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Search of human proteins with 225579063
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|225579063 solute carrier family 12, member 4 isoform c [Homo
sapiens]
(1087 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|225579063 solute carrier family 12, member 4 isoform c [Homo ... 2191 0.0
gi|225579067 solute carrier family 12, member 4 isoform e [Homo ... 2032 0.0
gi|225579065 solute carrier family 12, member 4 isoform d [Homo ... 2032 0.0
gi|4827006 solute carrier family 12, member 4 isoform a [Homo sa... 2032 0.0
gi|225579061 solute carrier family 12, member 4 isoform b [Homo ... 2015 0.0
gi|110224458 solute carrier family 12, member 6 isoform e [Homo ... 1641 0.0
gi|110224456 solute carrier family 12, member 6 isoform d [Homo ... 1641 0.0
gi|110224454 solute carrier family 12, member 6 isoform c [Homo ... 1641 0.0
gi|110224452 solute carrier family 12, member 6 isoform c [Homo ... 1641 0.0
gi|4826780 solute carrier family 12, member 6 isoform b [Homo sa... 1641 0.0
gi|110224449 solute carrier family 12, member 6 isoform a [Homo ... 1641 0.0
gi|123701900 solute carrier family 12 (potassium/chloride transp... 1473 0.0
gi|198041678 solute carrier family 12 (potassium-chloride transp... 1473 0.0
gi|11968148 solute carrier family 12 (potassium-chloride transpo... 1473 0.0
gi|31881740 solute carrier family 12 (potassium/chloride transpo... 264 4e-70
gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo ... 234 3e-61
gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo ... 231 4e-60
gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo ... 231 4e-60
gi|4506975 solute carrier family 12 (sodium/potassium/chloride t... 231 4e-60
gi|134254459 sodium potassium chloride cotransporter 2 [Homo sap... 212 1e-54
gi|38569457 solute carrier family 12, member 8 [Homo sapiens] 102 3e-21
gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo s... 51 7e-06
gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo s... 47 8e-05
gi|114326550 solute carrier family 7 (cationic amino acid transp... 39 0.020
gi|114326544 solute carrier family 7 (cationic amino acid transp... 39 0.020
gi|4507047 solute carrier family 7 (cationic amino acid transpor... 38 0.046
gi|181337167 solute carrier family 7 (cationic amino acid transp... 36 0.17
gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens] 36 0.23
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 35 0.30
gi|4758646 kinesin family member 3B [Homo sapiens] 35 0.50
>gi|225579063 solute carrier family 12, member 4 isoform c [Homo
sapiens]
Length = 1087
Score = 2191 bits (5676), Expect = 0.0
Identities = 1087/1087 (100%), Positives = 1087/1087 (100%)
Query: 1 MRAGGACRPGAAGTAAGTAAGGWDGGCGGAEPARCLTSPWCQWTGRGAATMTTSRGSVGW 60
MRAGGACRPGAAGTAAGTAAGGWDGGCGGAEPARCLTSPWCQWTGRGAATMTTSRGSVGW
Sbjct: 1 MRAGGACRPGAAGTAAGTAAGGWDGGCGGAEPARCLTSPWCQWTGRGAATMTTSRGSVGW 60
Query: 61 TTGSAPSWMTRTEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSM 120
TTGSAPSWMTRTEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSM
Sbjct: 61 TTGSAPSWMTRTEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSM 120
Query: 121 GTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNG 180
GTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNG
Sbjct: 121 GTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNG 180
Query: 181 VVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPS 240
VVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPS
Sbjct: 181 VVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPS 240
Query: 241 GAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKS 300
GAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKS
Sbjct: 241 GAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKS 300
Query: 301 IFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFM 360
IFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFM
Sbjct: 301 IFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFM 360
Query: 361 LNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIAT 420
LNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIAT
Sbjct: 361 LNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIAT 420
Query: 421 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE 480
SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE
Sbjct: 421 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE 480
Query: 481 GVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNI 540
GVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNI
Sbjct: 481 GVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNI 540
Query: 541 IPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAV 600
IPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAV
Sbjct: 541 IPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAV 600
Query: 601 QTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAE 660
QTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAE
Sbjct: 601 QTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAE 660
Query: 661 KEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQL 720
KEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQL
Sbjct: 661 KEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQL 720
Query: 721 KAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLI 780
KAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLI
Sbjct: 721 KAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLI 780
Query: 781 QSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNH 840
QSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNH
Sbjct: 781 QSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNH 840
Query: 841 ERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVF 900
ERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVF
Sbjct: 841 ERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVF 900
Query: 901 LYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHS 960
LYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHS
Sbjct: 901 LYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHS 960
Query: 961 ALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRR 1020
ALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRR
Sbjct: 961 ALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRR 1020
Query: 1021 MHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGR 1080
MHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGR
Sbjct: 1021 MHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGR 1080
Query: 1081 EVITIYS 1087
EVITIYS
Sbjct: 1081 EVITIYS 1087
>gi|225579067 solute carrier family 12, member 4 isoform e [Homo
sapiens]
Length = 1054
Score = 2032 bits (5265), Expect = 0.0
Identities = 1015/1015 (100%), Positives = 1015/1015 (100%)
Query: 73 EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ 132
EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ
Sbjct: 40 EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ 99
Query: 133 NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS 192
NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS
Sbjct: 100 NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS 159
Query: 193 RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN 252
RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN
Sbjct: 160 RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN 219
Query: 253 MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML 312
MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML
Sbjct: 220 MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML 279
Query: 313 GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 372
GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG
Sbjct: 280 GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 339
Query: 373 AAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPS 432
AAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPS
Sbjct: 340 AAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPS 399
Query: 433 VTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGV 492
VTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGV
Sbjct: 400 VTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGV 459
Query: 493 SRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKV 552
SRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKV
Sbjct: 460 SRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKV 519
Query: 553 NGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPR 612
NGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPR
Sbjct: 520 NGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPR 579
Query: 613 FKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSL 672
FKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSL
Sbjct: 580 FKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSL 639
Query: 673 SAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSV 732
SAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSV
Sbjct: 640 SAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSV 699
Query: 733 IQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNS 792
IQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNS
Sbjct: 700 IQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNS 759
Query: 793 VVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWW 852
VVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWW
Sbjct: 760 VVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWW 819
Query: 853 IVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEV 912
IVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEV
Sbjct: 820 IVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEV 879
Query: 913 VEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEE 972
VEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEE
Sbjct: 880 VEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEE 939
Query: 973 DESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIV 1032
DESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIV
Sbjct: 940 DESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIV 999
Query: 1033 TRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1087
TRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS
Sbjct: 1000 TRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1054
>gi|225579065 solute carrier family 12, member 4 isoform d [Homo
sapiens]
Length = 1079
Score = 2032 bits (5265), Expect = 0.0
Identities = 1015/1015 (100%), Positives = 1015/1015 (100%)
Query: 73 EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ 132
EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ
Sbjct: 65 EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ 124
Query: 133 NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS 192
NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS
