Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 224593756
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224593756 hypothetical protein LOC164127 [Homo sapiens]
(623 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224593756 hypothetical protein LOC164127 [Homo sapiens] 1259 0.0
gi|148746195 trichohyalin [Homo sapiens] 100 7e-21
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 79 1e-14
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 78 3e-14
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 78 3e-14
gi|239756174 PREDICTED: hypothetical protein [Homo sapiens] 77 4e-14
gi|239750672 PREDICTED: hypothetical protein [Homo sapiens] 77 4e-14
gi|239744982 PREDICTED: hypothetical protein [Homo sapiens] 77 4e-14
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 76 1e-13
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 76 1e-13
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 76 1e-13
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 76 1e-13
gi|21735548 centrosomal protein 2 [Homo sapiens] 76 1e-13
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 75 2e-13
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 75 2e-13
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 74 3e-13
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 74 3e-13
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 74 3e-13
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 74 4e-13
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 74 4e-13
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 74 4e-13
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 74 4e-13
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 74 4e-13
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 74 4e-13
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 74 4e-13
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 74 4e-13
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 74 4e-13
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 73 9e-13
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 71 3e-12
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 71 3e-12
>gi|224593756 hypothetical protein LOC164127 [Homo sapiens]
Length = 623
Score = 1259 bits (3257), Expect = 0.0
Identities = 623/623 (100%), Positives = 623/623 (100%)
Query: 1 MAGFSHFSQPPYRDLWEPPRPGGERESTQRLGGQRSGADSTACSRAGTPGAESEAGACWL 60
MAGFSHFSQPPYRDLWEPPRPGGERESTQRLGGQRSGADSTACSRAGTPGAESEAGACWL
Sbjct: 1 MAGFSHFSQPPYRDLWEPPRPGGERESTQRLGGQRSGADSTACSRAGTPGAESEAGACWL 60
Query: 61 HPHCSFTPRPRRRGCSDSLRGSRSLSDVARRPLERSRKHRPRSRRLEDAWGETGTKPRPA 120
HPHCSFTPRPRRRGCSDSLRGSRSLSDVARRPLERSRKHRPRSRRLEDAWGETGTKPRPA
Sbjct: 61 HPHCSFTPRPRRRGCSDSLRGSRSLSDVARRPLERSRKHRPRSRRLEDAWGETGTKPRPA 120
Query: 121 WQPQTQLPPQRPQPCPHYPLAQGDSPPPCPGGAGTPLSGTFRVEKAQGGDQWAVPLGRHL 180
WQPQTQLPPQRPQPCPHYPLAQGDSPPPCPGGAGTPLSGTFRVEKAQGGDQWAVPLGRHL
Sbjct: 121 WQPQTQLPPQRPQPCPHYPLAQGDSPPPCPGGAGTPLSGTFRVEKAQGGDQWAVPLGRHL 180
Query: 181 GRWSPSSVPSERSSVPSQKFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRSPHT 240
GRWSPSSVPSERSSVPSQKFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRSPHT
Sbjct: 181 GRWSPSSVPSERSSVPSQKFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRSPHT 240
Query: 241 QVLKSKLEEVVVSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLER 300
QVLKSKLEEVVVSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLER
Sbjct: 241 QVLKSKLEEVVVSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLER 300
Query: 301 ERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEK 360
ERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEK
Sbjct: 301 ERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEK 360
Query: 361 LEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQ 420
LEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQ
Sbjct: 361 LEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQ 420
Query: 421 DTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQK 480
DTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQK
Sbjct: 421 DTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQK 480
Query: 481 EEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLRE 540
EEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLRE
Sbjct: 481 EEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLRE 540
Query: 541 KNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREERAP 600
KNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREERAP
Sbjct: 541 KNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREERAP 600
Query: 601 PNSSLDQMVLEAQLRACQQNRGY 623
PNSSLDQMVLEAQLRACQQNRGY
Sbjct: 601 PNSSLDQMVLEAQLRACQQNRGY 623
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 99.8 bits (247), Expect = 7e-21
Identities = 99/427 (23%), Positives = 195/427 (45%), Gaps = 29/427 (6%)
Query: 210 QKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKK 269
++RD + E L R Q +E R+ Q+ K E ++Q+ L L++
Sbjct: 162 EQRDRQRRDEELW-RQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRR 220
Query: 270 AQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRG 329
R E QQQ + + + + +++ + R+R +LR+ +E+ QE+E ++ + E+
Sbjct: 221 KGR-EEKQQQRRERQDRVFQEEEEKEW---RKRETVLRKEEEKLQEEEPQRQRELQEEEE 276
Query: 330 LRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNL 389
R +R+ E R + Q E+Q+ R + ++ R + E ++ Q REQ++
Sbjct: 277 QLRKLERQ-----ELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQ 331
Query: 390 REQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLR- 448
E+ QL+R E ++ E +++ Q + +++ + Q + E+ LR
Sbjct: 332 EERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRR 391
Query: 449 --QLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRIL 506
QL EQ +R Q++ + + R+++LR + Q EQ ++ + E E + + KR
Sbjct: 392 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQ 451
Query: 507 VELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKL----KAEKEEKCHIEGIK 562
E D R+ + H+ R K Q R+ E+ LKL + E++E+ + +
Sbjct: 452 EERRDWLKREEETERHEQERRKQQLKRDQE--EERRERWLKLEEEERREQQERREQQLRR 509
Query: 563 EAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREE--------RAPPNSSLDQMVLEAQL 614
E +++EQR++ Q ++ Q+ + Q RRE+ + L+Q E +L
Sbjct: 510 EQEERREQRLKR--QEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRL 567
Query: 615 RACQQNR 621
+ Q+ R
Sbjct: 568 KREQEER 574
Score = 90.9 bits (224), Expect = 3e-18
Identities = 82/386 (21%), Positives = 184/386 (47%), Gaps = 25/386 (6%)
Query: 225 DSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTR--LKKAQRIRELQQQAAK 282
+ Q L + R Q L+S+ E ++QQ+ R L++ Q++R ++ +
Sbjct: 1490 EEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQR 1549
Query: 283 AWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPG 342
+ ++ ++ Q+ ERE + L RQ +++ E++K + ++R D Q+ G
Sbjct: 1550 RQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEG 1609
Query: 343 ESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNLREQH-------SL 395
+ + +++ + + ++ L++ Q HR++ + L E+ ++ R REQ
Sbjct: 1610 QQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKF 1669
Query: 396 QLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQS 455
+ + +L++ ++ L E +K ++ + RK L + E+ LR+ LE+
Sbjct: 1670 REEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQE-----EQQLRRQELERK 1724
Query: 456 FQRSQEIHQGLRKER-QRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKI 514
F+ +++ Q +E+ +R+ R + EEEQL+ R E+Q + ++R +E++
Sbjct: 1725 FREEEQLRQETEQEQLRRQERYRKILEEEQLRPER-----EEQQLRRQERDRKFREEEQL 1779
Query: 515 RQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQH 574
RQ R +++ + RE LR++ +++ K E + ++++EQR++
Sbjct: 1780 RQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLR- 1838
Query: 575 ISQGKDPNFQEFQKL--PQASRREER 598
Q +D ++ ++ + SRREE+
Sbjct: 1839 --QERDRQYRAEEQFATQEKSRREEQ 1862
Score = 87.8 bits (216), Expect = 3e-17
Identities = 80/395 (20%), Positives = 188/395 (47%), Gaps = 18/395 (4%)
Query: 210 QKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKK 269
++R +Q + R+ Q +E R + + + E Q ++ L R ++
Sbjct: 288 RERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQER---REQQEERREQQLRREQE 344
Query: 270 AQRIREL--QQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQ 327
+R ++L +Q+ + ++L+R ++ + + R LR+ Q+ +E++ R+ Q +
Sbjct: 345 ERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRRE 404
Query: 328 RGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRR--LREQEKM 385
+ LRR+ Q + + + E +E ++K E+ R + +++ + RR L+ +E+
Sbjct: 405 QQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEET 464
Query: 386 LRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEE 445
R+ +E+ QL+R E R+R L E +++ Q + +++ + + + E+
Sbjct: 465 ERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQER-------REQQLRREQEERREQ 517
Query: 446 LLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQK--EEEQLQQARWRAGESEEQRKMRK 503
L++ E+ Q+ Q LR+E Q E RE+ K EE++L+Q R EQ + R
Sbjct: 518 RLKRQEEEERLQQRLRSEQQLRRE-QEERREQLLKREEEKRLEQERREQRLKREQEERRD 576
Query: 504 RILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKE 563
++L + + ++ + + +++ E+ L ++ +LK E+ E+ + + +
Sbjct: 577 QLLKREEERRQQRLKREQEERLEQRLKR-EEVERLEQEERREQRLKREEPEEERRQQLLK 635
Query: 564 AIKKKEQRVQHISQGKDPNFQEFQKLPQASRREER 598
+ +++E+R Q + + + ++ K + R E+
Sbjct: 636 SEEQEERRQQQLRREQQERREQRLKREEEEERLEQ 670
Score = 87.4 bits (215), Expect = 4e-17
Identities = 106/459 (23%), Positives = 202/459 (44%), Gaps = 66/459 (14%)
Query: 198 QKFKRHSACVCAQKRD----SSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVS 253
+KF+ + Q+RD +Q R+ + L +++R + + + E+++
Sbjct: 1414 RKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREE-EQLLQE 1472
Query: 254 SQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQW 313
++QQ L R ++ ++ E +QQ + + D+K RE+ L ++ + ++
Sbjct: 1473 REEQQ-----LHRQERDRKFLEEEQQLRR-----QERDRKF-----REQELRSQEPERKF 1517
Query: 314 QEKE--------QRKTLQSPEQ-----RGLRRDSQRKNVPPGESRWKEQPEDQESPRQEK 360
E+E QRK LQ +Q RG +R R E + +++ E+Q+ RQE+
Sbjct: 1518 LEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQER 1577
Query: 361 LEKARAQAEH-RKQCQVRRLREQEKMLRNLREQHSLQLQR--------RLVEACRKRHLH 411
K R + + R+Q Q R+ E E+ LR Q L+ +R +L++ ++ LH
Sbjct: 1578 DRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLH 1637
Query: 412 AVEGQKKV--QDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKE 469
E +K ++ L Q + D + + EE L Q EQ +R + RK
Sbjct: 1638 RQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERD----RKF 1693
Query: 470 RQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKV 529
R+ E + + Q+ E + Q + E +RK R+ +E++RQ +++
Sbjct: 1694 REEEQQLRRQERERKFLQEEQQLRRQELERKFRE-------EEQLRQETEQEQLRRQERY 1746
Query: 530 QHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKL 589
+ + E LR + + E++ K E E ++++ + Q SQ D F+E ++L
Sbjct: 1747 RKILEEEQLRPEREEQQLRRQERDRKFREE---EQLRQEREEQQLRSQESDRKFREEEQL 1803
Query: 590 PQASRREERAPPNS-------SLDQMVLEAQLRACQQNR 621
Q R E++ P +Q+ LE Q + +Q R
Sbjct: 1804 RQ-EREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQER 1841
Score = 85.1 bits (209), Expect = 2e-16
Identities = 89/407 (21%), Positives = 195/407 (47%), Gaps = 46/407 (11%)
Query: 210 QKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKK 269
++R+ ++ E R+ + + R + L+ +L +QQ+ R ++
Sbjct: 495 ERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRS------EQQL------RREQ 542
Query: 270 AQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRG 329
+R +L ++ + E +R +Q+++ E R LL++ +E+ Q++ +R+ + EQR
Sbjct: 543 EERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRL 602
Query: 330 LRRDSQR-KNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEKMLRN 388
R + +R + E R K E+ E R+++L K+ Q E R+Q Q+RR +++ + R
Sbjct: 603 KREEVERLEQEERREQRLKR--EEPEEERRQQLLKSEEQEERRQQ-QLRREQQERREQRL 659
Query: 389 LREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLR 448
RE+ +L++RL ++ H Q+ ++ + ++R Q ++E R
Sbjct: 660 KREEEEERLEQRL----KREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADAR 715
Query: 449 QLSL-----EQSFQRSQEIHQGLRKERQRELR----EKAQKEEEQLQQAR-----WRAGE 494
Q + +Q QR ++ + R+ R+ EL+ E+A +++++ +Q R W+A E
Sbjct: 716 QSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEE 775
Query: 495 SEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEE 554
E+ + R L +++ RQ R+ + + RE L E+ + + +E
Sbjct: 776 KSERGRQRLSARPPLREQRERQLRA--------EERQQREQRFLPEEEEKEQRRRQRRER 827
Query: 555 KCHIEGIKEAIK-KKEQRVQHISQGKDPNFQEFQ--KLPQASRREER 598
+ ++ ++E + ++ +R Q + + +D QE Q + Q RR+++
Sbjct: 828 EKELQFLEEEEQLQRRERAQQLQEEED-GLQEDQERRRSQEQRRDQK 873
Score = 82.8 bits (203), Expect = 9e-16
Identities = 93/394 (23%), Positives = 180/394 (45%), Gaps = 55/394 (13%)
Query: 268 KKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRK------- 320
++ Q+ +E +++ A+ E+ ++ ++ Q +R L RQ QE WQE+E+R+
Sbjct: 136 RRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQE-WQEREERRAEEEQLQ 194
Query: 321 ------TLQSPEQRGLRR------------DSQRKNVPPGESRWKEQPEDQESPRQEKLE 362
T + P++ LRR + Q++ + ++E+ E + R+ L
Sbjct: 195 SCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLR 254
Query: 363 KARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDT 422
K + + + + R L+E+E+ LR L E+ L+ +R+ E ++R + ++K ++
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKL-ERQELRRERQEEEQQQQRLRREQQLRRKQEEE 313
Query: 423 NLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEI---------HQGLRKERQRE 473
+ ++ + Q + E +QL EQ +R Q++ Q LR+E++ E
Sbjct: 314 RREQQEERREQQERREQQEERRE--QQLRREQEERREQQLRREQEEERREQQLRREQEEE 371
Query: 474 LREKAQKEEEQL---QQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQ 530
RE+ + E+QL QQ R EQ+ R++ L + Q + R++ +
Sbjct: 372 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEE 431
Query: 531 HLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQ--RVQHISQGKDPNFQE-FQ 587
E H +E+ +LK E+EE+ +E ++ EQ R Q + + ++ +E +
Sbjct: 432 ERHEQKHEQERREQ--RLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWL 489
Query: 588 KLPQASRREERAPPNSSLDQMVLEAQLRACQQNR 621
KL + RRE+ Q E QLR Q+ R
Sbjct: 490 KLEEEERREQ---------QERREQQLRREQEER 514
Score = 82.8 bits (203), Expect = 9e-16
Identities = 102/438 (23%), Positives = 207/438 (47%), Gaps = 50/438 (11%)
Query: 217 QVESLASRDSQPLASSKEMRSPHTQVLKSK----LEEVVVSSQDQQIVALVLTRLKKAQR 272
Q E + R Q L++ +R + L+++ E+ + ++++ + ++ +R
Sbjct: 772 QAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEK------EQRRRQRR 825
Query: 273 IRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRK----TLQSPEQR 328
RE + Q + E+L+R ++ Q+ E + L++ QE+ + +EQR+ Q E+R
Sbjct: 826 EREKELQFLEEEEQLQRRERAQQLQEEEDG---LQEDQERRRSQEQRRDQKWRWQLEEER 882
Query: 329 GLRRDSQRKNVPPGESRWKEQ---PEDQESPRQEKLEKARAQAEHRKQCQVRRL-REQEK 384
RR + E KEQ E++E ++E+ EK R Q + R+ + +L +E+E+
Sbjct: 883 KRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQ 942
Query: 385 MLRNLREQHSLQLQRRLVEACRK--RHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAK 442
+LR RE+ Q + R +K + + G++ + Y+ + L Q +
Sbjct: 943 LLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEEL---QQE 999
Query: 443 AEELLRQ-------LSLEQSFQRSQEIHQG----LRKERQR---ELREKAQKEEEQLQQA 488
E+LLR+ E+ +++ E+ Q LR+ER++ + RE+ +EEE+LQQ
Sbjct: 1000 EEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQE 1059
Query: 489 RWR-AGESEEQRKMRK-----RILVELADEKIRQARSHVHKTTR-DKVQHLRELNHLREK 541
+ GE E R+ ++ R EL E+ + R K R ++ + RE L+++
Sbjct: 1060 EEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQE 1119
Query: 542 NHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREERAPP 601
+L+ + EK + +E ++ +Q + + + ++P + Q+L + R EE
Sbjct: 1120 EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR-EEPEKRRRQELERQYREEEELQQ 1178
Query: 602 NSSLDQMVLEAQLRACQQ 619
+Q++ E Q + Q+
Sbjct: 1179 EE--EQLLREEQEKRRQE 1194
Score = 80.5 bits (197), Expect = 4e-15
Identities = 92/407 (22%), Positives = 194/407 (47%), Gaps = 43/407 (10%)
Query: 219 ESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKKAQRIRELQQ 278
+ L ++ Q L E R + K + EE + ++Q L R ++ +R R+ +
Sbjct: 964 KKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQ------LLREEREKRRRQEWE 1017
Query: 279 QAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKN 338
+ + +EL++ ++++ + ERE+R L ++ + Q++E+E+ LQ E++ L + + +
Sbjct: 1018 RQYRKKDELQQEEEQL-LREEREKRRL-QERERQYREEEE---LQQEEEQLLGEERETRR 1072
Query: 339 VPPGESRWKEQPEDQESPRQ---EKLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSL 395
E +++++ E Q+ Q E+ EK R Q E +QC RE+E++ +Q
Sbjct: 1073 RQELERQYRKEEELQQEEEQLLREEPEKRRRQ-ERERQC-----REEEEL-----QQEEE 1121
Query: 396 QLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQS 455
QL R E R++ L +++ L+ + K + +EL RQ E+
Sbjct: 1122 QLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEK------RRRQELERQYREEEE 1175
Query: 456 FQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIR 515
Q+ +E +E++R+ RE+ +EEE+LQ+ ++RK R R + +D K +
Sbjct: 1176 LQQEEEQLLREEQEKRRQERERQYREEEELQR---------QKRKQRYRDEDQRSDLKWQ 1226
Query: 516 QARSHVHKTTRDKVQ-HLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQH 574
+ +KV RE R+ L+ + +++ H+ G ++ ++++R +
Sbjct: 1227 WEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRW 1286
Query: 575 ISQGKDPNFQEFQKLPQASRREERAPPNSSLDQMVLEAQLRACQQNR 621
Q +D +F E ++L + ++E + S ++ L + R ++ R
Sbjct: 1287 --QQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRR 1331
Score = 79.0 bits (193), Expect = 1e-14
Identities = 98/458 (21%), Positives = 192/458 (41%), Gaps = 79/458 (17%)
Query: 219 ESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKKAQRIRELQQ 278
E L + Q L +E R + + EE V ++Q +L + +R +EL++
Sbjct: 1114 EELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQ-----LLREEPEKRRRQELER 1168
Query: 279 QAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPE-QRGLRRDSQRK 337
Q + E L++E LLR+ QE+ +++ +R+ + E QR R+ R
Sbjct: 1169 QYREEEE------------LQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRD 1216
Query: 338 NVPPGESRWKEQPEDQESPRQEKL--------------------EKARAQAEHRKQCQVR 377
+ +W+ +PE + + R K+ +++ +H Q
Sbjct: 1217 EDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQE 1276
Query: 378 RLREQEKMLRNLREQH---SLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARK 434
R REQE+ R++H QL+R + ++R + E ++ +++ + +
Sbjct: 1277 RDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDR 1336
Query: 435 VLMD----CQAKAEELLRQLSLEQSFQRSQEIHQG------------LRKERQR-----E 473
+ Q + E+ LR+ ++ F+ + HQ R+ER+R E
Sbjct: 1337 KFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEE 1396
Query: 474 LREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLR 533
+ + Q+ E+QL+Q R R EEQ+ R+ D K R+ V + R++ + L
Sbjct: 1397 QQLRCQEREQQLRQDRDRKFREEEQQLSRQE-----RDRKFREEEQQVRRQERER-KFLE 1450
Query: 534 ELNHLREKNHHILK-----LKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQK 588
E LR++ H + L+ +E++ H + ++EQ+++ Q +D F+E +
Sbjct: 1451 EEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRR--QERDRKFREQEL 1508
Query: 589 LPQASRR----EERAPPNSSLDQMVLEAQLRACQQNRG 622
Q R EE+ + L+ + + +Q RG
Sbjct: 1509 RSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERG 1546
Score = 72.0 bits (175), Expect = 2e-12
Identities = 100/447 (22%), Positives = 192/447 (42%), Gaps = 66/447 (14%)
Query: 211 KRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQ---DQQIVALVLTRL 267
KR+ +++E R+ Q L + Q+LKS+ +E Q +QQ RL
Sbjct: 603 KREEVERLEQEERRE-QRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ--ERREQRL 659
Query: 268 KKAQRIRELQQQAAKAWEELKRSDQKVQMTLERER-RLLLRQSQEQWQ------------ 314
K+ + L+Q+ + EE +R + + E+ R R+ R + QWQ
Sbjct: 660 KREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKV 719
Query: 315 -----EKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQ------ESPRQEKLEK 363
++E ++ Q E++ RR+S+ + + ++Q E+Q + +EK E+
Sbjct: 720 YSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSER 779
Query: 364 AR----------------AQAEHRKQCQVRRL-------------REQEKMLRNLREQHS 394
R +AE R+Q + R L RE+EK L+ L E+
Sbjct: 780 GRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ 839
Query: 395 LQLQRRLVEACRKRH-LHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLE 453
LQ + R + + L + +++ Q+ +Q + + + + L + +L+
Sbjct: 840 LQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEE---ERKRRRHTLYAKPALQ 896
Query: 454 QSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEK 513
+ ++ Q++ Q +E QRE REK +++E++ Q + EE++ +R+ E+
Sbjct: 897 EQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQER 956
Query: 514 IRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGI--KEAIKKKEQR 571
RQ R K + + Q L E R + K + E+E + E + +E K++ Q
Sbjct: 957 ERQYRKD-KKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQE 1015
Query: 572 VQHISQGKDPNFQEFQKLPQASRREER 598
+ + KD QE ++L + R + R
Sbjct: 1016 WERQYRKKDELQQEEEQLLREEREKRR 1042
Score = 71.6 bits (174), Expect = 2e-12
Identities = 85/343 (24%), Positives = 155/343 (45%), Gaps = 24/343 (6%)
Query: 291 DQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQP 350
D++ + + + LL + QE+ Q + + + Q E+ G RR +R+ + +EQ
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS 155
Query: 351 EDQE----SPRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSL----QLQRR-L 401
E QE RQ + E+ Q + ++ + RR E++ E QL+RR L
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRREL 215
Query: 402 VEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQE 461
+E RK + +++ QD + RK + + EE Q Q + QE
Sbjct: 216 LELRRKGREEKQQQRRERQDRVFQEEEEKEWRK--RETVLRKEEEKLQEEEPQRQRELQE 273
Query: 462 IHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHV 521
+ LRK ++ELR + Q+EE+Q Q+ R ++ R+ ++ E +E+ Q
Sbjct: 274 EEEQLRKLERQELRRERQEEEQQQQRLR----REQQLRRKQEEERREQQEERREQQERRE 329
Query: 522 HKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDP 581
+ R + Q RE RE+ +L+ E+EE+ + ++ +++E+R Q + + +
Sbjct: 330 QQEERREQQLRREQEERREQ-----QLRREQEEERREQQLRRE-QEEERREQQLRREQQL 383
Query: 582 NFQEFQKLPQASRREERAPPNSSL---DQMVLEAQLRACQQNR 621
++ + Q RRE++ L Q+ E QLR QQ R
Sbjct: 384 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 426
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 79.0 bits (193), Expect = 1e-14
Identities = 102/422 (24%), Positives = 204/422 (48%), Gaps = 59/422 (13%)
Query: 205 ACVCAQKRDSSDQVESLAS-RDSQPLA------SSKEMRSPHTQVLKSKLEEVVVSSQDQ 257
+ V QK+ + +E L RD+ L + +E++ + + L+ KL+ V +
Sbjct: 182 SAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAK-LQEKLQLVESEKSEI 240
Query: 258 QIVALVLTR-LKKAQRI---RELQQQAAKAWEELKRSDQKVQMTLERER---RLLLRQSQ 310
Q+ L R L++A+ + ++LQ +A +EL+ K+Q +E RL +Q +
Sbjct: 241 QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEE 300
Query: 311 EQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPED---QESPRQEKLEKARAQ 367
+ W+++E+ + + Q Q + + E + +EQ E QE EK EK R Q
Sbjct: 301 KMWRQEEKIQEWEEKIQE------QEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQ 354
Query: 368 AE--HRKQCQVRRLR----EQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQD 421
E K+ ++RRL E+E+ +R L E+ Q + R E R+ E +K+ +
Sbjct: 355 EEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 414
Query: 422 TNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIH--QGLRKERQRELREKAQ 479
+ + Q K+ + EE +R+ ++ +++ ++IH + +R+E +R+ +E+
Sbjct: 415 ---EAKMWRQEEKI-----REQEEKIREQE-KKMWRQEEKIHEQEKIREEEKRQEQEEMW 465
Query: 480 KEEEQL--QQARWRAGES-EEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELN 536
++EE++ Q+ WR E EQ K+RK+ +EK+ + +H D+ + +RE
Sbjct: 466 RQEEKIREQEEIWRQKEKMHEQEKIRKQ------EEKVWRQEEKMH----DQEEKIREQE 515
Query: 537 HLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRRE 596
+ ++ E+EEK I +E I+++E+ +Q + ++ Q+ + R+E
Sbjct: 516 EKMWRQEEKIR---EQEEK--IREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQE 570
Query: 597 ER 598
E+
Sbjct: 571 EK 572
Score = 75.5 bits (184), Expect = 1e-13
Identities = 80/341 (23%), Positives = 172/341 (50%), Gaps = 36/341 (10%)
Query: 268 KKAQRIRE----LQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQ 323
++ ++IRE +++Q WE+ ++ ++ +M E+E + + R + W+++E+ + L+
Sbjct: 325 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK-MRRLEEMMWEKEEKIRELE 383
Query: 324 SP--EQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLRE 381
EQ + R+ + K + R +E+ ++QE+ + EK R Q E ++ + + R+
Sbjct: 384 EKMHEQEKI-REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQ 442
Query: 382 QEKM--LRNLREQHSLQLQRRLVEACRK-RHLHAVEGQKKVQDTNLSSLINYQARKVLM- 437
+EK+ +RE+ Q Q + K R + QK + + I Q KV
Sbjct: 443 EEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQK--EKMHEQEKIRKQEEKVWRQ 500
Query: 438 -DCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESE 496
+ EE +R+ E+ +++ ++I + ++E+ RE EK +++EE +Q+ + GE E
Sbjct: 501 EEKMHDQEEKIREQE-EKMWRQEEKIRE--QEEKIREQEEKIREQEEMMQEQEEKMGEQE 557
Query: 497 EQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKC 556
E KM+++ + +EKIR+ +K++ +E +RE+ I E+EEK
Sbjct: 558 E--KMQEQEKMRRQEEKIRE--------QEEKIREQKE--KIREQEEKIW----EQEEK- 600
Query: 557 HIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREE 597
I +E ++++E+++ + ++ Q+ + RR+E
Sbjct: 601 -IREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQE 640
Score = 63.5 bits (153), Expect = 5e-10
Identities = 74/373 (19%), Positives = 179/373 (47%), Gaps = 47/373 (12%)
Query: 198 QKFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKS-----KLEEVVV 252
+K + + Q+ +Q E + ++ ++MR + + +LEE++
Sbjct: 314 EKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMW 373
Query: 253 SSQDQQIVALVLTRLKKAQRIRELQ---QQAAKAWEELKRSDQKVQMTLERERRLLLRQS 309
+++ + + ++ + ++IRE + Q+ K E+ KR +Q+ +M + E+ +R+
Sbjct: 374 EKEEK--IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK---IREQ 428
Query: 310 QEQWQEKEQRKTLQSP---EQRGLRRDSQRKNVPPGESRWKEQPE--DQESPRQEKLEKA 364
+E+ +E+E++ Q EQ +R + +R+ E W+++ + +QE ++K EK
Sbjct: 429 EEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQ---EEMWRQEEKIREQEEIWRQK-EKM 484
Query: 365 RAQAEHRKQCQVRRLREQEKML---RNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQD 421
Q + RKQ + + R++EKM +REQ ++ E R++ E ++K+++
Sbjct: 485 HEQEKIRKQ-EEKVWRQEEKMHDQEEKIREQEEKMWRQE--EKIREQEEKIREQEEKIRE 541
Query: 422 TNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQR--------- 472
++ Q K+ + E++ Q + + ++ +E + +R+++++
Sbjct: 542 QE--EMMQEQEEKM----GEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIW 595
Query: 473 ELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHL 532
E EK +++EE +Q+ + E EE+ ++ + E +EK+R+ K +V+
Sbjct: 596 EQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE-QEEKMRRQE---EKMWEQEVRLR 651
Query: 533 RELNHLREKNHHI 545
++ ++E H+
Sbjct: 652 QQEEKMQEHQEHL 664
Score = 55.5 bits (132), Expect = 1e-07
Identities = 66/294 (22%), Positives = 127/294 (43%), Gaps = 41/294 (13%)
Query: 360 KLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLV--------EACRKRHLH 411
+LE+A + +K+ R + E K R+ SL+L R + A + L
Sbjct: 176 ELEQALSAVATQKKKADRYIEELTKE----RDALSLELYRNTITDEELKEKNAKLQEKLQ 231
Query: 412 AVEGQKKVQDTNLSSLINYQARKVLM----DCQAKAEELLRQLS--------------LE 453
VE +K N+ L R L+ QA+A+ L ++L L
Sbjct: 232 LVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELW 291
Query: 454 QSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEK 513
+ QE ++E+ +E EK Q++EE++++ + E EE+ + ++ ++ E ++
Sbjct: 292 NRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKM 351
Query: 514 IRQARSHVHKTTRDKVQHLRE--------LNHLREKNHHILKLKAEKEEKCHIEGIKEAI 565
RQ K +K++ L E + L EK H K++ ++E++ E I+E
Sbjct: 352 RRQEEMMWEK--EEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQE 409
Query: 566 KKKEQRVQHISQGKDPNFQEFQKLPQASRREERAPPNSSLDQMVLEAQLRACQQ 619
K++EQ + Q + QE +K+ + ++ R + + E + R Q+
Sbjct: 410 KRQEQEAKMWRQEEKIREQE-EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQE 462
Score = 50.4 bits (119), Expect = 5e-06
Identities = 45/213 (21%), Positives = 103/213 (48%), Gaps = 13/213 (6%)
Query: 183 WSPSSVPSERSSVPSQKFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRSPHTQV 242
W E+ + ++ ++ + Q+ +Q E R + + +++R +V
Sbjct: 440 WRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIW--RQKEKMHEQEKIRKQEEKV 497
Query: 243 LKSKLEEVVVSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERER 302
+ +E + Q+++I ++ ++IRE +++ + E+++ ++ +Q E+E
Sbjct: 498 WR---QEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQ---EQEE 551
Query: 303 RLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPE--DQESPRQEK 360
++ ++ + Q QEK +R+ + EQ R+ + K E W+++ + +QE QE+
Sbjct: 552 KMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQ 611
Query: 361 LEKARAQAEHRKQC-QVRRLREQEKMLRNLREQ 392
EK Q E K C Q +++EQE+ +R E+
Sbjct: 612 EEKMWEQEE--KMCEQEEKMQEQEEKMRRQEEK 642
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 77.8 bits (190), Expect = 3e-14
Identities = 88/445 (19%), Positives = 208/445 (46%), Gaps = 39/445 (8%)
Query: 188 VPSERSSVPSQKFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKL 247
+P +++ ++ R + Q++ Q E + ++ + +MR Q K +
Sbjct: 224 LPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE---QEEKMRR 280
Query: 248 EEVVVSSQDQQIVALVLTRLKKAQRIRE----LQQQAAKAWEELKRSDQKVQMTLERERR 303
+E + Q++++ L++ +++RE +Q+Q K WE+ ++ ++ + +E R
Sbjct: 281 QEKRLREQEKELREQE-KELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEER 339
Query: 304 LLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEK 363
L ++ Q + QE++ R + ++ R + + + E W+++ + QE R + EK
Sbjct: 340 LWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREK 399
Query: 364 ARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQ-LQRRLVEACRKRHLHAVEGQKKVQDT 422
+ E + Q ++++QE+ N+ EQ + Q+RL E K + Q+K+Q+
Sbjct: 400 KMREEEETMREQEEKMQKQEE---NMWEQEEKEWQQQRLPEQKEK-----LWEQEKMQEQ 451
Query: 423 NLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEE 482
I Q K+ + +E + Q R QE ++E+ R+ +K +E
Sbjct: 452 --EEKIWEQEEKIRDQEEMWGQE---KKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQE 506
Query: 483 EQLQQARWRAGESEEQRKMRKRILVELADEKIRQAR--SHVHKTTRDKVQHLRELNHLRE 540
E++ + R E EE+ + +K++ + +EK+R+ + K T D+ + +RE +RE
Sbjct: 507 ERMWEQDERLREKEERMREQKKMWQQ--EEKMREEKKTQEQEKKTWDQEEKMREEERMRE 564
Query: 541 KNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRR----E 596
+ EK+ + E ++E +K +++ + + + ++ +++ +K+ + + E
Sbjct: 565 R---------EKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQE 615
Query: 597 ERAPPNSSLDQMVLEAQLRACQQNR 621
E+ D+M + ++ Q+ +
Sbjct: 616 EKMWEQEEEDKMQEQEEMMWEQEEK 640
Score = 70.9 bits (172), Expect = 3e-12
Identities = 80/397 (20%), Positives = 186/397 (46%), Gaps = 35/397 (8%)
Query: 210 QKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKK 269
Q+ +Q E + ++ + K+MR Q K + +E + QD+++ +K
Sbjct: 322 QEEKMREQEEKMWRQEERLWEQEKQMRE---QEQKMRDQEERMWEQDERL-------REK 371
