Search of human proteins with 236462773

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens]
         (590 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens]          1189   0.0  
gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens]          1179   0.0  
gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens]          1171   0.0  
gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens]           1147   0.0  
gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens]           1123   0.0  
gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens]             1090   0.0  
gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens]               695   0.0  
gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens]           694   0.0  
gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens]                  662   0.0  
gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens]               489   e-138
gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]                      395   e-110
gi|7669530 neuregulin 2 isoform 3 [Homo sapiens]                      381   e-105
gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]                      377   e-104
gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]                      368   e-101
gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens]           333   2e-91
gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens]                 333   2e-91
gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens]            315   7e-86
gi|236464356 neuregulin 1 isoform HRG-gamma3 [Homo sapiens]           290   2e-78
gi|236462984 neuregulin 1 isoform HRG-gamma2 [Homo sapiens]           280   3e-75
gi|116006965 neuregulin 1 isoform HRG-gamma [Homo sapiens]            272   7e-73
gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens]                   139   7e-33
gi|66730481 neuregulin 3 [Homo sapiens]                               111   2e-24
gi|115298665 neurotrimin isoform 2 [Homo sapiens]                      57   6e-08
gi|7705413 neurotrimin isoform 1 [Homo sapiens]                        57   6e-08
gi|110349719 titin isoform N2-A [Homo sapiens]                         55   1e-07
gi|221316757 neurotrimin isoform 3 [Homo sapiens]                      54   5e-07
gi|45594240 limbic system-associated membrane protein [Homo sapi...    52   2e-06
gi|221316762 neurotrimin isoform 4 [Homo sapiens]                      51   3e-06
gi|110349717 titin isoform novex-2 [Homo sapiens]                      50   8e-06
gi|110349713 titin isoform novex-1 [Homo sapiens]                      50   8e-06

>gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens]
          Length = 590

 Score = 1189 bits (3077), Expect = 0.0
 Identities = 590/590 (100%), Positives = 590/590 (100%)

Query: 1   MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
           MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN
Sbjct: 1   MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60

Query: 61  KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTG 120
           KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTG
Sbjct: 61  KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTG 120

Query: 121 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGI 180
           TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGI
Sbjct: 121 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGI 180

Query: 181 EFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMM 240
           EFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMM
Sbjct: 181 EFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMM 240

Query: 241 NIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT 300
           NIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT
Sbjct: 241 NIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT 300

Query: 301 PSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARE 360
           PSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARE
Sbjct: 301 PSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARE 360

Query: 361 TPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSP 420
           TPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSP
Sbjct: 361 TPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSP 420

Query: 421 FMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQE 480
           FMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQE
Sbjct: 421 FMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQE 480

Query: 481 YEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLG 540
           YEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLG
Sbjct: 481 YEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLG 540

Query: 541 IQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV 590
           IQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV
Sbjct: 541 IQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV 590


>gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens]
          Length = 607

 Score = 1179 bits (3049), Expect = 0.0
 Identities = 590/607 (97%), Positives = 590/607 (97%), Gaps = 17/607 (2%)

Query: 1   MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
           MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN
Sbjct: 1   MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60

Query: 61  KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------- 112
           KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN        
Sbjct: 61  KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 120

Query: 113 ---------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTG 163
                    ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTG
Sbjct: 121 STEGAYVSSATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTG 180

Query: 164 DRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKK 223
           DRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKK
Sbjct: 181 DRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKK 240

Query: 224 LHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFS 283
           LHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFS
Sbjct: 241 LHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFS 300

Query: 284 TSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLN 343
           TSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLN
Sbjct: 301 TSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLN 360

Query: 344 GTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMS 403
           GTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMS
Sbjct: 361 GTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMS 420

Query: 404 PPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLP 463
           PPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLP
Sbjct: 421 PPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLP 480

Query: 464 ASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNS 523
           ASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNS
Sbjct: 481 ASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNS 540

Query: 524 ESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIA 583
           ESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIA
Sbjct: 541 ESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIA 600

Query: 584 NQDPIAV 590
           NQDPIAV
Sbjct: 601 NQDPIAV 607


>gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens]
          Length = 624

 Score = 1171 bits (3029), Expect = 0.0
 Identities = 589/624 (94%), Positives = 590/624 (94%), Gaps = 34/624 (5%)

Query: 1   MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
           MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN
Sbjct: 1   MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60

Query: 61  KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------- 112
           KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN        
Sbjct: 61  KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 120

Query: 113 --------------------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 146
                                     +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD
Sbjct: 121 STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 180

Query: 147 LSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVV 206
           LSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVV
Sbjct: 181 LSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVV 240

Query: 207 GIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKN 266
           GIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKN
Sbjct: 241 GIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKN 300

Query: 267 VISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSV 326
           VISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSV
Sbjct: 301 VISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSV 360

Query: 327 ENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSP 386
           ENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSP
Sbjct: 361 ENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSP 420

Query: 387 VDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQ 446
           VDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQ
Sbjct: 421 VDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQ 480

Query: 447 QFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHI 506
           QFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHI
Sbjct: 481 QFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHI 540

Query: 507 ANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAG 566
           ANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAG
Sbjct: 541 ANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAG 600

Query: 567 RFSTQEEIQARLSSVIANQDPIAV 590
           RFSTQEEIQARLSSVIANQDPIAV
Sbjct: 601 RFSTQEEIQARLSSVIANQDPIAV 624


>gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens]
          Length = 645

 Score = 1147 bits (2967), Expect = 0.0
 Identities = 577/612 (94%), Positives = 578/612 (94%), Gaps = 34/612 (5%)

Query: 13  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
           ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93

Query: 73  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------------------- 112
           KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN                    
Sbjct: 94  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153

Query: 113 --------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 158
                         +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP
Sbjct: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 213

Query: 159 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 218
           NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK
Sbjct: 214 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 273

Query: 219 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 278
           KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA
Sbjct: 274 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 333

Query: 279 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 338
           ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP
Sbjct: 334 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 393

Query: 339 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP 398
           RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP
Sbjct: 394 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP 453

Query: 399 PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD 458
           PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD
Sbjct: 454 PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD 513

Query: 459 SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS 518
           SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS
Sbjct: 514 SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS 573

Query: 519 QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL 578
           QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL
Sbjct: 574 QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL 633

Query: 579 SSVIANQDPIAV 590
           SSVIANQDPIAV
Sbjct: 634 SSVIANQDPIAV 645


>gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens]
          Length = 637

 Score = 1123 bits (2905), Expect = 0.0
 Identities = 569/612 (92%), Positives = 570/612 (93%), Gaps = 42/612 (6%)

Query: 13  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
           ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93

Query: 73  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------------------- 112
           KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN                    
Sbjct: 94  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153

Query: 113 --------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 158
                         +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP
Sbjct: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 213

Query: 159 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 218
           NEFTGDRCQNYVMASFYK        AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK
Sbjct: 214 NEFTGDRCQNYVMASFYK--------AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 265

Query: 219 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 278
           KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA
Sbjct: 266 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 325

Query: 279 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 338
           ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP
Sbjct: 326 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 385

Query: 339 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP 398
           RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP
Sbjct: 386 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP 445

Query: 399 PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD 458
           PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD
Sbjct: 446 PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD 505

Query: 459 SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS 518
           SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS
Sbjct: 506 SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS 565

Query: 519 QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL 578
           QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL
Sbjct: 566 QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL 625

Query: 579 SSVIANQDPIAV 590
           SSVIANQDPIAV
Sbjct: 626 SSVIANQDPIAV 637


>gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens]
          Length = 640

 Score = 1090 bits (2819), Expect = 0.0
 Identities = 556/612 (90%), Positives = 558/612 (91%), Gaps = 39/612 (6%)

Query: 13  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
           ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93

Query: 73  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------------------- 112
           KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN                    
Sbjct: 94  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153

Query: 113 --------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 158
                         +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC 
Sbjct: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQ 213

Query: 159 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 218
             FTG RC   V             +AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK
Sbjct: 214 PGFTGARCTENVPMKVQNQ-----EKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 268

Query: 219 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 278
           KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA
Sbjct: 269 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 328

Query: 279 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 338
           ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP
Sbjct: 329 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 388

Query: 339 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP 398
           RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP
Sbjct: 389 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP 448

Query: 399 PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD 458
           PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD
Sbjct: 449 PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD 508

Query: 459 SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS 518
           SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS
Sbjct: 509 SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS 568

Query: 519 QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL 578
           QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL
Sbjct: 569 QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL 628

Query: 579 SSVIANQDPIAV 590
           SSVIANQDPIAV
Sbjct: 629 SSVIANQDPIAV 640


>gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens]
          Length = 459

 Score =  695 bits (1793), Expect = 0.0
 Identities = 352/396 (88%), Positives = 354/396 (89%), Gaps = 42/396 (10%)

Query: 13  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
           ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93

Query: 73  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------------------- 112
           KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN                    
Sbjct: 94  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153

Query: 113 --------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 158
                         +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP
Sbjct: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 213

Query: 159 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 218
           NEFTGDRCQNYVMASFYK        AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK
Sbjct: 214 NEFTGDRCQNYVMASFYK--------AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 265

Query: 219 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 278
           KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA
Sbjct: 266 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 325

Query: 279 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 338
           ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP
Sbjct: 326 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 385

Query: 339 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERY 374
           RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSER+
Sbjct: 386 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERH 421


>gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens]
          Length = 420

 Score =  694 bits (1791), Expect = 0.0
 Identities = 352/395 (89%), Positives = 353/395 (89%), Gaps = 42/395 (10%)

Query: 13  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
           ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93

Query: 73  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------------------- 112
           KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN                    
Sbjct: 94  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153

Query: 113 --------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 158
                         +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP
Sbjct: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 213

Query: 159 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 218
           NEFTGDRCQNYVMASFYK        AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK
Sbjct: 214 NEFTGDRCQNYVMASFYK--------AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 265

Query: 219 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 278
           KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA
Sbjct: 266 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 325

Query: 279 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 338
           ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP
Sbjct: 326 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 385

Query: 339 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSER 373
           RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSER
Sbjct: 386 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSER 420


>gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens]
          Length = 462

 Score =  662 bits (1707), Expect = 0.0
 Identities = 339/396 (85%), Positives = 342/396 (86%), Gaps = 39/396 (9%)

Query: 13  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
           ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93

Query: 73  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------------------- 112
           KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN                    
Sbjct: 94  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153

Query: 113 --------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 158
                         +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC 
Sbjct: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQ 213

Query: 159 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 218
             FTG RC   V             +AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK
Sbjct: 214 PGFTGARCTENVPMKVQNQ-----EKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 268

Query: 219 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 278
           KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA
Sbjct: 269 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 328

Query: 279 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 338
           ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP
Sbjct: 329 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 388

Query: 339 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERY 374
           RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSER+
Sbjct: 389 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERH 424


>gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens]
          Length = 308

 Score =  489 bits (1258), Expect = e-138
 Identities = 242/270 (89%), Positives = 247/270 (91%), Gaps = 5/270 (1%)

Query: 105 NITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGD 164
           +I+I +  ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC   FTG 
Sbjct: 6   HISIEDITATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGA 65

Query: 165 RCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKL 224
           RC   V             +AEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKL
Sbjct: 66  RCTENVPMKVQNQ-----EKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKL 120

Query: 225 HDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFST 284
           HDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFST
Sbjct: 121 HDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFST 180

Query: 285 SHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNG 344
           SHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNG
Sbjct: 181 SHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNG 240

Query: 345 TGGPRECNSFLRHARETPDSYRDSPHSERY 374
           TGGPRECNSFLRHARETPDSYRDSPHSER+
Sbjct: 241 TGGPRECNSFLRHARETPDSYRDSPHSERH 270


>gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]
          Length = 852

 Score =  395 bits (1014), Expect = e-110
 Identities = 248/613 (40%), Positives = 350/613 (57%), Gaps = 65/613 (10%)

Query: 3   KGRAGRVGTT--ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
           K   G++  T  A  P+LK+MKSQ    G K  L+CE ++      ++WFK+G ELNR  
Sbjct: 222 KKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRS- 280

Query: 61  KPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST 118
             ++I+I+   G+  S L+ NK  + D+GEY+C+  + LG D+    + +   + T +S 
Sbjct: 281 --RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSW 338

Query: 119 TGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHL 178
           +G  H  KC E  K++CVNGG C+ ++ ++  S   CKCP  +TGDRCQ + M +F KHL
Sbjct: 339 SG--HARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVNFSKHL 393

Query: 179 GIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNN 238
           G E  EAEELYQKRVLTITGIC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++     N
Sbjct: 394 GFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN 453

Query: 239 MMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVT 298
             ++ANGP HP   PE +Q+ + Y+SKNV +++H++ RE ET+FS SH  S +HH +T T
Sbjct: 454 -RSLANGPSHPRLDPEEIQMAD-YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTAT 511

Query: 299 QT-----PSHSWSNGHTESILSESHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPR 349
            T      SH+WS   +ES+ S+S S I++SSV  S+ +SP        R         R
Sbjct: 512 PTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERR 571

Query: 350 ECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSM 409
              +   H  ++ DS RDSPHSERYVSA+TTPAR+SPVDFH   + + P  E++ P S+ 
Sbjct: 572 RATAPPYH--DSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAH 629

Query: 410 TVSMPSMA-VSPFMEEERPLLLVTPPRLREKKFDHHP-------QQFSSFHHNPAHDS-- 459
            VS+P  A +S  + E++PLL    P          P       + + S+++  A     
Sbjct: 630 AVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPR 689

Query: 460 ----------NSLPASPLRIVEDEEYETTQEYEPAQEPVKKL--------ANSRRAKRTK 501
                      SLPASP RI ED+EYETTQE  P   P  +         A  RR +R++
Sbjct: 690 RGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSR 749

Query: 502 PNGHIANR-------LEVDSNTSSQSSNSESETEDERVG----EDTPFLGIQNPL-AASL 549
            NG  A R       L + S +   S+++  +  D+  G    E TPFLG++    A   
Sbjct: 750 LNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRS 809

Query: 550 EATPAFRLADSRT 562
           ++ P    ADSRT
Sbjct: 810 DSPPLCPAADSRT 822


>gi|7669530 neuregulin 2 isoform 3 [Homo sapiens]
          Length = 858

 Score =  381 bits (978), Expect = e-105
 Identities = 246/619 (39%), Positives = 346/619 (55%), Gaps = 71/619 (11%)

Query: 3   KGRAGRVGTT--ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
           K   G++  T  A  P+LK+MKSQ    G K  L+CE ++      ++WFK+G ELNR  
Sbjct: 222 KKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRS- 280

Query: 61  KPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST 118
             ++I+I+   G+  S L+ NK  + D+GEY+C+  + LG D+    + +   + T +S 
Sbjct: 281 --RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSW 338

Query: 119 TGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY--- 175
           +G  H  KC E  K++CVNGG C+ ++ ++  S   CKCPN F G RC   +    Y   
Sbjct: 339 SG--HARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPNGFFGQRCLEKLPLRLYMPD 393

Query: 176 ---KHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSL 232
              KHLG E  EAEELYQKRVLTITGIC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++
Sbjct: 394 PKQKHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNM 453

Query: 233 RSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAH 292
                N  ++ANGP HP   PE +Q+ + Y+SKNV +++H++ RE ET+FS SH  S +H
Sbjct: 454 CPAHQN-RSLANGPSHPRLDPEEIQMAD-YISKNVPATDHVIRRETETTFSGSHSCSPSH 511

Query: 293 HSTTVTQT-----PSHSWSNGHTESILSESHSVIVMSSVENSRHSSP----TGGPRGRLN 343
           H +T T T      SH+WS   +ES+ S+S S I++SSV  S+ +SP        R    
Sbjct: 512 HCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAY 571

Query: 344 GTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMS 403
                R   +   H  ++ DS RDSPHSERYVSA+TTPAR+SPVDFH   + + P  E++
Sbjct: 572 NLEERRRATAPPYH--DSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEIT 629

Query: 404 PPVSSMTVSMPSMA-VSPFMEEERPLLLVTPPRLREKKFDHHP-------QQFSSFHHNP 455
            P S+  VS+P  A +S  + E++PLL    P          P       + + S+++  
Sbjct: 630 SPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPA 689

Query: 456 AHDS------------NSLPASPLRIVEDEEYETTQEYEPAQEPVKKL--------ANSR 495
           A                SLPASP RI ED+EYETTQE  P   P  +         A  R
Sbjct: 690 AGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPR 749

Query: 496 RAKRTKPNGHIANR-------LEVDSNTSSQSSNSESETEDERVG----EDTPFLGIQNP 544
           R +R++ NG  A R       L + S +   S+++  +  D+  G    E TPFLG++  
Sbjct: 750 RWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGA 809

Query: 545 L-AASLEATPAFRLADSRT 562
             A   ++ P    ADSRT
Sbjct: 810 HDALRSDSPPLCPAADSRT 828


>gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]
          Length = 844

 Score =  377 bits (968), Expect = e-104
 Identities = 243/613 (39%), Positives = 345/613 (56%), Gaps = 73/613 (11%)

Query: 3   KGRAGRVGTT--ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
           K   G++  T  A  P+LK+MKSQ    G K  L+CE ++      ++WFK+G ELNR  
Sbjct: 222 KKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRS- 280

Query: 61  KPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST 118
             ++I+I+   G+  S L+ NK  + D+GEY+C+  + LG D+    + +   + T +S 
Sbjct: 281 --RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSW 338

Query: 119 TGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHL 178
           +G  H  KC E  K++CVNGG C+ ++ ++  S   CKCP  +TGDRCQ + M +F K  
Sbjct: 339 SG--HARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVNFSK-- 391

Query: 179 GIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNN 238
                 AEELYQKRVLTITGIC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++     N
Sbjct: 392 ------AEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN 445

Query: 239 MMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVT 298
             ++ANGP HP   PE +Q+ + Y+SKNV +++H++ RE ET+FS SH  S +HH +T T
Sbjct: 446 -RSLANGPSHPRLDPEEIQMAD-YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTAT 503

Query: 299 QT-----PSHSWSNGHTESILSESHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPR 349
            T      SH+WS   +ES+ S+S S I++SSV  S+ +SP        R         R
Sbjct: 504 PTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERR 563

Query: 350 ECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSM 409
              +   H  ++ DS RDSPHSERYVSA+TTPAR+SPVDFH   + + P  E++ P S+ 
Sbjct: 564 RATAPPYH--DSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAH 621

Query: 410 TVSMPSMA-VSPFMEEERPLLLVTPPRLREKKFDHHP-------QQFSSFHHNPAHDS-- 459
            VS+P  A +S  + E++PLL    P          P       + + S+++  A     
Sbjct: 622 AVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPR 681

Query: 460 ----------NSLPASPLRIVEDEEYETTQEYEPAQEPVKKL--------ANSRRAKRTK 501
                      SLPASP RI ED+EYETTQE  P   P  +         A  RR +R++
Sbjct: 682 RGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSR 741

Query: 502 PNGHIANR-------LEVDSNTSSQSSNSESETEDERVG----EDTPFLGIQNPL-AASL 549
            NG  A R       L + S +   S+++  +  D+  G    E TPFLG++    A   
Sbjct: 742 LNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRS 801

Query: 550 EATPAFRLADSRT 562
           ++ P    ADSRT
Sbjct: 802 DSPPLCPAADSRT 814


>gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]
          Length = 850

 Score =  368 bits (944), Expect = e-101
 Identities = 240/613 (39%), Positives = 342/613 (55%), Gaps = 67/613 (10%)

Query: 3   KGRAGRVGTT--ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
           K   G++  T  A  P+LK+MKSQ    G K  L+CE ++      ++WFK+G ELNR  
Sbjct: 222 KKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRS- 280

Query: 61  KPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST 118
             ++I+I+   G+  S L+ NK  + D+GEY+C+  + LG D+    + +   + T +S 
Sbjct: 281 --RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSW 338

Query: 119 TGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHL 178
           +G  H  KC E  K++CVNGG C+ ++ ++  S   CKCPN F G RC   +    Y  +
Sbjct: 339 SG--HARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPNGFFGQRCLEKLPLRLY--M 391

Query: 179 GIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNN 238
                +AEELYQKRVLTITGIC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++     N
Sbjct: 392 PDPKQKAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN 451

Query: 239 MMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVT 298
             ++ANGP HP   PE +Q+ + Y+SKNV +++H++ RE ET+FS SH  S +HH +T T
Sbjct: 452 -RSLANGPSHPRLDPEEIQMAD-YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTAT 509

Query: 299 QT-----PSHSWSNGHTESILSESHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPR 349
            T      SH+WS   +ES+ S+S S I++SSV  S+ +SP        R         R
Sbjct: 510 PTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERR 569

Query: 350 ECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSM 409
              +   H  ++ DS RDSPHSERYVSA+TTPAR+SPVDFH   + + P  E++ P S+ 
Sbjct: 570 RATAPPYH--DSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAH 627

Query: 410 TVSMPSMA-VSPFMEEERPLLLVTPPRLREKKFDHHP-------QQFSSFHHNPAHDS-- 459
            VS+P  A +S  + E++PLL    P          P       + + S+++  A     
Sbjct: 628 AVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPR 687

Query: 460 ----------NSLPASPLRIVEDEEYETTQEYEPAQEPVKKL--------ANSRRAKRTK 501
                      SLPASP RI ED+EYETTQE  P   P  +         A  RR +R++
Sbjct: 688 RGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSR 747

Query: 502 PNGHIANR-------LEVDSNTSSQSSNSESETEDERVG----EDTPFLGIQNPL-AASL 549
            NG  A R       L + S +   S+++  +  D+  G    E TPFLG++    A   
Sbjct: 748 LNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRS 807

Query: 550 EATPAFRLADSRT 562
           ++ P    ADSRT
Sbjct: 808 DSPPLCPAADSRT 820


>gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens]
          Length = 207

 Score =  333 bits (855), Expect = 2e-91
 Identities = 163/163 (100%), Positives = 163/163 (100%)

Query: 13  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
           ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93

Query: 73  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEK 132
           KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEK
Sbjct: 94  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEK 153

Query: 133 TFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY 175
           TFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY
Sbjct: 154 TFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY 196


>gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens]
          Length = 422

 Score =  333 bits (855), Expect = 2e-91
 Identities = 163/163 (100%), Positives = 163/163 (100%)

Query: 13  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
           ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 249 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 308

Query: 73  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEK 132
           KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEK
Sbjct: 309 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEK 368

Query: 133 TFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY 175
           TFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY
Sbjct: 369 TFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY 411


>gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens]
          Length = 241

 Score =  315 bits (807), Expect = 7e-86
 Identities = 162/197 (82%), Positives = 163/197 (82%), Gaps = 34/197 (17%)

Query: 13  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
           ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93

Query: 73  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------------------- 112
           KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN                    
Sbjct: 94  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153

Query: 113 --------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 158
                         +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP
Sbjct: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 213

Query: 159 NEFTGDRCQNYVMASFY 175
           NEFTGDRCQNYVMASFY
Sbjct: 214 NEFTGDRCQNYVMASFY 230


>gi|236464356 neuregulin 1 isoform HRG-gamma3 [Homo sapiens]
          Length = 177

 Score =  290 bits (743), Expect = 2e-78
 Identities = 144/144 (100%), Positives = 144/144 (100%)

