Guide to the Human Genome
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Search of human proteins with 116006967

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens]
         (422 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens]                 856   0.0  
gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens]           355   3e-98
gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens]            337   1e-92
gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens]           333   1e-91
gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens]           323   2e-88
gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens]               316   3e-86
gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens]           316   3e-86
gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens]            316   3e-86
gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens]            316   3e-86
gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens]           315   5e-86
gi|236464356 neuregulin 1 isoform HRG-gamma3 [Homo sapiens]           291   8e-79
gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens]              286   3e-77
gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens]                  286   3e-77
gi|236462984 neuregulin 1 isoform HRG-gamma2 [Homo sapiens]           280   1e-75
gi|116006965 neuregulin 1 isoform HRG-gamma [Homo sapiens]            273   3e-73
gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]                      196   3e-50
gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]                      196   3e-50
gi|7669530 neuregulin 2 isoform 3 [Homo sapiens]                      188   9e-48
gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]                      188   9e-48
gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens]                   160   2e-39
gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens]               112   6e-25
gi|115298665 neurotrimin isoform 2 [Homo sapiens]                      56   7e-08
gi|7705413 neurotrimin isoform 1 [Homo sapiens]                        56   7e-08
gi|110349719 titin isoform N2-A [Homo sapiens]                         54   2e-07
gi|221316757 neurotrimin isoform 3 [Homo sapiens]                      53   6e-07
gi|66730481 neuregulin 3 [Homo sapiens]                                51   2e-06
gi|45594240 limbic system-associated membrane protein [Homo sapi...    51   2e-06
gi|221316762 neurotrimin isoform 4 [Homo sapiens]                      50   3e-06
gi|110349717 titin isoform novex-2 [Homo sapiens]                      50   5e-06
gi|110349713 titin isoform novex-1 [Homo sapiens]                      50   5e-06

>gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens]
          Length = 422

 Score =  856 bits (2212), Expect = 0.0
 Identities = 422/422 (100%), Positives = 422/422 (100%)

Query: 1   MRWRRAPRRSGRPGPRAQRPGSAARSSPPLPLLPLLLLLGTAALAPGAAAGNEAAPAGAS 60
           MRWRRAPRRSGRPGPRAQRPGSAARSSPPLPLLPLLLLLGTAALAPGAAAGNEAAPAGAS
Sbjct: 1   MRWRRAPRRSGRPGPRAQRPGSAARSSPPLPLLPLLLLLGTAALAPGAAAGNEAAPAGAS 60

Query: 61  VCYSSPPSVGSVQELAQRAAVVIEGKVHPQRRQQGALDRKAAAAAGEAGAWGGDREPPAA 120
           VCYSSPPSVGSVQELAQRAAVVIEGKVHPQRRQQGALDRKAAAAAGEAGAWGGDREPPAA
Sbjct: 61  VCYSSPPSVGSVQELAQRAAVVIEGKVHPQRRQQGALDRKAAAAAGEAGAWGGDREPPAA 120

Query: 121 GPRALGPPAEEPLLAANGTVPSWPTAPVPSAGEPGEEAPYLVKVHQVWAVKAGGLKKDSL 180
           GPRALGPPAEEPLLAANGTVPSWPTAPVPSAGEPGEEAPYLVKVHQVWAVKAGGLKKDSL
Sbjct: 121 GPRALGPPAEEPLLAANGTVPSWPTAPVPSAGEPGEEAPYLVKVHQVWAVKAGGLKKDSL 180

Query: 181 LTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFRASFPPLETGRNLKKEV 240
           LTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFRASFPPLETGRNLKKEV
Sbjct: 181 LTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFRASFPPLETGRNLKKEV 240

Query: 241 SRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQN 300
           SRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQN
Sbjct: 241 SRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQN 300

Query: 301 IKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHL 360
           IKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHL
Sbjct: 301 IKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHL 360

Query: 361 VKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPFLSL 420
           VKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPFLSL
Sbjct: 361 VKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPFLSL 420

Query: 421 PE 422
           PE
Sbjct: 421 PE 422


>gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens]
          Length = 207

 Score =  355 bits (912), Expect = 3e-98
 Identities = 177/186 (95%), Positives = 178/186 (95%)

Query: 237 KKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 296
           KK  S    +  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN
Sbjct: 22  KKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81

Query: 297 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTG 356
           KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTG
Sbjct: 82  KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTG 141

Query: 357 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTP 416
           TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTP
Sbjct: 142 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTP 201

Query: 417 FLSLPE 422
           FLSLPE
Sbjct: 202 FLSLPE 207


>gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens]
          Length = 241

 Score =  337 bits (864), Expect = 1e-92
 Identities = 176/220 (80%), Positives = 178/220 (80%), Gaps = 34/220 (15%)

Query: 237 KKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 296
           KK  S    +  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN
Sbjct: 22  KKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81

Query: 297 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------- 348
           KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN        
Sbjct: 82  KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 141

Query: 349 --------------------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 382
                                     +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD
Sbjct: 142 STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 201

Query: 383 LSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPFLSLPE 422
           LSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPFLSLPE
Sbjct: 202 LSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPFLSLPE 241


>gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens]
          Length = 590

 Score =  333 bits (855), Expect = 1e-91
 Identities = 163/163 (100%), Positives = 163/163 (100%)

Query: 249 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 308
           ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 13  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72

Query: 309 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEK 368
           KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEK
Sbjct: 73  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEK 132

Query: 369 TFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY 411
           TFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY
Sbjct: 133 TFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY 175


>gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens]
          Length = 607

 Score =  323 bits (827), Expect = 2e-88
 Identities = 163/180 (90%), Positives = 163/180 (90%), Gaps = 17/180 (9%)

Query: 249 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 308
           ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 13  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72

Query: 309 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-----------------ATS 351
           KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN                 ATS
Sbjct: 73  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSATS 132

Query: 352 TSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY 411
           TSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY
Sbjct: 133 TSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY 192


>gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens]
          Length = 459

 Score =  316 bits (809), Expect = 3e-86
 Identities = 165/209 (78%), Positives = 167/209 (79%), Gaps = 34/209 (16%)

Query: 237 KKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 296
           KK  S    +  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN
Sbjct: 22  KKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81

Query: 297 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------- 348
           KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN        
Sbjct: 82  KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 141

Query: 349 --------------------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 382
                                     +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD
Sbjct: 142 STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 201

Query: 383 LSNPSRYLCKCPNEFTGDRCQNYVMASFY 411
           LSNPSRYLCKCPNEFTGDRCQNYVMASFY
Sbjct: 202 LSNPSRYLCKCPNEFTGDRCQNYVMASFY 230


>gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens]
          Length = 420

 Score =  316 bits (809), Expect = 3e-86
 Identities = 165/209 (78%), Positives = 167/209 (79%), Gaps = 34/209 (16%)

Query: 237 KKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 296
           KK  S    +  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN
Sbjct: 22  KKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81

Query: 297 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------- 348
           KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN        
Sbjct: 82  KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 141

Query: 349 --------------------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 382
                                     +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD
Sbjct: 142 STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 201

Query: 383 LSNPSRYLCKCPNEFTGDRCQNYVMASFY 411
           LSNPSRYLCKCPNEFTGDRCQNYVMASFY
Sbjct: 202 LSNPSRYLCKCPNEFTGDRCQNYVMASFY 230


>gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens]
          Length = 637

 Score =  316 bits (809), Expect = 3e-86
 Identities = 165/209 (78%), Positives = 167/209 (79%), Gaps = 34/209 (16%)

Query: 237 KKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 296
           KK  S    +  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN
Sbjct: 22  KKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81

Query: 297 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------- 348
           KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN        
Sbjct: 82  KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 141

Query: 349 --------------------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 382
                                     +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD
Sbjct: 142 STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 201

Query: 383 LSNPSRYLCKCPNEFTGDRCQNYVMASFY 411
           LSNPSRYLCKCPNEFTGDRCQNYVMASFY
Sbjct: 202 LSNPSRYLCKCPNEFTGDRCQNYVMASFY 230


>gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens]
          Length = 645

 Score =  316 bits (809), Expect = 3e-86
 Identities = 165/209 (78%), Positives = 167/209 (79%), Gaps = 34/209 (16%)

Query: 237 KKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 296
           KK  S    +  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN
Sbjct: 22  KKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81

Query: 297 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------- 348
           KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN        
Sbjct: 82  KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 141

Query: 349 --------------------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 382
                                     +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD
Sbjct: 142 STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 201

Query: 383 LSNPSRYLCKCPNEFTGDRCQNYVMASFY 411
           LSNPSRYLCKCPNEFTGDRCQNYVMASFY
Sbjct: 202 LSNPSRYLCKCPNEFTGDRCQNYVMASFY 230


>gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens]
          Length = 624

 Score =  315 bits (807), Expect = 5e-86
 Identities = 162/197 (82%), Positives = 163/197 (82%), Gaps = 34/197 (17%)

Query: 249 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 308
           ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 13  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72

Query: 309 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------------------- 348
           KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN                    
Sbjct: 73  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 132

Query: 349 --------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 394
                         +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP
Sbjct: 133 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 192

Query: 395 NEFTGDRCQNYVMASFY 411
           NEFTGDRCQNYVMASFY
Sbjct: 193 NEFTGDRCQNYVMASFY 209


>gi|236464356 neuregulin 1 isoform HRG-gamma3 [Homo sapiens]
          Length = 177

 Score =  291 bits (745), Expect = 8e-79
 Identities = 147/156 (94%), Positives = 148/156 (94%)

Query: 237 KKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 296
           KK  S    +  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN
Sbjct: 22  KKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81

Query: 297 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTG 356
           KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTG
Sbjct: 82  KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTG 141

Query: 357 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 392
           TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK
Sbjct: 142 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 177


>gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens]
          Length = 640

 Score =  286 bits (731), Expect = 3e-77
 Identities = 153/204 (75%), Positives = 155/204 (75%), Gaps = 34/204 (16%)

Query: 237 KKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 296
           KK  S    +  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN
Sbjct: 22  KKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81

Query: 297 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------- 348
           KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN        
Sbjct: 82  KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 141

Query: 349 --------------------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 382
                                     +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD
Sbjct: 142 STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 201

Query: 383 LSNPSRYLCKCPNEFTGDRCQNYV 406
           LSNPSRYLCKC   FTG RC   V
Sbjct: 202 LSNPSRYLCKCQPGFTGARCTENV 225


>gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens]
          Length = 462

 Score =  286 bits (731), Expect = 3e-77
 Identities = 153/204 (75%), Positives = 155/204 (75%), Gaps = 34/204 (16%)

Query: 237 KKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 296
           KK  S    +  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN
Sbjct: 22  KKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81

Query: 297 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------- 348
           KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN        
Sbjct: 82  KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 141

Query: 349 --------------------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 382
                                     +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD
Sbjct: 142 STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 201

Query: 383 LSNPSRYLCKCPNEFTGDRCQNYV 406
           LSNPSRYLCKC   FTG RC   V
Sbjct: 202 LSNPSRYLCKCQPGFTGARCTENV 225


>gi|236462984 neuregulin 1 isoform HRG-gamma2 [Homo sapiens]
          Length = 194

 Score =  280 bits (717), Expect = 1e-75
 Identities = 147/173 (84%), Positives = 148/173 (85%), Gaps = 17/173 (9%)

Query: 237 KKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 296
           KK  S    +  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN
Sbjct: 22  KKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81

Query: 297 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------- 348
           KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN        
Sbjct: 82  KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 141

Query: 349 ---------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 392
                    ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK
Sbjct: 142 STEGAYVSSATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 194


>gi|116006965 neuregulin 1 isoform HRG-gamma [Homo sapiens]
          Length = 211

 Score =  273 bits (697), Expect = 3e-73
 Identities = 146/190 (76%), Positives = 148/190 (77%), Gaps = 34/190 (17%)

Query: 237 KKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 296
           KK  S    +  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN
Sbjct: 22  KKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81

Query: 297 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------- 348
           KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN        
Sbjct: 82  KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 141

Query: 349 --------------------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 382
                                     +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD
Sbjct: 142 STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 201

Query: 383 LSNPSRYLCK 392
           LSNPSRYLCK
Sbjct: 202 LSNPSRYLCK 211


>gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]
          Length = 844

 Score =  196 bits (498), Expect = 3e-50
 Identities = 141/418 (33%), Positives = 208/418 (49%), Gaps = 92/418 (22%)

Query: 9   RSGRPGPRAQRPGSAARSSP---PLPLLPLLLLLGTAALAPGAAAGN---EAAPA----- 57
           RS        RP +     P   P P  P       AA +  AAAG    + AP      
Sbjct: 48  RSSSNNSSISRPAAPPEPRPQQQPQPRSPAARR--AAARSRAAAAGGMRRDPAPGFSMLL 105

