BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens] (422 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens] 856 0.0 gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens] 355 3e-98 gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens] 337 1e-92 gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens] 333 1e-91 gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens] 323 2e-88 gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens] 316 3e-86 gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens] 316 3e-86 gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens] 316 3e-86 gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens] 316 3e-86 gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens] 315 5e-86 gi|236464356 neuregulin 1 isoform HRG-gamma3 [Homo sapiens] 291 8e-79 gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens] 286 3e-77 gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens] 286 3e-77 gi|236462984 neuregulin 1 isoform HRG-gamma2 [Homo sapiens] 280 1e-75 gi|116006965 neuregulin 1 isoform HRG-gamma [Homo sapiens] 273 3e-73 gi|7669528 neuregulin 2 isoform 2 [Homo sapiens] 196 3e-50 gi|7669532 neuregulin 2 isoform 4 [Homo sapiens] 196 3e-50 gi|7669530 neuregulin 2 isoform 3 [Homo sapiens] 188 9e-48 gi|4758832 neuregulin 2 isoform 1 [Homo sapiens] 188 9e-48 gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens] 160 2e-39 gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens] 112 6e-25 gi|115298665 neurotrimin isoform 2 [Homo sapiens] 56 7e-08 gi|7705413 neurotrimin isoform 1 [Homo sapiens] 56 7e-08 gi|110349719 titin isoform N2-A [Homo sapiens] 54 2e-07 gi|221316757 neurotrimin isoform 3 [Homo sapiens] 53 6e-07 gi|66730481 neuregulin 3 [Homo sapiens] 51 2e-06 gi|45594240 limbic system-associated membrane protein [Homo sapi... 51 2e-06 gi|221316762 neurotrimin isoform 4 [Homo sapiens] 50 3e-06 gi|110349717 titin isoform novex-2 [Homo sapiens] 50 5e-06 gi|110349713 titin isoform novex-1 [Homo sapiens] 50 5e-06 >gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens] Length = 422 Score = 856 bits (2212), Expect = 0.0 Identities = 422/422 (100%), Positives = 422/422 (100%) Query: 1 MRWRRAPRRSGRPGPRAQRPGSAARSSPPLPLLPLLLLLGTAALAPGAAAGNEAAPAGAS 60 MRWRRAPRRSGRPGPRAQRPGSAARSSPPLPLLPLLLLLGTAALAPGAAAGNEAAPAGAS Sbjct: 1 MRWRRAPRRSGRPGPRAQRPGSAARSSPPLPLLPLLLLLGTAALAPGAAAGNEAAPAGAS 60 Query: 61 VCYSSPPSVGSVQELAQRAAVVIEGKVHPQRRQQGALDRKAAAAAGEAGAWGGDREPPAA 120 VCYSSPPSVGSVQELAQRAAVVIEGKVHPQRRQQGALDRKAAAAAGEAGAWGGDREPPAA Sbjct: 61 VCYSSPPSVGSVQELAQRAAVVIEGKVHPQRRQQGALDRKAAAAAGEAGAWGGDREPPAA 120 Query: 121 GPRALGPPAEEPLLAANGTVPSWPTAPVPSAGEPGEEAPYLVKVHQVWAVKAGGLKKDSL 180 GPRALGPPAEEPLLAANGTVPSWPTAPVPSAGEPGEEAPYLVKVHQVWAVKAGGLKKDSL Sbjct: 121 GPRALGPPAEEPLLAANGTVPSWPTAPVPSAGEPGEEAPYLVKVHQVWAVKAGGLKKDSL 180 Query: 181 LTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFRASFPPLETGRNLKKEV 240 LTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFRASFPPLETGRNLKKEV Sbjct: 181 LTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFRASFPPLETGRNLKKEV 240 Query: 241 SRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQN 300 SRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQN Sbjct: 241 SRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQN 300 Query: 301 IKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHL 360 IKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHL Sbjct: 301 IKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHL 360 Query: 361 VKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPFLSL 420 VKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPFLSL Sbjct: 361 VKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPFLSL 420 Query: 421 PE 422 PE Sbjct: 421 PE 422 >gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens] Length = 207 Score = 355 bits (912), Expect = 3e-98 Identities = 177/186 (95%), Positives = 178/186 (95%) Query: 237 KKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 296 KK S + ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN Sbjct: 22 KKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81 Query: 297 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTG 356 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTG Sbjct: 82 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTG 141 Query: 357 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTP 416 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTP Sbjct: 142 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTP 201 Query: 417 FLSLPE 422 FLSLPE Sbjct: 202 FLSLPE 207 >gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens] Length = 241 Score = 337 bits (864), Expect = 1e-92 Identities = 176/220 (80%), Positives = 178/220 (80%), Gaps = 34/220 (15%) Query: 237 KKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 296 KK S + ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN Sbjct: 22 KKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81 Query: 297 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------- 348 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN Sbjct: 82 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 141 Query: 349 --------------------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 382 +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD Sbjct: 142 STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 201 Query: 383 LSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPFLSLPE 422 LSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPFLSLPE Sbjct: 202 LSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPFLSLPE 241 >gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens] Length = 590 Score = 333 bits (855), Expect = 1e-91 Identities = 163/163 (100%), Positives = 163/163 (100%) Query: 249 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 308 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG Sbjct: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72 Query: 309 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEK 368 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEK Sbjct: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEK 132 Query: 369 TFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY 411 TFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY Sbjct: 133 TFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY 175 >gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens] Length = 607 Score = 323 bits (827), Expect = 2e-88 Identities = 163/180 (90%), Positives = 163/180 (90%), Gaps = 17/180 (9%) Query: 249 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 308 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG Sbjct: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72 Query: 309 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-----------------ATS 351 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN ATS Sbjct: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSATS 132 Query: 352 TSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY 411 TSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY Sbjct: 133 TSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY 192 >gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens] Length = 459 Score = 316 bits (809), Expect = 3e-86 Identities = 165/209 (78%), Positives = 167/209 (79%), Gaps = 34/209 (16%) Query: 237 KKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 296 KK S + ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN Sbjct: 22 KKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81 Query: 297 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------- 348 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN Sbjct: 82 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 141 Query: 349 --------------------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 382 +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD Sbjct: 142 STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 201 Query: 383 LSNPSRYLCKCPNEFTGDRCQNYVMASFY 411 LSNPSRYLCKCPNEFTGDRCQNYVMASFY Sbjct: 202 LSNPSRYLCKCPNEFTGDRCQNYVMASFY 230 >gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens] Length = 420 Score = 316 bits (809), Expect = 3e-86 Identities = 165/209 (78%), Positives = 167/209 (79%), Gaps = 34/209 (16%) Query: 237 KKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 296 KK S + ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN Sbjct: 22 KKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81 Query: 297 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------- 348 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN Sbjct: 82 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 141 Query: 349 --------------------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 382 +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD Sbjct: 142 STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 201 Query: 383 LSNPSRYLCKCPNEFTGDRCQNYVMASFY 411 LSNPSRYLCKCPNEFTGDRCQNYVMASFY Sbjct: 202 LSNPSRYLCKCPNEFTGDRCQNYVMASFY 230 >gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens] Length = 637 Score = 316 bits (809), Expect = 3e-86 Identities = 165/209 (78%), Positives = 167/209 (79%), Gaps = 34/209 (16%) Query: 237 KKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 296 KK S + ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN Sbjct: 22 KKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81 Query: 297 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------- 348 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN Sbjct: 82 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 141 Query: 349 --------------------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 382 +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD Sbjct: 142 STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 201 Query: 383 LSNPSRYLCKCPNEFTGDRCQNYVMASFY 411 LSNPSRYLCKCPNEFTGDRCQNYVMASFY Sbjct: 202 LSNPSRYLCKCPNEFTGDRCQNYVMASFY 230 >gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens] Length = 645 Score = 316 bits (809), Expect = 3e-86 Identities = 165/209 (78%), Positives = 167/209 (79%), Gaps = 34/209 (16%) Query: 237 KKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 296 KK S + ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN Sbjct: 22 KKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81 Query: 297 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------- 348 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN Sbjct: 82 