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Search of human proteins with 238859653
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|238859653 pleckstrin homology domain containing family A
member 4 isoform 2 [Homo sapiens]
(583 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|238859653 pleckstrin homology domain containing family A memb... 1201 0.0
gi|238859651 pleckstrin homology domain containing family A memb... 1132 0.0
gi|239047795 pleckstrin homology domain containing, family A mem... 173 4e-43
gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ... 147 3e-35
gi|219689123 pleckstrin homology domain containing, family A mem... 143 4e-34
gi|19923493 pleckstrin homology domain containing, family A memb... 143 4e-34
gi|188497618 connector enhancer of kinase suppressor of Ras 1 [H... 67 6e-11
gi|24432056 hypothetical protein LOC144717 [Homo sapiens] 65 1e-10
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 64 5e-10
gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1 [... 63 9e-10
gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1 [... 63 9e-10
gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [H... 63 9e-10
gi|150170670 piccolo isoform 2 [Homo sapiens] 61 3e-09
gi|150378539 piccolo isoform 1 [Homo sapiens] 61 3e-09
gi|163965366 nascent polypeptide-associated complex alpha subuni... 60 4e-09
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens] 59 1e-08
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 57 4e-08
gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1 pre... 57 6e-08
gi|14602439 Williams Beuren syndrome chromosome region 14 isofor... 56 8e-08
gi|14602435 Williams Beuren syndrome chromosome region 14 isofor... 56 1e-07
gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Ho... 55 2e-07
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens] 54 4e-07
gi|237757312 synaptojanin 1 isoform c [Homo sapiens] 54 5e-07
gi|112734870 hypothetical protein LOC57648 [Homo sapiens] 54 5e-07
gi|55770898 Rho GTPase activating protein 25 isoform a [Homo sap... 54 5e-07
gi|7661882 Rho GTPase activating protein 25 isoform b [Homo sapi... 54 5e-07
gi|41349484 proline-rich protein BstNI subfamily 1 isoform 2 pre... 53 7e-07
gi|237757326 synaptojanin 1 isoform d [Homo sapiens] 53 9e-07
gi|237757310 synaptojanin 1 isoform a [Homo sapiens] 52 2e-06
gi|237757308 synaptojanin 1 isoform b [Homo sapiens] 52 2e-06
>gi|238859653 pleckstrin homology domain containing family A member
4 isoform 2 [Homo sapiens]
Length = 583
Score = 1201 bits (3106), Expect = 0.0
Identities = 583/583 (100%), Positives = 583/583 (100%)
Query: 1 MEGSRPRSSLSLASSASTISSLSSLSPKKPTRAVNKIHAFGKRGNALRRDPNLPVHIRGW 60
MEGSRPRSSLSLASSASTISSLSSLSPKKPTRAVNKIHAFGKRGNALRRDPNLPVHIRGW
Sbjct: 1 MEGSRPRSSLSLASSASTISSLSSLSPKKPTRAVNKIHAFGKRGNALRRDPNLPVHIRGW 60
Query: 61 LHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFT 120
LHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFT
Sbjct: 61 LHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFT 120
Query: 121 FTAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSPARPQPGEGPGGPGGP 180
FTAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSPARPQPGEGPGGPGGP
Sbjct: 121 FTAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSPARPQPGEGPGGPGGP 180
Query: 181 PEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPP 240
PEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPP
Sbjct: 181 PEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPP 240
Query: 241 SPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRG 300
SPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRG
Sbjct: 241 SPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRG 300
Query: 301 PPSEAGGGKPPRSPQHWSQEPRTQPGPPLESTFHQSLETDTLLTKLCGQDRLLRRLQEEI 360
PPSEAGGGKPPRSPQHWSQEPRTQPGPPLESTFHQSLETDTLLTKLCGQDRLLRRLQEEI
Sbjct: 301 PPSEAGGGKPPRSPQHWSQEPRTQPGPPLESTFHQSLETDTLLTKLCGQDRLLRRLQEEI 360
Query: 361 DQKQEEKEQLEAALELTRQQLGQATREAGAPGRAWGRQRLLQDRLVSVRATLCHLTQERE 420
DQKQEEKEQLEAALELTRQQLGQATREAGAPGRAWGRQRLLQDRLVSVRATLCHLTQERE
Sbjct: 361 DQKQEEKEQLEAALELTRQQLGQATREAGAPGRAWGRQRLLQDRLVSVRATLCHLTQERE 420
Query: 421 RVWDTYSGLEQELGTLRETLEYLLHLGSPQDRVSAQQQLWMVEDTLAGLGGPQKPPPHTE 480
RVWDTYSGLEQELGTLRETLEYLLHLGSPQDRVSAQQQLWMVEDTLAGLGGPQKPPPHTE
Sbjct: 421 RVWDTYSGLEQELGTLRETLEYLLHLGSPQDRVSAQQQLWMVEDTLAGLGGPQKPPPHTE 480
Query: 481 PDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLGLGSPRVSRA 540
PDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLGLGSPRVSRA
Sbjct: 481 PDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLGLGSPRVSRA 540
Query: 541 SSPEGRHLPSPQLGTKSKEHHPLLADFRRSPGAGSQPLPSPGY 583
SSPEGRHLPSPQLGTKSKEHHPLLADFRRSPGAGSQPLPSPGY
Sbjct: 541 SSPEGRHLPSPQLGTKSKEHHPLLADFRRSPGAGSQPLPSPGY 583
>gi|238859651 pleckstrin homology domain containing family A member
4 isoform 1 [Homo sapiens]
Length = 779
Score = 1132 bits (2929), Expect = 0.0
Identities = 564/612 (92%), Positives = 567/612 (92%), Gaps = 32/612 (5%)
Query: 1 MEGSRPRSSLSLASSASTISSLSSLSPKKPTRAVNKIHAFGKRGNALRRDPNLPVHIRGW 60
MEGSRPRSSLSLASSASTISSLSSLSPKKPTRAVNKIHAFGKRGNALRRDPNLPVHIRGW
Sbjct: 1 MEGSRPRSSLSLASSASTISSLSSLSPKKPTRAVNKIHAFGKRGNALRRDPNLPVHIRGW 60
Query: 61 LHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFT 120
LHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFT
Sbjct: 61 LHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFT 120
Query: 121 FTAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSPARPQPGEGPGGPGGP 180
FTAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSPARPQPGEGPGGPGGP
Sbjct: 121 FTAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSPARPQPGEGPGGPGGP 180
Query: 181 PEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPP 240
PEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPP
Sbjct: 181 PEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPP 240
Query: 241 SPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRG 300
SPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRG
Sbjct: 241 SPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRG 300
Query: 301 PPSEAGGGKPPRSPQHWSQEPRTQ-------------------------PGPPLESTFHQ 335
PPSEAGGGKPPRSPQHWSQEPRTQ PGPPLESTFHQ
Sbjct: 301 PPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRPPGTRASMVLLPGPPLESTFHQ 360
Query: 336 SLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRAW 395
SLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRAW
Sbjct: 361 SLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRAW 420
Query: 396 GRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRETLEYLLHLGSPQDRVSA 455
GRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRETLEYLLHLGSPQDRVSA
Sbjct: 421 GRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRETLEYLLHLGSPQDRVSA 480
Query: 456 QQQLWMVEDTLAGLGGPQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDW 515
QQQLWMVEDTLAGLGGPQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDW
Sbjct: 481 QQQLWMVEDTLAGLGGPQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDW 540
Query: 516 GRPPGGDKDLASPHLGLGSPRVSRASSPEGRHLPSPQLGTKSKEHHP------LLADFRR 569
GRPPGGDKDLASPHLGLGSPRVSRASSPEGRHLPSPQLGTK+ P L RR
Sbjct: 541 GRPPGGDKDLASPHLGLGSPRVSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRR 600
Query: 570 SPGAGSQPLPSP 581
+ G +P P P
Sbjct: 601 NQECG-RPFPRP 611
>gi|239047795 pleckstrin homology domain containing, family A member
7 [Homo sapiens]
Length = 1121
Score = 173 bits (438), Expect = 4e-43
Identities = 126/356 (35%), Positives = 170/356 (47%), Gaps = 44/356 (12%)
Query: 5 RPRSSLSLASSASTISSLSSLSPKKPTRAVNKIHAFGKRGNALRRDPNLPVHIRGWLHKQ 64
RP S +S S+A T S+L + K ++ +K+H+FGKR A+RR+PN+PV +RGWLHKQ
Sbjct: 115 RPSSMVSETSTAGTASTLEAKPGPKIIKSSSKVHSFGKRDQAIRRNPNVPVVVRGWLHKQ 174
Query: 65 DSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFTFTAE 124
DSSG+RLWKRRWFVL+ +CLFYYKDSREE+VLGS+ LPSY I P P R+++F A
Sbjct: 175 DSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAV 234
Query: 125 H-------------------PGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSP 165
H GMRTY +ADT ED+ W+RA+ +A++ +
Sbjct: 235 HTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQV----LSRSSLK 290
Query: 166 ARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMR 225
+ E P S E GR+ P TR RG ++ + G Q R
Sbjct: 291 RDMEKVERQAVPQANHTESCHECGRV--GPGHTRDCPHRGHDDIV--NFERQEQEGEQYR 346
Query: 226 RARSP-DLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDW 284
R P + S+ SP S + P P G A P R + + P +
Sbjct: 347 SQRDPLEGKRDRSKARSPYSPAEEDALFMDLPTGPRGQQAQPQR-----AEKNGMLPASY 401
Query: 285 GPQRQT----LSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQPGP----PLEST 332
GP Q R PR P + +HW+ R Q G PL+ T
Sbjct: 402 GPGEQNGTGGYQRAFPPRTNPEKHSQRKSNLAQVEHWA---RAQKGDSRSLPLDQT 454
Score = 108 bits (269), Expect = 2e-23
Identities = 110/411 (26%), Positives = 163/411 (39%), Gaps = 69/411 (16%)
Query: 162 PRSPARPQPGEGPGGPGGPPEVS-----------RGEEGRISESPEVTRLSRGRGRPRLL 210
P+S P G P P + EE R V +L + R +
Sbjct: 474 PKSTRHPSGGSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFR 533
Query: 211 TPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRS---APARRPPAPSGDTAPPA 267
SPT + G SP+ FT R S L +PR S +P+ PP PP
Sbjct: 534 HGSPTAPICLG-------SPE-FTDQGRSRSMLEVPRSISVPPSPSDIPPPGPPRVFPPR 585
Query: 268 RPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQPGP 327
RPHTP R+ V+PP +L P RG + RS T P
Sbjct: 586 RPHTPAERVTVKPPDQRRSVDISLGDSPRRARGHAVKNSSHVDRRSMPSMGYMTHTVSAP 645
Query: 328 PL-----ESTFHQ-----------------------------SLETDTLLTKLCGQDRLL 353
L + T+ Q +TD L+ C QDR+L
Sbjct: 646 SLHGKSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPVKIAESDTDVKLSIFCEQDRVL 705
Query: 354 RRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRAWGRQRLLQDRLVSVRATLC 413
+ L+++I +E K+QLE+ LE+ +Q+ Q + + +Q+LLQ+ LV +RA L
Sbjct: 706 QDLEDKIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQKLLQEDLVHIRAELS 765
Query: 414 HLTQERERVWDTYSGLEQELGTLRETL-EYLLHLGSPQDRVSAQQQLWMVEDTLAGLGGP 472
+ E E W+ Y LE ++ L++TL E Q++ Q+ LW +ED AGL
Sbjct: 766 RESTEMENAWNEYLKLENDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVTAGLSAN 825
Query: 473 QK-----------PPPHTEPDSPSPVLQGEESSERESLPESLELSSP-RSP 511
++ P T P P P + +SE + P+ +SP R+P
Sbjct: 826 KENFRILVESVKNPERKTVPLFPHPPVPSLSTSESKPPPQPSPPTSPVRTP 876
Score = 37.7 bits (86), Expect = 0.029
Identities = 35/104 (33%), Positives = 44/104 (42%), Gaps = 19/104 (18%)
Query: 230 PDLFTPLSRPPSPLSLPRPRSAPARRPPA----PSGDTAPPARPHTPLSRIDVRPPLDWG 285
P L T S+PP P P ++P R P P T P RPH P R V PL
Sbjct: 853 PSLSTSESKPPPQ---PSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLR-KVTSPL--- 905
Query: 286 PQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQPGPPL 329
Q T ++P PP +PP P+ +S E + PPL
Sbjct: 906 -QSPTKAKPKVEDEAPP------RPP-LPELYSPEDQPPAVPPL 941
>gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo
sapiens]
Length = 1048
Score = 147 bits (370), Expect = 3e-35
Identities = 113/380 (29%), Positives = 163/380 (42%), Gaps = 64/380 (16%)
Query: 3 GSRPRSSLSLASSASTISSLSSLSPK-KPTRAVNKIHAFGKRGNALRRDPNLPVHIRGWL 61