Query: 270 AQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQ-R 328
+R+RE + K WE+ ++ ++ ++ RER +R+ +E +E+E++ Q
Sbjct: 372 EERMREQE----KMWEQEEKMQEEERI---REREKKMREEEETMREQEEKMQKQEENMWE 424
Query: 329 GLRRDSQRKNVPPGESR-WK-EQPEDQESPRQEKLEKARAQAE----HRKQCQVRRLREQ 382
++ Q++ +P + + W+ E+ ++QE E+ EK R Q E +K + ++REQ
Sbjct: 425 QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ 484
Query: 383 EKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAK 442
E + E+ Q Q+ + +R E ++ ++ +Q + + + +
Sbjct: 485 EDQMWEQEEKMRDQEQKMWDQ--EERMWEQDERLREKEERMREQKKMWQQEEKMREEKKT 542
Query: 443 AEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMR 502
E+ + E+ + + + + R+++ RE E +++EE++Q+ + E EE+ +
Sbjct: 543 QEQEKKTWDQEEKMREEERMRE--REKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQ 600
Query: 503 KRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKA-EKEEKCHIEGI 561
+ + E ++ Q + DK+Q E+ +E+ + K E+EEK +
Sbjct: 601 EEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQ-- 658
Query: 562 KEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREER 598
+E ++++E+++ QG++ +E ++ Q + R
Sbjct: 659 EEKMREQEEKM----QGQEEKMREQEEKMQGQEEKMR 691
Score = 70.1 bits (170), Expect = 6e-12
Identities = 75/381 (19%), Positives = 170/381 (44%), Gaps = 42/381 (11%)
Query: 217 QVESLASRDSQPLASSKEMRSPHTQVLKS--KLEEVVVSSQDQQIVALVLTRLKKAQRIR 274
Q E L ++ Q ++MR ++ + +L E ++Q+ + ++++ +RIR
Sbjct: 336 QEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIR 395
Query: 275 ELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEK---EQRKTLQSPEQRGLR 331
E +++ + E ++ ++K+Q ++ + Q +++WQ++ EQ++ L E+ +
Sbjct: 396 EREKKMREEEETMREQEEKMQ----KQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ 451
Query: 332 RDS---QRKNVPPGESRW--------KEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLR 380
+ Q + + E W +E+ +QE E+ EK R Q E + Q R+
Sbjct: 452 EEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ-EQKMWDQEERMW 510
Query: 381 EQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQ 440
EQ++ LR E+ Q + E + E +KK D ++ M +
Sbjct: 511 EQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWD-----------QEEKMREE 559
Query: 441 AKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKA--------QKEEEQLQQARWRA 492
+ E +++ E+ R QE ++E+ RE EK ++EE+ +Q
Sbjct: 560 ERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMW 619
Query: 493 GESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEK 552
+ EE + + ++ +EK+++ + + + ++ EK + E+
Sbjct: 620 EQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQ 679
Query: 553 EEKCHIEGIKEAIKKKEQRVQ 573
EEK ++G +E ++++E++++
Sbjct: 680 EEK--MQGQEEKMREQEEKMR 698
Score = 67.0 bits (162), Expect = 5e-11
Identities = 89/403 (22%), Positives = 187/403 (46%), Gaps = 31/403 (7%)
Query: 231 SSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRS 290
S K + + LK KLE Q L ++ + +RE +++ K E++ R
Sbjct: 201 SEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQ 260
Query: 291 DQKVQMTLERERRLLLRQSQEQWQEK---EQRKTLQSPEQRGLRRDSQRKNVPPGESRWK 347
+++++ E+E ++ ++ + + QEK EQ K L+ E+ LR ++K + E + +
Sbjct: 261 EERLR---EQEGKMREQEEKMRRQEKRLREQEKELREQEKE-LR---EQKKLREQEEQMQ 313
Query: 348 EQPE---DQESPRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEA 404
EQ E +QE +E+ EK Q E R Q +++REQE+ +R+ E+ Q +R +
Sbjct: 314 EQEEKMWEQEEKMREQEEKMWRQ-EERLWEQEKQMREQEQKMRDQEERMWEQDERLREKE 372
Query: 405 CRKRHLHAV-EGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSF--QRSQE 461
R R + E ++K+Q+ I + +K+ + + E+ + E++ Q +E
Sbjct: 373 ERMREQEKMWEQEEKMQE---EERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKE 429
Query: 462 IHQGLRKERQREL--REKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARS 519
Q E++ +L +EK Q++EE++ + + + EE K++ EK+R+
Sbjct: 430 WQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKM---WRQEKMREQED 486
Query: 520 HV---HKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHIS 576
+ + RD+ Q + + + L+ EKEE+ + ++K + +
Sbjct: 487 QMWEQEEKMRDQEQKMWDQEERMWEQDERLR---EKEERMREQKKMWQQEEKMREEKKTQ 543
Query: 577 QGKDPNFQEFQKLPQASRREERAPPNSSLDQMVLEAQLRACQQ 619
+ + + + +K+ + R ER ++M+ E + + +Q
Sbjct: 544 EQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQ 586
Score = 63.9 bits (154), Expect = 4e-10
Identities = 72/350 (20%), Positives = 167/350 (47%), Gaps = 36/350 (10%)
Query: 231 SSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKKAQRIREL--QQQAAKAWEELK 288
+++E++ + + L+ KL + S+ +I V +K +R + L Q Q EE+
Sbjct: 181 TNEELKKKNAE-LQEKLR--LAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMW 237
Query: 289 RSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKE 348
R +++ L + + + +Q ++ W+++E+ + EQ G R+ + K + E R +E
Sbjct: 238 RQEEE----LREQEKKIRKQEEKMWRQEERLR-----EQEGKMREQEEK-MRRQEKRLRE 287
Query: 349 QPED-QESPRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACRK 407
Q ++ +E ++ + +K + E + Q Q ++ EQE+ +R +E+ + + RL E ++
Sbjct: 288 QEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMRE-QEEKMWRQEERLWE--QE 344
Query: 408 RHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLR 467
+ + E + + Q+ + ++ + L + + + E + E+ Q + I + +
Sbjct: 345 KQMREQEQKMRDQEERM-----WEQDERLREKEERMREQEKMWEQEEKMQEEERIREREK 399
Query: 468 KERQ-----RELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVH 522
K R+ RE EK QK+EE + W E E Q++ +L +++ Q +
Sbjct: 400 KMREEEETMREQEEKMQKQEENM----WEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI 455
Query: 523 KTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRV 572
+K++ E+ +K K++ ++++ E E ++ +EQ++
Sbjct: 456 WEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQE---EKMRDQEQKM 502
Score = 63.9 bits (154), Expect = 4e-10
Identities = 73/381 (19%), Positives = 174/381 (45%), Gaps = 38/381 (9%)
Query: 191 ERSSVPSQKFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKL-EE 249
ER +K + + Q+ Q E++ ++ KE + K KL E+
Sbjct: 392 ERIREREKKMREEEETMREQEEKMQKQEENMWEQEE------KEWQQQRLPEQKEKLWEQ 445
Query: 250 VVVSSQDQQIVALVLTRLKKAQRIRELQQ---QAAKAWEELKRSDQKVQMTLERERRLLL 306
+ Q+++I ++ ++IR+ ++ Q K W + K +Q+ QM + E+ +
Sbjct: 446 EKMQEQEEKI-------WEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEK--MR 496
Query: 307 RQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARA 366
Q Q+ W ++E+ + R ++K + E + +E+ + QE ++ ++ +
Sbjct: 497 DQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKM 556
Query: 367 QAEHRKQCQVRRLREQEKMLRNLREQHSLQLQR---------RLVEACRKRHLHAVEGQK 417
+ E R + + +++RE+E+M+R E+ Q ++ E +++ E ++
Sbjct: 557 REEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEE 616
Query: 418 KVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREK 477
K+ + + Q +++ + + K +E ++ ++ R QE ++E+ + EK
Sbjct: 617 KMWEQEEEDKMQEQ-EEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEK 675
Query: 478 AQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKI--RQARSHVHKTTRDKVQHLREL 535
+++EE++Q + E EE+ + ++ + +EK+ ++ + + R+K + +R+
Sbjct: 676 MREQEEKMQGQEEKMREQEEKMRGQEEKMWG-QEEKMWGQEEKMWGQEEMREKEERIRD- 733
Query: 536 NHLREKNHHILKLKAEKEEKC 556
+EK L E EE+C
Sbjct: 734 --QKEKMQERL---PEHEERC 749
Score = 61.6 bits (148), Expect = 2e-09
Identities = 77/333 (23%), Positives = 149/333 (44%), Gaps = 38/333 (11%)
Query: 268 KKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQ 327
KK ++E + A E++ + ++++ LER + LL + QE+ R+ + EQ
Sbjct: 187 KKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQ 246
Query: 328 RGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEKMLR 387
R + K R +E+ +QE +E+ EK R Q E R + Q + LREQEK LR
Sbjct: 247 EKKIRKQEEKMW-----RQEERLREQEGKMREQEEKMRRQ-EKRLREQEKELREQEKELR 300
Query: 388 ---NLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAE 444
LREQ E +++ E ++K+++ Q K+ + +
Sbjct: 301 EQKKLREQE---------EQMQEQEEKMWEQEEKMRE---------QEEKMWRQ-EERLW 341
Query: 445 ELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKR 504
E +Q+ ++ R QE + ER RE E+ +++E+ +Q + +E+ ++R+R
Sbjct: 342 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEE----KMQEEERIRER 397
Query: 505 ILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEA 564
++K+R+ + + + + EK +L +KE+ E ++E
Sbjct: 398 ------EKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ 451
Query: 565 IKKKEQRVQHISQGKDPNFQEFQKLPQASRREE 597
+K ++ + I ++ QE + Q RE+
Sbjct: 452 EEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ 484
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 77.8 bits (190), Expect = 3e-14
Identities = 121/554 (21%), Positives = 223/554 (40%), Gaps = 52/554 (9%)
Query: 92 PLERSRKHRPRSRRLEDAWGETGTKPRPAWQPQTQLPPQRPQPCPHYPLAQGDSPPPCPG 151
P E + PRS E+ + G + +P W+ +L Q + P P
Sbjct: 476 PHEERAQSPPRSLATEEEPPQ-GPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPA 534
Query: 152 GAGTPLSGTFRVEKAQGGDQWAV-PLGRHLGRWSPSSVPSERSSVPSQKFKRHSACVCAQ 210
+ E+ G + A P + +P P RS+ P ++ S A
Sbjct: 535 ACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSE---AA 591
Query: 211 KRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKKA 270
+ + V + +D + L SK+ + +L E + ++++I+ L + +
Sbjct: 592 LKAMEEAVAQVLEQDQRHLLESKQEKM-------QQLREKLCQEEEEEILRLHQQKEQSL 644
Query: 271 QRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQS------ 324
+RE Q+A + E R ++ +++ R + Q+ E EQ +LQ
Sbjct: 645 SSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELE 704
Query: 325 PEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEK 384
+Q+ R ++KN E + KE+ E E Q L A+ +A + + Q+ E+++
Sbjct: 705 SQQKAERASLEQKNRQMLE-QLKEEIEASEKSEQAALNAAKEKALQQLREQLEG--ERKE 761
Query: 385 MLRNLREQHSLQLQRRLVEACRKRHLHAVEG-QKKVQDTNLSSLINYQARKVLMDCQAKA 443
+ L ++HS +L+R L + +H V QKK+Q+ + L C +
Sbjct: 762 AVATLEKEHSAELER-LCSSLEAKHREVVSSLQKKIQEAQ------QKEEAQLQKCLGQV 814
Query: 444 EELLRQLSLEQSFQRSQEIHQGLRKERQR-----ELREKAQKEEEQLQQARWRAGESEEQ 498
E + Q S + E+ LR++RQ E R KEE Q A+ R E+
Sbjct: 815 EHRVHQKSYHVAGYE-HELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEE 873
Query: 499 RKMRKRILVELADEKIRQARSH------VHKTTRDKVQHLRELNHLREKNHHILKLKAEK 552
RK R +L L E R R+H V + +++ LR + +E+ L+L E
Sbjct: 874 RKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLET 933
Query: 553 EEK------CHIEGIKEAIKKKEQRVQHISQGKDPNFQE----FQKLPQASRREER-APP 601
K +E +E ++++Q++ + + +E Q+L +A +
Sbjct: 934 RAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQS 993
Query: 602 NSSLDQMVLEAQLR 615
N L +++ E Q R
Sbjct: 994 NQQLREILDELQAR 1007
Score = 49.3 bits (116), Expect = 1e-05
Identities = 80/363 (22%), Positives = 144/363 (39%), Gaps = 67/363 (18%)
Query: 234 EMRSPHTQVLKSKLEEVVVSSQDQQIVAL-----VLTRLKKA--QRIRELQQQAAKAWEE 286
+M+ H QV+ E+ + Q+ L L RL++A + + ++Q+ K E+
Sbjct: 853 KMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLED 912
Query: 287 LKRSD-------QKVQMTLER-----ERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDS 334
L+R Q +++ LE + RL L + QE+ +E+++ L Q L+ +
Sbjct: 913 LRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEE 972
Query: 335 QRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHS 394
+Q E+ + L+ + E + Q R+L+ + ++ +L + S
Sbjct: 973 ATAT--------HQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQV--DLLQAQS 1022
Query: 395 LQLQRRL----VEACRKRHLHAVEGQKKVQDTNLS--------------SLINYQARKVL 436
QLQ+ EA +K+HL + V++ N S SL Q ++V
Sbjct: 1023 QQLQKHFSSLEAEAQKKQHLLR---EVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVS 1079
Query: 437 MDCQAKAEEL-LRQLSLEQSFQRSQEIHQGLRKERQ------RELREKAQKEEEQLQQAR 489
E+L L LS + LR ++ R +R + + Q R
Sbjct: 1080 SSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWR 1139
Query: 490 WRAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLK 549
++E K I + + R ++ K TR HL E+ K H++LK K
Sbjct: 1140 HELASAQEVAKDPPGI------KALEDMRKNLEKETR----HLDEMKSAMRKGHNLLKKK 1189
Query: 550 AEK 552
EK
Sbjct: 1190 EEK 1192
Score = 37.4 bits (85), Expect = 0.042
Identities = 43/212 (20%), Positives = 86/212 (40%), Gaps = 14/212 (6%)
Query: 192 RSSVPSQKFKRHSACVCAQKRD------SSDQVESLASRDSQPLASSKEMRSPHTQVLKS 245
R S+ + + K S+ + K D SS V L S + L S+KE T+ ++
Sbjct: 1067 RKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRR 1126
Query: 246 KLEEVVVSSQ-------DQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTL 298
+ + + Q Q VA +K + +R+ ++ + +E+K + +K L
Sbjct: 1127 RQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLL 1186
Query: 299 ERERRLLLRQSQEQWQEKEQRKTL-QSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPR 357
+++ L + W+E TL SP ++ + D + ES P +E R
Sbjct: 1187 KKKEEKLNQLESSLWEEASDEGTLGGSPTKKAVTFDLSDMDSLSSESSESFSPPHREWWR 1246
Query: 358 QEKLEKARAQAEHRKQCQVRRLREQEKMLRNL 389
Q++++ + + LR+ L ++
Sbjct: 1247 QQRIDSTPSLTSRKIHGLSHSLRQISSQLSSV 1278
>gi|239756174 PREDICTED: hypothetical protein [Homo sapiens]
Length = 625
Score = 77.4 bits (189), Expect = 4e-14
Identities = 72/272 (26%), Positives = 130/272 (47%), Gaps = 4/272 (1%)
Query: 252 VSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQE 311
V +D++I AL+L R ++ + E + A WE + ++ + ERE++ L Q +
Sbjct: 349 VPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRR 408
Query: 312 QW-QEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEH 370
W + E+R+ + E+R R QR+ E R +E E Q R+E+ E+A +
Sbjct: 409 AWAAQVEERRGRRGREEREAARRRQRQ-YERSEERRRELAERQGLLRRERAERAAREDRL 467
Query: 371 RKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINY 430
RK Q + L+++E+ L+ RE+ + R A R + + Q++ ++ + + +
Sbjct: 468 RKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARH 527
Query: 431 QARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQ-LQQAR 489
+A Q + E + SLE S R+QE ++ L R+ E E+ +E L+ AR
Sbjct: 528 EALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESAR 587
Query: 490 WRAGESEEQR-KMRKRILVELADEKIRQARSH 520
A S R K+R+ D +R+A+ H
Sbjct: 588 STARASFHVREKVREETNTRSFDRMVREAQLH 619
Score = 52.0 bits (123), Expect = 2e-06
Identities = 67/273 (24%), Positives = 120/273 (43%), Gaps = 33/273 (12%)
Query: 371 RKQCQVRRLREQEKMLRNLREQHSL---QLQRRLVEACRKRHLHAVEGQKKVQDTNLSSL 427
RK + R QE++L L EQ + Q + + V A ++R E Q+ ++ +
Sbjct: 354 RKIAALMLARHQEELL--LLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWA 411
Query: 428 INYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEI--HQG-LRKER-QRELREKAQKEEE 483
+ R+ + + RQ E+S +R +E+ QG LR+ER +R RE ++ +
Sbjct: 412 AQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQ 471
Query: 484 QLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNH 543
Q Q + R +E R+ ++I E A R + + R+K REL+ H
Sbjct: 472 QEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREK----RELSRAERARH 527
Query: 544 HILKLKAEKEEKCHIEGIKE----------------AIKKKEQRVQHISQGKDPNFQEFQ 587
L ++++ EG++ AI +K +R + +++ + + +
Sbjct: 528 EALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESAR 587
Query: 588 KLPQAS---RREERAPPNS-SLDQMVLEAQLRA 616
+AS R + R N+ S D+MV EAQL A
Sbjct: 588 STARASFHVREKVREETNTRSFDRMVREAQLHA 620
>gi|239750672 PREDICTED: hypothetical protein [Homo sapiens]
Length = 627
Score = 77.4 bits (189), Expect = 4e-14
Identities = 72/272 (26%), Positives = 130/272 (47%), Gaps = 4/272 (1%)
Query: 252 VSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQE 311
V +D++I AL+L R ++ + E + A WE + ++ + ERE++ L Q +
Sbjct: 351 VPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRR 410
Query: 312 QW-QEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEH 370
W + E+R+ + E+R R QR+ E R +E E Q R+E+ E+A +
Sbjct: 411 AWAAQVEERRGRRGREEREAARRRQRQ-YERSEERRRELAERQGLLRRERAERAAREDRL 469
Query: 371 RKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINY 430
RK Q + L+++E+ L+ RE+ + R A R + + Q++ ++ + + +
Sbjct: 470 RKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARH 529
Query: 431 QARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQ-LQQAR 489
+A Q + E + SLE S R+QE ++ L R+ E E+ +E L+ AR
Sbjct: 530 EALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESAR 589
Query: 490 WRAGESEEQR-KMRKRILVELADEKIRQARSH 520
A S R K+R+ D +R+A+ H
Sbjct: 590 STARASFHVREKVREETNTRSFDRMVREAQLH 621
Score = 52.0 bits (123), Expect = 2e-06
Identities = 67/273 (24%), Positives = 120/273 (43%), Gaps = 33/273 (12%)
Query: 371 RKQCQVRRLREQEKMLRNLREQHSL---QLQRRLVEACRKRHLHAVEGQKKVQDTNLSSL 427
RK + R QE++L L EQ + Q + + V A ++R E Q+ ++ +
Sbjct: 356 RKIAALMLARHQEELL--LLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWA 413
Query: 428 INYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEI--HQG-LRKER-QRELREKAQKEEE 483
+ R+ + + RQ E+S +R +E+ QG LR+ER +R RE ++ +
Sbjct: 414 AQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQ 473
Query: 484 QLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNH 543
Q Q + R +E R+ ++I E A R + + R+K REL+ H
Sbjct: 474 QEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREK----RELSRAERARH 529
Query: 544 HILKLKAEKEEKCHIEGIKE----------------AIKKKEQRVQHISQGKDPNFQEFQ 587
L ++++ EG++ AI +K +R + +++ + + +
Sbjct: 530 EALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESAR 589
Query: 588 KLPQAS---RREERAPPNS-SLDQMVLEAQLRA 616
+AS R + R N+ S D+MV EAQL A
Sbjct: 590 STARASFHVREKVREETNTRSFDRMVREAQLHA 622
>gi|239744982 PREDICTED: hypothetical protein [Homo sapiens]
Length = 627
Score = 77.4 bits (189), Expect = 4e-14
Identities = 72/272 (26%), Positives = 130/272 (47%), Gaps = 4/272 (1%)
Query: 252 VSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQE 311
V +D++I AL+L R ++ + E + A WE + ++ + ERE++ L Q +
Sbjct: 351 VPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRR 410
Query: 312 QW-QEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEH 370
W + E+R+ + E+R R QR+ E R +E E Q R+E+ E+A +
Sbjct: 411 AWAAQVEERRGRRGREEREAARRRQRQ-YERSEERRRELAERQGLLRRERAERAAREDRL 469
Query: 371 RKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINY 430
RK Q + L+++E+ L+ RE+ + R A R + + Q++ ++ + + +
Sbjct: 470 RKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARH 529
Query: 431 QARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQ-LQQAR 489
+A Q + E + SLE S R+QE ++ L R+ E E+ +E L+ AR
Sbjct: 530 EALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESAR 589
Query: 490 WRAGESEEQR-KMRKRILVELADEKIRQARSH 520
A S R K+R+ D +R+A+ H
Sbjct: 590 STARASFHVREKVREETNTRSFDRMVREAQLH 621
Score = 52.0 bits (123), Expect = 2e-06
Identities = 67/273 (24%), Positives = 120/273 (43%), Gaps = 33/273 (12%)
Query: 371 RKQCQVRRLREQEKMLRNLREQHSL---QLQRRLVEACRKRHLHAVEGQKKVQDTNLSSL 427
RK + R QE++L L EQ + Q + + V A ++R E Q+ ++ +
Sbjct: 356 RKIAALMLARHQEELL--LLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWA 413
Query: 428 INYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEI--HQG-LRKER-QRELREKAQKEEE 483
+ R+ + + RQ E+S +R +E+ QG LR+ER +R RE ++ +
Sbjct: 414 AQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQ 473
Query: 484 QLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNH 543
Q Q + R +E R+ ++I E A R + + R+K REL+ H
Sbjct: 474 QEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREK----RELSRAERARH 529
Query: 544 HILKLKAEKEEKCHIEGIKE----------------AIKKKEQRVQHISQGKDPNFQEFQ 587
L ++++ EG++ AI +K +R + +++ + + +
Sbjct: 530 EALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESAR 589
Query: 588 KLPQAS---RREERAPPNS-SLDQMVLEAQLRA 616
+AS R + R N+ S D+MV EAQL A
Sbjct: 590 STARASFHVREKVREETNTRSFDRMVREAQLHA 622
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sapiens]
Length = 1293
Score = 75.9 bits (185), Expect = 1e-13
Identities = 74/316 (23%), Positives = 142/316 (44%), Gaps = 57/316 (18%)
Query: 268 KKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQ 327
K Q RE + +A + EE KR ++ L R++ +LR+ QE+ +++ + + L +Q
Sbjct: 730 KLEQERREAEMRAKREEEERKRQEE-----LRRQQEEILRRQQEEERKRREEEELARRKQ 784
Query: 328 RGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQE--KM 385
R + + + R +E+ + QE + E+ R + E RKQ ++ R +E+E K
Sbjct: 785 EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW 844
Query: 386 LRNLRE-QHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAE 444
R E Q L+ R +E R H E +K+ + + Q +K LM + + +
Sbjct: 845 AREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKE-------LEVQRQKELMRQRQQQQ 897
Query: 445 ELLRQLSLEQSFQRSQEIH---------------------------QGLRKERQRELREK 477
E LR+L +Q Q+ ++ Q L +ER+R+LRE+
Sbjct: 898 EALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREE 957
Query: 478 AQKEEEQLQQARWRAGESEEQR----------KMRKRILVELADEKIRQARSHVHKTTRD 527
++++ +L +A + + ++Q+ + L+E+ E+ RQ + K +
Sbjct: 958 QRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQ----MQKQQQQ 1013
Query: 528 KVQHLRELNHLREKNH 543
+ QH ++ N R H
Sbjct: 1014 QQQH-QQPNRARNNTH 1028
Score = 65.9 bits (159), Expect = 1e-10
Identities = 58/295 (19%), Positives = 148/295 (50%), Gaps = 35/295 (11%)
Query: 283 AWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPG 342
A E+L++ ++ LE+ERR +++ + +E+++++ L+ ++ LRR + +
Sbjct: 716 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEE----- 770
Query: 343 ESRWKEQPEDQESPRQEKLEKARAQAEH----RKQCQVRRLREQEKMLRNLREQHSLQLQ 398
+++ E++E R+++ E R Q E R+Q + ++QE+ LR L E+ + +
Sbjct: 771 ----RKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE 826
Query: 399 RR-LVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQ 457
RR E RK+ A + ++ + +A++ L + + + EE +L E+ +
Sbjct: 827 RRKQEELLRKQEEEAAKWAREEE----------EAQRRLEENRLRMEEEAARLRHEEEER 876
Query: 458 RSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQA 517
+ +E L +RQ+EL + Q+++E L++ ++Q++ ++ ++L
Sbjct: 877 KRKE----LEVQRQKELMRQRQQQQEALRRL-------QQQQQQQQLAQMKLPSSSTWGQ 925
Query: 518 RSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRV 572
+S+ L E+ L E+ L+ + ++++ ++ +++ ++++Q++
Sbjct: 926 QSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKL 980
Score = 65.5 bits (158), Expect = 1e-10
Identities = 82/389 (21%), Positives = 171/389 (43%), Gaps = 46/389 (11%)
Query: 266 RLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQ---EKEQRKTL 322
RL + Q + L Q +++ Q Q+ ++++ L Q Q+Q ++ Q +
Sbjct: 603 RLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQTLKM 662
Query: 323 QSPEQRGLRRDSQRKNVPPGESRWKEQPE-----------------DQESP-----RQEK 360
+ +Q + ++ +VP S W+ QP D +P + ++
Sbjct: 663 RISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQ 722
Query: 361 LEKARAQA--EHRKQCQVRRLREQEKMLRN--LREQHSLQLQRRLVEACRKRHLHAVEGQ 416
LEKA+A + R++ ++R RE+E+ R LR Q ++ RR E RKR +
Sbjct: 723 LEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQE-EILRRQQEEERKRREEEELAR 781
Query: 417 KKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELRE 476
+K ++ +L + +++ + Q + EE +Q E++ +R +E + +E +R+ E
Sbjct: 782 RKQEE----ALRRQREQEIALRRQREEEERQQQ---EEALRRLEERRR--EEEERRKQEE 832
Query: 477 KAQKEEEQLQQARWRAGESEEQRKMRK-RILVELADEKIRQARSHVHKTTRDKVQHLREL 535
+K+EE + A+W E E QR++ + R+ +E ++R K +VQ +EL
Sbjct: 833 LLRKQEE--EAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEE-RKRKELEVQRQKEL 889
Query: 536 NHLREKNHHILKLKAEKEEKCHIEGIK---EAIKKKEQRVQHISQGKDPNFQEFQKLPQA 592
R++ L+ +++++ + +K + ++ + E QKL +
Sbjct: 890 MRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEE 949
Query: 593 SRREERAPPNSSLDQMVLEAQLRACQQNR 621
R+ R +++ Q + QQ +
Sbjct: 950 RERQLREEQRRQQRELMKALQQQQQQQQQ 978
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sapiens]
Length = 1320
Score = 75.9 bits (185), Expect = 1e-13
Identities = 74/316 (23%), Positives = 142/316 (44%), Gaps = 57/316 (18%)
Query: 268 KKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQ 327
K Q RE + +A + EE KR ++ L R++ +LR+ QE+ +++ + + L +Q
Sbjct: 757 KLEQERREAEMRAKREEEERKRQEE-----LRRQQEEILRRQQEEERKRREEEELARRKQ 811
Query: 328 RGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQE--KM 385
R + + + R +E+ + QE + E+ R + E RKQ ++ R +E+E K
Sbjct: 812 EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW 871
Query: 386 LRNLRE-QHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAE 444
R E Q L+ R +E R H E +K+ + + Q +K LM + + +
Sbjct: 872 AREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKE-------LEVQRQKELMRQRQQQQ 924
Query: 445 ELLRQLSLEQSFQRSQEIH---------------------------QGLRKERQRELREK 477
E LR+L +Q Q+ ++ Q L +ER+R+LRE+
Sbjct: 925 EALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREE 984
Query: 478 AQKEEEQLQQARWRAGESEEQR----------KMRKRILVELADEKIRQARSHVHKTTRD 527
++++ +L +A + + ++Q+ + L+E+ E+ RQ + K +
Sbjct: 985 QRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQ----MQKQQQQ 1040
Query: 528 KVQHLRELNHLREKNH 543
+ QH ++ N R H
Sbjct: 1041 QQQH-QQPNRARNNTH 1055
Score = 65.9 bits (159), Expect = 1e-10
Identities = 58/295 (19%), Positives = 148/295 (50%), Gaps = 35/295 (11%)
Query: 283 AWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPG 342
A E+L++ ++ LE+ERR +++ + +E+++++ L+ ++ LRR + +
Sbjct: 743 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEE----- 797
Query: 343 ESRWKEQPEDQESPRQEKLEKARAQAEH----RKQCQVRRLREQEKMLRNLREQHSLQLQ 398
+++ E++E R+++ E R Q E R+Q + ++QE+ LR L E+ + +
Sbjct: 798 ----RKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE 853
Query: 399 RR-LVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQ 457
RR E RK+ A + ++ + +A++ L + + + EE +L E+ +
Sbjct: 854 RRKQEELLRKQEEEAAKWAREEE----------EAQRRLEENRLRMEEEAARLRHEEEER 903
Query: 458 RSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQA 517
+ +E L +RQ+EL + Q+++E L++ ++Q++ ++ ++L
Sbjct: 904 KRKE----LEVQRQKELMRQRQQQQEALRRL-------QQQQQQQQLAQMKLPSSSTWGQ 952
Query: 518 RSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRV 572
+S+ L E+ L E+ L+ + ++++ ++ +++ ++++Q++
Sbjct: 953 QSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKL 1007
Score = 65.5 bits (158), Expect = 1e-10
Identities = 82/389 (21%), Positives = 171/389 (43%), Gaps = 46/389 (11%)
Query: 266 RLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQ---EKEQRKTL 322
RL + Q + L Q +++ Q Q+ ++++ L Q Q+Q ++ Q +
Sbjct: 630 RLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQTLKM 689
Query: 323 QSPEQRGLRRDSQRKNVPPGESRWKEQPE-----------------DQESP-----RQEK 360
+ +Q + ++ +VP S W+ QP D +P + ++
Sbjct: 690 RISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQ 749
Query: 361 LEKARAQA--EHRKQCQVRRLREQEKMLRN--LREQHSLQLQRRLVEACRKRHLHAVEGQ 416
LEKA+A + R++ ++R RE+E+ R LR Q ++ RR E RKR +
Sbjct: 750 LEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQE-EILRRQQEEERKRREEEELAR 808
Query: 417 KKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELRE 476
+K ++ +L + +++ + Q + EE +Q E++ +R +E + +E +R+ E
Sbjct: 809 RKQEE----ALRRQREQEIALRRQREEEERQQQ---EEALRRLEERRR--EEEERRKQEE 859
Query: 477 KAQKEEEQLQQARWRAGESEEQRKMRK-RILVELADEKIRQARSHVHKTTRDKVQHLREL 535
+K+EE + A+W E E QR++ + R+ +E ++R K +VQ +EL
Sbjct: 860 LLRKQEE--EAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEE-RKRKELEVQRQKEL 916
Query: 536 NHLREKNHHILKLKAEKEEKCHIEGIK---EAIKKKEQRVQHISQGKDPNFQEFQKLPQA 592
R++ L+ +++++ + +K + ++ + E QKL +
Sbjct: 917 MRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEE 976
Query: 593 SRREERAPPNSSLDQMVLEAQLRACQQNR 621
R+ R +++ Q + QQ +
Sbjct: 977 RERQLREEQRRQQRELMKALQQQQQQQQQ 1005
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
Length = 1299
Score = 75.9 bits (185), Expect = 1e-13
Identities = 74/316 (23%), Positives = 142/316 (44%), Gaps = 57/316 (18%)
Query: 268 KKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQ 327
K Q RE + +A + EE KR ++ L R++ +LR+ QE+ +++ + + L +Q
Sbjct: 736 KLEQERREAEMRAKREEEERKRQEE-----LRRQQEEILRRQQEEERKRREEEELARRKQ 790
Query: 328 RGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQE--KM 385
R + + + R +E+ + QE + E+ R + E RKQ ++ R +E+E K
Sbjct: 791 EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW 850
Query: 386 LRNLRE-QHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAE 444
R E Q L+ R +E R H E +K+ + + Q +K LM + + +
Sbjct: 851 AREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKE-------LEVQRQKELMRQRQQQQ 903
Query: 445 ELLRQLSLEQSFQRSQEIH---------------------------QGLRKERQRELREK 477
E LR+L +Q Q+ ++ Q L +ER+R+LRE+
Sbjct: 904 EALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREE 963
Query: 478 AQKEEEQLQQARWRAGESEEQR----------KMRKRILVELADEKIRQARSHVHKTTRD 527
++++ +L +A + + ++Q+ + L+E+ E+ RQ + K +
Sbjct: 964 QRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQ----MQKQQQQ 1019
Query: 528 KVQHLRELNHLREKNH 543
+ QH ++ N R H
Sbjct: 1020 QQQH-QQPNRARNNTH 1034
Score = 65.9 bits (159), Expect = 1e-10
Identities = 58/295 (19%), Positives = 148/295 (50%), Gaps = 35/295 (11%)
Query: 283 AWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPG 342
A E+L++ ++ LE+ERR +++ + +E+++++ L+ ++ LRR + +
Sbjct: 722 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEE----- 776
Query: 343 ESRWKEQPEDQESPRQEKLEKARAQAEH----RKQCQVRRLREQEKMLRNLREQHSLQLQ 398
+++ E++E R+++ E R Q E R+Q + ++QE+ LR L E+ + +
Sbjct: 777 ----RKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE 832
Query: 399 RR-LVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQ 457
RR E RK+ A + ++ + +A++ L + + + EE +L E+ +
Sbjct: 833 RRKQEELLRKQEEEAAKWAREEE----------EAQRRLEENRLRMEEEAARLRHEEEER 882
Query: 458 RSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQA 517
+ +E L +RQ+EL + Q+++E L++ ++Q++ ++ ++L
Sbjct: 883 KRKE----LEVQRQKELMRQRQQQQEALRRL-------QQQQQQQQLAQMKLPSSSTWGQ 931
Query: 518 RSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRV 572
+S+ L E+ L E+ L+ + ++++ ++ +++ ++++Q++
Sbjct: 932 QSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKL 986
Score = 65.5 bits (158), Expect = 1e-10
Identities = 82/389 (21%), Positives = 171/389 (43%), Gaps = 46/389 (11%)
Query: 266 RLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQ---EKEQRKTL 322
RL + Q + L Q +++ Q Q+ ++++ L Q Q+Q ++ Q +
Sbjct: 609 RLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQTLKM 668
Query: 323 QSPEQRGLRRDSQRKNVPPGESRWKEQPE-----------------DQESP-----RQEK 360
+ +Q + ++ +VP S W+ QP D +P + ++
Sbjct: 669 RISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQ 728
Query: 361 LEKARAQA--EHRKQCQVRRLREQEKMLRN--LREQHSLQLQRRLVEACRKRHLHAVEGQ 416
LEKA+A + R++ ++R RE+E+ R LR Q ++ RR E RKR +
Sbjct: 729 LEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQE-EILRRQQEEERKRREEEELAR 787
Query: 417 KKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELRE 476
+K ++ +L + +++ + Q + EE +Q E++ +R +E + +E +R+ E
Sbjct: 788 RKQEE----ALRRQREQEIALRRQREEEERQQQ---EEALRRLEERRR--EEEERRKQEE 838
Query: 477 KAQKEEEQLQQARWRAGESEEQRKMRK-RILVELADEKIRQARSHVHKTTRDKVQHLREL 535
+K+EE + A+W E E QR++ + R+ +E ++R K +VQ +EL
Sbjct: 839 LLRKQEE--EAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEE-RKRKELEVQRQKEL 895
Query: 536 NHLREKNHHILKLKAEKEEKCHIEGIK---EAIKKKEQRVQHISQGKDPNFQEFQKLPQA 592
R++ L+ +++++ + +K + ++ + E QKL +
Sbjct: 896 MRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEE 955
Query: 593 SRREERAPPNSSLDQMVLEAQLRACQQNR 621
