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Search of human proteins with 22902128
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor
[Homo sapiens]
(940 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [... 1912 0.0
gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [... 1617 0.0
gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [... 1134 0.0
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [... 1116 0.0
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 230 4e-60
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo... 226 1e-58
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo... 226 1e-58
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo... 226 1e-58
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 224 3e-58
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 223 7e-58
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 223 9e-58
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 223 9e-58
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 223 9e-58
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 223 9e-58
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor... 222 1e-57
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 222 1e-57
gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isofo... 221 3e-57
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 220 4e-57
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo... 220 6e-57
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 219 9e-57
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 219 9e-57
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 219 9e-57
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 218 2e-56
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 218 2e-56
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens] 217 4e-56
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo... 214 3e-55
gi|29029632 anaplastic lymphoma kinase [Homo sapiens] 210 4e-54
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 207 5e-53
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 207 5e-53
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 207 5e-53
>gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor
[Homo sapiens]
Length = 940
Score = 1912 bits (4952), Expect = 0.0
Identities = 940/940 (100%), Positives = 940/940 (100%)
Query: 1 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP
Sbjct: 1 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
Query: 61 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN
Sbjct: 61 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
Query: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS
Sbjct: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
Query: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE
Sbjct: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
Query: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR
Sbjct: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
Query: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG
Sbjct: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
Query: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVANGSSLPEWVTD 420
VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVANGSSLPEWVTD
Sbjct: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVANGSSLPEWVTD 420
Query: 421 NAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTAL 480
NAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTAL
Sbjct: 421 NAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTAL 480
Query: 481 LQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSC 540
LQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSC
Sbjct: 481 LQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSC 540
Query: 541 NIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRC 600
NIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRC
Sbjct: 541 NIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRC 600
Query: 601 KAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMH 660
KAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMH
Sbjct: 601 KAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMH 660
Query: 661 FPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMF 720
FPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMF
Sbjct: 661 FPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMF 720
Query: 721 GKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVAL 780
GKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVAL
Sbjct: 721 GKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVAL 780
Query: 781 CTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPL 840
CTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPL
Sbjct: 781 CTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPL 840
Query: 841 RWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPE 900
RWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPE
Sbjct: 841 RWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPE 900
Query: 901 GCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 940
GCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP
Sbjct: 901 GCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 940
>gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [Homo
sapiens]
Length = 1014
Score = 1617 bits (4188), Expect = 0.0
Identities = 838/1023 (81%), Positives = 856/1023 (83%), Gaps = 92/1023 (8%)
Query: 1 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP
Sbjct: 1 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
Query: 61 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN
Sbjct: 61 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
Query: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS
Sbjct: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
Query: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE
Sbjct: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
Query: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR
Sbjct: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
Query: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG
Sbjct: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
Query: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVANGSSLPEWVTD 420
VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA ++P W+
Sbjct: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA---TVPSWLKK 417
Query: 421 --------------------------------------------NAGTLHFARVTRDDAG 436
GTL V D
Sbjct: 418 PQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGT 477
Query: 437 NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQ-GHTALLQCEAQGDPKPLIQW 495
Y C++S P G I A ++ V + F P+ + A + C A G KP I+W
Sbjct: 478 WYRCMSST-PAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKW 536
Query: 496 KGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGN----------------- 538
+ D P + G+L V +D+G YTCIA N
Sbjct: 537 ERADGSSLPEWVTDNA-----GTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVF 591
Query: 539 --------------------SCNIKHTEAPLYV-VDKPVPEESEGPGSPPPYKMIQTIGL 577
C + PL DKPVPEESEGPGSPPPYKMIQTIGL
Sbjct: 592 ITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKDKPVPEESEGPGSPPPYKMIQTIGL 651
Query: 578 SVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEV 637
SVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEV
Sbjct: 652 SVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEV 711
Query: 638 ALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLV 697
ALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLV
Sbjct: 712 ALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLV 771
Query: 698 LVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFL 757
LVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFL
Sbjct: 772 LVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFL 831
Query: 758 RISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVS 817
RISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVS
Sbjct: 832 RISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVS 891
Query: 818 ALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPH 877
ALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPH
Sbjct: 892 ALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPH 951
Query: 878 GGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVD 937
GGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVD
Sbjct: 952 GGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVD 1011
Query: 938 SKP 940
SKP
Sbjct: 1012 SKP 1014
>gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [Homo
sapiens]
Length = 1030
Score = 1134 bits (2933), Expect = 0.0
Identities = 623/926 (67%), Positives = 681/926 (73%), Gaps = 42/926 (4%)
Query: 33 VFIKQPSSQDALQGR-RALLRCEVEA-PGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAV 90
V +K P+S+ +Q + + LRC ++ P P + W DG P+ D + S +
Sbjct: 129 VVLKHPASEAEIQPQTQVTLRCHIDGHPRPTY-QWFRDGTPLSDGQSNHTVSSKERNLTL 187
Query: 91 DRL--QDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTL 148
+ SG + C A G+ S N + +I VVL + + +
Sbjct: 188 RPAGPEHSGLYSCCAHS-AFGQACSSQNFTLSIADESFARVVLA--PQDVVVARYEEAMF 244
Query: 149 RCHIDGHPRPTYQW-FRDGTPLSDGQS----NHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
C P P+ QW F D TP+++ +L L P ++G+Y C
Sbjct: 245 HCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQ 304
Query: 204 SAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDE 263
G + TL +A+ + L V A EE + P PS+ W
Sbjct: 305 GQRGPPIILEA-TLHLAE--IEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEH--- 358
Query: 264 TPITNRSRPPHLRRATVFANG-SLLLTQVRPRNAGIYRCIGQ---GQRGPPI-ILEATLH 318
P H R V+ G L+L + +AG+Y C GQR + I AT+
Sbjct: 359 ---AGVRLPTHGR---VYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVP 412
Query: 319 --LAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGR--VYQKGH 374
L + +D L E G + CL + P+P+V W + + R V++ G
Sbjct: 413 SWLKKPQDSQLEE------GKPGYLDCLT-QATPKPTVVWYRNQMLISEDSRFEVFKNG- 464
Query: 375 ELVLANIAESDAGVYTCHAANLAGQRRQDVNITVANGSSLPEWVTDNAGTLHFARVTRDD 434
L + ++ D Y C ++ AG + V +GSSLPEWVTDNAGTLHFARVTRDD
Sbjct: 465 TLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLDGSSLPEWVTDNAGTLHFARVTRDD 524
Query: 435 AGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQ 494
AGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQ
Sbjct: 525 AGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQ 584
Query: 495 WKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDK 554
WKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDK
Sbjct: 585 WKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDK 644
Query: 555 PVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEP 614
PVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEP
Sbjct: 645 PVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEP 704
Query: 615 EMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGK 674
EMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGK
Sbjct: 705 EMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGK 764
Query: 675 SEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGL 734
SEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGL
Sbjct: 765 SEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGL 824
Query: 735 CREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNN 794
CREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNN
Sbjct: 825 CREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNN 884
Query: 795 RFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFS 854
RFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFS
Sbjct: 885 RFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFS 944
Query: 855 TKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCW 914
TKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCW
Sbjct: 945 TKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCW 1004
Query: 915 ALSPKDRPSFSEIASALGDSTVDSKP 940
ALSPKDRPSFSEIASALGDSTVDSKP
Sbjct: 1005 ALSPKDRPSFSEIASALGDSTVDSKP 1030
Score = 854 bits (2207), Expect = 0.0
Identities = 433/553 (78%), Positives = 453/553 (81%), Gaps = 53/553 (9%)
Query: 1 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP
Sbjct: 1 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
Query: 61 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN
Sbjct: 61 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
Query: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS
Sbjct: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
Query: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE
Sbjct: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
Query: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR
Sbjct: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
Query: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG
Sbjct: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
Query: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVANGSSLPEWVTD 420
VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA ++P W+
Sbjct: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA---TVPSWLK- 416
Query: 421 NAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTAL 480
+P+ + + +G
Sbjct: 417 ----------------------------------------------KPQDSQLEEGKPGY 430
Query: 481 LQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSC 540
L C Q PKP + W ++ R +F+NG+L I+ V D Y C++
Sbjct: 431 LDCLTQATPKPTVVWYRNQMLISEDS---RFEVFKNGTLRINSVEVYDGTWYRCMSSTPA 487
Query: 541 NIKHTEAPLYVVD 553
+A + V+D
Sbjct: 488 GSIEAQARVQVLD 500
Score = 33.9 bits (76), Expect = 0.73
Identities = 31/116 (26%), Positives = 43/116 (37%), Gaps = 19/116 (16%)
Query: 32 IVFIKQPSSQDALQGRRALLRCEVEAPGPVHVYW-----LLDGAPVQDTERRFAQGSSLS 86
I F +P QG ALL+CE + + W +LD + F GS +
Sbjct: 552 ITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVI 611
Query: 87 FAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQP 142
+DSG + C+A + S NIK EA V+ P E P
Sbjct: 612 HDVAP--EDSGRYTCIAGN------------SCNIKHTEAPLYVVDKPVPEESEGP 653
>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo
sapiens]
Length = 1070
Score = 1116 bits (2887), Expect = 0.0
Identities = 624/966 (64%), Positives = 682/966 (70%), Gaps = 82/966 (8%)
Query: 33 VFIKQPSSQDALQGR-RALLRCEVEA-PGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAV 90
V +K P+S+ +Q + + LRC ++ P P + W DG P+ D + S +
Sbjct: 129 VVLKHPASEAEIQPQTQVTLRCHIDGHPRPTY-QWFRDGTPLSDGQSNHTVSSKERNLTL 187
Query: 91 DRL--QDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTL 148
+ SG + C A G+ S N + +I VVL + + +
Sbjct: 188 RPAGPEHSGLYSCCAHS-AFGQACSSQNFTLSIADESFARVVLA--PQDVVVARYEEAMF 244
Query: 149 RCHIDGHPRPTYQW-FRDGTPLSDGQS----NHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
C P P+ QW F D TP+++ +L L P ++G+Y C
Sbjct: 245 HCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQ 304
Query: 204 SAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDE 263
G + TL +A+ + L V A EE + P PS+ W
Sbjct: 305 GQRGPPIILEA-TLHLAE--IEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEH--- 358
Query: 264 TPITNRSRPPHLRRATVFANG-SLLLTQVRPRNAGIYRCIGQ---GQRGPPI-ILEATLH 318
P H R V+ G L+L + +AG+Y C GQR + I AT+
Sbjct: 359 ---AGVRLPTHGR---VYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVP 412
Query: 319 --LAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGR--VYQKGH 374
L + +D L E G + CL + P+P+V W + + R V++ G
Sbjct: 413 SWLKKPQDSQLEE------GKPGYLDCLT-QATPKPTVVWYRNQMLISEDSRFEVFKNG- 464
Query: 375 ELVLANIAESDAGVYTCHAANLAGQRRQDVNITV-------------------------- 408
L + ++ D Y C ++ AG + V
Sbjct: 465 TLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPC 524
Query: 409 --------------ANGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHV 454
A+GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHV
Sbjct: 525 SATGREKPTIKWERADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHV 584
Query: 455 QLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIF 514
QLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIF
Sbjct: 585 QLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIF 644
Query: 515 QNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQT 574
QNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQT
Sbjct: 645 QNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQT 704
Query: 575 IGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQ 634
IGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQ
Sbjct: 705 IGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQ 764
Query: 635 EEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAE 694
EEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAE
Sbjct: 765 EEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAE 824
Query: 695 TLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLK 754
TLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLK
Sbjct: 825 TLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLK 884
Query: 755 QFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQV 814
QFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQV
Sbjct: 885 QFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQV 944
Query: 815 KVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGE 874
KVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGE
Sbjct: 945 KVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGE 1004
Query: 875 MPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDS 934
MPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDS
Sbjct: 1005 MPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDS 1064
Query: 935 TVDSKP 940
TVDSKP
Sbjct: 1065 TVDSKP 1070
Score = 858 bits (2217), Expect = 0.0
Identities = 447/583 (76%), Positives = 464/583 (79%), Gaps = 54/583 (9%)
Query: 1 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP
Sbjct: 1 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
Query: 61 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN
Sbjct: 61 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
Query: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS
Sbjct: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
Query: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE
Sbjct: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
Query: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR
Sbjct: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
Query: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG
Sbjct: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
Query: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVANGSSLPEWVTD 420
VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA ++P W+
Sbjct: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA---TVPSWLKK 417
Query: 421 --------------------------------------------NAGTLHFARVTRDDAG 436
GTL V D
Sbjct: 418 PQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGT 477
Query: 437 NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQ-GHTALLQCEAQGDPKPLIQW 495
Y C++S P G I A ++ V + F P+ + A + C A G KP I+W
Sbjct: 478 WYRCMSST-PAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKW 536
Query: 496 KGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGN 538
+ D P + G+L V +D+G YTCIA N
Sbjct: 537 ERADGSSLPEWVTDNA-----GTLHFARVTRDDAGNYTCIASN 574
Score = 39.7 bits (91), Expect = 0.013
Identities = 41/159 (25%), Positives = 59/159 (37%), Gaps = 27/159 (16%)
Query: 396 LAGQRRQDVNITVANGSSLPEWVTDNAGTLHFARVTR-DDAGNYTCIASNGPQGQ----- 449
L G QD A GSSL FA V R D+G + C+A + G+
Sbjct: 67 LDGAPVQDTERRFAQGSSLS-----------FAAVDRLQDSGTFQCVARDDVTGEEARSA 115
Query: 450 -IRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLG 508
+++ A + K + L+C G P+P QW R P G
Sbjct: 116 NASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQW---FRDGTPLSDG 172
Query: 509 PRMHIF--QNGSLVIHDVAPEDSGRYTCIA----GNSCN 541
H + +L + PE SG Y+C A G +C+
Sbjct: 173 QSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACS 211
Score = 33.9 bits (76), Expect = 0.73
Identities = 31/116 (26%), Positives = 43/116 (37%), Gaps = 19/116 (16%)
Query: 462 ITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVI 521
I F +P QG ALL+CE + + W +LD + F GS +
Sbjct: 32 IVFIKQPSSQDALQGRRALLRCEVEAPGPVHVYW-----LLDGAPVQDTERRFAQGSSLS 86
Query: 522 HDVAP--EDSGRYTCIAGN------------SCNIKHTEAPLYVVDKPVPEESEGP 563
+DSG + C+A + S NIK EA V+ P E P
Sbjct: 87 FAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQP 142
Score = 33.9 bits (76), Expect = 0.73
Identities = 31/116 (26%), Positives = 43/116 (37%), Gaps = 19/116 (16%)
Query: 32 IVFIKQPSSQDALQGRRALLRCEVEAPGPVHVYW-----LLDGAPVQDTERRFAQGSSLS 86
I F +P QG ALL+CE + + W +LD + F GS +
Sbjct: 592 ITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVI 651
Query: 87 FAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQP 142
+DSG + C+A + S NIK EA V+ P E P
Sbjct: 652 HDVAP--EDSGRYTCIAGN------------SCNIKHTEAPLYVVDKPVPEESEGP 693
>gi|222144233 fibroblast growth factor receptor 2 isoform 4
precursor [Homo sapiens]
Length = 709
Score = 230 bits (587), Expect = 4e-60
Identities = 171/637 (26%), Positives = 287/637 (45%), Gaps = 71/637 (11%)
Query: 329 EPRVFTA--GSEERVTCLPPKGLPEPSVW-WEHAGVRLPTHGRVYQKGHELVLANIAESD 385
+P V+ A G V CL L + +V W GV L + R G L + D
Sbjct: 46 QPEVYVAAPGESLEVRCL----LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRD 101
Query: 386 AGVYTCHAANLAGQRRQDVNITVANGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNG 445
+G+Y C A+ + V + S + D D A ++ SN
Sbjct: 102 SGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDT-----------DGAEDFVSENSNN 150
Query: 446 PQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDP 504
+ + + K+E V +T +C A G+P P ++W K
Sbjct: 151 KRAPYWTNTE---------KMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQE 201
Query: 505 TKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSC-NIKHTEAPLYVVDKPVPEESEGP 563
++G Q+ SL++ V P D G YTC+ N +I HT Y +D P +
Sbjct: 202 HRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT----YHLDVVAPGREKEI 257
Query: 564 GSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGG 622
+ P Y I + V ++ V+ C+ K K+P+ +P + L
Sbjct: 258 TASPDYLEIAIYCIGVFLIACMVVTVI--------LCRMKNTTKKPDFSSQPAVHKLTKR 309
Query: 623 PLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD----------------KMHFPRSSL 666
Q + + ++ S T + ST+D K FPR L
Sbjct: 310 IPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKL 369
Query: 667 QPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFGKL 723
LG+ FG+V +A+A G+++ + V V KD+ + D E+EM +
Sbjct: 370 TLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMI 429
Query: 724 N-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD-------EKLKSQPLSTK 775
H N++ LLG C + P Y+++EY G+L+++LR + ++ + ++ K
Sbjct: 430 GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFK 489
Query: 776 QKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FR 834
V+ Q+A GME+L++ + +H+DLAARN LV+ +K++ GL++D+ N +YY
Sbjct: 490 DLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTT 549
Query: 835 QAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKA 894
+P++WM+PEA+ + ++ +SDVW+FGVLMWE+FT G P+ G +E+ L+ G
Sbjct: 550 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH- 608
Query: 895 RLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 931
R+ +P C ++LY +M+ CW P RP+F ++ L
Sbjct: 609 RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 645
Score = 38.5 bits (88), Expect = 0.030
Identities = 43/202 (21%), Positives = 66/202 (32%), Gaps = 36/202 (17%)
Query: 35 IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ 94
I QP A G +RC ++ + W DG + R G L +
Sbjct: 44 ISQPEVYVAAPGESLEVRCLLKDAAVIS--WTKDGVHLGPNNRTVLIGEYLQIKGATP-R 100
Query: 95 DSGTFQCVA------------------------RDDVTGEEARSANASFNIK---WIEAG 127
DSG + C A DD G E + S N + W
Sbjct: 101 DSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE 160
Query: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNL 185
+ + A A V RC G+P PT +W ++G + V ++ +L
Sbjct: 161 KMEKRLHAVPAA----NTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
Query: 186 TLRPAGPEHSGLYSCCAHSAFG 207
+ P G Y+C + +G
Sbjct: 217 IMESVVPSDKGNYTCVVENEYG 238
Score = 34.7 bits (78), Expect = 0.43
Identities = 58/251 (23%), Positives = 91/251 (36%), Gaps = 67/251 (26%)
Query: 132 KHPASEAEIQ---PQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLR 188
K+ S+ E+ P + +RC + W +DG L G +N TV E L ++
Sbjct: 41 KYQISQPEVYVAAPGESLEVRCLLKD--AAVISWTKDGVHL--GPNNRTVLIGEY-LQIK 95
Query: 189 PAGPEHSGLYSCCAHSAFGQACSSQNFTLSIAD--------------ESF----ARVVLA 230
A P SGLY+C A + F +++ D E F + A
Sbjct: 96 GATPRDSGLYACTASRTVDS--ETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153
Query: 231 PQDVVVARYEEAM----------FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPH 274
P + E+ + F C P P+++WL F+ E I + R H
Sbjct: 154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 213
Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFT 334
SL++ V P + G Y C+ + + G + T HL V
Sbjct: 214 ---------WSLIMESVVPSDKGNYTCVVENEYGS---INHTYHL-----------DVVA 250
Query: 335 AGSEERVTCLP 345
G E+ +T P
Sbjct: 251 PGREKEITASP 261
>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform
1 [Homo sapiens]
Length = 790
Score = 226 bits (575), Expect = 1e-58
Identities = 161/536 (30%), Positives = 254/536 (47%), Gaps = 38/536 (7%)
Query: 425 LHFARVTRD-DAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQC 483
L A VT D + N TC A N +++V V ++F + T + H +
Sbjct: 249 LTLANVTSDLNRKNVTCWAENDV-----GRAEVSVQVNVSFPASVQLHTAVEMHHWCIPF 303
Query: 484 EAQGDPKPLIQWKGKDRILDPTK------LGPRMH-IFQNGSLVIHDVAPEDSGRYTCIA 536
G P P ++W +L+ T L P + ++G L ++ ++G YT +A
Sbjct: 304 SVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLA 363
Query: 537 GNSCNIKHTEAPLYVVDKP--------VPEESEGPGSPPPYKMIQTIGLSVGAAVA---- 584
N +D P +P+ + G P K G+SV +A
Sbjct: 364 ANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFAC 423
Query: 585 -YIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLG 643
++ +L ++ C +R K +P PE S+ E + L
Sbjct: 424 LFLSTLLLVLNKCGRRNKFGI--NRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQ 481
Query: 644 SGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQ 703
+ S + H R + LG+ FG+VFLA+ L + LV VK+L+
Sbjct: 482 GHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 541
Query: 704 SKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSK 763
E + DF+RE E+ L H ++VR G+C E P MV EY+ GDL +FLR S
Sbjct: 542 EASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLR-SHGP 600
Query: 764 DEKLKS-------QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKV 816
D KL + PL Q +A+ +QVA GM +L+ FVH+DLA RNCLV VK+
Sbjct: 601 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 660
Query: 817 SALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEM 875
G+S+D+Y+++YY + +P+RWM PE+IL F+T+SDVW+FGV++WE+FT+G+
Sbjct: 661 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQ 720
Query: 876 PHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 931
P ++ E + + G+ L +P CP ++Y +M+ CW P+ R S ++ + L
Sbjct: 721 PWYQLSNTEAIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL 775
Score = 40.0 bits (92), Expect = 0.010
Identities = 49/183 (26%), Positives = 70/183 (38%), Gaps = 33/183 (18%)
Query: 46 GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG--TFQCVA 103
G LLRC+VE G W+L T + SL + D C A
Sbjct: 208 GDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWA 267
Query: 104 RDDV-TGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLR-----CHIDGHPR 157
+DV E + N SF PAS +Q T V + +DG P
Sbjct: 268 ENDVGRAEVSVQVNVSF--------------PAS---VQLHTAVEMHHWCIPFSVDGQPA 310
Query: 158 PTYQWFRDGTPLSDGQSNHT------VSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQA 209
P+ +W +G+ L++ T + R+ LR P H +G Y+ A + FGQA
Sbjct: 311 PSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQA 370
Query: 210 CSS 212
+S
Sbjct: 371 SAS 373
>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform
3 [Homo sapiens]
Length = 760
Score = 226 bits (575), Expect = 1e-58
Identities = 161/536 (30%), Positives = 254/536 (47%), Gaps = 38/536 (7%)
Query: 425 LHFARVTRD-DAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQC 483
L A VT D + N TC A N +++V V ++F + T + H +
Sbjct: 219 LTLANVTSDLNRKNVTCWAENDV-----GRAEVSVQVNVSFPASVQLHTAVEMHHWCIPF 273
Query: 484 EAQGDPKPLIQWKGKDRILDPTK------LGPRMH-IFQNGSLVIHDVAPEDSGRYTCIA 536
G P P ++W +L+ T L P + ++G L ++ ++G YT +A
Sbjct: 274 SVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLA 333
Query: 537 GNSCNIKHTEAPLYVVDKP--------VPEESEGPGSPPPYKMIQTIGLSVGAAVA---- 584
N +D P +P+ + G P K G+SV +A
Sbjct: 334 ANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFAC 393
Query: 585 -YIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLG 643
++ +L ++ C +R K +P PE S+ E + L
Sbjct: 394 LFLSTLLLVLNKCGRRNKFGI--NRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQ 451
Query: 644 SGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQ 703
+ S + H R + LG+ FG+VFLA+ L + LV VK+L+
Sbjct: 452 GHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 511
Query: 704 SKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSK 763
E + DF+RE E+ L H ++VR G+C E P MV EY+ GDL +FLR S
Sbjct: 512 EASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLR-SHGP 570
Query: 764 DEKLKS-------QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKV 816
D KL + PL Q +A+ +QVA GM +L+ FVH+DLA RNCLV VK+
Sbjct: 571 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 630
Query: 817 SALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEM 875
G+S+D+Y+++YY + +P+RWM PE+IL F+T+SDVW+FGV++WE+FT+G+
Sbjct: 631 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQ 690
Query: 876 PHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 931
P ++ E + + G+ L +P CP ++Y +M+ CW P+ R S ++ + L
Sbjct: 691 PWYQLSNTEAIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL 745
Score = 40.0 bits (92), Expect = 0.010
Identities = 49/183 (26%), Positives = 70/183 (38%), Gaps = 33/183 (18%)
Query: 46 GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG--TFQCVA 103
G LLRC+VE G W+L T + SL + D C A
Sbjct: 178 GDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWA 237
Query: 104 RDDV-TGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLR-----CHIDGHPR 157
+DV E + N SF PAS +Q T V + +DG P
Sbjct: 238 ENDVGRAEVSVQVNVSF--------------PAS---VQLHTAVEMHHWCIPFSVDGQPA 280
Query: 158 PTYQWFRDGTPLSDGQSNHT------VSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQA 209
P+ +W +G+ L++ T + R+ LR P H +G Y+ A + FGQA
Sbjct: 281 PSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQA 340
Query: 210 CSS 212
+S
Sbjct: 341 SAS 343
>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform
b precursor [Homo sapiens]
Length = 825
Score = 226 bits (575), Expect = 1e-58
Identities = 181/611 (29%), Positives = 283/611 (46%), Gaps = 70/611 (11%)
Query: 381 IAESDAGVYTCHAANLAGQRRQDVNITVANGSSLP------EWVTDNAGTLHFARVTRDD 434
+ E D V TC N +G DV+ V S+ W +A L VT +D
Sbjct: 221 VREGDNAVITC---NGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSED 277
Query: 435 AG-NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQC---EAQGDPK 490
G TCIA N G A V LTV P ++ + L C +G+P
Sbjct: 278 NGFTLTCIAEN-VVGMSNASVALTVYY------PPRVVSLEEPELRLEHCIEFVVRGNPP 330
Query: 491 PLIQWKGKDRILDPTKLGPRMHI-------FQNGSLVIHDVAPEDSGRYTCIAGNSCNIK 543
P + W + L +K+ +H+ G L+ + ++G YT IA N
Sbjct: 331 PTLHWLHNGQPLRESKI---IHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTA 387
Query: 544 HTEAPLYVVDKPVPEESEG-----PGSPPPYKMI------QTIGLSVG---AAVAYIIAV 589
+ + + +P PE ++ SP P + T G+S+ AA A ++ V
Sbjct: 388 NQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLV 447
