Search of human proteins with 117938734

Search of human proteins with 117938734

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|117938734 constitutive androstane receptor isoform 5 [Homo
sapiens]
         (309 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|117938734 constitutive androstane receptor isoform 5 [Homo sa...   627   e-180
gi|117938754 constitutive androstane receptor isoform 4 [Homo sa...   620   e-178
gi|4826661 constitutive androstane receptor isoform 3 [Homo sapi...   607   e-174
gi|117938752 constitutive androstane receptor isoform 2 [Homo sa...   606   e-174
gi|117938756 constitutive androstane receptor isoform 1 [Homo sa...   604   e-173
gi|117938732 constitutive androstane receptor isoform 11 [Homo s...   550   e-157
gi|117938740 constitutive androstane receptor isoform 8 [Homo sa...   546   e-155
gi|117938750 constitutive androstane receptor isoform 10 [Homo s...   531   e-151
gi|117938736 constitutive androstane receptor isoform 9 [Homo sa...   529   e-150
gi|117938746 constitutive androstane receptor isoform 7 [Homo sa...   525   e-149
gi|117938729 constitutive androstane receptor isoform 6 [Homo sa...   525   e-149
gi|117938742 constitutive androstane receptor isoform 15 [Homo s...   469   e-132
gi|117938748 constitutive androstane receptor isoform 14 [Homo s...   450   e-127
gi|117938744 constitutive androstane receptor isoform 13 [Homo s...   448   e-126
gi|117938738 constitutive androstane receptor isoform 12 [Homo s...   446   e-126
gi|14702164 nuclear receptor subfamily 1, group I, member 2 isof...   244   7e-65
gi|11863132 nuclear receptor subfamily 1, group I, member 2 isof...   233   2e-61
gi|34398348 nuclear receptor subfamily 1, group I, member 2 isof...   233   2e-61
gi|189491771 thyroid hormone receptor, beta [Homo sapiens]            145   4e-35
gi|189491769 thyroid hormone receptor, beta [Homo sapiens]            145   4e-35
gi|40806162 thyroid hormone receptor, beta [Homo sapiens]             145   4e-35
gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo ...   139   3e-33
gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo s...   139   3e-33
gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo sapi...   137   9e-33
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso...   136   3e-32
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso...   136   3e-32
gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo sapi...   134   8e-32
gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo...   127   1e-29
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]   127   2e-29
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]    127   2e-29

>gi|117938734 constitutive androstane receptor isoform 5 [Homo
           sapiens]
          Length = 309

 Score =  627 bits (1616), Expect = e-180
 Identities = 309/309 (100%), Positives = 309/309 (100%)

Query: 1   MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR 60
           MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR
Sbjct: 1   MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR 60

Query: 61  RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA 120
           RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA
Sbjct: 61  RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA 120

Query: 121 HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP 180
           HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP
Sbjct: 121 HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP 180

Query: 181 VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARDRPGVTQRD 240
           VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARDRPGVTQRD
Sbjct: 181 VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARDRPGVTQRD 240

Query: 241 EIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAM 300
           EIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAM
Sbjct: 241 EIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAM 300

Query: 301 MPLLQEICS 309
           MPLLQEICS
Sbjct: 301 MPLLQEICS 309


>gi|117938754 constitutive androstane receptor isoform 4 [Homo
           sapiens]
          Length = 314

 Score =  620 bits (1600), Expect = e-178
 Identities = 309/314 (98%), Positives = 309/314 (98%), Gaps = 5/314 (1%)

Query: 1   MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR 60
           MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR
Sbjct: 1   MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR 60

Query: 61  RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA 120
           RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA
Sbjct: 61  RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA 120

Query: 121 HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP 180
           HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP
Sbjct: 121 HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP 180

Query: 181 VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGAR-----DRPG 235
           VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGAR     DRPG
Sbjct: 181 VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARAPYLTDRPG 240

Query: 236 VTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQ 295
           VTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQ
Sbjct: 241 VTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQ 300

Query: 296 GLSAMMPLLQEICS 309
           GLSAMMPLLQEICS
Sbjct: 301 GLSAMMPLLQEICS 314


>gi|4826661 constitutive androstane receptor isoform 3 [Homo
           sapiens]
          Length = 348

 Score =  607 bits (1566), Expect = e-174
 Identities = 309/348 (88%), Positives = 309/348 (88%), Gaps = 39/348 (11%)

Query: 1   MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR 60
           MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR
Sbjct: 1   MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR 60

Query: 61  RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA 120
           RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA
Sbjct: 61  RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA 120

Query: 121 HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP 180
           HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP
Sbjct: 121 HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP 180

Query: 181 VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGAR--------- 231
           VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGAR         
Sbjct: 181 VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVGFQVEFLE 240

Query: 232 ------------------------------DRPGVTQRDEIDQLQEEMALTLQSYIKGQQ 261
                                         DRPGVTQRDEIDQLQEEMALTLQSYIKGQQ
Sbjct: 241 LLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQ 300

Query: 262 RRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS 309
           RRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS
Sbjct: 301 RRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS 348


>gi|117938752 constitutive androstane receptor isoform 2 [Homo
           sapiens]
          Length = 352