R+ R +++ Q + QQ +
Sbjct: 956 RERQLREEQRRQQRELMKALQQQQQQQQQ 984
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
Length = 1299
Score = 75.9 bits (185), Expect = 1e-13
Identities = 74/316 (23%), Positives = 142/316 (44%), Gaps = 57/316 (18%)
Query: 268 KKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQ 327
K Q RE + +A + EE KR ++ L R++ +LR+ QE+ +++ + + L +Q
Sbjct: 736 KLEQERREAEMRAKREEEERKRQEE-----LRRQQEEILRRQQEEERKRREEEELARRKQ 790
Query: 328 RGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQE--KM 385
R + + + R +E+ + QE + E+ R + E RKQ ++ R +E+E K
Sbjct: 791 EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW 850
Query: 386 LRNLRE-QHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAE 444
R E Q L+ R +E R H E +K+ + + Q +K LM + + +
Sbjct: 851 AREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKE-------LEVQRQKELMRQRQQQQ 903
Query: 445 ELLRQLSLEQSFQRSQEIH---------------------------QGLRKERQRELREK 477
E LR+L +Q Q+ ++ Q L +ER+R+LRE+
Sbjct: 904 EALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREE 963
Query: 478 AQKEEEQLQQARWRAGESEEQR----------KMRKRILVELADEKIRQARSHVHKTTRD 527
++++ +L +A + + ++Q+ + L+E+ E+ RQ + K +
Sbjct: 964 QRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQ----MQKQQQQ 1019
Query: 528 KVQHLRELNHLREKNH 543
+ QH ++ N R H
Sbjct: 1020 QQQH-QQPNRARNNTH 1034
Score = 65.9 bits (159), Expect = 1e-10
Identities = 58/295 (19%), Positives = 148/295 (50%), Gaps = 35/295 (11%)
Query: 283 AWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPG 342
A E+L++ ++ LE+ERR +++ + +E+++++ L+ ++ LRR + +
Sbjct: 722 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEE----- 776
Query: 343 ESRWKEQPEDQESPRQEKLEKARAQAEH----RKQCQVRRLREQEKMLRNLREQHSLQLQ 398
+++ E++E R+++ E R Q E R+Q + ++QE+ LR L E+ + +
Sbjct: 777 ----RKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE 832
Query: 399 RR-LVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQ 457
RR E RK+ A + ++ + +A++ L + + + EE +L E+ +
Sbjct: 833 RRKQEELLRKQEEEAAKWAREEE----------EAQRRLEENRLRMEEEAARLRHEEEER 882
Query: 458 RSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQA 517
+ +E L +RQ+EL + Q+++E L++ ++Q++ ++ ++L
Sbjct: 883 KRKE----LEVQRQKELMRQRQQQQEALRRL-------QQQQQQQQLAQMKLPSSSTWGQ 931
Query: 518 RSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRV 572
+S+ L E+ L E+ L+ + ++++ ++ +++ ++++Q++
Sbjct: 932 QSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKL 986
Score = 65.5 bits (158), Expect = 1e-10
Identities = 82/389 (21%), Positives = 171/389 (43%), Gaps = 46/389 (11%)
Query: 266 RLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQ---EKEQRKTL 322
RL + Q + L Q +++ Q Q+ ++++ L Q Q+Q ++ Q +
Sbjct: 609 RLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQTLKM 668
Query: 323 QSPEQRGLRRDSQRKNVPPGESRWKEQPE-----------------DQESP-----RQEK 360
+ +Q + ++ +VP S W+ QP D +P + ++
Sbjct: 669 RISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQ 728
Query: 361 LEKARAQA--EHRKQCQVRRLREQEKMLRN--LREQHSLQLQRRLVEACRKRHLHAVEGQ 416
LEKA+A + R++ ++R RE+E+ R LR Q ++ RR E RKR +
Sbjct: 729 LEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQE-EILRRQQEEERKRREEEELAR 787
Query: 417 KKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELRE 476
+K ++ +L + +++ + Q + EE +Q E++ +R +E + +E +R+ E
Sbjct: 788 RKQEE----ALRRQREQEIALRRQREEEERQQQ---EEALRRLEERRR--EEEERRKQEE 838
Query: 477 KAQKEEEQLQQARWRAGESEEQRKMRK-RILVELADEKIRQARSHVHKTTRDKVQHLREL 535
+K+EE + A+W E E QR++ + R+ +E ++R K +VQ +EL
Sbjct: 839 LLRKQEE--EAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEE-RKRKELEVQRQKEL 895
Query: 536 NHLREKNHHILKLKAEKEEKCHIEGIK---EAIKKKEQRVQHISQGKDPNFQEFQKLPQA 592
R++ L+ +++++ + +K + ++ + E QKL +
Sbjct: 896 MRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEE 955
Query: 593 SRREERAPPNSSLDQMVLEAQLRACQQNR 621
R+ R +++ Q + QQ +
Sbjct: 956 RERQLREEQRRQQRELMKALQQQQQQQQQ 984
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 75.9 bits (185), Expect = 1e-13
Identities = 100/432 (23%), Positives = 190/432 (43%), Gaps = 59/432 (13%)
Query: 223 SRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKKAQRIRELQQQAAK 282
S++ Q +S H+ VL +L+E +DQ++ + + ++I ELQ+Q
Sbjct: 1601 SQELQAQSSQIHDLESHSTVLARELQE-----RDQEVKS-------QREQIEELQRQKEH 1648
Query: 283 AWEELKRSDQKVQMTLERERRL---------LLRQSQEQWQEKEQRKTLQSPEQRGLRRD 333
++L+R DQ++ + ER + L +L + EQ + + + + QR L ++
Sbjct: 1649 LTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQE 1708
Query: 334 SQRKNVPPGES------------RWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLRE 381
+ P ++ R KE+ + + +L++ + Q E + Q R++ E
Sbjct: 1709 RAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGE 1768
Query: 382 QEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQA 441
+L REQ + LQ++L EA + L Q ++ + + Q + L Q
Sbjct: 1769 TSLLLSQ-REQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQ 1827
Query: 442 KA---EELLR------QLSLEQSFQRSQEIHQGLR--KERQRELREKAQKEEEQLQQARW 490
+A EE ++ Q +LEQ+ +E H L+ KE+ R L E+ E ++Q
Sbjct: 1828 QAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEE 1887
Query: 491 RAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKA 550
G+ + + +++ L+ L + QA+ H +T + L+ L+E++ + L+A
Sbjct: 1888 VLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRA 1947
Query: 551 EKEEKCHIE----GIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREERAPPNSSLD 606
E + H E EA+++ + QGK+ + E +L SR E +
Sbjct: 1948 ESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAEL---SRSLEAS------- 1997
Query: 607 QMVLEAQLRACQ 618
L+A L ACQ
Sbjct: 1998 TATLQASLDACQ 2009
Score = 66.2 bits (160), Expect = 8e-11
Identities = 91/401 (22%), Positives = 175/401 (43%), Gaps = 36/401 (8%)
Query: 224 RDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKKAQRIRELQ-QQAAK 282
RD Q LA + S ++L+S L E + Q ++ + +L E+Q Q +
Sbjct: 750 RDRQDLAEQLQGLSSAKELLESSLFE---AQQQNSVIEVTKGQL-------EVQIQTVTQ 799
Query: 283 AWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPG 342
A E ++ + +++ L+ ER SQ + + + L EQ G Q+K
Sbjct: 800 AKEVIQGEVRCLKLELDTER------SQAEQERDAAARQLAQAEQEGKTALEQQKAAHEK 853
Query: 343 E-SRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRL 401
E ++ +E+ E + S Q++L KA E K RL+EQ+ E ++Q QR
Sbjct: 854 EVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQ------TEMEAIQAQREE 907
Query: 402 VEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQ-SFQRSQ 460
+ L ++ + + + +L + Q +K L D + E L + + +++ Q +
Sbjct: 908 ERTQAESALCQMQLETEKERVSLLETL-LQTQKELADASQQLERLRQDMKVQKLKEQETT 966
Query: 461 EIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSH 520
I Q +E QREL+E A++ + L + + + + ++ + +L + + Q S
Sbjct: 967 GILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQ 1026
Query: 521 --VHKTTRDKVQHLRELNHL-----REKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQ 573
V + ++K++ +E N + REK L L EKE++ + ++EA ++Q +
Sbjct: 1027 RLVEQEVQEKLRETQEYNRIQKELEREKASLTLSL-MEKEQRLLV--LQEADSIRQQELS 1083
Query: 574 HISQGKDPNFQEFQKLPQASRREERAPPNSSLDQMVLEAQL 614
+ Q E ++L + D + EAQL
Sbjct: 1084 ALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL 1124
Score = 62.0 bits (149), Expect = 2e-09
Identities = 89/382 (23%), Positives = 158/382 (41%), Gaps = 64/382 (16%)
Query: 220 SLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKKAQRIRELQ-- 277
+LA RD + A +E + Q EE V D AL + +R ELQ
Sbjct: 1811 ALAQRDQELEALQQEQQQAQGQ------EERVKEKADALQGALEQAHMTLKERHGELQDH 1864
Query: 278 -QQAAKAWEELKRSDQKVQM-----------TLERERRLLLRQSQ--EQWQEKE-QRKTL 322
+QA + EEL ++VQ + E+E+ LL Q Q EQ QE E + + L
Sbjct: 1865 KEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRAL 1924
Query: 323 QSP---EQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRL 379
Q Q L+ Q ES+ E+ R E L++A +A Q + + L
Sbjct: 1925 QDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHL 1984
Query: 380 REQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDC 439
EQ ++ R+L E + LQ L +AC+ H +E ++Q+ +
Sbjct: 1985 LEQAELSRSL-EASTATLQASL-DACQA-HSRQLEEALRIQEGEIQ-------------- 2027
Query: 440 QAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQR 499
+Q + +++ Q + QR+ + Q+E EQL + E
Sbjct: 2028 -------------DQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMI 2074
Query: 500 KMRKRILVELADEKIR---QARSHVHKTTRDKVQHLRELNHLREKNH-----HILKLKAE 551
+ ++ + E +E+IR Q+ + T K Q + EL +++N+ H K
Sbjct: 2075 QEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPM 2134
Query: 552 KEEKCHIEGIKEAIKKKEQRVQ 573
+E+ ++ ++ ++++ +R+Q
Sbjct: 2135 EEQSLKLDSLEPRLQRELERLQ 2156
Score = 52.4 bits (124), Expect = 1e-06
Identities = 87/430 (20%), Positives = 188/430 (43%), Gaps = 35/430 (8%)
Query: 170 DQWAVPLGRHLGRWSPSSVPSERSSVPSQKFKRHSACVCAQKRDSSDQVESLASRDSQPL 229
D W R + R + + ++K + H+ Q++ S +Q E Q
Sbjct: 1251 DLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNS 1310
Query: 230 ASSKEMRSPHTQV-LKSKLEEVVVSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELK 288
S+ M T L+S+L + + Q +L K+ + QAA +
Sbjct: 1311 LESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQ 1370
Query: 289 RSDQKV-QMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWK 347
S + + L R L +++E E+E+ + LQ ++G + +Q K + +
Sbjct: 1371 ASAAGILEEDLRTARSALKLKNEEVESERERAQALQ---EQGELKVAQGKALQENLALLT 1427
Query: 348 EQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEA-CR 406
+ + R+E++E R Q ++ L +Q +M + E SL L++R E +
Sbjct: 1428 QTLAE----REEEVETLRGQ--------IQELEKQREMQKAALELLSLDLKKRNQEVDLQ 1475
Query: 407 KRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGL 466
+ + +E + V + +L + + +K+ + E +R+L ++ QR+ HQ L
Sbjct: 1476 QEQIQELEKCRSVLE-HLPMAVQEREQKLTVQ-----REQIRELEKDRETQRNVLEHQLL 1529
Query: 467 RKERQREL----REKAQKEEEQLQQARWRAGESEE---QRKMRKRILVELADEKIRQ--A 517
E++ ++ R + Q ++QL A E EE + + +++++ EL ++ Q A
Sbjct: 1530 ELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVA 1589
Query: 518 RSHVHKTTRDKVQHLR-ELNHLREKNHHILKLKAEKEEK-CHIEGIKEAIKKKEQRVQHI 575
+H+ ++ Q L+ + + + + H L E +E+ ++ +E I++ +++ +H+
Sbjct: 1590 LTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHL 1649
Query: 576 SQGKDPNFQE 585
+Q + QE
Sbjct: 1650 TQDLERRDQE 1659
Score = 35.8 bits (81), Expect = 0.12
Identities = 80/387 (20%), Positives = 143/387 (36%), Gaps = 91/387 (23%)
Query: 304 LLLRQSQEQWQEKEQR--KTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKL 361
LLL ++QE +E +R + +Q Q L + + V + + + E EK+
Sbjct: 248 LLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNED--YEKM 305
Query: 362 EKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQ- 420
KA + + L E E L ++ L LQ+ + + + + EG Q
Sbjct: 306 IKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQ---VMVEEGDNIAQG 362
Query: 421 ---------DTNLSSLINYQ--------ARKVLMDCQAKAEELLRQLS--------LEQS 455
D+++ S +YQ R VL + ++L +QL+ L+Q
Sbjct: 363 SGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQ 422
Query: 456 FQRSQEIHQGLRKE--------------------------RQRELREKAQKEEEQ----L 485
+ +E + LR+ ++REL +KA++E Q L
Sbjct: 423 HDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVL 482
Query: 486 QQARWRAGESEEQRKMRKRILVEL------ADEKIRQARSHVHKTTRDKVQHLRELNHLR 539
+Q WR +R+ VEL A + + + +H R++ + L L
Sbjct: 483 EQEAWRL----------RRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLE 532
Query: 540 EKNHHILK---LKAEKEEKCHIEG---------IKEAIKKKEQRVQHISQGKDPNFQEFQ 587
K L E E H+EG + A+ + EQ + +S ++ E
Sbjct: 533 AKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVA 592
Query: 588 KLPQASRREERAPPNSSLDQMVLEAQL 614
L A+ + +LD++ L QL
Sbjct: 593 DLRAAAVKLSALNEALALDKVGLNQQL 619
Score = 32.0 bits (71), Expect = 1.7
Identities = 84/390 (21%), Positives = 155/390 (39%), Gaps = 74/390 (18%)
Query: 234 EMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSD-- 291
E RSP +K + ++V+ ++Q++AL +++ + A +W +LK S
Sbjct: 2 ETRSPGLNNMKPQSLQLVL---EEQVLALQ----------QQMAENQAASWRKLKNSQEA 48
Query: 292 QKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWK--EQ 349
Q+ Q TL R+ + + Q + QE E+R E G P RW+ E+
Sbjct: 49 QQRQATLVRKLQAKVLQYRSWCQELEKRL-----EATG----------GPIPQRWENVEE 93
Query: 350 PEDQESPRQEKLEKARAQAEHRKQCQVRRLREQ----EKMLRNLREQHSLQLQRRLVEAC 405
P E + + E+ R ++ Q+R E+ K LR E+ ++ R E
Sbjct: 94 PNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELM 153
Query: 406 RKRHLHAVE-----GQKKVQDTNLSSLIN--YQARKVLMDCQAKAEELLRQLSLE----- 453
RK +E G K + L SL R+ ++ ++ + L +L E
Sbjct: 154 RKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLS 213
Query: 454 --------------QSFQRSQEIHQGLRKERQ--------RELREKAQKEEEQLQQARWR 491
QS + + R+ Q +EL ++A + ++L Q + +
Sbjct: 214 GSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQ 273
Query: 492 AGESEEQRKMRKRILVELADEKIRQARSH--VHKTTRDKVQHLRELNHLREKNHHILKLK 549
+ + + R L L + +Q + + K R+ V+ L E NH H +
Sbjct: 274 GDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEIL-ETNHTELMEHEASLSR 332
Query: 550 AEKEEKCHIEG-IKEAIKKKEQRVQHISQG 578
+EEK ++ IK+ + + +I+QG
Sbjct: 333 NAQEEKLSLQQVIKDITQVMVEEGDNIAQG 362
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 75.1 bits (183), Expect = 2e-13
Identities = 70/319 (21%), Positives = 162/319 (50%), Gaps = 24/319 (7%)
Query: 268 KKAQRIRE----LQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQ 323
++ ++IRE +++Q WE+ ++ ++ +M E+E + + RQ + W+++E+ + L+
Sbjct: 386 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK-MRRQEEMMWEKEEKIRELE 444
Query: 324 SP--EQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLRE 381
EQ + R+ + K + R +E+ ++QE+ + EK R Q E ++ + + R+
Sbjct: 445 EKMHEQEKI-REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQ 503
Query: 382 QEKM--LRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLM-- 437
+EK+ +RE+ Q Q + K ++K + I Q K+
Sbjct: 504 EEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQE 563
Query: 438 DCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEE 497
+ EE +R+ E+ +++ ++I + ++E+ RE EK +++EE Q+ + GE EE
Sbjct: 564 EKMHDQEEKIREQE-EKVWRQEEKIRE--QEEKIREQEEKIREQEEMTQEQEEKMGEQEE 620
Query: 498 QRKMRKRILVELADEKIRQARSHV---HKTTRDKVQHLRELNHLREKNHHILKLKAEKEE 554
+ ++ + E +EK+R+ + K R++ + +RE + ++ K+ ++E+
Sbjct: 621 KMCEQEEKMQE-QEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEE--KMWEQEEK 677
Query: 555 KCHIEGIKEAIKKKEQRVQ 573
C E E ++++E++++
Sbjct: 678 MCEQE---EKMQEQEEKMR 693
Score = 73.2 bits (178), Expect = 7e-13
Identities = 101/426 (23%), Positives = 204/426 (47%), Gaps = 61/426 (14%)
Query: 205 ACVCAQKRDSSDQVESLAS-RDSQPLA------SSKEMRSPHTQVLKSKLEEVVVSSQDQ 257
+ V QK+ + +E L RD+ L + +E++ + + L+ KL+ V +
Sbjct: 243 SAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAK-LQEKLQLVESEKSEI 301
Query: 258 QIVALVLTR-LKKAQRI---RELQQQAAKAWEELKRSDQKVQMTLERER---RLLLRQSQ 310
Q+ L R L++A+ + ++LQ +A +EL+ K+Q +E RL +Q +
Sbjct: 302 QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEE 361
Query: 311 EQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPED---QESPRQEKLEKARAQ 367
+ W+++E+ + + Q Q + + E + +EQ E QE EK EK R Q
Sbjct: 362 KMWRQEEKIQEWEEKIQE------QEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQ 415
Query: 368 AE--HRKQCQVRR----LREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQD 421
E K+ ++RR + E+E+ +R L E+ Q + R E R+ E +K+ +
Sbjct: 416 EEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 475
Query: 422 TNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIH--QGLRKERQRELREKAQ 479
+ + Q K+ + EE +R+ E+ +++ ++IH + +R+E +R+ +E+
Sbjct: 476 ---EAKMWRQEEKI-----REQEEKIREQE-EKMWRQEEKIHEQEKIREEEKRQEQEEMW 526
Query: 480 KEEEQL--QQARWRAGES--EEQRKMRKRILVELADEKIRQARSHVH----KTTRDKVQH 531
++EE++ Q+ WR E E++ K+RK+ +EK+ + +H K + +
Sbjct: 527 RQEEKIREQEEIWRQKEKIHEQEEKIRKQ------EEKMWRQEEKMHDQEEKIREQEEKV 580
Query: 532 LRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQ 591
R+ +RE+ I E+EEK I +E +++E+++ + ++ Q+ +
Sbjct: 581 WRQEEKIREQEEKI----REQEEK--IREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEE 634
Query: 592 ASRREE 597
RR+E
Sbjct: 635 KMRRQE 640
Score = 69.3 bits (168), Expect = 1e-11
Identities = 68/320 (21%), Positives = 152/320 (47%), Gaps = 29/320 (9%)
Query: 271 QRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRGL 330
++ ++++Q WE+ ++ ++ +M E+E ++ + + QEK + + + E+ +
Sbjct: 407 EKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI 466
Query: 331 RRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEH-RKQCQVR---RLREQEKML 386
R +R+ R +E+ +QE +E+ EK Q E +Q ++R + +EQE+M
Sbjct: 467 REQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMW 526
Query: 387 RN---LREQHSLQLQRRLV----EACRKRHLHAVEGQKKVQDTNLSSLINYQARKV---- 435
R +REQ + Q+ + E RK+ ++K+ D I Q KV
Sbjct: 527 RQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQE--EKIREQEEKVWRQE 584
Query: 436 --LMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAG 493
+ + + K E ++ ++ + QE G ++E+ E EK Q++EE++++ +
Sbjct: 585 EKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIR 644
Query: 494 ESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKE 553
E E +K+R++ +EKIR+ + + + ++ EK + +E
Sbjct: 645 EQE--KKIREQ------EEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQE 696
Query: 554 EKCHIEGIKEAIKKKEQRVQ 573
EK + ++ ++++E+++Q
Sbjct: 697 EKMWEQEVR--LRQQEEKMQ 714
Score = 66.2 bits (160), Expect = 8e-11
Identities = 76/364 (20%), Positives = 175/364 (48%), Gaps = 34/364 (9%)
Query: 198 QKFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRSPHTQVL----KSKLEEVVVS 253
+K + + Q+ +Q E + ++ ++MR + K + +E ++
Sbjct: 375 EKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMW 434
Query: 254 SQDQQIVALVLTRLKKAQRIRELQ---QQAAKAWEELKRSDQKVQMTLERERRLLLRQSQ 310
++++I L ++ + ++IRE + Q+ K E+ KR +Q+ +M + E+ +R+ +
Sbjct: 435 EKEEKIRELE-EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK---IREQE 490
Query: 311 EQWQEKEQRKTLQSP---EQRGLRRDSQRKNVPPGESRWKEQPE--DQESPRQEKLEKAR 365
E+ +E+E++ Q EQ +R + +R+ E W+++ + +QE ++K EK
Sbjct: 491 EKIREQEEKMWRQEEKIHEQEKIREEEKRQEQ---EEMWRQEEKIREQEEIWRQK-EKIH 546
Query: 366 AQAEHRKQCQVRRLREQEKML---RNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDT 422
Q E ++ + + R++EKM +REQ ++ E R++ E ++K+++
Sbjct: 547 EQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQE--EKIREQEEKIREQEEKIREQ 604
Query: 423 NLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQE-IHQGLRKERQRELREKAQKE 481
+ Q K+ + E+ + E+ +R +E I + +K R++E EK +++
Sbjct: 605 E--EMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQE--EKIREQ 660
Query: 482 EEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREK 541
EE +Q+ + E EE+ ++ + E +EK+R+ K +V+ ++ ++E
Sbjct: 661 EEMMQEQEEKMWEQEEKMCEQEEKMQE-QEEKMRRQE---EKMWEQEVRLRQQEEKMQEH 716
Query: 542 NHHI 545
H+
Sbjct: 717 QEHL 720
Score = 53.1 bits (126), Expect = 7e-07
Identities = 64/292 (21%), Positives = 124/292 (42%), Gaps = 37/292 (12%)
Query: 360 KLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLV--------EACRKRHLH 411
+LE+A + +K+ R + E K R+ SL+L R + A + L
Sbjct: 237 ELEQALSAVATQKKKADRYIEELTKE----RDALSLELYRNTITDEELKEKNAKLQEKLQ 292
Query: 412 AVEGQKKVQDTNLSSLINYQARKVLM----DCQAKAEELLRQLS--------------LE 453
VE +K N+ L R L+ QA+A+ L ++L L
Sbjct: 293 LVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELW 352
Query: 454 QSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEK 513
+ QE ++E+ +E EK Q++EE++++ + E EE+ + ++ ++ E ++
Sbjct: 353 NRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKM 412
Query: 514 IRQARSHVHKTTRDKVQH------LRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKK 567
RQ K + + Q ++ L EK H K++ ++E++ E I+E K+
Sbjct: 413 RRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR 472
Query: 568 KEQRVQHISQGKDPNFQEFQKLPQASRREERAPPNSSLDQMVLEAQLRACQQ 619
+EQ + Q + QE +K+ + + R + + E + R Q+
Sbjct: 473 QEQEAKMWRQEEKIREQE-EKIREQEEKMWRQEEKIHEQEKIREEEKRQEQE 523
Score = 46.6 bits (109), Expect = 7e-05
Identities = 46/202 (22%), Positives = 98/202 (48%), Gaps = 27/202 (13%)
Query: 210 QKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKK 269
QK +Q E + ++ + ++M H Q K + +E V Q+++I ++
Sbjct: 541 QKEKIHEQEEKIRKQEEKMWRQEEKM---HDQEEKIREQEEKVWRQEEKI-------REQ 590
Query: 270 AQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRG 329
++IRE +++ + E + ++K+ E+E ++ + +E+ QE+E++ Q + R
Sbjct: 591 EEKIREQEEKIREQEEMTQEQEEKMG---EQEEKMC--EQEEKMQEQEEKMRRQEEKIR- 644
Query: 330 LRRDSQRKNVPPGESRWKEQPE---DQESPRQEKLEKARAQAEHRKQCQVRRLREQEKM- 385
Q K + E + +EQ E +QE E+ EK Q E ++ + + R++EKM
Sbjct: 645 ----EQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMW 700
Query: 386 ---LRNLREQHSLQLQRRLVEA 404
+R +++ +Q + +EA
Sbjct: 701 EQEVRLRQQEEKMQEHQEHLEA 722
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 74.7 bits (182), Expect = 2e-13
Identities = 109/510 (21%), Positives = 219/510 (42%), Gaps = 66/510 (12%)
Query: 151 GGAGTPLSGTFRVEKAQGGDQWAVPLGRHLGRWSPSSVPSERSSVPSQ---------KFK 201
G GTP S + +A G LG S S +P E + + + +
Sbjct: 131 GNLGTPSSFNLALSQAFRGSP--------LGCVSTSLIPGESKDLAGRLHHSWHFAGELQ 182
Query: 202 RHSACVCAQKRDSSDQVESLAS-RDSQPLA------SSKEMRSPHTQVLKSKLEEVVVSS 254
R + V + + + +E L RD+ L +++E++ + + L+ KL + S
Sbjct: 183 RALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAE-LQEKLP--LAES 239
Query: 255 QDQQIVALVLTRLKKAQRIREL--QQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQ 312
+ +I V +K +R + L Q Q EE+ R +++ L + + + +Q ++
Sbjct: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEE----LREQEKKIRKQEEKM 295
Query: 313 WQE----KEQRKTLQSPEQRGLRRD----SQRKNVPPGESRWKEQPE--DQESPRQEKLE 362
W++ +EQ ++ E++ R++ Q K + E +EQ E +QE QE+ E
Sbjct: 296 WRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEE 355
Query: 363 KARAQAEHRKQ------CQVRRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQ 416
K Q E ++ Q RL EQEK +R +EQ + R+ E + L E +
Sbjct: 356 KMWEQEEKMREQEEKMWRQEERLWEQEKQMRE-QEQKMRDQEERMWE--QDERLREKEER 412
Query: 417 KKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELRE 476
+ Q+ + + K + + + K + ++ E+ R +E +E RE E
Sbjct: 413 MREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERI-REREKKMREEEETMREQEE 471
Query: 477 KAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELN 536
K QK+EE + W E E Q++ +L +++ Q + +K++ E+
Sbjct: 472 KMQKQEENM----WEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMW 527
Query: 537 HLREKNHHILKLKA------EKEEKCHIEGIKEAIKKKEQRVQHISQGKD-PNFQEFQKL 589
+K K++ E+EEK + ++ + +E+R++ +Q ++ + + +K+
Sbjct: 528 GQEKKMWRQEKMREQEDQMWEQEEKMRDQ--EQKMWDQEERMEKKTQEQEKKTWDQEEKM 585
Query: 590 PQASRREERAPPNSSLDQMVLEAQLRACQQ 619
+ R ER ++M+ E + + +Q
Sbjct: 586 REEERMREREKKMREEEEMMREQEEKMQEQ 615
Score = 73.2 bits (178), Expect = 7e-13
Identities = 80/418 (19%), Positives = 192/418 (45%), Gaps = 46/418 (11%)
Query: 210 QKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKK 269
Q+ +Q E + ++ + K+MR Q K + +E + QD+++ +K
Sbjct: 360 QEEKMREQEEKMWRQEERLWEQEKQMRE---QEQKMRDQEERMWEQDERL-------REK 409
Query: 270 AQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRG 329
+R+RE + K WE++++ ++ +M E+E++ ++ + Q +E+ + + + E+
Sbjct: 410 EERMREQE----KMWEQVEKMREEKKMQ-EQEKKTRDQEEKMQEEERIREREKKMREEEE 464
Query: 330 LRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNL 389
R+ + K E+ W+++ ++ + R + +K + + + Q Q ++ EQE+ +R+
Sbjct: 465 TMREQEEKMQKQEENMWEQEEKEWQQQRLPE-QKEKLWEQEKMQEQEEKIWEQEEKIRDQ 523
Query: 390 REQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQ 449
E + + E R++ E ++K++D Q +K+ EE + +
Sbjct: 524 EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRD---------QEQKMW-----DQEERMEK 569
Query: 450 LSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVEL 509
+ EQ + + + +ER RE +K ++EEE +++ + E EE KM+++
Sbjct: 570 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEE--KMQEQ----- 622
Query: 510 ADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKE 569
+EK+ + + + + ++ EK +L +KE+ E ++E K +E
Sbjct: 623 -EEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQE 681
Query: 570 Q--------RVQHISQGKDPNFQEFQKLPQASRREERAPPNSSLDQMVLEAQLRACQQ 619
Q +++ +Q ++ + +K+ + ER ++M+ E + + +Q
Sbjct: 682 QEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQ 739
Score = 72.8 bits (177), Expect = 9e-13
Identities = 78/440 (17%), Positives = 199/440 (45%), Gaps = 48/440 (10%)
Query: 188 VPSERSSVPSQKFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKS-- 245
+P +++ ++ R + Q++ Q E + ++ + +MR ++ +
Sbjct: 262 LPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEK 321
Query: 246 KLEEVVVSSQDQQIVALVLTRLKKAQRIRE----LQQQAAKAWEELKRSDQKVQMTLERE 301
+L E ++Q+ L++ + +RE +Q+Q K WE+ ++ ++ + +E
Sbjct: 322 RLREQEKELREQE------KELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQE 375
Query: 302 RRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKL 361
RL ++ Q + QE++ R + ++ R + + + E W++ + +E + ++
Sbjct: 376 ERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQ 435
Query: 362 EKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQD 421
EK E + Q + R+RE+EK +R E R E +K+ + E ++K
Sbjct: 436 EKKTRDQEEKMQ-EEERIREREKKMREEEE-----TMREQEEKMQKQEENMWEQEEK--- 486
Query: 422 TNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKE 481
+Q +++ + E+L Q +++ ++ E + +R + + +EK
Sbjct: 487 -------EWQQQRL----PEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWR 535
Query: 482 EEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREK 541
+E++++ + E EE+ + +++ + + +E++ + K T D+ + +RE +RE+
Sbjct: 536 QEKMREQEDQMWEQEEKMRDQEQKMWD-QEERMEKKTQEQEKKTWDQEEKMREEERMRER 594
Query: 542 NHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREERAPP 601
K +EE+ + +E ++++E+++Q QE + Q + +E+
Sbjct: 595 E------KKMREEEEMMREQEEKMQEQEEKMQE---------QEEKMWEQEEKMQEQEEK 639
Query: 602 NSSLDQMVLEAQLRACQQNR 621
++ + E + + +Q R
Sbjct: 640 MWEQEEKMWEQEEKMWEQQR 659
Score = 70.9 bits (172), Expect = 3e-12
Identities = 70/364 (19%), Positives = 166/364 (45%), Gaps = 16/364 (4%)
Query: 210 QKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKK 269
Q+ + +Q E + P K Q + K+ E +DQ+ + ++ +
Sbjct: 476 QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWR 535
Query: 270 AQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRG 329
+++RE + Q + E+++ +QK+ ER + Q ++ W ++E+ + E+R
Sbjct: 536 QEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMR----EEERM 591
Query: 330 LRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNL 389
R+ + + +E+ ++QE QE+ EK Q E ++ + + ++EKM
Sbjct: 592 REREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKM---W 648
Query: 390 REQHSLQLQRRLVEACRKRHLH-AVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLR 448
++ + Q+RL E K H ++ Q+K+Q+ + K + + K + +
Sbjct: 649 EQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWD--Q 706
Query: 449 QLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVE 508
+ E+ R +E +E RE EK Q++EE++Q+ E EE+ ++ + E
Sbjct: 707 EKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWE 766
Query: 509 LADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKK 568
++ + H+ +++ + + +R++ K++ ++E+ + G +E ++ +
Sbjct: 767 QQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEE---KMRGQEEK---MRGQEEKMRGQ 820
Query: 569 EQRV 572
E+++
Sbjct: 821 EEKM 824
Score = 54.3 bits (129), Expect = 3e-07
Identities = 57/314 (18%), Positives = 142/314 (45%), Gaps = 24/314 (7%)
Query: 210 QKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKS--KLEEVVVSSQDQQIVALVLTRL 267
Q++ + DQ E + + K+MR + + K++E Q+Q+
Sbjct: 574 QEKKTWDQEEKMREEERMR-EREKKMREEEEMMREQEEKMQEQEEKMQEQEE-------- 624
Query: 268 KKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEK--EQRKTLQSP 325
K ++ ++Q+Q K WE+ ++ ++ + E++R L Q ++ W+ + ++++ +Q
Sbjct: 625 KMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQR--LPEQKEKLWEHEKMQEQEKMQEQ 682
Query: 326 EQRGLRRDSQRKNVPPGESR-WKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEK 384
E++ ++ K E + W ++ +E +E+ +K R + E ++ Q +++EQE+
Sbjct: 683 EEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMRE-QEEKMQEQEE 741
Query: 385 MLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAE 444
++ E+ Q ++ + + + QK+ L Q ++ + + + K
Sbjct: 742 KMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKE----KLWEHEKMQEQEKIWEQEEKMR 797
Query: 445 ELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQL---QQARWRAGESEEQRKM 501
+ ++ ++ R QE ++E+ EK +EE++ ++ W E E++
Sbjct: 798 DQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQ 857
Query: 502 RKRILVELADEKIR 515
+ + +EK+R
Sbjct: 858 GQEEKMREQEEKMR 871
Score = 49.3 bits (116), Expect = 1e-05
Identities = 47/252 (18%), Positives = 115/252 (45%), Gaps = 21/252 (8%)
Query: 268 KKAQRIRELQQQAAKAWEELKRSDQKVQMTLE---RERRLLLRQSQEQWQEKEQRKTLQS 324
K ++ ++ +Q K WE+ + +QK ++ +E+ + Q ++ W++++ K Q
Sbjct: 639 KMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQE 698
Query: 325 PEQRGLRRDSQRK--NVPPGESRWKEQPE---DQESPRQEKLEKARAQAEHRKQCQVRRL 379
E++ ++ R+ ++ E + +E+ E +QE QE+ EK + Q E + + +
Sbjct: 699 QEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMW 758
Query: 380 REQEKMLRNLR---------EQHSLQLQRRLVEACRKRH--LHAVEGQKKVQDTNLSSLI 428
++EKM R E +Q Q ++ E K + GQ++ +
Sbjct: 759 EQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMR 818
Query: 429 NYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLR--KERQRELREKAQKEEEQLQ 486
+ + + + +E E+ + + +++ + ++ +E+ RE EK + +EE+++
Sbjct: 819 GQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMR 878
Query: 487 QARWRAGESEEQ 498
+ + EE+
Sbjct: 879 EQEEKMRGQEEK 890
Score = 46.6 bits (109), Expect = 7e-05
Identities = 40/194 (20%), Positives = 90/194 (46%), Gaps = 18/194 (9%)
Query: 210 QKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKK 269
+K + Q + + D + + + MR K + EE ++ Q++++ K
Sbjct: 690 EKMEKKTQEQEKKTWDQEKMREEESMREREK---KMREEEEMMREQEEKMQE---QEEKM 743
Query: 270 AQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQ---WQEKEQRKTLQSPE 326
++ E+ +Q K WE+ ++ ++ ++ ++E+ + QEQ W+++E+ + Q +
Sbjct: 744 QEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRD-QEEK 802
Query: 327 QRGLR---RDSQRKNVPPGESRWKEQP-----EDQESPRQEKLEKARAQAEHRKQCQVRR 378
RG R + K E W ++ E++ ++EK+ + E + Q Q +
Sbjct: 803 MRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEK 862
Query: 379 LREQEKMLRNLREQ 392
+REQE+ +R E+
Sbjct: 863 MREQEEKMRGQEEK 876
Score = 42.4 bits (98), Expect = 0.001
Identities = 41/186 (22%), Positives = 82/186 (44%), Gaps = 14/186 (7%)
Query: 210 QKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKK 269
++R+ + E R+ + +E + + + EE + +++ L K+
Sbjct: 716 REREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKE 775
Query: 270 AQRIRELQQQAAKAWE-ELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQR 328
E Q+ K WE E K DQ+ +M + E+ +R +E+ + +E++ Q +
Sbjct: 776 KLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEK---MRGQEEKMRGQEEKMWGQEEKMW 832
Query: 329 GLRRD--SQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEKML 386
