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Search of human proteins with 10835197
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
sapiens]
(366 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 729 0.0
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap... 397 e-111
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 337 1e-92
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 322 3e-88
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 265 6e-71
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] 220 2e-57
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] 220 2e-57
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] 220 2e-57
gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens] 214 7e-56
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 211 6e-55
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 210 2e-54
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 210 2e-54
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 210 2e-54
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 210 2e-54
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 202 4e-52
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens] 191 9e-49
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] 190 2e-48
gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo sap... 183 2e-46
gi|4503383 dopamine receptor D1 [Homo sapiens] 182 3e-46
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] 181 7e-46
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] 176 2e-44
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens] 176 2e-44
gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo sa... 171 7e-43
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] 164 9e-41
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] 164 9e-41
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] 164 9e-41
gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens] 164 9e-41
gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens] 164 9e-41
gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens] 164 9e-41
gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens] 162 3e-40
>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
sapiens]
Length = 366
Score = 729 bits (1882), Expect = 0.0
Identities = 366/366 (100%), Positives = 366/366 (100%)
Query: 1 MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANY 60
MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANY
Sbjct: 1 MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANY 60
Query: 61 LICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALD 120
LICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALD
Sbjct: 61 LICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALD 120
Query: 121 RYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIV 180
RYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIV
Sbjct: 121 RYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIV 180
Query: 181 STIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKS 240
STIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKS
Sbjct: 181 STIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKS 240
Query: 241 VSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILG 300
VSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILG
Sbjct: 241 VSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILG 300
Query: 301 AFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQK 360
AFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQK
Sbjct: 301 AFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQK 360
Query: 361 LVRCRC 366
LVRCRC
Sbjct: 361 LVRCRC 366
>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
sapiens]
Length = 365
Score = 397 bits (1020), Expect = e-111
Identities = 207/362 (57%), Positives = 260/362 (71%), Gaps = 10/362 (2%)
Query: 10 NLTSEELLNRMPS----KILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSL 65
N T+E + P K+L+ +TL + +TT +N VI AI T+KLH PANYLICSL
Sbjct: 5 NCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSL 64
Query: 66 AVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAI 125
AVTD LVAVLVMP SI+YIV + W +G +C++WLSVD+TCCTCSILHL IALDRY AI
Sbjct: 65 AVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAI 124
Query: 126 TDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWR-HQGTS-RDDECIIKHDHIVSTI 183
T+A+EYARKRT K A +MI VW IS+FISMPPLFWR H+ S +C I+HDH++ TI
Sbjct: 125 TNAIEYARKRTAKRAALMILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHVIYTI 184
Query: 184 YSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVST 243
YST GAFYIPL LILILYY+IY AAK+LY KR +SR N ++ S K T
Sbjct: 185 YSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLS---NRSTDSQNSFASCKLTQT 241
Query: 244 SYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFV 303
V + S SDP+T+F+K H+++R + + RQ+IS TRERKAA LGLILGAF+
Sbjct: 242 FCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFI 301
Query: 304 ICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVR 363
+ WLPFF+KEL+V + +S E+++FL WLGY+NSLINPL+YT FNEDFK AF+KL+R
Sbjct: 302 LSWLPFFIKELIVGL-SIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIR 360
Query: 364 CR 365
CR
Sbjct: 361 CR 362
>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
sapiens]
Length = 390
Score = 337 bits (864), Expect = 1e-92
Identities = 175/368 (47%), Positives = 240/368 (65%), Gaps = 12/368 (3%)
Query: 5 NSSDQNLTSEELLNR----MPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANY 60
++ QN ++++ + + +P K+L+ + L+ + L TT N+ VIA + TRKLH PANY
Sbjct: 27 SAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANY 86
Query: 61 LICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALD 120
LI SLAVTD LV++LVMP S +Y V W +GQVVCD WLS DITCCT SILHL IALD
