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Search of human proteins with 236462348
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens]
(624 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens] 1252 0.0
gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens] 1228 0.0
gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens] 1209 0.0
gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens] 1204 0.0
gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens] 1171 0.0
gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens] 1171 0.0
gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens] 776 0.0
gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens] 775 0.0
gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens] 743 0.0
gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens] 485 e-137
gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens] 396 e-110
gi|7669532 neuregulin 2 isoform 4 [Homo sapiens] 383 e-106
gi|7669530 neuregulin 2 isoform 3 [Homo sapiens] 369 e-102
gi|7669528 neuregulin 2 isoform 2 [Homo sapiens] 365 e-101
gi|4758832 neuregulin 2 isoform 1 [Homo sapiens] 356 4e-98
gi|116006965 neuregulin 1 isoform HRG-gamma [Homo sapiens] 353 3e-97
gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens] 315 8e-86
gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens] 315 8e-86
gi|236462984 neuregulin 1 isoform HRG-gamma2 [Homo sapiens] 310 2e-84
gi|236464356 neuregulin 1 isoform HRG-gamma3 [Homo sapiens] 272 8e-73
gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens] 139 8e-33
gi|66730481 neuregulin 3 [Homo sapiens] 112 1e-24
gi|110349719 titin isoform N2-A [Homo sapiens] 56 9e-08
gi|110349717 titin isoform novex-2 [Homo sapiens] 56 9e-08
gi|110349713 titin isoform novex-1 [Homo sapiens] 56 9e-08
gi|110349715 titin isoform N2-B [Homo sapiens] 56 9e-08
gi|221316757 neurotrimin isoform 3 [Homo sapiens] 52 2e-06
gi|45594240 limbic system-associated membrane protein [Homo sapi... 52 2e-06
gi|221316762 neurotrimin isoform 4 [Homo sapiens] 51 3e-06
gi|115298665 neurotrimin isoform 2 [Homo sapiens] 51 3e-06
>gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens]
Length = 624
Score = 1252 bits (3240), Expect = 0.0
Identities = 624/624 (100%), Positives = 624/624 (100%)
Query: 1 MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN
Sbjct: 1 MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
Query: 61 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 120
KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA
Sbjct: 61 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 120
Query: 121 STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 180
STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD
Sbjct: 121 STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 180
Query: 181 LSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVV 240
LSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVV
Sbjct: 181 LSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVV 240
Query: 241 GIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKN 300
GIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKN
Sbjct: 241 GIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKN 300
Query: 301 VISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSV 360
VISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSV
Sbjct: 301 VISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSV 360
Query: 361 ENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSP 420
ENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSP
Sbjct: 361 ENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSP 420
Query: 421 VDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQ 480
VDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQ
Sbjct: 421 VDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQ 480
Query: 481 QFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHI 540
QFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHI
Sbjct: 481 QFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHI 540
Query: 541 ANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAG 600
ANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAG
Sbjct: 541 ANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAG 600
Query: 601 RFSTQEEIQARLSSVIANQDPIAV 624
RFSTQEEIQARLSSVIANQDPIAV
Sbjct: 601 RFSTQEEIQARLSSVIANQDPIAV 624
>gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens]
Length = 645
Score = 1228 bits (3178), Expect = 0.0
Identities = 612/612 (100%), Positives = 612/612 (100%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 132
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP
Sbjct: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
Query: 133 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 192
IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP
Sbjct: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 213
Query: 193 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 252
NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK
Sbjct: 214 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 273
Query: 253 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 312
KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA
Sbjct: 274 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 333
Query: 313 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 372
ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP
Sbjct: 334 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 393
Query: 373 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP 432
RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP
Sbjct: 394 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP 453
Query: 433 PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD 492
PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD
Sbjct: 454 PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD 513
Query: 493 SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS 552
SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS
Sbjct: 514 SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS 573
Query: 553 QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL 612
QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL
Sbjct: 574 QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL 633
Query: 613 SSVIANQDPIAV 624
SSVIANQDPIAV
Sbjct: 634 SSVIANQDPIAV 645
>gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens]
Length = 607
Score = 1209 bits (3129), Expect = 0.0
Identities = 606/624 (97%), Positives = 607/624 (97%), Gaps = 17/624 (2%)
Query: 1 MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN
Sbjct: 1 MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
Query: 61 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 120
KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA
Sbjct: 61 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 120
Query: 121 STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 180
STEGAYVSS +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD
Sbjct: 121 STEGAYVSS-----------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 163
Query: 181 LSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVV 240
LSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVV
Sbjct: 164 LSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVV 223
Query: 241 GIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKN 300
GIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKN
Sbjct: 224 GIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKN 283
Query: 301 VISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSV 360
VISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSV
Sbjct: 284 VISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSV 343
Query: 361 ENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSP 420
ENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSP
Sbjct: 344 ENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSP 403
Query: 421 VDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQ 480
VDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQ
Sbjct: 404 VDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQ 463
Query: 481 QFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHI 540
QFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHI
Sbjct: 464 QFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHI 523
Query: 541 ANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAG 600
ANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAG
Sbjct: 524 ANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAG 583
Query: 601 RFSTQEEIQARLSSVIANQDPIAV 624
RFSTQEEIQARLSSVIANQDPIAV
Sbjct: 584 RFSTQEEIQARLSSVIANQDPIAV 607
>gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens]
Length = 637
Score = 1204 bits (3116), Expect = 0.0
Identities = 604/612 (98%), Positives = 604/612 (98%), Gaps = 8/612 (1%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 132
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP
Sbjct: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
Query: 133 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 192
IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP
Sbjct: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 213
Query: 193 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 252
NEFTGDRCQNYVMASFYK AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK
Sbjct: 214 NEFTGDRCQNYVMASFYK--------AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 265
Query: 253 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 312
KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA
Sbjct: 266 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 325
Query: 313 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 372
ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP
Sbjct: 326 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 385
Query: 373 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP 432
RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP
Sbjct: 386 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP 445
Query: 433 PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD 492
PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD
Sbjct: 446 PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD 505
Query: 493 SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS 552
SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS
Sbjct: 506 SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS 565
Query: 553 QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL 612
QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL
Sbjct: 566 QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL 625
Query: 613 SSVIANQDPIAV 624
SSVIANQDPIAV
Sbjct: 626 SSVIANQDPIAV 637
>gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens]
Length = 640
Score = 1171 bits (3030), Expect = 0.0
Identities = 591/612 (96%), Positives = 592/612 (96%), Gaps = 5/612 (0%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 132
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP
Sbjct: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
Query: 133 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 192
IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC
Sbjct: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQ 213
Query: 193 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 252
FTG RC V +AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK
Sbjct: 214 PGFTGARCTENVPMKVQNQ-----EKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 268
Query: 253 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 312
KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA
Sbjct: 269 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 328
Query: 313 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 372
ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP
Sbjct: 329 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 388
Query: 373 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP 432
RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP
Sbjct: 389 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP 448
Query: 433 PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD 492
PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD
Sbjct: 449 PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD 508
Query: 493 SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS 552
SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS
Sbjct: 509 SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS 568
Query: 553 QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL 612
QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL
Sbjct: 569 QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL 628
Query: 613 SSVIANQDPIAV 624
SSVIANQDPIAV
Sbjct: 629 SSVIANQDPIAV 640
>gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens]
Length = 590
Score = 1171 bits (3029), Expect = 0.0
Identities = 589/624 (94%), Positives = 590/624 (94%), Gaps = 34/624 (5%)
Query: 1 MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN
Sbjct: 1 MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
Query: 61 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 120
KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN
Sbjct: 61 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------- 112
Query: 121 STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 180
+TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD
Sbjct: 113 --------------------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 146
Query: 181 LSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVV 240
LSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVV
Sbjct: 147 LSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVV 206
Query: 241 GIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKN 300
GIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKN
Sbjct: 207 GIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKN 266
Query: 301 VISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSV 360
VISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSV
Sbjct: 267 VISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSV 326
Query: 361 ENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSP 420
ENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSP
Sbjct: 327 ENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSP 386
Query: 421 VDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQ 480
VDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQ
Sbjct: 387 VDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQ 446
Query: 481 QFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHI 540
QFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHI
Sbjct: 447 QFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHI 506
Query: 541 ANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAG 600
ANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAG
Sbjct: 507 ANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAG 566
Query: 601 RFSTQEEIQARLSSVIANQDPIAV 624
RFSTQEEIQARLSSVIANQDPIAV
Sbjct: 567 RFSTQEEIQARLSSVIANQDPIAV 590
>gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens]
Length = 459
Score = 776 bits (2004), Expect = 0.0
Identities = 387/396 (97%), Positives = 388/396 (97%), Gaps = 8/396 (2%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 132
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP
Sbjct: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
Query: 133 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 192
IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP
Sbjct: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 213
Query: 193 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 252
NEFTGDRCQNYVMASFYK AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK
Sbjct: 214 NEFTGDRCQNYVMASFYK--------AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 265
Query: 253 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 312
KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA
Sbjct: 266 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 325
Query: 313 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 372
ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP
Sbjct: 326 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 385
Query: 373 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERY 408
RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSER+
Sbjct: 386 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERH 421
>gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens]
Length = 420
Score = 775 bits (2002), Expect = 0.0
Identities = 387/395 (97%), Positives = 387/395 (97%), Gaps = 8/395 (2%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 132
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP
Sbjct: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
Query: 133 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 192
IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP
Sbjct: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 213
Query: 193 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 252
NEFTGDRCQNYVMASFYK AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK
Sbjct: 214 NEFTGDRCQNYVMASFYK--------AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 265
Query: 253 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 312
KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA
Sbjct: 266 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 325
Query: 313 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 372
ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP
Sbjct: 326 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 385
Query: 373 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSER 407
RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSER
Sbjct: 386 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSER 420
>gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens]
Length = 462
Score = 743 bits (1918), Expect = 0.0
Identities = 374/396 (94%), Positives = 376/396 (94%), Gaps = 5/396 (1%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 132
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP
Sbjct: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
Query: 133 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 192
IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC
Sbjct: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQ 213
Query: 193 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 252
FTG RC V +AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK
Sbjct: 214 PGFTGARCTENVPMKVQNQ-----EKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 268
Query: 253 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 312
KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA
Sbjct: 269 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 328
Query: 313 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 372
ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP
Sbjct: 329 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 388
Query: 373 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERY 408
RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSER+
Sbjct: 389 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERH 424
>gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens]
Length = 308
Score = 485 bits (1248), Expect = e-137
Identities = 239/263 (90%), Positives = 243/263 (92%), Gaps = 5/263 (1%)
Query: 146 SSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVM 205
++TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC FTG RC V
Sbjct: 13 TATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP 72
Query: 206 ASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS 265
+AEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS
Sbjct: 73 MKVQNQ-----EKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS 127
Query: 266 LRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTA 325
LRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTA
Sbjct: 128 LRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTA 187
Query: 326 HHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPREC 385
HHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPREC
Sbjct: 188 HHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPREC 247
Query: 386 NSFLRHARETPDSYRDSPHSERY 408
NSFLRHARETPDSYRDSPHSER+
Sbjct: 248 NSFLRHARETPDSYRDSPHSERH 270
>gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens]
Length = 241
Score = 396 bits (1018), Expect = e-110
Identities = 197/197 (100%), Positives = 197/197 (100%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 132
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP
Sbjct: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
Query: 133 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 192
IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP
Sbjct: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 213
Query: 193 NEFTGDRCQNYVMASFY 209
NEFTGDRCQNYVMASFY
Sbjct: 214 NEFTGDRCQNYVMASFY 230
>gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]
Length = 852
Score = 383 bits (983), Expect = e-106
Identities = 250/647 (38%), Positives = 353/647 (54%), Gaps = 99/647 (15%)
Query: 3 KGRAGRVGTT--ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
K G++ T A P+LK+MKSQ G K L+CE ++ ++WFK+G ELNR
Sbjct: 222 KKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRS- 280
Query: 61 KPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGM 118
++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ + +
Sbjct: 281 --RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYV---------- 328
Query: 119 PASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMV 178
N+ S+T +S +G H KC E K++CVNGG C+ +
Sbjct: 329 ------------------------NSVSTTLSSWSG--HARKCNETAKSYCVNGGVCYYI 362
Query: 179 KDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALL 238
+ ++ S CKCP +TGDRCQ + M +F KHLG E EAEELYQKRVLTITGIC+ALL
Sbjct: 363 EGINQLS---CKCPVGYTGDRCQQFAMVNFSKHLGFELKEAEELYQKRVLTITGICVALL 419
Query: 239 VVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVS 298
VVGI+CVVAYCKTKKQRK++H+ LRQ++ N ++ANGP HP PE +Q+ + Y+S
Sbjct: 420 VVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPSHPRLDPEEIQMAD-YIS 477
Query: 299 KNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PSHSWSNGHTESILSESHS 353
KNV +++H++ RE ET+FS SH S +HH +T T T SH+WS +ES+ S+S S
Sbjct: 478 KNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQS 537
Query: 354 VIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYV 409
I++SSV S+ +SP R R + H ++ DS RDSPHSERYV
Sbjct: 538 GIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH--DSVDSLRDSPHSERYV 595
Query: 410 SAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMA-VSPFMEEERPLLLVTPP 468
SA+TTPAR+SPVDFH + + P E++ P S+ VS+P A +S + E++PLL P
Sbjct: 596 SALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAP 655
Query: 469 RLREKKFDHHP-------QQFSSFHHNPAHDS------------NSLPASPLRIVEDEEY 509
P + + S+++ A SLPASP RI ED+EY
Sbjct: 656 PGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEY 715
Query: 510 ETTQEYEPAQEPVKKL--------ANSRRAKRTKPNGHIANR-------LEVDSNTSSQS 554
ETTQE P P + A RR +R++ NG A R L + S + S
Sbjct: 716 ETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGS 775
Query: 555 SNSESETEDERVG----EDTPFLGIQNPL-AASLEATPAFRLADSRT 596
+++ + D+ G E TPFLG++ A ++ P ADSRT
Sbjct: 776 ASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRT 822
>gi|7669530 neuregulin 2 isoform 3 [Homo sapiens]
Length = 858
Score = 369 bits (947), Expect = e-102
Identities = 248/653 (37%), Positives = 349/653 (53%), Gaps = 105/653 (16%)
Query: 3 KGRAGRVGTT--ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
K G++ T A P+LK+MKSQ G K L+CE ++ ++WFK+G ELNR
Sbjct: 222 KKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRS- 280
Query: 61 KPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGM 118
++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ + +
Sbjct: 281 --RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYV---------- 328
Query: 119 PASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMV 178
N+ S+T +S +G H KC E K++CVNGG C+ +
Sbjct: 329 ------------------------NSVSTTLSSWSG--HARKCNETAKSYCVNGGVCYYI 362
Query: 179 KDLSNPSRYLCKCPNEFTGDRCQNYVMASFY------KHLGIEFMEAEELYQKRVLTITG 232
+ ++ S CKCPN F G RC + Y KHLG E EAEELYQKRVLTITG
Sbjct: 363 EGINQLS---CKCPNGFFGQRCLEKLPLRLYMPDPKQKHLGFELKEAEELYQKRVLTITG 419
Query: 233 ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQL 292
IC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++ N ++ANGP HP PE +Q+
Sbjct: 420 ICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPSHPRLDPEEIQM 478
Query: 293 VNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PSHSWSNGHTESI 347
+ Y+SKNV +++H++ RE ET+FS SH S +HH +T T T SH+WS +ES+
Sbjct: 479 AD-YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESL 537
Query: 348 LSESHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSP 403
S+S S I++SSV S+ +SP R R + H ++ DS RDSP
Sbjct: 538 TSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH--DSVDSLRDSP 595
Query: 404 HSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMA-VSPFMEEERPL 462
HSERYVSA+TTPAR+SPVDFH + + P E++ P S+ VS+P A +S + E++PL
Sbjct: 596 HSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPL 655
Query: 463 LLVTPPRLREKKFDHHP-------QQFSSFHHNPAHDS------------NSLPASPLRI 503
L P P + + S+++ A SLPASP RI
Sbjct: 656 LRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRI 715
Query: 504 VEDEEYETTQEYEPAQEPVKKL--------ANSRRAKRTKPNGHIANR-------LEVDS 548
ED+EYETTQE P P + A RR +R++ NG A R L + S
Sbjct: 716 PEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSS 775
Query: 549 NTSSQSSNSESETEDERVG----EDTPFLGIQNPL-AASLEATPAFRLADSRT 596
+ S+++ + D+ G E TPFLG++ A ++ P ADSRT
Sbjct: 776 GSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRT 828
>gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]
Length = 844
Score = 365 bits (937), Expect = e-101
Identities = 245/647 (37%), Positives = 348/647 (53%), Gaps = 107/647 (16%)
Query: 3 KGRAGRVGTT--ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
K G++ T A P+LK+MKSQ G K L+CE ++ ++WFK+G ELNR
Sbjct: 222 KKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRS- 280
Query: 61 KPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGM 118
++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ + +
Sbjct: 281 --RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYV---------- 328
Query: 119 PASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMV 178
N+ S+T +S +G H KC E K++CVNGG C+ +
Sbjct: 329 ------------------------NSVSTTLSSWSG--HARKCNETAKSYCVNGGVCYYI 362
Query: 179 KDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALL 238
+ ++ S CKCP +TGDRCQ + M +F K AEELYQKRVLTITGIC+ALL
Sbjct: 363 EGINQLS---CKCPVGYTGDRCQQFAMVNFSK--------AEELYQKRVLTITGICVALL 411
Query: 239 VVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVS 298
VVGI+CVVAYCKTKKQRK++H+ LRQ++ N ++ANGP HP PE +Q+ + Y+S
Sbjct: 412 VVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPSHPRLDPEEIQMAD-YIS 469
Query: 299 KNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PSHSWSNGHTESILSESHS 353
KNV +++H++ RE ET+FS SH S +HH +T T T SH+WS +ES+ S+S S
Sbjct: 470 KNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQS 529
Query: 354 VIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYV 409
I++SSV S+ +SP R R + H ++ DS RDSPHSERYV
Sbjct: 530 GIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH--DSVDSLRDSPHSERYV 587
Query: 410 SAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMA-VSPFMEEERPLLLVTPP 468
SA+TTPAR+SPVDFH + + P E++ P S+ VS+P A +S + E++PLL P
Sbjct: 588 SALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAP 647
Query: 469 RLREKKFDHHP-------QQFSSFHHNPAHDS------------NSLPASPLRIVEDEEY 509
P + + S+++ A SLPASP RI ED+EY
Sbjct: 648 PGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEY 707
Query: 510 ETTQEYEPAQEPVKKL--------ANSRRAKRTKPNGHIANR-------LEVDSNTSSQS 554
ETTQE P P + A RR +R++ NG A R L + S + S
Sbjct: 708 ETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGS 767
Query: 555 SNSESETEDERVG----EDTPFLGIQNPL-AASLEATPAFRLADSRT 596