Sbjct: 125 NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS 184
Query: 193 RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN 252
RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN
Sbjct: 185 RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN 244
Query: 253 MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML 312
MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML
Sbjct: 245 MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML 304
Query: 313 GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 372
GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG
Sbjct: 305 GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 364
Query: 373 AAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPS 432
AAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPS
Sbjct: 365 AAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPS 424
Query: 433 VTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGV 492
VTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGV
Sbjct: 425 VTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGV 484
Query: 493 SRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKV 552
SRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKV
Sbjct: 485 SRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKV 544
Query: 553 NGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPR 612
NGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPR
Sbjct: 545 NGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPR 604
Query: 613 FKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSL 672
FKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSL
Sbjct: 605 FKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSL 664
Query: 673 SAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSV 732
SAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSV
Sbjct: 665 SAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSV 724
Query: 733 IQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNS 792
IQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNS
Sbjct: 725 IQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNS 784
Query: 793 VVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWW 852
VVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWW
Sbjct: 785 VVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWW 844
Query: 853 IVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEV 912
IVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEV
Sbjct: 845 IVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEV 904
Query: 913 VEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEE 972
VEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEE
Sbjct: 905 VEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEE 964
Query: 973 DESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIV 1032
DESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIV
Sbjct: 965 DESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIV 1024
Query: 1033 TRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1087
TRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS
Sbjct: 1025 TRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1079
>gi|4827006 solute carrier family 12, member 4 isoform a [Homo
sapiens]
Length = 1085
Score = 2032 bits (5265), Expect = 0.0
Identities = 1015/1015 (100%), Positives = 1015/1015 (100%)
Query: 73 EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ 132
EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ
Sbjct: 71 EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ 130
Query: 133 NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS 192
NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS
Sbjct: 131 NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS 190
Query: 193 RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN 252
RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN
Sbjct: 191 RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN 250
Query: 253 MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML 312
MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML
Sbjct: 251 MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML 310
Query: 313 GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 372
GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG
Sbjct: 311 GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 370
Query: 373 AAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPS 432
AAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPS
Sbjct: 371 AAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPS 430
Query: 433 VTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGV 492
VTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGV
Sbjct: 431 VTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGV 490
Query: 493 SRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKV 552
SRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKV
Sbjct: 491 SRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKV 550
Query: 553 NGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPR 612
NGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPR
Sbjct: 551 NGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPR 610
Query: 613 FKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSL 672
FKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSL
Sbjct: 611 FKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSL 670
Query: 673 SAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSV 732
SAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSV
Sbjct: 671 SAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSV 730
Query: 733 IQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNS 792
IQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNS
Sbjct: 731 IQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNS 790
Query: 793 VVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWW 852
VVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWW
Sbjct: 791 VVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWW 850
Query: 853 IVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEV 912
IVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEV
Sbjct: 851 IVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEV 910
Query: 913 VEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEE 972
VEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEE
Sbjct: 911 VEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEE 970
Query: 973 DESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIV 1032
DESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIV
Sbjct: 971 DESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIV 1030
Query: 1033 TRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1087
TRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS
Sbjct: 1031 TRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1085
>gi|225579061 solute carrier family 12, member 4 isoform b [Homo
sapiens]
Length = 1079
Score = 2015 bits (5221), Expect = 0.0
Identities = 1009/1015 (99%), Positives = 1009/1015 (99%), Gaps = 6/1015 (0%)
Query: 73 EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ 132
EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ
Sbjct: 71 EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ 130
Query: 133 NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS 192
NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS
Sbjct: 131 NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS 190
Query: 193 RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN 252
RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN
Sbjct: 191 RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN 250
Query: 253 MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML 312
MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML
Sbjct: 251 MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML 310
Query: 313 GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 372
GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG
Sbjct: 311 GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 370
Query: 373 AAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPS 432
AAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPS
Sbjct: 371 AAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPS 430
Query: 433 VTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGV 492
VTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGV
Sbjct: 431 VTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGV 490
Query: 493 SRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKV 552
SRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKV
Sbjct: 491 SRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKV 550
Query: 553 NGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPR 612
NGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPR
Sbjct: 551 NGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPR 610
Query: 613 FKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSL 672
FKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSL
Sbjct: 611 FKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSL 670
Query: 673 SAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSV 732
SAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSV
Sbjct: 671 SAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSV 730
Query: 733 IQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNS 792
IQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNS
Sbjct: 731 IQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNS 790
Query: 793 VVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWW 852
VVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWW
Sbjct: 791 VVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWW 850
Query: 853 IVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEV 912
IVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAE
Sbjct: 851 IVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAE--- 907
Query: 913 VEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEE 972
HNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEE
Sbjct: 908 ---HNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEE 964
Query: 973 DESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIV 1032
DESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIV
Sbjct: 965 DESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIV 1024
Query: 1033 TRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1087
TRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS
Sbjct: 1025 TRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1079
>gi|110224458 solute carrier family 12, member 6 isoform e [Homo
sapiens]
Length = 1135
Score = 1641 bits (4250), Expect = 0.0
Identities = 809/1016 (79%), Positives = 905/1016 (89%), Gaps = 4/1016 (0%)
