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Search of human proteins with 23397678
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23397678 signal transducer and activator of transcription 6
[Homo sapiens]
(847 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23397678 signal transducer and activator of transcription 6 [... 1711 0.0
gi|21618344 signal transducer and activator of transcription 5B ... 454 e-127
gi|21618342 signal transducer and activator of transcription 5A ... 453 e-127
gi|4507255 signal transducer and activator of transcription 4 [H... 207 3e-53
gi|47458820 signal transducer and activator of transcription 3 i... 191 2e-48
gi|21618338 signal transducer and activator of transcription 3 i... 191 2e-48
gi|21618340 signal transducer and activator of transcription 3 i... 191 2e-48
gi|6274552 signal transducer and activator of transcription 1 is... 177 3e-44
gi|21536301 signal transducer and activator of transcription 1 i... 177 5e-44
gi|4885615 signal transducer and activator of transcription 2 [H... 175 2e-43
gi|122937496 WAS/WASL interacting protein family, member 3 [Homo... 40 0.007
gi|21264565 AT rich interactive domain 1A isoform a [Homo sapiens] 40 0.009
gi|21264575 AT rich interactive domain 1A isoform b [Homo sapiens] 40 0.009
gi|169168458 PREDICTED: hypothetical protein [Homo sapiens] 37 0.059
gi|119943125 G protein-coupled receptor 64 isoform 3 [Homo sapiens] 37 0.059
gi|119943116 G protein-coupled receptor 64 isoform 2 [Homo sapiens] 37 0.059
gi|119943120 G protein-coupled receptor 64 isoform 1 [Homo sapiens] 37 0.059
gi|119943129 G protein-coupled receptor 64 isoform 4 [Homo sapiens] 37 0.059
gi|56549668 AT rich interactive domain 2 (ARID, RFX-like) [Homo ... 37 0.059
gi|148612809 WNK lysine deficient protein kinase 1 [Homo sapiens] 37 0.10
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 37 0.10
gi|119393899 GLI-Kruppel family member GLI3 [Homo sapiens] 36 0.13
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 36 0.13
gi|146134388 YLP motif containing 1 [Homo sapiens] 36 0.13
gi|50345997 E1A binding protein p300 [Homo sapiens] 36 0.17
gi|5174457 kinetochore associated 2 [Homo sapiens] 36 0.17
gi|157412247 RUN and SH3 domain containing 1 isoform b [Homo sap... 35 0.22
gi|157412245 RUN and SH3 domain containing 1 isoform a [Homo sap... 35 0.22
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 35 0.29
gi|15812226 transcriptional regulating factor 1 [Homo sapiens] 35 0.29
>gi|23397678 signal transducer and activator of transcription 6
[Homo sapiens]
Length = 847
Score = 1711 bits (4430), Expect = 0.0
Identities = 847/847 (100%), Positives = 847/847 (100%)
Query: 1 MSLWGLVSKMPPEKVQRLYVDFPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASALLSDT 60
MSLWGLVSKMPPEKVQRLYVDFPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASALLSDT
Sbjct: 1 MSLWGLVSKMPPEKVQRLYVDFPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASALLSDT 60
Query: 61 VQHLQASVGEQGEGSTILQHISTLESIYQRDPLKLVATFRQILQGEKKAVMEQFRHLPMP 120
VQHLQASVGEQGEGSTILQHISTLESIYQRDPLKLVATFRQILQGEKKAVMEQFRHLPMP
Sbjct: 61 VQHLQASVGEQGEGSTILQHISTLESIYQRDPLKLVATFRQILQGEKKAVMEQFRHLPMP 120
Query: 121 FHWKQEELKFKTGLRRLQHRVGEIHLLREALQKGAEAGQVSLHSLIETPANGTGPSEALA 180
FHWKQEELKFKTGLRRLQHRVGEIHLLREALQKGAEAGQVSLHSLIETPANGTGPSEALA
Sbjct: 121 FHWKQEELKFKTGLRRLQHRVGEIHLLREALQKGAEAGQVSLHSLIETPANGTGPSEALA 180
Query: 181 MLLQETTGELEAAKALVLKRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQ 240
MLLQETTGELEAAKALVLKRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQ
Sbjct: 181 MLLQETTGELEAAKALVLKRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQ 240
Query: 241 EVGAAGGELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLR 300
EVGAAGGELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLR
Sbjct: 241 EVGAAGGELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLR 300
Query: 301 FLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALF 360
FLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALF
Sbjct: 301 FLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALF 360
Query: 361 KNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDN 420
KNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDN
Sbjct: 361 KNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDN 420
Query: 421 NAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQK 480
NAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQK
Sbjct: 421 NAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQK 480
Query: 481 IFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIG 540
IFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIG
Sbjct: 481 IFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIG 540
Query: 541 FISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIR 600
FISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIR
Sbjct: 541 FISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIR 600
Query: 601 SLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPE 660
SLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPE
Sbjct: 601 SLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPE 660
Query: 661 LQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSIPPYQGLSPEESVNVLSAFQE 720
LQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSIPPYQGLSPEESVNVLSAFQE
Sbjct: 661 LQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSIPPYQGLSPEESVNVLSAFQE 720
Query: 721 PHLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAF 780
PHLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAF
Sbjct: 721 PHLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAF 780
Query: 781 PQGTWIGEDIFPPLLPPTEQDLTKLLLEGQGESGGGSLGAQPLLQPSHYGQSGISMSHMD 840
PQGTWIGEDIFPPLLPPTEQDLTKLLLEGQGESGGGSLGAQPLLQPSHYGQSGISMSHMD
Sbjct: 781 PQGTWIGEDIFPPLLPPTEQDLTKLLLEGQGESGGGSLGAQPLLQPSHYGQSGISMSHMD 840
Query: 841 LRANPSW 847
LRANPSW
Sbjct: 841 LRANPSW 847
>gi|21618344 signal transducer and activator of transcription 5B
[Homo sapiens]
Length = 787
Score = 454 bits (1169), Expect = e-127
Identities = 305/790 (38%), Positives = 434/790 (54%), Gaps = 89/790 (11%)
Query: 1 MSLWGLVSKMPPE---KVQRLYVD-FPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASAL 56
M++W ++ E ++Q LY FP +RH L W+ESQ W+ + + A+ L
Sbjct: 1 MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQL 60
Query: 57 LSDTVQHLQASVGEQ-GEGSTILQ----HIST-LESIYQRDPLKLVATFRQILQGEKKAV 110
