BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|227116325 kringle-containing transmembrane protein 1 isoform 3 precursor [Homo sapiens] (458 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|227116325 kringle-containing transmembrane protein 1 isoform ... 969 0.0 gi|24041012 kringle-containing transmembrane protein 1 isoform 2... 952 0.0 gi|27437008 kringle-containing transmembrane protein 2 isoform d... 328 6e-90 gi|13375642 kringle-containing transmembrane protein 2 isoform b... 327 1e-89 gi|4758502 hyaluronan binding protein 2 preproprotein [Homo sapi... 84 3e-16 gi|4505861 plasminogen activator, tissue isoform 1 preproprotein... 84 3e-16 gi|14702169 plasminogen activator, tissue isoform 3 preproprotei... 84 3e-16 gi|4504383 HGF activator preproprotein [Homo sapiens] 75 9e-14 gi|4505881 plasminogen [Homo sapiens] 70 4e-12 gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 69 9e-12 gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 69 9e-12 gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 69 9e-12 gi|116292750 lipoprotein Lp(a) precursor [Homo sapiens] 69 1e-11 gi|58533165 hepatocyte growth factor isoform 4 precursor [Homo s... 68 2e-11 gi|58533163 hepatocyte growth factor isoform 2 precursor [Homo s... 68 2e-11 gi|145275213 coagulation factor XII precursor [Homo sapiens] 68 2e-11 gi|22035663 lipoprotein, Lp(a)-like 2 precursor [Homo sapiens] 67 3e-11 gi|13346502 lipoprotein, Lp(a)-like 2 precursor [Homo sapiens] 67 3e-11 gi|58533170 hepatocyte growth factor isoform 3 precursor [Homo s... 67 3e-11 gi|33859835 hepatocyte growth factor isoform 1 preproprotein [Ho... 67 3e-11 gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 65 1e-10 gi|26051243 tumor necrosis factor, alpha-induced protein 6 precu... 65 1e-10 gi|222537759 plasminogen activator, urokinase isoform 2 [Homo sa... 63 5e-10 gi|4505863 plasminogen activator, urokinase isoform 1 preproprot... 63 5e-10 gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 63 5e-10 gi|134152686 receptor tyrosine kinase-like orphan receptor 1 iso... 62 1e-09 gi|134152725 receptor tyrosine kinase-like orphan receptor 1 iso... 62 1e-09 gi|205277383 macrophage stimulating 1 (hepatocyte growth factor-... 62 1e-09 gi|19743898 receptor tyrosine kinase-like orphan receptor 2 prec... 60 4e-09 gi|54792094 WSC domain containing 1 [Homo sapiens] 54 4e-07 >gi|227116325 kringle-containing transmembrane protein 1 isoform 3 precursor [Homo sapiens] Length = 458 Score = 969 bits (2504), Expect = 0.0 Identities = 458/458 (100%), Positives = 458/458 (100%) Query: 1 MAPPAARLALLSAAALTLAARPAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFW 60 MAPPAARLALLSAAALTLAARPAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFW Sbjct: 1 MAPPAARLALLSAAALTLAARPAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFW 60 Query: 61 NETFQHPYNTLKYPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPACQMPG 120 NETFQHPYNTLKYPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPACQMPG Sbjct: 61 NETFQHPYNTLKYPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPACQMPG 120 Query: 121 NLGCYKDHGNPPPLTGTSKTSNKLTIQTCISFCRSQRFKFAGMESGYACFCGNNPDYWKY 180 NLGCYKDHGNPPPLTGTSKTSNKLTIQTCISFCRSQRFKFAGMESGYACFCGNNPDYWKY Sbjct: 121 NLGCYKDHGNPPPLTGTSKTSNKLTIQTCISFCRSQRFKFAGMESGYACFCGNNPDYWKY 180 Query: 181 GEAASTECNSVCFGDHTQPCGGDGRIILFDTLVGACGGNYSAMSSVVYSPDFPDTYATGR 240 GEAASTECNSVCFGDHTQPCGGDGRIILFDTLVGACGGNYSAMSSVVYSPDFPDTYATGR Sbjct: 181 GEAASTECNSVCFGDHTQPCGGDGRIILFDTLVGACGGNYSAMSSVVYSPDFPDTYATGR 240 Query: 241 VCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDGYTHRVLARFHGRSRPPLSFNVSLDF 300 VCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDGYTHRVLARFHGRSRPPLSFNVSLDF Sbjct: 241 VCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDGYTHRVLARFHGRSRPPLSFNVSLDF 300 Query: 301 VILYFFSDRINQAQGFAVLYQAVKEELPQERPAVNQTVAEVITEQANLSVSAARSSKVLY 360 VILYFFSDRINQAQGFAVLYQAVKEELPQERPAVNQTVAEVITEQANLSVSAARSSKVLY Sbjct: 301 VILYFFSDRINQAQGFAVLYQAVKEELPQERPAVNQTVAEVITEQANLSVSAARSSKVLY 360 Query: 361 VITTSPSHPPQTVPGWTVYGLATLLILTVTAIVAKILLHVTFKSHRVPASGDLRDCHQPG 420 VITTSPSHPPQTVPGWTVYGLATLLILTVTAIVAKILLHVTFKSHRVPASGDLRDCHQPG Sbjct: 361 VITTSPSHPPQTVPGWTVYGLATLLILTVTAIVAKILLHVTFKSHRVPASGDLRDCHQPG 420 Query: 421 TSGEIWSIFYKPSTSISIFKKKLKGQSQQDDRNPLVSD 458 TSGEIWSIFYKPSTSISIFKKKLKGQSQQDDRNPLVSD Sbjct: 421 TSGEIWSIFYKPSTSISIFKKKLKGQSQQDDRNPLVSD 458 >gi|24041012 kringle-containing transmembrane protein 1 isoform 2 precursor [Homo sapiens] Length = 492 Score = 952 bits (2462), Expect = 0.0 Identities = 455/472 (96%), Positives = 455/472 (96%), Gaps = 17/472 (3%) Query: 1 MAPPAARLALLSAAALTLAARPAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFW 60 MAPPAARLALLSAAALTLAARPAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFW Sbjct: 1 MAPPAARLALLSAAALTLAARPAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFW 60 Query: 61 NETFQHPYNTLKYPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPACQMPG 120 NETFQHPYNTLKYPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPACQMPG Sbjct: 61 NETFQHPYNTLKYPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPACQMPG 120 Query: 121 NLGCYKDHGNPPPLTGTSKTSNKLTIQTCISFCRSQRFKFAGMESGYACFCGNNPDYWKY 180 NLGCYKDHGNPPPLTGTSKTSNKLTIQTCISFCRSQRFKFAGMESGYACFCGNNPDYWKY Sbjct: 121 NLGCYKDHGNPPPLTGTSKTSNKLTIQTCISFCRSQRFKFAGMESGYACFCGNNPDYWKY 180 Query: 181 GEAASTECNSVCFGDHTQPCGGDGRIILFDTLVGACGGNYSAMSSVVYSPDFPDTYATGR 240 GEAASTECNSVCFGDHTQPCGGDGRIILFDTLVGACGGNYSAMSSVVYSPDFPDTYATGR Sbjct: 181 GEAASTECNSVCFGDHTQPCGGDGRIILFDTLVGACGGNYSAMSSVVYSPDFPDTYATGR 240 Query: 241 VCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDGYTHRVLARFHGRSRPPLSFNVSLDF 300 VCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDGYTHRVLARFHGRSRPPLSFNVSLDF Sbjct: 241 VCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDGYTHRVLARFHGRSRPPLSFNVSLDF 300 Query: 301 VILYFFSDRINQAQGFAVLYQAVKEELPQERPAVNQTVAEVITEQANLSVSAARSSKVLY 360 VILYFFSDRINQAQGFAVLYQAVKEELPQERPAVNQTVAEVITEQANLSVSAARSSKVLY Sbjct: 301 VILYFFSDRINQAQGFAVLYQAVKEELPQERPAVNQTVAEVITEQANLSVSAARSSKVLY 360 Query: 361 VITTSPSHPPQTVP-----------------GWTVYGLATLLILTVTAIVAKILLHVTFK 403 VITTSPSHPPQTVP GWTVYGLATLLILTVTAIVAKILLHVTFK Sbjct: 361 VITTSPSHPPQTVPGSNSWAPPMGAGSHRVEGWTVYGLATLLILTVTAIVAKILLHVTFK 420 Query: 404 SHRVPASGDLRDCHQPGTSGEIWSIFYKPSTSISIFKKKLKGQSQQDDRNPL 455 SHRVPASGDLRDCHQPGTSGEIWSIFYKPSTSISIFKKKLKGQSQQDDRNPL Sbjct: 421 SHRVPASGDLRDCHQPGTSGEIWSIFYKPSTSISIFKKKLKGQSQQDDRNPL 472 >gi|27437008 kringle-containing transmembrane protein 2 isoform d precursor [Homo sapiens] Length = 462 Score = 328 bits (841), Expect = 6e-90 Identities = 172/379 (45%), Positives = 234/379 (61%), Gaps = 31/379 (8%) Query: 25 SPGLGPGPECFTANGADYRGTQNWTALQG-GKPCLFWNETFQHPYNTLKYPNGEGGLGEH 83 SPGL ECF NGADYRG QN T +G G+PCLFW++T QH Y++ P+G GLG H Sbjct: 30 SPGLS---ECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAH 86 Query: 84 NYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPACQMPGNLGCYKDHGNPPPLTGTSKTSNK 143 N+CRNPDGDV PWCYVAE E+G+YW+YC+IP+C MPG LGC+ D G PP L+G S TS K Sbjct: 87 NFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSCHMPGYLGCFVDSGAPPALSGPSGTSTK 146 Query: 144 LTIQTCISFCRSQRFKFAGMESGYACFCGNNPDYWKYGEAASTECNSVCFGDHTQPCGGD 203 LT+Q C+ FCR + ++ AG+E+GYACFCG+ D + A +T+C+ +CFG Q CGGD Sbjct: 147 LTVQVCLRFCRMKGYQLAGVEAGYACFCGSESDLARGRLAPATDCDQICFGHPGQLCGGD 206 Query: 204 GRIILFDTLVGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDI 263 GR+ +++ VG+C GN++A V+YSPDFPD Y R C W + PGA+ + +F LF++ Sbjct: 207 GRLGVYEVSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALGPPGAA-LELTFRLFEL 265 Query: 264 RDSADMVELLDGYTHRVLARFHGRSRPPLS--FNVSLDFVILYFFSDRINQAQGFAVLYQ 321 D D +EL D + +L F G +RPP S + ++L F SD AQGFA+ Y+ Sbjct: 266 ADPRDRLELRDAASGSLLRAFDG-ARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYR 324 Query: 322 AVKE--ELPQERPAVNQTVAEVITEQANLSVSAARSSKVLYVITTSPSHPPQTVPGWTVY 379 +++ E P+ QT A + + AN+S S P PP + G V+ Sbjct: 325 GLQDAAEDPEAPEGSAQTPAAPL-DGANVSCS------------PRPGAPPAAI-GARVF 370 Query: 380 GLATLLILTVTAIVAKILL 398 TVTA+ +LL Sbjct: 371 S-------TVTAVSVLLLL 382 >gi|13375642 kringle-containing transmembrane protein 2 isoform b precursor [Homo sapiens] Length = 420 Score = 327 bits (839), Expect = 1e-89 Identities = 161/332 (48%), Positives = 219/332 (65%), Gaps = 11/332 (3%) Query: 25 SPGLGPGPECFTANGADYRGTQNWTALQG-GKPCLFWNETFQHPYNTLKYPNGEGGLGEH 83 SPGL ECF NGADYRG QN T +G G+PCLFW++T QH Y++ P+G GLG H Sbjct: 30 SPGLS---ECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAH 86 Query: 84 NYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPACQMPGNLGCYKDHGNPPPLTGTSKTSNK 143 N+CRNPDGDV PWCYVAE E+G+YW+YC+IP+C MPG LGC+ D G PP L+G S TS K Sbjct: 87 NFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSCHMPGYLGCFVDSGAPPALSGPSGTSTK 146 Query: 144 LTIQTCISFCRSQRFKFAGMESGYACFCGNNPDYWKYGEAASTECNSVCFGDHTQPCGGD 203 LT+Q C+ FCR + ++ AG+E+GYACFCG+ D + A +T+C+ +CFG Q CGGD Sbjct: 147 LTVQVCLRFCRMKGYQLAGVEAGYACFCGSESDLARGRLAPATDCDQICFGHPGQLCGGD 206 Query: 204 GRIILFDTLVGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDI 263 GR+ +++ VG+C GN++A V+YSPDFPD Y R C W + PGA+ + +F LF++ Sbjct: 207 GRLGVYEVSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALGPPGAA-LELTFRLFEL 265 Query: 264 RDSADMVELLDGYTHRVLARFHGRSRPPLS--FNVSLDFVILYFFSDRINQAQGFAVLYQ 321 D D +EL D + +L F G +RPP S + ++L F SD AQGFA+ Y+ Sbjct: 266 ADPRDRLELRDAASGSLLRAFDG-ARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYR 324 Query: 322 AVKE--ELPQERPAVNQTVAEVITEQANLSVS 351 +++ E P+ QT A + + AN+S S Sbjct: 325 GLQDAAEDPEAPEGSAQTPAAPL-DGANVSCS 355 >gi|4758502 hyaluronan binding protein 2 preproprotein [Homo sapiens] Length = 560 Score = 84.0 bits (206), Expect = 3e-16 Identities = 36/86 (41%), Positives = 47/86 (54%), Gaps = 4/86 (4%) Query: 33 ECFTANGADYRGTQNWTALQGGKPCLFWNE--TFQHPYNTLKYPNGEGGLGEHNYCRNPD 