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Search of human proteins with 236460050
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|236460050 elastase 3A, pancreatic preproprotein [Homo
sapiens]
(270 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|236460050 elastase 3A, pancreatic preproprotein [Homo sapiens] 576 e-165
gi|6679625 elastase 3B, pancreatic preproprotein [Homo sapiens] 530 e-151
gi|15559207 elastase 2A preproprotein [Homo sapiens] 312 2e-85
gi|58331211 elastase 2B preproprotein [Homo sapiens] 305 4e-83
gi|62526043 chymotrypsin C preproprotein [Homo sapiens] 288 5e-78
gi|58331209 chymotrypsin-like elastase family, member 1 [Homo sa... 278 5e-75
gi|118498341 chymotrypsin B1 [Homo sapiens] 186 2e-47
gi|118498350 chymotrypsin B2 [Homo sapiens] 184 9e-47
gi|4503137 chymotrypsin-like [Homo sapiens] 182 3e-46
gi|110815798 ovochymase 1 [Homo sapiens] 155 4e-38
gi|4505881 plasminogen [Homo sapiens] 153 1e-37
gi|68508970 tryptase beta 2 precursor [Homo sapiens] 152 4e-37
gi|13775595 tryptase alpha/beta 1 precursor [Homo sapiens] 151 5e-37
gi|11545839 protease, serine, 22 [Homo sapiens] 151 7e-37
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap... 147 7e-36
gi|33695155 hepsin [Homo sapiens] 143 1e-34
gi|4504481 hepsin [Homo sapiens] 143 1e-34
gi|117956391 protease, serine, 33 [Homo sapiens] 141 7e-34
gi|116292750 lipoprotein Lp(a) precursor [Homo sapiens] 138 4e-33
gi|194018492 transmembrane protease, serine 11F [Homo sapiens] 138 4e-33
gi|4506145 protease, serine, 1 preproprotein [Homo sapiens] 138 6e-33
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa... 136 2e-32
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa... 136 2e-32
gi|58218970 protease, serine, 36 [Homo sapiens] 135 3e-32
gi|148231605 ovochymase 2 [Homo sapiens] 135 3e-32
gi|29244926 corin [Homo sapiens] 134 8e-32
gi|4506147 protease, serine, 2 preproprotein [Homo sapiens] 134 1e-31
gi|4506153 prostasin preproprotein [Homo sapiens] 133 1e-31
gi|156938340 transmembrane tryptase preproprotein [Homo sapiens] 133 1e-31
gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens] 133 2e-31
>gi|236460050 elastase 3A, pancreatic preproprotein [Homo sapiens]
Length = 270
Score = 576 bits (1485), Expect = e-165
Identities = 270/270 (100%), Positives = 270/270 (100%)
Query: 1 MMLRLLSSLLLVAVASGYGPPSSHSSSRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCGG 60
MMLRLLSSLLLVAVASGYGPPSSHSSSRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCGG
Sbjct: 1 MMLRLLSSLLLVAVASGYGPPSSHSSSRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCGG 60
Query: 61 SLIAPDWVVTAGHCISRDLTYQVVLGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCVAC 120
SLIAPDWVVTAGHCISRDLTYQVVLGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCVAC
Sbjct: 61 SLIAPDWVVTAGHCISRDLTYQVVLGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCVAC 120
Query: 121 GNDIALIKLSRSAQLGDAVQLASLPPAGDILPNKTPCYITGWGRLYTNGPLPDKLQQARL 180
GNDIALIKLSRSAQLGDAVQLASLPPAGDILPNKTPCYITGWGRLYTNGPLPDKLQQARL
Sbjct: 121 GNDIALIKLSRSAQLGDAVQLASLPPAGDILPNKTPCYITGWGRLYTNGPLPDKLQQARL 180
Query: 181 PVVDYKHCSRWNWWGSTVKKTMVCAGGYIRSGCNGDSGGPLNCPTEDGGWQVHGVTSFVS 240
PVVDYKHCSRWNWWGSTVKKTMVCAGGYIRSGCNGDSGGPLNCPTEDGGWQVHGVTSFVS
Sbjct: 181 PVVDYKHCSRWNWWGSTVKKTMVCAGGYIRSGCNGDSGGPLNCPTEDGGWQVHGVTSFVS 240
Query: 241 AFGCNFIWKPTVFTRVSAFIDWIEETIASH 270
AFGCNFIWKPTVFTRVSAFIDWIEETIASH
Sbjct: 241 AFGCNFIWKPTVFTRVSAFIDWIEETIASH 270
>gi|6679625 elastase 3B, pancreatic preproprotein [Homo sapiens]
Length = 270
Score = 530 bits (1365), Expect = e-151
Identities = 251/270 (92%), Positives = 258/270 (95%)
Query: 1 MMLRLLSSLLLVAVASGYGPPSSHSSSRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCGG 60
MMLRLLSSLLLVAVASGYGPPSS SSRVV+GEDAVPYSWPWQVSLQYEKSGSFYHTCGG
Sbjct: 1 MMLRLLSSLLLVAVASGYGPPSSRPSSRVVNGEDAVPYSWPWQVSLQYEKSGSFYHTCGG 60
Query: 61 SLIAPDWVVTAGHCISRDLTYQVVLGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCVAC 120
SLIAPDWVVTAGHCIS TYQVVLGEY+ AVKEGPEQVIPINS +LFVHPLWNRSCVAC
Sbjct: 61 SLIAPDWVVTAGHCISSSRTYQVVLGEYDRAVKEGPEQVIPINSGDLFVHPLWNRSCVAC 120
Query: 121 GNDIALIKLSRSAQLGDAVQLASLPPAGDILPNKTPCYITGWGRLYTNGPLPDKLQQARL 180
GNDIALIKLSRSAQLGDAVQLASLPPAGDILPN+TPCYITGWGRLYTNGPLPDKLQ+A L
Sbjct: 121 GNDIALIKLSRSAQLGDAVQLASLPPAGDILPNETPCYITGWGRLYTNGPLPDKLQEALL 180
Query: 181 PVVDYKHCSRWNWWGSTVKKTMVCAGGYIRSGCNGDSGGPLNCPTEDGGWQVHGVTSFVS 240
PVVDY+HCSRWNWWGS+VKKTMVCAGG IRSGCNGDSGGPLNCPTEDGGWQVHGVTSFVS
Sbjct: 181 PVVDYEHCSRWNWWGSSVKKTMVCAGGDIRSGCNGDSGGPLNCPTEDGGWQVHGVTSFVS 240
Query: 241 AFGCNFIWKPTVFTRVSAFIDWIEETIASH 270
AFGCN KPTVFTRVSAFIDWIEETIASH
Sbjct: 241 AFGCNTRRKPTVFTRVSAFIDWIEETIASH 270
>gi|15559207 elastase 2A preproprotein [Homo sapiens]
Length = 269
Score = 312 bits (800), Expect = 2e-85
Identities = 155/271 (57%), Positives = 187/271 (69%), Gaps = 4/271 (1%)
Query: 2 MLRLLSSLLLVAVASGYGPPSSHSS-SRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCGG 60
M+R L LVA A G P+ +RVV GE+A P SWPWQVSLQY +G +YHTCGG
