Search of human proteins with 23312390

Search of human proteins with 23312390

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]
         (321 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]              661   0.0  
gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]              661   0.0  
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H...   661   0.0  
gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ...   197   1e-50
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]   191   7e-49
gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]     185   4e-47
gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec...   184   7e-47
gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]    179   4e-45
gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi...   178   5e-45
gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [...   177   1e-44
gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec...   174   1e-43
gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre...   174   1e-43
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec...   171   1e-42
gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec...   159   3e-39
gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr...   133   2e-31
gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [...   130   2e-30
gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]   127   1e-29
gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform...   113   2e-25
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform...   113   2e-25
gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ...   107   1e-23
gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p...   103   3e-22
gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform...    98   9e-21
gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]    79   4e-15
gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]    76   3e-14
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor...    70   3e-12
gi|223468705 5-hydroxytryptamine receptor 3 subunit D isoform 1 ...    57   2e-08
gi|47519877 5-hydroxytryptamine receptor 3 subunit D isoform 2 [...    51   2e-06
gi|206725456 zinc activated ligand-gated ion channel [Homo sapiens]    44   1e-04
gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3 is...    44   3e-04
gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3 iso...    44   3e-04

>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
          Length = 412

 Score =  661 bits (1705), Expect = 0.0
 Identities = 321/321 (100%), Positives = 321/321 (100%)

Query: 1   MQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPC 60
           MQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPC
Sbjct: 92  MQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPC 151

Query: 61  VLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTM 120
           VLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTM
Sbjct: 152 VLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTM 211

Query: 121 IIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQ 180
           IIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQ
Sbjct: 212 IIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQ 271

Query: 181 RRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLL 240
           RRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLL
Sbjct: 272 RRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLL 331

Query: 241 HGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTII 300
           HGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTII
Sbjct: 332 HGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTII 391

Query: 301 CTIGILMSAPNFVEAVSKDFA 321
           CTIGILMSAPNFVEAVSKDFA
Sbjct: 392 CTIGILMSAPNFVEAVSKDFA 412


>gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]
          Length = 321

 Score =  661 bits (1705), Expect = 0.0
 Identities = 321/321 (100%), Positives = 321/321 (100%)

Query: 1   MQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPC 60
           MQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPC
Sbjct: 1   MQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPC 60

Query: 61  VLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTM 120
           VLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTM
Sbjct: 61  VLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTM 120

Query: 121 IIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQ 180
           IIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQ
Sbjct: 121 IIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQ 180

Query: 181 RRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLL 240
           RRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLL
Sbjct: 181 RRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLL 240

Query: 241 HGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTII 300
           HGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTII
Sbjct: 241 HGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTII 300

Query: 301 CTIGILMSAPNFVEAVSKDFA 321
           CTIGILMSAPNFVEAVSKDFA
Sbjct: 301 CTIGILMSAPNFVEAVSKDFA 321


>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
           sapiens]
          Length = 502

 Score =  661 bits (1705), Expect = 0.0
 Identities = 321/321 (100%), Positives = 321/321 (100%)

Query: 1   MQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPC 60
           MQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPC
Sbjct: 182 MQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPC 241

Query: 61  VLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTM 120
           VLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTM
Sbjct: 242 VLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTM 301

Query: 121 IIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQ 180
           IIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQ
Sbjct: 302 IIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQ 361

Query: 181 RRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLL 240
           RRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLL
Sbjct: 362 RRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLL 421

Query: 241 HGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTII 300
           HGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTII
Sbjct: 422 HGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTII 481

Query: 301 CTIGILMSAPNFVEAVSKDFA 321
           CTIGILMSAPNFVEAVSKDFA
Sbjct: 482 CTIGILMSAPNFVEAVSKDFA 502


>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
           (neuronal) [Homo sapiens]
          Length = 529

 Score =  197 bits (500), Expect = 1e-50
 Identities = 118/327 (36%), Positives = 168/327 (51%), Gaps = 44/327 (13%)

Query: 2   QEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCV 61
           Q  D+  Y  +GEW +V   G  + + Y+CC E YPDVT+   +RR  L+Y +NL+IPC+
Sbjct: 218 QTVDLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCL 277

Query: 62  LISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMI 121
           LIS L +LVF LP+D GEKI+L I+VLLSLTVF+LL+ EI+P+TS  +PLI +Y   TMI
Sbjct: 278 LISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMI 337

Query: 122 IVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGED-------KVRP 174
            V LS+V+TV VL  HH  P    MP W R  LL     +L M RP          +++ 
Sbjct: 338 FVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKL 397

Query: 175 ACQHKQRRCSLASVEMSAVAPPP---ASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMAC 231
           +  +     ++ + E   V       A  G++                P  G +C     
Sbjct: 398 SPSYHWLESNVDAEEREVVVEEEDRWACAGHV---------------APSVGTLCSH--- 439