G RP ++ S + + +S + P + TR K AFGKR ++++R+PN PV GWL
Sbjct: 7 GKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAVAFGKRSHSMKRNPNAPVTKAGWL 66
Query: 62 HKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFTF 121
KQ SSG++ W +RWFVL CLFYYKD +EES+LGS+ L S+ + P R+ TF
Sbjct: 67 FKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNISRKHTF 126
Query: 122 TAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSPARPQPGEGPGGPGGPP 181
AEH G+RTY +A++ E+ W++A+G A+R + + A E P PP
Sbjct: 127 KAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPDSENVPP 186
Query: 182 EVSRGEEGRIS-ESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPP 240
+ S PE +RG G G +A
Sbjct: 187 SKHHQQPPHNSLPKPEPEAKTRGEG--------------DGRGCEKAE------------ 220
Query: 241 SPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRG 300
RRP P PP + + L GP + S P +P
Sbjct: 221 -------------RRPERPEVKKEPPVKAN----------GLPAGP--EPASEPGSPYPE 255
Query: 301 PPSEAGGGKPPRSPQHWSQEPRTQPGPPLESTFHQSLETDTLLTKLCGQDRLL--RRLQE 358
P GGG+ P P W ++PG ST S + +T G R R +
Sbjct: 256 GPRVPGGGEQPAQPNGWQYHSPSRPG----STAFPSQDGET-----GGHRRSFPPRTNPD 306
Query: 359 EIDQKQEEKEQLEAALELTR 378
+I Q++ QL+ + L R
Sbjct: 307 KIAQRKSSMNQLQQWVNLRR 326
Score = 72.4 bits (176), Expect = 1e-12
Identities = 73/295 (24%), Positives = 119/295 (40%), Gaps = 33/295 (11%)
Query: 287 QRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQE--PRTQP------------------G 326
Q ++ S P +P +G S A P RSP + PR++
Sbjct: 450 QPRSHSVPRSPSQGSYSRARIYSPVRSPSARFERLPPRSEDIYADPAAYVMRRSISSPKV 509
Query: 327 PPLESTFHQSL--------ETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAALELTR 378
PP F SL +TD LL KLC Q++++R + Q + EKE LE+AL T
Sbjct: 510 PPYPEVFRDSLHTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESLESALMGTH 569
Query: 379 QQLGQATREAGAPGRAWGRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRE 438
Q+L + P + ++ LQ++L+++R L T Y LE E+ L +
Sbjct: 570 QELEMFGSQPAYPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIEYEHLESEVSALHD 629
Query: 439 TLEYLLHLGSPQDRVS--AQQQLWMVEDTLAGLGGPQKPPPHTEPDSPSPVLQGEESSER 496
L L+L + + ++ Q+++W ++D + GL P T+ L +
Sbjct: 630 DLWEQLNLDTQNEVLNRQIQKEIWRIQDVMEGL-RKNNPSRGTDTAKHRGGLGPSATYSS 688
Query: 497 ESLPESLELSSPRSPETDWGRPPGGDKDLASPHLGLGSPRVSRASSPEGRHLPSP 551
S L +S SP + + G P G P+ + S + H P
Sbjct: 689 NSPASPLSSASLTSPLSPFSLVSGSQGSPTKP--GSNEPKANYEQSKKDPHQTLP 741
>gi|219689123 pleckstrin homology domain containing, family A member
5 isoform 2 [Homo sapiens]
Length = 1105
Score = 143 bits (361), Expect = 4e-34
Identities = 69/147 (46%), Positives = 101/147 (68%), Gaps = 3/147 (2%)
Query: 5 RPRSSLSLASSASTIS--SLSSLSPK-KPTRAVNKIHAFGKRGNALRRDPNLPVHIRGWL 61
RP S ++ AS+ + S ++ +SP + +RA K+H FGKR N+++R+PN PV RGWL
Sbjct: 9 RPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWL 68
Query: 62 HKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFTF 121
+KQDS+G++LWK+RWFVLS CLFYY+D +EE +LGS+LLPS+ I R++ F
Sbjct: 69 YKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAF 128
Query: 122 TAEHPGMRTYVLAADTLEDLRGWLRAL 148
A HP MRTY DT +++ W++A+
Sbjct: 129 KAAHPNMRTYYFCTDTGKEMELWMKAM 155
Score = 68.6 bits (166), Expect = 2e-11
Identities = 44/142 (30%), Positives = 70/142 (49%), Gaps = 7/142 (4%)
Query: 335 QSLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRA 394
+ ++ D L++LC QD+++ L+E++ Q +EK LE AL Q++ A
Sbjct: 562 EEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQEIEMHADNPAAIQTV 621
Query: 395 WGRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRETL-EYLLHLGSPQ--- 450
++ LQ+ L+S L T E ER W Y LE ++ R + E L HLG Q
Sbjct: 622 VLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQEQLDHLGEVQTES 681
Query: 451 ---DRVSAQQQLWMVEDTLAGL 469
R Q++LW ++D + GL
Sbjct: 682 AGIQRAQIQKELWRIQDVMEGL 703
>gi|19923493 pleckstrin homology domain containing, family A member
5 isoform 1 [Homo sapiens]
Length = 1116
Score = 143 bits (361), Expect = 4e-34
Identities = 69/147 (46%), Positives = 101/147 (68%), Gaps = 3/147 (2%)
Query: 5 RPRSSLSLASSASTIS--SLSSLSPK-KPTRAVNKIHAFGKRGNALRRDPNLPVHIRGWL 61
RP S ++ AS+ + S ++ +SP + +RA K+H FGKR N+++R+PN PV RGWL
Sbjct: 117 RPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWL 176
Query: 62 HKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFTF 121
+KQDS+G++LWK+RWFVLS CLFYY+D +EE +LGS+LLPS+ I R++ F
Sbjct: 177 YKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAF 236
Query: 122 TAEHPGMRTYVLAADTLEDLRGWLRAL 148
A HP MRTY DT +++ W++A+
Sbjct: 237 KAAHPNMRTYYFCTDTGKEMELWMKAM 263
Score = 68.9 bits (167), Expect = 1e-11
Identities = 46/153 (30%), Positives = 74/153 (48%), Gaps = 7/153 (4%)
Query: 335 QSLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRA 394
+ ++ D L++LC QD+++ L+E++ Q +EK LE AL Q++ A
Sbjct: 631 EEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQEIEMHADNPAAIQTV 690
Query: 395 WGRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRETL-EYLLHLGSPQ--- 450
++ LQ+ L+S L T E ER W Y LE ++ R + E L HLG Q
Sbjct: 691 VLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQEQLDHLGEVQTES 750
Query: 451 ---DRVSAQQQLWMVEDTLAGLGGPQKPPPHTE 480
R Q++LW ++D + GL ++ TE
Sbjct: 751 AGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTE 783
>gi|188497618 connector enhancer of kinase suppressor of Ras 1 [Homo
sapiens]
Length = 713
Score = 66.6 bits (161), Expect = 6e-11
Identities = 61/212 (28%), Positives = 91/212 (42%), Gaps = 41/212 (19%)
Query: 59 GWLHKQDSSGLRL---WKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPR 115
GWL + + G + W+RRWFVL GH L++Y+ ++E G + + +Y++ G +
Sbjct: 401 GWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLE---SGHDQ 457
Query: 116 GRRFTFTAEHPGMRTYVLAADTLEDLRGWLRAL----------GRA---------SRAEG 156
+++ F H + ++ AADTL DL W+R L GRA S E
Sbjct: 458 KKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLITCISKYQSPGRAPPPREEDCYSETEA 517
Query: 157 DD-------YGQPRSPARP-QPGEGPGGPGGPP--EVSRGEEGRISESPE-----VTRLS 201
+D + SPA+ P G P P R G +++S E + R
Sbjct: 518 EDPDDEAGSHSASPSPAQAGSPLHGDTSPAATPTQRSPRTSFGSLTDSSEEALEGMVRGL 577
Query: 202 RGRGRPRLLTPSP-TTDLHSGLQMRRARSPDL 232
R G L P P T + MRR R P L
Sbjct: 578 RQGGVSLLGQPQPLTQEQWRSSFMRRNRDPQL 609
>gi|24432056 hypothetical protein LOC144717 [Homo sapiens]
Length = 249
Score = 65.5 bits (158), Expect = 1e-10
Identities = 66/231 (28%), Positives = 91/231 (39%), Gaps = 39/231 (16%)
Query: 54 PVHIRGWLHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGA 113
PV G+L+K+ + RRWFVL G+ LFY++D+ +G ++L +
Sbjct: 17 PVDNAGFLYKKGGRHAA-YHRRWFVLRGNMLFYFEDAASREPVGVIILEGCTVEL----V 71
Query: 114 PRGRRFTFTAEHPG--MRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSPARPQPG 171
F F G RTYVLAA++ + + GW++AL RAS + R R
Sbjct: 72 EAAEEFAFAVRFAGTRARTYVLAAESQDAMEGWVKALSRAS------FDYLRLVVRELEQ 125
Query: 172 EGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPD 231
+ RG G P+ L P L P P+ + A +P
Sbjct: 126 Q--------LAAVRGGGGMALPQPQPQSLPLPPSLPSALAPVPS--------LPSAPAPV 169
Query: 232 LFTPLSRPPSPLSLPRPR-----SAPARRPPAPSGDTAPPAR----PHTPL 273
PL R PS L P+ S A P P PP R PH PL
Sbjct: 170 PALPLPRRPSALP-PKENGCAVWSTEATFRPGPEPPPPPPRRRASAPHGPL 219
Score = 36.2 bits (82), Expect = 0.086
Identities = 28/88 (31%), Positives = 31/88 (35%), Gaps = 27/88 (30%)
Query: 240 PSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRR 299
P P SLP P S P+ P PS +AP P PL P P
Sbjct: 141 PQPQSLPLPPSLPSALAPVPSLPSAPAPVPALPL--------------------PRRPSA 180
Query: 300 GPPSEAGGGKPPRSPQHWSQEPRTQPGP 327
PP E G WS E +PGP
Sbjct: 181 LPPKENGCAV-------WSTEATFRPGP 201
>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
sapiens]
Length = 748
Score = 63.5 bits (153), Expect = 5e-10
Identities = 36/103 (34%), Positives = 51/103 (49%), Gaps = 15/103 (14%)
Query: 59 GWLHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNI-----RPDGPG- 112
GWL KQ ++ W RWFVL G L+Y+KD E LG++ LP + + PG
Sbjct: 24 GWLRKQGGF-VKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVSEHPCNEENPGK 82
Query: 113 -----APRGRRFTFTAEHPGMRTYVLAADTLEDLRGWLRALGR 150
P G R TA H +Y+L A T D+ W++++ R
Sbjct: 83 FLFEVVPGGDRDRMTANH---ESYLLMASTQNDMEDWVKSIRR 122
>gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1
[Homo sapiens]
Length = 438
Score = 62.8 bits (151), Expect = 9e-10
Identities = 46/189 (24%), Positives = 77/189 (40%), Gaps = 13/189 (6%)
Query: 58 RGWLHKQDSSGLRL---WKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAP 114
+GWL+K+ G L WK+ W +L G L++Y + E G V LP + + +
Sbjct: 46 QGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVE---RASE 102
Query: 115 RGRRFTFTAEHPGMRTYVLAADTLEDLRGWLRALGRA------SRAEGDDYGQPRSPARP 168
++ F HP ++T+ AA+ ++++ WL LG A + + + Y +
Sbjct: 103 CKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPE 162
Query: 169 QPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRAR 228
E P P S + S SP ++ S +P++ S L R
Sbjct: 163 IAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTPSS-FPSSLSKERQS 221
Query: 229 SPDLFTPLS 237
PD LS
Sbjct: 222 LPDTVNSLS 230
>gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1
[Homo sapiens]
Length = 438
Score = 62.8 bits (151), Expect = 9e-10
Identities = 46/189 (24%), Positives = 77/189 (40%), Gaps = 13/189 (6%)
Query: 58 RGWLHKQDSSGLRL---WKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAP 114
+GWL+K+ G L WK+ W +L G L++Y + E G V LP + + +
Sbjct: 46 QGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVE---RASE 102
Query: 115 RGRRFTFTAEHPGMRTYVLAADTLEDLRGWLRALGRA------SRAEGDDYGQPRSPARP 168
++ F HP ++T+ AA+ ++++ WL LG A + + + Y +
Sbjct: 103 CKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPE 162
Query: 169 QPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRAR 228
E P P S + S SP ++ S +P++ S L R
Sbjct: 163 IAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTPSS-FPSSLSKERQS 221
Query: 229 SPDLFTPLS 237
PD LS
Sbjct: 222 LPDTVNSLS 230
>gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [Homo
sapiens]
Length = 437
Score = 62.8 bits (151), Expect = 9e-10
Identities = 46/189 (24%), Positives = 77/189 (40%), Gaps = 13/189 (6%)
Query: 58 RGWLHKQDSSGLRL---WKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAP 114
+GWL+K+ G L WK+ W +L G L++Y + E G V LP + + +
Sbjct: 45 QGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVE---RASE 101
Query: 115 RGRRFTFTAEHPGMRTYVLAADTLEDLRGWLRALGRA------SRAEGDDYGQPRSPARP 168
++ F HP ++T+ AA+ ++++ WL LG A + + + Y +
Sbjct: 102 CKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPE 161
Query: 169 QPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRAR 228
E P P S + S SP ++ S +P++ S L R
Sbjct: 162 IAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTPSS-FPSSLSKERQS 220
Query: 229 SPDLFTPLS 237
PD LS
Sbjct: 221 LPDTVNSLS 229
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 60.8 bits (146), Expect = 3e-09
Identities = 49/176 (27%), Positives = 68/176 (38%), Gaps = 28/176 (15%)
Query: 165 PARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSR--GRGRPRLLTPSPTTD--LHS 220
P +P P GP PP G E SE P L++ G G+ P P
Sbjct: 356 PGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQV 415
