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Search of human proteins with 115430252
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|115430252 serine threonine kinase 39 (STE20/SPS1 homolog,
yeast) [Homo sapiens]
(545 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|115430252 serine threonine kinase 39 (STE20/SPS1 homolog, yea... 1082 0.0
gi|4826878 oxidative-stress responsive 1 [Homo sapiens] 761 0.0
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 237 2e-62
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 237 2e-62
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 234 2e-61
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 228 1e-59
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 202 8e-52
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 197 3e-50
gi|109633028 serine/threonine protein kinase MST4 isoform 2 [Hom... 192 9e-49
gi|145275208 myosin IIIA [Homo sapiens] 189 4e-48
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens] 186 6e-47
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 185 8e-47
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens] 185 8e-47
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens] 185 8e-47
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens] 185 8e-47
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens] 185 8e-47
gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens] 185 8e-47
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 184 1e-46
gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens] 183 4e-46
gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens] 183 4e-46
gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens] 183 4e-46
gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens] 183 4e-46
gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens] 183 4e-46
gi|32483399 p21-activated kinase 2 [Homo sapiens] 182 9e-46
gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens] 182 9e-46
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 181 1e-45
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 181 1e-45
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 181 1e-45
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 181 1e-45
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 181 1e-45
>gi|115430252 serine threonine kinase 39 (STE20/SPS1 homolog, yeast)
[Homo sapiens]
Length = 545
Score = 1082 bits (2799), Expect = 0.0
Identities = 545/545 (100%), Positives = 545/545 (100%)
Query: 1 MAEPSGSPVHVQLPQQAAPVTAAAAAAPAAATAAPAPAAPAAPAPAPAPAAQAVGWPICR 60
MAEPSGSPVHVQLPQQAAPVTAAAAAAPAAATAAPAPAAPAAPAPAPAPAAQAVGWPICR
Sbjct: 1 MAEPSGSPVHVQLPQQAAPVTAAAAAAPAAATAAPAPAAPAAPAPAPAPAAQAVGWPICR 60
Query: 61 DAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPN 120
DAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPN
Sbjct: 61 DAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPN 120
Query: 121 VVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGL 180
VVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGL
Sbjct: 121 VVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGL 180
Query: 181 DYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMA 240
DYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMA
Sbjct: 181 DYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMA 240
Query: 241 PEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDK 300
PEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDK
Sbjct: 241 PEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDK 300
Query: 301 EMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQR 360
EMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQR
Sbjct: 301 EMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQR 360
Query: 361 AKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKEENPEIAVSAS 420
AKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKEENPEIAVSAS
Sbjct: 361 AKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKEENPEIAVSAS 420
Query: 421 TIPEQIQSLSVHDSQGPPNANEDYREASSCAVNLVLRLRNSRKELNDIRFEFTPGRDTAD 480
TIPEQIQSLSVHDSQGPPNANEDYREASSCAVNLVLRLRNSRKELNDIRFEFTPGRDTAD
Sbjct: 421 TIPEQIQSLSVHDSQGPPNANEDYREASSCAVNLVLRLRNSRKELNDIRFEFTPGRDTAD 480
Query: 481 GVSQELFSAGLVDGHDVVIVAANLQKIVDDPKALKTLTFKLASGCDGSEIPDEVKLIGFA 540
GVSQELFSAGLVDGHDVVIVAANLQKIVDDPKALKTLTFKLASGCDGSEIPDEVKLIGFA
Sbjct: 481 GVSQELFSAGLVDGHDVVIVAANLQKIVDDPKALKTLTFKLASGCDGSEIPDEVKLIGFA 540
Query: 541 QLSVS 545
QLSVS
Sbjct: 541 QLSVS 545
>gi|4826878 oxidative-stress responsive 1 [Homo sapiens]
Length = 527
Score = 761 bits (1964), Expect = 0.0
Identities = 389/523 (74%), Positives = 446/523 (85%), Gaps = 28/523 (5%)
Query: 51 AQAVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEI 110
+ A+ W I RD YELQEVIGSGATAVVQAA C P++E+VAIKRINLEKCQTSMDELLKEI
Sbjct: 5 SSALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEI 64
Query: 111 QAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIA 170
QAMSQC HPN+V+YYTSFVVKDELWLVMKLLSGGS+LDIIK+IV +GEHK+GVL+E+ IA
Sbjct: 65 QAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIA 124
Query: 171 TILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRK 230
TIL+EVLEGL+YLH+NGQIHRD+KAGNILLGEDGSVQIADFGVSAFLATGGD+TRNKVRK
Sbjct: 125 TILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRK 184
Query: 231 TFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDP 290
TFVGTPCWMAPEVMEQVRGYDFKAD+WSFGITAIELATGAAPYHKYPPMKVLMLTLQNDP
Sbjct: 185 TFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDP 244
Query: 291 PTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKL 350
