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Search of human proteins with 22749323
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22749323 mixed lineage kinase domain-like isoform 1 [Homo
sapiens]
(471 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22749323 mixed lineage kinase domain-like isoform 1 [Homo sap... 933 0.0
gi|215820622 mixed lineage kinase domain-like isoform 2 [Homo sa... 359 3e-99
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 105 1e-22
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 101 2e-21
gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho... 100 3e-21
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho... 98 2e-20
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 96 7e-20
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 96 7e-20
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 94 3e-19
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 94 3e-19
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 92 1e-18
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 92 1e-18
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens] 92 1e-18
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens] 92 1e-18
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 92 1e-18
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 92 1e-18
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 90 4e-18
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso... 90 4e-18
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso... 90 4e-18
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof... 90 4e-18
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 89 7e-18
gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinas... 88 2e-17
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 87 2e-17
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 87 2e-17
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 87 2e-17
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 87 2e-17
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 87 2e-17
gi|31657140 insulin receptor-related receptor precursor [Homo sa... 87 3e-17
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 84 3e-16
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 84 4e-16
>gi|22749323 mixed lineage kinase domain-like isoform 1 [Homo
sapiens]
Length = 471
Score = 933 bits (2412), Expect = 0.0
Identities = 471/471 (100%), Positives = 471/471 (100%)
Query: 1 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT 60
MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
Sbjct: 1 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT 60
Query: 61 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ 120
AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
Sbjct: 61 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ 120
Query: 121 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL 180
RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL
Sbjct: 121 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL 180
Query: 181 PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI 240
PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI
Sbjct: 181 PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI 240
Query: 241 AIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD 300
AIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD
Sbjct: 241 AIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD 300
Query: 301 LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS 360
LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS
Sbjct: 301 LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS 360
Query: 361 LGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKI 420
LGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKI
Sbjct: 361 LGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKI 420
Query: 421 RKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK 471
RKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
Sbjct: 421 RKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK 471
>gi|215820622 mixed lineage kinase domain-like isoform 2 [Homo
sapiens]
Length = 263
Score = 359 bits (921), Expect = 3e-99
Identities = 186/206 (90%), Positives = 190/206 (92%), Gaps = 3/206 (1%)
Query: 1 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT 60
MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
Sbjct: 1 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT 60
Query: 61 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ 120
AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
Sbjct: 61 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ 120
Query: 121 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL 180
RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQ L