+++ + D+ G E TPFLG++ A ++ P ADSRT
Sbjct: 768 ASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRT 814
>gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]
Length = 850
Score = 356 bits (913), Expect = 4e-98
Identities = 242/647 (37%), Positives = 345/647 (53%), Gaps = 101/647 (15%)
Query: 3 KGRAGRVGTT--ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
K G++ T A P+LK+MKSQ G K L+CE ++ ++WFK+G ELNR
Sbjct: 222 KKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRS- 280
Query: 61 KPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGM 118
++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ + +
Sbjct: 281 --RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYV---------- 328
Query: 119 PASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMV 178
N+ S+T +S +G H KC E K++CVNGG C+ +
Sbjct: 329 ------------------------NSVSTTLSSWSG--HARKCNETAKSYCVNGGVCYYI 362
Query: 179 KDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALL 238
+ ++ S CKCPN F G RC + Y + +AEELYQKRVLTITGIC+ALL
Sbjct: 363 EGINQLS---CKCPNGFFGQRCLEKLPLRLY--MPDPKQKAEELYQKRVLTITGICVALL 417
Query: 239 VVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVS 298
VVGI+CVVAYCKTKKQRK++H+ LRQ++ N ++ANGP HP PE +Q+ + Y+S
Sbjct: 418 VVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPSHPRLDPEEIQMAD-YIS 475
Query: 299 KNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PSHSWSNGHTESILSESHS 353
KNV +++H++ RE ET+FS SH S +HH +T T T SH+WS +ES+ S+S S
Sbjct: 476 KNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQS 535
Query: 354 VIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYV 409
I++SSV S+ +SP R R + H ++ DS RDSPHSERYV
Sbjct: 536 GIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH--DSVDSLRDSPHSERYV 593
Query: 410 SAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMA-VSPFMEEERPLLLVTPP 468
SA+TTPAR+SPVDFH + + P E++ P S+ VS+P A +S + E++PLL P
Sbjct: 594 SALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAP 653
Query: 469 RLREKKFDHHP-------QQFSSFHHNPAHDS------------NSLPASPLRIVEDEEY 509
P + + S+++ A SLPASP RI ED+EY
Sbjct: 654 PGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEY 713
Query: 510 ETTQEYEPAQEPVKKL--------ANSRRAKRTKPNGHIANR-------LEVDSNTSSQS 554
ETTQE P P + A RR +R++ NG A R L + S + S
Sbjct: 714 ETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGS 773
Query: 555 SNSESETEDERVG----EDTPFLGIQNPL-AASLEATPAFRLADSRT 596
+++ + D+ G E TPFLG++ A ++ P ADSRT
Sbjct: 774 ASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRT 820
>gi|116006965 neuregulin 1 isoform HRG-gamma [Homo sapiens]
Length = 211
Score = 353 bits (906), Expect = 3e-97
Identities = 178/178 (100%), Positives = 178/178 (100%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 132
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP
Sbjct: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
Query: 133 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 190
IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK
Sbjct: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 211
>gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens]
Length = 207
Score = 315 bits (807), Expect = 8e-86
Identities = 162/197 (82%), Positives = 163/197 (82%), Gaps = 34/197 (17%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 132
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN
Sbjct: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------------------- 133
Query: 133 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 192
+TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP
Sbjct: 134 --------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 179
Query: 193 NEFTGDRCQNYVMASFY 209
NEFTGDRCQNYVMASFY
Sbjct: 180 NEFTGDRCQNYVMASFY 196
>gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens]
Length = 422
Score = 315 bits (807), Expect = 8e-86
Identities = 162/197 (82%), Positives = 163/197 (82%), Gaps = 34/197 (17%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 249 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 308
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 132
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN
Sbjct: 309 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------------------- 348
Query: 133 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 192
+TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP
Sbjct: 349 --------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 394
Query: 193 NEFTGDRCQNYVMASFY 209
NEFTGDRCQNYVMASFY
Sbjct: 395 NEFTGDRCQNYVMASFY 411
>gi|236462984 neuregulin 1 isoform HRG-gamma2 [Homo sapiens]
Length = 194
Score = 310 bits (795), Expect = 2e-84
Identities = 160/178 (89%), Positives = 161/178 (90%), Gaps = 17/178 (9%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 132
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYV
Sbjct: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYV----- 148
Query: 133 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 190
SS+TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK
Sbjct: 149 ------------SSATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 194
>gi|236464356 neuregulin 1 isoform HRG-gamma3 [Homo sapiens]
Length = 177
Score = 272 bits (695), Expect = 8e-73
Identities = 143/178 (80%), Positives = 144/178 (80%), Gaps = 34/178 (19%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 132
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN
Sbjct: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------------------- 133
Query: 133 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 190
+TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK
Sbjct: 134 --------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 177
>gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens]
Length = 296
Score = 139 bits (350), Expect = 8e-33
Identities = 63/63 (100%), Positives = 63/63 (100%)
Query: 147 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA 206
STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA
Sbjct: 223 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA 282
Query: 207 SFY 209
SFY
Sbjct: 283 SFY 285
>gi|66730481 neuregulin 3 [Homo sapiens]
Length = 696
Score = 112 bits (280), Expect = 1e-24
Identities = 105/421 (24%), Positives = 188/421 (44%), Gaps = 40/421 (9%)
Query: 128 SSESPIRISVSTEGANTSSS-----TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLS 182
SS S S +T TS+S T+ ST + H C +K+ +C+N GECF+++ L+
Sbjct: 252 SSSSSSSSSATTTTPETSTSPKFHTTTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLT 311
Query: 183 NPSRYLCKCPNEFTGDRCQNY------VMASFYKHLGIEFMEAEELYQKRVLTITGICIA 236
++ C+C + G RC + +++ HLGIEFME+EE+YQ++VL+I+ I
Sbjct: 312 GSHKH-CRCKEGYQGVRCDQFLPKTDSILSDPTDHLGIEFMESEEVYQRQVLSISCIIFG 370
Query: 237 LLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVN-Q 295
+++VG+ C Y K+KKQ K++ ++L+ + ++ + N +VQL N
Sbjct: 371 IVIVGMFCAAFYFKSKKQAKQIQEQLKVPQNGKSYSLKASSTMAKSENLVKSHVQLQNYS 430
Query: 296 YVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSH-SWSNGHTESILSESHSV 354
V ++ +++ +E+ E+SF S +P S S H S+ S
Sbjct: 431 KVERHPVTA---LEKMMESSF-------VGPQSFPEVPSPDRGSQSVKHHRSLSSCCSPG 480
Query: 355 IVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTT 414
+ + PR RL G GP + E+ +D+ + Y S+
Sbjct: 481 QRSGMLHRNAFRRTPPSPRSRLGGIVGPA-----YQQLEESRIPDQDTIPCQGYSSSGLK 535
Query: 415 PARMSPVDFHTPSSPKSP---PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLR 471
R + ++ PS +P E V + S+ + P + E L + P +
Sbjct: 536 TQRNTSINMQLPSRETNPYFNSLEQKDLVGYSSTRASSVPIIPSVGLEETCLQM--PGIS 593
Query: 472 EKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRA 531
E K ++ ++ + S+P S I E +E + E QE ++ L ++RR+
Sbjct: 594 EVK----SIKWCKNSYSADVVNVSIPVSDCLIAEQQEVKIL--LETVQEQIRILTDARRS 647
Query: 532 K 532
+
Sbjct: 648 E 648
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 56.2 bits (134), Expect = 9e-08
Identities = 41/151 (27%), Positives = 76/151 (50%), Gaps = 13/151 (8%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
P + + +SQ G ++ CE S E S +WFKN ++ + N+ I +
Sbjct: 33134 PAFISQPRSQNINEGQNVLFTCEISGEPSP-EIEWFKNNLPISISS---NVSISRSRNVY 33189
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITIV-----ESNEII--TGMPASTEGAYV 127
L I AS++DSG+Y K + G SA+A++ ++ S E++ T S +G++
Sbjct: 33190 SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSF- 33248
Query: 128 SSESPIRISVSTEGANTSSSTSTSTTGTSHL 158
S +++S S + A+ SS +S+S + + +
Sbjct: 33249 -SSQSVQMSASKQEASFSSFSSSSASSMTEM 33278
Score = 53.5 bits (127), Expect = 6e-07
Identities = 56/227 (24%), Positives = 91/227 (40%), Gaps = 31/227 (13%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
A P ++++ E A G CE S ++RF+WFK G E+ +K I+
Sbjct: 3454 AAPVIKRKIEPLEVALGHLAKFTCEIQSA-PNVRFQWFKAGREIYESDK---CSIRSSKY 3509
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 132
S L I + + D GEY CK ++ G+ S +A +T+ E AY +
Sbjct: 3510 ISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTE--------------AYPPTFLS 3555
Query: 133 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKE-------KTFCVNGGECFMVKDLSN-- 183
S++T + T TGT + +K+ + ++ E + +LSN
Sbjct: 3556 RPKSLTTFVGKAAKFICT-VTGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLT 3614
Query: 184 ---PSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRV 227
Y CK N+F D CQ ++ H E + K+V
Sbjct: 3615 IQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSAINKKV 3661
Score = 49.3 bits (116), Expect = 1e-05
Identities = 54/242 (22%), Positives = 95/242 (39%), Gaps = 30/242 (12%)
Query: 3 KGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKP 62
K +G + P + + S++ GS + L+ T + L +WFK EL
Sbjct: 4194 KDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLK-STFQGSTPLTIRWFKGNKELVSGG-- 4250
Query: 63 QNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI---------VESNE 113
+ I K+ +S L + +DSG Y CKV + G SAN+ + +E ++
Sbjct: 4251 -SCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQ 4309
Query: 114 IITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGG 173
++ A+ V+ PI+I T AN +K + K + V
Sbjct: 4310 LLKKGDATQLACKVTGTPPIKI---TWFANDRE------------IKESSKHRMSFVEST 4354
Query: 174 ECFMVKD--LSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTIT 231
+ D + + Y+C+ NE D C + V+ + EF E L + V+ +
Sbjct: 4355 AVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLA 4414
Query: 232 GI 233
+
Sbjct: 4415 EV 4416
Score = 48.9 bits (115), Expect = 1e-05
Identities = 49/189 (25%), Positives = 84/189 (44%), Gaps = 13/189 (6%)
Query: 15 PPR-LKEMKSQESAA-GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
PP+ +K++++ + A G + L C+ S ++ WF+N +EL+ K I
Sbjct: 6363 PPKFVKKLEASKVAKQGESIQLECKISGS-PEIKVSWFRNDSELHESWKYNMSFINSV-- 6419
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 132
+ L IN+AS DSG+Y+C+ + +G+ S S +T V++ + T P S GA S+
Sbjct: 6420 -ALLTINEASAEDSGDYICEAHNGVGDASCSTALT-VKAPPVFTQKP-SPVGALKGSDVI 6476
Query: 133 IRISVS-TEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC 191
++ +S T S K K ++ + + S+ Y CK
Sbjct: 6477 LQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLH----ILNLEASDVGEYHCKA 6532
Query: 192 PNEFTGDRC 200
NE D C
Sbjct: 6533 TNEVGSDTC 6541
Score = 48.5 bits (114), Expect = 2e-05
Identities = 49/209 (23%), Positives = 85/209 (40%), Gaps = 37/209 (17%)
Query: 8 RVGTTALPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIK 66
R+ LPP +++K E G + L C + + ++ W+++G L +N++
Sbjct: 6167 RIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGS-APIQVCWYRDGVLLR---DDENLQ 6222
Query: 67 IQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE------------SNEI 114
+ L+I + L+ SG+Y C + LG S+SA +T E S ++
Sbjct: 6223 TSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSIDV 6282
Query: 115 ITGMPASTEGAYVSSESPIRISVSTEGANT---SSSTSTSTTGTSHLVKCAEKEKTFCVN 171
I G A E +V+ P+RI+ S + + T T T HL + V
Sbjct: 6283 IAGESADFE-CHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHL-------RILKVG 6334
Query: 172 GGECFMVKDLSNPSRYLCKCPNEFTGDRC 200
G+ +Y C+ N+ D C
Sbjct: 6335 KGD---------SGQYTCQATNDVGKDMC 6354
Score = 47.8 bits (112), Expect = 3e-05
Identities = 28/104 (26%), Positives = 51/104 (49%), Gaps = 5/104 (4%)
Query: 8 RVGTTALPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIK 66
RV +PP K++ + GS + + C+ S + +WFK+G E++ K + +
Sbjct: 5229 RVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLP-ISAQWFKDGKEISTSAKYRLVC 5287
Query: 67 IQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
++ L +N L D+ Y CKV + G+D+ S +T+ E
Sbjct: 5288 HERSVS---LEVNNLELEDTANYTCKVSNVAGDDACSGILTVKE 5328
Score = 47.8 bits (112), Expect = 3e-05
Identities = 56/219 (25%), Positives = 83/219 (37%), Gaps = 32/219 (14%)
Query: 8 RVGTTALPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIK 66
+V +PP +++K +GS +V+ C+ + WF GNE++ K Q
Sbjct: 7674 QVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGS-PPISVSWFHEGNEISSGRKYQTTL 7732
Query: 67 IQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAY 126
L +N +DSG+Y C + G+D SA +T+ E P S +
Sbjct: 7733 TDNT---CALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVRE--------PPS----F 7777
Query: 127 VSSESPIRISVSTEGANTSSSTSTST------TGTSHLV---KCAEKEKTFCVNGGECFM 177
V P+ + T TS T G+S LV +C + V E F
Sbjct: 7778 VQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLED-SVAELELFD 7836
Query: 178 VKDLSNPSRYLCKCPNEFTGDRCQNYVM----ASFYKHL 212
V D S Y C NE C ++ A F K L
Sbjct: 7837 V-DTSQSGEYTCIVSNEAGKASCTTHLYIKAPAKFVKRL 7874
Score = 46.6 bits (109), Expect = 7e-05
Identities = 27/98 (27%), Positives = 48/98 (48%), Gaps = 5/98 (5%)
Query: 14 LPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
+PP K++K +S GS + L C + + + +WFK+ E++ K K
Sbjct: 4673 IPPSFTKKLKKMDSIKGSFIDLECIVAGSHP-ISIQWFKDDQEISASEK---YKFSFHDN 4728
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
+ L I++ DSG Y C +K G++ S ++T+ E
Sbjct: 4729 TAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKE 4766
Score = 45.8 bits (107), Expect = 1e-04
Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 4/96 (4%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
P +KE++ +SA K+ L C+ + + W K+G +L ++ KI + +
Sbjct: 3644 PHFIKELEPVQSAINKKVHLECQVDED-RKVTVTWSKDGQKLP---PGKDYKICFEDKIA 3699