L VQ LQ Q GE +L+ H +T L++ Y R P++LV R IL E++ V
Sbjct: 61 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV 120
Query: 111 MEQ------------------------FRHLPMPFHWKQEELK------------FKTGL 134
E F L + + ELK ++ L
Sbjct: 121 REANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL 180
Query: 135 RRLQHRVGEIHLL----REALQKGAEAGQVSLHSLIETPANGTGPSEA-LAMLLQETTGE 189
R +Q + G + L R + + + QVSL + ++ A LA Q+T
Sbjct: 181 R-IQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQL 239
Query: 190 LEAAKALVLKRIQI-WKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAG-- 246
L + ++L I WKR+QQLAGNG P E SL LQ CE L +I Q +Q++ A
Sbjct: 240 LRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHL 299
Query: 247 -------GELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGL 299
G +E + A + + +++ LVTS F++EKQPPQVLKTQTKF A VR L+G
Sbjct: 300 CQQLPIPGPVE-EMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGG 358
Query: 300 RFLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSAL 359
+ L PP V+A +++E+QA+ L + + +GEI+NN +E SA
Sbjct: 359 K-LNVHMNPPQVKATIISEQQAKSLL--KNENTRNDYSGEILNNCCVMEYHQATGTLSAH 415
Query: 360 FKNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQD 419
F+N+ LK+IKR +R+G ESVTEEK +LF + F++G +L Q++ LSLP+VVIVHG+QD
Sbjct: 416 FRNMSLKRIKRSDRRGAESVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQD 475
Query: 420 NNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQ 479
NNA AT+LWDNAF+E RVPF V ++V W ++CE LN+KF AEV +NRGL E+ +FLAQ
Sbjct: 476 NNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQ 535
Query: 480 KIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLII 539
K+FN++S +E + SVSWSQFN+E L GR +TFWQWFDGV+++ K+ L+ +W+D I+
Sbjct: 536 KLFNNSSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAIL 595
Query: 540 GFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSI 599
GF++KQ LL+N+PDGTFLLRFSDSEIGGITIA Q+ N+ PF+ +D SI
Sbjct: 596 GFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQE--RMFWNLMPFTTRDFSI 653
Query: 600 RSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKP----EQMGKDGRGYVPATIKMTVERDQP 655
RSL DR+ DL L ++P +PKDE + +Y P K GYV IK V
Sbjct: 654 RSLADRLGDLNYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVV----- 708
Query: 656 LPTPELQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQ----VYPPHSHSIPPYQG-LSPEE 710
PE + S D G + M P + PQ +YP + S+ G E+
Sbjct: 709 ---PEF----VNASADAGGGSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLED 761
Query: 711 SVNVLSAFQE 720
+++V +E
Sbjct: 762 TMDVARRVEE 771
>gi|21618342 signal transducer and activator of transcription 5A
[Homo sapiens]
Length = 794
Score = 453 bits (1166), Expect = e-127
Identities = 301/786 (38%), Positives = 436/786 (55%), Gaps = 86/786 (10%)
Query: 1 MSLWGLVSKMPPEKVQRLYVDFPQH----LRHLLGDWLESQPWEFLVGSDAFCCNLASAL 56
M+ W ++ + ++++ V + QH +RH L W+ESQPW+ + + A+ L
Sbjct: 1 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL 60
Query: 57 LSDTVQHLQASVGEQ-GEGSTILQ----HIST-LESIYQRDPLKLVATFRQILQGEKKAV 110
L VQ LQ Q GE +L+ H +T L+ Y R PL+LV R IL E++ V
Sbjct: 61 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV 120
Query: 111 MEQ------------------------FRHLPMPFHWKQEELK------------FKTGL 134
E F L + + ELK ++ L
Sbjct: 121 REANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL 180
Query: 135 RRLQHRVGEIHLL----REALQKGAEAGQVSLHSLIETPANGTGPSEA-LAMLLQETTGE 189
R +Q + ++ L R + + + QVSL + ++ A LA Q+T
Sbjct: 181 R-IQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQL 239
Query: 190 LEAAKALVLKRIQI-WKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAG-- 246
L + ++L I WKR+QQLAGNG P E SL LQ CE L +I Q +Q++ A
Sbjct: 240 LRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHL 299
Query: 247 -------GELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGL 299
G +E + A + + +++ LVTS F++EKQPPQVLKTQTKF A VR L+G
Sbjct: 300 CQQLPIPGPVE-EMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGG 358
Query: 300 RFLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSAL 359
+ L PP V+A +++E+QA+ L + E +GEI+NN +E SA
Sbjct: 359 K-LNVHMNPPQVKATIISEQQAKSLL--KNENTRNECSGEILNNCCVMEYHQATGTLSAH 415
Query: 360 FKNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQD 419
F+N+ LK+IKR +R+G ESVTEEK VLF + F++G +L Q++ LSLP+VVIVHG+QD
Sbjct: 416 FRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQD 475
Query: 420 NNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQ 479
+NA AT+LWDNAF+E RVPF V ++V W ++CE LN+KF AEV +NRGL E+ +FLAQ
Sbjct: 476 HNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQ 535
Query: 480 KIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLII 539
K+FN++S +E + SVSWSQFN+E L G +TFWQWFDGV+++ K+ + +W+D I+
Sbjct: 536 KLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAIL 595
Query: 540 GFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSI 599
GF++KQ LL+N+PDGTFLLRFSDSEIGGITIA + + + N++PF+ +D SI
Sbjct: 596 GFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERN--LWNLKPFTTRDFSI 653
Query: 600 RSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTP 659
RSL DR+ DL+ L ++P +PKDE F +Y P + K GYV IK V P
Sbjct: 654 RSLADRLGDLSYLIYVFPDRPKDEVFSKYYTP-VLAKAVDGYVKPQIKQVV--------P 704
Query: 660 ELQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQ----VYPPHSHSIPPYQG-LSPEESVNV 714
E + S D G + + M P + PQ +YP + + G +E+++V
Sbjct: 705 EF----VNASADAGGSSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDV 760
Query: 715 LSAFQE 720
+E
Sbjct: 761 ARHVEE 766
>gi|4507255 signal transducer and activator of transcription 4 [Homo
sapiens]
Length = 748
Score = 207 bits (528), Expect = 3e-53
Identities = 203/756 (26%), Positives = 328/756 (43%), Gaps = 120/756 (15%)
Query: 1 MSLWGLVSKMPP---EKVQRLYVD-FPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASAL 56
MS W V ++ E+V + Y D FP +RHLL W+E+Q WE ++ +A+ L
Sbjct: 1 MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNET----MATIL 56
Query: 57 LSDTVQHLQASVGEQGEGSTIL------QHISTLESIYQRDPLKLVATFRQILQGEKKAV 110
L + + L +G + +L + L+ + +P+ + L+ E++ +
Sbjct: 57 LQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRIL 116
Query: 111 MEQFRHLPMPFHWKQEELKFKTGLRRLQHRVGEIH----------LLREALQKGAEAGQV 160
+ P + R ++H+V I E LQ +
Sbjct: 117 AAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYK 176
Query: 161 SLHSLIETPANGTGPSEALAMLLQETTGELEAAK-------------------ALVLKRI 201
++ ++ ++ N ++ + + LQE L+ + ++++ +