Sbjct: 121 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQSL 180
Query: 181 PP---KCMQEIPQEQIKEIKKEQLSG 203
K EI + ++K +K SG
Sbjct: 181 ESSSGKSPLEISRFKVKNVKTGSASG 206
Score = 120 bits (300), Expect = 3e-27
Identities = 58/58 (100%), Positives = 58/58 (100%)
Query: 414 GCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK 471
GCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
Sbjct: 206 GCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK 263
>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
sapiens]
Length = 859
Score = 105 bits (261), Expect = 1e-22
Identities = 76/281 (27%), Positives = 130/281 (46%), Gaps = 26/281 (9%)
Query: 190 QEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNK 249
QE + E+ E++ W+ ++ G +H VA+K + L+
Sbjct: 114 QEDLWEVPFEEILDLQWV--GSGAQGAVFLGRFHGEEVAVKKVRDLK-----------ET 160
Query: 250 EIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRMVL 309
+IK ++K + PNI+ G+C P + I+ME+C G L E+L + +T +
Sbjct: 161 DIKHLRKLKHPNIITFKGVCTQA----PCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDW 216
Query: 310 VLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTD 369
+G A G+ LH + +H ++S N L+T VK++ F TS L K
Sbjct: 217 SMGIAGGMNYLHLHKI--IHRDLKSPNMLITYDDVVKISDFG-----TSKELSDKSTKMS 269
Query: 370 RVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQ 429
+ A+++P+ + + K +I+SFG+VLWE+ TG+IP++ +S I V
Sbjct: 270 FAGTVAWMAPEVIRNE--PVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL 327
Query: 430 QEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFS 470
P+ CP + ++ +C P RPS +IL L S
Sbjct: 328 HLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIAS 368
>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
sapiens]
Length = 847
Score = 101 bits (251), Expect = 2e-21
Identities = 73/262 (27%), Positives = 133/262 (50%), Gaps = 28/262 (10%)
Query: 217 LYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTP 276
+Y+G + VA+K ++ I++ ++ +E + PNI+ + +C++E
Sbjct: 131 VYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEE---- 186
Query: 277 PQFSIVMEYCELGTLRELLDREKDLTLGKRM---VLVLGA---ARGLYRLH-HSEAPELH 329
P +VMEY G L L G+R+ VLV A ARG++ LH + P +H
Sbjct: 187 PNLCLVMEYAAGGPLSRAL-------AGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIH 239
Query: 330 GKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTRE--KTDRVKST---AYLSPQELED 384
++S+N L+ Q ++ E KT G RE KT ++ + A+++P+ ++
Sbjct: 240 RDLKSNNILLLQ--PIESDDME-HKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKA 296
Query: 385 VFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREI 444
+ S+++SFG++LWE+ TG++P++G + + VAV + P+ CP ++
Sbjct: 297 STFSKG--SDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQL 354
Query: 445 IDECRAHDPSVRPSVDEILKKL 466
+ +C A DP RP IL++L
Sbjct: 355 MADCWAQDPHRRPDFASILQQL 376
>gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo
sapiens]
Length = 966
Score = 100 bits (249), Expect = 3e-21
Identities = 78/284 (27%), Positives = 129/284 (45%), Gaps = 26/284 (9%)
Query: 187 EIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQT 246
++ Q+ E+ E++S W L ++ G++ VAIK VR+
Sbjct: 154 KLQQQDTWEVPFEEISELQW--LGSGAQGAVFLGKFRAEEVAIKK-----------VREQ 200
Query: 247 FNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKR 306
+IK ++K + PNI+ G+C P + I+MEYC G L E+L + +T
Sbjct: 201 NETDIKHLRKLKHPNIIAFKGVCTQA----PCYCIIMEYCAHGQLYEVLRAGRKITPRLL 256
Query: 307 MVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTRE 366
+ G A G+ LH + +H ++S N LVT VK++ F TS L
Sbjct: 257 VDWSTGIASGMNYLHLHKI--IHRDLKSPNVLVTHTDAVKISDFG-----TSKELSDKST 309
Query: 367 KTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAV 426
K + A+++P+ + + K +I+SFG+VLWE+ TG+IP++ +S I V
Sbjct: 310 KMSFAGTVAWMAPEVIRNE--PVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGS 367
Query: 427 KRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFS 470
P+ CP + ++ + P RPS + L L S
Sbjct: 368 NSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIAS 411
>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
sapiens]
Length = 1118
Score = 97.8 bits (242), Expect = 2e-20
Identities = 70/265 (26%), Positives = 129/265 (48%), Gaps = 24/265 (9%)
Query: 217 LYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTP 276
+Y+ + VA+K + I+ + +E K + PNI+ + G+C+ E
Sbjct: 158 VYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKE---- 213
Query: 277 PQFSIVMEYCELGTLRELLDREKDLTLGKRM---VLVLGA---ARGLYRLHHSE-APELH 329
P +VME+ G L +L GKR+ +LV A ARG+ LH P +H
Sbjct: 214 PNLCLVMEFARGGPLNRVLS-------GKRIPPDILVNWAVQIARGMNYLHDEAIVPIIH 266
Query: 330 GKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKST---AYLSPQELEDVF 386
++SSN L+ Q + ++ K T L +T ++ + A+++P+ +
Sbjct: 267 RDLKSSNILILQKVENGDLSNKILKI-TDFGLAREWHRTTKMSAAGTYAWMAPEVIRASM 325
Query: 387 YQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIID 446
