ++   V  GE +  
Sbjct: 23  KIVGGYNCEENSVPYQVSLN--SGYHFCGGSLINEQWVVSAGHC-YKSRIQVRLGEHNIE 79

Query: 93  SDEENIQVLKIAKVFKNPKFSILTVNNDITLLKLATPARFSQTVSAVCLPSADDDFPAGT 152
             E N Q +  AK+ ++P++   T+NNDI L+KL++ A  +  VS + LP+A      GT
Sbjct: 80  VLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPP--ATGT 137

Query: 153 LCATTGWGKTKYNANKTPDKLQQAALPLLSNAECKKSWGRRITDVMICAG--ASGVSSCM 210
            C  +GWG T  +    PD+LQ    P+LS A+C+ S+  +IT  M C G    G  SC 
Sbjct: 138 KCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQ 197

Query: 211 GDSGGPLVCQKDGAWTLVGIVSWGSDTCSTSSPGVYARVTKLIPWVQKILAAN 263
           GDSGGP+VC       L G+VSWG      + PGVY +V   + W++  +AAN
Sbjct: 198 GDSGGPVVCNGQ----LQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAAN 246


>gi|4506147 protease, serine, 2 preproprotein [Homo sapiens]
          Length = 247

 Score =  174 bits (440), Expect = 9e-44
 Identities = 100/233 (42%), Positives = 138/233 (59%), Gaps = 11/233 (4%)

Query: 33  RIVNGEDAVPGSWPWQVSLQDKTGFHFCGGSLISEDWVVTAAHCGVRTSDVVVAGEFDQG 92
           +IV G      S P+QVSL   +G+HFCGGSLISE WVV+A HC  ++   V  GE +  
Sbjct: 23  KIVGGYICEENSVPYQVSLN--SGYHFCGGSLISEQWVVSAGHC-YKSRIQVRLGEHNIE 79

Query: 93  SDEENIQVLKIAKVFKNPKFSILTVNNDITLLKLATPARFSQTVSAVCLPSADDDFPAGT 152
             E N Q +  AK+ ++PK++  T++NDI L+KL++PA  +  VSA+ LP+A     AGT
Sbjct: 80  VLEGNEQFINAAKIIRHPKYNSRTLDNDILLIKLSSPAVINSRVSAISLPTAPP--AAGT 137

Query: 153 LCATTGWGKTKYNANKTPDKLQQAALPLLSNAECKKSWGRRITDVMICAG--ASGVSSCM 210
               +GWG T  +    PD+LQ    P+LS AEC+ S+  +IT+ M C G    G  SC 
Sbjct: 138 ESLISGWGNTLSSGADYPDELQCLDAPVLSQAECEASYPGKITNNMFCVGFLEGGKDSCQ 197

Query: 211 GDSGGPLVCQKDGAWTLVGIVSWGSDTCSTSSPGVYARVTKLIPWVQKILAAN 263
           GDSGGP+V   +    L GIVSWG      + PGVY +V   + W++  +AAN
Sbjct: 198 GDSGGPVVSNGE----LQGIVSWGYGCAQKNRPGVYTKVYNYVDWIKDTIAAN 246


>gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens]
          Length = 304

 Score =  173 bits (439), Expect = 1e-43
 Identities = 100/233 (42%), Positives = 136/233 (58%), Gaps = 11/233 (4%)

Query: 33  RIVNGEDAVPGSWPWQVSLQDKTGFHFCGGSLISEDWVVTAAHCGVRTSDVVVAGEFDQG 92
           +IV G      S P+QVSL   +G HFCGGSLISE WVV+AAHC  +T   V  GE +  
Sbjct: 80  KIVGGYTCEENSLPYQVSLN--SGSHFCGGSLISEQWVVSAAHC-YKTRIQVRLGEHNIK 136

Query: 93  SDEENIQVLKIAKVFKNPKFSILTVNNDITLLKLATPARFSQTVSAVCLPSADDDFPAGT 152
             E N Q +  AK+ ++PK++  T++NDI L+KL++PA  +  VS + LP+A     AGT
Sbjct: 137 VLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPTAPP--AAGT 194

Query: 153 LCATTGWGKTKYNANKTPDKLQQAALPLLSNAECKKSWGRRITDVMICAG--ASGVSSCM 210
            C  +GWG T       PD+L+    P+L+ AECK S+  +IT+ M C G    G  SC 
Sbjct: 195 ECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQ 254