Query: 232 SPTHDEHLLHGGQPPEGD-----------PDLAKILEEVRYIANRFRCQDESEAVCSEWK 280
                 HL  G   P+ +           P + K LE V YIA+  R +D   +V  +WK
Sbjct: 440 -----GHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSVKEDWK 494

Query: 281 FAACVVDRLCLMAFSVFTIICTIGILM 307
           + A V+DR+ L  F +   + TIG+ +
Sbjct: 495 YVAMVIDRIFLWLFIIVCFLGTIGLFL 521


>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
          Length = 505

 Score =  191 bits (485), Expect = 7e-49
 Identities = 107/309 (34%), Positives = 175/309 (56%), Gaps = 15/309 (4%)

Query: 5   DISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLIS 64
           ++  Y  +GEW ++  PG + +  Y CC+E YPD+T+++ +RR  L+Y +NL+IPC+LIS
Sbjct: 197 NLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLIS 256

Query: 65  ALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVG 124
            L +LVF LP+D GEK++L I+VLLSLTVF+L++ E +P+TS  +PLI +Y   TMI V 
Sbjct: 257 FLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVT 316

Query: 125 LSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCS 184
           LS+V+TV VL  H+  P    MP W + + LN     + M RP  ++      + Q+   
Sbjct: 317 LSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNE-----GNAQKPRP 371

Query: 185 LASVEMSAVAPPPASNGNLLYIGFRGLDGV--HC----VPTPDSGVVCGRMACSPTHDEH 238
           L   E+S +     +       G+   DG+  +C    +   +      R + S + D  
Sbjct: 372 LYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAV 431

Query: 239 LLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFT 298
           L      PE    + + ++ V+YIA   + Q+E++ +  +WK+ A V+DR+ L  F++  
Sbjct: 432 LSLSALSPE----IKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVC 487

Query: 299 IICTIGILM 307
           I+ T G+ +
Sbjct: 488 ILGTAGLFL 496


>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
          Length = 498

 Score =  185 bits (470), Expect = 4e-47
 Identities = 111/308 (36%), Positives = 168/308 (54%), Gaps = 22/308 (7%)

Query: 4   ADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLI 63
           A +  + P+GEWD+V +PG+R+    +     Y DVT+   ++R+ L+Y +NL+IPCVL 
Sbjct: 190 ASMDDFTPSGEWDIVALPGRRTVNPQD---PSYVDVTYDFIIKRKPLFYTINLIIPCVLT 246

Query: 64  SALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIV 123
           + LA+LVF LP+D GEK++L I+VLL+LT F+LL+++I+P TS  VPLI +Y   TM++V
Sbjct: 247 TLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLV 306

Query: 124 GLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRC 183
             S+V +V VL  HH  P    M  W +   L+    FL MKRPG D   PA      + 
Sbjct: 307 TFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDS-SPARAFPPSKS 365

Query: 184 SLASVEMSAVAPPPAS-NGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPT---HDEHL 239
            +   E +A +  P++  GN +Y              P S         +P     D  L
Sbjct: 366 CVTKPEATATSTSPSNFYGNSMYF-----------VNPASAASKSPAGSTPVAIPRDFWL 414

Query: 240 LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI 299
              G+  +   D+ + LE V +IA   +  DE ++V  +WK+ A VVDRL L  F    +
Sbjct: 415 RSSGRFRQ---DVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCV 471

Query: 300 ICTIGILM 307
           + T+G+ +
Sbjct: 472 LGTVGLFL 479


>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
           precursor [Homo sapiens]
          Length = 502

 Score =  184 bits (468), Expect = 7e-47
 Identities = 103/307 (33%), Positives = 167/307 (54%), Gaps = 22/307 (7%)

Query: 4   ADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLI 63
           A +  + P+GEWD+V +PG+R+E   +     Y D+T+   +RR+ L+Y +NL+IPCVLI
Sbjct: 192 ASLDDFTPSGEWDIVALPGRRNENPDD---STYVDITYDFIIRRKPLFYTINLIIPCVLI 248

Query: 64  SALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIV 123
           ++LA+LVF LP+D GEK++L I+VLL+LTVF+LL+++I+P TS  VPL+ +Y   TM++V
Sbjct: 249 TSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLV 308

Query: 124 GLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRC 183
             S+V +V VL  HH  P    M  W +V+ L      L M++P     R   + ++R+ 
Sbjct: 309 TFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQR 368

Query: 184 SLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGG 243
                        P ++    ++    + G           + G     P         G
Sbjct: 369 EREGAGALFFREAPGADSCTCFVNRASVQG-----------LAGAFGAEPAP-----VAG 412

Query: 244 QPPEGDP---DLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTII 300
               G+P    L + ++ VR+IA+  R +D+ ++V  +WK+ A V+DRL L  F    + 
Sbjct: 413 PGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVF 472