+ S+++S+G++LWE+ TG++PF+G + + VA+ + P+ CP ++++
Sbjct: 326 FSKG--SDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLME 383
Query: 447 ECRAHDPSVRPSVDEILKKLSTFSK 471
+C DP RPS IL +L+T +
Sbjct: 384 DCWNPDPHSRPSFTNILDQLTTIEE 408
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 95.9 bits (237), Expect = 7e-20
Identities = 71/272 (26%), Positives = 128/272 (47%), Gaps = 31/272 (11%)
Query: 217 LYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTP 276
+Y+ + VA+K ++ A ++ +E + PNI+ + G+C+ +
Sbjct: 138 VYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQ---- 193
Query: 277 PQFSIVMEYCELGTLRELL--------DREKDLTLGKRM---VLVLGA---ARGLYRLHH 322
P +V+E+ G L L R +R+ VLV A ARG+ LH
Sbjct: 194 PHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHE 253
Query: 323 SE-APELHGKIRSSNFLVTQGYQVKLAGFEL-RKTQTSMSLGTTRE-----KTDRVKSTA 375
P LH ++SSN L+ + K+ ++ KT G RE K + A
Sbjct: 254 EAFVPILHRDLKSSNILLLE----KIEHDDICNKTLKITDFGLAREWHRTTKMSTAGTYA 309
Query: 376 YLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGE 435
+++P+ ++ + S+I+S+G++LWE+ TG++P++G + + VAV + P+
Sbjct: 310 WMAPEVIKSSLFSKG--SDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPS 367
Query: 436 DCPSELREIIDECRAHDPSVRPSVDEILKKLS 467
CP +++ EC DP +RPS IL++L+
Sbjct: 368 TCPEPFAKLMKECWQQDPHIRPSFALILEQLT 399
>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
sapiens]
Length = 954
Score = 95.9 bits (237), Expect = 7e-20
Identities = 74/296 (25%), Positives = 138/296 (46%), Gaps = 32/296 (10%)
Query: 187 EIPQE-QIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQ 245
++PQE E++ E++ G +Y+ + VA+K + A+ +
Sbjct: 88 QLPQEIPFHELQLEEIIGV-------GGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAE 140
Query: 246 TFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDLTLGK 305
+E + + PNI+ + G C++ PP +VMEY G L +L G+
Sbjct: 141 QVCQEARLFGALQHPNIIALRGACLN----PPHLCLVMEYARGGALSRVL-------AGR 189
Query: 306 RM---VLVLGA---ARGLYRLHH-SEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTS 358
R+ VLV A ARG+ LH+ + P +H ++S N L+ + + + K T
Sbjct: 190 RVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKI-TD 248
Query: 359 MSLGTTREKTDRVKST---AYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGC 415
L KT ++ + A+++P+ + + S+++SFG++LWE+ TG++P++
Sbjct: 249 FGLAREWHKTTKMSAAGTYAWMAPEVIR--LSLFSKSSDVWSFGVLLWELLTGEVPYREI 306
Query: 416 NSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK 471
++ + VA+ + P+ CP +++EC DP RP ILK+L +
Sbjct: 307 DALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQ 362
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 93.6 bits (231), Expect = 3e-19
Identities = 70/279 (25%), Positives = 131/279 (46%), Gaps = 22/279 (7%)
Query: 192 QIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEI 251
Q+ EI+ ++ GS +YKG VAIK ++ S + V F +E+
Sbjct: 459 QLSEIEFHEIIGS-------GSFGKVYKGRCRNKIVAIKRYRANTYCSKSDV-DMFCREV 510
Query: 252 KTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD-LTLGKRMVLV 310
+ + P +++ G C+++ P QF+IV +Y G+L LL +K L L ++++
Sbjct: 511 SILCQLNHPCVIQFVGACLND---PSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIA 567
Query: 311 LGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDR 370
+ A+G+ LH+ P +H + S N L+ + +A F + S+ ++
Sbjct: 568 VDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGN 627
Query: 371 VKSTAYLSPQELEDVFYQ---YDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVK 427
++ +++P+ VF Q Y +K++++S+ + LWEI TG+IPF +A
Sbjct: 628 LR---WMAPE----VFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYH 680
Query: 428 RQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKL 466
+ P+G P + ++ P RP E++ KL
Sbjct: 681 HIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKL 719
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 93.6 bits (231), Expect = 3e-19
Identities = 70/279 (25%), Positives = 131/279 (46%), Gaps = 22/279 (7%)
Query: 192 QIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEI 251
Q+ EI+ ++ GS +YKG VAIK ++ S + V F +E+
Sbjct: 560 QLSEIEFHEIIGS-------GSFGKVYKGRCRNKIVAIKRYRANTYCSKSDV-DMFCREV 611
Query: 252 KTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD-LTLGKRMVLV 310
+ + P +++ G C+++ P QF+IV +Y G+L LL +K L L ++++
Sbjct: 612 SILCQLNHPCVIQFVGACLND---PSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIA 668
Query: 311 LGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDR 370
+ A+G+ LH+ P +H + S N L+ + +A F + S+ ++
Sbjct: 669 VDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGN 728
Query: 371 VKSTAYLSPQELEDVFYQ---YDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVK 427
++ +++P+ VF Q Y +K++++S+ + LWEI TG+IPF +A
Sbjct: 729 LR---WMAPE----VFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYH 781
Query: 428 RQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKL 466