G Q + + E + +E+ + QE +E+ EK R Q E ++REQE+ +
Sbjct: 833 GQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEE--------KMREQEEKM 884
Query: 387 RNLREQ 392
R E+
Sbjct: 885 RGQEEK 890
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 74.3 bits (181), Expect = 3e-13
Identities = 88/379 (23%), Positives = 172/379 (45%), Gaps = 47/379 (12%)
Query: 245 SKLEEVVVSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRS------DQKVQMTL 298
++LE+ + +++D ++ V + K Q R+LQ + +A EE +R D +V+
Sbjct: 1574 TELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRD-EAGEERRRQLAKQLRDAEVERDE 1632
Query: 299 ERERRLLLRQSQEQWQ-EKEQRKTLQSPEQRGLRRDSQ--RKNVPPGESRWKEQPEDQES 355
ER++R L ++++ + E E+ K + +G + RK + W+E E + S
Sbjct: 1633 ERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTS 1692
Query: 356 PRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQR----------RLVEAC 405
R+E + R + K + LR QE++ + R + Q R L +A
Sbjct: 1693 -REEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAA 1751
Query: 406 ---RKRHLHAVEGQKKVQ---DTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRS 459
KR L GQ + + + + S L+N + RK+L+ + E L +LS E+SF
Sbjct: 1752 ILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLL----QVESLTTELSAERSFSAK 1807
Query: 460 QEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARS 519
E + Q+ E Q+Q+ R R GE + + R ++ + + K+ QA
Sbjct: 1808 AESGR--------------QQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEE 1853
Query: 520 HVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGK 579
+ + TR+++ +L EK + L+ E+E + + +++ ++K RV+ + +
Sbjct: 1854 QLEQETRERILS-GKLVRRAEKRLKEVVLQVEEERRV-ADQLRDQLEKGNLRVKQLKRQL 1911
Query: 580 DPNFQEFQKLPQASRREER 598
+ +E + RR +R
Sbjct: 1912 EEAEEEASRAQAGRRRLQR 1930
Score = 66.2 bits (160), Expect = 8e-11
Identities = 97/394 (24%), Positives = 182/394 (46%), Gaps = 43/394 (10%)
Query: 252 VSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLL---LRQ 308
V+ QD+ + A R ++ Q+++ELQQQ+A+ EL Q LE ER L LR
Sbjct: 872 VTRQDEVLQA----RAQELQKVQELQQQSAREVGEL----QGRVAQLEEERARLAEQLRA 923
Query: 309 SQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPG-ESRWKEQPEDQESPRQEKLEKARAQ 367
E E E+ + + ++ L G E Q + ++ Q+ +++ A
Sbjct: 924 EAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAH 983
Query: 368 AE----HRKQCQVRRLREQEKM------LRNLREQHS-LQLQRRLVE-ACRKRHLHAVEG 415
E R++ Q+ ++ + KM L L +Q+S L +R+L+E + A E
Sbjct: 984 LEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEE 1043
Query: 416 QKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQR----SQEIHQGLRKERQ 471
++KV+ N L Y+A M+ + + EE RQ LE+ +R S E+ + + +++Q
Sbjct: 1044 EEKVKSLNKLRL-KYEATIADMEDRLRKEEKGRQ-ELEKLKRRLDGESSELQEQMVEQQQ 1101
Query: 472 R--ELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKV 529
R ELR + ++EE+LQ A RA E++ R ++L L + + A + ++V
Sbjct: 1102 RAEELRAQLGRKEEELQAALARA---EDEGGARAQLLKSLREAQAALAEAQ-EDLESERV 1157
Query: 530 QHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIK-KKEQRVQHISQGKDPNFQEFQK 588
+ R+ + L+ E E+ ++ ++ K+EQ V + + +E +
Sbjct: 1158 ARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKK----TLEEETR 1213
Query: 589 LPQASRREERAPPNSSLDQMVLEAQLRACQQNRG 622
+ +A+ +E R +L + L QL ++ +G
Sbjct: 1214 IHEAAVQELRQRHGQALGE--LAEQLEQARRGKG 1245
Score = 49.3 bits (116), Expect = 1e-05
Identities = 80/371 (21%), Positives = 160/371 (43%), Gaps = 27/371 (7%)
Query: 240 TQVLKSKLEEVVVSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLE 299
T+ K EE ++ +DQ L R R+ E QAA+ E++K ++ + L+
Sbjct: 1001 TEAKMKKFEEDLLLLEDQNS-KLSKERKLLEDRLAEFSSQAAEEEEKVKSLNK---LRLK 1056
Query: 300 RERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQE 359
E + + + + +EK R+ L+ ++R S+ + + + E+ Q ++E
Sbjct: 1057 YEATIADMEDRLRKEEKG-RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEE 1115
Query: 360 KLEKARAQAEHRKQCQ---VRRLREQEKMLRNLREQ-HSLQLQRRLVEACRK---RHLHA 412
+L+ A A+AE + ++ LRE + L +E S ++ R E R+ L A
Sbjct: 1116 ELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEA 1175
Query: 413 VEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQR 472
+ G+ ++DT S+ + R +K E+ + +L +++ + IH+ +E ++
Sbjct: 1176 LRGE--LEDTLDSTNAQQELR-------SKREQEVTEL--KKTLEEETRIHEAAVQELRQ 1224
Query: 473 ELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADE--KIRQARSHVHKTTRDKVQ 530
+ + EQL+QAR G E+ R + + EL E ++ AR + R
Sbjct: 1225 RHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLEL 1284
Query: 531 HLRELNHLREKNHHILKLKAEKEEK--CHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQK 588
L+E+ AEK ++ +E + A+ + E + +S+ +
Sbjct: 1285 QLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHD 1344
Query: 589 LPQASRREERA 599
+ + E RA
Sbjct: 1345 AQELLQEETRA 1355
Score = 49.3 bits (116), Expect = 1e-05
Identities = 88/420 (20%), Positives = 171/420 (40%), Gaps = 53/420 (12%)
Query: 230 ASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKR 289
A+++E Q +++L E Q+++ AL + + RE + + E+ +
Sbjct: 1381 AAARERAGRELQTAQAQLSEWR-RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTET 1439
Query: 290 SDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQ 349
D+ LER RR L ++ + + EQ++ L S ++ R+ Q
Sbjct: 1440 VDR-----LERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQL------------L 1482
Query: 350 PEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACRKRH 409
E++ + + E+ RA+AE R++ + R L + + L+ Q R + A +
Sbjct: 1483 AEEKAAVLRAVEERERAEAEGRER-EARALSLTRALEEEQEAREELERQNRALRAELEAL 1541
Query: 410 LHAVEG-QKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIH-QGLR 467
L + + K V + + + QA D +A+ EL +L+ + + E+ Q L+
Sbjct: 1542 LSSKDDVGKSVHELERACRVAEQAAN---DLRAQVTELEDELTAAEDAKLRLEVTVQALK 1598
Query: 468 KERQRELREKAQKEEE-------QLQQARWRAGESEEQRKM----RKRILVELADEKIRQ 516
+ +R+L+ + + EE QL+ A E +QR + RK++ EL + K +
Sbjct: 1599 TQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQM 1658
Query: 517 ARS---------HVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEK-----CHIEGIK 562
A + + K + RE+ R I E E++ + ++
Sbjct: 1659 ASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQ 1718
Query: 563 EAIKKKEQRVQHISQGKDPNFQEFQ--KLPQASRREERAPPNSSLDQMVLEAQLRACQQN 620
E + ++ + Q +D E L +A+ EE+ L Q LE +L Q N
Sbjct: 1719 EELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQ--LEEELEEEQSN 1776
Score = 38.9 bits (89), Expect = 0.014
Identities = 60/305 (19%), Positives = 122/305 (40%), Gaps = 25/305 (8%)
Query: 198 QKFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLE-EVVVSSQD 256
++ K A K ++ Q+ + ++ + +E R+ ++ E E + +
Sbjct: 1652 EELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLE 1711
Query: 257 QQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEK 316
+++ L + R+ QQ + +E+ + LE +R+L R Q + + +
Sbjct: 1712 AEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELE 1771
Query: 317 EQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQV 376
E++ + L D RK + ES E ++ K E R Q E + Q
Sbjct: 1772 EEQSNSE------LLNDRYRKLLLQVESLTTELSAERSF--SAKAESGRQQLERQIQELR 1823
Query: 377 RRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVL 436
RL E++ R + L+ +L +A + +++ ++ LS + +A K L
Sbjct: 1824 GRLGEEDAGARARHKMTIAALESKLAQAEEQL-------EQETRERILSGKLVRRAEKRL 1876
Query: 437 MDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESE 496
+ + EE R + ++ L K R + K Q EE + + +R +AG
Sbjct: 1877 KEVVLQVEEERRV---------ADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRR 1927
Query: 497 EQRKM 501
QR++
Sbjct: 1928 LQREL 1932
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 74.3 bits (181), Expect = 3e-13
Identities = 88/379 (23%), Positives = 172/379 (45%), Gaps = 47/379 (12%)
Query: 245 SKLEEVVVSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRS------DQKVQMTL 298
++LE+ + +++D ++ V + K Q R+LQ + +A EE +R D +V+
Sbjct: 1566 TELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRD-EAGEERRRQLAKQLRDAEVERDE 1624
Query: 299 ERERRLLLRQSQEQWQ-EKEQRKTLQSPEQRGLRRDSQ--RKNVPPGESRWKEQPEDQES 355
ER++R L ++++ + E E+ K + +G + RK + W+E E + S
Sbjct: 1625 ERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTS 1684
Query: 356 PRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQR----------RLVEAC 405
R+E + R + K + LR QE++ + R + Q R L +A
Sbjct: 1685 -REEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAA 1743
Query: 406 ---RKRHLHAVEGQKKVQ---DTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRS 459
KR L GQ + + + + S L+N + RK+L+ + E L +LS E+SF
Sbjct: 1744 ILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLL----QVESLTTELSAERSFSAK 1799
Query: 460 QEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARS 519
E + Q+ E Q+Q+ R R GE + + R ++ + + K+ QA
Sbjct: 1800 AESGR--------------QQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEE 1845
Query: 520 HVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGK 579
+ + TR+++ +L EK + L+ E+E + + +++ ++K RV+ + +
Sbjct: 1846 QLEQETRERILS-GKLVRRAEKRLKEVVLQVEEERRV-ADQLRDQLEKGNLRVKQLKRQL 1903
Query: 580 DPNFQEFQKLPQASRREER 598
+ +E + RR +R
Sbjct: 1904 EEAEEEASRAQAGRRRLQR 1922
Score = 66.2 bits (160), Expect = 8e-11
Identities = 97/394 (24%), Positives = 182/394 (46%), Gaps = 43/394 (10%)
Query: 252 VSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLL---LRQ 308
V+ QD+ + A R ++ Q+++ELQQQ+A+ EL Q LE ER L LR
Sbjct: 864 VTRQDEVLQA----RAQELQKVQELQQQSAREVGEL----QGRVAQLEEERARLAEQLRA 915
Query: 309 SQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPG-ESRWKEQPEDQESPRQEKLEKARAQ 367
E E E+ + + ++ L G E Q + ++ Q+ +++ A
Sbjct: 916 EAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAH 975
Query: 368 AE----HRKQCQVRRLREQEKM------LRNLREQHS-LQLQRRLVE-ACRKRHLHAVEG 415
E R++ Q+ ++ + KM L L +Q+S L +R+L+E + A E
Sbjct: 976 LEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEE 1035
Query: 416 QKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQR----SQEIHQGLRKERQ 471
++KV+ N L Y+A M+ + + EE RQ LE+ +R S E+ + + +++Q
Sbjct: 1036 EEKVKSLNKLRL-KYEATIADMEDRLRKEEKGRQ-ELEKLKRRLDGESSELQEQMVEQQQ 1093
Query: 472 R--ELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKV 529
R ELR + ++EE+LQ A RA E++ R ++L L + + A + ++V
Sbjct: 1094 RAEELRAQLGRKEEELQAALARA---EDEGGARAQLLKSLREAQAALAEAQ-EDLESERV 1149
Query: 530 QHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIK-KKEQRVQHISQGKDPNFQEFQK 588
+ R+ + L+ E E+ ++ ++ K+EQ V + + +E +
Sbjct: 1150 ARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKK----TLEEETR 1205
Query: 589 LPQASRREERAPPNSSLDQMVLEAQLRACQQNRG 622
+ +A+ +E R +L + L QL ++ +G
Sbjct: 1206 IHEAAVQELRQRHGQALGE--LAEQLEQARRGKG 1237
Score = 49.3 bits (116), Expect = 1e-05
Identities = 80/371 (21%), Positives = 160/371 (43%), Gaps = 27/371 (7%)
Query: 240 TQVLKSKLEEVVVSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLE 299
T+ K EE ++ +DQ L R R+ E QAA+ E++K ++ + L+
Sbjct: 993 TEAKMKKFEEDLLLLEDQNS-KLSKERKLLEDRLAEFSSQAAEEEEKVKSLNK---LRLK 1048
Query: 300 RERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQE 359
E + + + + +EK R+ L+ ++R S+ + + + E+ Q ++E
Sbjct: 1049 YEATIADMEDRLRKEEKG-RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEE 1107
Query: 360 KLEKARAQAEHRKQCQ---VRRLREQEKMLRNLREQ-HSLQLQRRLVEACRK---RHLHA 412
+L+ A A+AE + ++ LRE + L +E S ++ R E R+ L A
Sbjct: 1108 ELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEA 1167
Query: 413 VEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQR 472
+ G+ ++DT S+ + R +K E+ + +L +++ + IH+ +E ++
Sbjct: 1168 LRGE--LEDTLDSTNAQQELR-------SKREQEVTEL--KKTLEEETRIHEAAVQELRQ 1216
Query: 473 ELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADE--KIRQARSHVHKTTRDKVQ 530
+ + EQL+QAR G E+ R + + EL E ++ AR + R
Sbjct: 1217 RHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLEL 1276
Query: 531 HLRELNHLREKNHHILKLKAEKEEK--CHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQK 588
L+E+ AEK ++ +E + A+ + E + +S+ +
Sbjct: 1277 QLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHD 1336
Query: 589 LPQASRREERA 599
+ + E RA
Sbjct: 1337 AQELLQEETRA 1347
Score = 49.3 bits (116), Expect = 1e-05
Identities = 88/420 (20%), Positives = 171/420 (40%), Gaps = 53/420 (12%)
Query: 230 ASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKR 289
A+++E Q +++L E Q+++ AL + + RE + + E+ +
Sbjct: 1373 AAARERAGRELQTAQAQLSEWR-RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTET 1431
Query: 290 SDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQ 349
D+ LER RR L ++ + + EQ++ L S ++ R+ Q
Sbjct: 1432 VDR-----LERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQL------------L 1474
Query: 350 PEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACRKRH 409
E++ + + E+ RA+AE R++ + R L + + L+ Q R + A +
Sbjct: 1475 AEEKAAVLRAVEERERAEAEGRER-EARALSLTRALEEEQEAREELERQNRALRAELEAL 1533
Query: 410 LHAVEG-QKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIH-QGLR 467
L + + K V + + + QA D +A+ EL +L+ + + E+ Q L+
Sbjct: 1534 LSSKDDVGKSVHELERACRVAEQAAN---DLRAQVTELEDELTAAEDAKLRLEVTVQALK 1590
Query: 468 KERQRELREKAQKEEE-------QLQQARWRAGESEEQRKM----RKRILVELADEKIRQ 516
+ +R+L+ + + EE QL+ A E +QR + RK++ EL + K +
Sbjct: 1591 TQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQM 1650
Query: 517 ARS---------HVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEK-----CHIEGIK 562
A + + K + RE+ R I E E++ + ++
Sbjct: 1651 ASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQ 1710
Query: 563 EAIKKKEQRVQHISQGKDPNFQEFQ--KLPQASRREERAPPNSSLDQMVLEAQLRACQQN 620
E + ++ + Q +D E L +A+ EE+ L Q LE +L Q N
Sbjct: 1711 EELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQ--LEEELEEEQSN 1768
Score = 38.9 bits (89), Expect = 0.014
Identities = 60/305 (19%), Positives = 122/305 (40%), Gaps = 25/305 (8%)
Query: 198 QKFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLE-EVVVSSQD 256
++ K A K ++ Q+ + ++ + +E R+ ++ E E + +
Sbjct: 1644 EELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLE 1703
Query: 257 QQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEK 316
+++ L + R+ QQ + +E+ + LE +R+L R Q + + +
Sbjct: 1704 AEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELE 1763
Query: 317 EQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQV 376
E++ + L D RK + ES E ++ K E R Q E + Q
Sbjct: 1764 EEQSNSE------LLNDRYRKLLLQVESLTTELSAERSF--SAKAESGRQQLERQIQELR 1815
Query: 377 RRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVL 436
RL E++ R + L+ +L +A + +++ ++ LS + +A K L
Sbjct: 1816 GRLGEEDAGARARHKMTIAALESKLAQAEEQL-------EQETRERILSGKLVRRAEKRL 1868
Query: 437 MDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESE 496
+ + EE R + ++ L K R + K Q EE + + +R +AG
Sbjct: 1869 KEVVLQVEEERRV---------ADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRR 1919
Query: 497 EQRKM 501
QR++
Sbjct: 1920 LQREL 1924
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 74.3 bits (181), Expect = 3e-13
Identities = 88/379 (23%), Positives = 172/379 (45%), Gaps = 47/379 (12%)
Query: 245 SKLEEVVVSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRS------DQKVQMTL 298
++LE+ + +++D ++ V + K Q R+LQ + +A EE +R D +V+
Sbjct: 1607 TELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRD-EAGEERRRQLAKQLRDAEVERDE 1665
Query: 299 ERERRLLLRQSQEQWQ-EKEQRKTLQSPEQRGLRRDSQ--RKNVPPGESRWKEQPEDQES 355
ER++R L ++++ + E E+ K + +G + RK + W+E E + S
Sbjct: 1666 ERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTS 1725
Query: 356 PRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQR----------RLVEAC 405
R+E + R + K + LR QE++ + R + Q R L +A
Sbjct: 1726 -REEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAA 1784
Query: 406 ---RKRHLHAVEGQKKVQ---DTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRS 459
KR L GQ + + + + S L+N + RK+L+ + E L +LS E+SF
Sbjct: 1785 ILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLL----QVESLTTELSAERSFSAK 1840
Query: 460 QEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARS 519
E + Q+ E Q+Q+ R R GE + + R ++ + + K+ QA
Sbjct: 1841 AESGR--------------QQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEE 1886
Query: 520 HVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGK 579
+ + TR+++ +L EK + L+ E+E + + +++ ++K RV+ + +
Sbjct: 1887 QLEQETRERILS-GKLVRRAEKRLKEVVLQVEEERRV-ADQLRDQLEKGNLRVKQLKRQL 1944
Query: 580 DPNFQEFQKLPQASRREER 598
+ +E + RR +R
Sbjct: 1945 EEAEEEASRAQAGRRRLQR 1963
Score = 66.2 bits (160), Expect = 8e-11
Identities = 97/394 (24%), Positives = 182/394 (46%), Gaps = 43/394 (10%)
Query: 252 VSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLL---LRQ 308
V+ QD+ + A R ++ Q+++ELQQQ+A+ EL Q LE ER L LR
Sbjct: 905 VTRQDEVLQA----RAQELQKVQELQQQSAREVGEL----QGRVAQLEEERARLAEQLRA 956
Query: 309 SQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPG-ESRWKEQPEDQESPRQEKLEKARAQ 367
E E E+ + + ++ L G E Q + ++ Q+ +++ A
Sbjct: 957 EAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAH 1016
Query: 368 AE----HRKQCQVRRLREQEKM------LRNLREQHS-LQLQRRLVE-ACRKRHLHAVEG 415
E R++ Q+ ++ + KM L L +Q+S L +R+L+E + A E
Sbjct: 1017 LEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEE 1076
Query: 416 QKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQR----SQEIHQGLRKERQ 471
++KV+ N L Y+A M+ + + EE RQ LE+ +R S E+ + + +++Q
Sbjct: 1077 EEKVKSLNKLRL-KYEATIADMEDRLRKEEKGRQ-ELEKLKRRLDGESSELQEQMVEQQQ 1134
Query: 472 R--ELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKV 529
R ELR + ++EE+LQ A RA E++ R ++L L + + A + ++V
Sbjct: 1135 RAEELRAQLGRKEEELQAALARA---EDEGGARAQLLKSLREAQAALAEAQ-EDLESERV 1190
Query: 530 QHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIK-KKEQRVQHISQGKDPNFQEFQK 588
+ R+ + L+ E E+ ++ ++ K+EQ V + + +E +
Sbjct: 1191 ARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKK----TLEEETR 1246
Query: 589 LPQASRREERAPPNSSLDQMVLEAQLRACQQNRG 622
+ +A+ +E R +L + L QL ++ +G
Sbjct: 1247 IHEAAVQELRQRHGQALGE--LAEQLEQARRGKG 1278
Score = 49.3 bits (116), Expect = 1e-05
Identities = 80/371 (21%), Positives = 160/371 (43%), Gaps = 27/371 (7%)
Query: 240 TQVLKSKLEEVVVSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLE 299
T+ K EE ++ +DQ L R R+ E QAA+ E++K ++ + L+
Sbjct: 1034 TEAKMKKFEEDLLLLEDQNS-KLSKERKLLEDRLAEFSSQAAEEEEKVKSLNK---LRLK 1089
Query: 300 RERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQE 359
E + + + + +EK R+ L+ ++R S+ + + + E+ Q ++E
Sbjct: 1090 YEATIADMEDRLRKEEKG-RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEE 1148
Query: 360 KLEKARAQAEHRKQCQ---VRRLREQEKMLRNLREQ-HSLQLQRRLVEACRK---RHLHA 412
+L+ A A+AE + ++ LRE + L +E S ++ R E R+ L A
Sbjct: 1149 ELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEA 1208
Query: 413 VEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQR 472
+ G+ ++DT S+ + R +K E+ + +L +++ + IH+ +E ++
Sbjct: 1209 LRGE--LEDTLDSTNAQQELR-------SKREQEVTEL--KKTLEEETRIHEAAVQELRQ 1257
Query: 473 ELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADE--KIRQARSHVHKTTRDKVQ 530
+ + EQL+QAR G E+ R + + EL E ++ AR + R
Sbjct: 1258 RHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLEL 1317
Query: 531 HLRELNHLREKNHHILKLKAEKEEK--CHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQK 588
L+E+ AEK ++ +E + A+ + E + +S+ +
Sbjct: 1318 QLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHD 1377
Query: 589 LPQASRREERA 599
+ + E RA
Sbjct: 1378 AQELLQEETRA 1388
Score = 49.3 bits (116), Expect = 1e-05
Identities = 88/420 (20%), Positives = 171/420 (40%), Gaps = 53/420 (12%)
Query: 230 ASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKR 289
A+++E Q +++L E Q+++ AL + + RE + + E+ +
Sbjct: 1414 AAARERAGRELQTAQAQLSEWR-RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTET 1472
Query: 290 SDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQ 349
D+ LER RR L ++ + + EQ++ L S ++ R+ Q
Sbjct: 1473 VDR-----LERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQL------------L 1515
Query: 350 PEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACRKRH 409
E++ + + E+ RA+AE R++ + R L + + L+ Q R + A +
Sbjct: 1516 AEEKAAVLRAVEERERAEAEGRER-EARALSLTRALEEEQEAREELERQNRALRAELEAL 1574
Query: 410 LHAVEG-QKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIH-QGLR 467
L + + K V + + + QA D +A+ EL +L+ + + E+ Q L+
Sbjct: 1575 LSSKDDVGKSVHELERACRVAEQAAN---DLRAQVTELEDELTAAEDAKLRLEVTVQALK 1631
Query: 468 KERQRELREKAQKEEE-------QLQQARWRAGESEEQRKM----RKRILVELADEKIRQ 516
+ +R+L+ + + EE QL+ A E +QR + RK++ EL + K +
Sbjct: 1632 TQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQM 1691
Query: 517 ARS---------HVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEK-----CHIEGIK 562
A + + K + RE+ R I E E++ + ++
Sbjct: 1692 ASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQ 1751
Query: 563 EAIKKKEQRVQHISQGKDPNFQEFQ--KLPQASRREERAPPNSSLDQMVLEAQLRACQQN 620
E + ++ + Q +D E L +A+ EE+ L Q LE +L Q N
Sbjct: 1752 EELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQ--LEEELEEEQSN 1809
Score = 38.9 bits (89), Expect = 0.014
Identities = 60/305 (19%), Positives = 122/305 (40%), Gaps = 25/305 (8%)
Query: 198 QKFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLE-EVVVSSQD 256
++ K A K ++ Q+ + ++ + +E R+ ++ E E + +
Sbjct: 1685 EELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLE 1744
Query: 257 QQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEK 316
+++ L + R+ QQ + +E+ + LE +R+L R Q + + +
Sbjct: 1745 AEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELE 1804
Query: 317 EQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQV 376
E++ + L D RK + ES E ++ K E R Q E + Q
Sbjct: 1805 EEQSNSE------LLNDRYRKLLLQVESLTTELSAERSF--SAKAESGRQQLERQIQELR 1856
Query: 377 RRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVL 436
RL E++ R + L+ +L +A + +++ ++ LS + +A K L
Sbjct: 1857 GRLGEEDAGARARHKMTIAALESKLAQAEEQL-------EQETRERILSGKLVRRAEKRL 1909
Query: 437 MDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESE 496
+ + EE R + ++ L K R + K Q EE + + +R +AG
Sbjct: 1910 KEVVLQVEEERRV---------ADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRR 1960
Query: 497 EQRKM 501
QR++
Sbjct: 1961 LQREL 1965
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 73.9 bits (180), Expect = 4e-13
Identities = 98/446 (21%), Positives = 208/446 (46%), Gaps = 62/446 (13%)
Query: 205 ACVCAQKRDSSDQVESLAS-RDSQPLA------SSKEMRSPHTQVLKSKLEEVVVSSQDQ 257
+ V QK+ + +E L RD+ L + +E++ + + L+ KL+ V +
Sbjct: 182 SAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAK-LQEKLQLVESEKSEI 240
Query: 258 QIVALVLTR-LKKAQRI---RELQQQAAKAWEELKRSDQKVQMTLERER---RLLLRQSQ 310
Q+ L R L++A+ + ++LQ +A +EL+ K+Q +E RL +Q +
Sbjct: 241 QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEE 300
Query: 311 EQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPED---QESPRQEKLEKARAQ 367
+ W+++E+ + + Q Q + + E + +EQ E QE EK EK R Q
Sbjct: 301 KMWRQEEKIQEWEEKIQE------QEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQ 354
Query: 368 AEHRKQCQVRRLREQEKML----RNLREQHSLQLQ-----RRLVEACRKRHLHAVEGQKK 418
E + + ++R QE+M+ +R Q + + R L E ++ + +K+
Sbjct: 355 EEMMWE-KEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKR 413
Query: 419 VQDTNLSSLINYQARKVLMDCQ----AKAEELLRQLSLEQSFQRSQEIH--QGLRKERQR 472
++ + Q ++ M Q + EE +R+ ++ +++ ++IH + +R+E +R
Sbjct: 414 QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE-KKMWRQEEKIHEQEKIREEEKR 472
Query: 473 ELREKAQKEEEQL--QQARWRAGES--EEQRKMRKR-ILVELADEKIRQARSHVHK---- 523
+ +E+ ++EE++ Q+ WR E E++ K+RK+ V +EKIR+ + +
Sbjct: 473 QEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEK 532
Query: 524 --TTRDKVQHLRELNHLREKNHHILKL-----KAEKEEKC-----HIEGIKEAIKKKEQR 571
+K++ E+ EK H K+ + E+E+K I +E + ++E++
Sbjct: 533 MWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEK 592
Query: 572 VQHISQGKDPNFQEFQKLPQASRREE 597
++ + + ++ K + R +E
Sbjct: 593 IREQEEKRQEQEEKMWKQEEKIREQE 618
Score = 73.2 bits (178), Expect = 7e-13
Identities = 76/361 (21%), Positives = 174/361 (48%), Gaps = 31/361 (8%)
Query: 271 QRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSP--EQR 328
++ ++++Q WE+ ++ ++ +M E+E + + RQ + W+++E+ + L+ EQ
Sbjct: 346 EKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK-MRRQEEMMWEKEEKIRELEEKMHEQE 404
Query: 329 GLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEKM--L 386
+ R+ + K + R +E+ ++QE+ + EK R Q E ++ + + R++EK+
Sbjct: 405 KI-REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQ 463
Query: 387 RNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEEL 446
+RE+ Q Q + K H ++K + I Q KV + EE
Sbjct: 464 EKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVW-----RQEEK 518
Query: 447 LRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQAR-WRAGESEEQRKMRKRI 505
+R+ ++ R QE ++E+ RE E ++EE+ +Q + W EE+++ +
Sbjct: 519 IRE---QEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIW-----EEEKRQEQED 570
Query: 506 LVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEK--EEKCHIEGIKE 563
+ +EKIR+ V + + + +RE R++ + + EK E++ I+ +E
Sbjct: 571 KMWRQEEKIREQEEKVWR----QEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEE 626
Query: 564 AIKKKEQRV---QHISQGKDPNF--QEFQKLPQASRREERAPPNSSLDQMVLEAQLRACQ 618
I+++E+++ + ++Q ++ QE + Q + +E+ ++ + E + + +
Sbjct: 627 KIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIRE 686
Query: 619 Q 619
Q
Sbjct: 687 Q 687
Score = 69.7 bits (169), Expect = 8e-12
Identities = 69/344 (20%), Positives = 165/344 (47%), Gaps = 20/344 (5%)
Query: 244 KSKLEEVVVSSQDQQIVALVLTRLKKAQRIREL---QQQAAKAWEELKRSDQKVQMTLER 300
+ K+ E+ +Q+ + + ++ ++IRE Q+Q AK W + ++ ++ + E+
Sbjct: 390 EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 449
Query: 301 ERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEK 360
E+++ RQ ++ ++++ R+ + EQ + R ++ + R KE+ +QE +++
Sbjct: 450 EKKMW-RQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQ 508
Query: 361 LEKARAQAEHRKQCQVRRLREQEKMLRN---LREQHSLQLQRRLVEACRKRHLHAVEGQK 417
EK Q E ++ + + ++EKM R +REQ + + + K ++
Sbjct: 509 EEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQ 568
Query: 418 KVQDTNLSSLINYQARKVL-MDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELRE 476
+ + I Q KV + + + +E RQ E+ +++ ++I + K +++E +
Sbjct: 569 EDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKI 628
Query: 477 KAQKE-----EEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARS--HVHKTTRDKV 529
+ Q+E EE Q+ + GE EE+ ++ + E + RQ K R++
Sbjct: 629 REQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQE 688
Query: 530 QHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQ 573
+ +RE + ++ K+ ++E+ C E E ++++E++++
Sbjct: 689 EKIREQEEMMQEQEE--KMWEQEEKMCEQE---EKMQEQEEKMR 727
Score = 60.1 bits (144), Expect = 6e-09
Identities = 63/310 (20%), Positives = 144/310 (46%), Gaps = 65/310 (20%)
Query: 268 KKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRL--LLRQSQEQWQEKEQRKTLQSP 325
++ ++IR+ +++ + E+++ ++K++ E+ R +R+ +E W+E+E+
Sbjct: 500 EQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMH----- 554
Query: 326 EQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEKM 385
EQ + + +R+ R +E+ +QE + EK R Q E R++ + + +++EK
Sbjct: 555 EQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEK- 613
Query: 386 LRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEE 445
+REQ ++K+Q+ Q K+ + EE
Sbjct: 614 ---IREQ-----------------------EEKIQE---------QEEKI-----REQEE 633
Query: 446 LLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGES--EEQRKMRK 503
+R+ ++ + QE G ++E+ E EK Q++EE + WR E E+++K+R+
Sbjct: 634 KIRE---QEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETM----WRQEEKIREQEKKIRE 686
Query: 504 RILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKE 563
+ +EKIR+ + + + ++ EK + +EEK + ++
Sbjct: 687 Q------EEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVR- 739
Query: 564 AIKKKEQRVQ 573
++++E+++Q
Sbjct: 740 -LRQQEEKMQ 748
Score = 50.8 bits (120), Expect = 4e-06
Identities = 60/301 (19%), Positives = 136/301 (45%), Gaps = 60/301 (19%)
Query: 210 QKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKS-----KLEEVVVSSQDQQIVALVL 264
QK +Q E + ++ + +++R ++ + + EE + ++ +
Sbjct: 494 QKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKM 553
Query: 265 TRLKKAQRIRELQQQAAKAW---EELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKT 321
+K + Q+Q K W E+++ ++KV E+ +R+ +E+ QE+E++
Sbjct: 554 HEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEK-----IREQEEKRQEQEEKMW 608
Query: 322 LQSPEQRGLRRDSQRKNVPPGESRWKEQPE---DQESPRQEKLEKARAQAEHRKQC-QVR 377
Q + R Q + + E + +EQ E +QE QE+ EK Q E K C Q
Sbjct: 609 KQEEKIR-----EQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEE--KMCEQEE 661
Query: 378 RLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLM 437
+++EQE+ + R++ ++ E +KK+++ Q K+
Sbjct: 662 KMQEQEETM--WRQEEKIR-----------------EQEKKIRE---------QEEKI-- 691
Query: 438 DCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEE 497
+ +E + Q E+ +++ +++ + ++E+ +E EK +++EE++ + R + EE
Sbjct: 692 ----REQEEMMQEQEEKMWEQEEKMCE--QEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE 745
Query: 498 Q 498
+
Sbjct: 746 K 746
Score = 50.1 bits (118), Expect = 6e-06
Identities = 65/306 (21%), Positives = 128/306 (41%), Gaps = 51/306 (16%)
Query: 360 KLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLV--------EACRKRHLH 411
+LE+A + +K+ R + E K R+ SL+L R + A + L
Sbjct: 176 ELEQALSAVATQKKKADRYIEELTKE----RDALSLELYRNTITDEELKEKNAKLQEKLQ 231
Query: 412 AVEGQKKVQDTNLSSLINYQARKVLM----DCQAKAEELLRQLS--------------LE 453
VE +K N+ L R L+ QA+A+ L ++L L
Sbjct: 232 LVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELW 291
Query: 454 QSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEK 513
+ QE ++E+ +E EK Q++EE++++ + E EE+ + ++ ++ E ++
Sbjct: 292 NRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKM 351
Query: 514 IRQARSHVHKTTR---------DKVQHLR-----------ELNHLREKNHHILKLKAEKE 553
RQ K + +K + +R ++ L EK H K++ ++E
Sbjct: 352 RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE 411
Query: 554 EKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREERAPPNSSLDQMVLEAQ 613
++ E I+E K++EQ + Q + QE +K+ + ++ R + + E +
Sbjct: 412 KRQEEEKIREQEKRQEQEAKMWRQEEKIREQE-EKIREQEKKMWRQEEKIHEQEKIREEE 470
Query: 614 LRACQQ 619
R Q+
Sbjct: 471 KRQEQE 476
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 73.9 bits (180), Expect = 4e-13
Identities = 94/432 (21%), Positives = 193/432 (44%), Gaps = 65/432 (15%)
Query: 214 SSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLK----K 269
S +Q E A+R Q A + R + ++ L +++ ++ + RLK +
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2020
Query: 270 AQRIRE-LQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQR 328
A+R+RE +Q++A+ + + + QK E+ ++Q +++ Q+ Q++ + R
Sbjct: 2021 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080
