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Search of human proteins with 223972653
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223972653 aldehyde dehydrogenase 16 family, member A1
isoform 2 [Homo sapiens]
(751 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform... 1525 0.0
gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform... 1501 0.0
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens] 140 4e-33
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens] 140 4e-33
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho... 139 1e-32
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens] 135 1e-31
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens] 135 2e-31
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens] 135 2e-31
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens] 133 5e-31
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens] 125 1e-28
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens] 123 5e-28
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap... 113 7e-25
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens] 111 3e-24
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ... 110 6e-24
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa... 109 8e-24
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo... 100 4e-21
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens] 77 6e-14
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa... 70 5e-12
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 50 8e-06
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 50 8e-06
gi|57222568 myeloid/lymphoid or mixed-lineage leukemia (trithora... 41 0.005
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens] 38 0.030
gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens] 38 0.030
gi|145309315 G protein-coupled receptor 62 [Homo sapiens] 38 0.030
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens] 38 0.039
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens] 38 0.039
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens] 38 0.039
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens] 37 0.067
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens] 36 0.15
gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens] 36 0.15
>gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform 2
[Homo sapiens]
Length = 751
Score = 1525 bits (3949), Expect = 0.0
Identities = 751/751 (100%), Positives = 751/751 (100%)
Query: 1 MAATRAGPRAREIFTSLEYGPVPESHACALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQ 60
MAATRAGPRAREIFTSLEYGPVPESHACALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQ
Sbjct: 1 MAATRAGPRAREIFTSLEYGPVPESHACALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQ 60
Query: 61 DPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLW 120
DPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLW
Sbjct: 61 DPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLW 120
Query: 121 TLESLVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPMGVIGLILPPTFSFL 180
TLESLVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPMGVIGLILPPTFSFL
Sbjct: 121 TLESLVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPMGVIGLILPPTFSFL 180
Query: 181 EMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPFPGILNVLSGPASLVPILASQ 240
EMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPFPGILNVLSGPASLVPILASQ
Sbjct: 181 EMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPFPGILNVLSGPASLVPILASQ 240
Query: 241 PGIRKVAFCGAPEGGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARGAAACD 300
PGIRKVAFCGAPEGGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARGAAACD
Sbjct: 241 PGIRKVAFCGAPEGGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARGAAACD 300
Query: 301 LVQRFVREAQSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRT 360
LVQRFVREAQSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRT
Sbjct: 301 LVQRFVREAQSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRT 360
Query: 361 AKEALLVANGTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESG 420
AKEALLVANGTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESG
Sbjct: 361 AKEALLVANGTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESG 420
Query: 421 CSWHGGPDGLYEYLRPSGTPARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAPPYGLF 480
CSWHGGPDGLYEYLRPSGTPARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAPPYGLF
Sbjct: 421 CSWHGGPDGLYEYLRPSGTPARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAPPYGLF 480
Query: 481 VGGRFQAPGARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAAL 540
VGGRFQAPGARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAAL
Sbjct: 481 VGGRFQAPGARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAAL 540
Query: 541 LWALAAALERRKSTLASRLERQGAELKAAEAEVELSARRLRAWGARVQAQGHTLQVAGLR 600
LWALAAALERRKSTLASRLERQGAELKAAEAEVELSARRLRAWGARVQAQGHTLQVAGLR
Sbjct: 541 LWALAAALERRKSTLASRLERQGAELKAAEAEVELSARRLRAWGARVQAQGHTLQVAGLR 600
Query: 601 GPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMA 660
GPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMA
Sbjct: 601 GPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMA 660
Query: 661 TVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRGC 720
TVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRGC
Sbjct: 661 TVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRGC 720
Query: 721 PRAWDQEAEGAGPELGLRVARTKALWLPMGD 751
PRAWDQEAEGAGPELGLRVARTKALWLPMGD
Sbjct: 721 PRAWDQEAEGAGPELGLRVARTKALWLPMGD 751
>gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform 1
[Homo sapiens]
Length = 802
Score = 1501 bits (3887), Expect = 0.0
Identities = 751/802 (93%), Positives = 751/802 (93%), Gaps = 51/802 (6%)
Query: 1 MAATRAGPRAREIFTSLEYGPVPESHACALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQ 60
MAATRAGPRAREIFTSLEYGPVPESHACALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQ
Sbjct: 1 MAATRAGPRAREIFTSLEYGPVPESHACALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQ 60
Query: 61 DPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLW 120
DPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLW
Sbjct: 61 DPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLW 120
Query: 121 TLESLVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPMGVIGLILPPTFSFL 180
TLESLVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPMGVIGLILPPTFSFL
Sbjct: 121 TLESLVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPMGVIGLILPPTFSFL 180
Query: 181 EMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPFPGILNVLSGPASLVPILASQ 240
EMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPFPGILNVLSGPASLVPILASQ
Sbjct: 181 EMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPFPGILNVLSGPASLVPILASQ 240
Query: 241 PGIRKVAFCGAPE----------------------------------------------- 253
PGIRKVAFCGAPE
Sbjct: 241 PGIRKVAFCGAPEEGRALRRSLAGECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWS 300
Query: 254 ----GGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARGAAACDLVQRFVREA 309
GGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARGAAACDLVQRFVREA
Sbjct: 301 DRGPGGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARGAAACDLVQRFVREA 360
Query: 310 QSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVAN 369
QSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVAN
Sbjct: 361 QSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVAN 420
Query: 370 GTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDG 429
GTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDG
Sbjct: 421 GTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDG 480
Query: 430 LYEYLRPSGTPARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAPPYGLFVGGRFQAPG 489
LYEYLRPSGTPARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAPPYGLFVGGRFQAPG
Sbjct: 481 LYEYLRPSGTPARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAPPYGLFVGGRFQAPG 540
Query: 490 ARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAALLWALAAALE 549
ARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAALLWALAAALE
Sbjct: 541 ARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAALLWALAAALE 600
Query: 550 RRKSTLASRLERQGAELKAAEAEVELSARRLRAWGARVQAQGHTLQVAGLRGPVLRLREP 609
RRKSTLASRLERQGAELKAAEAEVELSARRLRAWGARVQAQGHTLQVAGLRGPVLRLREP
Sbjct: 601 RRKSTLASRLERQGAELKAAEAEVELSARRLRAWGARVQAQGHTLQVAGLRGPVLRLREP 660
Query: 610 LGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFPAGLAN 669
LGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFPAGLAN
Sbjct: 661 LGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFPAGLAN 720
Query: 670 VVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRGCPRAWDQEAE 729
VVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRGCPRAWDQEAE
Sbjct: 721 VVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRGCPRAWDQEAE 780