Sbjct: 87 LIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALD 146
Query: 121 RYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRD-DECIIKHDHI 179
RY AITDAVEY+ KRTPK A +MI +VW+ S+ IS+PP FWR + EC++ DHI
Sbjct: 147 RYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHI 206
Query: 180 VSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTK 239
+ T+YST GAFY P L++ LY +IY A++ K+ +R K Q++ +S ST
Sbjct: 207 LYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDS-PGSTS 265
Query: 240 SVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLIL 299
SV++ + + PS ++ +R + ++K+ RERKA TLG+IL
Sbjct: 266 SVTS--INSRVPDVPSESGSPVYVNQVKVRVS---DALLEKKKLMAARERKATKTLGIIL 320
Query: 300 GAFVICWLPFFVKELVVNVC-DKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAF 358
GAF++CWLPFF+ LV+ +C D C + +F WLGYLNSLINP+IYT+ NEDFK+AF
Sbjct: 321 GAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAF 380
Query: 359 QKLVRCRC 366
KL+R +C
Sbjct: 381 HKLIRFKC 388
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 322 bits (825), Expect = 3e-88
Identities = 174/345 (50%), Positives = 224/345 (64%), Gaps = 10/345 (2%)
Query: 23 KILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIV 82
KI +++ LS + L T N+ V+ I++TRKLH PANYLI SLA TD LV++LVMP SI
Sbjct: 38 KISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIA 97
Query: 83 YIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGI 142
Y + +W GQ++CDIWLS DITCCT SILHL IALDRY AITDA+EY+++RT HA
Sbjct: 98 YTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAT 157
Query: 143 MITIVWIISVFISMPPLFWRHQGTSRD-DECIIKHDHIVSTIYSTFGAFYIPLALILILY 201
MI IVW IS+ IS+PPLFWR + +C++ I TIYST GAFYIP L++ILY
Sbjct: 158 MIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILY 217
Query: 202 YKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKI 261
+IYRAA+ S K ++ S S S+++S S S S F
Sbjct: 218 GRIYRAARNRI-LNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFN- 275
Query: 262 HSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVC-D 320
H ++ S + R++IS RERKA LG+ILGAF+ICWLPFFV LV+ +C D
Sbjct: 276 HVKIKLADSALE------RKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRD 329
Query: 321 KCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCR 365
C I + +F WLGYLNSLINP+IYT+FNE+F++AFQK+V R
Sbjct: 330 SCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFR 374
>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
sapiens]
Length = 422
Score = 265 bits (676), Expect = 6e-71
Identities = 150/388 (38%), Positives = 224/388 (57%), Gaps = 50/388 (12%)
Query: 23 KILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIV 82
+++ SL L L N+ V+AAI + R L + ANYLI SLAVTD +V+VLV+P + +
Sbjct: 36 QVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAAL 95
Query: 83 YIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGI 142
Y V W +GQV CD+++++D+ CCT SILHL AIALDRY AITD ++Y KRTP+ A
Sbjct: 96 YQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAA 155
Query: 143 MITIVWIISVFISMPPLF-WR-HQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILIL 200
+I++ W+I IS+PP+ WR + S D C I DH TIYSTFGAFYIPL L+L+L
Sbjct: 156 LISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDH-GYTIYSTFGAFYIPLLLMLVL 214
Query: 201 YYKIYRAAK---------------TLYHKRQASRIAKEEVNGQVLLESGEKSTK------ 239
Y +I+RAA+ H + K+ VNG ESG ++ +
Sbjct: 215 YGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNG----ESGSRNWRLGVESK 270
Query: 240 ---SVSTSYVLEKSLSDPSTDFDKIHSTVRSLRS-----------------EFKHEKSWR 279
++ + + + + + ++H S E K+E++
Sbjct: 271 AGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAE 330
Query: 280 -RQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCD-KCKISEEMSNFLAWLGY 337
++K++ RERK TLG+I+G F++CWLPFF+ LV+ C+ C + + + WLGY
Sbjct: 331 AKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGY 390
Query: 338 LNSLINPLIYTIFNEDFKKAFQKLVRCR 365
NSL+NP+IY FN+DF+ AF+K+++C+
Sbjct: 391 SNSLLNPVIYAYFNKDFQNAFKKIIKCK 418
>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
Length = 432
Score = 220 bits (560), Expect = 2e-57
Identities = 129/349 (36%), Positives = 191/349 (54%), Gaps = 33/349 (9%)
Query: 23 KILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPF-SI 81
K+++ L+ + L+T N LV+ ++ +KL P+NYLI SLA+ D VAV VMPF S+
Sbjct: 81 KVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSV 140
Query: 82 VYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAG 141
++ WI G C++++++D+ CCT SI+ L I++DRY IT + Y ++ K
Sbjct: 141 TDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMA 200
Query: 142 IMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILY 201
MI VW++S I++PPLF Q + D C+I D TIYST AFYIP++++L +Y
Sbjct: 201 KMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQD-FGYTIYSTAVAFYIPMSVMLFMY 259
Query: 202 YKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKI 261
Y+IY+AA+ K + + E + + L K K V L + L
Sbjct: 260 YQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLL---------- 309
Query: 262 HSTVRSLRSEFKHEKSWRRQKIS-GTRERKAATTLGLILGAFVICWLPFFV----KELVV 316
KHE R+ IS RE+KAATTLG+I+GAF +CWLPFF+ + +
Sbjct: 310 -----------KHE----RKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFIC 354
Query: 317 NVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCR 365
C I + WLGY NSLINP IY FN D + ++ L++C+
Sbjct: 355 GTSCSC-IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQ 402
>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
Length = 479
Score = 220 bits (560), Expect = 2e-57
Identities = 129/349 (36%), Positives = 191/349 (54%), Gaps = 33/349 (9%)
Query: 23 KILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPF-SI 81
K+++ L+ + L+T N LV+ ++ +KL P+NYLI SLA+ D VAV VMPF S+
Sbjct: 81 KVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSV 140
Query: 82 VYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAG 141