Query: 211 GDSGGPLVCQKDGAWTLVGIVSWGSDTCSTSSPGVYARVTKLIPWVQKILAAN 263
            DSGGP+VC       L G+VSWG      + PGVY +V   + W++  +AAN
Sbjct: 255 RDSGGPVVCNGQ----LQGVVSWGHGCAWKNRPGVYTKVYNYVDWIKDTIAAN 303


>gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens]
          Length = 247

 Score =  173 bits (439), Expect = 1e-43
 Identities = 100/233 (42%), Positives = 136/233 (58%), Gaps = 11/233 (4%)

Query: 33  RIVNGEDAVPGSWPWQVSLQDKTGFHFCGGSLISEDWVVTAAHCGVRTSDVVVAGEFDQG 92
           +IV G      S P+QVSL   +G HFCGGSLISE WVV+AAHC  +T   V  GE +  
Sbjct: 23  KIVGGYTCEENSLPYQVSLN--SGSHFCGGSLISEQWVVSAAHC-YKTRIQVRLGEHNIK 79

Query: 93  SDEENIQVLKIAKVFKNPKFSILTVNNDITLLKLATPARFSQTVSAVCLPSADDDFPAGT 152
             E N Q +  AK+ ++PK++  T++NDI L+KL++PA  +  VS + LP+A     AGT
Sbjct: 80  VLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPTAPP--AAGT 137

Query: 153 LCATTGWGKTKYNANKTPDKLQQAALPLLSNAECKKSWGRRITDVMICAG--ASGVSSCM 210
            C  +GWG T       PD+L+    P+L+ AECK S+  +IT+ M C G    G  SC 
Sbjct: 138 ECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQ 197

Query: 211 GDSGGPLVCQKDGAWTLVGIVSWGSDTCSTSSPGVYARVTKLIPWVQKILAAN 263
            DSGGP+VC       L G+VSWG      + PGVY +V   + W++  +AAN
Sbjct: 198 RDSGGPVVCNGQ----LQGVVSWGHGCAWKNRPGVYTKVYNYVDWIKDTIAAN 246


>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
          Length = 457

 Score =  172 bits (436), Expect = 3e-43
 Identities = 94/235 (40%), Positives = 124/235 (52%), Gaps = 12/235 (5%)

Query: 32  SRIVNGEDAVPGSWPWQVSLQDKTGF-HFCGGSLISEDWVVTAAHCG-----VRTSDVVV 85
           SRIV G+   PG WPWQ S+    GF H CGGS+++  WVVTAAHC       R S   V
Sbjct: 216 SRIVGGQSVAPGRWPWQASVA--LGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRV 273

Query: 86  AGEFDQGSDEENIQVLKIAKVFKNPKFSILTVNNDITLLKLATPARFSQTVSAVCLPSAD 145
                  S     Q   + ++  +P +S    + D+ LL+L T   FS TV AVCLP+ +
Sbjct: 274 HAGLVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKE 333

Query: 146 DDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLSNAECKKS--WGRRITDVMICAG- 202
             FP G+ C  +GWG T  +   + D LQ   +PL S   C  S  +   +T  M+CAG 
Sbjct: 334 QHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGY 393

Query: 203 -ASGVSSCMGDSGGPLVCQKDGAWTLVGIVSWGSDTCSTSSPGVYARVTKLIPWV 256
                 +C GDSGGPLVC     W LVG+VSWG      + PGVYA+V + + W+
Sbjct: 394 LDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWI 448


>gi|4503627 coagulation factor XI precursor [Homo sapiens]
          Length = 625

 Score =  171 bits (434), Expect = 5e-43
 Identities = 92/233 (39%), Positives = 129/233 (55%), Gaps = 10/233 (4%)

Query: 33  RIVNGEDAVPGSWPWQVSLQ--DKTGFHFCGGSLISEDWVVTAAHC--GVRTSDV--VVA 86
           RIV G  +V G WPWQV+L     T  H CGGS+I   W++TAAHC  GV +  +  V +
Sbjct: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYS 446

Query: 87  GEFDQGSDEENIQVLKIAKVFKNPKFSILTVNNDITLLKLATPARFSQTVSAVCLPSADD 146
           G  +Q   +E+     + ++  + ++ +     DI LLKL T   ++ +   +CLPS  D
Sbjct: 447 GILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGD 506

Query: 147 DFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLSNAECKKSW-GRRITDVMICAG--A 203
                T C  TGWG  K   +K  + LQ+A +PL++N EC+K + G +IT  MICAG   
Sbjct: 507 RNVIYTDCWVTGWGYRKLR-DKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYRE 565