Query: 221 GLQMRRARSPDLFTPLSRP---------PSPLSLPRPRSAPARRPPAPSGDTAPPARPHT 271
G A+ P L +P P P P +P ++ P + +G T PP++
Sbjct: 416 GTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPG 475
Query: 272 PLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQPGP 327
P +PP PQ+ P P + PP + G KPP ++ P QPGP
Sbjct: 476 P-----AKPP----PQQ------PGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGP 516
Score = 48.1 bits (113), Expect = 2e-05
Identities = 100/464 (21%), Positives = 165/464 (35%), Gaps = 84/464 (18%)
Query: 162 PRSPARPQPGEGPG-----GPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTT 216
P++ A+P PG G GP PP G +++ P + ++ G + P
Sbjct: 388 PKALAQP-PGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGP 446
Query: 217 DLHSGLQMRRARSPDLFTPLSRPPS----PLSLPRPRSAPARRPPA-------PS---GD 262
Q ++ T ++PPS P P + PA+ PP PS G
Sbjct: 447 GKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGS 506
Query: 263 TAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPP------------SEAGGGKP 310
T PP + P +P P +Q S P+ ++ P S+ G GKP
Sbjct: 507 TKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKP 566
Query: 311 PRSPQHWSQEPRTQPGPPLESTFHQSLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQL 370
+ P S + P L T + LC LL + E+ +
Sbjct: 567 LQPPT-VSPSAKQPPSQGLPKT----------ICPLCNTTELLLHVPEKANFN------- 608
Query: 371 EAALELTRQQLGQATREAGAPGRAWGRQRLLQDRLVSVRATLCHLTQERERVWDTY---- 426
T Q + P L V+ LC Q + +
Sbjct: 609 ----TCTECQTTVCSLCGFNP----------NPHLTEVKEWLCLNCQMKRALGGDLAPVP 654
Query: 427 SGLEQELGTLRETLEYLLHLGSPQDRVSAQQQLWMVEDTLAGLGGPQKPPPHTEPDSPSP 486
S + +L T T + SPQ + ++ ++ + L+ P+KPPP + P
Sbjct: 655 SSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVK----QP 710
Query: 487 VLQGEESSERESLPESLELSSPRSPE-----TDWGRPPGGDKDLASPHL-GLGSPRVSRA 540
L G S++ + PE+ LS P P+ ++ + P D P + + VS +
Sbjct: 711 TLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSS 770
Query: 541 SSPEGRHLPSPQLGTKSKEH--HPLLADFRRSPGAGSQPLPSPG 582
S+ +PS ++ ++++E PL D + SQ P G
Sbjct: 771 SATTKPDIPSSKVQSQAEEKTTPPLKTDSAKP----SQSFPPTG 810
Score = 45.8 bits (107), Expect = 1e-04
Identities = 52/205 (25%), Positives = 80/205 (39%), Gaps = 39/205 (19%)
Query: 160 GQPRSPARPQPGE------GPGGP-GGPPEVSRGEEGRISESPEVTR-------LSRGRG 205
G P+S + QP + G G P GP + + + ++ + +R + RG
Sbjct: 234 GTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGES 293
Query: 206 -RPRLLTPS------PTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRP---RSAPARR 255
+P L +PS PT Q +S P P P L +P + +
Sbjct: 294 VKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQP--GPAKPPAQPSGLTKPLAQQPGTVKP 351
Query: 256 PPAPSGDTAPPARP----HTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPP 311
P P G T PPA+P P + P P + L++PP + P + G KPP
Sbjct: 352 PVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPP 411
Query: 312 R----SPQHWSQEPRTQ-----PGP 327
+P+ +Q+P Q PGP
Sbjct: 412 TQQVGTPKPLAQQPGLQSPAKAPGP 436
Score = 39.3 bits (90), Expect = 0.010
Identities = 42/185 (22%), Positives = 65/185 (35%), Gaps = 41/185 (22%)
Query: 162 PRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLT---------P 212
P+ A+P P P PG P G+ +P+ + + + R L
Sbjct: 864 PKPDAKPMPKGSPTPPGPRPTA-----GQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKS 918
Query: 213 SPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRS-----APARRPPAPSGDTAPPA 267
PTT + +F+ S S P P S AP ++ PAPS
Sbjct: 919 QPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPS------- 971
Query: 268 RPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQPGP 327
+PP GP + T PP P + P + K ++P EP+ + P
Sbjct: 972 -----------QPPTSQGPPKSTGQAPPAPAKSIPVK----KETKAPAAEKLEPKAEQAP 1016
Query: 328 PLEST 332
++ T
Sbjct: 1017 TVKRT 1021
Score = 36.6 bits (83), Expect = 0.065
Identities = 53/264 (20%), Positives = 91/264 (34%), Gaps = 53/264 (20%)
Query: 138 LEDLRGWLRALGRASRAEGDDYGQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEV 197
L +++ WL + RA G D P+ PQP ++ +P
Sbjct: 629 LTEVKEWLCLNCQMKRALGGDLAPV--PSSPQP-------------------KLKTAPVT 667
Query: 198 TRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPL--------------SRPPSPL 243
T + + P+ SP D + +A P PL +PP
Sbjct: 668 TTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEAD 727
Query: 244 SLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTP------ 297
SL +P AP + P PS P P V+P D ++P P
Sbjct: 728 SLSKP--APPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQS 785
Query: 298 ----RRGPPSEAGGGKPPRSPQHWSQEPRTQPGPPLESTFHQSLETDTLLTKLCGQDRLL 353
+ PP + KP + S P + P +S +D+ + G
Sbjct: 786 QAEEKTTPPLKTDSAKPSQ-----SFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSES 840
Query: 354 RRLQEEIDQKQEEKEQLEAALELT 377
+ Q+++D Q+++E +A +++
Sbjct: 841 KG-QKQVDPVQKKEEPKKAQTKMS 863
Score = 35.4 bits (80), Expect = 0.15
Identities = 24/81 (29%), Positives = 36/81 (44%), Gaps = 8/81 (9%)
Query: 474 KPPPHTEPDSPSPVLQ--GEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLG 531
KPP +P P P Q G + +++ P+S+ S + PE +PPG K + P
Sbjct: 208 KPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSI---SSQQPEKIKSQPPGTGKPIQGP--- 261
Query: 532 LGSPRVSRASSPEGRHLPSPQ 552
+P+ A P R PQ
Sbjct: 262 TQTPQTDHAKLPLQRDASRPQ 282
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 60.8 bits (146), Expect = 3e-09
Identities = 49/176 (27%), Positives = 68/176 (38%), Gaps = 28/176 (15%)
Query: 165 PARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSR--GRGRPRLLTPSPTTD--LHS 220
P +P P GP PP G E SE P L++ G G+ P P
Sbjct: 356 PGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQV 415
Query: 221 GLQMRRARSPDLFTPLSRP---------PSPLSLPRPRSAPARRPPAPSGDTAPPARPHT 271
G A+ P L +P P P P +P ++ P + +G T PP++
Sbjct: 416 GTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPG 475
Query: 272 PLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQPGP 327
P +PP PQ+ P P + PP + G KPP ++ P QPGP
Sbjct: 476 P-----AKPP----PQQ------PGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGP 516
Score = 48.1 bits (113), Expect = 2e-05
Identities = 100/464 (21%), Positives = 165/464 (35%), Gaps = 84/464 (18%)
Query: 162 PRSPARPQPGEGPG-----GPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTT 216
P++ A+P PG G GP PP G +++ P + ++ G + P
Sbjct: 388 PKALAQP-PGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGP 446
Query: 217 DLHSGLQMRRARSPDLFTPLSRPPS----PLSLPRPRSAPARRPPA-------PS---GD 262
Q ++ T ++PPS P P + PA+ PP PS G
Sbjct: 447 GKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGS 506
Query: 263 TAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPP------------SEAGGGKP 310
T PP + P +P P +Q S P+ ++ P S+ G GKP
Sbjct: 507 TKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKP 566
Query: 311 PRSPQHWSQEPRTQPGPPLESTFHQSLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQL 370
+ P S + P L T + LC LL + E+ +
Sbjct: 567 LQPPT-VSPSAKQPPSQGLPKT----------ICPLCNTTELLLHVPEKANFN------- 608
Query: 371 EAALELTRQQLGQATREAGAPGRAWGRQRLLQDRLVSVRATLCHLTQERERVWDTY---- 426
T Q + P L V+ LC Q + +
Sbjct: 609 ----TCTECQTTVCSLCGFNP----------NPHLTEVKEWLCLNCQMKRALGGDLAPVP 654
Query: 427 SGLEQELGTLRETLEYLLHLGSPQDRVSAQQQLWMVEDTLAGLGGPQKPPPHTEPDSPSP 486
S + +L T T + SPQ + ++ ++ + L+ P+KPPP + P
Sbjct: 655 SSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVK----QP 710
Query: 487 VLQGEESSERESLPESLELSSPRSPE-----TDWGRPPGGDKDLASPHL-GLGSPRVSRA 540
L G S++ + PE+ LS P P+ ++ + P D P + + VS +
Sbjct: 711 TLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSS 770
Query: 541 SSPEGRHLPSPQLGTKSKEH--HPLLADFRRSPGAGSQPLPSPG 582
S+ +PS ++ ++++E PL D + SQ P G
Sbjct: 771 SATTKPDIPSSKVQSQAEEKTTPPLKTDSAKP----SQSFPPTG 810
Score = 45.8 bits (107), Expect = 1e-04
Identities = 52/205 (25%), Positives = 80/205 (39%), Gaps = 39/205 (19%)
Query: 160 GQPRSPARPQPGE------GPGGP-GGPPEVSRGEEGRISESPEVTR-------LSRGRG 205
G P+S + QP + G G P GP + + + ++ + +R + RG
Sbjct: 234 GTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGES 293
Query: 206 -RPRLLTPS------PTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRP---RSAPARR 255
+P L +PS PT Q +S P P P L +P + +
Sbjct: 294 VKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQP--GPAKPPAQPSGLTKPLAQQPGTVKP 351
Query: 256 PPAPSGDTAPPARP----HTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPP 311
P P G T PPA+P P + P P + L++PP + P + G KPP
Sbjct: 352 PVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPP 411
Query: 312 R----SPQHWSQEPRTQ-----PGP 327
+P+ +Q+P Q PGP
Sbjct: 412 TQQVGTPKPLAQQPGLQSPAKAPGP 436
Score = 39.3 bits (90), Expect = 0.010
Identities = 42/185 (22%), Positives = 65/185 (35%), Gaps = 41/185 (22%)
Query: 162 PRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLT---------P 212
P+ A+P P P PG P G+ +P+ + + + R L
Sbjct: 864 PKPDAKPMPKGSPTPPGPRPTA-----GQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKS 918
Query: 213 SPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRS-----APARRPPAPSGDTAPPA 267
PTT + +F+ S S P P S AP ++ PAPS
Sbjct: 919 QPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPS------- 971
Query: 268 RPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQPGP 327
+PP GP + T PP P + P + K ++P EP+ + P
Sbjct: 972 -----------QPPTSQGPPKSTGQAPPAPAKSIPVK----KETKAPAAEKLEPKAEQAP 1016
Query: 328 PLEST 332
++ T
Sbjct: 1017 TVKRT 1021
Score = 36.6 bits (83), Expect = 0.065
Identities = 53/264 (20%), Positives = 91/264 (34%), Gaps = 53/264 (20%)
Query: 138 LEDLRGWLRALGRASRAEGDDYGQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEV 197
L +++ WL + RA G D P+ PQP ++ +P
Sbjct: 629 LTEVKEWLCLNCQMKRALGGDLAPV--PSSPQP-------------------KLKTAPVT 667
Query: 198 TRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPL--------------SRPPSPL 243
T + + P+ SP D + +A P PL +PP
Sbjct: 668 TTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEAD 727
Query: 244 SLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTP------ 297
SL +P AP + P PS P P V+P D ++P P
Sbjct: 728 SLSKP--APPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQS 785
Query: 298 ----RRGPPSEAGGGKPPRSPQHWSQEPRTQPGPPLESTFHQSLETDTLLTKLCGQDRLL 353
+ PP + KP + S P + P +S +D+ + G
Sbjct: 786 QAEEKTTPPLKTDSAKPSQ-----SFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSES 840
Query: 354 RRLQEEIDQKQEEKEQLEAALELT 377
+ Q+++D Q+++E +A +++
Sbjct: 841 KG-QKQVDPVQKKEEPKKAQTKMS 863
Score = 35.4 bits (80), Expect = 0.15
Identities = 24/81 (29%), Positives = 36/81 (44%), Gaps = 8/81 (9%)
Query: 474 KPPPHTEPDSPSPVLQ--GEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLG 531
KPP +P P P Q G + +++ P+S+ S + PE +PPG K + P
Sbjct: 208 KPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSI---SSQQPEKIKSQPPGTGKPIQGP--- 261
Query: 532 LGSPRVSRASSPEGRHLPSPQ 552
+P+ A P R PQ
Sbjct: 262 TQTPQTDHAKLPLQRDASRPQ 282
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 60.5 bits (145), Expect = 4e-09
Identities = 51/171 (29%), Positives = 64/171 (37%), Gaps = 18/171 (10%)
Query: 165 PARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQM 224
PA P P P P P +G G + SP +G P TP +
Sbjct: 954 PATPSPKWAPTPPAATPPSPKG--GPATPSP------KGAPTPPAATPPSPKGGPATPSP 1005
