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Search of human proteins with 22749379
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22749379 GRB2-binding adaptor protein, transmembrane [Homo
sapiens]
(157 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22749379 GRB2-binding adaptor protein, transmembrane [Homo sa... 329 5e-91
gi|148276990 zinc finger and BTB domain containing 38 [Homo sapi... 31 0.49
gi|29725609 epidermal growth factor receptor isoform a precursor... 30 0.65
gi|225690529 golgin, RAB6-interacting isoform a [Homo sapiens] 30 0.84
gi|225690532 golgin, RAB6-interacting isoform b [Homo sapiens] 30 0.84
gi|4502251 asialoglycoprotein receptor 1 [Homo sapiens] 30 0.84
gi|48255926 NADH-ubiquinone oxidoreductase flavoprotein 3 isofor... 29 1.4
gi|19913408 DNA topoisomerase II, beta isozyme [Homo sapiens] 28 2.5
gi|7662254 hephaestin isoform b [Homo sapiens] 28 3.2
gi|195963313 hephaestin isoform a [Homo sapiens] 28 3.2
gi|195947365 hephaestin isoform c [Homo sapiens] 28 3.2
gi|224809466 anthrax toxin receptor 2 isoform 2 [Homo sapiens] 28 4.2
gi|50513243 anthrax toxin receptor 2 isoform 1 [Homo sapiens] 28 4.2
gi|239749963 PREDICTED: MAS-related GPR, member G [Homo sapiens] 28 4.2
gi|239744271 PREDICTED: MAS-related GPR, member G [Homo sapiens] 28 4.2
gi|7330337 olfactory receptor, family 10, subfamily H, member 2 ... 28 4.2
gi|239582735 radial spoke head 4 homolog A isoform 2 [Homo sapiens] 27 5.5
gi|58219006 radial spoke head 4 homolog A isoform 1 [Homo sapiens] 27 5.5
gi|4504777 integrin, beta 7 [Homo sapiens] 27 5.5
gi|117414154 sodium channel associated protein 2 isoform b [Homo... 27 5.5
gi|117414162 sodium channel associated protein 2 isoform a [Homo... 27 5.5
gi|193788705 schlafen family member 14 [Homo sapiens] 27 7.1
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 27 9.3
gi|32967311 ephrin receptor EphA2 [Homo sapiens] 27 9.3
gi|239755468 PREDICTED: MAS-related GPR, member G [Homo sapiens] 27 9.3
>gi|22749379 GRB2-binding adaptor protein, transmembrane [Homo
sapiens]
Length = 157
Score = 329 bits (844), Expect = 5e-91
Identities = 157/157 (100%), Positives = 157/157 (100%)
Query: 1 MSKSCGNNLAAISVGISLLLLLVVCGIGCVWHWKHRVATRFTLPRFLQRRSSRRKVCTKT 60
MSKSCGNNLAAISVGISLLLLLVVCGIGCVWHWKHRVATRFTLPRFLQRRSSRRKVCTKT
Sbjct: 1 MSKSCGNNLAAISVGISLLLLLVVCGIGCVWHWKHRVATRFTLPRFLQRRSSRRKVCTKT 60
Query: 61 FLGPRIIGLRHEISVETQDHKSAVRGNNTHDNYENVEAGPPKAKGKTDKELYENTGQSNF 120
FLGPRIIGLRHEISVETQDHKSAVRGNNTHDNYENVEAGPPKAKGKTDKELYENTGQSNF
Sbjct: 61 FLGPRIIGLRHEISVETQDHKSAVRGNNTHDNYENVEAGPPKAKGKTDKELYENTGQSNF 120
Query: 121 EEHIYGNETSSDYYNFQKPRPSEVPQDEDIYILPDSY 157
EEHIYGNETSSDYYNFQKPRPSEVPQDEDIYILPDSY
Sbjct: 121 EEHIYGNETSSDYYNFQKPRPSEVPQDEDIYILPDSY 157
>gi|148276990 zinc finger and BTB domain containing 38 [Homo
sapiens]
Length = 1195
Score = 30.8 bits (68), Expect = 0.49
Identities = 25/96 (26%), Positives = 39/96 (40%), Gaps = 9/96 (9%)
Query: 57 CTKTFLGPRIIGLRHEISVETQDHKSAVRGNNTHDN-------YENVEAGPPKAKGKTDK 109