90 +C+ +G YRG N T Q CL+WN Q YN G+GEHN+CRNPD Sbjct: 193 DCYVGDGYSYRGKMNRTVNQHA--CLYWNSHLLLQENYNMFMEDAETHGIGEHNFCRNPD 250 Query: 91 GDVSPWCYVAEHEDGVYWKYCEIPAC 116 D PWC++ D V W+YC++ AC Sbjct: 251 ADEKPWCFIKVTNDKVKWEYCDVSAC 276 >gi|4505861 plasminogen activator, tissue isoform 1 preproprotein [Homo sapiens] Length = 562 Score = 83.6 bits (205), Expect = 3e-16 Identities = 42/101 (41%), Positives = 59/101 (58%), Gaps = 8/101 (7%) Query: 22 PAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFWNETFQ-HPYNTLKYPNGEG-G 79 PA S G +C+ NG+ YRGT + T + G CL WN T + P+ + G Sbjct: 206 PACSEG---NSDCYFGNGSAYRGTHSLT--ESGASCLPWNSMILIGKVYTAQNPSAQALG 260 Query: 80 LGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPACQMPG 120 LG+HNYCRNPDGD PWC+V ++ + W+YC++P+C G Sbjct: 261 LGKHNYCRNPDGDAKPWCHVLKNR-RLTWEYCDVPSCSTCG 300 Score = 78.2 bits (191), Expect = 1e-14 Identities = 42/100 (42%), Positives = 53/100 (53%), Gaps = 8/100 (8%) Query: 34 CFTANGADYRGTQNWTALQGGKPCLFWNETF--QHPYNTLKYPNGEGGLGEHNYCRNPDG 91 C+ G YRGT W+ + G C WN + Q PY+ + GLG HNYCRNPD Sbjct: 127 CYEDQGISYRGT--WSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDR 184 Query: 92 DVSPWCYVAEHEDGVY-WKYCEIPACQMPGNLGCYKDHGN 130 D PWCYV + G Y ++C PAC GN CY +G+ Sbjct: 185 DSKPWCYV--FKAGKYSSEFCSTPACS-EGNSDCYFGNGS 221 >gi|14702169 plasminogen activator, tissue isoform 3 preproprotein [Homo sapiens] Length = 516 Score = 83.6 bits (205), Expect = 3e-16 Identities = 42/101 (41%), Positives = 59/101 (58%), Gaps = 8/101 (7%) Query: 22 PAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFWNETFQ-HPYNTLKYPNGEG-G 79 PA S G +C+ NG+ YRGT + T + G CL WN T + P+ + G Sbjct: 160 PACSEG---NSDCYFGNGSAYRGTHSLT--ESGASCLPWNSMILIGKVYTAQNPSAQALG 214 Query: 80 LGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPACQMPG 120 LG+HNYCRNPDGD PWC+V ++ + W+YC++P+C G Sbjct: 215 LGKHNYCRNPDGDAKPWCHVLKNR-RLTWEYCDVPSCSTCG 254 Score = 78.2 bits (191), Expect = 1e-14 Identities = 42/100 (42%), Positives = 53/100 (53%), Gaps = 8/100 (8%) Query: 34 CFTANGADYRGTQNWTALQGGKPCLFWNETF--QHPYNTLKYPNGEGGLGEHNYCRNPDG 91 C+ G YRGT W+ + G C WN + Q PY+ + GLG HNYCRNPD Sbjct: 81 CYEDQGISYRGT--WSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDR 138 Query: 92 DVSPWCYVAEHEDGVY-WKYCEIPACQMPGNLGCYKDHGN 130 D PWCYV + G Y ++C PAC GN CY +G+ Sbjct: 139 DSKPWCYV--FKAGKYSSEFCSTPACS-EGNSDCYFGNGS 175 >gi|4504383 HGF activator preproprotein [Homo sapiens] Length = 655 Score = 75.5 bits (184), Expect = 9e-14 Identities = 41/114 (35%), Positives = 54/114 (47%), Gaps = 9/114 (7%) Query: 10 LLSAAALTLAARPAPSPG----LGPGPECFTANGADYRGTQNWTALQGGKPCLFWNETFQ 65 L+ A T+ A P G + P CF NG YRG + +A G CL WN Sbjct: 258 LIVATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVASTSA--SGLSCLAWNSDLL 315 Query: 66 HPYNTLKYPNGEG--GLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPACQ 117 + + GLG H YCRNPD D PWCYV + + + W+YC + AC+ Sbjct: 316 YQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYVVK-DSALSWEYCRLEACE 368 >gi|4505881 plasminogen [Homo sapiens] Length = 810 Score = 70.1 bits (170), Expect = 4e-12 Identities = 44/135 (32%), Positives = 56/135 (41%), Gaps = 24/135 (17%) Query: 24 PSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEH 83 P P GP +C G +YRG N G C W+ H +N L E Sbjct: 265 PPPSSGPTYQCLKGTGENYRG--NVAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNLDE- 321 Query: 84 NYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPACQ-----------------MPGNLGCYK 126 NYCRNPDG +PWC+ + V W+YC+IP+C P CY Sbjct: 322 NYCRNPDGKRAPWCHTTNSQ--VRWEYCKIPSCDSSPVSTEQLAPTAPPELTPVVQDCY- 378 Query: 127 DHGNPPPLTGTSKTS 141 HG+ GTS T+ Sbjct: 379 -HGDGQSYRGTSSTT 392 Score = 66.2 bits (160), Expect = 6e-11 Identities = 39/108 (36%), Positives = 50/108 (46%), Gaps = 10/108 (9%) Query: 12 SAAALTLAARPAPSPGLGPG-PECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNT 70 S+ T P P L P +C+ +G YRGT + T GK C W+ H + Sbjct: 354 SSPVSTEQLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTTT--GKKCQSWSSMTPHRHQK 411 Query: 71 L--KYPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPAC 116 YPN GL NYCRNPD D PWC+ + V W+YC + C Sbjct: 412 TPENYPNA--GL-TMNYCRNPDADKGPWCFTT--DPSVRWEYCNLKKC 454 Score = 63.9 bits (154), Expect = 3e-10 Identities = 39/106 (36%), Positives = 47/106 (44%), Gaps = 8/106 (7%) Query: 33 ECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTLK-YPNGEGGLGEHNYCRNPDG 91 +C NG YRG + T G PC W H ++ N GL E NYCRNPDG Sbjct: 480 DCMFGNGKGYRGKRATTVT--GTPCQDWAAQEPHRHSIFTPETNPRAGL-EKNYCRNPDG 536 Query: 92 DV-SPWCYVAEHEDGVYWKYCEIPACQMPGNLGCYKDHGNPPPLTG 136 DV PWCY + YC++P C P + C K P G Sbjct: 537 DVGGPWCYTTNPRK--LYDYCDVPQCAAP-SFDCGKPQVEPKKCPG 579 Score = 61.6 bits (148), Expect = 1e-09 Identities = 35/86 (40%), Positives = 44/86 (51%), Gaps = 6/86 (6%) Query: 33 ECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPDGD 92 EC T NG +YRGT + T + G C W+ T H + GL E NYCRNPD D Sbjct: 102 ECKTGNGKNYRGTMSKT--KNGITCQKWSSTSPHRPRFSPATHPSEGL-EENYCRNPDND 158 Query: 93 -VSPWCYVAEHEDGVYWKYCEIPACQ 117 PWCY + E + YC+I C+ Sbjct: 159 PQGPWCYTTDPEK--RYDYCDILECE 182 Score = 56.6 bits (135), Expect = 5e-08 Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 9/89 (10%) Query: 33 ECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTL--KYPNGEGGLGEHNYCRNPD 90 EC +G +Y G + T G C W+ H + + K+PN + NYCRNPD Sbjct: 184 ECMHCSGENYDGKISKT--MSGLECQAWDSQSPHAHGYIPSKFPNKNL---KKNYCRNPD 238 Query: 91 GDVSPWCYVAEHEDGVYWKYCEIPACQMP 119 ++ PWC+ + W+ C+IP C P Sbjct: 239 RELRPWCFTT--DPNKRWELCDIPRCTTP 265 >gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens] Length = 3667 Score = 68.9 bits (167), Expect = 9e-12 Identities = 43/123 (34%), Positives = 57/123 (46%), Gaps = 4/123 (3%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDG 275 CGG S S V+ SP FP Y + C WTI +P +H F F D +E+ G Sbjct: 2071 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSG 2130 Query: 276 --YTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVK-EELPQERP 332 T V+ R G P F+ + + LYF SD QGF ++YQA + + P RP Sbjct: 2131 SSETSTVIGRLSGPQIPSSLFSTTHE-TSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRP 2189 Query: 333 AVN 335 N Sbjct: 2190 FRN 2192 Score = 65.5 bits (158), Expect = 1e-10 Identities = 49/172 (28%), Positives = 80/172 (46%), Gaps = 22/172 (12%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDG 275 CGGN +AM+ +YSP +PD Y + C+W +RVP + I+ +F + D + + DG Sbjct: 2243 CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDG 2302 Query: 276 --YTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVL-YQAVKEELPQERP 332 + +F G + ++ S + +++ F SD GF VL Y A + + Q P Sbjct: 2303 PDQNSPQIGQFSGNTALESVYSTS-NQILIKFHSD--FTTSGFFVLSYHAYQLRVCQPPP 2359 Query: 333 AVNQTVAEVITEQANLSVSAARSSKVLYVITTSPSHPPQTVPGWTVYGLATL 384 V AE++TE + + Y Q +PG+T+ G A L Sbjct: 2360 PVPN--AEILTEDDEFEI----GDIIRY----------QCLPGFTLVGNAIL 2395 Score = 58.9 bits (141), Expect = 9e-09 Identities = 37/126 (29%), Positives = 59/126 (46%), Gaps = 6/126 (4%) Query: 203 DGRII---LFDTLVGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFP 259 DG+++ L CGG++SA S V+ SP +P Y C W I I +F Sbjct: 839 DGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFE 898 Query: 260 LFDIRDSADMVELLDG--YTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFA 317 F + D++E+ DG +L ++G P F+ S +F+ L F +D GF Sbjct: 899 RFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFS-SSNFIYLLFTTDNSRSNNGFK 957 Query: 318 VLYQAV 323 + Y++V Sbjct: 958 IHYESV 963 Score = 54.3 bits (129), Expect = 2e-07 Identities = 33/107 (30%), Positives = 48/107 (44%), Gaps = 3/107 (2%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDG 275 C N++A V SPD+P+ Y C WTI S IH SF FD+ D + + DG Sbjct: 681 CLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDG 740 Query: 276 YTHR--VLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLY 320 + +L F G + P + + L F +D +GF + Y Sbjct: 741 DSPESPILGTFTG-AEVPSHLTSNSHILRLEFQADHSMSGRGFNITY 786 Score = 52.0 bits (123), Expect = 1e-06 Identities = 38/125 (30%), Positives = 56/125 (44%), Gaps = 6/125 (4%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLD- 274 CGG+ S + SP +P+ Y C WT+ V + F+F F + D D + + + Sbjct: 1027 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITEN 1086 Query: 275 GYTHRVLARFHGRSRPPLSFNVSL--DF-VILYFFSDRINQAQGFAVLYQAVKEELPQER 331 G + LAR G PP + N L +F L F SD +GF + + E P E Sbjct: 1087 GSFTQPLARLTGSDLPP-TINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLE-PCED 1144 Query: 332 PAVNQ 336 P + Q Sbjct: 1145 PGIPQ 1149 Score = 50.8 bits (120), Expect = 2e-06 Identities = 34/114 (29%), Positives = 48/114 (42%), Gaps = 9/114 (7%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDG 275 CGG ++ + SP FP Y G C W I + I F F + + D + L DG Sbjct: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 84 Query: 276 YTHRV-----LARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVK 324 + H L FH PP++ S+ L SD A GF V Y+ ++ Sbjct: 85 HPHPTNFRTRLTGFH--LPPPVTSTKSV--FSLRLTSDFAVSAHGFKVYYEELQ 134 Score = 50.8 bits (120), Expect = 2e-06 Identities = 36/115 (31%), Positives = 51/115 (44%), Gaps = 1/115 (0%) Query: 213 VGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVEL 272 + CGGN + S + SP+FP Y R C WTI V I +F F I + D + + Sbjct: 1545 IAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYI 1604 Query: 273 LDG-YTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVKEE 326 DG ++ L S+ P S + + L F SD GF + Y+A E Sbjct: 1605 YDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRE 1659 Score = 48.1 bits (113), Expect = 2e-05 Identities = 48/194 (24%), Positives = 86/194 (44%), Gaps = 23/194 (11%) Query: 200 CGGDGRIILFDTL---VGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHF 256 C G GR + L V CG + + ++ SP++P Y C ++I+V I+ Sbjct: 1182 CLGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINI 1241 Query: 257 