 Score =  606 bits (1562), Expect = e-174
 Identities = 309/352 (87%), Positives = 309/352 (87%), Gaps = 43/352 (12%)

Query: 1   MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR 60
           MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR
Sbjct: 1   MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR 60

Query: 61  RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA 120
           RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA
Sbjct: 61  RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA 120

Query: 121 HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP 180
           HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP
Sbjct: 121 HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP 180

Query: 181 VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGAR--------- 231
           VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGAR         
Sbjct: 181 VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVSPTVGFQV 240

Query: 232 ----------------------------------DRPGVTQRDEIDQLQEEMALTLQSYI 257
                                             DRPGVTQRDEIDQLQEEMALTLQSYI
Sbjct: 241 EFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYI 300

Query: 258 KGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS 309
           KGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS
Sbjct: 301 KGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS 352


>gi|117938756 constitutive androstane receptor isoform 1 [Homo
           sapiens]
          Length = 357

 Score =  604 bits (1557), Expect = e-173
 Identities = 309/357 (86%), Positives = 309/357 (86%), Gaps = 48/357 (13%)

Query: 1   MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR 60
           MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR
Sbjct: 1   MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR 60

Query: 61  RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA 120
           RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA
Sbjct: 61  RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA 120

Query: 121 HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP 180
           HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP
Sbjct: 121 HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP 180

Query: 181 VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGAR--------- 231
           VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGAR         
Sbjct: 181 VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVSPTVGFQV 240

Query: 232 ---------------------------------------DRPGVTQRDEIDQLQEEMALT 252
                                                  DRPGVTQRDEIDQLQEEMALT
Sbjct: 241 EFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLTDRPGVTQRDEIDQLQEEMALT 300

Query: 253 LQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS 309
           LQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS
Sbjct: 301 LQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS 357


>gi|117938732 constitutive androstane receptor isoform 11 [Homo
           sapiens]
          Length = 280

 Score =  550 bits (1417), Expect = e-157
 Identities = 274/274 (100%), Positives = 274/274 (100%)

Query: 36  RRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQA 95
           RRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQA
Sbjct: 7   RRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQA 66

Query: 96  QRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVL 155
           QRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVL
Sbjct: 67  QRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVL 126

Query: 156 PLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQ 215
           PLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQ
Sbjct: 127 PLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQ 186

Query: 216 NFLCGPLRYTIEDGARDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLG 275
           NFLCGPLRYTIEDGARDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLG
Sbjct: 187 NFLCGPLRYTIEDGARDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLG 246

Query: 276 LLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS 309
           LLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS
Sbjct: 247 LLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS 280


>gi|117938740 constitutive androstane receptor isoform 8 [Homo
           sapiens]
          Length = 296

 Score =  546 bits (1406), Expect = e-155
 Identities = 267/267 (100%), Positives = 267/267 (100%)

Query: 1   MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR 60
           MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR
Sbjct: 1   MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR 60

Query: 61  RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA 120
           RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA
Sbjct: 61  RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA 120

Query: 121 HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP 180
           HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP
Sbjct: 121 HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP 180

Query: 181 VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARDRPGVTQRD 240
           VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARDRPGVTQRD
Sbjct: 181 VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARDRPGVTQRD 240

Query: 241 EIDQLQEEMALTLQSYIKGQQRRPRDR 267
           EIDQLQEEMALTLQSYIKGQQRRPRDR
Sbjct: 241 EIDQLQEEMALTLQSYIKGQQRRPRDR 267


>gi|117938750 constitutive androstane receptor isoform 10 [Homo
           sapiens]
          Length = 319

 Score =  531 bits (1367), Expect = e-151
 Identities = 274/313 (87%), Positives = 274/313 (87%), Gaps = 39/313 (12%)

Query: 36  RRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQA 95
           RRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQA
Sbjct: 7   RRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQA 66

Query: 96  QRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVL 155
           QRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVL
Sbjct: 67  QRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVL 126

Query: 156 PLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQ 215
           PLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQ
Sbjct: 127 PLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQ 186

Query: 216 NFLCGPLRYTIEDGAR---------------------------------------DRPGV 236
           NFLCGPLRYTIEDGAR                                       DRPGV
Sbjct: 187 NFLCGPLRYTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGV 246

Query: 237 TQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQG 296
           TQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQG
Sbjct: 247 TQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQG 306

Query: 297 LSAMMPLLQEICS 309
           LSAMMPLLQEICS
Sbjct: 307 LSAMMPLLQEICS 319


>gi|117938736 constitutive androstane receptor isoform 9 [Homo
           sapiens]
          Length = 324

 Score =  529 bits (1362), Expect = e-150
 Identities = 274/318 (86%), Positives = 274/318 (86%), Gaps = 44/318 (13%)

Query: 36  RRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQA 95
           RRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQA
Sbjct: 7   RRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQA 66

Query: 96  QRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVL 155
           QRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVL
Sbjct: 67  QRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVL 126

Query: 156 PLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQ 215
           PLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQ
Sbjct: 127 PLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQ 186