P+LETGV+DKEM+KKYGKSFRK++SLCLQKDP KRPTAAELL+ KFFQKAKN+E+L EK
Sbjct: 245 PSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKT 304
Query: 351 LTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKE 410
L R P I++RAKKVRRVPGSSG LHKTEDG WEWSDDE DE+SEEGKAA SQ +S RVKE
Sbjct: 305 LQRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSPRVKE 364
Query: 411 --ENPEIAVSAS------TIPEQIQS--------LSVHDSQG--PPNA----------NE 442
N E+ + +PEQI + ++ +Q PP A +
Sbjct: 365 SISNSELFPTTDPVGTLLQVPEQISAHLPQPAGQIATQPTQVSLPPTAEPAKTAQALSSG 424
Query: 443 DYREASSCAVNLVLRLRNSRKELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAA 502
+ + ++LVLRLRNS+KELNDIRFEFTPGRDTA+GVSQEL SAGLVDG D+VIVAA
Sbjct: 425 SGSQETKIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAA 484
Query: 503 NLQKIVDDPKALKTLTFKLASGCDGSEIPDEVKLIGFAQLSVS 545
NLQKIV++P++ +++TFKLASG +GS+IPD+ KLIGFAQLS+S
Sbjct: 485 NLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQLSIS 527
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 237 bits (605), Expect = 2e-62
Identities = 148/360 (41%), Positives = 204/360 (56%), Gaps = 42/360 (11%)
Query: 67 EVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYT 126
E IG G+ V + Q+ VAIK I+LE+ + ++++ +EI +SQC P V YY
Sbjct: 28 EKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYG 87
Query: 127 SFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRN 186
S++ +LW++M+ L GGS LD+++ G L+E IATIL+E+L+GLDYLH
Sbjct: 88 SYLKDTKLWIIMEYLGGGSALDLLE---------PGPLDETQIATILREILKGLDYLHSE 138
Query: 187 GQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKV-RKTFVGTPCWMAPEVME 245
+IHRD+KA N+LL E G V++ADFGV+ G +T ++ R TFVGTP WMAPEV++
Sbjct: 139 KKIHRDIKAANVLLSEHGEVKLADFGVA------GQLTDTQIKRNTFVGTPFWMAPEVIK 192
Query: 246 QVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKK 305
Q YD KAD+WS GITAIELA G P+ + PMKVL L +N+PPTLE
Sbjct: 193 Q-SAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLE---------GN 242
Query: 306 YGKSFRKLLSLCLQKDPSKRPTAAELLKCKF-FQKAKNREYLIEKLLTRTPDIAQRAKKV 364
Y K ++ + CL K+PS RPTA ELLK KF + AK YL E + D +R K
Sbjct: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELI-----DRYKRWKAE 297
Query: 365 RRVPGSSGHLHKTE----------DGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKEENPE 414
+ SS E GDW ++ E D K+ E A + R ++ P+
Sbjct: 298 QSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPK 357
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 237 bits (605), Expect = 2e-62
Identities = 148/360 (41%), Positives = 204/360 (56%), Gaps = 42/360 (11%)
Query: 67 EVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYT 126
E IG G+ V + Q+ VAIK I+LE+ + ++++ +EI +SQC P V YY
Sbjct: 40 EKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYG 99
Query: 127 SFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRN 186
S++ +LW++M+ L GGS LD+++ G L+E IATIL+E+L+GLDYLH
Sbjct: 100 SYLKDTKLWIIMEYLGGGSALDLLE---------PGPLDETQIATILREILKGLDYLHSE 150
Query: 187 GQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKV-RKTFVGTPCWMAPEVME 245
+IHRD+KA N+LL E G V++ADFGV+ G +T ++ R TFVGTP WMAPEV++
Sbjct: 151 KKIHRDIKAANVLLSEHGEVKLADFGVA------GQLTDTQIKRNTFVGTPFWMAPEVIK 204
Query: 246 QVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKK 305
Q YD KAD+WS GITAIELA G P+ + PMKVL L +N+PPTLE
Sbjct: 205 Q-SAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLE---------GN 254
Query: 306 YGKSFRKLLSLCLQKDPSKRPTAAELLKCKF-FQKAKNREYLIEKLLTRTPDIAQRAKKV 364
Y K ++ + CL K+PS RPTA ELLK KF + AK YL E + D +R K
Sbjct: 255 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELI-----DRYKRWKAE 309
Query: 365 RRVPGSSGHLHKTE----------DGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKEENPE 414
+ SS E GDW ++ E D K+ E A + R ++ P+
Sbjct: 310 QSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPK 369
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 234 bits (596), Expect = 2e-61
Identities = 137/330 (41%), Positives = 195/330 (59%), Gaps = 42/330 (12%)
Query: 69 IGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYTSF 128
IG G+ V + +E VAIK I+LE+ + ++++ +EI +SQC P + Y+ S+
Sbjct: 26 IGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSY 85
Query: 129 VVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQ 188
+ +LW++M+ L GGS LD++K G LEE IATIL+E+L+GLDYLH +
Sbjct: 86 LKSTKLWIIMEYLGGGSALDLLK---------PGPLEETYIATILREILKGLDYLHSERK 136
Query: 189 IHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKV-RKTFVGTPCWMAPEVMEQV 247
IHRD+KA N+LL E G V++ADFGV+ G +T ++ R TFVGTP WMAPEV++Q
Sbjct: 137 IHRDIKAANVLLSEQGDVKLADFGVA------GQLTDTQIKRNTFVGTPFWMAPEVIKQ- 189
Query: 248 RGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYG 307
YDFKAD+WS GITAIELA G P PM+VL L +N PPTLE ++
Sbjct: 190 SAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLE---------GQHS 240
Query: 308 KSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRV 367
K F++ + CL KDP RPTA ELLK KF + + + +L+ R +R K
Sbjct: 241 KPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDR----YKRWK----- 291
Query: 368 PGSSGHLHKTEDGDWEWSDDEMDEKSEEGK 397
S GH ++ D ++D ++E+G+
Sbjct: 292 --SEGHGEESSS-----EDSDIDGEAEDGE 314
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 228 bits (581), Expect = 1e-59
Identities = 147/369 (39%), Positives = 204/369 (55%), Gaps = 53/369 (14%)
Query: 67 EVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYT 126
E IG G+ V + Q+ VAIK I+LE+ + ++++ +EI +SQC V YY
Sbjct: 28 ERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYG 87
Query: 127 SFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRN 186
S++ +LW++M+ L GGS LD+++ G +E IAT+LKE+L+GLDYLH
Sbjct: 88 SYLKGSKLWIIMEYLGGGSALDLLRA---------GPFDEFQIATMLKEILKGLDYLHSE 138