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 141 Query: 349 --------------------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 382 +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD Sbjct: 142 STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 201 Query: 383 LSNPSRYLCKCPNEFTGDRCQNYVMASFY 411 LSNPSRYLCKCPNEFTGDRCQNYVMASFY Sbjct: 202 LSNPSRYLCKCPNEFTGDRCQNYVMASFY 230 >gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens] Length = 624 Score = 315 bits (807), Expect = 5e-86 Identities = 162/197 (82%), Positives = 163/197 (82%), Gaps = 34/197 (17%) Query: 249 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 308 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG Sbjct: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72 Query: 309 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------------------- 348 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN Sbjct: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 132 Query: 349 --------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 394 +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP Sbjct: 133 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 192 Query: 395 NEFTGDRCQNYVMASFY 411 NEFTGDRCQNYVMASFY Sbjct: 193 NEFTGDRCQNYVMASFY 209 >gi|236464356 neuregulin 1 isoform HRG-gamma3 [Homo sapiens] Length = 177 Score = 291 bits (745), Expect = 8e-79 Identities = 147/156 (94%), Positives = 148/156 (94%) Query: 237 KKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 296 KK S + ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN Sbjct: 22 KKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81 Query: 297 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTG 356 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTG Sbjct: 82 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTG 141 Query: 357 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 392 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK Sbjct: 142 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 177 >gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens] Length = 640 Score = 286 bits (731), Expect = 3e-77 Identities = 153/204 (75%), Positives = 155/204 (75%), Gaps = 34/204 (16%) Query: 237 KKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 296 KK S + ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN Sbjct: 22 KKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81 Query: 297 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------- 348 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN Sbjct: 82 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 141 Query: 349 --------------------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 382 +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD Sbjct: 142 STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 201 Query: 383 LSNPSRYLCKCPNEFTGDRCQNYV 406 LSNPSRYLCKC FTG RC V Sbjct: 202 LSNPSRYLCKCQPGFTGARCTENV 225 >gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens] Length = 462 Score = 286 bits (731), Expect = 3e-77 Identities = 153/204 (75%), Positives = 155/204 (75%), Gaps = 34/204 (16%) Query: 237 KKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 296 KK S + ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN Sbjct: 22 KKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81 Query: 297 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------- 348 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN Sbjct: 82 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 141 Query: 349 --------------------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 382 +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD Sbjct: 142 STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 201 Query: 383 LSNPSRYLCKCPNEFTGDRCQNYV 406 LSNPSRYLCKC FTG RC V Sbjct: 202 LSNPSRYLCKCQPGFTGARCTENV 225 >gi|236462984 neuregulin 1 isoform HRG-gamma2 [Homo sapiens] Length = 194 Score = 280 bits (717), Expect = 1e-75 Identities = 147/173 (84%), Positives = 148/173 (85%), Gaps = 17/173 (9%) Query: 237 KKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 296 KK S + ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN Sbjct: 22 KKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81 Query: 297 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------- 348 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN Sbjct: 82 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 141 Query: 349 ---------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 392 ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK Sbjct: 142 STEGAYVSSATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 194 >gi|116006965 neuregulin 1 isoform HRG-gamma [Homo sapiens] Length = 211 Score = 273 bits (697), Expect = 3e-73 Identities = 146/190 (76%), Positives = 148/190 (77%), Gaps = 34/190 (17%) Query: 237 KKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 296 KK S + ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN Sbjct: 22 KKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81 Query: 297 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------- 348 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN Sbjct: 82 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 141 Query: 349 --------------------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 382 +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD Sbjct: 142 STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 201 Query: 383 LSNPSRYLCK 392 LSNPSRYLCK Sbjct: 202 LSNPSRYLCK 211 >gi|7669528 neuregulin 2 isoform 2 [Homo sapiens] Length = 844 Score = 196 bits (498), Expect = 3e-50 Identities = 141/418 (33%), Positives = 208/418 (49%), Gaps = 92/418 (22%) Query: 9 RSGRPGPRAQRPGSAARSSP---PLPLLPLLLLLGTAALAPGAAAGN---EAAPA----- 57 RS RP + P P P P AA + AAAG + AP Sbjct: 48 RSSSNNSSISRPAAPPEPRPQQQPQPRSPAARR--AAARSRAAAAGGMRRDPAPGFSMLL 105 Query: 58 -GASV-CYSSPPSVGSVQELAQRAAVVIEGKVHPQRRQQGALDRKAAAAAGEAGAWGGDR 115 G S+ CYS PS+ SVQ+ A +A VV+EGKV QG + +++ R Sbjct: 106 FGVSLACYS--PSLKSVQDQAYKAPVVVEGKV------QGLVPAGGSSS-------NSTR 150 Query: 116 EPPAAGPRALGPPAEEPLLAANGTVPSWPTAPVPSAGEPGEEAPYLVKVHQVWAVKAGGL 175 EPPA+G AL VKV W +++GGL Sbjct: 151 EPPASGRVAL------------------------------------VKVLDKWPLRSGGL 174 Query: 176 KKDSLLTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFRASFPPLET-GR 234 +++ +++V SC L+ + RYIFF+EP + P F+ +F PL+T G+ Sbjct: 175 QREQVISVG----------SCVPLERNQRYIFFLEP-----TEQPLVFKTAFAPLDTNGK 219 Query: 235 NLKKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNR 294 NLKKEV ++LC CA P+LK+MKSQ G K L+CE ++ ++WFK+G ELNR Sbjct: 220 NLKKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNR 279 Query: 295 KNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATST 352 ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ + + + T + Sbjct: 280 S---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLS 336 Query: 353 STTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF 410 S +G H KC E K++CVNGG C+ ++ ++ S CKCP +TGDRCQ + M +F Sbjct: 337 SWSG--HARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVNF 389 >gi|7669532 neuregulin 2 isoform 4 [Homo sapiens] Length = 852 Score = 196 bits (498), Expect = 3e-50 Identities = 141/418 (33%), Positives = 208/418 (49%), Gaps = 92/418 (22%) Query: 9 RSGRPGPRAQRPGSAARSSP---PLPLLPLLLLLGTAALAPGAAAGN---EAAPA----- 57 RS RP + P P P P AA + AAAG + AP Sbjct: 48 RSSSNNSSISRPAAPPEPRPQQQPQPRSPAARR--AAARSRAAAAGGMRRDPAPGFSMLL 105 Query: 58 -GASV-CYSSPPSVGSVQELAQRAAVVIEGKVHPQRRQQGALDRKAAAAAGEAGAWGGDR 115 G S+ CYS PS+ SVQ+ A +A VV+EGKV QG + +++ R Sbjct: 106 FGVSLACYS--PSLKSVQDQAYKAPVVVEGKV------QGLVPAGGSSS-------NSTR 150 Query: 116 EPPAAGPRALGPPAEEPLLAANGTVPSWPTAPVPSAGEPGEEAPYLVKVHQVWAVKAGGL 175 EPPA+G AL VKV W +++GGL Sbjct: 151 EPPASGRVAL------------------------------------VKVLDKWPLRSGGL 174 Query: 176 KKDSLLTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFRASFPPLET-GR 234 +++ +++V SC L+ + RYIFF+EP + P F+ +F PL+T G+ Sbjct: 175 QREQVISVG----------SCVPLERNQRYIFFLEP-----TEQPLVFKTAFAPLDTNGK 219 Query: 235 NLKKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNR 294 NLKKEV ++LC CA P+LK+MKSQ G K L+CE ++ ++WFK+G ELNR Sbjct: 220 NLKKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNR 279 Query: 295 KNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATST 352 ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ + + + T + Sbjct: 280 S---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLS 336 Query: 353 STTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF 410 S +G H KC E K++CVNGG C+ ++ ++ S CKCP +TGDRCQ + M +F Sbjct: 337 SWSG--HARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVNF 389 >gi|7669530 neuregulin 2 isoform 3 [Homo sapiens] Length = 858 Score = 188 bits (477), Expect = 9e-48 Identities = 138/410 (33%), Positives = 202/410 (49%), Gaps = 92/410 (22%) Query: 9 RSGRPGPRAQRPGSAARSSP---PLPLLPLLLLLGTAALAPGAAAGN---EAAPA----- 57 RS RP + P P P P AA + AAAG + AP Sbjct: 48 RSSSNNSSISRPAAPPEPRPQQQPQPRSPAARR--AAARSRAAAAGGMRRDPAPGFSMLL 105 Query: 58 -GASV-CYSSPPSVGSVQELAQRAAVVIEGKVHPQRRQQGALDRKAAAAAGEAGAWGGDR 115 G S+ CYS PS+ SVQ+ A +A VV+EGKV QG + +++ R Sbjct: 106 FGVSLACYS--PSLKSVQDQAYKAPVVVEGKV------QGLVPAGGSSS-------NSTR 150 Query: 116 EPPAAGPRALGPPAEEPLLAANGTVPSWPTAPVPSAGEPGEEAPYLVKVHQVWAVKAGGL 175 EPPA+G AL VKV W +++GGL Sbjct: 151 EPPASGRVAL------------------------------------VKVLDKWPLRSGGL 174 Query: 176 KKDSLLTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFRASFPPLET-GR 234 +++ +++V SC L+ + RYIFF+EP + P F+ +F PL+T G+ Sbjct: 175 QREQVISVG----------SCVPLERNQRYIFFLEP-----TEQPLVFKTAFAPLDTNGK 219 Query: 235 NLKKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNR 294 NLKKEV ++LC CA P+LK+MKSQ G K L+CE ++ ++WFK+G ELNR Sbjct: 220 NLKKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNR 279 Query: 295 KNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATST 352 ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ + + + T + Sbjct: 280 S---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLS 336 Query: 353 STTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRC 402 S +G H KC E K++CVNGG C+ ++ ++ S CKCPN F G RC Sbjct: 337 SWSG--HARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPNGFFGQRC 381 >gi|4758832 neuregulin 2 isoform 1 [Homo sapiens] Length = 850 Score = 188 bits (477), Expect = 9e-48 Identities = 138/410 (33%), Positives = 202/410 (49%), Gaps = 92/410 (22%) Query: 9 RSGRPGPRAQRPGSAARSSP---PLPLLPLLLLLGTAALAPGAAAGN---EAAPA----- 57 RS RP + P P P P AA + AAAG + AP Sbjct: 