Query: 730 GAGPELGLRVARTKALWLPMGD 751
GAGPELGLRVARTKALWLPMGD
Sbjct: 781 GAGPELGLRVARTKALWLPMGD 802
>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
Length = 480
Score = 140 bits (353), Expect = 4e-33
Identities = 113/427 (26%), Positives = 185/427 (43%), Gaps = 38/427 (8%)
Query: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAF---KGWSAHPGV 99
++N +W E P +P TGE + +A D+ AV+AAR+AF W
Sbjct: 41 FINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDAS 100
Query: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA--------- 150
R + L +LA+++++ + +L T+ESL G+ + D+Q + Y+A
Sbjct: 101 ERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGM 160
Query: 151 -IQASTQEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAPLL 209
I EP+GV G I+P F L W+I PAL G TVV + PA PL
Sbjct: 161 TIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVV--IKPAEQTPLS 218
Query: 210 LAQLAGELGPFPGILNVLSGPASLVPILASQPG-IRKVAFCGAP---------------- 252
+ + ++ +G ++L + G + F A
Sbjct: 219 ALYMGALIKEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQ 278
Query: 253 ----EGGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGAR-GAAACDLVQRFVR 307
G R+ ++ES+++E +RR ER R G D + G + + + ++
Sbjct: 279 GQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQ 338
Query: 308 EAQSQGAQVFQAGDVPSERPFY-PPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALL 366
++GA++ G + F+ PT+ SN+ A+ E+ PV F+T E +
Sbjct: 339 SGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIE 398
Query: 367 VANGTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGG 426
AN + G A+V++ + +AL + +Q GTVWIN + + P GG K SG G
Sbjct: 399 RANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMG 458
Query: 427 PDGLYEY 433
GL EY
Sbjct: 459 EFGLREY 465
Score = 67.0 bits (162), Expect = 6e-11
Identities = 65/210 (30%), Positives = 91/210 (43%), Gaps = 17/210 (8%)
Query: 458 AVPSTLPAGPEIGPSPAPPYGL-----FVGGRFQAPGARSSRPIRD-SSGNLHGYVAEGG 511
A P+ L A + PSP P + F+ +Q + P+ + ++G V E
Sbjct: 14 ADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEAD 73
Query: 512 AKDIRGAVEAAHQAFP---GWAGQSPGARAALLWALAAALERRKSTLASRLERQGAELKA 568
DI AV+AA AF W R LL LA +ER ++ LA+ G +
Sbjct: 74 KADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFL 133
Query: 569 AEAEVELSA-----RRLRAWGARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPL 623
V+L R W ++ G T+ V G R EP+GV + P +PL
Sbjct: 134 QAFYVDLQGVIKTFRYYAGWADKIH--GMTIPVDGDYFTFTR-HEPIGVCGQIIPWNFPL 190
Query: 624 LAFVSLLAPALAYGNTVVMVPSAACPLLAL 653
L F +APAL GNTVV+ P+ PL AL
Sbjct: 191 LMFAWKIAPALCCGNTVVIKPAEQTPLSAL 220
>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
Length = 518
Score = 140 bits (353), Expect = 4e-33
Identities = 131/467 (28%), Positives = 197/467 (42%), Gaps = 80/467 (17%)
Query: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAF---KGWSAHPGV 99
++N +W E P +P TGE + +A D+ AV+AAR+AF W
Sbjct: 41 FINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDAS 100
Query: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA--------- 150
R + L +LA+++++ + +L T+ESL G+ + D+Q + Y+A
Sbjct: 101 ERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGM 160
Query: 151 -IQASTQEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAP-- 207
I EP+GV G I+P F L W+I PAL G TVV + PA P
Sbjct: 161 TIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVV--IKPAEQTPLS 218
Query: 208 -LLLAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEGGLRLLIQESVW 265
L + L E G PG++N+L G +AS GI K+AF G+ E G LIQE+
Sbjct: 219 ALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVG--KLIQEAAG 276
Query: 266 DEAMRRLQERMGR-----LRSGRGLDGAVDMGARGA----AAC---------------DL 301
++R+ +G + + LD AV+ +G C +
Sbjct: 277 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF 336
Query: 302 VQRFVREAQ------------SQGAQV-----------FQAGDVPSERP----------- 327
V+R V A+ QG Q+ Q+G +
Sbjct: 337 VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG 396
Query: 328 -FYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQ 386
F PT+ SN+ A+ E+ PV F+T E + AN + G A+V++ + +
Sbjct: 397 FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINK 456
Query: 387 ALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEY 433
AL + +Q GTVWIN + + P GG K SG G GL EY
Sbjct: 457 ALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREY 503
Score = 79.7 bits (195), Expect = 9e-15
Identities = 82/278 (29%), Positives = 118/278 (42%), Gaps = 19/278 (6%)