Sbjct: 177 TIQTMDQSDKNSAMVNQEV-LTLQEMLNSLDFKRKEALSKMTQIIHETDLLMNTMLIEEL 235
Query: 202 QIWKRQQQLAGNGAPFEESLAPLQE----RCESLVDIYSQL-----QQEVGAAGGELEPK 252
Q WKR+QQ+A G P L LQ ESL + QL Q G+ P
Sbjct: 236 QDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPM 295
Query: 253 TRASLTGRLDEVLRTLVTSCFLVEKQP--------PQVLKTQTKFQAGVRFLLGLRFLGA 304
R + R+ ++ L + F+VE+QP P VLKT +F +R L+ L L
Sbjct: 296 QRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNY 355
Query: 305 PAKPPLVRADMVTEKQARELS----VPQGPGAGAESTGEIINNTVPLENSIPGNCCSALF 360
K V+A + +K LS V G A S E N ++ +E F
Sbjct: 356 QVK---VKASI--DKNVSTLSNRRFVLCGTNVKAMSIEESSNGSLSVE-----------F 399
Query: 361 KNLLLKKIKRCE----RKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHG 416
++L K++K +G VTEE ++ F L L I L+ SLP+V+I +
Sbjct: 400 RHLQPKEMKSSAGGKGNEGCHMVTEELHSITFETQICLYG--LTIDLETSSLPVVMISNV 457
Query: 417 NQDNNAKATILWDNAFSEMDRVPFVVAERVP---WEKMCETLNLKFMAEVGTNRGLLPEH 473
+Q NA A+I+W N S D V P ++ E ++ +F + VG RGL +
Sbjct: 458 SQLPNAWASIIWYNV-STNDSQNLVFFNNPPPATLSQLLEVMSWQFSSYVG--RGLNSDQ 514
Query: 474 FLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYW 533
LA+K+ +S S ++W++F KE L G+ FTFW W + +LDL K+ + W
Sbjct: 515 LHMLAEKLTVQSSYS-----DGHLTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLW 569
Query: 534 SDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFS 593
D ++GF+SK+ LL ++ GTFLLRFS+S +GGIT V + G + +++P++
Sbjct: 570 IDGYVMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDHSESGEVRFHSVEPYN 629
Query: 594 AKDLSIRSLGDRIRDLA----------QLKNLYPKKPKDEAFRSHY--------KPEQMG 635
LS D +RD LK LYP PKD+AF HY +P + G
Sbjct: 630 KGRLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTERG 689
Query: 636 KDGRGYVPATI--KMTVERDQPLPTPELQMPTMVPS 669
+GYVP+ T+ D P + M PS
Sbjct: 690 --DKGYVPSVFIPISTIRSDSTEPHSPSDLLPMSPS 723
>gi|47458820 signal transducer and activator of transcription 3
isoform 3 [Homo sapiens]
Length = 722
Score = 191 bits (486), Expect = 2e-48
Identities = 195/714 (27%), Positives = 326/714 (45%), Gaps = 106/714 (14%)
Query: 1 MSLWGLVSKMPP---EKVQRLYVD-FPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASAL 56
M+ W + ++ E++ +LY D FP LR L W+ESQ W + ++ + L
Sbjct: 1 MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL 60
Query: 57 LSDTVQHLQASVGEQGEGSTILQHI-----STLESIYQRDPLKLVATFRQILQGEKKAVM 111
L + Q + E + + QH L+S Y P+++ + L E + +
Sbjct: 61 LGEIDQQYSRFLQES---NVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQ 117
Query: 112 E---------QFRHLPMPFHWKQEELKFKTGLRRLQHRVGEIHL---LREALQKGAEAGQ 159
Q H P +++ + L+ ++ RV ++ + E LQ +
Sbjct: 118 TAATAAQQGGQANH-PTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNY 176
Query: 160 VSLHSLIETP-ANGTGPS-----------------EALAMLLQETTGELEAA----KALV 197
+L S + NG S + ++ E G L A K L
Sbjct: 177 KTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLT 236
Query: 198 LKRIQIWKRQQQLAGNGAP----------FEESLAPLQERCESLVDIYSQLQQEVGAAGG 247
+ + WKR+QQ+A G P + SLA Q + + +LQQ+V G
Sbjct: 237 DEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGD 296
Query: 248 ELEPKTRASLTGRLDEVLRTLVTSCFLVEKQP--------PQVLKTQTKFQAGVRFLLGL 299
+ + R L R+ E+ R L+ S F+VE+QP P V+KT +F VR L+
Sbjct: 297 PIV-QHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKF 355
Query: 300 RFLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNT--VPLENSIPGNCCS 357
L K + +K + +++ +G + + NT + +E S G+ S
Sbjct: 356 PELNYQLK-----IKVCIDKDSGDVAALRG----SRKFNILGTNTKVMNMEESNNGSL-S 405
Query: 358 ALFKNLLLKKIKRCERKGTES------VTEEKCAVLFSASFTLGPGKLPIQLQALSLPLV 411
A FK+L L++ +RC G + VTEE + F + L I L+ SLP+V
Sbjct: 406 AEFKHLTLRE-QRCGNGGRANCDASLIVTEELHLITFETE--VYHQGLKIDLETHSLPVV 462
Query: 412 VIVHGNQDNNAKATILWDNAFSEMDR-VPFVVAERV-PWEKMCETLNLKFMAEVGTNRGL 469
VI + Q NA A+ILW N + + V F + W+++ E L+ +F + T RGL
Sbjct: 463 VISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSST--TKRGL 520
Query: 470 LPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCL 529
E LA+K+ + ++W++F KE + G+GF+FW W D ++DL K+ +
Sbjct: 521 SIEQLTTLAEKLLGPGV----NYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYI 576
Query: 530 RSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSD-SEIGGITIAHVIRGQDGSPQIEN 588
+ W++ I+GFISK+ ++L +P GTFLLRFS+ S+ GG+T V + G QI++
Sbjct: 577 LALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQS 636
Query: 589 IQPFSAKDLSIRS-----LGDRIRD-----LAQLKNLYPKKPKDEAFRSHYKPE 632
++P++ + L+ S +G +I D ++ L LYP PK+EAF + +PE
Sbjct: 637 VEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPE 690
>gi|21618338 signal transducer and activator of transcription 3
isoform 2 [Homo sapiens]
Length = 769
Score = 191 bits (486), Expect = 2e-48
Identities = 195/714 (27%), Positives = 326/714 (45%), Gaps = 106/714 (14%)
Query: 1 MSLWGLVSKMPP---EKVQRLYVD-FPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASAL 56
M+ W + ++ E++ +LY D FP LR L W+ESQ W + ++ + L
Sbjct: 1 MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL 60
Query: 57 LSDTVQHLQASVGEQGEGSTILQHI-----STLESIYQRDPLKLVATFRQILQGEKKAVM 111
L + Q + E + + QH L+S Y P+++ + L E + +
Sbjct: 61 LGEIDQQYSRFLQES---NVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQ 117
Query: 112 E---------QFRHLPMPFHWKQEELKFKTGLRRLQHRVGEIHL---LREALQKGAEAGQ 159
Q H P +++ + L+ ++ RV ++ + E LQ +
Sbjct: 118 TAATAAQQGGQANH-PTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNY 176
Query: 160 VSLHSLIETP-ANGTGPS-----------------EALAMLLQETTGELEAA----KALV 197
+L S + NG S + ++ E G L A K L
Sbjct: 177 KTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLT 236
Query: 198 LKRIQIWKRQQQLAGNGAP----------FEESLAPLQERCESLVDIYSQLQQEVGAAGG 247
+ + WKR+QQ+A G P + SLA Q + + +LQQ+V G
Sbjct: 237 DEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGD 296
Query: 248 ELEPKTRASLTGRLDEVLRTLVTSCFLVEKQP--------PQVLKTQTKFQAGVRFLLGL 299
+ + R L R+ E+ R L+ S F+VE+QP P V+KT +F VR L+
Sbjct: 297 PIV-QHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKF 355
Query: 300 RFLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNT--VPLENSIPGNCCS 357
L K + +K + +++ +G + + NT + +E S G+ S
Sbjct: 356 PELNYQLK-----IKVCIDKDSGDVAALRG----SRKFNILGTNTKVMNMEESNNGSL-S 405
Query: 358 ALFKNLLLKKIKRCERKGTES------VTEEKCAVLFSASFTLGPGKLPIQLQALSLPLV 411
A FK+L L++ +RC G + VTEE + F + L I L+ SLP+V
Sbjct: 406 AEFKHLTLRE-QRCGNGGRANCDASLIVTEELHLITFETE--VYHQGLKIDLETHSLPVV 462
Query: 412 VIVHGNQDNNAKATILWDNAFSEMDR-VPFVVAERV-PWEKMCETLNLKFMAEVGTNRGL 469
VI + Q NA A+ILW N + + V F + W+++ E L+ +F + T RGL