Query: 225 RRARSPDLFTPLSRPPSPLSLPRPRSA---PARRPPAPSGDTA----PPARPHTPLSRID 277
+ A +P TP S SP + P P+ A PA PP+P G A P P TP + +
Sbjct: 1006 KGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATL- 1064
Query: 278 VRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQPGPP 328
P GP +L PTP P GG SP+ P P P
Sbjct: 1065 --PSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSP 1113
Score = 52.0 bits (123), Expect = 2e-06
Identities = 53/185 (28%), Positives = 67/185 (36%), Gaps = 31/185 (16%)
Query: 162 PRSP----ARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTD 217
P SP A P P P P P +G G + SP +G P TP+ T
Sbjct: 1156 PPSPKGGLATPPPKGAPTTPAATPPSPKG--GLATPSP--------KGAPT--TPAATPP 1203
Query: 218 LHSGLQMRRARSPDLFTPLSRPPSP---LSLPRPRSAP---ARRPPAPSGDTAPPARPHT 271
G + TP + PPSP L+ P P+ AP A PP+P G A P
Sbjct: 1204 SPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGA 1263
Query: 272 PLSRIDVRP--------PLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRT 323
P P P G + PP+P+ GP + G P P P+
Sbjct: 1264 PTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKG-APTPPAATPPSPKG 1322
Query: 324 QPGPP 328
PG P
Sbjct: 1323 SPGTP 1327
Score = 50.8 bits (120), Expect = 3e-06
Identities = 54/184 (29%), Positives = 66/184 (35%), Gaps = 25/184 (13%)
Query: 160 GQPRSPAR--PQPGEGP------GGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLT 211
G P PA P P GP G P P +G ++ P +G P T
Sbjct: 1078 GAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPH-------KGAPT--T 1128
Query: 212 PSPTTDLHSGLQMRRARSPDLFTPLSRPPSP---LSLPRPRSAP---ARRPPAPSGDTAP 265
P+ T G TP + PPSP L+ P P+ AP A PP+P G A
Sbjct: 1129 PAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLAT 1188
Query: 266 PARPHTPLSRIDVRPPLDWG-PQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQ 324
P+ P + P G P TP PPS GG P SP+ P
Sbjct: 1189 PSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATP-SPKGAPTTPAAT 1247
Query: 325 PGPP 328
P P
Sbjct: 1248 PPSP 1251
Score = 49.3 bits (116), Expect = 1e-05
Identities = 48/195 (24%), Positives = 64/195 (32%), Gaps = 10/195 (5%)
Query: 157 DDYGQPRSPARPQPGEGPGGPGGPPEVSRGEE--GRISESPEVTRLSRGRGRPRLLTPSP 214
D SP P P P P +G + + +P V L + P P
Sbjct: 848 DSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQ 907
Query: 215 TTDLH-SGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPL 273
L + ++AR+ + PSP P P PA PP+P G A P+ P
Sbjct: 908 APALSMTSSSPKKARATPAPKGIPASPSPKGAPTP---PAATPPSPKGGPATPSPKWAPT 964
Query: 274 SRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQP----GPPL 329
P GP + PTP P GG SP+ P P G P
Sbjct: 965 PPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPA 1024
Query: 330 ESTFHQSLETDTLLT 344
+ F + T T
Sbjct: 1025 ATPFPKGASTPPAAT 1039
Score = 49.3 bits (116), Expect = 1e-05
Identities = 52/178 (29%), Positives = 67/178 (37%), Gaps = 14/178 (7%)
Query: 160 GQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRG-RGRPRLLTPSPTTDL 218
G P +PA P G PP+ + SP+ + +G P TP+ T
Sbjct: 1124 GAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPT--TPAATPPS 1181
Query: 219 HSGLQMRRARSPDLFTPLSRPPSP---LSLPRPRSAP---ARRPPAPSGDTAPPARPHTP 272
G + TP + PPSP L+ P P+ AP A PP+P G A P+ P
Sbjct: 1182 PKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAP 1241
Query: 273 LSRIDVRPPLDWGPQRQTLSRPPTPRRG-PPSEAGGGKPPRSPQHWSQEPR--TQPGP 327
+ P GP PTP PPS GG P P + P T P P
Sbjct: 1242 TTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATP--PHKGAPNPAVVTPPSP 1297
Score = 48.5 bits (114), Expect = 2e-05
Identities = 53/176 (30%), Positives = 65/176 (36%), Gaps = 29/176 (16%)
Query: 165 PARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTP-----SPT-TDL 218
PA P P P P P +G SP T +G P TP SP T L
Sbjct: 1000 PATPSPKGAPTPPAVTPPSPKG-------SPAATPFPKGASTPPAATPPSPKGSPAATPL 1052
Query: 219 HSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDV 278
G A + L +P P +P SL + PA PP+P G A P+ P+
Sbjct: 1053 PKGAPTTPAAT--LPSPKGGPATP-SLKGAPTPPAATPPSPKGGPATPSPKGAPM----- 1104
Query: 279 RPPLDWGPQ-RQTLSRPP------TPRRGPPSEAGGGKPPRSPQHWSQEPRTQPGP 327
PP P + L+ PP TP PPS GG P + T P P
Sbjct: 1105 -PPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSP 1159
Score = 47.0 bits (110), Expect = 5e-05
Identities = 53/179 (29%), Positives = 64/179 (35%), Gaps = 33/179 (18%)
Query: 162 PRSP----ARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTD 217
P SP A P P P P P +G G + SP +G P TP+ T
Sbjct: 1179 PPSPKGGLATPSPKGAPTTPAATPPSPKG--GLATPSP--------KGAPT--TPAATPP 1226
Query: 218 LHSGLQMRRARSPDLFTPLSRPPSPL---SLPRPRSAP---ARRPPAPSGDTAPPARPHT 271
G + TP + PPSP + P P+ AP A PP+ G A P
Sbjct: 1227 SPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGA 1286
Query: 272 PLSRIDVRPPLDWGPQRQTLSRPPTPRRG-PPSEAGG-GKPPRSPQHWSQEPRTQPGPP 328
P + P GP PTP PPS G G PP P+ P PP
Sbjct: 1287 PNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPP---------PKGAPTPP 1336
Score = 42.7 bits (99), Expect = 0.001
Identities = 50/195 (25%), Positives = 61/195 (31%), Gaps = 38/195 (19%)
Query: 167 RPQPGEGPGGPGGPPEVSRGEEGRISES--PEVTRLSRGRGRPRLLTPSPTTDLHSGLQM 224
RP +G GP P + S PE + +G T SPT G
Sbjct: 807 RPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKG--- 863
Query: 225 RRARSPDLFTPLSRP-----------PSPLSLPRPRSAPA-------------------- 253
A +P TPLS PS ++LP P+ PA
Sbjct: 864 --APTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKA 921
Query: 254 RRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRS 313
R PAP G A P+ P P GP + PTP P GG S
Sbjct: 922 RATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPS 981
Query: 314 PQHWSQEPRTQPGPP 328
P+ P P P
Sbjct: 982 PKGAPTPPAATPPSP 996
Score = 42.7 bits (99), Expect = 0.001
Identities = 46/180 (25%), Positives = 62/180 (34%), Gaps = 28/180 (15%)
Query: 160 GQPRSPAR--PQPGEGP------GGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLT 211
G P +PA P P GP G P P +G ++ P +G P ++T
Sbjct: 1239 GAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPH-----KGAPNPAVVT 1293
Query: 212 PSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHT 271
P + + A +P P + PPSP P PP T P P +
Sbjct: 1294 PPSPKGGPATSPPKGAPTP----PAATPPSPKGSPGT-------PPPKGAPTPPAVTPPS 1342
Query: 272 PLSRIDV---RPPLDWGPQRQTLSRPPTPRRGPPSEAGG-GKPPRSPQHWSQEPRTQPGP 327
P + P GP + PTP PS GG P SP+ P + P
Sbjct: 1343 PKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDP 1402
Score = 40.4 bits (93), Expect = 0.005
Identities = 53/210 (25%), Positives = 67/210 (31%), Gaps = 50/210 (23%)
Query: 163 RSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTP-----SPTTD 217
R PA P P P P P + S+G P +TP +P T
Sbjct: 1391 RGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATS 1450
Query: 218 LHSGLQMRRARSPDLFTPLSRPPSPLSLPRPR-----SAPARRP--PAPSG--------D 262
G + D P PPSP P P+ S+P + P PAP G
Sbjct: 1451 APKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIP 1510
Query: 263 TAPPARPHTPLSRID----------------------VRPPLDWGPQRQTLSRPPTPRRG 300
++P P TP SR D + PP P + PTP+
Sbjct: 1511 SSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEA 1570
Query: 301 P--PSEAGGGKPPRSPQHWSQEPRTQPGPP 328
P PS PP + P T G P
Sbjct: 1571 PATPSSKEASSPP------AVTPSTYKGAP 1594
Score = 37.7 bits (86), Expect = 0.029
Identities = 45/198 (22%), Positives = 64/198 (32%), Gaps = 44/198 (22%)
Query: 160 GQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLH 219
G P PA P G PG PP + +P +G P L +P++
Sbjct: 1308 GAPTPPAATPPSP-KGSPGTPPPKG-------APTPPAVTPPSPKGTPTLPATTPSSK-- 1357
Query: 220 SGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRP---------PAPSGDTAPPA--- 267
P + P P + P + PA P P+P GD PA
Sbjct: 1358 --------GGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIP 1409
Query: 268 -----RPHTPLSRI--------DVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSP 314
P TP++R D+ PP + P+ GP + + G P P
Sbjct: 1410 LSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKG-DPTLP 1468
Query: 315 QHWSQEPRTQPGPPLEST 332
P+ P P +T
Sbjct: 1469 AVTPPSPKEPPAPKQVAT 1486
Score = 36.6 bits (83), Expect = 0.065
Identities = 44/166 (26%), Positives = 61/166 (36%), Gaps = 30/166 (18%)
Query: 163 RSPARPQPGEGPGGPG----GPPEVSRGEEGRISE-SPEVTRLSRGRGRPRLLTPSPTTD 217
++PA P P P P P EV R +P T LS+ P L P
Sbjct: 1492 KAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKT--PATLAP----- 1544
Query: 218 LHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHT----PL 273
+ A P T S +P ++P P+ APA P + + P P T P
Sbjct: 1545 -------KEALIPPAMTVPSPKKTP-AIPTPKEAPAT-PSSKEASSPPAVTPSTYKGAPS 1595
Query: 274 SRIDVRPPLDWGPQRQTLSRPP-----TPRRGPPSEAGGGKPPRSP 314
+ + PP P + PP +P +GP + A G P P
Sbjct: 1596 PKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPP 1641
Score = 34.7 bits (78), Expect = 0.25
Identities = 48/187 (25%), Positives = 59/187 (31%), Gaps = 51/187 (27%)
Query: 163 RSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRP---RLLTPSPTTDLH 219
++PA P P E P P + + SP S +G P LL P T
Sbjct: 1560 KTPAIPTPKEAPATPSS----------KEASSPPAVTPSTYKGAPSPKELLIPPAVTSPS 1609
Query: 220 SGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPS----------------GDT 263
+ A +P TP S P + P P+ P P PS G T
Sbjct: 1610 P----KEAPTPPAVTPPSPEKGPAT-PAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGAT 1664
Query: 264 APPARPHTP-------LSRIDVRP----------PLDWGPQRQTLSRPPTPRRGPPSEAG 306
P A P L + V P P GPQ + S P PS
Sbjct: 1665 VPQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKN 1724
Query: 307 GGKPPRS 313
G K P S
Sbjct: 1725 GSKGPLS 1731
Score = 31.6 bits (70), Expect = 2.1
Identities = 34/126 (26%), Positives = 44/126 (34%), Gaps = 20/126 (15%)
Query: 470 GGPQKP-------PPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGD 522
GGP P PP P SP + S P + SP+ P G
Sbjct: 998 GGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAP 1057
Query: 523 KD----LASPHLGLGSPRVSRASSPEGRHLPSPQLG--TKSKEHHPLLADFRRSPGAGSQ 576
L SP G +P + A +P PSP+ G T S + P+ P A +
Sbjct: 1058 TTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPM-------PPAATP 1110
Query: 577 PLPSPG 582
P P G
Sbjct: 1111 PSPKGG 1116
>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
Length = 698
Score = 58.9 bits (141), Expect = 1e-08
Identities = 52/155 (33%), Positives = 70/155 (45%), Gaps = 19/155 (12%)
Query: 25 LSPK--KPTRAVNKIHAFGKRGNALRRDPNL----PVHIRGWLHKQDSSGLRLWKRRWFV 78
LSPK + RA +K G++ + R P PV GWL KQ S ++ W++RWFV
Sbjct: 2 LSPKIRQARRARSKSLVMGEQSRSPGRMPCPHRLGPVLKAGWLKKQRSI-MKNWQQRWFV 60
Query: 79 LSGHCLFYYKDSREESVLGSVLLPSYNIR--PDGPGAPRGRRFTFTAEHPGMRTYV---- 132
L G LFYYKD E G + L + P GP P F + G R V
Sbjct: 61 LRGDQLFYYKDKDEIKPQGFISLQGTQVTELPPGPEDPGKHLFEISPGGAGEREKVPANP 120
Query: 133 ----LAADTLEDLRGWLRALGRASRAE--GDDYGQ 161
L A + D+ W++A+ R A G +GQ
Sbjct: 121 EALLLMASSQRDMEDWVQAIRRVIWAPLGGGIFGQ 155
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 57.4 bits (137), Expect = 4e-08
Identities = 69/214 (32%), Positives = 77/214 (35%), Gaps = 42/214 (19%)
Query: 164 SPARPQPGEGPGGPGGPPEVSR----GEEGRISESPEVTRLSRGRGRPRL--------LT 211
SP P P E P P PPE SR EE S PE LSR L L+
Sbjct: 447 SPLSPPPEESPTSP--PPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLS 504