Sbjct: 1 MIRTLLLSTLVAGALSCGDPTYPPYVTRVVGGEEARPNSWPWQVSLQYSSNGKWYHTCGG 60
Query: 61 SLIAPDWVVTAGHCISRDLTYQVVLGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCVAC 120
SLIA WV+TA HCIS TY+V LG +NL V E + ++ ++ VH WN + ++
Sbjct: 61 SLIANSWVLTAAHCISSSRTYRVGLGRHNLYVAESGSLAVSVS--KIVVHKDWNSNQISK 118
Query: 121 GNDIALIKLSRSAQLGDAVQLASLPPAGDILPNKTPCYITGWGRLYTNGPLPDKLQQARL 180
GNDIAL+KL+ L D +QLA LPPAG ILPN PCY+TGWGRL TNG +PD LQQ RL
Sbjct: 119 GNDIALLKLANPVSLTDKIQLACLPPAGTILPNNYPCYVTGWGRLQTNGAVPDVLQQGRL 178
Query: 181 PVVDYKHCSRWNWWGSTVKKTMVCAGG-YIRSGCNGDSGGPLNCPTEDGGWQVHGVTSFV 239
VVDY CS WWGS+VK +M+CAGG + S CNGDSGGPLNC DG WQVHG+ SF
Sbjct: 179 LVVDYATCSSSAWWGSSVKTSMICAGGDGVISSCNGDSGGPLNCQASDGRWQVHGIVSFG 238
Query: 240 SAFGCNFIWKPTVFTRVSAFIDWIEETIASH 270
S GCN+ KP+VFTRVS +IDWI IA++
Sbjct: 239 SRLGCNYYHKPSVFTRVSNYIDWINSVIANN 269
>gi|58331211 elastase 2B preproprotein [Homo sapiens]
Length = 269
Score = 305 bits (780), Expect = 4e-83
Identities = 149/270 (55%), Positives = 185/270 (68%), Gaps = 10/270 (3%)
Query: 5 LLSSLLLVAVASG---YGPPSSHSSSRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCGGS 61
LLS+L+ A++ G Y P SR++ GE+A P SWPWQVSLQY +G +YHTCGGS
Sbjct: 6 LLSTLVAGALSCGVSTYAP----DMSRMLGGEEARPNSWPWQVSLQYSSNGQWYHTCGGS 61
Query: 62 LIAPDWVVTAGHCISRDLTYQVVLGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCVACG 121
LIA WV+TA HCIS Y+V+LG++NL V E + ++ ++ VH WN V+ G
Sbjct: 62 LIANSWVLTAAHCISSSGIYRVMLGQHNLYVAESGSLAVSVS--KIVVHKDWNSDQVSKG 119
Query: 122 NDIALIKLSRSAQLGDAVQLASLPPAGDILPNKTPCYITGWGRLYTNGPLPDKLQQARLP 181
NDIAL+KL+ L D +QLA LPPAG ILPN PCY+TGWGRL TNG LPD L+Q RL
Sbjct: 120 NDIALLKLANPVSLTDKIQLACLPPAGTILPNNYPCYVTGWGRLQTNGALPDDLKQGRLL 179
Query: 182 VVDYKHCSRWNWWGSTVKKTMVCAGG-YIRSGCNGDSGGPLNCPTEDGGWQVHGVTSFVS 240
VVDY CS WWGSTVK M+CAGG + CNGDSGGPLNC DG W+VHG+ S S
Sbjct: 180 VVDYATCSSSGWWGSTVKTNMICAGGDGVICTCNGDSGGPLNCQASDGRWEVHGIGSLTS 239
Query: 241 AFGCNFIWKPTVFTRVSAFIDWIEETIASH 270
GCN+ +KP++FTRVS + DWI IA++
Sbjct: 240 VLGCNYYYKPSIFTRVSNYNDWINSVIANN 269
>gi|62526043 chymotrypsin C preproprotein [Homo sapiens]
Length = 268
Score = 288 bits (736), Expect = 5e-78
Identities = 146/267 (54%), Positives = 183/267 (68%), Gaps = 6/267 (2%)
Query: 2 MLRLLSSLLLVAVASGYGPPS--SHSSSRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCG 59
ML + L+A AS G PS + S+RVV GEDA P+SWPWQ+SLQY K+ ++ HTCG
Sbjct: 1 MLGITVLAALLACASSCGVPSFPPNLSARVVGGEDARPHSWPWQISLQYLKNDTWRHTCG 60
Query: 60 GSLIAPDWVVTAGHCISRDLTYQVVLGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCVA 119
G+LIA ++V+TA HCIS TY+V +G+ NL V E E + + + + VH WN +
Sbjct: 61 GTLIASNFVLTAAHCISNTRTYRVAVGKNNLEV-EDEEGSLFVGVDTIHVHKRWN--ALL 117
Query: 120 CGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNKTPCYITGWGRLYTNGPLPDKLQQAR 179
NDIALIKL+ +L D +Q+A LP +LP PCY+TGWGRL+TNGP+ DKLQQ
Sbjct: 118 LRNDIALIKLAEHVELSDTIQVACLPEKDSLLPKDYPCYVTGWGRLWTNGPIADKLQQGL 177
Query: 180 LPVVDYKHCSRWNWWGSTVKKTMVCAGG-YIRSGCNGDSGGPLNCPTEDGGWQVHGVTSF 238
PVVD+ CSR +WWG VKKTMVCAGG + S CNGDSGGPLNC E+G W+V G+ SF
Sbjct: 178 QPVVDHATCSRIDWWGFRVKKTMVCAGGDGVISACNGDSGGPLNCQLENGSWEVFGIVSF 237
Query: 239 VSAFGCNFIWKPTVFTRVSAFIDWIEE 265
S GCN KP V+TRVSA+IDWI E
Sbjct: 238 GSRRGCNTRKKPVVYTRVSAYIDWINE 264
>gi|58331209 chymotrypsin-like elastase family, member 1 [Homo
sapiens]
Length = 258
Score = 278 bits (710), Expect = 5e-75
Identities = 138/247 (55%), Positives = 174/247 (70%), Gaps = 4/247 (1%)
Query: 25 SSSRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLIAPDWVVTAGHCISRDLTYQVV 84
+++RVV G +A SWP Q+SLQY GS YHTCGG+LI +WV+TA HC+ T++VV
Sbjct: 15 TNARVVGGTEAGRNSWPSQISLQYRSGGSRYHTCGGTLIRQNWVMTAAHCVDYQKTFRVV 74
Query: 85 LGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCVACGNDIALIKLSRSAQLGDAVQLASL 144
G++NL+ +G EQ + + +++ VHP WN VA G DIAL++L++S L VQL L
Sbjct: 75 AGDHNLSQNDGTEQYVSV--QKIVVHPYWNSDNVAAGYDIALLRLAQSVTLNSYVQLGVL 132
Query: 145 PPAGDILPNKTPCYITGWGRLYTNGPLPDKLQQARLPVVDYKHCSRWNWWGSTVKKTMVC 204
P G IL N +PCYITGWG+ TNG L LQQA LP VDY CS ++WGSTVK TMVC
Sbjct: 133 PQEGAILANNSPCYITGWGKTKTNGQLAQTLQQAYLPSVDYAICSSSSYWGSTVKNTMVC 192
Query: 205 AGG-YIRSGCNGDSGGPLNCPTEDGGWQVHGVTSFVSAFGCNFIWKPTVFTRVSAFIDWI 263
AGG +RSGC GDSGGPL+C +G + VHGVTSFVS+ GCN KPTVFT+VSA+I WI
Sbjct: 193 AGGDGVRSGCQGDSGGPLHC-LVNGKYSVHGVTSFVSSRGCNVSRKPTVFTQVSAYISWI 251
Query: 264 EETIASH 270
IAS+
Sbjct: 252 NNVIASN 258
>gi|118498341 chymotrypsin B1 [Homo sapiens]
Length = 263
Score = 186 bits (471), Expect = 2e-47
Identities = 118/273 (43%), Positives = 156/273 (57%), Gaps = 18/273 (6%)
Query: 3 LRLLSSLLLVAVASGYGPPSSH----SSSRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTC 58
L LLS LV A G G P+ H SR+V+GEDAVP SWPWQVSLQ +K+G +H C
Sbjct: 4 LWLLSCFSLVGAAFGCGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQ-DKTG--FHFC 60
Query: 59 GGSLIAPDWVVTAGHCISRDLTYQVVLGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCV 118
GGSLI+ DWVVTA HC R + VV GE++ E QV+ I ++F +P + S +
Sbjct: 61 GGSLISEDWVVTAAHCGVR-TSDVVVAGEFDQGSDEENIQVLKI--AKVFKNPKF--SIL 115