+ P+G P + ++ P RP E++ KL
Sbjct: 782 HIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKL 820
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 92.0 bits (227), Expect = 1e-18
Identities = 72/255 (28%), Positives = 132/255 (51%), Gaps = 18/255 (7%)
Query: 217 LYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTP 276
+Y+G + + + + V K L+ ++ + + F KE MK+ + PN++++ G+C E
Sbjct: 256 VYEGVWKKYSLTVAV-KTLKEDTMEV--EEFLKEAAVMKEIKHPNLVQLLGVCTRE---- 308
Query: 277 PQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPE-LHGKIRSS 335
P F I+ E+ G L + L RE + +VL+ A + + + E +H + +
Sbjct: 309 PPFYIITEFMTYGNLLDYL-RECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAAR 367
Query: 336 NFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEI 395
N LV + + VK+A F L + T + +K TA P+ L + ++ +KS++
Sbjct: 368 NCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTA---PESL--AYNKFSIKSDV 422
Query: 396 YSFGIVLWEIAT-GDIPFQGCNSEKIRKLVAVK-RQQEPLGEDCPSELREIIDECRAHDP 453
++FG++LWEIAT G P+ G + ++ +L+ R + P E CP ++ E++ C +P
Sbjct: 423 WAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERP--EGCPEKVYELMRACWQWNP 480
Query: 454 SVRPSVDEILKKLST 468
S RPS EI + T
Sbjct: 481 SDRPSFAEIHQAFET 495
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 92.0 bits (227), Expect = 1e-18
Identities = 72/255 (28%), Positives = 132/255 (51%), Gaps = 18/255 (7%)
Query: 217 LYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTP 276
+Y+G + + + + V K L+ ++ + + F KE MK+ + PN++++ G+C E
Sbjct: 275 VYEGVWKKYSLTVAV-KTLKEDTMEV--EEFLKEAAVMKEIKHPNLVQLLGVCTRE---- 327
Query: 277 PQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPE-LHGKIRSS 335
P F I+ E+ G L + L RE + +VL+ A + + + E +H + +
Sbjct: 328 PPFYIITEFMTYGNLLDYL-RECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAAR 386
Query: 336 NFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEI 395
N LV + + VK+A F L + T + +K TA P+ L + ++ +KS++
Sbjct: 387 NCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTA---PESL--AYNKFSIKSDV 441
Query: 396 YSFGIVLWEIAT-GDIPFQGCNSEKIRKLVAVK-RQQEPLGEDCPSELREIIDECRAHDP 453
++FG++LWEIAT G P+ G + ++ +L+ R + P E CP ++ E++ C +P
Sbjct: 442 WAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERP--EGCPEKVYELMRACWQWNP 499
Query: 454 SVRPSVDEILKKLST 468
S RPS EI + T
Sbjct: 500 SDRPSFAEIHQAFET 514
>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
Length = 1074
Score = 92.0 bits (227), Expect = 1e-18
Identities = 82/290 (28%), Positives = 141/290 (48%), Gaps = 29/290 (10%)
Query: 188 IPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAP-----VAIKVFKKLQAGSIAI 242
+P + EI++E++ I E + +++G Y VAIK K + S
Sbjct: 431 MPSTRDYEIQRERIELGRCI--GEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDS--- 485
Query: 243 VRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLD-REKDL 301
VR+ F +E TM++F+ P+I+++ G+ + V I+ME C LG LR L R+ L
Sbjct: 486 VREKFLQEALTMRQFDHPHIVKLIGVITENPVW-----IIMELCTLGELRSFLQVRKYSL 540
Query: 302 TLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSL 361
L ++ + L L +H I + N LV+ VKL F L +
Sbjct: 541 DLASLILYAYQLSTALAYLESKRF--VHRDIAARNVLVSSNDCVKLGDFGLSRYMED--- 595
Query: 362 GTTREKTDRVK-STAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDI-PFQGC-NSE 418
+T K + K +++P+ + F ++ S+++ FG+ +WEI + PFQG N++
Sbjct: 596 -STYYKASKGKLPIKWMAPESIN--FRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNND 652
Query: 419 KIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLST 468
I ++ +R P+ +CP L ++ +C A+DPS RP E+ +LST
Sbjct: 653 VIGRIENGERL--PMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLST 700
>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
Length = 1052
Score = 92.0 bits (227), Expect = 1e-18
Identities = 82/290 (28%), Positives = 141/290 (48%), Gaps = 29/290 (10%)
Query: 188 IPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAP-----VAIKVFKKLQAGSIAI 242
+P + EI++E++ I E + +++G Y VAIK K + S
Sbjct: 409 MPSTRDYEIQRERIELGRCI--GEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDS--- 463
Query: 243 VRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLD-REKDL 301
VR+ F +E TM++F+ P+I+++ G+ + V I+ME C LG LR L R+ L
Sbjct: 464 VREKFLQEALTMRQFDHPHIVKLIGVITENPVW-----IIMELCTLGELRSFLQVRKYSL 518
Query: 302 TLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSL 361
L ++ + L L +H I + N LV+ VKL F L +
Sbjct: 519 DLASLILYAYQLSTALAYLESKRF--VHRDIAARNVLVSSNDCVKLGDFGLSRYMED--- 573
Query: 362 GTTREKTDRVK-STAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDI-PFQGC-NSE 418
+T K + K +++P+ + F ++ S+++ FG+ +WEI + PFQG N++
Sbjct: 574 -STYYKASKGKLPIKWMAPESIN--FRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNND 630
Query: 419 KIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLST 468
I ++ +R P+ +CP L ++ +C A+DPS RP E+ +LST