Query: 13  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
           ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93

Query: 73  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEK 132
           KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEK
Sbjct: 94  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEK 153

Query: 133 TFCVNGGECFMVKDLSNPSRYLCK 156
           TFCVNGGECFMVKDLSNPSRYLCK
Sbjct: 154 TFCVNGGECFMVKDLSNPSRYLCK 177


>gi|236462984 neuregulin 1 isoform HRG-gamma2 [Homo sapiens]
          Length = 194

 Score =  280 bits (715), Expect = 3e-75
 Identities = 144/161 (89%), Positives = 144/161 (89%), Gaps = 17/161 (10%)

Query: 13  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
           ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93

Query: 73  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-----------------ATS 115
           KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN                 ATS
Sbjct: 94  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSATS 153

Query: 116 TSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 156
           TSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK
Sbjct: 154 TSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 194


>gi|116006965 neuregulin 1 isoform HRG-gamma [Homo sapiens]
          Length = 211

 Score =  272 bits (695), Expect = 7e-73
 Identities = 143/178 (80%), Positives = 144/178 (80%), Gaps = 34/178 (19%)

Query: 13  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
           ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93

Query: 73  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------------------- 112
           KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN                    
Sbjct: 94  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153

Query: 113 --------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 156
                         +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK
Sbjct: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 211


>gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens]
          Length = 296

 Score =  139 bits (350), Expect = 7e-33
 Identities = 63/75 (84%), Positives = 66/75 (88%)

Query: 101 SASANITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNE 160
           +   N+      +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNE
Sbjct: 211 TTETNLQTAPKLSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNE 270

Query: 161 FTGDRCQNYVMASFY 175
           FTGDRCQNYVMASFY
Sbjct: 271 FTGDRCQNYVMASFY 285


>gi|66730481 neuregulin 3 [Homo sapiens]
          Length = 696

 Score =  111 bits (277), Expect = 2e-24
 Identities = 103/421 (24%), Positives = 188/421 (44%), Gaps = 41/421 (9%)

Query: 95  SKLGNDSASANITIVESNA------TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLS 148
           S   + S+SA  T  E++       T+ ST  + H   C +K+  +C+N GECF+++ L+
Sbjct: 252 SSSSSSSSSATTTTPETSTSPKFHTTTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLT 311

Query: 149 NPSRYLCKCPNEFTGDRCQNY------VMASFYKHLGIEFMEAEELYQKRVLTITGICIA 202
              ++ C+C   + G RC  +      +++    HLGIEFME+EE+YQ++VL+I+ I   
Sbjct: 312 GSHKH-CRCKEGYQGVRCDQFLPKTDSILSDPTDHLGIEFMESEEVYQRQVLSISCIIFG 370

Query: 203 LLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVN-Q 261
           +++VG+ C   Y K+KKQ K++ ++L+     +  ++   +      N    +VQL N  
Sbjct: 371 IVIVGMFCAAFYFKSKKQAKQIQEQLKVPQNGKSYSLKASSTMAKSENLVKSHVQLQNYS 430

Query: 262 YVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSH-SWSNGHTESILSESHSV 320
            V ++ +++   +E+  E+SF           S     +P   S S  H  S+ S     
Sbjct: 431 KVERHPVTA---LEKMMESSF-------VGPQSFPEVPSPDRGSQSVKHHRSLSSCCSPG 480

Query: 321 IVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTT 380
                +  +        PR RL G  GP       +   E+    +D+   + Y S+   
Sbjct: 481 QRSGMLHRNAFRRTPPSPRSRLGGIVGPA-----YQQLEESRIPDQDTIPCQGYSSSGLK 535

Query: 381 PARMSPVDFHTPSSPKSP---PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLR 437
             R + ++   PS   +P     E    V   +    S+ + P +  E   L +  P + 
Sbjct: 536 TQRNTSINMQLPSRETNPYFNSLEQKDLVGYSSTRASSVPIIPSVGLEETCLQM--PGIS 593

Query: 438 EKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRA 497
           E K      ++    ++    + S+P S   I E +E +     E  QE ++ L ++RR+
Sbjct: 594 EVK----SIKWCKNSYSADVVNVSIPVSDCLIAEQQEVKIL--LETVQEQIRILTDARRS 647

Query: 498 K 498
           +
Sbjct: 648 E 648


>gi|115298665 neurotrimin isoform 2 [Homo sapiens]
          Length = 344

 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 38/117 (32%), Positives = 54/117 (46%), Gaps = 5/117 (4%)

Query: 11  TTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 70
           T   PP + E K      G K  L+CE S+   S  F+W+K+   L    K   +K++ +
Sbjct: 218 TVNYPPYISEAKGTGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK--GVKVENR 274

Query: 71  PGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKC 127
           P  S+L     S  D G Y C   +KLG+ +AS  I +    A S  + GTS    C
Sbjct: 275 PFLSKLIFFNVSEHDYGNYTCVASNKLGHTNAS--IMLFGPGAVSEVSNGTSRRAGC 329


>gi|7705413 neurotrimin isoform 1 [Homo sapiens]
          Length = 344

 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 38/117 (32%), Positives = 54/117 (46%), Gaps = 5/117 (4%)

Query: 11  TTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 70
           T   PP + E K      G K  L+CE S+   S  F+W+K+   L    K   +K++ +
Sbjct: 218 TVNYPPYISEAKGTGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK--GVKVENR 274

Query: 71  PGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKC 127
           P  S+L     S  D G Y C   +KLG+ +AS  I +    A S  + GTS    C
Sbjct: 275 PFLSKLIFFNVSEHDYGNYTCVASNKLGHTNAS--IMLFGPGAVSEVSNGTSRRAGC 329


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 54/212 (25%), Positives = 86/212 (40%), Gaps = 35/212 (16%)

Query: 13   ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
            A P   ++++  E A G      CE  S   ++RF+WFK G E+   +K     I+    
Sbjct: 3454 AAPVIKRKIEPLEVALGHLAKFTCEIQSA-PNVRFQWFKAGREIYESDK---CSIRSSKY 3509

Query: 73   KSELRINKASLADSGEYMCKVISKLGNDSASANITIVE-------SNATSTST------- 118
             S L I +  + D GEY CK  ++ G+ S +A +T+ E       S   S +T       
Sbjct: 3510 ISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAK 3569

Query: 119  -----TGTSHLVKCAEKE-------KTFCVNGGECFMVKDLSN-----PSRYLCKCPNEF 161
                 TGT  +    +K+         + ++  E   + +LSN        Y CK  N+F
Sbjct: 3570 FICTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKF 3629

Query: 162  TGDRCQNYVMASFYKHLGIEFMEAEELYQKRV 193
              D CQ  ++     H   E    +    K+V
Sbjct: 3630 GADICQAELIIIDKPHFIKELEPVQSAINKKV 3661



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 44/196 (22%), Positives = 78/196 (39%), Gaps = 34/196 (17%)

Query: 8    RVGTTALPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIK 66
            RV    +PP   K++   +   GS + + C+ S     +  +WFK+G E++   K + + 
Sbjct: 5229 RVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLP-ISAQWFKDGKEISTSAKYRLVC 5287

Query: 67   IQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE----------SNATST 116
             ++      L +N   L D+  Y CKV +  G+D+ S  +T+ E            A   
Sbjct: 5288 HERSVS---LEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVKPGRQQAIPD 5344

Query: 117  STTGTSHLVKCAE-------KEKTFCVNGGECFM------------VKDLSNPSRYLCKC 157
            ST     ++K          K+    V+G +CF+              D S   +Y C  
Sbjct: 5345 STVEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHV 5404

Query: 158  PNEFTGDRCQNYVMAS 173
             N+   D C   ++ +
Sbjct: 5405 TNDVGSDSCTTMLLVT 5420



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 28/104 (26%), Positives = 47/104 (45%), Gaps = 5/104 (4%)

Query: 8    RVGTTALPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIK 66
            +V    +PP   +++K     +GS +V+ C+       +   WF  GNE++   K Q   
Sbjct: 7674 QVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGS-PPISVSWFHEGNEISSGRKYQTTL 7732

Query: 67   IQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
                     L +N    +DSG+Y C   +  G+D  SA +T+ E
Sbjct: 7733 TDNT---CALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVRE 7773



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 49/227 (21%), Positives = 85/227 (37%), Gaps = 34/227 (14%)

Query: 3    KGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKP 62
            K  +G +     P  + +  S++   GS + L+  T    + L  +WFK   EL      
Sbjct: 4194 KDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLK-STFQGSTPLTIRWFKGNKELVSGG-- 4250

Query: 63   QNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE------------ 110
             +  I K+  +S L +     +DSG Y CKV +  G    SAN+ + E            
Sbjct: 4251 -SCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQ 4309

Query: 111  ------SNATSTSTTGTSHL----------VKCAEKEKTFCVNGGECFMVKD--LSNPSR 152
                  +   +   TGT  +          +K + K +   V       + D  + +   
Sbjct: 4310 LLKKGDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGE 4369

Query: 153  YLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGI 199
            Y+C+  NE   D C + V+     +   EF   E L +  V+ +  +
Sbjct: 4370 YMCEAQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEV 4416



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 27/98 (27%), Positives = 48/98 (48%), Gaps = 5/98 (5%)

Query: 14   LPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
            +PP   K++K  +S  GS + L C  +  +  +  +WFK+  E++   K    K      
Sbjct: 4673 IPPSFTKKLKKMDSIKGSFIDLECIVAGSHP-ISIQWFKDDQEISASEK---YKFSFHDN 4728

Query: 73   KSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
             + L I++    DSG Y C   +K G++  S ++T+ E
Sbjct: 4729 TAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKE 4766



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 28/95 (29%), Positives = 48/95 (50%), Gaps = 4/95 (4%)

Query: 15    PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
             P  + + +SQ    G  ++  CE S E S    +WFKN   ++  +   N+ I +     
Sbjct: 33134 PAFISQPRSQNINEGQNVLFTCEISGEPSP-EIEWFKNNLPISISS---NVSISRSRNVY 33189

Query: 75    ELRINKASLADSGEYMCKVISKLGNDSASANITIV 109
              L I  AS++DSG+Y  K  +  G  SA+A++ ++
Sbjct: 33190 SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVL 33224



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 33/121 (27%), Positives = 57/121 (47%), Gaps = 5/121 (4%)

Query: 15   PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
            P  +KE++  +SA   K+ L C+   +   +   W K+G +L      ++ KI  +   +
Sbjct: 3644 PHFIKELEPVQSAINKKVHLECQVDED-RKVTVTWSKDGQKLP---PGKDYKICFEDKIA 3699

Query: 75   ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTF 134
             L I  A L DSG Y+C   ++ G+ S SA +T+ E   +       S+L+   E  +  
Sbjct: 3700 TLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREP-PSFVKKVDPSYLMLPGESARLH 3758

Query: 135  C 135
            C
Sbjct: 3759 C 3759



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 42/186 (22%), Positives = 72/186 (38%), Gaps = 33/186 (17%)

Query: 15   PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
            P  ++E+K  E    S + L CE +         W KN  E+    K     +  +    
Sbjct: 4955 PTFIRELKPVEVVKYSDVELECEVTGT-PPFEVTWLKNNREIRSSKK---YTLTDRVSVF 5010

Query: 75   ELRINKASLADSGEYMCKVISKLGNDSASANI----------------TIVESNATSTST 118
             L I K   +D+GEY C V ++ G+ S S  +                T+++S+AT  ST
Sbjct: 5011 NLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQST 5070

Query: 119  TGTSHLVKCA---------EKEKTFC--VNGGECFMVKDLSN--PSRYLCKCPNEFTGDR 165
               S  +            E +  +   V+      ++ + N    RY C+  NE   +R
Sbjct: 5071 VAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVER 5130