Query: 119 ACGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNKTPCYITGWGRL-YTNGPLPDKLQQ 177
NDI L+KL+ A+ V LP A D P T C TGWG+ Y PDKLQQ
Sbjct: 116 TVNNDITLLKLATPARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQ 175
Query: 178 ARLPVVDYKHCSRWNWWGSTVKKTMVCAGGYIRSGCNGDSGGPLNCPTEDGGWQVHGVTS 237
A LP++ C + WG + M+CAG S C GDSGGPL C +DG W + G+ S
Sbjct: 176 AALPLLSNAECKK--SWGRRITDVMICAGASGVSSCMGDSGGPLVC-QKDGAWTLVGIVS 232
Query: 238 FVSAFGCNFIWKPTVFTRVSAFIDWIEETIASH 270
+ S C+ P V+ RV+ I W+++ +A++
Sbjct: 233 WGSD-TCS-TSSPGVYARVTKLIPWVQKILAAN 263
>gi|118498350 chymotrypsin B2 [Homo sapiens]
Length = 263
Score = 184 bits (466), Expect = 9e-47
Identities = 116/273 (42%), Positives = 155/273 (56%), Gaps = 18/273 (6%)
Query: 3 LRLLSSLLLVAVASGYGPPSSH----SSSRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTC 58
L LLS L+ G G P+ H SR+V+GEDAVP SWPWQVSLQ +K+G +H C
Sbjct: 4 LWLLSCWALLGTTFGCGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQ-DKTG--FHFC 60
Query: 59 GGSLIAPDWVVTAGHCISRDLTYQVVLGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCV 118
GGSLI+ DWVVTA HC R + VV GE++ E QV+ I ++F +P + S +
Sbjct: 61 GGSLISEDWVVTAAHCGVR-TSDVVVAGEFDQGSDEENIQVLKI--AKVFKNPKF--SIL 115
Query: 119 ACGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNKTPCYITGWGRL-YTNGPLPDKLQQ 177
NDI L+KL+ A+ V LP A D P T C TGWG+ Y PDKLQQ
Sbjct: 116 TVNNDITLLKLATPARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQ 175
Query: 178 ARLPVVDYKHCSRWNWWGSTVKKTMVCAGGYIRSGCNGDSGGPLNCPTEDGGWQVHGVTS 237
A LP++ C + WG + M+CAG S C GDSGGPL C +DG W + G+ S
Sbjct: 176 AALPLLSNAECKK--SWGRRITDVMICAGASGVSSCMGDSGGPLVC-QKDGAWTLVGIVS 232
Query: 238 FVSAFGCNFIWKPTVFTRVSAFIDWIEETIASH 270
+ S C+ P V+ RV+ I W+++ +A++
Sbjct: 233 WGSR-TCS-TTTPAVYARVAKLIPWVQKILAAN 263
>gi|4503137 chymotrypsin-like [Homo sapiens]
Length = 264
Score = 182 bits (462), Expect = 3e-46
Identities = 112/274 (40%), Positives = 150/274 (54%), Gaps = 19/274 (6%)
Query: 2 MLRLLSSLLLVAVASGYG------PPSSHSSSRVVHGEDAVPYSWPWQVSLQYEKSGSFY 55
ML L +L LV + S +G P+ S R+V+GE+AV SWPWQVSLQ S +
Sbjct: 1 MLLLSLTLSLVLLGSSWGCGIPAIKPALSFSQRIVNGENAVLGSWPWQVSLQ---DSSGF 57
Query: 56 HTCGGSLIAPDWVVTAGHCISRDLTYQVVLGEYNLAVKEGPEQVIPINSEELFVHPLWNR 115
H CGGSLI+ WVVTA HC + VVLGEY+ + P QV+ ++ HP WN
Sbjct: 58 HFCGGSLISQSWVVTAAHCNVSPGRHFVVLGEYDRSSNAEPLQVLSVS--RAITHPSWNS 115
Query: 116 SCVACGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNKTPCYITGWGRLYTNGPL-PDK 174
+ + ND+ L+KL+ AQ + L + + L C TGWGRL G + P
Sbjct: 116 TTM--NNDVTLLKLASPAQYTTRISPVCLASSNEALTEGLTCVTTGWGRLSGVGNVTPAH 173
Query: 175 LQQARLPVVDYKHCSRWNWWGSTVKKTMVCAGGYIRSGCNGDSGGPLNCPTEDGGWQVHG 234
LQQ LP+V C + +WGS++ +M+CAGG S C GDSGGPL C + W + G
Sbjct: 174 LQQVALPLVTVNQCRQ--YWGSSITDSMICAGGAGASSCQGDSGGPLVC-QKGNTWVLIG 230
Query: 235 VTSFVSAFGCNFIWKPTVFTRVSAFIDWIEETIA 268
+ S+ CN + P V+TRVS F WI + IA
Sbjct: 231 IVSW-GTKNCN-VRAPAVYTRVSKFSTWINQVIA 262
>gi|110815798 ovochymase 1 [Homo sapiens]
Length = 1134
Score = 155 bits (392), Expect = 4e-38
Identities = 91/259 (35%), Positives = 147/259 (56%), Gaps = 22/259 (8%)
Query: 20 PPSSHS--SSRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLIAPDWVVTAGHCI-- 75
PP S S R+ GE+A P+ WPWQV L++ + CGG++I P W++TA HC+
Sbjct: 564 PPFSPQWLSRRIAGGEEACPHCWPWQVGLRFLGD----YQCGGAIINPVWILTAAHCVQL 619
Query: 76 -SRDLTYQVVLGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCVACGNDIALIKLSRSAQ 134
+ L++ ++ G+++ +KE EQV ++ + VH +N ++ +DIALI+LS +
Sbjct: 620 KNNPLSWTIIAGDHDRNLKESTEQVR--RAKHIIVHEDFNT--LSYDSDIALIQLSSPLE 675
Query: 135 LGDAVQLASLPPAGDILPNKTPCYITGWGRLYTNGPLPDKLQQARLPVVDYKHCSR--WN 192
V+ LP + + L + C +TGWG + +G L +LQQ ++ V++ + C ++
Sbjct: 676 YNSVVRPVCLPHSAEPLFSSEICAVTGWGSISADGGLASRLQQIQVHVLEREVCEHTYYS 735
Query: 193 WWGSTVKKTMVCAGGYIRSG----CNGDSGGPLNCPTEDGGWQVHGVTSFVSAFGCNFIW 248
+ + M+CA G+ SG C GDSGGPL C E+G + ++G+ S+ GC W
Sbjct: 736 AHPGGITEKMICA-GFAASGEKDFCQGDSGGPLVCRHENGPFVLYGIVSW--GAGCVQPW 792
Query: 249 KPTVFTRVSAFIDWIEETI 267
KP VF RV F+DWI+ I
Sbjct: 793 KPGVFARVMIFLDWIQSKI 811
Score = 122 bits (307), Expect = 3e-28
Identities = 92/284 (32%), Positives = 140/284 (49%), Gaps = 28/284 (9%)
Query: 3 LRLLSSLLLVAVASGYGPPSSHSSSRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSL 62
L L + +V + S S SR+ ++ PWQVSL+ ++ +H CGGSL
Sbjct: 21 LGLKCGIRMVNMKSKEPAVGSRFFSRISSWRNSTVTGHPWQVSLKSDE----HHFCGGSL 76
Query: 63 IAPDWVVTAGHCISRDLTYQ-----VVLGEYNLAVKEGPEQVIPINSEELFVHPLWNRSC 117
I D VVTA HC+ Q V GEY+L K+ EQ IP++ ++ HP +N S
Sbjct: 77 IQEDRVVTAAHCLDSLSEKQLKNITVTSGEYSLFQKDKQEQNIPVS--KIITHPEYN-SR 133
Query: 118 VACGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNKTPCYITGWGRLYTNGPLPDKLQQ 177
DIAL+ L + G+AVQ LP + D + C +GWG++ + LQ+
Sbjct: 134 EYMSPDIALLYLKHKVKFGNAVQPICLPDSDDKVEPGILCLSSGWGKISKTSEYSNVLQE 193
Query: 178 ARLPVVDYKHCSR--WNWWGSTVKKTMVCAG--GYIRSGCNGDSGGPLNCPTEDGGWQVH 233
LP++D + C+ + + +TM+CAG + C GDSGGPL C G W +
Sbjct: 194 MELPIMDDRACNTVLKSMNLPPLGRTMLCAGFPDWGMDACQGDSGGPLVCRRGGGIWILA 253
Query: 234 GVTSFVSAFGCNFIWKPT----------VFTRVSAFIDWIEETI 267
G+TS+V+ GC P +F++VS +D+I + +