Query: 329 GLRRDSQRKNVPPGESRWKEQPEDQESPRQ----EKLEK-ARAQAEHRKQCQ-----VRR 378
G ++R E+R + + E +S RQ E+L++ A QA+ R Q Q +R+
Sbjct: 2081 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2140
Query: 379 LREQEKMLRNLREQHSLQLQRRLVEACRKRH------------------------LHAVE 414
EQE R EQ +L+ Q++ +A ++H L +
Sbjct: 2141 EAEQEAARRAQAEQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199
Query: 415 GQKKVQDTNLSSLI---------NYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQG 465
QK + D L L Q + L + + EEL + + ++ R+ +
Sbjct: 2200 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD- 2258
Query: 466 LRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTT 525
+ QR L+E+A+K ++ ++A + ++E ++R +LA+E + Q R+ K
Sbjct: 2259 -KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR-----QLAEEDLAQQRALAEKML 2312
Query: 526 RDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQE 585
++K+Q ++E L+ + + + K +E+ + + KEQ Q +++ Q
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQA-----RRLQEDKEQMAQQLAE----ETQG 2363
Query: 586 FQKLPQASRREE 597
FQ+ +A R+ +
Sbjct: 2364 FQRTLEAERQRQ 2375
Score = 72.4 bits (176), Expect = 1e-12
Identities = 85/327 (25%), Positives = 148/327 (45%), Gaps = 40/327 (12%)
Query: 254 SQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQW 313
S ++ VA+ R ++A+R + Q +A +A EE +R ++ Q+ RL L Q++E
Sbjct: 1595 SLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL-QAEEVA 1652
Query: 314 QEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQ 373
Q+K + ++ R+++R+ ++ + + +QE +Q +L + AQ +
Sbjct: 1653 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1712
Query: 374 CQVRRLR---EQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINY 430
++ RLR EQ + R L E+ +LQR A +KR E K +
Sbjct: 1713 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE--------- 1763
Query: 431 QARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARW 490
+VL+ +A+AEE R S E+S QR + R REL E+A AR
Sbjct: 1764 --MEVLLASKARAEEESRSTS-EKSKQRLE-----AEAGRFRELAEEA---------ARL 1806
Query: 491 RAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKA 550
RA E +R+ +LA+E + R+ + +K+ + E L+ + LK K
Sbjct: 1807 RALAEEAKRQR------QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1860
Query: 551 EKEEKCHIEGIKEAIKKK---EQRVQH 574
+ E+ EA +++ EQ QH
Sbjct: 1861 AENERLRRLAEDEAFQRRRLEEQAAQH 1887
Score = 72.4 bits (176), Expect = 1e-12
Identities = 94/422 (22%), Positives = 181/422 (42%), Gaps = 36/422 (8%)
Query: 199 KFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQ- 257
+ K + +K ++++ LA ++ +E + H ++ +L ++ +S +
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1906
Query: 258 -QIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEK 316
+ LV L++ +++ E + A KA E K + K ++ LE R +R + E
Sbjct: 1907 ERQKGLVEDTLRQRRQVEE-EILALKASFE-KAAAGKAELELELGR---IRSNAEDTLRS 1961
Query: 317 EQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQV 376
+++ L++ QR L + +R+ E K ++E+ RQ K + K +
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021
Query: 377 RRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVL 436
RRLRE+ + + Q + + ++ ++A K H AV+ +++ L Q + VL
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ-----QEQSVL 2076
Query: 437 MDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESE 496
+ +A E R+ + E R Q + + RQ E E+ ++ E+ QAR +A +
Sbjct: 2077 DQLRGEA-EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2135
Query: 497 EQRKMRKRILVE----------------LADEKIRQARSHVHKTTRDKVQHLRELNHLR- 539
E K+RK E AD ++ + + +T R K Q +EL LR
Sbjct: 2136 E--KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2193
Query: 540 --EKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREE 597
E+ H L E+ ++ E EA +++ Q + + + +E KL E
Sbjct: 2194 QLEETDHQKNLLDEELQRLKAEA-TEAARQRSQVEEELFSVR-VQMEELSKLKARIEAEN 2251
Query: 598 RA 599
RA
Sbjct: 2252 RA 2253
Score = 70.5 bits (171), Expect = 4e-12
Identities = 106/495 (21%), Positives = 204/495 (41%), Gaps = 65/495 (13%)
Query: 178 RHLGRWSPSSVPSERSSVPSQKFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRS 237
R L RW + + R + +++ + + A+ ++ E A R + + R
Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1688
Query: 238 PHTQVLKSKLEEVVVSSQDQQIVALVLTRLKK------------AQRIRELQQQAAKAWE 285
Q L+ + + ++Q + L RL+ + + LQ++AA A +
Sbjct: 1689 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1748
Query: 286 ELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQ---------RGLRRDSQR 336
KR + + ++ R +L S+ + E+E R T + +Q R L ++ R
Sbjct: 1749 --KRQELEAELAKVRAEMEVLLASKAR-AEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1805
Query: 337 KNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQC-QVRRLREQEKMLRNLREQHSL 395
E++ + Q ++++ RQ + E R AE + RL+ + ++ +E +
Sbjct: 1806 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1864
Query: 396 QLQRRLV--EACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQ---- 449
+L RRL EA ++R L Q K + + + L + E+ LRQ
Sbjct: 1865 RL-RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1923
Query: 450 ----LSLEQSFQRSQ------EIHQG-LRKERQRELREKAQKEEEQLQQARWRAGESEEQ 498
L+L+ SF+++ E+ G +R + LR K Q E E +Q + A E +
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1983
Query: 499 RKMRKRILVELA--DEKIRQARSHVHKTTR--DKVQHLRELNHLREKN--------HHIL 546
R+ +R+ LA +E RQ ++ + + R KV+ R L E+
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043
Query: 547 KLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREERAPPNSSLD 606
+ + + EEK H A+++KEQ +Q Q + + + +A+RR +
Sbjct: 2044 QKRLQAEEKAH----AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA-----EEAE 2094
Query: 607 QMVLEAQLRACQQNR 621
+ ++A+ A Q R
Sbjct: 2095 EARVQAEREAAQSRR 2109
Score = 67.8 bits (164), Expect = 3e-11
Identities = 101/422 (23%), Positives = 181/422 (42%), Gaps = 63/422 (14%)
Query: 234 EMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKKAQ-RIRELQQQAAKAWEELKRSDQ 292
+ R+ ++LK K++ V +++ + L+ + + AQ + R LQ+ + ++L Q
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2362
Query: 293 KVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPED 352
Q TLE ER+ L S E + + R S Q D+QR E E+
Sbjct: 2363 GFQRTLEAERQRQLEMSAEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG--EKLHR 2419
Query: 353 QESPRQEK------LEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACR 406
E QEK LE R Q++H RLRE L RE+ LQ + +L++ +
Sbjct: 2420 TELATQEKVTLVQTLEIQRQQSDH----DAERLREAIAELE--REKEKLQQEAKLLQL-K 2472
Query: 407 KRHLHAVEGQKKVQDTNL---------SSLINYQARKVLMDCQAKAEELLR-------QL 450
+ V+ ++ +Q+T SL+ Q + + +AK E+L + QL
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLL--QRERFIEQEKAKLEQLFQDEVAKAQQL 2530
Query: 451 SLEQSFQRSQEIHQGLR--------KERQRELRE---KAQKEEEQLQQARWRAGESEEQR 499
EQ Q+ Q + R + RQ E E + Q+E +QL+Q R + E +
Sbjct: 2531 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE 2590
Query: 500 KMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIE 559
R R ++L +E+ R A +H + T +V + L + R+ + AE E + +
Sbjct: 2591 NQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA---LDGPAAEAEPEHSFD 2647
Query: 560 GIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREERAPPNSSLDQMVLEAQLRACQQ 619
G++ + Q + + + +E Q+L Q ++++D++ +R Q
Sbjct: 2648 GLRRKVS-----AQRLQEAGILSAEELQRLAQG---------HTTVDELARREDVRHYLQ 2693
Query: 620 NR 621
R
Sbjct: 2694 GR 2695
Score = 60.5 bits (145), Expect = 5e-09
Identities = 76/380 (20%), Positives = 174/380 (45%), Gaps = 57/380 (15%)
Query: 210 QKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKK 269
Q+ + ++++L +R + A ++ + ++ + +E S + +Q + +R+K
Sbjct: 1467 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE---SQRKRQAEVELASRVKA 1523
Query: 270 AQRIRELQQQAAKAWEELKRSDQKVQMTLE-------RERRLLLRQSQEQWQEKEQRKTL 322
+Q+A +A EEL+ ++ + L R+ ++ L +Q + + Q K
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1583
Query: 323 QSPEQRG-LRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLRE 381
E+ L R Q ++V + R + ++ + +Q + E+AR +AE RE
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLR---EEAERRAQQQAEAERAREEAE----------RE 1630
Query: 382 QEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQA 441
E+ L+ +L+L+ + E +++ L E +K+ ++ +AR+ +
Sbjct: 1631 LERW--QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA------EREARR-----RG 1677
Query: 442 KAEE-LLRQLSL-EQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQR 499
KAEE +RQ L EQ ++ +++ +G ++R E++L + R + E+QR
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQR--------LAAEQELIRLRAETEQGEQQR 1729
Query: 500 KMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHIL--KLKAEKEEKCH 557
+L +E++ + + T+ + + EL +R + +L K +AE+E +
Sbjct: 1730 --------QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1781
Query: 558 IEGIKEAIKKKEQRVQHISQ 577
E K+ ++ + R + +++
Sbjct: 1782 SEKSKQRLEAEAGRFRELAE 1801
Score = 52.0 bits (123), Expect = 2e-06
Identities = 60/286 (20%), Positives = 128/286 (44%), Gaps = 12/286 (4%)
Query: 298 LERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPR 357
+E E RL +Q E+ + + + +++ +Q K E++ +Q +E R
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 358 QEKLEKARAQAEHRKQCQVRRLRE--QEKMLRNLREQHSLQLQR-RLVEACR--KRHLHA 412
+E+ Q + Q ++++LR+ + ++ R+ + + R R+ E R + L A
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1463
Query: 413 VEGQKKVQDTNLSSL--INYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKER 470
E Q+ + L +L +A Q +AE L RQ+ E +R E+ R +
Sbjct: 1464 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1523
Query: 471 QRELREKAQKEEEQLQQARWRAGESE---EQRKMRKRILVELADEKI-RQARSHVHKTTR 526
+ E + Q+ + L++ R +A E+E Q ++ + V++A E R A + +
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1583
Query: 527 DKVQHLRELNH-LREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQR 571
+ +L L+E++ + +L+ E E + + E +++ +R
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629
Score = 49.3 bits (116), Expect = 1e-05
Identities = 96/469 (20%), Positives = 186/469 (39%), Gaps = 64/469 (13%)
Query: 202 RHSACVCAQKRDSSDQVESLASRDSQPLASSKEMR-----SPHTQVLKSKLEEVVVS-SQ 255
R A A+++ + +VE L ++ A ++++ SP L+S+LE + Q
Sbjct: 1017 RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ 1076
Query: 256 DQQIVALVLTRLKKAQR-IRELQ--QQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQ 312
+ + A+ L +LK IR Q ++ +A EE + Q V TL + +
Sbjct: 1077 VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1136
Query: 313 WQEKEQRKTLQS--PEQRGLRRDSQRKNVPPGE-----SRWKEQPED----------QES 355
Q + Q+ T + E RG + +R GE RW+E+ Q
Sbjct: 1137 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1196
Query: 356 PRQEKLEKARAQAEHRKQC--------QVRRLREQEKMLRNLREQHSLQLQRRLVEACRK 407
RQ +LE+ Q + ++ Q R R+++ L + +++ Q R +A +
Sbjct: 1197 VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE 1256
Query: 408 ---RHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQ 464
RH VE ++ ++++ +Y+ + V Q L S + ++
Sbjct: 1257 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ---------LEPVASPAKKPKVQS 1307
Query: 465 GLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKT 524
G Q + + E +++ SE R+M + +E++ + + +
Sbjct: 1308 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE-------EERLAEQQRAEERE 1360
Query: 525 TRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQ 584
+V+ E + H K +AE+E K + ++E + ++E+ Q K +
Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1420
Query: 585 EFQKLPQASRRE-----------ERAPPNSSLDQMVLEAQLRACQQNRG 622
E Q+L Q+S E ER+ + V+ QL A ++ RG
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1469
Score = 48.5 bits (114), Expect = 2e-05
Identities = 96/440 (21%), Positives = 183/440 (41%), Gaps = 80/440 (18%)
Query: 238 PHTQVLKSKLEEVVVSSQDQQIVALVLT-RLKKAQRIRE-LQQQAAKAWEELKRSDQKVQ 295
P + K+ L+++ ++ QQ L L+ AQ + E LQQ+ + E++R ++V
Sbjct: 1123 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1182
Query: 296 MTLERERRLL----LRQSQEQWQEKEQRKTLQSPEQRGL------RRDSQRKNVPPGESR 345
LER + +L +RQ + + ++ R +S + G RR Q + +P +S+
Sbjct: 1183 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1242
Query: 346 WKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQL-----QRR 400
+ QE E++E+ E ++CQ K N + + LQL Q
Sbjct: 1243 AVREQLRQEQALLEEIER---HGEKVEECQ-----RFAKQYINAIKDYELQLVTYKAQLE 1294
Query: 401 LVEACRKRHLHAVEGQKKVQD-----TNLSSLINYQARKVLMDCQA----KAEELLRQLS 451
V + K+ + +Q+ T+ S L ++ + + + EE L +
Sbjct: 1295 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1354
Query: 452 LEQSFQRSQEIHQGLRKERQ-------------RELREKAQKE----------------- 481
+ +R E+ L K+RQ RE +E Q+
Sbjct: 1355 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1414
Query: 482 ----EEQLQQARWRAGESEEQRKMRKRILVELA----DEKIRQARSHVHKTTRDKVQHLR 533
+E+LQQ R ++ E+E Q K R+ E + +E+IR R + T R +
Sbjct: 1415 KRSIQEELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1473
Query: 534 ELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQAS 593
EL LR + K + +E+ E ++ ++ + QR + Q + + +A+
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEA--ERLRRQVQDESQRKR---QAEVELASRVKAEAEAA 1528
Query: 594 RREERAPPNSSLDQMVLEAQ 613
R ++RA +L+++ L+A+
Sbjct: 1529 REKQRA--LQALEELRLQAE 1546
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 73.9 bits (180), Expect = 4e-13
Identities = 94/432 (21%), Positives = 193/432 (44%), Gaps = 65/432 (15%)
Query: 214 SSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLK----K 269
S +Q E A+R Q A + R + ++ L +++ ++ + RLK +
Sbjct: 1965 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2024
Query: 270 AQRIRE-LQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQR 328
A+R+RE +Q++A+ + + + QK E+ ++Q +++ Q+ Q++ + R
Sbjct: 2025 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2084
Query: 329 GLRRDSQRKNVPPGESRWKEQPEDQESPRQ----EKLEK-ARAQAEHRKQCQ-----VRR 378
G ++R E+R + + E +S RQ E+L++ A QA+ R Q Q +R+
Sbjct: 2085 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2144
Query: 379 LREQEKMLRNLREQHSLQLQRRLVEACRKRH------------------------LHAVE 414
EQE R EQ +L+ Q++ +A ++H L +
Sbjct: 2145 EAEQEAARRAQAEQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2203
Query: 415 GQKKVQDTNLSSLI---------NYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQG 465
QK + D L L Q + L + + EEL + + ++ R+ +
Sbjct: 2204 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD- 2262
Query: 466 LRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTT 525
+ QR L+E+A+K ++ ++A + ++E ++R +LA+E + Q R+ K
Sbjct: 2263 -KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR-----QLAEEDLAQQRALAEKML 2316
Query: 526 RDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQE 585
++K+Q ++E L+ + + + K +E+ + + KEQ Q +++ Q
Sbjct: 2317 KEKMQAVQEATRLKAEAELLQQQKELAQEQA-----RRLQEDKEQMAQQLAE----ETQG 2367
Query: 586 FQKLPQASRREE 597
FQ+ +A R+ +
Sbjct: 2368 FQRTLEAERQRQ 2379
Score = 72.4 bits (176), Expect = 1e-12
Identities = 85/327 (25%), Positives = 148/327 (45%), Gaps = 40/327 (12%)
Query: 254 SQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQW 313
S ++ VA+ R ++A+R + Q +A +A EE +R ++ Q+ RL L Q++E
Sbjct: 1599 SLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL-QAEEVA 1656
Query: 314 QEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQ 373
Q+K + ++ R+++R+ ++ + + +QE +Q +L + AQ +
Sbjct: 1657 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1716
Query: 374 CQVRRLR---EQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINY 430
++ RLR EQ + R L E+ +LQR A +KR E K +
Sbjct: 1717 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE--------- 1767
Query: 431 QARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARW 490
+VL+ +A+AEE R S E+S QR + R REL E+A AR
Sbjct: 1768 --MEVLLASKARAEEESRSTS-EKSKQRLE-----AEAGRFRELAEEA---------ARL 1810
Query: 491 RAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKA 550
RA E +R+ +LA+E + R+ + +K+ + E L+ + LK K
Sbjct: 1811 RALAEEAKRQR------QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1864
Query: 551 EKEEKCHIEGIKEAIKKK---EQRVQH 574
+ E+ EA +++ EQ QH
Sbjct: 1865 AENERLRRLAEDEAFQRRRLEEQAAQH 1891
Score = 72.4 bits (176), Expect = 1e-12
Identities = 94/422 (22%), Positives = 181/422 (42%), Gaps = 36/422 (8%)
Query: 199 KFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQ- 257
+ K + +K ++++ LA ++ +E + H ++ +L ++ +S +
Sbjct: 1851 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1910
Query: 258 -QIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEK 316
+ LV L++ +++ E + A KA E K + K ++ LE R +R + E
Sbjct: 1911 ERQKGLVEDTLRQRRQVEE-EILALKASFE-KAAAGKAELELELGR---IRSNAEDTLRS 1965
Query: 317 EQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQV 376
+++ L++ QR L + +R+ E K ++E+ RQ K + K +
Sbjct: 1966 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2025
Query: 377 RRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVL 436
RRLRE+ + + Q + + ++ ++A K H AV+ +++ L Q + VL
Sbjct: 2026 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ-----QEQSVL 2080
Query: 437 MDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESE 496
+ +A E R+ + E R Q + + RQ E E+ ++ E+ QAR +A +
Sbjct: 2081 DQLRGEA-EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2139
Query: 497 EQRKMRKRILVE----------------LADEKIRQARSHVHKTTRDKVQHLRELNHLR- 539
E K+RK E AD ++ + + +T R K Q +EL LR
Sbjct: 2140 E--KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2197
Query: 540 --EKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREE 597
E+ H L E+ ++ E EA +++ Q + + + +E KL E
Sbjct: 2198 QLEETDHQKNLLDEELQRLKAEA-TEAARQRSQVEEELFSVR-VQMEELSKLKARIEAEN 2255
Query: 598 RA 599
RA
Sbjct: 2256 RA 2257
Score = 70.5 bits (171), Expect = 4e-12
Identities = 106/495 (21%), Positives = 204/495 (41%), Gaps = 65/495 (13%)
Query: 178 RHLGRWSPSSVPSERSSVPSQKFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRS 237
R L RW + + R + +++ + + A+ ++ E A R + + R
Sbjct: 1633 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1692
Query: 238 PHTQVLKSKLEEVVVSSQDQQIVALVLTRLKK------------AQRIRELQQQAAKAWE 285
Q L+ + + ++Q + L RL+ + + LQ++AA A +
Sbjct: 1693 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1752
Query: 286 ELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQ---------RGLRRDSQR 336
KR + + ++ R +L S+ + E+E R T + +Q R L ++ R
Sbjct: 1753 --KRQELEAELAKVRAEMEVLLASKAR-AEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1809
Query: 337 KNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQC-QVRRLREQEKMLRNLREQHSL 395
E++ + Q ++++ RQ + E R AE + RL+ + ++ +E +
Sbjct: 1810 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1868
Query: 396 QLQRRLV--EACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQ---- 449
+L RRL EA ++R L Q K + + + L + E+ LRQ
Sbjct: 1869 RL-RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1927
Query: 450 ----LSLEQSFQRSQ------EIHQG-LRKERQRELREKAQKEEEQLQQARWRAGESEEQ 498
L+L+ SF+++ E+ G +R + LR K Q E E +Q + A E +
Sbjct: 1928 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1987
Query: 499 RKMRKRILVELA--DEKIRQARSHVHKTTR--DKVQHLRELNHLREKN--------HHIL 546
R+ +R+ LA +E RQ ++ + + R KV+ R L E+
Sbjct: 1988 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2047
Query: 547 KLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREERAPPNSSLD 606
+ + + EEK H A+++KEQ +Q Q + + + +A+RR +
Sbjct: 2048 QKRLQAEEKAH----AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA-----EEAE 2098
Query: 607 QMVLEAQLRACQQNR 621
+ ++A+ A Q R
Sbjct: 2099 EARVQAEREAAQSRR 2113
Score = 67.8 bits (164), Expect = 3e-11
Identities = 101/422 (23%), Positives = 181/422 (42%), Gaps = 63/422 (14%)
Query: 234 EMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKKAQ-RIRELQQQAAKAWEELKRSDQ 292
+ R+ ++LK K++ V +++ + L+ + + AQ + R LQ+ + ++L Q
Sbjct: 2307 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2366
Query: 293 KVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPED 352
Q TLE ER+ L S E + + R S Q D+QR E E+
Sbjct: 2367 GFQRTLEAERQRQLEMSAEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG--EKLHR 2423
Query: 353 QESPRQEK------LEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACR 406
E QEK LE R Q++H RLRE L RE+ LQ + +L++ +
Sbjct: 2424 TELATQEKVTLVQTLEIQRQQSDH----DAERLREAIAELE--REKEKLQQEAKLLQL-K 2476
Query: 407 KRHLHAVEGQKKVQDTNL---------SSLINYQARKVLMDCQAKAEELLR-------QL 450
+ V+ ++ +Q+T SL+ Q + + +AK E+L + QL
Sbjct: 2477 SEEMQTVQQEQLLQETQALQQSFLSEKDSLL--QRERFIEQEKAKLEQLFQDEVAKAQQL 2534
Query: 451 SLEQSFQRSQEIHQGLR--------KERQRELRE---KAQKEEEQLQQARWRAGESEEQR 499
EQ Q+ Q + R + RQ E E + Q+E +QL+Q R + E +
Sbjct: 2535 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE 2594
Query: 500 KMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIE 559
R R ++L +E+ R A +H + T +V + L + R+ + AE E + +
Sbjct: 2595 NQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA---LDGPAAEAEPEHSFD 2651
Query: 560 GIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREERAPPNSSLDQMVLEAQLRACQQ 619
G++ + Q + + + +E Q+L Q ++++D++ +R Q
Sbjct: 2652 GLRRKVS-----AQRLQEAGILSAEELQRLAQG---------HTTVDELARREDVRHYLQ 2697
Query: 620 NR 621
R
Sbjct: 2698 GR 2699
Score = 60.5 bits (145), Expect = 5e-09
Identities = 76/380 (20%), Positives = 174/380 (45%), Gaps = 57/380 (15%)
Query: 210 QKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKK 269
Q+ + ++++L +R + A ++ + ++ + +E S + +Q + +R+K
Sbjct: 1471 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE---SQRKRQAEVELASRVKA 1527
Query: 270 AQRIRELQQQAAKAWEELKRSDQKVQMTLE-------RERRLLLRQSQEQWQEKEQRKTL 322
+Q+A +A EEL+ ++ + L R+ ++ L +Q + + Q K
Sbjct: 1528 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1587
Query: 323 QSPEQRG-LRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLRE 381
E+ L R Q ++V + R + ++ + +Q + E+AR +AE RE
Sbjct: 1588 SFAEKTAQLERSLQEEHVAVAQLR---EEAERRAQQQAEAERAREEAE----------RE 1634
Query: 382 QEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQA 441
E+ L+ +L+L+ + E +++ L E +K+ ++ +AR+ +
Sbjct: 1635 LERW--QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA------EREARR-----RG 1681
Query: 442 KAEE-LLRQLSL-EQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQR 499
KAEE +RQ L EQ ++ +++ +G ++R E++L + R + E+QR
Sbjct: 1682 KAEEQAVRQRELAEQELEKQRQLAEGTAQQR--------LAAEQELIRLRAETEQGEQQR 1733
Query: 500 KMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHIL--KLKAEKEEKCH 557
+L +E++ + + T+ + + EL +R + +L K +AE+E +
Sbjct: 1734 --------QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1785
Query: 558 IEGIKEAIKKKEQRVQHISQ 577
E K+ ++ + R + +++
Sbjct: 1786 SEKSKQRLEAEAGRFRELAE 1805
Score = 52.0 bits (123), Expect = 2e-06
Identities = 60/286 (20%), Positives = 128/286 (44%), Gaps = 12/286 (4%)
Query: 298 LERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPR 357
+E E RL +Q E+ + + + +++ +Q K E++ +Q +E R
Sbjct: 1348 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1407
Query: 358 QEKLEKARAQAEHRKQCQVRRLRE--QEKMLRNLREQHSLQLQR-RLVEACR--KRHLHA 412
+E+ Q + Q ++++LR+ + ++ R+ + + R R+ E R + L A
Sbjct: 1408 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1467
Query: 413 VEGQKKVQDTNLSSL--INYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKER 470
E Q+ + L +L +A Q +AE L RQ+ E +R E+ R +
Sbjct: 1468 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1527
Query: 471 QRELREKAQKEEEQLQQARWRAGESE---EQRKMRKRILVELADEKI-RQARSHVHKTTR 526
+ E + Q+ + L++ R +A E+E Q ++ + V++A E R A + +
Sbjct: 1528 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1587
Query: 527 DKVQHLRELNH-LREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQR 571
+ +L L+E++ + +L+ E E + + E +++ +R
Sbjct: 1588 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1633
Score = 49.3 bits (116), Expect = 1e-05
Identities = 96/469 (20%), Positives = 186/469 (39%), Gaps = 64/469 (13%)
Query: 202 RHSACVCAQKRDSSDQVESLASRDSQPLASSKEMR-----SPHTQVLKSKLEEVVVS-SQ 255
R A A+++ + +VE L ++ A ++++ SP L+S+LE + Q
Sbjct: 1021 RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ 1080
Query: 256 DQQIVALVLTRLKKAQR-IRELQ--QQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQ 312
+ + A+ L +LK IR Q ++ +A EE + Q V TL + +
Sbjct: 1081 VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1140
Query: 313 WQEKEQRKTLQS--PEQRGLRRDSQRKNVPPGE-----SRWKEQPED----------QES 355
Q + Q+ T + E RG + +R GE RW+E+ Q
Sbjct: 1141 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1200
Query: 356 PRQEKLEKARAQAEHRKQC--------QVRRLREQEKMLRNLREQHSLQLQRRLVEACRK 407
RQ +LE+ Q + ++ Q R R+++ L + +++ Q R +A +
Sbjct: 1201 VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE 1260
Query: 408 ---RHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQ 464
RH VE ++ ++++ +Y+ + V Q L S + ++
Sbjct: 1261 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ---------LEPVASPAKKPKVQS 1311
Query: 465 GLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKT 524
G Q + + E +++ SE R+M + +E++ + + +
Sbjct: 1312 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE-------EERLAEQQRAEERE 1364
Query: 525 TRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQ 584
+V+ E + H K +AE+E K + ++E + ++E+ Q K +
Sbjct: 1365 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1424
Query: 585 EFQKLPQASRRE-----------ERAPPNSSLDQMVLEAQLRACQQNRG 622
E Q+L Q+S E ER+ + V+ QL A ++ RG
Sbjct: 1425 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1473
Score = 48.5 bits (114), Expect = 2e-05
Identities = 96/440 (21%), Positives = 183/440 (41%), Gaps = 80/440 (18%)
Query: 238 PHTQVLKSKLEEVVVSSQDQQIVALVLT-RLKKAQRIRE-LQQQAAKAWEELKRSDQKVQ 295
P + K+ L+++ ++ QQ L L+ AQ + E LQQ+ + E++R ++V
Sbjct: 1127 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1186
Query: 296 MTLERERRLL----LRQSQEQWQEKEQRKTLQSPEQRGL------RRDSQRKNVPPGESR 345
LER + +L +RQ + + ++ R +S + G RR Q + +P +S+
Sbjct: 1187 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1246
Query: 346 WKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQL-----QRR 400
+ QE E++E+ E ++CQ K N + + LQL Q
Sbjct: 1247 AVREQLRQEQALLEEIER---HGEKVEECQ-----RFAKQYINAIKDYELQLVTYKAQLE 1298
Query: 401 LVEACRKRHLHAVEGQKKVQD-----TNLSSLINYQARKVLMDCQA----KAEELLRQLS 451
V + K+ + +Q+ T+ S L ++ + + + EE L +
Sbjct: 1299 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1358
Query: 452 LEQSFQRSQEIHQGLRKERQ-------------RELREKAQKE----------------- 481
+ +R E+ L K+RQ RE +E Q+
Sbjct: 1359 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1418
Query: 482 ----EEQLQQARWRAGESEEQRKMRKRILVELA----DEKIRQARSHVHKTTRDKVQHLR 533
+E+LQQ R ++ E+E Q K R+ E + +E+IR R + T R +
Sbjct: 1419 KRSIQEELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1477
Query: 534 ELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQAS 593
EL LR + K + +E+ E ++ ++ + QR + Q + + +A+
Sbjct: 1478 ELQALRARAEEAEAQKRQAQEEA--ERLRRQVQDESQRKR---QAEVELASRVKAEAEAA 1532
Query: 594 RREERAPPNSSLDQMVLEAQ 613
R ++RA +L+++ L+A+
Sbjct: 1533 REKQRA--LQALEELRLQAE 1550
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 73.9 bits (180), Expect = 4e-13
Identities = 94/432 (21%), Positives = 193/432 (44%), Gaps = 65/432 (15%)
Query: 214 SSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLK----K 269
S +Q E A+R Q A + R + ++ L +++ ++ + RLK +
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2020
Query: 270 AQRIRE-LQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQR 328
A+R+RE +Q++A+ + + + QK E+ ++Q +++ Q+ Q++ + R
Sbjct: 2021 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080
Query: 329 GLRRDSQRKNVPPGESRWKEQPEDQESPRQ----EKLEK-ARAQAEHRKQCQ-----VRR 378
G ++R E+R + + E +S RQ E+L++ A QA+ R Q Q +R+
Sbjct: 2081 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2140
Query: 379 LREQEKMLRNLREQHSLQLQRRLVEACRKRH------------------------LHAVE 414
EQE R EQ +L+ Q++ +A ++H L +
Sbjct: 2141 EAEQEAARRAQAEQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199
Query: 415 GQKKVQDTNLSSLI---------NYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQG 465
QK + D L L Q + L + + EEL + + ++ R+ +
Sbjct: 2200 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD- 2258
Query: 466 LRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTT 525
+ QR L+E+A+K ++ ++A + ++E ++R +LA+E + Q R+ K
Sbjct: 2259 -KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR-----QLAEEDLAQQRALAEKML 2312
Query: 526 RDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQE 585
++K+Q ++E L+ + + + K +E+ + + KEQ Q +++ Q
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQA-----RRLQEDKEQMAQQLAE----ETQG 2363
Query: 586 FQKLPQASRREE 597
FQ+ +A R+ +
Sbjct: 2364 FQRTLEAERQRQ 2375
Score = 72.4 bits (176), Expect = 1e-12
Identities = 85/327 (25%), Positives = 148/327 (45%), Gaps = 40/327 (12%)
Query: 254 SQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQW 313
S ++ VA+ R ++A+R + Q +A +A EE +R ++ Q+ RL L Q++E
Sbjct: 1595 SLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL-QAEEVA 1652
Query: 314 QEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQ 373
Q+K + ++ R+++R+ ++ + + +QE +Q +L + AQ +
Sbjct: 1653 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1712
Query: 374 CQVRRLR---EQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINY 430
++ RLR EQ + R L E+ +LQR A +KR E K +
Sbjct: 1713 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE--------- 1763
Query: 431 QARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARW 490
+VL+ +A+AEE R S E+S QR + R REL E+A AR
Sbjct: 1764 --MEVLLASKARAEEESRSTS-EKSKQRLE-----AEAGRFRELAEEA---------ARL 1806
Query: 491 RAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKA 550
RA E +R+ +LA+E + R+ + +K+ + E L+ + LK K
Sbjct: 1807 RALAEEAKRQR------QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1860
Query: 551 EKEEKCHIEGIKEAIKKK---EQRVQH 574
+ E+ EA +++ EQ QH
Sbjct: 1861 AENERLRRLAEDEAFQRRRLEEQAAQH 1887
Score = 72.4 bits (176), Expect = 1e-12
Identities = 94/422 (22%), Positives = 181/422 (42%), Gaps = 36/422 (8%)
Query: 199 KFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQ- 257
+ K + +K ++++ LA ++ +E + H ++ +L ++ +S +
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1906
Query: 258 -QIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEK 316
+ LV L++ +++ E + A KA E K + K ++ LE R +R + E
Sbjct: 1907 ERQKGLVEDTLRQRRQVEE-EILALKASFE-KAAAGKAELELELGR---IRSNAEDTLRS 1961
Query: 317 EQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQV 376
+++ L++ QR L + +R+ E K ++E+ RQ K + K +
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021
Query: 377 RRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVL 436
RRLRE+ + + Q + + ++ ++A K H AV+ +++ L Q + VL
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ-----QEQSVL 2076
Query: 437 MDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESE 496
+ +A E R+ + E R Q + + RQ E E+ ++ E+ QAR +A +
Sbjct: 2077 DQLRGEA-EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2135