Query: 216 NFLCGPLRYTIEDGAR-------------------------------------------- 231
           NFLCGPLRYTIEDGAR                                            
Sbjct: 187 NFLCGPLRYTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLT 246

Query: 232 DRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQI 291
           DRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQI
Sbjct: 247 DRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQI 306

Query: 292 QHIQGLSAMMPLLQEICS 309
           QHIQGLSAMMPLLQEICS
Sbjct: 307 QHIQGLSAMMPLLQEICS 324


>gi|117938746 constitutive androstane receptor isoform 7 [Homo
           sapiens]
          Length = 339

 Score =  525 bits (1352), Expect = e-149
 Identities = 267/310 (86%), Positives = 267/310 (86%), Gaps = 43/310 (13%)

Query: 1   MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR 60
           MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR
Sbjct: 1   MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR 60

Query: 61  RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA 120
           RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA
Sbjct: 61  RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA 120

Query: 121 HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP 180
           HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP
Sbjct: 121 HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP 180

Query: 181 VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGAR--------- 231
           VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGAR         
Sbjct: 181 VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVSPTVGFQV 240

Query: 232 ----------------------------------DRPGVTQRDEIDQLQEEMALTLQSYI 257
                                             DRPGVTQRDEIDQLQEEMALTLQSYI
Sbjct: 241 EFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYI 300

Query: 258 KGQQRRPRDR 267
           KGQQRRPRDR
Sbjct: 301 KGQQRRPRDR 310


>gi|117938729 constitutive androstane receptor isoform 6 [Homo
           sapiens]
          Length = 340

 Score =  525 bits (1351), Expect = e-149
 Identities = 267/311 (85%), Positives = 267/311 (85%), Gaps = 44/311 (14%)

Query: 1   MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR 60
           MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR
Sbjct: 1   MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR 60

Query: 61  RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA 120
           RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA
Sbjct: 61  RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA 120

Query: 121 HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP 180
           HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP
Sbjct: 121 HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP 180

Query: 181 VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGAR--------- 231
           VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGAR         
Sbjct: 181 VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVGFQVEFLE 240

Query: 232 -----------------------------------DRPGVTQRDEIDQLQEEMALTLQSY 256
                                              DRPGVTQRDEIDQLQEEMALTLQSY
Sbjct: 241 LLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLTDRPGVTQRDEIDQLQEEMALTLQSY 300

Query: 257 IKGQQRRPRDR 267
           IKGQQRRPRDR
Sbjct: 301 IKGQQRRPRDR 311


>gi|117938742 constitutive androstane receptor isoform 15 [Homo
           sapiens]
          Length = 267

 Score =  469 bits (1207), Expect = e-132
 Identities = 232/232 (100%), Positives = 232/232 (100%)

Query: 36  RRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQA 95
           RRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQA
Sbjct: 7   RRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQA 66

Query: 96  QRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVL 155
           QRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVL
Sbjct: 67  QRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVL 126

Query: 156 PLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQ 215
           PLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQ
Sbjct: 127 PLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQ 186

Query: 216 NFLCGPLRYTIEDGARDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDR 267
           NFLCGPLRYTIEDGARDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDR
Sbjct: 187 NFLCGPLRYTIEDGARDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDR 238


>gi|117938748 constitutive androstane receptor isoform 14 [Homo
           sapiens]
          Length = 306

 Score =  450 bits (1157), Expect = e-127
 Identities = 232/271 (85%), Positives = 232/271 (85%), Gaps = 39/271 (14%)

Query: 36  RRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQA 95
           RRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQA
Sbjct: 7   RRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQA 66

Query: 96  QRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVL 155
           QRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVL
Sbjct: 67  QRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVL 126

Query: 156 PLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQ 215
           PLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQ
Sbjct: 127 PLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQ 186

Query: 216 NFLCGPLRYTIEDGAR---------------------------------------DRPGV 236
           NFLCGPLRYTIEDGAR                                       DRPGV
Sbjct: 187 NFLCGPLRYTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGV 246

Query: 237 TQRDEIDQLQEEMALTLQSYIKGQQRRPRDR 267
           TQRDEIDQLQEEMALTLQSYIKGQQRRPRDR
Sbjct: 247 TQRDEIDQLQEEMALTLQSYIKGQQRRPRDR 277


>gi|117938744 constitutive androstane receptor isoform 13 [Homo
           sapiens]
          Length = 311

 Score =  448 bits (1152), Expect = e-126
 Identities = 232/276 (84%), Positives = 232/276 (84%), Gaps = 44/276 (15%)

Query: 36  RRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQA 95
           RRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQA
Sbjct: 7   RRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQA 66

Query: 96  QRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVL 155
           QRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVL
Sbjct: 67  QRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVL 126

Query: 156 PLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQ 215
           PLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQ
Sbjct: 127 PLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQ 186

Query: 216 NFLCGPLRYTIEDGAR-------------------------------------------- 231
           NFLCGPLRYTIEDGAR                                            
Sbjct: 187 NFLCGPLRYTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLT 246

Query: 232 DRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDR 267
           DRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDR
Sbjct: 247 DRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDR 282


>gi|117938738 constitutive androstane receptor isoform 12 [Homo
           sapiens]
          Length = 315