Query: 73 EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ 132
EE+D RPKVSSLL ++ +YTNLTQGAKEHEEAE+ +++ + P MGT MGVYLPCLQ
Sbjct: 123 EEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQ 182
Query: 133 NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS 192
NIFGVILFLRLTW+VGTAGVLQA IVLICCCCT+LTAISMSAIATNGVVPAGGSYFMIS
Sbjct: 183 NIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMIS 242
Query: 193 RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN 252
R+LGPEFGGAVGLCFYLGTTFAAAMYILGAIEI L YI P AAIF+ A S A LNN
Sbjct: 243 RALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNN 302
Query: 253 MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML 312
MRVYGT FL M LVVF+GV+YVNKFASLFLACVI+SIL+IYAG IKS F PP FPVCML
Sbjct: 303 MRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCML 362
Query: 313 GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 372
GNRTLS D+C+KT ++N TV ++LW FFC+S +CD YF+ NNVT I GIPG
Sbjct: 363 GNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPG 422
Query: 373 AAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPL-YVVADIATSFTVLVGIFFP 431
A+G++ ENLWS YL KG+I+EK PSA + + SL YV+ DI TSFT+LVGIFFP
Sbjct: 423 LASGIITENLWSNYLPKGEIIEK---PSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFP 479
Query: 432 SVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDG 491
SVTGIMAGSNRSGDL+DAQKSIP+GTILAI+TTS VY S+VVLFGACIEGVVLRDK+GD
Sbjct: 480 SVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDA 539
Query: 492 VSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK 551
V NLVVGTL+WPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGH K
Sbjct: 540 VKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSK 599
Query: 552 VNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRP 611
NGEPTWALLLTA IAELGILIASLD+VAPILSMFFLMCYLFVNLACA+QTLLRTPNWRP
Sbjct: 600 ANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRP 659
Query: 612 RFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLS 671
RF+YYHWALSF+GMS+CLALMF+SSWYYA+VAM+IAGMIYKYIEYQGAEKEWGDGIRGLS
Sbjct: 660 RFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLS 719
Query: 672 LSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGS 731
LSAAR+ALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVK+PRLLTFASQLKAGKGLTIVGS
Sbjct: 720 LSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGS 779
Query: 732 VIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHN 791
VI G+FLE+YGEA AAEQTIK++ME EKVKGFCQ+VVA+K+REG++HLIQSCGLGGM+HN
Sbjct: 780 VIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHN 839
Query: 792 SVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVW 851
+VV+GWP GWRQSED RAWKTFI TVR TTAAHLALLV KNI+F+PSN E++ EG+IDVW
Sbjct: 840 TVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVW 899
Query: 852 WIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVE 911
WIVHDGGMLMLLPFLL+QHKVWRKC +RIFTVAQ++DNSIQMKKDLA FLYHLR+EAEVE
Sbjct: 900 WIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVE 959
Query: 912 VVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDE 971
VVEMH+SDISAYTYERTLMMEQRSQMLR MRL+KTER+REAQLVKDR+S LRL S+ SDE
Sbjct: 960 VVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDE 1019
Query: 972 EDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVI 1031
++E+ +K+ MTWT+DKYM + + + F++L++++PDQSNVRRMHTAVKLNEVI
Sbjct: 1020 DEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVI 1079
Query: 1032 VTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1087
V +SH+A+LVLLNMPGPPRN EGDENYMEFLEVLTEGLERVLLVRGGG EVITIYS
Sbjct: 1080 VNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1135
>gi|110224456 solute carrier family 12, member 6 isoform d [Homo
sapiens]
Length = 1141
Score = 1641 bits (4250), Expect = 0.0
Identities = 809/1016 (79%), Positives = 905/1016 (89%), Gaps = 4/1016 (0%)
Query: 73 EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ 132
EE+D RPKVSSLL ++ +YTNLTQGAKEHEEAE+ +++ + P MGT MGVYLPCLQ
Sbjct: 129 EEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQ 188
Query: 133 NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS 192
NIFGVILFLRLTW+VGTAGVLQA IVLICCCCT+LTAISMSAIATNGVVPAGGSYFMIS
Sbjct: 189 NIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMIS 248
Query: 193 RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN 252
R+LGPEFGGAVGLCFYLGTTFAAAMYILGAIEI L YI P AAIF+ A S A LNN
Sbjct: 249 RALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNN 308
Query: 253 MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML 312
MRVYGT FL M LVVF+GV+YVNKFASLFLACVI+SIL+IYAG IKS F PP FPVCML
Sbjct: 309 MRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCML 368
Query: 313 GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 372
GNRTLS D+C+KT ++N TV ++LW FFC+S +CD YF+ NNVT I GIPG
Sbjct: 369 GNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPG 428
Query: 373 AAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPL-YVVADIATSFTVLVGIFFP 431
A+G++ ENLWS YL KG+I+EK PSA + + SL YV+ DI TSFT+LVGIFFP
Sbjct: 429 LASGIITENLWSNYLPKGEIIEK---PSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFP 485
Query: 432 SVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDG 491
SVTGIMAGSNRSGDL+DAQKSIP+GTILAI+TTS VY S+VVLFGACIEGVVLRDK+GD
Sbjct: 486 SVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDA 545
Query: 492 VSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK 551
V NLVVGTL+WPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGH K
Sbjct: 546 VKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSK 605
Query: 552 VNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRP 611
NGEPTWALLLTA IAELGILIASLD+VAPILSMFFLMCYLFVNLACA+QTLLRTPNWRP
Sbjct: 606 ANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRP 665
Query: 612 RFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLS 671
RF+YYHWALSF+GMS+CLALMF+SSWYYA+VAM+IAGMIYKYIEYQGAEKEWGDGIRGLS
Sbjct: 666 RFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLS 725
Query: 672 LSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGS 731
LSAAR+ALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVK+PRLLTFASQLKAGKGLTIVGS
Sbjct: 726 LSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGS 785
Query: 732 VIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHN 791
VI G+FLE+YGEA AAEQTIK++ME EKVKGFCQ+VVA+K+REG++HLIQSCGLGGM+HN
Sbjct: 786 VIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHN 845
Query: 792 SVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVW 851
+VV+GWP GWRQSED RAWKTFI TVR TTAAHLALLV KNI+F+PSN E++ EG+IDVW
Sbjct: 846 TVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVW 905
Query: 852 WIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVE 911
WIVHDGGMLMLLPFLL+QHKVWRKC +RIFTVAQ++DNSIQMKKDLA FLYHLR+EAEVE
Sbjct: 906 WIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVE 965
Query: 912 VVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDE 971
VVEMH+SDISAYTYERTLMMEQRSQMLR MRL+KTER+REAQLVKDR+S LRL S+ SDE
Sbjct: 966 VVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDE 1025
Query: 972 EDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVI 1031
++E+ +K+ MTWT+DKYM + + + F++L++++PDQSNVRRMHTAVKLNEVI
Sbjct: 1026 DEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVI 1085
Query: 1032 VTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1087
V +SH+A+LVLLNMPGPPRN EGDENYMEFLEVLTEGLERVLLVRGGG EVITIYS
Sbjct: 1086 VNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1141
>gi|110224454 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 1641 bits (4250), Expect = 0.0
Identities = 809/1016 (79%), Positives = 905/1016 (89%), Gaps = 4/1016 (0%)
Query: 73 EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ 132
EE+D RPKVSSLL ++ +YTNLTQGAKEHEEAE+ +++ + P MGT MGVYLPCLQ
Sbjct: 79 EEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQ 138
Query: 133 NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS 192
NIFGVILFLRLTW+VGTAGVLQA IVLICCCCT+LTAISMSAIATNGVVPAGGSYFMIS
Sbjct: 139 NIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMIS 198
Query: 193 RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN 252
R+LGPEFGGAVGLCFYLGTTFAAAMYILGAIEI L YI P AAIF+ A S A LNN
Sbjct: 199 RALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNN 258
Query: 253 MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML 312
MRVYGT FL M LVVF+GV+YVNKFASLFLACVI+SIL+IYAG IKS F PP FPVCML
Sbjct: 259 MRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCML 318
Query: 313 GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 372
GNRTLS D+C+KT ++N TV ++LW FFC+S +CD YF+ NNVT I GIPG
Sbjct: 319 GNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPG 378
Query: 373 AAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPL-YVVADIATSFTVLVGIFFP 431
A+G++ ENLWS YL KG+I+EK PSA + + SL YV+ DI TSFT+LVGIFFP
Sbjct: 379 LASGIITENLWSNYLPKGEIIEK---PSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFP 435
Query: 432 SVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDG 491
SVTGIMAGSNRSGDL+DAQKSIP+GTILAI+TTS VY S+VVLFGACIEGVVLRDK+GD
Sbjct: 436 SVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDA 495
Query: 492 VSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK 551
V NLVVGTL+WPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGH K
Sbjct: 496 VKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSK 555
Query: 552 VNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRP 611
NGEPTWALLLTA IAELGILIASLD+VAPILSMFFLMCYLFVNLACA+QTLLRTPNWRP
Sbjct: 556 ANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRP 615
Query: 612 RFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLS 671
RF+YYHWALSF+GMS+CLALMF+SSWYYA+VAM+IAGMIYKYIEYQGAEKEWGDGIRGLS
Sbjct: 616 RFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLS 675
Query: 672 LSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGS 731
LSAAR+ALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVK+PRLLTFASQLKAGKGLTIVGS
Sbjct: 676 LSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGS 735
Query: 732 VIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHN 791
VI G+FLE+YGEA AAEQTIK++ME EKVKGFCQ+VVA+K+REG++HLIQSCGLGGM+HN
Sbjct: 736 VIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHN 795
Query: 792 SVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVW 851
+VV+GWP GWRQSED RAWKTFI TVR TTAAHLALLV KNI+F+PSN E++ EG+IDVW
Sbjct: 796 TVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVW 855
Query: 852 WIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVE 911
WIVHDGGMLMLLPFLL+QHKVWRKC +RIFTVAQ++DNSIQMKKDLA FLYHLR+EAEVE
Sbjct: 856 WIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVE 915
Query: 912 VVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDE 971
VVEMH+SDISAYTYERTLMMEQRSQMLR MRL+KTER+REAQLVKDR+S LRL S+ SDE
Sbjct: 916 VVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDE 975