Query: 497 EQRKMRKRILVE----------------LADEKIRQARSHVHKTTRDKVQHLRELNHLR- 539
E K+RK E AD ++ + + +T R K Q +EL LR
Sbjct: 2136 E--KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2193
Query: 540 --EKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREE 597
E+ H L E+ ++ E EA +++ Q + + + +E KL E
Sbjct: 2194 QLEETDHQKNLLDEELQRLKAEA-TEAARQRSQVEEELFSVR-VQMEELSKLKARIEAEN 2251
Query: 598 RA 599
RA
Sbjct: 2252 RA 2253
Score = 70.5 bits (171), Expect = 4e-12
Identities = 106/495 (21%), Positives = 204/495 (41%), Gaps = 65/495 (13%)
Query: 178 RHLGRWSPSSVPSERSSVPSQKFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRS 237
R L RW + + R + +++ + + A+ ++ E A R + + R
Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1688
Query: 238 PHTQVLKSKLEEVVVSSQDQQIVALVLTRLKK------------AQRIRELQQQAAKAWE 285
Q L+ + + ++Q + L RL+ + + LQ++AA A +
Sbjct: 1689 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1748
Query: 286 ELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQ---------RGLRRDSQR 336
KR + + ++ R +L S+ + E+E R T + +Q R L ++ R
Sbjct: 1749 --KRQELEAELAKVRAEMEVLLASKAR-AEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1805
Query: 337 KNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQC-QVRRLREQEKMLRNLREQHSL 395
E++ + Q ++++ RQ + E R AE + RL+ + ++ +E +
Sbjct: 1806 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1864
Query: 396 QLQRRLV--EACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQ---- 449
+L RRL EA ++R L Q K + + + L + E+ LRQ
Sbjct: 1865 RL-RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1923
Query: 450 ----LSLEQSFQRSQ------EIHQG-LRKERQRELREKAQKEEEQLQQARWRAGESEEQ 498
L+L+ SF+++ E+ G +R + LR K Q E E +Q + A E +
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1983
Query: 499 RKMRKRILVELA--DEKIRQARSHVHKTTR--DKVQHLRELNHLREKN--------HHIL 546
R+ +R+ LA +E RQ ++ + + R KV+ R L E+
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043
Query: 547 KLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREERAPPNSSLD 606
+ + + EEK H A+++KEQ +Q Q + + + +A+RR +
Sbjct: 2044 QKRLQAEEKAH----AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA-----EEAE 2094
Query: 607 QMVLEAQLRACQQNR 621
+ ++A+ A Q R
Sbjct: 2095 EARVQAEREAAQSRR 2109
Score = 67.8 bits (164), Expect = 3e-11
Identities = 101/422 (23%), Positives = 181/422 (42%), Gaps = 63/422 (14%)
Query: 234 EMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKKAQ-RIRELQQQAAKAWEELKRSDQ 292
+ R+ ++LK K++ V +++ + L+ + + AQ + R LQ+ + ++L Q
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2362
Query: 293 KVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPED 352
Q TLE ER+ L S E + + R S Q D+QR E E+
Sbjct: 2363 GFQRTLEAERQRQLEMSAEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG--EKLHR 2419
Query: 353 QESPRQEK------LEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACR 406
E QEK LE R Q++H RLRE L RE+ LQ + +L++ +
Sbjct: 2420 TELATQEKVTLVQTLEIQRQQSDH----DAERLREAIAELE--REKEKLQQEAKLLQL-K 2472
Query: 407 KRHLHAVEGQKKVQDTNL---------SSLINYQARKVLMDCQAKAEELLR-------QL 450
+ V+ ++ +Q+T SL+ Q + + +AK E+L + QL
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLL--QRERFIEQEKAKLEQLFQDEVAKAQQL 2530
Query: 451 SLEQSFQRSQEIHQGLR--------KERQRELRE---KAQKEEEQLQQARWRAGESEEQR 499
EQ Q+ Q + R + RQ E E + Q+E +QL+Q R + E +
Sbjct: 2531 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE 2590
Query: 500 KMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIE 559
R R ++L +E+ R A +H + T +V + L + R+ + AE E + +
Sbjct: 2591 NQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA---LDGPAAEAEPEHSFD 2647
Query: 560 GIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREERAPPNSSLDQMVLEAQLRACQQ 619
G++ + Q + + + +E Q+L Q ++++D++ +R Q
Sbjct: 2648 GLRRKVS-----AQRLQEAGILSAEELQRLAQG---------HTTVDELARREDVRHYLQ 2693
Query: 620 NR 621
R
Sbjct: 2694 GR 2695
Score = 60.5 bits (145), Expect = 5e-09
Identities = 76/380 (20%), Positives = 174/380 (45%), Gaps = 57/380 (15%)
Query: 210 QKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKK 269
Q+ + ++++L +R + A ++ + ++ + +E S + +Q + +R+K
Sbjct: 1467 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE---SQRKRQAEVELASRVKA 1523
Query: 270 AQRIRELQQQAAKAWEELKRSDQKVQMTLE-------RERRLLLRQSQEQWQEKEQRKTL 322
+Q+A +A EEL+ ++ + L R+ ++ L +Q + + Q K
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1583
Query: 323 QSPEQRG-LRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLRE 381
E+ L R Q ++V + R + ++ + +Q + E+AR +AE RE
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLR---EEAERRAQQQAEAERAREEAE----------RE 1630
Query: 382 QEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQA 441
E+ L+ +L+L+ + E +++ L E +K+ ++ +AR+ +
Sbjct: 1631 LERW--QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA------EREARR-----RG 1677
Query: 442 KAEE-LLRQLSL-EQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQR 499
KAEE +RQ L EQ ++ +++ +G ++R E++L + R + E+QR
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQR--------LAAEQELIRLRAETEQGEQQR 1729
Query: 500 KMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHIL--KLKAEKEEKCH 557
+L +E++ + + T+ + + EL +R + +L K +AE+E +
Sbjct: 1730 --------QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1781
Query: 558 IEGIKEAIKKKEQRVQHISQ 577
E K+ ++ + R + +++
Sbjct: 1782 SEKSKQRLEAEAGRFRELAE 1801
Score = 52.0 bits (123), Expect = 2e-06
Identities = 60/286 (20%), Positives = 128/286 (44%), Gaps = 12/286 (4%)
Query: 298 LERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPR 357
+E E RL +Q E+ + + + +++ +Q K E++ +Q +E R
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 358 QEKLEKARAQAEHRKQCQVRRLRE--QEKMLRNLREQHSLQLQR-RLVEACR--KRHLHA 412
+E+ Q + Q ++++LR+ + ++ R+ + + R R+ E R + L A
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1463
Query: 413 VEGQKKVQDTNLSSL--INYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKER 470
E Q+ + L +L +A Q +AE L RQ+ E +R E+ R +
Sbjct: 1464 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1523
Query: 471 QRELREKAQKEEEQLQQARWRAGESE---EQRKMRKRILVELADEKI-RQARSHVHKTTR 526
+ E + Q+ + L++ R +A E+E Q ++ + V++A E R A + +
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1583
Query: 527 DKVQHLRELNH-LREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQR 571
+ +L L+E++ + +L+ E E + + E +++ +R
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629
Score = 49.3 bits (116), Expect = 1e-05
Identities = 96/469 (20%), Positives = 186/469 (39%), Gaps = 64/469 (13%)
Query: 202 RHSACVCAQKRDSSDQVESLASRDSQPLASSKEMR-----SPHTQVLKSKLEEVVVS-SQ 255
R A A+++ + +VE L ++ A ++++ SP L+S+LE + Q
Sbjct: 1017 RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ 1076
Query: 256 DQQIVALVLTRLKKAQR-IRELQ--QQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQ 312
+ + A+ L +LK IR Q ++ +A EE + Q V TL + +
Sbjct: 1077 VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1136
Query: 313 WQEKEQRKTLQS--PEQRGLRRDSQRKNVPPGE-----SRWKEQPED----------QES 355
Q + Q+ T + E RG + +R GE RW+E+ Q
Sbjct: 1137 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1196
Query: 356 PRQEKLEKARAQAEHRKQC--------QVRRLREQEKMLRNLREQHSLQLQRRLVEACRK 407
RQ +LE+ Q + ++ Q R R+++ L + +++ Q R +A +
Sbjct: 1197 VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE 1256
Query: 408 ---RHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQ 464
RH VE ++ ++++ +Y+ + V Q L S + ++
Sbjct: 1257 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ---------LEPVASPAKKPKVQS 1307
Query: 465 GLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKT 524
G Q + + E +++ SE R+M + +E++ + + +
Sbjct: 1308 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE-------EERLAEQQRAEERE 1360
Query: 525 TRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQ 584
+V+ E + H K +AE+E K + ++E + ++E+ Q K +
Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1420
Query: 585 EFQKLPQASRRE-----------ERAPPNSSLDQMVLEAQLRACQQNRG 622
E Q+L Q+S E ER+ + V+ QL A ++ RG
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1469
Score = 48.5 bits (114), Expect = 2e-05
Identities = 96/440 (21%), Positives = 183/440 (41%), Gaps = 80/440 (18%)
Query: 238 PHTQVLKSKLEEVVVSSQDQQIVALVLT-RLKKAQRIRE-LQQQAAKAWEELKRSDQKVQ 295
P + K+ L+++ ++ QQ L L+ AQ + E LQQ+ + E++R ++V
Sbjct: 1123 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1182
Query: 296 MTLERERRLL----LRQSQEQWQEKEQRKTLQSPEQRGL------RRDSQRKNVPPGESR 345
LER + +L +RQ + + ++ R +S + G RR Q + +P +S+
Sbjct: 1183 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1242
Query: 346 WKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQL-----QRR 400
+ QE E++E+ E ++CQ K N + + LQL Q
Sbjct: 1243 AVREQLRQEQALLEEIER---HGEKVEECQ-----RFAKQYINAIKDYELQLVTYKAQLE 1294
Query: 401 LVEACRKRHLHAVEGQKKVQD-----TNLSSLINYQARKVLMDCQA----KAEELLRQLS 451
V + K+ + +Q+ T+ S L ++ + + + EE L +
Sbjct: 1295 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1354
Query: 452 LEQSFQRSQEIHQGLRKERQ-------------RELREKAQKE----------------- 481
+ +R E+ L K+RQ RE +E Q+
Sbjct: 1355 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1414
Query: 482 ----EEQLQQARWRAGESEEQRKMRKRILVELA----DEKIRQARSHVHKTTRDKVQHLR 533
+E+LQQ R ++ E+E Q K R+ E + +E+IR R + T R +
Sbjct: 1415 KRSIQEELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1473
Query: 534 ELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQAS 593
EL LR + K + +E+ E ++ ++ + QR + Q + + +A+
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEA--ERLRRQVQDESQRKR---QAEVELASRVKAEAEAA 1528
Query: 594 RREERAPPNSSLDQMVLEAQ 613
R ++RA +L+++ L+A+
Sbjct: 1529 REKQRA--LQALEELRLQAE 1546
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 73.9 bits (180), Expect = 4e-13
Identities = 94/432 (21%), Positives = 193/432 (44%), Gaps = 65/432 (15%)
Query: 214 SSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLK----K 269
S +Q E A+R Q A + R + ++ L +++ ++ + RLK +
Sbjct: 1929 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 1988
Query: 270 AQRIRE-LQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQR 328
A+R+RE +Q++A+ + + + QK E+ ++Q +++ Q+ Q++ + R
Sbjct: 1989 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2048
Query: 329 GLRRDSQRKNVPPGESRWKEQPEDQESPRQ----EKLEK-ARAQAEHRKQCQ-----VRR 378
G ++R E+R + + E +S RQ E+L++ A QA+ R Q Q +R+
Sbjct: 2049 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2108
Query: 379 LREQEKMLRNLREQHSLQLQRRLVEACRKRH------------------------LHAVE 414
EQE R EQ +L+ Q++ +A ++H L +
Sbjct: 2109 EAEQEAARRAQAEQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2167
Query: 415 GQKKVQDTNLSSLI---------NYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQG 465
QK + D L L Q + L + + EEL + + ++ R+ +
Sbjct: 2168 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD- 2226
Query: 466 LRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTT 525
+ QR L+E+A+K ++ ++A + ++E ++R +LA+E + Q R+ K
Sbjct: 2227 -KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR-----QLAEEDLAQQRALAEKML 2280
Query: 526 RDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQE 585
++K+Q ++E L+ + + + K +E+ + + KEQ Q +++ Q
Sbjct: 2281 KEKMQAVQEATRLKAEAELLQQQKELAQEQA-----RRLQEDKEQMAQQLAE----ETQG 2331
Query: 586 FQKLPQASRREE 597
FQ+ +A R+ +
Sbjct: 2332 FQRTLEAERQRQ 2343
Score = 72.4 bits (176), Expect = 1e-12
Identities = 85/327 (25%), Positives = 148/327 (45%), Gaps = 40/327 (12%)
Query: 254 SQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQW 313
S ++ VA+ R ++A+R + Q +A +A EE +R ++ Q+ RL L Q++E
Sbjct: 1563 SLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL-QAEEVA 1620
Query: 314 QEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQ 373
Q+K + ++ R+++R+ ++ + + +QE +Q +L + AQ +
Sbjct: 1621 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1680
Query: 374 CQVRRLR---EQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINY 430
++ RLR EQ + R L E+ +LQR A +KR E K +
Sbjct: 1681 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE--------- 1731
Query: 431 QARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARW 490
+VL+ +A+AEE R S E+S QR + R REL E+A AR
Sbjct: 1732 --MEVLLASKARAEEESRSTS-EKSKQRLE-----AEAGRFRELAEEA---------ARL 1774
Query: 491 RAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKA 550
RA E +R+ +LA+E + R+ + +K+ + E L+ + LK K
Sbjct: 1775 RALAEEAKRQR------QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1828
Query: 551 EKEEKCHIEGIKEAIKKK---EQRVQH 574
+ E+ EA +++ EQ QH
Sbjct: 1829 AENERLRRLAEDEAFQRRRLEEQAAQH 1855
Score = 72.4 bits (176), Expect = 1e-12
Identities = 94/422 (22%), Positives = 181/422 (42%), Gaps = 36/422 (8%)
Query: 199 KFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQ- 257
+ K + +K ++++ LA ++ +E + H ++ +L ++ +S +
Sbjct: 1815 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1874
Query: 258 -QIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEK 316
+ LV L++ +++ E + A KA E K + K ++ LE R +R + E
Sbjct: 1875 ERQKGLVEDTLRQRRQVEE-EILALKASFE-KAAAGKAELELELGR---IRSNAEDTLRS 1929
Query: 317 EQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQV 376
+++ L++ QR L + +R+ E K ++E+ RQ K + K +
Sbjct: 1930 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1989
Query: 377 RRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVL 436
RRLRE+ + + Q + + ++ ++A K H AV+ +++ L Q + VL
Sbjct: 1990 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ-----QEQSVL 2044
Query: 437 MDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESE 496
+ +A E R+ + E R Q + + RQ E E+ ++ E+ QAR +A +
Sbjct: 2045 DQLRGEA-EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2103
Query: 497 EQRKMRKRILVE----------------LADEKIRQARSHVHKTTRDKVQHLRELNHLR- 539
E K+RK E AD ++ + + +T R K Q +EL LR
Sbjct: 2104 E--KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2161
Query: 540 --EKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREE 597
E+ H L E+ ++ E EA +++ Q + + + +E KL E
Sbjct: 2162 QLEETDHQKNLLDEELQRLKAEA-TEAARQRSQVEEELFSVR-VQMEELSKLKARIEAEN 2219
Query: 598 RA 599
RA
Sbjct: 2220 RA 2221
Score = 70.5 bits (171), Expect = 4e-12
Identities = 106/495 (21%), Positives = 204/495 (41%), Gaps = 65/495 (13%)
Query: 178 RHLGRWSPSSVPSERSSVPSQKFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRS 237
R L RW + + R + +++ + + A+ ++ E A R + + R
Sbjct: 1597 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1656
Query: 238 PHTQVLKSKLEEVVVSSQDQQIVALVLTRLKK------------AQRIRELQQQAAKAWE 285
Q L+ + + ++Q + L RL+ + + LQ++AA A +
Sbjct: 1657 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1716
Query: 286 ELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQ---------RGLRRDSQR 336
KR + + ++ R +L S+ + E+E R T + +Q R L ++ R
Sbjct: 1717 --KRQELEAELAKVRAEMEVLLASKAR-AEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1773
Query: 337 KNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQC-QVRRLREQEKMLRNLREQHSL 395
E++ + Q ++++ RQ + E R AE + RL+ + ++ +E +
Sbjct: 1774 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1832
Query: 396 QLQRRLV--EACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQ---- 449
+L RRL EA ++R L Q K + + + L + E+ LRQ
Sbjct: 1833 RL-RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1891
Query: 450 ----LSLEQSFQRSQ------EIHQG-LRKERQRELREKAQKEEEQLQQARWRAGESEEQ 498
L+L+ SF+++ E+ G +R + LR K Q E E +Q + A E +
Sbjct: 1892 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1951
Query: 499 RKMRKRILVELA--DEKIRQARSHVHKTTR--DKVQHLRELNHLREKN--------HHIL 546
R+ +R+ LA +E RQ ++ + + R KV+ R L E+
Sbjct: 1952 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2011
Query: 547 KLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREERAPPNSSLD 606
+ + + EEK H A+++KEQ +Q Q + + + +A+RR +
Sbjct: 2012 QKRLQAEEKAH----AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA-----EEAE 2062
Query: 607 QMVLEAQLRACQQNR 621
+ ++A+ A Q R
Sbjct: 2063 EARVQAEREAAQSRR 2077
Score = 67.8 bits (164), Expect = 3e-11
Identities = 101/422 (23%), Positives = 181/422 (42%), Gaps = 63/422 (14%)
Query: 234 EMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKKAQ-RIRELQQQAAKAWEELKRSDQ 292
+ R+ ++LK K++ V +++ + L+ + + AQ + R LQ+ + ++L Q
Sbjct: 2271 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2330
Query: 293 KVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPED 352
Q TLE ER+ L S E + + R S Q D+QR E E+
Sbjct: 2331 GFQRTLEAERQRQLEMSAEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG--EKLHR 2387
Query: 353 QESPRQEK------LEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACR 406
E QEK LE R Q++H RLRE L RE+ LQ + +L++ +
Sbjct: 2388 TELATQEKVTLVQTLEIQRQQSDH----DAERLREAIAELE--REKEKLQQEAKLLQL-K 2440
Query: 407 KRHLHAVEGQKKVQDTNL---------SSLINYQARKVLMDCQAKAEELLR-------QL 450
+ V+ ++ +Q+T SL+ Q + + +AK E+L + QL
Sbjct: 2441 SEEMQTVQQEQLLQETQALQQSFLSEKDSLL--QRERFIEQEKAKLEQLFQDEVAKAQQL 2498
Query: 451 SLEQSFQRSQEIHQGLR--------KERQRELRE---KAQKEEEQLQQARWRAGESEEQR 499
EQ Q+ Q + R + RQ E E + Q+E +QL+Q R + E +
Sbjct: 2499 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE 2558
Query: 500 KMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIE 559
R R ++L +E+ R A +H + T +V + L + R+ + AE E + +
Sbjct: 2559 NQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA---LDGPAAEAEPEHSFD 2615
Query: 560 GIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREERAPPNSSLDQMVLEAQLRACQQ 619
G++ + Q + + + +E Q+L Q ++++D++ +R Q
Sbjct: 2616 GLRRKVS-----AQRLQEAGILSAEELQRLAQG---------HTTVDELARREDVRHYLQ 2661
Query: 620 NR 621
R
Sbjct: 2662 GR 2663
Score = 60.5 bits (145), Expect = 5e-09
Identities = 76/380 (20%), Positives = 174/380 (45%), Gaps = 57/380 (15%)
Query: 210 QKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKK 269
Q+ + ++++L +R + A ++ + ++ + +E S + +Q + +R+K
Sbjct: 1435 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE---SQRKRQAEVELASRVKA 1491
Query: 270 AQRIRELQQQAAKAWEELKRSDQKVQMTLE-------RERRLLLRQSQEQWQEKEQRKTL 322
+Q+A +A EEL+ ++ + L R+ ++ L +Q + + Q K
Sbjct: 1492 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1551
Query: 323 QSPEQRG-LRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLRE 381
E+ L R Q ++V + R + ++ + +Q + E+AR +AE RE
Sbjct: 1552 SFAEKTAQLERSLQEEHVAVAQLR---EEAERRAQQQAEAERAREEAE----------RE 1598
Query: 382 QEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQA 441
E+ L+ +L+L+ + E +++ L E +K+ ++ +AR+ +
Sbjct: 1599 LERW--QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA------EREARR-----RG 1645
Query: 442 KAEE-LLRQLSL-EQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQR 499
KAEE +RQ L EQ ++ +++ +G ++R E++L + R + E+QR
Sbjct: 1646 KAEEQAVRQRELAEQELEKQRQLAEGTAQQR--------LAAEQELIRLRAETEQGEQQR 1697
Query: 500 KMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHIL--KLKAEKEEKCH 557
+L +E++ + + T+ + + EL +R + +L K +AE+E +
Sbjct: 1698 --------QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1749
Query: 558 IEGIKEAIKKKEQRVQHISQ 577
E K+ ++ + R + +++
Sbjct: 1750 SEKSKQRLEAEAGRFRELAE 1769
Score = 52.0 bits (123), Expect = 2e-06
Identities = 60/286 (20%), Positives = 128/286 (44%), Gaps = 12/286 (4%)
Query: 298 LERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPR 357
+E E RL +Q E+ + + + +++ +Q K E++ +Q +E R
Sbjct: 1312 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1371
Query: 358 QEKLEKARAQAEHRKQCQVRRLRE--QEKMLRNLREQHSLQLQR-RLVEACR--KRHLHA 412
+E+ Q + Q ++++LR+ + ++ R+ + + R R+ E R + L A
Sbjct: 1372 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1431
Query: 413 VEGQKKVQDTNLSSL--INYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKER 470
E Q+ + L +L +A Q +AE L RQ+ E +R E+ R +
Sbjct: 1432 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1491
Query: 471 QRELREKAQKEEEQLQQARWRAGESE---EQRKMRKRILVELADEKI-RQARSHVHKTTR 526
+ E + Q+ + L++ R +A E+E Q ++ + V++A E R A + +
Sbjct: 1492 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1551
Query: 527 DKVQHLRELNH-LREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQR 571
+ +L L+E++ + +L+ E E + + E +++ +R
Sbjct: 1552 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1597
Score = 49.3 bits (116), Expect = 1e-05
Identities = 96/469 (20%), Positives = 186/469 (39%), Gaps = 64/469 (13%)
Query: 202 RHSACVCAQKRDSSDQVESLASRDSQPLASSKEMR-----SPHTQVLKSKLEEVVVS-SQ 255
R A A+++ + +VE L ++ A ++++ SP L+S+LE + Q
Sbjct: 985 RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ 1044
Query: 256 DQQIVALVLTRLKKAQR-IRELQ--QQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQ 312
+ + A+ L +LK IR Q ++ +A EE + Q V TL + +
Sbjct: 1045 VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1104
Query: 313 WQEKEQRKTLQS--PEQRGLRRDSQRKNVPPGE-----SRWKEQPED----------QES 355
Q + Q+ T + E RG + +R GE RW+E+ Q
Sbjct: 1105 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1164
Query: 356 PRQEKLEKARAQAEHRKQC--------QVRRLREQEKMLRNLREQHSLQLQRRLVEACRK 407
RQ +LE+ Q + ++ Q R R+++ L + +++ Q R +A +
Sbjct: 1165 VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE 1224
Query: 408 ---RHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQ 464
RH VE ++ ++++ +Y+ + V Q L S + ++
Sbjct: 1225 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ---------LEPVASPAKKPKVQS 1275
Query: 465 GLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKT 524
G Q + + E +++ SE R+M + +E++ + + +
Sbjct: 1276 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE-------EERLAEQQRAEERE 1328
Query: 525 TRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQ 584
+V+ E + H K +AE+E K + ++E + ++E+ Q K +
Sbjct: 1329 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1388
Query: 585 EFQKLPQASRRE-----------ERAPPNSSLDQMVLEAQLRACQQNRG 622
E Q+L Q+S E ER+ + V+ QL A ++ RG
Sbjct: 1389 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1437
Score = 48.5 bits (114), Expect = 2e-05
Identities = 96/440 (21%), Positives = 183/440 (41%), Gaps = 80/440 (18%)
Query: 238 PHTQVLKSKLEEVVVSSQDQQIVALVLT-RLKKAQRIRE-LQQQAAKAWEELKRSDQKVQ 295
P + K+ L+++ ++ QQ L L+ AQ + E LQQ+ + E++R ++V
Sbjct: 1091 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1150
Query: 296 MTLERERRLL----LRQSQEQWQEKEQRKTLQSPEQRGL------RRDSQRKNVPPGESR 345
LER + +L +RQ + + ++ R +S + G RR Q + +P +S+
Sbjct: 1151 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1210
Query: 346 WKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQL-----QRR 400
+ QE E++E+ E ++CQ K N + + LQL Q
Sbjct: 1211 AVREQLRQEQALLEEIER---HGEKVEECQ-----RFAKQYINAIKDYELQLVTYKAQLE 1262
Query: 401 LVEACRKRHLHAVEGQKKVQD-----TNLSSLINYQARKVLMDCQA----KAEELLRQLS 451
V + K+ + +Q+ T+ S L ++ + + + EE L +
Sbjct: 1263 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1322
Query: 452 LEQSFQRSQEIHQGLRKERQ-------------RELREKAQKE----------------- 481
+ +R E+ L K+RQ RE +E Q+
Sbjct: 1323 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1382
Query: 482 ----EEQLQQARWRAGESEEQRKMRKRILVELA----DEKIRQARSHVHKTTRDKVQHLR 533
+E+LQQ R ++ E+E Q K R+ E + +E+IR R + T R +
Sbjct: 1383 KRSIQEELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1441
Query: 534 ELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQAS 593
EL LR + K + +E+ E ++ ++ + QR + Q + + +A+
Sbjct: 1442 ELQALRARAEEAEAQKRQAQEEA--ERLRRQVQDESQRKR---QAEVELASRVKAEAEAA 1496
Query: 594 RREERAPPNSSLDQMVLEAQ 613
R ++RA +L+++ L+A+
Sbjct: 1497 REKQRA--LQALEELRLQAE 1514
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 73.9 bits (180), Expect = 4e-13
Identities = 94/432 (21%), Positives = 193/432 (44%), Gaps = 65/432 (15%)
Query: 214 SSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLK----K 269
S +Q E A+R Q A + R + ++ L +++ ++ + RLK +
Sbjct: 2098 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2157
Query: 270 AQRIRE-LQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQR 328
A+R+RE +Q++A+ + + + QK E+ ++Q +++ Q+ Q++ + R
Sbjct: 2158 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2217
Query: 329 GLRRDSQRKNVPPGESRWKEQPEDQESPRQ----EKLEK-ARAQAEHRKQCQ-----VRR 378
G ++R E+R + + E +S RQ E+L++ A QA+ R Q Q +R+
Sbjct: 2218 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2277
Query: 379 LREQEKMLRNLREQHSLQLQRRLVEACRKRH------------------------LHAVE 414
EQE R EQ +L+ Q++ +A ++H L +
Sbjct: 2278 EAEQEAARRAQAEQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2336
Query: 415 GQKKVQDTNLSSLI---------NYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQG 465
QK + D L L Q + L + + EEL + + ++ R+ +
Sbjct: 2337 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD- 2395
Query: 466 LRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTT 525
+ QR L+E+A+K ++ ++A + ++E ++R +LA+E + Q R+ K
Sbjct: 2396 -KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR-----QLAEEDLAQQRALAEKML 2449
Query: 526 RDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQE 585
++K+Q ++E L+ + + + K +E+ + + KEQ Q +++ Q
Sbjct: 2450 KEKMQAVQEATRLKAEAELLQQQKELAQEQA-----RRLQEDKEQMAQQLAE----ETQG 2500
Query: 586 FQKLPQASRREE 597
FQ+ +A R+ +
Sbjct: 2501 FQRTLEAERQRQ 2512
Score = 72.4 bits (176), Expect = 1e-12
Identities = 85/327 (25%), Positives = 148/327 (45%), Gaps = 40/327 (12%)
Query: 254 SQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQW 313
S ++ VA+ R ++A+R + Q +A +A EE +R ++ Q+ RL L Q++E
Sbjct: 1732 SLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL-QAEEVA 1789
Query: 314 QEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQ 373
Q+K + ++ R+++R+ ++ + + +QE +Q +L + AQ +
Sbjct: 1790 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1849
Query: 374 CQVRRLR---EQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINY 430
++ RLR EQ + R L E+ +LQR A +KR E K +
Sbjct: 1850 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE--------- 1900
Query: 431 QARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARW 490
+VL+ +A+AEE R S E+S QR + R REL E+A AR
Sbjct: 1901 --MEVLLASKARAEEESRSTS-EKSKQRLE-----AEAGRFRELAEEA---------ARL 1943
Query: 491 RAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKA 550
RA E +R+ +LA+E + R+ + +K+ + E L+ + LK K
Sbjct: 1944 RALAEEAKRQR------QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1997
Query: 551 EKEEKCHIEGIKEAIKKK---EQRVQH 574
+ E+ EA +++ EQ QH
Sbjct: 1998 AENERLRRLAEDEAFQRRRLEEQAAQH 2024
Score = 72.4 bits (176), Expect = 1e-12
Identities = 94/422 (22%), Positives = 181/422 (42%), Gaps = 36/422 (8%)
Query: 199 KFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQ- 257
+ K + +K ++++ LA ++ +E + H ++ +L ++ +S +
Sbjct: 1984 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 2043
Query: 258 -QIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEK 316
+ LV L++ +++ E + A KA E K + K ++ LE R +R + E
Sbjct: 2044 ERQKGLVEDTLRQRRQVEE-EILALKASFE-KAAAGKAELELELGR---IRSNAEDTLRS 2098
Query: 317 EQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQV 376
+++ L++ QR L + +R+ E K ++E+ RQ K + K +
Sbjct: 2099 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2158
Query: 377 RRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVL 436
RRLRE+ + + Q + + ++ ++A K H AV+ +++ L Q + VL
Sbjct: 2159 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ-----QEQSVL 2213
Query: 437 MDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESE 496
+ +A E R+ + E R Q + + RQ E E+ ++ E+ QAR +A +
Sbjct: 2214 DQLRGEA-EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2272
Query: 497 EQRKMRKRILVE----------------LADEKIRQARSHVHKTTRDKVQHLRELNHLR- 539
E K+RK E AD ++ + + +T R K Q +EL LR
Sbjct: 2273 E--KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2330
Query: 540 --EKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREE 597
E+ H L E+ ++ E EA +++ Q + + + +E KL E
Sbjct: 2331 QLEETDHQKNLLDEELQRLKAEA-TEAARQRSQVEEELFSVR-VQMEELSKLKARIEAEN 2388
Query: 598 RA 599
RA
Sbjct: 2389 RA 2390
Score = 70.5 bits (171), Expect = 4e-12
Identities = 106/495 (21%), Positives = 204/495 (41%), Gaps = 65/495 (13%)
Query: 178 RHLGRWSPSSVPSERSSVPSQKFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRS 237
R L RW + + R + +++ + + A+ ++ E A R + + R
Sbjct: 1766 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1825
Query: 238 PHTQVLKSKLEEVVVSSQDQQIVALVLTRLKK------------AQRIRELQQQAAKAWE 285
Q L+ + + ++Q + L RL+ + + LQ++AA A +
Sbjct: 1826 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1885
Query: 286 ELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQ---------RGLRRDSQR 336
KR + + ++ R +L S+ + E+E R T + +Q R L ++ R
Sbjct: 1886 --KRQELEAELAKVRAEMEVLLASKAR-AEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1942
Query: 337 KNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQC-QVRRLREQEKMLRNLREQHSL 395
E++ + Q ++++ RQ + E R AE + RL+ + ++ +E +
Sbjct: 1943 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 2001
Query: 396 QLQRRLV--EACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQ---- 449
+L RRL EA ++R L Q K + + + L + E+ LRQ
Sbjct: 2002 RL-RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 2060
Query: 450 ----LSLEQSFQRSQ------EIHQG-LRKERQRELREKAQKEEEQLQQARWRAGESEEQ 498
L+L+ SF+++ E+ G +R + LR K Q E E +Q + A E +
Sbjct: 2061 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 2120
Query: 499 RKMRKRILVELA--DEKIRQARSHVHKTTR--DKVQHLRELNHLREKN--------HHIL 546
R+ +R+ LA +E RQ ++ + + R KV+ R L E+
Sbjct: 2121 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2180
Query: 547 KLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREERAPPNSSLD 606
+ + + EEK H A+++KEQ +Q Q + + + +A+RR +
Sbjct: 2181 QKRLQAEEKAH----AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA-----EEAE 2231
Query: 607 QMVLEAQLRACQQNR 621
+ ++A+ A Q R
Sbjct: 2232 EARVQAEREAAQSRR 2246
Score = 67.8 bits (164), Expect = 3e-11
Identities = 101/422 (23%), Positives = 181/422 (42%), Gaps = 63/422 (14%)
Query: 234 EMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKKAQ-RIRELQQQAAKAWEELKRSDQ 292
+ R+ ++LK K++ V +++ + L+ + + AQ + R LQ+ + ++L Q
Sbjct: 2440 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2499
Query: 293 KVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPED 352
Q TLE ER+ L S E + + R S Q D+QR E E+
Sbjct: 2500 GFQRTLEAERQRQLEMSAEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG--EKLHR 2556
Query: 353 QESPRQEK------LEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACR 406
E QEK LE R Q++H RLRE L RE+ LQ + +L++ +
Sbjct: 2557 TELATQEKVTLVQTLEIQRQQSDH----DAERLREAIAELE--REKEKLQQEAKLLQL-K 2609
Query: 407 KRHLHAVEGQKKVQDTNL---------SSLINYQARKVLMDCQAKAEELLR-------QL 450
+ V+ ++ +Q+T SL+ Q + + +AK E+L + QL
Sbjct: 2610 SEEMQTVQQEQLLQETQALQQSFLSEKDSLL--QRERFIEQEKAKLEQLFQDEVAKAQQL 2667
Query: 451 SLEQSFQRSQEIHQGLR--------KERQRELRE---KAQKEEEQLQQARWRAGESEEQR 499
EQ Q+ Q + R + RQ E E + Q+E +QL+Q R + E +