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
L I A L DSG Y+C ++ G+ S SA +T+ E
Sbjct: 3700 TLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVRE 3735
Score = 45.8 bits (107), Expect = 1e-04
Identities = 42/195 (21%), Positives = 75/195 (38%), Gaps = 17/195 (8%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
P ++E+K E S + L CE + W KN E+ K + +
Sbjct: 4955 PTFIRELKPVEVVKYSDVELECEVTGT-PPFEVTWLKNNREIRSSKK---YTLTDRVSVF 5010
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIR 134
L I K +D+GEY C V ++ G+ S S + + E I + + + +
Sbjct: 5011 NLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFI---------KKIENTTTVL 5061
Query: 135 ISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFC--VNGGECFMVKDLSN--PSRYLCK 190
S +T + + S S T E + + V+ ++ + N RY C+
Sbjct: 5062 KSSATFQSTVAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQ 5121
Query: 191 CPNEFTGDRCQNYVM 205
NE +RC +++
Sbjct: 5122 AKNESGVERCYAFLL 5136
Score = 45.4 bits (106), Expect = 2e-04
Identities = 34/108 (31%), Positives = 50/108 (46%), Gaps = 11/108 (10%)
Query: 31 KLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM 90
++ L+CE S + + KWFK+G E+ K I+ + L+I KA L D GEY+
Sbjct: 11679 EITLKCEVSKD---VPVKWFKDGEEIVPSPK---YSIKADGLRRILKIKKADLKDKGEYV 11732
Query: 91 CKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVS 138
C G D AN+T VE+ I P +V + I +S
Sbjct: 11733 C----DCGTDKTKANVT-VEARLIKVEKPLYGVEVFVGETAHFEIELS 11775
Score = 45.1 bits (105), Expect = 2e-04
Identities = 44/194 (22%), Positives = 79/194 (40%), Gaps = 33/194 (17%)
Query: 19 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 78
K +++ +S L C+ + +R WFK+G E+ ++ +I G + L I
Sbjct: 4117 KPLRNVDSVVNGTCRLDCKIAGSLP-MRVSWFKDGKEIAASDR---YRIAFVEGTASLEI 4172
Query: 79 NKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVS 138
+ + D+G + C+ + +G+ +S + + E +T P S + V S + + +
Sbjct: 4173 IRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVT-KPGSKD---VLPGSAVCLKST 4228
Query: 139 TEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD------------LSNPSR 186
+G ST T K KE V+GG C++ K+ S+
Sbjct: 4229 FQG---------STPLTIRWFK-GNKE---LVSGGSCYITKEALESSLELYLVKTSDSGT 4275
Query: 187 YLCKCPNEFTGDRC 200
Y CK N G C
Sbjct: 4276 YTCKVSNVAGGVEC 4289
Score = 45.1 bits (105), Expect = 2e-04
Identities = 53/194 (27%), Positives = 77/194 (39%), Gaps = 28/194 (14%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
+++ +S + G L C T + L KWFK+G EL NK + K G L+
Sbjct: 7589 VEKPESIKVTTGDTCTLEC-TVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSG---LK 7644
Query: 78 INKASLADSGEYMCKVISKLGNDSASANITIVESN--EIITGMPASTEGAYVSS------ 129
I + +DSG Y +V + +G DS +A++ + + T T G SS
Sbjct: 7645 IINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECK 7704
Query: 130 ---ESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSR 186
PI +S EG SS TT T + CA VN + + S+
Sbjct: 7705 VYGSPPISVSWFHEGNEISSGRKYQTTLTDN--TCA-----LTVN------MLEESDSGD 7751
Query: 187 YLCKCPNEFTGDRC 200
Y C N D C
Sbjct: 7752 YTCIATNMAGSDEC 7765
Score = 44.7 bits (104), Expect = 3e-04
Identities = 42/187 (22%), Positives = 75/187 (40%), Gaps = 13/187 (6%)
Query: 11 TTALPPRLKEMKSQESAA-GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK 69
T PP + S A GS ++L+CE S W K+ ++ K KI
Sbjct: 6453 TVKAPPVFTQKPSPVGALKGSDVILQCEISGT-PPFEVVWVKDRKQVRNSKK---FKITS 6508
Query: 70 KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS 129
K + L I +D GEY CK +++G+D+ S ++ E + + S +
Sbjct: 6509 KHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKL--SDTSTLIGD 6566
Query: 130 ESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMV--KDLSNPSRY 187
+R V EG S G +++ +E + ++ + + SN +Y
Sbjct: 6567 AVELRAIV--EGFQPISVVWLKDRG--EVIRESENTRISFIDNIATLQLGSPEASNSGKY 6622
Query: 188 LCKCPNE 194
+C+ N+
Sbjct: 6623 ICQIKND 6629
Score = 44.7 bits (104), Expect = 3e-04
Identities = 50/193 (25%), Positives = 78/193 (40%), Gaps = 26/193 (13%)
Query: 36 CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 95
CE S E + + KWFK+G E+ + K I K L INK L D EY C+V +
Sbjct: 12395 CELSRE--NAKVKWFKDGAEIKKGKK---YDIISKGAVRILVINKCLLDDEAEYSCEVRT 12449
Query: 96 KLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRI--SVSTEGANT---SSSTST 150
S +T++E + T A+ E VS I++ VS GA
Sbjct: 12450 A----RTSGMLTVLEEEAVFTKNLANIE---VSETDTIKLVCEVSKPGAEVIWYKGDEEI 12502
Query: 151 STTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY- 209
TG ++ K N L + Y C+ P+ T + + + +A+ +
Sbjct: 12503 IETGRYEILTEGRKRILVIQNA-------HLEDAGNYNCRLPSSRTDGKVKVHELAAEFI 12555
Query: 210 -KHLGIEFMEAEE 221
K +E +E E+
Sbjct: 12556 SKPQNLEILEGEK 12568
Score = 44.3 bits (103), Expect = 3e-04
Identities = 29/101 (28%), Positives = 47/101 (46%), Gaps = 13/101 (12%)
Query: 45 LRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASA 104
++ WFKN EL+ N +++ ++ L I + DSG Y C+ ++ +G+DS S
Sbjct: 3767 IQVTWFKNNKELSESN---TVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCST 3823
Query: 105 NITI---------VESNEIITGMPASTEGAYVSSESPIRIS 136
I I +E +I+ G A + VS P IS
Sbjct: 3824 EIVIKEPPSFIKTLEPADIVRGTNALLQ-CEVSGTGPFEIS 3863
Score = 44.3 bits (103), Expect = 3e-04
Identities = 32/131 (24%), Positives = 58/131 (44%), Gaps = 14/131 (10%)
Query: 12 TALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKP 71
++ PP ++ +K+ E + L CE S W+K+ +L K KI K
Sbjct: 5520 SSFPPIVETLKNAEVS------LECELSGT-PPFEVVWYKDKRQLRSSKK---YKIASKN 5569
Query: 72 GKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSES 131
+ + I +D GEY CK +++G+D+ + + E ++ + + T V +
Sbjct: 5570 FHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPPRFVSKLNSLT----VVAGE 5625
Query: 132 PIRISVSTEGA 142
P + S EGA
Sbjct: 5626 PAELQASIEGA 5636
Score = 44.3 bits (103), Expect = 3e-04
Identities = 34/151 (22%), Positives = 64/151 (42%), Gaps = 17/151 (11%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
P +K+++ + + G L+C+ + + W+K +L K+ + +
Sbjct: 7961 PYFVKQLEPVKVSVGDSASLQCQLAGT-PEIGVSWYKGDTKLRPTT---TYKMHFRNNVA 8016
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESN------------EIITGMPAST 122
L N+ + DSGEY+CK + +G SAS +T+ E + G+P
Sbjct: 8017 TLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVF 8076
Query: 123 EGAYVSSESPIRISVSTEGANTSSSTSTSTT 153
+ A +S PI +S +G S + T+
Sbjct: 8077 DCA-ISGSEPISVSWYKDGKPLKDSPNVQTS 8106
Score = 43.1 bits (100), Expect = 8e-04
Identities = 45/196 (22%), Positives = 78/196 (39%), Gaps = 13/196 (6%)
Query: 2 GKGRAGRVGTTALPPR-LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
G+ G + +T PP + E++ E+A G + L+C+ + + W+K +L
Sbjct: 6065 GRDVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQVAGT-PEITVSWYKGDTKLR--- 6120
Query: 61 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 120
+ + L NK ++ DSGEY CK + +G S+ I E +P
Sbjct: 6121 PTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQ-----LPP 6175
Query: 121 STEGAYVSSESPIRISVS-TEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMV- 178
S E + + V+ T N S+ L++ E +T V+ +
Sbjct: 6176 SFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFVDNVATLKIL 6235
Query: 179 -KDLSNPSRYLCKCPN 193
DLS+ +Y C N
Sbjct: 6236 QTDLSHSGQYSCSASN 6251
Score = 42.7 bits (99), Expect = 0.001
Identities = 29/117 (24%), Positives = 51/117 (43%), Gaps = 13/117 (11%)
Query: 29 GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGE 88
G + L C +R +W K G E+ ++ G + L + + ADSG+
Sbjct: 8360 GEYVQLSCHVQGS-EPIRIQWLKAGREIKPSDR---CSFSFASGTAVLELRDVAKADSGD 8415
Query: 89 YMCKVISKLGNDSASANITIVESNEIITGMPASTEGA------YVSSESPIRISVST 139
Y+CK + G+D+ + +TI + + PA+ + A +VS IR+ T
Sbjct: 8416 YVCKASNVAGSDTTKSKVTIKDKPAV---APATKKAAVDGRLFFVSEPQSIRVVEKT 8469
Score = 42.4 bits (98), Expect = 0.001
Identities = 46/191 (24%), Positives = 80/191 (41%), Gaps = 17/191 (8%)
Query: 15 PPR-LKEMKSQESA-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
PP+ +K++++ + AG L C+ + +R WF+N +EL +K + I
Sbjct: 5422 PPKFVKKLEASKIVKAGDSSRLECKIAGS-PEIRVVWFRNEHELPASDKYRMTFIDSV-- 5478
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTE---GAYVSS 129
+ +++N S DSG+++C+ + G+ S S + IV+ + + P E A VS
Sbjct: 5479 -AVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKV-IVKEPPVFSSFPPIVETLKNAEVSL 5536
Query: 130 ESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLC 189
E + T +S K A K ++ + D S+ Y C
Sbjct: 5537 ECELS---GTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIH----ILNVDTSDIGEYHC 5589
Query: 190 KCPNEFTGDRC 200
K NE D C
Sbjct: 5590 KAQNEVGSDTC 5600
Score = 42.0 bits (97), Expect = 0.002
Identities = 29/113 (25%), Positives = 52/113 (46%), Gaps = 13/113 (11%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
P ++++K + G+ +VL C S + + WF++GNE+ K Q+
Sbjct: 6741 PSFIRKLKDVNAILGASVVLECRVSGS-APISVGWFQDGNEIVSGPKCQS---SFSENVC 6796
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITIVE---------SNEIITGM 118
L ++ +D+G Y C + G+D SA +T+ E S E++ GM
Sbjct: 6797 TLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGM 6849
Score = 41.6 bits (96), Expect = 0.002
Identities = 27/94 (28%), Positives = 47/94 (50%), Gaps = 4/94 (4%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
P ++ ++ E+ G L+C+ +R W+K +L ++ P K+Q K +
Sbjct: 7020 PYFIEPLEHVEAVIGEPATLQCKVDGT-PEIRISWYKEHTKL--RSAPA-YKMQFKNNVA 7075
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITI 108
L INK +D GEY CK + +G ++SA + I
Sbjct: 7076 SLVINKVDHSDVGEYSCKADNSVGAVASSAVLVI 7109
Score = 41.2 bits (95), Expect = 0.003
Identities = 37/146 (25%), Positives = 60/146 (41%), Gaps = 18/146 (12%)
Query: 9 VGTTAL--PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIK 66
VG+ AL PPR + S S K V T + WFK+ E+ R++ NI
Sbjct: 7483 VGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRES--DNIW 7540
Query: 67 IQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAY 126
I + L+ ++ A++G+Y C++ + G A ++++E I+
Sbjct: 7541 ISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIV----------- 7589
Query: 127 VSSESPIRISVSTEGANTSSSTSTST 152
E P I V+T T T T
Sbjct: 7590 ---EKPESIKVTTGDTCTLECTVAGT 7612
Score = 40.8 bits (94), Expect = 0.004
Identities = 44/186 (23%), Positives = 74/186 (39%), Gaps = 17/186 (9%)
Query: 19 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 78
KE K E ++L E + WFK+ N + R + IQ L+I
Sbjct: 4397 KEFKPIEVLKEYDVMLLAEVAGT-PPFEITWFKD-NTILRSGRKYKTFIQDH--LVSLQI 4452
Query: 79 NKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVS 138
K AD+GEY C+V +++G+ SA +T+ E I + S S +R +
Sbjct: 4453 LKFVAADAGEYQCRVTNEVGSSICSARVTLREPPSFI---------KKIESTSSLRGGTA 4503
Query: 139 TEGANTSSSTSTSTTGTSHLVKCAEKEK---TFCVNGGECFMVK-DLSNPSRYLCKCPNE 194
A S + T + E + TF N ++ ++ + +Y+C+ N+
Sbjct: 4504 AFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKND 4563
Query: 195 FTGDRC 200
RC
Sbjct: 4564 AGIQRC 4569
Score = 40.0 bits (92), Expect = 0.006
Identities = 25/94 (26%), Positives = 39/94 (41%), Gaps = 4/94 (4%)
Query: 28 AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSG 87
AG C + +R W K+ E+ N I LRI K DSG
Sbjct: 6284 AGESADFECHVTGA-QPMRITWSKDNKEIRPGG---NYTITCVGNTPHLRILKVGKGDSG 6339
Query: 88 EYMCKVISKLGNDSASANITIVESNEIITGMPAS 121
+Y C+ + +G D SA +++ E + + + AS
Sbjct: 6340 QYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEAS 6373
Score = 39.3 bits (90), Expect = 0.011
Identities = 25/102 (24%), Positives = 51/102 (50%), Gaps = 4/102 (3%)
Query: 15 PPR-LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 73
PPR +K++ + G + LR + + W K+ E+ R++ +N +I
Sbjct: 6550 PPRFVKKLSDTSTLIGDAVELRAIVEG-FQPISVVWLKDRGEVIRES--ENTRISFIDNI 6606
Query: 74 SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEII 115
+ L++ ++SG+Y+C++ + G SA +T++E II
Sbjct: 6607 ATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARII 6648
Score = 38.9 bits (89), Expect = 0.014
Identities = 20/86 (23%), Positives = 40/86 (46%), Gaps = 4/86 (4%)
Query: 25 ESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLA 84
++ G C + ++ W K+ E+ K Q ++ + L+++K
Sbjct: 8163 DAVVGESADFECHVTGT-QPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKG--- 8218
Query: 85 DSGEYMCKVISKLGNDSASANITIVE 110
DSG+Y C ++++G DS +A + I E
Sbjct: 8219 DSGQYTCYAVNEVGKDSCTAQLNIKE 8244
Score = 38.9 bits (89), Expect = 0.014
Identities = 35/162 (21%), Positives = 64/162 (39%), Gaps = 11/162 (6%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFK---WFKNGNELNRKNKPQNIKIQKKP 71
PP++ + E+ SK + + E S LR K W+K+G +L Q
Sbjct: 32717 PPKITQFLKAEA---SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH--YSAD 32771
Query: 72 GKSELRINKASLADSGEYMCKVISKLGNDSASANI---TIVESNEIITGMPASTEGAYVS 128
G EL+IN + +D GEY+C++ + G + +E ++ + + + +
Sbjct: 32772 GTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKT 32831
Query: 129 SESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCV 170
+ES + + SS TG ++ F V
Sbjct: 32832 TESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAV 32873
Score = 38.5 bits (88), Expect = 0.019
Identities = 23/63 (36%), Positives = 32/63 (50%), Gaps = 3/63 (4%)
Query: 48 KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 107
KWFK+G EL +K KI S L+I DSGEY +V + +G S A I
Sbjct: 4611 KWFKDGQELTLGSK---YKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARIN 4667
Query: 108 IVE 110
+++
Sbjct: 4668 VLD 4670
Score = 38.5 bits (88), Expect = 0.019
Identities = 23/84 (27%), Positives = 37/84 (44%), Gaps = 4/84 (4%)
Query: 25 ESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLA 84
E+ G+ + L CE W+K+ EL K KI + + + I A
Sbjct: 7409 ETLKGADVHLECELQGT-PPFHVSWYKDKRELRSGKK---YKIMSENFLTSIHILNVDAA 7464
Query: 85 DSGEYMCKVISKLGNDSASANITI 108
D GEY CK + +G+D+ +I +
Sbjct: 7465 DIGEYQCKATNDVGSDTCVGSIAL 7488
Score = 38.5 bits (88), Expect = 0.019
Identities = 39/152 (25%), Positives = 62/152 (40%), Gaps = 19/152 (12%)
Query: 14 LPPRLKEMKSQ--ESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKP 71
+PP + S+ E G+ L + + W+KN E+ + N +I K
Sbjct: 8247 IPPSFTKRLSETVEETEGNSFKLEGRVAGS-QPITVAWYKNNIEIQPTS---NCEITFKN 8302
Query: 72 GKSELRINKASLADSGEYMCKVISKLGNDSASANITIVES------NEIITGMPASTEGA 125
L++ KA + D+G Y CKV + G+ +++I I E ++ +T + S EG
Sbjct: 8303 NTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVS-EGE 8361
Query: 126 Y------VSSESPIRISVSTEGANTSSSTSTS 151
Y V PIRI G S S
Sbjct: 8362 YVQLSCHVQGSEPIRIQWLKAGREIKPSDRCS 8393
Score = 37.7 bits (86), Expect = 0.032