++ WI G C++++++D+ CCT SI+ L I++DRY IT + Y ++ K
Sbjct: 141 TDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMA 200
Query: 142 IMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILY 201
MI VW++S I++PPLF Q + D C+I D TIYST AFYIP++++L +Y
Sbjct: 201 KMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQD-FGYTIYSTAVAFYIPMSVMLFMY 259
Query: 202 YKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKI 261
Y+IY+AA+ K + + E + + L K K V L + L
Sbjct: 260 YQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLL---------- 309
Query: 262 HSTVRSLRSEFKHEKSWRRQKIS-GTRERKAATTLGLILGAFVICWLPFFV----KELVV 316
KHE R+ IS RE+KAATTLG+I+GAF +CWLPFF+ + +
Sbjct: 310 -----------KHE----RKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFIC 354
Query: 317 NVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCR 365
C I + WLGY NSLINP IY FN D + ++ L++C+
Sbjct: 355 GTSCSC-IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQ 402
>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
Length = 445
Score = 220 bits (560), Expect = 2e-57
Identities = 129/349 (36%), Positives = 191/349 (54%), Gaps = 33/349 (9%)
Query: 23 KILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPF-SI 81
K+++ L+ + L+T N LV+ ++ +KL P+NYLI SLA+ D VAV VMPF S+
Sbjct: 81 KVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSV 140
Query: 82 VYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAG 141
++ WI G C++++++D+ CCT SI+ L I++DRY IT + Y ++ K
Sbjct: 141 TDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMA 200
Query: 142 IMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILY 201
MI VW++S I++PPLF Q + D C+I D TIYST AFYIP++++L +Y
Sbjct: 201 KMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQD-FGYTIYSTAVAFYIPMSVMLFMY 259
Query: 202 YKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKI 261
Y+IY+AA+ K + + E + + L K K V L + L
Sbjct: 260 YQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLL---------- 309
Query: 262 HSTVRSLRSEFKHEKSWRRQKIS-GTRERKAATTLGLILGAFVICWLPFFV----KELVV 316
KHE R+ IS RE+KAATTLG+I+GAF +CWLPFF+ + +
Sbjct: 310 -----------KHE----RKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFIC 354
Query: 317 NVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCR 365
C I + WLGY NSLINP IY FN D + ++ L++C+
Sbjct: 355 GTSCSC-IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQ 402
>gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]
Length = 357
Score = 214 bits (546), Expect = 7e-56
Identities = 122/340 (35%), Positives = 189/340 (55%), Gaps = 34/340 (10%)
Query: 24 ILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVY 83
+L+ L L T N LV+A I+ R H + L+ S+AV+D LVA LVMP S+V+
Sbjct: 41 VLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVH 100
Query: 84 -IVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGI 142
+ W +G+ +C +W++ D+ CCT SI +++AIALDRY +IT +EY + + +
Sbjct: 101 ELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNV 160
Query: 143 MITIVWIISVFISMPPLF--WRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILIL 200
MI + W +S IS+ PL W + +EC + + + ++ST GAFY+PL ++L +
Sbjct: 161 MIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYA-VFSTVGAFYLPLCVVLFV 219
Query: 201 YYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDK 260
Y+KIY+AAK R+ + N S +S + ++ S P F
Sbjct: 220 YWKIYKAAK--------FRVGSRKTN----------SVSPISEAVEVKDSAKQPQMVFTV 261
Query: 261 IHSTVRSLRSEFKHE-KSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVC 319
H+TV F+ E +WR QK E++AA +G+++G FV+CW+PFF+ EL+ +C
Sbjct: 262 RHATV-----TFQPEGDTWREQK-----EQRAALMVGILIGVFVLCWIPFFLTELISPLC 311
Query: 320 DKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQ 359
C I + WLGY NS NPLIYT FN+++ AF+
Sbjct: 312 -SCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFK 350
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 211 bits (538), Expect = 6e-55
Identities = 120/363 (33%), Positives = 195/363 (53%), Gaps = 25/363 (6%)
Query: 5 NSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICS 64
N + N T +L + I V L L L N LVI ++ R L P NY I +
Sbjct: 29 NQTSSNSTLPQL--DITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVN 86
Query: 65 LAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRA 124
LA+ D L++ V+PFS V W++G++ CDIW +VD+ CCT SIL L AI++DRY
Sbjct: 87 LAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIG 146
Query: 125 ITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLF-WRHQGTSRDDECIIKHDHIVSTI 183
+ +++Y T + A + + VW++S IS+ PL W+ + D EC + + + +
Sbjct: 147 VRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYA-L 205
Query: 184 YSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVST 243
+S+ G+FYIPLA+IL++Y ++Y AK +A + KE N + L T + +
Sbjct: 206 FSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG-VMKEMSNSKEL-------TLRIHS 257
Query: 244 SYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFV 303
E +LS S++ +F +RE+KAA TLG+++G F+
Sbjct: 258 KNFHEDTLSSTKAKGHNPRSSIAVKLFKF-------------SREKKAAKTLGIVVGMFI 304
Query: 304 ICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVR 363
+CWLPFF+ + ++ K + + + WLGY NS +NP+IY +++FK+AF +++
Sbjct: 305 LCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILG 364
Query: 364 CRC 366
C+C
Sbjct: 365 CQC 367
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 210 bits (534), Expect = 2e-54
Identities = 129/370 (34%), Positives = 194/370 (52%), Gaps = 39/370 (10%)
Query: 5 NSSDQ-NLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLIC 63
N+SD N T + IL+ + L GL L N LVI ++ R LH +Y I
Sbjct: 7 NASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIV 66
Query: 64 SLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYR 123
+LAV D L+ V+PFS ++ V W G+V C+IW +VD+ CCT SI+ L I++DRY
Sbjct: 67 NLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYI 126