Sbjct: 2668 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE 2727
Query: 500 KMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIE 559
R R ++L +E+ R A +H + T +V + L + R+ + AE E + +
Sbjct: 2728 NQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA---LDGPAAEAEPEHSFD 2784
Query: 560 GIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREERAPPNSSLDQMVLEAQLRACQQ 619
G++ + Q + + + +E Q+L Q ++++D++ +R Q
Sbjct: 2785 GLRRKVS-----AQRLQEAGILSAEELQRLAQG---------HTTVDELARREDVRHYLQ 2830
Query: 620 NR 621
R
Sbjct: 2831 GR 2832
Score = 60.5 bits (145), Expect = 5e-09
Identities = 76/380 (20%), Positives = 174/380 (45%), Gaps = 57/380 (15%)
Query: 210 QKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKK 269
Q+ + ++++L +R + A ++ + ++ + +E S + +Q + +R+K
Sbjct: 1604 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE---SQRKRQAEVELASRVKA 1660
Query: 270 AQRIRELQQQAAKAWEELKRSDQKVQMTLE-------RERRLLLRQSQEQWQEKEQRKTL 322
+Q+A +A EEL+ ++ + L R+ ++ L +Q + + Q K
Sbjct: 1661 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1720
Query: 323 QSPEQRG-LRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLRE 381
E+ L R Q ++V + R + ++ + +Q + E+AR +AE RE
Sbjct: 1721 SFAEKTAQLERSLQEEHVAVAQLR---EEAERRAQQQAEAERAREEAE----------RE 1767
Query: 382 QEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQA 441
E+ L+ +L+L+ + E +++ L E +K+ ++ +AR+ +
Sbjct: 1768 LERW--QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA------EREARR-----RG 1814
Query: 442 KAEE-LLRQLSL-EQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQR 499
KAEE +RQ L EQ ++ +++ +G ++R E++L + R + E+QR
Sbjct: 1815 KAEEQAVRQRELAEQELEKQRQLAEGTAQQR--------LAAEQELIRLRAETEQGEQQR 1866
Query: 500 KMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHIL--KLKAEKEEKCH 557
+L +E++ + + T+ + + EL +R + +L K +AE+E +
Sbjct: 1867 --------QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1918
Query: 558 IEGIKEAIKKKEQRVQHISQ 577
E K+ ++ + R + +++
Sbjct: 1919 SEKSKQRLEAEAGRFRELAE 1938
Score = 52.0 bits (123), Expect = 2e-06
Identities = 60/286 (20%), Positives = 128/286 (44%), Gaps = 12/286 (4%)
Query: 298 LERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPR 357
+E E RL +Q E+ + + + +++ +Q K E++ +Q +E R
Sbjct: 1481 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1540
Query: 358 QEKLEKARAQAEHRKQCQVRRLRE--QEKMLRNLREQHSLQLQR-RLVEACR--KRHLHA 412
+E+ Q + Q ++++LR+ + ++ R+ + + R R+ E R + L A
Sbjct: 1541 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1600
Query: 413 VEGQKKVQDTNLSSL--INYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKER 470
E Q+ + L +L +A Q +AE L RQ+ E +R E+ R +
Sbjct: 1601 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1660
Query: 471 QRELREKAQKEEEQLQQARWRAGESE---EQRKMRKRILVELADEKI-RQARSHVHKTTR 526
+ E + Q+ + L++ R +A E+E Q ++ + V++A E R A + +
Sbjct: 1661 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1720
Query: 527 DKVQHLRELNH-LREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQR 571
+ +L L+E++ + +L+ E E + + E +++ +R
Sbjct: 1721 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1766
Score = 49.3 bits (116), Expect = 1e-05
Identities = 96/469 (20%), Positives = 186/469 (39%), Gaps = 64/469 (13%)
Query: 202 RHSACVCAQKRDSSDQVESLASRDSQPLASSKEMR-----SPHTQVLKSKLEEVVVS-SQ 255
R A A+++ + +VE L ++ A ++++ SP L+S+LE + Q
Sbjct: 1154 RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ 1213
Query: 256 DQQIVALVLTRLKKAQR-IRELQ--QQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQ 312
+ + A+ L +LK IR Q ++ +A EE + Q V TL + +
Sbjct: 1214 VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1273
Query: 313 WQEKEQRKTLQS--PEQRGLRRDSQRKNVPPGE-----SRWKEQPED----------QES 355
Q + Q+ T + E RG + +R GE RW+E+ Q
Sbjct: 1274 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1333
Query: 356 PRQEKLEKARAQAEHRKQC--------QVRRLREQEKMLRNLREQHSLQLQRRLVEACRK 407
RQ +LE+ Q + ++ Q R R+++ L + +++ Q R +A +
Sbjct: 1334 VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE 1393
Query: 408 ---RHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQ 464
RH VE ++ ++++ +Y+ + V Q L S + ++
Sbjct: 1394 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ---------LEPVASPAKKPKVQS 1444
Query: 465 GLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKT 524
G Q + + E +++ SE R+M + +E++ + + +
Sbjct: 1445 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE-------EERLAEQQRAEERE 1497
Query: 525 TRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQ 584
+V+ E + H K +AE+E K + ++E + ++E+ Q K +
Sbjct: 1498 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1557
Query: 585 EFQKLPQASRRE-----------ERAPPNSSLDQMVLEAQLRACQQNRG 622
E Q+L Q+S E ER+ + V+ QL A ++ RG
Sbjct: 1558 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1606
Score = 48.5 bits (114), Expect = 2e-05
Identities = 96/440 (21%), Positives = 183/440 (41%), Gaps = 80/440 (18%)
Query: 238 PHTQVLKSKLEEVVVSSQDQQIVALVLT-RLKKAQRIRE-LQQQAAKAWEELKRSDQKVQ 295
P + K+ L+++ ++ QQ L L+ AQ + E LQQ+ + E++R ++V
Sbjct: 1260 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1319
Query: 296 MTLERERRLL----LRQSQEQWQEKEQRKTLQSPEQRGL------RRDSQRKNVPPGESR 345
LER + +L +RQ + + ++ R +S + G RR Q + +P +S+
Sbjct: 1320 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1379
Query: 346 WKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQL-----QRR 400
+ QE E++E+ E ++CQ K N + + LQL Q
Sbjct: 1380 AVREQLRQEQALLEEIER---HGEKVEECQ-----RFAKQYINAIKDYELQLVTYKAQLE 1431
Query: 401 LVEACRKRHLHAVEGQKKVQD-----TNLSSLINYQARKVLMDCQA----KAEELLRQLS 451
V + K+ + +Q+ T+ S L ++ + + + EE L +
Sbjct: 1432 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1491
Query: 452 LEQSFQRSQEIHQGLRKERQ-------------RELREKAQKE----------------- 481
+ +R E+ L K+RQ RE +E Q+
Sbjct: 1492 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1551
Query: 482 ----EEQLQQARWRAGESEEQRKMRKRILVELA----DEKIRQARSHVHKTTRDKVQHLR 533
+E+LQQ R ++ E+E Q K R+ E + +E+IR R + T R +
Sbjct: 1552 KRSIQEELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1610
Query: 534 ELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQAS 593
EL LR + K + +E+ E ++ ++ + QR + Q + + +A+
Sbjct: 1611 ELQALRARAEEAEAQKRQAQEEA--ERLRRQVQDESQRKR---QAEVELASRVKAEAEAA 1665
Query: 594 RREERAPPNSSLDQMVLEAQ 613
R ++RA +L+++ L+A+
Sbjct: 1666 REKQRA--LQALEELRLQAE 1683
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 73.9 bits (180), Expect = 4e-13
Identities = 94/432 (21%), Positives = 193/432 (44%), Gaps = 65/432 (15%)
Query: 214 SSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLK----K 269
S +Q E A+R Q A + R + ++ L +++ ++ + RLK +
Sbjct: 1939 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 1998
Query: 270 AQRIRE-LQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQR 328
A+R+RE +Q++A+ + + + QK E+ ++Q +++ Q+ Q++ + R
Sbjct: 1999 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2058
Query: 329 GLRRDSQRKNVPPGESRWKEQPEDQESPRQ----EKLEK-ARAQAEHRKQCQ-----VRR 378
G ++R E+R + + E +S RQ E+L++ A QA+ R Q Q +R+
Sbjct: 2059 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2118
Query: 379 LREQEKMLRNLREQHSLQLQRRLVEACRKRH------------------------LHAVE 414
EQE R EQ +L+ Q++ +A ++H L +
Sbjct: 2119 EAEQEAARRAQAEQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2177
Query: 415 GQKKVQDTNLSSLI---------NYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQG 465
QK + D L L Q + L + + EEL + + ++ R+ +
Sbjct: 2178 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD- 2236
Query: 466 LRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTT 525
+ QR L+E+A+K ++ ++A + ++E ++R +LA+E + Q R+ K
Sbjct: 2237 -KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR-----QLAEEDLAQQRALAEKML 2290
Query: 526 RDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQE 585
++K+Q ++E L+ + + + K +E+ + + KEQ Q +++ Q
Sbjct: 2291 KEKMQAVQEATRLKAEAELLQQQKELAQEQA-----RRLQEDKEQMAQQLAE----ETQG 2341
Query: 586 FQKLPQASRREE 597
FQ+ +A R+ +
Sbjct: 2342 FQRTLEAERQRQ 2353
Score = 72.4 bits (176), Expect = 1e-12
Identities = 85/327 (25%), Positives = 148/327 (45%), Gaps = 40/327 (12%)
Query: 254 SQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQW 313
S ++ VA+ R ++A+R + Q +A +A EE +R ++ Q+ RL L Q++E
Sbjct: 1573 SLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL-QAEEVA 1630
Query: 314 QEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQ 373
Q+K + ++ R+++R+ ++ + + +QE +Q +L + AQ +
Sbjct: 1631 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1690
Query: 374 CQVRRLR---EQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINY 430
++ RLR EQ + R L E+ +LQR A +KR E K +
Sbjct: 1691 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE--------- 1741
Query: 431 QARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARW 490
+VL+ +A+AEE R S E+S QR + R REL E+A AR
Sbjct: 1742 --MEVLLASKARAEEESRSTS-EKSKQRLE-----AEAGRFRELAEEA---------ARL 1784
Query: 491 RAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKA 550
RA E +R+ +LA+E + R+ + +K+ + E L+ + LK K
Sbjct: 1785 RALAEEAKRQR------QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1838
Query: 551 EKEEKCHIEGIKEAIKKK---EQRVQH 574
+ E+ EA +++ EQ QH
Sbjct: 1839 AENERLRRLAEDEAFQRRRLEEQAAQH 1865
Score = 72.4 bits (176), Expect = 1e-12
Identities = 94/422 (22%), Positives = 181/422 (42%), Gaps = 36/422 (8%)
Query: 199 KFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQ- 257
+ K + +K ++++ LA ++ +E + H ++ +L ++ +S +
Sbjct: 1825 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1884
Query: 258 -QIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEK 316
+ LV L++ +++ E + A KA E K + K ++ LE R +R + E
Sbjct: 1885 ERQKGLVEDTLRQRRQVEE-EILALKASFE-KAAAGKAELELELGR---IRSNAEDTLRS 1939
Query: 317 EQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQV 376
+++ L++ QR L + +R+ E K ++E+ RQ K + K +
Sbjct: 1940 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1999
Query: 377 RRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVL 436
RRLRE+ + + Q + + ++ ++A K H AV+ +++ L Q + VL
Sbjct: 2000 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ-----QEQSVL 2054
Query: 437 MDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESE 496
+ +A E R+ + E R Q + + RQ E E+ ++ E+ QAR +A +
Sbjct: 2055 DQLRGEA-EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2113
Query: 497 EQRKMRKRILVE----------------LADEKIRQARSHVHKTTRDKVQHLRELNHLR- 539
E K+RK E AD ++ + + +T R K Q +EL LR
Sbjct: 2114 E--KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2171
Query: 540 --EKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREE 597
E+ H L E+ ++ E EA +++ Q + + + +E KL E
Sbjct: 2172 QLEETDHQKNLLDEELQRLKAEA-TEAARQRSQVEEELFSVR-VQMEELSKLKARIEAEN 2229
Query: 598 RA 599
RA
Sbjct: 2230 RA 2231
Score = 70.5 bits (171), Expect = 4e-12
Identities = 106/495 (21%), Positives = 204/495 (41%), Gaps = 65/495 (13%)
Query: 178 RHLGRWSPSSVPSERSSVPSQKFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRS 237
R L RW + + R + +++ + + A+ ++ E A R + + R
Sbjct: 1607 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1666
Query: 238 PHTQVLKSKLEEVVVSSQDQQIVALVLTRLKK------------AQRIRELQQQAAKAWE 285
Q L+ + + ++Q + L RL+ + + LQ++AA A +
Sbjct: 1667 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1726
Query: 286 ELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQ---------RGLRRDSQR 336
KR + + ++ R +L S+ + E+E R T + +Q R L ++ R
Sbjct: 1727 --KRQELEAELAKVRAEMEVLLASKAR-AEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1783
Query: 337 KNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQC-QVRRLREQEKMLRNLREQHSL 395
E++ + Q ++++ RQ + E R AE + RL+ + ++ +E +
Sbjct: 1784 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1842
Query: 396 QLQRRLV--EACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQ---- 449
+L RRL EA ++R L Q K + + + L + E+ LRQ
Sbjct: 1843 RL-RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1901
Query: 450 ----LSLEQSFQRSQ------EIHQG-LRKERQRELREKAQKEEEQLQQARWRAGESEEQ 498
L+L+ SF+++ E+ G +R + LR K Q E E +Q + A E +
Sbjct: 1902 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1961
Query: 499 RKMRKRILVELA--DEKIRQARSHVHKTTR--DKVQHLRELNHLREKN--------HHIL 546
R+ +R+ LA +E RQ ++ + + R KV+ R L E+
Sbjct: 1962 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2021
Query: 547 KLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREERAPPNSSLD 606
+ + + EEK H A+++KEQ +Q Q + + + +A+RR +
Sbjct: 2022 QKRLQAEEKAH----AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA-----EEAE 2072
Query: 607 QMVLEAQLRACQQNR 621
+ ++A+ A Q R
Sbjct: 2073 EARVQAEREAAQSRR 2087
Score = 67.8 bits (164), Expect = 3e-11
Identities = 101/422 (23%), Positives = 181/422 (42%), Gaps = 63/422 (14%)
Query: 234 EMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKKAQ-RIRELQQQAAKAWEELKRSDQ 292
+ R+ ++LK K++ V +++ + L+ + + AQ + R LQ+ + ++L Q
Sbjct: 2281 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2340
Query: 293 KVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPED 352
Q TLE ER+ L S E + + R S Q D+QR E E+
Sbjct: 2341 GFQRTLEAERQRQLEMSAEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG--EKLHR 2397
Query: 353 QESPRQEK------LEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACR 406
E QEK LE R Q++H RLRE L RE+ LQ + +L++ +
Sbjct: 2398 TELATQEKVTLVQTLEIQRQQSDH----DAERLREAIAELE--REKEKLQQEAKLLQL-K 2450
Query: 407 KRHLHAVEGQKKVQDTNL---------SSLINYQARKVLMDCQAKAEELLR-------QL 450
+ V+ ++ +Q+T SL+ Q + + +AK E+L + QL
Sbjct: 2451 SEEMQTVQQEQLLQETQALQQSFLSEKDSLL--QRERFIEQEKAKLEQLFQDEVAKAQQL 2508
Query: 451 SLEQSFQRSQEIHQGLR--------KERQRELRE---KAQKEEEQLQQARWRAGESEEQR 499
EQ Q+ Q + R + RQ E E + Q+E +QL+Q R + E +
Sbjct: 2509 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE 2568
Query: 500 KMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIE 559
R R ++L +E+ R A +H + T +V + L + R+ + AE E + +
Sbjct: 2569 NQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA---LDGPAAEAEPEHSFD 2625
Query: 560 GIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREERAPPNSSLDQMVLEAQLRACQQ 619
G++ + Q + + + +E Q+L Q ++++D++ +R Q
Sbjct: 2626 GLRRKVS-----AQRLQEAGILSAEELQRLAQG---------HTTVDELARREDVRHYLQ 2671
Query: 620 NR 621
R
Sbjct: 2672 GR 2673
Score = 60.5 bits (145), Expect = 5e-09
Identities = 76/380 (20%), Positives = 174/380 (45%), Gaps = 57/380 (15%)
Query: 210 QKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKK 269
Q+ + ++++L +R + A ++ + ++ + +E S + +Q + +R+K
Sbjct: 1445 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE---SQRKRQAEVELASRVKA 1501
Query: 270 AQRIRELQQQAAKAWEELKRSDQKVQMTLE-------RERRLLLRQSQEQWQEKEQRKTL 322
+Q+A +A EEL+ ++ + L R+ ++ L +Q + + Q K
Sbjct: 1502 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1561
Query: 323 QSPEQRG-LRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLRE 381
E+ L R Q ++V + R + ++ + +Q + E+AR +AE RE
Sbjct: 1562 SFAEKTAQLERSLQEEHVAVAQLR---EEAERRAQQQAEAERAREEAE----------RE 1608
Query: 382 QEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQA 441
E+ L+ +L+L+ + E +++ L E +K+ ++ +AR+ +
Sbjct: 1609 LERW--QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA------EREARR-----RG 1655
Query: 442 KAEE-LLRQLSL-EQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQR 499
KAEE +RQ L EQ ++ +++ +G ++R E++L + R + E+QR
Sbjct: 1656 KAEEQAVRQRELAEQELEKQRQLAEGTAQQR--------LAAEQELIRLRAETEQGEQQR 1707
Query: 500 KMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHIL--KLKAEKEEKCH 557
+L +E++ + + T+ + + EL +R + +L K +AE+E +
Sbjct: 1708 --------QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1759
Query: 558 IEGIKEAIKKKEQRVQHISQ 577
E K+ ++ + R + +++
Sbjct: 1760 SEKSKQRLEAEAGRFRELAE 1779
Score = 52.0 bits (123), Expect = 2e-06
Identities = 60/286 (20%), Positives = 128/286 (44%), Gaps = 12/286 (4%)
Query: 298 LERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPR 357
+E E RL +Q E+ + + + +++ +Q K E++ +Q +E R
Sbjct: 1322 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1381
Query: 358 QEKLEKARAQAEHRKQCQVRRLRE--QEKMLRNLREQHSLQLQR-RLVEACR--KRHLHA 412
+E+ Q + Q ++++LR+ + ++ R+ + + R R+ E R + L A
Sbjct: 1382 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1441
Query: 413 VEGQKKVQDTNLSSL--INYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKER 470
E Q+ + L +L +A Q +AE L RQ+ E +R E+ R +
Sbjct: 1442 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1501
Query: 471 QRELREKAQKEEEQLQQARWRAGESE---EQRKMRKRILVELADEKI-RQARSHVHKTTR 526
+ E + Q+ + L++ R +A E+E Q ++ + V++A E R A + +
Sbjct: 1502 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1561
Query: 527 DKVQHLRELNH-LREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQR 571
+ +L L+E++ + +L+ E E + + E +++ +R
Sbjct: 1562 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1607
Score = 49.3 bits (116), Expect = 1e-05
Identities = 96/469 (20%), Positives = 186/469 (39%), Gaps = 64/469 (13%)
Query: 202 RHSACVCAQKRDSSDQVESLASRDSQPLASSKEMR-----SPHTQVLKSKLEEVVVS-SQ 255
R A A+++ + +VE L ++ A ++++ SP L+S+LE + Q
Sbjct: 995 RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ 1054
Query: 256 DQQIVALVLTRLKKAQR-IRELQ--QQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQ 312
+ + A+ L +LK IR Q ++ +A EE + Q V TL + +
Sbjct: 1055 VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1114
Query: 313 WQEKEQRKTLQS--PEQRGLRRDSQRKNVPPGE-----SRWKEQPED----------QES 355
Q + Q+ T + E RG + +R GE RW+E+ Q
Sbjct: 1115 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1174
Query: 356 PRQEKLEKARAQAEHRKQC--------QVRRLREQEKMLRNLREQHSLQLQRRLVEACRK 407
RQ +LE+ Q + ++ Q R R+++ L + +++ Q R +A +
Sbjct: 1175 VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE 1234
Query: 408 ---RHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQ 464
RH VE ++ ++++ +Y+ + V Q L S + ++
Sbjct: 1235 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ---------LEPVASPAKKPKVQS 1285
Query: 465 GLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKT 524
G Q + + E +++ SE R+M + +E++ + + +
Sbjct: 1286 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE-------EERLAEQQRAEERE 1338
Query: 525 TRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQ 584
+V+ E + H K +AE+E K + ++E + ++E+ Q K +
Sbjct: 1339 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1398
Query: 585 EFQKLPQASRRE-----------ERAPPNSSLDQMVLEAQLRACQQNRG 622
E Q+L Q+S E ER+ + V+ QL A ++ RG
Sbjct: 1399 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1447
Score = 48.5 bits (114), Expect = 2e-05
Identities = 96/440 (21%), Positives = 183/440 (41%), Gaps = 80/440 (18%)
Query: 238 PHTQVLKSKLEEVVVSSQDQQIVALVLT-RLKKAQRIRE-LQQQAAKAWEELKRSDQKVQ 295
P + K+ L+++ ++ QQ L L+ AQ + E LQQ+ + E++R ++V
Sbjct: 1101 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1160
Query: 296 MTLERERRLL----LRQSQEQWQEKEQRKTLQSPEQRGL------RRDSQRKNVPPGESR 345
LER + +L +RQ + + ++ R +S + G RR Q + +P +S+
Sbjct: 1161 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1220
Query: 346 WKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQL-----QRR 400
+ QE E++E+ E ++CQ K N + + LQL Q
Sbjct: 1221 AVREQLRQEQALLEEIER---HGEKVEECQ-----RFAKQYINAIKDYELQLVTYKAQLE 1272
Query: 401 LVEACRKRHLHAVEGQKKVQD-----TNLSSLINYQARKVLMDCQA----KAEELLRQLS 451
V + K+ + +Q+ T+ S L ++ + + + EE L +
Sbjct: 1273 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1332
Query: 452 LEQSFQRSQEIHQGLRKERQ-------------RELREKAQKE----------------- 481
+ +R E+ L K+RQ RE +E Q+
Sbjct: 1333 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1392
Query: 482 ----EEQLQQARWRAGESEEQRKMRKRILVELA----DEKIRQARSHVHKTTRDKVQHLR 533
+E+LQQ R ++ E+E Q K R+ E + +E+IR R + T R +
Sbjct: 1393 KRSIQEELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1451
Query: 534 ELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQAS 593
EL LR + K + +E+ E ++ ++ + QR + Q + + +A+
Sbjct: 1452 ELQALRARAEEAEAQKRQAQEEA--ERLRRQVQDESQRKR---QAEVELASRVKAEAEAA 1506
Query: 594 RREERAPPNSSLDQMVLEAQ 613
R ++RA +L+++ L+A+
Sbjct: 1507 REKQRA--LQALEELRLQAE 1524
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 73.9 bits (180), Expect = 4e-13
Identities = 94/432 (21%), Positives = 193/432 (44%), Gaps = 65/432 (15%)
Query: 214 SSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLK----K 269
S +Q E A+R Q A + R + ++ L +++ ++ + RLK +
Sbjct: 1947 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2006
Query: 270 AQRIRE-LQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQR 328
A+R+RE +Q++A+ + + + QK E+ ++Q +++ Q+ Q++ + R
Sbjct: 2007 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2066
Query: 329 GLRRDSQRKNVPPGESRWKEQPEDQESPRQ----EKLEK-ARAQAEHRKQCQ-----VRR 378
G ++R E+R + + E +S RQ E+L++ A QA+ R Q Q +R+
Sbjct: 2067 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2126
Query: 379 LREQEKMLRNLREQHSLQLQRRLVEACRKRH------------------------LHAVE 414
EQE R EQ +L+ Q++ +A ++H L +
Sbjct: 2127 EAEQEAARRAQAEQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2185
Query: 415 GQKKVQDTNLSSLI---------NYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQG 465
QK + D L L Q + L + + EEL + + ++ R+ +
Sbjct: 2186 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD- 2244
Query: 466 LRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTT 525
+ QR L+E+A+K ++ ++A + ++E ++R +LA+E + Q R+ K
Sbjct: 2245 -KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR-----QLAEEDLAQQRALAEKML 2298
Query: 526 RDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQE 585
++K+Q ++E L+ + + + K +E+ + + KEQ Q +++ Q
Sbjct: 2299 KEKMQAVQEATRLKAEAELLQQQKELAQEQA-----RRLQEDKEQMAQQLAE----ETQG 2349
Query: 586 FQKLPQASRREE 597
FQ+ +A R+ +
Sbjct: 2350 FQRTLEAERQRQ 2361
Score = 72.4 bits (176), Expect = 1e-12
Identities = 85/327 (25%), Positives = 148/327 (45%), Gaps = 40/327 (12%)
Query: 254 SQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQW 313
S ++ VA+ R ++A+R + Q +A +A EE +R ++ Q+ RL L Q++E
Sbjct: 1581 SLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL-QAEEVA 1638
Query: 314 QEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQ 373
Q+K + ++ R+++R+ ++ + + +QE +Q +L + AQ +
Sbjct: 1639 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1698
Query: 374 CQVRRLR---EQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINY 430
++ RLR EQ + R L E+ +LQR A +KR E K +
Sbjct: 1699 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE--------- 1749
Query: 431 QARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARW 490
+VL+ +A+AEE R S E+S QR + R REL E+A AR
Sbjct: 1750 --MEVLLASKARAEEESRSTS-EKSKQRLE-----AEAGRFRELAEEA---------ARL 1792
Query: 491 RAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKA 550
RA E +R+ +LA+E + R+ + +K+ + E L+ + LK K
Sbjct: 1793 RALAEEAKRQR------QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1846
Query: 551 EKEEKCHIEGIKEAIKKK---EQRVQH 574
+ E+ EA +++ EQ QH
Sbjct: 1847 AENERLRRLAEDEAFQRRRLEEQAAQH 1873
Score = 72.4 bits (176), Expect = 1e-12
Identities = 94/422 (22%), Positives = 181/422 (42%), Gaps = 36/422 (8%)
Query: 199 KFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQ- 257
+ K + +K ++++ LA ++ +E + H ++ +L ++ +S +
Sbjct: 1833 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1892
Query: 258 -QIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEK 316
+ LV L++ +++ E + A KA E K + K ++ LE R +R + E
Sbjct: 1893 ERQKGLVEDTLRQRRQVEE-EILALKASFE-KAAAGKAELELELGR---IRSNAEDTLRS 1947
Query: 317 EQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQV 376
+++ L++ QR L + +R+ E K ++E+ RQ K + K +
Sbjct: 1948 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2007
Query: 377 RRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVL 436
RRLRE+ + + Q + + ++ ++A K H AV+ +++ L Q + VL
Sbjct: 2008 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ-----QEQSVL 2062
Query: 437 MDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESE 496
+ +A E R+ + E R Q + + RQ E E+ ++ E+ QAR +A +
Sbjct: 2063 DQLRGEA-EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2121
Query: 497 EQRKMRKRILVE----------------LADEKIRQARSHVHKTTRDKVQHLRELNHLR- 539
E K+RK E AD ++ + + +T R K Q +EL LR
Sbjct: 2122 E--KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2179
Query: 540 --EKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREE 597
E+ H L E+ ++ E EA +++ Q + + + +E KL E
Sbjct: 2180 QLEETDHQKNLLDEELQRLKAEA-TEAARQRSQVEEELFSVR-VQMEELSKLKARIEAEN 2237
Query: 598 RA 599
RA
Sbjct: 2238 RA 2239
Score = 70.5 bits (171), Expect = 4e-12
Identities = 106/495 (21%), Positives = 204/495 (41%), Gaps = 65/495 (13%)
Query: 178 RHLGRWSPSSVPSERSSVPSQKFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRS 237
R L RW + + R + +++ + + A+ ++ E A R + + R
Sbjct: 1615 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1674
Query: 238 PHTQVLKSKLEEVVVSSQDQQIVALVLTRLKK------------AQRIRELQQQAAKAWE 285
Q L+ + + ++Q + L RL+ + + LQ++AA A +
Sbjct: 1675 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1734
Query: 286 ELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQ---------RGLRRDSQR 336
KR + + ++ R +L S+ + E+E R T + +Q R L ++ R
Sbjct: 1735 --KRQELEAELAKVRAEMEVLLASKAR-AEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1791
Query: 337 KNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQC-QVRRLREQEKMLRNLREQHSL 395
E++ + Q ++++ RQ + E R AE + RL+ + ++ +E +
Sbjct: 1792 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1850
Query: 396 QLQRRLV--EACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQ---- 449
+L RRL EA ++R L Q K + + + L + E+ LRQ
Sbjct: 1851 RL-RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1909
Query: 450 ----LSLEQSFQRSQ------EIHQG-LRKERQRELREKAQKEEEQLQQARWRAGESEEQ 498
L+L+ SF+++ E+ G +R + LR K Q E E +Q + A E +
Sbjct: 1910 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1969
Query: 499 RKMRKRILVELA--DEKIRQARSHVHKTTR--DKVQHLRELNHLREKN--------HHIL 546
R+ +R+ LA +E RQ ++ + + R KV+ R L E+
Sbjct: 1970 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2029
Query: 547 KLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREERAPPNSSLD 606
+ + + EEK H A+++KEQ +Q Q + + + +A+RR +
Sbjct: 2030 QKRLQAEEKAH----AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA-----EEAE 2080
Query: 607 QMVLEAQLRACQQNR 621
+ ++A+ A Q R
Sbjct: 2081 EARVQAEREAAQSRR 2095
Score = 67.8 bits (164), Expect = 3e-11
Identities = 101/422 (23%), Positives = 181/422 (42%), Gaps = 63/422 (14%)
Query: 234 EMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKKAQ-RIRELQQQAAKAWEELKRSDQ 292
+ R+ ++LK K++ V +++ + L+ + + AQ + R LQ+ + ++L Q
Sbjct: 2289 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2348
Query: 293 KVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPED 352
Q TLE ER+ L S E + + R S Q D+QR E E+
Sbjct: 2349 GFQRTLEAERQRQLEMSAEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG--EKLHR 2405
Query: 353 QESPRQEK------LEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACR 406
E QEK LE R Q++H RLRE L RE+ LQ + +L++ +
Sbjct: 2406 TELATQEKVTLVQTLEIQRQQSDH----DAERLREAIAELE--REKEKLQQEAKLLQL-K 2458
Query: 407 KRHLHAVEGQKKVQDTNL---------SSLINYQARKVLMDCQAKAEELLR-------QL 450
+ V+ ++ +Q+T SL+ Q + + +AK E+L + QL
Sbjct: 2459 SEEMQTVQQEQLLQETQALQQSFLSEKDSLL--QRERFIEQEKAKLEQLFQDEVAKAQQL 2516
Query: 451 SLEQSFQRSQEIHQGLR--------KERQRELRE---KAQKEEEQLQQARWRAGESEEQR 499
EQ Q+ Q + R + RQ E E + Q+E +QL+Q R + E +
Sbjct: 2517 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE 2576
Query: 500 KMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIE 559
R R ++L +E+ R A +H + T +V + L + R+ + AE E + +
Sbjct: 2577 NQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA---LDGPAAEAEPEHSFD 2633
Query: 560 GIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREERAPPNSSLDQMVLEAQLRACQQ 619
G++ + Q + + + +E Q+L Q ++++D++ +R Q
Sbjct: 2634 GLRRKVS-----AQRLQEAGILSAEELQRLAQG---------HTTVDELARREDVRHYLQ 2679
Query: 620 NR 621
R
Sbjct: 2680 GR 2681
Score = 60.5 bits (145), Expect = 5e-09
Identities = 76/380 (20%), Positives = 174/380 (45%), Gaps = 57/380 (15%)
Query: 210 QKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKK 269
Q+ + ++++L +R + A ++ + ++ + +E S + +Q + +R+K
Sbjct: 1453 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE---SQRKRQAEVELASRVKA 1509
Query: 270 AQRIRELQQQAAKAWEELKRSDQKVQMTLE-------RERRLLLRQSQEQWQEKEQRKTL 322
+Q+A +A EEL+ ++ + L R+ ++ L +Q + + Q K
Sbjct: 1510 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1569
Query: 323 QSPEQRG-LRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLRE 381
E+ L R Q ++V + R + ++ + +Q + E+AR +AE RE
Sbjct: 1570 SFAEKTAQLERSLQEEHVAVAQLR---EEAERRAQQQAEAERAREEAE----------RE 1616
Query: 382 QEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQA 441
E+ L+ +L+L+ + E +++ L E +K+ ++ +AR+ +
Sbjct: 1617 LERW--QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA------EREARR-----RG 1663
Query: 442 KAEE-LLRQLSL-EQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQR 499
KAEE +RQ L EQ ++ +++ +G ++R E++L + R + E+QR
Sbjct: 1664 KAEEQAVRQRELAEQELEKQRQLAEGTAQQR--------LAAEQELIRLRAETEQGEQQR 1715
Query: 500 KMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHIL--KLKAEKEEKCH 557
+L +E++ + + T+ + + EL +R + +L K +AE+E +
Sbjct: 1716 --------QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1767
Query: 558 IEGIKEAIKKKEQRVQHISQ 577
E K+ ++ + R + +++
Sbjct: 1768 SEKSKQRLEAEAGRFRELAE 1787
Score = 52.0 bits (123), Expect = 2e-06
Identities = 60/286 (20%), Positives = 128/286 (44%), Gaps = 12/286 (4%)
Query: 298 LERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPR 357
+E E RL +Q E+ + + + +++ +Q K E++ +Q +E R
Sbjct: 1330 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1389
Query: 358 QEKLEKARAQAEHRKQCQVRRLRE--QEKMLRNLREQHSLQLQR-RLVEACR--KRHLHA 412
+E+ Q + Q ++++LR+ + ++ R+ + + R R+ E R + L A
Sbjct: 1390 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1449
Query: 413 VEGQKKVQDTNLSSL--INYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKER 470
E Q+ + L +L +A Q +AE L RQ+ E +R E+ R +
Sbjct: 1450 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1509
Query: 471 QRELREKAQKEEEQLQQARWRAGESE---EQRKMRKRILVELADEKI-RQARSHVHKTTR 526
+ E + Q+ + L++ R +A E+E Q ++ + V++A E R A + +
Sbjct: 1510 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1569
Query: 527 DKVQHLRELNH-LREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQR 571
+ +L L+E++ + +L+ E E + + E +++ +R
Sbjct: 1570 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1615
Score = 49.3 bits (116), Expect = 1e-05
Identities = 96/469 (20%), Positives = 186/469 (39%), Gaps = 64/469 (13%)
Query: 202 RHSACVCAQKRDSSDQVESLASRDSQPLASSKEMR-----SPHTQVLKSKLEEVVVS-SQ 255