Query: 212 PSPTTDLHSGLQM-------RRARSPDLFTPLSRPP--SPLSLPRPRSAPARRPPAPSGD 262
P P + S L+ SP L TPLS PP SPLS P S P PP
Sbjct: 505 PPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEES-PLSPPPEELPT 563
Query: 263 TAPP--ARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRR----------GPPSEAGGGKP 310
+ PP +R P + PP P+ +S PP R PP E P
Sbjct: 564 SPPPEASRLSPPPEESPMSPP----PEESPMSPPPEASRLFPPFEESPLSPPPEESPLSP 619
Query: 311 PRSPQHWSQEPRTQP--GPPLESTFHQSLETDTL 342
P S P P PP ES E L
Sbjct: 620 PPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRL 653
Score = 54.7 bits (130), Expect = 2e-07
Identities = 62/192 (32%), Positives = 75/192 (39%), Gaps = 20/192 (10%)
Query: 164 SPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQ 223
SP P E P P PPE E S PE +RLS + P + + +
Sbjct: 543 SPLSPPFEESPLSP--PPE-----ELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPE 595
Query: 224 MRRARSPDLFTPLSRPP--SPLSLPRPRSAPARRPPAPSGDTAPPAR-PHTP------LS 274
R P +PLS PP SPLS P P ++ PP S + PP P +P LS
Sbjct: 596 ASRLFPPFEESPLSPPPEESPLS-PPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLS 654
Query: 275 RIDVRPPLDWGPQRQTLSRPPTPR-RGPPSEAGGGKPPRSPQHWSQEPRTQPG--PPLES 331
+ V L P+ LS PP PP EA PP S P P PP +S
Sbjct: 655 PLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDS 714
Query: 332 TFHQSLETDTLL 343
LE LL
Sbjct: 715 LMSLPLEESPLL 726
Score = 52.0 bits (123), Expect = 2e-06
Identities = 57/187 (30%), Positives = 70/187 (37%), Gaps = 27/187 (14%)
Query: 164 SPARPQPGEGPGGPGGPPEVSR----GEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLH 219
SP P P E P P PPE SR EE +S PE + +S RL P + L
Sbjct: 552 SPLSPPPEELPTSP--PPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLS 609
Query: 220 SGLQMRRARSPDLFTPLSRPPSPLSL-PRPRSAPARRPPAPSGDTAPPARPHTPLSRIDV 278
P +PLS PP L P P +P PP S + PP LS + V
Sbjct: 610 P---------PPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSR--LSPLPV 658
Query: 279 RPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQP-GPPLESTFHQSL 337
L P+ LS PP E PP S P P PP E +
Sbjct: 659 VSRLSPPPEESPLS--------PPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPP 710
Query: 338 ETDTLLT 344
D+L++
Sbjct: 711 PEDSLMS 717
Score = 46.6 bits (109), Expect = 6e-05
Identities = 58/187 (31%), Positives = 70/187 (37%), Gaps = 41/187 (21%)
Query: 164 SPARPQPGEGPGGPGGPPEVSR-------------GEEGRISESPEVTRLSRGRGRPRLL 210
SP P P E P P PPE SR EE +S PEV+RLS RL
Sbjct: 606 SPLSPPPEESPLSP--PPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLS 663
Query: 211 TPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSL-PRPRSAPARRPPAPSGDTAPPAR- 268
P + L P +P S PP L P P +P PP S +PP
Sbjct: 664 PPPEESPLSP---------PPEESPTSPPPEASRLSPPPEDSPTSPPPEDS-PASPPPED 713
Query: 269 -------PHTPLSRIDVRPPLDWGPQRQTLS-RPPTPRRGPPSEAGGGKPPRSPQHWSQE 320
+PL + P L + LS RP P P E +P SPQ ++E
Sbjct: 714 SLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPE----EPHLSPQ--AEE 767
Query: 321 PRTQPGP 327
P P P
Sbjct: 768 PHLSPQP 774
Score = 42.7 bits (99), Expect = 0.001
Identities = 54/176 (30%), Positives = 69/176 (39%), Gaps = 42/176 (23%)
Query: 162 PRSPAR----PQPGEGPGGPGGPPEVSRGEEGRISES-PE-------------------- 196
P SPAR P+ GE G PGG +G EG+ ++ P+
Sbjct: 4820 PESPARAGTEPKKGEAEG-PGGK---EKGLEGKSPDTGPDWLKQFDAVLPGYTLKSQLDI 4875
Query: 197 VTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRP 256
++ L + P T T S L +R+ +P P S PPSPL+ P P S P
Sbjct: 4876 LSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEP-SPPPSPLA-PSPASPPTE-- 4931
Query: 257 PAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPR 312
P T P A P P PL P+ S P PR PP E +PPR
Sbjct: 4932 PLVELPTEPLAEPPVPSPL-----PLASSPE----SARPKPRARPPEEGEDSRPPR 4978
Score = 41.2 bits (95), Expect = 0.003
Identities = 41/115 (35%), Positives = 47/115 (40%), Gaps = 14/115 (12%)
Query: 235 PLSRPP--SPLSLPRPRSAPARRPPAPSGDTAPPAR-PHTPL------SRIDVRPPLDWG 285
PL PP SPLS P P +P PP S + PP P +PL SR PL
Sbjct: 439 PLLPPPEESPLS-PPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPP 497
Query: 286 PQRQTLSRPPTPRRGPPSEAGGGKPP-RSPQHWSQEPRTQPGP---PLESTFHQS 336
P+ LS PP P E PP SP + E P P PL F +S
Sbjct: 498 PEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEES 552
Score = 39.7 bits (91), Expect = 0.008
Identities = 63/224 (28%), Positives = 88/224 (39%), Gaps = 67/224 (29%)
Query: 157 DDYGQPRSP-----ARPQ-PGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLL 210
D + +PR P A P+ PG G GG P +S G ++ EV + G P
Sbjct: 2242 DPFLKPRCPSLDNLAVPESPGVG-GGKASEPLLSPPPFGESRKALEVKKEELGASSPSYG 2300
Query: 211 TP------SPTTDLH-SGLQMRRARSPDLF-TPLS---------------RP-------- 239
P SP++ H GL+++ +PD+F PL+ RP
Sbjct: 2301 PPNLGFVDSPSSGTHLGGLELK---TPDVFKAPLTPRASQVEPQSPGLGLRPQEPPPAQA 2357
Query: 240 --PSPLSLP-------------RPRSAPARRPPAPSGDTAPPAR--PHTPLSRIDVRPPL 282
PSP S P +P P +PP P A P R P P SR+
Sbjct: 2358 LAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPA---- 2413
Query: 283 DWGPQRQTLSRPP-TPRRGPPSEAGGGKPPRSPQHWSQEPRTQP 325
PQ Q+ S+ P TPR P S P +P+ S +P ++P
Sbjct: 2414 --SPQSQSSSQSPLTPR--PLSAEAFCPSPVTPRFQSPDPYSRP 2453
Score = 39.3 bits (90), Expect = 0.010
Identities = 35/107 (32%), Positives = 38/107 (35%), Gaps = 8/107 (7%)
Query: 472 PQKPPPHTEPDSPSP----VLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLAS 527
P PPP P SP P + E LPE+L LS P E+ PP
Sbjct: 448 PLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLE-ESPLSPPPEESPLSPP 506
Query: 528 PHLGLGSPRVSRASSPEGRHLPSPQLGT---KSKEHHPLLADFRRSP 571
P SP SP PSP L T E PL F SP
Sbjct: 507 PESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESP 553
Score = 39.3 bits (90), Expect = 0.010
Identities = 76/351 (21%), Positives = 136/351 (38%), Gaps = 70/351 (19%)
Query: 222 LQMRRARSPDLFTPLSRPPSPLSLPRPRSAPA--------RRPPAPSGDTAPPARPHTPL 273
+Q ++ + P + T + P P L P S + P P G P +
Sbjct: 3753 IQQQQQQGPGVQTNQALGPKPQGLMPPSSHQGLLVQQLSPQPPQGPQGMLGP-----AQV 3807
Query: 274 SRIDVRPPLDWGPQ----------RQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRT 323
+ + + P GPQ + LS P ++G G + + Q Q+
Sbjct: 3808 AVLQQQHPGALGPQGPHRQVLMTQSRVLSSPQLAQQG--QGLMGHRLVTAQQQQQQQQHQ 3865
Query: 324 QPGPPLE-STFHQSLETDTLLTKLCGQD-------RLLRRLQEEIDQKQEEKEQLEAALE 375
Q G S QSL + + KL Q + ++LQ++ +Q++++QL+ +
Sbjct: 3866 QQGSMAGLSHLQQSLMSHSGQPKLSAQPMGSLQQLQQQQQLQQQQQLQQQQQQQLQQQQQ 3925
Query: 376 LTRQQLGQATREAGAPGRAWGRQRLLQDRLVSVRATLCHLTQERERVWDTY--SGLEQEL 433
L +QQL Q ++ Q+L Q + ++ L Q++++ + +Q++
Sbjct: 3926 LQQQQLQQQQQQ----------QQLQQQQQQQLQQQQQQLQQQQQQQQQQFQQQQQQQQM 3975
Query: 434 GTLRETLEYLLHLGSPQDRVSAQQQLWMVEDTLAGLGGPQKPPPH-TEPDSPSPVLQGEE 492
G L ++ L SPQ QQQ + G G P KP H + P + P L
Sbjct: 3976 GLLNQSRTLL----SPQQ----QQQ----QQVALGPGMPAKPLQHFSSPGALGPTLL-LT 4022
Query: 493 SSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLGLGSPRVSRASSP 543
E+ ++ ++ + P T G P L +G+ S A+ P
Sbjct: 4023 GKEQNTVDPAVSSEATEGPSTHQGGP-----------LAIGTTPESMATEP 4062
Score = 38.5 bits (88), Expect = 0.017
Identities = 50/180 (27%), Positives = 64/180 (35%), Gaps = 24/180 (13%)
Query: 153 RAEGDDYGQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRL--- 209
R+EG P RP+ P P + EE +S PE L P L
Sbjct: 737 RSEG-----PHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQ 791
Query: 210 -----LTPSPTTDLHSGLQMRRAR-SPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDT 263
L+P P +LH Q SP P P S P+S P P
Sbjct: 792 AEGPHLSPQPE-ELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESH 850
Query: 264 APPARPHTPLSRIDVRPPLDWG----PQRQTLSRPP-----TPRRGPPSEAGGGKPPRSP 314
P PLS +PP + G P+ L PP +P G P+ + G+PP SP
Sbjct: 851 LSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSP 910
Score = 38.1 bits (87), Expect = 0.023
Identities = 50/193 (25%), Positives = 66/193 (34%), Gaps = 32/193 (16%)
Query: 157 DDYGQPRSPARPQPGEGPGGPGGPPEVSRGEE-GRISESPEVTRLSRGRGRPRLLT---- 211
D Y QP RPQP PP + R+ SP+ S+ PR L+
Sbjct: 2376 DPYAQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAF 2435
Query: 212 -PSPTTDLHSGLQM-----RRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAP 265
PSP T R +S D F PL +PP P A + + P
Sbjct: 2436 CPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPPRPQPPEVAFKAGSLAHTSLGAGGFP 2495
Query: 266 PARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWS------- 318
A P P + + P +PP R P + A G P SP ++
Sbjct: 2496 AALPAGPAGELHAKVP---------SGQPPNFVRSPGTGAFVGTP--SPMRFTFPQAVGE 2544
Query: 319 ---QEPRTQPGPP 328
+ P QPG P
Sbjct: 2545 PSLKPPVPQPGLP 2557
Score = 37.0 bits (84), Expect = 0.050
Identities = 67/278 (24%), Positives = 92/278 (33%), Gaps = 46/278 (16%)
Query: 148 LGRASRAEGDDYGQPRSPARPQPGEGPGGPGGP-PEVSRGEEGRIS-ESPEVTRLSRGRG 205
LG +S + G+ YG SP RP P P G P +S G R SP R G G
Sbjct: 2594 LGPSSGSTGESYGL--SPLRPPSVLPPPAPDGSLPYLSHGASQRSGITSPVEKREDPGTG 2651
Query: 206 RPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRP----PAPSG 261
G + A P P S L + R R
Sbjct: 2652 M--------------GSSLATAELPGTQDPGMSGLSQTELEKQRQRQRLRELLIRQQIQR 2697
Query: 262 DTAPPARPHTPLSRIDVRPPLDWG-----PQRQTLSRPPTPRRG----------PPSEAG 306
+T + + V PP WG P + LSR TP G PPS+
Sbjct: 2698 NTLRQEKETAAAAAGAVGPPGSWGAEPSSPAFEQLSRGQTPFAGTQDKSSLVGLPPSKLS 2757
Query: 307 GGKPPRSPQHWSQEPRTQPGPPLESTFHQSLETDTLLTKLCGQDRLLRRLQEE----IDQ 362
G P P + + R PP + + + L+ G +R + Q
Sbjct: 2758 G--PILGPGSFPSDDRLSRPPPPATPSSMDVNSRQLVG---GSQAFYQRAPYPGSLPLQQ 2812
Query: 363 KQEEKEQLEAALELTRQQLGQATREAGAPGRAWGRQRL 400
+Q++ Q + A T + + R PG GRQ L
Sbjct: 2813 QQQQLWQQQQATAATSMRFAMSARFPSTPGPELGRQAL 2850
Score = 36.2 bits (82), Expect = 0.086
Identities = 34/115 (29%), Positives = 44/115 (38%), Gaps = 8/115 (6%)
Query: 157 DDYGQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTT 216
D Y +P P+RPQ + PP E + S T L G G P L P
Sbjct: 2448 DPYSRP--PSRPQSRDPFAPLHKPPRPQPPEVAFKAGSLAHTSLGAG-GFPAALPAGPAG 2504
Query: 217 DLH----SGLQMRRARSPDLFTPLSRP-PSPLSLPRPRSAPARRPPAPSGDTAPP 266
+LH SG RSP + P P + P+ P+ +PP P PP
Sbjct: 2505 ELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPPVPQPGLPPP 2559
Score = 33.9 bits (76), Expect = 0.42
Identities = 36/129 (27%), Positives = 45/129 (34%), Gaps = 33/129 (25%)
Query: 167 RPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRR 226
+PQ G PG GP + E+ R +G PRL P+P L +G +
Sbjct: 4260 QPQLGGFPGPQTGPLQ-------------ELGAGPRPQGPPRL--PAPPGALSTGPVLGP 4304
Query: 227 ARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGP 286
P P SP RP P+ P+ PP P TP P
Sbjct: 4305 VH------PTPPPSSPQEPKRPSQLPSPSSQLPTEAQLPPTHPGTP------------KP 4346
Query: 287 QRQTLSRPP 295
Q TL PP
Sbjct: 4347 QGPTLEPPP 4355
Score = 33.5 bits (75), Expect = 0.55
Identities = 40/115 (34%), Positives = 45/115 (39%), Gaps = 15/115 (13%)
Query: 472 PQKPPPHTEPDSP----SPVLQGEES--SERESLPESLELSSPRS--PETDWGRPPGGDK 523
P PPP P SP SP EES S E P S L +P S PE PP +
Sbjct: 493 PLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEES 552
Query: 524 DLASPHLGLGS---PRVSRASSP--EGRHLPSPQLGTKS--KEHHPLLADFRRSP 571
L+ P L + P SR S P E P P+ S E L F SP
Sbjct: 553 PLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESP 607
Score = 32.3 bits (72), Expect = 1.2
Identities = 40/162 (24%), Positives = 55/162 (33%), Gaps = 24/162 (14%)