Query: 166  CQNYVM 171
            C  +++
Sbjct: 5131 CYAFLL 5136



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 32/116 (27%), Positives = 50/116 (43%), Gaps = 5/116 (4%)

Query: 11   TTALPPRLKEMKSQESAA-GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK 69
            T   PP   +  S   A  GS ++L+CE S         W K+  ++    K    KI  
Sbjct: 6453 TVKAPPVFTQKPSPVGALKGSDVILQCEISGT-PPFEVVWVKDRKQVRNSKK---FKITS 6508

Query: 70   KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLV 125
            K   + L I     +D GEY CK  +++G+D+ S ++   E        + TS L+
Sbjct: 6509 KHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKLSDTSTLI 6564



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 29/96 (30%), Positives = 53/96 (55%), Gaps = 6/96 (6%)

Query: 15   PPR-LKEMKSQESAA-GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
            PP+ +K++++ + A  G  + L C+ S     ++  WF+N +EL+   K     I     
Sbjct: 6363 PPKFVKKLEASKVAKQGESIQLECKISGS-PEIKVSWFRNDSELHESWKYNMSFINSV-- 6419

Query: 73   KSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
             + L IN+AS  DSG+Y+C+  + +G+ S S  +T+
Sbjct: 6420 -ALLTINEASAEDSGDYICEAHNGVGDASCSTALTV 6454



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 27/78 (34%), Positives = 40/78 (51%), Gaps = 10/78 (12%)

Query: 31    KLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM 90
             ++ L+CE S +   +  KWFK+G E+    K     I+    +  L+I KA L D GEY+
Sbjct: 11679 EITLKCEVSKD---VPVKWFKDGEEIVPSPK---YSIKADGLRRILKIKKADLKDKGEYV 11732

Query: 91    CKVISKLGNDSASANITI 108
             C      G D   AN+T+
Sbjct: 11733 C----DCGTDKTKANVTV 11746



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 24/89 (26%), Positives = 45/89 (50%), Gaps = 9/89 (10%)

Query: 45   LRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASA 104
            ++  WFKN  EL+  N    +++     ++ L I    + DSG Y C+ ++ +G+DS S 
Sbjct: 3767 IQVTWFKNNKELSESN---TVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCST 3823

Query: 105  NITI------VESNATSTSTTGTSHLVKC 127
             I I      +++   +    GT+ L++C
Sbjct: 3824 EIVIKEPPSFIKTLEPADIVRGTNALLQC 3852



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 23/90 (25%), Positives = 42/90 (46%), Gaps = 4/90 (4%)

Query: 29   GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGE 88
            G  + L C        +R +W K G E+   ++          G + L +   + ADSG+
Sbjct: 8360 GEYVQLSCHVQGS-EPIRIQWLKAGREIKPSDR---CSFSFASGTAVLELRDVAKADSGD 8415

Query: 89   YMCKVISKLGNDSASANITIVESNATSTST 118
            Y+CK  +  G+D+  + +TI +  A + +T
Sbjct: 8416 YVCKASNVAGSDTTKSKVTIKDKPAVAPAT 8445



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 37/177 (20%), Positives = 70/177 (39%), Gaps = 33/177 (18%)

Query: 19   KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 78
            K +++ +S       L C+ +     +R  WFK+G E+   ++    +I    G + L I
Sbjct: 4117 KPLRNVDSVVNGTCRLDCKIAGSLP-MRVSWFKDGKEIAASDR---YRIAFVEGTASLEI 4172

Query: 79   NKASLADSGEYMCKVISKLGNDSASANITIVE---------------SNATSTSTT--GT 121
             +  + D+G + C+  + +G+  +S  + + E                +A    +T  G+
Sbjct: 4173 IRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGS 4232

Query: 122  SHLVKCAEKEKTFCVNGGECFMVKD------------LSNPSRYLCKCPNEFTGDRC 166
            + L     K     V+GG C++ K+             S+   Y CK  N   G  C
Sbjct: 4233 TPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVEC 4289



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 35/127 (27%), Positives = 57/127 (44%), Gaps = 10/127 (7%)

Query: 9    VGTTAL--PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIK 66
            VG+ AL  PPR  +  S  S    K V    T      +   WFK+  E+ R++   NI 
Sbjct: 7483 VGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRES--DNIW 7540

Query: 67   IQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANI------TIVESNATSTSTTG 120
            I      + L+ ++   A++G+Y C++ +  G     A +      TIVE   +   TTG
Sbjct: 7541 ISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTG 7600

Query: 121  TSHLVKC 127
             +  ++C
Sbjct: 7601 DTCTLEC 7607



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 32/119 (26%), Positives = 57/119 (47%), Gaps = 13/119 (10%)

Query: 18   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
            +++ +S +   G    L C T +    L  KWFK+G EL   NK +     K  G   L+
Sbjct: 7589 VEKPESIKVTTGDTCTLEC-TVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSG---LK 7644

Query: 78   INKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST---------TGTSHLVKC 127
            I   + +DSG Y  +V + +G DS +A++ + +     + T         +G+S +++C
Sbjct: 7645 IINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMEC 7703



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 27/104 (25%), Positives = 50/104 (48%), Gaps = 5/104 (4%)

Query: 8    RVGTTALPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIK 66
            R+    LPP   +++K  E   G  + L C  +   + ++  W+++G  L      +N++
Sbjct: 6167 RIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGS-APIQVCWYRDGVLLR---DDENLQ 6222

Query: 67   IQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
                   + L+I +  L+ SG+Y C   + LG  S+SA +T  E
Sbjct: 6223 TSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTARE 6266



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 25/96 (26%), Positives = 46/96 (47%), Gaps = 4/96 (4%)

Query: 15   PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
            P  ++++K   +  G+ +VL C  S   + +   WF++GNE+    K Q+          
Sbjct: 6741 PSFIRKLKDVNAILGASVVLECRVSGS-APISVGWFQDGNEIVSGPKCQS---SFSENVC 6796

Query: 75   ELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
             L ++    +D+G Y C   +  G+D  SA +T+ E
Sbjct: 6797 TLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQE 6832



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 27/94 (28%), Positives = 47/94 (50%), Gaps = 4/94 (4%)

Query: 15   PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
            P  ++ ++  E+  G    L+C+       +R  W+K   +L  ++ P   K+Q K   +
Sbjct: 7020 PYFIEPLEHVEAVIGEPATLQCKVDGT-PEIRISWYKEHTKL--RSAPA-YKMQFKNNVA 7075

Query: 75   ELRINKASLADSGEYMCKVISKLGNDSASANITI 108
             L INK   +D GEY CK  + +G  ++SA + I
Sbjct: 7076 SLVINKVDHSDVGEYSCKADNSVGAVASSAVLVI 7109



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 28/110 (25%), Positives = 49/110 (44%), Gaps = 5/110 (4%)

Query: 2    GKGRAGRVGTTALPPR-LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
            G+   G + +T  PP  + E++  E+A G  + L+C+ +     +   W+K   +L    
Sbjct: 6065 GRDVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQVAGT-PEITVSWYKGDTKLR--- 6120

Query: 61   KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
                 +       + L  NK ++ DSGEY CK  + +G  S+     I E
Sbjct: 6121 PTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQE 6170



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 24/96 (25%), Positives = 46/96 (47%), Gaps = 4/96 (4%)

Query: 15   PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
            P  +K+++  + + G    L+C+ +     +   W+K   +L         K+  +   +
Sbjct: 7961 PYFVKQLEPVKVSVGDSASLQCQLAGT-PEIGVSWYKGDTKLRPTT---TYKMHFRNNVA 8016

Query: 75   ELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
             L  N+  + DSGEY+CK  + +G  SAS  +T+ E
Sbjct: 8017 TLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQE 8052



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 29/120 (24%), Positives = 56/120 (46%), Gaps = 10/120 (8%)

Query: 15   PPR-LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 73
            PPR +K++    +  G  + LR      +  +   W K+  E+ R++  +N +I      
Sbjct: 6550 PPRFVKKLSDTSTLIGDAVELRAIVEG-FQPISVVWLKDRGEVIRES--ENTRISFIDNI 6606

Query: 74   SELRINKASLADSGEYMCKVISKLGNDSASANIT------IVESNATSTSTTGTSHLVKC 127
            + L++     ++SG+Y+C++ +  G    SA +T      I+E     T TTG    ++C
Sbjct: 6607 ATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALEC 6666



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 24/105 (22%), Positives = 46/105 (43%), Gaps = 4/105 (3%)

Query: 25   ESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLA 84
            ++  G      C  +     ++  W K+  E+    K Q   ++     + L+++K    
Sbjct: 8163 DAVVGESADFECHVTGT-QPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKG--- 8218

Query: 85   DSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAE 129
            DSG+Y C  ++++G DS +A + I E     + T   S  V+  E
Sbjct: 8219 DSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETE 8263



 Score = 38.9 bits (89), Expect = 0.013
 Identities = 28/120 (23%), Positives = 49/120 (40%), Gaps = 6/120 (5%)

Query: 15   PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
            P  +  +K+     G  + L C  S  Y S    W++   ++       + +I  + G +
Sbjct: 943  PTLVSGLKNVTVIEGESVTLECHISG-YPSPTVTWYREDYQIESSI---DFQITFQSGIA 998

Query: 75   ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTF 134
             L I +A   DSG + C  +++ G  S S  + +  S      TT  +   K   +EK F
Sbjct: 999  RLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE--KFTTEEKRF 1056



 Score = 38.9 bits (89), Expect = 0.013
 Identities = 25/79 (31%), Positives = 39/79 (49%), Gaps = 6/79 (7%)

Query: 49    WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT- 107
             W K+G  + +  K    K+ +  G   L I+K   +DSG Y C V +  G+ S+S  +T 
Sbjct: 32885 WTKDGKAITQGGK---YKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 32941

Query: 108   --IVESNATSTSTTGTSHL 124
               I ++ A   ST  TS +
Sbjct: 32942 KAIKDTEAQKVSTQKTSEI 32960



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 23/63 (36%), Positives = 32/63 (50%), Gaps = 3/63 (4%)

Query: 48   KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 107
            KWFK+G EL   +K    KI      S L+I      DSGEY  +V + +G  S  A I 
Sbjct: 4611 KWFKDGQELTLGSK---YKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARIN 4667

Query: 108  IVE 110
            +++
Sbjct: 4668 VLD 4670



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 25/98 (25%), Positives = 51/98 (52%), Gaps = 6/98 (6%)

Query: 15   PPR-LKEMKSQESA-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
            PP+ +K++++ +   AG    L C+ +     +R  WF+N +EL   +K +   I     
Sbjct: 5422 PPKFVKKLEASKIVKAGDSSRLECKIAGS-PEIRVVWFRNEHELPASDKYRMTFIDSV-- 5478

Query: 73   KSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
             + +++N  S  DSG+++C+  +  G+ S S  + + E
Sbjct: 5479 -AVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKE 5515



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 25/99 (25%), Positives = 45/99 (45%), Gaps = 10/99 (10%)

Query: 12   TALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKP 71
            ++ PP ++ +K+ E +      L CE S         W+K+  +L    K    KI  K 
Sbjct: 5520 SSFPPIVETLKNAEVS------LECELSGT-PPFEVVWYKDKRQLRSSKK---YKIASKN 5569

Query: 72   GKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
              + + I     +D GEY CK  +++G+D+    + + E
Sbjct: 5570 FHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKE 5608



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 23/84 (27%), Positives = 37/84 (44%), Gaps = 4/84 (4%)

Query: 25   ESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLA 84
            E+  G+ + L CE           W+K+  EL    K    KI  +   + + I     A
Sbjct: 7409 ETLKGADVHLECELQGT-PPFHVSWYKDKRELRSGKK---YKIMSENFLTSIHILNVDAA 7464