Query: 972 EDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVI 1031
++E+ +K+ MTWT+DKYM + + + F++L++++PDQSNVRRMHTAVKLNEVI
Sbjct: 976 DEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVI 1035
Query: 1032 VTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1087
V +SH+A+LVLLNMPGPPRN EGDENYMEFLEVLTEGLERVLLVRGGG EVITIYS
Sbjct: 1036 VNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1091
>gi|110224452 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 1641 bits (4250), Expect = 0.0
Identities = 809/1016 (79%), Positives = 905/1016 (89%), Gaps = 4/1016 (0%)
Query: 73 EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ 132
EE+D RPKVSSLL ++ +YTNLTQGAKEHEEAE+ +++ + P MGT MGVYLPCLQ
Sbjct: 79 EEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQ 138
Query: 133 NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS 192
NIFGVILFLRLTW+VGTAGVLQA IVLICCCCT+LTAISMSAIATNGVVPAGGSYFMIS
Sbjct: 139 NIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMIS 198
Query: 193 RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN 252
R+LGPEFGGAVGLCFYLGTTFAAAMYILGAIEI L YI P AAIF+ A S A LNN
Sbjct: 199 RALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNN 258
Query: 253 MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML 312
MRVYGT FL M LVVF+GV+YVNKFASLFLACVI+SIL+IYAG IKS F PP FPVCML
Sbjct: 259 MRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCML 318
Query: 313 GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 372
GNRTLS D+C+KT ++N TV ++LW FFC+S +CD YF+ NNVT I GIPG
Sbjct: 319 GNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPG 378
Query: 373 AAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPL-YVVADIATSFTVLVGIFFP 431
A+G++ ENLWS YL KG+I+EK PSA + + SL YV+ DI TSFT+LVGIFFP
Sbjct: 379 LASGIITENLWSNYLPKGEIIEK---PSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFP 435
Query: 432 SVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDG 491
SVTGIMAGSNRSGDL+DAQKSIP+GTILAI+TTS VY S+VVLFGACIEGVVLRDK+GD
Sbjct: 436 SVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDA 495
Query: 492 VSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK 551
V NLVVGTL+WPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGH K
Sbjct: 496 VKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSK 555
Query: 552 VNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRP 611
NGEPTWALLLTA IAELGILIASLD+VAPILSMFFLMCYLFVNLACA+QTLLRTPNWRP
Sbjct: 556 ANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRP 615
Query: 612 RFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLS 671
RF+YYHWALSF+GMS+CLALMF+SSWYYA+VAM+IAGMIYKYIEYQGAEKEWGDGIRGLS
Sbjct: 616 RFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLS 675
Query: 672 LSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGS 731
LSAAR+ALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVK+PRLLTFASQLKAGKGLTIVGS
Sbjct: 676 LSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGS 735
Query: 732 VIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHN 791
VI G+FLE+YGEA AAEQTIK++ME EKVKGFCQ+VVA+K+REG++HLIQSCGLGGM+HN
Sbjct: 736 VIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHN 795
Query: 792 SVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVW 851
+VV+GWP GWRQSED RAWKTFI TVR TTAAHLALLV KNI+F+PSN E++ EG+IDVW
Sbjct: 796 TVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVW 855
Query: 852 WIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVE 911
WIVHDGGMLMLLPFLL+QHKVWRKC +RIFTVAQ++DNSIQMKKDLA FLYHLR+EAEVE
Sbjct: 856 WIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVE 915
Query: 912 VVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDE 971
VVEMH+SDISAYTYERTLMMEQRSQMLR MRL+KTER+REAQLVKDR+S LRL S+ SDE
Sbjct: 916 VVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDE 975
Query: 972 EDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVI 1031
++E+ +K+ MTWT+DKYM + + + F++L++++PDQSNVRRMHTAVKLNEVI
Sbjct: 976 DEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVI 1035
Query: 1032 VTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1087
V +SH+A+LVLLNMPGPPRN EGDENYMEFLEVLTEGLERVLLVRGGG EVITIYS
Sbjct: 1036 VNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1091
>gi|4826780 solute carrier family 12, member 6 isoform b [Homo
sapiens]
Length = 1099
Score = 1641 bits (4250), Expect = 0.0
Identities = 809/1016 (79%), Positives = 905/1016 (89%), Gaps = 4/1016 (0%)
Query: 73 EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ 132
EE+D RPKVSSLL ++ +YTNLTQGAKEHEEAE+ +++ + P MGT MGVYLPCLQ
Sbjct: 87 EEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQ 146
Query: 133 NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS 192
NIFGVILFLRLTW+VGTAGVLQA IVLICCCCT+LTAISMSAIATNGVVPAGGSYFMIS
Sbjct: 147 NIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMIS 206
Query: 193 RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN 252
R+LGPEFGGAVGLCFYLGTTFAAAMYILGAIEI L YI P AAIF+ A S A LNN
Sbjct: 207 RALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNN 266
Query: 253 MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML 312
MRVYGT FL M LVVF+GV+YVNKFASLFLACVI+SIL+IYAG IKS F PP FPVCML
Sbjct: 267 MRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCML 326
Query: 313 GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 372
GNRTLS D+C+KT ++N TV ++LW FFC+S +CD YF+ NNVT I GIPG
Sbjct: 327 GNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPG 386
Query: 373 AAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPL-YVVADIATSFTVLVGIFFP 431
A+G++ ENLWS YL KG+I+EK PSA + + SL YV+ DI TSFT+LVGIFFP
Sbjct: 387 LASGIITENLWSNYLPKGEIIEK---PSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFP 443
Query: 432 SVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDG 491
SVTGIMAGSNRSGDL+DAQKSIP+GTILAI+TTS VY S+VVLFGACIEGVVLRDK+GD
Sbjct: 444 SVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDA 503
Query: 492 VSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK 551
V NLVVGTL+WPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGH K
Sbjct: 504 VKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSK 563
Query: 552 VNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRP 611
NGEPTWALLLTA IAELGILIASLD+VAPILSMFFLMCYLFVNLACA+QTLLRTPNWRP
Sbjct: 564 ANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRP 623
Query: 612 RFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLS 671
RF+YYHWALSF+GMS+CLALMF+SSWYYA+VAM+IAGMIYKYIEYQGAEKEWGDGIRGLS
Sbjct: 624 RFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLS 683
Query: 672 LSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGS 731
LSAAR+ALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVK+PRLLTFASQLKAGKGLTIVGS
Sbjct: 684 LSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGS 743
Query: 732 VIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHN 791
VI G+FLE+YGEA AAEQTIK++ME EKVKGFCQ+VVA+K+REG++HLIQSCGLGGM+HN
Sbjct: 744 VIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHN 803
Query: 792 SVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVW 851
+VV+GWP GWRQSED RAWKTFI TVR TTAAHLALLV KNI+F+PSN E++ EG+IDVW
Sbjct: 804 TVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVW 863
Query: 852 WIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVE 911
WIVHDGGMLMLLPFLL+QHKVWRKC +RIFTVAQ++DNSIQMKKDLA FLYHLR+EAEVE
Sbjct: 864 WIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVE 923
Query: 912 VVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDE 971
VVEMH+SDISAYTYERTLMMEQRSQMLR MRL+KTER+REAQLVKDR+S LRL S+ SDE
Sbjct: 924 VVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDE 983
Query: 972 EDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVI 1031
++E+ +K+ MTWT+DKYM + + + F++L++++PDQSNVRRMHTAVKLNEVI
Sbjct: 984 DEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVI 1043
Query: 1032 VTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1087
V +SH+A+LVLLNMPGPPRN EGDENYMEFLEVLTEGLERVLLVRGGG EVITIYS
Sbjct: 1044 VNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1099
>gi|110224449 solute carrier family 12, member 6 isoform a [Homo
sapiens]
Length = 1150
Score = 1641 bits (4250), Expect = 0.0
Identities = 809/1016 (79%), Positives = 905/1016 (89%), Gaps = 4/1016 (0%)
Query: 73 EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ 132
EE+D RPKVSSLL ++ +YTNLTQGAKEHEEAE+ +++ + P MGT MGVYLPCLQ
Sbjct: 138 EEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQ 197
Query: 133 NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS 192
NIFGVILFLRLTW+VGTAGVLQA IVLICCCCT+LTAISMSAIATNGVVPAGGSYFMIS
Sbjct: 198 NIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMIS 257
Query: 193 RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN 252
R+LGPEFGGAVGLCFYLGTTFAAAMYILGAIEI L YI P AAIF+ A S A LNN
Sbjct: 258 RALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNN 317
Query: 253 MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML 312
MRVYGT FL M LVVF+GV+YVNKFASLFLACVI+SIL+IYAG IKS F PP FPVCML
Sbjct: 318 MRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCML 377
Query: 313 GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 372
GNRTLS D+C+KT ++N TV ++LW FFC+S +CD YF+ NNVT I GIPG
Sbjct: 378 GNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPG 437
Query: 373 AAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPL-YVVADIATSFTVLVGIFFP 431
A+G++ ENLWS YL KG+I+EK PSA + + SL YV+ DI TSFT+LVGIFFP
Sbjct: 438 LASGIITENLWSNYLPKGEIIEK---PSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFP 494
Query: 432 SVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDG 491
SVTGIMAGSNRSGDL+DAQKSIP+GTILAI+TTS VY S+VVLFGACIEGVVLRDK+GD
Sbjct: 495 SVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDA 554
Query: 492 VSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK 551
V NLVVGTL+WPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGH K
Sbjct: 555 VKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSK 614
Query: 552 VNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRP 611
NGEPTWALLLTA IAELGILIASLD+VAPILSMFFLMCYLFVNLACA+QTLLRTPNWRP
Sbjct: 615 ANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRP 674
Query: 612 RFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLS 671
RF+YYHWALSF+GMS+CLALMF+SSWYYA+VAM+IAGMIYKYIEYQGAEKEWGDGIRGLS
Sbjct: 675 RFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLS 734
Query: 672 LSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGS 731
LSAAR+ALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVK+PRLLTFASQLKAGKGLTIVGS
Sbjct: 735 LSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGS 794
Query: 732 VIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHN 791
VI G+FLE+YGEA AAEQTIK++ME EKVKGFCQ+VVA+K+REG++HLIQSCGLGGM+HN
Sbjct: 795 VIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHN 854