Query: 124 AITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTI 183
++ + Y T + + + VW +S+ IS+ PLF Q D+ ++ +
Sbjct: 127 GVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVL 186
Query: 184 YSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVST 243
+S G+FY+PLA+IL++Y ++Y +AK E G L+SG K+ KS S
Sbjct: 187 FSALGSFYLPLAIILVMYCRVY-------------VVAKRESRG---LKSGLKTDKSDSE 230
Query: 244 SYVLE-------KSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLG 296
L S ++ K H +VR L+ +RE+KAA TLG
Sbjct: 231 QVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKF---------------SREKKAAKTLG 275
Query: 297 LILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKK 356
+++G FV+CWLPFF+ + + K SE + + WLGYLNS INP+IY +++FKK
Sbjct: 276 IVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKK 335
Query: 357 AFQKLVRCRC 366
AFQ ++R +C
Sbjct: 336 AFQNVLRIQC 345
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 210 bits (534), Expect = 2e-54
Identities = 129/370 (34%), Positives = 194/370 (52%), Gaps = 39/370 (10%)
Query: 5 NSSDQ-NLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLIC 63
N+SD N T + IL+ + L GL L N LVI ++ R LH +Y I
Sbjct: 7 NASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIV 66
Query: 64 SLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYR 123
+LAV D L+ V+PFS ++ V W G+V C+IW +VD+ CCT SI+ L I++DRY
Sbjct: 67 NLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYI 126
Query: 124 AITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTI 183
++ + Y T + + + VW +S+ IS+ PLF Q D+ ++ +
Sbjct: 127 GVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVL 186
Query: 184 YSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVST 243
+S G+FY+PLA+IL++Y ++Y +AK E G L+SG K+ KS S
Sbjct: 187 FSALGSFYLPLAIILVMYCRVY-------------VVAKRESRG---LKSGLKTDKSDSE 230
Query: 244 SYVLE-------KSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLG 296
L S ++ K H +VR L+ +RE+KAA TLG
Sbjct: 231 QVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKF---------------SREKKAAKTLG 275
Query: 297 LILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKK 356
+++G FV+CWLPFF+ + + K SE + + WLGYLNS INP+IY +++FKK
Sbjct: 276 IVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKK 335
Query: 357 AFQKLVRCRC 366
AFQ ++R +C
Sbjct: 336 AFQNVLRIQC 345
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 210 bits (534), Expect = 2e-54
Identities = 129/370 (34%), Positives = 194/370 (52%), Gaps = 39/370 (10%)
Query: 5 NSSDQ-NLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLIC 63
N+SD N T + IL+ + L GL L N LVI ++ R LH +Y I
Sbjct: 7 NASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIV 66
Query: 64 SLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYR 123
+LAV D L+ V+PFS ++ V W G+V C+IW +VD+ CCT SI+ L I++DRY
Sbjct: 67 NLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYI 126
Query: 124 AITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTI 183
++ + Y T + + + VW +S+ IS+ PLF Q D+ ++ +
Sbjct: 127 GVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVL 186
Query: 184 YSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVST 243
+S G+FY+PLA+IL++Y ++Y +AK E G L+SG K+ KS S
Sbjct: 187 FSALGSFYLPLAIILVMYCRVY-------------VVAKRESRG---LKSGLKTDKSDSE 230
Query: 244 SYVLE-------KSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLG 296
L S ++ K H +VR L+ +RE+KAA TLG
Sbjct: 231 QVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKF---------------SREKKAAKTLG 275
Query: 297 LILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKK 356
+++G FV+CWLPFF+ + + K SE + + WLGYLNS INP+IY +++FKK
Sbjct: 276 IVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKK 335
Query: 357 AFQKLVRCRC 366
AFQ ++R +C
Sbjct: 336 AFQNVLRIQC 345
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 210 bits (534), Expect = 2e-54
Identities = 129/370 (34%), Positives = 194/370 (52%), Gaps = 39/370 (10%)
Query: 5 NSSDQ-NLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLIC 63
N+SD N T + IL+ + L GL L N LVI ++ R LH +Y I
Sbjct: 7 NASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIV 66
Query: 64 SLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYR 123
+LAV D L+ V+PFS ++ V W G+V C+IW +VD+ CCT SI+ L I++DRY
Sbjct: 67 NLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYI 126
Query: 124 AITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTI 183
++ + Y T + + + VW +S+ IS+ PLF Q D+ ++ +
Sbjct: 127 GVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVL 186
Query: 184 YSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVST 243
+S G+FY+PLA+IL++Y ++Y +AK E G L+SG K+ KS S
Sbjct: 187 FSALGSFYLPLAIILVMYCRVY-------------VVAKRESRG---LKSGLKTDKSDSE 230
Query: 244 SYVLE-------KSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLG 296
L S ++ K H +VR L+ +RE+KAA TLG
Sbjct: 231 QVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKF---------------SREKKAAKTLG 275
Query: 297 LILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKK 356
+++G FV+CWLPFF+ + + K SE + + WLGYLNS INP+IY +++FKK
Sbjct: 276 IVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKK 335
Query: 357 AFQKLVRCRC 366
AFQ ++R +C
Sbjct: 336 AFQNVLRIQC 345
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 202 bits (514), Expect = 4e-52
Identities = 109/341 (31%), Positives = 180/341 (52%), Gaps = 18/341 (5%)
Query: 26 VSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIV 85
V + L+ LM N LVI ++ R L NY I +LAV D L++ V+PFS V
Sbjct: 99 VGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEV 158
Query: 86 RESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIT 145
W G+ CD+W +VD+ CCT SIL L I++DRY + +++Y T + A ++
Sbjct: 159 LGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILA 218
Query: 146 IVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIY 205