Query: 85   DSGEYMCKVISKLGNDSASANITI 108
            D GEY CK  + +G+D+   +I +
Sbjct: 7465 DIGEYQCKATNDVGSDTCVGSIAL 7488



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 28/81 (34%), Positives = 38/81 (46%), Gaps = 9/81 (11%)

Query: 36    CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 95
             CE S E  + + KWFK+G E+ +  K     I  K     L INK  L D  EY C+V +
Sbjct: 12395 CELSRE--NAKVKWFKDGAEIKKGKK---YDIISKGAVRILVINKCLLDDEAEYSCEVRT 12449

Query: 96    KLGNDSASANITIVESNATST 116
                    S  +T++E  A  T
Sbjct: 12450 A----RTSGMLTVLEEEAVFT 12466



 Score = 38.1 bits (87), Expect = 0.023
 Identities = 31/106 (29%), Positives = 47/106 (44%), Gaps = 4/106 (3%)

Query: 19   KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 78
            KE K  E      ++L  E +         WFK+ N + R  +     IQ       L+I
Sbjct: 4397 KEFKPIEVLKEYDVMLLAEVAGT-PPFEITWFKD-NTILRSGRKYKTFIQDH--LVSLQI 4452

Query: 79   NKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHL 124
             K   AD+GEY C+V +++G+   SA +T+ E  +       TS L
Sbjct: 4453 LKFVAADAGEYQCRVTNEVGSSICSARVTLREPPSFIKKIESTSSL 4498



 Score = 37.7 bits (86), Expect = 0.030
 Identities = 18/70 (25%), Positives = 31/70 (44%)

Query: 49    WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
             W+K+G ++   +  +    +   G  +L IN  +  D  EY     +K G DS  A +T+
Sbjct: 31723 WYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 31782

Query: 109   VESNATSTST 118
                   + ST
Sbjct: 31783 TLHPPPTDST 31792



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 23/83 (27%), Positives = 34/83 (40%), Gaps = 4/83 (4%)

Query: 28   AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSG 87
            AG      C  +     +R  W K+  E+       N  I        LRI K    DSG
Sbjct: 6284 AGESADFECHVTGA-QPMRITWSKDNKEIRPGG---NYTITCVGNTPHLRILKVGKGDSG 6339

Query: 88   EYMCKVISKLGNDSASANITIVE 110
            +Y C+  + +G D  SA +++ E
Sbjct: 6340 QYTCQATNDVGKDMCSAQLSVKE 6362



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 26/92 (28%), Positives = 43/92 (46%), Gaps = 8/92 (8%)

Query: 15    PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFK---WFKNGNELNRKNKPQNIKIQKKP 71
             PP++ +    E+   SK + +     E S LR K   W+K+G +L      Q        
Sbjct: 32717 PPKITQFLKAEA---SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH--YSAD 32771

Query: 72    GKSELRINKASLADSGEYMCKVISKLGNDSAS 103
             G  EL+IN  + +D GEY+C++  + G    +
Sbjct: 32772 GTYELKINNLTESDQGEYVCEISGEGGTSKTN 32803



 Score = 37.0 bits (84), Expect = 0.051
 Identities = 26/99 (26%), Positives = 45/99 (45%), Gaps = 6/99 (6%)

Query: 14   LPPRLKEMKSQ--ESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKP 71
            +PP   +  S+  E   G+   L    +     +   W+KN  E+   +   N +I  K 
Sbjct: 8247 IPPSFTKRLSETVEETEGNSFKLEGRVAGS-QPITVAWYKNNIEIQPTS---NCEITFKN 8302

Query: 72   GKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
                L++ KA + D+G Y CKV +  G+   +++I I E
Sbjct: 8303 NTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKE 8341



 Score = 36.2 bits (82), Expect = 0.087
 Identities = 28/108 (25%), Positives = 47/108 (43%), Gaps = 5/108 (4%)

Query: 2    GKGRAGRVGTTALPPRLKEMKSQESAA-GSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
            G      V T   P R+ E     +   G+   L C  +     L  KWFK+G EL+  +
Sbjct: 6631 GMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVVTGT-PELSAKWFKDGRELSADS 6689

Query: 61   KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
            K     I K    + L+I  A ++D G Y  +V + +G  + + ++ +
Sbjct: 6690 KHHITFINK---VASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHV 6734



 Score = 35.4 bits (80), Expect = 0.15
 Identities = 28/101 (27%), Positives = 42/101 (41%), Gaps = 5/101 (4%)

Query: 11   TTALPPR-LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK 69
            T A PP  L   KS  +  G      C T +    +   W K+G  L+      N +I  
Sbjct: 3546 TEAYPPTFLSRPKSLTTFVGKAAKFIC-TVTGTPVIETIWQKDGAALSPS---PNWRISD 3601

Query: 70   KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
               K  L ++  ++ D G Y CK  +K G D   A + I++
Sbjct: 3602 AENKHILELSNLTIQDRGVYSCKASNKFGADICQAELIIID 3642



 Score = 35.4 bits (80), Expect = 0.15
 Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 2/43 (4%)

Query: 19    KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNK 61
             K ++ Q    G+  VL CE S E  + + KWFKNG E+ +  K
Sbjct: 12289 KPLEDQTVEEGATAVLECEVSRE--NAKVKWFKNGTEILKSKK 12329



 Score = 35.0 bits (79), Expect = 0.19
 Identities = 26/96 (27%), Positives = 43/96 (44%), Gaps = 4/96 (4%)

Query: 15   PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
            P  +K ++  +   G+  +L+CE S         WFK+  ++ R +K   +  QK     
Sbjct: 3831 PSFIKTLEPADIVRGTNALLQCEVSGT-GPFEISWFKDKKQI-RSSKKYRLFSQKS--LV 3886

Query: 75   ELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
             L I   + AD GEY C V +++G     A   + E
Sbjct: 3887 CLEIFSFNSADVGEYECVVANEVGKCGCMATHLLKE 3922



 Score = 35.0 bits (79), Expect = 0.19
 Identities = 30/120 (25%), Positives = 54/120 (45%), Gaps = 10/120 (8%)

Query: 15   PPR-LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 73
            PPR + ++ S    AG    L+         +  +W K   E+ R++  +NI+I      
Sbjct: 5609 PPRFVSKLNSLTVVAGEPAELQASIEGA-QPIFVQWLKEKEEVIRES--ENIRITFVENV 5665

Query: 74   SELRINKASLADSGEYMCKVISKLGNDSASANI------TIVESNATSTSTTGTSHLVKC 127
            + L+  KA  A++G+Y+C++ +  G     A +       IVE     T T G +  ++C
Sbjct: 5666 ATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVGETCTLEC 5725



 Score = 35.0 bits (79), Expect = 0.19
 Identities = 24/103 (23%), Positives = 42/103 (40%), Gaps = 5/103 (4%)

Query: 9    VGTTALPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 67
            V   A+PP   + +K+     G+  +L C+ +   S +   WF    ++    K Q    
Sbjct: 5793 VSDRAVPPSFTRRLKNTGGVLGASCILECKVAGS-SPISVAWFHEKTKIVSGAKYQTTF- 5850

Query: 68   QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
                    L++N    +D G Y C   +  G+D   A +T+ E
Sbjct: 5851 --SDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQE 5891



 Score = 35.0 bits (79), Expect = 0.19
 Identities = 25/93 (26%), Positives = 40/93 (43%), Gaps = 4/93 (4%)

Query: 18   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
            +K +       G  L+L   T +    +   W KNG  +      Q   I      + L 
Sbjct: 7871 VKRLNDYSIEKGKPLILE-GTFTGTPPISVTWKKNGINVTPS---QRCNITTTEKSAILE 7926

Query: 78   INKASLADSGEYMCKVISKLGNDSASANITIVE 110
            I  +++ D+G+Y C + +  G DS SA I I+E
Sbjct: 7927 IPSSTVEDAGQYNCYIENASGKDSCSAQILILE 7959



 Score = 34.3 bits (77), Expect = 0.33
 Identities = 28/117 (23%), Positives = 46/117 (39%), Gaps = 5/117 (4%)

Query: 23   SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKAS 82
            S + A G     +C  +   + ++  W K+  E+       N K+      + L + K  
Sbjct: 7220 SVDLALGESGTFKCHVTGT-APIKITWAKDNREIRPGG---NYKMTLVENTATLTVLKVG 7275

Query: 83   LADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGG 139
              D+G+Y C   +  G DS SA + + E           S +VK  E  +  C  GG
Sbjct: 7276 KGDAGQYTCYASNIAGKDSCSAQLGVQEP-PRFIKKLEPSRIVKQDEFTRYECKIGG 7331



 Score = 33.9 bits (76), Expect = 0.43
 Identities = 29/103 (28%), Positives = 43/103 (41%), Gaps = 7/103 (6%)

Query: 19   KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 78
            K +  Q  A   + V  CE ++  S  + +W ++G  L   N   NI+ +    K  L I
Sbjct: 2624 KPLTDQTVAESQEAVFECEVANPDS--KGEWLRDGKHLPLTN---NIRSESDGHKRRLII 2678

Query: 79   NKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGT 121
                L D GEY  KV +     SA   +  V+   T  + T T
Sbjct: 2679 AATKLDDIGEYTYKVAT--SKTSAKLKVEAVKIKKTLKNLTVT 2719



 Score = 33.9 bits (76), Expect = 0.43
 Identities = 24/101 (23%), Positives = 46/101 (45%), Gaps = 5/101 (4%)

Query: 11   TTALPPRLKEM-KSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK 69
            T   PP   E  +SQ+    +++ L+       + +  KWFK+  EL+         + K
Sbjct: 4763 TVKEPPYFVEKPQSQDVNPNTRVQLKALVGGT-APMTIKWFKDNKELHSGAARS---VWK 4818

Query: 70   KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
                + L +  A   DSG Y+C++ + +G  ++ A + + E
Sbjct: 4819 DDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKE 4859



 Score = 33.9 bits (76), Expect = 0.43
 Identities = 21/101 (20%), Positives = 42/101 (41%), Gaps = 3/101 (2%)

Query: 8     RVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 67
             +V +  + P   ++       G  +   C+  +   S +  W+    +L    K    +I
Sbjct: 31561 KVASIEIGPVSGQIMHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEK---YEI 31617

Query: 68    QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
               + G + L +   +  D G Y CKV++  G DS+ A + +
Sbjct: 31618 TYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFV 31658



 Score = 33.5 bits (75), Expect = 0.56
 Identities = 26/97 (26%), Positives = 43/97 (44%), Gaps = 2/97 (2%)

Query: 10   GTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK 69
            G  A P  + +   Q+   G  +V  C+         + W K+G  L    +   +   K
Sbjct: 1077 GEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVY-WKKSGVPLTTGYR-YKVSYNK 1134

Query: 70   KPGKSELRINKASLADSGEYMCKVISKLGNDSASANI 106
            + G+ +L I+     D+GEY   V +K G  SASA++
Sbjct: 1135 QTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1171



 Score = 33.5 bits (75), Expect = 0.56
 Identities = 30/121 (24%), Positives = 49/121 (40%), Gaps = 5/121 (4%)

Query: 29   GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGE 88
            G      C+ +     +R  W+ +GNE+    K     I    G +  +I+ A + +SG 
Sbjct: 4876 GQSTTFECQITGT-PKIRVSWYLDGNEITAIQKHG---ISFIDGLATFQISGARVENSGT 4931

Query: 89   YMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLS 148
            Y+C+  +  G  S S  + + E   T         +VK ++ E    V G   F V  L 
Sbjct: 4932 YVCEARNDAGTASCSIELKVKEP-PTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLK 4990

Query: 149  N 149
            N
Sbjct: 4991 N 4991



 Score = 33.1 bits (74), Expect = 0.73
 Identities = 26/101 (25%), Positives = 41/101 (40%), Gaps = 25/101 (24%)