Query: 58  -GASV-CYSSPPSVGSVQELAQRAAVVIEGKVHPQRRQQGALDRKAAAAAGEAGAWGGDR 115
            G S+ CYS  PS+ SVQ+ A +A VV+EGKV      QG +    +++          R
Sbjct: 106 FGVSLACYS--PSLKSVQDQAYKAPVVVEGKV------QGLVPAGGSSS-------NSTR 150

Query: 116 EPPAAGPRALGPPAEEPLLAANGTVPSWPTAPVPSAGEPGEEAPYLVKVHQVWAVKAGGL 175
           EPPA+G  AL                                    VKV   W +++GGL
Sbjct: 151 EPPASGRVAL------------------------------------VKVLDKWPLRSGGL 174

Query: 176 KKDSLLTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFRASFPPLET-GR 234
           +++ +++V           SC  L+ + RYIFF+EP     +  P  F+ +F PL+T G+
Sbjct: 175 QREQVISVG----------SCVPLERNQRYIFFLEP-----TEQPLVFKTAFAPLDTNGK 219

Query: 235 NLKKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNR 294
           NLKKEV ++LC  CA  P+LK+MKSQ    G K  L+CE ++      ++WFK+G ELNR
Sbjct: 220 NLKKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNR 279

Query: 295 KNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATST 352
               ++I+I+   G+  S L+ NK  + D+GEY+C+  + LG D+    + +   + T +
Sbjct: 280 S---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLS 336

Query: 353 STTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF 410
           S +G  H  KC E  K++CVNGG C+ ++ ++  S   CKCP  +TGDRCQ + M +F
Sbjct: 337 SWSG--HARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVNF 389


>gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]
          Length = 852

 Score =  196 bits (498), Expect = 3e-50
 Identities = 141/418 (33%), Positives = 208/418 (49%), Gaps = 92/418 (22%)

Query: 9   RSGRPGPRAQRPGSAARSSP---PLPLLPLLLLLGTAALAPGAAAGN---EAAPA----- 57
           RS        RP +     P   P P  P       AA +  AAAG    + AP      
Sbjct: 48  RSSSNNSSISRPAAPPEPRPQQQPQPRSPAARR--AAARSRAAAAGGMRRDPAPGFSMLL 105

Query: 58  -GASV-CYSSPPSVGSVQELAQRAAVVIEGKVHPQRRQQGALDRKAAAAAGEAGAWGGDR 115
            G S+ CYS  PS+ SVQ+ A +A VV+EGKV      QG +    +++          R
Sbjct: 106 FGVSLACYS--PSLKSVQDQAYKAPVVVEGKV------QGLVPAGGSSS-------NSTR 150

Query: 116 EPPAAGPRALGPPAEEPLLAANGTVPSWPTAPVPSAGEPGEEAPYLVKVHQVWAVKAGGL 175
           EPPA+G  AL                                    VKV   W +++GGL
Sbjct: 151 EPPASGRVAL------------------------------------VKVLDKWPLRSGGL 174

Query: 176 KKDSLLTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFRASFPPLET-GR 234
           +++ +++V           SC  L+ + RYIFF+EP     +  P  F+ +F PL+T G+
Sbjct: 175 QREQVISVG----------SCVPLERNQRYIFFLEP-----TEQPLVFKTAFAPLDTNGK 219

Query: 235 NLKKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNR 294
           NLKKEV ++LC  CA  P+LK+MKSQ    G K  L+CE ++      ++WFK+G ELNR
Sbjct: 220 NLKKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNR 279

Query: 295 KNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATST 352
               ++I+I+   G+  S L+ NK  + D+GEY+C+  + LG D+    + +   + T +
Sbjct: 280 S---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLS 336

Query: 353 STTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF 410
           S +G  H  KC E  K++CVNGG C+ ++ ++  S   CKCP  +TGDRCQ + M +F
Sbjct: 337 SWSG--HARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVNF 389


>gi|7669530 neuregulin 2 isoform 3 [Homo sapiens]
          Length = 858

 Score =  188 bits (477), Expect = 9e-48
 Identities = 138/410 (33%), Positives = 202/410 (49%), Gaps = 92/410 (22%)

Query: 9   RSGRPGPRAQRPGSAARSSP---PLPLLPLLLLLGTAALAPGAAAGN---EAAPA----- 57
           RS        RP +     P   P P  P       AA +  AAAG    + AP      
Sbjct: 48  RSSSNNSSISRPAAPPEPRPQQQPQPRSPAARR--AAARSRAAAAGGMRRDPAPGFSMLL 105

Query: 58  -GASV-CYSSPPSVGSVQELAQRAAVVIEGKVHPQRRQQGALDRKAAAAAGEAGAWGGDR 115
            G S+ CYS  PS+ SVQ+ A +A VV+EGKV      QG +    +++          R
Sbjct: 106 FGVSLACYS--PSLKSVQDQAYKAPVVVEGKV------QGLVPAGGSSS-------NSTR 150

Query: 116 EPPAAGPRALGPPAEEPLLAANGTVPSWPTAPVPSAGEPGEEAPYLVKVHQVWAVKAGGL 175
           EPPA+G  AL                                    VKV   W +++GGL
Sbjct: 151 EPPASGRVAL------------------------------------VKVLDKWPLRSGGL 174

Query: 176 KKDSLLTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFRASFPPLET-GR 234
           +++ +++V           SC  L+ + RYIFF+EP     +  P  F+ +F PL+T G+
Sbjct: 175 QREQVISVG----------SCVPLERNQRYIFFLEP-----TEQPLVFKTAFAPLDTNGK 219

Query: 235 NLKKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNR 294
           NLKKEV ++LC  CA  P+LK+MKSQ    G K  L+CE ++      ++WFK+G ELNR
Sbjct: 220 NLKKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNR 279

Query: 295 KNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATST 352
               ++I+I+   G+  S L+ NK  + D+GEY+C+  + LG D+    + +   + T +
Sbjct: 280 S---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLS 336

Query: 353 STTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRC 402
           S +G  H  KC E  K++CVNGG C+ ++ ++  S   CKCPN F G RC
Sbjct: 337 SWSG--HARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPNGFFGQRC 381


>gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]
          Length = 850

 Score =  188 bits (477), Expect = 9e-48
 Identities = 138/410 (33%), Positives = 202/410 (49%), Gaps = 92/410 (22%)

Query: 9   RSGRPGPRAQRPGSAARSSP---PLPLLPLLLLLGTAALAPGAAAGN---EAAPA----- 57
           RS        RP +     P   P P  P       AA +  AAAG    + AP      
Sbjct: 48  RSSSNNSSISRPAAPPEPRPQQQPQPRSPAARR--AAARSRAAAAGGMRRDPAPGFSMLL 105

Query: 58  -GASV-CYSSPPSVGSVQELAQRAAVVIEGKVHPQRRQQGALDRKAAAAAGEAGAWGGDR 115
            G S+ CYS  PS+ SVQ+ A +A VV+EGKV      QG +    +++          R
Sbjct: 106 FGVSLACYS--PSLKSVQDQAYKAPVVVEGKV------QGLVPAGGSSS-------NSTR 150

Query: 116 EPPAAGPRALGPPAEEPLLAANGTVPSWPTAPVPSAGEPGEEAPYLVKVHQVWAVKAGGL 175
           EPPA+G  AL                                    VKV   W +++GGL
Sbjct: 151 EPPASGRVAL------------------------------------VKVLDKWPLRSGGL 174

Query: 176 KKDSLLTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFRASFPPLET-GR 234
           +++ +++V           SC  L+ + RYIFF+EP     +  P  F+ +F PL+T G+
Sbjct: 175 QREQVISVG----------SCVPLERNQRYIFFLEP-----TEQPLVFKTAFAPLDTNGK 219

Query: 235 NLKKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNR 294
           NLKKEV ++LC  CA  P+LK+MKSQ    G K  L+CE ++      ++WFK+G ELNR
Sbjct: 220 NLKKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNR 279

Query: 295 KNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATST 352
               ++I+I+   G+  S L+ NK  + D+GEY+C+  + LG D+    + +   + T +
Sbjct: 280 S---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLS 336

Query: 353 STTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRC 402
           S +G  H  KC E  K++CVNGG C+ ++ ++  S   CKCPN F G RC
Sbjct: 337 SWSG--HARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPNGFFGQRC 381


>gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens]
          Length = 296

 Score =  160 bits (405), Expect = 2e-39
 Identities = 74/86 (86%), Positives = 77/86 (89%)

Query: 337 SASANITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNE 396
           +   N+      +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNE
Sbjct: 211 TTETNLQTAPKLSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNE 270

Query: 397 FTGDRCQNYVMASFYSTSTPFLSLPE 422
           FTGDRCQNYVMASFYSTSTPFLSLPE
Sbjct: 271 FTGDRCQNYVMASFYSTSTPFLSLPE 296


>gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens]
          Length = 308

 Score =  112 bits (280), Expect = 6e-25
 Identities = 53/66 (80%), Positives = 56/66 (84%)

Query: 341 NITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGD 400
           +I+I +  ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC   FTG 
Sbjct: 6   HISIEDITATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGA 65

Query: 401 RCQNYV 406
           RC   V
Sbjct: 66  RCTENV 71


>gi|115298665 neurotrimin isoform 2 [Homo sapiens]
          Length = 344

 Score = 55.8 bits (133), Expect = 7e-08
 Identities = 37/113 (32%), Positives = 53/113 (46%), Gaps = 5/113 (4%)

Query: 251 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310
           PP + E K      G K  L+CE S+   S  F+W+K+   L    K   +K++ +P  S
Sbjct: 222 PPYISEAKGTGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK--GVKVENRPFLS 278

Query: 311 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKC 363
           +L     S  D G Y C   +KLG+ +AS  I +    A S  + GTS    C
Sbjct: 279 KLIFFNVSEHDYGNYTCVASNKLGHTNAS--IMLFGPGAVSEVSNGTSRRAGC 329


>gi|7705413 neurotrimin isoform 1 [Homo sapiens]
          Length = 344

 Score = 55.8 bits (133), Expect = 7e-08
 Identities = 37/113 (32%), Positives = 53/113 (46%), Gaps = 5/113 (4%)

Query: 251 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310
           PP + E K      G K  L+CE S+   S  F+W+K+   L    K   +K++ +P  S
Sbjct: 222 PPYISEAKGTGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK--GVKVENRPFLS 278

Query: 311 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKC 363
           +L     S  D G Y C   +KLG+ +AS  I +    A S  + GTS    C
Sbjct: 279 KLIFFNVSEHDYGNYTCVASNKLGHTNAS--IMLFGPGAVSEVSNGTSRRAGC 329


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 50/186 (26%), Positives = 78/186 (41%), Gaps = 35/186 (18%)

Query: 249  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 308
            A P   ++++  E A G      CE  S   ++RF+WFK G E+   +K     I+    
Sbjct: 3454 AAPVIKRKIEPLEVALGHLAKFTCEIQSA-PNVRFQWFKAGREIYESDK---CSIRSSKY 3509

Query: 309  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVE-------SNATSTST------- 354
             S L I +  + D GEY CK  ++ G+ S +A +T+ E       S   S +T       
Sbjct: 3510 ISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAK 3569

Query: 355  -----TGTSHLVKCAEKE-------KTFCVNGGECFMVKDLSN-----PSRYLCKCPNEF 397
                 TGT  +    +K+         + ++  E   + +LSN        Y CK  N+F
Sbjct: 3570 FICTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKF 3629

Query: 398  TGDRCQ 403
              D CQ
Sbjct: 3630 GADICQ 3635



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 42/190 (22%), Positives = 76/190 (40%), Gaps = 34/190 (17%)

Query: 250  LPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 308
            +PP   K++   +   GS + + C+ S     +  +WFK+G E++   K + +  ++   
Sbjct: 5235 IPPSFTKKLTKMDKVLGSSIHMECKVSGSLP-ISAQWFKDGKEISTSAKYRLVCHERSVS 5293

Query: 309  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVE----------SNATSTSTTGTS 358
               L +N   L D+  Y CKV +  G+D+ S  +T+ E            A   ST    
Sbjct: 5294 ---LEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVKPGRQQAIPDSTVEFK 5350

Query: 359  HLVKCAE-------KEKTFCVNGGECFM------------VKDLSNPSRYLCKCPNEFTG 399
             ++K          K+    V+G +CF+              D S   +Y C   N+   
Sbjct: 5351 AILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGS 5410

Query: 400  DRCQNYVMAS 409
            D C   ++ +
Sbjct: 5411 DSCTTMLLVT 5420



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 31/118 (26%), Positives = 55/118 (46%), Gaps = 11/118 (9%)