Sbjct: 254 GITSWVA--GCAGGSVPVRNNHVKASLGIFSKVSELMDFITQNL 295
>gi|4505881 plasminogen [Homo sapiens]
Length = 810
Score = 153 bits (387), Expect = 1e-37
Identities = 100/244 (40%), Positives = 139/244 (56%), Gaps = 26/244 (10%)
Query: 28 RVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLIAPDWVVTAGHCIS---RDLTYQVV 84
RVV G A P+SWPWQVSL+ H CGG+LI+P+WV+TA HC+ R +Y+V+
Sbjct: 580 RVVGGCVAHPHSWPWQVSLRTRFG---MHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVI 636
Query: 85 LGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCVACGNDIALIKLSRSAQLGDAVQLASL 144
LG + E Q I ++ LF+ P DIAL+KLS A + D V A L
Sbjct: 637 LGAHQEVNLEPHVQEIEVS--RLFLEPT--------RKDIALLKLSSPAVITDKVIPACL 686
Query: 145 PPAGDILPNKTPCYITGWGRLYTNGPL-PDKLQQARLPVVDYKHCSRWNWWGSTVKKTMV 203
P ++ ++T C+ITGWG T G L++A+LPV++ K C+R+ + V+ T +
Sbjct: 687 PSPNYVVADRTECFITGWGE--TQGTFGAGLLKEAQLPVIENKVCNRYEFLNGRVQSTEL 744
Query: 204 CAGGYIRSG---CNGDSGGPLNCPTEDGGWQVHGVTSFVSAFGCNFIWKPTVFTRVSAFI 260
CA G++ G C GDSGGPL C +D + + GVTS+ GC KP V+ RVS F+
Sbjct: 745 CA-GHLAGGTDSCQGDSGGPLVCFEKD-KYILQGVTSW--GLGCARPNKPGVYVRVSRFV 800
Query: 261 DWIE 264
WIE
Sbjct: 801 TWIE 804
>gi|68508970 tryptase beta 2 precursor [Homo sapiens]
Length = 275
Score = 152 bits (383), Expect = 4e-37
Identities = 96/282 (34%), Positives = 148/282 (52%), Gaps = 27/282 (9%)
Query: 2 MLRLLSSLLLVAVASGYGPPSSHSSSR---VVHGEDAVPYSWPWQVSLQYEKSGSFYHTC 58
ML LL L V + Y P+ + + +V G++A WPWQVSL+ + + H C
Sbjct: 1 MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRV-RDRYWMHFC 59
Query: 59 GGSLIAPDWVVTAGHCISRDL----TYQVVLGEYNLAVKEGPEQVIPINSEELFVHPLWN 114
GGSLI P WV+TA HC+ D+ +V L E +L ++ Q++P++ + VHP +
Sbjct: 60 GGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQD---QLLPVS--RIIVHPQFY 114
Query: 115 RSCVACGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNKTPCYITGWGRLYTNG--PLP 172
+ + G DIAL++L + V +LPPA + P PC++TGWG + + P P
Sbjct: 115 TAQI--GADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPP 172
Query: 173 DKLQQARLPVVDYKHCSRWNWWGS-------TVKKTMVCAGGYIRSGCNGDSGGPLNCPT 225
L+Q ++P+++ C G+ V+ M+CAG R C GDSGGPL C
Sbjct: 173 FPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKV 232
Query: 226 EDGGWQVHGVTSFVSAFGCNFIWKPTVFTRVSAFIDWIEETI 267
+G W GV S+ GC +P ++TRV+ ++DWI +
Sbjct: 233 -NGTWLQAGVVSW--GEGCAQPNRPGIYTRVTYYLDWIHHYV 271
>gi|13775595 tryptase alpha/beta 1 precursor [Homo sapiens]
Length = 275
Score = 151 bits (382), Expect = 5e-37
Identities = 97/283 (34%), Positives = 149/283 (52%), Gaps = 29/283 (10%)
Query: 2 MLRLLSSLLLVAVASGYGPPSSHSSSR---VVHGEDAVPYSWPWQVSLQYEKSGSFY-HT 57
ML LL L V + Y P+ + + +V G++A WPWQVSL+ G ++ H
Sbjct: 1 MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVH--GPYWMHF 58
Query: 58 CGGSLIAPDWVVTAGHCISRDL----TYQVVLGEYNLAVKEGPEQVIPINSEELFVHPLW 113
CGGSLI P WV+TA HC+ D+ +V L E +L ++ Q++P++ + VHP +
Sbjct: 59 CGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQD---QLLPVS--RIIVHPQF 113
Query: 114 NRSCVACGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNKTPCYITGWGRLYTNG--PL 171
+ + G DIAL++L + V +LPPA + P PC++TGWG + + P
Sbjct: 114 YTAQI--GADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPP 171
Query: 172 PDKLQQARLPVVDYKHCSRWNWWGS-------TVKKTMVCAGGYIRSGCNGDSGGPLNCP 224
P L+Q ++P+++ C G+ V+ M+CAG R C GDSGGPL C
Sbjct: 172 PFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCK 231
Query: 225 TEDGGWQVHGVTSFVSAFGCNFIWKPTVFTRVSAFIDWIEETI 267
+G W GV S+ GC +P ++TRV+ ++DWI +
Sbjct: 232 V-NGTWLQAGVVSW--GEGCAQPNRPGIYTRVTYYLDWIHHYV 271
>gi|11545839 protease, serine, 22 [Homo sapiens]
Length = 317
Score = 151 bits (381), Expect = 7e-37
Identities = 102/280 (36%), Positives = 148/280 (52%), Gaps = 26/280 (9%)
Query: 3 LRLLSSLLLVAVASGYGPPSS---HSSSRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCG 59
L LL+S ++ A PP+ +RVV GED+ WPW VS+Q K+G+ H C
Sbjct: 21 LLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSEWPWIVSIQ--KNGT--HHCA 76
Query: 60 GSLIAPDWVVTAGHCISRDLT----YQVVLGEYNLAVKEGPEQVIPINSEELFVHPLWNR 115
GSL+ WV+TA HC +L + V+LG + L Q + + E HP+++
Sbjct: 77 GSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQKVGVAWVE--PHPVYSW 134
Query: 116 SCVACGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNKTPCYITGWGRLYTNGPL--PD 173
AC DIAL++L RS Q + V LP A LP T C+I+GWG + PL P
Sbjct: 135 KEGACA-DIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQ 193
Query: 174 KLQQARLPVVDYKHCSRWNWWGS---TVKKTMVCAGGYI---RSGCNGDSGGPLNCPTED 227
LQ+ ++P++D + CS W G+ + + M+CA GY+ R C GDSGGPL C D
Sbjct: 194 TLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCA-GYLEGERDACLGDSGGPLMCQV-D 251
Query: 228 GGWQVHGVTSFVSAFGCNFIWKPTVFTRVSAFIDWIEETI 267
G W + G+ S+ GC +P V+ +SA W+E+ +
Sbjct: 252 GAWLLAGIISW--GEGCAERNRPGVYISLSAHRSWVEKIV 289
>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
sapiens]
Length = 454
Score = 147 bits (372), Expect = 7e-36
Identities = 89/248 (35%), Positives = 134/248 (54%), Gaps = 23/248 (9%)
Query: 26 SSRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLIAPDWVVTAGHCISRDL----TY 81