Query: 792 SVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVW 851
+VV+GWP GWRQSED RAWKTFI TVR TTAAHLALLV KNI+F+PSN E++ EG+IDVW
Sbjct: 855 TVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVW 914
Query: 852 WIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVE 911
WIVHDGGMLMLLPFLL+QHKVWRKC +RIFTVAQ++DNSIQMKKDLA FLYHLR+EAEVE
Sbjct: 915 WIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVE 974
Query: 912 VVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDE 971
VVEMH+SDISAYTYERTLMMEQRSQMLR MRL+KTER+REAQLVKDR+S LRL S+ SDE
Sbjct: 975 VVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDE 1034
Query: 972 EDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVI 1031
++E+ +K+ MTWT+DKYM + + + F++L++++PDQSNVRRMHTAVKLNEVI
Sbjct: 1035 DEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVI 1094
Query: 1032 VTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1087
V +SH+A+LVLLNMPGPPRN EGDENYMEFLEVLTEGLERVLLVRGGG EVITIYS
Sbjct: 1095 VNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1150
>gi|123701900 solute carrier family 12 (potassium/chloride
transporters), member 7 [Homo sapiens]
Length = 1083
Score = 1473 bits (3814), Expect = 0.0
Identities = 731/1018 (71%), Positives = 843/1018 (82%), Gaps = 11/1018 (1%)
Query: 73 EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ 132
EE+D P VSSLL KL +YTNL+QG EHEE E +RRR A+AP MGT +GVYLPCLQ
Sbjct: 74 EEMDSNPMVSSLLNKLANYTNLSQGVVEHEEDEE---SRRREAKAPRMGTFIGVYLPCLQ 130
Query: 133 NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS 192
NI GVILFLRLTW+VG AGVL++ LIV +CC CT+LTAISMSAIATNGVVPAGGSY+MIS
Sbjct: 131 NILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMIS 190
Query: 193 RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN 252
RSLGPEFGGAVGLCFYLGTTFA AMYILG IEI LTYI+P AAIF A + A L+N
Sbjct: 191 RSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIFQAEAAGGEAAAMLHN 250
Query: 253 MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML 312
MRVYGT L M LVVFVGVKYVNK A +FLACV++SIL+IYAG IKS FDPP PVC+L
Sbjct: 251 MRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKSAFDPPDIPVCLL 310
Query: 313 GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 372
GNRTLSR FD C K + N + + LW FC+ + +CD YF+ NNVTEI GIPG
Sbjct: 311 GNRTLSRRSFDACVKAYGIHNNSATSALWGLFCNGSQPSA-ACDEYFIQNNVTEIQGIPG 369
Query: 373 AAAGVLQENLWSAYLEKGDIVEKHGLPSADAP--SLKESLPLYVVADIATSFTVLVGIFF 430
AA+GV ENLWS Y G VEK G+PS S +LP YV+ DIA SFT+LVGI+F
Sbjct: 370 AASGVFLENLWSTYAHAGAFVEKKGVPSVPVAEESRASALP-YVLTDIAASFTLLVGIYF 428
Query: 431 PSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGD 490
PSVTGIMAGSNRSGDL+DAQKSIP GTILAI+TTS +Y S +VLFGACIEGVVLRDK+G+
Sbjct: 429 PSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGE 488
Query: 491 GVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHG 550
+ NLV+G LAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIA+D I+PFL+VFGHG
Sbjct: 489 ALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHG 548
Query: 551 KVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWR 610
K NGEPTWALLLT LI E GILIASLD VAPILSMFFLMCYLFVNLACAVQTLLRTPNWR
Sbjct: 549 KANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLFVNLACAVQTLLRTPNWR 608
Query: 611 PRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGL 670
PRFK+YHW LSFLGMSLCLALMF+ SWYYAL AMLIAG IYKYIEY+GAEKEWGDGIRGL
Sbjct: 609 PRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGL 668
Query: 671 SLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVG 730
SL+AARYALLR+E GPPHTKNWRPQ+LV+L LD + VK+PRLL+F SQLKAGKGLTIVG
Sbjct: 669 SLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVG 728
Query: 731 SVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRH 790
SV++G++L+ + EAQ AE+ I+++M EK KGFCQ+VV+S +R+G++HLIQS GLGG++H
Sbjct: 729 SVLEGTYLDKHMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKH 788
Query: 791 NSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDV 850
N+V++ WP W+Q ++P +WK F+DTVR TTAAH ALLV KN+ +P N ER+ GHIDV
Sbjct: 789 NTVLMAWPASWKQEDNPFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQNQERFGGGHIDV 848
Query: 851 WWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEV 910
WWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQ+DDNSIQMKKDL +FLYHLR+ AEV
Sbjct: 849 WWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEV 908
Query: 911 EVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSD 970
EVVEM +DISA+TYERTLMMEQRSQML+QM+L+K E+EREAQL+ DR++A +
Sbjct: 909 EVVEMVENDISAFTYERTLMMEQRSQMLKQMQLSKNEQEREAQLIHDRNTASHTAAA--- 965
Query: 971 EEDESAVGADKIQMTWTRDKYMTETW-DPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNE 1029
++ DK+QMTWTR+K + E + + F++L +KPDQSNVRRMHTAVKLN
Sbjct: 966 ARTQAPPTPDKVQMTWTREKLIAEKYRSRDTSLSGFKDLFSMKPDQSNVRRMHTAVKLNG 1025
Query: 1030 VIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1087
V++ +S DA+LVLLNMPGPP+N +GDENYMEFLEVLTEGL RVLLVRGGGREVITIYS
Sbjct: 1026 VVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVITIYS 1083
>gi|198041678 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 1 [Homo sapiens]
Length = 1139
Score = 1473 bits (3813), Expect = 0.0
Identities = 745/1069 (69%), Positives = 860/1069 (80%), Gaps = 56/1069 (5%)
Query: 73 EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ 132
EE+D P VSSLL L +YTNL QG++EHEEAE+ EG +++ +AP MGT MGVYLPCLQ
Sbjct: 73 EEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQ 132
Query: 133 NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS 192
NIFGVILFLRLTW+VG AG++++ +V ICC CT+LTAISMSAIATNGVVPAGGSY+MIS
Sbjct: 133 NIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMIS 192
Query: 193 RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN 252
RSLGPEFGGAVGLCFYLGTTFA AMYILG IEILL Y+ P AIF A + A LNN
Sbjct: 193 RSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNN 252
Query: 253 MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML 312
MRVYGT LT M VVFVGVKYVNKFA +FL CVI+SIL+IYAG IKS FDPP FP+C+L
Sbjct: 253 MRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLL 312
Query: 313 GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 372
GNRTLSR FD+CAK A NETV T+LW FC S L +CD YF NNVTEI GIPG
Sbjct: 313 GNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNA-TCDEYFTRNNVTEIQGIPG 371
Query: 373 AAAGVLQENLWSAYLEKGDIVEKHGLPS---ADAPSLKESLPLYVVADIATSFTVLVGIF 429
AA+G+++ENLWS+YL KG IVE+ G+ S AD + P YV +D+ + FT+LVGI+
Sbjct: 372 AASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHP-YVFSDMTSYFTLLVGIY 430
Query: 430 FPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYG 489
FPSVTGIMAGSNRSGDLRDAQKSIP GTILAI TTS VY SSVVLFGACIEGVVLRDK+G
Sbjct: 431 FPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFG 490
Query: 490 DGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGH 549
+ V+ NLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAI++D I+PFL+VFGH
Sbjct: 491 EAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGH 550
Query: 550 GKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNW 609
GK NGEPTWALLLTA I E+GILIASLD VAPILSMFFLMCY+FVNLACAVQTLLRTPNW
Sbjct: 551 GKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNW 610
Query: 610 RPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRG 669
RPRF+YYHW LSFLGMSLCLALMF+ SWYYALVAMLIAG+IYKYIEY+GAEKEWGDGIRG
Sbjct: 611 RPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRG 670
Query: 670 LSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIV 729
LSLSAARYALLRLEEGPPHTKNWRPQLLVL+++D+D +V +P+LL+ SQLKAGKGLTIV
Sbjct: 671 LSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIV 730
Query: 730 GSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMR 789
GSV++G+FLE++ +AQ AE++I+ +ME EKVKGFCQVV++S +R+G++HLIQS GLGG++
Sbjct: 731 GSVLEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQ 790
Query: 790 HNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHID 849
HN+V++GWP WRQ ED + W+ FI+ VR TTA HLALLV KN++ +P N ER+ EG ID
Sbjct: 791 HNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSID 850
Query: 850 VWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAE 909
VWWIVHDGGMLMLLPFLLR HKVWRKC+MRIFTVAQMDDNSIQMKKDL FLYHLR+ AE
Sbjct: 851 VWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAE 910
Query: 910 VEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDR----------- 958
VEVVEMH SDISAYTYE+TL+MEQRSQ+L+QM LTK ERERE Q + D
Sbjct: 911 VEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPA 970
Query: 959 HSALRL---ESLYSDEED------------------------------ESAVGADKIQMT 985
++ LRL E D E+ E +K+ +T
Sbjct: 971 NTRLRLNVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLT 1030
Query: 986 WTRDKYMTE-TWDPSH-APDNFRELVHIKPD-----QSNVRRMHTAVKLNEVIVTRSHDA 1038
WT+DK + E PS + + ++ +KP+ QSNVRRMHTAV+LNEVIV +S DA
Sbjct: 1031 WTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDA 1090
Query: 1039 RLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1087
+LVLLNMPGPPRN GDENYMEFLEVLTE L+RV+LVRGGGREVITIYS
Sbjct: 1091 KLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS 1139
>gi|11968148 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 2 [Homo sapiens]
Length = 1116
Score = 1473 bits (3813), Expect = 0.0
Identities = 745/1069 (69%), Positives = 860/1069 (80%), Gaps = 56/1069 (5%)
Query: 73 EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ 132
EE+D P VSSLL L +YTNL QG++EHEEAE+ EG +++ +AP MGT MGVYLPCLQ
Sbjct: 50 EEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQ 109
Query: 133 NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS 192
NIFGVILFLRLTW+VG AG++++ +V ICC CT+LTAISMSAIATNGVVPAGGSY+MIS
Sbjct: 110 NIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMIS 169
Query: 193 RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN 252
RSLGPEFGGAVGLCFYLGTTFA AMYILG IEILL Y+ P AIF A + A LNN
Sbjct: 170 RSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNN 229
Query: 253 MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML 312
MRVYGT LT M VVFVGVKYVNKFA +FL CVI+SIL+IYAG IKS FDPP FP+C+L
Sbjct: 230 MRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLL 289
Query: 313 GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 372
GNRTLSR FD+CAK A NETV T+LW FC S L +CD YF NNVTEI GIPG
Sbjct: 290 GNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNA-TCDEYFTRNNVTEIQGIPG 348
Query: 373 AAAGVLQENLWSAYLEKGDIVEKHGLPS---ADAPSLKESLPLYVVADIATSFTVLVGIF 429
AA+G+++ENLWS+YL KG IVE+ G+ S AD + P YV +D+ + FT+LVGI+
Sbjct: 349 AASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHP-YVFSDMTSYFTLLVGIY 407
Query: 430 FPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYG 489
FPSVTGIMAGSNRSGDLRDAQKSIP GTILAI TTS VY SSVVLFGACIEGVVLRDK+G
Sbjct: 408 FPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFG 467
Query: 490 DGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGH 549
+ V+ NLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAI++D I+PFL+VFGH