Sbjct: 631 VIGRIENGERL--PMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLST 678
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 92.0 bits (227), Expect = 1e-18
Identities = 59/229 (25%), Positives = 112/229 (48%), Gaps = 23/229 (10%)
Query: 249 KEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLD--REKDLTLGKR 306
KE + + NI++ +G+ ++ PP + IV EY LG+L + ++ R +++ +
Sbjct: 52 KEAEILSVLSHRNIIQFYGVILE----PPNYGIVTEYASLGSLYDYINSNRSEEMDMDHI 107
Query: 307 MVLVLGAARGLYRLHHSEAPE--LHGKIRSSNFLVTQGYQVKLAGF---ELRKTQTSMSL 361
M A+G++ LH EAP +H ++S N ++ +K+ F T MSL
Sbjct: 108 MTWATDVAKGMHYLH-MEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSL 166
Query: 362 GTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIR 421
V + +++P+ ++ + + YS+G+VLWE+ T ++PF+G ++
Sbjct: 167 ---------VGTFPWMAPEVIQSL--PVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVA 215
Query: 422 KLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFS 470
LV K ++ + CP E++ +C D RPS +I+ L + S
Sbjct: 216 WLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMS 264
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 92.0 bits (227), Expect = 1e-18
Identities = 59/229 (25%), Positives = 112/229 (48%), Gaps = 23/229 (10%)
Query: 249 KEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLD--REKDLTLGKR 306
KE + + NI++ +G+ ++ PP + IV EY LG+L + ++ R +++ +
Sbjct: 52 KEAEILSVLSHRNIIQFYGVILE----PPNYGIVTEYASLGSLYDYINSNRSEEMDMDHI 107
Query: 307 MVLVLGAARGLYRLHHSEAPE--LHGKIRSSNFLVTQGYQVKLAGF---ELRKTQTSMSL 361
M A+G++ LH EAP +H ++S N ++ +K+ F T MSL
Sbjct: 108 MTWATDVAKGMHYLH-MEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSL 166
Query: 362 GTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIR 421
V + +++P+ ++ + + YS+G+VLWE+ T ++PF+G ++
Sbjct: 167 ---------VGTFPWMAPEVIQSL--PVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVA 215
Query: 422 KLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFS 470
LV K ++ + CP E++ +C D RPS +I+ L + S
Sbjct: 216 WLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMS 264
>gi|21735566 mitogen-activated protein kinase kinase kinase 7
isoform D [Homo sapiens]
Length = 491
Score = 90.1 bits (222), Expect = 4e-18
Identities = 72/276 (26%), Positives = 125/276 (45%), Gaps = 32/276 (11%)
Query: 194 KEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKT 253
KEI+ E++ G + K ++ VAIK + R+ F E++
Sbjct: 34 KEIEVEEVVG-------RGAFGVVCKAKWRAKDVAIKQIESESE------RKAFIVELRQ 80
Query: 254 MKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDL---TLGKRMVLV 310
+ + PNI++++G C++ +VMEY E G+L +L + L T M
Sbjct: 81 LSRVNHPNIVKLYGACLNPVC------LVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWC 134
Query: 311 LGAARGLYRLHHSEAPEL-HGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTD 369
L ++G+ LH + L H ++ N L+ G G L+ + T+
Sbjct: 135 LQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAG------GTVLKICDFGTACDIQTHMTN 188
Query: 370 RVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKR- 428
S A+++P+ E Y K +++S+GI+LWE+ T PF R + AV
Sbjct: 189 NKGSAAWMAPEVFEGS--NYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNG 246
Query: 429 QQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILK 464
+ PL ++ P + ++ C + DPS RPS++EI+K
Sbjct: 247 TRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVK 282
>gi|21735564 mitogen-activated protein kinase kinase kinase 7
isoform C [Homo sapiens]
Length = 518
Score = 90.1 bits (222), Expect = 4e-18
Identities = 72/276 (26%), Positives = 125/276 (45%), Gaps = 32/276 (11%)
Query: 194 KEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKT 253
KEI+ E++ G + K ++ VAIK + R+ F E++
Sbjct: 34 KEIEVEEVVG-------RGAFGVVCKAKWRAKDVAIKQIESESE------RKAFIVELRQ 80
Query: 254 MKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDL---TLGKRMVLV 310
+ + PNI++++G C++ +VMEY E G+L +L + L T M
Sbjct: 81 LSRVNHPNIVKLYGACLNPVC------LVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWC 134
Query: 311 LGAARGLYRLHHSEAPEL-HGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTD 369
L ++G+ LH + L H ++ N L+ G G L+ + T+
Sbjct: 135 LQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAG------GTVLKICDFGTACDIQTHMTN 188
Query: 370 RVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKR- 428
S A+++P+ E Y K +++S+GI+LWE+ T PF R + AV
Sbjct: 189 NKGSAAWMAPEVFEGS--NYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNG 246
Query: 429 QQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILK 464
+ PL ++ P + ++ C + DPS RPS++EI+K
Sbjct: 247 TRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVK 282
>gi|21735562 mitogen-activated protein kinase kinase kinase 7
isoform B [Homo sapiens]
Length = 606
Score = 90.1 bits (222), Expect = 4e-18
Identities = 72/276 (26%), Positives = 125/276 (45%), Gaps = 32/276 (11%)