Query: 18   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
            LK++ ++E     K  +  E +  Y  + +KW KNG E+   +K Q   ++ K     L 
Sbjct: 2975 LKDINAEE-----KDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQ---MRTKKLTHSLN 3026

Query: 78   INKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST 118
            I      D+ +Y                 T V   ATST+T
Sbjct: 3027 IRNVHFGDAADY-----------------TFVAGKATSTAT 3050



 Score = 33.1 bits (74), Expect = 0.73
 Identities = 26/96 (27%), Positives = 44/96 (45%), Gaps = 11/96 (11%)

Query: 18    LKEMK----SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 73
             +KE+K    ++    GS  +  C  S   S+    W K+G+ +    K + I   K    
Sbjct: 11118 VKEIKDIILTESEFVGSSAIFECLVSP--STAITTWMKDGSNIRESPKHRFIADGKD--- 11172

Query: 74    SELRINKASLADSGEYMCKVISKLGNDSASANITIV 109
              +L I    L+D+GEY C  + +LGN   ++   +V
Sbjct: 11173 RKLHIIDVQLSDAGEYTC--VLRLGNKEKTSTAKLV 11206



 Score = 32.7 bits (73), Expect = 0.96
 Identities = 15/66 (22%), Positives = 35/66 (53%), Gaps = 3/66 (4%)

Query: 45   LRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASA 104
            ++  W+K+  E+   +K    ++      + L ++  S+ DSG+Y C+  +  G+ S+S 
Sbjct: 7335 IKVLWYKDETEIQESSK---FRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSST 7391

Query: 105  NITIVE 110
            ++ + E
Sbjct: 7392 SLKVKE 7397



 Score = 32.7 bits (73), Expect = 0.96
 Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 5/76 (6%)

Query: 18    LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
             ++ ++ Q        V  C+ S E +++  KW++NG E+    K    K +K      L 
Sbjct: 12826 VEHLEDQTVTEFDDAVFSCQLSREKANV--KWYRNGREIKEGKK---YKFEKDGSIHRLI 12880

Query: 78    INKASLADSGEYMCKV 93
             I    L D  EY C V
Sbjct: 12881 IKDCRLDDECEYACGV 12896



 Score = 32.7 bits (73), Expect = 0.96
 Identities = 16/61 (26%), Positives = 34/61 (55%), Gaps = 3/61 (4%)

Query: 49    WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
             W K+G E+   ++   + ++     + L + K+  AD+G Y   + +KLG+ +AS N+ +
Sbjct: 14420 WHKDGKEVKASDR---LTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKV 14476

Query: 109   V 109
             +
Sbjct: 14477 I 14477



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 26/117 (22%), Positives = 42/117 (35%), Gaps = 4/117 (3%)

Query: 3     KGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKP 62
             K    ++ TT     L + +S     G      C+T  E       W + G  L+   + 
Sbjct: 32549 KSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPT-VTWLRKGQVLSTSARH 32607

Query: 63    QNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTT 119
             Q   +     KS   I+    +D G Y   V +  G   A   +TI ++  T  + T
Sbjct: 32608 Q---VTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVT 32661



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 23/94 (24%), Positives = 39/94 (41%), Gaps = 4/94 (4%)

Query: 46   RFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASAN 105
            + KWFK+  EL    K     I  +   S L +     + +G+Y C V + +G+DS +  
Sbjct: 5360 KIKWFKDDVELVSGPK---CFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTM 5416

Query: 106  ITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGG 139
            + + E           S +VK  +  +  C   G
Sbjct: 5417 LLVTEP-PKFVKKLEASKIVKAGDSSRLECKIAG 5449



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 24/102 (23%), Positives = 46/102 (45%), Gaps = 3/102 (2%)

Query: 8     RVGTTALPPRLKEMKSQESA-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIK 66
             + G   +PP+++ + S  S   G  L + C  + E +     W   G +++ + + +   
Sbjct: 33321 KAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTP-EVTWSCGGRKIHSQEQGR-FH 33378

Query: 67    IQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
             I+     + L I      D G Y   + ++ G+DSA+ NI I
Sbjct: 33379 IENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 33420



 Score = 31.2 bits (69), Expect = 2.8
 Identities = 27/93 (29%), Positives = 42/93 (45%), Gaps = 8/93 (8%)

Query: 18    LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
             LK+ + +E     ++V  CE ++E    + KWF+N   +   +K     I +K     LR
Sbjct: 12646 LKDTRVKEQ---QEVVFNCEVNTE--GAKAKWFRNEEAIFDSSK---YIILQKDLVYTLR 12697

Query: 78    INKASLADSGEYMCKVISKLGNDSASANITIVE 110
             I  A L D   Y   + +  G +  SA   IVE
Sbjct: 12698 IRDAHLDDQANYNVSLTNHRGENVKSAANLIVE 12730



 Score = 30.8 bits (68), Expect = 3.6
 Identities = 20/93 (21%), Positives = 40/93 (43%), Gaps = 4/93 (4%)

Query: 18   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
            LK +       G  ++L   T +    +   W K+G  +    K   +  +K      L 
Sbjct: 5989 LKRLSDHSVEPGKSIILE-STYTGTLPISVTWKKDGFNITTSEKCNIVTTEKT---CILE 6044

Query: 78   INKASLADSGEYMCKVISKLGNDSASANITIVE 110
            I  ++  D+G+Y C++ ++ G D   A ++ +E
Sbjct: 6045 ILNSTKRDAGQYSCEIENEAGRDVCGALVSTLE 6077



 Score = 30.8 bits (68), Expect = 3.6
 Identities = 17/65 (26%), Positives = 32/65 (49%), Gaps = 3/65 (4%)

Query: 46   RFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASAN 105
            + KWFK   EL      ++  I  +   +EL + +    +SG+Y C V +  G+ S + +
Sbjct: 6864 KVKWFKGSRELV---PGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTH 6920

Query: 106  ITIVE 110
            + + E
Sbjct: 6921 LFVKE 6925



 Score = 30.8 bits (68), Expect = 3.6
 Identities = 25/101 (24%), Positives = 44/101 (43%), Gaps = 7/101 (6%)

Query: 11    TTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNI-KIQK 69
             T  L P +K+  + +  AG  +VL   +       +  W K G ++    +P +I +I  
Sbjct: 20377 TIVLDPTIKDGLTIK--AGDTIVLNAISILGKPLPKSSWSKAGKDI----RPSDITQITS 20430

Query: 70    KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
              P  S L I  A+  D+GEY     +  G       +T+++
Sbjct: 20431 TPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLD 20471



 Score = 30.4 bits (67), Expect = 4.8
 Identities = 17/68 (25%), Positives = 31/68 (45%), Gaps = 3/68 (4%)

Query: 46   RFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASAN 105
            +  WF+   EL + ++     I  +   +EL +    ++ SGEY C V +  G  S +  
Sbjct: 5923 KVNWFRGARELVKGDR---CNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTR 5979

Query: 106  ITIVESNA 113
            + + E  A
Sbjct: 5980 LFVKEPAA 5987



 Score = 30.0 bits (66), Expect = 6.2
 Identities = 38/171 (22%), Positives = 61/171 (35%), Gaps = 36/171 (21%)

Query: 29   GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGE 88
            G    L C+ +     L  +W+K+G  L    K +     K    S LRI      D+G 
Sbjct: 5718 GETCTLECKVAGT-PELSVEWYKDGKLLTSSQKHKFSFYNKI---SSLRILSVERQDAGT 5773

Query: 89   YMCKVISKLGNDSASANITIVESNATSTST---------TGTSHLVKCAE---------- 129
            Y  +V + +G  S +A + + +     + T          G S +++C            
Sbjct: 5774 YTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAW 5833

Query: 130  -KEKTFCVNGGE---------CFM---VKDLSNPSRYLCKCPNEFTGDRCQ 167
              EKT  V+G +         C +     D S+   Y C   N    D C+
Sbjct: 5834 FHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECR 5884



 Score = 29.6 bits (65), Expect = 8.1
 Identities = 16/63 (25%), Positives = 31/63 (49%), Gaps = 2/63 (3%)

Query: 48   KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 107
            KW K   +  + N+   + I +K  +++L I   +  DSG Y C   ++ G   ++ N+ 
Sbjct: 8486 KWTKG--KWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQ 8543

Query: 108  IVE 110
            + E
Sbjct: 8544 VDE 8546



 Score = 29.6 bits (65), Expect = 8.1
 Identities = 14/62 (22%), Positives = 31/62 (50%), Gaps = 1/62 (1%)

Query: 49    WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
             W K+ +  +    P+ +KI  +   S+  + KA  +D G+Y+    +  G+  A A + +
Sbjct: 18235 WTKDKDATDLTRSPR-VKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNV 18293

Query: 109   VE 110
             ++
Sbjct: 18294 LD 18295


>gi|221316757 neurotrimin isoform 3 [Homo sapiens]
          Length = 355

 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 38/126 (30%), Positives = 56/126 (44%), Gaps = 12/126 (9%)

Query: 11  TTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 70
           T   PP + E K      G K  L+CE S+   S  F+W+K+   L    K   +K++ +
Sbjct: 218 TVNYPPYISEAKGTGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK--GVKVENR 274

Query: 71  PGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVES---------NATSTSTTGT 121
           P  S+L     S  D G Y C   +KLG+ +AS  +  V++          A S  + GT
Sbjct: 275 PFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFEVKTTALTPWKGPGAVSEVSNGT 334

Query: 122 SHLVKC 127
           S    C
Sbjct: 335 SRRAGC 340


>gi|45594240 limbic system-associated membrane protein [Homo
           sapiens]
          Length = 338

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 28/93 (30%), Positives = 47/93 (50%), Gaps = 4/93 (4%)

Query: 11  TTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 70
           T   PP + E KS E+  G +  L+CE S+   +  F+W+++   +N  N    ++I+  
Sbjct: 214 TVNYPPTITESKSNEATTGRQASLKCEASA-VPAPDFEWYRDDTRINSAN---GLEIKST 269

Query: 71  PGKSELRINKASLADSGEYMCKVISKLGNDSAS 103
            G+S L +   +    G Y C   +KLG  +AS
Sbjct: 270 EGQSSLTVTNVTEEHYGNYTCVAANKLGVTNAS 302


>gi|221316762 neurotrimin isoform 4 [Homo sapiens]
          Length = 316

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 31/93 (33%), Positives = 45/93 (48%), Gaps = 3/93 (3%)

Query: 11  TTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 70
           T   PP + E K      G K  L+CE S+   S  F+W+K+   L    K   +K++ +
Sbjct: 218 TVNYPPYISEAKGTGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK--GVKVENR 274

Query: 71  PGKSELRINKASLADSGEYMCKVISKLGNDSAS 103
           P  S+L     S  D G Y C   +KLG+ +AS
Sbjct: 275 PFLSKLIFFNVSEHDYGNYTCVASNKLGHTNAS 307


>gi|110349717 titin isoform novex-2 [Homo sapiens]
          Length = 27118

 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 30/96 (31%), Positives = 48/96 (50%), Gaps = 4/96 (4%)

Query: 13   ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
            A P   ++++  E A G      CE  S   ++RF+WFK G E+   +K     I+    
Sbjct: 4527 AAPVIKRKIEPLEVALGHLAKFTCEIQSA-PNVRFQWFKAGREIYESDK---CSIRSSKY 4582

Query: 73   KSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
             S L I +  + D GEY CK  ++ G+ S +A +T+
Sbjct: 4583 ISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 4618



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 28/95 (29%), Positives = 48/95 (50%), Gaps = 4/95 (4%)

Query: 15    PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
             P  + + +SQ    G  ++  CE S E S    +WFKN   ++  +   N+ I +     
Sbjct: 26829 PAFISQPRSQNINEGQNVLFTCEISGEPSP-EIEWFKNNLPISISS---NVSISRSRNVY 26884