Query: 458 AVPSTLPAGPEIGPSPAPPYGL-----FVGGRFQAPGARSSRPIRD-SSGNLHGYVAEGG 511
A P+ L A + PSP P + F+ +Q + P+ + ++G V E
Sbjct: 14 ADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEAD 73
Query: 512 AKDIRGAVEAAHQAFP---GWAGQSPGARAALLWALAAALERRKSTLASRLERQGAELKA 568
DI AV+AA AF W R LL LA +ER ++ LA+ G +
Sbjct: 74 KADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFL 133
Query: 569 AEAEVELSA-----RRLRAWGARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPL 623
V+L R W ++ G T+ V G R EP+GV + P +PL
Sbjct: 134 QAFYVDLQGVIKTFRYYAGWADKIH--GMTIPVDGDYFTFTR-HEPIGVCGQIIPWNFPL 190
Query: 624 LAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATV-FPAGLANVVTGDRDHLTRCL 682
L F +APAL GNTVV+ P+ PL AL + + FP G+ N++ G +
Sbjct: 191 LMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAI 250
Query: 683 ALHQDVQAMWYFGSAQ-GSQFVEWASAGNLKPVWASRG 719
A H + + + GS + G E A NLK V G
Sbjct: 251 ASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELG 288
>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
sapiens]
Length = 517
Score = 139 bits (349), Expect = 1e-32
Identities = 135/507 (26%), Positives = 216/507 (42%), Gaps = 83/507 (16%)
Query: 2 AATRAGPR-AREIFTSLEYGPVPESHACALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQ 60
AA R GPR R + ++ VP + + C ++N +W R + P
Sbjct: 4 AAARFGPRLGRRLLSAAATQAVPAPNQ------QPEVFCNQIFINNEWHDAVSRKTFPTV 57
Query: 61 DPITGENLASCLQAQAEDVAAAVEAARMAFK---GWSAHPGVVRAQHLTRLAEVIQKHQR 117
+P TGE + + EDV AV+AAR AF+ W R + L RLA++I++ +
Sbjct: 58 NPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRT 117
Query: 118 LLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA----------IQASTQEEALAGWEPMG 167
L LE+L G+ D+ + + L Y+A I + EP+G
Sbjct: 118 YLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVG 177
Query: 168 VIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASP-APLLLAQLAGELGPFPGILNV 226
V G I+P F L W++ PALA G VV V +P L +A L E G PG++N+
Sbjct: 178 VCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNI 237
Query: 227 LSG-PASLVPILASQPGIRKVAFCGAPEGGLRLLIQESVWDEAMRRLQERMGR-----LR 280
+ G + +AS + KVAF G+ E G +IQ + ++R+ +G +
Sbjct: 238 VPGFGPTAGAAIASHEDVDKVAFTGSTEIG--RVIQVAAGSSNLKRVTLELGGKSPNIIM 295
Query: 281 SGRGLDGAVDMG------ARGAAAC-------------DLVQRFVREAQS---------- 311
S +D AV+ +G C + V+R V A+S
Sbjct: 296 SDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSK 355
Query: 312 ------------------------QGAQVFQAGDVPSERPFY-PPTLVSNLPPASPCAQV 346
+GA++ G + ++R ++ PT+ ++ A+
Sbjct: 356 TEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKE 415
Query: 347 EVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGL 406
E+ PV+ F+T +E + AN + G +A+V+++ L +A L LQ GTVW+N + +
Sbjct: 416 EIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDV 475
Query: 407 RDPSVPTGGCKESGCSWHGGPDGLYEY 433
P GG K SG G GL Y
Sbjct: 476 FGAQSPFGGYKMSGSGRELGEYGLQAY 502
Score = 81.6 bits (200), Expect = 2e-15
Identities = 75/250 (30%), Positives = 119/250 (47%), Gaps = 10/250 (4%)
Query: 479 LFVGGRFQAPGARSSRP-IRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFP---GWAGQSP 534
+F+ + +R + P + S+G + VAEG +D+ AV+AA AF W
Sbjct: 39 IFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDA 98
Query: 535 GARAALLWALAAALERRKSTLAS--RLERQGAELKAAEAEVELSARRLRAW-GARVQAQG 591
R LL LA +ER ++ LA+ L+ + + ++++ + LR + G + G
Sbjct: 99 SHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHG 158
Query: 592 HTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLL 651
T+ + G R EP+GV + P +PLL L PALA GN VVM + PL
Sbjct: 159 KTIPIDGDFFSYTR-HEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLT 217
Query: 652 ALEVCQDMATV-FPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWAS-AG 709
AL V + FP G+ N+V G +A H+DV + + GS + + ++ A+ +
Sbjct: 218 ALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSS 277
Query: 710 NLKPVWASRG 719
NLK V G
Sbjct: 278 NLKRVTLELG 287
>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
Length = 501
Score = 135 bits (341), Expect = 1e-31
Identities = 132/478 (27%), Positives = 204/478 (42%), Gaps = 80/478 (16%)
Query: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFK---GWSAHPGV 99
++N +W P +P T E L + EDV AV+AAR AF+ W
Sbjct: 24 FINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDAS 83
Query: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA-----IQAS 154
R + L +LA++I++ + LL T+ES+ G+ D+ + L Y A IQ
Sbjct: 84 ERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGR 143