SSR+V G ++ WPWQ SLQ++ YH CGGS+I P W++TA HC+ DL ++
Sbjct: 214 SSRIVGGNMSLLSQWPWQASLQFQG----YHLCGGSVITPLWIITAAHCV-YDLYLPKSW 268
Query: 82 QVVLGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCVACGNDIALIKLSRSAQLGDAVQL 141
+ +G +L P ++ E++ H + GNDIAL+KL+ + +Q
Sbjct: 269 TIQVGLVSLLDNPAPSHLV----EKIVYHSKYKPK--RLGNDIALMKLAGPLTFNEMIQP 322
Query: 142 ASLPPAGDILPNKTPCYITGWGRLYTN-GPLPDKLQQARLPVVDYKHCSRWNWWGSTVKK 200
LP + + P+ C+ +GWG G L A +P++ K C+ + +G +
Sbjct: 323 VCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISP 382
Query: 201 TMVCAGGYIRSG---CNGDSGGPLNCPTEDGGWQVHGVTSFVSAFGCNFIWKPTVFTRVS 257
+M+CA GY+ G C GDSGGPL C E W++ G TSF GC + KP V+TRV+
Sbjct: 383 SMLCA-GYLTGGVDSCQGDSGGPLVC-QERRLWKLVGATSF--GIGCAEVNKPGVYTRVT 438
Query: 258 AFIDWIEE 265
+F+DWI E
Sbjct: 439 SFLDWIHE 446
>gi|33695155 hepsin [Homo sapiens]
Length = 417
Score = 143 bits (361), Expect = 1e-34
Identities = 91/257 (35%), Positives = 134/257 (52%), Gaps = 25/257 (9%)
Query: 28 RVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLIAPDWVVTAGHCI---SRDLT-YQV 83
R+V G D WPWQVSL+Y+ + H CGGSL++ DWV+TA HC +R L+ ++V
Sbjct: 162 RIVGGRDTSLGRWPWQVSLRYDGA----HLCGGSLLSGDWVLTAAHCFPERNRVLSRWRV 217
Query: 84 VLGEYNLAVKEGPEQVIPINSEELFVH----PLWNRSCVACGNDIALIKLSRSAQLGDAV 139
G AV + + + + + H P + + NDIAL+ LS L + +
Sbjct: 218 FAG----AVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYI 273
Query: 140 QLASLPPAGDILPNKTPCYITGWGRLYTNGPLPDKLQQARLPVVDYKHCSRWNWWGSTVK 199
Q LP AG L + C +TGWG G LQ+AR+P++ C+ +++G+ +K
Sbjct: 274 QPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIK 333
Query: 200 KTMVCAGGYIRSG---CNGDSGGPLNCP---TEDGGWQVHGVTSFVSAFGCNFIWKPTVF 253
M CA GY G C GDSGGP C + W++ G+ S+ GC KP V+
Sbjct: 334 PKMFCA-GYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSW--GTGCALAQKPGVY 390
Query: 254 TRVSAFIDWIEETIASH 270
T+VS F +WI + I +H
Sbjct: 391 TKVSDFREWIFQAIKTH 407
>gi|4504481 hepsin [Homo sapiens]
Length = 417
Score = 143 bits (361), Expect = 1e-34
Identities = 91/257 (35%), Positives = 134/257 (52%), Gaps = 25/257 (9%)
Query: 28 RVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLIAPDWVVTAGHCI---SRDLT-YQV 83
R+V G D WPWQVSL+Y+ + H CGGSL++ DWV+TA HC +R L+ ++V
Sbjct: 162 RIVGGRDTSLGRWPWQVSLRYDGA----HLCGGSLLSGDWVLTAAHCFPERNRVLSRWRV 217
Query: 84 VLGEYNLAVKEGPEQVIPINSEELFVH----PLWNRSCVACGNDIALIKLSRSAQLGDAV 139
G AV + + + + + H P + + NDIAL+ LS L + +
Sbjct: 218 FAG----AVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYI 273
Query: 140 QLASLPPAGDILPNKTPCYITGWGRLYTNGPLPDKLQQARLPVVDYKHCSRWNWWGSTVK 199
Q LP AG L + C +TGWG G LQ+AR+P++ C+ +++G+ +K
Sbjct: 274 QPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIK 333
Query: 200 KTMVCAGGYIRSG---CNGDSGGPLNCP---TEDGGWQVHGVTSFVSAFGCNFIWKPTVF 253
M CA GY G C GDSGGP C + W++ G+ S+ GC KP V+
Sbjct: 334 PKMFCA-GYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSW--GTGCALAQKPGVY 390
Query: 254 TRVSAFIDWIEETIASH 270
T+VS F +WI + I +H
Sbjct: 391 TKVSDFREWIFQAIKTH 407
>gi|117956391 protease, serine, 33 [Homo sapiens]
Length = 280
Score = 141 bits (355), Expect = 7e-34
Identities = 97/280 (34%), Positives = 136/280 (48%), Gaps = 32/280 (11%)
Query: 9 LLLVAVASGYGPPSS-----HSSSRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLI 63
LL++ A G S+ SSR+V G D WPWQ S+Q+ + H CGGSLI
Sbjct: 12 LLVLGAAGTQGRKSAACGQPRMSSRIVGGRDGRDGEWPWQASIQHRGA----HVCGGSLI 67
Query: 64 APDWVVTAGHCISR---DLTYQVVLGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCVAC 120
AP WV+TA HC R Y+V LG L +P+ + + P ++
Sbjct: 68 APQWVLTAAHCFPRRALPAEYRVRLGALRLGSTSPRTLSVPVR--RVLLPPDYSED--GA 123
Query: 121 GNDIALIKLSRSAQLGDAVQLASLPPAGDILPNKTPCYITGWGRLYTNGPLPD--KLQQA 178
D+AL++L R L VQ LP G P TPC +TGWG L PLP+ LQ
Sbjct: 124 RGDLALLQLRRPVPLSARVQPVCLPVPGARPPPGTPCRVTGWGSLRPGVPLPEWRPLQGV 183
Query: 179 RLPVVDYKHCSRWNWWGSTVKKT-------MVCAG---GYIRSGCNGDSGGPLNCPTEDG 228
R+P++D + C G+ V + +CAG G+ + C GDSGGPL C + G
Sbjct: 184 RVPLLDSRTCDGLYHVGADVPQAERIVLPGSLCAGYPQGH-KDACQGDSGGPLTC-LQSG 241
Query: 229 GWQVHGVTSFVSAFGCNFIWKPTVFTRVSAFIDWIEETIA 268
W + GV S+ GC +P V+T V+ + WI+ ++
Sbjct: 242 SWVLVGVVSW--GKGCALPNRPGVYTSVATYSPWIQARVS 279
>gi|116292750 lipoprotein Lp(a) precursor [Homo sapiens]
Length = 2040
Score = 138 bits (348), Expect = 4e-33
Identities = 96/242 (39%), Positives = 133/242 (54%), Gaps = 33/242 (13%)
Query: 29 VVHGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLIAPDWVVTAGHCI---SRDLTYQVVL 85
+V G A P+SWPWQVSL+ + G H CGG+LI+P+WV+TA HC+ SR +Y+V+L
Sbjct: 1820 IVGGCVAHPHSWPWQVSLR-TRFGK--HFCGGTLISPEWVLTAAHCLKKSSRPSSYKVIL 1876
Query: 86 GEYNLAVKEGPEQVIPINSEELFVHPLWNRSCVACGNDIALIKLSRSAQLGDAVQLASLP 145
G + E Q I ++ LF+ P DIAL+KLSR A + D V A LP
Sbjct: 1877 GAHQEVNLESHVQEIEVS--RLFLEPTQA--------DIALLKLSRPAVITDKVMPACLP 1926
Query: 146 PAGDILPNKTPCYITGWGRLYTNGPL-PDKLQQARLPVVDYKHCSRWNWWGSTVKKTMVC 204
++ +T CYITGWG T G L++A+L V++ + C+ + + +C
Sbjct: 1927 SPDYMVTARTECYITGWGE--TQGTFGTGLLKEAQLLVIENEVCNHYKY---------IC 1975
Query: 205 AGGYIR--SGCNGDSGGPLNCPTEDGGWQVHGVTSFVSAFGCNFIWKPTVFTRVSAFIDW 262