++W++++ +S+ PL + D+ + ++S+ +FY+P+A+I+++Y ++Y
Sbjct: 219 LLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVY 278
Query: 206 RAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTV 265
A++ LE+G K + ++ VL +T D H
Sbjct: 279 VVARSTTRS----------------LEAGVKRERGKASEVVLRIHCRGAATGADGAHGMR 322
Query: 266 RSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKIS 325
+ F+ S R K S RE+KAA TL +++G FV+CW PFF + ++ + K S
Sbjct: 323 SAKGHTFRSSLSVRLLKFS--REKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPS 380
Query: 326 EEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRC 366
E + + WLGY NS +NPLIY + +FK+AF +L+RC+C
Sbjct: 381 EGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQC 421
>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
Length = 414
Score = 191 bits (485), Expect = 9e-49
Identities = 125/369 (33%), Positives = 189/369 (51%), Gaps = 51/369 (13%)
Query: 41 NSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWL 100
N LV A+ + L NYLI SLAV D LVA LVMP+ + V W ++ CDI++
Sbjct: 52 NVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFV 111
Query: 101 SVDITCCTCSILHLSAIALDRYRAITDAVEY-ARKRTPKHAGIMITIVWIISVFISMPPL 159
++D+ CT SIL+L AI++DRY A+ + Y R + + +MI+IVW++S IS P L
Sbjct: 112 TLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLL 171
Query: 160 FWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIY----RAAKTLYHKR 215
F + + +ECII + V +YS+ +FY+P + L++Y KIY R K + KR
Sbjct: 172 FGLN--NADQNECIIANPAFV--VYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKR 227
Query: 216 --------------QASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKI 261
+A+R A +E+ ++L + S L+ P +
Sbjct: 228 SSRAFRAHLRAPLKEAARRA-QELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGL 286
Query: 262 HSTVRSLRSEFKHE--------------------------KSWRRQKISGTRERKAATTL 295
HST S K+ K+ R+K+S +E+KA L
Sbjct: 287 HSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQML 346
Query: 296 GLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFK 355
++LG F+ICWLPFF+ ++ CD C I + + WLGY+NS +NP+IYT FN +F+
Sbjct: 347 AIVLGVFIICWLPFFITHILNIHCD-CNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFR 405
Query: 356 KAFQKLVRC 364
KAF K++ C
Sbjct: 406 KAFLKILHC 414
>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
Length = 367
Score = 190 bits (483), Expect = 2e-48
Identities = 115/343 (33%), Positives = 182/343 (53%), Gaps = 13/343 (3%)
Query: 27 SLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVY--I 84
+L+ L L N LV A++ R L NYL+ SLAV D LVA LVMP+ +VY +
Sbjct: 33 ALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPW-VVYLEV 91
Query: 85 VRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYAR---KRTPKHAG 141
W ++ CD+++++D+ CT SIL+L AI++DRY A+ V Y + + +
Sbjct: 92 TGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVA 151
Query: 142 IMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILY 201
+MIT VW+++ +S P LF + T C I + V IYS+ +FY+P + +++Y
Sbjct: 152 LMITAVWVLAFAVSCPLLFGFNT-TGDPTVCSISNPDFV--IYSSVVSFYLPFGVTVLVY 208
Query: 202 YKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKI 261
+IY K KR +R + + + T S +++ K D
Sbjct: 209 ARIYVVLKQRRRKRILTR---QNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALG 265
Query: 262 HSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDK 321
+ E K E+ R + RE+KA + ++LGAF++CWLPFF+ ++ C
Sbjct: 266 GPGFQERGGELKREEK-TRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQT 324
Query: 322 CKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRC 364
C +S E+ + WLGY+NS +NP+IYT FN +F+KAF K++ C
Sbjct: 325 CHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367
>gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo
sapiens]
Length = 458
Score = 183 bits (464), Expect = 2e-46
Identities = 118/355 (33%), Positives = 195/355 (54%), Gaps = 43/355 (12%)
Query: 27 SLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVR 86
+L++ + +MT N LVI A+ + +KLH+ NY + SLA+ D LV +LVMP S++ I+
Sbjct: 57 ALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILY 116
Query: 87 ES-WIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIT 145
+ W + + +C +W+S+D+ T SI+HL AI+LDRY AI + +E++R + A + I
Sbjct: 117 DYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIA 176
Query: 146 IVWIISVFISMP-PLFWRHQGTSRDDE--------CIIKHDHIVSTIYSTFGAFYIPLAL 196
IVW IS+ +S+P P+ RD+E C++ + V + +F AF+IPL +
Sbjct: 177 IVWAISIGVSVPIPVI-----GLRDEEKVFVNNTTCVLNDPNFV--LIGSFVAFFIPLTI 229
Query: 197 ILILY----YKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLS 252
++I Y Y + R A L H EE G L K + E++ +
Sbjct: 230 MVITYCLTIYVLRRQALMLLHGH------TEEPPGLSL-----DFLKCCKRNTAEEENSA 278
Query: 253 DPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVK 312
+P+ D ++ R K E+ R + ERKA+ LG++ F+I W PFF+
Sbjct: 279 NPNQD--------QNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFIT 330
Query: 313 ELVVNVCDKC---KISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRC 364
++ +C+K K+ E++ N W+GY+ S INPL+YT+FN+ +++AF +RC
Sbjct: 331 NILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRC 385
>gi|4503383 dopamine receptor D1 [Homo sapiens]
Length = 446
Score = 182 bits (463), Expect = 3e-46
Identities = 138/385 (35%), Positives = 191/385 (49%), Gaps = 59/385 (15%)
Query: 1 MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPA-N 59
M LN+S + T + +IL + LS L L T N+LV AA+I R L N
Sbjct: 1 MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN 60
Query: 60 YLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIAL 119
+ + SLAV+D LVAVLVMP+ V + W G C+IW++ DI C T SIL+L I++
Sbjct: 61 FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSF-CNIWVAFDIMCSTASILNLCVISV 119
Query: 120 DRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPP--LFW-RHQGTSRDD------ 170
DRY AI+ Y RK TPK A I+I++ W +SV IS P L W + + TS D