Query: 155 T-----QEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAPLL 209
T EP+GV G I+P F + ++W+I PAL+ G TVV V PA PL
Sbjct: 144 TIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVV--VKPAEQTPLT 201
Query: 210 ---LAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEGGLRLLIQESVW 265
+A L E G PG++N++ G ++S I KVAF G+ E G LI+E+
Sbjct: 202 ALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVG--KLIKEAAG 259
Query: 266 DEAMRRLQERMGR-----LRSGRGLDGAVDMGARGA----AAC---------------DL 301
++R+ +G + + LD AV+ G C +
Sbjct: 260 KSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEF 319
Query: 302 VQRFVREAQ------------SQGAQV---------------------FQAGDVP--SER 326
V+R V A+ +QG Q+ + G P ++
Sbjct: 320 VRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKG 379
Query: 327 PFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQ 386
F PT+ SN+ A+ E+ PV F++ + + AN T G SA V+++ + +
Sbjct: 380 YFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDK 439
Query: 387 ALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLRPSGTPARLS 444
A+ + LQ GTVW+N +G+ P GG K SG G G +EY ++S
Sbjct: 440 AITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKIS 497
Score = 89.0 bits (219), Expect = 1e-17
Identities = 70/223 (31%), Positives = 103/223 (46%), Gaps = 13/223 (5%)
Query: 507 VAEGGAKDIRGAVEAAHQAFP---GWAGQSPGARAALLWALAAALERRKSTLASRLERQG 563
V EG +D+ AV+AA QAF W R LL+ LA +ER + LA+ G
Sbjct: 52 VEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNG 111
Query: 564 AELKAAEAEVELSA-----RRLRAWGARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCP 618
+L + +L+ R W ++Q G T+ + G R EP+GV + P
Sbjct: 112 GKLYSNAYLNDLAGCIKTLRYCAGWADKIQ--GRTIPIDGNFFTYTR-HEPIGVCGQIIP 168
Query: 619 DEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATV-FPAGLANVVTGDRDH 677
+PL+ + + PAL+ GNTVV+ P+ PL AL V + FP G+ N+V G
Sbjct: 169 WNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPT 228
Query: 678 LTRCLALHQDVQAMWYFGSAQ-GSQFVEWASAGNLKPVWASRG 719
++ H D+ + + GS + G E A NLK V G
Sbjct: 229 AGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELG 271
>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
Length = 487
Score = 135 bits (339), Expect = 2e-31
Identities = 118/465 (25%), Positives = 198/465 (42%), Gaps = 78/465 (16%)
Query: 40 LGHYVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGV 99
L ++++GK+L + + DP TGE + +++ AAV+AAR AF WS+
Sbjct: 10 LENFIDGKFLPCS--SYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQ 67
Query: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHY------HAIQA 153
R++ L ++A+++++ ES G+ + R D+ + Q + H
Sbjct: 68 ERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSE 127
Query: 154 STQEEALAGWE-----PMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPP-ASPAP 207
TQ + L P+GV GLI P + W+I PA+A G TV+A S
Sbjct: 128 CTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTA 187
Query: 208 LLLAQLAGELGPFPGILNVLSGPAS-------------LVPILASQPGIRKVAFCGAPE- 253
+L +L + G PG++N++ G L+ SQP ++ AP
Sbjct: 188 WMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHC 247
Query: 254 -------GGL----------------------------------RLLIQESVWDEAMRRL 272
GG R+ +Q+S++ E ++R
Sbjct: 248 KKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRF 307
Query: 273 QERMGRLRSGRGLDGAVDMGAR-GAAACDLVQRFVREAQSQGAQVFQAGDV-----PSER 326
E + + G D V +GA A + V+ +V+ A ++GAQ++ V P+
Sbjct: 308 VEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARN 367
Query: 327 P---FYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSER 383
F PT+++++ S C E+ PV PF + +E + AN G +A+VWS
Sbjct: 368 QAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSN 427
Query: 384 LGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPD 428
+G+ + LQ G VW N +R+ ++P GG K SG G D
Sbjct: 428 VGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKD 472
Score = 83.6 bits (205), Expect = 6e-16
Identities = 68/238 (28%), Positives = 112/238 (47%), Gaps = 7/238 (2%)
Query: 480 FVGGRFQAPGARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAA 539
F+ G+F P + S+G ++ V G +I AV+AA +AFP W+ +SP R+
Sbjct: 13 FIDGKF-LPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERSR 71
Query: 540 LLWALAAALERRKSTLA-SRLERQGAELKAAEA-EVELSARRLRAW-GARVQAQGHTLQV 596
+L +A LE+ A + + QG L A ++ S + R + + + Q+
Sbjct: 72 VLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQM 131
Query: 597 AGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVC 656