C +TF+ I+ H+ S DH+ ++ + Y+ P K K K
Sbjct: 521 CLETFMTYYILK-NHQKSFHAIDHRLSISKKTANGGLKPSVYPYKLYRLLPMKCKRAPYK 579
Query: 110 ELYENTGQSNFEEHIYGNETSSDYYNFQKPRPSEVP 145
Y N+ N E+ NE++ Y Q P SE+P
Sbjct: 580 S-YRNSSYENARENSQMNESAPGTYVVQNPHSSELP 614
>gi|29725609 epidermal growth factor receptor isoform a precursor
[Homo sapiens]
Length = 1210
Score = 30.4 bits (67), Expect = 0.65
Identities = 20/43 (46%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Query: 8 NLAAISVGISLLLLLVVCGIGCVWHWKHRVATRFTLPRFLQRR 50
++A VG LLLL+V GIG +H V R TL R LQ R
Sbjct: 645 SIATGMVGALLLLLVVALGIGLFMRRRHIVRKR-TLRRLLQER 686
>gi|225690529 golgin, RAB6-interacting isoform a [Homo sapiens]
Length = 394
Score = 30.0 bits (66), Expect = 0.84
Identities = 14/34 (41%), Positives = 20/34 (58%)
Query: 88 NTHDNYENVEAGPPKAKGKTDKELYENTGQSNFE 121
N+HD + NVE PPK K +K+ E +S +E
Sbjct: 139 NSHDGHNNVEILPPKPDCKLEKKKVELQEKSRWE 172
>gi|225690532 golgin, RAB6-interacting isoform b [Homo sapiens]
Length = 246
Score = 30.0 bits (66), Expect = 0.84
Identities = 14/34 (41%), Positives = 20/34 (58%)
Query: 88 NTHDNYENVEAGPPKAKGKTDKELYENTGQSNFE 121
N+HD + NVE PPK K +K+ E +S +E
Sbjct: 139 NSHDGHNNVEILPPKPDCKLEKKKVELQEKSRWE 172
>gi|4502251 asialoglycoprotein receptor 1 [Homo sapiens]
Length = 291
Score = 30.0 bits (66), Expect = 0.84
Identities = 14/23 (60%), Positives = 18/23 (78%)
Query: 6 GNNLAAISVGISLLLLLVVCGIG 28
G L +S+G+SLLLL+VVC IG
Sbjct: 38 GPRLLLLSLGLSLLLLVVVCVIG 60
>gi|48255926 NADH-ubiquinone oxidoreductase flavoprotein 3 isoform b
precursor [Homo sapiens]
Length = 108
Score = 29.3 bits (64), Expect = 1.4
Identities = 21/79 (26%), Positives = 33/79 (41%), Gaps = 9/79 (11%)
Query: 68 GLRHEISVETQDHKSAVRGNNTHDNYENVEAGPPKAKGKTDKELYENTGQSNFEEHIYGN 127
GL +S+ + KS +G + ++ PPK E ++NT N + H Y
Sbjct: 27 GLASTVSLSAESGKSE-KGQPQNSKKQS----PPKKPAPVPAEPFDNTTYKNLQHHDYST 81
Query: 128 ETSSD----YYNFQKPRPS 142
T D F+ P+PS
Sbjct: 82 YTFLDLNLELSKFRMPQPS 100
>gi|19913408 DNA topoisomerase II, beta isozyme [Homo sapiens]
Length = 1621
Score = 28.5 bits (62), Expect = 2.5
Identities = 17/57 (29%), Positives = 29/57 (50%), Gaps = 3/57 (5%)
Query: 101 PKAKGKTDKELYENTGQSNFEEHIYGNETSSDYYNFQKPRPSEVPQDEDIYILPDSY 157
PK KG+ K+ + +G N ++ G +TS +KP+ + QD D+ I P +
Sbjct: 1532 PKGKGRGAKKR-KASGSENEGDYNPGRKTSKT--TSKKPKKTSFDQDSDVDIFPSDF 1585
>gi|7662254 hephaestin isoform b [Homo sapiens]
Length = 891
Score = 28.1 bits (61), Expect = 3.2
Identities = 14/28 (50%), Positives = 20/28 (71%)
Query: 9 LAAISVGISLLLLLVVCGIGCVWHWKHR 36
LA++ V IS+ LLLVV +G V ++HR
Sbjct: 841 LASVLVAISVTLLLVVLALGGVVWYQHR 868
>gi|195963313 hephaestin isoform a [Homo sapiens]
Length = 1161
Score = 28.1 bits (61), Expect = 3.2
Identities = 14/28 (50%), Positives = 20/28 (71%)
Query: 9 LAAISVGISLLLLLVVCGIGCVWHWKHR 36
LA++ V IS+ LLLVV +G V ++HR
Sbjct: 1111 LASVLVAISVTLLLVVLALGGVVWYQHR 1138
>gi|195947365 hephaestin isoform c [Homo sapiens]
Length = 1160
Score = 28.1 bits (61), Expect = 3.2