Query: 590 LGLMFYCKKRCKAKRLQKQP----EGEEPEMECLNGGPLQNGQPSA-EIQEEVALTSLGS 644
+ + K ++K K P GEE L+ PS+ + + + +
Sbjct: 448 VLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTR 507
Query: 645 GPAATNKRH-STSDKMHFPRSSLQPITT--------LGKSEFGEVFLAKAQGLEEGVAET 695
P N ++ H P + +Q I LG+ FG+VFLA+ L +
Sbjct: 508 IPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKM 567
Query: 696 LVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQ 755
LV VK+L+ + DF+RE E+ L H ++V+ G+C + +P MV EY+ GDL +
Sbjct: 568 LVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNK 627
Query: 756 FLR-------ISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLV 808
FLR I + L Q + + +Q+A GM +L++ FVH+DLA RNCLV
Sbjct: 628 FLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLV 687
Query: 809 SAQRQVKVSALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMW 867
A VK+ G+S+DVY+++YY +P+RWM PE+I+ F+T+SDVW+FGV++W
Sbjct: 688 GANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILW 747
Query: 868 EVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSE- 926
E+FT+G+ P ++ EV+ + G+ L +P CP ++Y +M CW P+ R + E
Sbjct: 748 EIFTYGKQPWFQLSNTEVIECITQGRV-LERPRVCPKEVYDVMLGCWQREPQQRLNIKEI 806
Query: 927 --IASALGDST 935
I ALG +T
Sbjct: 807 YKILHALGKAT 817
Score = 34.3 bits (77), Expect = 0.56
Identities = 39/150 (26%), Positives = 57/150 (38%), Gaps = 22/150 (14%)
Query: 437 NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW- 495
N CI ++G Q + + ++ V TV +G A++ C G P P + W
Sbjct: 186 NLYCINADGSQLPL-FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWI 244
Query: 496 -KGKDRI-LDPTKLG-PRMHIFQNGSLVIHDVAPEDSG-RYTCIAGNSCNIKHTEAPLYV 551
G I T L +H +L + +V ED+G TCIA N + + L V
Sbjct: 245 VTGLQSINTHQTNLNWTNVHAI---NLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTV 301
Query: 552 VDKPVPEESEGP-------------GSPPP 568
P E P G+PPP
Sbjct: 302 YYPPRVVSLEEPELRLEHCIEFVVRGNPPP 331
Score = 33.9 bits (76), Expect = 0.73
Identities = 44/203 (21%), Positives = 72/203 (35%), Gaps = 22/203 (10%)
Query: 215 FTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPH 274
F ++I+ + ++ ++ V + A+ C S P P + W+ I + +
Sbjct: 200 FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSI--NTHQTN 257
Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFT 334
L V A L+ N CI + G + A + + PRV +
Sbjct: 258 LNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVG--------MSNASVALTVYYPPRVVS 309
Query: 335 AGSEE--RVTCLP--PKGLPEPSVWWEHAGVRLP----THGRVYQKGHE----LVLANIA 382
E C+ +G P P++ W H G L H YQ+G L+
Sbjct: 310 LEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPT 369
Query: 383 ESDAGVYTCHAANLAGQRRQDVN 405
+ G YT A N G Q +N
Sbjct: 370 HYNNGNYTLIAKNPLGTANQTIN 392
Score = 31.6 bits (70), Expect = 3.6
Identities = 41/180 (22%), Positives = 75/180 (41%), Gaps = 20/180 (11%)
Query: 45 QGRRALLRCEVEAPGPVHVYWLLDGAP---VQDTERRFAQGSSLSFAAVD-RLQDSG-TF 99
+G A++ C V W++ G T + +++ V+ +D+G T
Sbjct: 223 EGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282
Query: 100 QCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPT 159
C+A ++V G +NAS + + P V+ E ++ + +R G+P PT
Sbjct: 283 TCIA-ENVVG----MSNASVALT-VYYPPRVVSLEEPELRLEHCIEFVVR----GNPPPT 332
Query: 160 YQWFRDGTPLSDGQSNHTVSSKERNLT---LRPAGPEH--SGLYSCCAHSAFGQACSSQN 214
W +G PL + + H +E ++ L P H +G Y+ A + G A + N
Sbjct: 333 LHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTIN 392
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 224 bits (571), Expect = 3e-58
Identities = 169/546 (30%), Positives = 259/546 (47%), Gaps = 59/546 (10%)
Query: 430 VTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVE-----PERTTVYQGHTALLQCE 484
V D GNYTC+ N G IR L V + P T G C+
Sbjct: 218 VVPSDRGNYTCVVEN-KFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCK 276
Query: 485 AQGDPKPLIQWKGKDRILDPTKLGPR----MHIFQNGS----------LVIHDVAPEDSG 530
D +P IQW K ++ +K+GP + + + L +H+V ED+G
Sbjct: 277 VYSDAQPHIQWL-KHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAG 335
Query: 531 RYTCIAGNSCNIKHTEAPLYVVDKPVPEES-EGPGSPPPYKMIQTIGLSVGAAVAYIIAV 589
YTC+AGNS H A L V+ P EE E + Y I LS G I V
Sbjct: 336 EYTCLAGNSIGFSHHSAWLVVL--PAEEELVEADEAGSVYAGI----LSYGVGFFLFILV 389
Query: 590 LGLMFYCKKRCKAKR---------LQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALT 640
+ + C+ R K+ + + P + +E + + + P I A
Sbjct: 390 VAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLE--SNASMSSNTPLVRI----ARL 443
Query: 641 SLGSGPAATNKRH---STSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLV 697
S G GP N K R+ L LG+ FG+V +A+A G+++ A V
Sbjct: 444 SSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPV 503
Query: 698 LVKSLQSKDEQQQLDFR---RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDL 753
V KD+ D E+EM + H N++ LLG C + P Y+++EY G+L
Sbjct: 504 TVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNL 563
Query: 754 KQFLRISK------SKDE-KLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNC 806
++FLR + S D K + L+ K V+ QVA GME+L++ + +H+DLAARN
Sbjct: 564 REFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNV 623
Query: 807 LVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVL 865
LV+ +K++ GL++DV+N +YY +P++WM+PEA+ + ++ +SDVW+FGVL
Sbjct: 624 LVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 683
Query: 866 MWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFS 925
+WE+FT G P+ G +E+ L+ G R+ +P C LY +M+ CW +P RP+F
Sbjct: 684 LWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPANCTHDLYMIMRECWHAAPSQRPTFK 742
Query: 926 EIASAL 931
++ L
Sbjct: 743 QLVEDL 748
Score = 55.8 bits (133), Expect = 2e-07
Identities = 72/278 (25%), Positives = 102/278 (36%), Gaps = 57/278 (20%)
Query: 329 EPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGV 388
E VF +G ++C PP G P W G L RV L + N + D+G
Sbjct: 47 EQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGA 106
Query: 389 YTCHAANLAGQRRQDVNITVANGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQG 448
Y+C L + ++ V + S + D G +D T + + P
Sbjct: 107 YSCRQ-RLTQRVLCHFSVRVTDAPSSGD---DEDG---------EDEAEDTGVDTGAP-- 151
Query: 449 QIRAHVQLTVAVFITFKVEPERT-----TVYQGHTALLQCEAQGDPKPLIQW-KGKDRIL 502
+ PER V +T +C A G+P P I W K
Sbjct: 152 ---------------YWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFR 196
Query: 503 DPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSC-NIKHTEAPLYVVDKPVPEESE 561
++G Q SLV+ V P D G YTC+ N +I+ T Y +D V E S
Sbjct: 197 GEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT----YTLD--VLERS- 249
Query: 562 GPGSPPPYKMIQTIGLSVGAAVAYIIAVLG--LMFYCK 597
P++ I GL AVLG + F+CK
Sbjct: 250 ------PHRPILQAGLPANQT-----AVLGSDVEFHCK 276
Score = 53.5 bits (127), Expect = 9e-07
Identities = 55/259 (21%), Positives = 90/259 (34%), Gaps = 48/259 (18%)
Query: 37 QPSSQDAL---QGRRALLRCEVEAPGPVH-VYWLLDGAPVQDTERRFAQGSSLSFAAVDR 92
+P Q+ L G L C GP+ W+ DG + +ER L
Sbjct: 42 EPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASH 101
Query: 93 LQDSGTFQCVAR--------------------DDVTGEEARSANASFNIKWIEAGPVVLK 132
+DSG + C R DD GE+ ++ G
Sbjct: 102 -EDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTG------VDTGAPYWT 154
Query: 133 HPASEAE----IQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS-----KER 183
P + + V RC G+P P+ W ++G + + H + ++
Sbjct: 155 RPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNG---REFRGEHRIGGIKLRHQQW 211
Query: 184 NLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYE 240
+L + P G Y+C + FG Q +TL + + S R +L P +
Sbjct: 212 SLVMESVVPSDRGNYTCVVENKFGSI--RQTYTLDVLERSPHRPILQAGLPANQTAVLGS 269
Query: 241 EAMFHCQFSAQPPPSLQWL 259
+ FHC+ + P +QWL
Sbjct: 270 DVEFHCKVYSDAQPHIQWL 288
Score = 34.7 bits (78), Expect = 0.43
Identities = 66/294 (22%), Positives = 97/294 (32%), Gaps = 62/294 (21%)
Query: 154 GHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQ 213
G P W +DGT L + V + L + A E SG YSC C
Sbjct: 66 GGPMGPTVWVKDGTGLVPSER---VLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLC--- 119
Query: 214 NFTLSIAD-------------------ESFARVVLAPQDV-----VVARYEEAMFHCQFS 249
+F++ + D ++ A P+ + V F C +
Sbjct: 120 HFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAA 179
Query: 250 AQPPPSLQWLFED-ETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRG 308
P PS+ WL E +R LR SL++ V P + G Y C+ + + G
Sbjct: 180 GNPTPSISWLKNGREFRGEHRIGGIKLRHQ----QWSLVMESVVPSDRGNYTCVVENKFG 235
Query: 309 PPIILEATLHLAEIEDMP--------LFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHA- 359
+ T L +E P L + GS+ C W +H
Sbjct: 236 S---IRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVE 292
Query: 360 --GVRLPTHGRVY-------------QKGHELVLANIAESDAGVYTCHAANLAG 398
G ++ G Y ++ L L N+ DAG YTC A N G
Sbjct: 293 VNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIG 346
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 223 bits (568), Expect = 7e-58
Identities = 187/640 (29%), Positives = 285/640 (44%), Gaps = 87/640 (13%)
Query: 329 EPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGV 388
E VF +G ++C PP G P W G L RV L + N + D+G
Sbjct: 47 EQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGA 106
Query: 389 YTCHAANLAGQRRQDVNITVANGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQG 448
Y+C L + ++ V + S + D G +D T + + P
Sbjct: 107 YSCRQ-RLTQRVLCHFSVRVTDAPSSGD---DEDG---------EDEAEDTGVDTGAP-- 151
Query: 449 QIRAHVQLTVAVFITFKVEPERT-----TVYQGHTALLQCEAQGDPKPLIQW-KGKDRIL 502
+ PER V +T +C A G+P P I W K
Sbjct: 152 ---------------YWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFR 196
Query: 503 DPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSC-NIKHTEAPLYVVDKPVPEESE 561
++G Q SLV+ V P D G YTC+ N +I+ T Y +D V E S
Sbjct: 197 GEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT----YTLD--VLERS- 249
Query: 562 GPGSPPPYKMIQTIGLSVGAAVAYIIAVLG--LMFYCK------------KRCKAKRLQK 607
P++ I GL AVLG + F+CK K + +
Sbjct: 250 ------PHRPILQAGLPANQT-----AVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKV 298
Query: 608 QPEGEEPEMECLNGGPLQNGQPSAEIQ-EEVALTSLGSGPAATNKRH---STSDKMHFPR 663
P+G P + L N S+ +A S G GP N K R
Sbjct: 299 GPDGT-PYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSR 357
Query: 664 SSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMF 720
+ L LG+ FG+V +A+A G+++ A V V KD+ D E+EM
Sbjct: 358 ARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM 417
Query: 721 GKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISK------SKDE-KLKSQPL 772
+ H N++ LLG C + P Y+++EY G+L++FLR + S D K + L
Sbjct: 418 KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQL 477
Query: 773 STKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYY- 831
+ K V+ QVA GME+L++ + +H+DLAARN LV+ +K++ GL++DV+N +YY
Sbjct: 478 TFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYK 537
Query: 832 HFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQA 891
+P++WM+PEA+ + ++ +SDVW+FGVL+WE+FT G P+ G +E+ L+
Sbjct: 538 KTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE 597
Query: 892 GKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 931
G R+ +P C LY +M+ CW +P RP+F ++ L
Sbjct: 598 GH-RMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL 636
Score = 53.5 bits (127), Expect = 9e-07
Identities = 55/259 (21%), Positives = 90/259 (34%), Gaps = 48/259 (18%)
Query: 37 QPSSQDAL---QGRRALLRCEVEAPGPVH-VYWLLDGAPVQDTERRFAQGSSLSFAAVDR 92
+P Q+ L G L C GP+ W+ DG + +ER L
Sbjct: 42 EPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASH 101
Query: 93 LQDSGTFQCVAR--------------------DDVTGEEARSANASFNIKWIEAGPVVLK 132
+DSG + C R DD GE+ ++ G
Sbjct: 102 -EDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTG------VDTGAPYWT 154
Query: 133 HPASEAE----IQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS-----KER 183
P + + V RC G+P P+ W ++G + + H + ++
Sbjct: 155 RPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNG---REFRGEHRIGGIKLRHQQW 211
Query: 184 NLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYE 240
+L + P G Y+C + FG Q +TL + + S R +L P +
Sbjct: 212 SLVMESVVPSDRGNYTCVVENKFGSI--RQTYTLDVLERSPHRPILQAGLPANQTAVLGS 269
Query: 241 EAMFHCQFSAQPPPSLQWL 259
+ FHC+ + P +QWL
Sbjct: 270 DVEFHCKVYSDAQPHIQWL 288
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 223 bits (567), Expect = 9e-58
Identities = 168/548 (30%), Positives = 267/548 (48%), Gaps = 59/548 (10%)
Query: 430 VTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVE-----PERTTVYQGHTALLQCE 484
V D GNYTCI N G I QL V + P TV G C+
Sbjct: 129 VVPSDKGNYTCIVEN-EYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCK 187
Query: 485 AQGDPKPLIQWKGKDRILDPTKLGPR----MHIFQNGSL--------VIH--DVAPEDSG 530
DP+P IQW K ++ +K+GP + I + + V+H +V+ ED+G
Sbjct: 188 VYSDPQPHIQWL-KHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAG 246
Query: 531 RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQT-------IGLSVGAAV 583
YTC+AGNS + H A L V++ EE + P Y I I VG+ +
Sbjct: 247 EYTCLAGNSIGLSHHSAWLTVLE--ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVI 304
Query: 584 AYII------AVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEV 637
Y + + K K+ L++Q +N G L +
Sbjct: 305 VYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVL--------LVRPS 356
Query: 638 ALTSLGSGPAATNKRHSTSD--KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAE- 694
L+S G+ A + + + PR L LG+ FG+V LA+A GL++
Sbjct: 357 RLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNR 416
Query: 695 -TLVLVKSLQSKDEQQQL-DFRRELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLG 751
T V VK L+S ++ L D E+EM + H N++ LLG C + P Y+++EY G
Sbjct: 417 VTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG 476
Query: 752 DLKQFLRISKSKDEKLKSQP-------LSTKQKVALCTQVALGMEHLSNNRFVHKDLAAR 804
+L+++L+ + + P LS+K V+ QVA GME+L++ + +H+DLAAR
Sbjct: 477 NLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAAR 536
Query: 805 NCLVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWVPLRWMSPEAILEGDFSTKSDVWAFG 863
N LV+ +K++ GL++D+++ +YY +P++WM+PEA+ + ++ +SDVW+FG
Sbjct: 537 NVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFG 596
Query: 864 VLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPS 923
VL+WE+FT G P+ G +E+ L+ G R+ +P C ++LY +M+ CW P RP+
Sbjct: 597 VLLWEIFTLGGSPYPGVPVEELFKLLKEGH-RMDKPSNCTNELYMMMRDCWHAVPSQRPT 655
Query: 924 FSEIASAL 931
F ++ L
Sbjct: 656 FKQLVEDL 663
Score = 46.2 bits (108), Expect = 1e-04
Identities = 28/119 (23%), Positives = 48/119 (40%), Gaps = 7/119 (5%)
Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
V +C G P PT +W ++G + V ++ + P G Y+C
Sbjct: 83 VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE 142
Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
+ +G + + L + + S R +L P + VA F C+ + P P +QWL
Sbjct: 143 NEYGSI--NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWL 199
Score = 44.7 bits (104), Expect = 4e-04
Identities = 35/122 (28%), Positives = 52/122 (42%), Gaps = 15/122 (12%)
Query: 465 KVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPT-KLGPRMHIFQNGSLVIHD 523
K+E + V T +C + G P P ++W + P ++G + S+++
Sbjct: 69 KMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDS 128
Query: 524 VAPEDSGRYTCIAGNSC-NIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAA 582
V P D G YTCI N +I HT Y +D V E S P++ I GL
Sbjct: 129 VVPSDKGNYTCIVENEYGSINHT----YQLD--VVERS-------PHRPILQAGLPANKT 175
Query: 583 VA 584
VA
Sbjct: 176 VA 177
Score = 40.8 bits (94), Expect = 0.006
Identities = 50/192 (26%), Positives = 72/192 (37%), Gaps = 36/192 (18%)
Query: 244 FHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRA--TVFANGSLLLTQVRPRNAGIYRC 301
F C S P P+L+WL + +P H +A S+++ V P + G Y C
Sbjct: 85 FKCPSSGTPNPTLRWLKNGK-----EFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTC 139
Query: 302 IGQGQRGPPIILEATLHLAEIEDMP--------LFEPRVFTAGSEERVTCLPPKGLPEPS 353
I + + G + T L +E P L + GS C P+P