Identities = 26/109 (23%), Positives = 45/109 (41%), Gaps = 4/109 (3%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
P + +K+ G + L C S Y S W++ ++ + +I + G +
Sbjct: 943 PTLVSGLKNVTVIEGESVTLECHISG-YPSPTVTWYREDYQIESSI---DFQITFQSGIA 998
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTE 123
L I +A DSG + C +++ G S S + + S E A TE
Sbjct: 999 RLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE 1047
Score = 37.4 bits (85), Expect = 0.042
Identities = 38/194 (19%), Positives = 78/194 (40%), Gaps = 27/194 (13%)
Query: 11 TTALPPRLKEM-KSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK 69
T PP E +SQ+ +++ L+ + + KWFK+ EL+ + K
Sbjct: 4763 TVKEPPYFVEKPQSQDVNPNTRVQLKALVGGT-APMTIKWFKDNKELHSGAARS---VWK 4818
Query: 70 KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNE---------IITGMPA 120
+ L + A DSG Y+C++ + +G ++ A + + E + ++ +
Sbjct: 4819 DDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPSPVLVLRNGQS 4878
Query: 121 STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 180
+T ++ IR+S +G + T H + + TF ++G
Sbjct: 4879 TTFECQITGTPKIRVSWYLDG-------NEITAIQKHGISFIDGLATFQISGAR------ 4925
Query: 181 LSNPSRYLCKCPNE 194
+ N Y+C+ N+
Sbjct: 4926 VENSGTYVCEARND 4939
Score = 37.4 bits (85), Expect = 0.042
Identities = 39/168 (23%), Positives = 66/168 (39%), Gaps = 26/168 (15%)
Query: 46 RFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASAN 105
+ KWFK EL ++ I + +EL + + +SG+Y C V + G+ S + +
Sbjct: 6864 KVKWFKGSRELV---PGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTH 6920
Query: 106 ITIVESNEII---------TGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTS 156
+ + E + TG P E Y + PI +S + S S S T T
Sbjct: 6921 LFVKEPATFVKRLADFSVETGSPIVLEATYTGT-PPISVSWIKDEYLISQSERCSITMT- 6978
Query: 157 HLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV 204
EK+ + + + + ++Y C NE D C+ V
Sbjct: 6979 --------EKSTILE----ILESTIEDYAQYSCLIENEAGQDICEALV 7014
Score = 37.4 bits (85), Expect = 0.042
Identities = 39/183 (21%), Positives = 64/183 (34%), Gaps = 23/183 (12%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
+K + G L+L T + + W KNG + Q I + L
Sbjct: 7871 VKRLNDYSIEKGKPLILE-GTFTGTPPISVTWKKNGINVTPS---QRCNITTTEKSAILE 7926
Query: 78 INKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISV 137
I +++ D+G+Y C + + G DS SA I I+E +V P+++SV
Sbjct: 7927 IPSSTVEDAGQYNCYIENASGKDSCSAQILILE------------PPYFVKQLEPVKVSV 7974
Query: 138 STEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVN-------GGECFMVKDLSNPSRYLCK 190
+ T G S + T F D+++ Y+CK
Sbjct: 7975 GDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICK 8034
Query: 191 CPN 193
N
Sbjct: 8035 AEN 8037
Score = 37.4 bits (85), Expect = 0.042
Identities = 16/60 (26%), Positives = 28/60 (46%)
Query: 49 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
W+K+G ++ + + + G +L IN + D EY +K G DS A +T+
Sbjct: 31723 WYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 31782
Score = 36.6 bits (83), Expect = 0.071
Identities = 38/177 (21%), Positives = 69/177 (38%), Gaps = 11/177 (6%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
LK + G ++L T + + W K+G + K + +K L
Sbjct: 5989 LKRLSDHSVEPGKSIILE-STYTGTLPISVTWKKDGFNITTSEKCNIVTTEKT---CILE 6044
Query: 78 INKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISV 137
I ++ D+G+Y C++ ++ G D A ++ +E +T + E A S +S+
Sbjct: 6045 ILNSTKRDAGQYSCEIENEAGRDVCGALVSTLEPPYFVTEL-EPLEAAVGDS-----VSL 6098
Query: 138 STEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVK-DLSNPSRYLCKCPN 193
+ A T T + G + L E F N K ++++ Y CK N
Sbjct: 6099 QCQVAGTPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAEN 6155
Score = 36.2 bits (82), Expect = 0.093
Identities = 29/106 (27%), Positives = 43/106 (40%), Gaps = 5/106 (4%)
Query: 11 TTALPPR-LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK 69
T A PP L KS + G C T + + W K+G L+ N +I
Sbjct: 3546 TEAYPPTFLSRPKSLTTFVGKAAKFIC-TVTGTPVIETIWQKDGAALSPS---PNWRISD 3601
Query: 70 KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEII 115
K L ++ ++ D G Y CK +K G D A + I++ I
Sbjct: 3602 AENKHILELSNLTIQDRGVYSCKASNKFGADICQAELIIIDKPHFI 3647
Score = 36.2 bits (82), Expect = 0.093
Identities = 28/108 (25%), Positives = 47/108 (43%), Gaps = 5/108 (4%)
Query: 2 GKGRAGRVGTTALPPRLKEMKSQESAA-GSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
G V T P R+ E + G+ L C + L KWFK+G EL+ +
Sbjct: 6631 GMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVVTGT-PELSAKWFKDGRELSADS 6689
Query: 61 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
K I K + L+I A ++D G Y +V + +G + + ++ +
Sbjct: 6690 KHHITFINK---VASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHV 6734
Score = 36.2 bits (82), Expect = 0.093
Identities = 20/60 (33%), Positives = 31/60 (51%), Gaps = 3/60 (5%)
Query: 49 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
W K+G + + K K+ + G L I+K +DSG Y C V + G+ S+S +TI
Sbjct: 32885 WTKDGKAITQGGK---YKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 32941
Score = 35.4 bits (80), Expect = 0.16
Identities = 41/184 (22%), Positives = 73/184 (39%), Gaps = 17/184 (9%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
P +K ++ + G+ +L+CE S WFK+ ++ R +K + QK
Sbjct: 3831 PSFIKTLEPADIVRGTNALLQCEVSGT-GPFEISWFKDKKQI-RSSKKYRLFSQKS--LV 3886
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMP--ASTEGAYVSSESP 132
L I + AD GEY C V +++G A + E + + + G V+ ++
Sbjct: 3887 CLEIFSFNSADVGEYECVVANEVGKCGCMATHLLKEPPTFVKKVDDLIALGGQTVTLQAA 3946
Query: 133 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD--LSNPSRYLCK 190
+R S S + +++ K K NG ++ D +S +Y C
Sbjct: 3947 VR---------GSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCL 3997
Query: 191 CPNE 194
NE
Sbjct: 3998 AENE 4001
Score = 35.4 bits (80), Expect = 0.16
Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 2/43 (4%)
Query: 19 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNK 61
K ++ Q G+ VL CE S E + + KWFKNG E+ + K
Sbjct: 12289 KPLEDQTVEEGATAVLECEVSRE--NAKVKWFKNGTEILKSKK 12329
Score = 35.0 bits (79), Expect = 0.21
Identities = 24/103 (23%), Positives = 42/103 (40%), Gaps = 5/103 (4%)
Query: 9 VGTTALPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 67
V A+PP + +K+ G+ +L C+ + S + WF ++ K Q
Sbjct: 5793 VSDRAVPPSFTRRLKNTGGVLGASCILECKVAGS-SPISVAWFHEKTKIVSGAKYQTTF- 5850
Query: 68 QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
L++N +D G Y C + G+D A +T+ E
Sbjct: 5851 --SDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQE 5891
Score = 35.0 bits (79), Expect = 0.21
Identities = 31/121 (25%), Positives = 53/121 (43%), Gaps = 11/121 (9%)
Query: 11 TTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNI-KIQK 69
T L P +K+ + + AG +VL + + W K G ++ +P +I +I
Sbjct: 20377 TIVLDPTIKDGLTIK--AGDTIVLNAISILGKPLPKSSWSKAGKDI----RPSDITQITS 20430
Query: 70 KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS 129
P S L I A+ D+GEY + G +T+++ + G P E + VS+
Sbjct: 20431 TPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLD----VPGPPGPVEISNVSA 20486
Query: 130 E 130
E
Sbjct: 20487 E 20487
Score = 34.7 bits (78), Expect = 0.27
Identities = 23/99 (23%), Positives = 40/99 (40%), Gaps = 4/99 (4%)
Query: 23 SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKAS 82
S + A G +C + + ++ W K+ E+ N K+ + L + K
Sbjct: 7220 SVDLALGESGTFKCHVTGT-APIKITWAKDNREIRPGG---NYKMTLVENTATLTVLKVG 7275
Query: 83 LADSGEYMCKVISKLGNDSASANITIVESNEIITGMPAS 121
D+G+Y C + G DS SA + + E I + S
Sbjct: 7276 KGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEPS 7314
Score = 34.7 bits (78), Expect = 0.27
Identities = 22/107 (20%), Positives = 44/107 (41%), Gaps = 3/107 (2%)
Query: 8 RVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 67
+V + + P ++ G + C+ + S + W+ +L K +I
Sbjct: 31561 KVASIEIGPVSGQIMHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEK---YEI 31617
Query: 68 QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEI 114
+ G + L + + D G Y CKV++ G DS+ A + + E+
Sbjct: 31618 TYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREV 31664
Score = 34.3 bits (77), Expect = 0.35
Identities = 34/164 (20%), Positives = 62/164 (37%), Gaps = 26/164 (15%)
Query: 46 RFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASAN 105
+ WF+ EL + ++ I + +EL + ++ SGEY C V + G S +
Sbjct: 5923 KVNWFRGARELVKGDR---CNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTR 5979
Query: 106 ITIVE---------SNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTS 156
+ + E + + G E Y + PI ++ +G N ++S + T
Sbjct: 5980 LFVKEPAAFLKRLSDHSVEPGKSIILESTYTGT-LPISVTWKKDGFNITTSEKCNIVTT- 6037
Query: 157 HLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRC 200
EKT + + + +Y C+ NE D C
Sbjct: 6038 --------EKTCILE----ILNSTKRDAGQYSCEIENEAGRDVC 6069
Score = 33.9 bits (76), Expect = 0.46
Identities = 25/102 (24%), Positives = 49/102 (48%), Gaps = 4/102 (3%)
Query: 15 PPR-LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 73
PPR + ++ S AG L+ + +W K E+ R++ +NI+I
Sbjct: 5609 PPRFVSKLNSLTVVAGEPAELQASIEGA-QPIFVQWLKEKEEVIRES--ENIRITFVENV 5665
Query: 74 SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEII 115
+ L+ KA A++G+Y+C++ + G A + ++E I+
Sbjct: 5666 ATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIV 5707
Score = 33.9 bits (76), Expect = 0.46
Identities = 30/123 (24%), Positives = 52/123 (42%), Gaps = 11/123 (8%)
Query: 18 LKEMK----SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 73
+KE+K ++ GS + C S S+ W K+G+ + K + I K
Sbjct: 11118 VKEIKDIILTESEFVGSSAIFECLVSP--STAITTWMKDGSNIRESPKHRFIADGKD--- 11172
Query: 74 SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPI 133
+L I L+D+GEY C + +LGN ++ +V + + E V P+
Sbjct: 11173 RKLHIIDVQLSDAGEYTC--VLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPL 11230
Query: 134 RIS 136
+S
Sbjct: 11231 YLS 11233
Score = 33.5 bits (75), Expect = 0.60
Identities = 26/97 (26%), Positives = 43/97 (44%), Gaps = 2/97 (2%)
Query: 10 GTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK 69
G A P + + Q+ G +V C+ + W K+G L + + K
Sbjct: 1077 GEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVY-WKKSGVPLTTGYR-YKVSYNK 1134
Query: 70 KPGKSELRINKASLADSGEYMCKVISKLGNDSASANI 106
+ G+ +L I+ D+GEY V +K G SASA++
Sbjct: 1135 QTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1171
Score = 33.5 bits (75), Expect = 0.60
Identities = 20/76 (26%), Positives = 36/76 (47%), Gaps = 3/76 (3%)
Query: 46 RFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASAN 105
+ KWFK+ EL K I + S L + + +G+Y C V + +G+DS +
Sbjct: 5360 KIKWFKDDVELVSGPK---CFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTM 5416
Query: 106 ITIVESNEIITGMPAS 121
+ + E + + + AS
Sbjct: 5417 LLVTEPPKFVKKLEAS 5432
Score = 32.7 bits (73), Expect = 1.0
Identities = 20/82 (24%), Positives = 36/82 (43%), Gaps = 4/82 (4%)
Query: 29 GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGE 88
G C+ + +R W+ +GNE+ K I G + +I+ A + +SG
Sbjct: 4876 GQSTTFECQITGT-PKIRVSWYLDGNEITAIQKHG---ISFIDGLATFQISGARVENSGT 4931
Query: 89 YMCKVISKLGNDSASANITIVE 110
Y+C+ + G S S + + E
Sbjct: 4932 YVCEARNDAGTASCSIELKVKE 4953
Score = 32.7 bits (73), Expect = 1.0
Identities = 15/66 (22%), Positives = 35/66 (53%), Gaps = 3/66 (4%)
Query: 45 LRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASA 104
++ W+K+ E+ +K ++ + L ++ S+ DSG+Y C+ + G+ S+S
Sbjct: 7335 IKVLWYKDETEIQESSK---FRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSST 7391
Query: 105 NITIVE 110
++ + E
Sbjct: 7392 SLKVKE 7397
Score = 32.7 bits (73), Expect = 1.0
Identities = 27/97 (27%), Positives = 44/97 (45%), Gaps = 8/97 (8%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
LK+ + +E ++V CE ++E + KWF+N + +K I +K LR
Sbjct: 12646 LKDTRVKEQ---QEVVFNCEVNTE--GAKAKWFRNEEAIFDSSK---YIILQKDLVYTLR 12697
Query: 78 INKASLADSGEYMCKVISKLGNDSASANITIVESNEI 114
I A L D Y + + G + SA IVE ++
Sbjct: 12698 IRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDL 12734
Score = 32.7 bits (73), Expect = 1.0
Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 5/76 (6%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
++ ++ Q V C+ S E +++ KW++NG E+ K K +K L
Sbjct: 12826 VEHLEDQTVTEFDDAVFSCQLSREKANV--KWYRNGREIKEGKK---YKFEKDGSIHRLI 12880
Query: 78 INKASLADSGEYMCKV 93
I L D EY C V
Sbjct: 12881 IKDCRLDDECEYACGV 12896
Score = 32.7 bits (73), Expect = 1.0
Identities = 16/61 (26%), Positives = 34/61 (55%), Gaps = 3/61 (4%)
Query: 49 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
W K+G E+ ++ + ++ + L + K+ AD+G Y + +KLG+ +AS N+ +
Sbjct: 14420 WHKDGKEVKASDR---LTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKV 14476
Query: 109 V 109
+
Sbjct: 14477 I 14477
Score = 32.0 bits (71), Expect = 1.8
Identities = 23/75 (30%), Positives = 33/75 (44%), Gaps = 5/75 (6%)
Query: 19 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 78
K + Q A + V CE ++ S + +W ++G L N NI+ + K L I
Sbjct: 2624 KPLTDQTVAESQEAVFECEVANPDS--KGEWLRDGKHLPLTN---NIRSESDGHKRRLII 2678
Query: 79 NKASLADSGEYMCKV 93
L D GEY KV
Sbjct: 2679 AATKLDDIGEYTYKV 2693
Score = 32.0 bits (71), Expect = 1.8
Identities = 24/102 (23%), Positives = 46/102 (45%), Gaps = 3/102 (2%)
Query: 8 RVGTTALPPRLKEMKSQESA-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIK 66
+ G +PP+++ + S S G L + C + E + W G +++ + + +
Sbjct: 33321 KAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTP-EVTWSCGGRKIHSQEQGR-FH 33378
Query: 67 IQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
I+ + L I D G Y + ++ G+DSA+ NI I
Sbjct: 33379 IENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 33420
Score = 31.6 bits (70), Expect = 2.3
Identities = 19/72 (26%), Positives = 33/72 (45%), Gaps = 8/72 (11%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
LK++ ++E K + E + Y + +KW KNG E+ +K Q ++ K L
Sbjct: 2975 LKDINAEE-----KDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQ---MRTKKLTHSLN 3026
Query: 78 INKASLADSGEY 89
I D+ +Y
Sbjct: 3027 IRNVHFGDAADY 3038
Score = 31.2 bits (69), Expect = 3.0
Identities = 34/172 (19%), Positives = 68/172 (39%), Gaps = 16/172 (9%)
Query: 6 AGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNI 65
+ RV P +K+++S S G + + W K+ +E+ + NI
Sbjct: 4477 SARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGSLP-ITVTWLKDSDEITEDD---NI 4532