 Score =  446 bits (1148), Expect = e-126
 Identities = 232/280 (82%), Positives = 232/280 (82%), Gaps = 48/280 (17%)

Query: 36  RRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQA 95
           RRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQA
Sbjct: 7   RRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQA 66

Query: 96  QRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVL 155
           QRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVL
Sbjct: 67  QRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVL 126

Query: 156 PLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQ 215
           PLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQ
Sbjct: 127 PLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQ 186

Query: 216 NFLCGPLRYTIEDGAR-------------------------------------------- 231
           NFLCGPLRYTIEDGAR                                            
Sbjct: 187 NFLCGPLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPA 246

Query: 232 ----DRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDR 267
               DRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDR
Sbjct: 247 PYLTDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDR 286


>gi|14702164 nuclear receptor subfamily 1, group I, member 2 isoform
           3 [Homo sapiens]
          Length = 397

 Score =  244 bits (623), Expect = 7e-65
 Identities = 139/351 (39%), Positives = 196/351 (55%), Gaps = 54/351 (15%)

Query: 11  CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQ 69
           C VCGD+ATGYHFN +TCEGCKGFFRR + ++    CPF  G+CE+++  RR C ACRL+
Sbjct: 41  CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLR 100

Query: 70  KCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQ------LSKEQEELIRTLLGAHTR 123
           KCL++GM+K+MI+S EA+  RRA   ++++++T  Q      L++EQ  +IR L+ A  +
Sbjct: 101 KCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMK 160

Query: 124 HMGTMFEQFVQFRPPAHLFIHHQPLPTLAP--------VLPLVTHFADINTFMVLQVIKF 175
              T F  F  FR    L      +    P        +  L+ H AD++T+M   +I F
Sbjct: 161 TFDTTFSHFKNFRVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISF 220

Query: 176 TKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGA----- 230
            K +  FR LPIEDQISLLKGAA E+C +  NT F  +T  + CG L Y +ED A     
Sbjct: 221 AKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQ 280

Query: 231 ---------------------------------RDRPGVTQRDEIDQLQEEMALTLQSYI 257
                                             DRPGV Q   +DQLQE+ A+TL+SYI
Sbjct: 281 LLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYI 340

Query: 258 KGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAM-MPLLQEI 307
           +  + +P  RFL+ K++ +L ELRSIN  +  ++  IQ +     PL+QE+
Sbjct: 341 ECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQEL 391


>gi|11863132 nuclear receptor subfamily 1, group I, member 2 isoform
           2 [Homo sapiens]
          Length = 473

 Score =  233 bits (593), Expect = 2e-61
 Identities = 142/388 (36%), Positives = 199/388 (51%), Gaps = 91/388 (23%)

Query: 11  CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPF-AGSCEVSKTQRRHCPACRLQ 69
           C VCGD+ATGYHFN +TCEGCKGFFRR + ++    CPF  G+CE+++  RR C ACRL+
Sbjct: 80  CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLR 139

Query: 70  KCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQ------LSKEQEELIRTLLGAHTR 123
           KCL++GM+K+MI+S EA+  RRA   ++++++T  Q      L++EQ  +IR L+ A  +
Sbjct: 140 KCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMK 199

Query: 124 HMGTMFEQFVQFRPPAHLFIHHQ-PLPTLAP----------------------------- 153
              T F  F  FR P  L    + P    AP                             
Sbjct: 200 TFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDG 259

Query: 154 ---------------VLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAA 198
                          +  L+ H AD++T+M   +I F K +  FR LPIEDQISLLKGAA
Sbjct: 260 SVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAA 319

Query: 199 VEICHIVLNTTFCLQTQNFLCGPLRYTIEDGA---------------------------- 230
            E+C +  NT F  +T  + CG L Y +ED A                            
Sbjct: 320 FELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEY 379

Query: 231 ----------RDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAEL 280
                      DRPGV Q   +DQLQE+ A+TL+SYI+  + +P  RFL+ K++ +L EL
Sbjct: 380 VLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTEL 439

Query: 281 RSINEAYGYQIQHIQGLSAM-MPLLQEI 307
           RSIN  +  ++  IQ +     PL+QE+
Sbjct: 440 RSINAQHTQRLLRIQDIHPFATPLMQEL 467


>gi|34398348 nuclear receptor subfamily 1, group I, member 2 isoform
           1 [Homo sapiens]
          Length = 434

 Score =  233 bits (593), Expect = 2e-61
 Identities = 142/388 (36%), Positives = 199/388 (51%), Gaps = 91/388 (23%)

Query: 11  CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPF-AGSCEVSKTQRRHCPACRLQ 69
           C VCGD+ATGYHFN +TCEGCKGFFRR + ++    CPF  G+CE+++  RR C ACRL+
Sbjct: 41  CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLR 100

Query: 70  KCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQ------LSKEQEELIRTLLGAHTR 123
           KCL++GM+K+MI+S EA+  RRA   ++++++T  Q      L++EQ  +IR L+ A  +
Sbjct: 101 KCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMK 160