A R C GDSGGPL C +D + + GVTS+ GC KP V+ RVS F+ W
Sbjct: 1976 AEHLARGTDSCQGDSGGPLVCFEKD-KYILQGVTSW--GLGCARPNKPGVYARVSRFVTW 2032
Query: 263 IE 264
IE
Sbjct: 2033 IE 2034
>gi|194018492 transmembrane protease, serine 11F [Homo sapiens]
Length = 438
Score = 138 bits (348), Expect = 4e-33
Identities = 91/267 (34%), Positives = 139/267 (52%), Gaps = 17/267 (6%)
Query: 2 MLRLLSSLLLVAVASGYGP-PSSHSSSRVVHG-EDAVPYSWPWQVSLQYEKSGSFYHTCG 59
M LL+S + + S P P+S S+ R+V G E A+ WPWQ SLQ SG H CG
Sbjct: 178 MRNLLNSRCGIRMTSSNMPLPASSSTQRIVQGRETAMEGEWPWQASLQLIGSG---HQCG 234
Query: 60 GSLIAPDWVVTAGHCISRDLTYQVVLGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCVA 119
SLI+ W++TA HC ++ + + + + N ++ +H ++R
Sbjct: 235 ASLISNTWLLTAAHCFWKNKDPTQWIATFGATITP---PAVKRNVRKIILHENYHRETNE 291
Query: 120 CGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNKTPCYITGWGRLYTNGPLPDKLQQAR 179
NDIAL++LS + + VQ LP + LP KT ++TG+G + +GP+ + L+QAR
Sbjct: 292 --NDIALVQLSTGVEFSNIVQRVCLPDSSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQAR 349
Query: 180 LPVVDYKHCSRWNWWGSTVKKTMVCAG---GYIRSGCNGDSGGPLNCPTEDGGWQVHGVT 236
+ + C+R + + + M+CAG G I C GDSGGPL D W + G+
Sbjct: 350 VETISTDVCNRKDVYDGLITPGMLCAGFMEGKI-DACKGDSGGPLVYDNHD-IWYIVGIV 407
Query: 237 SFVSAFGCNFIWKPTVFTRVSAFIDWI 263
S+ + C KP V+TRV+ + DWI
Sbjct: 408 SWGQS--CALPKKPGVYTRVTKYRDWI 432
>gi|4506145 protease, serine, 1 preproprotein [Homo sapiens]
Length = 247
Score = 138 bits (347), Expect = 6e-33
Identities = 101/266 (37%), Positives = 137/266 (51%), Gaps = 28/266 (10%)
Query: 9 LLLVAVASGYGPPSSHSSSRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLIAPDWV 68
L+L VA+ P ++V G + S P+QVSL S YH CGGSLI WV
Sbjct: 5 LILTFVAAALAAPFD-DDDKIVGGYNCEENSVPYQVSLN-----SGYHFCGGSLINEQWV 58
Query: 69 VTAGHCISRDLTYQVVLGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCVACGNDIALIK 128
V+AGHC + QV LGE+N+ V EG EQ IN+ ++ HP ++R + NDI LIK
Sbjct: 59 VSAGHCYKSRI--QVRLGEHNIEVLEGNEQF--INAAKIIRHPQYDRKTL--NNDIMLIK 112
Query: 129 LSRSAQLGDAVQLASLPPAGDILPNKTPCYITGWGRLYTNG-PLPDKLQQARLPVVDYKH 187
LS A + V SLP A T C I+GWG ++G PD+LQ PV+
Sbjct: 113 LSSRAVINARVSTISLPTAPP--ATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAK 170
Query: 188 CSRWNWWGSTVKKTMVCAGGYIRSG---CNGDSGGPLNCPTEDGGWQVHGVTSFVSAFGC 244
C + + M C G++ G C GDSGGP+ C Q+ GV S+ GC
Sbjct: 171 CEA--SYPGKITSNMFCV-GFLEGGKDSCQGDSGGPVVC-----NGQLQGVVSW--GDGC 220
Query: 245 NFIWKPTVFTRVSAFIDWIEETIASH 270
KP V+T+V ++ WI+ TIA++
Sbjct: 221 AQKNKPGVYTKVYNYVKWIKNTIAAN 246
>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
sapiens]
Length = 529
Score = 136 bits (343), Expect = 2e-32
Identities = 85/252 (33%), Positives = 130/252 (51%), Gaps = 26/252 (10%)
Query: 22 SSHSSSRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLIAPDWVVTAGHCISRDLT- 80
+S SR+V GE A+P +WPWQVSL + H CGGS+I P+W+VTA HC+ + L
Sbjct: 286 NSSRQSRIVGGESALPGAWPWQVSLHVQN----VHVCGGSIITPEWIVTAAHCVEKPLNN 341
Query: 81 ------YQVVLGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCVACGNDIALIKLSRSAQ 134
+ +L + + G + E++ HP N NDIAL+KL +
Sbjct: 342 PWHWTAFAGILRQSFMFYGAGYQV------EKVISHP--NYDSKTKNNDIALMKLQKPLT 393
Query: 135 LGDAVQLASLPPAGDILPNKTPCYITGWGRLYTNGPLPDKLQQARLPVVDYKHCSRWNWW 194
D V+ LP G +L + C+I+GWG G + L A++ +++ + C+ +
Sbjct: 394 FNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVY 453
Query: 195 GSTVKKTMVCAG---GYIRSGCNGDSGGPLNCPTEDGGWQVHGVTSFVSAFGCNFIWKPT 251
+ + M+CAG G + S C GDSGGPL +++ W + G TS+ S GC ++P
Sbjct: 454 DNLITPAMICAGFLQGNVDS-CQGDSGGPL-VTSKNNIWWLIGDTSWGS--GCAKAYRPG 509
Query: 252 VFTRVSAFIDWI 263
V+ V F DWI
Sbjct: 510 VYGNVMVFTDWI 521
>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
sapiens]
Length = 492
Score = 136 bits (343), Expect = 2e-32
Identities = 85/252 (33%), Positives = 130/252 (51%), Gaps = 26/252 (10%)
Query: 22 SSHSSSRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLIAPDWVVTAGHCISRDLT- 80
+S SR+V GE A+P +WPWQVSL + H CGGS+I P+W+VTA HC+ + L
Sbjct: 249 NSSRQSRIVGGESALPGAWPWQVSLHVQN----VHVCGGSIITPEWIVTAAHCVEKPLNN 304
Query: 81 ------YQVVLGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCVACGNDIALIKLSRSAQ 134
+ +L + + G + E++ HP N NDIAL+KL +
Sbjct: 305 PWHWTAFAGILRQSFMFYGAGYQV------EKVISHP--NYDSKTKNNDIALMKLQKPLT 356
Query: 135 LGDAVQLASLPPAGDILPNKTPCYITGWGRLYTNGPLPDKLQQARLPVVDYKHCSRWNWW 194
D V+ LP G +L + C+I+GWG G + L A++ +++ + C+ +
Sbjct: 357 FNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVY 416
Query: 195 GSTVKKTMVCAG---GYIRSGCNGDSGGPLNCPTEDGGWQVHGVTSFVSAFGCNFIWKPT 251
+ + M+CAG G + S C GDSGGPL +++ W + G TS+ S GC ++P
Sbjct: 417 DNLITPAMICAGFLQGNVDS-CQGDSGGPL-VTSKNNIWWLIGDTSWGS--GCAKAYRPG 472
Query: 252 VFTRVSAFIDWI 263
V+ V F DWI
Sbjct: 473 VYGNVMVFTDWI 484
>gi|58218970 protease, serine, 36 [Homo sapiens]
Length = 855
Score = 135 bits (341), Expect = 3e-32
Identities = 98/258 (37%), Positives = 133/258 (51%), Gaps = 27/258 (10%)
Query: 26 SSRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLIAPDWVVTAGHCISRDLT----- 80
S+R+V G +A P +WPWQVSL + H CGGSLIAP WV++A HC + T