Query: 75    ELRINKASLADSGEYMCKVISKLGNDSASANITIV 109
              L I  AS++DSG+Y  K  +  G  SA+A++ ++
Sbjct: 26885 SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVL 26919



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 27/78 (34%), Positives = 40/78 (51%), Gaps = 10/78 (12%)

Query: 31   KLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM 90
            ++ L+CE S +   +  KWFK+G E+    K     I+    +  L+I KA L D GEY+
Sbjct: 5374 EITLKCEVSKD---VPVKWFKDGEEIVPSPK---YSIKADGLRRILKIKKADLKDKGEYV 5427

Query: 91   CKVISKLGNDSASANITI 108
            C      G D   AN+T+
Sbjct: 5428 C----DCGTDKTKANVTV 5441



 Score = 38.9 bits (89), Expect = 0.013
 Identities = 28/120 (23%), Positives = 49/120 (40%), Gaps = 6/120 (5%)

Query: 15   PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
            P  +  +K+     G  + L C  S  Y S    W++   ++       + +I  + G +
Sbjct: 897  PTLVSGLKNVTVIEGESVTLECHISG-YPSPTVTWYREDYQIESSI---DFQITFQSGIA 952

Query: 75   ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTF 134
             L I +A   DSG + C  +++ G  S S  + +  S      TT  +   K   +EK F
Sbjct: 953  RLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE--KFTTEEKRF 1010



 Score = 38.9 bits (89), Expect = 0.013
 Identities = 25/79 (31%), Positives = 39/79 (49%), Gaps = 6/79 (7%)

Query: 49    WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT- 107
             W K+G  + +  K    K+ +  G   L I+K   +DSG Y C V +  G+ S+S  +T 
Sbjct: 26580 WTKDGKAITQGGK---YKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 26636

Query: 108   --IVESNATSTSTTGTSHL 124
               I ++ A   ST  TS +
Sbjct: 26637 KAIKDTEAQKVSTQKTSEI 26655



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 28/81 (34%), Positives = 38/81 (46%), Gaps = 9/81 (11%)

Query: 36   CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 95
            CE S E  + + KWFK+G E+ +  K     I  K     L INK  L D  EY C+V +
Sbjct: 6090 CELSRE--NAKVKWFKDGAEIKKGKK---YDIISKGAVRILVINKCLLDDEAEYSCEVRT 6144

Query: 96   KLGNDSASANITIVESNATST 116
                   S  +T++E  A  T
Sbjct: 6145 A----RTSGMLTVLEEEAVFT 6161



 Score = 37.7 bits (86), Expect = 0.030
 Identities = 18/70 (25%), Positives = 31/70 (44%)

Query: 49    WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
             W+K+G ++   +  +    +   G  +L IN  +  D  EY     +K G DS  A +T+
Sbjct: 25418 WYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 25477

Query: 109   VESNATSTST 118
                   + ST
Sbjct: 25478 TLHPPPTDST 25487



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 26/92 (28%), Positives = 43/92 (46%), Gaps = 8/92 (8%)

Query: 15    PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFK---WFKNGNELNRKNKPQNIKIQKKP 71
             PP++ +    E+   SK + +     E S LR K   W+K+G +L      Q        
Sbjct: 26412 PPKITQFLKAEA---SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH--YSAD 26466

Query: 72    GKSELRINKASLADSGEYMCKVISKLGNDSAS 103
             G  EL+IN  + +D GEY+C++  + G    +
Sbjct: 26467 GTYELKINNLTESDQGEYVCEISGEGGTSKTN 26498



 Score = 35.4 bits (80), Expect = 0.15
 Identities = 27/111 (24%), Positives = 42/111 (37%), Gaps = 3/111 (2%)

Query: 8    RVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 67
            ++G    P  LKE+K    A G   +       E +     WFK   +L          I
Sbjct: 3760 KLGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPT-VTWFKENKQLC--TSVYYTII 3816

Query: 68   QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST 118
                G     +N     DSG Y+CK  + LG  + +A + ++  +   T T
Sbjct: 3817 HNPNGSGTFIVNDPQREDSGLYICKAENMLGESTCAAELLVLLEDTDMTDT 3867



 Score = 35.4 bits (80), Expect = 0.15
 Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 2/43 (4%)

Query: 19   KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNK 61
            K ++ Q    G+  VL CE S E  + + KWFKNG E+ +  K
Sbjct: 5984 KPLEDQTVEEGATAVLECEVSRE--NAKVKWFKNGTEILKSKK 6024



 Score = 33.9 bits (76), Expect = 0.43
 Identities = 29/103 (28%), Positives = 43/103 (41%), Gaps = 7/103 (6%)

Query: 19   KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 78
            K +  Q  A   + V  CE ++  S  + +W ++G  L   N   NI+ +    K  L I
Sbjct: 2578 KPLTDQTVAESQEAVFECEVANPDS--KGEWLRDGKHLPLTN---NIRSESDGHKRRLII 2632

Query: 79   NKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGT 121
                L D GEY  KV +     SA   +  V+   T  + T T
Sbjct: 2633 AATKLDDIGEYTYKVAT--SKTSAKLKVEAVKIKKTLKNLTVT 2673



 Score = 33.9 bits (76), Expect = 0.43
 Identities = 21/101 (20%), Positives = 42/101 (41%), Gaps = 3/101 (2%)

Query: 8     RVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 67
             +V +  + P   ++       G  +   C+  +   S +  W+    +L    K    +I
Sbjct: 25256 KVASIEIGPVSGQIMHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEK---YEI 25312

Query: 68    QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
               + G + L +   +  D G Y CKV++  G DS+ A + +
Sbjct: 25313 TYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFV 25353



 Score = 33.5 bits (75), Expect = 0.56
 Identities = 26/97 (26%), Positives = 43/97 (44%), Gaps = 2/97 (2%)

Query: 10   GTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK 69
            G  A P  + +   Q+   G  +V  C+         + W K+G  L    +   +   K
Sbjct: 1031 GEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVY-WKKSGVPLTTGYR-YKVSYNK 1088

Query: 70   KPGKSELRINKASLADSGEYMCKVISKLGNDSASANI 106
            + G+ +L I+     D+GEY   V +K G  SASA++
Sbjct: 1089 QTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1125



 Score = 33.1 bits (74), Expect = 0.73
 Identities = 26/101 (25%), Positives = 41/101 (40%), Gaps = 25/101 (24%)

Query: 18   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
            LK++ ++E     K  +  E +  Y  + +KW KNG E+   +K Q   ++ K     L 
Sbjct: 2929 LKDINAEE-----KDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQ---MRTKKLTHSLN 2980

Query: 78   INKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST 118
            I      D+ +Y                 T V   ATST+T
Sbjct: 2981 IRNVHFGDAADY-----------------TFVAGKATSTAT 3004



 Score = 33.1 bits (74), Expect = 0.73
 Identities = 26/96 (27%), Positives = 44/96 (45%), Gaps = 11/96 (11%)

Query: 18   LKEMK----SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 73
            +KE+K    ++    GS  +  C  S   S+    W K+G+ +    K + I   K    
Sbjct: 4813 VKEIKDIILTESEFVGSSAIFECLVSP--STAITTWMKDGSNIRESPKHRFIADGKD--- 4867

Query: 74   SELRINKASLADSGEYMCKVISKLGNDSASANITIV 109
             +L I    L+D+GEY C  + +LGN   ++   +V
Sbjct: 4868 RKLHIIDVQLSDAGEYTC--VLRLGNKEKTSTAKLV 4901



 Score = 32.7 bits (73), Expect = 0.96
 Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 5/76 (6%)

Query: 18   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
            ++ ++ Q        V  C+ S E +++  KW++NG E+    K    K +K      L 
Sbjct: 6521 VEHLEDQTVTEFDDAVFSCQLSREKANV--KWYRNGREIKEGKK---YKFEKDGSIHRLI 6575

Query: 78   INKASLADSGEYMCKV 93
            I    L D  EY C V
Sbjct: 6576 IKDCRLDDECEYACGV 6591



 Score = 32.7 bits (73), Expect = 0.96
 Identities = 16/61 (26%), Positives = 34/61 (55%), Gaps = 3/61 (4%)

Query: 49   WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
            W K+G E+   ++   + ++     + L + K+  AD+G Y   + +KLG+ +AS N+ +
Sbjct: 8115 WHKDGKEVKASDR---LTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKV 8171

Query: 109  V 109
            +
Sbjct: 8172 I 8172



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 26/117 (22%), Positives = 42/117 (35%), Gaps = 4/117 (3%)

Query: 3     KGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKP 62
             K    ++ TT     L + +S     G      C+T  E       W + G  L+   + 
Sbjct: 26244 KSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPT-VTWLRKGQVLSTSARH 26302

Query: 63    QNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTT 119
             Q   +     KS   I+    +D G Y   V +  G   A   +TI ++  T  + T
Sbjct: 26303 Q---VTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVT 26356



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 24/102 (23%), Positives = 46/102 (45%), Gaps = 3/102 (2%)

Query: 8     RVGTTALPPRLKEMKSQESA-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIK 66
             + G   +PP+++ + S  S   G  L + C  + E +     W   G +++ + + +   
Sbjct: 27016 KAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTP-EVTWSCGGRKIHSQEQGR-FH 27073

Query: 67    IQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
             I+     + L I      D G Y   + ++ G+DSA+ NI I
Sbjct: 27074 IENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 27115



 Score = 31.2 bits (69), Expect = 2.8
 Identities = 27/93 (29%), Positives = 42/93 (45%), Gaps = 8/93 (8%)

Query: 18   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
            LK+ + +E     ++V  CE ++E    + KWF+N   +   +K     I +K     LR
Sbjct: 6341 LKDTRVKEQ---QEVVFNCEVNTE--GAKAKWFRNEEAIFDSSK---YIILQKDLVYTLR 6392

Query: 78   INKASLADSGEYMCKVISKLGNDSASANITIVE 110
            I  A L D   Y   + +  G +  SA   IVE
Sbjct: 6393 IRDAHLDDQANYNVSLTNHRGENVKSAANLIVE 6425



 Score = 30.8 bits (68), Expect = 3.6
 Identities = 25/101 (24%), Positives = 44/101 (43%), Gaps = 7/101 (6%)

Query: 11    TTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNI-KIQK 69
             T  L P +K+  + +  AG  +VL   +       +  W K G ++    +P +I +I  
Sbjct: 14072 TIVLDPTIKDGLTIK--AGDTIVLNAISILGKPLPKSSWSKAGKDI----RPSDITQITS 14125

Query: 70    KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
              P  S L I  A+  D+GEY     +  G       +T+++
Sbjct: 14126 TPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLD 14166



 Score = 29.6 bits (65), Expect = 8.1
 Identities = 14/62 (22%), Positives = 31/62 (50%), Gaps = 1/62 (1%)

Query: 49    WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
             W K+ +  +    P+ +KI  +   S+  + KA  +D G+Y+    +  G+  A A + +
Sbjct: 11930 WTKDKDATDLTRSPR-VKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNV 11988

Query: 109   VE 110
             ++
Sbjct: 11989 LD 11990


>gi|110349713 titin isoform novex-1 [Homo sapiens]
          Length = 27051

 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 30/96 (31%), Positives = 48/96 (50%), Gaps = 4/96 (4%)

Query: 13   ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
            A P   ++++  E A G      CE  S   ++RF+WFK G E+   +K     I+    
Sbjct: 4460 AAPVIKRKIEPLEVALGHLAKFTCEIQSA-PNVRFQWFKAGREIYESDK---CSIRSSKY 4515

Query: 73   KSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
             S L I +  + D GEY CK  ++ G+ S +A +T+
Sbjct: 4516 ISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 4551



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 28/95 (29%), Positives = 48/95 (50%), Gaps = 4/95 (4%)