R A A+++ + +VE L ++ A ++++ SP L+S+LE + Q
Sbjct: 1003 RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ 1062
Query: 256 DQQIVALVLTRLKKAQR-IRELQ--QQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQ 312
+ + A+ L +LK IR Q ++ +A EE + Q V TL + +
Sbjct: 1063 VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1122
Query: 313 WQEKEQRKTLQS--PEQRGLRRDSQRKNVPPGE-----SRWKEQPED----------QES 355
Q + Q+ T + E RG + +R GE RW+E+ Q
Sbjct: 1123 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1182
Query: 356 PRQEKLEKARAQAEHRKQC--------QVRRLREQEKMLRNLREQHSLQLQRRLVEACRK 407
RQ +LE+ Q + ++ Q R R+++ L + +++ Q R +A +
Sbjct: 1183 VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE 1242
Query: 408 ---RHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQ 464
RH VE ++ ++++ +Y+ + V Q L S + ++
Sbjct: 1243 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ---------LEPVASPAKKPKVQS 1293
Query: 465 GLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKT 524
G Q + + E +++ SE R+M + +E++ + + +
Sbjct: 1294 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE-------EERLAEQQRAEERE 1346
Query: 525 TRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQ 584
+V+ E + H K +AE+E K + ++E + ++E+ Q K +
Sbjct: 1347 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1406
Query: 585 EFQKLPQASRRE-----------ERAPPNSSLDQMVLEAQLRACQQNRG 622
E Q+L Q+S E ER+ + V+ QL A ++ RG
Sbjct: 1407 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1455
Score = 48.5 bits (114), Expect = 2e-05
Identities = 96/440 (21%), Positives = 183/440 (41%), Gaps = 80/440 (18%)
Query: 238 PHTQVLKSKLEEVVVSSQDQQIVALVLT-RLKKAQRIRE-LQQQAAKAWEELKRSDQKVQ 295
P + K+ L+++ ++ QQ L L+ AQ + E LQQ+ + E++R ++V
Sbjct: 1109 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1168
Query: 296 MTLERERRLL----LRQSQEQWQEKEQRKTLQSPEQRGL------RRDSQRKNVPPGESR 345
LER + +L +RQ + + ++ R +S + G RR Q + +P +S+
Sbjct: 1169 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1228
Query: 346 WKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQL-----QRR 400
+ QE E++E+ E ++CQ K N + + LQL Q
Sbjct: 1229 AVREQLRQEQALLEEIER---HGEKVEECQ-----RFAKQYINAIKDYELQLVTYKAQLE 1280
Query: 401 LVEACRKRHLHAVEGQKKVQD-----TNLSSLINYQARKVLMDCQA----KAEELLRQLS 451
V + K+ + +Q+ T+ S L ++ + + + EE L +
Sbjct: 1281 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1340
Query: 452 LEQSFQRSQEIHQGLRKERQ-------------RELREKAQKE----------------- 481
+ +R E+ L K+RQ RE +E Q+
Sbjct: 1341 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1400
Query: 482 ----EEQLQQARWRAGESEEQRKMRKRILVELA----DEKIRQARSHVHKTTRDKVQHLR 533
+E+LQQ R ++ E+E Q K R+ E + +E+IR R + T R +
Sbjct: 1401 KRSIQEELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1459
Query: 534 ELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQAS 593
EL LR + K + +E+ E ++ ++ + QR + Q + + +A+
Sbjct: 1460 ELQALRARAEEAEAQKRQAQEEA--ERLRRQVQDESQRKR---QAEVELASRVKAEAEAA 1514
Query: 594 RREERAPPNSSLDQMVLEAQ 613
R ++RA +L+++ L+A+
Sbjct: 1515 REKQRA--LQALEELRLQAE 1532
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 73.9 bits (180), Expect = 4e-13
Identities = 94/432 (21%), Positives = 193/432 (44%), Gaps = 65/432 (15%)
Query: 214 SSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLK----K 269
S +Q E A+R Q A + R + ++ L +++ ++ + RLK +
Sbjct: 1988 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2047
Query: 270 AQRIRE-LQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQR 328
A+R+RE +Q++A+ + + + QK E+ ++Q +++ Q+ Q++ + R
Sbjct: 2048 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2107
Query: 329 GLRRDSQRKNVPPGESRWKEQPEDQESPRQ----EKLEK-ARAQAEHRKQCQ-----VRR 378
G ++R E+R + + E +S RQ E+L++ A QA+ R Q Q +R+
Sbjct: 2108 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2167
Query: 379 LREQEKMLRNLREQHSLQLQRRLVEACRKRH------------------------LHAVE 414
EQE R EQ +L+ Q++ +A ++H L +
Sbjct: 2168 EAEQEAARRAQAEQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2226
Query: 415 GQKKVQDTNLSSLI---------NYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQG 465
QK + D L L Q + L + + EEL + + ++ R+ +
Sbjct: 2227 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD- 2285
Query: 466 LRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTT 525
+ QR L+E+A+K ++ ++A + ++E ++R +LA+E + Q R+ K
Sbjct: 2286 -KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR-----QLAEEDLAQQRALAEKML 2339
Query: 526 RDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQE 585
++K+Q ++E L+ + + + K +E+ + + KEQ Q +++ Q
Sbjct: 2340 KEKMQAVQEATRLKAEAELLQQQKELAQEQA-----RRLQEDKEQMAQQLAE----ETQG 2390
Query: 586 FQKLPQASRREE 597
FQ+ +A R+ +
Sbjct: 2391 FQRTLEAERQRQ 2402
Score = 72.4 bits (176), Expect = 1e-12
Identities = 85/327 (25%), Positives = 148/327 (45%), Gaps = 40/327 (12%)
Query: 254 SQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQW 313
S ++ VA+ R ++A+R + Q +A +A EE +R ++ Q+ RL L Q++E
Sbjct: 1622 SLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL-QAEEVA 1679
Query: 314 QEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQ 373
Q+K + ++ R+++R+ ++ + + +QE +Q +L + AQ +
Sbjct: 1680 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1739
Query: 374 CQVRRLR---EQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINY 430
++ RLR EQ + R L E+ +LQR A +KR E K +
Sbjct: 1740 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE--------- 1790
Query: 431 QARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARW 490
+VL+ +A+AEE R S E+S QR + R REL E+A AR
Sbjct: 1791 --MEVLLASKARAEEESRSTS-EKSKQRLE-----AEAGRFRELAEEA---------ARL 1833
Query: 491 RAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKA 550
RA E +R+ +LA+E + R+ + +K+ + E L+ + LK K
Sbjct: 1834 RALAEEAKRQR------QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1887
Query: 551 EKEEKCHIEGIKEAIKKK---EQRVQH 574
+ E+ EA +++ EQ QH
Sbjct: 1888 AENERLRRLAEDEAFQRRRLEEQAAQH 1914
Score = 72.4 bits (176), Expect = 1e-12
Identities = 94/422 (22%), Positives = 181/422 (42%), Gaps = 36/422 (8%)
Query: 199 KFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQ- 257
+ K + +K ++++ LA ++ +E + H ++ +L ++ +S +
Sbjct: 1874 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1933
Query: 258 -QIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEK 316
+ LV L++ +++ E + A KA E K + K ++ LE R +R + E
Sbjct: 1934 ERQKGLVEDTLRQRRQVEE-EILALKASFE-KAAAGKAELELELGR---IRSNAEDTLRS 1988
Query: 317 EQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQV 376
+++ L++ QR L + +R+ E K ++E+ RQ K + K +
Sbjct: 1989 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2048
Query: 377 RRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVL 436
RRLRE+ + + Q + + ++ ++A K H AV+ +++ L Q + VL
Sbjct: 2049 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ-----QEQSVL 2103
Query: 437 MDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESE 496
+ +A E R+ + E R Q + + RQ E E+ ++ E+ QAR +A +
Sbjct: 2104 DQLRGEA-EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2162
Query: 497 EQRKMRKRILVE----------------LADEKIRQARSHVHKTTRDKVQHLRELNHLR- 539
E K+RK E AD ++ + + +T R K Q +EL LR
Sbjct: 2163 E--KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2220
Query: 540 --EKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREE 597
E+ H L E+ ++ E EA +++ Q + + + +E KL E
Sbjct: 2221 QLEETDHQKNLLDEELQRLKAEA-TEAARQRSQVEEELFSVR-VQMEELSKLKARIEAEN 2278
Query: 598 RA 599
RA
Sbjct: 2279 RA 2280
Score = 70.5 bits (171), Expect = 4e-12
Identities = 106/495 (21%), Positives = 204/495 (41%), Gaps = 65/495 (13%)
Query: 178 RHLGRWSPSSVPSERSSVPSQKFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRS 237
R L RW + + R + +++ + + A+ ++ E A R + + R
Sbjct: 1656 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1715
Query: 238 PHTQVLKSKLEEVVVSSQDQQIVALVLTRLKK------------AQRIRELQQQAAKAWE 285
Q L+ + + ++Q + L RL+ + + LQ++AA A +
Sbjct: 1716 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1775
Query: 286 ELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQ---------RGLRRDSQR 336
KR + + ++ R +L S+ + E+E R T + +Q R L ++ R
Sbjct: 1776 --KRQELEAELAKVRAEMEVLLASKAR-AEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1832
Query: 337 KNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQC-QVRRLREQEKMLRNLREQHSL 395
E++ + Q ++++ RQ + E R AE + RL+ + ++ +E +
Sbjct: 1833 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1891
Query: 396 QLQRRLV--EACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQ---- 449
+L RRL EA ++R L Q K + + + L + E+ LRQ
Sbjct: 1892 RL-RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1950
Query: 450 ----LSLEQSFQRSQ------EIHQG-LRKERQRELREKAQKEEEQLQQARWRAGESEEQ 498
L+L+ SF+++ E+ G +R + LR K Q E E +Q + A E +
Sbjct: 1951 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 2010
Query: 499 RKMRKRILVELA--DEKIRQARSHVHKTTR--DKVQHLRELNHLREKN--------HHIL 546
R+ +R+ LA +E RQ ++ + + R KV+ R L E+
Sbjct: 2011 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2070
Query: 547 KLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREERAPPNSSLD 606
+ + + EEK H A+++KEQ +Q Q + + + +A+RR +
Sbjct: 2071 QKRLQAEEKAH----AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA-----EEAE 2121
Query: 607 QMVLEAQLRACQQNR 621
+ ++A+ A Q R
Sbjct: 2122 EARVQAEREAAQSRR 2136
Score = 67.8 bits (164), Expect = 3e-11
Identities = 101/422 (23%), Positives = 181/422 (42%), Gaps = 63/422 (14%)
Query: 234 EMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKKAQ-RIRELQQQAAKAWEELKRSDQ 292
+ R+ ++LK K++ V +++ + L+ + + AQ + R LQ+ + ++L Q
Sbjct: 2330 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2389
Query: 293 KVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPED 352
Q TLE ER+ L S E + + R S Q D+QR E E+
Sbjct: 2390 GFQRTLEAERQRQLEMSAEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG--EKLHR 2446
Query: 353 QESPRQEK------LEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACR 406
E QEK LE R Q++H RLRE L RE+ LQ + +L++ +
Sbjct: 2447 TELATQEKVTLVQTLEIQRQQSDH----DAERLREAIAELE--REKEKLQQEAKLLQL-K 2499
Query: 407 KRHLHAVEGQKKVQDTNL---------SSLINYQARKVLMDCQAKAEELLR-------QL 450
+ V+ ++ +Q+T SL+ Q + + +AK E+L + QL
Sbjct: 2500 SEEMQTVQQEQLLQETQALQQSFLSEKDSLL--QRERFIEQEKAKLEQLFQDEVAKAQQL 2557
Query: 451 SLEQSFQRSQEIHQGLR--------KERQRELRE---KAQKEEEQLQQARWRAGESEEQR 499
EQ Q+ Q + R + RQ E E + Q+E +QL+Q R + E +
Sbjct: 2558 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE 2617
Query: 500 KMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIE 559
R R ++L +E+ R A +H + T +V + L + R+ + AE E + +
Sbjct: 2618 NQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA---LDGPAAEAEPEHSFD 2674
Query: 560 GIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREERAPPNSSLDQMVLEAQLRACQQ 619
G++ + Q + + + +E Q+L Q ++++D++ +R Q
Sbjct: 2675 GLRRKVS-----AQRLQEAGILSAEELQRLAQG---------HTTVDELARREDVRHYLQ 2720
Query: 620 NR 621
R
Sbjct: 2721 GR 2722
Score = 60.5 bits (145), Expect = 5e-09
Identities = 76/380 (20%), Positives = 174/380 (45%), Gaps = 57/380 (15%)
Query: 210 QKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKK 269
Q+ + ++++L +R + A ++ + ++ + +E S + +Q + +R+K
Sbjct: 1494 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE---SQRKRQAEVELASRVKA 1550
Query: 270 AQRIRELQQQAAKAWEELKRSDQKVQMTLE-------RERRLLLRQSQEQWQEKEQRKTL 322
+Q+A +A EEL+ ++ + L R+ ++ L +Q + + Q K
Sbjct: 1551 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1610
Query: 323 QSPEQRG-LRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLRE 381
E+ L R Q ++V + R + ++ + +Q + E+AR +AE RE
Sbjct: 1611 SFAEKTAQLERSLQEEHVAVAQLR---EEAERRAQQQAEAERAREEAE----------RE 1657
Query: 382 QEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQA 441
E+ L+ +L+L+ + E +++ L E +K+ ++ +AR+ +
Sbjct: 1658 LERW--QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA------EREARR-----RG 1704
Query: 442 KAEE-LLRQLSL-EQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQR 499
KAEE +RQ L EQ ++ +++ +G ++R E++L + R + E+QR
Sbjct: 1705 KAEEQAVRQRELAEQELEKQRQLAEGTAQQR--------LAAEQELIRLRAETEQGEQQR 1756
Query: 500 KMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHIL--KLKAEKEEKCH 557
+L +E++ + + T+ + + EL +R + +L K +AE+E +
Sbjct: 1757 --------QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1808
Query: 558 IEGIKEAIKKKEQRVQHISQ 577
E K+ ++ + R + +++
Sbjct: 1809 SEKSKQRLEAEAGRFRELAE 1828
Score = 52.0 bits (123), Expect = 2e-06
Identities = 60/286 (20%), Positives = 128/286 (44%), Gaps = 12/286 (4%)
Query: 298 LERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPR 357
+E E RL +Q E+ + + + +++ +Q K E++ +Q +E R
Sbjct: 1371 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1430
Query: 358 QEKLEKARAQAEHRKQCQVRRLRE--QEKMLRNLREQHSLQLQR-RLVEACR--KRHLHA 412
+E+ Q + Q ++++LR+ + ++ R+ + + R R+ E R + L A
Sbjct: 1431 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1490
Query: 413 VEGQKKVQDTNLSSL--INYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKER 470
E Q+ + L +L +A Q +AE L RQ+ E +R E+ R +
Sbjct: 1491 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1550
Query: 471 QRELREKAQKEEEQLQQARWRAGESE---EQRKMRKRILVELADEKI-RQARSHVHKTTR 526
+ E + Q+ + L++ R +A E+E Q ++ + V++A E R A + +
Sbjct: 1551 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1610
Query: 527 DKVQHLRELNH-LREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQR 571
+ +L L+E++ + +L+ E E + + E +++ +R
Sbjct: 1611 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1656
Score = 49.3 bits (116), Expect = 1e-05
Identities = 96/469 (20%), Positives = 186/469 (39%), Gaps = 64/469 (13%)
Query: 202 RHSACVCAQKRDSSDQVESLASRDSQPLASSKEMR-----SPHTQVLKSKLEEVVVS-SQ 255
R A A+++ + +VE L ++ A ++++ SP L+S+LE + Q
Sbjct: 1044 RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ 1103
Query: 256 DQQIVALVLTRLKKAQR-IRELQ--QQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQ 312
+ + A+ L +LK IR Q ++ +A EE + Q V TL + +
Sbjct: 1104 VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1163
Query: 313 WQEKEQRKTLQS--PEQRGLRRDSQRKNVPPGE-----SRWKEQPED----------QES 355
Q + Q+ T + E RG + +R GE RW+E+ Q
Sbjct: 1164 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1223
Query: 356 PRQEKLEKARAQAEHRKQC--------QVRRLREQEKMLRNLREQHSLQLQRRLVEACRK 407
RQ +LE+ Q + ++ Q R R+++ L + +++ Q R +A +
Sbjct: 1224 VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE 1283
Query: 408 ---RHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQ 464
RH VE ++ ++++ +Y+ + V Q L S + ++
Sbjct: 1284 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ---------LEPVASPAKKPKVQS 1334
Query: 465 GLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKT 524
G Q + + E +++ SE R+M + +E++ + + +
Sbjct: 1335 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE-------EERLAEQQRAEERE 1387
Query: 525 TRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQ 584
+V+ E + H K +AE+E K + ++E + ++E+ Q K +
Sbjct: 1388 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1447
Query: 585 EFQKLPQASRRE-----------ERAPPNSSLDQMVLEAQLRACQQNRG 622
E Q+L Q+S E ER+ + V+ QL A ++ RG
Sbjct: 1448 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1496
Score = 48.5 bits (114), Expect = 2e-05
Identities = 96/440 (21%), Positives = 183/440 (41%), Gaps = 80/440 (18%)
Query: 238 PHTQVLKSKLEEVVVSSQDQQIVALVLT-RLKKAQRIRE-LQQQAAKAWEELKRSDQKVQ 295
P + K+ L+++ ++ QQ L L+ AQ + E LQQ+ + E++R ++V
Sbjct: 1150 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1209
Query: 296 MTLERERRLL----LRQSQEQWQEKEQRKTLQSPEQRGL------RRDSQRKNVPPGESR 345
LER + +L +RQ + + ++ R +S + G RR Q + +P +S+
Sbjct: 1210 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1269
Query: 346 WKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQL-----QRR 400
+ QE E++E+ E ++CQ K N + + LQL Q
Sbjct: 1270 AVREQLRQEQALLEEIER---HGEKVEECQ-----RFAKQYINAIKDYELQLVTYKAQLE 1321
Query: 401 LVEACRKRHLHAVEGQKKVQD-----TNLSSLINYQARKVLMDCQA----KAEELLRQLS 451
V + K+ + +Q+ T+ S L ++ + + + EE L +
Sbjct: 1322 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1381
Query: 452 LEQSFQRSQEIHQGLRKERQ-------------RELREKAQKE----------------- 481
+ +R E+ L K+RQ RE +E Q+
Sbjct: 1382 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1441
Query: 482 ----EEQLQQARWRAGESEEQRKMRKRILVELA----DEKIRQARSHVHKTTRDKVQHLR 533
+E+LQQ R ++ E+E Q K R+ E + +E+IR R + T R +
Sbjct: 1442 KRSIQEELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1500
Query: 534 ELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQAS 593
EL LR + K + +E+ E ++ ++ + QR + Q + + +A+
Sbjct: 1501 ELQALRARAEEAEAQKRQAQEEA--ERLRRQVQDESQRKR---QAEVELASRVKAEAEAA 1555
Query: 594 RREERAPPNSSLDQMVLEAQ 613
R ++RA +L+++ L+A+
Sbjct: 1556 REKQRA--LQALEELRLQAE 1573
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 72.8 bits (177), Expect = 9e-13
Identities = 85/391 (21%), Positives = 182/391 (46%), Gaps = 49/391 (12%)
Query: 257 QQIVALVLTRLKKAQR-IRELQQQAAKAW----------EELKRSDQKVQMTL---ERER 302
+Q ++ V T+ KKA R I EL ++ EELK + K+Q L E E+
Sbjct: 166 EQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEK 225
Query: 303 RLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQE------SP 356
+ +E ++ E+ K L +Q D K + ++ + Q E+ E
Sbjct: 226 SEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQ 285
Query: 357 RQEKL---EKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAV 413
++EK+ E+ + E + Q Q ++REQE+ +R Q + ++ E R++
Sbjct: 286 QEEKMWRQEEKIQEREEKIQEQEEKIREQEE---KMRRQEEMMWEKE--EKMRRQEEMMW 340
Query: 414 EGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRE 473
E ++K+++ L ++ Q + + + + EE +R EQ ++ QE ++E+ RE
Sbjct: 341 EKEEKIRE--LEEKMHEQEKIREQEEKRQEEEKIR----EQEKRQEQEAKMWRQEEKIRE 394
Query: 474 LREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVH---KTTRDKVQ 530
EK +++EE +Q+ + GE EE+ ++ + E +EK+R+ + K R++ +
Sbjct: 395 QEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQE-QEEKMRRQEEKIREQEKKIREQEE 453
Query: 531 HLRELNHLREKNHHILKLKAEK--EEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQK 588
+RE + ++ + + K E++ ++ +E ++++E++++ QE +
Sbjct: 454 KIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIRE---------QEKKI 504
Query: 589 LPQASRREERAPPNSSLDQMVLEAQLRACQQ 619
Q + E+ ++ + E + + C+Q
Sbjct: 505 REQEEKIREQEEMMQEQEEKMWEQEEKMCEQ 535
Score = 69.7 bits (169), Expect = 8e-12
Identities = 96/420 (22%), Positives = 196/420 (46%), Gaps = 47/420 (11%)
Query: 205 ACVCAQKRDSSDQVESLAS-RDSQPLA------SSKEMRSPHTQVLKSKLEEVVVSSQDQ 257
+ V QK+ + +E L RD+ L + +E++ + + L+ KL+ V +
Sbjct: 170 SAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAK-LQEKLQLVESEKSEI 228
Query: 258 QIVALVLTR-LKKAQRI---RELQQQAAKAWEELKRSDQKVQMTLERER---RLLLRQSQ 310
Q+ L R L++A+ + ++LQ +A +EL+ K+Q +E RL +Q +
Sbjct: 229 QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEE 288
Query: 311 EQWQEKE--QRKTLQSPEQRGLRRDSQRKNVPPGESRWK--EQPEDQESPRQEKLEKARA 366
+ W+++E Q + + EQ R+ + K E W+ E+ QE EK EK R
Sbjct: 289 KMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRE 348
Query: 367 QAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAV-EGQKKVQDTNLS 425
E K + ++REQE+ R E+ Q +R+ EA R + E ++K+++
Sbjct: 349 LEE--KMHEQEKIREQEEK-RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE-- 403
Query: 426 SLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELR-----EKAQK 480
++ Q K+ + E+ E+ +R +E K R++E + EK ++
Sbjct: 404 EMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEE------KIREQEKKIREQEEKIRE 457
Query: 481 EEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHV---HKTTRDKVQHLRELNH 537
+EE +Q+ + GE +E + + ++ +EK+R+ + K R++ + +RE
Sbjct: 458 QEEMMQEQEEKMGE-QEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 516
Query: 538 LREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREE 597
+ ++ K+ ++E+ C E E ++++E++++ Q + QE + Q + +E
Sbjct: 517 MMQEQEE--KMWEQEEKMCEQE---EKMQEQEEKMRR--QEEKMREQEVRLRQQEEKMQE 569
Score = 67.8 bits (164), Expect = 3e-11
Identities = 72/321 (22%), Positives = 156/321 (48%), Gaps = 32/321 (9%)
Query: 233 KEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKKAQ-RIRELQQQAAKAWEELKRSD 291
KE++S ++ E + + +QQ + + +K Q R ++Q+Q K E+ ++
Sbjct: 260 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMR 319
Query: 292 QKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSP--EQRGLRRDSQRKNVPPGESRWKEQ 349
++ +M E+E ++ RQ + W+++E+ + L+ EQ +R + + K + R +E+
Sbjct: 320 RQEEMMWEKEEKMR-RQEEMMWEKEEKIRELEEKMHEQEKIR-EQEEKRQEEEKIREQEK 377
Query: 350 PEDQESP---RQEKL----EKARAQAEHRKQCQVRRLREQEKMLRNLRE-QHSLQLQRRL 401
++QE+ ++EK+ EK R Q E ++ + + ++EKM E Q + RR
Sbjct: 378 RQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQ 437
Query: 402 VEACRKRHLHAVEGQKKVQDTNLSSLINYQARKV------LMDCQAKAEELLRQLSLEQS 455
E R++ E ++K+++ ++ Q K+ + + +AK +E ++ ++
Sbjct: 438 EEKIREQEKKIREQEEKIREQ--EEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEE 495
Query: 456 FQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEE-----QRKMRKRILVELA 510
R QE ++E+ RE E Q++EE++ + + E EE + KMR++
Sbjct: 496 KIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ------ 549
Query: 511 DEKIRQARSHVHKTTRDKVQH 531
+EK+R+ + + +H
Sbjct: 550 EEKMREQEVRLRQQEEKMQEH 570
Score = 60.1 bits (144), Expect = 6e-09
Identities = 65/303 (21%), Positives = 145/303 (47%), Gaps = 45/303 (14%)
Query: 198 QKFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKS--KLEEVVVSSQ 255
+K + + Q+ +Q E + ++ ++MR + + K+ E+
Sbjct: 295 EKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMH 354
Query: 256 DQQIVALVLTRLKKAQRIREL---QQQAAKAW---EELKRSDQKV----QMTLERERRLL 305
+Q+ + + ++ ++IRE Q+Q AK W E+++ ++K+ +M E+E + +
Sbjct: 355 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEK-M 413
Query: 306 LRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPE---DQESPRQEKLE 362
Q ++ W+++E+ +Q E++ +RR Q + + E + +EQ E +QE QE+ E
Sbjct: 414 GEQEEKMWEQEEE---MQEQEEK-MRR--QEEKIREQEKKIREQEEKIREQEEMMQEQEE 467
Query: 363 KARAQAEHRKQC-QVRRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQD 421
K Q K C Q +++EQE+ +R R++ ++ Q + + E ++K+++
Sbjct: 468 KMGEQ--EGKMCEQEAKMQEQEEKMR--RQEEKIREQEKKIR----------EQEEKIRE 513
Query: 422 TNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKE 481
++ Q K+ + E+ + E+ +R +E K R++E+R + Q+E
Sbjct: 514 Q--EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE------KMREQEVRLRQQEE 565
Query: 482 EEQ 484
+ Q
Sbjct: 566 KMQ 568
Score = 52.0 bits (123), Expect = 2e-06
Identities = 80/400 (20%), Positives = 173/400 (43%), Gaps = 45/400 (11%)
Query: 248 EEVVVSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLR 307
+E S Q Q+ + L + Q IR L Q + L S V+ LE E R L+
Sbjct: 97 DEQKASHQHQEALRRELEA--QVQTIRILTCQKTELQMALYYSQHAVKQ-LEGEARDLIS 153
Query: 308 QSQEQWQ---EKEQR----KTLQSPEQRGLRRDSQRKNVPPGE----SRWKEQPEDQESP 356
+ + W+ E EQ T + R + ++ ++ E + E+ +++ +
Sbjct: 154 RLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAK 213
Query: 357 RQEKLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEG- 415
QEKL+ ++ + Q V+ L+ + + + L Q LQ + + + L +V
Sbjct: 214 LQEKLQLVESE-KSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG----KELQSVSAK 268
Query: 416 -QKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQREL 474
Q +V++ L + +N Q + + + K +E ++ ++ R QE ++E E
Sbjct: 269 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEK 328
Query: 475 REKAQKEEEQLQQARWRAGESE----EQRKMRKRILVELADEKIRQARSHVHKTT----- 525
EK +++EE + + + E E EQ K+R++ +EKIR+ +
Sbjct: 329 EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ 388
Query: 526 ----RDKVQHLRELNHLREKNHHILKLKAEK--EEKCHIEGIKEAIKKKEQRVQHISQGK 579
R++ + +RE + ++ + + EK E++ ++ +E ++++E++++
Sbjct: 389 EEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIRE----- 443
Query: 580 DPNFQEFQKLPQASRREERAPPNSSLDQMVLEAQLRACQQ 619
QE + Q + E+ ++ + E + + C+Q
Sbjct: 444 ----QEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQ 479
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 71.2 bits (173), Expect = 3e-12
Identities = 85/461 (18%), Positives = 189/461 (40%), Gaps = 64/461 (13%)
Query: 170 DQWAVPLGRHLGRWSPSSVPSERSSVPSQKFKRHSACVCAQ-----KRDSSDQVESLASR 224
D+W G P +V ++ ++ KR + + SS+
Sbjct: 170 DEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQES 229
Query: 225 DSQPLASSKEMRS------------PHTQVLKSKLEEVVVSSQDQQIVALVLTRL----- 267
DS P KE + P+ + K + + + + +++ +++
Sbjct: 230 DSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHK 289
Query: 268 -------KKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRK 320
KK + +E++++ + E +R ++ + ERER + +E+ +E+E+ +
Sbjct: 290 KLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDR 349
Query: 321 TLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLR 380
++R RD +R R +E+ D+ R EK+R E ++ + R R
Sbjct: 350 DRDRTKERDRDRDRER-----DRDRDRERSSDRNKDRSRSREKSR-DRERERERERERER 403
Query: 381 EQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKV---LM 437
E+E+ RE+ + + R E +KR + ++ +D Y+ RK+ L
Sbjct: 404 EREREREREREREREREREREREKDKKR-----DREEDEEDA-------YERRKLERKLR 451
Query: 438 DCQAKAEELLRQLSL-EQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESE 496
+ +A +E L+ + E+ R E +ER+RE+ ++A++ +E L+ + +
Sbjct: 452 EKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLE-------DYD 504
Query: 497 EQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKC 556
+ R K +++R + RD+ + EL +R++ L + +
Sbjct: 505 DDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQR----LLAEGHPDPDA 560
Query: 557 HIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREE 597
++ +++ +++ Q I Q + +E +K + +REE
Sbjct: 561 ELQRMEQEAERRRQ--PQIKQEPESEEEEEEKQEKEEKREE 599
Score = 59.7 bits (143), Expect = 8e-09
Identities = 72/316 (22%), Positives = 138/316 (43%), Gaps = 25/316 (7%)
Query: 304 LLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEK 363
L+ ++ + +E ++ L S E R D+ +K + KE+ E ++ R+ + E+
Sbjct: 258 LITKEDINAIEMEEDKRDLISREISKFR-DTHKKLEEEKGKKEKERQEIEKERRERERER 316
Query: 364 ARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTN 423
R + ++ + R RE+EK RE+ + + R E R R + + +D
Sbjct: 317 ERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRE----RDRDRDRE 372
Query: 424 LSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEE 483
SS N ++++ E R E+ +R +E + +ER+RE RE+ ++ E
Sbjct: 373 RSSDRNKD--------RSRSREKSRDRERERERERERERERERERERERE-RERERERER 423
Query: 484 QLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNH 543
+ ++ + R E +E+ +R L + K+R+ + + R K +RE RE
Sbjct: 424 EREKDKKRDREEDEEDAYERRKL----ERKLREKEAAYQE--RLKNWEIRERKKTRE--- 474
Query: 544 HILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREERAPPNS 603
+ +AE+EE+ E KEA + KE + DP + L + R E+
Sbjct: 475 --YEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEAD 532
Query: 604 SLDQMVLEAQLRACQQ 619
D+ + +L +Q
Sbjct: 533 ERDRKREKEELEEIRQ 548
Score = 53.5 bits (127), Expect = 6e-07
Identities = 51/252 (20%), Positives = 115/252 (45%), Gaps = 22/252 (8%)
Query: 266 RLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSP 325
R K R RE + + E + +++ + ERER + +E+ +EK++++ +
Sbjct: 377 RNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREED 436
Query: 326 EQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEKM 385
E+ R + + E+ ++E+ ++ E ++K + +AE R++ + R + ++ K
Sbjct: 437 EEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAE-REEERRREMAKEAKR 495
Query: 386 LRNLREQHS-----------LQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARK 434
L+ E + LQ+RL + R++ + A E +K + L + ++
Sbjct: 496 LKEFLEDYDDDRDDPKYYRGSALQKRLRD--REKEMEADERDRKREKEELEEI----RQR 549
Query: 435 VLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGE 494
+L + + L+++ E +R +I Q E + E E+ ++E+E+ ++ E
Sbjct: 550 LLAEGHPDPDAELQRMEQEAERRRQPQIKQ----EPESEEEEEEKQEKEEKREEPMEEEE 605
Query: 495 SEEQRKMRKRIL 506
EQ+ K L
Sbjct: 606 EPEQKPCLKPTL 617
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 70.9 bits (172), Expect = 3e-12
Identities = 119/551 (21%), Positives = 226/551 (41%), Gaps = 71/551 (12%)
Query: 89 ARRPLERSRKHRPRSRRLEDAWGETGTKPRPAWQPQTQLPPQRPQPCPHYPLAQGDSPPP 148
A +PLE S + +D+ E ++P QT PP P + P
Sbjct: 354 ADKPLEESPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTSPPVVA------PGNENGLAVP 407
Query: 149 CPGGAGTPLSGTFRVEKAQ-------GGD-QWAVPLGRHLGRWSPSSV------------ 188
P P+S R++ AQ GGD A + + P+S
Sbjct: 408 VPLRKSRPVSMDARIQVAQEKQVAEQGGDLSPAANRSQKASQSRPNSSALETLGGEKLAN 467
Query: 189 -----PSERSSVPSQKFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRS---PHT 240
P++ + PS KR S C +S D +L S L+ +KEM S
Sbjct: 468 GSLEPPAQAAPGPS---KRDSDCSSLCTSESMDYGTNL----STDLSLNKEMGSLSIKDP 520
Query: 241 QVLKSKLEEVVVSSQDQQIVALVLTRL-----KKAQRIRELQQQAAKAWEELKRSDQKVQ 295
++ K L+ D V++ +++ KK + +R L++Q + L++ + + Q
Sbjct: 521 KLYKKTLKRTRKFVVDGVEVSITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQ 580
Query: 296 MTLERERRLLLRQSQEQW-QEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQE 354
L + L L Q +++ QE +K E L R Q++ V E +E
Sbjct: 581 TQLSNKHELQLEQMHKRFEQEINAKKKFFDTELENLERQ-QKQQVEKMEQ--DHAVRRRE 637
Query: 355 SPRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACRKRHL---H 411
R+ +LE+ R ++Q ++ + + ++ + R+Q +++++ E +K+ L
Sbjct: 638 EARRIRLEQDRDYTRFQEQLKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRD 697
Query: 412 AVEGQKKVQDTNLSSLINYQARKVL---MDCQAKAEELLR-------QLSLEQSFQRSQE 461
V QK+ + + L R++ +C K +ELLR ++ Q +R Q
Sbjct: 698 FVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQELLRDREAALWEMEEHQLQERHQL 757
Query: 462 IHQGLRKE---RQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQAR 518
+ Q L+ + ++ EL K +KE EQ+Q+ R E + R+ +++ + KI+++
Sbjct: 758 VKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIEQLKVRQQQEKARL----PKIQRSE 813
Query: 519 SHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQG 578
K H+ E+ I + ++E++ E +++ K + Q ++Q
Sbjct: 814 GKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQ- 872
Query: 579 KDPNFQEFQKL 589
+ N E Q+L
Sbjct: 873 CESNMSELQQL 883
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.127 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,977,775
Number of Sequences: 37866
Number of extensions: 1614737
Number of successful extensions: 22331
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 295
Number of HSP's successfully gapped in prelim test: 1295
Number of HSP's that attempted gapping in prelim test: 10478
Number of HSP's gapped (non-prelim): 5715
length of query: 623
length of database: 18,247,518
effective HSP length: 108
effective length of query: 515
effective length of database: 14,157,990
effective search space: 7291364850
effective search space used: 7291364850
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.