Query: 66 KIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE---------SNEIIT 116
++ + + L ++ + G+Y+C+ + G SA +++ E S ++
Sbjct: 4533 RMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVKEPATITEEAVSIDVTQ 4592
Query: 117 GMPASTEGAYVSSESPIRISVSTEGANTS--SSTSTSTTGTSHLVKCAEKEK 166
G PA+ + + S I +G + S S T T ++K EK
Sbjct: 4593 GDPATLQVKF-SGTKEITAKWFKDGQELTLGSKYKISVTDTVSILKIISTEK 4643
Score = 30.8 bits (68), Expect = 3.9
Identities = 24/103 (23%), Positives = 44/103 (42%), Gaps = 8/103 (7%)
Query: 48 KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 107
+W +G L N+ +++ + G L A DSG C+ +K G D SA +
Sbjct: 1737 EWLHDGKPLEAANR---LRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLI 1793
Query: 108 IVESNEII--TGMPASTEGAYVSSESPIRISVSTEGANTSSST 148
+ + ++ + +P +G E ++ EGA T +T
Sbjct: 1794 VKDEKSLVEESQLPEGRKGLQRIEELE---RMAHEGALTGVTT 1833
Score = 30.8 bits (68), Expect = 3.9
Identities = 21/96 (21%), Positives = 44/96 (45%), Gaps = 10/96 (10%)
Query: 46 RFKWFKNGNELNRKNKPQNI---KIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSA 102
+ +W KN + + I ++ + K+EL I KA D G Y ++LG+
Sbjct: 15429 KIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFR 15488
Query: 103 SANITIVE-----SNEIITGMPASTEGAYVSSESPI 133
+ ++ + + N +T + A E Y++ ++P+
Sbjct: 15489 NVHVEVYDRPSPPRNLAVTDIKA--ESCYLTWDAPL 15522
Score = 30.4 bits (67), Expect = 5.1
Identities = 40/185 (21%), Positives = 66/185 (35%), Gaps = 30/185 (16%)
Query: 29 GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGE 88
G L C+ + L +W+K+G L K + K S LRI D+G
Sbjct: 5718 GETCTLECKVAGT-PELSVEWYKDGKLLTSSQKHKFSFYNKI---SSLRILSVERQDAGT 5773
Query: 89 YMCKVISKLGNDSASANITI------------VESNEIITGMPASTEGAYVSSESPIRIS 136
Y +V + +G S +A + + +++ + G E V+ SPI ++
Sbjct: 5774 YTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILE-CKVAGSSPISVA 5832
Query: 137 VSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFT 196
E S TT + ++ T +N D S+ Y C N
Sbjct: 5833 WFHEKTKIVSGAKYQTTFSDNVC-------TLQLNS------LDSSDMGNYTCVAANVAG 5879
Query: 197 GDRCQ 201
D C+
Sbjct: 5880 SDECR 5884
Score = 30.0 bits (66), Expect = 6.7
Identities = 22/100 (22%), Positives = 47/100 (47%), Gaps = 12/100 (12%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
LK++ ++E + V E S + ++R KWFKN L + +++ +Q + +
Sbjct: 11935 LKDVTAKEKESA---VFTVELS--HDNIRVKWFKNDQRL---HTTRSVSMQDEGKTHSIT 11986
Query: 78 INKASLADSGEYMCKVISKLGNDSASANITIVESNEIITG 117
S+ D+ + + + S+ A +T++E + TG
Sbjct: 11987 FKDLSIDDTSQIRVEAMGM----SSEAKLTVLEGDPYFTG 12022
Score = 29.6 bits (65), Expect = 8.7
Identities = 16/63 (25%), Positives = 31/63 (49%), Gaps = 2/63 (3%)
Query: 48 KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 107
KW K + + N+ + I +K +++L I + DSG Y C ++ G ++ N+
Sbjct: 8486 KWTKG--KWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQ 8543
Query: 108 IVE 110
+ E
Sbjct: 8544 VDE 8546
Score = 29.6 bits (65), Expect = 8.7
Identities = 14/62 (22%), Positives = 31/62 (50%), Gaps = 1/62 (1%)
Query: 49 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
W K+ + + P+ +KI + S+ + KA +D G+Y+ + G+ A A + +
Sbjct: 18235 WTKDKDATDLTRSPR-VKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNV 18293
Query: 109 VE 110
++
Sbjct: 18294 LD 18295
Score = 29.6 bits (65), Expect = 8.7
Identities = 38/161 (23%), Positives = 60/161 (37%), Gaps = 13/161 (8%)
Query: 3 KGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKP 62
K ++ TT L + +S G C+T E W + G L+ +
Sbjct: 32549 KSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPT-VTWLRKGQVLSTSARH 32607
Query: 63 QNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE---SNEIITGMP 119
Q + KS I+ +D G Y V + G A +TI + + + +T P
Sbjct: 32608 Q---VTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPP 32664
Query: 120 --ASTEGAYVSSE---SPIRISVSTEGANTSSSTSTSTTGT 155
S E S E SP R+ S E ++ + + T T T
Sbjct: 32665 RVKSPEPRVKSPEAVKSPKRVK-SPEPSHPKAVSPTETKPT 32704
>gi|110349717 titin isoform novex-2 [Homo sapiens]
Length = 27118
Score = 56.2 bits (134), Expect = 9e-08
Identities = 41/151 (27%), Positives = 76/151 (50%), Gaps = 13/151 (8%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
P + + +SQ G ++ CE S E S +WFKN ++ + N+ I +
Sbjct: 26829 PAFISQPRSQNINEGQNVLFTCEISGEPSP-EIEWFKNNLPISISS---NVSISRSRNVY 26884
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITIV-----ESNEII--TGMPASTEGAYV 127
L I AS++DSG+Y K + G SA+A++ ++ S E++ T S +G++
Sbjct: 26885 SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSF- 26943
Query: 128 SSESPIRISVSTEGANTSSSTSTSTTGTSHL 158
S +++S S + A+ SS +S+S + + +
Sbjct: 26944 -SSQSVQMSASKQEASFSSFSSSSASSMTEM 26973
Score = 49.7 bits (117), Expect = 8e-06
Identities = 30/96 (31%), Positives = 48/96 (50%), Gaps = 4/96 (4%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
A P ++++ E A G CE S ++RF+WFK G E+ +K I+
Sbjct: 4527 AAPVIKRKIEPLEVALGHLAKFTCEIQSA-PNVRFQWFKAGREIYESDK---CSIRSSKY 4582
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
S L I + + D GEY CK ++ G+ S +A +T+
Sbjct: 4583 ISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 4618
Score = 45.4 bits (106), Expect = 2e-04
Identities = 34/108 (31%), Positives = 50/108 (46%), Gaps = 11/108 (10%)
Query: 31 KLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM 90
++ L+CE S + + KWFK+G E+ K I+ + L+I KA L D GEY+
Sbjct: 5374 EITLKCEVSKD---VPVKWFKDGEEIVPSPK---YSIKADGLRRILKIKKADLKDKGEYV 5427
Query: 91 CKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVS 138
C G D AN+T VE+ I P +V + I +S
Sbjct: 5428 C----DCGTDKTKANVT-VEARLIKVEKPLYGVEVFVGETAHFEIELS 5470
Score = 44.7 bits (104), Expect = 3e-04
Identities = 50/193 (25%), Positives = 78/193 (40%), Gaps = 26/193 (13%)
Query: 36 CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 95
CE S E + + KWFK+G E+ + K I K L INK L D EY C+V +
Sbjct: 6090 CELSRE--NAKVKWFKDGAEIKKGKK---YDIISKGAVRILVINKCLLDDEAEYSCEVRT 6144
Query: 96 KLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRI--SVSTEGANT---SSSTST 150
S +T++E + T A+ E VS I++ VS GA
Sbjct: 6145 A----RTSGMLTVLEEEAVFTKNLANIE---VSETDTIKLVCEVSKPGAEVIWYKGDEEI 6197
Query: 151 STTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY- 209
TG ++ K N L + Y C+ P+ T + + + +A+ +
Sbjct: 6198 IETGRYEILTEGRKRILVIQNA-------HLEDAGNYNCRLPSSRTDGKVKVHELAAEFI 6250
Query: 210 -KHLGIEFMEAEE 221
K +E +E E+
Sbjct: 6251 SKPQNLEILEGEK 6263
Score = 38.9 bits (89), Expect = 0.014
Identities = 35/162 (21%), Positives = 64/162 (39%), Gaps = 11/162 (6%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFK---WFKNGNELNRKNKPQNIKIQKKP 71
PP++ + E+ SK + + E S LR K W+K+G +L Q
Sbjct: 26412 PPKITQFLKAEA---SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH--YSAD 26466
Query: 72 GKSELRINKASLADSGEYMCKVISKLGNDSASANI---TIVESNEIITGMPASTEGAYVS 128
G EL+IN + +D GEY+C++ + G + +E ++ + + + +
Sbjct: 26467 GTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKT 26526
Query: 129 SESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCV 170
+ES + + SS TG ++ F V
Sbjct: 26527 TESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAV 26568
Score = 37.7 bits (86), Expect = 0.032
Identities = 26/109 (23%), Positives = 45/109 (41%), Gaps = 4/109 (3%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
P + +K+ G + L C S Y S W++ ++ + +I + G +
Sbjct: 897 PTLVSGLKNVTVIEGESVTLECHISG-YPSPTVTWYREDYQIESSI---DFQITFQSGIA 952
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTE 123
L I +A DSG + C +++ G S S + + S E A TE
Sbjct: 953 RLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE 1001
Score = 37.4 bits (85), Expect = 0.042
Identities = 16/60 (26%), Positives = 28/60 (46%)
Query: 49 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
W+K+G ++ + + + G +L IN + D EY +K G DS A +T+
Sbjct: 25418 WYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 25477
Score = 36.2 bits (82), Expect = 0.093
Identities = 20/60 (33%), Positives = 31/60 (51%), Gaps = 3/60 (5%)
Query: 49 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
W K+G + + K K+ + G L I+K +DSG Y C V + G+ S+S +TI
Sbjct: 26580 WTKDGKAITQGGK---YKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 26636
Score = 35.4 bits (80), Expect = 0.16
Identities = 27/116 (23%), Positives = 44/116 (37%), Gaps = 3/116 (2%)
Query: 8 RVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 67
++G P LKE+K A G + E + WFK +L I
Sbjct: 3760 KLGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPT-VTWFKENKQLC--TSVYYTII 3816
Query: 68 QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTE 123
G +N DSG Y+CK + LG + +A + ++ + +T P +
Sbjct: 3817 HNPNGSGTFIVNDPQREDSGLYICKAENMLGESTCAAELLVLLEDTDMTDTPCKAK 3872
Score = 35.4 bits (80), Expect = 0.16
Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 2/43 (4%)
Query: 19 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNK 61
K ++ Q G+ VL CE S E + + KWFKNG E+ + K
Sbjct: 5984 KPLEDQTVEEGATAVLECEVSRE--NAKVKWFKNGTEILKSKK 6024
Score = 35.0 bits (79), Expect = 0.21
Identities = 31/121 (25%), Positives = 53/121 (43%), Gaps = 11/121 (9%)
Query: 11 TTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNI-KIQK 69
T L P +K+ + + AG +VL + + W K G ++ +P +I +I
Sbjct: 14072 TIVLDPTIKDGLTIK--AGDTIVLNAISILGKPLPKSSWSKAGKDI----RPSDITQITS 14125
Query: 70 KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS 129
P S L I A+ D+GEY + G +T+++ + G P E + VS+
Sbjct: 14126 TPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLD----VPGPPGPVEISNVSA 14181
Query: 130 E 130
E
Sbjct: 14182 E 14182
Score = 34.7 bits (78), Expect = 0.27
Identities = 22/107 (20%), Positives = 44/107 (41%), Gaps = 3/107 (2%)
Query: 8 RVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 67
+V + + P ++ G + C+ + S + W+ +L K +I
Sbjct: 25256 KVASIEIGPVSGQIMHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEK---YEI 25312
Query: 68 QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEI 114
+ G + L + + D G Y CKV++ G DS+ A + + E+
Sbjct: 25313 TYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREV 25359
Score = 33.9 bits (76), Expect = 0.46
Identities = 30/123 (24%), Positives = 52/123 (42%), Gaps = 11/123 (8%)
Query: 18 LKEMK----SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 73
+KE+K ++ GS + C S S+ W K+G+ + K + I K
Sbjct: 4813 VKEIKDIILTESEFVGSSAIFECLVSP--STAITTWMKDGSNIRESPKHRFIADGKD--- 4867
Query: 74 SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPI 133
+L I L+D+GEY C + +LGN ++ +V + + E V P+
Sbjct: 4868 RKLHIIDVQLSDAGEYTC--VLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPL 4925
Query: 134 RIS 136
+S
Sbjct: 4926 YLS 4928
Score = 33.5 bits (75), Expect = 0.60
Identities = 26/97 (26%), Positives = 43/97 (44%), Gaps = 2/97 (2%)
Query: 10 GTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK 69
G A P + + Q+ G +V C+ + W K+G L + + K
Sbjct: 1031 GEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVY-WKKSGVPLTTGYR-YKVSYNK 1088
Query: 70 KPGKSELRINKASLADSGEYMCKVISKLGNDSASANI 106
+ G+ +L I+ D+GEY V +K G SASA++
Sbjct: 1089 QTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1125
Score = 32.7 bits (73), Expect = 1.0
Identities = 27/97 (27%), Positives = 44/97 (45%), Gaps = 8/97 (8%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
LK+ + +E ++V CE ++E + KWF+N + +K I +K LR
Sbjct: 6341 LKDTRVKEQ---QEVVFNCEVNTE--GAKAKWFRNEEAIFDSSK---YIILQKDLVYTLR 6392
Query: 78 INKASLADSGEYMCKVISKLGNDSASANITIVESNEI 114
I A L D Y + + G + SA IVE ++
Sbjct: 6393 IRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDL 6429
Score = 32.7 bits (73), Expect = 1.0
Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 5/76 (6%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
++ ++ Q V C+ S E +++ KW++NG E+ K K +K L
Sbjct: 6521 VEHLEDQTVTEFDDAVFSCQLSREKANV--KWYRNGREIKEGKK---YKFEKDGSIHRLI 6575
Query: 78 INKASLADSGEYMCKV 93
I L D EY C V
Sbjct: 6576 IKDCRLDDECEYACGV 6591
Score = 32.7 bits (73), Expect = 1.0
Identities = 16/61 (26%), Positives = 34/61 (55%), Gaps = 3/61 (4%)
Query: 49 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
W K+G E+ ++ + ++ + L + K+ AD+G Y + +KLG+ +AS N+ +
Sbjct: 8115 WHKDGKEVKASDR---LTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKV 8171
Query: 109 V 109
+
Sbjct: 8172 I 8172
Score = 32.0 bits (71), Expect = 1.8
Identities = 23/75 (30%), Positives = 33/75 (44%), Gaps = 5/75 (6%)
Query: 19 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 78
K + Q A + V CE ++ S + +W ++G L N NI+ + K L I
Sbjct: 2578 KPLTDQTVAESQEAVFECEVANPDS--KGEWLRDGKHLPLTN---NIRSESDGHKRRLII 2632
Query: 79 NKASLADSGEYMCKV 93
L D GEY KV
Sbjct: 2633 AATKLDDIGEYTYKV 2647
Score = 32.0 bits (71), Expect = 1.8
Identities = 24/102 (23%), Positives = 46/102 (45%), Gaps = 3/102 (2%)
Query: 8 RVGTTALPPRLKEMKSQESA-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIK 66
+ G +PP+++ + S S G L + C + E + W G +++ + + +
Sbjct: 27016 KAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTP-EVTWSCGGRKIHSQEQGR-FH 27073
Query: 67 IQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
I+ + L I D G Y + ++ G+DSA+ NI I
Sbjct: 27074 IENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 27115
Score = 31.6 bits (70), Expect = 2.3
Identities = 19/72 (26%), Positives = 33/72 (45%), Gaps = 8/72 (11%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
LK++ ++E K + E + Y + +KW KNG E+ +K Q ++ K L
Sbjct: 2929 LKDINAEE-----KDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQ---MRTKKLTHSLN 2980
Query: 78 INKASLADSGEY 89
I D+ +Y
Sbjct: 2981 IRNVHFGDAADY 2992
Score = 30.8 bits (68), Expect = 3.9
Identities = 24/103 (23%), Positives = 44/103 (42%), Gaps = 8/103 (7%)
Query: 48 KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 107
+W +G L N+ +++ + G L A DSG C+ +K G D SA +
Sbjct: 1691 EWLHDGKPLEAANR---LRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLI 1747
Query: 108 IVESNEII--TGMPASTEGAYVSSESPIRISVSTEGANTSSST 148
+ + ++ + +P +G E ++ EGA T +T
Sbjct: 1748 VKDEKSLVEESQLPEGRKGLQRIEELE---RMAHEGALTGVTT 1787
Score = 30.8 bits (68), Expect = 3.9
Identities = 21/96 (21%), Positives = 44/96 (45%), Gaps = 10/96 (10%)
Query: 46 RFKWFKNGNELNRKNKPQNI---KIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSA 102
+ +W KN + + I ++ + K+EL I KA D G Y ++LG+