SFPLFDIRDSADMVELLDG--YTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQ 314 S F + D++++ DG T +L F G S L+ + + + + L F SD + Sbjct: 1242 SARTFHLA-QGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDE 1300 Query: 315 GFAVLYQAVKEELPQERPAVNQTVAEVITEQANLSVSAARSSKVLYVITTSPSHPPQTVP 374 GF ++Y + E E P + Q I++Q + + S ++Y P Sbjct: 1301 GFQLVYTSF-ELSHCEDPGIPQ-FGYKISDQGHFA-----GSTIIYGCN----------P 1343 Query: 375 GWTVYGLATLLILT 388 G+T++G + L +T Sbjct: 1344 GYTLHGSSLLKCMT 1357 Score = 47.4 bits (111), Expect = 3e-05 Identities = 30/107 (28%), Positives = 49/107 (45%), Gaps = 3/107 (2%) Query: 215 ACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLD 274 ACGG S ++ SP FP+ Y C WTI I F F + + D +E ++ Sbjct: 200 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLE-IE 258 Query: 275 GYTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQ 321 G + PP+ N +++ L+F +D ++ +GF+ YQ Sbjct: 259 GSEPPTIWLSGMNIPPPIISN--KNWLRLHFVTDSNHRYRGFSAPYQ 303 Score = 47.0 bits (110), Expect = 4e-05 Identities = 41/155 (26%), Positives = 62/155 (40%), Gaps = 17/155 (10%) Query: 174 NPDYWKYGEAA---STECNSVCFGDHTQPCGGDGRIILFDTLVGACGGNYSAMSSVVYSP 230 NP Y +G A T NS+ + + P T + CGG + + SP Sbjct: 1865 NPGYILHGSIAIRCETVPNSLAQWNDSLP-----------TCIVPCGGILTKRKGTILSP 1913 Query: 231 DFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDGYTHRV--LARFHGRS 288 +P+ Y C W I VP + I F + D ++ DG + L + G + Sbjct: 1914 GYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTT 1973 Query: 289 RPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAV 323 P L N + + + L F SD A GF + Y A+ Sbjct: 1974 IPHL-LNSTSNNLYLNFQSDISVSAAGFHLEYTAI 2007 Score = 46.2 bits (108), Expect = 6e-05 Identities = 47/158 (29%), Positives = 67/158 (42%), Gaps = 16/158 (10%) Query: 178 WKYGEAASTECNS--VCFGDHTQPC--GGDGRIILFDTLVGA---CGGNYSAMSSVVYSP 230 +K G + C++ V G T C G DGR L CG + V SP Sbjct: 1677 YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSEGTVLSP 1736 Query: 231 DFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDGYTHR-----VLARFH 285 ++P Y+ G C ++I VP + F F D+VE+ DG T + L+ H Sbjct: 1737 NYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQ-TSLHDVVEVYDGPTQQSSLLSSLSGSH 1795 Query: 286 GRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAV 323 PLS S + + + F S A+GF +YQAV Sbjct: 1796 SGESLPLS---SGNQITIRFTSVGPITAKGFHFVYQAV 1830 Score = 45.8 bits (107), Expect = 8e-05 Identities = 30/112 (26%), Positives = 49/112 (43%), Gaps = 2/112 (1%) Query: 213 VGACGGNYSAMSSV-VYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVE 271 + CGG + SS + SP +P Y C W I V + + F FD S D++ Sbjct: 1371 IAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILR 1430 Query: 272 LLDGYTHR-VLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQA 322 + DG +L + S P + +L+ V + F +D GFA+ + + Sbjct: 1431 VWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSS 1482 Score = 43.5 bits (101), Expect = 4e-04 Identities = 28/111 (25%), Positives = 47/111 (42%), Gaps = 2/111 (1%) Query: 224 SSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDG--YTHRVL 281 + V+ SP +PD+Y ++C W+I V +I F D++++ DG VL Sbjct: 2426 TGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYDGPNIQSPVL 2485 Query: 282 ARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVKEELPQERP 332 G + + V L + +D N +GF + Y A P+ P Sbjct: 2486 ISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESPP 2536 Score = 40.8 bits (94), Expect = 0.003 Identities = 33/119 (27%), Positives = 50/119 (42%), Gaps = 6/119 (5%) Query: 213 VGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASH-IHFSFPLFDIRDSADMVE 271 V CG N S SP+FP Y + C W I + I +F FD+ D + Sbjct: 505 VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 564 Query: 272 LLD----GYTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVKEE 326 + D G VL G P L ++S + L+ +D + GF V Y+ +++E Sbjct: 565 IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQ-MWLHLQTDESVGSVGFKVNYKEIEKE 622 >gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sapiens] Length = 3538 Score = 68.9 bits (167), Expect = 9e-12 Identities = 43/123 (34%), Positives = 57/123 (46%), Gaps = 4/123 (3%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDG 275 CGG S S V+ SP FP Y + C WTI +P +H F F D +E+ G Sbjct: 2007 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSG 2066 Query: 276 --YTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVK-EELPQERP 332 T V+ R G P F+ + + LYF SD QGF ++YQA + + P RP Sbjct: 2067 SSETSTVIGRLSGPQIPSSLFSTTHE-TSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRP 2125 Query: 333 AVN 335 N Sbjct: 2126 FRN 2128 Score = 65.5 bits (158), Expect = 1e-10 Identities = 49/172 (28%), Positives = 80/172 (46%), Gaps = 22/172 (12%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDG 275 CGGN +AM+ +YSP +PD Y + C+W +RVP + I+ +F + D + + DG Sbjct: 2179 CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDG 2238 Query: 276 --YTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVL-YQAVKEELPQERP 332 + +F G + ++ S + +++ F SD GF VL Y A + + Q P Sbjct: 2239 PDQNSPQIGQFSGNTALESVYSTS-NQILIKFHSD--FTTSGFFVLSYHAYQLRVCQPPP 2295 Query: 333 AVNQTVAEVITEQANLSVSAARSSKVLYVITTSPSHPPQTVPGWTVYGLATL 384 V AE++TE + + Y Q +PG+T+ G A L Sbjct: 2296 PVPN--AEILTEDDEFEI----GDIIRY----------QCLPGFTLVGNAIL 2331 Score = 58.9 bits (141), Expect = 9e-09 Identities = 37/126 (29%), Positives = 59/126 (46%), Gaps = 6/126 (4%) Query: 203 DGRII---LFDTLVGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFP 259 DG+++ L CGG++SA S V+ SP +P Y C W I I +F Sbjct: 775 DGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFE 834 Query: 260 LFDIRDSADMVELLDG--YTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFA 317 F + D++E+ DG +L ++G P F+ S +F+ L F +D GF Sbjct: 835 RFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFS-SSNFIYLLFTTDNSRSNNGFK 893 Query: 318 VLYQAV 323 + Y++V Sbjct: 894 IHYESV 899 Score = 54.3 bits (129), Expect = 2e-07 Identities = 33/107 (30%), Positives = 48/107 (44%), Gaps = 3/107 (2%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDG 275 C N++A V SPD+P+ Y C WTI S IH SF FD+ D + + DG Sbjct: 617 CLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDG 676 Query: 276 YTHR--VLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLY 320 + +L F G + P + + L F +D +GF + Y Sbjct: 677 DSPESPILGTFTG-AEVPSHLTSNSHILRLEFQADHSMSGRGFNITY 722 Score = 52.0 bits (123), Expect = 1e-06 Identities = 38/125 (30%), Positives = 56/125 (44%), Gaps = 6/125 (4%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLD- 274 CGG+ S + SP +P+ Y C WT+ V + F+F F + D D + + + Sbjct: 963 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITEN 1022 Query: 275 GYTHRVLARFHGRSRPPLSFNVSL--DF-VILYFFSDRINQAQGFAVLYQAVKEELPQER 331 G + LAR G PP + N L +F L F SD +GF + + E P E Sbjct: 1023 GSFTQPLARLTGSDLPP-TINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLE-PCED 1080 Query: 332 PAVNQ 336 P + Q Sbjct: 1081 PGIPQ 1085 Score = 50.8 bits (120), Expect = 2e-06 Identities = 34/114 (29%), Positives = 48/114 (42%), Gaps = 9/114 (7%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDG 275 CGG ++ + SP FP Y G C W I + I F F + + D + L DG Sbjct: 65 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 124 Query: 276 YTHRV-----LARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVK 324 + H L FH PP++ S+ L SD A GF V Y+ ++ Sbjct: 125 HPHPTNFRTRLTGFH--LPPPVTSTKSV--FSLRLTSDFAVSAHGFKVYYEELQ 174 Score = 50.8 bits (120), Expect = 2e-06 Identities = 36/115 (31%), Positives = 51/115 (44%), Gaps = 1/115 (0%) Query: 213 VGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVEL 272 + CGGN + S + SP+FP Y R C WTI V I +F F I + D + + Sbjct: 1481 IAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYI 1540 Query: 273 LDG-YTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVKEE 326 DG ++ L S+ P S + + L F SD GF + Y+A E Sbjct: 1541 YDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRE 1595 Score = 48.5 bits (114), Expect = 1e-05 Identities = 31/110 (28%), Positives = 50/110 (45%), Gaps = 3/110 (2%) Query: 215 ACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLD 274 ACGG S ++ SP FP+ Y C WTI I F F + + D +E ++ Sbjct: 240 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLE-IE 298 Query: 275 GYTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVK 324 G + PP+ N +++ L+F +D ++ +GF+ YQ K Sbjct: 299 GSEPPTIWLSGMNIPPPIISN--KNWLRLHFVTDSNHRYRGFSAPYQVKK 346 Score = 48.1 bits (113), Expect = 2e-05 Identities = 48/194 (24%), Positives = 86/194 (44%), Gaps = 23/194 (11%) Query: 200 CGGDGRIILFDTL---VGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHF 256 C G GR + L V CG + + ++ SP++P Y C ++I+V I+ Sbjct: 1118 CLGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINI 1177 Query: 257 SFPLFDIRDSADMVELLDG--YTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQ 314 S F + D++++ DG T +L F G S L+ + + + + L F SD + Sbjct: 1178 SARTFHLA-QGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDE 1236 Query: 315 GFAVLYQAVKEELPQERPAVNQTVAEVITEQANLSVSAARSSKVLYVITTSPSHPPQTVP 374 GF ++Y + E E P + Q I++Q + + S ++Y P Sbjct: 1237 GFQLVYTSF-ELSHCEDPGIPQ-FGYKISDQGHFA-----GSTIIYGCN----------P 1279 Query: 375 GWTVYGLATLLILT 388 G+T++G + L +T Sbjct: 1280 GYTLHGSSLLKCMT 1293 Score = 47.0 bits (110), Expect = 4e-05 Identities = 41/155 (26%), Positives = 62/155 (40%), Gaps = 17/155 (10%) Query: 174 NPDYWKYGEAA---STECNSVCFGDHTQPCGGDGRIILFDTLVGACGGNYSAMSSVVYSP 230 NP Y +G A T NS+ + + P T + CGG + + SP Sbjct: 1801 NPGYILHGSIAIRCETVPNSLAQWNDSLP-----------TCIVPCGGILTKRKGTILSP 1849 Query: 231 DFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDGYTHRV--LARFHGRS 288 +P+ Y C W I VP + I F + D ++ DG + L + G + Sbjct: 1850 GYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTT 1909 Query: 289 RPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAV 323 P L N + + + L F SD A GF + Y A+ Sbjct: 1910 IPHL-LNSTSNNLYLNFQSDISVSAAGFHLEYTAI 1943 Score = 46.2 bits (108), Expect = 6e-05 Identities = 47/158 (29%), Positives = 67/158 (42%), Gaps = 16/158 (10%) Query: 178 WKYGEAASTECNS--VCFGDHTQPC--GGDGRIILFDTLVGA---CGGNYSAMSSVVYSP 230 +K G + C++ V G T C G DGR L CG + V SP Sbjct: 1613 YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSEGTVLSP 1672 Query: 231 DFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDGYTHR-----VLARFH 285 ++P Y+ G C ++I VP + F F D+VE+ DG T + L+ H Sbjct: 1673 NYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQ-TSLHDVVEVYDGPTQQSSLLSSLSGSH 1731 Query: 286 GRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAV 323 PLS S + + + F S A+GF +YQAV Sbjct: 1732 SGESLPLS---SGNQITIRFTSVGPITAKGFHFVYQAV 1766 Score = 45.8 bits (107), Expect = 8e-05 Identities = 30/112 (26%), Positives = 49/112 (43%), Gaps = 2/112 (1%) Query: 213 VGACGGNYSAMSSV-VYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVE 271 + CGG + SS + SP +P Y C W I V + + F FD S D++ Sbjct: 1307 IAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILR 1366 Query: 272 LLDGYTHR-VLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQA 322 + DG +L + S P + +L+ V + F +D GFA+ + + Sbjct: 1367 VWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSS 1418 Score = 43.5 bits (101), Expect = 4e-04 Identities = 28/111 (25%), Positives = 47/111 (42%), Gaps = 2/111 (1%) Query: 224 SSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDG--YTHRVL 281 + V+ SP +PD+Y ++C W+I V +I F D++++ DG VL Sbjct: 2362 TGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYDGPNIQSPVL 2421 Query: 282 ARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVKEELPQERP 332 G + + V L + +D N +GF + Y A P+ P Sbjct: 2422 ISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESPP 2472 Score = 40.8 bits (94), Expect = 0.003 Identities = 33/119 (27%), Positives = 50/119 (42%), Gaps = 6/119 (5%) Query: 213 VGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASH-IHFSFPLFDIRDSADMVE 271 V CG N S SP+FP Y + C W I + I +F FD+ D + Sbjct: 441 VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 500 Query: 272 LLD----GYTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVKEE 326 + D G VL G P L ++S + L+ +D + GF V Y+ +++E Sbjct: 501 IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQ-MWLHLQTDESVGSVGFKVNYKEIEKE 558 >gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens] Length = 3707 Score = 68.9 bits (167), Expect = 9e-12 Identities = 43/123 (34%), Positives = 57/123 (46%), Gaps = 4/123 (3%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDG 275 CGG S S V+ SP FP Y + C WTI +P +H F F D +E+ G Sbjct: 2111 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSG 2170 Query: 276 --YTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVK-EELPQERP 332 T V+ R G P F+ + + LYF SD QGF ++YQA + + P RP Sbjct: 2171 SSETSTVIGRLSGPQIPSSLFSTTHE-TSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRP 2229 Query: 333 AVN 335 N Sbjct: 2230 FRN 2232 Score = 65.5 bits (158), Expect = 1e-10 Identities = 49/172 (28%), Positives = 80/172 (46%), Gaps = 22/172 (12%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDG 275 CGGN +AM+ +YSP +PD Y + C+W +RVP + I+ +F + D + + DG Sbjct: 2283 CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDG 2342 Query: 276 --YTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVL-YQAVKEELPQERP 332 + +F G + ++ S + +++ F SD GF VL Y A + + Q P Sbjct: 2343 PDQNSPQIGQFSGNTALESVYSTS-NQILIKFHSD--FTTSGFFVLSYHAYQLRVCQPPP 2399 Query: 333 AVNQTVAEVITEQANLSVSAARSSKVLYVITTSPSHPPQTVPGWTVYGLATL 384 V AE++TE + + Y Q +PG+T+ G A L Sbjct: 2400 PVPN--AEILTEDDEFEI----GDIIRY----------QCLPGFTLVGNAIL 2435 Score = 58.9 bits (141), Expect = 9e-09 Identities = 37/126 (29%), Positives = 59/126 (46%), Gaps = 6/126 (4%) Query: 203 DGRII---LFDTLVGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFP 259 DG+++ L CGG++SA S V+ SP +P Y C W I I +F Sbjct: 879 DGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFE 938 Query: 260 LFDIRDSADMVELLDG--YTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFA 317 F + D++E+ DG +L ++G P F+ S +F+ L F +D GF Sbjct: 939 RFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFS-SSNFIYLLFTTDNSRSNNGFK 997 Query: 318 VLYQAV 323 + Y++V Sbjct: 998 IHYESV 1003 Score = 54.3 bits (129), Expect = 2e-07 Identities = 33/107 (30%), Positives = 48/107 (44%), Gaps = 3/107 (2%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDG 275 C N++A V SPD+P+ Y C WTI S IH SF FD+ D + + DG Sbjct: 721 CLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDG 780 Query: 276 YTHR--VLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLY 320 + +L F G + P + + L F +D +GF + Y Sbjct: 781 DSPESPILGTFTG-AEVPSHLTSNSHILRLEFQADHSMSGRGFNITY 826 Score = 52.0 bits (123), Expect = 1e-06 Identities = 38/125 (30%), Positives = 56/125 (44%), Gaps = 6/125 (4%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLD- 274 CGG+ S + SP +P+ Y C WT+ V + F+F F + D D + + + Sbjct: 1067 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITEN 1126 Query: 275 GYTHRVLARFHGRSRPPLSFNVSL--DF-VILYFFSDRINQAQGFAVLYQAVKEELPQER 331 G + LAR G PP + N L +F L F SD +GF + + E P E Sbjct: 1127 GSFTQPLARLTGSDLPP-TINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLE-PCED 1184 Query: 332 PAVNQ 336 P + Q Sbjct: 1185 PGIPQ 1189 Score = 50.8 bits (120), Expect = 2e-06 Identities = 34/114 (29%), Positives = 48/114 (42%), Gaps = 9/114 (7%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDG 275 CGG ++ + SP FP Y G C W I + I F F + + D + L DG Sbjct: 65 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 124 Query: 276 YTHRV-----LARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVK 324 + H L FH PP++ S+ L SD A GF V Y+ ++ Sbjct: 125 HPHPTNFRTRLTGFH--LPPPVTSTKSV--FSLRLTSDFAVSAHGFKVYYEELQ 174 Score = 50.8 bits (120), Expect = 2e-06 Identities = 36/115 (31%), Positives = 51/115 (44%), Gaps = 1/115 (0%) Query: 213 VGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVEL 272 + CGGN + S + SP+FP Y R C WTI V I +F F I + D + + Sbjct: 1585 IAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYI 1644 Query: 273 LDG-YTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVKEE 326 DG ++ L S+ P S + + L F SD GF + Y+A E Sbjct: 1645 YDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRE 1699 Score = 48.1 bits (113), Expect = 2e-05 Identities = 48/194 (24%), Positives = 86/194 (44%), Gaps = 23/194 (11%) Query: 200 CGGDGRIILFDTL---VGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHF 256 C G GR + L V CG + + ++ SP++P Y C ++I+V I+ Sbjct: 1222 CLGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINI 1281 Query: 257 SFPLFDIRDSADMVELLDG--YTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQ 314 S F + D++++ DG T +L F G S L+ + + + + L F SD + Sbjct: 1282 SARTFHLA-QGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDE 1340 Query: 315 GFAVLYQAVKEELPQERPAVNQTVAEVITEQANLSVSAARSSKVLYVITTSPSHPPQTVP 374 GF ++Y + E E P + Q I++Q + + S ++Y P Sbjct: 1341 GFQLVYTSF-ELSHCEDPGIPQ-FGYKISDQGHFA-----GSTIIYGCN----------P 1383 Query: 375 GWTVYGLATLLILT 388 G+T++G + L +T Sbjct: 1384 GYTLHGSSLLKCMT 1397 Score = 47.4 bits (111), Expect = 3e-05 Identities = 30/107 (28%), Positives = 49/107 (45%), Gaps = 3/107 (2%) Query: 215 ACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLD 274 ACGG S ++ SP FP+ Y C WTI I F F + + D +E ++ Sbjct: 240 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLE-IE 298 Query: 275 GYTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQ 321 G + PP+ N +++ L+F +D ++ +GF+ YQ Sbjct: 299 GSEPPTIWLSGMNIPPPIISN--KNWLRLHFVTDSNHRYRGFSAPYQ 343 Score = 47.0 bits (110), Expect = 4e-05 Identities = 41/155 (26%), Positives = 62/155 (40%), Gaps = 17/155 (10%) Query: 174 NPDYWKYGEAA---STECNSVCFGDHTQPCGGDGRIILFDTLVGACGGNYSAMSSVVYSP 230 NP Y +G A T NS+ + + P T + CGG + + SP Sbjct: 1905 NPGYILHGSIAIRCETVPNSLAQWNDSLP-----------TCIVPCGGILTKRKGTILSP 1953 Query: 231 DFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDGYTHRV--LARFHGRS 288 +P+ Y C W I VP + I F + D ++ DG + L + G + Sbjct: 1954 GYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTT 2013 Query: 289 RPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAV 323 P L N + + + L F SD A GF + Y A+ Sbjct: 2014 IPHL-LNSTSNNLYLNFQSDISVSAAGFHLEYTAI 2047 Score = 46.2 bits (108), Expect = 6e-05 Identities = 47/158 (29%), Positives = 67/158 (42%), Gaps = 16/158 (10%) Query: 178 WKYGEAASTECNS--VCFGDHTQPC--GGDGRIILFDTLVGA---CGGNYSAMSSVVYSP 230 +K G + C++ V G T C G DGR L CG + V SP Sbjct: 1717 YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSEGTVLSP 1776 Query: 231 DFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDGYTHR-----VLARFH 285 ++P Y+ G C ++I VP + F F D+VE+ DG T + L+ H Sbjct: 1777 NYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQ-TSLHDVVEVYDGPTQQSSLLSSLSGSH 1835 Query: 286 GRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAV 323 PLS S + + + F S A+GF +YQAV Sbjct: 1836 SGESLPLS---SGNQITIRFTSVGPITAKGFHFVYQAV 1870 Score = 45.8 bits (107), Expect = 8e-05 Identities = 30/112 (26%), Positives = 49/112 (43%), Gaps = 2/112 (1%) Query: 213 VGACGGNYSAMSSV-VYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVE 271 + CGG + SS + SP +P Y C W I V + + F FD S D++ Sbjct: 1411 IAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILR 1470 Query: 272 LLDGYTHR-VLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQA 322 + DG +L + S P + +L+ V + F +D GFA+ + + Sbjct: 1471 VWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSS 1522 Score = 43.5 bits (101), Expect = 4e-04 Identities = 28/111 (25%), Positives = 47/111 (42%), Gaps = 2/111 (1%) Query: 224 SSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDG--YTHRVL 281 + V+ SP +PD+Y ++C W+I V +I F D++++ DG VL Sbjct: 2466 TGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYDGPNIQSPVL 2525 Query: 282 ARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVKEELPQERP 332 G + + V L + +D N +GF + Y