Query: 124 HMGTMFEQFVQFRPPAHLFIHHQ-PLPTLAP----------------------------- 153
              T F  F  FR P  L    + P    AP                             
Sbjct: 161 TFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDG 220

Query: 154 ---------------VLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAA 198
                          +  L+ H AD++T+M   +I F K +  FR LPIEDQISLLKGAA
Sbjct: 221 SVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAA 280

Query: 199 VEICHIVLNTTFCLQTQNFLCGPLRYTIEDGA---------------------------- 230
            E+C +  NT F  +T  + CG L Y +ED A                            
Sbjct: 281 FELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEY 340

Query: 231 ----------RDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAEL 280
                      DRPGV Q   +DQLQE+ A+TL+SYI+  + +P  RFL+ K++ +L EL
Sbjct: 341 VLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTEL 400

Query: 281 RSINEAYGYQIQHIQGLSAM-MPLLQEI 307
           RSIN  +  ++  IQ +     PL+QE+
Sbjct: 401 RSINAQHTQRLLRIQDIHPFATPLMQEL 428


>gi|189491771 thyroid hormone receptor, beta [Homo sapiens]
          Length = 461

 Score =  145 bits (366), Expect = 4e-35
 Identities = 107/349 (30%), Positives = 160/349 (45%), Gaps = 66/349 (18%)

Query: 5   EDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGP--TCPFAGSCEVSKTQRRH 62
           +DEL  CVVCGD+ATGYH+  +TCEGCKGFFRRT+ K++ P  +C + G C + K  R  
Sbjct: 103 KDEL--CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQ 160

Query: 63  CPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSK----------EQEE 112
           C  CR +KC+  GM  D++L       +R    + R ++   +L K          E+ E
Sbjct: 161 CQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWE 220

Query: 113 LIRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPV-----LPLVTHFADIN 165
           LI+T+  AH  T   G+ ++Q  +F P     I   P+   AP      L   +HF  I 
Sbjct: 221 LIKTVTEAHVATNAQGSHWKQKRKFLPED---IGQAPIVN-APEGGKVDLEAFSHFTKII 276

Query: 166 TFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICH-------------IVLNTTFCL 212
           T  + +V+ F K LP+F  LP EDQI LLKG  +EI               + LN    +
Sbjct: 277 TPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAV 336

Query: 213 QTQNFLCGPL---------------RYTIEDG-----------ARDRPGVTQRDEIDQLQ 246
                  G L                + ++D            + DRPG+   + I++ Q
Sbjct: 337 TRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQ 396

Query: 247 EEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQ 295
           +   L  + YI    R+      + KLL  + +LR I   +  +  H++
Sbjct: 397 DSFLLAFEHYI--NYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMK 443


>gi|189491769 thyroid hormone receptor, beta [Homo sapiens]
          Length = 461

 Score =  145 bits (366), Expect = 4e-35
 Identities = 107/349 (30%), Positives = 160/349 (45%), Gaps = 66/349 (18%)

Query: 5   EDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGP--TCPFAGSCEVSKTQRRH 62
           +DEL  CVVCGD+ATGYH+  +TCEGCKGFFRRT+ K++ P  +C + G C + K  R  
Sbjct: 103 KDEL--CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQ 160

Query: 63  CPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSK----------EQEE 112
           C  CR +KC+  GM  D++L       +R    + R ++   +L K          E+ E
Sbjct: 161 CQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWE 220

Query: 113 LIRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPV-----LPLVTHFADIN 165
           LI+T+  AH  T   G+ ++Q  +F P     I   P+   AP      L   +HF  I 
Sbjct: 221 LIKTVTEAHVATNAQGSHWKQKRKFLPED---IGQAPIVN-APEGGKVDLEAFSHFTKII 276

Query: 166 TFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICH-------------IVLNTTFCL 212
           T  + +V+ F K LP+F  LP EDQI LLKG  +EI               + LN    +
Sbjct: 277 TPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAV 336

Query: 213 QTQNFLCGPL---------------RYTIEDG-----------ARDRPGVTQRDEIDQLQ 246
                  G L                + ++D            + DRPG+   + I++ Q
Sbjct: 337 TRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQ 396

Query: 247 EEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQ 295
           +   L  + YI    R+      + KLL  + +LR I   +  +  H++
Sbjct: 397 DSFLLAFEHYI--NYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMK 443


>gi|40806162 thyroid hormone receptor, beta [Homo sapiens]
          Length = 461

 Score =  145 bits (366), Expect = 4e-35
 Identities = 107/349 (30%), Positives = 160/349 (45%), Gaps = 66/349 (18%)

Query: 5   EDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGP--TCPFAGSCEVSKTQRRH 62
           +DEL  CVVCGD+ATGYH+  +TCEGCKGFFRRT+ K++ P  +C + G C + K  R  
Sbjct: 103 KDEL--CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQ 160

Query: 63  CPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSK----------EQEE 112
           C  CR +KC+  GM  D++L       +R    + R ++   +L K          E+ E
Sbjct: 161 CQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWE 220

Query: 113 LIRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPV-----LPLVTHFADIN 165
           LI+T+  AH  T   G+ ++Q  +F P     I   P+   AP      L   +HF  I 
Sbjct: 221 LIKTVTEAHVATNAQGSHWKQKRKFLPED---IGQAPIVN-APEGGKVDLEAFSHFTKII 276