Query: 160 GQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLH 219
G+P P P P E P P G P +S P ++ + P L SP +L
Sbjct: 904 GEP--PLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPAL---SPLGELE 958
Query: 220 SGLQMRRARSPD-------LFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTP 272
+ P+ L TP+S PP P PP+P P P +P
Sbjct: 959 YPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGS----PVGPASP 1014
Query: 273 LSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSP 314
+ + P L P+ PPS+ PP P
Sbjct: 1015 ILMEPLPPQCS-----PLLQHSLVPQNSPPSQC---SPPALP 1048
Score = 31.6 bits (70), Expect = 2.1
Identities = 39/137 (28%), Positives = 46/137 (33%), Gaps = 42/137 (30%)
Query: 472 PQKPPPHTEPDSPSPVLQGEESSERESLPESLELS-----SPRSPETDWGR--------- 517
P PPP P SP P E+S PE +S SP SP + R
Sbjct: 553 PLSPPPEELPTSPPP-----EASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESP 607
Query: 518 --PPGGDKDLASPHLGLGSPRVSRASSP-----------EGRHLPSPQLGTKSKEHHPLL 564
PP + L+ P P SR S P E P P++ S PL
Sbjct: 608 LSPPPEESPLSPP------PEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLS----PLP 657
Query: 565 ADFRRSPGAGSQPLPSP 581
R SP PL P
Sbjct: 658 VVSRLSPPPEESPLSPP 674
Score = 31.6 bits (70), Expect = 2.1
Identities = 30/95 (31%), Positives = 34/95 (35%), Gaps = 13/95 (13%)
Query: 472 PQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGR--PPGGDKDLASPH 529
P PPP SP PV+ ES SP SP + R PP D + P
Sbjct: 643 PMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPP- 701
Query: 530 LGLGSPRVSRASSPEGRHLPSPQLGTKSKEHHPLL 564
P S AS P P L + E PLL
Sbjct: 702 -----PEDSPASPP-----PEDSLMSLPLEESPLL 726
Score = 30.4 bits (67), Expect = 4.7
Identities = 34/116 (29%), Positives = 41/116 (35%), Gaps = 18/116 (15%)
Query: 472 PQKPPPHTEPDSP----SPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLAS 527
P PPP P SP SP+ E PE+ LS P PE PP + ++
Sbjct: 535 PLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRLSPP--PEESPMSPPPEESPMSP 592
Query: 528 PHLGLGSPRVSRASSP--EGRHLPSPQLGTKSKEHHPLLADFRRSPGAGSQPLPSP 581
P P SR P E P P+ S P R SP P+ P
Sbjct: 593 P------PEASRLFPPFEESPLSPPPEESPLS----PPPEASRLSPPPEDSPMSPP 638
>gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1
preproprotein [Homo sapiens]
Length = 331
Score = 56.6 bits (135), Expect = 6e-08
Identities = 58/191 (30%), Positives = 78/191 (40%), Gaps = 28/191 (14%)
Query: 149 GRASRAEGDDYGQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPR 208
G SR+ G+P+ P PQ G P GP PP +G + + P+ G+P+
Sbjct: 145 GDKSRSPRSPPGKPQGPP-PQGGNQPQGPPPPPGKPQGPPPQGGKKPQGPPPP---GKPQ 200
Query: 209 LLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRP--PAPSGDTAP- 265
P P D + R ++SP P PP + P+ P +P P P G P
Sbjct: 201 --GPPPQGD-----KSRSSQSPP-GKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQ 252
Query: 266 -PARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGG---GKPP---RSPQHWS 318
P P P PP G + Q+ PP +GPP + G G PP +PQ
Sbjct: 253 GPPPPGKPQG-----PPAQGGSKSQSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQ 307
Query: 319 QEPRTQP-GPP 328
P QP GPP
Sbjct: 308 APPAGQPQGPP 318
Score = 52.8 bits (125), Expect = 9e-07
Identities = 56/191 (29%), Positives = 72/191 (37%), Gaps = 47/191 (24%)
Query: 160 GQPRSPA-----RPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSP 214
G+P+ P RPQ PG P GPP +G++ R SP G+P+ P P
Sbjct: 116 GKPQGPPPQGGNRPQGPPPPGKPQGPPP--QGDKSRSPRSPP--------GKPQ--GPPP 163
Query: 215 TTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPAR-RPPAPSGDTA-----PPAR 268
G + P P PP P+ P + + P P GD + PP +
Sbjct: 164 -----QGGNQPQGPPPPPGKPQGPPPQGGKKPQGPPPPGKPQGPPPQGDKSRSSQSPPGK 218
Query: 269 PHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAG----GGKPPRSPQ-------HW 317
P P P G Q Q PP +GPP + G G PP PQ
Sbjct: 219 PQGP--------PPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPAQGGSK 270
Query: 318 SQEPRTQPGPP 328
SQ R+ PG P
Sbjct: 271 SQSARSPPGKP 281
Score = 52.8 bits (125), Expect = 9e-07
Identities = 44/157 (28%), Positives = 62/157 (39%), Gaps = 12/157 (7%)
Query: 162 PRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLS---RGRGRPRLLTPSPTTDL 218
P+ +PQ PG P GPP +G++ R S+SP +G +P+ P P
Sbjct: 184 PQGGKKPQGPPPPGKPQGPPP--QGDKSRSSQSPPGKPQGPPPQGGNQPQ--GPPPPPGK 239
Query: 219 HSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDV 278
G + P P +P P + +S AR PP P P +
Sbjct: 240 PQGPPPQGGNKPQGPPPPGKPQGPPAQGGSKSQSARSPPGK-----PQGPPQQEGNNPQG 294
Query: 279 RPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQ 315
PP G +Q + P +GPP GG+P R PQ
Sbjct: 295 PPPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRPPQ 331
Score = 49.7 bits (117), Expect = 7e-06
Identities = 48/167 (28%), Positives = 64/167 (38%), Gaps = 34/167 (20%)
Query: 160 GQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLH 219
G P+ P+ PQ G P GP PP +G + P+ G+P+ P P D
Sbjct: 34 GNPQGPS-PQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPPPP---GKPQ--GPPPQGD-- 85
Query: 220 SGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVR 279
++RSP PP +P+ P + P G PP +P P
Sbjct: 86 ------KSRSP------RSPPG-----KPQGPPPQGGNQPQGPPPPPGKPQGP------- 121
Query: 280 PPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQPG 326
PP G R PP +GPP + + PRSP Q P Q G
Sbjct: 122 PP--QGGNRPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGG 166
Score = 40.8 bits (94), Expect = 0.003
Identities = 33/111 (29%), Positives = 41/111 (36%), Gaps = 12/111 (10%)
Query: 472 PQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLG 531
PQ PPP +P P P QG++S S P + P+ G PP K P G
Sbjct: 68 PQGPPPPGKPQGPPP--QGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG 125
Query: 532 LGSPRVSRASSPEGRHLPSPQLGTKSKEHHPLLADFRRSPGAGSQPLPSPG 582
P + P G+ P G KS+ R PG P P G
Sbjct: 126 GNRP---QGPPPPGKPQGPPPQGDKSRSP-------RSPPGKPQGPPPQGG 166
Score = 39.7 bits (91), Expect = 0.008
Identities = 35/115 (30%), Positives = 44/115 (38%), Gaps = 9/115 (7%)
Query: 472 PQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLG 531
PQ PPP +P P P QG++S S P + P+ G PP K P G
Sbjct: 129 PQGPPPPGKPQGPPP--QGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG 186
Query: 532 LGSPRVSRASSPEGRHLPSPQLGTKSK-EHHPLLADFRRSPGAGSQPL---PSPG 582
P + P G+ P G KS+ P P G+QP P PG
Sbjct: 187 GKKP---QGPPPPGKPQGPPPQGDKSRSSQSPPGKPQGPPPQGGNQPQGPPPPPG 238
Score = 38.1 bits (87), Expect = 0.023
Identities = 28/88 (31%), Positives = 38/88 (43%), Gaps = 6/88 (6%)
Query: 472 PQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLG 531
PQ PPP +P P P QG++S +S P + P+ G PP K P G
Sbjct: 190 PQGPPPPGKPQGPPP--QGDKSRSSQSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG 247
Query: 532 LGSPR-VSRASSPEGRHLPSPQLGTKSK 558
P+ P+G P Q G+KS+
Sbjct: 248 GNKPQGPPPPGKPQG---PPAQGGSKSQ 272
Score = 33.1 bits (74), Expect = 0.72
Identities = 28/102 (27%), Positives = 40/102 (39%), Gaps = 18/102 (17%)
Query: 236 LSRPPSP-LSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRP 294
+S+ SP L P+ + P G PP +P P + +P GP P
Sbjct: 23 VSQEESPSLIAGNPQGPSPQGGNKPQGPPPPPGKPQGPPPQGGNKPQ---GPP------P 73
Query: 295 PTPRRGPPSEAGGGKPPRSPQHWSQ--------EPRTQPGPP 328
P +GPP + + PRSP Q +P+ P PP
Sbjct: 74 PGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPP 115
>gi|14602439 Williams Beuren syndrome chromosome region 14 isoform
delta [Homo sapiens]
Length = 831
Score = 56.2 bits (134), Expect = 8e-08
Identities = 77/257 (29%), Positives = 102/257 (39%), Gaps = 36/257 (14%)
Query: 145 LRALGRASRAEGDDYGQPRS-PARPQP-GEGPGGPGGPPEVSRGEEGRISESPEVTRLSR 202
L LG + A G + PR P P P G+ P P + S +P +T+L
Sbjct: 474 LLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLT 533
Query: 203 GRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGD 262
+ L P L S +R SP P P P P P R PP P+
Sbjct: 534 AAKPEQALEPP----LVSSTLLRSPGSPQETVP--EFPCTFLPPTPAPTPPRPPPGPA-- 585
Query: 263 TAPPARPHTPLSRIDVRPPLDWGPQRQT---LSRPPTP-----RRGPPSEA-GGGKPP-- 311
T P+RP + PP G +R+ LS P P R PP G+P
Sbjct: 586 TLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDSN 645
Query: 312 --RSPQHWSQEPRTQPGPPLESTFHQSLETDTL---LTKLCGQDRLLRR--LQEEIDQKQ 364
R H S E + + F+ L DTL ++ L Q L R LQEE Q +
Sbjct: 646 KNRRITHISAEQKRR--------FNIKLGFDTLHGLVSTLSAQPSLKERAGLQEEAQQLR 697
Query: 365 EEKEQLEAALELTRQQL 381
+E E+L AA+ L +QQL
Sbjct: 698 DEIEELNAAINLCQQQL 714
Score = 36.2 bits (82), Expect = 0.086
Identities = 31/101 (30%), Positives = 43/101 (42%), Gaps = 7/101 (6%)
Query: 235 PLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRP 294
P + PP+P S+P P P P G + P P + R +PP P+ Q S P
Sbjct: 452 PAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPR--GKPPAP-SPRGQKAS-P 507
Query: 295 PT---PRRGPPSEAGGGKPPRSPQHWSQEPRTQPGPPLEST 332
PT PP+ AG P + + +P PPL S+
Sbjct: 508 PTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSS 548
Score = 31.6 bits (70), Expect = 2.1
Identities = 34/109 (31%), Positives = 40/109 (36%), Gaps = 4/109 (3%)
Query: 474 KPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLGLG 533
KP EP S L S +E++PE P +P RPP G LA P L
Sbjct: 536 KPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLA-PSRPLL 594
Query: 534 SPRVSRASSPEGRHLPSPQLGTKSKEHHPLLADFRRSPGAGSQPLPSPG 582
P+ R S P G S P R SP QP+ S G
Sbjct: 595 VPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSP---PQPILSRG 640
Score = 30.0 bits (66), Expect = 6.1
Identities = 45/181 (24%), Positives = 61/181 (33%), Gaps = 26/181 (14%)
Query: 157 DDYGQPRSPARPQPGEGPGGPGGPPEV-SRGEEGRISE-----SPEVTRLS-RGRGRPRL 209
D + R P P P P P P V S G + S +T LS R + R
Sbjct: 301 DFFTNSRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARN 360
Query: 210 LTPSPTTD---LHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPP 266
P P L S + P L PP P+ P P + P PP
Sbjct: 361 SCPGPLDSSAFLSSDFLLPEDPKPRL------PPPPVPPPLLHYPPPAKVPGLEPCPPPP 414
Query: 267 ARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQPG 326
P P + + PL + P+ + PP P G P +P + P++ P
Sbjct: 415 FPPMAPPTALLQEEPL-FSPRFPFPTVPPAP---------GVSPLPAPAAFPPTPQSVPS 464
Query: 327 P 327
P
Sbjct: 465 P 465
>gi|14602435 Williams Beuren syndrome chromosome region 14 isoform
beta [Homo sapiens]
Length = 833
Score = 55.8 bits (133), Expect = 1e-07
Identities = 74/252 (29%), Positives = 101/252 (40%), Gaps = 24/252 (9%)
Query: 145 LRALGRASRAEGDDYGQPRS-PARPQP-GEGPGGPGGPPEVSRGEEGRISESPEVTRLSR 202
L LG + A G + PR P P P G+ P P + S +P +T+L
Sbjct: 474 LLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLT 533
Query: 203 GRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGD 262
+ L P L S +R SP P P P P P R PP P+
Sbjct: 534 AAKPEQALEPP----LVSSTLLRSPGSPQETVP--EFPCTFLPPTPAPTPPRPPPGPA-- 585
Query: 263 TAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRS------PQH 316
T P+RP + PP G +R+ LS + GP + + PP+ P
Sbjct: 586 TLAPSRPLLVPKAERLSPPAPSGSERR-LSGDLSSMPGPGTLSVRVSPPQPILSRGRPDS 644
Query: 317 WSQEPR--TQPGPPLESTFHQSLETDTL---LTKLCGQDRLLRR--LQEEIDQKQEEKEQ 369
E R T + F+ L DTL ++ L Q L R LQEE Q ++E E+
Sbjct: 645 NKTENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSLKERAGLQEEAQQLRDEIEE 704
Query: 370 LEAALELTRQQL 381
L AA+ L +QQL
Sbjct: 705 LNAAINLCQQQL 716
Score = 36.2 bits (82), Expect = 0.086