Sbjct: 463 VISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSST--TKRGL 520
Query: 470 LPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCL 529
E LA+K+ + ++W++F KE + G+GF+FW W D ++DL K+ +
Sbjct: 521 SIEQLTTLAEKLLGPGV----NYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYI 576
Query: 530 RSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSD-SEIGGITIAHVIRGQDGSPQIEN 588
+ W++ I+GFISK+ ++L +P GTFLLRFS+ S+ GG+T V + G QI++
Sbjct: 577 LALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQS 636
Query: 589 IQPFSAKDLSIRS-----LGDRIRD-----LAQLKNLYPKKPKDEAFRSHYKPE 632
++P++ + L+ S +G +I D ++ L LYP PK+EAF + +PE
Sbjct: 637 VEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPE 690
>gi|21618340 signal transducer and activator of transcription 3
isoform 1 [Homo sapiens]
Length = 770
Score = 191 bits (486), Expect = 2e-48
Identities = 195/714 (27%), Positives = 326/714 (45%), Gaps = 106/714 (14%)
Query: 1 MSLWGLVSKMPP---EKVQRLYVD-FPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASAL 56
M+ W + ++ E++ +LY D FP LR L W+ESQ W + ++ + L
Sbjct: 1 MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL 60
Query: 57 LSDTVQHLQASVGEQGEGSTILQHI-----STLESIYQRDPLKLVATFRQILQGEKKAVM 111
L + Q + E + + QH L+S Y P+++ + L E + +
Sbjct: 61 LGEIDQQYSRFLQES---NVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQ 117
Query: 112 E---------QFRHLPMPFHWKQEELKFKTGLRRLQHRVGEIHL---LREALQKGAEAGQ 159
Q H P +++ + L+ ++ RV ++ + E LQ +
Sbjct: 118 TAATAAQQGGQANH-PTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNY 176
Query: 160 VSLHSLIETP-ANGTGPS-----------------EALAMLLQETTGELEAA----KALV 197
+L S + NG S + ++ E G L A K L
Sbjct: 177 KTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLT 236
Query: 198 LKRIQIWKRQQQLAGNGAP----------FEESLAPLQERCESLVDIYSQLQQEVGAAGG 247
+ + WKR+QQ+A G P + SLA Q + + +LQQ+V G
Sbjct: 237 DEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGD 296
Query: 248 ELEPKTRASLTGRLDEVLRTLVTSCFLVEKQP--------PQVLKTQTKFQAGVRFLLGL 299
+ + R L R+ E+ R L+ S F+VE+QP P V+KT +F VR L+
Sbjct: 297 PIV-QHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKF 355
Query: 300 RFLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNT--VPLENSIPGNCCS 357
L K + +K + +++ +G + + NT + +E S G+ S
Sbjct: 356 PELNYQLK-----IKVCIDKDSGDVAALRG----SRKFNILGTNTKVMNMEESNNGSL-S 405
Query: 358 ALFKNLLLKKIKRCERKGTES------VTEEKCAVLFSASFTLGPGKLPIQLQALSLPLV 411
A FK+L L++ +RC G + VTEE + F + L I L+ SLP+V
Sbjct: 406 AEFKHLTLRE-QRCGNGGRANCDASLIVTEELHLITFETE--VYHQGLKIDLETHSLPVV 462
Query: 412 VIVHGNQDNNAKATILWDNAFSEMDR-VPFVVAERV-PWEKMCETLNLKFMAEVGTNRGL 469
VI + Q NA A+ILW N + + V F + W+++ E L+ +F + T RGL
Sbjct: 463 VISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSST--TKRGL 520
Query: 470 LPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCL 529
E LA+K+ + ++W++F KE + G+GF+FW W D ++DL K+ +
Sbjct: 521 SIEQLTTLAEKLLGPGV----NYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYI 576
Query: 530 RSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSD-SEIGGITIAHVIRGQDGSPQIEN 588
+ W++ I+GFISK+ ++L +P GTFLLRFS+ S+ GG+T V + G QI++
Sbjct: 577 LALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQS 636
Query: 589 IQPFSAKDLSIRS-----LGDRIRD-----LAQLKNLYPKKPKDEAFRSHYKPE 632
++P++ + L+ S +G +I D ++ L LYP PK+EAF + +PE
Sbjct: 637 VEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPE 690
>gi|6274552 signal transducer and activator of transcription 1
isoform alpha [Homo sapiens]
Length = 750
Score = 177 bits (450), Expect = 3e-44
Identities = 203/750 (27%), Positives = 321/750 (42%), Gaps = 124/750 (16%)
Query: 13 EKVQRLYVD-FPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASALLSDTV-QHLQASVGE 70
E+V +LY D FP +R L WLE Q WE +F LLS Q+ + S+
Sbjct: 16 EQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSL-- 73
Query: 71 QGEGSTILQHI-----STLESIYQRDPLKLVATFRQILQGEKKAVMEQFR---------- 115
E + +LQH L+ +Q DP+++ L+ E+K + R
Sbjct: 74 --ENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQ 131
Query: 116 --------------------------HLPMPFHWKQEELKFKTGLRRLQHRVGEIHLLRE 149
H Q+E FK + LQ+R E + + +
Sbjct: 132 STVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKC--KTLQNREHETNGVAK 189
Query: 150 ALQKGAEAGQVSLHSLIETPANGTGPSEALAMLLQETTGELEAAKALVLKRIQIWKRQQQ 209
+ QK + ++ +++ E + +++ AL+ + WKR+QQ
Sbjct: 190 SDQKQEQLLLKKMYLMLDNKRK-----EVVHKIIELLNVTELTQNALINDELVEWKRRQQ 244
Query: 210 LAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELEPK----------TRASLTG 259
A G P L LQ + + Q++Q++ ELE K + L
Sbjct: 245 SACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLE-ELEQKYTYEHDPITKNKQVLWD 303
Query: 260 RLDEVLRTLVTSCFLVEKQP--------PQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLV 311
R + + L+ S F+VE+QP P VLKT +F +R L+ L+ L K ++
Sbjct: 304 RTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVL 363
Query: 312 RADMVTEKQA----RELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALFKNLLLKK 367
V E+ R+ ++ G + +++N +E S G+ +A F++L LK+
Sbjct: 364 FDKDVNERNTVKGFRKFNI-----LGTHT--KVMN----MEESTNGSL-AAEFRHLQLKE 411
Query: 368 IKRCERKGTES---VTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDNNAKA 424
K + E VTEE ++ F PG L I L+ SLP+VVI + +Q + A
Sbjct: 412 QKNAGTRTNEGPLIVTEELHSLSFETQLCQ-PG-LVIDLETTSLPVVVISNVSQLPSGWA 469
Query: 425 TILWDNAFSEMDRVP--FVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQKIF 482
+ILW N R F+ W ++ E L+ +F + T RGL + L +K+
Sbjct: 470 SILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSV--TKRGLNVDQLNMLGEKLL 527
Query: 483 NDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFI 542
N A + W++F KE + + F FW W + +L+L K+ L W+D I+GFI
Sbjct: 528 GPN-----ASPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFI 582
Query: 543 SKQYVTSLLLNEPDGTFLLRFSD-SEIGGITIAHVIRGQD-GSPQIENIQPFSAKDLSIR 600
SK+ +LL ++ GTFLLRFS+ S G IT V R Q+ G P ++P++ K+LS
Sbjct: 583 SKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAV 642
Query: 601 SLGDRIRDLA----------QLKNLYPKKPKDEAFRSHYK-----PEQM---GKDGRGYV 642
+ D IR+ LK LYP KD AF +Y PE M G G GY+
Sbjct: 643 TFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYI 702
Query: 643 PA-TIKMTVERDQPLPTPELQMPTMVPSYD 671
I ++ L T + +P +D
Sbjct: 703 KTELISVSEVHPSRLQTTDNLLPMSPEEFD 732
>gi|21536301 signal transducer and activator of transcription 1
isoform beta [Homo sapiens]
Length = 712
Score = 177 bits (448), Expect = 5e-44
Identities = 198/720 (27%), Positives = 311/720 (43%), Gaps = 123/720 (17%)