L +R P+GV ++ P PL +APA+A GNTV+ PS + A +C
Sbjct: 132 DHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLC 191
Query: 657 Q--DMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLK 712
+ D A V P G+ N+V G + L H +V + + GS ++ + SA + K
Sbjct: 192 KLLDKAGV-PPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCK 248
>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
Length = 517
Score = 135 bits (339), Expect = 2e-31
Identities = 126/465 (27%), Positives = 197/465 (42%), Gaps = 76/465 (16%)
Query: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFK---GWSAHPGV 99
++N +W + + P +P TGE + + DV AV+AAR AF+ W
Sbjct: 40 FINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDAS 99
Query: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA--------- 150
R + L RLA+++++ + L +LE+L G+ +E D+ ++ Y A
Sbjct: 100 ERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGK 159
Query: 151 -IQASTQEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASP-APL 208
I Q EP+GV G I+P F + W++ PALA G TVV V +P + L
Sbjct: 160 TIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSAL 219
Query: 209 LLAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEGGLRLLIQESVWDE 267
LA L E G PG++N+++G +A + KVAF G+ E G LIQ++ D
Sbjct: 220 YLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVG--HLIQKAAGDS 277
Query: 268 AMRRLQERMGR-----LRSGRGLDGAVDMGAR------GAAACDLVQRFVREA------- 309
++R+ +G + + ++ AV+ G C + FV E+
Sbjct: 278 NLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLE 337
Query: 310 ------------------QSQGAQVFQ----------------------AGDVPSERPFY 329
QG QV + G+ ER F+
Sbjct: 338 RTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFF 397
Query: 330 -PPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQAL 388
PT+ + A+ E+ PV F+ +E + AN T G +A+V++ L +A+
Sbjct: 398 IKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAM 457
Query: 389 ELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEY 433
LQ GTVW+N + + P GG KESG G DGL Y
Sbjct: 458 YFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAY 502
Score = 88.2 bits (217), Expect = 3e-17
Identities = 92/293 (31%), Positives = 134/293 (45%), Gaps = 25/293 (8%)
Query: 440 PARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAPPYG-LFVGGRFQAPGARSSRP-IR 497
P LS + Y + A+PS + P+I PY LF+ +Q ++ + P +
Sbjct: 7 PRLLSLQGRTARYSS-AAALPSPI-LNPDI------PYNQLFINNEWQDAVSKKTFPTVN 58
Query: 498 DSSGNLHGYVAEGGAKDIRGAVEAAHQAF---PGWAGQSPGARAALLWALAAALERRKST 554
++G + G+VAEG D+ AV+AA +AF W R LL LA +ER +
Sbjct: 59 PTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVY 118
Query: 555 LASRLER--QGAELKAAEA----EVELSARRLRAWGARVQAQGHTLQVAGLRGPVLRLRE 608
LAS LE G + + A EV R W + G T+ + G R E
Sbjct: 119 LAS-LETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWH--GKTIPMDGQHFCFTR-HE 174
Query: 609 PLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATV-FPAGL 667
P+GV + P +PL+ LAPALA GNTVVM + PL AL + + FP G+
Sbjct: 175 PVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGV 234
Query: 668 ANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASA-GNLKPVWASRG 719
N++TG +A H DV + + GS + ++ A+ NLK V G
Sbjct: 235 VNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELG 287
>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
Length = 433
Score = 133 bits (335), Expect = 5e-31
Identities = 111/415 (26%), Positives = 190/415 (45%), Gaps = 32/415 (7%)
Query: 40 LGHYVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGV 99
L ++++GK+L + + DP TGE + +++ AAV+AAR AF WS+
Sbjct: 10 LENFIDGKFLPCS--SYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQ 67
Query: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHY------HAIQA 153
R++ L ++A+++++ ES G+ + R D+ + Q + H
Sbjct: 68 ERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSE 127
Query: 154 STQEEALAGWE-----PMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPP-ASPAP 207
TQ + L P+GV GLI P + W+I PA+A G TV+A S
Sbjct: 128 CTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTA 187
Query: 208 LLLAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEGGLRLLIQESVWD 266
+L +L + G PG++N++ G V L S P + ++F G+ R+ +
Sbjct: 188 WMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA--- 244
Query: 267 EAMRRLQERMGR-----LRSGRGLDGAVDMGARGAAACDLVQRFVREAQSQGAQVFQAGD 321
++L +G + LD + R + A + V+ +V+ A ++GAQ++
Sbjct: 245 PHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFA-NQVRSYVKRALAEGAQIWCGEG 303