A P+ P Sbjct: 2526 ISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESPP 2576 Score = 40.8 bits (94), Expect = 0.003 Identities = 33/119 (27%), Positives = 50/119 (42%), Gaps = 6/119 (5%) Query: 213 VGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASH-IHFSFPLFDIRDSADMVE 271 V CG N S SP+FP Y + C W I + I +F FD+ D + Sbjct: 545 VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 604 Query: 272 LLD----GYTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVKEE 326 + D G VL G P L ++S + L+ +D + GF V Y+ +++E Sbjct: 605 IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQ-MWLHLQTDESVGSVGFKVNYKEIEKE 662 >gi|116292750 lipoprotein Lp(a) precursor [Homo sapiens] Length = 2040 Score = 68.6 bits (166), Expect = 1e-11 Identities = 40/107 (37%), Positives = 55/107 (51%), Gaps = 12/107 (11%) Query: 12 SAAALTLAARPAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPY--N 69 S A + A SPG+ +C+ +G YRG+ + T G+ C W+ H + Sbjct: 1149 STEASSEEAPTEQSPGV---QDCYHGDGQSYRGSFSTTVT--GRTCQSWSSMTPHWHQRT 1203 Query: 70 TLKYPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPAC 116 T YPN GGL NYCRNPD ++SPWCY + V W+YC + C Sbjct: 1204 TEYYPN--GGL-TRNYCRNPDAEISPWCYTM--DPNVRWEYCNLTQC 1245 Score = 67.4 bits (163), Expect = 3e-11 Identities = 54/180 (30%), Positives = 73/180 (40%), Gaps = 46/180 (25%) Query: 1 MAPPAARLALLSAAALTLAARPAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFW 60 +APP + +L + AP+ EC+ NG YRGT + T G+ C W Sbjct: 113 VAPPT----VTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVT--GRTCQAW 166 Query: 61 NETFQHPYNTLK--YPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPAC-- 116 + H ++ YPN GL NYCRNPD +P+CY + GV W+YC + C Sbjct: 167 SSMTPHSHSRTPEYYPNA--GL-IMNYCRNPDAVAAPYCYT--RDPGVRWEYCNLTQCSD 221 Query: 117 ---------------------------QMPGNLGCYKDHGNPPPLTGTSKTSNKLTIQTC 149 Q PG CY HGN GT T+ +T +TC Sbjct: 222 AEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECY--HGNGQSYRGTYSTT--VTGRTC 277 Score = 67.4 bits (163), Expect = 3e-11 Identities = 54/180 (30%), Positives = 73/180 (40%), Gaps = 46/180 (25%) Query: 1 MAPPAARLALLSAAALTLAARPAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFW 60 +APP + +L + AP+ EC+ NG YRGT + T G+ C W Sbjct: 227 VAPPT----VTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVT--GRTCQAW 280 Query: 61 NETFQHPYNTLK--YPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPAC-- 116 + H ++ YPN GL NYCRNPD +P+CY + GV W+YC + C Sbjct: 281 SSMTPHSHSRTPEYYPNA--GL-IMNYCRNPDAVAAPYCYT--RDPGVRWEYCNLTQCSD 335 Query: 117 ---------------------------QMPGNLGCYKDHGNPPPLTGTSKTSNKLTIQTC 149 Q PG CY HGN GT T+ +T +TC Sbjct: 336 AEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECY--HGNGQSYRGTYSTT--VTGRTC 391 Score = 67.4 bits (163), Expect = 3e-11 Identities = 54/180 (30%), Positives = 73/180 (40%), Gaps = 46/180 (25%) Query: 1 MAPPAARLALLSAAALTLAARPAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFW 60 +APP + +L + AP+ EC+ NG YRGT + T G+ C W Sbjct: 341 VAPPT----VTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVT--GRTCQAW 394 Query: 61 NETFQHPYNTLK--YPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPAC-- 116 + H ++ YPN GL NYCRNPD +P+CY + GV W+YC + C Sbjct: 395 SSMTPHSHSRTPEYYPNA--GL-IMNYCRNPDAVAAPYCYT--RDPGVRWEYCNLTQCSD 449 Query: 117 ---------------------------QMPGNLGCYKDHGNPPPLTGTSKTSNKLTIQTC 149 Q PG CY HGN GT T+ +T +TC Sbjct: 450 AEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECY--HGNGQSYRGTYSTT--VTGRTC 505 Score = 67.4 bits (163), Expect = 3e-11 Identities = 54/180 (30%), Positives = 73/180 (40%), Gaps = 46/180 (25%) Query: 1 MAPPAARLALLSAAALTLAARPAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFW 60 +APP + +L + AP+ EC+ NG YRGT + T G+ C W Sbjct: 455 VAPPT----VTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVT--GRTCQAW 508 Query: 61 NETFQHPYNTLK--YPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPAC-- 116 + H ++ YPN GL NYCRNPD +P+CY + GV W+YC + C Sbjct: 509 SSMTPHSHSRTPEYYPNA--GL-IMNYCRNPDAVAAPYCYT--RDPGVRWEYCNLTQCSD 563 Query: 117 ---------------------------QMPGNLGCYKDHGNPPPLTGTSKTSNKLTIQTC 149 Q PG CY HGN GT T+ +T +TC Sbjct: 564 AEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECY--HGNGQSYRGTYSTT--VTGRTC 619 Score = 67.4 bits (163), Expect = 3e-11 Identities = 54/180 (30%), Positives = 73/180 (40%), Gaps = 46/180 (25%) Query: 1 MAPPAARLALLSAAALTLAARPAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFW 60 +APP + +L + AP+ EC+ NG YRGT + T G+ C W Sbjct: 569 VAPPT----VTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVT--GRTCQAW 622 Query: 61 NETFQHPYNTLK--YPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPAC-- 116 + H ++ YPN GL NYCRNPD +P+CY + GV W+YC + C Sbjct: 623 SSMTPHSHSRTPEYYPNA--GL-IMNYCRNPDAVAAPYCYT--RDPGVRWEYCNLTQCSD 677 Query: 117 ---------------------------QMPGNLGCYKDHGNPPPLTGTSKTSNKLTIQTC 149 Q PG CY HGN GT T+ +T +TC Sbjct: 678 AEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECY--HGNGQSYRGTYSTT--VTGRTC 733 Score = 67.4 bits (163), Expect = 3e-11 Identities = 54/180 (30%), Positives = 73/180 (40%), Gaps = 46/180 (25%) Query: 1 MAPPAARLALLSAAALTLAARPAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFW 60 +APP + +L + AP+ EC+ NG YRGT + T G+ C W Sbjct: 683 VAPPT----VTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVT--GRTCQAW 736 Query: 61 NETFQHPYNTLK--YPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPAC-- 116 + H ++ YPN GL NYCRNPD +P+CY + GV W+YC + C Sbjct: 737 SSMTPHSHSRTPEYYPNA--GL-IMNYCRNPDAVAAPYCYT--RDPGVRWEYCNLTQCSD 791 Query: 117 ---------------------------QMPGNLGCYKDHGNPPPLTGTSKTSNKLTIQTC 149 Q PG CY HGN GT T+ +T +TC Sbjct: 792 AEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECY--HGNGQSYRGTYSTT--VTGRTC 847 Score = 67.4 bits (163), Expect = 3e-11 Identities = 37/105 (35%), Positives = 52/105 (49%), Gaps = 9/105 (8%) Query: 14 AALTLAARPAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYN--TL 71 A T + AP+ +C+ +G YRG+ + T G+ C W+ H + T Sbjct: 1254 ATSTAVSEQAPTEQSPTVQDCYHGDGQSYRGSFSTTVT--GRTCQSWSSMTPHWHQRTTE 1311 Query: 72 KYPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPAC 116 YPNG GL NYCRNPD ++ PWCY + V W+YC + C Sbjct: 1312 YYPNG--GL-TRNYCRNPDAEIRPWCYTM--DPSVRWEYCNLTQC 1351 Score = 67.0 bits (162), Expect = 3e-11 Identities = 48/148 (32%), Positives = 63/148 (42%), Gaps = 42/148 (28%) Query: 33 ECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYN--TLKYPNGEGGLGEHNYCRNPD 90 +C+ +G YRGT + T G+ C W+ H +N T YPN GL NYCRNPD Sbjct: 27 DCYHGDGQSYRGTYSTTVT--GRTCQAWSSMTPHQHNRTTENYPNA--GL-IMNYCRNPD 81 Query: 91 GDVSPWCYVAEHEDGVYWKYCEIPAC-----------------------------QMPGN 121 +P+CY + GV W+YC + C Q PG Sbjct: 82 AVAAPYCYT--RDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGV 139 Query: 122 LGCYKDHGNPPPLTGTSKTSNKLTIQTC 149 CY HGN GT T+ +T +TC Sbjct: 140 QECY--HGNGQSYRGTYSTT--VTGRTC 163 Score = 67.0 bits (162), Expect = 3e-11 Identities = 44/116 (37%), Positives = 54/116 (46%), Gaps = 10/116 (8%) Query: 26 PGLGPGPE--CFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNT-LKYPNGEGGLGE 82 P LGP E C NG YRG + T G PC W H ++T + N GL E Sbjct: 1710 PSLGPPSEQDCMFGNGKGYRGKKATTVT--GTPCQEWAAQEPHRHSTFIPGTNKWAGL-E 1766 Query: 83 HNYCRNPDGDVS-PWCYVAEHEDGVYWKYCEIPACQMPGNLGCYKDHGNPPPLTGT 137 NYCRNPDGD++ PWCY + YC+IP C + C K P G+ Sbjct: 1767 KNYCRNPDGDINGPWCYTMNPRK--LFDYCDIPLC-ASSSFDCGKPQVEPKKCPGS 1819 Score = 66.6 bits (161), Expect = 4e-11 Identities = 36/101 (35%), Positives = 50/101 (49%), Gaps = 9/101 (8%) Query: 18 LAARPAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNT--LKYPN 75 L + AP+ +C+ +G YRGT + T G+ C W+ H + L YPN Sbjct: 1372 LPSEEAPTENSTGVQDCYRGDGQSYRGTLSTTIT--GRTCQSWSSMTPHWHRRIPLYYPN 1429 Query: 76 GEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPAC 116 GL NYCRNPD ++ PWCY + V W+YC + C Sbjct: 1430 A--GL-TRNYCRNPDAEIRPWCYTM--DPSVRWEYCNLTRC 1465 Score = 64.3 bits (155), Expect = 2e-10 Identities = 41/116 (35%), Positives = 55/116 (47%), Gaps = 13/116 (11%) Query: 3 PPAARLALLSAAALTLAARPAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFWNE 62 PP LA S A A +PG+ +C+ G YRGT + T G+ C W+ Sbjct: 1027 PPNVILAP-SLEAFFEQALTEETPGV---QDCYYHYGQSYRGTYSTTVT--GRTCQAWSS 1080 Query: 63 TFQHPYNTL--KYPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPAC 116 H ++ YPN GL NYCRNPD ++ PWCY + V W+YC + C Sbjct: 1081 MTPHQHSRTPENYPNA--GL-TRNYCRNPDAEIRPWCYTM--DPSVRWEYCNLTQC 1131 Score = 63.9 bits (154), Expect = 3e-10 Identities = 32/86 (37%), Positives = 43/86 (50%), Gaps = 9/86 (10%) Query: 33 ECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTL--KYPNGEGGLGEHNYCRNPD 90 +C+ NG YRGT + T G+ C W+ H + YPN GL NYCRNPD Sbjct: 1615 QCYHGNGQSYRGTFSTTVT--GRTCQSWSSMTPHRHQRTPENYPND--GL-TMNYCRNPD 1669 Query: 91 GDVSPWCYVAEHEDGVYWKYCEIPAC 116 D PWC+ + + W+YC + C Sbjct: 1670 ADTGPWCFTM--DPSIRWEYCNLTRC 1693 Score = 62.8 bits (151), Expect = 6e-10 Identities = 39/118 (33%), Positives = 55/118 (46%), Gaps = 13/118 (11%) Query: 1 MAPPAARLALLSAAALTLAARPAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFW 60 +APP + +L + AP+ EC+ NG Y+GT T G+ C W Sbjct: 911 VAPPT----ITPIPSLEAPSEQAPTEQRPGVQECYHGNGQSYQGTYFITVT--GRTCQAW 964 Query: 61 NETFQHPYNTLK--YPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPAC 116 + H ++ YPN GL + NYCRNPD +PWCY + V W+YC + C Sbjct: 965 SSMTPHSHSRTPAYYPNA--GLIK-NYCRNPDPVAAPWCYTT--DPSVRWEYCNLTRC 1017 Score = 62.0 bits (149), Expect = 1e-09 Identities = 39/118 (33%), Positives = 55/118 (46%), Gaps = 13/118 (11%) Query: 1 MAPPAARLALLSAAALTLAARPAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFW 60 +APP + +L + AP+ EC+ NG YRGT + T G+ C W Sbjct: 797 VAPPT----VTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVT--GRTCQAW 850 Query: 61 NETFQHPYNTLK--YPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPAC 116 + H ++ YPN GL NYCRNPD +P+CY + V W+YC + C Sbjct: 851 