Sbjct: 468 EAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGH 527
Query: 550 GKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNW 609
GK NGEPTWALLLTA I E+GILIASLD VAPILSMFFLMCY+FVNLACAVQTLLRTPNW
Sbjct: 528 GKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNW 587
Query: 610 RPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRG 669
RPRF+YYHW LSFLGMSLCLALMF+ SWYYALVAMLIAG+IYKYIEY+GAEKEWGDGIRG
Sbjct: 588 RPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRG 647
Query: 670 LSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIV 729
LSLSAARYALLRLEEGPPHTKNWRPQLLVL+++D+D +V +P+LL+ SQLKAGKGLTIV
Sbjct: 648 LSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIV 707
Query: 730 GSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMR 789
GSV++G+FLE++ +AQ AE++I+ +ME EKVKGFCQVV++S +R+G++HLIQS GLGG++
Sbjct: 708 GSVLEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQ 767
Query: 790 HNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHID 849
HN+V++GWP WRQ ED + W+ FI+ VR TTA HLALLV KN++ +P N ER+ EG ID
Sbjct: 768 HNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSID 827
Query: 850 VWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAE 909
VWWIVHDGGMLMLLPFLLR HKVWRKC+MRIFTVAQMDDNSIQMKKDL FLYHLR+ AE
Sbjct: 828 VWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAE 887
Query: 910 VEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDR----------- 958
VEVVEMH SDISAYTYE+TL+MEQRSQ+L+QM LTK ERERE Q + D
Sbjct: 888 VEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPA 947
Query: 959 HSALRL---ESLYSDEED------------------------------ESAVGADKIQMT 985
++ LRL E D E+ E +K+ +T
Sbjct: 948 NTRLRLNVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLT 1007
Query: 986 WTRDKYMTE-TWDPSH-APDNFRELVHIKPD-----QSNVRRMHTAVKLNEVIVTRSHDA 1038
WT+DK + E PS + + ++ +KP+ QSNVRRMHTAV+LNEVIV +S DA
Sbjct: 1008 WTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDA 1067
Query: 1039 RLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1087
+LVLLNMPGPPRN GDENYMEFLEVLTE L+RV+LVRGGGREVITIYS
Sbjct: 1068 KLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS 1116
>gi|31881740 solute carrier family 12 (potassium/chloride
transporters), member 9 [Homo sapiens]
Length = 914
Score = 264 bits (674), Expect = 4e-70
Identities = 251/868 (28%), Positives = 391/868 (45%), Gaps = 167/868 (19%)
Query: 115 AEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMS 174
A A + T +GV +P + ++F +++FLR+ ++VG AG+LQAL ++L+ LT +S+
Sbjct: 32 ASARKLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVC 91
Query: 175 AIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPA 234
AIATNG V GG+YFMISR+LGPE GG++GL FYL + G LL +
Sbjct: 92 AIATNGAVQGGGAYFMISRTLGPEVGGSIGLMFYLAN-------VCGCAVSLLGLVESVL 144
Query: 235 AIFYPSGAHDTSNATLNNM-RVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSI 293
+F GA T + L + + YG L + SL L V
Sbjct: 145 DVF---GADATGPSGLRVLPQGYGWNLL----------------YGSLLLGLV------- 178
Query: 294 YAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTD 353
GG VC LG +R F T ++ + ++A+ L SF P
Sbjct: 179 --GG-----------VCTLGAGLYARASF----LTFLLVSGSLASVLISFVAVGPRDIRL 221
Query: 354 SCDPYFMLNNVTEIPG----IPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKES 409
+ P N + +P G + L++NL + Y E
Sbjct: 222 TPRPG---PNGSSLPPRFGHFTGFNSSTLKDNLGAGYAE--------------------D 258
Query: 410 LPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYF 469
V + A+ F VL F TGIMAG+N SG+L+D ++IP+GTI+A+ T VY
Sbjct: 259 YTTGAVMNFASVFAVL----FNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYV 314
Query: 470 SSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAP 529
L + +L++ YG + +L WP +++IG + + A + SL GA
Sbjct: 315 LLFFLSSFTCDRTLLQEDYGFFRAISL------WPP--LVLIGIYATALSASMSSLIGAS 366
Query: 530 RLLQAIAKDNIIPFLRVFGHGKV---NGEPTWALLLTALIAELGILIASLDMVAPILSMF 586
R+L A+A+D++ F + KV G P A+L + + +L +L L+ +A ++++F
Sbjct: 367 RILHALARDDL--FGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVF 424
Query: 587 FLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLI 646
+L+ Y V+L+C PN+RP F + W LG++ CL +MF+ S A ++L+
Sbjct: 425 YLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLL 484
Query: 647 AGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDL 706
G++ + +G WG + L R LLRL+ H K WRPQLL+L
Sbjct: 485 MGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLL------- 537
Query: 707 HVKYPR----LLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ--TIKNMMEIEKV 760
V PR LL A+QLK G GL ++G V G L+S Q ++++ +V
Sbjct: 538 -VGNPRGALPLLRLANQLKKG-GLYVLGHVTLGD-LDSLPSDPVQPQYGAWLSLVDRAQV 594
Query: 761 KGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGW----PYGWRQSEDPRAWKTFIDT 816
K F + ++ VR+G HL++ GLGGM+ N++VLG+ P DP A+ D+
Sbjct: 595 KAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGFYDDAPPQDHFLTDP-AFSEPADS 653
Query: 817 VRCTTAAHLALLVP---------------------------KNIAFYPSN----HERYLE 845
R ++ L+ L P KN+ ++ ER
Sbjct: 654 TREGSSPALSTLFPPPRAPGSPRALNPQDYVATVADALKMNKNVVLARASGALPPERLSR 713
Query: 846 G--------HIDVW------------WIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQ 885
G H+DVW ++ G L+ + +L W R+RIF
Sbjct: 714 GSGGTSQLHHVDVWPLNLLRPRGGPGYVDVCGLFLLQMATILGMVPAWHSARLRIFLCLG 773
Query: 886 MDDNSIQMKKDLAVFLYHLRLEAEVEVV 913
+ + L L LR+ AEV+ V
Sbjct: 774 PREAPGAAEGRLRALLSQLRIRAEVQEV 801
>gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo
sapiens]
Length = 1021
Score = 234 bits (597), Expect = 3e-61
Identities = 195/739 (26%), Positives = 314/739 (42%), Gaps = 131/739 (17%)
Query: 421 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACI- 479
+F + IFFPS TGI+AG+N SGDL+D +IP GT++AI T++ Y + G+C+
Sbjct: 339 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVV 398
Query: 480 --EGVVLRDKY--GDGVSRNLVVG-----------------------TLAWPSPW--VIV 510
VL D G G L T++ S + +I
Sbjct: 399 RDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLIT 458
Query: 511 IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK-VNGEPTWALLLTALIAEL 569
G F +T + L L A ++ Q + +D + P + FG G N EP LL IA
Sbjct: 459 AGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVA 518
Query: 570 GILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCL 629
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G + +
Sbjct: 519 FIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISV 578
Query: 630 ALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHT 689
+MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 579 VIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHI 638
Query: 690 KNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 749
KN+RPQ LVL P L+ F L I G V+ G + E Q
Sbjct: 639 KNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIAN 694
Query: 750 TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRA 809
+ K+K F V+A +R G+ L+Q+ GLG M+ N +V+G+ W QS P
Sbjct: 695 GHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPAT 753
Query: 810 WKTFIDTVR---------CTTAAHLALLVPK------NIAFYPSNHERYLEGH------- 847
+ +I + C L V K N F P+ +
Sbjct: 754 VEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARVDPKALV 813
Query: 848 -----------------IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNS 890
ID++W+ DGG+ +L+P+LL + + W KC++R+F Q+ +
Sbjct: 814 KEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQI-NRM 872
Query: 891 IQMKKDLAVFLYHLRLE-AEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTERE 949
Q +K + L RL EV ++ + + R
Sbjct: 873 DQERKAIISLLSKFRLGFHEVHILP---------------------------DINQNPRA 905
Query: 950 REAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTW-TRDKYMTETWDPSHAPDNFREL 1008
+ +D + RL + +DE+ V + W D+ +T+
Sbjct: 906 EHTKRFEDMIAPFRLNDGF---KDEATVNEMRRDCPWKISDEEITK-------------- 948
Query: 1009 VHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEG 1068
N + V+LNE+++ S DA L+++ +P + YM +LE L++
Sbjct: 949 --------NRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQD 1000
Query: 1069 LE-RVLLVRGGGREVITIY 1086
L V+L+RG V+T Y
Sbjct: 1001 LRPPVILIRGNQENVLTFY 1019
Score = 125 bits (315), Expect = 2e-28
Identities = 69/198 (34%), Positives = 111/198 (56%), Gaps = 17/198 (8%)
Query: 103 EAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC 162
E E+G + + E G + GV + C+ NI+GVIL+LRL W+ AG++ +I+L+
Sbjct: 119 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 178
Query: 163 CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGA 222
T +T +S+SAI+TNG V +GG+YF+ISRSLGPE GG++GL F AM+ +G
Sbjct: 179 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 238
Query: 223 IE----ILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKF 278
E +L Y AP I P +N++R+ G + +T + + G+++ +K
Sbjct: 239 AETVRDLLQEYGAP---IVDP----------INDIRIIGVVSVTVLLAISLAGMEWESKA 285
Query: 279 ASLFLACVIISILSIYAG 296
LF +++S + G
Sbjct: 286 QVLFFLVIMVSFANYLVG 303
>gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo
sapiens]
Length = 1029
Score = 231 bits (588), Expect = 4e-60
Identities = 195/748 (26%), Positives = 314/748 (41%), Gaps = 140/748 (18%)
Query: 421 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACI- 479
+F + IFFPS TGI+AG+N SGDL+D +IP GT++AI T++ Y + G+C+
Sbjct: 338 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVV 397
Query: 480 --EGVVLRDKY--GDGVSRNLVVG-----------------------TLAWPSPW--VIV 510
VL D G G L T++ S + +I
Sbjct: 398 RDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLIT 457
Query: 511 IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK-VNGEPTWALLLTALIAEL 569
G F +T + L L A ++ Q + +D + P + FG G N EP LL IA
Sbjct: 458 AGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVA 517
Query: 570 GILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCL 629
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G + +
Sbjct: 518 FIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISV 577
Query: 630 ALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHT 689
+MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 578 VIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHI 637
Query: 690 KNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 749
KN+RPQ LVL P L+ F L I G V+ G + E Q
Sbjct: 638 KNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIAN 693
Query: 750 TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRA 809
+ K+K F V+A +R G+ L+Q+ GLG M+ N +V+G+ W QS P
Sbjct: 694 GHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPAT 752
Query: 810 WKTFIDTVR---------CTTAAHLALLVPK------NIAFYPSNHERYLEGH------- 847
+ +I + C L V K N F P+ +
Sbjct: 753 VEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSVS 812
Query: 848 --------------------------IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF 881
ID++W+ DGG+ +L+P+LL + + W KC++R+F
Sbjct: 813 GALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVF 872