Sbjct: 44 SARIVGGSNAQPGTWPWQVSLHHGGG----HICGGSLIAPSWVLSAAHCFMTNGTLEPAA 99
Query: 81 -YQVVLGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCVACGNDIALIKLSRSAQLGDAV 139
+ V+LG ++ ++GP + V P N S V G D+AL++L+ A LG AV
Sbjct: 100 EWSVLLGVHS---QDGPLDGAHTRAVAAIVVPA-NYSQVELGADLALLRLASPASLGPAV 155
Query: 140 QLASLPPAGDILPNKTPCYITGWGRLYTNGPLPDK--LQQARLPVVDYKHC----SRWNW 193
LP A + T C+ TGWG + PLP LQ+ L ++ C S+
Sbjct: 156 WPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGP 215
Query: 194 WGSTVK--KTMVCAG--GYIRSGCNGDSGGPLNCPTEDGGWQVHGVTSFVSAFGCNFIWK 249
+ T++ M+CAG R C GDSGGPL C E G W G+TSF FGC +
Sbjct: 216 FNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVC-EEGGRWFQAGITSF--GFGCGRRNR 272
Query: 250 PTVFTRVSAFIDWIEETI 267
P VFT V+ + WI E +
Sbjct: 273 PGVFTAVATYEAWIREQV 290
Score = 43.1 bits (100), Expect = 3e-04
Identities = 49/215 (22%), Positives = 77/215 (35%), Gaps = 19/215 (8%)
Query: 40 WPWQVSLQYEKSGSFYHTCGGSLIAPDWVVTAGHCISRDLTYQVVLGEYNLAVKEGPEQV 99
WPW + C G L+AP WV+ A HC+ R + V E L + G +
Sbjct: 601 WPWLAEVHVAGD----RVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLG-RAGASSL 655
Query: 100 IPINSEELFVHPLWNRSCVACGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNKTPCYI 159
+ V + + +AL++LS + + L PAG +P C++
Sbjct: 656 PQGHQVSRLVISIRLPQHLGLRPPLALLELSSRVEPSPSALPICLHPAG--IPPGASCWV 713
Query: 160 TGWGRLYTNGPLPDKLQQARLPVVDYKHCSRWNWWGSTVKKTM-VCAGGYIRSGCNGDSG 218
GW P+ A + ++ + C + G T+ V + C S
Sbjct: 714 LGWKEPQDRVPV-----AAAVSILTQRICD-CLYQGILPPGTLCVLYAEGQENRCEMTSA 767
Query: 219 GPLNCPTEDGGW-----QVHGVTSFVSAFGCNFIW 248
PL C +G W V G +A G W
Sbjct: 768 PPLLCQMTEGSWILVGMAVQGSRELFAAIGPEEAW 802
Score = 40.0 bits (92), Expect = 0.002
Identities = 64/252 (25%), Positives = 95/252 (37%), Gaps = 47/252 (18%)
Query: 32 GEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLIAPDWVVTAGHCI---------SRDLTYQ 82
G+ P +WPW+ + S C G+L++ WV+ C RDL
Sbjct: 326 GKAPRPGAWPWEAQVMVPGS----RPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAW 381
Query: 83 VVLGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCVACGNDIALIKLSRSAQLGDAVQLA 142
VL L + E+V + E + W+ + +D+AL++L L A +
Sbjct: 382 RVL----LPSRPRAERVARLVQHE---NASWDNA-----SDLALLQLRTPVNLSAASRPV 429
Query: 143 SLP-PAGDILPNKTPCYITGWGRLYTNGPL--PDKLQQARLPVVDYKHCSRWNWWGSTV- 198
LP P LP C + WGR P P L +A L + HC + G+ V
Sbjct: 430 CLPHPEHYFLPGSR-CRLARWGR---GEPALGPGALLEAELLGGWWCHC-LYGRQGAAVP 484
Query: 199 ----KKTMVCAGGYIR---SGCNGDSGGPLNCPTEDGGWQVHGVTSFVSAFGCNFIWKPT 251
+C + C DS L C E+G W + G+ F S GC +P
Sbjct: 485 LPGDPPHALCPAYQEKEEVGSCWNDSRWSLLC-QEEGTWFLAGIRDFPS--GC---LRPR 538
Query: 252 VFTRVSAFIDWI 263
F + WI
Sbjct: 539 AFFPLQTHGPWI 550
>gi|148231605 ovochymase 2 [Homo sapiens]
Length = 564
Score = 135 bits (341), Expect = 3e-32
Identities = 89/258 (34%), Positives = 128/258 (49%), Gaps = 26/258 (10%)
Query: 27 SRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLIAPDWVVTAGHCIS-RDL--TYQV 83
SR++ G S+PWQVSL+ + H CGGS+++P WV+TA HCI+ R++ T V
Sbjct: 50 SRILGGSQVEKGSYPWQVSLKQRQK----HICGGSIVSPQWVITAAHCIANRNIVSTLNV 105
Query: 84 VLGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCVACGNDIALIKLSRSAQLGDAVQLAS 143
GEY+L+ + EQ + I E + +HP ++ DIAL+K++ + Q G V
Sbjct: 106 TAGEYDLSQTDPGEQTLTI--ETVIIHPHFSTK-KPMDYDIALLKMAGAFQFGHFVGPIC 162
Query: 144 LPPAGDILPNKTPCYITGWGRLYTNGPLPDKLQQARLPVVDYKHC--SRWNWWGSTVKKT 201
LP + C GWGRL G L LQ+ LP++ ++ C + KT
Sbjct: 163 LPELREQFEAGFICTTAGWGRLTEGGVLSQVLQEVNLPILTWEECVAALLTLKRPISGKT 222
Query: 202 MVCAG--GYIRSGCNGDSGGPLNCPTEDGGWQVHGVTSFVSAFGCNFIWK---------- 249
+C G R C GDSGG L C + G W + GVTS+ GC W+
Sbjct: 223 FLCTGFPDGGRDACQGDSGGSLMCRNKKGAWTLAGVTSW--GLGCGRGWRNNVRKSDQGS 280
Query: 250 PTVFTRVSAFIDWIEETI 267
P +FT +S + WI E I
Sbjct: 281 PGIFTDISKVLPWIHEHI 298
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 134 bits (337), Expect = 8e-32
Identities = 88/254 (34%), Positives = 132/254 (51%), Gaps = 20/254 (7%)
Query: 21 PSSHSSSRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLIAPDWVVTAGHCI---SR 77
P++ + R++ G + P WPWQ SLQ E SG H CG LIA WV+T HC
Sbjct: 794 PAARMNKRILGGRTSRPGRWPWQCSLQSEPSG---HICGCVLIAKKWVLTVAHCFEGREN 850
Query: 78 DLTYQVVLGEYNLAVKEGPEQVIPIN-SEELFVHPLWNRSCVACGNDIALIKLSRSAQLG 136
++VVLG NL + P + + + +HP ++R+ V DI++++LS
Sbjct: 851 AAVWKVVLGINNL---DHPSVFMQTRFVKTIILHPRYSRAVV--DYDISIVELSEDISET 905
Query: 137 DAVQLASLPPAGDILPNKTPCYITGWGRLYTNGPLPDKLQQARLPVVDYKHCSRWNWWGS 196
V+ LP L T CYITGWG + +P KLQ+ + ++ +HC + +
Sbjct: 906 GYVRPVCLPNPEQWLEPDTYCYITGWGHM--GNKMPFKLQEGEVRIISLEHCQSY-FDMK 962
Query: 197 TVKKTMVCAG---GYIRSGCNGDSGGPLNCPTEDGGWQVHGVTSFVSAFGCNFIWKPTVF 253
T+ M+CAG G + S C GDSGGPL C G W + G+TS+ S + + P V+
Sbjct: 963 TITTRMICAGYESGTVDS-CMGDSGGPLVCEKPGGRWTLFGLTSWGSVC-FSKVLGPGVY 1020
Query: 254 TRVSAFIDWIEETI 267
+ VS F++WI+ I
Sbjct: 1021 SNVSYFVEWIKRQI 1034
>gi|4506147 protease, serine, 2 preproprotein [Homo sapiens]
Length = 247
Score = 134 bits (336), Expect = 1e-31
Identities = 98/266 (36%), Positives = 139/266 (52%), Gaps = 28/266 (10%)