Identities = 31/101 (30%), Positives = 43/101 (42%), Gaps = 7/101 (6%)
Query: 235 PLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRP 294
P + PP+P S+P P P P G + P P + R +PP P+ Q S P
Sbjct: 452 PAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPR--GKPPAP-SPRGQKAS-P 507
Query: 295 PT---PRRGPPSEAGGGKPPRSPQHWSQEPRTQPGPPLEST 332
PT PP+ AG P + + +P PPL S+
Sbjct: 508 PTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSS 548
Score = 31.6 bits (70), Expect = 2.1
Identities = 34/109 (31%), Positives = 40/109 (36%), Gaps = 4/109 (3%)
Query: 474 KPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLGLG 533
KP EP S L S +E++PE P +P RPP G LA P L
Sbjct: 536 KPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLA-PSRPLL 594
Query: 534 SPRVSRASSPEGRHLPSPQLGTKSKEHHPLLADFRRSPGAGSQPLPSPG 582
P+ R S P G S P R SP QP+ S G
Sbjct: 595 VPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSP---PQPILSRG 640
Score = 30.0 bits (66), Expect = 6.1
Identities = 45/181 (24%), Positives = 61/181 (33%), Gaps = 26/181 (14%)
Query: 157 DDYGQPRSPARPQPGEGPGGPGGPPEV-SRGEEGRISE-----SPEVTRLS-RGRGRPRL 209
D + R P P P P P P V S G + S +T LS R + R
Sbjct: 301 DFFTNSRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARN 360
Query: 210 LTPSPTTD---LHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPP 266
P P L S + P L PP P+ P P + P PP
Sbjct: 361 SCPGPLDSSAFLSSDFLLPEDPKPRL------PPPPVPPPLLHYPPPAKVPGLEPCPPPP 414
Query: 267 ARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQPG 326
P P + + PL + P+ + PP P G P +P + P++ P
Sbjct: 415 FPPMAPPTALLQEEPL-FSPRFPFPTVPPAP---------GVSPLPAPAAFPPTPQSVPS 464
Query: 327 P 327
P
Sbjct: 465 P 465
>gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Homo
sapiens]
Length = 1034
Score = 54.7 bits (130), Expect = 2e-07
Identities = 29/93 (31%), Positives = 50/93 (53%), Gaps = 6/93 (6%)
Query: 59 GWLHKQDSSGL---RLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPR 115
GWL K+ + + WK+ WFVL L++Y + +E G + LP + I D R
Sbjct: 575 GWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKI--DRASECR 632
Query: 116 GRRFTFTAEHPGMRTYVLAADTLEDLRGWLRAL 148
+++ F A HP ++++ AA+ L+D+ WL +
Sbjct: 633 -KKYAFKACHPKIKSFYFAAEHLDDMNRWLNRI 664
>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
Length = 416
Score = 53.9 bits (128), Expect = 4e-07
Identities = 55/180 (30%), Positives = 73/180 (40%), Gaps = 27/180 (15%)
Query: 160 GQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLH 219
G+P+ P PQ G P GP PP +G + P+ G+P+ P P
Sbjct: 240 GKPQGPP-PQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPP---GKPQ--GPPP----Q 289
Query: 220 SGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRP--PAPSGDTAP--PARPHTPLSR 275
G + R +RSP P PP + P+ P +P P P G P P P P
Sbjct: 290 GGSKSRSSRSPP-GKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQG- 347
Query: 276 IDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGG---GKPP---RSPQHWSQEPRTQP-GPP 328
PP G + ++ PP +GPP + G G PP +PQ P QP GPP
Sbjct: 348 ----PPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQPQGPP 403
Score = 53.1 bits (126), Expect = 7e-07
Identities = 61/211 (28%), Positives = 80/211 (37%), Gaps = 42/211 (19%)
Query: 149 GRASRAEGDDYGQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPR 208
G SR+ G+P+ P PQ G P GP PP +G + P+ G+P+
Sbjct: 105 GDKSRSPRSPPGKPQGPP-PQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPP---GKPQ 160
Query: 209 LLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRP--PAPSGDTAP- 265
P P D S R +RSP P PP + P+ P +P P P G P
Sbjct: 161 --GPPPQGDNKS----RSSRSPP-GKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQ 213
Query: 266 ----PARPHTPLSRIDVR-------------PPLDWGPQRQTLSRPPTPRRGPPSEAG-- 306
P +P P + D + PP G Q Q PP +GPP + G
Sbjct: 214 GPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNK 273
Query: 307 --GGKPPRSPQ-------HWSQEPRTQPGPP 328
G PP PQ S+ R+ PG P
Sbjct: 274 PQGPPPPGKPQGPPPQGGSKSRSSRSPPGKP 304
Score = 49.7 bits (117), Expect = 7e-06
Identities = 46/164 (28%), Positives = 61/164 (37%), Gaps = 16/164 (9%)
Query: 160 GQPRSPA-----RPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLS---RGRGRPRLLT 211
G+P+ P +PQ PG P GPP G + R S SP +G +P+
Sbjct: 261 GKPQGPPPQGGNKPQGPPPPGKPQGPPPQG-GSKSRSSRSPPGKPQGPPPQGGNQPQ--G 317
Query: 212 PSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHT 271
P P G + P P +P P +S AR PP P P
Sbjct: 318 PPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGK-----PQGPPQQ 372
Query: 272 PLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQ 315
+ PP G +Q + P +GPP GG+P R PQ
Sbjct: 373 EGNNPQGPPPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRPPQ 416
Score = 48.9 bits (115), Expect = 1e-05
Identities = 58/211 (27%), Positives = 76/211 (36%), Gaps = 44/211 (20%)
Query: 160 GQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGR---------GRPRLL 210
G P+ A PQ G P GP PP +G + P+ G+ +P+
Sbjct: 34 GNPQG-APPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGP 92
Query: 211 TP--SPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRP--PAPSGDT--- 263
P P G + R RSP P PP + P+ P +P P P G
Sbjct: 93 PPPGKPQGPPPQGDKSRSPRSPP-GKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQ 151
Query: 264 --APPARPHTPLSRIDVR-------------PPLDWGPQRQTLSRPPTPRRGPPSEAG-- 306
PP +P P + D + PP G Q Q PP +GPP + G
Sbjct: 152 GPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNK 211
Query: 307 --GGKPPRSPQ-------HWSQEPRTQPGPP 328
G PP PQ + SQ R+ PG P
Sbjct: 212 PQGPPPPGKPQGPPPQGDNKSQSARSPPGKP 242
Score = 46.2 bits (108), Expect = 8e-05
Identities = 47/194 (24%), Positives = 63/194 (32%), Gaps = 35/194 (18%)
Query: 160 GQPRSPA-----RPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSP 214
G+P+ P +PQ PG P GPP + P + +G + P P
Sbjct: 199 GKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPP 258
Query: 215 TTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPA------------PSGD 262
G + P P +P P +S +R PP P G
Sbjct: 259 PPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGP 318
Query: 263 TAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGG---------GKPPRS 313
PP +P P P G + Q P P+ GPP + G GKP
Sbjct: 319 PPPPGKPQGP--------PPQGGNKPQGPPPPGKPQ-GPPPQGGSKSRSARSPPGKPQGP 369
Query: 314 PQHWSQEPRTQPGP 327
PQ P+ P P
Sbjct: 370 PQQEGNNPQGPPPP 383
Score = 45.4 bits (106), Expect = 1e-04
Identities = 51/190 (26%), Positives = 73/190 (38%), Gaps = 37/190 (19%)
Query: 160 GQPRSPARPQ--PGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGR-GRPRLLTPSPTT 216
G P P +PQ P +G P GPP + +G + ++ +R G+P+ P P
Sbjct: 193 GPPPPPGKPQGPPPQGGNKPQGPPPPGK-PQGPPPQGDNKSQSARSPPGKPQ--GPPP-- 247
Query: 217 DLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPAR-RPPAPSGDT------APPARP 269
G + P P PP + P+ P + + P P G + +PP +P
Sbjct: 248 ---QGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKP 304
Query: 270 HTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAG----GGKPPRSPQ-------HWS 318
PP G Q Q PP +GPP + G G PP PQ S
Sbjct: 305 Q--------GPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKS 356
Query: 319 QEPRTQPGPP 328
+ R+ PG P
Sbjct: 357 RSARSPPGKP 366
Score = 45.1 bits (105), Expect = 2e-04
Identities = 34/104 (32%), Positives = 44/104 (42%), Gaps = 19/104 (18%)
Query: 236 LSRPPSP-LSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRP 294
+S+ SP L P+ AP + P G +PP +P PP G Q Q P
Sbjct: 23 VSQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQ--------GPPPQGGNQPQGPPPP 74
Query: 295 PTPRRGPPSEAG----GGKPPRSPQ------HWSQEPRTQPGPP 328
P +GPP + G G PP PQ S+ PR+ PG P
Sbjct: 75 PGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKP 118
Score = 40.0 bits (92), Expect = 0.006
Identities = 34/112 (30%), Positives = 42/112 (37%), Gaps = 13/112 (11%)
Query: 472 PQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLG 531
PQ PPP +P P P QG++S S P + P+ G PP K P G
Sbjct: 89 PQGPPPPGKPQGPPP--QGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG 146
Query: 532 LGSPR-VSRASSPEGRHLPSPQLGTKSKEHHPLLADFRRSPGAGSQPLPSPG 582
P+ P+G P PQ KS+ R PG P P G
Sbjct: 147 GNKPQGPPPPGKPQG---PPPQGDNKSRSS-------RSPPGKPQGPPPQGG 188
Score = 37.0 bits (84), Expect = 0.050
Identities = 28/88 (31%), Positives = 36/88 (40%), Gaps = 5/88 (5%)
Query: 472 PQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLG 531
PQ PPP +P P P G +S S P + P+ G PP K P G
Sbjct: 274 PQGPPPPGKPQGPPP-QGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG 332
Query: 532 LGSPR-VSRASSPEGRHLPSPQLGTKSK 558
P+ P+G P PQ G+KS+
Sbjct: 333 GNKPQGPPPPGKPQG---PPPQGGSKSR 357
Score = 35.0 bits (79), Expect = 0.19
Identities = 34/113 (30%), Positives = 42/113 (37%), Gaps = 14/113 (12%)
Query: 472 PQKPPPHTEPDSPSPVLQGE-ESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHL 530
PQ PPP +P P P QG+ +S S P + P+ G PP K P
Sbjct: 150 PQGPPPPGKPQGPPP--QGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQ 207
Query: 531 GLGSPR-VSRASSPEGRHLPSPQLGTKSKEHHPLLADFRRSPGAGSQPLPSPG 582
G P+ P+G P PQ KS+ R PG P P G
Sbjct: 208 GGNKPQGPPPPGKPQG---PPPQGDNKSQ-------SARSPPGKPQGPPPQGG 250
>gi|237757312 synaptojanin 1 isoform c [Homo sapiens]
Length = 1295
Score = 53.5 bits (127), Expect = 5e-07
Identities = 47/140 (33%), Positives = 65/140 (46%), Gaps = 22/140 (15%)
Query: 207 PRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLP-RPRSAPARRPPAPSGDTAP 265
P+ L PS ++ L + SP +S P P SLP RP AP+R P PS ++P
Sbjct: 1027 PQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVP-SLPIRPSRAPSRTPGPPSAQSSP 1085
Query: 266 -PARPHTPLSRIDVRPPLDWGPQRQTLSRP------PTPRRGPPSEAGGGKP-------- 310
A+P TPL + D PL+ P+R RP P P + PP +G P
Sbjct: 1086 IDAQPATPLPQKDPAQPLE--PKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFG 1143
Query: 311 -PRSPQHWSQE--PRTQPGP 327
P+SP ++ R+QP P
Sbjct: 1144 APKSPGTTRKDNIGRSQPSP 1163
Score = 32.0 bits (71), Expect = 1.6
Identities = 51/201 (25%), Positives = 64/201 (31%), Gaps = 33/201 (16%)
Query: 158 DYGQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLT------ 211
D QP P RP P P P R + SP TR G + T
Sbjct: 1098 DPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKSPGTTRKDNIG 1157
Query: 212 ---PSPTTDL----HSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTA 264
PSP L +G R P +S P S R++ R P T+
Sbjct: 1158 RSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQS-----HARASAGRLTPESQSKTS 1212
Query: 265 PPARPHT----PLSRIDVRPP-LDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQ 319
++ T PL PP P Q L P P P ++G PQ
Sbjct: 1213 ETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSG-------PQ---P 1262
Query: 320 EPRTQPGPPLESTFHQSLETD 340
T P PP S SL ++
Sbjct: 1263 NLETPPQPPPRSRSSHSLPSE 1283
Score = 30.8 bits (68), Expect = 3.6
Identities = 33/119 (27%), Positives = 45/119 (37%), Gaps = 10/119 (8%)
Query: 472 PQKPPPHTEPDSPSPVLQ--GEESSERESLPESLELSSPRSPETDWGRP-PGG---DKDL 525
PQ+PPP + SP+P + G S + +++ S P SP+ P P G +
Sbjct: 1123 PQRPPPPSGARSPAPTRKEFGAPKSPGTTRKDNIGRSQP-SPQAGLAGPGPAGYSTARPT 1181
Query: 526 ASPHLGLGSPRVSRASSPEGRHLPSPQLGTKSKEHHPLLADFRRSPGAGSQP---LPSP 581
P G+ S S A + GR P Q T P A P LP P