Query: 301 CTIGILM 307
            TIG+ +
Sbjct: 473 GTIGMFL 479


>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
          Length = 494

 Score =  179 bits (453), Expect = 4e-45
 Identities = 102/312 (32%), Positives = 167/312 (53%), Gaps = 28/312 (8%)

Query: 3   EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVL 62
           + D++ +  N EW+++   G + +  Y CC+E Y D+T++  +RR  ++Y +NL+IPC+ 
Sbjct: 194 KVDMNDFWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLF 253

Query: 63  ISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMII 122
           IS L +LVF LP+D GEK++L I+VLLSLTVF+L++ E +P+TS  VPL+ +Y   TMI 
Sbjct: 254 ISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIF 313

Query: 123 VGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRP-------GEDKVRPA 175
           V LS+VVTV VL  H+  P    MP+W + + L      L M+ P       G D V   
Sbjct: 314 VTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRG 373

Query: 176 CQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTH 235
              +  +  L            AS+G   ++     +  HC  + +      R++  P  
Sbjct: 374 LARRPAKGKL------------ASHGEPRHL----KECFHCHKSNELATSKRRLSHQP-- 415

Query: 236 DEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFS 295
              L    +  E  P++  ++  V++IA   +  +E++ V  +WK+ A VVDR+ L  F 
Sbjct: 416 ---LQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFI 472

Query: 296 VFTIICTIGILM 307
           +  +  T G+ +
Sbjct: 473 IVCVFGTAGLFL 484


>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
           sapiens]
          Length = 450

 Score =  178 bits (452), Expect = 5e-45
 Identities = 112/306 (36%), Positives = 157/306 (51%), Gaps = 47/306 (15%)

Query: 4   ADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLI 63
           A ++ ++ N EW ++G+P +R    Y CC EPYPDVTFT+ +RRR   Y  NLL+PCVLI
Sbjct: 191 ASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLI 250

Query: 64  SALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIV 123
           S LA L F LPADSGEK+SLG+TVLL+LTVF LL+AE MP  ++SVPLI +Y+ +TM +V
Sbjct: 251 SLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMP-PAESVPLIGKYYMATMTMV 309

Query: 124 GLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRC 183
             S  +T++++  H+  P    +P W R +LL   A  L ++  GE    P  Q +    
Sbjct: 310 TFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGE----PCGQSRPPEL 365

Query: 184 SLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGG 243
           S +       A PPA                   P  +   +C          E LLH  
Sbjct: 366 SPSPQSPEGGAGPPAG------------------PCHEPRCLC--------RQEALLH-- 397

Query: 244 QPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTI 303
                          V  IAN FR    ++    +WK  A V+DR  L  F    ++ ++
Sbjct: 398 --------------HVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSL 443

Query: 304 GILMSA 309
            +L+ A
Sbjct: 444 LVLVQA 449


>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
           [Homo sapiens]
          Length = 479

 Score =  177 bits (448), Expect = 1e-44
 Identities = 109/320 (34%), Positives = 168/320 (52%), Gaps = 41/320 (12%)

Query: 1   MQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPC 60
           +   D+S +I + EW++ G+P  ++   Y CC EPYPDVTFT+ ++RR+ +Y +NLLIPC
Sbjct: 189 LDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPC 248

Query: 61  VLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTM 120
           VLIS LA L F LPA SGEK+SLG+T+LL++TVF L+VAEIMPA S++VPLI +Y+ +TM
Sbjct: 249 VLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPA-SENVPLIGKYYIATM 307

Query: 121 IIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQ 180
            ++  S  +T++V+  H    +   +P W RV++L + +  L +   GE  + P   H +
Sbjct: 308 ALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLSP--HHSR 365

Query: 181 RRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGR---MACSPTHDE 237
            R  L  V                               P+S +   R   ++     ++
Sbjct: 366 ERDHLTKVYSK---------------------------LPESNLKAARNKDLSRKKDMNK 398

Query: 238 HL-----LHGGQPPEGDPDLAK---ILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRL 289
            L       G  P E +   A+   +   + YIA   +    + +  SEWK  A V+DR 
Sbjct: 399 RLKNDLGCQGKNPQEAESYCAQYKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRF 458

Query: 290 CLMAFSVFTIICTIGILMSA 309
            +  F +   + TI I+  A
Sbjct: 459 FMWIFFIMVFVMTILIIARA 478


>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
           precursor [Homo sapiens]
          Length = 457

 Score =  174 bits (440), Expect = 1e-43
 Identities = 103/312 (33%), Positives = 162/312 (51%), Gaps = 60/312 (19%)

Query: 3   EADISGYIPNGEWDLVGIPGKRSERFYECCKE-PYPDVTFTVTMRRRTLYYGLNLLIPCV 61
           + D+S ++ +GEW +    G +    Y CC + PY D+T+   M+R  LY+ +N++IPC+
Sbjct: 184 QPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCL 243