Query: 882 TVAQMDDNSIQMKKDLAVFLYHLRLE-AEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQ 940
Q+ + Q +K + L RL EV ++
Sbjct: 873 VGGQI-NRMDQERKAIISLLSKFRLGFHEVHILP-------------------------- 905
Query: 941 MRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTW-TRDKYMTETWDPS 999
+ + R + +D + RL + +DE+ V + W D+ +T+
Sbjct: 906 -DINQNPRAEHTKRFEDMIAPFRLNDGF---KDEATVNEMRRDCPWKISDEEITK----- 956
Query: 1000 HAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYM 1059
N + V+LNE+++ S DA L+++ +P + YM
Sbjct: 957 -----------------NRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYM 999
Query: 1060 EFLEVLTEGLE-RVLLVRGGGREVITIY 1086
+LE L++ L V+L+RG V+T Y
Sbjct: 1000 AWLETLSQDLRPPVILIRGNQENVLTFY 1027
Score = 125 bits (315), Expect = 2e-28
Identities = 69/198 (34%), Positives = 111/198 (56%), Gaps = 17/198 (8%)
Query: 103 EAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC 162
E E+G + + E G + GV + C+ NI+GVIL+LRL W+ AG++ +I+L+
Sbjct: 118 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 177
Query: 163 CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGA 222
T +T +S+SAI+TNG V +GG+YF+ISRSLGPE GG++GL F AM+ +G
Sbjct: 178 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 237
Query: 223 IE----ILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKF 278
E +L Y AP I P +N++R+ G + +T + + G+++ +K
Sbjct: 238 AETVRDLLQEYGAP---IVDP----------INDIRIIGVVSVTVLLAISLAGMEWESKA 284
Query: 279 ASLFLACVIISILSIYAG 296
LF +++S + G
Sbjct: 285 QVLFFLVIMVSFANYLVG 302
>gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo
sapiens]
Length = 1030
Score = 231 bits (588), Expect = 4e-60
Identities = 195/748 (26%), Positives = 314/748 (41%), Gaps = 140/748 (18%)
Query: 421 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACI- 479
+F + IFFPS TGI+AG+N SGDL+D +IP GT++AI T++ Y + G+C+
Sbjct: 339 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVV 398
Query: 480 --EGVVLRDKY--GDGVSRNLVVG-----------------------TLAWPSPW--VIV 510
VL D G G L T++ S + +I
Sbjct: 399 RDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLIT 458
Query: 511 IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK-VNGEPTWALLLTALIAEL 569
G F +T + L L A ++ Q + +D + P + FG G N EP LL IA
Sbjct: 459 AGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVA 518
Query: 570 GILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCL 629
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G + +
Sbjct: 519 FIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISV 578
Query: 630 ALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHT 689
+MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 579 VIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHI 638
Query: 690 KNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 749
KN+RPQ LVL P L+ F L I G V+ G + E Q
Sbjct: 639 KNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIAN 694
Query: 750 TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRA 809
+ K+K F V+A +R G+ L+Q+ GLG M+ N +V+G+ W QS P
Sbjct: 695 GHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPAT 753
Query: 810 WKTFIDTVR---------CTTAAHLALLVPK------NIAFYPSNHERYLEGH------- 847
+ +I + C L V K N F P+ +
Sbjct: 754 VEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSVS 813
Query: 848 --------------------------IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF 881
ID++W+ DGG+ +L+P+LL + + W KC++R+F
Sbjct: 814 GALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVF 873
Query: 882 TVAQMDDNSIQMKKDLAVFLYHLRLE-AEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQ 940
Q+ + Q +K + L RL EV ++
Sbjct: 874 VGGQI-NRMDQERKAIISLLSKFRLGFHEVHILP-------------------------- 906
Query: 941 MRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTW-TRDKYMTETWDPS 999
+ + R + +D + RL + +DE+ V + W D+ +T+
Sbjct: 907 -DINQNPRAEHTKRFEDMIAPFRLNDGF---KDEATVNEMRRDCPWKISDEEITK----- 957
Query: 1000 HAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYM 1059
N + V+LNE+++ S DA L+++ +P + YM
Sbjct: 958 -----------------NRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYM 1000
Query: 1060 EFLEVLTEGLE-RVLLVRGGGREVITIY 1086
+LE L++ L V+L+RG V+T Y
Sbjct: 1001 AWLETLSQDLRPPVILIRGNQENVLTFY 1028
Score = 125 bits (315), Expect = 2e-28
Identities = 69/198 (34%), Positives = 111/198 (56%), Gaps = 17/198 (8%)
Query: 103 EAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC 162
E E+G + + E G + GV + C+ NI+GVIL+LRL W+ AG++ +I+L+
Sbjct: 119 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 178
Query: 163 CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGA 222
T +T +S+SAI+TNG V +GG+YF+ISRSLGPE GG++GL F AM+ +G
Sbjct: 179 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 238
Query: 223 IE----ILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKF 278
E +L Y AP I P +N++R+ G + +T + + G+++ +K
Sbjct: 239 AETVRDLLQEYGAP---IVDP----------INDIRIIGVVSVTVLLAISLAGMEWESKA 285
Query: 279 ASLFLACVIISILSIYAG 296
LF +++S + G
Sbjct: 286 QVLFFLVIMVSFANYLVG 303
>gi|4506975 solute carrier family 12 (sodium/potassium/chloride
transporters), member 2 [Homo sapiens]
Length = 1212
Score = 231 bits (588), Expect = 4e-60
Identities = 148/420 (35%), Positives = 214/420 (50%), Gaps = 44/420 (10%)
Query: 421 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE 480
+F + IFFP+ TGI+AG+N SGDL D Q +IP GT+LAI+ T+LVY V G+C
Sbjct: 486 TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSC-- 543
Query: 481 GVVLRDKYGD---------------------------------GVSRNLVVGTLAWPSPW 507
V+RD G+ G+ N V ++
Sbjct: 544 --VVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTP 601
Query: 508 VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHGKVNGEPTWALLLTAL 565
+I G F +T + L SL AP++ QA+ KDNI P ++F G+GK N EP +LT L
Sbjct: 602 LISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGK-NNEPLRGYILTFL 660
Query: 566 IAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGM 625
IA ILIA L+++API+S FFL Y +N + +L ++P WRP FKYY+ +S LG
Sbjct: 661 IALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGA 720
Query: 626 SLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEG 685
LC +MFV +W+ AL+ +I +Y Y+ Y+ + WG + L+ A +RL
Sbjct: 721 ILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGV 780
Query: 686 PPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQ 745
H KN+RPQ LV+ P LL GL I G V G ++ E
Sbjct: 781 EDHVKNFRPQCLVMTGAPN----SRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMS 836
Query: 746 AAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSE 805
+ + + K+K F V A +REG +L+Q+ GLG M+ N++VLG+ W Q++
Sbjct: 837 IDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQAD 896
Score = 124 bits (310), Expect = 6e-28
Identities = 69/217 (31%), Positives = 120/217 (55%), Gaps = 12/217 (5%)
Query: 77 IRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSM---GTLMGVYLPCLQN 133
+RP ++ L +L A E + + AE+ + G + GV + C+ N
Sbjct: 239 LRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLN 298
Query: 134 IFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISR 193
I+GV+LF+RL+W+VG AG+ ++L++++ T +T +S SAIATNG V GG+Y++ISR
Sbjct: 299 IWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLISR 358
Query: 194 SLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNM 253
SLGPEFGGA+GL F A AMY++G E ++ + + + +N++
Sbjct: 359 SLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDE---------INDI 409
Query: 254 RVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISI 290
R+ G I + + + G+++ K + L ++++I
Sbjct: 410 RIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAI 446
Score = 74.3 bits (181), Expect = 6e-13
Identities = 58/242 (23%), Positives = 113/242 (46%), Gaps = 55/242 (22%)
Query: 848 IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQM-KKDLAVFLYHLRL 906
IDVWW+ DGG+ +L+P+LL K W+ C++R+F ++ N I ++ +A L R+
Sbjct: 1024 IDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKI--NRIDHDRRAMATLLSKFRI 1081
Query: 907 E-AEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLE 965
+ +++ V+ DI+ + ++ + +++ RL + ++E++
Sbjct: 1082 DFSDIMVL----GDINTKPKKENIIAFE--EIIEPYRLHEDDKEQDI------------- 1122
Query: 966 SLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAV 1025
ADK++ +P DN EL K + +
Sbjct: 1123 -------------ADKMKED-----------EPWRITDNELELYKTK--------TYRQI 1150
Query: 1026 KLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITI 1085
+LNE++ S A ++++++P + + YM +LE L++ L +LLVRG + V+T
Sbjct: 1151 RLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSVLTF 1210
Query: 1086 YS 1087
YS
Sbjct: 1211 YS 1212
>gi|134254459 sodium potassium chloride cotransporter 2 [Homo
sapiens]
Length = 1099
Score = 212 bits (540), Expect = 1e-54
Identities = 139/418 (33%), Positives = 203/418 (48%), Gaps = 44/418 (10%)
Query: 422 FTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEG 481
F + IFFP+ TGI+AG+N SGDL D Q +IP GT+LAI T++ Y + GAC
Sbjct: 380 FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGAC--- 436
Query: 482 VVLRDKYGD---------------------------------GVSRNLVVGTLAWPSPWV 508
V+RD G+ G+ N V ++ +
Sbjct: 437 -VVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPL 495
Query: 509 IVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHGKVNGEPTWALLLTALI 566
I G F +T + L SL AP++ QA+ KDNI L+ F G+GK N EP +LT LI
Sbjct: 496 ITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGK-NNEPLRGYILTFLI 554
Query: 567 AELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMS 626
A ILIA L+ +API+S FFL Y +N +C + ++P WRP + Y+ +S G
Sbjct: 555 AMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAV 614
Query: 627 LCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGP 686
LC A+MFV +W+ A++ +I +Y Y+ + + WG + LS +A L L
Sbjct: 615 LCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVE 674
Query: 687 PHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQA 746
H KN+RPQ +VL + P LL GL I V G E +
Sbjct: 675 DHVKNFRPQCIVL----TGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNS 730
Query: 747 AEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQS 804
+ + K+K F V A R+G+ L+Q+ GLG M+ N++V+G+ WR++
Sbjct: 731 GMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKA 788
Score = 127 bits (320), Expect = 4e-29
Identities = 70/202 (34%), Positives = 116/202 (57%), Gaps = 12/202 (5%)
Query: 97 GAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQAL 156
G E+AE+ E + A G + GV + C+ NI+GV+LF+RL+W+VG AG+ +
Sbjct: 157 GIPGDEQAENKEDDQ---AGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGV 213
Query: 157 LIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAA 216
LI+L+ T +T +S SAIATNG V GG+Y++ISRSLGPEFGG++GL F A A
Sbjct: 214 LIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVA 273
Query: 217 MYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVN 276
MY++G E ++ + ++ N++R+ G+I + + + G+++
Sbjct: 274 MYVVGFAETVVDLLKESDSMMVD---------PTNDIRIIGSITVVILLGISVAGMEWEA 324