Sbjct: 1182 IPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPP 1240
>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
Length = 1094
Score = 53.5 bits (127), Expect = 5e-07
Identities = 54/193 (27%), Positives = 67/193 (34%), Gaps = 38/193 (19%)
Query: 149 GRASRAEGDDYGQPRSPAR-------PQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLS 201
G ++G GQP S PQ G G G P G + I S +++
Sbjct: 429 GSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLS--G 486
Query: 202 RGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPL-----SLPRPRS------ 250
R +L P P L R PD PL PP P LPRP +
Sbjct: 487 RSVSLRKLKRPPPPPRRTHSLHQRGLAVPD--GPLGLPPKPERKQQPQLPRPPTTGGSEG 544
Query: 251 ---APARRPPA--------PSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRR 299
AP PA P G PP P LS P + Q T + PP
Sbjct: 545 AGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLS-----PSSGYSSQSGTPTLPPKGLA 599
Query: 300 GPPSEAGGGKPPR 312
GPP+ G +PP+
Sbjct: 600 GPPASPGKAQPPK 612
Score = 42.4 bits (98), Expect = 0.001
Identities = 44/165 (26%), Positives = 70/165 (42%), Gaps = 21/165 (12%)
Query: 175 GGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRR---ARSPD 231
G PGG P + G + + R GR P P+P++ LH+ ++++ A S
Sbjct: 893 GAPGGAPTPALGPS---APQKPLRRALSGRASP---VPAPSSGLHAAVRLKACSLAASEG 946
Query: 232 LFTPLSRPPSPLSLPRPRSAPARRPP---APSGDTAPPARPHTPLSRIDVRPPLDWGPQR 288
L + P P + PRP +PA + RP +P ++ D++ L +
Sbjct: 947 LSSAQPNGP-PEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRS 1005
Query: 289 QTLSRPP-----TPRRGPP---SEAGGGKPPRSPQHWSQEPRTQP 325
+ RPP +P+ PP + G PP SP + EP T P
Sbjct: 1006 ISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAP 1050
Score = 34.3 bits (77), Expect = 0.32
Identities = 49/193 (25%), Positives = 62/193 (32%), Gaps = 31/193 (16%)
Query: 156 GDDYGQPRSPARPQPGEGPGG------PGGP----PEVSRGEEGRISESPEVTRLSRGRG 205
GD + P P P P P P P P V G SP+
Sbjct: 655 GDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSP------- 707
Query: 206 RPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAP 265
P+P T L + LQ SP + S PPSP P P ++P +
Sbjct: 708 ------PTPQTTL-TPLQ----ESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSA 756
Query: 266 PARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQP 325
PL + PP P+ Q LS P PP EA P S P
Sbjct: 757 SETAEEPLQDPNWPPPPPPAPEEQDLSMADFP---PPEEAFFSVASPEPAGPSGSPELVS 813
Query: 326 GPPLESTFHQSLE 338
P S+ +L+
Sbjct: 814 SPAASSSSATALQ 826
Score = 33.9 bits (76), Expect = 0.42
Identities = 39/133 (29%), Positives = 50/133 (37%), Gaps = 23/133 (17%)
Query: 177 PGGPPEVSRGEEGRISESPEVTR---LSRGRGRPRLLTP-SPTT--DLHSGLQMRRARSP 230
P GPPE E R +SP T S+G + +L P SP T DL L
Sbjct: 952 PNGPPEA----EPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSIS 1007
Query: 231 DLFTPLSRPPSPLSLPRPRSAPARRPPA---PSGDTAPPARPHTPLSRIDVRPPLDWGPQ 287
+ RPP P+ +P PP PS PPA P P + PP + P
Sbjct: 1008 E-----QRPPQA-----PKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGLPH 1057
Query: 288 RQTLSRPPTPRRG 300
Q ++ G
Sbjct: 1058 TQDRTKRELAENG 1070
Score = 32.7 bits (73), Expect = 0.95
Identities = 42/185 (22%), Positives = 69/185 (37%), Gaps = 18/185 (9%)
Query: 164 SPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRL---------SRGRGRPRLLT-PS 213
S +P + P P PP ++ +++ P + G P L++ P+
Sbjct: 757 SETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPA 816
Query: 214 PTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPL 273
++ + LQ++ SPD PP+P + SAP P + ++ P
Sbjct: 817 ASSSSATALQIQPPGSPD------PPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGP- 869
Query: 274 SRIDVRPPLDWGPQRQTLS-RPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQPGPPLEST 332
R DV PL Q + R G P+ A G P+ P + R P P S
Sbjct: 870 PREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSG 929
Query: 333 FHQSL 337
H ++
Sbjct: 930 LHAAV 934
>gi|55770898 Rho GTPase activating protein 25 isoform a [Homo
sapiens]
Length = 645
Score = 53.5 bits (127), Expect = 5e-07
Identities = 32/110 (29%), Positives = 50/110 (45%), Gaps = 8/110 (7%)
Query: 59 GWLHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRR 118
GWL KQ S ++ W++R+FVL L+YYKD + G + LP I+ +
Sbjct: 51 GWLKKQRSI-VKNWQQRYFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGK 109
Query: 119 FTF-------TAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQ 161
F F G +YVL A + ++ W++ L R + +GQ
Sbjct: 110 FVFEIIPASWDQNRMGQDSYVLMASSQAEMEEWVKFLRRVAGTPCGVFGQ 159
>gi|7661882 Rho GTPase activating protein 25 isoform b [Homo
sapiens]
Length = 638
Score = 53.5 bits (127), Expect = 5e-07
Identities = 32/110 (29%), Positives = 50/110 (45%), Gaps = 8/110 (7%)
Query: 59 GWLHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRR 118
GWL KQ S ++ W++R+FVL L+YYKD + G + LP I+ +
Sbjct: 44 GWLKKQRSI-VKNWQQRYFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGK 102
Query: 119 FTF-------TAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQ 161
F F G +YVL A + ++ W++ L R + +GQ
Sbjct: 103 FVFEIIPASWDQNRMGQDSYVLMASSQAEMEEWVKFLRRVAGTPCGVFGQ 152
>gi|41349484 proline-rich protein BstNI subfamily 1 isoform 2
preproprotein [Homo sapiens]
Length = 198
Score = 53.1 bits (126), Expect = 7e-07
Identities = 52/180 (28%), Positives = 70/180 (38%), Gaps = 39/180 (21%)
Query: 160 GQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLH 219
G P+ P+ PQ G P GP PP +G + P+ G+P+ P P D
Sbjct: 34 GNPQGPS-PQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPPPP---GKPQ--GPPPQGD-- 85
Query: 220 SGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTA----PPARPHTPLSR 275
++RSP PP P P+ + PP G+ PP +P P
Sbjct: 86 ------KSRSP------RSPPGKPQGPPPQGGKPQGPPPQGGNKPQGPPPPGKPQGP--- 130
Query: 276 IDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGG---GKPP---RSPQHWSQEPRTQP-GPP 328
P G + Q+ PP +GPP + G G PP +PQ P QP GPP
Sbjct: 131 -----PAQGGSKSQSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQPQGPP 185
Score = 51.6 bits (122), Expect = 2e-06
Identities = 45/161 (27%), Positives = 62/161 (38%), Gaps = 22/161 (13%)
Query: 160 GQPRSPA-----RPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSP 214
G+P+ P +PQ PG P GPP +G++ R SP G+P+ P P
Sbjct: 55 GKPQGPPPQGGNKPQGPPPPGKPQGPPP--QGDKSRSPRSPP--------GKPQ--GPPP 102
Query: 215 TTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLS 274
G + P P +P P + +S AR PP P P +
Sbjct: 103 QGGKPQGPPPQGGNKPQGPPPPGKPQGPPAQGGSKSQSARSPPGK-----PQGPPQQEGN 157
Query: 275 RIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQ 315
PP G +Q + P +GPP GG+P R PQ
Sbjct: 158 NPQGPPPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRPPQ 198
Score = 38.9 bits (89), Expect = 0.013
Identities = 32/113 (28%), Positives = 43/113 (38%), Gaps = 17/113 (15%)
Query: 472 PQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLG 531
PQ PPP +P P P QG++S S P + P+ + P GG+K P G
Sbjct: 68 PQGPPPPGKPQGPPP--QGDKSRSPRSPPGKPQGPPPQGGKPQGPPPQGGNKPQGPPPPG 125
Query: 532 -------LGSPRVSRASSPEGRHLPSPQLGTKSKEHHPLLADFRRSPGAGSQP 577
G + A SP G+ PQ + + P P AG P
Sbjct: 126 KPQGPPAQGGSKSQSARSPPGKPQGPPQQEGNNPQGPP--------PPAGGNP 170
Score = 37.0 bits (84), Expect = 0.050
Identities = 28/94 (29%), Positives = 38/94 (40%), Gaps = 10/94 (10%)
Query: 236 LSRPPSP-LSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRP 294
+S+ SP L P+ + P G PP +P P + +P GP P
Sbjct: 23 VSQEESPSLIAGNPQGPSPQGGNKPQGPPPPPGKPQGPPPQGGNKPQ---GPP------P 73
Query: 295 PTPRRGPPSEAGGGKPPRSPQHWSQEPRTQPGPP 328
P +GPP + + PRSP Q P Q G P
Sbjct: 74 PGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGKP 107
>gi|237757326 synaptojanin 1 isoform d [Homo sapiens]
Length = 1526
Score = 52.8 bits (125), Expect = 9e-07
Identities = 43/117 (36%), Positives = 58/117 (49%), Gaps = 13/117 (11%)
Query: 207 PRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLP-RPRSAPARRPPAPSGDTAP 265
P+ L PS ++ L + SP +S P P SLP RP AP+R P PS ++P
Sbjct: 1022 PQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVP-SLPIRPSRAPSRTPGPPSAQSSP 1080
Query: 266 -PARPHTPLSRIDVRPPLDWGPQRQTLSRP------PTPRRGPPSEAGGGKPPRSPQ 315
A+P TPL + D PL+ P+R RP P P + PP +G +P SPQ
Sbjct: 1081 IDAQPATPLPQKDPAQPLE--PKRPPPPRPVAPPTRPAPPQRPPPPSGRSQP--SPQ 1133
Score = 38.5 bits (88), Expect = 0.017
Identities = 54/195 (27%), Positives = 66/195 (33%), Gaps = 44/195 (22%)
Query: 157 DDYG---QPRSPARPQPGEGPG---GPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLL 210
DDY + P QP G P P S + ISE P V L R
Sbjct: 1011 DDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGP-VPSLPIRPSRAPSR 1069
Query: 211 TPSPTTDLHSGLQMRRAR---SPDLFTPLS--RPPSPLSLPRP-RSAPARRPPAPSG--- 261
TP P + S + + A D PL RPP P + P R AP +RPP PSG
Sbjct: 1070 TPGPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGRSQ 1129
Query: 262 -----DTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRR-----GPPSEAGGGKPP 311
A P GP + +RP P R P S A
Sbjct: 1130 PSPQAGLAGP------------------GPAGYSTARPTIPPRAGVISAPQSHARASAGR 1171
Query: 312 RSPQHWSQEPRTQPG 326
+P+ S+ T G
Sbjct: 1172 LTPESQSKTSETSKG 1186
>gi|237757310 synaptojanin 1 isoform a [Homo sapiens]
Length = 1612
Score = 51.6 bits (122), Expect = 2e-06
Identities = 45/136 (33%), Positives = 60/136 (44%), Gaps = 7/136 (5%)
Query: 207 PRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLP-RPRSAPARRPPAPSGDTAP 265
P+ L PS ++ L + SP +S P P SLP RP AP+R P PS ++P
Sbjct: 1066 PQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVP-SLPIRPSRAPSRTPGPPSAQSSP 1124
Query: 266 -PARPHTPLSRIDVRPPLDWGPQRQTLSRP--PTPRRGPPSEAGGGKPPRSPQHWSQEPR 322
A+P TPL + D PL+ P+R RP P R PP RSP +E
Sbjct: 1125 IDAQPATPLPQKDPAQPLE--PKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFG 1182
Query: 323 TQPGPPLESTFHQSLE 338
PP + +E
Sbjct: 1183 GIGAPPSPGVARREME 1198
>gi|237757308 synaptojanin 1 isoform b [Homo sapiens]
Length = 1350
Score = 51.6 bits (122), Expect = 2e-06
Identities = 45/136 (33%), Positives = 60/136 (44%), Gaps = 7/136 (5%)
Query: 207 PRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLP-RPRSAPARRPPAPSGDTAP 265
P+ L PS ++ L + SP +S P P SLP RP AP+R P PS ++P
Sbjct: 1066 PQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVP-SLPIRPSRAPSRTPGPPSAQSSP 1124
Query: 266 -PARPHTPLSRIDVRPPLDWGPQRQTLSRP--PTPRRGPPSEAGGGKPPRSPQHWSQEPR 322
A+P TPL + D PL+ P+R RP P R PP RSP +E
Sbjct: 1125 IDAQPATPLPQKDPAQPLE--PKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFG 1182
Query: 323 TQPGPPLESTFHQSLE 338
PP + +E
Sbjct: 1183 GIGAPPSPGVARREME 1198
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.133 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,702,602
Number of Sequences: 37866
Number of extensions: 2310502
Number of successful extensions: 23359
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 264
Number of HSP's successfully gapped in prelim test: 1706
Number of HSP's that attempted gapping in prelim test: 14213
Number of HSP's gapped (non-prelim): 7965
length of query: 583
length of database: 18,247,518
effective HSP length: 108
effective length of query: 475
effective length of database: 14,157,990
effective search space: 6725045250
effective search space used: 6725045250
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.