Query: 236  LKKEVSRVLCKR------CALPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKN 288
            ++ +V R  CK         +PP   K++K  +S  GS + L C  +  +  +  +WFK+
Sbjct: 4653 VQNDVGRSSCKARINVLDLIIPPSFTKKLKKMDSIKGSFIDLECIVAGSHP-ISIQWFKD 4711

Query: 289  GNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346
              E++   K    K       + L I++    DSG Y C   +K G++  S ++T+ E
Sbjct: 4712 DQEISASEK---YKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKE 4766



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 27/100 (27%), Positives = 44/100 (44%), Gaps = 4/100 (4%)

Query: 247  RCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 306
            R   P   +++K     +GS +V+ C+       +   WF  GNE++   K Q       
Sbjct: 7678 RTVPPSFTRKLKETNGLSGSSVVMECKVYGS-PPISVSWFHEGNEISSGRKYQTTLTDNT 7736

Query: 307  PGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346
                 L +N    +DSG+Y C   +  G+D  SA +T+ E
Sbjct: 7737 ---CALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVRE 7773



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 28/95 (29%), Positives = 48/95 (50%), Gaps = 4/95 (4%)

Query: 251   PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310
             P  + + +SQ    G  ++  CE S E S    +WFKN   ++  +   N+ I +     
Sbjct: 33134 PAFISQPRSQNINEGQNVLFTCEISGEPSP-EIEWFKNNLPISISS---NVSISRSRNVY 33189

Query: 311   ELRINKASLADSGEYMCKVISKLGNDSASANITIV 345
              L I  AS++DSG+Y  K  +  G  SA+A++ ++
Sbjct: 33190 SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVL 33224



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 33/121 (27%), Positives = 57/121 (47%), Gaps = 5/121 (4%)

Query: 251  PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310
            P  +KE++  +SA   K+ L C+   +   +   W K+G +L      ++ KI  +   +
Sbjct: 3644 PHFIKELEPVQSAINKKVHLECQVDED-RKVTVTWSKDGQKLP---PGKDYKICFEDKIA 3699

Query: 311  ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTF 370
             L I  A L DSG Y+C   ++ G+ S SA +T+ E   +       S+L+   E  +  
Sbjct: 3700 TLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREP-PSFVKKVDPSYLMLPGESARLH 3758

Query: 371  C 371
            C
Sbjct: 3759 C 3759



 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 42/186 (22%), Positives = 72/186 (38%), Gaps = 33/186 (17%)

Query: 251  PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310
            P  ++E+K  E    S + L CE +         W KN  E+    K     +  +    
Sbjct: 4955 PTFIRELKPVEVVKYSDVELECEVTGT-PPFEVTWLKNNREIRSSKK---YTLTDRVSVF 5010

Query: 311  ELRINKASLADSGEYMCKVISKLGNDSASANI----------------TIVESNATSTST 354
             L I K   +D+GEY C V ++ G+ S S  +                T+++S+AT  ST
Sbjct: 5011 NLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQST 5070

Query: 355  TGTSHLVKCA---------EKEKTFC--VNGGECFMVKDLSN--PSRYLCKCPNEFTGDR 401
               S  +            E +  +   V+      ++ + N    RY C+  NE   +R
Sbjct: 5071 VAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVER 5130

Query: 402  CQNYVM 407
            C  +++
Sbjct: 5131 CYAFLL 5136



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 29/96 (30%), Positives = 53/96 (55%), Gaps = 6/96 (6%)

Query: 251  PPR-LKEMKSQESAA-GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 308
            PP+ +K++++ + A  G  + L C+ S     ++  WF+N +EL+   K     I     
Sbjct: 6363 PPKFVKKLEASKVAKQGESIQLECKISGS-PEIKVSWFRNDSELHESWKYNMSFINSV-- 6419

Query: 309  KSELRINKASLADSGEYMCKVISKLGNDSASANITI 344
             + L IN+AS  DSG+Y+C+  + +G+ S S  +T+
Sbjct: 6420 -ALLTINEASAEDSGDYICEAHNGVGDASCSTALTV 6454



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 27/78 (34%), Positives = 40/78 (51%), Gaps = 10/78 (12%)

Query: 267   KLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM 326
             ++ L+CE S +   +  KWFK+G E+    K     I+    +  L+I KA L D GEY+
Sbjct: 11679 EITLKCEVSKD---VPVKWFKDGEEIVPSPK---YSIKADGLRRILKIKKADLKDKGEYV 11732

Query: 327   CKVISKLGNDSASANITI 344
             C      G D   AN+T+
Sbjct: 11733 C----DCGTDKTKANVTV 11746



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 24/89 (26%), Positives = 45/89 (50%), Gaps = 9/89 (10%)

Query: 281  LRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASA 340
            ++  WFKN  EL+  N    +++     ++ L I    + DSG Y C+ ++ +G+DS S 
Sbjct: 3767 IQVTWFKNNKELSESN---TVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCST 3823

Query: 341  NITI------VESNATSTSTTGTSHLVKC 363
             I I      +++   +    GT+ L++C
Sbjct: 3824 EIVIKEPPSFIKTLEPADIVRGTNALLQC 3852



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 31/112 (27%), Positives = 49/112 (43%), Gaps = 5/112 (4%)

Query: 251  PPRLKEMKSQESAA-GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 309
            PP   +  S   A  GS ++L+CE S         W K+  ++    K    KI  K   
Sbjct: 6457 PPVFTQKPSPVGALKGSDVILQCEISGT-PPFEVVWVKDRKQVRNSKK---FKITSKHFD 6512

Query: 310  SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLV 361
            + L I     +D GEY CK  +++G+D+ S ++   E        + TS L+
Sbjct: 6513 TSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKLSDTSTLI 6564



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 27/115 (23%), Positives = 52/115 (45%), Gaps = 5/115 (4%)

Query: 241  SRVLCKRCALPPRLKEMKSQESAA-GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQ 299
            S ++ K    PP   +  +  + + G  + L C        +R +W K G E+   ++  
Sbjct: 8335 SSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGS-EPIRIQWLKAGREIKPSDR-- 8391

Query: 300  NIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST 354
                    G + L +   + ADSG+Y+CK  +  G+D+  + +TI +  A + +T
Sbjct: 8392 -CSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPAT 8445



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 40/193 (20%), Positives = 75/193 (38%), Gaps = 33/193 (17%)

Query: 239  EVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKP 298
            E +  +  R   P   K +++ +S       L C+ +     +R  WFK+G E+   ++ 
Sbjct: 4101 ETTFTVLDRDIAPFFTKPLRNVDSVVNGTCRLDCKIAGSLP-MRVSWFKDGKEIAASDR- 4158

Query: 299  QNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE------------ 346
               +I    G + L I +  + D+G + C+  + +G+  +S  + + E            
Sbjct: 4159 --YRIAFVEGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKD 4216

Query: 347  ---SNATSTSTT--GTSHLVKCAEKEKTFCVNGGECFMVKD------------LSNPSRY 389
                +A    +T  G++ L     K     V+GG C++ K+             S+   Y
Sbjct: 4217 VLPGSAVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTY 4276

Query: 390  LCKCPNEFTGDRC 402
             CK  N   G  C
Sbjct: 4277 TCKVSNVAGGVEC 4289



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 34/140 (24%), Positives = 58/140 (41%), Gaps = 35/140 (25%)

Query: 209  MEPDANSTSRAPAAFRASFPPLETGRNLKK-EVSRVLCKRCALPPRLKEMKSQESAAGSK 267
            +E  AN   + PA F      LE  + LKK + +++ CK    PP               
Sbjct: 4287 VECSANLFVKEPATF---VEKLEPSQLLKKGDATQLACKVTGTPP--------------- 4328

Query: 268  LVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMC 327
                         ++  WF N  E+   +K +   ++     + LR+    + DSGEYMC
Sbjct: 4329 -------------IKITWFANDREIKESSKHRMSFVEST---AVLRLTDVGIEDSGEYMC 4372

Query: 328  KVISKLGNDSASANITIVES 347
            +  ++ G+D  S+ + + ES
Sbjct: 4373 EAQNEAGSDHCSSIVIVKES 4392



 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 41/179 (22%), Positives = 68/179 (37%), Gaps = 34/179 (18%)

Query: 259  SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKAS 318
            S++   GS + L+  T    + L  +WFK   EL       +  I K+  +S L +    
Sbjct: 4214 SKDVLPGSAVCLK-STFQGSTPLTIRWFKGNKELVSGG---SCYITKEALESSLELYLVK 4269

Query: 319  LADSGEYMCKVISKLGNDSASANITIVE------------------SNATSTSTTGTSHL 360
             +DSG Y CKV +  G    SAN+ + E                  +   +   TGT  +
Sbjct: 4270 TSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQLLKKGDATQLACKVTGTPPI 4329

Query: 361  ----------VKCAEKEKTFCVNGGECFMVKD--LSNPSRYLCKCPNEFTGDRCQNYVM 407
                      +K + K +   V       + D  + +   Y+C+  NE   D C + V+
Sbjct: 4330 KITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVI 4388



 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 28/107 (26%), Positives = 50/107 (46%), Gaps = 4/107 (3%)

Query: 240  VSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQ 299
            VS  +  R   P  ++++K   +  G+ +VL C  S   + +   WF++GNE+    K Q
Sbjct: 6730 VSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVSGS-APISVGWFQDGNEIVSGPKCQ 6788

Query: 300  NIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346
            +           L ++    +D+G Y C   +  G+D  SA +T+ E
Sbjct: 6789 S---SFSENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQE 6832



 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 32/119 (26%), Positives = 57/119 (47%), Gaps = 13/119 (10%)

Query: 254  LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 313
            +++ +S +   G    L C T +    L  KWFK+G EL   NK +     K  G   L+
Sbjct: 7589 VEKPESIKVTTGDTCTLEC-TVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSG---LK 7644

Query: 314  INKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST---------TGTSHLVKC 363
            I   + +DSG Y  +V + +G DS +A++ + +     + T         +G+S +++C
Sbjct: 7645 IINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMEC 7703



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 27/94 (28%), Positives = 47/94 (50%), Gaps = 4/94 (4%)

Query: 251  PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310
            P  ++ ++  E+  G    L+C+       +R  W+K   +L  ++ P   K+Q K   +
Sbjct: 7020 PYFIEPLEHVEAVIGEPATLQCKVDGT-PEIRISWYKEHTKL--RSAPA-YKMQFKNNVA 7075

Query: 311  ELRINKASLADSGEYMCKVISKLGNDSASANITI 344
             L INK   +D GEY CK  + +G  ++SA + I
Sbjct: 7076 SLVINKVDHSDVGEYSCKADNSVGAVASSAVLVI 7109



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 26/98 (26%), Positives = 48/98 (48%), Gaps = 5/98 (5%)

Query: 250  LPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 308
            LPP   +++K  E   G  + L C  +   + ++  W+++G  L      +N++      
Sbjct: 6173 LPPSFARQLKDIEQTVGLPVTLTCRLNGS-APIQVCWYRDGVLLR---DDENLQTSFVDN 6228

Query: 309  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346
             + L+I +  L+ SG+Y C   + LG  S+SA +T  E
Sbjct: 6229 VATLKILQTDLSHSGQYSCSASNPLGTASSSARLTARE 6266



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 24/96 (25%), Positives = 46/96 (47%), Gaps = 4/96 (4%)

Query: 251  PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310
            P  +K+++  + + G    L+C+ +     +   W+K   +L         K+  +   +
Sbjct: 7961 PYFVKQLEPVKVSVGDSASLQCQLAGT-PEIGVSWYKGDTKLRPTT---TYKMHFRNNVA 8016

Query: 311  ELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346
             L  N+  + DSGEY+CK  + +G  SAS  +T+ E
Sbjct: 8017 TLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQE 8052



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 29/120 (24%), Positives = 56/120 (46%), Gaps = 10/120 (8%)

Query: 251  PPR-LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 309
            PPR +K++    +  G  + LR      +  +   W K+  E+ R++  +N +I      
Sbjct: 6550 PPRFVKKLSDTSTLIGDAVELRAIVEG-FQPISVVWLKDRGEVIRES--ENTRISFIDNI 6606

Query: 310  SELRINKASLADSGEYMCKVISKLGNDSASANIT------IVESNATSTSTTGTSHLVKC 363
            + L++     ++SG+Y+C++ +  G    SA +T      I+E     T TTG    ++C
Sbjct: 6607 ATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALEC 6666



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 31/119 (26%), Positives = 52/119 (43%), Gaps = 8/119 (6%)

Query: 251  PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310
            PPR  +  S  S    K V    T      +   WFK+  E+ R++   NI I      +
Sbjct: 7491 PPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRES--DNIWISYSENIA 7548