Identities = 14/28 (50%), Positives = 20/28 (71%)
Query: 9 LAAISVGISLLLLLVVCGIGCVWHWKHR 36
LA++ V IS+ LLLVV +G V ++HR
Sbjct: 1110 LASVLVAISVTLLLVVLALGGVVWYQHR 1137
>gi|224809466 anthrax toxin receptor 2 isoform 2 [Homo sapiens]
Length = 489
Score = 27.7 bits (60), Expect = 4.2
Identities = 13/27 (48%), Positives = 19/27 (70%), Gaps = 3/27 (11%)
Query: 5 CGNNLAAISVGISLLLLLVVCGIGCVW 31
C N +AAI I +L+LL++ GIG +W
Sbjct: 315 CSNGIAAI---IVILVLLLLLGIGLMW 338
>gi|50513243 anthrax toxin receptor 2 isoform 1 [Homo sapiens]
Length = 488
Score = 27.7 bits (60), Expect = 4.2
Identities = 13/27 (48%), Positives = 19/27 (70%), Gaps = 3/27 (11%)
Query: 5 CGNNLAAISVGISLLLLLVVCGIGCVW 31
C N +AAI I +L+LL++ GIG +W
Sbjct: 315 CSNGIAAI---IVILVLLLLLGIGLMW 338
>gi|239749963 PREDICTED: MAS-related GPR, member G [Homo sapiens]
Length = 289
Score = 27.7 bits (60), Expect = 4.2
Identities = 12/31 (38%), Positives = 17/31 (54%)
Query: 16 ISLLLLLVVCGIGCVWHWKHRVATRFTLPRF 46
+ LLLL CG+ V++W + F LP F
Sbjct: 201 LGALLLLFFCGLPSVFYWSLQPLLNFLLPVF 231
>gi|239744271 PREDICTED: MAS-related GPR, member G [Homo sapiens]
Length = 289
Score = 27.7 bits (60), Expect = 4.2
Identities = 12/31 (38%), Positives = 17/31 (54%)
Query: 16 ISLLLLLVVCGIGCVWHWKHRVATRFTLPRF 46
+ LLLL CG+ V++W + F LP F
Sbjct: 201 LGALLLLFFCGLPSVFYWSLQPLLNFLLPVF 231
>gi|7330337 olfactory receptor, family 10, subfamily H, member 2
[Homo sapiens]
Length = 315
Score = 27.7 bits (60), Expect = 4.2
Identities = 8/23 (34%), Positives = 18/23 (78%)
Query: 4 SCGNNLAAISVGISLLLLLVVCG 26
+CGNN+ A+++G+ L+ ++ + G
Sbjct: 188 ACGNNVPAVALGVGLVCIMALLG 210
>gi|239582735 radial spoke head 4 homolog A isoform 2 [Homo sapiens]
Length = 600
Score = 27.3 bits (59), Expect = 5.5
Identities = 17/65 (26%), Positives = 26/65 (40%), Gaps = 5/65 (7%)
Query: 77 TQDHKSAVRGNNTHDNYENVEAGPPKAKGKTDKELYENTGQSNFEEHIYGNETSSDYYNF 136
T H S GN ++ + P G+ D Y N Q ++ E S+ Y+
Sbjct: 138 TPHHTSQSEGNT----FQQSQQPKPHLCGRRDVS-YNNAKQKELRFDVFQEEDSNSDYDL 192
Query: 137 QKPRP 141
Q+P P
Sbjct: 193 QQPAP 197
>gi|58219006 radial spoke head 4 homolog A isoform 1 [Homo sapiens]
Length = 716
Score = 27.3 bits (59), Expect = 5.5
Identities = 17/65 (26%), Positives = 26/65 (40%), Gaps = 5/65 (7%)
Query: 77 TQDHKSAVRGNNTHDNYENVEAGPPKAKGKTDKELYENTGQSNFEEHIYGNETSSDYYNF 136
T H S GN ++ + P G+ D Y N Q ++ E S+ Y+
Sbjct: 138 TPHHTSQSEGNT----FQQSQQPKPHLCGRRDVS-YNNAKQKELRFDVFQEEDSNSDYDL 192
Query: 137 QKPRP 141
Q+P P
Sbjct: 193 QQPAP 197
>gi|4504777 integrin, beta 7 [Homo sapiens]
Length = 798
Score = 27.3 bits (59), Expect = 5.5
Identities = 21/64 (32%), Positives = 31/64 (48%), Gaps = 10/64 (15%)
Query: 74 SVETQDHKSAVRGNNTHDNYENVEAGPPKAKGKTDKELYENTGQSNFEEHIYGNETSSDY 133
S T +H S G H +YE+ GP K +GK E+ GQ N H+ N+T + +
Sbjct: 391 STVTLEHSSLPPG--VHISYESQCEGPEKREGKA-----EDRGQCN---HVRINQTVTFW 440
Query: 134 YNFQ 137
+ Q
Sbjct: 441 VSLQ 444
>gi|117414154 sodium channel associated protein 2 isoform b [Homo
sapiens]
Length = 939
Score = 27.3 bits (59), Expect = 5.5