Query: 187 GQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKV-RKTFVGTPCWMAPEVME 245
+IHRD+KA N+LL E G V++ADFGV+ G +T ++ R TFVGTP WMAPEV++
Sbjct: 139 KKIHRDIKAANVLLSEQGDVKLADFGVA------GQLTDTQIKRNTFVGTPFWMAPEVIQ 192
Query: 246 QVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKK 305
Q YD KAD+WS GITAIELA G P PM+VL L +N+PPTL +
Sbjct: 193 Q-SAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTL---------VGD 242
Query: 306 YGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQK-AKNREYLIEKLLTRTPDIAQRAKKV 364
+ KSF++ + CL KDPS RPTA ELLK KF K +K YL E + R K+
Sbjct: 243 FTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTE--------LIDRFKRW 294
Query: 365 RRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKEENPEIAVSASTIPE 424
+ + GH SDDE D EG + S + E V P+
Sbjct: 295 K----AEGH-----------SDDESD---SEGSDSESTSRENNTHPEWSFTTVRKKPDPK 336
Query: 425 QIQSLSVHD 433
++Q+ + D
Sbjct: 337 KVQNGAEQD 345
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 202 bits (513), Expect = 8e-52
Identities = 134/377 (35%), Positives = 196/377 (51%), Gaps = 42/377 (11%)
Query: 61 DAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPN 120
+ +++ E +G G+ V A+ K + VAIK++ +E + + E++KEI M QC P+
Sbjct: 28 EVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE---SDLQEIIKEISIMQQCDSPH 84
Query: 121 VVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGL 180
VV YY S+ +LW+VM+ GS+ DII+ +N L E IATIL+ L+GL
Sbjct: 85 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRL-------RNKTLTEDEIATILQSTLKGL 137
Query: 181 DYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMA 240
+YLH +IHRD+KAGNILL +G ++ADFGV+ L T K R T +GTP WMA
Sbjct: 138 EYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTD----TMAK-RNTVIGTPFWMA 192
Query: 241 PEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDK 300
PEV++++ GY+ AD+WS GITAIE+A G PY PM+ + + N PPT
Sbjct: 193 PEVIQEI-GYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTF------- 244
Query: 301 EMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQR 360
+ + +F + CL K P +R TA +LL+ F + AK L D+
Sbjct: 245 RKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSIL--------RDLINE 296
Query: 361 AKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKEENPEIAVSAS 420
A V+ S +D + +DEMD S R V +E + V AS
Sbjct: 297 AMDVKLKRQESQQREVDQDDEENSEEDEMD----------SGTMVRAVGDEMGTVRV-AS 345
Query: 421 TIPEQIQSLSVHDSQGP 437
T+ + ++ HD P
Sbjct: 346 TMTDGANTMIEHDDTLP 362
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 197 bits (500), Expect = 3e-50
Identities = 131/374 (35%), Positives = 197/374 (52%), Gaps = 43/374 (11%)
Query: 61 DAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPN 120
+ +++ E +G G+ V A+ K + VAIK++ +E + + E++KEI M QC P
Sbjct: 25 EVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE---SDLQEIIKEISIMQQCDSPY 81
Query: 121 VVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGL 180
VV YY S+ +LW+VM+ GS+ DII+ +N L E IATILK L+GL
Sbjct: 82 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRL-------RNKTLIEDEIATILKSTLKGL 134
Query: 181 DYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMA 240
+YLH +IHRD+KAGNILL +G ++ADFGV+ L T K R T +GTP WMA
Sbjct: 135 EYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTD----TMAK-RNTVIGTPFWMA 189
Query: 241 PEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDK 300
PEV++++ GY+ AD+WS GIT+IE+A G PY PM+ + + N PPT
Sbjct: 190 PEVIQEI-GYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTF------- 241
Query: 301 EMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQR 360
+ + F + CL K+P +R TA +LL+ F + AK ++ L+T +I
Sbjct: 242 RKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVS-ILRDLITEAMEI--- 297
Query: 361 AKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKEENPEIAVSAS 420
K +R L + E+ +DE+D + + S R + S
Sbjct: 298 --KAKRHEEQQRELEEEEENS---DEDELDSHTMVKTSVESVGTMR-----------ATS 341
Query: 421 TIPEQIQSLSVHDS 434
T+ E Q++ H+S
Sbjct: 342 TMSEGAQTMIEHNS 355
>gi|109633028 serine/threonine protein kinase MST4 isoform 2 [Homo
sapiens]
Length = 339
Score = 192 bits (487), Expect = 9e-49
Identities = 125/303 (41%), Positives = 168/303 (55%), Gaps = 53/303 (17%)
Query: 133 ELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRD 192
+LW++M+ L GGS LD+++ G +E IAT+LKE+L+GLDYLH +IHRD
Sbjct: 17 KLWIIMEYLGGGSALDLLRA---------GPFDEFQIATMLKEILKGLDYLHSEKKIHRD 67
Query: 193 LKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKV-RKTFVGTPCWMAPEVMEQVRGYD 251
+KA N+LL E G V++ADFGV+ G +T ++ R TFVGTP WMAPEV++Q YD
Sbjct: 68 IKAANVLLSEQGDVKLADFGVA------GQLTDTQIKRNTFVGTPFWMAPEVIQQ-SAYD 120
Query: 252 FKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFR 311
KAD+WS GITAIELA G P PM+VL L +N+PPTL + + KSF+
Sbjct: 121 SKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTL---------VGDFTKSFK 171
Query: 312 KLLSLCLQKDPSKRPTAAELLKCKFFQK-AKNREYLIEKLLTRTPDIAQRAKKVRRVPGS 370
+ + CL KDPS RPTA ELLK KF K +K YL E + R K+ + +
Sbjct: 172 EFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTE--------LIDRFKRWK----A 219
Query: 371 SGHLHKTEDGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKEENPEIAVSASTIPEQIQSLS 430
GH SDDE D EG + S + E V P+++Q+ +
Sbjct: 220 EGH-----------SDDESD---SEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGA 265
Query: 431 VHD 433
D
Sbjct: 266 EQD 268
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 189 bits (481), Expect = 4e-48
Identities = 121/314 (38%), Positives = 171/314 (54%), Gaps = 28/314 (8%)
Query: 56 WPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRIN-LEKCQTSMDELLKEIQAMS 114
+P D +E+ E IG G V L K ++ A+K ++ + ++ ++A+S