Query: 311  ELRINKASLADSGEYMCKVISKLGNDSASANI------TIVESNATSTSTTGTSHLVKC 363
             L+ ++   A++G+Y C++ +  G     A +      TIVE   +   TTG +  ++C
Sbjct: 7549 TLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLEC 7607



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 33/133 (24%), Positives = 53/133 (39%), Gaps = 9/133 (6%)

Query: 214  NSTSRAPAAFRASFPPLETGRNLKKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCE 273
            NST R    +       E GR    +V   L      P  + E++  E+A G  + L+C+
Sbjct: 6047 NSTKRDAGQYSCEIEN-EAGR----DVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQ 6101

Query: 274  TSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKL 333
             +     +   W+K   +L         +       + L  NK ++ DSGEY CK  + +
Sbjct: 6102 VAGT-PEITVSWYKGDTKLR---PTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSI 6157

Query: 334  GNDSASANITIVE 346
            G  S+     I E
Sbjct: 6158 GTASSKTVFRIQE 6170



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 24/105 (22%), Positives = 46/105 (43%), Gaps = 4/105 (3%)

Query: 261  ESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLA 320
            ++  G      C  +     ++  W K+  E+    K Q   ++     + L+++K    
Sbjct: 8163 DAVVGESADFECHVTGT-QPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKG--- 8218

Query: 321  DSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAE 365
            DSG+Y C  ++++G DS +A + I E     + T   S  V+  E
Sbjct: 8219 DSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETE 8263



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 30/109 (27%), Positives = 47/109 (43%), Gaps = 8/109 (7%)

Query: 245   CKRCALPPRLKEMKS-QESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 303
             C    +PP ++ ++   +     K + R E      + + KWFK+G E+ +  K     I
Sbjct: 12365 CNLNVVPPHVEFLRPLTDLQVREKEMARFECELSRENAKVKWFKDGAEIKKGKK---YDI 12421

Query: 304   QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATST 352
               K     L INK  L D  EY C+V +       S  +T++E  A  T
Sbjct: 12422 ISKGAVRILVINKCLLDDEAEYSCEVRTA----RTSGMLTVLEEEAVFT 12466



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 28/120 (23%), Positives = 49/120 (40%), Gaps = 6/120 (5%)

Query: 251  PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310
            P  +  +K+     G  + L C  S  Y S    W++   ++       + +I  + G +
Sbjct: 943  PTLVSGLKNVTVIEGESVTLECHISG-YPSPTVTWYREDYQIESSI---DFQITFQSGIA 998

Query: 311  ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTF 370
             L I +A   DSG + C  +++ G  S S  + +  S      TT  +   K   +EK F
Sbjct: 999  RLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE--KFTTEEKRF 1056



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 25/79 (31%), Positives = 39/79 (49%), Gaps = 6/79 (7%)

Query: 285   WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT- 343
             W K+G  + +  K    K+ +  G   L I+K   +DSG Y C V +  G+ S+S  +T 
Sbjct: 32885 WTKDGKAITQGGK---YKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 32941

Query: 344   --IVESNATSTSTTGTSHL 360
               I ++ A   ST  TS +
Sbjct: 32942 KAIKDTEAQKVSTQKTSEI 32960



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 23/63 (36%), Positives = 32/63 (50%), Gaps = 3/63 (4%)

Query: 284  KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 343
            KWFK+G EL   +K    KI      S L+I      DSGEY  +V + +G  S  A I 
Sbjct: 4611 KWFKDGQELTLGSK---YKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARIN 4667

Query: 344  IVE 346
            +++
Sbjct: 4668 VLD 4670



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 25/98 (25%), Positives = 51/98 (52%), Gaps = 6/98 (6%)

Query: 251  PPR-LKEMKSQESA-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 308
            PP+ +K++++ +   AG    L C+ +     +R  WF+N +EL   +K +   I     
Sbjct: 5422 PPKFVKKLEASKIVKAGDSSRLECKIAGS-PEIRVVWFRNEHELPASDKYRMTFIDSV-- 5478

Query: 309  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346
             + +++N  S  DSG+++C+  +  G+ S S  + + E
Sbjct: 5479 -AVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKE 5515



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 23/84 (27%), Positives = 37/84 (44%), Gaps = 4/84 (4%)

Query: 261  ESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLA 320
            E+  G+ + L CE           W+K+  EL    K    KI  +   + + I     A
Sbjct: 7409 ETLKGADVHLECELQGT-PPFHVSWYKDKRELRSGKK---YKIMSENFLTSIHILNVDAA 7464

Query: 321  DSGEYMCKVISKLGNDSASANITI 344
            D GEY CK  + +G+D+   +I +
Sbjct: 7465 DIGEYQCKATNDVGSDTCVGSIAL 7488



 Score = 38.1 bits (87), Expect = 0.015
 Identities = 31/106 (29%), Positives = 47/106 (44%), Gaps = 4/106 (3%)

Query: 255  KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 314
            KE K  E      ++L  E +         WFK+ N + R  +     IQ       L+I
Sbjct: 4397 KEFKPIEVLKEYDVMLLAEVAGT-PPFEITWFKD-NTILRSGRKYKTFIQDH--LVSLQI 4452

Query: 315  NKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHL 360
             K   AD+GEY C+V +++G+   SA +T+ E  +       TS L
Sbjct: 4453 LKFVAADAGEYQCRVTNEVGSSICSARVTLREPPSFIKKIESTSSL 4498



 Score = 38.1 bits (87), Expect = 0.015
 Identities = 25/98 (25%), Positives = 44/98 (44%), Gaps = 10/98 (10%)

Query: 249  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 308
            + PP ++ +K+ E +      L CE S         W+K+  +L    K    KI  K  
Sbjct: 5521 SFPPIVETLKNAEVS------LECELSGT-PPFEVVWYKDKRQLRSSKK---YKIASKNF 5570

Query: 309  KSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346
             + + I     +D GEY CK  +++G+D+    + + E
Sbjct: 5571 HTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKE 5608



 Score = 37.7 bits (86), Expect = 0.020
 Identities = 18/70 (25%), Positives = 31/70 (44%)

Query: 285   WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 344
             W+K+G ++   +  +    +   G  +L IN  +  D  EY     +K G DS  A +T+
Sbjct: 31723 WYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 31782

Query: 345   VESNATSTST 354
                   + ST
Sbjct: 31783 TLHPPPTDST 31792



 Score = 37.7 bits (86), Expect = 0.020
 Identities = 46/197 (23%), Positives = 80/197 (40%), Gaps = 21/197 (10%)

Query: 150   SAGEPGEEAPYLVKVHQVWAVKAGGLKKDSLLTVRLGTWGHPAFPSCGRLKEDSRYIFFM 209
             S+ +  +E  Y V V        G  + +  LT++       A  S  R+K     +   
Sbjct: 32621 SSVQASDEGNYSVVVEN----SEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRV--K 32674

Query: 210   EPDANSTSRAPAAFRASFP----PLETGRNLKKEVSRVLCKRCALPPRLKEMKSQESAAG 265
              P+A  + +   +   S P    P ET     ++V  +     + PP++ +    E+   
Sbjct: 32675 SPEAVKSPKRVKSPEPSHPKAVSPTETKPTPTEKVQHL---PVSAPPKITQFLKAEA--- 32728

Query: 266   SKLVLRCETSSEYSSLRFK---WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADS 322
             SK + +     E S LR K   W+K+G +L      Q        G  EL+IN  + +D 
Sbjct: 32729 SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH--YSADGTYELKINNLTESDQ 32786

Query: 323   GEYMCKVISKLGNDSAS 339
             GEY+C++  + G    +
Sbjct: 32787 GEYVCEISGEGGTSKTN 32803



 Score = 37.4 bits (85), Expect = 0.026
 Identities = 23/83 (27%), Positives = 34/83 (40%), Gaps = 4/83 (4%)

Query: 264  AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSG 323
            AG      C  +     +R  W K+  E+       N  I        LRI K    DSG
Sbjct: 6284 AGESADFECHVTGA-QPMRITWSKDNKEIRPGG---NYTITCVGNTPHLRILKVGKGDSG 6339

Query: 324  EYMCKVISKLGNDSASANITIVE 346
            +Y C+  + +G D  SA +++ E
Sbjct: 6340 QYTCQATNDVGKDMCSAQLSVKE 6362



 Score = 37.4 bits (85), Expect = 0.026
 Identities = 27/103 (26%), Positives = 46/103 (44%), Gaps = 6/103 (5%)

Query: 246  KRCALPPRLKEMKSQ--ESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 303
            K   +PP   +  S+  E   G+   L    +     +   W+KN  E+   +   N +I
Sbjct: 8243 KERLIPPSFTKRLSETVEETEGNSFKLEGRVAGS-QPITVAWYKNNIEIQPTS---NCEI 8298

Query: 304  QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346
              K     L++ KA + D+G Y CKV +  G+   +++I I E
Sbjct: 8299 TFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKE 8341



 Score = 35.8 bits (81), Expect = 0.075
 Identities = 32/128 (25%), Positives = 56/128 (43%), Gaps = 14/128 (10%)

Query: 248  CALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLR------FKWFKNGNELNRKNKPQNI 301
            C    +LKE     S   S  V+  E +   +S+        +W K   E+ R++  +NI
Sbjct: 5600 CVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRES--ENI 5657

Query: 302  KIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANI------TIVESNATSTSTT 355
            +I      + L+  KA  A++G+Y+C++ +  G     A +       IVE     T T 
Sbjct: 5658 RITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTV 5717

Query: 356  GTSHLVKC 363
            G +  ++C
Sbjct: 5718 GETCTLEC 5725



 Score = 35.4 bits (80), Expect = 0.098
 Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 4/80 (5%)

Query: 265  GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGE 324
            G+   L C  +     L  KWFK+G EL+  +K     I K    + L+I  A ++D G 
Sbjct: 6659 GNPFALECVVTGT-PELSAKWFKDGRELSADSKHHITFINK---VASLKIPCAEMSDKGL 6714

Query: 325  YMCKVISKLGNDSASANITI 344
            Y  +V + +G  + + ++ +
Sbjct: 6715 YSFEVKNSVGKSNCTVSVHV 6734



 Score = 35.4 bits (80), Expect = 0.098
 Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 2/43 (4%)

Query: 255   KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNK 297
             K ++ Q    G+  VL CE S E  + + KWFKNG E+ +  K
Sbjct: 12289 KPLEDQTVEEGATAVLECEVSRE--NAKVKWFKNGTEILKSKK 12329



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 26/96 (27%), Positives = 43/96 (44%), Gaps = 4/96 (4%)

Query: 251  PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310
            P  +K ++  +   G+  +L+CE S         WFK+  ++ R +K   +  QK     
Sbjct: 3831 PSFIKTLEPADIVRGTNALLQCEVSGT-GPFEISWFKDKKQI-RSSKKYRLFSQKS--LV 3886

Query: 311  ELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346
             L I   + AD GEY C V +++G     A   + E
Sbjct: 3887 CLEIFSFNSADVGEYECVVANEVGKCGCMATHLLKE 3922



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 25/93 (26%), Positives = 40/93 (43%), Gaps = 4/93 (4%)

Query: 254  LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 313
            +K +       G  L+L   T +    +   W KNG  +      Q   I      + L 
Sbjct: 7871 VKRLNDYSIEKGKPLILE-GTFTGTPPISVTWKKNGINVTPS---QRCNITTTEKSAILE 7926

Query: 314  INKASLADSGEYMCKVISKLGNDSASANITIVE 346
            I  +++ D+G+Y C + +  G DS SA I I+E
Sbjct: 7927 IPSSTVEDAGQYNCYIENASGKDSCSAQILILE 7959



 Score = 34.3 bits (77), Expect = 0.22
 Identities = 23/99 (23%), Positives = 41/99 (41%), Gaps = 5/99 (5%)

Query: 249  ALPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKP 307
            A+PP   + +K+     G+  +L C+ +   S +   WF    ++    K Q        
Sbjct: 5797 AVPPSFTRRLKNTGGVLGASCILECKVAGS-SPISVAWFHEKTKIVSGAKYQTTF---SD 5852

Query: 308  GKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346
                L++N    +D G Y C   +  G+D   A +T+ E
Sbjct: 5853 NVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQE 5891



 Score = 34.3 bits (77), Expect = 0.22
 Identities = 28/117 (23%), Positives = 46/117 (39%), Gaps = 5/117 (4%)

Query: 259  SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKAS 318
            S + A G     +C  +   + ++  W K+  E+       N K+      + L + K  
Sbjct: 7220 SVDLALGESGTFKCHVTGT-APIKITWAKDNREIRPGG---NYKMTLVENTATLTVLKVG 7275

Query: 319  LADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGG 375
              D+G+Y C   +  G DS SA + + E           S +VK  E  +  C  GG
Sbjct: 7276 KGDAGQYTCYASNIAGKDSCSAQLGVQEP-PRFIKKLEPSRIVKQDEFTRYECKIGG 7331