Sbjct: 140 IVENEYGS---INHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD-PQPH 195
Query: 354 VWW-EHAGVR--------------LPTHG-RVYQKGHELV-LANIAESDAGVYTCHAANL 396
+ W +H V L T G K E++ L N++ DAG YTC A N
Sbjct: 196 IQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNS 255
Query: 397 AGQRRQDVNITV 408
G +TV
Sbjct: 256 IGLSHHSAWLTV 267
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 223 bits (567), Expect = 9e-58
Identities = 168/548 (30%), Positives = 267/548 (48%), Gaps = 59/548 (10%)
Query: 430 VTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVE-----PERTTVYQGHTALLQCE 484
V D GNYTCI N G I QL V + P TV G C+
Sbjct: 131 VVPSDKGNYTCIVEN-EYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCK 189
Query: 485 AQGDPKPLIQWKGKDRILDPTKLGPR----MHIFQNGSL--------VIH--DVAPEDSG 530
DP+P IQW K ++ +K+GP + I + + V+H +V+ ED+G
Sbjct: 190 VYSDPQPHIQWL-KHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAG 248
Query: 531 RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQT-------IGLSVGAAV 583
YTC+AGNS + H A L V++ EE + P Y I I VG+ +
Sbjct: 249 EYTCLAGNSIGLSHHSAWLTVLE--ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVI 306
Query: 584 AYII------AVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEV 637
Y + + K K+ L++Q +N G L +
Sbjct: 307 VYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVL--------LVRPS 358
Query: 638 ALTSLGSGPAATNKRHSTSD--KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAE- 694
L+S G+ A + + + PR L LG+ FG+V LA+A GL++
Sbjct: 359 RLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNR 418
Query: 695 -TLVLVKSLQSKDEQQQL-DFRRELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLG 751
T V VK L+S ++ L D E+EM + H N++ LLG C + P Y+++EY G
Sbjct: 419 VTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG 478
Query: 752 DLKQFLRISKSKDEKLKSQP-------LSTKQKVALCTQVALGMEHLSNNRFVHKDLAAR 804
+L+++L+ + + P LS+K V+ QVA GME+L++ + +H+DLAAR
Sbjct: 479 NLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAAR 538
Query: 805 NCLVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWVPLRWMSPEAILEGDFSTKSDVWAFG 863
N LV+ +K++ GL++D+++ +YY +P++WM+PEA+ + ++ +SDVW+FG
Sbjct: 539 NVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFG 598
Query: 864 VLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPS 923
VL+WE+FT G P+ G +E+ L+ G R+ +P C ++LY +M+ CW P RP+
Sbjct: 599 VLLWEIFTLGGSPYPGVPVEELFKLLKEGH-RMDKPSNCTNELYMMMRDCWHAVPSQRPT 657
Query: 924 FSEIASAL 931
F ++ L
Sbjct: 658 FKQLVEDL 665
Score = 46.2 bits (108), Expect = 1e-04
Identities = 28/119 (23%), Positives = 48/119 (40%), Gaps = 7/119 (5%)
Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
V +C G P PT +W ++G + V ++ + P G Y+C
Sbjct: 85 VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE 144
Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
+ +G + + L + + S R +L P + VA F C+ + P P +QWL
Sbjct: 145 NEYGSI--NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWL 201
Score = 44.7 bits (104), Expect = 4e-04
Identities = 35/122 (28%), Positives = 52/122 (42%), Gaps = 15/122 (12%)
Query: 465 KVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPT-KLGPRMHIFQNGSLVIHD 523
K+E + V T +C + G P P ++W + P ++G + S+++
Sbjct: 71 KMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDS 130
Query: 524 VAPEDSGRYTCIAGNSC-NIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAA 582
V P D G YTCI N +I HT Y +D V E S P++ I GL
Sbjct: 131 VVPSDKGNYTCIVENEYGSINHT----YQLD--VVERS-------PHRPILQAGLPANKT 177
Query: 583 VA 584
VA
Sbjct: 178 VA 179
Score = 40.8 bits (94), Expect = 0.006
Identities = 50/192 (26%), Positives = 72/192 (37%), Gaps = 36/192 (18%)
Query: 244 FHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRA--TVFANGSLLLTQVRPRNAGIYRC 301
F C S P P+L+WL + +P H +A S+++ V P + G Y C
Sbjct: 87 FKCPSSGTPNPTLRWLKNGK-----EFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTC 141
Query: 302 IGQGQRGPPIILEATLHLAEIEDMP--------LFEPRVFTAGSEERVTCLPPKGLPEPS 353
I + + G + T L +E P L + GS C P+P
Sbjct: 142 IVENEYGS---INHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD-PQPH 197
Query: 354 VWW-EHAGVR--------------LPTHG-RVYQKGHELV-LANIAESDAGVYTCHAANL 396
+ W +H V L T G K E++ L N++ DAG YTC A N
Sbjct: 198 IQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNS 257
Query: 397 AGQRRQDVNITV 408
G +TV
Sbjct: 258 IGLSHHSAWLTV 269
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 223 bits (567), Expect = 9e-58
Identities = 168/548 (30%), Positives = 267/548 (48%), Gaps = 59/548 (10%)
Query: 430 VTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVE-----PERTTVYQGHTALLQCE 484
V D GNYTCI N G I QL V + P TV G C+
Sbjct: 218 VVPSDKGNYTCIVEN-EYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCK 276
Query: 485 AQGDPKPLIQWKGKDRILDPTKLGPR----MHIFQNGSL--------VIH--DVAPEDSG 530
DP+P IQW K ++ +K+GP + I + + V+H +V+ ED+G
Sbjct: 277 VYSDPQPHIQWL-KHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAG 335
Query: 531 RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQT-------IGLSVGAAV 583
YTC+AGNS + H A L V++ EE + P Y I I VG+ +
Sbjct: 336 EYTCLAGNSIGLSHHSAWLTVLE--ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVI 393
Query: 584 AYII------AVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEV 637
Y + + K K+ L++Q +N G L +
Sbjct: 394 VYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVL--------LVRPS 445
Query: 638 ALTSLGSGPAATNKRHSTSD--KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAE- 694
L+S G+ A + + + PR L LG+ FG+V LA+A GL++
Sbjct: 446 RLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNR 505
Query: 695 -TLVLVKSLQSKDEQQQL-DFRRELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLG 751
T V VK L+S ++ L D E+EM + H N++ LLG C + P Y+++EY G
Sbjct: 506 VTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG 565
Query: 752 DLKQFLRISKSKDEKLKSQP-------LSTKQKVALCTQVALGMEHLSNNRFVHKDLAAR 804
+L+++L+ + + P LS+K V+ QVA GME+L++ + +H+DLAAR
Sbjct: 566 NLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAAR 625
Query: 805 NCLVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWVPLRWMSPEAILEGDFSTKSDVWAFG 863
N LV+ +K++ GL++D+++ +YY +P++WM+PEA+ + ++ +SDVW+FG
Sbjct: 626 NVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFG 685
Query: 864 VLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPS 923
VL+WE+FT G P+ G +E+ L+ G R+ +P C ++LY +M+ CW P RP+
Sbjct: 686 VLLWEIFTLGGSPYPGVPVEELFKLLKEGH-RMDKPSNCTNELYMMMRDCWHAVPSQRPT 744
Query: 924 FSEIASAL 931
F ++ L
Sbjct: 745 FKQLVEDL 752
Score = 55.8 bits (133), Expect = 2e-07
Identities = 54/234 (23%), Positives = 91/234 (38%), Gaps = 32/234 (13%)
Query: 353 SVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVANGS 412
S+ W GV+L R G E+ + + +D+G+Y C ++ +G ++ V++
Sbjct: 63 SINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDAL 122
Query: 413 SLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTT 472
E D+ + + T + N P+ K+E +
Sbjct: 123 PSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPE-----------------KMEKKLHA 165
Query: 473 VYQGHTALLQCEAQGDPKPLIQWKGKDRILDPT-KLGPRMHIFQNGSLVIHDVAPEDSGR 531
V T +C + G P P ++W + P ++G + S+++ V P D G
Sbjct: 166 VPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGN 225
Query: 532 YTCIAGNSC-NIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVA 584
YTCI N +I HT Y +D V E S P++ I GL VA
Sbjct: 226 YTCIVENEYGSINHT----YQLD--VVERS-------PHRPILQAGLPANKTVA 266
Score = 50.8 bits (120), Expect = 6e-06
Identities = 76/327 (23%), Positives = 121/327 (37%), Gaps = 73/327 (22%)
Query: 140 IQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYS 199
+ P + LRC + + + W RDG L++ SN T + E + ++ + P SGLY+
Sbjct: 45 VHPGDLLQLRCRLRDDVQ-SINWLRDGVQLAE--SNRTRITGEE-VEVQDSVPADSGLYA 100
Query: 200 CCAHSAFGQACSSQNFTLSIAD--------------------------ESFARVVLAPQD 233
C S G + F+++++D A +P+
Sbjct: 101 CVTSSPSGS--DTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEK 158
Query: 234 V-----VVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRA--TVFANGSL 286
+ V + F C S P P+L+WL + +P H +A S+
Sbjct: 159 MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGK-----EFKPDHRIGGYKVRYATWSI 213
Query: 287 LLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP--------LFEPRVFTAGSE 338
++ V P + G Y CI + + G + T L +E P L + GS
Sbjct: 214 IMDSVVPSDKGNYTCIVENEYGS---INHTYQLDVVERSPHRPILQAGLPANKTVALGSN 270
Query: 339 ERVTCLPPKGLPEPSVWW-EHAGVR--------------LPTHG-RVYQKGHELV-LANI 381
C P+P + W +H V L T G K E++ L N+
Sbjct: 271 VEFMCKVYSD-PQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 329
Query: 382 AESDAGVYTCHAANLAGQRRQDVNITV 408
+ DAG YTC A N G +TV
Sbjct: 330 SFEDAGEYTCLAGNSIGLSHHSAWLTV 356
Score = 47.4 bits (111), Expect = 6e-05
Identities = 54/248 (21%), Positives = 87/248 (35%), Gaps = 49/248 (19%)
Query: 48 RALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ-DSGTFQCVAR-- 104
R LR +V++ + WL DG + ++ R G + D + DSG + CV
Sbjct: 54 RCRLRDDVQS-----INWLRDGVQLAESNRTRITGEEVEVQ--DSVPADSGLYACVTSSP 106
Query: 105 -------------------------DDVTGEEARSANASFNIK---WIEAGPVVLKHPAS 136
DD + EE + N N W + K A
Sbjct: 107 SGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAV 166
Query: 137 EAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEH 194
A V +C G P PT +W ++G + V ++ + P
Sbjct: 167 PAA----KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSD 222
Query: 195 SGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQ 251
G Y+C + +G + + L + + S R +L P + VA F C+ +
Sbjct: 223 KGNYTCIVENEYGSI--NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 280
Query: 252 PPPSLQWL 259
P P +QWL
Sbjct: 281 PQPHIQWL 288
>gi|105990522 fibroblast growth factor receptor 1 isoform 1
precursor [Homo sapiens]
Length = 822
Score = 223 bits (567), Expect = 9e-58
Identities = 168/548 (30%), Positives = 267/548 (48%), Gaps = 59/548 (10%)
Query: 430 VTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVE-----PERTTVYQGHTALLQCE 484
V D GNYTCI N G I QL V + P TV G C+
Sbjct: 220 VVPSDKGNYTCIVEN-EYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCK 278
Query: 485 AQGDPKPLIQWKGKDRILDPTKLGPR----MHIFQNGSL--------VIH--DVAPEDSG 530
DP+P IQW K ++ +K+GP + I + + V+H +V+ ED+G
Sbjct: 279 VYSDPQPHIQWL-KHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAG 337
Query: 531 RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQT-------IGLSVGAAV 583
YTC+AGNS + H A L V++ EE + P Y I I VG+ +
Sbjct: 338 EYTCLAGNSIGLSHHSAWLTVLE--ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVI 395
Query: 584 AYII------AVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEV 637
Y + + K K+ L++Q +N G L +
Sbjct: 396 VYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVL--------LVRPS 447
Query: 638 ALTSLGSGPAATNKRHSTSD--KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAE- 694
L+S G+ A + + + PR L LG+ FG+V LA+A GL++
Sbjct: 448 RLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNR 507
Query: 695 -TLVLVKSLQSKDEQQQL-DFRRELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLG 751
T V VK L+S ++ L D E+EM + H N++ LLG C + P Y+++EY G
Sbjct: 508 VTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG 567
Query: 752 DLKQFLRISKSKDEKLKSQP-------LSTKQKVALCTQVALGMEHLSNNRFVHKDLAAR 804
+L+++L+ + + P LS+K V+ QVA GME+L++ + +H+DLAAR
Sbjct: 568 NLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAAR 627
Query: 805 NCLVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWVPLRWMSPEAILEGDFSTKSDVWAFG 863
N LV+ +K++ GL++D+++ +YY +P++WM+PEA+ + ++ +SDVW+FG
Sbjct: 628 NVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFG 687
Query: 864 VLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPS 923
VL+WE+FT G P+ G +E+ L+ G R+ +P C ++LY +M+ CW P RP+
Sbjct: 688 VLLWEIFTLGGSPYPGVPVEELFKLLKEGH-RMDKPSNCTNELYMMMRDCWHAVPSQRPT 746
Query: 924 FSEIASAL 931
F ++ L
Sbjct: 747 FKQLVEDL 754
Score = 55.8 bits (133), Expect = 2e-07
Identities = 56/236 (23%), Positives = 95/236 (40%), Gaps = 34/236 (14%)
Query: 353 SVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVANGS 412
S+ W GV+L R G E+ + + +D+G+Y C ++ +G ++ V++
Sbjct: 63 SINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDAL 122
Query: 413 SLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITF--KVEPER 470
E D+ + + T + N ++ VA + T K+E +
Sbjct: 123 PSSEDDDDDDDSSSEEKETDNTKPN-----------------RMPVAPYWTSPEKMEKKL 165
Query: 471 TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPT-KLGPRMHIFQNGSLVIHDVAPEDS 529
V T +C + G P P ++W + P ++G + S+++ V P D
Sbjct: 166 HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 225
Query: 530 GRYTCIAGNSC-NIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVA 584
G YTCI N +I HT Y +D V E S P++ I GL VA
Sbjct: 226 GNYTCIVENEYGSINHT----YQLD--VVERS-------PHRPILQAGLPANKTVA 268
Score = 52.8 bits (125), Expect = 2e-06
Identities = 79/327 (24%), Positives = 124/327 (37%), Gaps = 71/327 (21%)
Query: 140 IQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYS 199
+ P + LRC + + + W RDG L++ SN T + E + ++ + P SGLY+
Sbjct: 45 VHPGDLLQLRCRLRDDVQ-SINWLRDGVQLAE--SNRTRITGEE-VEVQDSVPADSGLYA 100
Query: 200 CCAHSAFGQACSSQNFTLSIA----------DESFA-----------RVVLAPQDVVVAR 238
C S G + + +S A D+S + R+ +AP +
Sbjct: 101 CVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEK 160
Query: 239 YEEAM----------FHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRA--TVFANGSL 286
E+ + F C S P P+L+WL + +P H +A S+
Sbjct: 161 MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGK-----EFKPDHRIGGYKVRYATWSI 215
Query: 287 LLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP--------LFEPRVFTAGSE 338
++ V P + G Y CI + + G + T L +E P L + GS
Sbjct: 216 IMDSVVPSDKGNYTCIVENEYGS---INHTYQLDVVERSPHRPILQAGLPANKTVALGSN 272
Query: 339 ERVTCLPPKGLPEPSVWW-EHAGVR--------------LPTHG-RVYQKGHELV-LANI 381
C P+P + W +H V L T G K E++ L N+
Sbjct: 273 VEFMCKVYSD-PQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 331
Query: 382 AESDAGVYTCHAANLAGQRRQDVNITV 408
+ DAG YTC A N G +TV
Sbjct: 332 SFEDAGEYTCLAGNSIGLSHHSAWLTV 358
Score = 47.0 bits (110), Expect = 8e-05
Identities = 51/246 (20%), Positives = 87/246 (35%), Gaps = 43/246 (17%)
Query: 48 RALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ-DSGTFQCVAR-- 104
R LR +V++ + WL DG + ++ R G + D + DSG + CV
Sbjct: 54 RCRLRDDVQS-----INWLRDGVQLAESNRTRITGEEVEVQ--DSVPADSGLYACVTSSP 106
Query: 105 -------------------------DDVTGEEARSANASFNIKWIEAGPVVLKHPASEAE 139
DD + EE + N N + + +
Sbjct: 107 SGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLH 166
Query: 140 IQPQTQ-VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSG 196
P + V +C G P PT +W ++G + V ++ + P G
Sbjct: 167 AVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKG 226
Query: 197 LYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPP 253
Y+C + +G + + L + + S R +L P + VA F C+ + P
Sbjct: 227 NYTCIVENEYGSI--NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQ 284
Query: 254 PSLQWL 259
P +QWL
Sbjct: 285 PHIQWL 290
>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
[Homo sapiens]
Length = 796
Score = 222 bits (565), Expect = 1e-57
Identities = 162/542 (29%), Positives = 252/542 (46%), Gaps = 44/542 (8%)
Query: 425 LHFARVTRD-DAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQC 483
L A VT D + N TC A N +++V V ++F + T + H +
Sbjct: 249 LTLANVTSDLNRKNVTCWAENDV-----GRAEVSVQVNVSFPASVQLHTAVEMHHWCIPF 303
Query: 484 EAQGDPKPLIQWKGKDRILDPTK------LGPRMH-IFQNGSLVIHDVAPEDSGRYTCIA 536
G P P ++W +L+ T L P + ++G L ++ ++G YT +A
Sbjct: 304 SVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLA 363
Query: 537 GNSCNIKHTEAPLYVVDKPVPEESEGP--------------GSPPPYKMIQTIGLSVGAA 582
N +D P E P G P K G+SV
Sbjct: 364 ANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVG 423
Query: 583 VA-----YIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEV 637
+A ++ +L ++ C +R K +P PE S+ E