Sbjct: 120 DRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSL 179
Query: 171 -ECIIKHDHIVSTIY---STFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVN 226
E I D +S Y S+ +FYIP+A++++ Y +IYR A ++Q RIA
Sbjct: 180 AETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIA-----QKQIRRIA----- 229
Query: 227 GQVLLESGEKSTKSVSTSYVLEKSL--SDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKIS 284
LE K+ T+ K + S P + F K+S
Sbjct: 230 ---ALERAAVHAKNCQTTTGNGKPVECSQPESSF-----------------------KMS 263
Query: 285 GTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCK-----ISEEMSNFLAWLGYLN 339
RE K TL +I+G FV CWLPFF+ ++ C + I + W G+ N
Sbjct: 264 FKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWAN 323
Query: 340 SLINPLIYTIFNEDFKKAFQKLVRC 364
S +NP+IY FN DF+KAF L+ C
Sbjct: 324 SSLNPIIYA-FNADFRKAFSTLLGC 347
>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
Length = 400
Score = 181 bits (460), Expect = 7e-46
Identities = 119/373 (31%), Positives = 184/373 (49%), Gaps = 40/373 (10%)
Query: 27 SLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVY--I 84
+L+ L L N LV A++ R L NYL+ SLAV D LVA LVMP+ +VY +
Sbjct: 33 ALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPW-VVYLEV 91
Query: 85 VRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYAR---KRTPKHAG 141
W ++ CD+++++D+ CT SIL+L AI++DRY A+ V Y + + +
Sbjct: 92 TGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVA 151
Query: 142 IMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILY 201
+MIT VW+++ +S P LF T C I + V IYS+ +FY+P + +++Y
Sbjct: 152 LMITAVWVLAFAVSCPLLF-GFNTTGDPTVCSISNPDFV--IYSSVVSFYLPFGVTVLVY 208
Query: 202 YKIYRAAKTLYHKRQASRIAKEEVNG-------QVLLESGEKSTKSVSTSYVLEKSLSDP 254
+IY K KR +R + N Q L S + +L P
Sbjct: 209 ARIYVVLKQRRRKRILTR-QNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGP 267
Query: 255 -----STDFDKIHSTVRSLRSEFKHEKSWRRQKISG------------------TRERKA 291
+ + T SL + S +K+S RE+KA
Sbjct: 268 GFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKA 327
Query: 292 ATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFN 351
+ ++LGAF++CWLPFF+ ++ C C +S E+ + WLGY+NS +NP+IYT FN
Sbjct: 328 TQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFN 387
Query: 352 EDFKKAFQKLVRC 364
+F+KAF K++ C
Sbjct: 388 IEFRKAFLKILSC 400
>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
Length = 397
Score = 176 bits (447), Expect = 2e-44
Identities = 110/355 (30%), Positives = 170/355 (47%), Gaps = 66/355 (18%)
Query: 17 LNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLV 76
L+ KI +++ L+ L L+T N +V A+ + R+L + N I SLA+TD L+ +LV
Sbjct: 12 LDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLV 71
Query: 77 MPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRT 136
+PFS +Y + W G+V C+I+ S+D+ CT SIL+L I+LDRY A+ D + Y T
Sbjct: 72 LPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVT 131
Query: 137 PKHAGIMITIVWIISVFISMPP--LFWRHQG-TSRDDECIIKHDHIVSTIYSTFG---AF 190
P I + ++W+IS+ +S L W + TS+ + K V+ +Y F
Sbjct: 132 PVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTF 191
Query: 191 YIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKS 250
Y+PL ++ I YY+I++ A+ QA RI
Sbjct: 192 YLPLLIMCITYYRIFKVARD-----QAKRI------------------------------ 216
Query: 251 LSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFF 310
H SW+ I RE KA TL ++GAF+ICW P+F
Sbjct: 217 ----------------------NHISSWKAATI---REHKATVTLAAVMGAFIICWFPYF 251
Query: 311 VKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCR 365
+ + I+E + + WLGY NS +NP++Y N DF+ +Q+L CR
Sbjct: 252 TAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCR 306
>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
Length = 359
Score = 176 bits (447), Expect = 2e-44
Identities = 110/355 (30%), Positives = 170/355 (47%), Gaps = 66/355 (18%)
Query: 17 LNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLV 76
L+ KI +++ L+ L L+T N +V A+ + R+L + N I SLA+TD L+ +LV
Sbjct: 12 LDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLV 71
Query: 77 MPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRT 136
+PFS +Y + W G+V C+I+ S+D+ CT SIL+L I+LDRY A+ D + Y T
Sbjct: 72 LPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVT 131
Query: 137 PKHAGIMITIVWIISVFISMPP--LFWRHQG-TSRDDECIIKHDHIVSTIYSTFG---AF 190
P I + ++W+IS+ +S L W + TS+ + K V+ +Y F
Sbjct: 132 PVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTF 191
Query: 191 YIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKS 250
Y+PL ++ I YY+I++ A+ QA RI
Sbjct: 192 YLPLLIMCITYYRIFKVARD-----QAKRI------------------------------ 216
Query: 251 LSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFF 310
H SW+ I RE KA TL ++GAF+ICW P+F
Sbjct: 217 ----------------------NHISSWKAATI---REHKATVTLAAVMGAFIICWFPYF 251
Query: 311 VKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCR 365
+ + I+E + + WLGY NS +NP++Y N DF+ +Q+L CR
Sbjct: 252 TAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCR 306
>gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo
sapiens]
Length = 471
Score = 171 bits (434), Expect = 7e-43
Identities = 105/346 (30%), Positives = 185/346 (53%), Gaps = 32/346 (9%)
Query: 27 SLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVR 86
+L + + ++T N LVI A+ + +KL + NY + SLA+ D L+ LVMP S++ I+
Sbjct: 78 ALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILY 137
Query: 87 E-SWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIT 145
W + +C +W+ +D+ T SI+HL AI+LDRY AI + + ++R + A + I
Sbjct: 138 GYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKII 197
Query: 146 IVWIISVFISMP-PLFWRHQGTS--RDDECIIKHDHIVSTIYSTFGAFYIPLALILILYY 202
VW ISV ISMP P+F + ++ C++ D+ V + +F +F+IPL +++I Y+
Sbjct: 198 AVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFV--LIGSFVSFFIPLTIMVITYF 255