Query: 204 SGVSSCMGDSGGPLVCQKDGAWTLVGIVSWGSDTCSTSSPGVYARVTKLIPWV 256
            G  +C GDSGGPL C+ +  W LVGI SWG        PGVY  V + + W+
Sbjct: 566 GGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWI 618


>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
          Length = 638

 Score =  171 bits (433), Expect = 6e-43
 Identities = 92/234 (39%), Positives = 132/234 (56%), Gaps = 10/234 (4%)

Query: 32  SRIVNGEDAVPGSWPWQVSLQDKTGF--HFCGGSLISEDWVVTAAHC--GVRTSDV--VV 85
           +RIV G ++  G WPWQVSLQ K     H CGGSLI   WV+TAAHC  G+   DV  + 
Sbjct: 389 TRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIY 448

Query: 86  AGEFDQGSDEENIQVLKIAKVFKNPKFSILTVNNDITLLKLATPARFSQTVSAVCLPSAD 145
           +G  +     ++    +I ++  +  + +   N+DI L+KL  P  +++    +CLPS  
Sbjct: 449 SGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLPSKG 508

Query: 146 DDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLSNAECKKSW-GRRITDVMICAG-- 202
           D     T C  TGWG +K    +  + LQ+  +PL++N EC+K +   +IT  M+CAG  
Sbjct: 509 DTSTIYTNCWVTGWGFSK-EKGEIQNILQKVNIPLVTNEECQKRYQDYKITQRMVCAGYK 567

Query: 203 ASGVSSCMGDSGGPLVCQKDGAWTLVGIVSWGSDTCSTSSPGVYARVTKLIPWV 256
             G  +C GDSGGPLVC+ +G W LVGI SWG        PGVY +V + + W+
Sbjct: 568 EGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWI 621


>gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo
           sapiens]
          Length = 432

 Score =  169 bits (427), Expect = 3e-42
 Identities = 104/262 (39%), Positives = 144/262 (54%), Gaps = 20/262 (7%)

Query: 14  GAAFGCGVPAIHPVLSGLS----RIVNGEDAVPGSWPWQVSLQ-DKTGFHFCGGSLISED 68
           G      + ++H +  G S    R+V GE+A   SWPWQVS+Q DK   H CGGS++   
Sbjct: 176 GPCLSGSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQ--HVCGGSILDPH 233

Query: 69  WVVTAAHCGVRTSDV----VVAGEFDQGSDEENIQVLKIAKVFKNPKFSILTVNNDITLL 124
           WV+TAAHC  + +DV    V AG    GS   ++ V KI  +  NP +     +NDI L+
Sbjct: 234 WVLTAAHCFRKHTDVFNWKVRAGSDKLGSFP-SLAVAKIIIIEFNPMYP---KDNDIALM 289

Query: 125 KLATPARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLSNA 184
           KL  P  FS TV  +CLP  D++    T     GWG TK N  K  D L QA++ ++ + 
Sbjct: 290 KLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDST 349

Query: 185 ECK--KSWGRRITDVMICAG--ASGVSSCMGDSGGPLVCQKDGAWTLVGIVSWGSDTCST 240
            C    ++   +T+ M+CAG    GV +C GDSGGPL+ Q D  W +VGIVSWG      
Sbjct: 350 RCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSD-QWHVVGIVSWGYGCGGP 408

Query: 241 SSPGVYARVTKLIPWVQKILAA 262
           S+PGVY +V+  + W+  +  A
Sbjct: 409 STPGVYTKVSAYLNWIYNVWKA 430


>gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo
           sapiens]
          Length = 437

 Score =  169 bits (427), Expect = 3e-42
 Identities = 104/262 (39%), Positives = 144/262 (54%), Gaps = 20/262 (7%)

Query: 14  GAAFGCGVPAIHPVLSGLS----RIVNGEDAVPGSWPWQVSLQ-DKTGFHFCGGSLISED 68
           G      + ++H +  G S    R+V GE+A   SWPWQVS+Q DK   H CGGS++   
Sbjct: 181 GPCLSGSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQ--HVCGGSILDPH 238

Query: 69  WVVTAAHCGVRTSDV----VVAGEFDQGSDEENIQVLKIAKVFKNPKFSILTVNNDITLL 124
           WV+TAAHC  + +DV    V AG    GS   ++ V KI  +  NP +     +NDI L+
Sbjct: 239 WVLTAAHCFRKHTDVFNWKVRAGSDKLGSFP-SLAVAKIIIIEFNPMYP---KDNDIALM 294