Sbjct: 9124 KIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFR 9183
Query: 103 SANITIVE-----SNEIITGMPASTEGAYVSSESPI 133
+ ++ + + N +T + A E Y++ ++P+
Sbjct: 9184 NVHVEVYDRPSPPRNLAVTDIKA--ESCYLTWDAPL 9217
Score = 30.0 bits (66), Expect = 6.7
Identities = 22/100 (22%), Positives = 47/100 (47%), Gaps = 12/100 (12%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
LK++ ++E + V E S + ++R KWFKN L + +++ +Q + +
Sbjct: 5630 LKDVTAKEKESA---VFTVELS--HDNIRVKWFKNDQRL---HTTRSVSMQDEGKTHSIT 5681
Query: 78 INKASLADSGEYMCKVISKLGNDSASANITIVESNEIITG 117
S+ D+ + + + S+ A +T++E + TG
Sbjct: 5682 FKDLSIDDTSQIRVEAMGM----SSEAKLTVLEGDPYFTG 5717
Score = 29.6 bits (65), Expect = 8.7
Identities = 14/62 (22%), Positives = 31/62 (50%), Gaps = 1/62 (1%)
Query: 49 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
W K+ + + P+ +KI + S+ + KA +D G+Y+ + G+ A A + +
Sbjct: 11930 WTKDKDATDLTRSPR-VKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNV 11988
Query: 109 VE 110
++
Sbjct: 11989 LD 11990
Score = 29.6 bits (65), Expect = 8.7
Identities = 38/161 (23%), Positives = 60/161 (37%), Gaps = 13/161 (8%)
Query: 3 KGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKP 62
K ++ TT L + +S G C+T E W + G L+ +
Sbjct: 26244 KSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPT-VTWLRKGQVLSTSARH 26302
Query: 63 QNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE---SNEIITGMP 119
Q + KS I+ +D G Y V + G A +TI + + + +T P
Sbjct: 26303 Q---VTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPP 26359
Query: 120 --ASTEGAYVSSE---SPIRISVSTEGANTSSSTSTSTTGT 155
S E S E SP R+ S E ++ + + T T T
Sbjct: 26360 RVKSPEPRVKSPEAVKSPKRVK-SPEPSHPKAVSPTETKPT 26399
>gi|110349713 titin isoform novex-1 [Homo sapiens]
Length = 27051
Score = 56.2 bits (134), Expect = 9e-08
Identities = 41/151 (27%), Positives = 76/151 (50%), Gaps = 13/151 (8%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
P + + +SQ G ++ CE S E S +WFKN ++ + N+ I +
Sbjct: 26762 PAFISQPRSQNINEGQNVLFTCEISGEPSP-EIEWFKNNLPISISS---NVSISRSRNVY 26817
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITIV-----ESNEII--TGMPASTEGAYV 127
L I AS++DSG+Y K + G SA+A++ ++ S E++ T S +G++
Sbjct: 26818 SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSF- 26876
Query: 128 SSESPIRISVSTEGANTSSSTSTSTTGTSHL 158
S +++S S + A+ SS +S+S + + +
Sbjct: 26877 -SSQSVQMSASKQEASFSSFSSSSASSMTEM 26906
Score = 49.7 bits (117), Expect = 8e-06
Identities = 30/96 (31%), Positives = 48/96 (50%), Gaps = 4/96 (4%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
A P ++++ E A G CE S ++RF+WFK G E+ +K I+
Sbjct: 4460 AAPVIKRKIEPLEVALGHLAKFTCEIQSA-PNVRFQWFKAGREIYESDK---CSIRSSKY 4515
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
S L I + + D GEY CK ++ G+ S +A +T+
Sbjct: 4516 ISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 4551
Score = 45.4 bits (106), Expect = 2e-04
Identities = 34/108 (31%), Positives = 50/108 (46%), Gaps = 11/108 (10%)
Query: 31 KLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM 90
++ L+CE S + + KWFK+G E+ K I+ + L+I KA L D GEY+
Sbjct: 5307 EITLKCEVSKD---VPVKWFKDGEEIVPSPK---YSIKADGLRRILKIKKADLKDKGEYV 5360
Query: 91 CKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVS 138
C G D AN+T VE+ I P +V + I +S
Sbjct: 5361 C----DCGTDKTKANVT-VEARLIKVEKPLYGVEVFVGETAHFEIELS 5403
Score = 44.7 bits (104), Expect = 3e-04
Identities = 50/193 (25%), Positives = 78/193 (40%), Gaps = 26/193 (13%)
Query: 36 CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 95
CE S E + + KWFK+G E+ + K I K L INK L D EY C+V +
Sbjct: 6023 CELSRE--NAKVKWFKDGAEIKKGKK---YDIISKGAVRILVINKCLLDDEAEYSCEVRT 6077
Query: 96 KLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRI--SVSTEGANT---SSSTST 150
S +T++E + T A+ E VS I++ VS GA
Sbjct: 6078 A----RTSGMLTVLEEEAVFTKNLANIE---VSETDTIKLVCEVSKPGAEVIWYKGDEEI 6130
Query: 151 STTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY- 209
TG ++ K N L + Y C+ P+ T + + + +A+ +
Sbjct: 6131 IETGRYEILTEGRKRILVIQNA-------HLEDAGNYNCRLPSSRTDGKVKVHELAAEFI 6183
Query: 210 -KHLGIEFMEAEE 221
K +E +E E+
Sbjct: 6184 SKPQNLEILEGEK 6196
Score = 38.9 bits (89), Expect = 0.014
Identities = 35/162 (21%), Positives = 64/162 (39%), Gaps = 11/162 (6%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFK---WFKNGNELNRKNKPQNIKIQKKP 71
PP++ + E+ SK + + E S LR K W+K+G +L Q
Sbjct: 26345 PPKITQFLKAEA---SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH--YSAD 26399
Query: 72 GKSELRINKASLADSGEYMCKVISKLGNDSASANI---TIVESNEIITGMPASTEGAYVS 128
G EL+IN + +D GEY+C++ + G + +E ++ + + + +
Sbjct: 26400 GTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKT 26459
Query: 129 SESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCV 170
+ES + + SS TG ++ F V
Sbjct: 26460 TESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAV 26501
Score = 37.7 bits (86), Expect = 0.032
Identities = 26/109 (23%), Positives = 45/109 (41%), Gaps = 4/109 (3%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
P + +K+ G + L C S Y S W++ ++ + +I + G +
Sbjct: 897 PTLVSGLKNVTVIEGESVTLECHISG-YPSPTVTWYREDYQIESSI---DFQITFQSGIA 952
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTE 123
L I +A DSG + C +++ G S S + + S E A TE
Sbjct: 953 RLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE 1001
Score = 37.4 bits (85), Expect = 0.042
Identities = 16/60 (26%), Positives = 28/60 (46%)
Query: 49 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
W+K+G ++ + + + G +L IN + D EY +K G DS A +T+
Sbjct: 25351 WYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 25410
Score = 36.2 bits (82), Expect = 0.093
Identities = 20/60 (33%), Positives = 31/60 (51%), Gaps = 3/60 (5%)
Query: 49 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
W K+G + + K K+ + G L I+K +DSG Y C V + G+ S+S +TI
Sbjct: 26513 WTKDGKAITQGGK---YKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 26569
Score = 35.4 bits (80), Expect = 0.16
Identities = 27/116 (23%), Positives = 44/116 (37%), Gaps = 3/116 (2%)
Query: 8 RVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 67
++G P LKE+K A G + E + WFK +L I
Sbjct: 3693 KLGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPT-VTWFKENKQLC--TSVYYTII 3749
Query: 68 QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTE 123
G +N DSG Y+CK + LG + +A + ++ + +T P +
Sbjct: 3750 HNPNGSGTFIVNDPQREDSGLYICKAENMLGESTCAAELLVLLEDTDMTDTPCKAK 3805
Score = 35.4 bits (80), Expect = 0.16
Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 2/43 (4%)
Query: 19 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNK 61
K ++ Q G+ VL CE S E + + KWFKNG E+ + K
Sbjct: 5917 KPLEDQTVEEGATAVLECEVSRE--NAKVKWFKNGTEILKSKK 5957
Score = 35.0 bits (79), Expect = 0.21
Identities = 31/121 (25%), Positives = 53/121 (43%), Gaps = 11/121 (9%)
Query: 11 TTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNI-KIQK 69
T L P +K+ + + AG +VL + + W K G ++ +P +I +I
Sbjct: 14005 TIVLDPTIKDGLTIK--AGDTIVLNAISILGKPLPKSSWSKAGKDI----RPSDITQITS 14058
Query: 70 KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS 129
P S L I A+ D+GEY + G +T+++ + G P E + VS+
Sbjct: 14059 TPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLD----VPGPPGPVEISNVSA 14114
Query: 130 E 130
E
Sbjct: 14115 E 14115
Score = 34.7 bits (78), Expect = 0.27
Identities = 22/107 (20%), Positives = 44/107 (41%), Gaps = 3/107 (2%)
Query: 8 RVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 67
+V + + P ++ G + C+ + S + W+ +L K +I
Sbjct: 25189 KVASIEIGPVSGQIMHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEK---YEI 25245
Query: 68 QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEI 114
+ G + L + + D G Y CKV++ G DS+ A + + E+
Sbjct: 25246 TYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREV 25292
Score = 33.9 bits (76), Expect = 0.46
Identities = 30/123 (24%), Positives = 52/123 (42%), Gaps = 11/123 (8%)
Query: 18 LKEMK----SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 73
+KE+K ++ GS + C S S+ W K+G+ + K + I K
Sbjct: 4746 VKEIKDIILTESEFVGSSAIFECLVSP--STAITTWMKDGSNIRESPKHRFIADGKD--- 4800
Query: 74 SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPI 133
+L I L+D+GEY C + +LGN ++ +V + + E V P+
Sbjct: 4801 RKLHIIDVQLSDAGEYTC--VLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPL 4858
Query: 134 RIS 136
+S
Sbjct: 4859 YLS 4861
Score = 33.5 bits (75), Expect = 0.60
Identities = 26/97 (26%), Positives = 43/97 (44%), Gaps = 2/97 (2%)
Query: 10 GTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK 69
G A P + + Q+ G +V C+ + W K+G L + + K
Sbjct: 1031 GEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVY-WKKSGVPLTTGYR-YKVSYNK 1088
Query: 70 KPGKSELRINKASLADSGEYMCKVISKLGNDSASANI 106
+ G+ +L I+ D+GEY V +K G SASA++
Sbjct: 1089 QTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1125
Score = 32.7 bits (73), Expect = 1.0
Identities = 27/97 (27%), Positives = 44/97 (45%), Gaps = 8/97 (8%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
LK+ + +E ++V CE ++E + KWF+N + +K I +K LR
Sbjct: 6274 LKDTRVKEQ---QEVVFNCEVNTE--GAKAKWFRNEEAIFDSSK---YIILQKDLVYTLR 6325
Query: 78 INKASLADSGEYMCKVISKLGNDSASANITIVESNEI 114
I A L D Y + + G + SA IVE ++
Sbjct: 6326 IRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDL 6362
Score = 32.7 bits (73), Expect = 1.0
Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 5/76 (6%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
++ ++ Q V C+ S E +++ KW++NG E+ K K +K L
Sbjct: 6454 VEHLEDQTVTEFDDAVFSCQLSREKANV--KWYRNGREIKEGKK---YKFEKDGSIHRLI 6508
Query: 78 INKASLADSGEYMCKV 93
I L D EY C V
Sbjct: 6509 IKDCRLDDECEYACGV 6524
Score = 32.7 bits (73), Expect = 1.0
Identities = 16/61 (26%), Positives = 34/61 (55%), Gaps = 3/61 (4%)
Query: 49 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
W K+G E+ ++ + ++ + L + K+ AD+G Y + +KLG+ +AS N+ +
Sbjct: 8048 WHKDGKEVKASDR---LTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKV 8104
Query: 109 V 109
+
Sbjct: 8105 I 8105
Score = 32.0 bits (71), Expect = 1.8
Identities = 23/75 (30%), Positives = 33/75 (44%), Gaps = 5/75 (6%)
Query: 19 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 78
K + Q A + V CE ++ S + +W ++G L N NI+ + K L I
Sbjct: 2578 KPLTDQTVAESQEAVFECEVANPDS--KGEWLRDGKHLPLTN---NIRSESDGHKRRLII 2632
Query: 79 NKASLADSGEYMCKV 93
L D GEY KV
Sbjct: 2633 AATKLDDIGEYTYKV 2647
Score = 32.0 bits (71), Expect = 1.8
Identities = 24/102 (23%), Positives = 46/102 (45%), Gaps = 3/102 (2%)
Query: 8 RVGTTALPPRLKEMKSQESA-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIK 66
+ G +PP+++ + S S G L + C + E + W G +++ + + +
Sbjct: 26949 KAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTP-EVTWSCGGRKIHSQEQGR-FH 27006
Query: 67 IQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
I+ + L I D G Y + ++ G+DSA+ NI I
Sbjct: 27007 IENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 27048
Score = 31.6 bits (70), Expect = 2.3
Identities = 19/72 (26%), Positives = 33/72 (45%), Gaps = 8/72 (11%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
LK++ ++E K + E + Y + +KW KNG E+ +K Q ++ K L
Sbjct: 2929 LKDINAEE-----KDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQ---MRTKKLTHSLN 2980
Query: 78 INKASLADSGEY 89
I D+ +Y
Sbjct: 2981 IRNVHFGDAADY 2992
Score = 30.8 bits (68), Expect = 3.9
Identities = 24/103 (23%), Positives = 44/103 (42%), Gaps = 8/103 (7%)
Query: 48 KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 107
+W +G L N+ +++ + G L A DSG C+ +K G D SA +
Sbjct: 1691 EWLHDGKPLEAANR---LRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLI 1747
Query: 108 IVESNEII--TGMPASTEGAYVSSESPIRISVSTEGANTSSST 148
+ + ++ + +P +G E ++ EGA T +T
Sbjct: 1748 VKDEKSLVEESQLPEGRKGLQRIEELE---RMAHEGALTGVTT 1787
Score = 30.8 bits (68), Expect = 3.9
Identities = 21/96 (21%), Positives = 44/96 (45%), Gaps = 10/96 (10%)
Query: 46 RFKWFKNGNELNRKNKPQNI---KIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSA 102
+ +W KN + + I ++ + K+EL I KA D G Y ++LG+
Sbjct: 9057 KIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFR 9116
Query: 103 SANITIVE-----SNEIITGMPASTEGAYVSSESPI 133
+ ++ + + N +T + A E Y++ ++P+
Sbjct: 9117 NVHVEVYDRPSPPRNLAVTDIKA--ESCYLTWDAPL 9150
Score = 30.0 bits (66), Expect = 6.7
Identities = 22/100 (22%), Positives = 47/100 (47%), Gaps = 12/100 (12%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
LK++ ++E + V E S + ++R KWFKN L + +++ +Q + +
Sbjct: 5563 LKDVTAKEKESA---VFTVELS--HDNIRVKWFKNDQRL---HTTRSVSMQDEGKTHSIT 5614
Query: 78 INKASLADSGEYMCKVISKLGNDSASANITIVESNEIITG 117
S+ D+ + + + S+ A +T++E + TG
Sbjct: 5615 FKDLSIDDTSQIRVEAMGM----SSEAKLTVLEGDPYFTG 5650
Score = 29.6 bits (65), Expect = 8.7
Identities = 14/62 (22%), Positives = 31/62 (50%), Gaps = 1/62 (1%)
Query: 49 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
W K+ + + P+ +KI + S+ + KA +D G+Y+ + G+ A A + +
Sbjct: 11863 WTKDKDATDLTRSPR-VKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNV 11921
Query: 109 VE 110
++
Sbjct: 11922 LD 11923
Score = 29.6 bits (65), Expect = 8.7
Identities = 38/161 (23%), Positives = 60/161 (37%), Gaps = 13/161 (8%)
Query: 3 KGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKP 62
K ++ TT L + +S G C+T E W + G L+ +
Sbjct: 26177 KSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPT-VTWLRKGQVLSTSARH 26235
Query: 63 QNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE---SNEIITGMP 119
Q + KS I+ +D G Y V + G A +TI + + + +T P
Sbjct: 26236 Q---VTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPP 26292
Query: 120 --ASTEGAYVSSE---SPIRISVSTEGANTSSSTSTSTTGT 155
S E S E SP R+ S E ++ + + T T T
Sbjct: 26293 RVKSPEPRVKSPEAVKSPKRVK-SPEPSHPKAVSPTETKPT 26332
>gi|110349715 titin isoform N2-B [Homo sapiens]
Length = 26926
Score = 56.2 bits (134), Expect = 9e-08
Identities = 41/151 (27%), Positives = 76/151 (50%), Gaps = 13/151 (8%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
P + + +SQ G ++ CE S E S +WFKN ++ + N+ I +
Sbjct: 26637 PAFISQPRSQNINEGQNVLFTCEISGEPSP-EIEWFKNNLPISISS---NVSISRSRNVY 26692
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITIV-----ESNEII--TGMPASTEGAYV 127
L I AS++DSG+Y K + G SA+A++ ++ S E++ T S +G++
Sbjct: 26693 SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSF- 26751