Query: 13 EKVQRLYVD-FPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASALLSDTV-QHLQASVGE 70
E+V +LY D FP +R L WLE Q WE +F LLS Q+ + S+
Sbjct: 16 EQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSL-- 73
Query: 71 QGEGSTILQHI-----STLESIYQRDPLKLVATFRQILQGEKKAVMEQFR---------- 115
E + +LQH L+ +Q DP+++ L+ E+K + R
Sbjct: 74 --ENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQ 131
Query: 116 --------------------------HLPMPFHWKQEELKFKTGLRRLQHRVGEIHLLRE 149
H Q+E FK + LQ+R E + + +
Sbjct: 132 STVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKC--KTLQNREHETNGVAK 189
Query: 150 ALQKGAEAGQVSLHSLIETPANGTGPSEALAMLLQETTGELEAAKALVLKRIQIWKRQQQ 209
+ QK + ++ +++ E + +++ AL+ + WKR+QQ
Sbjct: 190 SDQKQEQLLLKKMYLMLDNKRK-----EVVHKIIELLNVTELTQNALINDELVEWKRRQQ 244
Query: 210 LAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELEPK----------TRASLTG 259
A G P L LQ + + Q++Q++ ELE K + L
Sbjct: 245 SACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLE-ELEQKYTYEHDPITKNKQVLWD 303
Query: 260 RLDEVLRTLVTSCFLVEKQP--------PQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLV 311
R + + L+ S F+VE+QP P VLKT +F +R L+ L+ L K ++
Sbjct: 304 RTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVL 363
Query: 312 RADMVTEKQA----RELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALFKNLLLKK 367
V E+ R+ ++ G + +++N +E S G+ +A F++L LK+
Sbjct: 364 FDKDVNERNTVKGFRKFNI-----LGTHT--KVMN----MEESTNGSL-AAEFRHLQLKE 411
Query: 368 IKRCERKGTES---VTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDNNAKA 424
K + E VTEE ++ F PG L I L+ SLP+VVI + +Q + A
Sbjct: 412 QKNAGTRTNEGPLIVTEELHSLSFETQLCQ-PG-LVIDLETTSLPVVVISNVSQLPSGWA 469
Query: 425 TILWDNAFSEMDRVP--FVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQKIF 482
+ILW N R F+ W ++ E L+ +F + T RGL + L +K+
Sbjct: 470 SILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSV--TKRGLNVDQLNMLGEKLL 527
Query: 483 NDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFI 542
N A + W++F KE + + F FW W + +L+L K+ L W+D I+GFI
Sbjct: 528 GPN-----ASPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFI 582
Query: 543 SKQYVTSLLLNEPDGTFLLRFSD-SEIGGITIAHVIRGQD-GSPQIENIQPFSAKDLSIR 600
SK+ +LL ++ GTFLLRFS+ S G IT V R Q+ G P ++P++ K+LS
Sbjct: 583 SKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAV 642
Query: 601 SLGDRIRDLA----------QLKNLYPKKPKDEAFRSHYK-----PEQM---GKDGRGYV 642
+ D IR+ LK LYP KD AF +Y PE M G G GY+
Sbjct: 643 TFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYI 702
>gi|4885615 signal transducer and activator of transcription 2 [Homo
sapiens]
Length = 851
Score = 175 bits (443), Expect = 2e-43
Identities = 230/902 (25%), Positives = 372/902 (41%), Gaps = 165/902 (18%)
Query: 1 MSLWGLVSKMPP---EKVQRLYVD--FPQHLRHLLGDWLESQPW-EFLVGSDAFCCNLAS 54
M+ W ++ + +++ +LY P +R L W+E Q W E +GSD + A+
Sbjct: 1 MAQWEMLQNLDSPFQDQLHQLYSHSLLPVDIRQYLAVWIEDQNWQEAALGSDD---SKAT 57
Query: 55 ALLSDTVQHLQASVGE--QGEGSTILQHISTLESI------YQRDPLKLVATFRQILQGE 106
L + L G Q S +LQH L + +DP +L +L E
Sbjct: 58 MLFFHFLDQLNYECGRCSQDPESLLLQH--NLRKFCRDIQPFSQDPTQLAEMIFNLLLEE 115
Query: 107 KKAVMEQFRHLPMPFHWKQEELKFKTGLRRLQH----RVGEIHLLREALQKGAEA---GQ 159
K+ +++ R +Q E +T + QH R+ ++ + E L K Q
Sbjct: 116 KRILIQAQRA-----QLEQGEPVLETPVESQQHEIESRILDLRAMMEKLVKSISQLKDQQ 170
Query: 160 VSLHSLIETPANGTGPS-----EALAMLLQETTGELE--------AAKALV--------- 197
+ A G PS +LQET EL+ A+KAL+
Sbjct: 171 DVFCFRYKIQAKGKTPSLDPHQTKEQKILQETLNELDKRRKEVLDASKALLGRLTTLIEL 230
Query: 198 -LKRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGG-------EL 249
L +++ WK QQQ A AP + L L+ + + L+Q + G +
Sbjct: 231 LLPKLEEWKAQQQKACIRAPIDHGLEQLETWFTAGAKLLFHLRQLLKELKGLSCLVSYQD 290
Query: 250 EPKTRAS--LTGRLDEVLRTLVTSCFLVEKQP--------PQVLKTQTKFQAGVRFLLGL 299
+P T+ ++ E+L+ L+ F+VE QP P +LKT +KF R L
Sbjct: 291 DPLTKGVDLRNAQVTELLQRLLHRAFVVETQPCMPQTPHRPLILKTGSKFTVRTRLL--- 347
Query: 300 RFLGAPAKPPLVRADMVTEKQARELSVPQGPGA--GAESTGEIINNT---VPLENSIPGN 354
VR E E+S+ + P G + +N P + G
Sbjct: 348 -----------VRLQEGNESLTVEVSIDRNPPQLQGFRKFNILTSNQKTLTPEKGQSQGL 396
Query: 355 CCSALFKNLLLKKIK---RCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLV 411
+ L+ ++ + KG VTEE + F+ +T L +L+ +LP+V
Sbjct: 397 IWDFGYLTLVEQRSGGSGKGSNKGPLGVTEELHIISFTVKYTYQG--LKQELKTDTLPVV 454
Query: 412 VIVHGNQDNNAKATILWDNAFSE--MDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGL 469
+I + NQ + A A++LW N S ++ F + PW + L+ +F + VG RGL
Sbjct: 455 IISNMNQLSIAWASVLWFNLLSPNLQNQQFFSNPPKAPWSLLGPALSWQFSSYVG--RGL 512
Query: 470 LPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCL 529
+ L K+F N + + +SW+ F K FW W D +L+L L
Sbjct: 513 NSDQLSMLRNKLFGQNCRTEDPL----LSWADFTKRESPPGKLPFWTWLDKILELVHDHL 568
Query: 530 RSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENI 589
+ W+D I+GF+S+ LL GTFLLRFS+S GGIT + V D I ++
Sbjct: 569 KDLWNDGRIMGFVSRSQERRLLKKTMSGTFLLRFSESSEGGITCSWVEHQDDDKVLIYSV 628
Query: 590 QPFSAKDLSIRSLGDRIRDLA----------QLKNLYPKKPKDEAFRSHYKPEQMGKDGR 639
QP++ + L L + IR L+ LYP+ P+DEAF +Y+ + ++ R
Sbjct: 629 QPYTKEVLQSLPLTEIIRHYQLLTEENIPENPLRFLYPRIPRDEAFGCYYQEKVNLQERR 688
Query: 640 GY-----VPATIKMTVERDQPL---PTPELQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQ 691
Y + + + E QPL P PEL+ + +LG+ P+ +S+ L P +
Sbjct: 689 KYLKHRLIVVSNRQVDELQQPLELKPEPELESLEL----ELGLVPEPELSLDLEPLLKAG 744
Query: 692 VYPPHSHSIPPYQGLSPEESVNVLSAFQEPHLQMPPSLGQMSL--------PFDQPHPQG 743
+ L PE +VL + EP ++ P+L +S P QP P+
Sbjct: 745 L------------DLGPELE-SVLESTLEPVIE--PTLCMVSQTVPEPDQGPVSQPVPEP 789
Query: 744 LLPCQPQ----------------EHAVSSPDPLLCSDVTMVEDSCLSQPVTAFPQGTWIG 787
LPC + E + + DPLL T V++ +S+P + G +
Sbjct: 790 DLPCDLRHLNTEPMEIFRNCVKIEEIMPNGDPLLAGQNT-VDEVYVSRPSHFYTDGPLMP 848
Query: 788 ED 789
D
Sbjct: 849 SD 850
>gi|122937496 WAS/WASL interacting protein family, member 3 [Homo
sapiens]
Length = 483
Score = 40.4 bits (93), Expect = 0.007
Identities = 51/174 (29%), Positives = 63/174 (36%), Gaps = 25/174 (14%)
Query: 655 PLPTPELQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSIPP--YQGLSPEESV 712
P P P PT P + D ++ QL P +P + PP +PP Y GL E +
Sbjct: 223 PPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPI-PPPLPLLPPCGYPGLKAEPAS 281
Query: 713 NVLSAFQEPHLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSS---PDPLLCSDVTMVE 769
A QEP PP P+ P+ LP P SS P PL
Sbjct: 282 PAQDA-QEPPAPPPP-----LPPYASCSPRASLPAPPLPGVNSSSETPPPL--------- 326