 Score = 33.9 bits (76), Expect = 0.29
 Identities = 29/103 (28%), Positives = 43/103 (41%), Gaps = 7/103 (6%)

Query: 255  KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 314
            K +  Q  A   + V  CE ++  S  + +W ++G  L   N   NI+ +    K  L I
Sbjct: 2624 KPLTDQTVAESQEAVFECEVANPDS--KGEWLRDGKHLPLTN---NIRSESDGHKRRLII 2678

Query: 315  NKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGT 357
                L D GEY  KV +     SA   +  V+   T  + T T
Sbjct: 2679 AATKLDDIGEYTYKVAT--SKTSAKLKVEAVKIKKTLKNLTVT 2719



 Score = 33.9 bits (76), Expect = 0.29
 Identities = 27/99 (27%), Positives = 41/99 (41%), Gaps = 5/99 (5%)

Query: 249  ALPPR-LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKP 307
            A PP  L   KS  +  G      C T +    +   W K+G  L+      N +I    
Sbjct: 3548 AYPPTFLSRPKSLTTFVGKAAKFIC-TVTGTPVIETIWQKDGAALSPS---PNWRISDAE 3603

Query: 308  GKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346
             K  L ++  ++ D G Y CK  +K G D   A + I++
Sbjct: 3604 NKHILELSNLTIQDRGVYSCKASNKFGADICQAELIIID 3642



 Score = 33.5 bits (75), Expect = 0.37
 Identities = 21/96 (21%), Positives = 46/96 (47%), Gaps = 4/96 (4%)

Query: 251  PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310
            P  +++ +SQ+    +++ L+       + +  KWFK+  EL+         + K    +
Sbjct: 4768 PYFVEKPQSQDVNPNTRVQLKALVGGT-APMTIKWFKDNKELHSGAARS---VWKDDTST 4823

Query: 311  ELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346
             L +  A   DSG Y+C++ + +G  ++ A + + E
Sbjct: 4824 SLELFAAKATDSGTYICQLSNDVGTATSKATLFVKE 4859



 Score = 33.5 bits (75), Expect = 0.37
 Identities = 30/121 (24%), Positives = 49/121 (40%), Gaps = 5/121 (4%)

Query: 265  GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGE 324
            G      C+ +     +R  W+ +GNE+    K     I    G +  +I+ A + +SG 
Sbjct: 4876 GQSTTFECQITGT-PKIRVSWYLDGNEITAIQKHG---ISFIDGLATFQISGARVENSGT 4931

Query: 325  YMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLS 384
            Y+C+  +  G  S S  + + E   T         +VK ++ E    V G   F V  L 
Sbjct: 4932 YVCEARNDAGTASCSIELKVKEP-PTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLK 4990

Query: 385  N 385
            N
Sbjct: 4991 N 4991



 Score = 33.5 bits (75), Expect = 0.37
 Identities = 18/73 (24%), Positives = 33/73 (45%), Gaps = 3/73 (4%)

Query: 272   CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 331
             C+  +   S +  W+    +L    K    +I  + G + L +   +  D G Y CKV++
Sbjct: 31589 CKIENYDQSTQVTWYFGVRQLENSEK---YEITYEDGVAILYVKDITKLDDGTYRCKVVN 31645

Query: 332   KLGNDSASANITI 344
               G DS+ A + +
Sbjct: 31646 DYGEDSSYAELFV 31658



 Score = 33.5 bits (75), Expect = 0.37
 Identities = 36/147 (24%), Positives = 57/147 (38%), Gaps = 15/147 (10%)

Query: 210   EPDANSTSRAPAAFRASFPPLETGRNLKKEVS-RVLCKRCALPPRLKEMKSQESAAGSKL 268
             E  A++  ++ A    S     T R +K  ++ R+L K     PR   +   ESA  S  
Sbjct: 32529 EHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTK-----PRSMTVYEGESARFS-- 32581

Query: 269   VLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCK 328
                C+T  E       W + G  L+   + Q   +     KS   I+    +D G Y   
Sbjct: 32582 ---CDTDGEPVPT-VTWLRKGQVLSTSARHQ---VTTTKYKSTFEISSVQASDEGNYSVV 32634

Query: 329   VISKLGNDSASANITIVESNATSTSTT 355
             V +  G   A   +TI ++  T  + T
Sbjct: 32635 VENSEGKQEAEFTLTIQKARVTEKAVT 32661



 Score = 33.1 bits (74), Expect = 0.49
 Identities = 26/101 (25%), Positives = 41/101 (40%), Gaps = 25/101 (24%)

Query: 254  LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 313
            LK++ ++E     K  +  E +  Y  + +KW KNG E+   +K Q   ++ K     L 
Sbjct: 2975 LKDINAEE-----KDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQ---MRTKKLTHSLN 3026

Query: 314  INKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST 354
            I      D+ +Y                 T V   ATST+T
Sbjct: 3027 IRNVHFGDAADY-----------------TFVAGKATSTAT 3050



 Score = 33.1 bits (74), Expect = 0.49
 Identities = 26/96 (27%), Positives = 44/96 (45%), Gaps = 11/96 (11%)

Query: 254   LKEMK----SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 309
             +KE+K    ++    GS  +  C  S   S+    W K+G+ +    K + I   K    
Sbjct: 11118 VKEIKDIILTESEFVGSSAIFECLVSP--STAITTWMKDGSNIRESPKHRFIADGKD--- 11172

Query: 310   SELRINKASLADSGEYMCKVISKLGNDSASANITIV 345
              +L I    L+D+GEY C  + +LGN   ++   +V
Sbjct: 11173 RKLHIIDVQLSDAGEYTC--VLRLGNKEKTSTAKLV 11206



 Score = 32.7 bits (73), Expect = 0.64
 Identities = 15/66 (22%), Positives = 35/66 (53%), Gaps = 3/66 (4%)

Query: 281  LRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASA 340
            ++  W+K+  E+   +K    ++      + L ++  S+ DSG+Y C+  +  G+ S+S 
Sbjct: 7335 IKVLWYKDETEIQESSK---FRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSST 7391

Query: 341  NITIVE 346
            ++ + E
Sbjct: 7392 SLKVKE 7397



 Score = 32.7 bits (73), Expect = 0.64
 Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 5/76 (6%)

Query: 254   LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 313
             ++ ++ Q        V  C+ S E +++  KW++NG E+    K    K +K      L 
Sbjct: 12826 VEHLEDQTVTEFDDAVFSCQLSREKANV--KWYRNGREIKEGKK---YKFEKDGSIHRLI 12880

Query: 314   INKASLADSGEYMCKV 329
             I    L D  EY C V
Sbjct: 12881 IKDCRLDDECEYACGV 12896



 Score = 32.7 bits (73), Expect = 0.64
 Identities = 16/61 (26%), Positives = 34/61 (55%), Gaps = 3/61 (4%)

Query: 285   WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 344
             W K+G E+   ++   + ++     + L + K+  AD+G Y   + +KLG+ +AS N+ +
Sbjct: 14420 WHKDGKEVKASDR---LTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKV 14476

Query: 345   V 345
             +
Sbjct: 14477 I 14477



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 23/83 (27%), Positives = 38/83 (45%), Gaps = 2/83 (2%)

Query: 260  QESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASL 319
            Q+   G  +V  C+         + W K+G  L    +   +   K+ G+ +L I+    
Sbjct: 1091 QKLVEGGSVVFGCQVGGNPKPHVY-WKKSGVPLTTGYR-YKVSYNKQTGECKLVISMTFA 1148

Query: 320  ADSGEYMCKVISKLGNDSASANI 342
             D+GEY   V +K G  SASA++
Sbjct: 1149 DDAGEYTIVVRNKHGETSASASL 1171



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 23/94 (24%), Positives = 39/94 (41%), Gaps = 4/94 (4%)

Query: 282  RFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASAN 341
            + KWFK+  EL    K     I  +   S L +     + +G+Y C V + +G+DS +  
Sbjct: 5360 KIKWFKDDVELVSGPK---CFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTM 5416

Query: 342  ITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGG 375
            + + E           S +VK  +  +  C   G
Sbjct: 5417 LLVTEP-PKFVKKLEASKIVKAGDSSRLECKIAG 5449



 Score = 31.6 bits (70), Expect = 1.4
 Identities = 28/100 (28%), Positives = 44/100 (44%), Gaps = 10/100 (10%)

Query: 247   RCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 306
             R  +P +   +K Q+     ++V  CE ++E    + KWF+N   +   +K     I +K
Sbjct: 12641 RIVVPLKDTRVKEQQ-----EVVFNCEVNTE--GAKAKWFRNEEAIFDSSK---YIILQK 12690

Query: 307   PGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346
                  LRI  A L D   Y   + +  G +  SA   IVE
Sbjct: 12691 DLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVE 12730



 Score = 30.8 bits (68), Expect = 2.4
 Identities = 20/93 (21%), Positives = 40/93 (43%), Gaps = 4/93 (4%)

Query: 254  LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 313
            LK +       G  ++L   T +    +   W K+G  +    K   +  +K      L 
Sbjct: 5989 LKRLSDHSVEPGKSIILE-STYTGTLPISVTWKKDGFNITTSEKCNIVTTEKT---CILE 6044

Query: 314  INKASLADSGEYMCKVISKLGNDSASANITIVE 346
            I  ++  D+G+Y C++ ++ G D   A ++ +E
Sbjct: 6045 ILNSTKRDAGQYSCEIENEAGRDVCGALVSTLE 6077



 Score = 30.8 bits (68), Expect = 2.4
 Identities = 17/65 (26%), Positives = 32/65 (49%), Gaps = 3/65 (4%)

Query: 282  RFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASAN 341
            + KWFK   EL      ++  I  +   +EL + +    +SG+Y C V +  G+ S + +
Sbjct: 6864 KVKWFKGSRELV---PGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTH 6920

Query: 342  ITIVE 346
            + + E
Sbjct: 6921 LFVKE 6925



 Score = 30.8 bits (68), Expect = 2.4
 Identities = 33/143 (23%), Positives = 60/143 (41%), Gaps = 8/143 (5%)

Query: 208   FMEPDANSTSRAPAAF----RASFPPLETGRNLKKEVSRVLCKRC-ALPPRLKEMKSQES 262
             F    A S S    +F     +SF  +     L+   S++L      +PP+++ + S  S
Sbjct: 33280 FASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDIS 33339

Query: 263   A-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLAD 321
                G  L + C  + E +     W   G +++ + + +   I+     + L I      D
Sbjct: 33340 IDEGKVLTVACAFTGEPTP-EVTWSCGGRKIHSQEQGR-FHIENTDDLTTLIIMDVQKQD 33397

Query: 322   SGEYMCKVISKLGNDSASANITI 344
              G Y   + ++ G+DSA+ NI I
Sbjct: 33398 GGLYTLSLGNEFGSDSATVNIHI 33420



 Score = 30.4 bits (67), Expect = 3.2
 Identities = 43/193 (22%), Positives = 67/193 (34%), Gaps = 40/193 (20%)

Query: 265  GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGE 324
            G    L C+ +     L  +W+K+G  L    K +     K    S LRI      D+G 
Sbjct: 5718 GETCTLECKVAGT-PELSVEWYKDGKLLTSSQKHKFSFYNKI---SSLRILSVERQDAGT 5773

Query: 325  YMCKVISKLGNDSASANITIVESNATSTST---------TGTSHLVKCAE---------- 365
            Y  +V + +G  S +A + + +     + T          G S +++C            
Sbjct: 5774 YTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAW 5833

Query: 366  -KEKTFCVNGGE---------CFM---VKDLSNPSRYLCKCPNEFTGDRCQNYVMA---- 408
              EKT  V+G +         C +     D S+   Y C   N    D C+  +      
Sbjct: 5834 FHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPP 5893

Query: 409  SFYSTSTPFLSLP 421
            SF     P   LP
Sbjct: 5894 SFVKEPEPLEVLP 5906



 Score = 30.4 bits (67), Expect = 3.2
 Identities = 17/68 (25%), Positives = 31/68 (45%), Gaps = 3/68 (4%)

Query: 282  RFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASAN 341
            +  WF+   EL + ++     I  +   +EL +    ++ SGEY C V +  G  S +  
Sbjct: 5923 KVNWFRGARELVKGDR---CNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTR 5979

Query: 342  ITIVESNA 349
            + + E  A
Sbjct: 5980 LFVKEPAA 5987



 Score = 29.6 bits (65), Expect = 5.4
 Identities = 16/63 (25%), Positives = 31/63 (49%), Gaps = 2/63 (3%)

Query: 284  KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 343
            KW K   +  + N+   + I +K  +++L I   +  DSG Y C   ++ G   ++ N+ 
Sbjct: 8486 KWTKG--KWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQ 8543