48 RSSSNNSSISRPAAPPEPRPQQQPQPRSPAARR--AAARSRAAAAGGMRRDPAPGFSMLL 105 Query: 58 -GASV-CYSSPPSVGSVQELAQRAAVVIEGKVHPQRRQQGALDRKAAAAAGEAGAWGGDR 115 G S+ CYS PS+ SVQ+ A +A VV+EGKV QG + +++ R Sbjct: 106 FGVSLACYS--PSLKSVQDQAYKAPVVVEGKV------QGLVPAGGSSS-------NSTR 150 Query: 116 EPPAAGPRALGPPAEEPLLAANGTVPSWPTAPVPSAGEPGEEAPYLVKVHQVWAVKAGGL 175 EPPA+G AL VKV W +++GGL Sbjct: 151 EPPASGRVAL------------------------------------VKVLDKWPLRSGGL 174 Query: 176 KKDSLLTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFRASFPPLET-GR 234 +++ +++V SC L+ + RYIFF+EP + P F+ +F PL+T G+ Sbjct: 175 QREQVISVG----------SCVPLERNQRYIFFLEP-----TEQPLVFKTAFAPLDTNGK 219 Query: 235 NLKKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNR 294 NLKKEV ++LC CA P+LK+MKSQ G K L+CE ++ ++WFK+G ELNR Sbjct: 220 NLKKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNR 279 Query: 295 KNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATST 352 ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ + + + T + Sbjct: 280 S---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLS 336 Query: 353 STTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRC 402 S +G H KC E K++CVNGG C+ ++ ++ S CKCPN F G RC Sbjct: 337 SWSG--HARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPNGFFGQRC 381 >gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens] Length = 296 Score = 160 bits (405), Expect = 2e-39 Identities = 74/86 (86%), Positives = 77/86 (89%) Query: 337 SASANITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNE 396 + N+ +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNE Sbjct: 211 TTETNLQTAPKLSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNE 270 Query: 397 FTGDRCQNYVMASFYSTSTPFLSLPE 422 FTGDRCQNYVMASFYSTSTPFLSLPE Sbjct: 271 FTGDRCQNYVMASFYSTSTPFLSLPE 296 >gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens] Length = 308 Score = 112 bits (280), Expect = 6e-25 Identities = 53/66 (80%), Positives = 56/66 (84%) Query: 341 NITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGD 400 +I+I + ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC FTG Sbjct: 6 HISIEDITATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGA 65 Query: 401 RCQNYV 406 RC V Sbjct: 66 RCTENV 71 >gi|115298665 neurotrimin isoform 2 [Homo sapiens] Length = 344 Score = 55.8 bits (133), Expect = 7e-08 Identities = 37/113 (32%), Positives = 53/113 (46%), Gaps = 5/113 (4%) Query: 251 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310 PP + E K G K L+CE S+ S F+W+K+ L K +K++ +P S Sbjct: 222 PPYISEAKGTGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK--GVKVENRPFLS 278 Query: 311 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKC 363 +L S D G Y C +KLG+ +AS I + A S + GTS C Sbjct: 279 KLIFFNVSEHDYGNYTCVASNKLGHTNAS--IMLFGPGAVSEVSNGTSRRAGC 329 >gi|7705413 neurotrimin isoform 1 [Homo sapiens] Length = 344 Score = 55.8 bits (133), Expect = 7e-08 Identities = 37/113 (32%), Positives = 53/113 (46%), Gaps = 5/113 (4%) Query: 251 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310 PP + E K G K L+CE S+ S F+W+K+ L K +K++ +P S Sbjct: 222 PPYISEAKGTGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK--GVKVENRPFLS 278 Query: 311 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKC 363 +L S D G Y C +KLG+ +AS I + A S + GTS C Sbjct: 279 KLIFFNVSEHDYGNYTCVASNKLGHTNAS--IMLFGPGAVSEVSNGTSRRAGC 329 >gi|110349719 titin isoform N2-A [Homo sapiens] Length = 33423 Score = 54.3 bits (129), Expect = 2e-07 Identities = 50/186 (26%), Positives = 78/186 (41%), Gaps = 35/186 (18%) Query: 249 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 308 A P ++++ E A G CE S ++RF+WFK G E+ +K I+ Sbjct: 3454 AAPVIKRKIEPLEVALGHLAKFTCEIQSA-PNVRFQWFKAGREIYESDK---CSIRSSKY 3509 Query: 309 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVE-------SNATSTST------- 354 S L I + + D GEY CK ++ G+ S +A +T+ E S S +T Sbjct: 3510 ISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAK 3569 Query: 355 -----TGTSHLVKCAEKE-------KTFCVNGGECFMVKDLSN-----PSRYLCKCPNEF 397 TGT + +K+ + ++ E + +LSN Y CK N+F Sbjct: 3570 FICTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKF 3629 Query: 398 TGDRCQ 403 D CQ Sbjct: 3630 GADICQ 3635 Score = 52.0 bits (123), Expect = 1e-06 Identities = 42/190 (22%), Positives = 76/190 (40%), Gaps = 34/190 (17%) Query: 250 LPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 308 +PP K++ + GS + + C+ S + +WFK+G E++ K + + ++ Sbjct: 5235 IPPSFTKKLTKMDKVLGSSIHMECKVSGSLP-ISAQWFKDGKEISTSAKYRLVCHERSVS 5293 Query: 309 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVE----------SNATSTSTTGTS 358 L +N L D+ Y CKV + G+D+ S +T+ E A ST Sbjct: 5294 ---LEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVKPGRQQAIPDSTVEFK 5350 Query: 359 HLVKCAE-------KEKTFCVNGGECFM------------VKDLSNPSRYLCKCPNEFTG 399 ++K K+ V+G +CF+ D S +Y C N+ Sbjct: 5351 AILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGS 5410 Query: 400 DRCQNYVMAS 409 D C ++ + Sbjct: 5411 DSCTTMLLVT 5420 Score = 47.8 bits (112), Expect = 2e-05 Identities = 31/118 (26%), Positives = 55/118 (46%), Gaps = 11/118 (9%) Query: 236 LKKEVSRVLCKR------CALPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKN 288 ++ +V R CK +PP K++K +S GS + L C + + + +WFK+ Sbjct: 4653 VQNDVGRSSCKARINVLDLIIPPSFTKKLKKMDSIKGSFIDLECIVAGSHP-ISIQWFKD 4711 Query: 289 GNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346 E++ K K + L I++ DSG Y C +K G++ S ++T+ E Sbjct: 4712 DQEISASEK---YKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKE 4766 Score = 46.6 bits (109), Expect = 4e-05 Identities = 27/100 (27%), Positives = 44/100 (44%), Gaps = 4/100 (4%) Query: 247 RCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 306 R P +++K +GS +V+ C+ + WF GNE++ K Q Sbjct: 7678 RTVPPSFTRKLKETNGLSGSSVVMECKVYGS-PPISVSWFHEGNEISSGRKYQTTLTDNT 7736 Query: 307 PGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346 L +N +DSG+Y C + G+D SA +T+ E Sbjct: 7737 ---CALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVRE 7773 Score = 46.6 bits (109), Expect = 4e-05 Identities = 28/95 (29%), Positives = 48/95 (50%), Gaps = 4/95 (4%) Query: 251 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310 P + + +SQ G ++ CE S E S +WFKN ++ + N+ I + Sbjct: 33134 PAFISQPRSQNINEGQNVLFTCEISGEPSP-EIEWFKNNLPISISS---NVSISRSRNVY 33189 Query: 311 ELRINKASLADSGEYMCKVISKLGNDSASANITIV 345 L I AS++DSG+Y K + G SA+A++ ++ Sbjct: 33190 SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVL 33224 Score = 46.2 bits (108), Expect = 6e-05 Identities = 33/121 (27%), Positives = 57/121 (47%), Gaps = 5/121 (4%) Query: 251 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310 P +KE++ +SA K+ L C+ + + W K+G +L ++ KI + + Sbjct: 3644 PHFIKELEPVQSAINKKVHLECQVDED-RKVTVTWSKDGQKLP---PGKDYKICFEDKIA 3699 Query: 311 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTF 370 L I A L DSG Y+C ++ G+ S SA +T+ E + S+L+ E + Sbjct: 3700 TLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREP-PSFVKKVDPSYLMLPGESARLH 3758 Query: 371 C 371 C Sbjct: 3759 C 3759 Score = 45.8 bits (107), Expect = 7e-05 Identities = 42/186 (22%), Positives = 72/186 (38%), Gaps = 33/186 (17%) Query: 251 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310 P ++E+K E S + L CE + W KN E+ K + + Sbjct: 4955 PTFIRELKPVEVVKYSDVELECEVTGT-PPFEVTWLKNNREIRSSKK---YTLTDRVSVF 5010 Query: 311 ELRINKASLADSGEYMCKVISKLGNDSASANI----------------TIVESNATSTST 354 L I K +D+GEY C V ++ G+ S S + T+++S+AT ST Sbjct: 5011 NLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQST 5070 Query: 355 TGTSHLVKCA---------EKEKTFC--VNGGECFMVKDLSN--PSRYLCKCPNEFTGDR 401 S + E + + V+ ++ + N RY C+ NE +R Sbjct: 5071 VAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVER 5130 Query: 402 CQNYVM 407 C +++ Sbjct: 5131 CYAFLL 5136 Score = 44.7 bits (104), Expect = 2e-04 Identities = 29/96 (30%), Positives = 53/96 (55%), Gaps = 6/96 (6%) Query: 251 PPR-LKEMKSQESAA-GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 308 PP+ +K++++ + A G + L C+ S ++ WF+N +EL+ K I Sbjct: 6363 PPKFVKKLEASKVAKQGESIQLECKISGS-PEIKVSWFRNDSELHESWKYNMSFINSV-- 6419 Query: 309 KSELRINKASLADSGEYMCKVISKLGNDSASANITI 344 + L IN+AS DSG+Y+C+ + +G+ S S +T+ Sbjct: 6420 -ALLTINEASAEDSGDYICEAHNGVGDASCSTALTV 6454 Score = 44.7 bits (104), Expect = 2e-04 Identities = 27/78 (34%), Positives = 40/78 (51%), Gaps = 10/78 (12%) Query: 267 KLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM 326 ++ L+CE S + + KWFK+G E+ K I+ + L+I KA L D GEY+ Sbjct: 11679 EITLKCEVSKD---VPVKWFKDGEEIVPSPK---YSIKADGLRRILKIKKADLKDKGEYV 11732 Query: 327 CKVISKLGNDSASANITI 344 C G D AN+T+ Sbjct: 11733 C----DCGTDKTKANVTV 11746 Score = 44.3 bits (103), Expect = 2e-04 Identities = 24/89 (26%), Positives = 45/89 (50%), Gaps = 9/89 (10%) Query: 281 LRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASA 340 ++ WFKN EL+ N +++ ++ L I + DSG Y C+ ++ +G+DS S Sbjct: 3767 IQVTWFKNNKELSESN---TVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCST 3823 Query: 341 NITI------VESNATSTSTTGTSHLVKC 363 I I +++ + GT+ L++C Sbjct: 3824 EIVIKEPPSFIKTLEPADIVRGTNALLQC 3852 Score = 44.3 bits (103), Expect = 2e-04 Identities = 31/112 (27%), Positives = 49/112 (43%), Gaps = 5/112 (4%) Query: 251 PPRLKEMKSQESAA-GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 309 PP + S A GS ++L+CE S W K+ ++ K KI K Sbjct: 6457 PPVFTQKPSPVGALKGSDVILQCEISGT-PPFEVVWVKDRKQVRNSKK---FKITSKHFD 6512 Query: 310 SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLV 361 + L I +D GEY CK +++G+D+ S ++ E + TS L+ Sbjct: 6513 TSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKLSDTSTLI 6564 Score = 43.9 bits (102), Expect = 3e-04 Identities = 27/115 (23%), Positives = 52/115 (45%), Gaps = 5/115 (4%) Query: 241 SRVLCKRCALPPRLKEMKSQESAA-GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQ 299 S ++ K PP + + + + G + L C +R +W K G E+ ++ Sbjct: 8335 SSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGS-EPIRIQWLKAGREIKPSDR-- 8391 Query: 300 NIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST 354 G + L + + ADSG+Y+CK + G+D+ + +TI + A + +T Sbjct: 8392 -CSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPAT 8445 Score = 43.5 bits (101), Expect = 4e-04 Identities = 40/193 (20%), Positives = 75/193 (38%), Gaps = 33/193 (17%) Query: 239 EVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKP 298 E + + R P K +++ +S L C+ + +R WFK+G E+ ++ Sbjct: 4101 ETTFTVLDRDIAPFFTKPLRNVDSVVNGTCRLDCKIAGSLP-MRVSWFKDGKEIAASDR- 4158 Query: 299 QNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE------------ 346 +I G + L I + + D+G + C+ + +G+ +S + + E Sbjct: 4159 --YRIAFVEGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKD 4216 Query: 347 ---SNATSTSTT--GTSHLVKCAEKEKTFCVNGGECFMVKD------------LSNPSRY 389 +A +T G++ L K V+GG C++ K+ S+ Y Sbjct: 4217 VLPGSAVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTY 4276 Query: 390 LCKCPNEFTGDRC 402 CK N G C Sbjct: 4277 TCKVSNVAGGVEC 4289 Score = 43.1 bits (100), Expect = 5e-04 Identities = 34/140 (24%), Positives = 58/140 (41%), Gaps = 35/140 (25%) Query: 209 MEPDANSTSRAPAAFRASFPPLETGRNLKK-EVSRVLCKRCALPPRLKEMKSQESAAGSK 267 +E AN + PA F LE + LKK + +++ CK PP Sbjct: 4287 VECSANLFVKEPATF---VEKLEPSQLLKKGDATQLACKVTGTPP--------------- 4328 Query: 268 LVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMC 327 ++ WF N E+ +K + ++ + LR+ + DSGEYMC Sbjct: 4329 -------------IKITWFANDREIKESSKHRMSFVEST---AVLRLTDVGIEDSGEYMC 4372 Query: 328 KVISKLGNDSASANITIVES 347 + ++ G+D S+ + + ES Sbjct: 4373 EAQNEAGSDHCSSIVIVKES 4392 Score = 42.4 bits (98), Expect = 8e-04 Identities = 41/179 (22%), Positives = 68/179 (37%), Gaps = 34/179 (18%) Query: 259 SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKAS 318 S++ GS + L+ T + L +WFK EL + I K+ +S L + Sbjct: 4214 SKDVLPGSAVCLK-STFQGSTPLTIRWFKGNKELVSGG---SCYITKEALESSLELYLVK 4269 Query: 319 LADSGEYMCKVISKLGNDSASANITIVE------------------SNATSTSTTGTSHL 360 +DSG Y CKV + G SAN+ + E + + TGT + Sbjct: 4270 TSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQLLKKGDATQLACKVTGTPPI 4329 Query: 361 ----------VKCAEKEKTFCVNGGECFMVKD--LSNPSRYLCKCPNEFTGDRCQNYVM 407 +K + K + V + D + + Y+C+ NE D C + V+ Sbjct: 4330 KITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVI 4388 Score = 42.4 bits (98), Expect = 8e-04 Identities = 28/107 (26%), Positives = 50/107 (46%), Gaps = 4/107 (3%) Query: 240 VSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQ 299 VS + R P ++++K + G+ +VL C S + + WF++GNE+ K Q Sbjct: 6730 VSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVSGS-APISVGWFQDGNEIVSGPKCQ 6788 Query: 300 NIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346 + L ++ +D+G Y C + G+D SA +T+ E Sbjct: 6789 S---SFSENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQE 6832 Score = 42.4 bits (98), Expect = 8e-04 Identities = 32/119 (26%), Positives = 57/119 (47%), Gaps = 13/119 (10%) Query: 254 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 313 +++ +S + G L C T + L KWFK+G EL NK + K G L+ Sbjct: 7589 VEKPESIKVTTGDTCTLEC-TVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSG---LK 7644 Query: 314 INKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST---------TGTSHLVKC 363 I + +DSG Y +V + +G DS +A++ + + + T +G+S +++C Sbjct: 7645 IINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMEC 7703 Score = 41.6 bits (96), Expect = 0.001 Identities = 27/94 (28%), Positives = 47/94 (50%), Gaps = 4/94 (4%) Query: 251 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310 P ++ ++ E+ G L+C+ +R W+K +L ++ P K+Q K + Sbjct: 7020 PYFIEPLEHVEAVIGEPATLQCKVDGT-PEIRISWYKEHTKL--RSAPA-YKMQFKNNVA 7075 Query: 311 ELRINKASLADSGEYMCKVISKLGNDSASANITI 344 L INK +D GEY CK + +G ++SA + I Sbjct: 7076 SLVINKVDHSDVGEYSCKADNSVGAVASSAVLVI 7109 Score = 40.8 bits (94), Expect = 0.002 Identities = 26/98 (26%), Positives = 48/98 (48%), Gaps = 5/98 (5%) Query: 250 LPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 308 LPP +++K E G + L C + + ++ W+++G L +N++ Sbjct: 6173 LPPSFARQLKDIEQTVGLPVTLTCRLNGS-APIQVCWYRDGVLLR---DDENLQTSFVDN 6228 Query: 309 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346 + L+I + L+ SG+Y C + LG S+SA +T E Sbjct: 6229 VATLKILQTDLSHSGQYSCSASNPLGTASSSARLTARE 6266 Score = 40.8 bits (94), Expect = 0.002 Identities = 24/96 (25%), Positives = 46/96 (47%), Gaps = 4/96 (4%) Query: 251 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310 P +K+++ + + G L+C+ + + W+K +L K+ + + Sbjct: 7961 PYFVKQLEPVKVSVGDSASLQCQLAGT-PEIGVSWYKGDTKLRPTT---TYKMHFRNNVA 8016 Query: 311 ELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346 L N+ + DSGEY+CK + +G SAS +T+ E Sbjct: 8017 TLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQE 8052 Score = 40.4 bits (93), Expect = 0.003 Identities = 29/120 (24%), Positives = 56/120 (46%), Gaps = 10/120 (8%) Query: 251 PPR-LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 309 PPR +K++ + G + LR + + W K+ E+ R++ +N +I Sbjct: 6550 PPRFVKKLSDTSTLIGDAVELRAIVEG-FQPISVVWLKDRGEVIRES--ENTRISFIDNI 6606 Query: 310 SELRINKASLADSGEYMCKVISKLGNDSASANIT------IVESNATSTSTTGTSHLVKC 363 + L++ ++SG+Y+C++ + G SA +T I+E T TTG ++C Sbjct: 6607 ATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALEC 6666 Score = 40.4 bits (93), Expect = 0.003 Identities = 31/119 (26%), Positives = 52/119 (43%), Gaps = 8/119 (6%) Query: 251 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310 PPR + S S K V T + WFK+ E+ R++ NI I + Sbjct: 7491 PPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRES--DNIWISYSENIA 7548 Query: 311 ELRINKASLADSGEYMCKVISKLGNDSASANI------TIVESNATSTSTTGTSHLVKC 363 L+ ++ A++G+Y C++ + G A + TIVE + TTG + ++C Sbjct: 7549 TLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLEC 7607 Score = 39.7 bits (91), Expect = 0.005 Identities = 33/133 (24%), Positives = 53/133 (39%), Gaps = 9/133 (6%) Query: 214 NSTSRAPAAFRASFPPLETGRNLKKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCE 273 NST R + E GR +V L P + E++ E+A G + L+C+ Sbjct: 6047 NSTKRDAGQYSCEIEN-EAGR----DVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQ 6101 Query: 274 TSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKL 333 + + W+K +L + + L NK ++ DSGEY CK + + Sbjct: 6102 VAGT-PEITVSWYKGDTKLR---PTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSI 6157 Query: 334 GNDSASANITIVE 346 G S+ I E Sbjct: 6158 GTASSKTVFRIQE 6170 Score = 39.7 bits (91), Expect = 0.005 Identities = 24/105 (22%), Positives = 46/105 (43%), Gaps = 4/105 (3%) Query: 261 ESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLA 320 ++ G C + ++ W K+ E+ K Q ++ + L+++K Sbjct: 8163 DAVVGESADFECHVTGT-QPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKG--- 8218 Query: 321 DSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAE 365 DSG+Y C ++++G DS +A + I E + T S V+ E Sbjct: 8219 DSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETE 8263 Score = 39.3 bits (90), Expect = 0.007 Identities = 30/109 (27%), Positives = 47/109 (43%), Gaps = 8/109 (7%) Query: 245 CKRCALPPRLKEMKS-QESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 303 C +PP ++ ++ + K + R E + + KWFK+G E+ + K I Sbjct: 12365 CNLNVVPPHVEFLRPLTDLQVREKEMARFECELSRENAKVKWFKDGAEIKKGKK---YDI 12421 Query: 304 QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATST 352 K L INK L D EY C+V + S +T++E A T Sbjct: 12422 ISKGAVRILVINKCLLDDEAEYSCEVRTA----RTSGMLTVLEEEAVFT 12466 Score = 38.9 bits (89), Expect = 0.009 Identities = 28/120 (23%), Positives = 49/120 (40%), Gaps = 6/120 (5%) Query: 251 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310 P + +K+ G + L C S Y S W++ ++ + +I + G + Sbjct: 943 PTLVSGLKNVTVIEGESVTLECHISG-YPSPTVTWYREDYQIESSI---DFQITFQSGIA 998 Query: 311 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTF 370 L I +A DSG + C +++ G S S + + S TT + K +EK F Sbjct: 999 RLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE--KFTTEEKRF 1056 Score = 38.9 bits (89), Expect = 0.009 Identities = 25/79 (31%), Positives = 39/79 (49%), Gaps = 6/79 (7%) Query: 285 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT- 343 W K+G + + K K+ + G L I+K +DSG Y C V + G+ S+S +T Sbjct: 32885 WTKDGKAITQGGK---YKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 32941 Query: 344 --IVESNATSTSTTGTSHL 360 I ++ A ST TS + Sbjct: 32942 KAIKDTEAQKVSTQKTSEI 32960 Score = 38.5 bits (88), Expect = 0.012 Identities = 23/63 (36%), Positives = 32/63 (50%), Gaps = 3/63 (4%) Query: 284 KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 343 KWFK+G EL +K KI S L+I DSGEY +V + +G S A I Sbjct: 4611 KWFKDGQELTLGSK---YKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARIN 4667 Query: 344 IVE 346 +++ Sbjct: 4668 VLD 4670 Score = 38.5 bits (88), Expect = 0.012 Identities = 25/98 (25%), Positives = 51/98 (52%), Gaps = 6/98 (6%) Query: 251 PPR-LKEMKSQESA-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 308 PP+ +K++++ + AG L C+ + +R WF+N +EL +K + I Sbjct: 5422 PPKFVKKLEASKIVKAGDSSRLECKIAGS-PEIRVVWFRNEHELPASDKYRMTFIDSV-- 5478 Query: 309 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346 + +++N S DSG+++C+ + G+ S S + + E Sbjct: 5479 -AVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKE 5515 Score = 38.5 bits (88), Expect = 0.012 Identities = 23/84 (27%), Positives = 37/84 (44%), Gaps = 4/84 (4%) Query: 261 ESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLA 320 E+ G+ + L CE W+K+ EL K KI + + + I A Sbjct: 7409 ETLKGADVHLECELQGT-PPFHVSWYKDKRELRSGKK---YKIMSENFLTSIHILNVDAA 7464 Query: 321 DSGEYMCKVISKLGNDSASANITI 344 D GEY CK + +G+D+ +I + Sbjct: 7465 DIGEYQCKATNDVGSDTCVGSIAL 7488 Score = 38.1 bits (87), Expect = 0.015 Identities = 31/106 (29%), Positives = 47/106 (44%), Gaps = 4/106 (3%) Query: 255 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 314 KE K E ++L E + WFK+ N + R + IQ L+I Sbjct: 4397 KEFKPIEVLKEYDVMLLAEVAGT-PPFEITWFKD-NTILRSGRKYKTFIQDH--LVSLQI 4452 Query: 315 NKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHL 360 K AD+GEY C+V +++G+ SA +T+ E + TS L Sbjct: 4453 LKFVAADAGEYQCRVTNEVGSSICSARVTLREPPSFIKKIESTSSL 4498 Score = 38.1 bits (87), Expect = 0.015 Identities = 25/98 (25%), Positives = 44/98 (44%), Gaps = 10/98 (10%) Query: 249 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 308 + PP ++ +K+ E + L CE S W+K+ +L K KI K Sbjct: 5521 SFPPIVETLKNAEVS------LECELSGT-PPFEVVWYKDKRQLRSSKK---YKIASKNF 5570 Query: 309 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346 + + I +D GEY CK +++G+D+ + + E Sbjct: 5571 HTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKE 5608 Score = 37.7 bits (86), Expect = 0.020 Identities = 18/70 (25%), Positives = 31/70 (44%) Query: 285 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 344 W+K+G ++ + + + G +L IN + D EY +K G DS A +T+ Sbjct: 31723 WYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 31782 Query: 345 VESNATSTST 354 + ST Sbjct: 31783 TLHPPPTDST 31792 Score = 37.7 bits (86), Expect = 0.020 Identities = 46/197 (23%), Positives = 80/197 (40%), Gaps = 21/197 (10%) Query: 150 SAGEPGEEAPYLVKVHQVWAVKAGGLKKDSLLTVRLGTWGHPAFPSCGRLKEDSRYIFFM 209 S+ + +E Y V V G + + LT++ A S R+K + Sbjct: 32621 SSVQASDEGNYSVVVEN----SEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRV--K 32674 Query: 210 EPDANSTSRAPAAFRASFP----PLETGRNLKKEVSRVLCKRCALPPRLKEMKSQESAAG 265 P+A + + + S P P ET ++V + + PP++ + E+ Sbjct: 32675 SPEAVKSPKRVKSPEPSHPKAVSPTETKPTPTEKVQHL---PVSAPPKITQFLKAEA--- 32728 Query: 266 SKLVLRCETSSEYSSLRFK---WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADS 322 SK + + E S LR K W+K+G +L Q G EL+IN + +D Sbjct: 32729 SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH--YSADGTYELKINNLTESDQ 32786 Query: 323 GEYMCKVISKLGNDSAS 339 GEY+C++ + G + Sbjct: 32787 GEYVCEISGEGGTSKTN 32803 Score = 37.4 bits (85), Expect = 0.026 Identities = 23/83 (27%), Positives = 34/83 (40%), Gaps = 4/83 (4%) Query: 264 AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSG 323 AG C + +R W K+ E+ N I LRI K DSG Sbjct: 6284 AGESADFECHVTGA-QPMRITWSKDNKEIRPGG---NYTITCVGNTPHLRILKVGKGDSG 6339 Query: 324 EYMCKVISKLGNDSASANITIVE 346 +Y C+ + +G D SA +++ E Sbjct: 6340 QYTCQATNDVGKDMCSAQLSVKE 6362 Score = 37.4 bits (85), Expect = 0.026 Identities = 27/103 (26%), Positives = 46/103 (44%), Gaps = 6/103 (5%) Query: 246 KRCALPPRLKEMKSQ--ESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 303 K +PP + S+ E G+ L + + W+KN E+ + N +I Sbjct: 8243 KERLIPPSFTKRLSETVEETEGNSFKLEGRVAGS-QPITVAWYKNNIEIQPTS---NCEI 8298 Query: 304 QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346 K L++ KA + D+G Y CKV + G+ +++I I E Sbjct: 8299 TFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKE 8341 Score = 35.8 bits (81), Expect = 0.075 Identities = 32/128 (25%), Positives = 56/128 (43%), Gaps = 14/128 (10%) Query: 248 CALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLR------FKWFKNGNELNRKNKPQNI 301 C +LKE S S V+ E + +S+ +W K E+ R++ +NI Sbjct: 5600 CVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRES--ENI 5657 Query: 302 KIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANI------TIVESNATSTSTT 355 +I + L+ KA A++G+Y+C++ + G A + IVE T T Sbjct: 5658 RITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTV 5717 Query: 356 GTSHLVKC 363 G + ++C Sbjct: 5718 GETCTLEC 5725 Score = 35.4 bits (80), Expect = 0.098 Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 4/80 (5%) Query: 265 GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGE 324 G+ L C + L KWFK+G EL+ +K I K + L+I A ++D G Sbjct: 6659 GNPFALECVVTGT-PELSAKWFKDGRELSADSKHHITFINK---VASLKIPCAEMSDKGL 6714 Query: 325 YMCKVISKLGNDSASANITI 344 Y +V + +G + + ++ + Sbjct: 6715 YSFEVKNSVGKSNCTVSVHV 6734 Score = 35.4 bits (80), Expect = 0.098 Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 2/43 (4%) Query: 255 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNK 297 K ++ Q G+ VL CE S E + + KWFKNG E+ + K Sbjct: 12289 KPLEDQTVEEGATAVLECEVSRE--NAKVKWFKNGTEILKSKK 12329 Score = 35.0 bits (79), Expect = 0.13 Identities = 26/96 (27%), Positives = 43/96 (44%), Gaps = 4/96 (4%) Query: 251 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310 P +K ++ + G+ +L+CE S WFK+ ++ R +K + QK Sbjct: 3831 PSFIKTLEPADIVRGTNALLQCEVSGT-GPFEISWFKDKKQI-RSSKKYRLFSQKS--LV 3886 Query: 311 ELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346 L I + AD GEY C V +++G A + E Sbjct: 3887 CLEIFSFNSADVGEYECVVANEVGKCGCMATHLLKE 3922 Score = 35.0 bits (79), Expect = 0.13 Identities = 25/93 (26%), Positives = 40/93 (43%), Gaps = 4/93 (4%) Query: 254 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 313 +K + G L+L T + + W KNG + Q I + L Sbjct: 7871 VKRLNDYSIEKGKPLILE-GTFTGTPPISVTWKKNGINVTPS---QRCNITTTEKSAILE 7926 Query: 314 INKASLADSGEYMCKVISKLGNDSASANITIVE 346 I +++ D+G+Y C + + G DS SA I I+E Sbjct: 7927 IPSSTVEDAGQYNCYIENASGKDSCSAQILILE 7959 Score = 34.3 bits (77), Expect = 0.22 Identities = 23/99 (23%), Positives = 41/99 (41%), Gaps = 5/99 (5%) Query: 249 ALPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKP 307 A+PP + +K+ G+ +L C+ + S + WF ++ K Q Sbjct: 5797 AVPPSFTRRLKNTGGVLGASCILECKVAGS-SPISVAWFHEKTKIVSGAKYQTTF---SD 5852 Query: 308 GKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346 L++N +D G Y C + G+D A +T+ E Sbjct: 5853 NVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQE 5891 Score = 34.3 bits (77), Expect = 0.22 Identities = 28/117 (23%), Positives = 46/117 (39%), Gaps = 5/117 (4%) Query: 259 SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKAS 318 S + A G +C + + ++ W K+ E+ N K+ + L + K Sbjct: 7220 SVDLALGESGTFKCHVTGT-APIKITWAKDNREIRPGG---NYKMTLVENTATLTVLKVG 7275 Query: 319 LADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGG 375 D+G+Y C + G DS SA + + E S +VK E + C GG Sbjct: 7276 KGDAGQYTCYASNIAGKDSCSAQLGVQEP-PRFIKKLEPSRIVKQDEFTRYECKIGG 7331 Score = 33.9 bits (76), Expect = 0.29 Identities = 29/103 (28%), Positives = 43/103 (41%), Gaps = 7/103 (6%) Query: 255 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 314 K + Q A + V CE ++ S + +W ++G L N NI+ + K L I Sbjct: 2624 KPLTDQTVAESQEAVFECEVANPDS--KGEWLRDGKHLPLTN---NIRSESDGHKRRLII 2678 Query: 315 NKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGT 357 L D GEY KV + SA + V+ T + T T Sbjct: 2679 AATKLDDIGEYTYKVAT--SKTSAKLKVEAVKIKKTLKNLTVT 2719 Score = 33.9 bits (76), Expect = 0.29 Identities = 27/99 (27%), Positives = 41/99 (41%), Gaps = 5/99 (5%) Query: 249 ALPPR-LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKP 307 A PP L KS + G C T + + W K+G L+ N +I Sbjct: 3548 AYPPTFLSRPKSLTTFVGKAAKFIC-TVTGTPVIETIWQKDGAALSPS---PNWRISDAE 3603 Query: 308 GKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346 K L ++ ++ D G Y CK +K G D A + I++ Sbjct: 3604 NKHILELSNLTIQDRGVYSCKASNKFGADICQAELIIID 3642 Score = 33.5 bits (75), Expect = 0.37 Identities = 21/96 (21%), Positives = 46/96 (47%), Gaps = 4/96 (4%) Query: 251 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310 P +++ +SQ+ +++ L+ + + KWFK+ EL+ + K + Sbjct: 4768 PYFVEKPQSQDVNPNTRVQLKALVGGT-APMTIKWFKDNKELHSGAARS---VWKDDTST 4823 Query: 311 ELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346 L + A DSG Y+C++ + +G ++ A + + E Sbjct: 4824 SLELFAAKATDSGTYICQLSNDVGTATSKATLFVKE 4859 Score = 33.5 bits (75), Expect = 0.37 Identities = 30/121 (24%), Positives = 49/121 (40%), Gaps = 5/121 (4%) Query: 265 GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGE 324 G C+ + +R W+ +GNE+ K I G + +I+ A + +SG Sbjct: 4876 GQSTTFECQITGT-PKIRVSWYLDGNEITAIQKHG---ISFIDGLATFQISGARVENSGT 4931 Query: 325 YMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLS 384 Y+C+ + G S S + + E T +VK ++ E V G F V L Sbjct: 4932 YVCEARNDAGTASCSIELKVKEP-PTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLK 4990 Query: 385 N 385 N Sbjct: 4991 N 4991 Score = 33.5 bits (75), Expect = 0.37 Identities = 18/73 (24%), Positives = 33/73 (45%), Gaps = 3/73 (4%) Query: 272 CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 331 C+ + S + W+ +L K +I + G + L + + D G Y CKV++ Sbjct: 31589 CKIENYDQSTQVTWYFGVRQLENSEK---YEITYEDGVAILYVKDITKLDDGTYRCKVVN 31645 Query: 332 KLGNDSASANITI 344 G DS+ A + + Sbjct: 31646 DYGEDSSYAELFV 31658 Score = 33.5 bits (75), Expect = 0.37 Identities = 36/147 (24%), Positives = 57/147 (38%), Gaps = 15/147 (10%) Query: 210 EPDANSTSRAPAAFRASFPPLETGRNLKKEVS-RVLCKRCALPPRLKEMKSQESAAGSKL 268 E A++ ++ A S T R +K ++ R+L K PR + ESA S Sbjct: 32529 EHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTK-----PRSMTVYEGESARFS-- 32581 Query: 269 VLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCK 328 C+T E W + G L+ + Q + KS I+ +D G Y Sbjct: 32582 ---CDTDGEPVPT-VTWLRKGQVLSTSARHQ---VTTTKYKSTFEISSVQASDEGNYSVV 32634 Query: 329 VISKLGNDSASANITIVESNATSTSTT 355 V + G A +TI ++ T + T Sbjct: 32635 VENSEGKQEAEFTLTIQKARVTEKAVT 32661 Score = 33.1 bits (74), Expect = 0.49 Identities = 26/101 (25%), Positives = 41/101 (40%), Gaps = 25/101 (24%) Query: 254 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 313 LK++ ++E K + E + Y + +KW KNG E+ +K Q ++ K L Sbjct: 2975 LKDINAEE-----KDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQ---MRTKKLTHSLN 3026 Query: 314 INKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST 354 I D+ +Y T V ATST+T Sbjct: 3027 IRNVHFGDAADY-----------------TFVAGKATSTAT 3050 Score = 33.1 bits (74), Expect = 0.49 Identities = 26/96 (27%), Positives = 44/96 (45%), Gaps = 11/96 (11%) Query: 254 LKEMK----SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 309 +KE+K ++ GS + C S S+ W K+G+ + K + I K Sbjct: 11118 VKEIKDIILTESEFVGSSAIFECLVSP--STAITTWMKDGSNIRESPKHRFIADGKD--- 11172 Query: 310 SELRINKASLADSGEYMCKVISKLGNDSASANITIV 345 +L I L+D+GEY C + +LGN ++ +V Sbjct: 11173 RKLHIIDVQLSDAGEYTC--VLRLGNKEKTSTAKLV 11206 Score = 32.7 bits (73), Expect = 0.64 Identities = 15/66 (22%), Positives = 35/66 (53%), Gaps = 3/66 (4%) Query: 281 LRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASA 340 ++ W+K+ E+ +K ++ + L ++ S+ DSG+Y C+ + G+ S+S Sbjct: 7335 IKVLWYKDETEIQESSK---FRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSST 7391 Query: 341 NITIVE 346 ++ + E Sbjct: 7392 SLKVKE 7397 Score = 32.7 bits (73), Expect = 0.64 Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 5/76 (6%) Query: 254 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 313 ++ ++ Q V C+ S E +++ KW++NG E+ K K +K L Sbjct: 12826 VEHLEDQTVTEFDDAVFSCQLSREKANV--KWYRNGREIKEGKK---YKFEKDGSIHRLI 12880 Query: 314 INKASLADSGEYMCKV 329 I L D EY C V Sbjct: 12881 IKDCRLDDECEYACGV 12896 Score = 32.7 bits (73), Expect = 0.64 Identities = 16/61 (26%), Positives = 34/61 (55%), Gaps = 3/61 (4%) Query: 285 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 344 W K+G E+ ++ + ++ + L + K+ AD+G Y + +KLG+ +AS N+ + Sbjct: 14420 WHKDGKEVKASDR---LTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKV 14476 Query: 345 V 345 + Sbjct: 14477 I 14477 Score = 32.0 bits (71), Expect = 1.1 Identities = 23/83 (27%), Positives = 38/83 (45%), Gaps = 2/83 (2%) Query: 260 QESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASL 319 Q+ G +V C+ + W K+G L + + K+ G+ +L I+ Sbjct: 1091 QKLVEGGSVVFGCQVGGNPKPHVY-WKKSGVPLTTGYR-YKVSYNKQTGECKLVISMTFA 1148 Query: 320 ADSGEYMCKVISKLGNDSASANI 342 D+GEY V +K G SASA++ Sbjct: 1149 DDAGEYTIVVRNKHGETSASASL 1171 Score = 32.0 bits (71), Expect = 1.1 Identities = 23/94 (24%), Positives = 39/94 (41%), Gaps = 4/94 (4%) Query: 282 RFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASAN 341 + KWFK+ EL K I + S L + + +G+Y C V + +G+DS + Sbjct: 5360 KIKWFKDDVELVSGPK---CFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTM 5416 Query: 342 ITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGG 375 + + E S +VK + + C G Sbjct: 5417 LLVTEP-PKFVKKLEASKIVKAGDSSRLECKIAG 5449 Score = 31.6 bits (70), Expect = 1.4 Identities = 28/100 (28%), Positives = 44/100 (44%), Gaps = 10/100 (10%) Query: 247 RCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 306 R +P + +K Q+ ++V CE ++E + KWF+N + +K I +K Sbjct: 12641 