Query: 203 KIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIH 262
T+ ++ + + ++ + K S S++ + SLS IH
Sbjct: 256 ------LTIKSLQKEATLCVSDLGTR---------AKLASFSFLPQSSLSSEKLFQRSIH 300
Query: 263 STVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVC-DK 321
S + RR S + E+KA LG++ FV+ W PFF+ ++ +C +
Sbjct: 301 REPGSY--------TGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKES 352
Query: 322 CK--ISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCR 365
C + + N W+GYL+S +NPL+YT+FN+ ++ AF + ++C+
Sbjct: 353 CNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQ 398
>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
Length = 359
Score = 164 bits (416), Expect = 9e-41
Identities = 119/377 (31%), Positives = 175/377 (46%), Gaps = 64/377 (16%)
Query: 4 LNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHH-PANYLI 62
++ D N++SEE + +L++ LS + LM N LV+ A+ R+L NY I
Sbjct: 1 MDKLDANVSSEEGFGSVEKVVLLTF-LSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFI 59
Query: 63 CSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRY 122
SLA D LV+VLVMPF + +V++ WI G+V C + S+D+ T SI HL I+LDRY
Sbjct: 60 VSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRY 119
Query: 123 RAI-TDAVEYARKRTPKHAGIMITIVWIISVFISMPPLF--WRHQG------------TS 167
AI + Y K TP +M+ W+I FIS P+ W + G S
Sbjct: 120 YAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNS 179
Query: 168 RDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNG 227
C+ + + S AFYIP L+++ YY+IY AK H Q + + +
Sbjct: 180 NSTYCVFMVNKPYAITCSVV-AFYIPFLLMVLAYYRIYVTAKE--HAHQIQMLQRAGASS 236
Query: 228 QVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTR 287
+ +S ++ HST R
Sbjct: 237 ESRPQSADQ-------------------------HSTHRM------------------RT 253
Query: 288 ERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIY 347
E KAA TL +I+G F +CW PFFV +V D + + FL WLGY+NS +NP +Y
Sbjct: 254 ETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFL-WLGYINSGLNPFLY 312
Query: 348 TIFNEDFKKAFQKLVRC 364
N+ F++AF ++ C
Sbjct: 313 AFLNKSFRRAFLIILCC 329
>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
Length = 428
Score = 164 bits (416), Expect = 9e-41
Identities = 119/377 (31%), Positives = 175/377 (46%), Gaps = 64/377 (16%)
Query: 4 LNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHH-PANYLI 62
++ D N++SEE + +L++ LS + LM N LV+ A+ R+L NY I
Sbjct: 1 MDKLDANVSSEEGFGSVEKVVLLTF-LSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFI 59
Query: 63 CSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRY 122
SLA D LV+VLVMPF + +V++ WI G+V C + S+D+ T SI HL I+LDRY
Sbjct: 60 VSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRY 119
Query: 123 RAI-TDAVEYARKRTPKHAGIMITIVWIISVFISMPPLF--WRHQG------------TS 167
AI + Y K TP +M+ W+I FIS P+ W + G S
Sbjct: 120 YAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNS 179
Query: 168 RDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNG 227
C+ + + S AFYIP L+++ YY+IY AK H Q + + +
Sbjct: 180 NSTYCVFMVNKPYAITCSVV-AFYIPFLLMVLAYYRIYVTAKE--HAHQIQMLQRAGASS 236
Query: 228 QVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTR 287
+ +S ++ HST R
Sbjct: 237 ESRPQSADQ-------------------------HSTHRM------------------RT 253
Query: 288 ERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIY 347
E KAA TL +I+G F +CW PFFV +V D + + FL WLGY+NS +NP +Y
Sbjct: 254 ETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFL-WLGYINSGLNPFLY 312
Query: 348 TIFNEDFKKAFQKLVRC 364
N+ F++AF ++ C
Sbjct: 313 AFLNKSFRRAFLIILCC 329
>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
Length = 360
Score = 164 bits (416), Expect = 9e-41
Identities = 119/377 (31%), Positives = 175/377 (46%), Gaps = 64/377 (16%)
Query: 4 LNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHH-PANYLI 62
++ D N++SEE + +L++ LS + LM N LV+ A+ R+L NY I
Sbjct: 1 MDKLDANVSSEEGFGSVEKVVLLTF-LSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFI 59
Query: 63 CSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRY 122
SLA D LV+VLVMPF + +V++ WI G+V C + S+D+ T SI HL I+LDRY
Sbjct: 60 VSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRY 119
Query: 123 RAI-TDAVEYARKRTPKHAGIMITIVWIISVFISMPPLF--WRHQG------------TS 167
AI + Y K TP +M+ W+I FIS P+ W + G S
Sbjct: 120 YAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNS 179
Query: 168 RDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNG 227
C+ + + S AFYIP L+++ YY+IY AK H Q + + +
Sbjct: 180 NSTYCVFMVNKPYAITCSVV-AFYIPFLLMVLAYYRIYVTAKE--HAHQIQMLQRAGASS 236
Query: 228 QVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTR 287
+ +S ++ HST R
Sbjct: 237 ESRPQSADQ-------------------------HSTHRM------------------RT 253
Query: 288 ERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIY 347
E KAA TL +I+G F +CW PFFV +V D + + FL WLGY+NS +NP +Y
Sbjct: 254 ETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFL-WLGYINSGLNPFLY 312
Query: 348 TIFNEDFKKAFQKLVRC 364
N+ F++AF ++ C
Sbjct: 313 AFLNKSFRRAFLIILCC 329
>gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]
Length = 387
Score = 164 bits (416), Expect = 9e-41
Identities = 119/377 (31%), Positives = 175/377 (46%), Gaps = 64/377 (16%)
Query: 4 LNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHH-PANYLI 62
++ D N++SEE + +L++ LS + LM N LV+ A+ R+L NY I
Sbjct: 1 MDKLDANVSSEEGFGSVEKVVLLTF-LSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFI 59
Query: 63 CSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRY 122
SLA D LV+VLVMPF + +V++ WI G+V C + S+D+ T SI HL I+LDRY
Sbjct: 60 VSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRY 119
Query: 123 RAI-TDAVEYARKRTPKHAGIMITIVWIISVFISMPPLF--WRHQG------------TS 167
AI + Y K TP +M+ W+I FIS P+ W + G S
Sbjct: 120 YAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNS 179