Query: 15    PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
             P  + + +SQ    G  ++  CE S E S    +WFKN   ++  +   N+ I +     
Sbjct: 26762 PAFISQPRSQNINEGQNVLFTCEISGEPSP-EIEWFKNNLPISISS---NVSISRSRNVY 26817

Query: 75    ELRINKASLADSGEYMCKVISKLGNDSASANITIV 109
              L I  AS++DSG+Y  K  +  G  SA+A++ ++
Sbjct: 26818 SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVL 26852



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 27/78 (34%), Positives = 40/78 (51%), Gaps = 10/78 (12%)

Query: 31   KLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM 90
            ++ L+CE S +   +  KWFK+G E+    K     I+    +  L+I KA L D GEY+
Sbjct: 5307 EITLKCEVSKD---VPVKWFKDGEEIVPSPK---YSIKADGLRRILKIKKADLKDKGEYV 5360

Query: 91   CKVISKLGNDSASANITI 108
            C      G D   AN+T+
Sbjct: 5361 C----DCGTDKTKANVTV 5374



 Score = 38.9 bits (89), Expect = 0.013
 Identities = 28/120 (23%), Positives = 49/120 (40%), Gaps = 6/120 (5%)

Query: 15   PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
            P  +  +K+     G  + L C  S  Y S    W++   ++       + +I  + G +
Sbjct: 897  PTLVSGLKNVTVIEGESVTLECHISG-YPSPTVTWYREDYQIESSI---DFQITFQSGIA 952

Query: 75   ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTF 134
             L I +A   DSG + C  +++ G  S S  + +  S      TT  +   K   +EK F
Sbjct: 953  RLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE--KFTTEEKRF 1010



 Score = 38.9 bits (89), Expect = 0.013
 Identities = 25/79 (31%), Positives = 39/79 (49%), Gaps = 6/79 (7%)

Query: 49    WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT- 107
             W K+G  + +  K    K+ +  G   L I+K   +DSG Y C V +  G+ S+S  +T 
Sbjct: 26513 WTKDGKAITQGGK---YKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 26569

Query: 108   --IVESNATSTSTTGTSHL 124
               I ++ A   ST  TS +
Sbjct: 26570 KAIKDTEAQKVSTQKTSEI 26588



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 28/81 (34%), Positives = 38/81 (46%), Gaps = 9/81 (11%)

Query: 36   CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 95
            CE S E  + + KWFK+G E+ +  K     I  K     L INK  L D  EY C+V +
Sbjct: 6023 CELSRE--NAKVKWFKDGAEIKKGKK---YDIISKGAVRILVINKCLLDDEAEYSCEVRT 6077

Query: 96   KLGNDSASANITIVESNATST 116
                   S  +T++E  A  T
Sbjct: 6078 A----RTSGMLTVLEEEAVFT 6094



 Score = 37.7 bits (86), Expect = 0.030
 Identities = 18/70 (25%), Positives = 31/70 (44%)

Query: 49    WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
             W+K+G ++   +  +    +   G  +L IN  +  D  EY     +K G DS  A +T+
Sbjct: 25351 WYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 25410

Query: 109   VESNATSTST 118
                   + ST
Sbjct: 25411 TLHPPPTDST 25420



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 26/92 (28%), Positives = 43/92 (46%), Gaps = 8/92 (8%)

Query: 15    PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFK---WFKNGNELNRKNKPQNIKIQKKP 71
             PP++ +    E+   SK + +     E S LR K   W+K+G +L      Q        
Sbjct: 26345 PPKITQFLKAEA---SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH--YSAD 26399

Query: 72    GKSELRINKASLADSGEYMCKVISKLGNDSAS 103
             G  EL+IN  + +D GEY+C++  + G    +
Sbjct: 26400 GTYELKINNLTESDQGEYVCEISGEGGTSKTN 26431



 Score = 35.4 bits (80), Expect = 0.15
 Identities = 27/111 (24%), Positives = 42/111 (37%), Gaps = 3/111 (2%)

Query: 8    RVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 67
            ++G    P  LKE+K    A G   +       E +     WFK   +L          I
Sbjct: 3693 KLGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPT-VTWFKENKQLC--TSVYYTII 3749

Query: 68   QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST 118
                G     +N     DSG Y+CK  + LG  + +A + ++  +   T T
Sbjct: 3750 HNPNGSGTFIVNDPQREDSGLYICKAENMLGESTCAAELLVLLEDTDMTDT 3800



 Score = 35.4 bits (80), Expect = 0.15
 Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 2/43 (4%)

Query: 19   KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNK 61
            K ++ Q    G+  VL CE S E  + + KWFKNG E+ +  K
Sbjct: 5917 KPLEDQTVEEGATAVLECEVSRE--NAKVKWFKNGTEILKSKK 5957



 Score = 33.9 bits (76), Expect = 0.43
 Identities = 29/103 (28%), Positives = 43/103 (41%), Gaps = 7/103 (6%)

Query: 19   KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 78
            K +  Q  A   + V  CE ++  S  + +W ++G  L   N   NI+ +    K  L I
Sbjct: 2578 KPLTDQTVAESQEAVFECEVANPDS--KGEWLRDGKHLPLTN---NIRSESDGHKRRLII 2632

Query: 79   NKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGT 121
                L D GEY  KV +     SA   +  V+   T  + T T
Sbjct: 2633 AATKLDDIGEYTYKVAT--SKTSAKLKVEAVKIKKTLKNLTVT 2673



 Score = 33.9 bits (76), Expect = 0.43
 Identities = 21/101 (20%), Positives = 42/101 (41%), Gaps = 3/101 (2%)

Query: 8     RVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 67
             +V +  + P   ++       G  +   C+  +   S +  W+    +L    K    +I
Sbjct: 25189 KVASIEIGPVSGQIMHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEK---YEI 25245

Query: 68    QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
               + G + L +   +  D G Y CKV++  G DS+ A + +
Sbjct: 25246 TYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFV 25286



 Score = 33.5 bits (75), Expect = 0.56
 Identities = 26/97 (26%), Positives = 43/97 (44%), Gaps = 2/97 (2%)

Query: 10   GTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK 69
            G  A P  + +   Q+   G  +V  C+         + W K+G  L    +   +   K
Sbjct: 1031 GEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVY-WKKSGVPLTTGYR-YKVSYNK 1088

Query: 70   KPGKSELRINKASLADSGEYMCKVISKLGNDSASANI 106
            + G+ +L I+     D+GEY   V +K G  SASA++
Sbjct: 1089 QTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1125



 Score = 33.1 bits (74), Expect = 0.73
 Identities = 26/101 (25%), Positives = 41/101 (40%), Gaps = 25/101 (24%)

Query: 18   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
            LK++ ++E     K  +  E +  Y  + +KW KNG E+   +K Q   ++ K     L 
Sbjct: 2929 LKDINAEE-----KDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQ---MRTKKLTHSLN 2980

Query: 78   INKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST 118
            I      D+ +Y                 T V   ATST+T
Sbjct: 2981 IRNVHFGDAADY-----------------TFVAGKATSTAT 3004



 Score = 33.1 bits (74), Expect = 0.73
 Identities = 26/96 (27%), Positives = 44/96 (45%), Gaps = 11/96 (11%)

Query: 18   LKEMK----SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 73
            +KE+K    ++    GS  +  C  S   S+    W K+G+ +    K + I   K    
Sbjct: 4746 VKEIKDIILTESEFVGSSAIFECLVSP--STAITTWMKDGSNIRESPKHRFIADGKD--- 4800

Query: 74   SELRINKASLADSGEYMCKVISKLGNDSASANITIV 109
             +L I    L+D+GEY C  + +LGN   ++   +V
Sbjct: 4801 RKLHIIDVQLSDAGEYTC--VLRLGNKEKTSTAKLV 4834



 Score = 32.7 bits (73), Expect = 0.96
 Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 5/76 (6%)

Query: 18   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
            ++ ++ Q        V  C+ S E +++  KW++NG E+    K    K +K      L 
Sbjct: 6454 VEHLEDQTVTEFDDAVFSCQLSREKANV--KWYRNGREIKEGKK---YKFEKDGSIHRLI 6508

Query: 78   INKASLADSGEYMCKV 93
            I    L D  EY C V
Sbjct: 6509 IKDCRLDDECEYACGV 6524



 Score = 32.7 bits (73), Expect = 0.96
 Identities = 16/61 (26%), Positives = 34/61 (55%), Gaps = 3/61 (4%)

Query: 49   WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
            W K+G E+   ++   + ++     + L + K+  AD+G Y   + +KLG+ +AS N+ +
Sbjct: 8048 WHKDGKEVKASDR---LTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKV 8104

Query: 109  V 109
            +
Sbjct: 8105 I 8105



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 26/117 (22%), Positives = 42/117 (35%), Gaps = 4/117 (3%)

Query: 3     KGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKP 62
             K    ++ TT     L + +S     G      C+T  E       W + G  L+   + 
Sbjct: 26177 KSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPT-VTWLRKGQVLSTSARH 26235

Query: 63    QNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTT 119
             Q   +     KS   I+    +D G Y   V +  G   A   +TI ++  T  + T
Sbjct: 26236 Q---VTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVT 26289



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 24/102 (23%), Positives = 46/102 (45%), Gaps = 3/102 (2%)

Query: 8     RVGTTALPPRLKEMKSQESA-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIK 66
             + G   +PP+++ + S  S   G  L + C  + E +     W   G +++ + + +   
Sbjct: 26949 KAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTP-EVTWSCGGRKIHSQEQGR-FH 27006

Query: 67    IQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
             I+     + L I      D G Y   + ++ G+DSA+ NI I
Sbjct: 27007 IENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 27048



 Score = 31.2 bits (69), Expect = 2.8
 Identities = 27/93 (29%), Positives = 42/93 (45%), Gaps = 8/93 (8%)

Query: 18   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
            LK+ + +E     ++V  CE ++E    + KWF+N   +   +K     I +K     LR
Sbjct: 6274 LKDTRVKEQ---QEVVFNCEVNTE--GAKAKWFRNEEAIFDSSK---YIILQKDLVYTLR 6325

Query: 78   INKASLADSGEYMCKVISKLGNDSASANITIVE 110
            I  A L D   Y   + +  G +  SA   IVE
Sbjct: 6326 IRDAHLDDQANYNVSLTNHRGENVKSAANLIVE 6358



 Score = 30.8 bits (68), Expect = 3.6
 Identities = 25/101 (24%), Positives = 44/101 (43%), Gaps = 7/101 (6%)

Query: 11    TTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNI-KIQK 69
             T  L P +K+  + +  AG  +VL   +       +  W K G ++    +P +I +I  
Sbjct: 14005 TIVLDPTIKDGLTIK--AGDTIVLNAISILGKPLPKSSWSKAGKDI----RPSDITQITS 14058

Query: 70    KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
              P  S L I  A+  D+GEY     +  G       +T+++
Sbjct: 14059 TPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLD 14099



 Score = 29.6 bits (65), Expect = 8.1
 Identities = 14/62 (22%), Positives = 31/62 (50%), Gaps = 1/62 (1%)

Query: 49    WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
             W K+ +  +    P+ +KI  +   S+  + KA  +D G+Y+    +  G+  A A + +
Sbjct: 11863 WTKDKDATDLTRSPR-VKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNV 11921

Query: 109   VE 110
             ++
Sbjct: 11922 LD 11923


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.125    0.360 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,570,152
Number of Sequences: 37866
Number of extensions: 1214725
Number of successful extensions: 7596
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 114
Number of HSP's successfully gapped in prelim test: 438
Number of HSP's that attempted gapping in prelim test: 5797
Number of HSP's gapped (non-prelim): 2085
length of query: 590
length of database: 18,247,518
effective HSP length: 108
effective length of query: 482
effective length of database: 14,157,990
effective search space: 6824151180
effective search space used: 6824151180
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.