Sbjct: 14 FPDPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKALS 73
Query: 115 QCSHPNVVTYYTSFVVKDE-----LWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAII 169
HPNVV +Y + KD+ LWLV++L SGGS+ D++K + RGE + E +I
Sbjct: 74 D--HPNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGER----MSEPLI 127
Query: 170 ATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVR 229
A IL E L GL +LH N IHRD+K NILL +G V++ DFGVSA L + TR++ R
Sbjct: 128 AYILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTS----TRHR-R 182
Query: 230 KTFVGTPCWMAPEVM----EQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLT 285
T VGTP WMAPEV+ + YD + D WS GITAIEL G P PM+ L
Sbjct: 183 NTSVGTPFWMAPEVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKI 242
Query: 286 LQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREY 345
+N PP L + + F +S CL KD KRPT +ELL+ KF + + ++
Sbjct: 243 PRNPPPKL-------RQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDV 295
Query: 346 LIEKLLTRTPDIAQ 359
+++K LT I Q
Sbjct: 296 MLQKQLTEFIGIHQ 309
>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
Length = 545
Score = 186 bits (471), Expect = 6e-47
Identities = 112/289 (38%), Positives = 162/289 (56%), Gaps = 25/289 (8%)
Query: 53 AVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQA 112
+VG P + Y E IG GA+ V A+ + VAIK++NL++ Q + ++ EI
Sbjct: 262 SVGDP--KKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQ-QPKKELIINEILV 318
Query: 113 MSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATI 172
M + +PN+V Y S++V DELW+VM+ L+GGS+ D++ ++E IA +
Sbjct: 319 MRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVT---------ETCMDEGQIAAV 369
Query: 173 LKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTF 232
+E L+ L++LH N IHRD+K+ NILLG DGSV++ DFG A + R T
Sbjct: 370 CRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI-----TPEQSKRSTM 424
Query: 233 VGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPT 292
VGTP WMAPEV+ + + Y K D+WS GI AIE+ G PY P++ L L N P
Sbjct: 425 VGTPYWMAPEVVTR-KAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPE 483
Query: 293 LETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAK 341
L+ +K FR L+ CL+ D KR +A ELL+ +F + AK
Sbjct: 484 LQN-------PEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAK 525
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 185 bits (470), Expect = 8e-47
Identities = 112/289 (38%), Positives = 161/289 (55%), Gaps = 25/289 (8%)
Query: 53 AVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQA 112
+VG P + Y E IG GA+ V AL + VAIK++NL++ Q + ++ EI
Sbjct: 275 SVGDP--KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILV 331
Query: 113 MSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATI 172
M + +PN+V Y S++V DELW+VM+ L+GGS+ D++ ++E IA +
Sbjct: 332 MRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVT---------ETCMDEGQIAAV 382
Query: 173 LKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTF 232
+E L+ LD+LH N IHRD+K+ NILLG DGSV++ DFG A + R T
Sbjct: 383 CRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI-----TPEQSKRSTM 437
Query: 233 VGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPT 292
VGTP WMAPEV+ + + Y K D+WS GI AIE+ G PY P++ L L N P
Sbjct: 438 VGTPYWMAPEVVTR-KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPE 496
Query: 293 LETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAK 341
L+ ++ FR L+ CL+ D +R +A ELL+ F + AK
Sbjct: 497 LQN-------PERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAK 538
>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
Length = 565
Score = 185 bits (470), Expect = 8e-47
Identities = 112/289 (38%), Positives = 161/289 (55%), Gaps = 25/289 (8%)
Query: 53 AVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQA 112
+VG P + Y E IG GA+ V AL + VAIK++NL++ Q + ++ EI
Sbjct: 281 SVGDP--KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILV 337
Query: 113 MSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATI 172
M + +PN+V Y S++V DELW+VM+ L+GGS+ D++ ++E IA +
Sbjct: 338 MRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVT---------ETCMDEGQIAAV 388
Query: 173 LKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTF 232
+E L+ LD+LH N IHRD+K+ NILLG DGSV++ DFG A + R T
Sbjct: 389 CRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI-----TPEQSKRSTM 443
Query: 233 VGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPT 292
VGTP WMAPEV+ + + Y K D+WS GI AIE+ G PY P++ L L N P
Sbjct: 444 VGTPYWMAPEVVTR-KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPE 502
Query: 293 LETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAK 341
L+ ++ FR L+ CL+ D +R +A ELL+ F + AK
Sbjct: 503 LQN-------PERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAK 544
>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
Length = 580
Score = 185 bits (470), Expect = 8e-47
Identities = 112/289 (38%), Positives = 161/289 (55%), Gaps = 25/289 (8%)
Query: 53 AVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQA 112
+VG P + Y E IG GA+ V AL + VAIK++NL++ Q + ++ EI
Sbjct: 296 SVGDP--KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILV 352
Query: 113 MSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATI 172
M + +PN+V Y S++V DELW+VM+ L+GGS+ D++ ++E IA +
Sbjct: 353 MRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVT---------ETCMDEGQIAAV 403
Query: 173 LKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTF 232
+E L+ LD+LH N IHRD+K+ NILLG DGSV++ DFG A + R T
Sbjct: 404 CRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI-----TPEQSKRSTM 458
Query: 233 VGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPT 292