Query: 168 RDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNG 227
C+ + + S AFYIP L+++ YY+IY AK H Q + + +
Sbjct: 180 NSTYCVFMVNKPYAITCSVV-AFYIPFLLMVLAYYRIYVTAKE--HAHQIQMLQRAGASS 236
Query: 228 QVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTR 287
+ +S ++ HST R
Sbjct: 237 ESRPQSADQ-------------------------HSTHRM------------------RT 253
Query: 288 ERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIY 347
E KAA TL +I+G F +CW PFFV +V D + + FL WLGY+NS +NP +Y
Sbjct: 254 ETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFL-WLGYINSGLNPFLY 312
Query: 348 TIFNEDFKKAFQKLVRC 364
N+ F++AF ++ C
Sbjct: 313 AFLNKSFRRAFLIILCC 329
>gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]
Length = 378
Score = 164 bits (416), Expect = 9e-41
Identities = 119/377 (31%), Positives = 175/377 (46%), Gaps = 64/377 (16%)
Query: 4 LNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHH-PANYLI 62
++ D N++SEE + +L++ LS + LM N LV+ A+ R+L NY I
Sbjct: 1 MDKLDANVSSEEGFGSVEKVVLLTF-LSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFI 59
Query: 63 CSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRY 122
SLA D LV+VLVMPF + +V++ WI G+V C + S+D+ T SI HL I+LDRY
Sbjct: 60 VSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRY 119
Query: 123 RAI-TDAVEYARKRTPKHAGIMITIVWIISVFISMPPLF--WRHQG------------TS 167
AI + Y K TP +M+ W+I FIS P+ W + G S
Sbjct: 120 YAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNS 179
Query: 168 RDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNG 227
C+ + + S AFYIP L+++ YY+IY AK H Q + + +
Sbjct: 180 NSTYCVFMVNKPYAITCSVV-AFYIPFLLMVLAYYRIYVTAKE--HAHQIQMLQRAGASS 236
Query: 228 QVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTR 287
+ +S ++ HST R
Sbjct: 237 ESRPQSADQ-------------------------HSTHRM------------------RT 253
Query: 288 ERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIY 347
E KAA TL +I+G F +CW PFFV +V D + + FL WLGY+NS +NP +Y
Sbjct: 254 ETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFL-WLGYINSGLNPFLY 312
Query: 348 TIFNEDFKKAFQKLVRC 364
N+ F++AF ++ C
Sbjct: 313 AFLNKSFRRAFLIILCC 329
>gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]
Length = 388
Score = 164 bits (416), Expect = 9e-41
Identities = 119/377 (31%), Positives = 175/377 (46%), Gaps = 64/377 (16%)
Query: 4 LNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHH-PANYLI 62
++ D N++SEE + +L++ LS + LM N LV+ A+ R+L NY I
Sbjct: 1 MDKLDANVSSEEGFGSVEKVVLLTF-LSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFI 59
Query: 63 CSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRY 122
SLA D LV+VLVMPF + +V++ WI G+V C + S+D+ T SI HL I+LDRY
Sbjct: 60 VSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRY 119
Query: 123 RAI-TDAVEYARKRTPKHAGIMITIVWIISVFISMPPLF--WRHQG------------TS 167
AI + Y K TP +M+ W+I FIS P+ W + G S
Sbjct: 120 YAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNS 179
Query: 168 RDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNG 227
C+ + + S AFYIP L+++ YY+IY AK H Q + + +
Sbjct: 180 NSTYCVFMVNKPYAITCSVV-AFYIPFLLMVLAYYRIYVTAKE--HAHQIQMLQRAGASS 236
Query: 228 QVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTR 287
+ +S ++ HST R
Sbjct: 237 ESRPQSADQ-------------------------HSTHRM------------------RT 253
Query: 288 ERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIY 347
E KAA TL +I+G F +CW PFFV +V D + + FL WLGY+NS +NP +Y
Sbjct: 254 ETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFL-WLGYINSGLNPFLY 312
Query: 348 TIFNEDFKKAFQKLVRC 364
N+ F++AF ++ C
Sbjct: 313 AFLNKSFRRAFLIILCC 329
>gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens]
Length = 402
Score = 162 bits (411), Expect = 3e-40
Identities = 122/390 (31%), Positives = 179/390 (45%), Gaps = 76/390 (19%)
Query: 4 LNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHH-PANYLI 62
++ D N++SEE + +L++ LS + LM N LV+ A+ R+L NY I
Sbjct: 1 MDKLDANVSSEEGFGSVEKVVLLTF-LSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFI 59
Query: 63 CSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRY 122
SLA D LV+VLVMPF + +V++ WI G+V C + S+D+ T SI HL I+LDRY
Sbjct: 60 VSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRY 119
Query: 123 RAI-TDAVEYARKRTPKHAGIMITIVWIISVFISMPPLF--WR-----------HQGTSR 168
AI + Y K TP +M+ W+I FIS P+ W +QG +
Sbjct: 120 YAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLERSLNQGLGQ 179
Query: 169 DDECIIKH--DHIVSTIYSTF------------GAFYIPLALILILYYKIYRAAKTLYHK 214
D I K + ++ Y F AFYIP L+++ YY+IY AK H
Sbjct: 180 DFHAIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKE--HA 237
Query: 215 RQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKH 274
Q + + + + +S ++ HST R
Sbjct: 238 HQIQMLQRAGASSESRPQSADQ-------------------------HSTHRM------- 265
Query: 275 EKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAW 334
E KAA TL +I+G F +CW PFFV +V D + + FL W
Sbjct: 266 -----------RTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFL-W 313
Query: 335 LGYLNSLINPLIYTIFNEDFKKAFQKLVRC 364
LGY+NS +NP +Y N+ F++AF ++ C
Sbjct: 314 LGYINSGLNPFLYAFLNKSFRRAFLIILCC 343
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.326 0.137 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,301,923
Number of Sequences: 37866
Number of extensions: 472404
Number of successful extensions: 3351
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 512
Number of HSP's successfully gapped in prelim test: 163
Number of HSP's that attempted gapping in prelim test: 1821
Number of HSP's gapped (non-prelim): 1233
length of query: 366
length of database: 18,247,518
effective HSP length: 104
effective length of query: 262
effective length of database: 14,309,454
effective search space: 3749076948
effective search space used: 3749076948
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.