Query: 166 TFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICH-------------IVLNTTFCL 212
           T  + +V+ F K LP+F  LP EDQI LLKG  +EI               + LN    +
Sbjct: 277 TPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAV 336

Query: 213 QTQNFLCGPL---------------RYTIEDG-----------ARDRPGVTQRDEIDQLQ 246
                  G L                + ++D            + DRPG+   + I++ Q
Sbjct: 337 TRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQ 396

Query: 247 EEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQ 295
           +   L  + YI    R+      + KLL  + +LR I   +  +  H++
Sbjct: 397 DSFLLAFEHYI--NYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMK 443


>gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
           sapiens]
          Length = 427

 Score =  139 bits (350), Expect = 3e-33
 Identities = 64/138 (46%), Positives = 90/138 (65%), Gaps = 5/138 (3%)

Query: 9   RNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRL 68
           R C VCGD+ATG+HFNA+TCEGCKGFFRR++ +    TCPF G C ++K  RRHC ACRL
Sbjct: 22  RICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRL 81

Query: 69  QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQT-----PVQLSKEQEELIRTLLGAHTR 123
           ++C+D GM K+ IL+ E +  +R    +R+ ++        +LS+EQ+ +I  LL AH +
Sbjct: 82  KRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHK 141

Query: 124 HMGTMFEQFVQFRPPAHL 141
                +  F QFRPP  +
Sbjct: 142 TYDPTYSDFCQFRPPVRV 159



 Score = 82.0 bits (201), Expect = 6e-16
 Identities = 52/177 (29%), Positives = 84/177 (47%), Gaps = 41/177 (23%)

Query: 155 LPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQT 214
           L ++ H AD+ ++ + +VI F K +P FR L  EDQI LLK +A+E+  +  N +F +  
Sbjct: 224 LSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDD 283

Query: 215 QNFLCG--PLRYTIEDGAR---------------------------------------DR 233
            ++ CG    +Y + D  +                                       DR
Sbjct: 284 MSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDR 343

Query: 234 PGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQ 290
           PGV     I+ +Q+ ++ TLQ+YI+ +   P    LYAK++  LA+LRS+NE +  Q
Sbjct: 344 PGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQ 400


>gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
           sapiens]
          Length = 427

 Score =  139 bits (350), Expect = 3e-33
 Identities = 64/138 (46%), Positives = 90/138 (65%), Gaps = 5/138 (3%)

Query: 9   RNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRL 68
           R C VCGD+ATG+HFNA+TCEGCKGFFRR++ +    TCPF G C ++K  RRHC ACRL
Sbjct: 22  RICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRL 81

Query: 69  QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQT-----PVQLSKEQEELIRTLLGAHTR 123
           ++C+D GM K+ IL+ E +  +R    +R+ ++        +LS+EQ+ +I  LL AH +
Sbjct: 82  KRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHK 141

Query: 124 HMGTMFEQFVQFRPPAHL 141
                +  F QFRPP  +
Sbjct: 142 TYDPTYSDFCQFRPPVRV 159



 Score = 82.0 bits (201), Expect = 6e-16
 Identities = 52/177 (29%), Positives = 84/177 (47%), Gaps = 41/177 (23%)

Query: 155 LPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQT 214
           L ++ H AD+ ++ + +VI F K +P FR L  EDQI LLK +A+E+  +  N +F +  
Sbjct: 224 LSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDD 283

Query: 215 QNFLCG--PLRYTIEDGAR---------------------------------------DR 233
            ++ CG    +Y + D  +                                       DR
Sbjct: 284 MSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDR 343

Query: 234 PGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQ 290
           PGV     I+ +Q+ ++ TLQ+YI+ +   P    LYAK++  LA+LRS+NE +  Q
Sbjct: 344 PGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQ 400


>gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo
           sapiens]
          Length = 410

 Score =  137 bits (346), Expect = 9e-33
 Identities = 101/347 (29%), Positives = 156/347 (44%), Gaps = 62/347 (17%)

Query: 6   DELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPT--CPFAGSCEVSKTQRRHC 63
           D+   CVVCGD+ATGYH+  +TCEGCKGFFRRT+ K++ PT  C +   C + K  R  C
Sbjct: 48  DKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQC 107

Query: 64  PACRLQKCLDAGMRKDMILS----------AEALALRRAKQAQRRAQQTPVQLSKEQEEL 113
             CR +KC+  GM  D++L            E    RR K+   R+ Q   + + E+ +L
Sbjct: 108 QLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDL 167

Query: 114 IRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAP----VLPLVTHFADINTF 167
           I     AH  T   G+ ++Q  +F P     I   P+ ++       L   + F  I T 
Sbjct: 168 IHIATEAHRSTNAQGSHWKQRRKFLPDD---IGQSPIVSMPDGDKVDLEAFSEFTKIITP 224

Query: 168 MVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICH-------------IVLNTTFCLQT 214
            + +V+ F K LP+F  LP EDQI LLKG  +EI               + L+    ++ 
Sbjct: 225 AITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKR 284