Query: 344  IVE 346
            + E
Sbjct: 8544 VDE 8546



 Score = 29.6 bits (65), Expect = 5.4
 Identities = 14/62 (22%), Positives = 31/62 (50%), Gaps = 1/62 (1%)

Query: 285   WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 344
             W K+ +  +    P+ +KI  +   S+  + KA  +D G+Y+    +  G+  A A + +
Sbjct: 18235 WTKDKDATDLTRSPR-VKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNV 18293

Query: 345   VE 346
             ++
Sbjct: 18294 LD 18295



 Score = 29.6 bits (65), Expect = 5.4
 Identities = 21/84 (25%), Positives = 36/84 (42%), Gaps = 5/84 (5%)

Query: 264   AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNI-KIQKKPGKSELRINKASLADS 322
             AG  +VL   +       +  W K G ++    +P +I +I   P  S L I  A+  D+
Sbjct: 20392 AGDTIVLNAISILGKPLPKSSWSKAGKDI----RPSDITQITSTPTSSMLTIKYATRKDA 20447

Query: 323   GEYMCKVISKLGNDSASANITIVE 346
             GEY     +  G       +T+++
Sbjct: 20448 GEYTITATNPFGTKVEHVKVTVLD 20471



 Score = 29.3 bits (64), Expect = 7.0
 Identities = 19/71 (26%), Positives = 33/71 (46%), Gaps = 5/71 (7%)

Query: 255  KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 314
            K +K  +     + +  CE S     +  +W K+  EL   ++   IKIQK+     L I
Sbjct: 3062 KHIKDIKVLEKKRAMFECEVSEP--DITVQWMKDDQELQITDR---IKIQKEKYVHRLLI 3116

Query: 315  NKASLADSGEY 325
                ++D+G+Y
Sbjct: 3117 PSTRMSDAGKY 3127



 Score = 29.3 bits (64), Expect = 7.0
 Identities = 16/60 (26%), Positives = 29/60 (48%), Gaps = 3/60 (5%)

Query: 285  WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 344
            WFK  +EL   ++     +  +   +EL +     + SGEY C V ++ G  S + ++ I
Sbjct: 7808 WFKGSSELVPGDR---CNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYI 7864



 Score = 28.9 bits (63), Expect = 9.2
 Identities = 16/66 (24%), Positives = 29/66 (43%), Gaps = 3/66 (4%)

Query: 284  KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 343
            +W  +G  L   N+   +++  + G   L    A   DSG   C+  +K G D  SA + 
Sbjct: 1737 EWLHDGKPLEAANR---LRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLI 1793

Query: 344  IVESNA 349
            + +  +
Sbjct: 1794 VKDEKS 1799



 Score = 28.9 bits (63), Expect = 9.2
 Identities = 26/116 (22%), Positives = 47/116 (40%), Gaps = 5/116 (4%)

Query: 233   GRNLKKEVSRVL-CKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNE 291
             G +L +E   V   K   LPP++   +     AG KL +      +      KW K  +E
Sbjct: 18880 GVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPT-CKWKKGEDE 18938

Query: 292   LNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVES 347
             +   +   ++ + K    S L I   +  DSG Y     +  G D+    + ++++
Sbjct: 18939 VVTSS---HLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDA 18991


>gi|221316757 neurotrimin isoform 3 [Homo sapiens]
          Length = 355

 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 37/122 (30%), Positives = 55/122 (45%), Gaps = 12/122 (9%)

Query: 251 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310
           PP + E K      G K  L+CE S+   S  F+W+K+   L    K   +K++ +P  S
Sbjct: 222 PPYISEAKGTGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK--GVKVENRPFLS 278

Query: 311 ELRINKASLADSGEYMCKVISKLGNDSASANITIVES---------NATSTSTTGTSHLV 361
           +L     S  D G Y C   +KLG+ +AS  +  V++          A S  + GTS   
Sbjct: 279 KLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFEVKTTALTPWKGPGAVSEVSNGTSRRA 338

Query: 362 KC 363
            C
Sbjct: 339 GC 340


>gi|66730481 neuregulin 3 [Homo sapiens]
          Length = 696

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 24/82 (29%), Positives = 44/82 (53%), Gaps = 7/82 (8%)

Query: 331 SKLGNDSASANITIVESNA------TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLS 384
           S   + S+SA  T  E++       T+ ST  + H   C +K+  +C+N GECF+++ L+
Sbjct: 252 SSSSSSSSSATTTTPETSTSPKFHTTTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLT 311

Query: 385 NPSRYLCKCPNEFTGDRCQNYV 406
              ++ C+C   + G RC  ++
Sbjct: 312 GSHKH-CRCKEGYQGVRCDQFL 332


>gi|45594240 limbic system-associated membrane protein [Homo
           sapiens]
          Length = 338

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 27/89 (30%), Positives = 46/89 (51%), Gaps = 4/89 (4%)

Query: 251 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310
           PP + E KS E+  G +  L+CE S+   +  F+W+++   +N  N    ++I+   G+S
Sbjct: 218 PPTITESKSNEATTGRQASLKCEASA-VPAPDFEWYRDDTRINSAN---GLEIKSTEGQS 273

Query: 311 ELRINKASLADSGEYMCKVISKLGNDSAS 339
            L +   +    G Y C   +KLG  +AS
Sbjct: 274 SLTVTNVTEEHYGNYTCVAANKLGVTNAS 302


>gi|221316762 neurotrimin isoform 4 [Homo sapiens]
          Length = 316

 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 30/89 (33%), Positives = 44/89 (49%), Gaps = 3/89 (3%)

Query: 251 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310
           PP + E K      G K  L+CE S+   S  F+W+K+   L    K   +K++ +P  S
Sbjct: 222 PPYISEAKGTGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK--GVKVENRPFLS 278

Query: 311 ELRINKASLADSGEYMCKVISKLGNDSAS 339
           +L     S  D G Y C   +KLG+ +AS
Sbjct: 279 KLIFFNVSEHDYGNYTCVASNKLGHTNAS 307


>gi|110349717 titin isoform novex-2 [Homo sapiens]
          Length = 27118

 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 30/96 (31%), Positives = 48/96 (50%), Gaps = 4/96 (4%)

Query: 249  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 308
            A P   ++++  E A G      CE  S   ++RF+WFK G E+   +K     I+    
Sbjct: 4527 AAPVIKRKIEPLEVALGHLAKFTCEIQSA-PNVRFQWFKAGREIYESDK---CSIRSSKY 4582

Query: 309  KSELRINKASLADSGEYMCKVISKLGNDSASANITI 344
             S L I +  + D GEY CK  ++ G+ S +A +T+
Sbjct: 4583 ISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 4618



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 28/95 (29%), Positives = 48/95 (50%), Gaps = 4/95 (4%)

Query: 251   PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310
             P  + + +SQ    G  ++  CE S E S    +WFKN   ++  +   N+ I +     
Sbjct: 26829 PAFISQPRSQNINEGQNVLFTCEISGEPSP-EIEWFKNNLPISISS---NVSISRSRNVY 26884

Query: 311   ELRINKASLADSGEYMCKVISKLGNDSASANITIV 345
              L I  AS++DSG+Y  K  +  G  SA+A++ ++
Sbjct: 26885 SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVL 26919



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 27/78 (34%), Positives = 40/78 (51%), Gaps = 10/78 (12%)

Query: 267  KLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM 326
            ++ L+CE S +   +  KWFK+G E+    K     I+    +  L+I KA L D GEY+
Sbjct: 5374 EITLKCEVSKD---VPVKWFKDGEEIVPSPK---YSIKADGLRRILKIKKADLKDKGEYV 5427

Query: 327  CKVISKLGNDSASANITI 344
            C      G D   AN+T+
Sbjct: 5428 C----DCGTDKTKANVTV 5441



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 30/109 (27%), Positives = 47/109 (43%), Gaps = 8/109 (7%)

Query: 245  CKRCALPPRLKEMKS-QESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 303
            C    +PP ++ ++   +     K + R E      + + KWFK+G E+ +  K     I
Sbjct: 6060 CNLNVVPPHVEFLRPLTDLQVREKEMARFECELSRENAKVKWFKDGAEIKKGKK---YDI 6116

Query: 304  QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATST 352
              K     L INK  L D  EY C+V +       S  +T++E  A  T
Sbjct: 6117 ISKGAVRILVINKCLLDDEAEYSCEVRTA----RTSGMLTVLEEEAVFT 6161



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 28/120 (23%), Positives = 49/120 (40%), Gaps = 6/120 (5%)

Query: 251  PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310
            P  +  +K+     G  + L C  S  Y S    W++   ++       + +I  + G +
Sbjct: 897  PTLVSGLKNVTVIEGESVTLECHISG-YPSPTVTWYREDYQIESSI---DFQITFQSGIA 952

Query: 311  ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTF 370
             L I +A   DSG + C  +++ G  S S  + +  S      TT  +   K   +EK F
Sbjct: 953  RLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE--KFTTEEKRF 1010



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 25/79 (31%), Positives = 39/79 (49%), Gaps = 6/79 (7%)

Query: 285   WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT- 343
             W K+G  + +  K    K+ +  G   L I+K   +DSG Y C V +  G+ S+S  +T 
Sbjct: 26580 WTKDGKAITQGGK---YKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 26636

Query: 344   --IVESNATSTSTTGTSHL 360
               I ++ A   ST  TS +
Sbjct: 26637 KAIKDTEAQKVSTQKTSEI 26655



 Score = 37.7 bits (86), Expect = 0.020
 Identities = 18/70 (25%), Positives = 31/70 (44%)

Query: 285   WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 344
             W+K+G ++   +  +    +   G  +L IN  +  D  EY     +K G DS  A +T+
Sbjct: 25418 WYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 25477

Query: 345   VESNATSTST 354
                   + ST
Sbjct: 25478 TLHPPPTDST 25487



 Score = 37.7 bits (86), Expect = 0.020
 Identities = 46/197 (23%), Positives = 80/197 (40%), Gaps = 21/197 (10%)

Query: 150   SAGEPGEEAPYLVKVHQVWAVKAGGLKKDSLLTVRLGTWGHPAFPSCGRLKEDSRYIFFM 209
             S+ +  +E  Y V V        G  + +  LT++       A  S  R+K     +   
Sbjct: 26316 SSVQASDEGNYSVVVEN----SEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRV--K 26369

Query: 210   EPDANSTSRAPAAFRASFP----PLETGRNLKKEVSRVLCKRCALPPRLKEMKSQESAAG 265
              P+A  + +   +   S P    P ET     ++V  +     + PP++ +    E+   
Sbjct: 26370 SPEAVKSPKRVKSPEPSHPKAVSPTETKPTPTEKVQHL---PVSAPPKITQFLKAEA--- 26423

Query: 266   SKLVLRCETSSEYSSLRFK---WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADS 322
             SK + +     E S LR K   W+K+G +L      Q        G  EL+IN  + +D 
Sbjct: 26424 SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH--YSADGTYELKINNLTESDQ 26481

Query: 323   GEYMCKVISKLGNDSAS 339
             GEY+C++  + G    +
Sbjct: 26482 GEYVCEISGEGGTSKTN 26498



 Score = 35.4 bits (80), Expect = 0.098
 Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 2/43 (4%)

Query: 255  KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNK 297
            K ++ Q    G+  VL CE S E  + + KWFKNG E+ +  K
Sbjct: 5984 KPLEDQTVEEGATAVLECEVSRE--NAKVKWFKNGTEILKSKK 6024



 Score = 34.3 bits (77), Expect = 0.22
 Identities = 26/104 (25%), Positives = 39/104 (37%), Gaps = 3/104 (2%)

Query: 251  PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310
            P  LKE+K    A G   +       E +     WFK   +L          I    G  
Sbjct: 3767 PHFLKELKPIRCAQGLPAIFEYTVVGEPAPT-VTWFKENKQLC--TSVYYTIIHNPNGSG 3823

Query: 311  ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST 354
               +N     DSG Y+CK  + LG  + +A + ++  +   T T
Sbjct: 3824 TFIVNDPQREDSGLYICKAENMLGESTCAAELLVLLEDTDMTDT 3867



 Score = 33.9 bits (76), Expect = 0.29
 Identities = 29/103 (28%), Positives = 43/103 (41%), Gaps = 7/103 (6%)

Query: 255  KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 314
            K +  Q  A   + V  CE ++  S  + +W ++G  L   N   NI+ +    K  L I
Sbjct: 2578 KPLTDQTVAESQEAVFECEVANPDS--KGEWLRDGKHLPLTN---NIRSESDGHKRRLII 2632

Query: 315  NKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGT 357
                L D GEY  KV +     SA   +  V+   T  + T T
Sbjct: 2633 AATKLDDIGEYTYKVAT--SKTSAKLKVEAVKIKKTLKNLTVT 2673