Query: 125 KLATPARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLSNA 184
           KL  P  FS TV  +CLP  D++    T     GWG TK N  K  D L QA++ ++ + 
Sbjct: 295 KLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDST 354

Query: 185 ECK--KSWGRRITDVMICAG--ASGVSSCMGDSGGPLVCQKDGAWTLVGIVSWGSDTCST 240
            C    ++   +T+ M+CAG    GV +C GDSGGPL+ Q D  W +VGIVSWG      
Sbjct: 355 RCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSD-QWHVVGIVSWGYGCGGP 413

Query: 241 SSPGVYARVTKLIPWVQKILAA 262
           S+PGVY +V+  + W+  +  A
Sbjct: 414 STPGVYTKVSAYLNWIYNVWKA 435


>gi|68508970 tryptase beta 2 precursor [Homo sapiens]
          Length = 275

 Score =  169 bits (427), Expect = 3e-42
 Identities = 99/272 (36%), Positives = 136/272 (50%), Gaps = 21/272 (7%)

Query: 1   MASLWLLSCFSLVGAAFGCGVPAIHPVLSGLSR--IVNGEDAVPGSWPWQVSLQ--DKTG 56
           M +L LL+   L   A+    P        L R  IV G++A    WPWQVSL+  D+  
Sbjct: 1   MLNLLLLALPVLASRAYAAPAPG-----QALQRVGIVGGQEAPRSKWPWQVSLRVRDRYW 55

Query: 57  FHFCGGSLISEDWVVTAAHC-GVRTSDVVVAG-EFDQGSDEENIQVLKIAKVFKNPKFSI 114
            HFCGGSLI   WV+TAAHC G    D+     +  +       Q+L ++++  +P+F  
Sbjct: 56  MHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYT 115

Query: 115 LTVNNDITLLKLATPARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPD-KL 173
             +  DI LL+L  P   S  V  V LP A + FP G  C  TGWG    +    P   L
Sbjct: 116 AQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPL 175

Query: 174 QQAALPLLSNAECKKSWG---------RRITDVMICAGASGVSSCMGDSGGPLVCQKDGA 224
           +Q  +P++ N  C   +          R + D M+CAG +   SC GDSGGPLVC+ +G 
Sbjct: 176 KQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGT 235

Query: 225 WTLVGIVSWGSDTCSTSSPGVYARVTKLIPWV 256
           W   G+VSWG      + PG+Y RVT  + W+
Sbjct: 236 WLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWI 267


>gi|4506153 prostasin preproprotein [Homo sapiens]
          Length = 343

 Score =  168 bits (425), Expect = 5e-42
 Identities = 97/259 (37%), Positives = 132/259 (50%), Gaps = 23/259 (8%)

Query: 14  GAAFGCGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQDKTGFHFCGGSLISEDWVVTA 73
           GA   CGV       +  +RI  G  AV G WPWQVS+  + G H CGGSL+SE WV++A
Sbjct: 32  GAEAPCGV-------APQARITGGSSAVAGQWPWQVSITYE-GVHVCGGSLVSEQWVLSA 83

Query: 74  AHCGV----RTSDVVVAGEFDQGSDEENIQVLKIAKVFKNPKFSILTVNNDITLLKLATP 129
           AHC      + +  V  G     S  E+ +V  +  +  +P +       DI LL+L+ P
Sbjct: 84  AHCFPSEHHKEAYEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRP 143

Query: 130 ARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANK-TPDKLQQAALPLLSNAEC-- 186
             FS+ +  +CLP+A+  FP G  C  TGWG    + +  TP  LQQ  +PL+S   C  
Sbjct: 144 ITFSRYIRPICLPAANASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNC 203

Query: 187 ------KKSWGRRITDVMICAG--ASGVSSCMGDSGGPLVCQKDGAWTLVGIVSWGSDTC 238
                 K      + + M+CAG    G  +C GDSGGPL C  +G W L GIVSWG    
Sbjct: 204 LYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGGPLSCPVEGLWYLTGIVSWGDACG 263

Query: 239 STSSPGVYARVTKLIPWVQ 257
           + + PGVY   +    W+Q
Sbjct: 264 ARNRPGVYTLASSYASWIQ 282


>gi|116292750 lipoprotein Lp(a) precursor [Homo sapiens]
          Length = 2040

 Score =  167 bits (424), Expect = 7e-42
 Identities = 99/255 (38%), Positives = 139/255 (54%), Gaps = 22/255 (8%)