VGTP WMAPEV+ + + Y K D+WS GI AIE+ G PY P++ L L N P
Sbjct: 459 VGTPYWMAPEVVTR-KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPE 517
Query: 293 LETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAK 341
L+ ++ FR L+ CL+ D +R +A ELL+ F + AK
Sbjct: 518 LQN-------PERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAK 559
>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 185 bits (470), Expect = 8e-47
Identities = 112/289 (38%), Positives = 161/289 (55%), Gaps = 25/289 (8%)
Query: 53 AVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQA 112
+VG P + Y E IG GA+ V AL + VAIK++NL++ Q + ++ EI
Sbjct: 260 SVGDP--KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILV 316
Query: 113 MSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATI 172
M + +PN+V Y S++V DELW+VM+ L+GGS+ D++ ++E IA +
Sbjct: 317 MRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVT---------ETCMDEGQIAAV 367
Query: 173 LKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTF 232
+E L+ LD+LH N IHRD+K+ NILLG DGSV++ DFG A + R T
Sbjct: 368 CRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI-----TPEQSKRSTM 422
Query: 233 VGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPT 292
VGTP WMAPEV+ + + Y K D+WS GI AIE+ G PY P++ L L N P
Sbjct: 423 VGTPYWMAPEVVTR-KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPE 481
Query: 293 LETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAK 341
L+ ++ FR L+ CL+ D +R +A ELL+ F + AK
Sbjct: 482 LQN-------PERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAK 523
>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 185 bits (470), Expect = 8e-47
Identities = 112/289 (38%), Positives = 161/289 (55%), Gaps = 25/289 (8%)
Query: 53 AVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQA 112
+VG P + Y E IG GA+ V AL + VAIK++NL++ Q + ++ EI
Sbjct: 260 SVGDP--KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILV 316
Query: 113 MSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATI 172
M + +PN+V Y S++V DELW+VM+ L+GGS+ D++ ++E IA +
Sbjct: 317 MRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVT---------ETCMDEGQIAAV 367
Query: 173 LKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTF 232
+E L+ LD+LH N IHRD+K+ NILLG DGSV++ DFG A + R T
Sbjct: 368 CRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI-----TPEQSKRSTM 422
Query: 233 VGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPT 292
VGTP WMAPEV+ + + Y K D+WS GI AIE+ G PY P++ L L N P
Sbjct: 423 VGTPYWMAPEVVTR-KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPE 481
Query: 293 LETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAK 341
L+ ++ FR L+ CL+ D +R +A ELL+ F + AK
Sbjct: 482 LQN-------PERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAK 523
>gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 185 bits (470), Expect = 8e-47
Identities = 112/289 (38%), Positives = 161/289 (55%), Gaps = 25/289 (8%)
Query: 53 AVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQA 112
+VG P + Y E IG GA+ V AL + VAIK++NL++ Q + ++ EI
Sbjct: 260 SVGDP--KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILV 316
Query: 113 MSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATI 172
M + +PN+V Y S++V DELW+VM+ L+GGS+ D++ ++E IA +
Sbjct: 317 MRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVT---------ETCMDEGQIAAV 367
Query: 173 LKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTF 232
+E L+ LD+LH N IHRD+K+ NILLG DGSV++ DFG A + R T
Sbjct: 368 CRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI-----TPEQSKRSTM 422
Query: 233 VGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPT 292
VGTP WMAPEV+ + + Y K D+WS GI AIE+ G PY P++ L L N P
Sbjct: 423 VGTPYWMAPEVVTR-KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPE 481
Query: 293 LETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAK 341
L+ ++ FR L+ CL+ D +R +A ELL+ F + AK
Sbjct: 482 LQN-------PERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAK 523
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 184 bits (468), Expect = 1e-46
Identities = 120/295 (40%), Positives = 166/295 (56%), Gaps = 25/295 (8%)
Query: 60 RDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHP 119
++ +EL + IGSG V A E AIK I LE + + +EI M C HP
Sbjct: 13 QEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGE-DFAVVQQEIIMMKDCKHP 71
Query: 120 NVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEG 179
N+V Y+ S++ +D+LW+ M+ GGS+ DI H G L E IA + +E L+G
Sbjct: 72 NIVAYFGSYLRRDKLWICMEFCGGGSLQDIY--------HVTGPLSELQIAYVSRETLQG 123
Query: 180 LDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWM 239
L YLH G++HRD+K NILL ++G V++ADFGVSA + T K RK+F+GTP WM
Sbjct: 124 LYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQIT----ATIAK-RKSFIGTPYWM 178
Query: 240 APEV--MEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQND--PPTLET 295
APEV +E+ GY+ D+W+ GITAIELA P PM+ L L +++ PP L
Sbjct: 179 APEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKL-- 236
Query: 296 GVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKL 350
+DK K+ SF + + L K+P KRPTA +LL+ F + R IE L
Sbjct: 237 --KDK---MKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELL 286
>gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 183 bits (464), Expect = 4e-46
Identities = 130/362 (35%), Positives = 183/362 (50%), Gaps = 45/362 (12%)
Query: 1 MAEPSGSPVHVQLPQQA--AP---VTAAAAAAPAAATAAPAPAAPAAPAP----APAPAA 51
+A P S + P +A AP V A+ P A A PAAPA P P +P
Sbjct: 237 LAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREP 296
Query: 52 QAVGWPICRDAYELQE-------------VIGSGATAVVQAALCKPRQERVAIKRINLEK 98