Query: 277 KFASLFLACVIISILSIYAGGI 298
K + L ++I+I + + G +
Sbjct: 325 KAQVILLVILLIAIANFFIGTV 346
Score = 79.3 bits (194), Expect = 2e-14
Identities = 66/246 (26%), Positives = 117/246 (47%), Gaps = 57/246 (23%)
Query: 845 EGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKD-LAVFLYH 903
+G IDVWW+ DGG+ +L+P++L K W+ C++RI+ ++ N I+ +K +A L
Sbjct: 908 KGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKI--NRIEEEKIVMASLLSK 965
Query: 904 LRLE-AEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSAL 962
R++ A++ ++ DI+ + + + + +M+ RL ++ ++
Sbjct: 966 FRIKFADIHII----GDINIRPNKESWKVFE--EMIEPYRLHESCKDLT----------- 1008
Query: 963 RLESLYSDEEDESAVGADKIQMTWTRDKYMTET-WDPSHAPDNFRELVHIKPDQSNVRRM 1021
T +K ET W + A EL +K +
Sbjct: 1009 ------------------------TAEKLKRETPWKITDA-----ELEAVK------EKS 1033
Query: 1022 HTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGRE 1081
+ V+LNE++ S A L++L++P + S D YM +LE+LT+ L VLLVRG +
Sbjct: 1034 YRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKN 1093
Query: 1082 VITIYS 1087
V+T YS
Sbjct: 1094 VLTFYS 1099
>gi|38569457 solute carrier family 12, member 8 [Homo sapiens]
Length = 714
Score = 102 bits (253), Expect = 3e-21
Identities = 57/176 (32%), Positives = 99/176 (56%), Gaps = 9/176 (5%)
Query: 421 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE 480
SF + G+FFP+ TG+MAG N GDLR+ SIP+G++ A+ + +Y V L GA
Sbjct: 232 SFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICT 291
Query: 481 GVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNI 540
LR + ++ ++ ++G + S+ + + L GAPR+LQ IA++ +
Sbjct: 292 REALR--------YDFLIAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKV 343
Query: 541 IPFLRVFGHGK-VNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVN 595
IP L G GK N P A+ LT+L+ + + ++++API+++ F++ Y+ V+
Sbjct: 344 IPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVD 399
Score = 86.7 bits (213), Expect = 1e-16
Identities = 44/104 (42%), Positives = 58/104 (55%)
Query: 121 GTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNG 180
GT GV+ C+ NIFGV+LFLR W+VG GVL + +V L+T +S +
Sbjct: 40 GTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERS 99
Query: 181 VVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIE 224
+ +GG Y MIS LG + GG +GL + G A AMYI G E
Sbjct: 100 SIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAE 143
Score = 34.3 bits (77), Expect = 0.66
Identities = 20/51 (39%), Positives = 26/51 (50%), Gaps = 6/51 (11%)
Query: 609 WRPRFKYYH-----WALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYI 654
WR +Y W +S LG L +MFV W Y LV M +A ++Y YI
Sbjct: 582 WRRSTSFYTHMCNPW-VSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYI 631
>gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo
sapiens]
Length = 697
Score = 50.8 bits (120), Expect = 7e-06
Identities = 47/187 (25%), Positives = 82/187 (43%), Gaps = 16/187 (8%)
Query: 415 VADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVL 474
+A AT F VG + TG ++R+ QK+IP+G + +++ + YF
Sbjct: 298 LAGAATCFYAFVGFDCIATTG--------EEVRNPQKAIPIGIVTSLLVCFMAYFGVSAA 349
Query: 475 FGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQ 533
+ +L +K V+ V W P+ +V+ GS + + L S+ PR+L
Sbjct: 350 LTLMMPYYLLDEKSPLPVAFEYV----GWGPAKYVVAAGSLCALSTSLLGSMFPLPRILF 405
Query: 534 AIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLF 593
A+A+D ++ R P A L +I+ L + L + ++S+ LM Y
Sbjct: 406 AMARDGLL--FRFLARVSKRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSL 463
Query: 594 VNLACAV 600
V AC +
Sbjct: 464 V-AACVL 469
>gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo
sapiens]
Length = 658
Score = 47.4 bits (111), Expect = 8e-05
Identities = 46/187 (24%), Positives = 83/187 (44%), Gaps = 15/187 (8%)
Query: 415 VADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVL 474
+A AT F VG + TG ++R+ QK+IP+G + +++ + YF
Sbjct: 258 LAGAATCFYAFVGFDCIATTG--------EEVRNPQKAIPIGIVTSLLVCFMAYFGVSAA 309
Query: 475 FGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQ 533
+ +L +K V+ V W P+ +V+ GS + + L S+ PR++
Sbjct: 310 LTLMMPYYLLDEKSPLPVAFEYV----GWGPAKYVVAAGSLCALSTSLLGSIFPMPRVIY 365
Query: 534 AIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLF 593
A+A+D ++ F + P A L + +A L + L + ++S+ LM Y
Sbjct: 366 AMAEDGLL-FKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTLMAYSL 424
Query: 594 VNLACAV 600
V AC +
Sbjct: 425 V-AACVL 430
>gi|114326550 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 3 [Homo sapiens]
Length = 619
Score = 39.3 bits (90), Expect = 0.020
Identities = 42/189 (22%), Positives = 84/189 (44%), Gaps = 16/189 (8%)
Query: 414 VVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVV 473
++ AT F VG + TG A ++ Q+SIP+G ++++ L YF+
Sbjct: 253 ILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSIPMGIVISLSVCFLAYFAVSS 304
Query: 474 LFGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLL 532
+ L+ + L +G W P+ +V+ +GS + + L S+ PR++
Sbjct: 305 ALTLMMPYYQLQPE-SPLPEAFLYIG---WAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360
Query: 533 QAIAKDNIIPFLRVFGHGKVNGE-PTWALLLTALIAELGILIASLDMVAPILSMFFLMCY 591
A+A+D ++ RV P A +++ +IA + L + ++S+ L+ Y
Sbjct: 361 YAMAEDGLL--FRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAY 418
Query: 592 LFVNLACAV 600
V++ +
Sbjct: 419 SLVSICVLI 427
>gi|114326544 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 3 [Homo sapiens]
Length = 619
Score = 39.3 bits (90), Expect = 0.020
Identities = 42/189 (22%), Positives = 84/189 (44%), Gaps = 16/189 (8%)
Query: 414 VVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVV 473
++ AT F VG + TG A ++ Q+SIP+G ++++ L YF+
Sbjct: 253 ILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSIPMGIVISLSVCFLAYFAVSS 304
Query: 474 LFGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLL 532
+ L+ + L +G W P+ +V+ +GS + + L S+ PR++
Sbjct: 305 ALTLMMPYYQLQPE-SPLPEAFLYIG---WAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360
Query: 533 QAIAKDNIIPFLRVFGHGKVNGE-PTWALLLTALIAELGILIASLDMVAPILSMFFLMCY 591
A+A+D ++ RV P A +++ +IA + L + ++S+ L+ Y
Sbjct: 361 YAMAEDGLL--FRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAY 418
Query: 592 LFVNLACAV 600
V++ +
Sbjct: 419 SLVSICVLI 427
>gi|4507047 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 1 [Homo sapiens]
Length = 629
Score = 38.1 bits (87), Expect = 0.046
Identities = 44/209 (21%), Positives = 91/209 (43%), Gaps = 29/209 (13%)
Query: 414 VVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFS--- 470
V++ AT F VG + TG ++++ QK+IPVG + +++ + YF
Sbjct: 255 VLSGAATCFYAFVGFDCIATTG--------EEVKNPQKAIPVGIVASLLICFIAYFGVSA 306
Query: 471 --SVVLFGACIE-GVVLRDKYGDGVSRNLVVGTLAWP-SPWVIVIGSFFSTCGAGLQSLT 526
++++ C++ L D + + W + + + +GS + + L S+
Sbjct: 307 ALTLMMPYFCLDNNSPLPDAFKH----------VGWEGAKYAVAVGSLCALSASLLGSMF 356
Query: 527 GAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMF 586
PR++ A+A+D ++ F + P A L + +A + + L + ++S+
Sbjct: 357 PMPRVIYAMAEDGLL-FKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIG 415
Query: 587 FLMCYLFVNLACAVQTLLRTPNWRPRFKY 615
L+ Y +L A +LR +P Y
Sbjct: 416 TLLAY---SLVAACVLVLRYQPEQPNLVY 441
>gi|181337167 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 14 [Homo sapiens]
Length = 771
Score = 36.2 bits (82), Expect = 0.17
Identities = 40/184 (21%), Positives = 75/184 (40%), Gaps = 14/184 (7%)
Query: 414 VVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVV 473
V+ AT F +G + TG A ++ SIP +++ Y S V
Sbjct: 254 VLQGAATCFYAFIGFDIIATTGEEA--------KNPNTSIPYAITASLVICLTAYVSVSV 305
Query: 474 LFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQ 533
+ + + + + V + + +V+ IGS + L SL PR++
Sbjct: 306 ILTLMVPYYTIDT---ESPLMEMFVAHGFYAAKFVVAIGSVAGLTVSLLGSLFPMPRVIY 362
Query: 534 AIAKDNIIPFLRVFGH-GKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYL 592
A+A D ++ R H P A +++ +A L L+ SL + ++S+ L+ Y
Sbjct: 363 AMAGDGLL--FRFLAHVSSYTETPVVACIVSGFLAALLALLVSLRDLIEMMSIGTLLAYT 420
Query: 593 FVNL 596
V++
Sbjct: 421 LVSV 424
>gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]
Length = 1115
Score = 35.8 bits (81), Expect = 0.23
Identities = 47/181 (25%), Positives = 77/181 (42%), Gaps = 35/181 (19%)
Query: 125 GVYLPCLQNIFGVILFLRL------TWMVGT-AGVLQALLIVLICC----CCTL----LT 169
G Y+ C +F I F++L T M+G A + LLI ++ C C +L L
Sbjct: 670 GAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQ 729
Query: 170 AISMSAIATNGVVPAGGSYFMI----SRSLGPEFGGAVGLCFYLGTTFA--------AAM 217
+S S + + A G + ++ S F G + L + F A +
Sbjct: 730 RLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMYFIGNMLLSLLASSVFLHISSIGKLAMI 789
Query: 218 YILGAIEILLTYIAPPAAIF----YPSGAHD--TSNATLNNM--RVYGTIFLTFMTLVVF 269
++LG I ++L + PPA IF G H +SN T + + G + L +MT V+
Sbjct: 790 FVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVIL 849
Query: 270 V 270
+
Sbjct: 850 L 850
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 35.4 bits (80), Expect = 0.30
Identities = 39/188 (20%), Positives = 83/188 (44%), Gaps = 26/188 (13%)
Query: 877 RMRIFTVAQMDDNSIQ----MKKDLAVFLYHLRLEAEVEV---VEMHNSDISAYTYERTL 929
R RI + + S+Q KDLAV L + + E+ VE H +++ + +++
Sbjct: 566 RTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDA 625
Query: 930 MMEQRSQMLRQMRLTKTERERE------AQLVKDRHSALR----------LESLYSDEED 973
+ ++ Q+L+Q T+ E+ RE L+KD+ + LE L + +
Sbjct: 626 LWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTE 685
Query: 974 ESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQS---NVRRMHTAVKLNEV 1030
++ ++ ++ R K E D ++ + K D+ + +++ + +K +EV
Sbjct: 686 LESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEV 745
Query: 1031 IVTRSHDA 1038
+ R+ A
Sbjct: 746 SIQRTEKA 753
>gi|4758646 kinesin family member 3B [Homo sapiens]
Length = 747
Score = 34.7 bits (78), Expect = 0.50
Identities = 24/123 (19%), Positives = 59/123 (47%), Gaps = 3/123 (2%)
Query: 866 LLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTY 925
++ H + + +MR+ + ++ +KD A L +++A + + +I +T
Sbjct: 428 IVEDHSLVAEEKMRLLKEKEKKMEDLRREKDAAEML-GAKIKAMESKLLVGGKNIVDHTN 486
Query: 926 ERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMT 985
E+ ++EQ+ Q + + + + ERE + Q+ L L+ YS + E + K++
Sbjct: 487 EQQKILEQKRQEIAEQK--RREREIQQQMESRDEETLELKETYSSLQQEVDIKTKKLKKL 544
Query: 986 WTR 988
+++
Sbjct: 545 FSK 547
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,985,874
Number of Sequences: 37866
Number of extensions: 1768060
Number of successful extensions: 6369
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 46
Number of HSP's that attempted gapping in prelim test: 6200
Number of HSP's gapped (non-prelim): 167
length of query: 1087
length of database: 18,247,518
effective HSP length: 113
effective length of query: 974
effective length of database: 13,968,660
effective search space: 13605474840
effective search space used: 13605474840
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.