Query: 770 DSCLSQPVTAFPQGTWIGEDIFP-PLLPPTEQDLTKLLLEGQGESGGGSLGAQP 822
S A PQ G P P PP Q + G+ +GGG L P
Sbjct: 327 -PPKSPSFQAPPQKA--GAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPP 377
>gi|21264565 AT rich interactive domain 1A isoform a [Homo sapiens]
Length = 2285
Score = 40.0 bits (92), Expect = 0.009
Identities = 54/248 (21%), Positives = 83/248 (33%), Gaps = 49/248 (19%)
Query: 631 PEQMGKDGRGY--------VPATIKMTVERDQPLPTPELQMPTMVPSYDLGMAPDSSMSM 682
P + G GY P MT++ L +P Y G S
Sbjct: 407 PPSGPQQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGGLSYTQQIPPY--GQQGPSGYGQ 464
Query: 683 QLGPDMVPQVYPPHSHSIPPYQGLSPEESVNVLSAFQEPHLQMPPSLGQMSLPFDQ---- 738
Q Q P PPY P ++ + ++Q+ PP L P+ Q
Sbjct: 465 QGQTPYYNQQSPHPQQQQPPYSQQPPSQTPHAQPSYQQQPQSQPPQLQSSQPPYSQQPSQ 524
Query: 739 -PHPQGLLP-----CQPQEHAVSSP--------------DPLLCSDVTMVEDSCLSQPVT 778
PH Q P Q+H S P P + T+ + + QP +
Sbjct: 525 PPHQQSPAPYPSQQSTTQQHPQSQPPYSQPQAQSPYQQQQPQQPAPSTLSQQAAYPQPQS 584
Query: 779 AFPQGTWIGEDIFPPLLPPTEQDLTKLLLEGQGESGGGSLGAQPLLQPSHYGQSGISMSH 838
Q T + FPP Q+L++ +S G + P + S GQ +++S
Sbjct: 585 QQSQQTAYSQQRFPP-----PQELSQ-------DSFGSQASSAPSMTSSKGGQEDMNLS- 631
Query: 839 MDLRANPS 846
L++ PS
Sbjct: 632 --LQSRPS 637
Score = 30.8 bits (68), Expect = 5.5
Identities = 24/72 (33%), Positives = 32/72 (44%), Gaps = 4/72 (5%)
Query: 653 DQPLPTPELQMPTMVPSYDLG--MAPDS-SMSMQLGPDMVPQVYPPHSHS-IPPYQGLSP 708
D P++Q P+ S + P S S SM G D+ P HS IPP G+S
Sbjct: 1122 DSKKSQPKIQPPSPAGSGSMQGPQTPQSTSSSMAEGGDLKPPTPASTPHSQIPPLPGMSR 1181
Query: 709 EESVNVLSAFQE 720
SV + AF +
Sbjct: 1182 SNSVGIQDAFND 1193
>gi|21264575 AT rich interactive domain 1A isoform b [Homo sapiens]
Length = 2068
Score = 40.0 bits (92), Expect = 0.009
Identities = 54/248 (21%), Positives = 83/248 (33%), Gaps = 49/248 (19%)
Query: 631 PEQMGKDGRGY--------VPATIKMTVERDQPLPTPELQMPTMVPSYDLGMAPDSSMSM 682
P + G GY P MT++ L +P Y G S
Sbjct: 407 PPSGPQQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGGLSYTQQIPPY--GQQGPSGYGQ 464
Query: 683 QLGPDMVPQVYPPHSHSIPPYQGLSPEESVNVLSAFQEPHLQMPPSLGQMSLPFDQ---- 738
Q Q P PPY P ++ + ++Q+ PP L P+ Q
Sbjct: 465 QGQTPYYNQQSPHPQQQQPPYSQQPPSQTPHAQPSYQQQPQSQPPQLQSSQPPYSQQPSQ 524
Query: 739 -PHPQGLLP-----CQPQEHAVSSP--------------DPLLCSDVTMVEDSCLSQPVT 778
PH Q P Q+H S P P + T+ + + QP +
Sbjct: 525 PPHQQSPAPYPSQQSTTQQHPQSQPPYSQPQAQSPYQQQQPQQPAPSTLSQQAAYPQPQS 584
Query: 779 AFPQGTWIGEDIFPPLLPPTEQDLTKLLLEGQGESGGGSLGAQPLLQPSHYGQSGISMSH 838
Q T + FPP Q+L++ +S G + P + S GQ +++S
Sbjct: 585 QQSQQTAYSQQRFPP-----PQELSQ-------DSFGSQASSAPSMTSSKGGQEDMNLS- 631
Query: 839 MDLRANPS 846
L++ PS
Sbjct: 632 --LQSRPS 637
Score = 30.8 bits (68), Expect = 5.5
Identities = 24/72 (33%), Positives = 32/72 (44%), Gaps = 4/72 (5%)
Query: 653 DQPLPTPELQMPTMVPSYDLG--MAPDS-SMSMQLGPDMVPQVYPPHSHS-IPPYQGLSP 708
D P++Q P+ S + P S S SM G D+ P HS IPP G+S
Sbjct: 1122 DSKKSQPKIQPPSPAGSGSMQGPQTPQSTSSSMAEGGDLKPPTPASTPHSQIPPLPGMSR 1181
Query: 709 EESVNVLSAFQE 720
SV + AF +
Sbjct: 1182 SNSVGIQDAFND 1193
>gi|169168458 PREDICTED: hypothetical protein [Homo sapiens]
Length = 353
Score = 37.4 bits (85), Expect = 0.059
Identities = 36/131 (27%), Positives = 49/131 (37%), Gaps = 20/131 (15%)
Query: 657 PTPELQMPTMVPSYDLGM--APDSSMSMQLGPDMVPQVYPPHSHSIPPYQGLSPE----- 709
P P MP+ VP + +P S S Q + P +P H PP LSP
Sbjct: 168 PAPLASMPSSVPKTSIESLGSPSSLSSSQASEPLCPLKHPSHR---PPASTLSPNPTSST 224
Query: 710 ESVNVLSAFQEPHLQMPPSLGQMSLPFDQPHPQ--------GLLPCQPQEHAVSSPDPLL 761
ES+ LS+ Q P L + P +PH + G + A S D ++
Sbjct: 225 ESLGYLSSLSSS--QPPEPLRPLKHPSHKPHGRSPPRRRNPGWVSWSDSMQADSETDAII 282
Query: 762 CSDVTMVEDSC 772
C E SC
Sbjct: 283 CPMCKAPERSC 293
>gi|119943125 G protein-coupled receptor 64 isoform 3 [Homo sapiens]
Length = 995
Score = 37.4 bits (85), Expect = 0.059
Identities = 25/72 (34%), Positives = 35/72 (48%), Gaps = 9/72 (12%)
Query: 690 PQVYPPHSHSIPP----YQGLSPEESVNVLSAFQEPHLQMPPSLGQMSLPFDQPHPQGLL 745
P Y P +H++P Q LSP+ S + S+ P + MPP +S P Q H G
Sbjct: 260 PPDYSPVTHNVPSPIGEIQPLSPQPSAPIASS---PAIDMPPQSETISSPMPQTHVSGTP 316
Query: 746 PCQPQEHAVSSP 757
P P + + SSP
Sbjct: 317 P--PVKASFSSP 326
>gi|119943116 G protein-coupled receptor 64 isoform 2 [Homo sapiens]
Length = 1003
Score = 37.4 bits (85), Expect = 0.059
Identities = 25/72 (34%), Positives = 35/72 (48%), Gaps = 9/72 (12%)
Query: 690 PQVYPPHSHSIPP----YQGLSPEESVNVLSAFQEPHLQMPPSLGQMSLPFDQPHPQGLL 745
P Y P +H++P Q LSP+ S + S+ P + MPP +S P Q H G
Sbjct: 268 PPDYSPVTHNVPSPIGEIQPLSPQPSAPIASS---PAIDMPPQSETISSPMPQTHVSGTP 324
Query: 746 PCQPQEHAVSSP 757
P P + + SSP
Sbjct: 325 P--PVKASFSSP 334
>gi|119943120 G protein-coupled receptor 64 isoform 1 [Homo sapiens]
Length = 1017
Score = 37.4 bits (85), Expect = 0.059
Identities = 25/72 (34%), Positives = 35/72 (48%), Gaps = 9/72 (12%)
Query: 690 PQVYPPHSHSIPP----YQGLSPEESVNVLSAFQEPHLQMPPSLGQMSLPFDQPHPQGLL 745
P Y P +H++P Q LSP+ S + S+ P + MPP +S P Q H G
Sbjct: 282 PPDYSPVTHNVPSPIGEIQPLSPQPSAPIASS---PAIDMPPQSETISSPMPQTHVSGTP 338
Query: 746 PCQPQEHAVSSP 757
P P + + SSP
Sbjct: 339 P--PVKASFSSP 348
>gi|119943129 G protein-coupled receptor 64 isoform 4 [Homo sapiens]
Length = 1014
Score = 37.4 bits (85), Expect = 0.059
Identities = 25/72 (34%), Positives = 35/72 (48%), Gaps = 9/72 (12%)
Query: 690 PQVYPPHSHSIPP----YQGLSPEESVNVLSAFQEPHLQMPPSLGQMSLPFDQPHPQGLL 745
P Y P +H++P Q LSP+ S + S+ P + MPP +S P Q H G
Sbjct: 279 PPDYSPVTHNVPSPIGEIQPLSPQPSAPIASS---PAIDMPPQSETISSPMPQTHVSGTP 335
Query: 746 PCQPQEHAVSSP 757
P P + + SSP
Sbjct: 336 P--PVKASFSSP 345
>gi|56549668 AT rich interactive domain 2 (ARID, RFX-like) [Homo
sapiens]
Length = 1835
Score = 37.4 bits (85), Expect = 0.059
Identities = 61/256 (23%), Positives = 99/256 (38%), Gaps = 24/256 (9%)
Query: 545 QYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIRSLGD 604
QYVT+ N T + F + +TIA V Q +NI P + S
Sbjct: 852 QYVTTSASNIVSATSVQNFQVATGQMVTIAGVPSPQASRVGFQNIAPKPLPSQQVSS--- 908
Query: 605 RIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPELQMP 664
+ Q P++P ++ +P Q G+ Y PA ++ + LP +
Sbjct: 909 ---TVVQQPIQQPQQPTQQSVVIVSQPAQQGQT---YAPAIHQIVLANPAALPAGQTVQL 962
Query: 665 TMVPSYDLGMAPDSSMS-MQLGPDMVPQVYPPHSHSIPPYQGLSP--EESVNVLSAFQEP 721
T P+ + P SS S + + VP S S P QG P + ++V Q+
Sbjct: 963 TGQPN----ITPSSSPSPVPATNNQVPTAM--SSSSTPQSQGPPPTVSQMLSVKRQQQQQ 1016
Query: 722 HLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAFP 781
H PP Q+ + QP Q + QPQ+ P + ++++ L + + P