Query: 15   AAFGCGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQDKTGFHFCGGSLISEDWVVTAA 74
            ++F CG P + P     S IV G  A P SWPWQVSL+ + G HFCGG+LIS +WV+TAA
Sbjct: 1802 SSFDCGKPQVEPKKCPGS-IVGGCVAHPHSWPWQVSLRTRFGKHFCGGTLISPEWVLTAA 1860

Query: 75   HCGVRTSD----VVVAGEFDQGSDEENIQVLKIAKVFKNPKFSILTVNNDITLLKLATPA 130
            HC  ++S      V+ G   + + E ++Q ++++++F  P         DI LLKL+ PA
Sbjct: 1861 HCLKKSSRPSSYKVILGAHQEVNLESHVQEIEVSRLFLEP------TQADIALLKLSRPA 1914

Query: 131  RFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLSNAECKKSW 190
              +  V   CLPS D    A T C  TGWG+T+         L++A L ++ N  C    
Sbjct: 1915 VITDKVMPACLPSPDYMVTARTECYITGWGETQ--GTFGTGLLKEAQLLVIENEVCNHY- 1971

Query: 191  GRRITDVMICAG--ASGVSSCMGDSGGPLVCQKDGAWTLVGIVSWGSDTCSTSSPGVYAR 248
                    ICA   A G  SC GDSGGPLVC +   + L G+ SWG      + PGVYAR
Sbjct: 1972 ------KYICAEHLARGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYAR 2025

Query: 249  VTKLIPWVQKILAAN 263
            V++ + W++ ++  N
Sbjct: 2026 VSRFVTWIEGMMRNN 2040


>gi|13994276 marapsin [Homo sapiens]
          Length = 290

 Score =  166 bits (420), Expect = 2e-41
 Identities = 98/275 (35%), Positives = 139/275 (50%), Gaps = 25/275 (9%)

Query: 4   LWLLSCFSL--VGAAFGCGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQDKTGFHFCG 61
           L LL CF      AA  CG P +      L+R+V G+D   G WPWQVS+Q + G HFCG
Sbjct: 9   LLLLLCFGSQRAKAATACGRPRM------LNRMVGGQDTQEGEWPWQVSIQ-RNGSHFCG 61

Query: 62  GSLISEDWVVTAAHCGVRTSDV----VVAGEFDQGSDEENIQVLKIAKVFKNPKFSILTV 117
           GSLI+E WV+TAAHC   TS+     V+ G         +    ++ +V  NP +     
Sbjct: 62  GSLIAEQWVLTAAHCFRNTSETSLYQVLLGARQLVQPGPHAMYARVRQVESNPLYQGTAS 121

Query: 118 NNDITLLKLATPARFSQTVSAVCLPSADDDFPAGTLCATTGWGK-TKYNANKTPDKLQQA 176
           + D+ L++L  P  F+  +  VCLP     F  G  C  TGWG  ++ +    P  LQ+ 
Sbjct: 122 SADVALVELEAPVPFTNYILPVCLPDPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQKL 181

Query: 177 ALPLLSNAECKKSWGR---------RITDVMICAG--ASGVSSCMGDSGGPLVCQKDGAW 225
           A+P++   +C   + +          I + M+CAG       +C GDSGGPLVC    +W
Sbjct: 182 AVPIIDTPKCNLLYSKDTEFGYQPKTIKNDMLCAGFEEGKKDACKGDSGGPLVCLVGQSW 241

Query: 226 TLVGIVSWGSDTCSTSSPGVYARVTKLIPWVQKIL 260
              G++SWG      + PGVY RVT    W+ +I+
Sbjct: 242 LQAGVISWGEGCARQNRPGVYIRVTAHHNWIHRII 276


>gi|58331211 elastase 2B preproprotein [Homo sapiens]
          Length = 269

 Score =  166 bits (419), Expect = 3e-41
 Identities = 104/266 (39%), Positives = 142/266 (53%), Gaps = 18/266 (6%)

Query: 11  SLVGAAFGCGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQDKTG---FHFCGGSLISE 67
           +LV  A  CGV    P    +SR++ GE+A P SWPWQVSLQ  +    +H CGGSLI+ 
Sbjct: 9   TLVAGALSCGVSTYAP---DMSRMLGGEEARPNSWPWQVSLQYSSNGQWYHTCGGSLIAN 65