Q V R A +L IG G+T +V A + + VA+K+++L K
Sbjct: 297 QRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRK 356
Query: 99 CQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGE 158
Q + L E+ M H NVV Y S++V DELW+VM+ L GG++ DI+ +
Sbjct: 357 -QQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR---- 411
Query: 159 HKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLA 218
+ E IA + VL+ L LH G IHRD+K+ +ILL DG V+++DFG A ++
Sbjct: 412 -----MNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVS 466
Query: 219 TGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPP 278
+V R RK+ VGTP WMAPE++ ++ Y + D+WS GI IE+ G PY PP
Sbjct: 467 K--EVPR---RKSLVGTPYWMAPELISRL-PYGPEVDIWSLGIMVIEMVDGEPPYFNEPP 520
Query: 279 MKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQ 338
+K + + N PP L+ + K S + L L +DP++R TAAELLK F
Sbjct: 521 LKAMKMIRDNLPPRLKN-------LHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLA 573
Query: 339 KA 340
KA
Sbjct: 574 KA 575
>gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens]
Length = 438
Score = 183 bits (464), Expect = 4e-46
Identities = 130/362 (35%), Positives = 183/362 (50%), Gaps = 45/362 (12%)
Query: 1 MAEPSGSPVHVQLPQQA--AP---VTAAAAAAPAAATAAPAPAAPAAPAP----APAPAA 51
+A P S + P +A AP V A+ P A A PAAPA P P +P
Sbjct: 84 LAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREP 143
Query: 52 QAVGWPICRDAYELQE-------------VIGSGATAVVQAALCKPRQERVAIKRINLEK 98
Q V R A +L IG G+T +V A + + VA+K+++L K
Sbjct: 144 QRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRK 203
Query: 99 CQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGE 158
Q + L E+ M H NVV Y S++V DELW+VM+ L GG++ DI+ +
Sbjct: 204 -QQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR---- 258
Query: 159 HKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLA 218
+ E IA + VL+ L LH G IHRD+K+ +ILL DG V+++DFG A ++
Sbjct: 259 -----MNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVS 313
Query: 219 TGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPP 278
+V R RK+ VGTP WMAPE++ ++ Y + D+WS GI IE+ G PY PP
Sbjct: 314 K--EVPR---RKSLVGTPYWMAPELISRL-PYGPEVDIWSLGIMVIEMVDGEPPYFNEPP 367
Query: 279 MKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQ 338
+K + + N PP L+ + K S + L L +DP++R TAAELLK F
Sbjct: 368 LKAMKMIRDNLPPRLKN-------LHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLA 420
Query: 339 KA 340
KA
Sbjct: 421 KA 422
>gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens]
Length = 438
Score = 183 bits (464), Expect = 4e-46
Identities = 130/362 (35%), Positives = 183/362 (50%), Gaps = 45/362 (12%)
Query: 1 MAEPSGSPVHVQLPQQA--AP---VTAAAAAAPAAATAAPAPAAPAAPAP----APAPAA 51
+A P S + P +A AP V A+ P A A PAAPA P P +P
Sbjct: 84 LAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREP 143
Query: 52 QAVGWPICRDAYELQE-------------VIGSGATAVVQAALCKPRQERVAIKRINLEK 98
Q V R A +L IG G+T +V A + + VA+K+++L K
Sbjct: 144 QRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRK 203
Query: 99 CQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGE 158
Q + L E+ M H NVV Y S++V DELW+VM+ L GG++ DI+ +
Sbjct: 204 -QQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR---- 258
Query: 159 HKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLA 218
+ E IA + VL+ L LH G IHRD+K+ +ILL DG V+++DFG A ++
Sbjct: 259 -----MNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVS 313
Query: 219 TGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPP 278
+V R RK+ VGTP WMAPE++ ++ Y + D+WS GI IE+ G PY PP
Sbjct: 314 K--EVPR---RKSLVGTPYWMAPELISRL-PYGPEVDIWSLGIMVIEMVDGEPPYFNEPP 367
Query: 279 MKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQ 338
+K + + N PP L+ + K S + L L +DP++R TAAELLK F
Sbjct: 368 LKAMKMIRDNLPPRLKN-------LHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLA 420
Query: 339 KA 340
KA
Sbjct: 421 KA 422
>gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 183 bits (464), Expect = 4e-46
Identities = 130/362 (35%), Positives = 183/362 (50%), Gaps = 45/362 (12%)
Query: 1 MAEPSGSPVHVQLPQQA--AP---VTAAAAAAPAAATAAPAPAAPAAPAP----APAPAA 51
+A P S + P +A AP V A+ P A A PAAPA P P +P
Sbjct: 237 LAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREP 296
Query: 52 QAVGWPICRDAYELQE-------------VIGSGATAVVQAALCKPRQERVAIKRINLEK 98
Q V R A +L IG G+T +V A + + VA+K+++L K
Sbjct: 297 QRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRK 356
Query: 99 CQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGE 158
Q + L E+ M H NVV Y S++V DELW+VM+ L GG++ DI+ +
Sbjct: 357 -QQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR---- 411
Query: 159 HKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLA 218
+ E IA + VL+ L LH G IHRD+K+ +ILL DG V+++DFG A ++
Sbjct: 412 -----MNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVS 466
Query: 219 TGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPP 278
+V R RK+ VGTP WMAPE++ ++ Y + D+WS GI IE+ G PY PP
Sbjct: 467 K--EVPR---RKSLVGTPYWMAPELISRL-PYGPEVDIWSLGIMVIEMVDGEPPYFNEPP 520
Query: 279 MKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQ 338
+K + + N PP L+ + K S + L L +DP++R TAAELLK F
Sbjct: 521 LKAMKMIRDNLPPRLKN-------LHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLA 573
Query: 339 KA 340
KA
Sbjct: 574 KA 575
>gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 183 bits (464), Expect = 4e-46
Identities = 130/362 (35%), Positives = 183/362 (50%), Gaps = 45/362 (12%)
Query: 1 MAEPSGSPVHVQLPQQA--AP---VTAAAAAAPAAATAAPAPAAPAAPAP----APAPAA 51
+A P S + P +A AP V A+ P A A PAAPA P P +P
Sbjct: 237 LAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREP 296