Query: 62  LISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMI 121
           L S L  LVF LP DSGEK++L I+VLLSLTVF+L++ E++P+TS +VPLI +Y   TM+
Sbjct: 244 LFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMV 303

Query: 122 IVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNW---CAWFLRMKRPGEDKVRPACQH 178
            V  S+++TVIV+  HH  P    MP W R + ++      +F  MKRP  +K       
Sbjct: 304 FVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREK------- 356

Query: 179 KQRRCSLASVEMSAVA----PPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPT 234
           + ++     +++S ++    PPP        +GF                          
Sbjct: 357 QDKKIFTEDIDISDISGKPGPPP--------MGF-------------------------- 382

Query: 235 HDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAF 294
           H   + H        P++   +E ++YIA   +   ES    +EWK+ A V+D + L   
Sbjct: 383 HSPLIKH--------PEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILL--- 431

Query: 295 SVFTIICTIGIL 306
            VF ++C IG L
Sbjct: 432 GVFMLVCIIGTL 443


>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
           precursor [Homo sapiens]
          Length = 482

 Score =  174 bits (440), Expect = 1e-43
 Identities = 103/312 (33%), Positives = 162/312 (51%), Gaps = 60/312 (19%)

Query: 3   EADISGYIPNGEWDLVGIPGKRSERFYECCKE-PYPDVTFTVTMRRRTLYYGLNLLIPCV 61
           + D+S ++ +GEW +    G +    Y CC + PY D+T+   M+R  LY+ +N++IPC+
Sbjct: 209 QPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCL 268

Query: 62  LISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMI 121
           L S L  LVF LP DSGEK++L I+VLLSLTVF+L++ E++P+TS +VPLI +Y   TM+
Sbjct: 269 LFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMV 328

Query: 122 IVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNW---CAWFLRMKRPGEDKVRPACQH 178
            V  S+++TVIV+  HH  P    MP W R + ++      +F  MKRP  +K       
Sbjct: 329 FVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREK------- 381

Query: 179 KQRRCSLASVEMSAVA----PPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPT 234
           + ++     +++S ++    PPP        +GF                          
Sbjct: 382 QDKKIFTEDIDISDISGKPGPPP--------MGF-------------------------- 407

Query: 235 HDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAF 294
           H   + H        P++   +E ++YIA   +   ES    +EWK+ A V+D + L   
Sbjct: 408 HSPLIKH--------PEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILL--- 456

Query: 295 SVFTIICTIGIL 306
            VF ++C IG L
Sbjct: 457 GVFMLVCIIGTL 468


>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
           precursor [Homo sapiens]
          Length = 627

 Score =  171 bits (432), Expect = 1e-42
 Identities = 89/192 (46%), Positives = 119/192 (61%), Gaps = 2/192 (1%)

Query: 12  NGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVF 71
           +GEW +V   G  + R YECC E YPD+T+   +RR  L+Y +NL+IPC+LIS L +LVF
Sbjct: 206 SGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVF 265

Query: 72  LLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTV 131
            LP++ GEKI+L I+VLLSLTVF+LL+ EI+P+TS  +PLI +Y   TMI V LS+V+TV
Sbjct: 266 YLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITV 325

Query: 132 IVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPG--EDKVRPACQHKQRRCSLASVE 189
            VL  HH  P    MP W R + L+     L MKRP   +D  R   +   +  S     
Sbjct: 326 FVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFW 385

Query: 190 MSAVAPPPASNG 201
                 PPA++G
Sbjct: 386 PEPEGEPPATSG 397



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 19/58 (32%), Positives = 36/58 (62%)

Query: 250 PDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILM 307
           P L + +E V+YIA+  + +D   +V  +WK+ A V+DR+ L  F +  ++ T+G+ +
Sbjct: 562 PALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFL 619


>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
           precursor [Homo sapiens]
          Length = 501

 Score =  159 bits (402), Expect = 3e-39
 Identities = 103/318 (32%), Positives = 164/318 (51%), Gaps = 46/318 (14%)

Query: 9   YIPNGEWDLVGIPGKRSERFYECCKEPY-------PDVTFTVTMRRRTLYYGLNLLIPCV 61
           +I NG+W+++  P     R  +   +P         +V F + +RR+ L+Y +N++ PC+
Sbjct: 202 FIENGQWEIIHKPS----RLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCI 257

Query: 62  LISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMI 121
           LI+ LA+ VF LP D+GEK+ L I  LL+LTVF+LL+A+ +P TS SVP+I +Y   TM+
Sbjct: 258 LITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMV 317

Query: 122 IVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDK----VRPACQ 177
           +V  SV+++V+VL  HH  P   +MP W R I ++    +LR+KRP  ++      P C 
Sbjct: 318 LVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLKRPKPERDLMPEPPHCS 377

Query: 178 HKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPD------SGVVCGRMAC 231
                    + E     PP     + L+            P P+      S     R   
Sbjct: 378 SPGSGWGRGTDEYFIRKPP----SDFLF------------PKPNRFQPELSAPDLRRFID 421

Query: 232 SPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCL 291
            P     LL         P+L +++  + YIA + + Q++ +A+  +W+F A VVDRL L
Sbjct: 422 GPNRAVALL---------PELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFL 472

Query: 292 MAFSVFTIICTIGILMSA 309
             F +FT + T+ I + A
Sbjct: 473 WTFIIFTSVGTLVIFLDA 490


>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  133 bits (335), Expect = 2e-31
 Identities = 94/304 (30%), Positives = 146/304 (48%), Gaps = 15/304 (4%)

Query: 5   DISGYIPNGEWDLVGIPGKRSERFYECCKEPY-PDVTFTVTMRRRTLYYGLNLLIPCVLI 63
           D  G+  NGEW++V  P + +         P   D+TF + +RR+ L+Y +N+L+PCVLI
Sbjct: 201 DPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLI 260

Query: 64  SALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIV 123
           S +  LVF LPADSGEK S+ I+VLL+ +VF+LL+++ +PATS ++PLI ++    M++V
Sbjct: 261 SFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLV 320

Query: 124 GLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRC 183
            + VV+ VIVL  H   P    + +  + + L      L M RP ED   P     +R  
Sbjct: 321 TMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGAL-VRRSS 379

Query: 184 SLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGG 243
           SL  +  +       S  +L++       G+    T        R   S    +  L   
Sbjct: 380 SLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLT-----TARRPPASSEQAQQELFN- 433

Query: 244 QPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTI 303
                  +L   ++   +I N  R Q+        W   A  VDRLCL   +   ++ T 
Sbjct: 434 -------ELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTA 486

Query: 304 GILM 307
            I +
Sbjct: 487 WIFL 490


>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
           [Homo sapiens]
          Length = 458

 Score =  130 bits (326), Expect = 2e-30
 Identities = 90/312 (28%), Positives = 142/312 (45%), Gaps = 54/312 (17%)

Query: 2   QEADISGYIPNGEWDLV---GIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLI 58
           +  D   +  NGEW+++   G+ G R +  Y      YP +T++  +RR  L+Y L L+I
Sbjct: 188 ENVDRKDFFDNGEWEILNAKGMKGNRRDGVYS-----YPFITYSFVLRRLPLFYTLFLII 242

Query: 59  PCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAS 118
           PC+ +S L +LVF LP+D GEK+SL  +VL+SLTVF+L++ EI+P++S  +PLI +Y   
Sbjct: 243 PCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLF 302

Query: 119 TMIIVGLSVVVTVIVLQYHHHDPDG-GKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQ 177
            MI V LS++VTV V+  HH        M  W + + L      L MK   +    P  +
Sbjct: 303 IMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPEKE 362

Query: 178 HKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDE 237
             Q       +E         S+G  + + F                             
Sbjct: 363 ESQPVVKGKVLEKK--KQKQLSDGEKVLVAF----------------------------- 391

Query: 238 HLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVF 297
                         L K  + +RYI+   + +     V  +WKF A V+DR+ L  F + 
Sbjct: 392 --------------LEKAADSIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIV 437

Query: 298 TIICTIGILMSA 309
           ++  ++ I   A
Sbjct: 438 SVTGSVLIFTPA 449


>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
          Length = 468

 Score =  127 bits (320), Expect = 1e-29
 Identities = 62/137 (45%), Positives = 91/137 (66%), Gaps = 2/137 (1%)

Query: 2   QEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCV 61
           Q+ D   +  NGEW++V   G +  R   CC  PY  VT++  ++R  L+Y L L+IPC+
Sbjct: 205 QDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWYPY--VTYSFVIKRLPLFYTLFLIIPCI 262

Query: 62  LISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMI 121
            +S L +LVF LP++ GEKI L  +VL+SLTVF+L++ EI+P++S  +PLI +Y   TMI
Sbjct: 263 GLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMI 322

Query: 122 IVGLSVVVTVIVLQYHH 138
            V LS++VTV  +  HH
Sbjct: 323 FVTLSIMVTVFAINIHH 339



 Score = 42.4 bits (98), Expect = 6e-04
 Identities = 21/74 (28%), Positives = 35/74 (47%)

Query: 234 THDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMA 293
           T  E    G  P      L   L+ +RYI      +++   V  +WKF A V+DR+ L  
Sbjct: 375 TQKEETESGSGPKSSRNTLEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWT 434

Query: 294 FSVFTIICTIGILM 307
           F   +I+ ++G+ +
Sbjct: 435 FLFVSIVGSLGLFV 448


>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
           precursor [Homo sapiens]
          Length = 484

 Score =  113 bits (283), Expect = 2e-25
 Identities = 79/309 (25%), Positives = 143/309 (46%), Gaps = 39/309 (12%)