SSMTPHSHSRTPEYYPNA--GL-IMNYCRNPDPVAAPYCYT--RDPSVRWEYCNLTQC 903 Score = 62.0 bits (149), Expect = 1e-09 Identities = 38/107 (35%), Positives = 50/107 (46%), Gaps = 12/107 (11%) Query: 12 SAAALTLAARPAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTL 71 S A + A P SP + +C+ +G YRG + T G+ C W+ H + Sbjct: 1483 STEAPSEQAPPEKSPVV---QDCYHGDGRSYRGISSTTVT--GRTCQSWSSMIPHWHQRT 1537 Query: 72 --KYPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPAC 116 YPN GL E NYCRNPD PWCY + V W+YC + C Sbjct: 1538 PENYPNA--GLTE-NYCRNPDSGKQPWCYTT--DPCVRWEYCNLTQC 1579 >gi|58533165 hepatocyte growth factor isoform 4 precursor [Homo sapiens] Length = 285 Score = 67.8 bits (164), Expect = 2e-11 Identities = 33/85 (38%), Positives = 42/85 (49%), Gaps = 5/85 (5%) Query: 33 ECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPDGD 92 EC T NG YRG + T + GK C W+ H + L + G + NYCRNPDG Sbjct: 205 ECMTCNGESYRGLMDHT--ESGKICQRWDHQTPHRHKFLPERYPDKGFDD-NYCRNPDGQ 261 Query: 93 VSPWCYVAEHEDGVYWKYCEIPACQ 117 PWCY + W+YC I C+ Sbjct: 262 PRPWCYTLDPH--TRWEYCAIKTCE 284 Score = 48.1 bits (113), Expect = 2e-05 Identities = 27/84 (32%), Positives = 40/84 (47%), Gaps = 11/84 (13%) Query: 34 CFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPDGDV 93 C G Y+GT + T + G C W+ H ++ G + NYCRNP G+ Sbjct: 128 CIIGKGRSYKGTVSIT--KSGIKCQPWSSMIPHEHSY------RGKDLQENYCRNPRGEE 179 Query: 94 -SPWCYVAEHEDGVYWKYCEIPAC 116 PWC+ + E V ++ C+IP C Sbjct: 180 GGPWCFTSNPE--VRYEVCDIPQC 201 >gi|58533163 hepatocyte growth factor isoform 2 precursor [Homo sapiens] Length = 290 Score = 67.8 bits (164), Expect = 2e-11 Identities = 33/85 (38%), Positives = 42/85 (49%), Gaps = 5/85 (5%) Query: 33 ECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPDGD 92 EC T NG YRG + T + GK C W+ H + L + G + NYCRNPDG Sbjct: 210 ECMTCNGESYRGLMDHT--ESGKICQRWDHQTPHRHKFLPERYPDKGFDD-NYCRNPDGQ 266 Query: 93 VSPWCYVAEHEDGVYWKYCEIPACQ 117 PWCY + W+YC I C+ Sbjct: 267 PRPWCYTLDPH--TRWEYCAIKTCE 289 Score = 50.8 bits (120), Expect = 2e-06 Identities = 29/85 (34%), Positives = 43/85 (50%), Gaps = 8/85 (9%) Query: 34 CFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLG-EHNYCRNPDGD 92 C G Y+GT + T + G C W+ H ++ L P+ G + NYCRNP G+ Sbjct: 128 CIIGKGRSYKGTVSIT--KSGIKCQPWSSMIPHEHSFL--PSSYRGKDLQENYCRNPRGE 183 Query: 93 V-SPWCYVAEHEDGVYWKYCEIPAC 116 PWC+ + E V ++ C+IP C Sbjct: 184 EGGPWCFTSNPE--VRYEVCDIPQC 206 >gi|145275213 coagulation factor XII precursor [Homo sapiens] Length = 615 Score = 67.8 bits (164), Expect = 2e-11 Identities = 32/86 (37%), Positives = 43/86 (50%), Gaps = 4/86 (4%) Query: 34 CFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPDGDV 93 C+ G YRG T G PC W + T + GLG H +CRNPD D+ Sbjct: 217 CYDGRGLSYRGLARTTL--SGAPCQPWASEATYRNVTAEQARN-WGLGGHAFCRNPDNDI 273 Query: 94 SPWCYVAEHEDGVYWKYCEIPACQMP 119 PWC+V + D + W+YC++ CQ P Sbjct: 274 RPWCFVL-NRDRLSWEYCDLAQCQTP 298 >gi|22035663 lipoprotein, Lp(a)-like 2 precursor [Homo sapiens] Length = 132 Score = 67.4 bits (163), Expect = 3e-11 Identities = 38/103 (36%), Positives = 51/103 (49%), Gaps = 9/103 (8%) Query: 16 LTLAARPAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTL--KY 73 L L + AP+ EC+ +NG YRGT T G+ C W+ H ++ KY Sbjct: 10 LLLFLKSAPTETGPSVQECYHSNGQSYRGTYFTTVT--GRTCQAWSSMTPHQHSRTPEKY 67 Query: 74 PNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPAC 116 PN +G + NYCRNPD PWCY + V W+YC + C Sbjct: 68 PN-DGLIS--NYCRNPDCSAGPWCYTT--DPNVRWEYCNLTRC 105 >gi|13346502 lipoprotein, Lp(a)-like 2 precursor [Homo sapiens] Length = 132 Score = 67.4 bits (163), Expect = 3e-11 Identities = 38/103 (36%), Positives = 51/103 (49%), Gaps = 9/103 (8%) Query: 16 LTLAARPAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTL--KY 73 L L + AP+ EC+ +NG YRGT T G+ C W+ H ++ KY Sbjct: 10 LLLFLKSAPTETGPSVQECYHSNGQSYRGTYFTTVT--GRTCQAWSSMTPHQHSRTPEKY 67 Query: 74 PNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPAC 116 PN +G + NYCRNPD PWCY + V W+YC + C Sbjct: 68 PN-DGLIS--NYCRNPDCSAGPWCYTT--DPNVRWEYCNLTRC 105 >gi|58533170 hepatocyte growth factor isoform 3 precursor [Homo sapiens] Length = 723 Score = 67.0 bits (162), Expect = 3e-11 Identities = 33/84 (39%), Positives = 41/84 (48%), Gaps = 5/84 (5%) Query: 33 ECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPDGD 92 EC T NG YRG + T + GK C W+ H + L + G + NYCRNPDG Sbjct: 205 ECMTCNGESYRGLMDHT--ESGKICQRWDHQTPHRHKFLPERYPDKGFDD-NYCRNPDGQ 261 Query: 93 VSPWCYVAEHEDGVYWKYCEIPAC 116 PWCY + W+YC I C Sbjct: 262 PRPWCYTLDPH--TRWEYCAIKTC 283 Score = 65.9 bits (159), Expect = 8e-11 Identities = 36/98 (36%), Positives = 47/98 (47%), Gaps = 6/98 (6%) Query: 33 ECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPDGD 92 EC G YRGT N + G PC W+ + H ++ L E NYCRNPDG Sbjct: 299 ECIQGQGEGYRGTVN--TIWNGIPCQRWDSQYPHEHDMTPENFKCKDLRE-NYCRNPDGS 355 Query: 93 VSPWCYVAEHEDGVYWKYC-EIPACQMPGNLGCYKDHG 129 SPWC+ + + YC +IP C M CY+ +G Sbjct: 356 ESPWCFTT--DPNIRVGYCSQIPNCDMSHGQDCYRGNG 391 Score = 59.3 bits (142), Expect = 7e-09 Identities = 30/95 (31%), Positives = 45/95 (47%), Gaps = 6/95 (6%) Query: 24 PSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEH 83 P+ + G +C+ NG +Y G N + + G C W++ + + + + L E Sbjct: 376 PNCDMSHGQDCYRGNGKNYMG--NLSQTRSGLTCSMWDKNMEDLHRHIFWEPDASKLNE- 432 Query: 84 NYCRNPDGDV-SPWCYVAEHEDGVYWKYCEIPACQ 117 NYCRNPD D PWCY + W YC I C+ Sbjct: 433 NYCRNPDDDAHGPWCYTG--NPLIPWDYCPISRCE 465 Score = 48.1 bits (113), Expect = 2e-05 Identities = 27/84 (32%), Positives = 40/84 (47%), Gaps = 11/84 (13%) Query: 34 CFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPDGDV 93 C G Y+GT + T + G C W+ H ++ G + NYCRNP G+ Sbjct: 128 CIIGKGRSYKGTVSIT--KSGIKCQPWSSMIPHEHSY------RGKDLQENYCRNPRGEE 179 Query: 94 -SPWCYVAEHEDGVYWKYCEIPAC 116 PWC+ + E V ++ C+IP C Sbjct: 180 GGPWCFTSNPE--VRYEVCDIPQC 201 >gi|33859835 hepatocyte growth factor isoform 1 preproprotein [Homo sapiens] Length = 728 Score = 67.0 bits (162), Expect = 3e-11 Identities = 33/84 (39%), Positives = 41/84 (48%), Gaps = 5/84 (5%) Query: 33 ECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPDGD 92 EC T NG YRG + T + GK C W+ H + L + G + NYCRNPDG Sbjct: 210 ECMTCNGESYRGLMDHT--ESGKICQRWDHQTPHRHKFLPERYPDKGFDD-NYCRNPDGQ 266 Query: 93 VSPWCYVAEHEDGVYWKYCEIPAC 116 PWCY + W+YC I C Sbjct: 267 PRPWCYTLDPH--TRWEYCAIKTC 288 Score = 65.9 bits (159), Expect = 8e-11 Identities = 36/98 (36%), Positives = 47/98 (47%), Gaps = 6/98 (6%) Query: 33 ECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPDGD 92 EC G YRGT N + G PC W+ + H ++ L E NYCRNPDG Sbjct: 304 ECIQGQGEGYRGTVN--TIWNGIPCQRWDSQYPHEHDMTPENFKCKDLRE-NYCRNPDGS 360 Query: 93 VSPWCYVAEHEDGVYWKYC-EIPACQMPGNLGCYKDHG 129 SPWC+ + + YC +IP C M CY+ +G Sbjct: 361 ESPWCFTT--DPNIRVGYCSQIPNCDMSHGQDCYRGNG 396 Score = 59.3 bits (142), Expect = 7e-09 Identities = 30/95 (31%), Positives = 45/95 (47%), Gaps = 6/95 (6%) Query: 24 PSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEH 83 P+ + G +C+ NG +Y G N + + G C W++ + + + + L E Sbjct: 381 PNCDMSHGQDCYRGNGKNYMG--NLSQTRSGLTCSMWDKNMEDLHRHIFWEPDASKLNE- 437 Query: 84 NYCRNPDGDV-SPWCYVAEHEDGVYWKYCEIPACQ 117 NYCRNPD D PWCY + W YC I C+ Sbjct: 438 NYCRNPDDDAHGPWCYTG--NPLIPWDYCPISRCE 470 Score = 50.8 bits (120), Expect = 2e-06 Identities = 29/85 (34%), Positives = 43/85 (50%), Gaps = 8/85 (9%) Query: 34 CFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLG-EHNYCRNPDGD 92 C G Y+GT + T + G C W+ H ++ L P+ G + NYCRNP G+ Sbjct: 128 CIIGKGRSYKGTVSIT--KSGIKCQPWSSMIPHEHSFL--PSSYRGKDLQENYCRNPRGE 183 Query: 93 V-SPWCYVAEHEDGVYWKYCEIPAC 116 PWC+ + E V ++ C+IP C Sbjct: 184 EGGPWCFTSNPE--VRYEVCDIPQC 206 >gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] Length = 3565 Score = 65.5 bits (158), Expect = 1e-10 Identities = 36/126 (28%), Positives = 59/126 (46%), Gaps = 4/126 (3%) Query: 213 VGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVEL 272 + CGG S + V+ SP FP +Y C W I +P H F F + D +E+ Sbjct: 1972 IATCGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEANHDFLEI 2031 Query: 273 LDG--YTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVK-EELPQ 329 +G +T ++ +F G P + + + +++F+SD QGF + YQA + + P Sbjct: 2032 QNGPYHTSPMIGQFSGTDLPAALLSTTHE-TLIHFYSDHSQNRQGFKLAYQAYELQNCPD 2090 Query: 330 ERPAVN 335 P N Sbjct: 2091 PPPFQN 2096 Score = 61.6 bits (148), Expect = 1e-09 Identities = 63/242 (26%), Positives = 98/242 (40%), Gaps = 21/242 (8%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDG 275 CG N ++ + +YSP FPD Y + C W I VP ++ +F L D + + DG Sbjct: 2147 CGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVNDYIAVWDG 2206 Query: 276 --YTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVL-YQAVKEELPQERP 332 L F G + +++ S + V+L F SD N GF VL + A + + Q P Sbjct: 2207 PDQNSPQLGVFSGNTALETAYS-STNQVLLKFHSDFSN--GGFFVLNFHAFQLKKCQPPP 2263 Query: 333 AVNQTVAEVITEQANLSVSAARSSKVLYVITTSPSHPPQTVPGWTVYGLATLLILTVTAI 392 AV Q AE++TE + + HP T+ G + L Sbjct: 2264 AVPQ--AEMLTEDDDFEIGD---------FVKYQCHPGYTLVGTDILTCKLSSQLQFEGS 2312 Query: 393 VAKILLHVTFKSHRVPASGDLRDCHQPG----TSGEIWSIFYKPSTSISIFKKKLKGQSQ 448 + R +SG + PG + WSI +P+ +I+IF + + Q Sbjct: 2313 LPTCEAQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEKQ 2372 Query: 449 QD 450 D Sbjct: 2373 FD 2374 Score = 55.8 bits (133), Expect = 8e-08 Identities = 36/111 (32%), Positives = 55/111 (49%), Gaps = 5/111 (4%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDG 275 CGG Y+ VV SP++P Y G++C ++I VP + F F + D+ EL DG Sbjct: 1626 CGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALN-DLAELFDG 1684 Query: 276 YTH---RVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAV 323 TH R+L+ G + + ++L F + A+GF +YQAV Sbjct: 1685 -THAQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHFVYQAV 1734 Score = 55.1 bits (131), Expect = 1e-07 Identities = 34/129 (26%), Positives = 57/129 (44%), Gaps = 6/129 (4%) Query: 203 DGRIILFDTLV---GACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFP 259 DG ++ T+ CGG+ +A S V+ P +P Y C W I I +F Sbjct: 743 DGNVVWSSTVPRCEAPCGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFD 802 Query: 260 LFDIRDSADMVELLDG--YTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFA 317 F + D +E+ DG + ++ +HG P + +F+ L F +D + GF Sbjct: 803 RFQTEVNYDTLEVRDGPASSSPLIGEYHGTQAPQFLISTG-NFMYLLFTTDNSRSSIGFL 861 Query: 318 VLYQAVKEE 326 + Y++V E Sbjct: 862 IHYESVTLE 870 Score = 55.1 bits (131), Expect = 1e-07 Identities = 33/117 (28%), Positives = 56/117 (47%), Gaps = 1/117 (0%) Query: 211 TLVGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMV 270 T + ACGGN + + V+ SP++P Y G+ C W ++V I F F++ S D + Sbjct: 1447 TCIAACGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPSYDFL 1506 Query: 271 ELLDGY-THRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVKEE 326 + +G ++ L + S+ P S + + L F SD GFA+ ++ E Sbjct: 1507 HIYEGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEKPRE 1563 Score = 51.6 bits (122), Expect = 1e-06 Identities = 34/110 (30%), Positives = 48/110 (43%), Gaps = 3/110 (2%) Query: 213 VGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVEL 272 V +C N++A S ++ SP++P+ Y C W I S IH F FD+ D + + Sbjct: 582 VFSCFFNFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQFDFLAV 641 Query: 273 LDGYTH--RVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLY 320 D VL F G + P S V L F SD +GF + Y Sbjct: 642 KDDGISDITVLGTFSG-NEVPSQLASSGHIVRLEFQSDHSTTGRGFNITY 690 Score = 50.1 bits (118), Expect = 4e-06 Identities = 32/111 (28%), Positives = 47/111 (42%), Gaps = 3/111 (2%) Query: 214 GACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELL 273 GACGG SS + SP FP Y C WTI I F F + + D +E+ Sbjct: 206 GACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEGYDFLEIS 265 Query: 274 DGYTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVK 324 + P +S S +++ L+F SD ++ +GF +Q K Sbjct: 266 GTEAPSIWLTGMNLPSPVIS---SKNWLRLHFTSDSNHRRKGFNAQFQVKK 313 Score = 49.7 bits (117), Expect = 6e-06 Identities = 34/110 (30%), Positives = 49/110 (44%), Gaps = 3/110 (2%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDG 275 C GN++ + SP +P+ Y C W I V S I F + D +E+ DG Sbjct: 1803 CSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQNWDSLEIHDG 1862 Query: 276 --YTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAV 323 T L F G + P L N + + + L+F SD A GF + Y+ V Sbjct: 1863 GDVTAPRLGSFSGTTVPAL-LNSTSNQLYLHFQSDISVAAAGFHLEYKTV 1911 Score = 47.4 bits (111), Expect = 3e-05 Identities = 31/110 (28%), Positives = 48/110 (43%), Gaps = 3/110 (2%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDG 275 CGG + + SP FP Y C W I + I SF F + + D++ + DG Sbjct: 32 CGGLVQGPNGTIESPGFPHGYPNYANCTWIIITGERNRIQLSFHTFALEEDFDILSVYDG 91 Query: 276 YTHR--VLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAV 323 + + R G + P S + + L+F +D AQGF LY+ + Sbjct: 92 QPQQGNLKVRLSG-FQLPSSIVSTGSILTLWFTTDFAVSAQGFKALYEVL 140 Score = 45.8 bits (107), Expect = 8e-05 Identities = 37/122 (30%), Positives = 49/122 (40%), Gaps = 4/122 (3%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELL-D 274 CGG S V SP FPD Y C WTI V + F F + S D + + D Sbjct: 931 CGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESSHDYLLITED 990 Query: 275 GYTHRVLARFHGRSRP-PLSFNVSLDFVI-LYFFSDRINQAQGFAVLYQAVKEELPQERP 332 G +AR G P + + +F L F SD +GF + + E P + P Sbjct: 991 GSFSEPVARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITFSEYDLE-PCDDP 1049 Query: 333 AV 334 V Sbjct: 1050 GV 1051 Score = 44.3 bits (103), Expect = 2e-04 Identities = 34/132 (25%), Positives = 57/132 (43%), Gaps = 5/132 (3%) Query: 194 GDHTQPC-GGDGRII--LFDTLVGACGGN-YSAMSSVVYSPDFPDTYATGRVCYWTIRVP 249 G +T C GD R+ + + CGG ++A S + SP +P Y C W I Sbjct: 1253 GSNTLTCLSGDRRVWDKPLPSCIAECGGQIHAATSGRILSPGYPAPYDNNLHCTWIIEAD 1312 Query: 250 GASHIHFSFPLFDIRDSADMVELLDG-YTHRVLARFHGRSRPPLSFNVSLDFVILYFFSD 308 I F +FD + D++++ DG +L + S P + + + + L F SD Sbjct: 1313 PGKTISLHFIVFDTEMAHDILKVWDGPVDSDILLKEWSGSALPEDIHSTFNSLTLQFDSD 1372 Query: 309 RINQAQGFAVLY 320 GF++ + Sbjct: 1373 FFISKSGFSIQF 1384 Score = 42.7 bits (99), Expect = 7e-04 Identities = 33/115 (28%), Positives = 51/115 (44%), Gaps = 6/115 (5%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASH-IHFSFPLFDIRDSADMVELLD 274 CG N S V+ SP++P Y C W I I +F F++ D + + D Sbjct: 412 CGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGD 471 Query: 275 ----GYTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVKE 325 G T VL G S P L ++S + + L+ SD + GF +YQ +++ Sbjct: 472 AGKVGDTRSVLYVLTGSSVPDLIVSMS-NQMWLHLQSDDSIGSPGFKAVYQEIEK 525 Score = 41.2 bits (95), Expect = 0.002 Identities = 25/101 (24%), Positives = 43/101 (42%), Gaps = 2/101 (1%) Query: 224 SSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDGYTHR--VL 281 S V+ SP +P Y + C W+I+V +I F D +E+ DG + + +L Sbjct: 2330 SGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEKQFDALEVFDGSSGQSPLL 2389 Query: 282 ARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQA 322 G +F + + L + +D +GF + Y A Sbjct: 2390 VVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAA 2430 Score = 40.8 bits (94), Expect = 0.003 Identities = 35/129 (27%), Positives = 52/129 (40%), Gaps = 12/129 (9%) Query: 200 CGGDGRIILFDTL---VGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHF 256 C G GR + L V CG + + SP+FP Y C + I IH Sbjct: 1086 CLGGGRRVWSAPLPRCVAECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHL 1145 Query: 257 ---SFPLFDIRDSADMVELLDG--YTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRIN 311 SF LF+ D +++ DG + R L F L N + + + L F ++ + Sbjct: 1146 RTRSFQLFE----GDTLKVYDGKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGSD 1201 Query: 312 QAQGFAVLY 320 QGF + Y Sbjct: 1202 TDQGFQLTY 1210 >gi|26051243 tumor necrosis factor, alpha-induced protein 6 precursor [Homo sapiens] Length = 277 Score = 65.1 bits (157), Expect = 1e-10 Identities = 39/114 (34%), Positives = 55/114 (48%), Gaps = 7/114 (6%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDS----ADMVE 271 CGG ++ + SP FP+ Y ++CYW IR+ IH SF FD+ D AD VE Sbjct: 135 CGGVFTDPKQIFKSPGFPNEYEDNQICYWHIRLKYGQRIHLSFLDFDLEDDPGCLADYVE 194 Query: 272 LLDGY--THRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAV 323 + D Y H + R+ G P + + + L F SD A GF + Y A+ Sbjct: 195 IYDSYDDVHGFVGRYCGDELPDDIISTG-NVMTLKFLSDASVTAGGFQIKYVAM 247 >gi|222537759 plasminogen activator, urokinase isoform 2 [Homo sapiens] Length = 414 Score = 63.2 bits (152), Expect = 5e-10 Identities = 30/68 (44%), Positives = 38/68 (55%), Gaps = 4/68 (5%) Query: 34 CFTANGADYRGTQNWTALQGGKPCLFWNET--FQHPYNTLKYPNGEGGLGEHNYCRNPDG 91 C+ NG YRG + + G+PCL WN Q Y+ + + GLG+HNYCRNPD Sbjct: 53 CYEGNGHFYRGKASTDTM--GRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDN 110 Query: 92 DVSPWCYV 99 PWCYV Sbjct: 111 RRRPWCYV 118 >gi|4505863 plasminogen activator, urokinase isoform 1 preproprotein [Homo sapiens] Length = 431 Score = 63.2 bits (152), Expect = 5e-10 Identities = 30/68 (44%), Positives = 38/68 (55%), Gaps = 4/68 (5%) Query: 34 CFTANGADYRGTQNWTALQGGKPCLFWNET--FQHPYNTLKYPNGEGGLGEHNYCRNPDG 91 C+ NG YRG + + G+PCL WN Q Y+ + + GLG+HNYCRNPD Sbjct: 70 CYEGNGHFYRGKASTDTM--GRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDN 127 Query: 92 DVSPWCYV 99 PWCYV Sbjct: 128 RRRPWCYV 135 >gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] Length = 3487 Score = 63.2 bits (152), Expect = 5e-10 Identities = 35/111 (31%), Positives = 49/111 (44%), Gaps = 3/111 (2%) Query: 213 VGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVEL 272 + CGG M V+ SP FP Y + C W I +P H F F + D +E+ Sbjct: 1965 IAQCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNHDYIEI 2024 Query: 273 LDG--YTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQ 321 +G T R++ RF G P + S + + YF SD GF + YQ Sbjct: 2025 RNGPYETSRMMGRFSGSELPSSLLSTSHETTV-YFHSDHSQNRPGFKLEYQ 2074 Score = 59.7 bits (143), Expect = 5e-09 Identities = 38/115 (33%), Positives = 54/115 (46%), Gaps = 3/115 (2%) Query: 211 TLVGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMV 270 T V CGGN + + SP FP+ Y C W I VP + I F + D + Sbjct: 1791 TCVVPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSL 1850 Query: 271 ELLDGYTHRV--LARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAV 323 E+ DG + V L F G + P L N + + + L+F+SD A GF + Y+ V Sbjct: 1851 EVFDGADNTVTMLGSFSGTTVPAL-LNSTSNQLYLHFYSDISVSAAGFHLEYKTV 1904 Score = 57.0 bits (136), Expect = 3e-08 Identities = 42/156 (26%), Positives = 72/156 (46%), Gaps = 9/156 (5%) Query: 172 GNNPDYWKYG--EAASTECNSVCFGDHTQPCGGDGRIILFDTLVGACGGNYSAMSSVVYS 229 G++ Y+ +G E T S G +P + R + CGG Y VV S Sbjct: 1577 GSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVC----TAPCGGQYVGSDGVVLS 1632 Query: 230 PDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDGYTH--RVLARFHGR 287 P++P Y +G++C + + VP + F F + D+VE+ DG++ R+L+ G Sbjct: 1633 PNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALN-DVVEVHDGHSQHSRLLSSLSGS 1691 Query: 288 SRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAV 323 + + V++ F + + A+GF +YQAV Sbjct: 1692 HTGESLPLATSNQVLIKFSAKGLAPARGFHFVYQAV 1727 Score = 53.9 bits (128), Expect = 3e-07 Identities = 41/137 (29%), Positives = 60/137 (43%), Gaps = 6/137 (4%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDG 275 CGGN ++ + VYSP FP Y++ + C W I VP + + L S D + + DG Sbjct: 2182 CGGNITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDG 2241 Query: 276 --YTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVKEELPQERPA 333 T L F RS + S + V+L F D FA+ + A L + P Sbjct: 2242 PQQTAPRLGVF-TRSMAKKTVQSSSNQVLLKFHRDAATGGI-FAIAFSAY--PLTKCPPP 2297 Query: 334 VNQTVAEVITEQANLSV 350 AEV+TE ++ Sbjct: 2298 TILPNAEVVTENEEFNI 2314 Score = 53.5 bits (127), Expect = 4e-07 Identities = 32/112 (28%), Positives = 53/112 (47%), Gaps = 3/112 (2%) Query: 211 TLVGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMV 270 T + CGG+ + S V+ SP++P+ Y G+ C W + V I F +F++ D + Sbjct: 