Sbjct: 1017 HSPAPPP-QQVQVQVQQPQ-QVQMQVQPQQSNAGVGQP-ASGESSLIKQLLLPKRGPSTP 1073
Query: 782 QGTWIGEDIFPPLLPP 797
G I + P +PP
Sbjct: 1074 GGKLI---LPAPQIPP 1086
>gi|148612809 WNK lysine deficient protein kinase 1 [Homo sapiens]
Length = 2382
Score = 36.6 bits (83), Expect = 0.10
Identities = 69/269 (25%), Positives = 93/269 (34%), Gaps = 73/269 (27%)
Query: 629 YKPEQMGKDGRGYVPATIKMT-VERDQPLPTPELQM-------PTMVPSYDLGMAPDSS- 679
Y P + + P++ +T V QP+ P+ Q P Y L SS
Sbjct: 708 YPPSSVAQGQSQGQPSSSSLTGVSSSQPIQHPQQQQGIQQTAPPQQTVQYSLSQTSTSSE 767
Query: 680 ------MSMQLGPDMVPQVYP----PHSHSIPPYQGLSPEESVNVLSAFQEPHLQMPPSL 729
+S P ++PQV P S +P QG E + V + +P + +P
Sbjct: 768 ATTAQPVSQPQAPQVLPQVSAGKQLPVSQPVPTIQG---EPQIPVAT---QPSV-VPVHS 820
Query: 730 GQMSLPFDQPHPQGLLPCQP-QEHAVSSP---------------------DPLL------ 761
G LP QP P LLP P + +S+P PLL
Sbjct: 821 GAHFLPVGQPLPTPLLPQYPVSQIPISTPHVSTAQTGFSSLPITMAAGITQPLLTLASSA 880
Query: 762 -------CSDVTMVEDSCLSQPVTAFPQGTWIGEDIFPPLLPPTEQDLTKLLLEGQGE-- 812
S V + L QPVT P + P LL P Q + GQ
Sbjct: 881 TTAAIPGVSTVVPSQLPTLLQPVTQLP------SQVHPQLLQPAVQSMGIPANLGQAAEV 934
Query: 813 --SGGGSL--GAQPLLQPSHYGQSGISMS 837
S G L G P L P + G S I+ S
Sbjct: 935 PLSSGDVLYQGFPPRLPPQYPGDSNIAPS 963
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 36.6 bits (83), Expect = 0.10
Identities = 39/155 (25%), Positives = 58/155 (37%), Gaps = 29/155 (18%)
Query: 653 DQPLPTPELQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSIPPYQGLSPEESV 712
+ PL P ++PT P ++P P+ P PP + P P E+
Sbjct: 551 ESPLSPPPEELPTSPPPEASRLSPP--------PEESPMSPPPEESPMSP-----PPEAS 597
Query: 713 NVLSAFQEPHLQMPPSLGQMSLPFD----QPHPQGLLPCQPQEHAVSSPDPLLCSDVTMV 768
+ F+E L PP +S P + P P+ P E + SP P + +
Sbjct: 598 RLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLP 657
Query: 769 EDSCLSQPVTAFPQGTWIGEDIFPPLLPPTEQDLT 803
S LS P P+ + PL PP E+ T
Sbjct: 658 VVSRLSPP----PEES--------PLSPPPEESPT 680
Score = 31.6 bits (70), Expect = 3.2
Identities = 33/131 (25%), Positives = 50/131 (38%), Gaps = 14/131 (10%)
Query: 676 PDSSMSMQLGPDM-------VPQVYPPHSHSIPPYQGLSPEESVNVLSAFQEPHLQMPPS 728
P +QL P + +P + PP + P SP S P ++P S
Sbjct: 418 PLGKAGVQLEPQLEAPLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPAS 477
Query: 729 LGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAFPQGTWIGE 788
+L +P + L P+E +S P S + +E+S LS P + P
Sbjct: 478 PLPEALHLSRPLEESPLSPPPEESPLSPPPE--SSPFSPLEESPLSPPEESPPSPA---- 531
Query: 789 DIFPPLLPPTE 799
+ PL PP E
Sbjct: 532 -LETPLSPPPE 541
Score = 30.8 bits (68), Expect = 5.5
Identities = 33/146 (22%), Positives = 56/146 (38%), Gaps = 10/146 (6%)
Query: 620 PKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPELQMPTMVPSYDLGMAPDSS 679
P+ E +PE+ R P ++ + ++P +P+ + P + + +
Sbjct: 736 PRSEGPHLSPRPEEPHLSPR---PEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQA 792
Query: 680 MSMQLGPD-----MVPQVYPPHSHSIPPYQGLSPEESVNVLS-AFQEPHLQMPPSLGQMS 733
L P + PQ PH +P LSP+ + LS +EP L P +S
Sbjct: 793 EGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLS 852
Query: 734 LPFDQPHPQGLLPCQPQEHAVSSPDP 759
++P P P +P E P P
Sbjct: 853 PELEKP-PLSPRPEKPPEEPGQCPAP 877
>gi|119393899 GLI-Kruppel family member GLI3 [Homo sapiens]
Length = 1580
Score = 36.2 bits (82), Expect = 0.13
Identities = 50/211 (23%), Positives = 84/211 (39%), Gaps = 46/211 (21%)
Query: 676 PDSSMSMQLGPDMVPQVYPPH---SHSIP-----PYQG-LSPEESVNVLSAFQEPHLQMP 726
P++ ++ + D+ P+ PP SHS P QG L ++ ++ ++ +E LQ+
Sbjct: 634 PEAHVTKKQRGDIHPRPPPPRDSGSHSQSRSPGRPTQGALGEQQDLSNTTSKREECLQVK 693
Query: 727 PSLGQMSLPFDQPHPQGLLPCQPQEHAVS---------------SPDPLLCSDVTMVEDS 771
+ + QP P G C Q+ +S S L D T + DS
Sbjct: 694 TVKAEKPMT-SQPSPGGQSSCSSQQSPISNYSNSGLELPLTDGGSIGDLSAIDETPIMDS 752
Query: 772 CLSQPVTAF-------PQGT-WIGE----------DIFP---PLLPPTEQDLTKLLLEGQ 810
+S TA P GT W+ +FP P+LPP ++ L+ G
Sbjct: 753 TISTATTALALQARRNPAGTKWMEHVKLERLKQVNGMFPRLNPILPPKAPAVSPLIGNGT 812
Query: 811 GESGGGSLGAQPLLQPSHYGQSGISMSHMDL 841
+ SLG L P SG+ ++ +++
Sbjct: 813 QSNNTCSLGGPMTLLPGRSDLSGVDVTMLNM 843
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo
sapiens]
Length = 1478
Score = 36.2 bits (82), Expect = 0.13
Identities = 41/145 (28%), Positives = 66/145 (45%), Gaps = 3/145 (2%)
Query: 101 QILQGEKKAVMEQFRHLPMPFHWKQEELKFKTGLRR-LQHRVGEIHLLREALQ-KGAEAG 158
Q L+ E+ V E R +EL+ K R L+ V E+ L+E L KG EA
Sbjct: 408 QALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEAD 467
Query: 159 QVSLHSLIETPANGTGPSEALAMLLQETTGELEAAKALVLKRIQIWKRQQQLAGNGAPFE 218
Q+ L E A+ + E LA L +E + E + L + + ++ Q L A
Sbjct: 468 QL-WRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVS 526
Query: 219 ESLAPLQERCESLVDIYSQLQQEVG 243
+ ++ L+E+ + L+ L Q+VG
Sbjct: 527 QHVSDLEEQKKQLIQDKDHLSQQVG 551
Score = 30.8 bits (68), Expect = 5.5
Identities = 20/72 (27%), Positives = 38/72 (52%), Gaps = 7/72 (9%)
Query: 179 LAMLLQETTGELEAAKALVLKRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQL 238
+A L +E +G+ + A Q+W+R Q+L + + +EE LA L+ + + L
Sbjct: 452 MAPLQEELSGKGQEAD-------QLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELL 504
Query: 239 QQEVGAAGGELE 250
+QEV + +L+
Sbjct: 505 EQEVRSLTRQLQ 516
>gi|146134388 YLP motif containing 1 [Homo sapiens]
Length = 2146
Score = 36.2 bits (82), Expect = 0.13
Identities = 29/110 (26%), Positives = 40/110 (36%), Gaps = 12/110 (10%)
Query: 655 PLPTPELQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSIPPYQGLSPEESVNV 714
P P P + P + PS + P + + P M P V PP + P G+ P
Sbjct: 527 PPPLPTMPPPVLPPSLPPPVMPPALPATVPPPGMPPPVMPPSLPTSVPPPGMPPS----- 581
Query: 715 LSAFQEPHLQMPPSLGQMSLP-------FDQPHPQGLLPCQPQEHAVSSP 757
LS+ P + PPSL P P ++P P A P
Sbjct: 582 LSSAGPPPVLPPPSLSSAGPPPVLPPPSLSSTAPPPVMPLPPLSSATPPP 631
Score = 32.0 bits (71), Expect = 2.5
Identities = 22/65 (33%), Positives = 28/65 (43%), Gaps = 4/65 (6%)
Query: 686 PDMVPQVY--PPHSHSIPPYQGLSPEESVNVLSAFQEPHLQMPPSLGQMSLPFDQPHPQG 743
P +VP PP S +PP + P +S + Q P PP+ Q LP QP P
Sbjct: 136 PGLVPMELESPPESPPVPPGSYMPPSQSY--MPPPQPPPSYYPPTSSQPYLPPAQPSPSQ 193
Query: 744 LLPCQ 748
P Q
Sbjct: 194 SPPSQ 198
>gi|50345997 E1A binding protein p300 [Homo sapiens]
Length = 2414
Score = 35.8 bits (81), Expect = 0.17
Identities = 49/205 (23%), Positives = 69/205 (33%), Gaps = 47/205 (22%)
Query: 640 GYVPATIKMTVERDQPLPTPELQMPTMVP-SYDLGMAPDSSMSMQLGPDMVPQVYPPH-- 696
G P T + QP PTP MP +P + G + Q+ P PQ P
Sbjct: 1860 GQQPTTPQTPQPTSQPQPTPPNSMPPYLPRTQAAGPVSQGKAAGQVTPPTPPQTAQPPLP 1919