Query: 68  DWVVTAAHCGVRTSDV--VVAGEFDQGSDEENIQVLKIAK--VFKNPKFSILTVNNDITL 123
            WV+TAAHC + +S +  V+ G+ +    E     + ++K  V K+     ++  NDI L
Sbjct: 66  SWVLTAAHC-ISSSGIYRVMLGQHNLYVAESGSLAVSVSKIVVHKDWNSDQVSKGNDIAL 124

Query: 124 LKLATPARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLSN 183
           LKLA P   +  +   CLP A    P    C  TGWG+ + N    PD L+Q  L ++  
Sbjct: 125 LKLANPVSLTDKIQLACLPPAGTILPNNYPCYVTGWGRLQTN-GALPDDLKQGRLLVVDY 183

Query: 184 AECKKS--WGRRITDVMICAGASGV-SSCMGDSGGPLVCQ-KDGAWTLVGIVSWGSDT-C 238
           A C  S  WG  +   MICAG  GV  +C GDSGGPL CQ  DG W + GI S  S   C
Sbjct: 184 ATCSSSGWWGSTVKTNMICAGGDGVICTCNGDSGGPLNCQASDGRWEVHGIGSLTSVLGC 243

Query: 239 S-TSSPGVYARVTKLIPWVQKILAAN 263
           +    P ++ RV+    W+  ++A N
Sbjct: 244 NYYYKPSIFTRVSNYNDWINSVIANN 269


>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
           sapiens]
          Length = 529

 Score =  165 bits (418), Expect = 3e-41
 Identities = 97/264 (36%), Positives = 131/264 (49%), Gaps = 10/264 (3%)

Query: 8   SCFSLVGAAFGCGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQDKTGFHFCGGSLISE 67
           +C S    +  C    ++   S  SRIV GE A+PG+WPWQVSL  +   H CGGS+I+ 
Sbjct: 267 ACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQN-VHVCGGSIITP 325

Query: 68  DWVVTAAHCGVRTSDVVVAGEFDQGSDEENIQVL----KIAKVFKNPKFSILTVNNDITL 123
           +W+VTAAHC  +  +         G   ++        ++ KV  +P +   T NNDI L
Sbjct: 326 EWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIAL 385

Query: 124 LKLATPARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLSN 183
           +KL  P  F+  V  VCLP+         LC  +GWG T+    KT + L  A + L+  
Sbjct: 386 MKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATE-EKGKTSEVLNAAKVLLIET 444

Query: 184 AECKKSW--GRRITDVMICAG--ASGVSSCMGDSGGPLVCQKDGAWTLVGIVSWGSDTCS 239
             C   +     IT  MICAG     V SC GDSGGPLV  K+  W L+G  SWGS    
Sbjct: 445 QRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAK 504

Query: 240 TSSPGVYARVTKLIPWVQKILAAN 263
              PGVY  V     W+ + + A+
Sbjct: 505 AYRPGVYGNVMVFTDWIYRQMRAD 528


>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
           sapiens]
          Length = 492

 Score =  165 bits (418), Expect = 3e-41
 Identities = 97/264 (36%), Positives = 131/264 (49%), Gaps = 10/264 (3%)

Query: 8   SCFSLVGAAFGCGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQDKTGFHFCGGSLISE 67
           +C S    +  C    ++   S  SRIV GE A+PG+WPWQVSL  +   H CGGS+I+ 
Sbjct: 230 ACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQN-VHVCGGSIITP 288

Query: 68  DWVVTAAHCGVRTSDVVVAGEFDQGSDEENIQVL----KIAKVFKNPKFSILTVNNDITL 123
           +W+VTAAHC  +  +         G   ++        ++ KV  +P +   T NNDI L
Sbjct: 289 EWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIAL 348

Query: 124 LKLATPARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLSN 183
           +KL  P  F+  V  VCLP+         LC  +GWG T+    KT + L  A + L+  
Sbjct: 349 MKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATE-EKGKTSEVLNAAKVLLIET 407

Query: 184 AECKKSW--GRRITDVMICAG--ASGVSSCMGDSGGPLVCQKDGAWTLVGIVSWGSDTCS 239
             C   +     IT  MICAG     V SC GDSGGPLV  K+  W L+G  SWGS    
Sbjct: 408 QRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAK 467

Query: 240 TSSPGVYARVTKLIPWVQKILAAN 263
              PGVY  V     W+ + + A+
Sbjct: 468 AYRPGVYGNVMVFTDWIYRQMRAD 491


>gi|13775595 tryptase alpha/beta 1 precursor [Homo sapiens]
          Length = 275

 Score =  165 bits (418), Expect = 3e-41
 Identities = 98/272 (36%), Positives = 135/272 (49%), Gaps = 21/272 (7%)