Query: 194 KEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKT 253
KEI+ E++ G + K ++ VAIK + R+ F E++
Sbjct: 34 KEIEVEEVVG-------RGAFGVVCKAKWRAKDVAIKQIESESE------RKAFIVELRQ 80
Query: 254 MKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDL---TLGKRMVLV 310
+ + PNI++++G C++ +VMEY E G+L +L + L T M
Sbjct: 81 LSRVNHPNIVKLYGACLNPVC------LVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWC 134
Query: 311 LGAARGLYRLHHSEAPEL-HGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTD 369
L ++G+ LH + L H ++ N L+ G G L+ + T+
Sbjct: 135 LQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAG------GTVLKICDFGTACDIQTHMTN 188
Query: 370 RVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKR- 428
S A+++P+ E Y K +++S+GI+LWE+ T PF R + AV
Sbjct: 189 NKGSAAWMAPEVFEGS--NYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNG 246
Query: 429 QQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILK 464
+ PL ++ P + ++ C + DPS RPS++EI+K
Sbjct: 247 TRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVK 282
>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
A [Homo sapiens]
Length = 579
Score = 90.1 bits (222), Expect = 4e-18
Identities = 72/276 (26%), Positives = 125/276 (45%), Gaps = 32/276 (11%)
Query: 194 KEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKT 253
KEI+ E++ G + K ++ VAIK + R+ F E++
Sbjct: 34 KEIEVEEVVG-------RGAFGVVCKAKWRAKDVAIKQIESESE------RKAFIVELRQ 80
Query: 254 MKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDL---TLGKRMVLV 310
+ + PNI++++G C++ +VMEY E G+L +L + L T M
Sbjct: 81 LSRVNHPNIVKLYGACLNPVC------LVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWC 134
Query: 311 LGAARGLYRLHHSEAPEL-HGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTD 369
L ++G+ LH + L H ++ N L+ G G L+ + T+
Sbjct: 135 LQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAG------GTVLKICDFGTACDIQTHMTN 188
Query: 370 RVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKR- 428
S A+++P+ E Y K +++S+GI+LWE+ T PF R + AV
Sbjct: 189 NKGSAAWMAPEVFEGS--NYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNG 246
Query: 429 QQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILK 464
+ PL ++ P + ++ C + DPS RPS++EI+K
Sbjct: 247 TRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVK 282
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 89.4 bits (220), Expect = 7e-18
Identities = 72/267 (26%), Positives = 133/267 (49%), Gaps = 18/267 (6%)
Query: 208 LLRENEVSTLYKGEYH-RAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIF 266
LL + +YKG + VA+K K+ + I F +E K +K+++ PNI+++
Sbjct: 568 LLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKI---KFLQEAKILKQYDHPNIVKLI 624
Query: 267 GICIDETVTPPQFSIVMEYCELGTLRELLDREKD-LTLGKRMVLVLGAARGLYRLHHSEA 325
G+C T P + I+ME G L R+KD L L + + L AA G+ L
Sbjct: 625 GVC---TQRQPVY-IIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGMLYLESKNC 680
Query: 326 PELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDV 385
+H + + N LV + +K++ F + + + ++ K +K TA P+ L
Sbjct: 681 --IHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTA---PEALN-- 733
Query: 386 FYQYDVKSEIYSFGIVLWE-IATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREI 444
+ +Y +S+++SFGI+LWE + G P+ G +++ R+ V + + + CP ++ +I
Sbjct: 734 YGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVE-RGYRMSAPQHCPEDISKI 792
Query: 445 IDECRAHDPSVRPSVDEILKKLSTFSK 471
+ +C + P RP E+ K+L+ +
Sbjct: 793 MMKCWDYKPENRPKFSELQKELTIIKR 819
>gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinase 1
[Homo sapiens]
Length = 671
Score = 87.8 bits (216), Expect = 2e-17
Identities = 67/262 (25%), Positives = 116/262 (44%), Gaps = 22/262 (8%)
Query: 222 YHRAPVAIKVFKKLQAGSIAIVR-QTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFS 280
+HR + + K + G I + +E K M + ++++ G+ I+E ++S
Sbjct: 35 FHRTQ-GLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEG----KYS 89
Query: 281 IVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVT 340
+VMEY E G L +L E L + ++L G+ LH +H ++ N LV
Sbjct: 90 LVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGV--IHKDLKPENILVD 147
Query: 341 QGYQVKLAGFELRKTQTSMSLGTTREKTDR-VKSTA--------YLSPQELEDVFYQYDV 391
+ +K+A L + L R V TA Y++P+ L DV +
Sbjct: 148 NDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTE 207
Query: 392 KSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEP----LGEDCPSELREIIDE 447
KS++YSF +VLW I P++ E+ + ++ +K P + E CP E+ ++
Sbjct: 208 KSDVYSFAVVLWAIFANKEPYENAICEQ-QLIMCIKSGNRPDVDDITEYCPREIISLMKL 266
Query: 448 CRAHDPSVRPSVDEILKKLSTF 469
C +P RP+ I +K F
Sbjct: 267 CWEANPEARPTFPGIEEKFRPF 288
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 87.4 bits (215), Expect = 2e-17
Identities = 73/255 (28%), Positives = 130/255 (50%), Gaps = 18/255 (7%)
Query: 217 LYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTP 276
