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Search of human proteins with 237512996
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|237512996 histamine H4 receptor isoform 3 [Homo sapiens]
(67 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|237512996 histamine H4 receptor isoform 3 [Homo sapiens] 129 4e-31
gi|14251205 histamine H4 receptor isoform 1 [Homo sapiens] 129 7e-31
gi|219842331 histamine H4 receptor isoform 2 [Homo sapiens] 124 2e-29
gi|194018562 histamine receptor H3 [Homo sapiens] 59 8e-10
gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens] 47 2e-06
gi|4503383 dopamine receptor D1 [Homo sapiens] 45 9e-06
gi|4501953 adenosine A3 receptor isoform 2 [Homo sapiens] 44 2e-05
gi|46559769 adenosine A3 receptor isoform 1 [Homo sapiens] 44 2e-05
gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo sap... 41 2e-04
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 41 2e-04
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] 41 2e-04
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] 41 2e-04
gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens] 41 2e-04
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] 41 2e-04
gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens] 41 2e-04
gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens] 41 2e-04
gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens] 41 2e-04
gi|4885121 chemokine (C-C motif) receptor 8 [Homo sapiens] 41 2e-04
gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens] 41 2e-04
gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo sa... 40 3e-04
gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo s... 40 3e-04
gi|15150803 opsin 4 isoform 1 [Homo sapiens] 40 5e-04
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 39 7e-04
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens] 38 0.002
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] 38 0.002
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] 38 0.002
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] 38 0.002
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 38 0.002
gi|4502641 chemokine (C-C motif) receptor 7 precursor [Homo sapi... 38 0.002
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] 38 0.002
>gi|237512996 histamine H4 receptor isoform 3 [Homo sapiens]
Length = 67
Score = 129 bits (325), Expect = 4e-31
Identities = 67/67 (100%), Positives = 67/67 (100%)
Query: 1 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
Sbjct: 1 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60
Query: 61 DFFVGVL 67
DFFVGVL
Sbjct: 61 DFFVGVL 67
>gi|14251205 histamine H4 receptor isoform 1 [Homo sapiens]
Length = 390
Score = 129 bits (323), Expect = 7e-31
Identities = 66/67 (98%), Positives = 67/67 (100%)
Query: 1 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
Sbjct: 1 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60
Query: 61 DFFVGVL 67
DFFVGV+
Sbjct: 61 DFFVGVI 67
>gi|219842331 histamine H4 receptor isoform 2 [Homo sapiens]
Length = 302
Score = 124 bits (311), Expect = 2e-29
Identities = 64/64 (100%), Positives = 64/64 (100%)
Query: 1 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
Sbjct: 1 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60
Query: 61 DFFV 64
DFFV
Sbjct: 61 DFFV 64
>gi|194018562 histamine receptor H3 [Homo sapiens]
Length = 445
Score = 58.9 bits (141), Expect = 8e-10
Identities = 30/55 (54%), Positives = 40/55 (72%)
Query: 11 SLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVG 65
S + LA M+L+ A +LGNALV+LAFV D +LR ++++F LNLAISDF VG
Sbjct: 30 SAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVG 84
>gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens]
Length = 590
Score = 47.4 bits (111), Expect = 2e-06
Identities = 21/52 (40%), Positives = 36/52 (69%)
Query: 16 VTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVL 67
V +AF ++A ++GN LVI++F V+K L+ ++YF L+LA +D +GV+
Sbjct: 69 VFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI 120
>gi|4503383 dopamine receptor D1 [Homo sapiens]
Length = 446
Score = 45.4 bits (106), Expect = 9e-06
Identities = 24/68 (35%), Positives = 40/68 (58%), Gaps = 1/68 (1%)
Query: 1 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHR-SSYFFLNLAI 59
M T + S R+ A F+SL+ + +LGN LV A + ++LR + +++F ++LA+
Sbjct: 9 MDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAV 68
Query: 60 SDFFVGVL 67
SD V VL
Sbjct: 69 SDLLVAVL 76
>gi|4501953 adenosine A3 receptor isoform 2 [Homo sapiens]
Length = 318
Score = 44.3 bits (103), Expect = 2e-05
Identities = 23/67 (34%), Positives = 43/67 (64%), Gaps = 3/67 (4%)
Query: 1 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60
MP+ ++ ++L+ T +T+ F+ L A ++GN LVI ++ +L+ + YF ++LA++