Query: 1   MASLWLLSCFSLVGAAFGCGVPAIHPVLSGLSR--IVNGEDAVPGSWPWQVSLQDKTGF- 57
           M +L LL+   L   A+    P        L R  IV G++A    WPWQVSL+    + 
Sbjct: 1   MLNLLLLALPVLASRAYAAPAPG-----QALQRVGIVGGQEAPRSKWPWQVSLRVHGPYW 55

Query: 58  -HFCGGSLISEDWVVTAAHC-GVRTSDVVVAG-EFDQGSDEENIQVLKIAKVFKNPKFSI 114
            HFCGGSLI   WV+TAAHC G    D+     +  +       Q+L ++++  +P+F  
Sbjct: 56  MHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYT 115

Query: 115 LTVNNDITLLKLATPARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPD-KL 173
             +  DI LL+L  P   S  V  V LP A + FP G  C  TGWG    +    P   L
Sbjct: 116 AQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPL 175

Query: 174 QQAALPLLSNAECKKSWG---------RRITDVMICAGASGVSSCMGDSGGPLVCQKDGA 224
           +Q  +P++ N  C   +          R + D M+CAG +   SC GDSGGPLVC+ +G 
Sbjct: 176 KQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGT 235

Query: 225 WTLVGIVSWGSDTCSTSSPGVYARVTKLIPWV 256
           W   G+VSWG      + PG+Y RVT  + W+
Sbjct: 236 WLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWI 267


>gi|110815798 ovochymase 1 [Homo sapiens]
          Length = 1134

 Score =  162 bits (410), Expect = 3e-40
 Identities = 92/251 (36%), Positives = 140/251 (55%), Gaps = 15/251 (5%)

Query: 19  CGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQDKTGFHFCGGSLISEDWVVTAAHCGV 78
           CG+P   P      RI  GE+A P  WPWQV L+   G + CGG++I+  W++TAAHC  
Sbjct: 561 CGIPPFSPQWLS-RRIAGGEEACPHCWPWQVGLRF-LGDYQCGGAIINPVWILTAAHCVQ 618

Query: 79  RTSD----VVVAGEFDQGSDEENIQVLKIAKVFKNPKFSILTVNNDITLLKLATPARFSQ 134
             ++     ++AG+ D+   E   QV +   +  +  F+ L+ ++DI L++L++P  ++ 
Sbjct: 619 LKNNPLSWTIIAGDHDRNLKESTEQVRRAKHIIVHEDFNTLSYDSDIALIQLSSPLEYNS 678

Query: 135 TVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLSNAECKKSWGRR- 193
            V  VCLP + +   +  +CA TGWG    +      +LQQ  + +L    C+ ++    
Sbjct: 679 VVRPVCLPHSAEPLFSSEICAVTGWGSISADGG-LASRLQQIQVHVLEREVCEHTYYSAH 737

Query: 194 ---ITDVMICAG--ASGVSS-CMGDSGGPLVCQ-KDGAWTLVGIVSWGSDTCSTSSPGVY 246
              IT+ MICAG  ASG    C GDSGGPLVC+ ++G + L GIVSWG+       PGV+
Sbjct: 738 PGGITEKMICAGFAASGEKDFCQGDSGGPLVCRHENGPFVLYGIVSWGAGCVQPWKPGVF 797

Query: 247 ARVTKLIPWVQ 257
           ARV   + W+Q
Sbjct: 798 ARVMIFLDWIQ 808



 Score =  138 bits (348), Expect = 4e-33
 Identities = 87/253 (34%), Positives = 135/253 (53%), Gaps = 26/253 (10%)

Query: 32  SRIVNGEDAVPGSWPWQVSLQDKTGFHFCGGSLISEDWVVTAAHCGVRTSD------VVV 85
           SRI +  ++     PWQVSL+     HFCGGSLI ED VVTAAHC    S+       V 
Sbjct: 45  SRISSWRNSTVTGHPWQVSLKSDE-HHFCGGSLIQEDRVVTAAHCLDSLSEKQLKNITVT 103

Query: 86  AGEFDQGSDEENIQVLKIAKVFKNPKFSILT-VNNDITLLKLATPARFSQTVSAVCLPSA 144
           +GE+     ++  Q + ++K+  +P+++    ++ DI LL L    +F   V  +CLP +
Sbjct: 104 SGEYSLFQKDKQEQNIPVSKIITHPEYNSREYMSPDIALLYLKHKVKFGNAVQPICLPDS 163