Query: 215 QNFLCGPL---------------RYTIEDG-----------ARDRPGVTQRDEIDQLQEE 248
           +    G L                + ++D            + DR G+   D+I++ QE 
Sbjct: 285 EQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEA 344

Query: 249 MALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQ 295
             L  + Y+    R+      + KLL  + +LR I   +  +  H++
Sbjct: 345 YLLAFEHYV--NHRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHMK 389


>gi|194294519 nuclear receptor subfamily 1, group H, member 3
           isoform c [Homo sapiens]
          Length = 402

 Score =  136 bits (342), Expect = 3e-32
 Identities = 100/352 (28%), Positives = 157/352 (44%), Gaps = 62/352 (17%)

Query: 11  CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQK 70
           C VCGD+A+G+H+N L+CEGCKGFFRR+V K     C   G C +    RR C  CRL+K
Sbjct: 53  CSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRK 112

Query: 71  CLDAGMRKDMILSAEALALRRAKQAQR----------RAQQTP---VQLSKEQEELIRTL 117
           C  AGMR++ +LS E + L++ K+ +           RA   P    QLS EQ  +I  L
Sbjct: 113 CRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKL 172

Query: 118 LGAHTRHMGTMFEQFVQFRP-PAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFT 176
           + A  +     F   ++  P P     H +             HF ++    V +++ F 
Sbjct: 173 VAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQ-----QRFAHFTELAIVSVQEIVDFA 227

Query: 177 KDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRYTIEDGAR---- 231
           K LP F  L  EDQI+LLK +A+E+  +  +  +   +++        Y  ED A+    
Sbjct: 228 KQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQ 287

Query: 232 -----------------------------------DRPGVTQRDEIDQLQEEMALTLQSY 256
                                              DRP V  + ++++LQ      L +Y
Sbjct: 288 VEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAY 347

Query: 257 IKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMM-PLLQEI 307
           +      P DR ++ ++L  L  LR+++  +  Q+  ++     + PLL EI
Sbjct: 348 V--SIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEI 397


>gi|194294517 nuclear receptor subfamily 1, group H, member 3
           isoform a [Homo sapiens]
          Length = 447

 Score =  136 bits (342), Expect = 3e-32
 Identities = 100/352 (28%), Positives = 157/352 (44%), Gaps = 62/352 (17%)

Query: 11  CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQK 70
           C VCGD+A+G+H+N L+CEGCKGFFRR+V K     C   G C +    RR C  CRL+K
Sbjct: 98  CSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRK 157

Query: 71  CLDAGMRKDMILSAEALALRRAKQAQR----------RAQQTP---VQLSKEQEELIRTL 117
           C  AGMR++ +LS E + L++ K+ +           RA   P    QLS EQ  +I  L
Sbjct: 158 CRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKL 217

Query: 118 LGAHTRHMGTMFEQFVQFRP-PAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFT 176
           + A  +     F   ++  P P     H +             HF ++    V +++ F 
Sbjct: 218 VAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQ-----QRFAHFTELAIVSVQEIVDFA 272

Query: 177 KDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRYTIEDGAR---- 231
           K LP F  L  EDQI+LLK +A+E+  +  +  +   +++        Y  ED A+    
Sbjct: 273 KQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQ 332

Query: 232 -----------------------------------DRPGVTQRDEIDQLQEEMALTLQSY 256
                                              DRP V  + ++++LQ      L +Y
Sbjct: 333 VEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAY 392

Query: 257 IKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMM-PLLQEI 307
           +      P DR ++ ++L  L  LR+++  +  Q+  ++     + PLL EI
Sbjct: 393 V--SIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEI 442


>gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo
           sapiens]
          Length = 490

 Score =  134 bits (338), Expect = 8e-32
 Identities = 80/214 (37%), Positives = 112/214 (52%), Gaps = 21/214 (9%)

Query: 6   DELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPT--CPFAGSCEVSKTQRRHC 63
           D+   CVVCGD+ATGYH+  +TCEGCKGFFRRT+ K++ PT  C +   C + K  R  C
Sbjct: 48  DKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQC 107

Query: 64  PACRLQKCLDAGMRKDMILS----------AEALALRRAKQAQRRAQQTPVQLSKEQEEL 113
             CR +KC+  GM  D++L            E    RR K+   R+ Q   + + E+ +L
Sbjct: 108 QLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDL 167

Query: 114 IRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAP----VLPLVTHFADINTF 167
           I     AH  T   G+ ++Q  +F P     I   P+ ++       L   + F  I T 
Sbjct: 168 IHIATEAHRSTNAQGSHWKQRRKFLPDD---IGQSPIVSMPDGDKVDLEAFSEFTKIITP 224

Query: 168 MVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEI 201
            + +V+ F K LP+F  LP EDQI LLKG  +EI
Sbjct: 225 AITRVVDFAKKLPMFSELPCEDQIILLKGCCMEI 258


>gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo
           sapiens]
          Length = 472

 Score =  127 bits (319), Expect = 1e-29
 Identities = 102/328 (31%), Positives = 155/328 (47%), Gaps = 56/328 (17%)