Query: 697 ---------------------------------SHSIPPYQGLSPEESVNVLSAFQEPHL 723
H +PP ++P +N + P
Sbjct: 1920 GPPPAAVEMAMQIQRAAETQRQMAHVQIFQRPIQHQMPPMTPMAP-MGMNPPPMTRGPSG 1978
Query: 724 QMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAFPQG 783
+ P +G + P QG LP QPQ+ P P M+ + QP+ PQ
Sbjct: 1979 HLEPGMGPTGMQQQPPWSQGGLP-QPQQLQSGMPRP------AMMSVAQHGQPLNMAPQ- 2030
Query: 784 TWIGEDIFPPLLPPT--EQDLTKLL 806
+G+ PL P T +Q L LL
Sbjct: 2031 PGLGQVGISPLKPGTVSQQALQNLL 2055
Score = 35.0 bits (79), Expect = 0.29
Identities = 51/201 (25%), Positives = 77/201 (38%), Gaps = 40/201 (19%)
Query: 618 KKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLP-----------------TPE 660
+K +E R+ + + M + G VP ++ QP P P
Sbjct: 641 QKELEEKRRTRLQKQNMLPNAAGMVPVSMNPGPNMGQPQPGMTSNGPLPDPSMIRGSVPN 700
Query: 661 LQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSIPPYQGLSPEESVNVLSAFQE 720
MP + P L SM+ P +VP+ PP H + L+ ++N +
Sbjct: 701 QMMPRITPQSGLNQFGQMSMAQ---PPIVPRQTPPLQH----HGQLAQPGALNPPMGY-G 752
Query: 721 PHLQMPPSLGQMSLPFDQPHPQGL----LPCQPQEHAVSSPDPLLCSDVTMVEDSC-LSQ 775
P +Q P + GQ LP Q QG+ +P P S P+ S M SC ++
Sbjct: 753 PRMQQPSNQGQF-LPQTQFPSQGMNVTNIPLAPS----SGQAPV--SQAQMSSSSCPVNS 805
Query: 776 PVTAFPQGTWIGEDIFPPLLP 796
P+ P G+ G I P LP
Sbjct: 806 PI--MPPGSQ-GSHIHCPQLP 823
>gi|5174457 kinetochore associated 2 [Homo sapiens]
Length = 642
Score = 35.8 bits (81), Expect = 0.17
Identities = 61/270 (22%), Positives = 109/270 (40%), Gaps = 36/270 (13%)
Query: 47 AFCCNLAS--ALLSDTVQHLQASVGE-QGEGSTILQHISTLESIYQRDPLKLVATFRQIL 103
A+ NL S A+L + L + + E TI Q + L++I + R +
Sbjct: 312 AYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIER--I 369
Query: 104 QGEKKAVMEQFRHLPMPFHWKQ-----EELKFKTGLRRLQHRVGEIHLLREALQ---KGA 155
E+ + + L +Q EELK+ G ++ ++ E H L L+ KGA
Sbjct: 370 NHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKGA 429
Query: 156 EAG-----------QVSLHSLIETPANGTGPSEALAMLLQETTGELEAAKALVLKRIQIW 204
E + + L++ A P L LL ET E+ A + K++ +
Sbjct: 430 ENSKGYDFEIKFNPEAGANCLVKYRAQVYVP---LKELLNETEEEINKA---LNKKMGLE 483
Query: 205 KRQQQLAGNGAPFEESLAPLQERCESLVDIYSQ----LQQEVGAAGGELE--PKTRASLT 258
+QL + S+ L+E + L D+Y Q ++E ELE K + L
Sbjct: 484 DTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLE 543
Query: 259 GRLDEVLRTLVTSCFLVEKQPPQVLKTQTK 288
+++ L + V+++ V++T T+
Sbjct: 544 STVNQGLSEAMNELDAVQREYQLVVQTTTE 573
>gi|157412247 RUN and SH3 domain containing 1 isoform b [Homo
sapiens]
Length = 796
Score = 35.4 bits (80), Expect = 0.22
Identities = 29/115 (25%), Positives = 48/115 (41%), Gaps = 11/115 (9%)
Query: 318 EKQARELSVPQGPG--AGAESTGEIINNTVPLENS---IPGNCCSALFKNLLLKKIKRCE 372
E Q LS P PG G ES G V ++ +P CC L ++ E
Sbjct: 31 ELQEGPLSTPPPPGDTGGKESRGPCSGTLVDANSNSPAVPCRCCQEHGPGLENRQDPSQE 90
Query: 373 RKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDNNAKATIL 427
+G S ++ C+ S+ L P + P+ + LP G++D + + +I+
Sbjct: 91 EEGAASPSDPGCSSSLSSCSDLSPDESPVSVYLRDLP------GDEDAHPQPSII 139
>gi|157412245 RUN and SH3 domain containing 1 isoform a [Homo
sapiens]
Length = 902
Score = 35.4 bits (80), Expect = 0.22
Identities = 29/115 (25%), Positives = 48/115 (41%), Gaps = 11/115 (9%)
Query: 318 EKQARELSVPQGPG--AGAESTGEIINNTVPLENS---IPGNCCSALFKNLLLKKIKRCE 372
E Q LS P PG G ES G V ++ +P CC L ++ E
Sbjct: 31 ELQEGPLSTPPPPGDTGGKESRGPCSGTLVDANSNSPAVPCRCCQEHGPGLENRQDPSQE 90
Query: 373 RKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDNNAKATIL 427
+G S ++ C+ S+ L P + P+ + LP G++D + + +I+
Sbjct: 91 EEGAASPSDPGCSSSLSSCSDLSPDESPVSVYLRDLP------GDEDAHPQPSII 139
>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 1124
Score = 35.0 bits (79), Expect = 0.29
Identities = 31/127 (24%), Positives = 44/127 (34%), Gaps = 5/127 (3%)
Query: 655 PLPTPELQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSIPPYQGLSPEESVNV 714
P TP Q P + + L + P S + P P P + PP Q +
Sbjct: 687 PSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPP 746
Query: 715 LSAFQEPHLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLS 774
+S P ++PP L L P P LP P ++ P P + L
Sbjct: 747 MSPSATPPPRVPPLLAAPPLQV-PPSPPASLPMSP----LAKPPPQAPPALATPPLQALP 801
Query: 775 QPVTAFP 781
P +FP
Sbjct: 802 SPPASFP 808
Score = 31.6 bits (70), Expect = 3.2
Identities = 43/156 (27%), Positives = 52/156 (33%), Gaps = 22/156 (14%)
Query: 655 PLPTPELQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSI------------PP 702
PL TP Q P + L P S L P P P++ ++ PP
Sbjct: 613 PLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPP 672
Query: 703 YQG-LSPEESVNVLSAFQEPHLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLL 761
Q SP S V S P Q PPSL L P P P P P L
Sbjct: 673 VQAPFSPPASPPV-SPSATPPSQAPPSLAAPPLQV-PPSPPASPPMSPSATPPPQAPPPL 730
Query: 762 CSDVTMVEDSCLSQPVTAFPQGTWIGEDIFPPLLPP 797
+ V S + P + P T PP +PP
Sbjct: 731 AAPPLQVPPSPPASPPMS-PSAT------PPPRVPP 759
>gi|15812226 transcriptional regulating factor 1 [Homo sapiens]
Length = 1200
Score = 35.0 bits (79), Expect = 0.29
Identities = 54/241 (22%), Positives = 83/241 (34%), Gaps = 53/241 (21%)
Query: 628 HYKPEQMGKDGRGYVPA----TIKMTVERDQPLPTPELQMPTMVPSYDLGMAPDSSMSMQ 683
+Y P+Q + G+ + T + QP P P+ Q P + + +
Sbjct: 269 YYPPQQQQQAGQQRISMQEIQTQPQQIRPSQPQPPPQQQQPQQL-----------QLQQR 317
Query: 684 LGPDMVPQVYPPHSHSIPPYQGLSPEESVNVL----SAFQEPHLQMPPS--------LGQ 731
G +PQ Y P P Q L ++ + S ++PH P LG
Sbjct: 318 QGSMQIPQYYQPQ----PMMQHLQEQQQQQMHLQPPSYHRDPHQYTPEQAHTVQLIPLGS 373
Query: 732 MSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAFPQGTWIGE--D 789
MS + Q P QP H + L S EDS L + + D
Sbjct: 374 MSQYYYQE------PQQPYSHPLYQQSHL--SQHQQREDSQLKTYSSDRQAQAMLSSHGD 425
Query: 790 IFPP---LLPPTEQDLTKLLLEGQGESGGGSLGAQPLLQPSHYGQSGISMSHMDLRANPS 846
+ PP + P DLT++ +L +PLL PS + + H L +
Sbjct: 426 LGPPDTGMGDPASSDLTRV---------SSTLPHRPLLSPSGIHLNNMGPQHQQLSPSAM 476
Query: 847 W 847
W
Sbjct: 477 W 477
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,862,290
Number of Sequences: 37866
Number of extensions: 1817693
Number of successful extensions: 5344
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 159
Number of HSP's that attempted gapping in prelim test: 5102
Number of HSP's gapped (non-prelim): 339
length of query: 847
length of database: 18,247,518
effective HSP length: 111
effective length of query: 736
effective length of database: 14,044,392
effective search space: 10336672512
effective search space used: 10336672512
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.