Query: 128 SSESPIRISVSTEGANTSSSTSTSTTGTSHL 158
S +++S S + A+ SS +S+S + + +
Sbjct: 26752 -SSQSVQMSASKQEASFSSFSSSSASSMTEM 26781
Score = 49.7 bits (117), Expect = 8e-06
Identities = 30/96 (31%), Positives = 48/96 (50%), Gaps = 4/96 (4%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
A P ++++ E A G CE S ++RF+WFK G E+ +K I+
Sbjct: 4335 AAPVIKRKIEPLEVALGHLAKFTCEIQSA-PNVRFQWFKAGREIYESDK---CSIRSSKY 4390
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
S L I + + D GEY CK ++ G+ S +A +T+
Sbjct: 4391 ISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 4426
Score = 45.4 bits (106), Expect = 2e-04
Identities = 34/108 (31%), Positives = 50/108 (46%), Gaps = 11/108 (10%)
Query: 31 KLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM 90
++ L+CE S + + KWFK+G E+ K I+ + L+I KA L D GEY+
Sbjct: 5182 EITLKCEVSKD---VPVKWFKDGEEIVPSPK---YSIKADGLRRILKIKKADLKDKGEYV 5235
Query: 91 CKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVS 138
C G D AN+T VE+ I P +V + I +S
Sbjct: 5236 C----DCGTDKTKANVT-VEARLIKVEKPLYGVEVFVGETAHFEIELS 5278
Score = 44.7 bits (104), Expect = 3e-04
Identities = 50/193 (25%), Positives = 78/193 (40%), Gaps = 26/193 (13%)
Query: 36 CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 95
CE S E + + KWFK+G E+ + K I K L INK L D EY C+V +
Sbjct: 5898 CELSRE--NAKVKWFKDGAEIKKGKK---YDIISKGAVRILVINKCLLDDEAEYSCEVRT 5952
Query: 96 KLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRI--SVSTEGANT---SSSTST 150
S +T++E + T A+ E VS I++ VS GA
Sbjct: 5953 A----RTSGMLTVLEEEAVFTKNLANIE---VSETDTIKLVCEVSKPGAEVIWYKGDEEI 6005
Query: 151 STTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY- 209
TG ++ K N L + Y C+ P+ T + + + +A+ +
Sbjct: 6006 IETGRYEILTEGRKRILVIQNA-------HLEDAGNYNCRLPSSRTDGKVKVHELAAEFI 6058
Query: 210 -KHLGIEFMEAEE 221
K +E +E E+
Sbjct: 6059 SKPQNLEILEGEK 6071
Score = 38.9 bits (89), Expect = 0.014
Identities = 35/162 (21%), Positives = 64/162 (39%), Gaps = 11/162 (6%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFK---WFKNGNELNRKNKPQNIKIQKKP 71
PP++ + E+ SK + + E S LR K W+K+G +L Q
Sbjct: 26220 PPKITQFLKAEA---SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH--YSAD 26274
Query: 72 GKSELRINKASLADSGEYMCKVISKLGNDSASANI---TIVESNEIITGMPASTEGAYVS 128
G EL+IN + +D GEY+C++ + G + +E ++ + + + +
Sbjct: 26275 GTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKT 26334
Query: 129 SESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCV 170
+ES + + SS TG ++ F V
Sbjct: 26335 TESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAV 26376
Score = 37.7 bits (86), Expect = 0.032
Identities = 26/109 (23%), Positives = 45/109 (41%), Gaps = 4/109 (3%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
P + +K+ G + L C S Y S W++ ++ + +I + G +
Sbjct: 897 PTLVSGLKNVTVIEGESVTLECHISG-YPSPTVTWYREDYQIESSI---DFQITFQSGIA 952
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTE 123
L I +A DSG + C +++ G S S + + S E A TE
Sbjct: 953 RLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE 1001
Score = 37.4 bits (85), Expect = 0.042
Identities = 16/60 (26%), Positives = 28/60 (46%)
Query: 49 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
W+K+G ++ + + + G +L IN + D EY +K G DS A +T+
Sbjct: 25226 WYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 25285
Score = 36.2 bits (82), Expect = 0.093
Identities = 20/60 (33%), Positives = 31/60 (51%), Gaps = 3/60 (5%)
Query: 49 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
W K+G + + K K+ + G L I+K +DSG Y C V + G+ S+S +TI
Sbjct: 26388 WTKDGKAITQGGK---YKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 26444
Score = 35.4 bits (80), Expect = 0.16
Identities = 27/116 (23%), Positives = 44/116 (37%), Gaps = 3/116 (2%)
Query: 8 RVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 67
++G P LKE+K A G + E + WFK +L I
Sbjct: 3568 KLGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPT-VTWFKENKQLC--TSVYYTII 3624
Query: 68 QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTE 123
G +N DSG Y+CK + LG + +A + ++ + +T P +
Sbjct: 3625 HNPNGSGTFIVNDPQREDSGLYICKAENMLGESTCAAELLVLLEDTDMTDTPCKAK 3680
Score = 35.4 bits (80), Expect = 0.16
Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 2/43 (4%)
Query: 19 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNK 61
K ++ Q G+ VL CE S E + + KWFKNG E+ + K
Sbjct: 5792 KPLEDQTVEEGATAVLECEVSRE--NAKVKWFKNGTEILKSKK 5832
Score = 35.0 bits (79), Expect = 0.21
Identities = 31/121 (25%), Positives = 53/121 (43%), Gaps = 11/121 (9%)
Query: 11 TTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNI-KIQK 69
T L P +K+ + + AG +VL + + W K G ++ +P +I +I
Sbjct: 13880 TIVLDPTIKDGLTIK--AGDTIVLNAISILGKPLPKSSWSKAGKDI----RPSDITQITS 13933
Query: 70 KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS 129
P S L I A+ D+GEY + G +T+++ + G P E + VS+
Sbjct: 13934 TPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLD----VPGPPGPVEISNVSA 13989
Query: 130 E 130
E
Sbjct: 13990 E 13990
Score = 34.7 bits (78), Expect = 0.27
Identities = 22/107 (20%), Positives = 44/107 (41%), Gaps = 3/107 (2%)
Query: 8 RVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 67
+V + + P ++ G + C+ + S + W+ +L K +I
Sbjct: 25064 KVASIEIGPVSGQIMHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEK---YEI 25120
Query: 68 QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEI 114
+ G + L + + D G Y CKV++ G DS+ A + + E+
Sbjct: 25121 TYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREV 25167
Score = 33.9 bits (76), Expect = 0.46
Identities = 30/123 (24%), Positives = 52/123 (42%), Gaps = 11/123 (8%)
Query: 18 LKEMK----SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 73
+KE+K ++ GS + C S S+ W K+G+ + K + I K
Sbjct: 4621 VKEIKDIILTESEFVGSSAIFECLVSP--STAITTWMKDGSNIRESPKHRFIADGKD--- 4675
Query: 74 SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPI 133
+L I L+D+GEY C + +LGN ++ +V + + E V P+
Sbjct: 4676 RKLHIIDVQLSDAGEYTC--VLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPL 4733
Query: 134 RIS 136
+S
Sbjct: 4734 YLS 4736
Score = 33.5 bits (75), Expect = 0.60
Identities = 26/97 (26%), Positives = 43/97 (44%), Gaps = 2/97 (2%)
Query: 10 GTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK 69
G A P + + Q+ G +V C+ + W K+G L + + K
Sbjct: 1031 GEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVY-WKKSGVPLTTGYR-YKVSYNK 1088
Query: 70 KPGKSELRINKASLADSGEYMCKVISKLGNDSASANI 106
+ G+ +L I+ D+GEY V +K G SASA++
Sbjct: 1089 QTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1125
Score = 32.7 bits (73), Expect = 1.0
Identities = 27/97 (27%), Positives = 44/97 (45%), Gaps = 8/97 (8%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
LK+ + +E ++V CE ++E + KWF+N + +K I +K LR
Sbjct: 6149 LKDTRVKEQ---QEVVFNCEVNTE--GAKAKWFRNEEAIFDSSK---YIILQKDLVYTLR 6200
Query: 78 INKASLADSGEYMCKVISKLGNDSASANITIVESNEI 114
I A L D Y + + G + SA IVE ++
Sbjct: 6201 IRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDL 6237
Score = 32.7 bits (73), Expect = 1.0
Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 5/76 (6%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
++ ++ Q V C+ S E +++ KW++NG E+ K K +K L
Sbjct: 6329 VEHLEDQTVTEFDDAVFSCQLSREKANV--KWYRNGREIKEGKK---YKFEKDGSIHRLI 6383
Query: 78 INKASLADSGEYMCKV 93
I L D EY C V
Sbjct: 6384 IKDCRLDDECEYACGV 6399
Score = 32.7 bits (73), Expect = 1.0
Identities = 16/61 (26%), Positives = 34/61 (55%), Gaps = 3/61 (4%)
Query: 49 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
W K+G E+ ++ + ++ + L + K+ AD+G Y + +KLG+ +AS N+ +
Sbjct: 7923 WHKDGKEVKASDR---LTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKV 7979
Query: 109 V 109
+
Sbjct: 7980 I 7980
Score = 32.0 bits (71), Expect = 1.8
Identities = 23/75 (30%), Positives = 33/75 (44%), Gaps = 5/75 (6%)
Query: 19 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 78
K + Q A + V CE ++ S + +W ++G L N NI+ + K L I
Sbjct: 2578 KPLTDQTVAESQEAVFECEVANPDS--KGEWLRDGKHLPLTN---NIRSESDGHKRRLII 2632
Query: 79 NKASLADSGEYMCKV 93
L D GEY KV
Sbjct: 2633 AATKLDDIGEYTYKV 2647
Score = 32.0 bits (71), Expect = 1.8
Identities = 24/102 (23%), Positives = 46/102 (45%), Gaps = 3/102 (2%)
Query: 8 RVGTTALPPRLKEMKSQESA-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIK 66
+ G +PP+++ + S S G L + C + E + W G +++ + + +
Sbjct: 26824 KAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTP-EVTWSCGGRKIHSQEQGR-FH 26881
Query: 67 IQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
I+ + L I D G Y + ++ G+DSA+ NI I
Sbjct: 26882 IENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 26923
Score = 31.6 bits (70), Expect = 2.3
Identities = 19/72 (26%), Positives = 33/72 (45%), Gaps = 8/72 (11%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
LK++ ++E K + E + Y + +KW KNG E+ +K Q ++ K L
Sbjct: 2929 LKDINAEE-----KDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQ---MRTKKLTHSLN 2980
Query: 78 INKASLADSGEY 89
I D+ +Y
Sbjct: 2981 IRNVHFGDAADY 2992
Score = 30.8 bits (68), Expect = 3.9
Identities = 24/103 (23%), Positives = 44/103 (42%), Gaps = 8/103 (7%)
Query: 48 KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 107
+W +G L N+ +++ + G L A DSG C+ +K G D SA +
Sbjct: 1691 EWLHDGKPLEAANR---LRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLI 1747
Query: 108 IVESNEII--TGMPASTEGAYVSSESPIRISVSTEGANTSSST 148
+ + ++ + +P +G E ++ EGA T +T
Sbjct: 1748 VKDEKSLVEESQLPEGRKGLQRIEELE---RMAHEGALTGVTT 1787
Score = 30.8 bits (68), Expect = 3.9
Identities = 21/96 (21%), Positives = 44/96 (45%), Gaps = 10/96 (10%)
Query: 46 RFKWFKNGNELNRKNKPQNI---KIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSA 102
+ +W KN + + I ++ + K+EL I KA D G Y ++LG+
Sbjct: 8932 KIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFR 8991
Query: 103 SANITIVE-----SNEIITGMPASTEGAYVSSESPI 133
+ ++ + + N +T + A E Y++ ++P+
Sbjct: 8992 NVHVEVYDRPSPPRNLAVTDIKA--ESCYLTWDAPL 9025
Score = 30.0 bits (66), Expect = 6.7
Identities = 22/100 (22%), Positives = 47/100 (47%), Gaps = 12/100 (12%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
LK++ ++E + V E S + ++R KWFKN L + +++ +Q + +
Sbjct: 5438 LKDVTAKEKESA---VFTVELS--HDNIRVKWFKNDQRL---HTTRSVSMQDEGKTHSIT 5489
Query: 78 INKASLADSGEYMCKVISKLGNDSASANITIVESNEIITG 117
S+ D+ + + + S+ A +T++E + TG
Sbjct: 5490 FKDLSIDDTSQIRVEAMGM----SSEAKLTVLEGDPYFTG 5525
Score = 29.6 bits (65), Expect = 8.7
Identities = 14/62 (22%), Positives = 31/62 (50%), Gaps = 1/62 (1%)
Query: 49 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
W K+ + + P+ +KI + S+ + KA +D G+Y+ + G+ A A + +
Sbjct: 11738 WTKDKDATDLTRSPR-VKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNV 11796
Query: 109 VE 110
++
Sbjct: 11797 LD 11798
Score = 29.6 bits (65), Expect = 8.7
Identities = 38/161 (23%), Positives = 60/161 (37%), Gaps = 13/161 (8%)
Query: 3 KGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKP 62
K ++ TT L + +S G C+T E W + G L+ +
Sbjct: 26052 KSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPT-VTWLRKGQVLSTSARH 26110
Query: 63 QNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE---SNEIITGMP 119
Q + KS I+ +D G Y V + G A +TI + + + +T P
Sbjct: 26111 Q---VTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPP 26167
Query: 120 --ASTEGAYVSSE---SPIRISVSTEGANTSSSTSTSTTGT 155
S E S E SP R+ S E ++ + + T T T
Sbjct: 26168 RVKSPEPRVKSPEAVKSPKRVK-SPEPSHPKAVSPTETKPT 26207
>gi|221316757 neurotrimin isoform 3 [Homo sapiens]
Length = 355
Score = 51.6 bits (122), Expect = 2e-06
Identities = 32/104 (30%), Positives = 50/104 (48%), Gaps = 3/104 (2%)
Query: 11 TTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 70
T PP + E K G K L+CE S+ S F+W+K+ L K +K++ +
Sbjct: 218 TVNYPPYISEAKGTGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK--GVKVENR 274
Query: 71 PGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEI 114
P S+L S D G Y C +KLG+ +AS + V++ +
Sbjct: 275 PFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFEVKTTAL 318
>gi|45594240 limbic system-associated membrane protein [Homo
sapiens]
Length = 338
Score = 51.6 bits (122), Expect = 2e-06
Identities = 28/93 (30%), Positives = 47/93 (50%), Gaps = 4/93 (4%)
Query: 11 TTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 70
T PP + E KS E+ G + L+CE S+ + F+W+++ +N N ++I+
Sbjct: 214 TVNYPPTITESKSNEATTGRQASLKCEASA-VPAPDFEWYRDDTRINSAN---GLEIKST 269
Query: 71 PGKSELRINKASLADSGEYMCKVISKLGNDSAS 103
G+S L + + G Y C +KLG +AS
Sbjct: 270 EGQSSLTVTNVTEEHYGNYTCVAANKLGVTNAS 302
>gi|221316762 neurotrimin isoform 4 [Homo sapiens]
Length = 316
Score = 51.2 bits (121), Expect = 3e-06
Identities = 31/93 (33%), Positives = 45/93 (48%), Gaps = 3/93 (3%)
Query: 11 TTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 70
T PP + E K G K L+CE S+ S F+W+K+ L K +K++ +
Sbjct: 218 TVNYPPYISEAKGTGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK--GVKVENR 274
Query: 71 PGKSELRINKASLADSGEYMCKVISKLGNDSAS 103
P S+L S D G Y C +KLG+ +AS
Sbjct: 275 PFLSKLIFFNVSEHDYGNYTCVASNKLGHTNAS 307
>gi|115298665 neurotrimin isoform 2 [Homo sapiens]
Length = 344
Score = 51.2 bits (121), Expect = 3e-06
Identities = 31/93 (33%), Positives = 45/93 (48%), Gaps = 3/93 (3%)
Query: 11 TTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 70
T PP + E K G K L+CE S+ S F+W+K+ L K +K++ +
Sbjct: 218 TVNYPPYISEAKGTGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK--GVKVENR 274
Query: 71 PGKSELRINKASLADSGEYMCKVISKLGNDSAS 103
P S+L S D G Y C +KLG+ +AS
Sbjct: 275 PFLSKLIFFNVSEHDYGNYTCVASNKLGHTNAS 307
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.125 0.356
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,626,624
Number of Sequences: 37866
Number of extensions: 1262910
Number of successful extensions: 8477
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 119
Number of HSP's successfully gapped in prelim test: 462
Number of HSP's that attempted gapping in prelim test: 6074
Number of HSP's gapped (non-prelim): 2731
length of query: 624
length of database: 18,247,518
effective HSP length: 108
effective length of query: 516
effective length of database: 14,157,990
effective search space: 7305522840
effective search space used: 7305522840
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.