Query: 322 V-----PSERP---FYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPR 373
V P+ F PT+++++ S C E+ PV PF + +E + AN
Sbjct: 304 VDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKY 363
Query: 374 GGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPD 428
G +A+VWS +G+ + LQ G VW N +R+ ++P GG K SG G D
Sbjct: 364 GLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKD 418
Score = 83.6 bits (205), Expect = 6e-16
Identities = 68/238 (28%), Positives = 112/238 (47%), Gaps = 7/238 (2%)
Query: 480 FVGGRFQAPGARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAA 539
F+ G+F P + S+G ++ V G +I AV+AA +AFP W+ +SP R+
Sbjct: 13 FIDGKF-LPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERSR 71
Query: 540 LLWALAAALERRKSTLA-SRLERQGAELKAAEA-EVELSARRLRAW-GARVQAQGHTLQV 596
+L +A LE+ A + + QG L A ++ S + R + + + Q+
Sbjct: 72 VLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQM 131
Query: 597 AGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVC 656
L +R P+GV ++ P PL +APA+A GNTV+ PS + A +C
Sbjct: 132 DHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLC 191
Query: 657 Q--DMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLK 712
+ D A V P G+ N+V G + L H +V + + GS ++ + SA + K
Sbjct: 192 KLLDKAGV-PPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCK 248
>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
Length = 512
Score = 125 bits (315), Expect = 1e-28
Identities = 122/467 (26%), Positives = 195/467 (41%), Gaps = 80/467 (17%)
Query: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKG---WSAHPGV 99
++N +W + + +P T E + + DV AVEAA++AF+ W +
Sbjct: 35 FINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDAL 94
Query: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA-----IQAS 154
R + L +LA+++++ + L LE++ TG+ D++ + L Y A IQ
Sbjct: 95 SRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGK 154
Query: 155 T-----QEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAP-- 207
T EP+GV G I P F L ++W++ PAL G T+V + PA P
Sbjct: 155 TIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMV--LKPAEQTPLT 212
Query: 208 -LLLAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEGGLRLLIQESVW 265
L L L E G PG++N++ G V ++S P I K+AF G+ E G L++E+
Sbjct: 213 ALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVG--KLVKEAAS 270
Query: 266 DEAMRRLQERMGR-----LRSGRGLDGAVDMGARG-----AAACDLVQRFVREAQSQGAQ 315
++R+ +G + + LD AV+ +G C R E Q
Sbjct: 271 RSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEF 330
Query: 316 VFQAGDVPSERP------------------------------------------------ 327
V ++ + +RP
Sbjct: 331 VRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKG 390
Query: 328 -FYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQ 386
F PT+ S + A+ E+ PV F++ +E + AN T G +A+V+++ L +
Sbjct: 391 LFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDK 450
Query: 387 ALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEY 433
AL+L L+ GTVWIN + P GG K SG G L EY
Sbjct: 451 ALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEY 497
Score = 80.9 bits (198), Expect = 4e-15
Identities = 74/223 (33%), Positives = 105/223 (47%), Gaps = 13/223 (5%)
Query: 507 VAEGGAKDIRGAVEAAHQAFPG---WAGQSPGARAALLWALAAALERRKSTLAS--RLER 561
V EG D+ AVEAA AF W +R LL LA +ER ++TLA+ ++
Sbjct: 63 VEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDT 122
Query: 562 QGAELKAAEAEVELSARRLR---AWGARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCP 618
L A ++E R LR W ++Q G T+ R EP+GV + P
Sbjct: 123 GKPFLHAFFIDLEGCIRTLRYFAGWADKIQ--GKTIPTDDNVVCFTR-HEPIGVCGAITP 179
Query: 619 DEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATV-FPAGLANVVTGDRDH 677
+PLL V LAPAL GNT+V+ P+ PL AL + + FP G+ N+V G
Sbjct: 180 WNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPT 239
Query: 678 LTRCLALHQDVQAMWYFGSAQGSQFV-EWASAGNLKPVWASRG 719
+ ++ H + + + GS + + V E AS NLK V G
Sbjct: 240 VGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELG 282
>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
Length = 518
Score = 123 bits (309), Expect = 5e-28
Identities = 118/439 (26%), Positives = 192/439 (43%), Gaps = 74/439 (16%)
Query: 61 DPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLW 120
+P TG +A+ + ++V AV+ A+ AFK WS G+ R + L A +I++ + +
Sbjct: 57 EPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIA 116
Query: 121 TLESLVTGRAVREVRDGDVQLAQQLLHYHA-IQASTQEEALA------GW---EPMGVIG 170