RIVVPLKDTRVKEQQ-----EVVFNCEVNTE--GAKAKWFRNEEAIFDSSK---YIILQK 12690 Query: 307 PGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346 LRI A L D Y + + G + SA IVE Sbjct: 12691 DLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVE 12730 Score = 30.8 bits (68), Expect = 2.4 Identities = 20/93 (21%), Positives = 40/93 (43%), Gaps = 4/93 (4%) Query: 254 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 313 LK + G ++L T + + W K+G + K + +K L Sbjct: 5989 LKRLSDHSVEPGKSIILE-STYTGTLPISVTWKKDGFNITTSEKCNIVTTEKT---CILE 6044 Query: 314 INKASLADSGEYMCKVISKLGNDSASANITIVE 346 I ++ D+G+Y C++ ++ G D A ++ +E Sbjct: 6045 ILNSTKRDAGQYSCEIENEAGRDVCGALVSTLE 6077 Score = 30.8 bits (68), Expect = 2.4 Identities = 17/65 (26%), Positives = 32/65 (49%), Gaps = 3/65 (4%) Query: 282 RFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASAN 341 + KWFK EL ++ I + +EL + + +SG+Y C V + G+ S + + Sbjct: 6864 KVKWFKGSRELV---PGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTH 6920 Query: 342 ITIVE 346 + + E Sbjct: 6921 LFVKE 6925 Score = 30.8 bits (68), Expect = 2.4 Identities = 33/143 (23%), Positives = 60/143 (41%), Gaps = 8/143 (5%) Query: 208 FMEPDANSTSRAPAAF----RASFPPLETGRNLKKEVSRVLCKRC-ALPPRLKEMKSQES 262 F A S S +F +SF + L+ S++L +PP+++ + S S Sbjct: 33280 FASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDIS 33339 Query: 263 A-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLAD 321 G L + C + E + W G +++ + + + I+ + L I D Sbjct: 33340 IDEGKVLTVACAFTGEPTP-EVTWSCGGRKIHSQEQGR-FHIENTDDLTTLIIMDVQKQD 33397 Query: 322 SGEYMCKVISKLGNDSASANITI 344 G Y + ++ G+DSA+ NI I Sbjct: 33398 GGLYTLSLGNEFGSDSATVNIHI 33420 Score = 30.4 bits (67), Expect = 3.2 Identities = 43/193 (22%), Positives = 67/193 (34%), Gaps = 40/193 (20%) Query: 265 GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGE 324 G L C+ + L +W+K+G L K + K S LRI D+G Sbjct: 5718 GETCTLECKVAGT-PELSVEWYKDGKLLTSSQKHKFSFYNKI---SSLRILSVERQDAGT 5773 Query: 325 YMCKVISKLGNDSASANITIVESNATSTST---------TGTSHLVKCAE---------- 365 Y +V + +G S +A + + + + T G S +++C Sbjct: 5774 YTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAW 5833 Query: 366 -KEKTFCVNGGE---------CFM---VKDLSNPSRYLCKCPNEFTGDRCQNYVMA---- 408 EKT V+G + C + D S+ Y C N D C+ + Sbjct: 5834 FHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPP 5893 Query: 409 SFYSTSTPFLSLP 421 SF P LP Sbjct: 5894 SFVKEPEPLEVLP 5906 Score = 30.4 bits (67), Expect = 3.2 Identities = 17/68 (25%), Positives = 31/68 (45%), Gaps = 3/68 (4%) Query: 282 RFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASAN 341 + WF+ EL + ++ I + +EL + ++ SGEY C V + G S + Sbjct: 5923 KVNWFRGARELVKGDR---CNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTR 5979 Query: 342 ITIVESNA 349 + + E A Sbjct: 5980 LFVKEPAA 5987 Score = 29.6 bits (65), Expect = 5.4 Identities = 16/63 (25%), Positives = 31/63 (49%), Gaps = 2/63 (3%) Query: 284 KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 343 KW K + + N+ + I +K +++L I + DSG Y C ++ G ++ N+ Sbjct: 8486 KWTKG--KWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQ 8543 Query: 344 IVE 346 + E Sbjct: 8544 VDE 8546 Score = 29.6 bits (65), Expect = 5.4 Identities = 14/62 (22%), Positives = 31/62 (50%), Gaps = 1/62 (1%) Query: 285 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 344 W K+ + + P+ +KI + S+ + KA +D G+Y+ + G+ A A + + Sbjct: 18235 WTKDKDATDLTRSPR-VKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNV 18293 Query: 345 VE 346 ++ Sbjct: 18294 LD 18295 Score = 29.6 bits (65), Expect = 5.4 Identities = 21/84 (25%), Positives = 36/84 (42%), Gaps = 5/84 (5%) Query: 264 AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNI-KIQKKPGKSELRINKASLADS 322 AG +VL + + W K G ++ +P +I +I P S L I A+ D+ Sbjct: 20392 AGDTIVLNAISILGKPLPKSSWSKAGKDI----RPSDITQITSTPTSSMLTIKYATRKDA 20447 Query: 323 GEYMCKVISKLGNDSASANITIVE 346 GEY + G +T+++ Sbjct: 20448 GEYTITATNPFGTKVEHVKVTVLD 20471 Score = 29.3 bits (64), Expect = 7.0 Identities = 19/71 (26%), Positives = 33/71 (46%), Gaps = 5/71 (7%) Query: 255 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 314 K +K + + + CE S + +W K+ EL ++ IKIQK+ L I Sbjct: 3062 KHIKDIKVLEKKRAMFECEVSEP--DITVQWMKDDQELQITDR---IKIQKEKYVHRLLI 3116 Query: 315 NKASLADSGEY 325 ++D+G+Y Sbjct: 3117 PSTRMSDAGKY 3127 Score = 29.3 bits (64), Expect = 7.0 Identities = 16/60 (26%), Positives = 29/60 (48%), Gaps = 3/60 (5%) Query: 285 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 344 WFK +EL ++ + + +EL + + SGEY C V ++ G S + ++ I Sbjct: 7808 WFKGSSELVPGDR---CNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYI 7864 Score = 28.9 bits (63), Expect = 9.2 Identities = 16/66 (24%), Positives = 29/66 (43%), Gaps = 3/66 (4%) Query: 284 KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 343 +W +G L N+ +++ + G L A DSG C+ +K G D SA + Sbjct: 1737 EWLHDGKPLEAANR---LRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLI 1793 Query: 344 IVESNA 349 + + + Sbjct: 1794 VKDEKS 1799 Score = 28.9 bits (63), Expect = 9.2 Identities = 26/116 (22%), Positives = 47/116 (40%), Gaps = 5/116 (4%) Query: 233 GRNLKKEVSRVL-CKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNE 291 G +L +E V K LPP++ + AG KL + + KW K +E Sbjct: 18880 GVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPT-CKWKKGEDE 18938 Query: 292 LNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVES 347 + + ++ + K S L I + DSG Y + G D+ + ++++ Sbjct: 18939 VVTSS---HLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDA 18991 >gi|221316757 neurotrimin isoform 3 [Homo sapiens] Length = 355 Score = 52.8 bits (125), Expect = 6e-07 Identities = 37/122 (30%), Positives = 55/122 (45%), Gaps = 12/122 (9%) Query: 251 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310 PP + E K G K L+CE S+ S F+W+K+ L K +K++ +P S Sbjct: 222 PPYISEAKGTGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK--GVKVENRPFLS 278 Query: 311 ELRINKASLADSGEYMCKVISKLGNDSASANITIVES---------NATSTSTTGTSHLV 361 +L S D G Y C +KLG+ +AS + V++ A S + GTS Sbjct: 279 KLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFEVKTTALTPWKGPGAVSEVSNGTSRRA 338 Query: 362 KC 363 C Sbjct: 339 GC 340 >gi|66730481 neuregulin 3 [Homo sapiens] Length = 696 Score = 51.2 bits (121), Expect = 2e-06 Identities = 24/82 (29%), Positives = 44/82 (53%), Gaps = 7/82 (8%) Query: 331 SKLGNDSASANITIVESNA------TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLS 384 S + S+SA T E++ T+ ST + H C +K+ +C+N GECF+++ L+ Sbjct: 252 SSSSSSSSSATTTTPETSTSPKFHTTTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLT 311 Query: 385 NPSRYLCKCPNEFTGDRCQNYV 406 ++ C+C + G RC ++ Sbjct: 312 GSHKH-CRCKEGYQGVRCDQFL 332 >gi|45594240 limbic system-associated membrane protein [Homo sapiens] Length = 338 Score = 50.8 bits (120), Expect = 2e-06 Identities = 27/89 (30%), Positives = 46/89 (51%), Gaps = 4/89 (4%) Query: 251 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310 PP + E KS E+ G + L+CE S+ + F+W+++ +N N ++I+ G+S Sbjct: 218 PPTITESKSNEATTGRQASLKCEASA-VPAPDFEWYRDDTRINSAN---GLEIKSTEGQS 273 Query: 311 ELRINKASLADSGEYMCKVISKLGNDSAS 339 L + + G Y C +KLG +AS Sbjct: 274 SLTVTNVTEEHYGNYTCVAANKLGVTNAS 302 >gi|221316762 neurotrimin isoform 4 [Homo sapiens] Length = 316 Score = 50.4 bits (119), Expect = 3e-06 Identities = 30/89 (33%), Positives = 44/89 (49%), Gaps = 3/89 (3%) Query: 251 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310 PP + E K G K L+CE S+ S F+W+K+ L K +K++ +P S Sbjct: 222 PPYISEAKGTGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK--GVKVENRPFLS 278 Query: 311 ELRINKASLADSGEYMCKVISKLGNDSAS 339 +L S D G Y C +KLG+ +AS Sbjct: 279 KLIFFNVSEHDYGNYTCVASNKLGHTNAS 307 >gi|110349717 titin isoform novex-2 [Homo sapiens] Length = 27118 Score = 49.7 bits (117), Expect = 5e-06 Identities = 30/96 (31%), Positives = 48/96 (50%), Gaps = 4/96 (4%) Query: 249 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 308 A P ++++ E A G CE S ++RF+WFK G E+ +K I+ Sbjct: 4527 AAPVIKRKIEPLEVALGHLAKFTCEIQSA-PNVRFQWFKAGREIYESDK---CSIRSSKY 4582 Query: 309 KSELRINKASLADSGEYMCKVISKLGNDSASANITI 344 S L I + + D GEY CK ++ G+ S +A +T+ Sbjct: 4583 ISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 4618 Score = 46.6 bits (109), Expect = 4e-05 Identities = 28/95 (29%), Positives = 48/95 (50%), Gaps = 4/95 (4%) Query: 251 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310 P + + +SQ G ++ CE S E S +WFKN ++ + N+ I + Sbjct: 26829 PAFISQPRSQNINEGQNVLFTCEISGEPSP-EIEWFKNNLPISISS---NVSISRSRNVY 26884 Query: 311 ELRINKASLADSGEYMCKVISKLGNDSASANITIV 345 L I AS++DSG+Y K + G SA+A++ ++ Sbjct: 26885 SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVL 26919 Score = 44.7 bits (104), Expect = 2e-04 Identities = 27/78 (34%), Positives = 40/78 (51%), Gaps = 10/78 (12%) Query: 267 KLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM 326 ++ L+CE S + + KWFK+G E+ K I+ + L+I KA L D GEY+ Sbjct: 5374 EITLKCEVSKD---VPVKWFKDGEEIVPSPK---YSIKADGLRRILKIKKADLKDKGEYV 5427 Query: 327 CKVISKLGNDSASANITI 344 C G D AN+T+ Sbjct: 5428 C----DCGTDKTKANVTV 5441 Score = 39.3 bits (90), Expect = 0.007 Identities = 30/109 (27%), Positives = 47/109 (43%), Gaps = 8/109 (7%) Query: 245 CKRCALPPRLKEMKS-QESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 303 C +PP ++ ++ + K + R E + + KWFK+G E+ + K I Sbjct: 6060 CNLNVVPPHVEFLRPLTDLQVREKEMARFECELSRENAKVKWFKDGAEIKKGKK---YDI 6116 Query: 304 QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATST 352 K L INK L D EY C+V + S +T++E A T Sbjct: 6117 ISKGAVRILVINKCLLDDEAEYSCEVRTA----RTSGMLTVLEEEAVFT 6161 Score = 38.9 bits (89), Expect = 0.009 Identities = 28/120 (23%), Positives = 49/120 (40%), Gaps = 6/120 (5%) Query: 251 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310 P + +K+ G + L C S Y S W++ ++ + +I + G + Sbjct: 897 PTLVSGLKNVTVIEGESVTLECHISG-YPSPTVTWYREDYQIESSI---DFQITFQSGIA 952 Query: 311 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTF 370 L I +A DSG + C +++ G S S + + S TT + K +EK F Sbjct: 953 RLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE--KFTTEEKRF 1010 Score = 38.9 bits (89), Expect = 0.009 Identities = 25/79 (31%), Positives = 39/79 (49%), Gaps = 6/79 (7%) Query: 285 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT- 343 W K+G + + K K+ + G L I+K +DSG Y C V + G+ S+S +T Sbjct: 26580 WTKDGKAITQGGK---YKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 26636 Query: 344 --IVESNATSTSTTGTSHL 360 I ++ A ST TS + Sbjct: 26637 KAIKDTEAQKVSTQKTSEI 26655 Score = 37.7 bits (86), Expect = 0.020 Identities = 18/70 (25%), Positives = 31/70 (44%) Query: 285 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 344 