Sbjct: 424 LAVFACLFLSTLLLVLNKCGRRNKFGI--NRPAVLAPEDGLAMSLHFMTLGGSSLSPTEG 481
Query: 638 ALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLV 697
+ L + S + H R + LG+ FG+VFLA+ L + LV
Sbjct: 482 KGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLV 541
Query: 698 LVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFL 757
VK+L+ E + DF+RE E+ L H ++VR G+C E P MV EY+ GDL +FL
Sbjct: 542 AVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFL 601
Query: 758 RISKSKDEKLKS-------QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSA 810
R S D KL + PL Q +A+ +QVA GM +L+ FVH+DLA RNCLV
Sbjct: 602 R-SHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ 660
Query: 811 QRQVKVSALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEV 869
VK+ G+S+D+Y+++YY + +P+RWM PE+IL F+T+SDVW+FGV++WE+
Sbjct: 661 GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI 720
Query: 870 FTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIAS 929
FT+G+ P ++ E + + G+ L +P CP ++Y +M+ CW P+ R S ++ +
Sbjct: 721 FTYGKQPWYQLSNTEAIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHA 779
Query: 930 AL 931
L
Sbjct: 780 RL 781
Score = 40.0 bits (92), Expect = 0.010
Identities = 49/183 (26%), Positives = 70/183 (38%), Gaps = 33/183 (18%)
Query: 46 GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG--TFQCVA 103
G LLRC+VE G W+L T + SL + D C A
Sbjct: 208 GDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWA 267
Query: 104 RDDV-TGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLR-----CHIDGHPR 157
+DV E + N SF PAS +Q T V + +DG P
Sbjct: 268 ENDVGRAEVSVQVNVSF--------------PAS---VQLHTAVEMHHWCIPFSVDGQPA 310
Query: 158 PTYQWFRDGTPLSDGQSNHT------VSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQA 209
P+ +W +G+ L++ T + R+ LR P H +G Y+ A + FGQA
Sbjct: 311 PSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQA 370
Query: 210 CSS 212
+S
Sbjct: 371 SAS 373
>gi|222144239 fibroblast growth factor receptor 2 isoform 7
precursor [Homo sapiens]
Length = 705
Score = 222 bits (565), Expect = 1e-57
Identities = 175/639 (27%), Positives = 291/639 (45%), Gaps = 79/639 (12%)
Query: 329 EPRVFTA--GSEERVTCLPPKGLPEPSVW-WEHAGVRLPTHGRVYQKGHELVLANIAESD 385
+P V+ A G V CL L + +V W GV L + R G L + D
Sbjct: 46 QPEVYVAAPGESLEVRCL----LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRD 101
Query: 386 AGVYTCHAANLAGQRRQDVNITVANGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNG 445
+G+Y C A+ + V + S + D D A ++ SN
Sbjct: 102 SGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDT-----------DGAEDFVSENSNN 150
Query: 446 PQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDP 504
+ + + K+E V +T +C A G+P P ++W K
Sbjct: 151 KRAPYWTNTE---------KMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQE 201
Query: 505 TKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSC-NIKHTEAPLYVVDKPVPEESEGP 563
++G Q+ SL++ V P D G YTC+ N +I HT Y +D V E S
Sbjct: 202 HRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT----YHLD--VVERS--- 252
Query: 564 GSPPPYKMIQTIGLSVGAAVAYIIAVLG--LMFYCKKRCKA-------KRLQKQPEGEEP 614
P++ I GL A+ V+G + F CK A K ++K P
Sbjct: 253 ----PHRPILQAGLPANAST-----VVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGP 303
Query: 615 E---------MECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD-KMHFPRS 664
+ + + + + P I ++ T+ A ++ D K FPR
Sbjct: 304 DGLPYLKVLKVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD 363
Query: 665 SLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFG 721
L LG+ FG+V +A+A G+++ + V V KD+ + D E+EM
Sbjct: 364 KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK 423
Query: 722 KLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD-------EKLKSQPLS 773
+ H N++ LLG C + P Y+++EY G+L+++LR + ++ + ++
Sbjct: 424 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT 483
Query: 774 TKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH- 832
K V+ Q+A GME+L++ + +H+DLAARN LV+ +K++ GL++D+ N +YY
Sbjct: 484 FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK 543
Query: 833 FRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAG 892
+P++WM+PEA+ + ++ +SDVW+FGVLMWE+FT G P+ G +E+ L+ G
Sbjct: 544 TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG 603
Query: 893 KARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 931
R+ +P C ++LY +M+ CW P RP+F ++ L
Sbjct: 604 H-RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 641
Score = 47.0 bits (110), Expect = 8e-05
Identities = 53/257 (20%), Positives = 87/257 (33%), Gaps = 41/257 (15%)
Query: 35 IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ 94
I QP A G +RC ++ + W DG + R G L +
Sbjct: 44 ISQPEVYVAAPGESLEVRCLLKDAAVIS--WTKDGVHLGPNNRTVLIGEYLQIKGATP-R 100
Query: 95 DSGTFQCVA------------------------RDDVTGEEARSANASFNIK---WIEAG 127
DSG + C A DD G E + S N + W
Sbjct: 101 DSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE 160
Query: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNL 185
+ + A A V RC G+P PT +W ++G + V ++ +L
Sbjct: 161 KMEKRLHAVPAA----NTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
Query: 186 TLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEA 242
+ P G Y+C + +G + + L + + S R +L P + +
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 274
Query: 243 MFHCQFSAQPPPSLQWL 259
F C+ + P +QW+
Sbjct: 275 EFVCKVYSDAQPHIQWI 291
Score = 37.0 bits (84), Expect = 0.086
Identities = 55/232 (23%), Positives = 87/232 (37%), Gaps = 56/232 (24%)
Query: 132 KHPASEAEIQ---PQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLR 188
K+ S+ E+ P + +RC + W +DG L G +N TV E L ++
Sbjct: 41 KYQISQPEVYVAAPGESLEVRCLLKD--AAVISWTKDGVHL--GPNNRTVLIGEY-LQIK 95
Query: 189 PAGPEHSGLYSCCAHSAFGQACSSQNFTLSIAD--------------ESF----ARVVLA 230
A P SGLY+C A + F +++ D E F + A
Sbjct: 96 GATPRDSGLYACTASRTVDS--ETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153
Query: 231 PQDVVVARYEEAM----------FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPH 274
P + E+ + F C P P+++WL F+ E I + R H
Sbjct: 154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 213
Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP 326
SL++ V P + G Y C+ + + G + T HL +E P
Sbjct: 214 ---------WSLIMESVVPSDKGNYTCVVENEYGS---INHTYHLDVVERSP 253
>gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isoform
a precursor [Homo sapiens]
Length = 839
Score = 221 bits (562), Expect = 3e-57
Identities = 181/625 (28%), Positives = 283/625 (45%), Gaps = 84/625 (13%)
Query: 381 IAESDAGVYTCHAANLAGQRRQDVNITVANGSSLP------EWVTDNAGTLHFARVTRDD 434
+ E D V TC N +G DV+ V S+ W +A L VT +D
Sbjct: 221 VREGDNAVITC---NGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSED 277
Query: 435 AG-NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQC---EAQGDPK 490
G TCIA N G A V LTV P ++ + L C +G+P
Sbjct: 278 NGFTLTCIAEN-VVGMSNASVALTVYY------PPRVVSLEEPELRLEHCIEFVVRGNPP 330
Query: 491 PLIQWKGKDRILDPTKLGPRMHI-------FQNGSLVIHDVAPEDSGRYTCIAGNSCNIK 543
P + W + L +K+ +H+ G L+ + ++G YT IA N
Sbjct: 331 PTLHWLHNGQPLRESKI---IHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTA 387
Query: 544 HTEAPLYVVDKPVPEESEG-----PGSPPPYKMI------QTIGLSVG---AAVAYIIAV 589
+ + + +P PE ++ SP P + T G+S+ AA A ++ V
Sbjct: 388 NQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLV 447
Query: 590 LGLMFYCKKRCKAKRLQKQP----EGEEPEMECLNGGPLQNGQPSA-EIQEEVALTSLGS 644
+ + K ++K K P GEE L+ PS+ + + + +
Sbjct: 448 VLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTR 507
Query: 645 GPAATNKRH-STSDKMHFPRSSLQPITT--------LGKSEFGEVFLAKAQGLEEGVAET 695
P N ++ H P + +Q I LG+ FG+VFLA+ L +
Sbjct: 508 IPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKM 567
Query: 696 LVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQ 755
LV VK+L+ + DF+RE E+ L H ++V+ G+C + +P MV EY+ GDL +
Sbjct: 568 LVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNK 627
Query: 756 FLR-------ISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLV 808
FLR I + L Q + + +Q+A GM +L++ FVH+DLA RNCLV
Sbjct: 628 FLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLV 687
Query: 809 SAQRQVKVSALGLSKDVYNSEYYHF---------------RQAWVPLRWMSPEAILEGDF 853
A VK+ G+S+DVY+++YY +P+RWM PE+I+ F
Sbjct: 688 GANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKF 747
Query: 854 STKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRC 913
+T+SDVW+FGV++WE+FT+G+ P ++ EV+ + G+ L +P CP ++Y +M C
Sbjct: 748 TTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRV-LERPRVCPKEVYDVMLGC 806
Query: 914 WALSPKDRPSFSE---IASALGDST 935
W P+ R + E I ALG +T
Sbjct: 807 WQREPQQRLNIKEIYKILHALGKAT 831
Score = 34.3 bits (77), Expect = 0.56
Identities = 39/150 (26%), Positives = 57/150 (38%), Gaps = 22/150 (14%)
Query: 437 NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW- 495
N CI ++G Q + + ++ V TV +G A++ C G P P + W
Sbjct: 186 NLYCINADGSQLPL-FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWI 244
Query: 496 -KGKDRI-LDPTKLG-PRMHIFQNGSLVIHDVAPEDSG-RYTCIAGNSCNIKHTEAPLYV 551
G I T L +H +L + +V ED+G TCIA N + + L V
Sbjct: 245 VTGLQSINTHQTNLNWTNVHAI---NLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTV 301
Query: 552 VDKPVPEESEGP-------------GSPPP 568
P E P G+PPP
Sbjct: 302 YYPPRVVSLEEPELRLEHCIEFVVRGNPPP 331
Score = 33.9 bits (76), Expect = 0.73
Identities = 44/203 (21%), Positives = 72/203 (35%), Gaps = 22/203 (10%)
Query: 215 FTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPH 274
F ++I+ + ++ ++ V + A+ C S P P + W+ I + +
Sbjct: 200 FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSI--NTHQTN 257
Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFT 334
L V A L+ N CI + G + A + + PRV +
Sbjct: 258 LNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVG--------MSNASVALTVYYPPRVVS 309
Query: 335 AGSEE--RVTCLP--PKGLPEPSVWWEHAGVRLP----THGRVYQKGHE----LVLANIA 382
E C+ +G P P++ W H G L H YQ+G L+
Sbjct: 310 LEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPT 369
Query: 383 ESDAGVYTCHAANLAGQRRQDVN 405
+ G YT A N G Q +N
Sbjct: 370 HYNNGNYTLIAKNPLGTANQTIN 392
Score = 31.6 bits (70), Expect = 3.6
Identities = 41/180 (22%), Positives = 75/180 (41%), Gaps = 20/180 (11%)
Query: 45 QGRRALLRCEVEAPGPVHVYWLLDGAP---VQDTERRFAQGSSLSFAAVD-RLQDSG-TF 99
+G A++ C V W++ G T + +++ V+ +D+G T
Sbjct: 223 EGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282
Query: 100 QCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPT 159
C+A ++V G +NAS + + P V+ E ++ + +R G+P PT
Sbjct: 283 TCIA-ENVVG----MSNASVALT-VYYPPRVVSLEEPELRLEHCIEFVVR----GNPPPT 332
Query: 160 YQWFRDGTPLSDGQSNHTVSSKERNLT---LRPAGPEH--SGLYSCCAHSAFGQACSSQN 214
W +G PL + + H +E ++ L P H +G Y+ A + G A + N
Sbjct: 333 LHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTIN 392
>gi|222144241 fibroblast growth factor receptor 2 isoform 8
precursor [Homo sapiens]
Length = 704
Score = 220 bits (561), Expect = 4e-57
Identities = 162/549 (29%), Positives = 260/549 (47%), Gaps = 61/549 (11%)
Query: 430 VTRDDAGNYTCIASNGPQGQIRAHVQLTVAV------FITFKVEPERTTVYQGHTALLQC 483
V D GNYTC+ N G I L V + + +TV G + C
Sbjct: 106 VVPSDKGNYTCVVEN-EYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV-C 163
Query: 484 EAQGDPKPLIQWKGKDRILDPTKLGPR----MHIFQNGS----------LVIHDVAPEDS 529
+ D +P IQW K + +K GP + + + L I +V ED+
Sbjct: 164 KVYSDAQPHIQWI-KHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDA 222
Query: 530 GRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAV 589
G YTC+AGNS I A L V+ P P + + P Y I + V ++ V
Sbjct: 223 GEYTCLAGNSIGISFHSAWLTVL--PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTV 280
Query: 590 LGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNGQPSAEIQEE-------VALTS 641
+ C+ K K+P+ +P + L Q SAE V +T+
Sbjct: 281 I--------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITT 332
Query: 642 LGSGPAATNKRHSTSD-------KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAE 694
S A T S+ K FPR L LG+ FG+V +A+A G+++ +
Sbjct: 333 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 392
Query: 695 TLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDL 750
V V KD+ + D E+EM + H N++ LLG C + P Y+++EY
Sbjct: 393 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 452
Query: 751 GDLKQFLRISKSKD-------EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAA 803
G+L+++LR + ++ + ++ K V+ Q+A GME+L++ + +H+DLAA
Sbjct: 453 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 512
Query: 804 RNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVWAF 862
RN LV+ +K++ GL++D+ N +YY +P++WM+PEA+ + ++ +SDVW+F
Sbjct: 513 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 572
Query: 863 GVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRP 922
GVLMWE+FT G P+ G +E+ L+ G R+ +P C ++LY +M+ CW P RP
Sbjct: 573 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPANCTNELYMMMRDCWHAVPSQRP 631
Query: 923 SFSEIASAL 931
+F ++ L
Sbjct: 632 TFKQLVEDL 640
Score = 45.8 bits (107), Expect = 2e-04
Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 2/85 (2%)
Query: 463 TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVI 521
T K+E V +T +C A G+P P ++W K ++G Q+ SL++
Sbjct: 44 TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIM 103
Query: 522 HDVAPEDSGRYTCIAGNSC-NIKHT 545
V P D G YTC+ N +I HT
Sbjct: 104 ESVVPSDKGNYTCVVENEYGSINHT 128
Score = 43.9 bits (102), Expect = 7e-04
Identities = 26/119 (21%), Positives = 49/119 (41%), Gaps = 7/119 (5%)
Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
V RC G+P PT +W ++G + V ++ +L + P G Y+C
Sbjct: 60 VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 119
Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
+ +G + + L + + S R +L P + + F C+ + P +QW+
Sbjct: 120 NEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI 176
>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform
c precursor [Homo sapiens]
Length = 822
Score = 220 bits (560), Expect = 6e-57
Identities = 167/571 (29%), Positives = 266/571 (46%), Gaps = 73/571 (12%)
Query: 423 GTLHFARVTRDDAGNY-TCIASNGPQGQIRAHVQLTV--AVFITFKVEPERTTVYQGHTA 479
G+L ++ DD+G +C+A N G+ + V LTV A ITF P H
Sbjct: 248 GSLRITNISSDDSGKQISCVAEN-LVGEDQDSVNLTVHFAPTITFLESPT-----SDHHW 301
Query: 480 LLQCEAQGDPKPLIQWKGKDRILDP-----TKLGPRMHIFQNGSLVIHDVAPEDSGRYTC 534
+ +G+PKP +QW IL+ TK+ H +G L + + ++G YT
Sbjct: 302 CIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTL 361
Query: 535 IAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPP-YKMIQTIGLSVGA------------ 581
IA N + + + P ++ P P Y+ T +G
Sbjct: 362 IAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTD 421
Query: 582 -------------AVAYIIAVLG-----LMFYCKKRCKAKRLQKQP--------EGEEPE 615
AV I +V+G ++F K +K K P + P
Sbjct: 422 VTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPL 481
Query: 616 MECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHS--TSDKM-------HFPRSSL 666
NG N S+E + + + P N ++ T+ ++ H R ++
Sbjct: 482 HHISNGS---NTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNI 538
Query: 667 QPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHA 726
LG+ FG+VFLA+ L + LV VK+L+ + + DF RE E+ L H
Sbjct: 539 VLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHE 598
Query: 727 NVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ-----PLSTKQKVALC 781
++V+ G+C E +P MV EY+ GDL +FLR + D L ++ L+ Q + +
Sbjct: 599 HIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLR-AHGPDAVLMAEGNPPTELTQSQMLHIA 657
Query: 782 TQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHF-RQAWVPL 840
Q+A GM +L++ FVH+DLA RNCLV VK+ G+S+DVY+++YY +P+
Sbjct: 658 QQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPI 717
Query: 841 RWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPE 900
RWM PE+I+ F+T+SDVW+ GV++WE+FT+G+ P +++EV+ + G+ L +P
Sbjct: 718 RWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRV-LQRPR 776
Query: 901 GCPSKLYRLMQRCWALSPKDRPSFSEIASAL 931