+Y G + + + + V K L+ ++ + + F KE MK+ + PN++++ G+C T+ P
Sbjct: 287 VYVGVWKKYSLTVAV-KTLKEDTMEV--EEFLKEAAVMKEIKHPNLVQLLGVC---TLEP 340
Query: 277 PQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPE-LHGKIRSS 335
P F IV EY G L + L RE + +VL+ A + + + E +H + +
Sbjct: 341 P-FYIVTEYMPYGNLLDYL-RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAAR 398
Query: 336 NFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEI 395
N LV + + VK+A F L + T + +K TA P+ L + + +KS++
Sbjct: 399 NCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTA---PESL--AYNTFSIKSDV 453
Query: 396 YSFGIVLWEIAT-GDIPFQGCNSEKIRKLVAV-KRQQEPLGEDCPSELREIIDECRAHDP 453
++FG++LWEIAT G P+ G + ++ L+ R ++P E CP ++ E++ C P
Sbjct: 454 WAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQP--EGCPPKVYELMRACWKWSP 511
Query: 454 SVRPSVDEILKKLST 468
+ RPS E + T
Sbjct: 512 ADRPSFAETHQAFET 526
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 87.4 bits (215), Expect = 2e-17
Identities = 73/255 (28%), Positives = 130/255 (50%), Gaps = 18/255 (7%)
Query: 217 LYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTP 276
+Y G + + + + V K L+ ++ + + F KE MK+ + PN++++ G+C T+ P
Sbjct: 302 VYVGVWKKYSLTVAV-KTLKEDTMEV--EEFLKEAAVMKEIKHPNLVQLLGVC---TLEP 355
Query: 277 PQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPE-LHGKIRSS 335
P F IV EY G L + L RE + +VL+ A + + + E +H + +
Sbjct: 356 P-FYIVTEYMPYGNLLDYL-RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAAR 413
Query: 336 NFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEI 395
N LV + + VK+A F L + T + +K TA P+ L + + +KS++
Sbjct: 414 NCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTA---PESL--AYNTFSIKSDV 468
Query: 396 YSFGIVLWEIAT-GDIPFQGCNSEKIRKLVAV-KRQQEPLGEDCPSELREIIDECRAHDP 453
++FG++LWEIAT G P+ G + ++ L+ R ++P E CP ++ E++ C P
Sbjct: 469 WAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQP--EGCPPKVYELMRACWKWSP 526
Query: 454 SVRPSVDEILKKLST 468
+ RPS E + T
Sbjct: 527 ADRPSFAETHQAFET 541
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 87.4 bits (215), Expect = 2e-17
Identities = 73/255 (28%), Positives = 130/255 (50%), Gaps = 18/255 (7%)
Query: 217 LYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTP 276
+Y G + + + + V K L+ ++ + + F KE MK+ + PN++++ G+C T+ P
Sbjct: 281 VYVGVWKKYSLTVAV-KTLKEDTMEV--EEFLKEAAVMKEIKHPNLVQLLGVC---TLEP 334
Query: 277 PQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPE-LHGKIRSS 335
P F IV EY G L + L RE + +VL+ A + + + E +H + +
Sbjct: 335 P-FYIVTEYMPYGNLLDYL-RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAAR 392
Query: 336 NFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEI 395
N LV + + VK+A F L + T + +K TA P+ L + + +KS++
Sbjct: 393 NCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTA---PESL--AYNTFSIKSDV 447
Query: 396 YSFGIVLWEIAT-GDIPFQGCNSEKIRKLVAV-KRQQEPLGEDCPSELREIIDECRAHDP 453
++FG++LWEIAT G P+ G + ++ L+ R ++P E CP ++ E++ C P
Sbjct: 448 WAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQP--EGCPPKVYELMRACWKWSP 505
Query: 454 SVRPSVDEILKKLST 468
+ RPS E + T
Sbjct: 506 ADRPSFAETHQAFET 520
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 87.4 bits (215), Expect = 2e-17
Identities = 73/255 (28%), Positives = 130/255 (50%), Gaps = 18/255 (7%)
Query: 217 LYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTP 276
+Y G + + + + V K L+ ++ + + F KE MK+ + PN++++ G+C T+ P
Sbjct: 287 VYVGVWKKYSLTVAV-KTLKEDTMEV--EEFLKEAAVMKEIKHPNLVQLLGVC---TLEP 340
Query: 277 PQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPE-LHGKIRSS 335
P F IV EY G L + L RE + +VL+ A + + + E +H + +
Sbjct: 341 P-FYIVTEYMPYGNLLDYL-RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAAR 398
Query: 336 NFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEI 395
N LV + + VK+A F L + T + +K TA P+ L + + +KS++
Sbjct: 399 NCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTA---PESL--AYNTFSIKSDV 453
Query: 396 YSFGIVLWEIAT-GDIPFQGCNSEKIRKLVAV-KRQQEPLGEDCPSELREIIDECRAHDP 453
++FG++LWEIAT G P+ G + ++ L+ R ++P E CP ++ E++ C P
Sbjct: 454 WAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQP--EGCPPKVYELMRACWKWSP 511
Query: 454 SVRPSVDEILKKLST 468
+ RPS E + T
Sbjct: 512 ADRPSFAETHQAFET 526
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 87.4 bits (215), Expect = 2e-17
Identities = 73/255 (28%), Positives = 130/255 (50%), Gaps = 18/255 (7%)
Query: 217 LYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTP 276
+Y G + + + + V K L+ ++ + + F KE MK+ + PN++++ G+C T+ P
Sbjct: 266 VYVGVWKKYSLTVAV-KTLKEDTMEV--EEFLKEAAVMKEIKHPNLVQLLGVC---TLEP 319
Query: 277 PQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPE-LHGKIRSS 335
P F IV EY G L + L RE + +VL+ A + + + E +H + +
Sbjct: 320 P-FYIVTEYMPYGNLLDYL-RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAAR 377