Query: 52 QAVGWPICRDAYELQE-------------VIGSGATAVVQAALCKPRQERVAIKRINLEK 98
Q V R A +L IG G+T +V A + + VA+K+++L K
Sbjct: 297 QRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRK 356
Query: 99 CQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGE 158
Q + L E+ M H NVV Y S++V DELW+VM+ L GG++ DI+ +
Sbjct: 357 -QQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR---- 411
Query: 159 HKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLA 218
+ E IA + VL+ L LH G IHRD+K+ +ILL DG V+++DFG A ++
Sbjct: 412 -----MNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVS 466
Query: 219 TGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPP 278
+V R RK+ VGTP WMAPE++ ++ Y + D+WS GI IE+ G PY PP
Sbjct: 467 K--EVPR---RKSLVGTPYWMAPELISRL-PYGPEVDIWSLGIMVIEMVDGEPPYFNEPP 520
Query: 279 MKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQ 338
+K + + N PP L+ + K S + L L +DP++R TAAELLK F
Sbjct: 521 LKAMKMIRDNLPPRLKN-------LHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLA 573
Query: 339 KA 340
KA
Sbjct: 574 KA 575
>gi|32483399 p21-activated kinase 2 [Homo sapiens]
Length = 524
Score = 182 bits (461), Expect = 9e-46
Identities = 108/279 (38%), Positives = 156/279 (55%), Gaps = 23/279 (8%)
Query: 63 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVV 122
Y E IG GA+ V A + VAIK+INL+K Q + ++ EI M + +PN+V
Sbjct: 249 YTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQK-QPKKELIINEILVMKELKNPNIV 307
Query: 123 TYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDY 182
+ S++V DEL++VM+ L+GGS+ D++ ++EA IA + +E L+ L++
Sbjct: 308 NFLDSYLVGDELFVVMEYLAGGSLTDVVT---------ETCMDEAQIAAVCRECLQALEF 358
Query: 183 LHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPE 242
LH N IHRD+K+ N+LLG +GSV++ DFG A + R T VGTP WMAPE
Sbjct: 359 LHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQI-----TPEQSKRSTMVGTPYWMAPE 413
Query: 243 VMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEM 302
V+ + + Y K D+WS GI AIE+ G PY P++ L L N P L+
Sbjct: 414 VVTR-KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQN------- 465
Query: 303 MKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAK 341
+K FR L+ CL+ D KR +A ELL+ F + AK
Sbjct: 466 PEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAK 504
>gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
Length = 553
Score = 182 bits (461), Expect = 9e-46
Identities = 109/283 (38%), Positives = 158/283 (55%), Gaps = 25/283 (8%)
Query: 53 AVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQA 112
+VG P + Y E IG GA+ V A+ + VAIK++NL++ Q + ++ EI
Sbjct: 262 SVGDP--KKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQ-QPKKELIINEILV 318
Query: 113 MSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATI 172
M + +PN+V Y S++V DELW+VM+ L+GGS+ D++ ++E IA +
Sbjct: 319 MRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVT---------ETCMDEGQIAAV 369
Query: 173 LKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTF 232
+E L+ L++LH N IHRD+K+ NILLG DGSV++ DFG A + R T
Sbjct: 370 CRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI-----TPEQSKRSTM 424
Query: 233 VGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPT 292
VGTP WMAPEV+ + + Y K D+WS GI AIE+ G PY P++ L L N P
Sbjct: 425 VGTPYWMAPEVVTR-KAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPE 483
Query: 293 LETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCK 335
L+ +K FR L+ CL+ D KR +A ELL+ +
Sbjct: 484 LQN-------PEKLSAIFRDFLNRCLEMDVEKRGSAKELLQVR 519
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 181 bits (460), Expect = 1e-45
Identities = 128/364 (35%), Positives = 190/364 (52%), Gaps = 48/364 (13%)
Query: 46 APAPAAQAVGWPICRDA---YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTS 102
+PA + + RD +EL E++G+G V + AIK +++ +
Sbjct: 5 SPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE- 63
Query: 103 MDELLKEIQAMSQCSHP-NVVTYYTSFVVK------DELWLVMKLLSGGSMLDIIKYIVN 155
+E+ +EI + + SH N+ TYY +F+ K D+LWLVM+ GS+ D+IK
Sbjct: 64 -EEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIK---- 118
Query: 156 RGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSA 215
K L+E IA I +E+L GL +LH++ IHRD+K N+LL E+ V++ DFGVSA
Sbjct: 119 --NTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSA 176
Query: 216 FLATGGDVTRNKVRKTFVGTPCWMAPEVM----EQVRGYDFKADMWSFGITAIELATGAA 271
L D T + R TF+GTP WMAPEV+ YDFK+D+WS GITAIE+A GA
Sbjct: 177 QL----DRTVGR-RNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAP 231
Query: 272 PYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAEL 331
P PM+ L L +N P L++ KK+ K F+ + CL K+ S+RP +L
Sbjct: 232 PLCDMHPMRALFLIPRNPAPRLKS--------KKWSKKFQSFIESCLVKNHSQRPATEQL 283
Query: 332 LKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDE 391
+K F + N ++ + D R KK R G +TE +E+S E +E
Sbjct: 284 MKHPFIRDQPNE----RQVRIQLKDHIDRTKKKR------GEKDETE---YEYSGSEEEE 330
Query: 392 KSEE 395
+ +
Sbjct: 331 EEND 334
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 181 bits (460), Expect = 1e-45
Identities = 128/364 (35%), Positives = 190/364 (52%), Gaps = 48/364 (13%)
Query: 46 APAPAAQAVGWPICRDA---YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTS 102
+PA + + RD +EL E++G+G V + AIK +++ +
Sbjct: 5 SPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE- 63
Query: 103 MDELLKEIQAMSQCSHP-NVVTYYTSFVVK------DELWLVMKLLSGGSMLDIIKYIVN 155
+E+ +EI + + SH N+ TYY +F+ K D+LWLVM+ GS+ D+IK
Sbjct: 64 -EEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIK---- 118
Query: 156 RGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSA 215
K L+E IA I +E+L GL +LH++ IHRD+K N+LL E+ V++ DFGVSA