Identities = 23/79 (29%), Positives = 37/79 (46%), Gaps = 13/79 (16%)
Query: 69 LRHEISVETQDHKSAVRGNNTHDNYENVEAGPPKAKGKTDKELYENTGQSNFEEHIYGNE 128
L++EI ++ D + N T ++ +NV P+ K TD T +S+ YGN
Sbjct: 198 LQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTD-----ITSESD-----YGNR 247
Query: 129 TSSDYYNFQKPRPSEVPQD 147
N + PR S++P D
Sbjct: 248 KEC---NRKVPRRSKIPYD 263
>gi|117414162 sodium channel associated protein 2 isoform a [Homo
sapiens]
Length = 1032
Score = 27.3 bits (59), Expect = 5.5
Identities = 23/79 (29%), Positives = 37/79 (46%), Gaps = 13/79 (16%)
Query: 69 LRHEISVETQDHKSAVRGNNTHDNYENVEAGPPKAKGKTDKELYENTGQSNFEEHIYGNE 128
L++EI ++ D + N T ++ +NV P+ K TD T +S+ YGN
Sbjct: 291 LQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTD-----ITSESD-----YGNR 340
Query: 129 TSSDYYNFQKPRPSEVPQD 147
N + PR S++P D
Sbjct: 341 KEC---NRKVPRRSKIPYD 356
>gi|193788705 schlafen family member 14 [Homo sapiens]
Length = 912
Score = 26.9 bits (58), Expect = 7.1
Identities = 18/71 (25%), Positives = 38/71 (53%), Gaps = 4/71 (5%)
Query: 42 TLPRFLQRRSSRRKVCTKTFLGPRIIGLRHEISVETQDHKSAVRGNNTHDNYENVEAGPP 101
+L F+ ++++ + V KTF+ + ++H + ET++ S + N + +N+ P
Sbjct: 629 SLKDFVTQQTTCQAVTRKTFMQGEFLKIKHIVMDETENFCS--KYGNWYMKAKNIT--HP 684
Query: 102 KAKGKTDKELY 112
KAKG + L+
Sbjct: 685 KAKGTGSENLH 695
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 26.6 bits (57), Expect = 9.3
Identities = 13/50 (26%), Positives = 22/50 (44%)
Query: 108 DKELYENTGQSNFEEHIYGNETSSDYYNFQKPRPSEVPQDEDIYILPDSY 157
D E E+T +H + ET + + Q+ S P+ + +P SY
Sbjct: 1438 DSENEEDTPTPGLSDHFHSEETEEEETSPQEESVSPTPRSQPSSSVPSSY 1487
>gi|32967311 ephrin receptor EphA2 [Homo sapiens]
Length = 976
Score = 26.6 bits (57), Expect = 9.3
Identities = 18/65 (27%), Positives = 30/65 (46%), Gaps = 1/65 (1%)
Query: 1 MSKSCGNNLAAIS-VGISLLLLLVVCGIGCVWHWKHRVATRFTLPRFLQRRSSRRKVCTK 59
+S NLA I V + ++LLLV+ G+G H + + P + S + K
Sbjct: 527 LSPEGSGNLAVIGGVAVGVVLLLVLAGVGFFIHRRRKNQRARQSPEDVYFSKSEQLKPLK 586
Query: 60 TFLGP 64
T++ P
Sbjct: 587 TYVDP 591
>gi|239755468 PREDICTED: MAS-related GPR, member G [Homo sapiens]
Length = 289
Score = 26.6 bits (57), Expect = 9.3
Identities = 11/31 (35%), Positives = 17/31 (54%)
Query: 16 ISLLLLLVVCGIGCVWHWKHRVATRFTLPRF 46
+ LL+L CG+ V++W + F LP F
Sbjct: 201 LGALLVLFFCGLPSVFYWSLQPLLNFLLPVF 231
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 6,509,393
Number of Sequences: 37866
Number of extensions: 275137
Number of successful extensions: 712
Number of sequences better than 10.0: 25
Number of HSP's better than 10.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 697
Number of HSP's gapped (non-prelim): 25
length of query: 157
length of database: 18,247,518
effective HSP length: 94
effective length of query: 63
effective length of database: 14,688,114
effective search space: 925351182
effective search space used: 925351182
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 57 (26.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.