Query: 3   EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVL 62
           ++D S ++  GEW+L+G+     E   E     Y ++ F V +RRR L+Y ++LL+P + 
Sbjct: 203 KSDRSVFMNQGEWELLGVLPYFREFSMESSNY-YAEMKFYVVIRRRPLFYVVSLLLPSIF 261

Query: 63  ISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMII 122
           +  + ++ F LP +SGE++S  IT+LL  +VF+++V++ +PAT+   PLI  YF   M +
Sbjct: 262 LMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMAL 321

Query: 123 VGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRR 182
           + +S+  T+ +++  H       +P W R ++L   AW L ++     +  PA     + 
Sbjct: 322 LVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKT 381

Query: 183 CSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHC--VPTPDSGVVCGRMACSPTHDEHLL 240
              +++                        G HC  +  P       R  CSP       
Sbjct: 382 DDCSAM------------------------GNHCSHMGGPQDFEKSPRDRCSPP------ 411

Query: 241 HGGQPPEGDPDLAK--ILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFT 298
               PP  +  LA   +L+E+  I      +DE   V  +W     V+D+L    + +  
Sbjct: 412 ----PPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAV 467

Query: 299 IICTIGILM 307
           +  +I ++M
Sbjct: 468 LAYSITLVM 476


>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
           [Homo sapiens]
          Length = 463

 Score =  113 bits (283), Expect = 2e-25
 Identities = 79/309 (25%), Positives = 143/309 (46%), Gaps = 39/309 (12%)

Query: 3   EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVL 62
           ++D S ++  GEW+L+G+     E   E     Y ++ F V +RRR L+Y ++LL+P + 
Sbjct: 182 KSDRSVFMNQGEWELLGVLPYFREFSMESSNY-YAEMKFYVVIRRRPLFYVVSLLLPSIF 240

Query: 63  ISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMII 122
           +  + ++ F LP +SGE++S  IT+LL  +VF+++V++ +PAT+   PLI  YF   M +
Sbjct: 241 LMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMAL 300

Query: 123 VGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRR 182
           + +S+  T+ +++  H       +P W R ++L   AW L ++     +  PA     + 
Sbjct: 301 LVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKT 360

Query: 183 CSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHC--VPTPDSGVVCGRMACSPTHDEHLL 240
              +++                        G HC  +  P       R  CSP       
Sbjct: 361 DDCSAM------------------------GNHCSHMGGPQDFEKSPRDRCSPP------ 390

Query: 241 HGGQPPEGDPDLAK--ILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFT 298
               PP  +  LA   +L+E+  I      +DE   V  +W     V+D+L    + +  
Sbjct: 391 ----PPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAV 446

Query: 299 IICTIGILM 307
           +  +I ++M
Sbjct: 447 LAYSITLVM 455


>gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
           precursor [Homo sapiens]
          Length = 493

 Score =  107 bits (267), Expect = 1e-23
 Identities = 87/311 (27%), Positives = 139/311 (44%), Gaps = 36/311 (11%)

Query: 3   EADISGYIPNGEWDLVGIPGKRSERFYECCKEP-YPDVTFTVTMRRRTLYYGLNLLIPCV 61
           + D   Y  NGEW +   PG            P   DV +++ +RR+ L+Y +N+++PCV
Sbjct: 193 DIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCV 252

Query: 62  LISALALLVFLLPADSG-EKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTM 120
           LIS L LL + LPA +G +K ++ I VLL+ TVF+ L+A+ +P TS SVPL+ ++    M
Sbjct: 253 LISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVM 312

Query: 121 IIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQ 180
           ++  L V+  VIVL      P    M    R +LL      L    P E    P      
Sbjct: 313 VVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPE---APRAASPP 369

Query: 181 RRCSLASVEMSA---VAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDE 237
           RR S   + + A   +   P S   L++ G R   G        +   C  +  +     
Sbjct: 370 RRASSVGLLLRAEELILKKPRS--ELVFEGQRHRQGTW------TAAFCQSLGAAA---- 417

Query: 238 HLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLC----LMA 293
                       P++   ++ V ++A   R Q+ +    S+W      +D +C    L+ 
Sbjct: 418 ------------PEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVL 465

Query: 294 FSVFTIICTIG 304
           FSV + +  +G
Sbjct: 466 FSVGSSLIFLG 476


>gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  103 bits (256), Expect = 3e-22
 Identities = 92/321 (28%), Positives = 140/321 (43%), Gaps = 37/321 (11%)

Query: 5   DISGYIPNGEWDLVGIPGKRSERFYECCKEP-YPDVTFTVTMRRRTLYYGLNLLIPCVLI 63
           D   +  NGEW +   P K         +E  +  V F + ++R+ L+Y +N++ PCVLI
Sbjct: 196 DPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPLFYVINIIAPCVLI 255

Query: 64  SALALLVFLLPADSG-EKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMII 122
           S++A+L+  LPA +G +K ++ I VLL+ TVF+ LVA+ +P TS +VPLI++Y    +++
Sbjct: 256 SSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLLVV 315

Query: 123 VGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRP----ACQH 178
             L VV  V+VL      P    M +  R + L      LRM       VRP    A Q 
Sbjct: 316 TILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRM------HVRPLAPAAVQD 369

Query: 179 KQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPD--------SGVVCGRMA 230
            Q R                 NG+  +    G +   C+P  +         G+V   + 
Sbjct: 370 TQSR---------------LQNGSSGWSITTGEEVALCLPRSELLFQQWQRQGLVAAALE 414

Query: 231 CSPTHDEHLLHG--GQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDR 288
                 E  L    G   +  P +   +E    IA     Q   +    EW     V+DR
Sbjct: 415 KLEKGPELGLSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVLDR 474

Query: 289 LCLMAFSVFTIICTIGILMSA 309
           +C +A     I  T GI + A
Sbjct: 475 VCFLAMLSLFICGTAGIFLMA 495


>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
           precursor [Homo sapiens]
          Length = 516

 Score = 98.2 bits (243), Expect = 9e-21
 Identities = 79/341 (23%), Positives = 144/341 (42%), Gaps = 71/341 (20%)

Query: 3   EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVL 62
           ++D S ++  GEW+L+G+     E   E     Y ++ F V +RRR L+Y ++LL+P + 
Sbjct: 203 KSDRSVFMNQGEWELLGVLPYFREFSMESSNY-YAEMKFYVVIRRRPLFYVVSLLLPSIF 261

Query: 63  ISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQ-------- 114
           +  + ++ F LP +SGE++S  IT+LL  +VF+++V++ +PAT+   PLI +        
Sbjct: 262 LMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQ 321

Query: 115 ------------------------YFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWT 150
                                   YF   M ++ +S+  T+ +++  H       +P W 
Sbjct: 322 SGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWL 381

Query: 151 RVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRG 210
           R ++L   AW L ++     +  PA     +    +++                      
Sbjct: 382 RHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAM---------------------- 419

Query: 211 LDGVHC--VPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLA--KILEEVRYIANRF 266
             G HC  +  P       R  CSP           PP  +  LA   +L+E+  I    
Sbjct: 420 --GNHCSHMGGPQDFEKSPRDRCSP----------PPPPREASLAVCGLLQELSSIRQFL 467

Query: 267 RCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILM 307
             +DE   V  +W     V+D+L    + +  +  +I ++M
Sbjct: 468 EKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVM 508


>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
          Length = 447

 Score = 79.3 bits (194), Expect = 4e-15
 Identities = 49/145 (33%), Positives = 79/145 (54%), Gaps = 5/145 (3%)

Query: 13  GEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFL 72
           GEW+L+GI   ++          Y  + F V +RRR   Y +NLL+P   + A+  L F 
Sbjct: 213 GEWELLGI--NKATPKMSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFY 270

Query: 73  LPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTV- 131
           LPA+S  +    IT+LL   VF+L++ +++PA+    PLI+ YFA  + ++ +S++ TV 
Sbjct: 271 LPAESENRAPFKITLLLGYNVFLLMMNDLLPAS--GTPLISVYFALCLSLMVVSLLETVF 328

Query: 132 IVLQYHHHDPDGGKMPKWTRVILLN 156
           I    H        MP+W   +LL+
Sbjct: 329 ITYLLHVATTQPPPMPRWLHSLLLH 353


>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
          Length = 471

 Score = 76.3 bits (186), Expect = 3e-14
 Identities = 44/146 (30%), Positives = 78/146 (53%), Gaps = 5/146 (3%)

Query: 12  NGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVF 71
           +GEW+L+G+   ++          Y  + F V +RRR   Y +NLL+P   + A+  L F
Sbjct: 227 HGEWELLGL--SKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSF 284

Query: 72  LLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTV 131
            LP  SG ++   IT+LL   VF+L++++++P  +   PLI  YFA  + ++  S++ T+
Sbjct: 285 YLPVKSGNRVPFKITLLLGYNVFLLMMSDLLP--TSGTPLIGVYFALCLSLMVGSLLETI 342

Query: 132 IVLQ-YHHHDPDGGKMPKWTRVILLN 156
            +    H        +P+W   +LL+
Sbjct: 343 FITHLLHVATTQPPPLPRWLHSLLLH 368


>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
           [Homo sapiens]
          Length = 441

 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 38/141 (26%), Positives = 73/141 (51%), Gaps = 2/141 (1%)

Query: 5   DISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLIS 64
           D   ++ + EW+L+ +    S    +     +  + F V MRR  L Y ++LLIP + + 
Sbjct: 197 DKKAFLNDSEWELLSVSSTYS--ILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLM 254