Query: 9 LLLVAVASGYGPPSSHSSSRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLIAPDWV 68
L+L VA+ P ++V G S P+QVSL S YH CGGSLI+ WV
Sbjct: 5 LILTFVAAAVAAPFD-DDDKIVGGYICEENSVPYQVSLN-----SGYHFCGGSLISEQWV 58
Query: 69 VTAGHCISRDLTYQVVLGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCVACGNDIALIK 128
V+AGHC + QV LGE+N+ V EG EQ IN+ ++ HP +N + NDI LIK
Sbjct: 59 VSAGHCYKSRI--QVRLGEHNIEVLEGNEQF--INAAKIIRHPKYNSRTL--DNDILLIK 112
Query: 129 LSRSAQLGDAVQLASLPPAGDILPNKTPCYITGWGRLYTNG-PLPDKLQQARLPVVDYKH 187
LS A + V SLP A T I+GWG ++G PD+LQ PV+
Sbjct: 113 LSSPAVINSRVSAISLPTAPPAA--GTESLISGWGNTLSSGADYPDELQCLDAPVLSQAE 170
Query: 188 CSRWNWWGSTVKKTMVCAGGYIRSG---CNGDSGGPLNCPTEDGGWQVHGVTSFVSAFGC 244
C + + M C G++ G C GDSGGP+ +G ++ G+ S+ +GC
Sbjct: 171 CEA--SYPGKITNNMFCV-GFLEGGKDSCQGDSGGPV---VSNG--ELQGIVSW--GYGC 220
Query: 245 NFIWKPTVFTRVSAFIDWIEETIASH 270
+P V+T+V ++DWI++TIA++
Sbjct: 221 AQKNRPGVYTKVYNYVDWIKDTIAAN 246
>gi|4506153 prostasin preproprotein [Homo sapiens]
Length = 343
Score = 133 bits (335), Expect = 1e-31
Identities = 87/255 (34%), Positives = 130/255 (50%), Gaps = 26/255 (10%)
Query: 27 SRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLIAPDWVVTAGHCISRDL---TYQV 83
+R+ G AV WPWQVS+ YE H CGGSL++ WV++A HC + Y+V
Sbjct: 43 ARITGGSSAVAGQWPWQVSITYEG----VHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEV 98
Query: 84 VLGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCVACGNDIALIKLSRSAQLGDAVQLAS 143
LG + L +V + +++ HP + + DIAL++LSR ++
Sbjct: 99 KLGAHQLDSYSEDAKVSTL--KDIIPHPSYLQE--GSQGDIALLQLSRPITFSRYIRPIC 154
Query: 144 LPPAGDILPNKTPCYITGWGRLYTNGPL--PDKLQQARLPVVDYKHCS-RWNWWGST--- 197
LP A PN C +TGWG + + L P LQQ +P++ + C+ +N
Sbjct: 155 LPAANASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCLYNIDAKPEEP 214
Query: 198 --VKKTMVCAGGYIRSG---CNGDSGGPLNCPTEDGGWQVHGVTSFVSAFGCNFIWKPTV 252
V++ MVCA GY+ G C GDSGGPL+CP E G W + G+ S+ A G +P V
Sbjct: 215 HFVQEDMVCA-GYVEGGKDACQGDSGGPLSCPVE-GLWYLTGIVSWGDACGARN--RPGV 270
Query: 253 FTRVSAFIDWIEETI 267
+T S++ WI+ +
Sbjct: 271 YTLASSYASWIQSKV 285
>gi|156938340 transmembrane tryptase preproprotein [Homo sapiens]
Length = 321
Score = 133 bits (335), Expect = 1e-31
Identities = 94/277 (33%), Positives = 135/277 (48%), Gaps = 22/277 (7%)
Query: 1 MMLRLLSSLLLVAVASGYGPPS-SHSSSRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCG 59
++L + + L + G G P S + R+V G A +WPWQ SL+ + H CG
Sbjct: 9 LLLLAVPGVSLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRR----VHVCG 64
Query: 60 GSLIAPDWVVTAGHCISRDLT---YQVVLGEYNLAVKEGPEQVIPINSEELFVHPLWNRS 116
GSL++P WV+TA HC S L YQV LGE + + V ++ +H +
Sbjct: 65 GSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITLSPHFSTV-----RQIILHSSPSGQ 119
Query: 117 CVACGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNKTPCYITGWGRLYTNGPLPD--K 174
G DIAL++LS L + LP A D C++TGWG PLP
Sbjct: 120 PGTSG-DIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYS 178
Query: 175 LQQARLPVVDYKHCSR--WNWWGSTVKKTMVCAGGYIRSGCNGDSGGPLNCPTEDGGWQV 232
L++ ++ VVD + C R GS ++ M+CA G C DSGGPL C +G W
Sbjct: 179 LREVKVSVVDTETCRRDYPGPGGSILQPDMLCARG-PGDACQDDSGGPLVCQV-NGAWVQ 236
Query: 233 HGVTSFVSAFGCNFIWKPTVFTRVSAFIDWIEETIAS 269
G+ S+ GC +P V+TRV A+++WI I +
Sbjct: 237 AGIVSW--GEGCGRPNRPGVYTRVPAYVNWIRRHITA 271
>gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens]
Length = 247
Score = 133 bits (334), Expect = 2e-31
Identities = 99/266 (37%), Positives = 138/266 (51%), Gaps = 28/266 (10%)
Query: 9 LLLVAVASGYGPPSSHSSSRVVHGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLIAPDWV 68
L+L V + P ++V G S P+QVSL SGS H CGGSLI+ WV
Sbjct: 5 LILAFVGAAVAVPFD-DDDKIVGGYTCEENSLPYQVSLN---SGS--HFCGGSLISEQWV 58
Query: 69 VTAGHCISRDLTYQVVLGEYNLAVKEGPEQVIPINSEELFVHPLWNRSCVACGNDIALIK 128
V+A HC + QV LGE+N+ V EG EQ IN+ ++ HP +NR + NDI LIK
Sbjct: 59 VSAAHCYKTRI--QVRLGEHNIKVLEGNEQF--INAAKIIRHPKYNRDTL--DNDIMLIK 112
Query: 129 LSRSAQLGDAVQLASLPPAGDILPNKTPCYITGWGRLYTNG-PLPDKLQQARLPVVDYKH 187
LS A + V SLP A T C I+GWG + G PD+L+ PV+
Sbjct: 113 LSSPAVINARVSTISLPTAPPAA--GTECLISGWGNTLSFGADYPDELKCLDAPVLTQAE 170
Query: 188 CSRWNWWGSTVKKTMVCAGGYIRSG---CNGDSGGPLNCPTEDGGWQVHGVTSFVSAFGC 244
C + + +M C G++ G C DSGGP+ C Q+ GV S+ GC
Sbjct: 171 CKA--SYPGKITNSMFCV-GFLEGGKDSCQRDSGGPVVC-----NGQLQGVVSW--GHGC 220
Query: 245 NFIWKPTVFTRVSAFIDWIEETIASH 270
+ +P V+T+V ++DWI++TIA++
Sbjct: 221 AWKNRPGVYTKVYNYVDWIKDTIAAN 246
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.457
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,586,528
Number of Sequences: 37866
Number of extensions: 531098
Number of successful extensions: 1811
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 156
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 1104
Number of HSP's gapped (non-prelim): 194
length of query: 270
length of database: 18,247,518
effective HSP length: 101
effective length of query: 169
effective length of database: 14,423,052
effective search space: 2437495788
effective search space used: 2437495788
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.