Sbjct: 119 --NTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSA 176
Query: 216 FLATGGDVTRNKVRKTFVGTPCWMAPEVM----EQVRGYDFKADMWSFGITAIELATGAA 271
L D T + R TF+GTP WMAPEV+ YDFK+D+WS GITAIE+A GA
Sbjct: 177 QL----DRTVGR-RNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAP 231
Query: 272 PYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAEL 331
P PM+ L L +N P L++ KK+ K F+ + CL K+ S+RP +L
Sbjct: 232 PLCDMHPMRALFLIPRNPAPRLKS--------KKWSKKFQSFIESCLVKNHSQRPATEQL 283
Query: 332 LKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDE 391
+K F + N ++ + D R KK R G +TE +E+S E +E
Sbjct: 284 MKHPFIRDQPNE----RQVRIQLKDHIDRTKKKR------GEKDETE---YEYSGSEEEE 330
Query: 392 KSEE 395
+ +
Sbjct: 331 EEND 334
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 181 bits (460), Expect = 1e-45
Identities = 128/364 (35%), Positives = 190/364 (52%), Gaps = 48/364 (13%)
Query: 46 APAPAAQAVGWPICRDA---YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTS 102
+PA + + RD +EL E++G+G V + AIK +++ +
Sbjct: 5 SPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE- 63
Query: 103 MDELLKEIQAMSQCSHP-NVVTYYTSFVVK------DELWLVMKLLSGGSMLDIIKYIVN 155
+E+ +EI + + SH N+ TYY +F+ K D+LWLVM+ GS+ D+IK
Sbjct: 64 -EEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIK---- 118
Query: 156 RGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSA 215
K L+E IA I +E+L GL +LH++ IHRD+K N+LL E+ V++ DFGVSA
Sbjct: 119 --NTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSA 176
Query: 216 FLATGGDVTRNKVRKTFVGTPCWMAPEVM----EQVRGYDFKADMWSFGITAIELATGAA 271
L D T + R TF+GTP WMAPEV+ YDFK+D+WS GITAIE+A GA
Sbjct: 177 QL----DRTVGR-RNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAP 231
Query: 272 PYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAEL 331
P PM+ L L +N P L++ KK+ K F+ + CL K+ S+RP +L
Sbjct: 232 PLCDMHPMRALFLIPRNPAPRLKS--------KKWSKKFQSFIESCLVKNHSQRPATEQL 283
Query: 332 LKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDE 391
+K F + N ++ + D R KK R G +TE +E+S E +E
Sbjct: 284 MKHPFIRDQPNE----RQVRIQLKDHIDRTKKKR------GEKDETE---YEYSGSEEEE 330
Query: 392 KSEE 395
+ +
Sbjct: 331 EEND 334
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 181 bits (460), Expect = 1e-45
Identities = 128/364 (35%), Positives = 190/364 (52%), Gaps = 48/364 (13%)
Query: 46 APAPAAQAVGWPICRDA---YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTS 102
+PA + + RD +EL E++G+G V + AIK +++ +
Sbjct: 5 SPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE- 63
Query: 103 MDELLKEIQAMSQCSHP-NVVTYYTSFVVK------DELWLVMKLLSGGSMLDIIKYIVN 155
+E+ +EI + + SH N+ TYY +F+ K D+LWLVM+ GS+ D+IK
Sbjct: 64 -EEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIK---- 118
Query: 156 RGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSA 215
K L+E IA I +E+L GL +LH++ IHRD+K N+LL E+ V++ DFGVSA
Sbjct: 119 --NTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSA 176
Query: 216 FLATGGDVTRNKVRKTFVGTPCWMAPEVM----EQVRGYDFKADMWSFGITAIELATGAA 271
L D T + R TF+GTP WMAPEV+ YDFK+D+WS GITAIE+A GA
Sbjct: 177 QL----DRTVGR-RNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAP 231
Query: 272 PYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAEL 331
P PM+ L L +N P L++ KK+ K F+ + CL K+ S+RP +L
Sbjct: 232 PLCDMHPMRALFLIPRNPAPRLKS--------KKWSKKFQSFIESCLVKNHSQRPATEQL 283
Query: 332 LKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDE 391
+K F + N ++ + D R KK R G +TE +E+S E +E
Sbjct: 284 MKHPFIRDQPNE----RQVRIQLKDHIDRTKKKR------GEKDETE---YEYSGSEEEE 330
Query: 392 KSEE 395
+ +
Sbjct: 331 EEND 334
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 181 bits (460), Expect = 1e-45
Identities = 128/364 (35%), Positives = 190/364 (52%), Gaps = 48/364 (13%)
Query: 46 APAPAAQAVGWPICRDA---YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTS 102
+PA + + RD +EL E++G+G V + AIK +++ +
Sbjct: 5 SPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE- 63
Query: 103 MDELLKEIQAMSQCSHP-NVVTYYTSFVVK------DELWLVMKLLSGGSMLDIIKYIVN 155
+E+ +EI + + SH N+ TYY +F+ K D+LWLVM+ GS+ D+IK
Sbjct: 64 -EEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIK---- 118
Query: 156 RGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSA 215
K L+E IA I +E+L GL +LH++ IHRD+K N+LL E+ V++ DFGVSA
Sbjct: 119 --NTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSA 176
Query: 216 FLATGGDVTRNKVRKTFVGTPCWMAPEVM----EQVRGYDFKADMWSFGITAIELATGAA 271
L D T + R TF+GTP WMAPEV+ YDFK+D+WS GITAIE+A GA
Sbjct: 177 QL----DRTVGR-RNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAP 231
Query: 272 PYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAEL 331
P PM+ L L +N P L++ KK+ K F+ + CL K+ S+RP +L
Sbjct: 232 PLCDMHPMRALFLIPRNPAPRLKS--------KKWSKKFQSFIESCLVKNHSQRPATEQL 283
Query: 332 LKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDE 391
+K F + N ++ + D R KK R G +TE +E+S E +E
Sbjct: 284 MKHPFIRDQPNE----RQVRIQLKDHIDRTKKKR------GEKDETE---YEYSGSEEEE 330
Query: 392 KSEE 395
+ +
Sbjct: 331 EEND 334
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,538,989
Number of Sequences: 37866
Number of extensions: 1046497
Number of successful extensions: 23305
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1114
Number of HSP's successfully gapped in prelim test: 349
Number of HSP's that attempted gapping in prelim test: 13243
Number of HSP's gapped (non-prelim): 6274
length of query: 545
length of database: 18,247,518
effective HSP length: 107
effective length of query: 438
effective length of database: 14,195,856
effective search space: 6217784928
effective search space used: 6217784928
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.