Query: 145 DDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLSNAECK---KSWG-RRITDVMIC 200
           DD    G LC ++GWGK     ++  + LQ+  LP++ +  C    KS     +   M+C
Sbjct: 164 DDKVEPGILCLSSGWGKIS-KTSEYSNVLQEMELPIMDDRACNTVLKSMNLPPLGRTMLC 222

Query: 201 AGAS--GVSSCMGDSGGPLVCQKDGA-WTLVGIVSWGSDTCSTSSP----------GVYA 247
           AG    G+ +C GDSGGPLVC++ G  W L GI SW +     S P          G+++
Sbjct: 223 AGFPDWGMDACQGDSGGPLVCRRGGGIWILAGITSWVAGCAGGSVPVRNNHVKASLGIFS 282

Query: 248 RVTKLIPWVQKIL 260
           +V++L+ ++ + L
Sbjct: 283 KVSELMDFITQNL 295


>gi|11415040 matriptase [Homo sapiens]
          Length = 855

 Score =  162 bits (409), Expect = 4e-40
 Identities = 92/240 (38%), Positives = 126/240 (52%), Gaps = 14/240 (5%)

Query: 32  SRIVNGEDAVPGSWPWQVSLQDKTGFHFCGGSLISEDWVVTAAHC-----GVRTSD---- 82
           +R+V G DA  G WPWQVSL      H CG SLIS +W+V+AAHC     G R SD    
Sbjct: 613 ARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQW 672

Query: 83  VVVAGEFDQGS-DEENIQVLKIAKVFKNPKFSILTVNNDITLLKLATPARFSQTVSAVCL 141
               G  DQ       +Q  ++ ++  +P F+  T + DI LL+L  PA +S  V  +CL
Sbjct: 673 TAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICL 732

Query: 142 PSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLSNAECKKSWGRRITDVMICA 201
           P A   FPAG     TGWG T+Y        LQ+  + +++   C+    ++IT  M+C 
Sbjct: 733 PDASHVFPAGKAIWVTGWGHTQYGGTGAL-ILQKGEIRVINQTTCENLLPQQITPRMMCV 791

Query: 202 G--ASGVSSCMGDSGGPL-VCQKDGAWTLVGIVSWGSDTCSTSSPGVYARVTKLIPWVQK 258
           G  + GV SC GDSGGPL   + DG     G+VSWG      + PGVY R+     W+++
Sbjct: 792 GFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIKE 851


>gi|33695155 hepsin [Homo sapiens]
          Length = 417

 Score =  161 bits (407), Expect = 6e-40
 Identities = 95/244 (38%), Positives = 128/244 (52%), Gaps = 21/244 (8%)

Query: 31  LSRIVNGEDAVPGSWPWQVSLQDKTGFHFCGGSLISEDWVVTAAHCGVRTSDV-----VV 85
           + RIV G D   G WPWQVSL+   G H CGGSL+S DWV+TAAHC    + V     V 
Sbjct: 160 VDRIVGGRDTSLGRWPWQVSLR-YDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVF 218

Query: 86  AGEFDQGSDEENIQVLKIAKVFKNPKFSILTVN-----NDITLLKLATPARFSQTVSAVC 140
           AG   Q S    +Q+   A V+          N     NDI L+ L++P   ++ +  VC
Sbjct: 219 AGAVAQASPH-GLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVC 277

Query: 141 LPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLSNAECKKS--WGRRITDVM 198
           LP+A      G +C  TGWG T+Y   +    LQ+A +P++SN  C  +  +G +I   M
Sbjct: 278 LPAAGQALVDGKICTVTGWGNTQYYGQQA-GVLQEARVPIISNDVCNGADFYGNQIKPKM 336

Query: 199 ICAG--ASGVSSCMGDSGGPLVCQ----KDGAWTLVGIVSWGSDTCSTSSPGVYARVTKL 252
            CAG    G+ +C GDSGGP VC+    +   W L GIVSWG+       PGVY +V+  
Sbjct: 337 FCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDF 396

Query: 253 IPWV 256
             W+
Sbjct: 397 REWI 400


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.133    0.427 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,876,642
Number of Sequences: 37866
Number of extensions: 472411
Number of successful extensions: 1684
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 165
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 917
Number of HSP's gapped (non-prelim): 201
length of query: 263
length of database: 18,247,518
effective HSP length: 100
effective length of query: 163
effective length of database: 14,460,918
effective search space: 2357129634
effective search space used: 2357129634
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.