W+K+G ++ + + + G +L IN + D EY +K G DS A +T+ Sbjct: 25418 WYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 25477 Query: 345 VESNATSTST 354 + ST Sbjct: 25478 TLHPPPTDST 25487 Score = 37.7 bits (86), Expect = 0.020 Identities = 46/197 (23%), Positives = 80/197 (40%), Gaps = 21/197 (10%) Query: 150 SAGEPGEEAPYLVKVHQVWAVKAGGLKKDSLLTVRLGTWGHPAFPSCGRLKEDSRYIFFM 209 S+ + +E Y V V G + + LT++ A S R+K + Sbjct: 26316 SSVQASDEGNYSVVVEN----SEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRV--K 26369 Query: 210 EPDANSTSRAPAAFRASFP----PLETGRNLKKEVSRVLCKRCALPPRLKEMKSQESAAG 265 P+A + + + S P P ET ++V + + PP++ + E+ Sbjct: 26370 SPEAVKSPKRVKSPEPSHPKAVSPTETKPTPTEKVQHL---PVSAPPKITQFLKAEA--- 26423 Query: 266 SKLVLRCETSSEYSSLRFK---WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADS 322 SK + + E S LR K W+K+G +L Q G EL+IN + +D Sbjct: 26424 SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH--YSADGTYELKINNLTESDQ 26481 Query: 323 GEYMCKVISKLGNDSAS 339 GEY+C++ + G + Sbjct: 26482 GEYVCEISGEGGTSKTN 26498 Score = 35.4 bits (80), Expect = 0.098 Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 2/43 (4%) Query: 255 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNK 297 K ++ Q G+ VL CE S E + + KWFKNG E+ + K Sbjct: 5984 KPLEDQTVEEGATAVLECEVSRE--NAKVKWFKNGTEILKSKK 6024 Score = 34.3 bits (77), Expect = 0.22 Identities = 26/104 (25%), Positives = 39/104 (37%), Gaps = 3/104 (2%) Query: 251 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310 P LKE+K A G + E + WFK +L I G Sbjct: 3767 PHFLKELKPIRCAQGLPAIFEYTVVGEPAPT-VTWFKENKQLC--TSVYYTIIHNPNGSG 3823 Query: 311 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST 354 +N DSG Y+CK + LG + +A + ++ + T T Sbjct: 3824 TFIVNDPQREDSGLYICKAENMLGESTCAAELLVLLEDTDMTDT 3867 Score = 33.9 bits (76), Expect = 0.29 Identities = 29/103 (28%), Positives = 43/103 (41%), Gaps = 7/103 (6%) Query: 255 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 314 K + Q A + V CE ++ S + +W ++G L N NI+ + K L I Sbjct: 2578 KPLTDQTVAESQEAVFECEVANPDS--KGEWLRDGKHLPLTN---NIRSESDGHKRRLII 2632 Query: 315 NKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGT 357 L D GEY KV + SA + V+ T + T T Sbjct: 2633 AATKLDDIGEYTYKVAT--SKTSAKLKVEAVKIKKTLKNLTVT 2673 Score = 33.5 bits (75), Expect = 0.37 Identities = 18/73 (24%), Positives = 33/73 (45%), Gaps = 3/73 (4%) Query: 272 CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 331 C+ + S + W+ +L K +I + G + L + + D G Y CKV++ Sbjct: 25284 CKIENYDQSTQVTWYFGVRQLENSEK---YEITYEDGVAILYVKDITKLDDGTYRCKVVN 25340 Query: 332 KLGNDSASANITI 344 G DS+ A + + Sbjct: 25341 DYGEDSSYAELFV 25353 Score = 33.5 bits (75), Expect = 0.37 Identities = 36/147 (24%), Positives = 57/147 (38%), Gaps = 15/147 (10%) Query: 210 EPDANSTSRAPAAFRASFPPLETGRNLKKEVS-RVLCKRCALPPRLKEMKSQESAAGSKL 268 E A++ ++ A S T R +K ++ R+L K PR + ESA S Sbjct: 26224 EHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTK-----PRSMTVYEGESARFS-- 26276 Query: 269 VLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCK 328 C+T E W + G L+ + Q + KS I+ +D G Y Sbjct: 26277 ---CDTDGEPVPT-VTWLRKGQVLSTSARHQ---VTTTKYKSTFEISSVQASDEGNYSVV 26329 Query: 329 VISKLGNDSASANITIVESNATSTSTT 355 V + G A +TI ++ T + T Sbjct: 26330 VENSEGKQEAEFTLTIQKARVTEKAVT 26356 Score = 33.1 bits (74), Expect = 0.49 Identities = 26/101 (25%), Positives = 41/101 (40%), Gaps = 25/101 (24%) Query: 254 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 313 LK++ ++E K + E + Y + +KW KNG E+ +K Q ++ K L Sbjct: 2929 LKDINAEE-----KDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQ---MRTKKLTHSLN 2980 Query: 314 INKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST 354 I D+ +Y T V ATST+T Sbjct: 2981 IRNVHFGDAADY-----------------TFVAGKATSTAT 3004 Score = 33.1 bits (74), Expect = 0.49 Identities = 26/96 (27%), Positives = 44/96 (45%), Gaps = 11/96 (11%) Query: 254 LKEMK----SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 309 +KE+K ++ GS + C S S+ W K+G+ + K + I K Sbjct: 4813 VKEIKDIILTESEFVGSSAIFECLVSP--STAITTWMKDGSNIRESPKHRFIADGKD--- 4867 Query: 310 SELRINKASLADSGEYMCKVISKLGNDSASANITIV 345 +L I L+D+GEY C + +LGN ++ +V Sbjct: 4868 RKLHIIDVQLSDAGEYTC--VLRLGNKEKTSTAKLV 4901 Score = 32.7 bits (73), Expect = 0.64 Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 5/76 (6%) Query: 254 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 313 ++ ++ Q V C+ S E +++ KW++NG E+ K K +K L Sbjct: 6521 VEHLEDQTVTEFDDAVFSCQLSREKANV--KWYRNGREIKEGKK---YKFEKDGSIHRLI 6575 Query: 314 INKASLADSGEYMCKV 329 I L D EY C V Sbjct: 6576 IKDCRLDDECEYACGV 6591 Score = 32.7 bits (73), Expect = 0.64 Identities = 16/61 (26%), Positives = 34/61 (55%), Gaps = 3/61 (4%) Query: 285 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 344 W K+G E+ ++ + ++ + L + K+ AD+G Y + +KLG+ +AS N+ + Sbjct: 8115 WHKDGKEVKASDR---LTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKV 8171 Query: 345 V 345 + Sbjct: 8172 I 8172 Score = 32.0 bits (71), Expect = 1.1 Identities = 23/83 (27%), Positives = 38/83 (45%), Gaps = 2/83 (2%) Query: 260 QESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASL 319 Q+ G +V C+ + W K+G L + + K+ G+ +L I+ Sbjct: 1045 QKLVEGGSVVFGCQVGGNPKPHVY-WKKSGVPLTTGYR-YKVSYNKQTGECKLVISMTFA 1102 Query: 320 ADSGEYMCKVISKLGNDSASANI 342 D+GEY V +K G SASA++ Sbjct: 1103 DDAGEYTIVVRNKHGETSASASL 1125 Score = 31.6 bits (70), Expect = 1.4 Identities = 28/100 (28%), Positives = 44/100 (44%), Gaps = 10/100 (10%) Query: 247 RCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 306 R +P + +K Q+ ++V CE ++E + KWF+N + +K I +K Sbjct: 6336 RIVVPLKDTRVKEQQ-----EVVFNCEVNTE--GAKAKWFRNEEAIFDSSK---YIILQK 6385 Query: 307 PGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346 LRI A L D Y + + G + SA IVE Sbjct: 6386 DLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVE 6425 Score = 30.8 bits (68), Expect = 2.4 Identities = 33/143 (23%), Positives = 60/143 (41%), Gaps = 8/143 (5%) Query: 208 FMEPDANSTSRAPAAF----RASFPPLETGRNLKKEVSRVLCKRC-ALPPRLKEMKSQES 262 F A S S +F +SF + L+ S++L +PP+++ + S S Sbjct: 26975 FASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDIS 27034 Query: 263 A-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLAD 321 G L + C + E + W G +++ + + + I+ + L I D Sbjct: 27035 IDEGKVLTVACAFTGEPTP-EVTWSCGGRKIHSQEQGR-FHIENTDDLTTLIIMDVQKQD 27092 Query: 322 SGEYMCKVISKLGNDSASANITI 344 G Y + ++ G+DSA+ NI I Sbjct: 27093 GGLYTLSLGNEFGSDSATVNIHI 27115 Score = 29.6 bits (65), Expect = 5.4 Identities = 14/62 (22%), Positives = 31/62 (50%), Gaps = 1/62 (1%) Query: 285 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 344 W K+ + + P+ +KI + S+ + KA +D G+Y+ + G+ A A + + Sbjct: 11930 WTKDKDATDLTRSPR-VKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNV 11988 Query: 345 VE 346 ++ Sbjct: 11989 LD 11990 Score = 29.6 bits (65), Expect = 5.4 Identities = 21/84 (25%), Positives = 36/84 (42%), Gaps = 5/84 (5%) Query: 264 AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNI-KIQKKPGKSELRINKASLADS 322 AG +VL + + W K G ++ +P +I +I P S L I A+ D+ Sbjct: 14087 AGDTIVLNAISILGKPLPKSSWSKAGKDI----RPSDITQITSTPTSSMLTIKYATRKDA 14142 Query: 323 GEYMCKVISKLGNDSASANITIVE 346 GEY + G +T+++ Sbjct: 14143 GEYTITATNPFGTKVEHVKVTVLD 14166 Score = 29.3 bits (64), Expect = 7.0 Identities = 19/71 (26%), Positives = 33/71 (46%), Gaps = 5/71 (7%) Query: 255 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 314 K +K + + + CE S + +W K+ EL ++ IKIQK+ L I Sbjct: 3016 KHIKDIKVLEKKRAMFECEVSEP--DITVQWMKDDQELQITDR---IKIQKEKYVHRLLI 3070 Query: 315 NKASLADSGEY 325 ++D+G+Y Sbjct: 3071 PSTRMSDAGKY 3081 Score = 28.9 bits (63), Expect = 9.2 Identities = 16/66 (24%), Positives = 29/66 (43%), Gaps = 3/66 (4%) Query: 284 KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 343 +W +G L N+ +++ + G L A DSG C+ +K G D SA + Sbjct: 1691 EWLHDGKPLEAANR---LRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLI 1747 Query: 344 IVESNA 349 + + + Sbjct: 1748 VKDEKS 1753 Score = 28.9 bits (63), Expect = 9.2 Identities = 14/39 (35%), Positives = 24/39 (61%), Gaps = 1/39 (2%) Query: 312 LRINKASLAD-SGEYMCKVISKLGNDSASANITIVESNA 349 L I+K + D GEY+C+ ++ G + SA +T+V+ A Sbjct: 4490 LVIDKVNTEDHQGEYVCEALNDSGKTATSAKLTVVKRAA 4528 Score = 28.9 bits (63), Expect = 9.2 Identities = 26/116 (22%), Positives = 47/116 (40%), Gaps = 5/116 (4%) Query: 233 GRNLKKEVSRVL-CKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNE 291 G +L +E V K LPP++ + AG KL + + KW K +E Sbjct: 12575 GVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPT-CKWKKGEDE 12633 Query: 292 LNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVES 347 + + ++ + K S L I + DSG Y + G D+ + ++++ Sbjct: 12634 VVTSS---HLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDA 12686 >gi|110349713 titin isoform novex-1 [Homo sapiens] Length = 27051 Score = 49.7 bits (117), Expect = 5e-06 Identities = 30/96 (31%), Positives = 48/96 (50%), Gaps = 4/96 (4%) Query: 249 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 308 A P ++++ E A G CE S ++RF+WFK G E+ +K I+ Sbjct: 4460 AAPVIKRKIEPLEVALGHLAKFTCEIQSA-PNVRFQWFKAGREIYESDK---CSIRSSKY 4515 Query: 309 KSELRINKASLADSGEYMCKVISKLGNDSASANITI 344 S L I + + D GEY CK ++ G+ S +A +T+ Sbjct: 4516 ISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 4551 Score = 46.6 bits (109), Expect = 4e-05 Identities = 28/95 (29%), Positives = 48/95 (50%), Gaps = 4/95 (4%) Query: 251 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310 P + + +SQ G ++ CE S E S +WFKN ++ + N+ I + Sbjct: 26762 PAFISQPRSQNINEGQNVLFTCEISGEPSP-EIEWFKNNLPISISS---NVSISRSRNVY 26817 Query: 311 ELRINKASLADSGEYMCKVISKLGNDSASANITIV 345 L I AS++DSG+Y K + G SA+A++ ++ Sbjct: 26818 SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVL 26852 Score = 44.7 bits (104), Expect = 2e-04 Identities = 27/78 (34%), Positives = 40/78 (51%), Gaps = 10/78 (12%) Query: 267 KLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM 326 ++ L+CE S + + KWFK+G E+ K I+ + L+I KA L D GEY+ Sbjct: 5307 EITLKCEVSKD---VPVKWFKDGEEIVPSPK---YSIKADGLRRILKIKKADLKDKGEYV 5360 Query: 327 CKVISKLGNDSASANITI 344 C G D AN+T+ Sbjct: 5361 C----DCGTDKTKANVTV 5374 Score = 39.3 bits (90), Expect = 0.007 Identities = 30/109 (27%), Positives = 47/109 (43%), Gaps = 8/109 (7%) Query: 245 CKRCALPPRLKEMKS-QESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 303 C +PP ++ ++ + K + R E + + KWFK+G E+ + K I Sbjct: 5993 CNLNVVPPHVEFLRPLTDLQVREKEMARFECELSRENAKVKWFKDGAEIKKGKK---YDI 6049 Query: 304 QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATST 352 K L INK L D EY C+V + S +T++E A T Sbjct: 6050 ISKGAVRILVINKCLLDDEAEYSCEVRTA----RTSGMLTVLEEEAVFT 