CP ++Y LM CW P R + I + L
Sbjct: 777 TCPQEVYELMLGCWQREPHMRKNIKGIHTLL 807
Score = 37.4 bits (85), Expect = 0.066
Identities = 36/172 (20%), Positives = 68/172 (39%), Gaps = 20/172 (11%)
Query: 45 QGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVAR 104
+G+ L C V ++YW + + SL + CVA
Sbjct: 210 EGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVA- 268
Query: 105 DDVTGEEARSANASFNIKWIEAGPVV--LKHPASEAEIQPQTQVTLRCHIDGHPRPTYQW 162
+++ GE+ S N + + P + L+ P S+ + + G+P+P QW
Sbjct: 269 ENLVGEDQDSVNLT-----VHFAPTITFLESPTSDHHW------CIPFTVKGNPKPALQW 317
Query: 163 FRDGTPLSDGQ----SNHTVSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQ 208
F +G L++ + H + E + L+ P H +G Y+ A + +G+
Sbjct: 318 FYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGK 369
Score = 33.9 bits (76), Expect = 0.73
Identities = 28/95 (29%), Positives = 40/95 (42%), Gaps = 5/95 (5%)
Query: 472 TVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGR 531
TV +G + L C GDP P + W + L + H GSL I +++ +DSG+
Sbjct: 207 TVEEGKSITLSCSVAGDPVPNMYWDVGN--LVSKHMNETSH--TQGSLRITNISSDDSGK 262
Query: 532 -YTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGS 565
+C+A N L V P E P S
Sbjct: 263 QISCVAENLVGEDQDSVNLTVHFAPTITFLESPTS 297
Score = 33.5 bits (75), Expect = 0.96
Identities = 44/179 (24%), Positives = 66/179 (36%), Gaps = 18/179 (10%)
Query: 135 ASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEH 194
A ++ +TL C + G P P W D L N T S + +L + +
Sbjct: 203 APNLTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNET-SHTQGSLRITNISSDD 259
Query: 195 SG-LYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPP 253
SG SC A + G+ S N T+ FA + + + F P
Sbjct: 260 SGKQISCVAENLVGEDQDSVNLTV-----HFAPTITFLESPTSDHHWCIPF--TVKGNPK 312
Query: 254 PSLQWLFEDETPITNRSR----PPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRG 308
P+LQW + I N S+ H+ T + +G L L N G Y I + + G
Sbjct: 313 PALQWFYNG--AILNESKYICTKIHVTNHTEY-HGCLQLDNPTHMNNGDYTLIAKNEYG 368
>gi|222144237 fibroblast growth factor receptor 2 isoform 6
precursor [Homo sapiens]
Length = 706
Score = 219 bits (558), Expect = 9e-57
Identities = 158/551 (28%), Positives = 259/551 (47%), Gaps = 63/551 (11%)
Query: 430 VTRDDAGNYTCIASNGPQGQIRAHVQLTVAV------FITFKVEPERTTVYQGHTALLQC 483
V D GNYTC+ N G I L V + + +TV G + C
Sbjct: 106 VVPSDKGNYTCVVEN-EYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV-C 163
Query: 484 EAQGDPKPLIQWKGKDRILDPTKLGPR----MHIFQNGS----------LVIHDVAPEDS 529
+ D +P IQW K + +K GP + + + L I +V ED+
Sbjct: 164 KVYSDAQPHIQWI-KHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDA 222
Query: 530 GRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAV 589
G YTC+AGNS I A L V+ P P + + P Y I + V ++ V
Sbjct: 223 GEYTCLAGNSIGISFHSAWLTVL--PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTV 280
Query: 590 LGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAA 648
+ C+ K K+P+ +P + L Q + + ++ S
Sbjct: 281 I--------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRI 332
Query: 649 TNKRHSTSD----------------KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGV 692
T + ST+D K FPR L LG+ FG+V +A+A G+++
Sbjct: 333 TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 392
Query: 693 AETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYV 748
+ V V KD+ + D E+EM + H N++ LLG C + P Y+++EY
Sbjct: 393 PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA 452
Query: 749 DLGDLKQFLRISKSKD-------EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDL 801
G+L+++LR + ++ + ++ K V+ Q+A GME+L++ + +H+DL
Sbjct: 453 SKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDL 512
Query: 802 AARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVW 860
AARN LV+ +K++ GL++D+ N +YY +P++WM+PEA+ + ++ +SDVW
Sbjct: 513 AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 572
Query: 861 AFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKD 920
+FGVLMWE+FT G P+ G +E+ L+ G R+ +P C ++LY +M+ CW P
Sbjct: 573 SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPANCTNELYMMMRDCWHAVPSQ 631
Query: 921 RPSFSEIASAL 931
RP+F ++ L
Sbjct: 632 RPTFKQLVEDL 642
Score = 45.8 bits (107), Expect = 2e-04
Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 2/85 (2%)
Query: 463 TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVI 521
T K+E V +T +C A G+P P ++W K ++G Q+ SL++
Sbjct: 44 TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIM 103
Query: 522 HDVAPEDSGRYTCIAGNSC-NIKHT 545
V P D G YTC+ N +I HT
Sbjct: 104 ESVVPSDKGNYTCVVENEYGSINHT 128
Score = 43.9 bits (102), Expect = 7e-04
Identities = 26/119 (21%), Positives = 49/119 (41%), Gaps = 7/119 (5%)
Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
V RC G+P PT +W ++G + V ++ +L + P G Y+C
Sbjct: 60 VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 119
Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
+ +G + + L + + S R +L P + + F C+ + P +QW+
Sbjct: 120 NEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI 176
>gi|222144235 fibroblast growth factor receptor 2 isoform 5
precursor [Homo sapiens]
Length = 707
Score = 219 bits (558), Expect = 9e-57
Identities = 158/551 (28%), Positives = 259/551 (47%), Gaps = 63/551 (11%)
Query: 430 VTRDDAGNYTCIASNGPQGQIRAHVQLTVAV------FITFKVEPERTTVYQGHTALLQC 483
V D GNYTC+ N G I L V + + +TV G + C
Sbjct: 132 VVPSDKGNYTCVVEN-EYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV-C 189
Query: 484 EAQGDPKPLIQWKGKDRILDPTKLGPR----MHIFQNGS----------LVIHDVAPEDS 529
+ D +P IQW K + +K GP + + + L I +V ED+
Sbjct: 190 KVYSDAQPHIQWI-KHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDA 248
Query: 530 GRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAV 589
G YTC+AGNS I A L V+ P P + + P Y I + V ++ V
Sbjct: 249 GEYTCLAGNSIGISFHSAWLTVL--PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTV 306
Query: 590 LGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAA 648
+ C+ K K+P+ +P + L Q + + ++ S
Sbjct: 307 I--------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRI 358
Query: 649 TNKRHSTSD----------------KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGV 692
T + ST+D K FPR L LG+ FG+V +A+A G+++
Sbjct: 359 TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 418
Query: 693 AETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYV 748
+ V V KD+ + D E+EM + H N++ LLG C + P Y+++EY
Sbjct: 419 PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA 478
Query: 749 DLGDLKQFLRISKSKD-------EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDL 801
G+L+++LR + ++ + ++ K V+ Q+A GME+L++ + +H+DL
Sbjct: 479 SKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDL 538
Query: 802 AARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVW 860
AARN LV+ +K++ GL++D+ N +YY +P++WM+PEA+ + ++ +SDVW
Sbjct: 539 AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 598
Query: 861 AFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKD 920
+FGVLMWE+FT G P+ G +E+ L+ G R+ +P C ++LY +M+ CW P
Sbjct: 599 SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPANCTNELYMMMRDCWHAVPSQ 657
Query: 921 RPSFSEIASAL 931
RP+F ++ L
Sbjct: 658 RPTFKQLVEDL 668
Score = 45.8 bits (107), Expect = 2e-04
Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 2/85 (2%)
Query: 463 TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVI 521
T K+E V +T +C A G+P P ++W K ++G Q+ SL++
Sbjct: 70 TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIM 129
Query: 522 HDVAPEDSGRYTCIAGNSC-NIKHT 545
V P D G YTC+ N +I HT
Sbjct: 130 ESVVPSDKGNYTCVVENEYGSINHT 154
Score = 43.9 bits (102), Expect = 7e-04
Identities = 26/119 (21%), Positives = 49/119 (41%), Gaps = 7/119 (5%)
Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
V RC G+P PT +W ++G + V ++ +L + P G Y+C
Sbjct: 86 VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 145
Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
+ +G + + L + + S R +L P + + F C+ + P +QW+
Sbjct: 146 NEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI 202
>gi|221316639 fibroblast growth factor receptor 2 isoform 1
precursor [Homo sapiens]
Length = 821
Score = 219 bits (558), Expect = 9e-57
Identities = 158/551 (28%), Positives = 259/551 (47%), Gaps = 63/551 (11%)
Query: 430 VTRDDAGNYTCIASNGPQGQIRAHVQLTVAV------FITFKVEPERTTVYQGHTALLQC 483
V D GNYTC+ N G I L V + + +TV G + C
Sbjct: 221 VVPSDKGNYTCVVEN-EYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV-C 278
Query: 484 EAQGDPKPLIQWKGKDRILDPTKLGPR----MHIFQNGS----------LVIHDVAPEDS 529
+ D +P IQW K + +K GP + + + L I +V ED+
Sbjct: 279 KVYSDAQPHIQWI-KHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDA 337
Query: 530 GRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAV 589
G YTC+AGNS I A L V+ P P + + P Y I + V ++ V
Sbjct: 338 GEYTCLAGNSIGISFHSAWLTVL--PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTV 395
Query: 590 LGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAA 648
+ C+ K K+P+ +P + L Q + + ++ S
Sbjct: 396 I--------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRI 447
Query: 649 TNKRHSTSD----------------KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGV 692
T + ST+D K FPR L LG+ FG+V +A+A G+++
Sbjct: 448 TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 507
Query: 693 AETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYV 748
+ V V KD+ + D E+EM + H N++ LLG C + P Y+++EY
Sbjct: 508 PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA 567
Query: 749 DLGDLKQFLRISKSKD-------EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDL 801
G+L+++LR + ++ + ++ K V+ Q+A GME+L++ + +H+DL
Sbjct: 568 SKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDL 627
Query: 802 AARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVW 860
AARN LV+ +K++ GL++D+ N +YY +P++WM+PEA+ + ++ +SDVW
Sbjct: 628 AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 687
Query: 861 AFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKD 920
+FGVLMWE+FT G P+ G +E+ L+ G R+ +P C ++LY +M+ CW P
Sbjct: 688 SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPANCTNELYMMMRDCWHAVPSQ 746
Query: 921 RPSFSEIASAL 931
RP+F ++ L
Sbjct: 747 RPTFKQLVEDL 757
Score = 55.5 bits (132), Expect = 2e-07
Identities = 54/222 (24%), Positives = 84/222 (37%), Gaps = 29/222 (13%)
Query: 329 EPRVFTA--GSEERVTCLPPKGLPEPSVW-WEHAGVRLPTHGRVYQKGHELVLANIAESD 385
+P V+ A G V CL L + +V W GV L + R G L + D
Sbjct: 46 QPEVYVAAPGESLEVRCL----LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRD 101
Query: 386 AGVYTCHAANLAGQRRQDVNITVANGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNG 445
+G+Y C A+ + V + S + D D A ++ SN
Sbjct: 102 SGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDT-----------DGAEDFVSENSNN 150
Query: 446 PQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDP 504
+ + + K+E V +T +C A G+P P ++W K
Sbjct: 151 KRAPYWTNTE---------KMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQE 201
Query: 505 TKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSC-NIKHT 545
++G Q+ SL++ V P D G YTC+ N +I HT
Sbjct: 202 HRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT 243
Score = 47.0 bits (110), Expect = 8e-05
Identities = 53/257 (20%), Positives = 87/257 (33%), Gaps = 41/257 (15%)
Query: 35 IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ 94
I QP A G +RC ++ + W DG + R G L +
Sbjct: 44 ISQPEVYVAAPGESLEVRCLLKDAAVIS--WTKDGVHLGPNNRTVLIGEYLQIKGATP-R 100
Query: 95 DSGTFQCVA------------------------RDDVTGEEARSANASFNIK---WIEAG 127
DSG + C A DD G E + S N + W
Sbjct: 101 DSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE 160
Query: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNL 185
+ + A A V RC G+P PT +W ++G + V ++ +L
Sbjct: 161 KMEKRLHAVPAA----NTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
Query: 186 TLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEA 242
+ P G Y+C + +G + + L + + S R +L P + +
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 274
Query: 243 MFHCQFSAQPPPSLQWL 259
F C+ + P +QW+
Sbjct: 275 EFVCKVYSDAQPHIQWI 291
Score = 42.4 bits (98), Expect = 0.002
Identities = 81/359 (22%), Positives = 123/359 (34%), Gaps = 82/359 (22%)
Query: 132 KHPASEAEIQ---PQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLR 188
K+ S+ E+ P + +RC + W +DG L G +N TV E L ++
Sbjct: 41 KYQISQPEVYVAAPGESLEVRCLLKD--AAVISWTKDGVHL--GPNNRTVLIGEY-LQIK 95
Query: 189 PAGPEHSGLYSCCAHSAFGQACSSQNFTLSIAD--------------ESF----ARVVLA 230
A P SGLY+C A + F +++ D E F + A
Sbjct: 96 GATPRDSGLYACTASRTVDS--ETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153
Query: 231 PQDVVVARYEEAM----------FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPH 274
P + E+ + F C P P+++WL F+ E I + R H
Sbjct: 154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 213
Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP-------- 326
SL++ V P + G Y C+ + + G + T HL +E P
Sbjct: 214 ---------WSLIMESVVPSDKGNYTCVVENEYGS---INHTYHLDVVERSPHRPILQAG 261
Query: 327 LFEPRVFTAGSEERVTCLPPKGLPEPSVWW----EHAGVRLPTHGRVYQKG--------- 373
L G + C +P + W E G + G Y K
Sbjct: 262 LPANASTVVGGDVEFVCKVYSD-AQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTT 320
Query: 374 ----HELVLANIAESDAGVYTCHAANLAGQRRQDVNITVANGSSLPEWVTDNAGTLHFA 428
L + N+ DAG YTC A N G +TV + +T + L A
Sbjct: 321 DKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIA 379
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 218 bits (556), Expect = 2e-56
Identities = 180/634 (28%), Positives = 289/634 (45%), Gaps = 91/634 (14%)
Query: 335 AGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHG-------RVYQKGHELVLANIAESDAG 387
AG+ + C P G P P++ W G HG R+ + LV+ ++ SD G
Sbjct: 164 AGNTVKFRC-PAAGNPTPTIRWLKDGQAF--HGENRIGGIRLRHQHWSLVMESVVPSDRG 220
Query: 388 VYTCHAANLAGQRRQDVNITVANGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQ 447
YTC N G R + + V S P AG
Sbjct: 221 TYTCLVENAVGSIRYNYLLDVLERS--PHRPILQAGL----------------------- 255
Query: 448 GQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKL 507
P TT G L C+ D +P IQW K +++ +
Sbjct: 256 --------------------PANTTAVVGSDVELLCKVYSDAQPHIQWL-KHIVINGSSF 294
Query: 508 G----PRMHIFQNGS--------LVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKP 555
G P + + + L + +V+ ED+G YTC+AGNS + + A L V+ +
Sbjct: 295 GADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEE 354
Query: 556 VPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL--GLMFYCKKRCKAKRLQKQPEGEE 613
P + +I S+ AV ++A L G + + +QK
Sbjct: 355 DPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPL 414
Query: 614 PEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKM----HFPRSSLQPI 669
L G +G+ S+ + V L+S SGPA S + FPR L
Sbjct: 415 ARQFSLESG--SSGKSSSSLVRGVRLSS--SGPALLAGLVSLDLPLDPLWEFPRDRLVLG 470
Query: 670 TTLGKSEFGEVFLAKAQGLEEGVAE--TLVLVKSLQSKDEQQQL-DFRRELEMFGKL-NH 725
LG+ FG+V A+A G++ + + V VK L+ + L D E+E+ + H
Sbjct: 471 KPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRH 530
Query: 726 ANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISK------SKDEKLKSQ-PLSTKQKV 778
N++ LLG+C + P Y+++E G+L++FLR + S D S+ PLS V
Sbjct: 531 KNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLV 590
Query: 779 ALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYY-HFRQAW 837
+ QVA GM++L + + +H+DLAARN LV+ +K++ GL++ V++ +YY
Sbjct: 591 SCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGR 650
Query: 838 VPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLP 897
+P++WM+PEA+ + ++ +SDVW+FG+L+WE+FT G P+ G +E+ + L+ G R+
Sbjct: 651 LPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH-RMD 709
Query: 898 QPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 931
+P CP +LY LM+ CW +P RP+F ++ AL
Sbjct: 710 RPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL 743
Score = 64.3 bits (155), Expect = 5e-10
Identities = 69/238 (28%), Positives = 93/238 (39%), Gaps = 30/238 (12%)