Query: 336 NFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEI 395
N LV + + VK+A F L + T + +K TA P+ L + + +KS++
Sbjct: 378 NCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTA---PESL--AYNTFSIKSDV 432
Query: 396 YSFGIVLWEIAT-GDIPFQGCNSEKIRKLVAV-KRQQEPLGEDCPSELREIIDECRAHDP 453
++FG++LWEIAT G P+ G + ++ L+ R ++P E CP ++ E++ C P
Sbjct: 433 WAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQP--EGCPPKVYELMRACWKWSP 490
Query: 454 SVRPSVDEILKKLST 468
+ RPS E + T
Sbjct: 491 ADRPSFAETHQAFET 505
>gi|31657140 insulin receptor-related receptor precursor [Homo
sapiens]
Length = 1297
Score = 87.0 bits (214), Expect = 3e-17
Identities = 78/291 (26%), Positives = 138/291 (47%), Gaps = 28/291 (9%)
Query: 187 EIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQT 246
E+P+EQI I+ +L + ++ E L GE PVA+K +L + I
Sbjct: 973 EVPREQISIIR--ELGQGSFGMVYEGLARGLEAGE-ESTPVALKTVNELASPRECI---E 1026
Query: 247 FNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREK------- 299
F KE MK F+ +++R+ G+ T ++ME G L+ L +
Sbjct: 1027 FLKEASVMKAFKCHHVVRLLGVVSQGQPT----LVIMELMTRGDLKSHLRSLRPEAENNP 1082
Query: 300 ---DLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQ 356
LG+ + + A G+ L ++ +H + + N +V+Q + VK+ F + T+
Sbjct: 1083 GLPQPALGEMIQMAGEIADGMAYLAANKF--VHRDLAARNCMVSQDFTVKIGDFGM--TR 1138
Query: 357 TSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIAT-GDIPFQGC 415
R+ + +++P+ L+D + S+++SFG+VLWEI T + P+QG
Sbjct: 1139 DVYETDYYRKGGKGLLPVRWMAPESLKDGIFT--THSDVWSFGVVLWEIVTLAEQPYQGL 1196
Query: 416 NSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKL 466
++E++ K V E L E CP +L+E++ C +P +RPS IL +
Sbjct: 1197 SNEQVLKFVMDGGVLEEL-EGCPLQLQELMSRCWQPNPRLRPSFTHILDSI 1246
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 84.0 bits (206), Expect = 3e-16
Identities = 88/385 (22%), Positives = 167/385 (43%), Gaps = 38/385 (9%)
Query: 98 FKDVNRKLSDVWKELSLLLQVEQRMP---VSPIS--QGASWAQEDQQDADEDRRAFQMLR 152
F+ +N D W+ SL +P V+P+ Q W D +R Q+L
Sbjct: 109 FQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAER---QLLS 165
Query: 153 RDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQEQIKEIKKEQLSGSPWILLREN 212
N + +R E ++R + ++ + +K K +L + +
Sbjct: 166 FGNPRGTFLIRESETTKGAYSLSIRDW------DDMKGDHVKHYKIRKLDNGGYYITTRA 219
Query: 213 EVSTL------YKGEYH-RAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRI 265
+ TL Y G ++ VAIK K G+++ ++F +E + MKK + ++++
Sbjct: 220 QFETLQQLVQHYSGTWNGNTKVAIKTLKP---GTMS--PESFLEEAQIMKKLKHDKLVQL 274
Query: 266 FGICIDETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEA 325
+ + +E + IV EY G+L + L + L ++ + A +
Sbjct: 275 YAVVSEEPIY-----IVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM 329
Query: 326 PELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDV 385
+H +RS+N LV G K+A F L + + +K TA P+ +
Sbjct: 330 NYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTA---PEAA--L 384
Query: 386 FYQYDVKSEIYSFGIVLWEIAT-GDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREI 444
+ ++ +KS+++SFGI+L E+ T G +P+ G N+ ++ + V + + P +DCP L E+
Sbjct: 385 YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE-RGYRMPCPQDCPISLHEL 443
Query: 445 IDECRAHDPSVRPSVDEILKKLSTF 469
+ C DP RP+ + + L +
Sbjct: 444 MIHCWKKDPEERPTFEYLQSFLEDY 468
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 83.6 bits (205), Expect = 4e-16
Identities = 66/225 (29%), Positives = 100/225 (44%), Gaps = 14/225 (6%)
Query: 244 RQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDLTL 303
R +E K M+ + IL ++GIC + +VMEY E G+L +LL E L
Sbjct: 63 RMELLEEAKKMEMAKFRYILPVYGICREPV------GLVMEYMETGSLEKLLASEP-LPW 115
Query: 304 GKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGT 363
R ++ A G+ LH P LH ++ +N L+ Y VK++ F L K +S
Sbjct: 116 DLRFRIIHETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKCN-GLSHSH 174
Query: 364 TREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKL 423
+ AYL P+ + + +D K ++YSF IV+W + T PF + +
Sbjct: 175 DLSMDGLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMV 234
Query: 424 VAVKRQQEPLGEDCP------SELREIIDECRAHDPSVRPSVDEI 462
VK + L C S L ++ C DP VRP+ EI
Sbjct: 235 KVVKGHRPELPPVCRARPRACSHLIRLMQRCWQGDPRVRPTFQEI 279
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,150,892
Number of Sequences: 37866
Number of extensions: 748094
Number of successful extensions: 3875
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 189
Number of HSP's successfully gapped in prelim test: 424
Number of HSP's that attempted gapping in prelim test: 3099
Number of HSP's gapped (non-prelim): 775
length of query: 471
length of database: 18,247,518
effective HSP length: 106
effective length of query: 365
effective length of database: 14,233,722
effective search space: 5195308530
effective search space used: 5195308530
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.