 Score = 33.5 bits (75), Expect = 0.37
 Identities = 18/73 (24%), Positives = 33/73 (45%), Gaps = 3/73 (4%)

Query: 272   CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 331
             C+  +   S +  W+    +L    K    +I  + G + L +   +  D G Y CKV++
Sbjct: 25284 CKIENYDQSTQVTWYFGVRQLENSEK---YEITYEDGVAILYVKDITKLDDGTYRCKVVN 25340

Query: 332   KLGNDSASANITI 344
               G DS+ A + +
Sbjct: 25341 DYGEDSSYAELFV 25353



 Score = 33.5 bits (75), Expect = 0.37
 Identities = 36/147 (24%), Positives = 57/147 (38%), Gaps = 15/147 (10%)

Query: 210   EPDANSTSRAPAAFRASFPPLETGRNLKKEVS-RVLCKRCALPPRLKEMKSQESAAGSKL 268
             E  A++  ++ A    S     T R +K  ++ R+L K     PR   +   ESA  S  
Sbjct: 26224 EHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTK-----PRSMTVYEGESARFS-- 26276

Query: 269   VLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCK 328
                C+T  E       W + G  L+   + Q   +     KS   I+    +D G Y   
Sbjct: 26277 ---CDTDGEPVPT-VTWLRKGQVLSTSARHQ---VTTTKYKSTFEISSVQASDEGNYSVV 26329

Query: 329   VISKLGNDSASANITIVESNATSTSTT 355
             V +  G   A   +TI ++  T  + T
Sbjct: 26330 VENSEGKQEAEFTLTIQKARVTEKAVT 26356



 Score = 33.1 bits (74), Expect = 0.49
 Identities = 26/101 (25%), Positives = 41/101 (40%), Gaps = 25/101 (24%)

Query: 254  LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 313
            LK++ ++E     K  +  E +  Y  + +KW KNG E+   +K Q   ++ K     L 
Sbjct: 2929 LKDINAEE-----KDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQ---MRTKKLTHSLN 2980

Query: 314  INKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST 354
            I      D+ +Y                 T V   ATST+T
Sbjct: 2981 IRNVHFGDAADY-----------------TFVAGKATSTAT 3004



 Score = 33.1 bits (74), Expect = 0.49
 Identities = 26/96 (27%), Positives = 44/96 (45%), Gaps = 11/96 (11%)

Query: 254  LKEMK----SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 309
            +KE+K    ++    GS  +  C  S   S+    W K+G+ +    K + I   K    
Sbjct: 4813 VKEIKDIILTESEFVGSSAIFECLVSP--STAITTWMKDGSNIRESPKHRFIADGKD--- 4867

Query: 310  SELRINKASLADSGEYMCKVISKLGNDSASANITIV 345
             +L I    L+D+GEY C  + +LGN   ++   +V
Sbjct: 4868 RKLHIIDVQLSDAGEYTC--VLRLGNKEKTSTAKLV 4901



 Score = 32.7 bits (73), Expect = 0.64
 Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 5/76 (6%)

Query: 254  LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 313
            ++ ++ Q        V  C+ S E +++  KW++NG E+    K    K +K      L 
Sbjct: 6521 VEHLEDQTVTEFDDAVFSCQLSREKANV--KWYRNGREIKEGKK---YKFEKDGSIHRLI 6575

Query: 314  INKASLADSGEYMCKV 329
            I    L D  EY C V
Sbjct: 6576 IKDCRLDDECEYACGV 6591



 Score = 32.7 bits (73), Expect = 0.64
 Identities = 16/61 (26%), Positives = 34/61 (55%), Gaps = 3/61 (4%)

Query: 285  WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 344
            W K+G E+   ++   + ++     + L + K+  AD+G Y   + +KLG+ +AS N+ +
Sbjct: 8115 WHKDGKEVKASDR---LTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKV 8171

Query: 345  V 345
            +
Sbjct: 8172 I 8172



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 23/83 (27%), Positives = 38/83 (45%), Gaps = 2/83 (2%)

Query: 260  QESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASL 319
            Q+   G  +V  C+         + W K+G  L    +   +   K+ G+ +L I+    
Sbjct: 1045 QKLVEGGSVVFGCQVGGNPKPHVY-WKKSGVPLTTGYR-YKVSYNKQTGECKLVISMTFA 1102

Query: 320  ADSGEYMCKVISKLGNDSASANI 342
             D+GEY   V +K G  SASA++
Sbjct: 1103 DDAGEYTIVVRNKHGETSASASL 1125



 Score = 31.6 bits (70), Expect = 1.4
 Identities = 28/100 (28%), Positives = 44/100 (44%), Gaps = 10/100 (10%)

Query: 247  RCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 306
            R  +P +   +K Q+     ++V  CE ++E    + KWF+N   +   +K     I +K
Sbjct: 6336 RIVVPLKDTRVKEQQ-----EVVFNCEVNTE--GAKAKWFRNEEAIFDSSK---YIILQK 6385

Query: 307  PGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346
                 LRI  A L D   Y   + +  G +  SA   IVE
Sbjct: 6386 DLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVE 6425



 Score = 30.8 bits (68), Expect = 2.4
 Identities = 33/143 (23%), Positives = 60/143 (41%), Gaps = 8/143 (5%)

Query: 208   FMEPDANSTSRAPAAF----RASFPPLETGRNLKKEVSRVLCKRC-ALPPRLKEMKSQES 262
             F    A S S    +F     +SF  +     L+   S++L      +PP+++ + S  S
Sbjct: 26975 FASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDIS 27034

Query: 263   A-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLAD 321
                G  L + C  + E +     W   G +++ + + +   I+     + L I      D
Sbjct: 27035 IDEGKVLTVACAFTGEPTP-EVTWSCGGRKIHSQEQGR-FHIENTDDLTTLIIMDVQKQD 27092

Query: 322   SGEYMCKVISKLGNDSASANITI 344
              G Y   + ++ G+DSA+ NI I
Sbjct: 27093 GGLYTLSLGNEFGSDSATVNIHI 27115



 Score = 29.6 bits (65), Expect = 5.4
 Identities = 14/62 (22%), Positives = 31/62 (50%), Gaps = 1/62 (1%)

Query: 285   WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 344
             W K+ +  +    P+ +KI  +   S+  + KA  +D G+Y+    +  G+  A A + +
Sbjct: 11930 WTKDKDATDLTRSPR-VKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNV 11988

Query: 345   VE 346
             ++
Sbjct: 11989 LD 11990



 Score = 29.6 bits (65), Expect = 5.4
 Identities = 21/84 (25%), Positives = 36/84 (42%), Gaps = 5/84 (5%)

Query: 264   AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNI-KIQKKPGKSELRINKASLADS 322
             AG  +VL   +       +  W K G ++    +P +I +I   P  S L I  A+  D+
Sbjct: 14087 AGDTIVLNAISILGKPLPKSSWSKAGKDI----RPSDITQITSTPTSSMLTIKYATRKDA 14142

Query: 323   GEYMCKVISKLGNDSASANITIVE 346
             GEY     +  G       +T+++
Sbjct: 14143 GEYTITATNPFGTKVEHVKVTVLD 14166



 Score = 29.3 bits (64), Expect = 7.0
 Identities = 19/71 (26%), Positives = 33/71 (46%), Gaps = 5/71 (7%)

Query: 255  KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 314
            K +K  +     + +  CE S     +  +W K+  EL   ++   IKIQK+     L I
Sbjct: 3016 KHIKDIKVLEKKRAMFECEVSEP--DITVQWMKDDQELQITDR---IKIQKEKYVHRLLI 3070

Query: 315  NKASLADSGEY 325
                ++D+G+Y
Sbjct: 3071 PSTRMSDAGKY 3081



 Score = 28.9 bits (63), Expect = 9.2
 Identities = 16/66 (24%), Positives = 29/66 (43%), Gaps = 3/66 (4%)

Query: 284  KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 343
            +W  +G  L   N+   +++  + G   L    A   DSG   C+  +K G D  SA + 
Sbjct: 1691 EWLHDGKPLEAANR---LRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLI 1747

Query: 344  IVESNA 349
            + +  +
Sbjct: 1748 VKDEKS 1753



 Score = 28.9 bits (63), Expect = 9.2
 Identities = 14/39 (35%), Positives = 24/39 (61%), Gaps = 1/39 (2%)

Query: 312  LRINKASLAD-SGEYMCKVISKLGNDSASANITIVESNA 349
            L I+K +  D  GEY+C+ ++  G  + SA +T+V+  A
Sbjct: 4490 LVIDKVNTEDHQGEYVCEALNDSGKTATSAKLTVVKRAA 4528



 Score = 28.9 bits (63), Expect = 9.2
 Identities = 26/116 (22%), Positives = 47/116 (40%), Gaps = 5/116 (4%)

Query: 233   GRNLKKEVSRVL-CKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNE 291
             G +L +E   V   K   LPP++   +     AG KL +      +      KW K  +E
Sbjct: 12575 GVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPT-CKWKKGEDE 12633

Query: 292   LNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVES 347
             +   +   ++ + K    S L I   +  DSG Y     +  G D+    + ++++
Sbjct: 12634 VVTSS---HLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDA 12686


>gi|110349713 titin isoform novex-1 [Homo sapiens]
          Length = 27051

 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 30/96 (31%), Positives = 48/96 (50%), Gaps = 4/96 (4%)

Query: 249  ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 308
            A P   ++++  E A G      CE  S   ++RF+WFK G E+   +K     I+    
Sbjct: 4460 AAPVIKRKIEPLEVALGHLAKFTCEIQSA-PNVRFQWFKAGREIYESDK---CSIRSSKY 4515

Query: 309  KSELRINKASLADSGEYMCKVISKLGNDSASANITI 344
             S L I +  + D GEY CK  ++ G+ S +A +T+
Sbjct: 4516 ISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 4551



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 28/95 (29%), Positives = 48/95 (50%), Gaps = 4/95 (4%)

Query: 251   PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310
             P  + + +SQ    G  ++  CE S E S    +WFKN   ++  +   N+ I +     
Sbjct: 26762 PAFISQPRSQNINEGQNVLFTCEISGEPSP-EIEWFKNNLPISISS---NVSISRSRNVY 26817

Query: 311   ELRINKASLADSGEYMCKVISKLGNDSASANITIV 345
              L I  AS++DSG+Y  K  +  G  SA+A++ ++
Sbjct: 26818 SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVL 26852



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 27/78 (34%), Positives = 40/78 (51%), Gaps = 10/78 (12%)

Query: 267  KLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM 326
            ++ L+CE S +   +  KWFK+G E+    K     I+    +  L+I KA L D GEY+
Sbjct: 5307 EITLKCEVSKD---VPVKWFKDGEEIVPSPK---YSIKADGLRRILKIKKADLKDKGEYV 5360

Query: 327  CKVISKLGNDSASANITI 344
            C      G D   AN+T+
Sbjct: 5361 C----DCGTDKTKANVTV 5374



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 30/109 (27%), Positives = 47/109 (43%), Gaps = 8/109 (7%)

Query: 245  CKRCALPPRLKEMKS-QESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 303
            C    +PP ++ ++   +     K + R E      + + KWFK+G E+ +  K     I
Sbjct: 5993 CNLNVVPPHVEFLRPLTDLQVREKEMARFECELSRENAKVKWFKDGAEIKKGKK---YDI 6049

Query: 304  QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATST 352
              K     L INK  L D  EY C+V +       S  +T++E  A  T
Sbjct: 6050 ISKGAVRILVINKCLLDDEAEYSCEVRTA----RTSGMLTVLEEEAVFT 6094



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 28/120 (23%), Positives = 49/120 (40%), Gaps = 6/120 (5%)

Query: 251  PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310
            P  +  +K+     G  + L C  S  Y S    W++   ++       + +I  + G +
Sbjct: 897  PTLVSGLKNVTVIEGESVTLECHISG-YPSPTVTWYREDYQIESSI---DFQITFQSGIA 952

Query: 311  ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTF 370
             L I +A   DSG + C  +++ G  S S  + +  S      TT  +   K   +EK F
Sbjct: 953  RLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE--KFTTEEKRF 1010



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 25/79 (31%), Positives = 39/79 (49%), Gaps = 6/79 (7%)

Query: 285   WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT- 343
             W K+G  + +  K    K+ +  G   L I+K   +DSG Y C V +  G+ S+S  +T 
Sbjct: 26513 WTKDGKAITQGGK---YKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 26569

Query: 344   --IVESNATSTSTTGTSHL 360
               I ++ A   ST  TS +
Sbjct: 26570 KAIKDTEAQKVSTQKTSEI 26588



 Score = 37.7 bits (86), Expect = 0.020
 Identities = 18/70 (25%), Positives = 31/70 (44%)