Sbjct: 1 MPNNSTALSLANVTYITMEIFIGLCA---IVGNVLVICVVKLNPSLQTTTFYFIVSLALA 57
Query: 61 DFFVGVL 67
D VGVL
Sbjct: 58 DIAVGVL 64
>gi|46559769 adenosine A3 receptor isoform 1 [Homo sapiens]
Length = 347
Score = 44.3 bits (103), Expect = 2e-05
Identities = 23/67 (34%), Positives = 43/67 (64%), Gaps = 3/67 (4%)
Query: 1 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 60
MP+ ++ ++L+ T +T+ F+ L A ++GN LVI ++ +L+ + YF ++LA++
Sbjct: 1 MPNNSTALSLANVTYITMEIFIGLCA---IVGNVLVICVVKLNPSLQTTTFYFIVSLALA 57
Query: 61 DFFVGVL 67
D VGVL
Sbjct: 58 DIAVGVL 64
>gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo
sapiens]
Length = 458
Score = 41.2 bits (95), Expect = 2e-04
Identities = 21/48 (43%), Positives = 33/48 (68%), Gaps = 2/48 (4%)
Query: 22 MSLVAFAIML--GNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVL 67
+S+V IM GN LVI+A ++K L + ++YF ++LAI+D VG+L
Sbjct: 58 LSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLL 105
>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
sapiens]
Length = 422
Score = 40.8 bits (94), Expect = 2e-04
Identities = 18/65 (27%), Positives = 40/65 (61%)
Query: 3 DTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDF 62
+T ++++S +V + + + F +LGNA V+ A ++++L++ ++Y +LA++D
Sbjct: 24 NTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDL 83
Query: 63 FVGVL 67
V VL
Sbjct: 84 MVSVL 88
>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
Length = 359
Score = 40.8 bits (94), Expect = 2e-04
Identities = 22/54 (40%), Positives = 34/54 (62%), Gaps = 1/54 (1%)
Query: 15 RVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRH-RSSYFFLNLAISDFFVGVL 67
+V L F+S V +LGN LV++A D+ LR +++YF ++LA +D V VL
Sbjct: 19 KVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVL 72
>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
Length = 428
Score = 40.8 bits (94), Expect = 2e-04
Identities = 22/54 (40%), Positives = 34/54 (62%), Gaps = 1/54 (1%)
Query: 15 RVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRH-RSSYFFLNLAISDFFVGVL 67
+V L F+S V +LGN LV++A D+ LR +++YF ++LA +D V VL
Sbjct: 19 KVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVL 72
>gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens]
Length = 402
Score = 40.8 bits (94), Expect = 2e-04
Identities = 22/54 (40%), Positives = 34/54 (62%), Gaps = 1/54 (1%)
Query: 15 RVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRH-RSSYFFLNLAISDFFVGVL 67
+V L F+S V +LGN LV++A D+ LR +++YF ++LA +D V VL
Sbjct: 19 KVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVL 72
>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
Length = 360
Score = 40.8 bits (94), Expect = 2e-04
Identities = 22/54 (40%), Positives = 34/54 (62%), Gaps = 1/54 (1%)
Query: 15 RVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRH-RSSYFFLNLAISDFFVGVL 67
+V L F+S V +LGN LV++A D+ LR +++YF ++LA +D V VL
Sbjct: 19 KVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVL 72
>gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]
Length = 387
Score = 40.8 bits (94), Expect = 2e-04
Identities = 22/54 (40%), Positives = 34/54 (62%), Gaps = 1/54 (1%)
Query: 15 RVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRH-RSSYFFLNLAISDFFVGVL 67
+V L F+S V +LGN LV++A D+ LR +++YF ++LA +D V VL
Sbjct: 19 KVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVL 72
>gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]
Length = 378
Score = 40.8 bits (94), Expect = 2e-04
Identities = 22/54 (40%), Positives = 34/54 (62%), Gaps = 1/54 (1%)
Query: 15 RVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRH-RSSYFFLNLAISDFFVGVL 67
+V L F+S V +LGN LV++A D+ LR +++YF ++LA +D V VL
Sbjct: 19 KVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVL 72
>gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]
Length = 388
Score = 40.8 bits (94), Expect = 2e-04
Identities = 22/54 (40%), Positives = 34/54 (62%), Gaps = 1/54 (1%)
Query: 15 RVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRH-RSSYFFLNLAISDFFVGVL 67
+V L F+S V +LGN LV++A D+ LR +++YF ++LA +D V VL
Sbjct: 19 KVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVL 72
>gi|4885121 chemokine (C-C motif) receptor 8 [Homo sapiens]
Length = 355
Score = 40.8 bits (94), Expect = 2e-04
Identities = 22/47 (46%), Positives = 30/47 (63%)
Query: 15 RVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISD 61
++ LA F L+ +LGN+LVIL VV K LR + + LNLA+SD
Sbjct: 35 KLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSD 81
>gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens]
Length = 532
Score = 40.8 bits (94), Expect = 2e-04
Identities = 16/51 (31%), Positives = 35/51 (68%)
Query: 16 VTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGV 66
+T+A ++V+ ++GN LV+++F V+ L+ ++Y+ L+LA +D +G+
Sbjct: 31 ITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGI 81
>gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo
sapiens]
Length = 471
Score = 40.4 bits (93), Expect = 3e-04
Identities = 20/58 (34%), Positives = 35/58 (60%)
Query: 10 LSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVL 67
L L + A ++V + GN LVI+A ++K L++ ++YF ++LAI+D +G L
Sbjct: 69 LHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFL 126
>gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo
sapiens]
Length = 481
Score = 40.4 bits (93), Expect = 3e-04
Identities = 18/48 (37%), Positives = 32/48 (66%)
Query: 19 AFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGV 66
A + +V + GN LVILA ++K L++ ++YF ++LA++D VG+
Sbjct: 58 ALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGL 105
>gi|15150803 opsin 4 isoform 1 [Homo sapiens]
Length = 478
Score = 39.7 bits (91), Expect = 5e-04
Identities = 21/58 (36%), Positives = 32/58 (55%)
Query: 7 TINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFV 64
T+++ TL + LV MLGN VI F ++LR ++ F +NLA+SDF +
Sbjct: 62 TVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCRSRSLRTPANMFIINLAVSDFLM 119
>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
sapiens]
Length = 366
Score = 39.3 bits (90), Expect = 7e-04
Identities = 18/56 (32%), Positives = 34/56 (60%)
Query: 12 LSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVL 67
+ +++ ++ +S +A N+LVI A +V + L H ++Y +LA++DF V VL
Sbjct: 20 MPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVL 75
>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
Length = 413
Score = 38.1 bits (87), Expect = 0.002
Identities = 19/51 (37%), Positives = 30/51 (58%)
Query: 16 VTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGV 66
V + MSL+ AI+ GN LVI A + L+ ++YF +LA +D +G+
Sbjct: 34 VGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGL 84
>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
Length = 432
Score = 38.1 bits (87), Expect = 0.002
Identities = 18/59 (30%), Positives = 32/59 (54%)
Query: 8 INLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGV 66
IN +V + ++L+ + GN LV+++ K LR S+Y ++LA++D V V
Sbjct: 74 INYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAV 132
>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
Length = 479
Score = 38.1 bits (87), Expect = 0.002
Identities = 18/59 (30%), Positives = 32/59 (54%)
Query: 8 INLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGV 66
IN +V + ++L+ + GN LV+++ K LR S+Y ++LA++D V V
Sbjct: 74 INYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAV 132
>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
Length = 445
Score = 38.1 bits (87), Expect = 0.002
Identities = 18/59 (30%), Positives = 32/59 (54%)
Query: 8 INLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGV 66
IN +V + ++L+ + GN LV+++ K LR S+Y ++LA++D V V
Sbjct: 74 INYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAV 132
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 38.1 bits (87), Expect = 0.002
Identities = 18/62 (29%), Positives = 38/62 (61%), Gaps = 1/62 (1%)
Query: 4 TNSTI-NLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDF 62
+NST+ L ++ +++ + ++GN LVIL+ +++LR ++YF +NLA++D
Sbjct: 33 SNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADL 92
Query: 63 FV 64
+
Sbjct: 93 LL 94
>gi|4502641 chemokine (C-C motif) receptor 7 precursor [Homo
sapiens]
Length = 378
Score = 37.7 bits (86), Expect = 0.002
Identities = 16/44 (36%), Positives = 27/44 (61%)
Query: 18 LAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISD 61
L S++ F +LGN LV+L ++ K L+ + + LNLA++D
Sbjct: 61 LPIMYSIICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVAD 104
>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
Length = 397
Score = 37.7 bits (86), Expect = 0.002
Identities = 16/57 (28%), Positives = 37/57 (64%)
Query: 11 SLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVL 67
S + ++T+ ++++ + GN +V LA +++ LR+ ++ F ++LAI+D +G+L
Sbjct: 14 STACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLL 70
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.334 0.142 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 1,581,917
Number of Sequences: 37866
Number of extensions: 34694
Number of successful extensions: 664
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 238
Number of HSP's successfully gapped in prelim test: 80
Number of HSP's that attempted gapping in prelim test: 398
Number of HSP's gapped (non-prelim): 327
length of query: 67
length of database: 18,247,518
effective HSP length: 40
effective length of query: 27
effective length of database: 16,732,878
effective search space: 451787706
effective search space used: 451787706
T: 11
A: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 39 (21.6 bits)
S2: 55 (25.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.