6094 Score = 38.9 bits (89), Expect = 0.009 Identities = 28/120 (23%), Positives = 49/120 (40%), Gaps = 6/120 (5%) Query: 251 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310 P + +K+ G + L C S Y S W++ ++ + +I + G + Sbjct: 897 PTLVSGLKNVTVIEGESVTLECHISG-YPSPTVTWYREDYQIESSI---DFQITFQSGIA 952 Query: 311 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTF 370 L I +A DSG + C +++ G S S + + S TT + K +EK F Sbjct: 953 RLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE--KFTTEEKRF 1010 Score = 38.9 bits (89), Expect = 0.009 Identities = 25/79 (31%), Positives = 39/79 (49%), Gaps = 6/79 (7%) Query: 285 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT- 343 W K+G + + K K+ + G L I+K +DSG Y C V + G+ S+S +T Sbjct: 26513 WTKDGKAITQGGK---YKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 26569 Query: 344 --IVESNATSTSTTGTSHL 360 I ++ A ST TS + Sbjct: 26570 KAIKDTEAQKVSTQKTSEI 26588 Score = 37.7 bits (86), Expect = 0.020 Identities = 18/70 (25%), Positives = 31/70 (44%) Query: 285 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 344 W+K+G ++ + + + G +L IN + D EY +K G DS A +T+ Sbjct: 25351 WYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 25410 Query: 345 VESNATSTST 354 + ST Sbjct: 25411 TLHPPPTDST 25420 Score = 37.7 bits (86), Expect = 0.020 Identities = 46/197 (23%), Positives = 80/197 (40%), Gaps = 21/197 (10%) Query: 150 SAGEPGEEAPYLVKVHQVWAVKAGGLKKDSLLTVRLGTWGHPAFPSCGRLKEDSRYIFFM 209 S+ + +E Y V V G + + LT++ A S R+K + Sbjct: 26249 SSVQASDEGNYSVVVEN----SEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRV--K 26302 Query: 210 EPDANSTSRAPAAFRASFP----PLETGRNLKKEVSRVLCKRCALPPRLKEMKSQESAAG 265 P+A + + + S P P ET ++V + + PP++ + E+ Sbjct: 26303 SPEAVKSPKRVKSPEPSHPKAVSPTETKPTPTEKVQHL---PVSAPPKITQFLKAEA--- 26356 Query: 266 SKLVLRCETSSEYSSLRFK---WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADS 322 SK + + E S LR K W+K+G +L Q G EL+IN + +D Sbjct: 26357 SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH--YSADGTYELKINNLTESDQ 26414 Query: 323 GEYMCKVISKLGNDSAS 339 GEY+C++ + G + Sbjct: 26415 GEYVCEISGEGGTSKTN 26431 Score = 35.4 bits (80), Expect = 0.098 Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 2/43 (4%) Query: 255 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNK 297 K ++ Q G+ VL CE S E + + KWFKNG E+ + K Sbjct: 5917 KPLEDQTVEEGATAVLECEVSRE--NAKVKWFKNGTEILKSKK 5957 Score = 34.3 bits (77), Expect = 0.22 Identities = 26/104 (25%), Positives = 39/104 (37%), Gaps = 3/104 (2%) Query: 251 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 310 P LKE+K A G + E + WFK +L I G Sbjct: 3700 PHFLKELKPIRCAQGLPAIFEYTVVGEPAPT-VTWFKENKQLC--TSVYYTIIHNPNGSG 3756 Query: 311 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST 354 +N DSG Y+CK + LG + +A + ++ + T T Sbjct: 3757 TFIVNDPQREDSGLYICKAENMLGESTCAAELLVLLEDTDMTDT 3800 Score = 33.9 bits (76), Expect = 0.29 Identities = 29/103 (28%), Positives = 43/103 (41%), Gaps = 7/103 (6%) Query: 255 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 314 K + Q A + V CE ++ S + +W ++G L N NI+ + K L I Sbjct: 2578 KPLTDQTVAESQEAVFECEVANPDS--KGEWLRDGKHLPLTN---NIRSESDGHKRRLII 2632 Query: 315 NKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGT 357 L D GEY KV + SA + V+ T + T T Sbjct: 2633 AATKLDDIGEYTYKVAT--SKTSAKLKVEAVKIKKTLKNLTVT 2673 Score = 33.5 bits (75), Expect = 0.37 Identities = 18/73 (24%), Positives = 33/73 (45%), Gaps = 3/73 (4%) Query: 272 CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 331 C+ + S + W+ +L K +I + G + L + + D G Y CKV++ Sbjct: 25217 CKIENYDQSTQVTWYFGVRQLENSEK---YEITYEDGVAILYVKDITKLDDGTYRCKVVN 25273 Query: 332 KLGNDSASANITI 344 G DS+ A + + Sbjct: 25274 DYGEDSSYAELFV 25286 Score = 33.5 bits (75), Expect = 0.37 Identities = 36/147 (24%), Positives = 57/147 (38%), Gaps = 15/147 (10%) Query: 210 EPDANSTSRAPAAFRASFPPLETGRNLKKEVS-RVLCKRCALPPRLKEMKSQESAAGSKL 268 E A++ ++ A S T R +K ++ R+L K PR + ESA S Sbjct: 26157 EHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTK-----PRSMTVYEGESARFS-- 26209 Query: 269 VLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCK 328 C+T E W + G L+ + Q + KS I+ +D G Y Sbjct: 26210 ---CDTDGEPVPT-VTWLRKGQVLSTSARHQ---VTTTKYKSTFEISSVQASDEGNYSVV 26262 Query: 329 VISKLGNDSASANITIVESNATSTSTT 355 V + G A +TI ++ T + T Sbjct: 26263 VENSEGKQEAEFTLTIQKARVTEKAVT 26289 Score = 33.1 bits (74), Expect = 0.49 Identities = 26/101 (25%), Positives = 41/101 (40%), Gaps = 25/101 (24%) Query: 254 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 313 LK++ ++E K + E + Y + +KW KNG E+ +K Q ++ K L Sbjct: 2929 LKDINAEE-----KDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQ---MRTKKLTHSLN 2980 Query: 314 INKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST 354 I D+ +Y T V ATST+T Sbjct: 2981 IRNVHFGDAADY-----------------TFVAGKATSTAT 3004 Score = 33.1 bits (74), Expect = 0.49 Identities = 26/96 (27%), Positives = 44/96 (45%), Gaps = 11/96 (11%) Query: 254 LKEMK----SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 309 +KE+K ++ GS + C S S+ W K+G+ + K + I K Sbjct: 4746 VKEIKDIILTESEFVGSSAIFECLVSP--STAITTWMKDGSNIRESPKHRFIADGKD--- 4800 Query: 310 SELRINKASLADSGEYMCKVISKLGNDSASANITIV 345 +L I L+D+GEY C + +LGN ++ +V Sbjct: 4801 RKLHIIDVQLSDAGEYTC--VLRLGNKEKTSTAKLV 4834 Score = 32.7 bits (73), Expect = 0.64 Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 5/76 (6%) Query: 254 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 313 ++ ++ Q V C+ S E +++ KW++NG E+ K K +K L Sbjct: 6454 VEHLEDQTVTEFDDAVFSCQLSREKANV--KWYRNGREIKEGKK---YKFEKDGSIHRLI 6508 Query: 314 INKASLADSGEYMCKV 329 I L D EY C V Sbjct: 6509 IKDCRLDDECEYACGV 6524 Score = 32.7 bits (73), Expect = 0.64 Identities = 16/61 (26%), Positives = 34/61 (55%), Gaps = 3/61 (4%) Query: 285 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 344 W K+G E+ ++ + ++ + L + K+ AD+G Y + +KLG+ +AS N+ + Sbjct: 8048 WHKDGKEVKASDR---LTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKV 8104 Query: 345 V 345 + Sbjct: 8105 I 8105 Score = 32.0 bits (71), Expect = 1.1 Identities = 23/83 (27%), Positives = 38/83 (45%), Gaps = 2/83 (2%) Query: 260 QESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASL 319 Q+ G +V C+ + W K+G L + + K+ G+ +L I+ Sbjct: 1045 QKLVEGGSVVFGCQVGGNPKPHVY-WKKSGVPLTTGYR-YKVSYNKQTGECKLVISMTFA 1102 Query: 320 ADSGEYMCKVISKLGNDSASANI 342 D+GEY V +K G SASA++ Sbjct: 1103 DDAGEYTIVVRNKHGETSASASL 1125 Score = 31.6 bits (70), Expect = 1.4 Identities = 28/100 (28%), Positives = 44/100 (44%), Gaps = 10/100 (10%) Query: 247 RCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 306 R +P + +K Q+ ++V CE ++E + KWF+N + +K I +K Sbjct: 6269 RIVVPLKDTRVKEQQ-----EVVFNCEVNTE--GAKAKWFRNEEAIFDSSK---YIILQK 6318 Query: 307 PGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 346 LRI A L D Y + + G + SA IVE Sbjct: 6319 DLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVE 6358 Score = 30.8 bits (68), Expect = 2.4 Identities = 33/143 (23%), Positives = 60/143 (41%), Gaps = 8/143 (5%) Query: 208 FMEPDANSTSRAPAAF----RASFPPLETGRNLKKEVSRVLCKRC-ALPPRLKEMKSQES 262 F A S S +F +SF + L+ S++L +PP+++ + S S Sbjct: 26908 FASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDIS 26967 Query: 263 A-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLAD 321 G L + C + E + W G +++ + + + I+ + L I D Sbjct: 26968 IDEGKVLTVACAFTGEPTP-EVTWSCGGRKIHSQEQGR-FHIENTDDLTTLIIMDVQKQD 27025 Query: 322 SGEYMCKVISKLGNDSASANITI 344 G Y + ++ G+DSA+ NI I Sbjct: 27026 GGLYTLSLGNEFGSDSATVNIHI 27048 Score = 29.6 bits (65), Expect = 5.4 Identities = 14/62 (22%), Positives = 31/62 (50%), Gaps = 1/62 (1%) Query: 285 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 344 W K+ + + P+ +KI + S+ + KA +D G+Y+ + G+ A A + + Sbjct: 11863 WTKDKDATDLTRSPR-VKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNV 11921 Query: 345 VE 346 ++ Sbjct: 11922 LD 11923 Score = 29.6 bits (65), Expect = 5.4 Identities = 21/84 (25%), Positives = 36/84 (42%), Gaps = 5/84 (5%) Query: 264 AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNI-KIQKKPGKSELRINKASLADS 322 AG +VL + + W K G ++ +P +I +I P S L I A+ D+ Sbjct: 14020 AGDTIVLNAISILGKPLPKSSWSKAGKDI----RPSDITQITSTPTSSMLTIKYATRKDA 14075 Query: 323 GEYMCKVISKLGNDSASANITIVE 346 GEY + G +T+++ Sbjct: 14076 GEYTITATNPFGTKVEHVKVTVLD 14099 Score = 29.3 bits (64), Expect = 7.0 Identities = 19/71 (26%), Positives = 33/71 (46%), Gaps = 5/71 (7%) Query: 255 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 314 K +K + + + CE S + +W K+ EL ++ IKIQK+ L I Sbjct: 3016 KHIKDIKVLEKKRAMFECEVSEP--DITVQWMKDDQELQITDR---IKIQKEKYVHRLLI 3070 Query: 315 NKASLADSGEY 325 ++D+G+Y Sbjct: 3071 PSTRMSDAGKY 3081 Score = 28.9 bits (63), Expect = 9.2 Identities = 16/66 (24%), Positives = 29/66 (43%), Gaps = 3/66 (4%) Query: 284 KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 343 +W +G L N+ +++ + G L A DSG C+ +K G D SA + Sbjct: 1691 EWLHDGKPLEAANR---LRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLI 1747 Query: 344 IVESNA 349 + + + Sbjct: 1748 VKDEKS 1753 Score = 28.9 bits (63), Expect = 9.2 Identities = 14/39 (35%), Positives = 24/39 (61%), Gaps = 1/39 (2%) Query: 312 LRINKASLAD-SGEYMCKVISKLGNDSASANITIVESNA 349 L I+K + D GEY+C+ ++ G + SA +T+V+ A Sbjct: 4423 LVIDKVNTEDHQGEYVCEALNDSGKTATSAKLTVVKRAA 4461 Score = 28.9 bits (63), Expect = 9.2 Identities = 26/116 (22%), Positives = 47/116 (40%), Gaps = 5/116 (4%) Query: 233 GRNLKKEVSRVL-CKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNE 291 G +L +E V K LPP++ + AG KL + + KW K +E Sbjct: 12508 GVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPT-CKWKKGEDE 12566 Query: 292 LNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVES 347 + + ++ + K S L I + DSG Y + G D+ + ++++ Sbjct: 12567 VVTSS---HLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDA 12619 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.314 0.130 0.392 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,950,587 Number of Sequences: 37866 Number of extensions: 1006718 Number of successful extensions: 7768 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 153 Number of HSP's successfully gapped in prelim test: 610 Number of HSP's that attempted gapping in prelim test: 6018 Number of HSP's gapped (non-prelim): 2226 length of query: 422 length of database: 18,247,518 effective HSP length: 105 effective length of query: 317 effective length of database: 14,271,588 effective search space: 4524093396 effective search space used: 4524093396 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (22.0 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.