Query: 285   WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 344
             W+K+G ++   +  +    +   G  +L IN  +  D  EY     +K G DS  A +T+
Sbjct: 25351 WYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 25410

Query: 345   VESNATSTST 354
                   + ST
Sbjct: 25411 TLHPPPTDST 25420



 Score = 37.7 bits (86), Expect = 0.020
 Identities = 46/197 (23%), Positives = 80/197 (40%), Gaps = 21/197 (10%)

Query: 150   SAGEPGEEAPYLVKVHQVWAVKAGGLKKDSLLTVRLGTWGHPAFPSCGRLKEDSRYIFFM 209
             S+ +  +E  Y V V        G  + +  LT++       A  S  R+K     +   
Sbjct: 26249 SSVQASDEGNYSVVVEN----SEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRV--K 26302

Query: 210   EPDANSTSRAPAAFRASFP----PLETGRNLKKEVSRVLCKRCALPPRLKEMKSQESAAG 265
              P+A  + +   +   S P    P ET     ++V  +     + PP++ +    E+   
Sbjct: 26303 SPEAVKSPKRVKSPEPSHPKAVSPTETKPTPTEKVQHL---PVSAPPKITQFLKAEA--- 26356

Query: 266   SKLVLRCETSSEYSSLRFK---WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADS 322
             SK + +     E S LR K   W+K+G +L      Q        G  EL+IN  + +D 
Sbjct: 26357 SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH--YSADGTYELKINNLTESDQ 26414

Query: 323   GEYMCKVISKLGNDSAS 339
             GEY+C++  + G    +
Sbjct: 26415 GEYVCEISGEGGTSKTN 26431



 Score = 35.4 bits (80), Expect = 0.098
 Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 2/43 (4%)

Query: 255  KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNK 297
            K ++ Q    G+  VL CE S E  + + KWFKNG E+ +  K
Sbjct: 5917 KPLEDQTVEEGATAVLECEVSRE--NAKVKWFKNGTEILKSKK 5957



 Score = 34.3 bits (77), Expect = 0.22
 Identities = 26/104 (25%), Positives = 39/104 (37%), Gaps = 3/104 (2%)

Query: 251  PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310
            P  LKE+K    A G   +       E +     WFK   +L          I    G  
Sbjct: 3700 PHFLKELKPIRCAQGLPAIFEYTVVGEPAPT-VTWFKENKQLC--TSVYYTIIHNPNGSG 3756

Query: 311  ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST 354
               +N     DSG Y+CK  + LG  + +A + ++  +   T T
Sbjct: 3757 TFIVNDPQREDSGLYICKAENMLGESTCAAELLVLLEDTDMTDT 3800



 Score = 33.9 bits (76), Expect = 0.29
 Identities = 29/103 (28%), Positives = 43/103 (41%), Gaps = 7/103 (6%)

Query: 255  KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 314
            K +  Q  A   + V  CE ++  S  + +W ++G  L   N   NI+ +    K  L I
Sbjct: 2578 KPLTDQTVAESQEAVFECEVANPDS--KGEWLRDGKHLPLTN---NIRSESDGHKRRLII 2632

Query: 315  NKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGT 357
                L D GEY  KV +     SA   +  V+   T  + T T
Sbjct: 2633 AATKLDDIGEYTYKVAT--SKTSAKLKVEAVKIKKTLKNLTVT 2673



 Score = 33.5 bits (75), Expect = 0.37
 Identities = 18/73 (24%), Positives = 33/73 (45%), Gaps = 3/73 (4%)

Query: 272   CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 331
             C+  +   S +  W+    +L    K    +I  + G + L +   +  D G Y CKV++
Sbjct: 25217 CKIENYDQSTQVTWYFGVRQLENSEK---YEITYEDGVAILYVKDITKLDDGTYRCKVVN 25273

Query: 332   KLGNDSASANITI 344
               G DS+ A + +
Sbjct: 25274 DYGEDSSYAELFV 25286



 Score = 33.5 bits (75), Expect = 0.37
 Identities = 36/147 (24%), Positives = 57/147 (38%), Gaps = 15/147 (10%)

Query: 210   EPDANSTSRAPAAFRASFPPLETGRNLKKEVS-RVLCKRCALPPRLKEMKSQESAAGSKL 268
             E  A++  ++ A    S     T R +K  ++ R+L K     PR   +   ESA  S  
Sbjct: 26157 EHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTK-----PRSMTVYEGESARFS-- 26209

Query: 269   VLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCK 328
                C+T  E       W + G  L+   + Q   +     KS   I+    +D G Y   
Sbjct: 26210 ---CDTDGEPVPT-VTWLRKGQVLSTSARHQ---VTTTKYKSTFEISSVQASDEGNYSVV 26262

Query: 329   VISKLGNDSASANITIVESNATSTSTT 355
             V +  G   A   +TI ++  T  + T
Sbjct: 26263 VENSEGKQEAEFTLTIQKARVTEKAVT 26289



 Score = 33.1 bits (74), Expect = 0.49
 Identities = 26/101 (25%), Positives = 41/101 (40%), Gaps = 25/101 (24%)

Query: 254  LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 313
            LK++ ++E     K  +  E +  Y  + +KW KNG E+   +K Q   ++ K     L 
Sbjct: 2929 LKDINAEE-----KDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQ---MRTKKLTHSLN 2980

Query: 314  INKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST 354
            I      D+ +Y                 T V   ATST+T
Sbjct: 2981 IRNVHFGDAADY-----------------TFVAGKATSTAT 3004



 Score = 33.1 bits (74), Expect = 0.49
 Identities = 26/96 (27%), Positives = 44/96 (45%), Gaps = 11/96 (11%)

Query: 254  LKEMK----SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 309
            +KE+K    ++    GS  +  C  S   S+    W K+G+ +    K + I   K    
Sbjct: 4746 VKEIKDIILTESEFVGSSAIFECLVSP--STAITTWMKDGSNIRESPKHRFIADGKD--- 4800

Query: 310  SELRINKASLADSGEYMCKVISKLGNDSASANITIV 345
             +L I    L+D+GEY C  + +LGN   ++   +V
Sbjct: 4801 RKLHIIDVQLSDAGEYTC--VLRLGNKEKTSTAKLV 4834



 Score = 32.7 bits (73), Expect = 0.64
 Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 5/76 (6%)

Query: 254  LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 313
            ++ ++ Q        V  C+ S E +++  KW++NG E+    K    K +K      L 
Sbjct: 6454 VEHLEDQTVTEFDDAVFSCQLSREKANV--KWYRNGREIKEGKK---YKFEKDGSIHRLI 6508

Query: 314  INKASLADSGEYMCKV 329
            I    L D  EY C V
Sbjct: 6509 IKDCRLDDECEYACGV 6524



 Score = 32.7 bits (73), Expect = 0.64
 Identities = 16/61 (26%), Positives = 34/61 (55%), Gaps = 3/61 (4%)

Query: 285  WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 344
            W K+G E+   ++   + ++     + L + K+  AD+G Y   + +KLG+ +AS N+ +
Sbjct: 8048 WHKDGKEVKASDR---LTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKV 8104

Query: 345  V 345
            +
Sbjct: 8105 I 8105



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 23/83 (27%), Positives = 38/83 (45%), Gaps = 2/83 (2%)

Query: 260  QESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASL 319
            Q+   G  +V  C+         + W K+G  L    +   +   K+ G+ +L I+    
Sbjct: 1045 QKLVEGGSVVFGCQVGGNPKPHVY-WKKSGVPLTTGYR-YKVSYNKQTGECKLVISMTFA 1102

Query: 320  ADSGEYMCKVISKLGNDSASANI 342
             D+GEY   V +K G  SASA++
Sbjct: 1103 DDAGEYTIVVRNKHGETSASASL 1125



 Score = 31.6 bits (70), Expect = 1.4
 Identities = 28/100 (28%), Positives = 44/100 (44%), Gaps = 10/100 (10%)

Query: 247  RCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 306
            R  +P +   +K Q+     ++V  CE ++E    + KWF+N   +   +K     I +K
Sbjct: 6269 RIVVPLKDTRVKEQQ-----EVVFNCEVNTE--GAKAKWFRNEEAIFDSSK---YIILQK 6318

Query: 307  PGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346
                 LRI  A L D   Y   + +  G +  SA   IVE
Sbjct: 6319 DLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVE 6358



 Score = 30.8 bits (68), Expect = 2.4
 Identities = 33/143 (23%), Positives = 60/143 (41%), Gaps = 8/143 (5%)

Query: 208   FMEPDANSTSRAPAAF----RASFPPLETGRNLKKEVSRVLCKRC-ALPPRLKEMKSQES 262
             F    A S S    +F     +SF  +     L+   S++L      +PP+++ + S  S
Sbjct: 26908 FASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDIS 26967

Query: 263   A-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLAD 321
                G  L + C  + E +     W   G +++ + + +   I+     + L I      D
Sbjct: 26968 IDEGKVLTVACAFTGEPTP-EVTWSCGGRKIHSQEQGR-FHIENTDDLTTLIIMDVQKQD 27025

Query: 322   SGEYMCKVISKLGNDSASANITI 344
              G Y   + ++ G+DSA+ NI I
Sbjct: 27026 GGLYTLSLGNEFGSDSATVNIHI 27048



 Score = 29.6 bits (65), Expect = 5.4
 Identities = 14/62 (22%), Positives = 31/62 (50%), Gaps = 1/62 (1%)

Query: 285   WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 344
             W K+ +  +    P+ +KI  +   S+  + KA  +D G+Y+    +  G+  A A + +
Sbjct: 11863 WTKDKDATDLTRSPR-VKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNV 11921

Query: 345   VE 346
             ++
Sbjct: 11922 LD 11923



 Score = 29.6 bits (65), Expect = 5.4
 Identities = 21/84 (25%), Positives = 36/84 (42%), Gaps = 5/84 (5%)

Query: 264   AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNI-KIQKKPGKSELRINKASLADS 322
             AG  +VL   +       +  W K G ++    +P +I +I   P  S L I  A+  D+
Sbjct: 14020 AGDTIVLNAISILGKPLPKSSWSKAGKDI----RPSDITQITSTPTSSMLTIKYATRKDA 14075

Query: 323   GEYMCKVISKLGNDSASANITIVE 346
             GEY     +  G       +T+++
Sbjct: 14076 GEYTITATNPFGTKVEHVKVTVLD 14099



 Score = 29.3 bits (64), Expect = 7.0
 Identities = 19/71 (26%), Positives = 33/71 (46%), Gaps = 5/71 (7%)

Query: 255  KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 314
            K +K  +     + +  CE S     +  +W K+  EL   ++   IKIQK+     L I
Sbjct: 3016 KHIKDIKVLEKKRAMFECEVSEP--DITVQWMKDDQELQITDR---IKIQKEKYVHRLLI 3070

Query: 315  NKASLADSGEY 325
                ++D+G+Y
Sbjct: 3071 PSTRMSDAGKY 3081



 Score = 28.9 bits (63), Expect = 9.2
 Identities = 16/66 (24%), Positives = 29/66 (43%), Gaps = 3/66 (4%)

Query: 284  KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 343
            +W  +G  L   N+   +++  + G   L    A   DSG   C+  +K G D  SA + 
Sbjct: 1691 EWLHDGKPLEAANR---LRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLI 1747

Query: 344  IVESNA 349
            + +  +
Sbjct: 1748 VKDEKS 1753



 Score = 28.9 bits (63), Expect = 9.2
 Identities = 14/39 (35%), Positives = 24/39 (61%), Gaps = 1/39 (2%)

Query: 312  LRINKASLAD-SGEYMCKVISKLGNDSASANITIVESNA 349
            L I+K +  D  GEY+C+ ++  G  + SA +T+V+  A
Sbjct: 4423 LVIDKVNTEDHQGEYVCEALNDSGKTATSAKLTVVKRAA 4461



 Score = 28.9 bits (63), Expect = 9.2
 Identities = 26/116 (22%), Positives = 47/116 (40%), Gaps = 5/116 (4%)

Query: 233   GRNLKKEVSRVL-CKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNE 291
             G +L +E   V   K   LPP++   +     AG KL +      +      KW K  +E
Sbjct: 12508 GVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPT-CKWKKGEDE 12566

Query: 292   LNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVES 347
             +   +   ++ + K    S L I   +  DSG Y     +  G D+    + ++++
Sbjct: 12567 VVTSS---HLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDA 12619


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.130    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,950,587
Number of Sequences: 37866
Number of extensions: 1006718
Number of successful extensions: 7768
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 153
Number of HSP's successfully gapped in prelim test: 610
Number of HSP's that attempted gapping in prelim test: 6018
Number of HSP's gapped (non-prelim): 2226
length of query: 422
length of database: 18,247,518
effective HSP length: 105
effective length of query: 317
effective length of database: 14,271,588
effective search space: 4524093396
effective search space used: 4524093396
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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