Query: 65  ALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVG 124
            + L  F LP +   +I    +VL+  TVF + ++  +P +  S PLI  +F   M  + 
Sbjct: 255 LVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLV 314

Query: 125 LSVVVTVIVLQYHHHDPDGGK 145
           LS+  +++++++ H +  GG+
Sbjct: 315 LSLAKSIVLVKFLHDEQRGGQ 335


>gi|223468705 5-hydroxytryptamine receptor 3 subunit D isoform 1
           [Homo sapiens]
          Length = 404

 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 56/206 (27%), Positives = 92/206 (44%), Gaps = 27/206 (13%)

Query: 14  EWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLY--YGLNLLIPCVLISALALLVF 71
           EW L+GI  KR+ +      + Y    F V +RRR     Y +N L+P  ++ A+  L F
Sbjct: 146 EWVLLGIQ-KRTIKVTVATNQ-YEQAIFHVAIRRRCRPSPYVVNFLVPSGILIAIDALSF 203

Query: 72  LLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDS--VPLI----------AQYFAST 119
            LP +SG      +TVLL  +VF+L++ +++PATS S    L+            YFA  
Sbjct: 204 YLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGVYFALC 263

Query: 120 MIIVGLSVVVTVIVLQ-YHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQH 178
           + ++  S++ T+ +    H        +P+W   +LL+ C         G+ +  P    
Sbjct: 264 LSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLH-CT--------GQGRCCPTAPQ 314

Query: 179 K-QRRCSLASVEMSAVAPPPASNGNL 203
           K  +   L    +  V  P  S G +
Sbjct: 315 KGNKGPGLTPTHLPGVKEPEVSAGQM 340


>gi|47519877 5-hydroxytryptamine receptor 3 subunit D isoform 2
           [Homo sapiens]
          Length = 279

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 45/175 (25%), Positives = 77/175 (44%), Gaps = 23/175 (13%)

Query: 43  VTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIM 102
           +  R R   Y +N L+P  ++ A+  L F LP +SG      +TVLL  +VF+L++ +++
Sbjct: 50  IRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLL 109

Query: 103 PATSDS--VPLI----------AQYFASTMIIVGLSVVVTVIVLQ-YHHHDPDGGKMPKW 149
           PATS S    L+            YFA  + ++  S++ T+ +    H        +P+W
Sbjct: 110 PATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRW 169

Query: 150 TRVILLNWCAWFLRMKRPGEDKVRPACQHK-QRRCSLASVEMSAVAPPPASNGNL 203
              +LL+ C         G+ +  P    K  +   L    +  V  P  S G +
Sbjct: 170 LHSLLLH-CT--------GQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQM 215


>gi|206725456 zinc activated ligand-gated ion channel [Homo sapiens]
          Length = 412

 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 26/97 (26%), Positives = 50/97 (51%)

Query: 37  PDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFML 96
           P    T+ ++   L   + LL+P   +    +   LLP  + E+I   +T+LLS  V   
Sbjct: 218 PCFQVTLRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHS 277

Query: 97  LVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIV 133
            + + +P++S   PL+  YF   ++++ LS + TV++
Sbjct: 278 SLVQALPSSSSCNPLLIYYFTILLLLLFLSTIETVLL 314


>gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3
           isoform 2 precursor [Homo sapiens]
          Length = 473

 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 28/102 (27%), Positives = 55/102 (53%), Gaps = 8/102 (7%)

Query: 36  YPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPAD-SGEKISLGITVLLSLTVF 94
           YP ++ +  ++R   Y+ L   +P +LI+ L+ + F +  D S  +++LGIT +L++T  
Sbjct: 230 YPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTI 289

Query: 95  MLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQY 136
              + E +P     +P +    A  M ++G  V V + +L+Y
Sbjct: 290 NTHLRETLP----KIPYVK---AIDMYLMGCFVFVFLALLEY 324


>gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3
           isoform 1 precursor [Homo sapiens]
          Length = 473

 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 28/102 (27%), Positives = 55/102 (53%), Gaps = 8/102 (7%)

Query: 36  YPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPAD-SGEKISLGITVLLSLTVF 94
           YP ++ +  ++R   Y+ L   +P +LI+ L+ + F +  D S  +++LGIT +L++T  
Sbjct: 230 YPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTI 289

Query: 95  MLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQY 136
              + E +P     +P +    A  M ++G  V V + +L+Y
Sbjct: 290 NTHLRETLP----KIPYVK---AIDMYLMGCFVFVFLALLEY 324


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.140    0.447 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,566,364
Number of Sequences: 37866
Number of extensions: 644711
Number of successful extensions: 1847
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 1763
Number of HSP's gapped (non-prelim): 81
length of query: 321
length of database: 18,247,518
effective HSP length: 102
effective length of query: 219
effective length of database: 14,385,186
effective search space: 3150355734
effective search space used: 3150355734
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.