Query: 6   DELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPA 65
           DEL  CVVCGD+A+GYH+NALTCEGCKGFFRR+++K+    C   G+C +    RR C  
Sbjct: 124 DEL--CVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQE 181

Query: 66  CRLQKCLDAGMRKDMILS-AEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGAHTRH 124
           CRL+KC + GM  + +L+  +  + R  K  ++ A QT   ++++ E      + + T+ 
Sbjct: 182 CRLRKCKEMGMLAECLLTEIQCKSKRLRKNVKQHADQT---VNEDSEGRDLRQVTSTTKS 238

Query: 125 MGTMFEQFVQFRPPAHLFI---HHQPLPTLAPVLPLVTHFADINTFMVLQ---------V 172
                E     +   H  +   + Q +P       L   F+    F++L          +
Sbjct: 239 CREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVL 298

Query: 173 IKFTKDLPVFRSLPIEDQISLLKGAAVEICHI----VLNTTFCLQTQNFL---------- 218
           ++FTK LP F++L  EDQI+LLKG+AVE   +    + N        + L          
Sbjct: 299 VEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSGIS 358

Query: 219 -------------CGPLRYTIEDGA---------RDRPGVTQRDEIDQLQEEMALTLQSY 256
                         G L+ T E+ A          DR  +  R+ +++LQE +   LQ  
Sbjct: 359 DEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKL 418

Query: 257 IKGQQRRPRDRFLYAKLLGLLAELRSIN 284
            K  Q  P +   +A LLG L ELR+ N
Sbjct: 419 CKIHQ--PENPQHFACLLGRLTELRTFN 444


>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
          Length = 462

 Score =  127 bits (318), Expect = 2e-29
 Identities = 95/340 (27%), Positives = 156/340 (45%), Gaps = 57/340 (16%)

Query: 11  CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQK 70
           C VC D+++GYH+    CEGCKGFFRR++ K++  TC    +C ++K  R  C  CRLQK
Sbjct: 88  CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 147

Query: 71  CLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFE 130
           C + GM K+ + +      ++ K+  +        L+ E  ELI  +  AH        E
Sbjct: 148 CFEVGMSKESVRNDRN---KKKKEVPKPECSESYTLTPEVGELIEKVRKAHQ-------E 197

Query: 131 QFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQ 190
            F           ++     ++  + L   F++++T  +++ ++F K LP F +L I DQ
Sbjct: 198 TFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQ 257

Query: 191 ISLLKGAAVEICHIVLNTTFC----------------LQTQNFLCGPLRYTI-------- 226
           I+LLK A ++I  + + T +                  Q  N   GPL   +        
Sbjct: 258 ITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLL 317

Query: 227 -------EDG--------ARDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYA 271
                  E G          DR  + Q D +D LQE +   L+ Y++  +RRP    ++ 
Sbjct: 318 PLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVR--KRRPSRPHMFP 375

Query: 272 KLLGLLAELRSINEAYGYQI----QHIQGLSAMMPLLQEI 307
           K+L  + +LRSI+     ++      I G  +M PL+QE+
Sbjct: 376 KMLMKITDLRSISAKGAERVITLKMEIPG--SMPPLIQEM 413


>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
          Length = 457

 Score =  127 bits (318), Expect = 2e-29
 Identities = 95/340 (27%), Positives = 156/340 (45%), Gaps = 57/340 (16%)

Query: 11  CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQK 70
           C VC D+++GYH+    CEGCKGFFRR++ K++  TC    +C ++K  R  C  CRLQK
Sbjct: 83  CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 142

Query: 71  CLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFE 130
           C + GM K+ + +      ++ K+  +        L+ E  ELI  +  AH        E
Sbjct: 143 CFEVGMSKESVRNDRN---KKKKEVPKPECSESYTLTPEVGELIEKVRKAHQ-------E 192

Query: 131 QFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQ 190
            F           ++     ++  + L   F++++T  +++ ++F K LP F +L I DQ
Sbjct: 193 TFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQ 252

Query: 191 ISLLKGAAVEICHIVLNTTFC----------------LQTQNFLCGPLRYTI-------- 226
           I+LLK A ++I  + + T +                  Q  N   GPL   +        
Sbjct: 253 ITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLL 312

Query: 227 -------EDG--------ARDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYA 271
                  E G          DR  + Q D +D LQE +   L+ Y++  +RRP    ++ 
Sbjct: 313 PLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVR--KRRPSRPHMFP 370

Query: 272 KLLGLLAELRSINEAYGYQI----QHIQGLSAMMPLLQEI 307
           K+L  + +LRSI+     ++      I G  +M PL+QE+
Sbjct: 371 KMLMKITDLRSISAKGAERVITLKMEIPG--SMPPLIQEM 408


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.326    0.138    0.418 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,357,476
Number of Sequences: 37866
Number of extensions: 488643
Number of successful extensions: 2131
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 113
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 1830
Number of HSP's gapped (non-prelim): 244
length of query: 309
length of database: 18,247,518
effective HSP length: 102
effective length of query: 207
effective length of database: 14,385,186
effective search space: 2977733502
effective search space used: 2977733502
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.