Query: 308 GPPII-LEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPK----GLPEPSVWWEHAGVR 362
GPP++ LEA+ E+E P P + E V P G E W G R
Sbjct: 16 GPPVLSLEAS---EEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSR 72
Query: 363 LPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVANGSSLPEWVTDNA 422
L GRV L +A+ DAG Y C A G N+T+ G SL D
Sbjct: 73 LAPAGRVRGWRGRLEIASFLPEDAGRYLCLAR---GSMIVLQNLTLITGDSLTSSNDDED 129
Query: 423 GTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQ 482
H RD + + S Q H Q ++E + V G+T +
Sbjct: 130 PKSH-----RDPSNRH----SYPQQAPYWTHPQ---------RMEKKLHAVPAGNTVKFR 171
Query: 483 CEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNS 539
C A G+P P I+W K ++G Q+ SLV+ V P D G YTC+ N+
Sbjct: 172 CPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENA 229
Score = 44.3 bits (103), Expect = 5e-04
Identities = 46/212 (21%), Positives = 74/212 (34%), Gaps = 26/212 (12%)
Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKER--NLTLRPAGPEHSGLYSCCAH 203
V RC G+P PT +W +DG + + + +L + P G Y+C
Sbjct: 168 VKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVE 227
Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWLF 260
+A G N+ L + + S R +L P + + C+ + P +QWL
Sbjct: 228 NAVGSI--RYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLK 285
Query: 261 E----------DETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPP 310
D P + + + V L L V +AG Y C+ G
Sbjct: 286 HIVINGSSFGADGFPYVQVLKTADINSSEVEV---LYLRNVSAEDAGEYTCLAGNSIG-- 340
Query: 311 IILEATLHLAEIEDMPLFEPRVFTAGSEERVT 342
+ A + +P +P A E R T
Sbjct: 341 ----LSYQSAWLTVLPEEDPTWTAAAPEARYT 368
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 218 bits (556), Expect = 2e-56
Identities = 180/634 (28%), Positives = 289/634 (45%), Gaps = 91/634 (14%)
Query: 335 AGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHG-------RVYQKGHELVLANIAESDAG 387
AG+ + C P G P P++ W G HG R+ + LV+ ++ SD G
Sbjct: 164 AGNTVKFRC-PAAGNPTPTIRWLKDGQAF--HGENRIGGIRLRHQHWSLVMESVVPSDRG 220
Query: 388 VYTCHAANLAGQRRQDVNITVANGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQ 447
YTC N G R + + V S P AG
Sbjct: 221 TYTCLVENAVGSIRYNYLLDVLERS--PHRPILQAGL----------------------- 255
Query: 448 GQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKL 507
P TT G L C+ D +P IQW K +++ +
Sbjct: 256 --------------------PANTTAVVGSDVELLCKVYSDAQPHIQWL-KHIVINGSSF 294
Query: 508 G----PRMHIFQNGS--------LVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKP 555
G P + + + L + +V+ ED+G YTC+AGNS + + A L V+ +
Sbjct: 295 GADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEE 354
Query: 556 VPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL--GLMFYCKKRCKAKRLQKQPEGEE 613
P + +I S+ AV ++A L G + + +QK
Sbjct: 355 DPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPL 414
Query: 614 PEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKM----HFPRSSLQPI 669
L G +G+ S+ + V L+S SGPA S + FPR L
Sbjct: 415 ARQFSLESG--SSGKSSSSLVRGVRLSS--SGPALLAGLVSLDLPLDPLWEFPRDRLVLG 470
Query: 670 TTLGKSEFGEVFLAKAQGLEEGVAE--TLVLVKSLQSKDEQQQL-DFRRELEMFGKL-NH 725
LG+ FG+V A+A G++ + + V VK L+ + L D E+E+ + H
Sbjct: 471 KPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRH 530
Query: 726 ANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISK------SKDEKLKSQ-PLSTKQKV 778
N++ LLG+C + P Y+++E G+L++FLR + S D S+ PLS V
Sbjct: 531 KNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLV 590
Query: 779 ALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYY-HFRQAW 837
+ QVA GM++L + + +H+DLAARN LV+ +K++ GL++ V++ +YY
Sbjct: 591 SCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGR 650
Query: 838 VPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLP 897
+P++WM+PEA+ + ++ +SDVW+FG+L+WE+FT G P+ G +E+ + L+ G R+
Sbjct: 651 LPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH-RMD 709
Query: 898 QPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 931
+P CP +LY LM+ CW +P RP+F ++ AL
Sbjct: 710 RPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL 743
Score = 64.3 bits (155), Expect = 5e-10
Identities = 69/238 (28%), Positives = 93/238 (39%), Gaps = 30/238 (12%)
Query: 308 GPPII-LEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPK----GLPEPSVWWEHAGVR 362
GPP++ LEA+ E+E P P + E V P G E W G R
Sbjct: 16 GPPVLSLEAS---EEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSR 72
Query: 363 LPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVANGSSLPEWVTDNA 422
L GRV L +A+ DAG Y C A G N+T+ G SL D
Sbjct: 73 LAPAGRVRGWRGRLEIASFLPEDAGRYLCLAR---GSMIVLQNLTLITGDSLTSSNDDED 129
Query: 423 GTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQ 482
H RD + + S Q H Q ++E + V G+T +
Sbjct: 130 PKSH-----RDPSNRH----SYPQQAPYWTHPQ---------RMEKKLHAVPAGNTVKFR 171
Query: 483 CEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNS 539
C A G+P P I+W K ++G Q+ SLV+ V P D G YTC+ N+
Sbjct: 172 CPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENA 229
Score = 44.3 bits (103), Expect = 5e-04
Identities = 46/212 (21%), Positives = 74/212 (34%), Gaps = 26/212 (12%)
Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKER--NLTLRPAGPEHSGLYSCCAH 203
V RC G+P PT +W +DG + + + +L + P G Y+C
Sbjct: 168 VKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVE 227
Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWLF 260
+A G N+ L + + S R +L P + + C+ + P +QWL
Sbjct: 228 NAVGSI--RYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLK 285
Query: 261 E----------DETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPP 310
D P + + + V L L V +AG Y C+ G
Sbjct: 286 HIVINGSSFGADGFPYVQVLKTADINSSEVEV---LYLRNVSAEDAGEYTCLAGNSIG-- 340
Query: 311 IILEATLHLAEIEDMPLFEPRVFTAGSEERVT 342
+ A + +P +P A E R T
Sbjct: 341 ----LSYQSAWLTVLPEEDPTWTAAAPEARYT 368
>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
Length = 869
Score = 217 bits (553), Expect = 4e-56
Identities = 132/398 (33%), Positives = 214/398 (53%), Gaps = 40/398 (10%)
Query: 552 VDKP-VPEESEGPGS-PPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQP 609
VD P +P S S P Y M T+ +S+ ++ A + + YC C+ ++ K
Sbjct: 473 VDIPNLPSSSSSSFSVSPTYSM--TVIISIMSSFAIFVLLTITTLYC---CRRRKQWKNK 527
Query: 610 EGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKM---HFPRSSL 666
+ E + + E+ L L P + K+ +PR+++
Sbjct: 528 KRESAAVTLTT------------LPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNI 575
Query: 667 QPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSK-DEQQQLDFRRELEMFGKLNH 725
+ + +G+ FG VF A+A GL T+V VK L+ + Q DF+RE + + ++
Sbjct: 576 EYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDN 635
Query: 726 ANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKS--------KDEKLKSQ------- 770
N+V+LLG+C +P ++ EY+ GDL +FLR D +++Q
Sbjct: 636 PNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPP 695
Query: 771 PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 830
PLS +++ + QVA GM +LS +FVH+DLA RNCLV VK++ GLS+++Y+++Y
Sbjct: 696 PLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADY 755
Query: 831 YHFRQ-AWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADL 889
Y + +P+RWM PE+I ++T+SDVWA+GV++WE+F++G P+ G A +EV+ +
Sbjct: 756 YKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYV 815
Query: 890 QAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEI 927
+ G L PE CP +LY LM+ CW+ P DRPSF+ I
Sbjct: 816 RDGNI-LSCPENCPVELYNLMRLCWSKLPADRPSFTSI 852
Score = 75.9 bits (185), Expect = 2e-13
Identities = 66/294 (22%), Positives = 122/294 (41%), Gaps = 22/294 (7%)
Query: 130 VLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRP 189
V+ P + + T C ++ +P+P W R+ + + +++ + LT+
Sbjct: 29 VITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILS 88
Query: 190 AGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFS 249
G+Y C A++ G A S ++ + ++ P +V + +A+ C
Sbjct: 89 VEDSDDGIYCCTANNGVGGAVESCG---ALQVKMKPKITRPPINVKIIEGLKAVLPCTTM 145
Query: 250 AQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGP 309
P PS+ W+ + ++P+ S R V +GSL + V+ +AG YRC+ + G
Sbjct: 146 GNPKPSVSWI-KGDSPLRENS------RIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGT 198
Query: 310 PIILEATLHL---AEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTH 366
L + A I P E T GS + C G+P P++ W G +
Sbjct: 199 AYSKVVKLEVEVFARILRAP--ESHNVTFGSFVTLHC-TATGIPVPTITWIENG-NAVSS 254
Query: 367 GRVYQKGHELVLANIAE---SDAGVYTCHAANLAGQRRQDVNITVANGSSLPEW 417
G + + + V+ + + + G+YTC A N G++ A S+ EW
Sbjct: 255 GSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAK--AAATISIAEW 306
Score = 72.8 bits (177), Expect = 1e-12
Identities = 40/129 (31%), Positives = 63/129 (48%), Gaps = 3/129 (2%)
Query: 418 VTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGH 477
+ +N L V D G Y C A+NG G + + L V + P + +G
Sbjct: 77 IRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGL 136
Query: 478 TALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAG 537
A+L C G+PKP + W D P + R+ + ++GSL IH+V ED+G+Y C+A
Sbjct: 137 KAVLPCTTMGNPKPSVSWIKGD---SPLRENSRIAVLESGSLRIHNVQKEDAGQYRCVAK 193
Query: 538 NSCNIKHTE 546
NS +++
Sbjct: 194 NSLGTAYSK 202
Score = 60.5 bits (145), Expect = 7e-09
Identities = 62/257 (24%), Positives = 90/257 (35%), Gaps = 75/257 (29%)
Query: 350 PEPSVWWEHAGVRLP---THGRVYQKGHELVLANIAESDAGVYTCHAANLAGQR------ 400
P+P + W + + T + + G L + ++ +SD G+Y C A N G
Sbjct: 55 PQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGA 114
Query: 401 ----------RQDVNITVANG--SSLP-----------EWVTDNA-------------GT 424
R +N+ + G + LP W+ ++ G+
Sbjct: 115 LQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGS 174
Query: 425 LHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCE 484
L V ++DAG Y C+A N V+L V VF PE V G L C
Sbjct: 175 LRIHNVQKEDAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCT 234
Query: 485 AQGDPKPLIQW--------------KGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG 530
A G P P I W KDR++D R+ +F G
Sbjct: 235 ATGIPVPTITWIENGNAVSSGSIQESVKDRVID-----SRLQLFIT-----------KPG 278
Query: 531 RYTCIAGNSCNIKHTEA 547
YTCIA N K + A
Sbjct: 279 LYTCIATNKHGEKFSTA 295
Score = 57.4 bits (137), Expect = 6e-08
Identities = 49/193 (25%), Positives = 87/193 (45%), Gaps = 15/193 (7%)
Query: 36 KQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTER-RFAQGSSLSFAAVDRLQ 94
+ P + ++G +A+L C V W+ +P+++ R + SL V + +
Sbjct: 125 RPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQK-E 183
Query: 95 DSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDG 154
D+G ++CVA++ + ++ +E +L+ P S + + VTL C G
Sbjct: 184 DAGQYRCVAKNSLGTAYSKVVKLE-----VEVFARILRAPESH-NVTFGSFVTLHCTATG 237
Query: 155 HPRPTYQWFRDGTPLSDGQSNHTVSSK--ERNLTLRPAGPEHSGLYSCCAHSAFGQACSS 212
P PT W +G +S G +V + + L L P GLY+C A + G+ S+
Sbjct: 238 IPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKP---GLYTCIATNKHGEKFST 294
Query: 213 QN--FTLSIADES 223
T+SIA+ S
Sbjct: 295 AKAAATISIAEWS 307
>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform
a precursor [Homo sapiens]
Length = 838
Score = 214 bits (545), Expect = 3e-55
Identities = 167/584 (28%), Positives = 267/584 (45%), Gaps = 83/584 (14%)
Query: 423 GTLHFARVTRDDAGNY-TCIASNGPQGQIRAHVQLTV--AVFITFKVEPERTTVYQGHTA 479
G+L ++ DD+G +C+A N G+ + V LTV A ITF P H
Sbjct: 248 GSLRITNISSDDSGKQISCVAEN-LVGEDQDSVNLTVHFAPTITFLESPT-----SDHHW 301
Query: 480 LLQCEAQGDPKPLIQWKGKDRILDP-----TKLGPRMHIFQNGSLVIHDVAPEDSGRYTC 534
+ +G+PKP +QW IL+ TK+ H +G L + + ++G YT
Sbjct: 302 CIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTL 361
Query: 535 IAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPP-YKMIQTIGLSVGA------------ 581
IA N + + + P ++ P P Y+ T +G
Sbjct: 362 IAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTD 421
Query: 582 -------------AVAYIIAVLG----LMFYCKKRCKAKRLQ------------KQPEGE 612
AV I +V+G +M + K + + K +G
Sbjct: 422 VTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGV 481
Query: 613 EPEMECLN----GGPLQ------NGQPSAEIQEEVALTSLGSGPAATNKRHS--TSDKM- 659
P N PL N S+E + + + P N ++ T+ ++
Sbjct: 482 GPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLK 541
Query: 660 ------HFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDF 713
H R ++ LG+ FG+VFLA+ L + LV VK+L+ + + DF
Sbjct: 542 PDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDF 601
Query: 714 RRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ--- 770
RE E+ L H ++V+ G+C E +P MV EY+ GDL +FLR + D L ++
Sbjct: 602 HREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLR-AHGPDAVLMAEGNP 660
Query: 771 --PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNS 828
L+ Q + + Q+A GM +L++ FVH+DLA RNCLV VK+ G+S+DVY++
Sbjct: 661 PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYST 720
Query: 829 EYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLA 887
+YY +P+RWM PE+I+ F+T+SDVW+ GV++WE+FT+G+ P +++EV+
Sbjct: 721 DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIE 780
Query: 888 DLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 931
+ G+ L +P CP ++Y LM CW P R + I + L
Sbjct: 781 CITQGRV-LQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLL 823
Score = 37.4 bits (85), Expect = 0.066
Identities = 36/172 (20%), Positives = 68/172 (39%), Gaps = 20/172 (11%)
Query: 45 QGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVAR 104
+G+ L C V ++YW + + SL + CVA
Sbjct: 210 EGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVA- 268
Query: 105 DDVTGEEARSANASFNIKWIEAGPVV--LKHPASEAEIQPQTQVTLRCHIDGHPRPTYQW 162
+++ GE+ S N + + P + L+ P S+ + + G+P+P QW
Sbjct: 269 ENLVGEDQDSVNLT-----VHFAPTITFLESPTSDHHW------CIPFTVKGNPKPALQW 317
Query: 163 FRDGTPLSDGQ----SNHTVSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQ 208
F +G L++ + H + E + L+ P H +G Y+ A + +G+
Sbjct: 318 FYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGK 369
Score = 33.9 bits (76), Expect = 0.73
Identities = 28/95 (29%), Positives = 40/95 (42%), Gaps = 5/95 (5%)
Query: 472 TVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGR 531
TV +G + L C GDP P + W + L + H GSL I +++ +DSG+
Sbjct: 207 TVEEGKSITLSCSVAGDPVPNMYWDVGN--LVSKHMNETSH--TQGSLRITNISSDDSGK 262
Query: 532 -YTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGS 565
+C+A N L V P E P S
Sbjct: 263 QISCVAENLVGEDQDSVNLTVHFAPTITFLESPTS 297
Score = 33.5 bits (75), Expect = 0.96
Identities = 44/179 (24%), Positives = 66/179 (36%), Gaps = 18/179 (10%)
Query: 135 ASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEH 194
A ++ +TL C + G P P W D L N T S + +L + +
Sbjct: 203 APNLTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNET-SHTQGSLRITNISSDD 259
Query: 195 SG-LYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPP 253
SG SC A + G+ S N T+ FA + + + F P
Sbjct: 260 SGKQISCVAENLVGEDQDSVNLTV-----HFAPTITFLESPTSDHHWCIPF--TVKGNPK 312
Query: 254 PSLQWLFEDETPITNRSR----PPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRG 308
P+LQW + I N S+ H+ T + +G L L N G Y I + + G
Sbjct: 313 PALQWFYNG--AILNESKYICTKIHVTNHTEY-HGCLQLDNPTHMNNGDYTLIAKNEYG 368
>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
Length = 1620
Score = 210 bits (535), Expect = 4e-54
Identities = 124/381 (32%), Positives = 207/381 (54%), Gaps = 25/381 (6%)
Query: 565 SPPPYKMIQTIGLSVGAAV--AYIIAVLGLMFYCKKRCKAKRLQK-QPEGEEPEMECLNG 621
+P P+ + I V +A+ A ++A G+M ++ K + LQ Q E + PE +
Sbjct: 1026 TPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRR--KHQELQAMQMELQSPEYKL--- 1080
Query: 622 GPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVF 681
++++ +T K S SD PR ++ I LG FGEV+
Sbjct: 1081 ---------SKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVY 1131
Query: 682 LAKAQGLEEGVAETLVLVKSLQSK-DEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEP 740
+ G+ + V VK+L EQ +LDF E + K NH N+VR +G+ ++ P
Sbjct: 1132 EGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLP 1191