1440 TCIAPCGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFL 1499 Query: 271 ELLDG--YTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLY 320 + DG ++ F+G S+ P S + + L F SD GF + Y Sbjct: 1500 HIYDGRDSLSPLIGSFYG-SQLPGRIESSSNSLFLAFRSDASVSNAGFVIDY 1550 Score = 52.4 bits (124), Expect = 9e-07 Identities = 35/111 (31%), Positives = 50/111 (45%), Gaps = 3/111 (2%) Query: 215 ACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLD 274 ACGG S ++ SP FP Y C WTI I F F + D D +E+ Sbjct: 201 ACGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDGYDFLEVTG 260 Query: 275 GYTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVKE 325 T F G S P + S +++ L+F SD ++ +GF+ YQ K+ Sbjct: 261 --TEGSSLWFTGASLPAPVIS-SKNWLRLHFTSDGNHRQRGFSAQYQVKKQ 308 Score = 52.4 bits (124), Expect = 9e-07 Identities = 38/126 (30%), Positives = 56/126 (44%), Gaps = 4/126 (3%) Query: 213 VGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVEL 272 V +C N+++ S VV SP++P+ Y C W I S IH +F D+ D + + Sbjct: 575 VFSCFFNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEPQFDFLVI 634 Query: 273 LDGYTHR--VLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVK-EELPQ 329 DG T VL F G ++ P S S L F +D +GF + + + E P Sbjct: 635 KDGATAEAPVLGTFSG-NQLPSSITSSGHVARLEFQTDHSTGKRGFNITFTTFRHNECPD 693 Query: 330 ERPAVN 335 VN Sbjct: 694 PGVPVN 699 Score = 52.4 bits (124), Expect = 9e-07 Identities = 29/110 (26%), Positives = 52/110 (47%), Gaps = 3/110 (2%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDG 275 CGG+ ++ S + SP +P Y C W I I +F F + D +E+ DG Sbjct: 752 CGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVNYDTLEVRDG 811 Query: 276 --YTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAV 323 Y+ ++ +HG P + S +++ L F +D+ + GF + Y+ + Sbjct: 812 RTYSAPLIGVYHGTQVPQFLISTS-NYLYLLFSTDKSHSDIGFQLRYETI 860 Score = 50.8 bits (120), Expect = 2e-06 Identities = 33/112 (29%), Positives = 48/112 (42%), Gaps = 2/112 (1%) Query: 211 TLVGACGGNYSA-MSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADM 269 T V CGG +S V SP +P Y C WTI I F +FD + D+ Sbjct: 1266 TCVAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVHDV 1325 Query: 270 VELLDGYTHR-VLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLY 320 + + DG VL + P + + + V+L F +D QGFA+ + Sbjct: 1326 LRIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQF 1377 Score = 44.7 bits (104), Expect = 2e-04 Identities = 34/122 (27%), Positives = 50/122 (40%), Gaps = 4/122 (3%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLD- 274 CGG S + SP FPD Y C W I + F+F F + D + + + Sbjct: 924 CGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLITEN 983 Query: 275 GYTHRVLARFHGRSRP-PLSFNVSLDFVI-LYFFSDRINQAQGFAVLYQAVKEELPQERP 332 G + L + G P P+S + +F + F SD +GF + + E P E P Sbjct: 984 GSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYDLE-PCEEP 1042 Query: 333 AV 334 V Sbjct: 1043 EV 1044 Score = 42.7 bits (99), Expect = 7e-04 Identities = 29/108 (26%), Positives = 46/108 (42%), Gaps = 2/108 (1%) Query: 224 SSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDGYTHR--VL 281 + V+ S +P +Y + C W +RV +I + F D E+ DG + + +L Sbjct: 2365 TGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLL 2424 Query: 282 ARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVKEELPQ 329 G PL S + V L + SD +GF + Y A LP+ Sbjct: 2425 KALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSAPYCSLPR 2472 Score = 40.8 bits (94), Expect = 0.003 Identities = 25/112 (22%), Positives = 51/112 (45%), Gaps = 3/112 (2%) Query: 213 VGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVEL 272 V CG + + + SP+FP Y C ++I+ I F++ + D++++ Sbjct: 1095 VAECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSE-GDVLKV 1153 Query: 273 LDGYTH--RVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQA 322 DG + R+L F ++ N + + L F +D N ++GF + + + Sbjct: 1154 YDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSS 1205 Score = 37.7 bits (86), Expect = 0.022 Identities = 30/115 (26%), Positives = 47/115 (40%), Gaps = 6/115 (5%) Query: 216 CGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASH-IHFSFPLFDIRDSADMVEL-- 272 C + S ++ SP+FP Y C W I S I +F FD+ D + + Sbjct: 405 CDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGD 464 Query: 273 --LDGYTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVKE 325 DG VL G S P L + + +L F +D + GF Y+ +++ Sbjct: 465 GGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLL-FQTDGSGSSLGFKASYEEIEQ 518 Score = 37.0 bits (84), Expect = 0.037 Identities = 27/102 (26%), Positives = 39/102 (38%), Gaps = 3/102 (2%) Query: 224 SSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDG--YTHRVL 281 + V SP FP Y C WTI I F F + + D++ + DG + Sbjct: 34 NGTVESPGFPYGYPNYANCTWTITAEEQHRIQLVFQSFALEEDFDVLSVFDGPPQPENLR 93 Query: 282 ARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAV 323 R G P + + + L SD AQGF Y+ + Sbjct: 94 TRLTGFQLPATIVSAATT-LSLRLISDYAVSAQGFHATYEVL 134 >gi|134152686 receptor tyrosine kinase-like orphan receptor 1 isoform 2 [Homo sapiens] Length = 393 Score = 62.0 bits (149), Expect = 1e-09 Identities = 31/87 (35%), Positives = 47/87 (54%), Gaps = 10/87 (11%) Query: 33 ECFTANGADYRGTQNWTALQGGKPCLFWNETF--QHPYNTLKYPNGEGGLGEHNYCRNPD 90 +C+ + G DYRGT + T + G+ C WN + H + L++P GG H+YCRNP Sbjct: 312 KCYNSTGVDYRGTVSVT--KSGRQCQPWNSQYPHTHTFTALRFPELNGG---HSYCRNPG 366 Query: 91 GD-VSPWCYVAEHEDGVYWKYCEIPAC 116 +PWC+ ++ C+IPAC Sbjct: 367 NQKEAPWCFTL--DENFKSDLCDIPAC 391 >gi|134152725 receptor tyrosine kinase-like orphan receptor 1 isoform 1 [Homo sapiens] Length = 937 Score = 62.0 bits (149), Expect = 1e-09 Identities = 31/87 (35%), Positives = 47/87 (54%), Gaps = 10/87 (11%) Query: 33 ECFTANGADYRGTQNWTALQGGKPCLFWNETF--QHPYNTLKYPNGEGGLGEHNYCRNPD 90 +C+ + G DYRGT + T + G+ C WN + H + L++P GG H+YCRNP Sbjct: 312 KCYNSTGVDYRGTVSVT--KSGRQCQPWNSQYPHTHTFTALRFPELNGG---HSYCRNPG 366 Query: 91 GD-VSPWCYVAEHEDGVYWKYCEIPAC 116 +PWC+ ++ C+IPAC Sbjct: 367 NQKEAPWCFTL--DENFKSDLCDIPAC 391 >gi|205277383 macrophage stimulating 1 (hepatocyte growth factor-like) [Homo sapiens] Length = 725 Score = 61.6 bits (148), Expect = 1e-09 Identities = 37/117 (31%), Positives = 58/117 (49%), Gaps = 18/117 (15%) Query: 34 CFTANGADYRGTQNWTALQGGKPCLFWN--ETFQHPYNTLKYPNGEGGLGEHNYCRNPDG 91 C NG +YRG + T + G+ C W+ QHP+ K+ + GL + NYCRNPDG Sbjct: 205 CVWCNGEEYRGAVDRT--ESGRECQRWDLQHPHQHPFEPGKFL--DQGLDD-NYCRNPDG 259 Query: 92 DVSPWCYVAEHEDGVYWKYCEIPAC-------QMPGNLGCYKDHGNPPPLTGTSKTS 141 PWCY + + + ++C++P C Q + C++ G GT+ T+ Sbjct: 260 SERPWCYTTDPQ--IEREFCDLPRCGSEAQPRQEATTVSCFRGKGE--GYRGTANTT 312 Score = 61.2 bits (147), Expect = 2e-09 Identities = 37/93 (39%), Positives = 47/93 (50%), Gaps = 10/93 (10%) Query: 34 CFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTLKY-PNGEGGLGEHNYCRNPDGD 92 C NG YRGT T GG PC W+ F + + KY P GL E N+CRNPDGD Sbjct: 124 CIMNNGVGYRGTMATTV--GGLPCQAWSHKFPNDH---KYTPTLRNGL-EENFCRNPDGD 177 Query: 93 V-SPWCYVAEHEDGVYWKYCEIPACQMPGNLGC 124 PWCY + V ++ C I +C+ + C Sbjct: 178 PGGPWCYTT--DPAVRFQSCGIKSCREAACVWC 208 Score = 52.8 bits (125), Expect = 7e-07 Identities = 26/65 (40%), Positives = 31/65 (47%), Gaps = 3/65 (4%) Query: 34 CFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPDGDV 93 CF G YRGT N T G PC W+ H + L E N+CRNPDG Sbjct: 297 CFRGKGEGYRGTANTTT--AGVPCQRWDAQIPHQHRFTPEKYACKDLRE-NFCRNPDGSE 353 Query: 94 SPWCY 98 +PWC+ Sbjct: 354 APWCF 358 Score = 46.6 bits (109), Expect = 5e-05 Identities = 30/86 (34%), Positives = 41/86 (47%), Gaps = 8/86 (9%) Query: 33 ECFTANGADYRGTQNWTALQGGKPCLFWN-ETFQHPYNTLKYPNGEGGLGEHNYCRNPDG 91 +C+ G YRGT + T + G C W+ ET P T + + E N+CRNPDG Sbjct: 383 DCYHGAGEQYRGTVSKT--RKGVQCQRWSAETPHKPQFT--FTSEPHAQLEENFCRNPDG 438 Query: 92 DV-SPWCYVAEHEDGVYWKYCEIPAC 116 D PWCY + + YC + C Sbjct: 439 DSHGPWCYTMDPR--TPFDYCALRRC 462 >gi|19743898 receptor tyrosine kinase-like orphan receptor 2 precursor [Homo sapiens] Length = 943 Score = 60.1 bits (144), Expect = 4e-09 Identities = 34/98 (34%), Positives = 50/98 (51%), Gaps = 14/98 (14%) Query: 24 PSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPY----NTLKYPNGEGG 79 P+ LG +C+ +G DYRGT + T + G C W QHP+ ++ +P GG Sbjct: 306 PAERLGRYHQCYNGSGMDYRGTASTT--KSGHQCQPW--ALQHPHSHHLSSTDFPELGGG 361 Query: 80 LGEHNYCRNPDGDV-SPWCYVAEHEDGVYWKYCEIPAC 116 H YCRNP G + PWC+ V + C++P+C Sbjct: 362 ---HAYCRNPGGQMEGPWCFT--QNKNVRMELCDVPSC 394 >gi|54792094 WSC domain containing 1 [Homo sapiens] Length = 575 Score = 53.5 bits (127), Expect = 4e-07 Identities = 30/98 (30%), Positives = 45/98 (45%), Gaps = 5/98 (5%) Query: 114 PACQMPGN-LGCYKDHGNPPPLTGTSKTS-NKLTIQTCISFCRSQRFKFAGMESGYACFC 171 PA G +GC+ D G+ L G K+T+ C C + + +AG+E+G C+C Sbjct: 137 PAIHSRGTYIGCFSDDGHERTLKGAVFYDLRKMTVSHCQDACAERSYVYAGLEAGAECYC 196 Query: 172 GNNPDYWKYGEAASTECNSVCFGDHTQPCGGDGRIILF 209 GN G ECN C G+ CG R+ ++ Sbjct: 197 GNRLPAVSVG---LEECNHECKGEKGSVCGAVDRLSVY 231 Score = 29.3 bits (64), Expect = 7.8 Identities = 14/49 (28%), Positives = 23/49 (46%), Gaps = 1/49 (2%) Query: 123 GCYKDHGNPPPLTGTSKTSNKLTIQTCISFCRSQRFKFAGMESGYACFC 171 GC++ N +S +T+ TC FC + F A + G+ C+C Sbjct: 250 GCFRLPENITHAFPSSLIQANVTVGTCSGFCSQKEFPLAILR-GWECYC 297 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.320 0.136 0.441 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 20,760,501 Number of Sequences: 37866 Number of extensions: 1044698 Number of successful extensions: 3379 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 83 Number of HSP's successfully gapped in prelim test: 30 Number of HSP's that attempted gapping in prelim test: 3012 Number of HSP's gapped (non-prelim): 315 length of query: 458 length of database: 18,247,518 effective HSP length: 106 effective length of query: 352 effective length of database: 14,233,722 effective search space: 5010270144 effective search space used: 5010270144 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.