Query: 741 HYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKD 800
+++LE + GDLK FLR ++ + + S L+ + + +A G ++L N F+H+D
Sbjct: 1192 RFILLELMAGGDLKSFLRETRPRPSQPSS--LAMLDLLHVARDIACGCQYLEENHFIHRD 1249
Query: 801 LAARNCLVSAQ---RQVKVSALGLSKDVYNSEYYHFRQ-AWVPLRWMSPEAILEGDFSTK 856
+AARNCL++ R K+ G+++D+Y + YY A +P++WM PEA +EG F++K
Sbjct: 1250 IAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSK 1309
Query: 857 SDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWAL 916
+D W+FGVL+WE+F+ G MP+ +++ EVL + +G R+ P+ CP +YR+M +CW
Sbjct: 1310 TDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSG-GRMDPPKNCPGPVYRIMTQCWQH 1368
Query: 917 SPKDRPSFSEIASALGDSTVD 937
P+DRP+F+ I + T D
Sbjct: 1369 QPEDRPNFAIILERIEYCTQD 1389
>gi|222144244 fibroblast growth factor receptor 2 isoform 9
precursor [Homo sapiens]
Length = 680
Score = 207 bits (526), Expect = 5e-53
Identities = 154/550 (28%), Positives = 253/550 (46%), Gaps = 60/550 (10%)
Query: 430 VTRDDAGNYTCIASNGPQGQIRAHVQLTVAV------FITFKVEPERTTVYQGHTALLQC 483
V D GNYTC+ N G I L V + + +TV G + C
Sbjct: 132 VVPSDKGNYTCVVEN-EYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV-C 189
Query: 484 EAQGDPKPLIQWKGKDRILDPTKLGPR--------MHIFQNGS----LVIHDVAPEDSGR 531
+ D +P IQW K + +K GP H N S L + +V D+G
Sbjct: 190 KVYSDAQPHIQWI-KHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGE 248
Query: 532 YTCIAGNSCNIKHTEAPLYVVDKP-VPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL 590
Y C N + A L V+ K P + + P Y I + V ++ V+
Sbjct: 249 YICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVI 308
Query: 591 GLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAAT 649
C+ K K+P+ +P + L Q + + ++ S T
Sbjct: 309 --------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRIT 360
Query: 650 NKRHSTSD----------------KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVA 693
+ ST+D K FPR L LG+ FG+V +A+A G+++
Sbjct: 361 TRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKP 420
Query: 694 ETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVD 749
+ V V KD+ + D E+EM + H N++ LLG C + P Y+++EY
Sbjct: 421 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 480
Query: 750 LGDLKQFLRISKSKD-------EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLA 802
G+L+++LR + ++ + ++ K V+ Q+A GME+L++ + +H+DLA
Sbjct: 481 KGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLA 540
Query: 803 ARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVWA 861
ARN LV+ +K++ GL++D+ N +YY +P++WM+PEA+ + ++ +SDVW+
Sbjct: 541 ARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 600
Query: 862 FGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDR 921
FGVLMWE+FT G P+ G +E+ L+ G R+ +P C ++LY +M+ CW P R
Sbjct: 601 FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPANCTNELYMMMRDCWHAVPSQR 659
Query: 922 PSFSEIASAL 931
P+F ++ L
Sbjct: 660 PTFKQLVEDL 669
Score = 45.8 bits (107), Expect = 2e-04
Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 2/85 (2%)
Query: 463 TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVI 521
T K+E V +T +C A G+P P ++W K ++G Q+ SL++
Sbjct: 70 TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIM 129
Query: 522 HDVAPEDSGRYTCIAGNSC-NIKHT 545
V P D G YTC+ N +I HT
Sbjct: 130 ESVVPSDKGNYTCVVENEYGSINHT 154
Score = 45.1 bits (105), Expect = 3e-04
Identities = 49/200 (24%), Positives = 69/200 (34%), Gaps = 40/200 (20%)
Query: 244 FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPHLRRATVFANGSLLLTQVRPRNAG 297
F C P P+++WL F+ E I + R H SL++ V P + G
Sbjct: 88 FRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHW---------SLIMESVVPSDKG 138
Query: 298 IYRCIGQGQRGPPIILEATLHLAEIEDMP--------LFEPRVFTAGSEERVTCLPPKGL 349
Y C+ + + G + T HL +E P L G + C
Sbjct: 139 NYTCVVENEYGS---INHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDA 195
Query: 350 PEPSVWWEHA---GVRLPTHGRVYQK-----------GHELVLANIAESDAGVYTCHAAN 395
W +H G + G Y K L L N+ E+DAG Y C +N
Sbjct: 196 QPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSN 255
Query: 396 LAGQRRQDVNITVANGSSLP 415
GQ Q +TV P
Sbjct: 256 YIGQANQSAWLTVLPKQQAP 275
Score = 43.9 bits (102), Expect = 7e-04
Identities = 26/119 (21%), Positives = 49/119 (41%), Gaps = 7/119 (5%)
Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
V RC G+P PT +W ++G + V ++ +L + P G Y+C
Sbjct: 86 VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 145
Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
+ +G + + L + + S R +L P + + F C+ + P +QW+
Sbjct: 146 NEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI 202
>gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
Length = 769
Score = 207 bits (526), Expect = 5e-53
Identities = 154/550 (28%), Positives = 253/550 (46%), Gaps = 60/550 (10%)
Query: 430 VTRDDAGNYTCIASNGPQGQIRAHVQLTVAV------FITFKVEPERTTVYQGHTALLQC 483
V D GNYTC+ N G I L V + + +TV G + C
Sbjct: 221 VVPSDKGNYTCVVEN-EYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV-C 278
Query: 484 EAQGDPKPLIQWKGKDRILDPTKLGPR--------MHIFQNGS----LVIHDVAPEDSGR 531
+ D +P IQW K + +K GP H N S L + +V D+G
Sbjct: 279 KVYSDAQPHIQWI-KHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGE 337
Query: 532 YTCIAGNSCNIKHTEAPLYVVDKP-VPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL 590
Y C N + A L V+ K P + + P Y I + V ++ V+
Sbjct: 338 YICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVI 397
Query: 591 GLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAAT 649
C+ K K+P+ +P + L Q + + ++ S T
Sbjct: 398 --------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRIT 449
Query: 650 NKRHSTSD----------------KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVA 693
+ ST+D K FPR L LG+ FG+V +A+A G+++
Sbjct: 450 TRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKP 509
Query: 694 ETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVD 749
+ V V KD+ + D E+EM + H N++ LLG C + P Y+++EY
Sbjct: 510 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 569
Query: 750 LGDLKQFLRISKSKD-------EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLA 802
G+L+++LR + ++ + ++ K V+ Q+A GME+L++ + +H+DLA
Sbjct: 570 KGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLA 629
Query: 803 ARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVWA 861
ARN LV+ +K++ GL++D+ N +YY +P++WM+PEA+ + ++ +SDVW+
Sbjct: 630 ARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 689
Query: 862 FGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDR 921
FGVLMWE+FT G P+ G +E+ L+ G R+ +P C ++LY +M+ CW P R
Sbjct: 690 FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPANCTNELYMMMRDCWHAVPSQR 748
Query: 922 PSFSEIASAL 931
P+F ++ L
Sbjct: 749 PTFKQLVEDL 758
Score = 55.5 bits (132), Expect = 2e-07
Identities = 54/222 (24%), Positives = 84/222 (37%), Gaps = 29/222 (13%)
Query: 329 EPRVFTA--GSEERVTCLPPKGLPEPSVW-WEHAGVRLPTHGRVYQKGHELVLANIAESD 385
+P V+ A G V CL L + +V W GV L + R G L + D
Sbjct: 46 QPEVYVAAPGESLEVRCL----LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRD 101
Query: 386 AGVYTCHAANLAGQRRQDVNITVANGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNG 445
+G+Y C A+ + V + S + D D A ++ SN
Sbjct: 102 SGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDT-----------DGAEDFVSENSNN 150
Query: 446 PQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDP 504
+ + + K+E V +T +C A G+P P ++W K
Sbjct: 151 KRAPYWTNTE---------KMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQE 201
Query: 505 TKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSC-NIKHT 545
++G Q+ SL++ V P D G YTC+ N +I HT
Sbjct: 202 HRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT 243
Score = 52.0 bits (123), Expect = 3e-06
Identities = 80/343 (23%), Positives = 119/343 (34%), Gaps = 78/343 (22%)
Query: 132 KHPASEAEIQ---PQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLR 188
K+ S+ E+ P + +RC + W +DG L G +N TV E L ++
Sbjct: 41 KYQISQPEVYVAAPGESLEVRCLLKD--AAVISWTKDGVHL--GPNNRTVLIGEY-LQIK 95
Query: 189 PAGPEHSGLYSCCAHSAFGQACSSQNFTLSIAD--------------ESF----ARVVLA 230
A P SGLY+C A + F +++ D E F + A
Sbjct: 96 GATPRDSGLYACTASRTVDS--ETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153
Query: 231 PQDVVVARYEEAM----------FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPH 274
P + E+ + F C P P+++WL F+ E I + R H
Sbjct: 154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 213
Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP-------- 326
SL++ V P + G Y C+ + + G + T HL +E P
Sbjct: 214 W---------SLIMESVVPSDKGNYTCVVENEYGS---INHTYHLDVVERSPHRPILQAG 261
Query: 327 LFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHA---GVRLPTHGRVYQK----------- 372
L G + C W +H G + G Y K
Sbjct: 262 LPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSN 321
Query: 373 GHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVANGSSLP 415
L L N+ E+DAG Y C +N GQ Q +TV P
Sbjct: 322 AEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAP 364
Score = 47.0 bits (110), Expect = 8e-05
Identities = 53/257 (20%), Positives = 87/257 (33%), Gaps = 41/257 (15%)
Query: 35 IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ 94
I QP A G +RC ++ + W DG + R G L +
Sbjct: 44 ISQPEVYVAAPGESLEVRCLLKDAAVIS--WTKDGVHLGPNNRTVLIGEYLQIKGATP-R 100
Query: 95 DSGTFQCVA------------------------RDDVTGEEARSANASFNIK---WIEAG 127
DSG + C A DD G E + S N + W
Sbjct: 101 DSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE 160
Query: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNL 185
+ + A A V RC G+P PT +W ++G + V ++ +L
Sbjct: 161 KMEKRLHAVPAA----NTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
Query: 186 TLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEA 242
+ P G Y+C + +G + + L + + S R +L P + +
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 274
Query: 243 MFHCQFSAQPPPSLQWL 259
F C+ + P +QW+
Sbjct: 275 EFVCKVYSDAQPHIQWI 291
>gi|221316638 fibroblast growth factor receptor 2 isoform 2
precursor [Homo sapiens]
Length = 822
Score = 207 bits (526), Expect = 5e-53
Identities = 154/550 (28%), Positives = 253/550 (46%), Gaps = 60/550 (10%)
Query: 430 VTRDDAGNYTCIASNGPQGQIRAHVQLTVAV------FITFKVEPERTTVYQGHTALLQC 483
V D GNYTC+ N G I L V + + +TV G + C
Sbjct: 221 VVPSDKGNYTCVVEN-EYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV-C 278
Query: 484 EAQGDPKPLIQWKGKDRILDPTKLGPR--------MHIFQNGS----LVIHDVAPEDSGR 531
+ D +P IQW K + +K GP H N S L + +V D+G
Sbjct: 279 KVYSDAQPHIQWI-KHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGE 337
Query: 532 YTCIAGNSCNIKHTEAPLYVVDKP-VPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL 590
Y C N + A L V+ K P + + P Y I + V ++ V+
Sbjct: 338 YICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVI 397
Query: 591 GLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAAT 649
C+ K K+P+ +P + L Q + + ++ S T
Sbjct: 398 --------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRIT 449
Query: 650 NKRHSTSD----------------KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVA 693
+ ST+D K FPR L LG+ FG+V +A+A G+++
Sbjct: 450 TRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKP 509
Query: 694 ETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVD 749
+ V V KD+ + D E+EM + H N++ LLG C + P Y+++EY
Sbjct: 510 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 569
Query: 750 LGDLKQFLRISKSKD-------EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLA 802
G+L+++LR + ++ + ++ K V+ Q+A GME+L++ + +H+DLA
Sbjct: 570 KGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLA 629
Query: 803 ARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVWA 861
ARN LV+ +K++ GL++D+ N +YY +P++WM+PEA+ + ++ +SDVW+
Sbjct: 630 ARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 689
Query: 862 FGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDR 921
FGVLMWE+FT G P+ G +E+ L+ G R+ +P C ++LY +M+ CW P R
Sbjct: 690 FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPANCTNELYMMMRDCWHAVPSQR 748
Query: 922 PSFSEIASAL 931
P+F ++ L
Sbjct: 749 PTFKQLVEDL 758
Score = 55.5 bits (132), Expect = 2e-07
Identities = 54/222 (24%), Positives = 84/222 (37%), Gaps = 29/222 (13%)
Query: 329 EPRVFTA--GSEERVTCLPPKGLPEPSVW-WEHAGVRLPTHGRVYQKGHELVLANIAESD 385
+P V+ A G V CL L + +V W GV L + R G L + D
Sbjct: 46 QPEVYVAAPGESLEVRCL----LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRD 101
Query: 386 AGVYTCHAANLAGQRRQDVNITVANGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNG 445
+G+Y C A+ + V + S + D D A ++ SN
Sbjct: 102 SGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDT-----------DGAEDFVSENSNN 150
Query: 446 PQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDP 504
+ + + K+E V +T +C A G+P P ++W K
Sbjct: 151 KRAPYWTNTE---------KMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQE 201
Query: 505 TKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSC-NIKHT 545
++G Q+ SL++ V P D G YTC+ N +I HT
Sbjct: 202 HRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHT 243
Score = 52.0 bits (123), Expect = 3e-06
Identities = 80/343 (23%), Positives = 119/343 (34%), Gaps = 78/343 (22%)
Query: 132 KHPASEAEIQ---PQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLR 188
K+ S+ E+ P + +RC + W +DG L G +N TV E L ++
Sbjct: 41 KYQISQPEVYVAAPGESLEVRCLLKD--AAVISWTKDGVHL--GPNNRTVLIGEY-LQIK 95
Query: 189 PAGPEHSGLYSCCAHSAFGQACSSQNFTLSIAD--------------ESF----ARVVLA 230
A P SGLY+C A + F +++ D E F + A
Sbjct: 96 GATPRDSGLYACTASRTVDS--ETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153
Query: 231 PQDVVVARYEEAM----------FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPH 274
P + E+ + F C P P+++WL F+ E I + R H
Sbjct: 154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 213
Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP-------- 326
SL++ V P + G Y C+ + + G + T HL +E P
Sbjct: 214 W---------SLIMESVVPSDKGNYTCVVENEYGS---INHTYHLDVVERSPHRPILQAG 261
Query: 327 LFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHA---GVRLPTHGRVYQK----------- 372
L G + C W +H G + G Y K
Sbjct: 262 LPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSN 321
Query: 373 GHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVANGSSLP 415
L L N+ E+DAG Y C +N GQ Q +TV P
Sbjct: 322 AEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAP 364
Score = 47.0 bits (110), Expect = 8e-05
Identities = 53/257 (20%), Positives = 87/257 (33%), Gaps = 41/257 (15%)
Query: 35 IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ 94
I QP A G +RC ++ + W DG + R G L +
Sbjct: 44 ISQPEVYVAAPGESLEVRCLLKDAAVIS--WTKDGVHLGPNNRTVLIGEYLQIKGATP-R 100
Query: 95 DSGTFQCVA------------------------RDDVTGEEARSANASFNIK---WIEAG 127
DSG + C A DD G E + S N + W
Sbjct: 101 DSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE 160
Query: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNL 185
+ + A A V RC G+P PT +W ++G + V ++ +L
Sbjct: 161 KMEKRLHAVPAA----NTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
Query: 186 TLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEA 242
+ P G Y+C + +G + + L + + S R +L P + +
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 274
Query: 243 MFHCQFSAQPPPSLQWL 259
F C+ + P +QW+
Sbjct: 275 EFVCKVYSDAQPHIQWI 291
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,966,938
Number of Sequences: 37866
Number of extensions: 2080689
Number of successful extensions: 14888
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 599
Number of HSP's successfully gapped in prelim test: 527
Number of HSP's that attempted gapping in prelim test: 5546
Number of HSP's gapped (non-prelim): 5041
length of query: 940
length of database: 18,247,518
effective HSP length: 112
effective length of query: 828
effective length of database: 14,006,526
effective search space: 11597403528
effective search space used: 11597403528
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.