T+E + G+++ E R D+ ++ Q L Y+A + AS E + G+ EP+GV
Sbjct: 117 TMECINNGKSIFEAR-LDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCV 175
Query: 171 LILPPTFSFLEMMWRICPALAVGCTVVALVPPASP-APLLLAQLAGELGPFPGILNVLSG 229
I + F W+ PALA G +V P +P + LLLA++ E G PG+ NV+ G
Sbjct: 176 GIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG 235
Query: 230 PASLVPILASQPGIRKVAFCGA-PEG---------------------------------- 254
A+ L P + KV+F G+ P G
Sbjct: 236 GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNN 295
Query: 255 -------------------GLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGAR- 294
G R+ +Q+ + D+ + ++ R++ G L MG
Sbjct: 296 AVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLI 355
Query: 295 GAAACDLVQRFVREAQSQGAQVFQAGDV-PSERP------FYPPTLVSNLPPASPCAQVE 347
+ V FV+ A+ QGA+V GD+ E P + P +++N C + E
Sbjct: 356 NRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEE 415
Query: 348 VPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLR 407
+ PV+ F T E L AN T G +A V++ + +A + LQ GT +IN + +
Sbjct: 416 IFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVS 475
Query: 408 DPSVPTGGCKESGCSWHGG 426
+P GG K+SG G
Sbjct: 476 PVELPFGGYKKSGFGRENG 494
Score = 68.9 bits (167), Expect = 2e-11
Identities = 76/277 (27%), Positives = 114/277 (41%), Gaps = 15/277 (5%)
Query: 456 GLAVPSTLPAGPEIGPSPAPPYGLFV---------GGRFQ-APGARSSRPIRDSSGNLHG 505
GLA S L P A G FV G R + A + + + ++G +
Sbjct: 6 GLAALSPLLRSLRPSPVAAMSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIA 65
Query: 506 YVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAALLWALAAALERRKSTLAS-RLERQGA 564
G K++ AV+ A AF W+ +S R +L A + R+ +A+ G
Sbjct: 66 TFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGK 125
Query: 565 ELKAAEAEVELSARRLRAW-GARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPL 623
+ A ++++S + L + G G +Q+ G R REPLGV + +P
Sbjct: 126 SIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTR-REPLGVCVGIGAWNYPF 184
Query: 624 LAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATV-FPAGLANVVTGDRDHLTRCL 682
APALA GN +V PS P+ AL + + + P GL NVV G + L
Sbjct: 185 QIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGA-ATGQFL 243
Query: 683 ALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRG 719
H DV + + GS + SA +KPV G
Sbjct: 244 CQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELG 280
>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
sapiens]
Length = 902
Score = 113 bits (282), Expect = 7e-25
Identities = 124/472 (26%), Positives = 197/472 (41%), Gaps = 81/472 (17%)
Query: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKG--WSAHPGVV 100
++ G+++ E + +P G + AQ DV AV AA+ AF+ W
Sbjct: 425 FIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARD 484
Query: 101 RAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA-----IQAST 155
R + + RLA+++++HQ L T+E+L G V ++ Q Y A IQ ST
Sbjct: 485 RGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGST 544
Query: 156 ---------QEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPA 206
+ L EP+GV G+I+P + + + W+ LA G TVV + PA
Sbjct: 545 IPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVV--IKPAQVT 602
Query: 207 P---LLLAQLA-------GELGPFPG---------------------------------- 222
P L A+L G + PG
Sbjct: 603 PLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSC 662
Query: 223 -ILNV------LSGPASLVPIL------ASQPGIRKVAFCGAPE--GGLRLLIQESVWDE 267
I NV L G + L+ A Q G+ V F RL +++S+ DE
Sbjct: 663 AISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDE 722
Query: 268 AMRRLQERMGRLRSGRGLDGAVDMGARGAAACDL-VQRFVREAQSQGAQVFQAGD-VPSE 325
+RR+ E + +++ G LD D G + A + + + + +GA + G+ VP
Sbjct: 723 FVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRP 782
Query: 326 RPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAK--EALLVANGTPRGGSASVWSER 383
F+ PT+ +++ A+ E PV++ S F L AN T G ++ V++
Sbjct: 783 GFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTRD 842
Query: 384 LGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLR 435
+ +AL + LQ GTV++N + D + P GG K+SG G L EYLR
Sbjct: 843 INKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLR 894
Score = 94.0 bits (232), Expect = 5e-19
Identities = 76/250 (30%), Positives = 122/250 (48%), Gaps = 11/250 (4%)
Query: 476 PYGLFVGGRF-QAPGARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPG--WAGQ 532
P+ LF+GG F A GA++S I + G++ V+ D+ AV AA AF W
Sbjct: 421 PHQLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKI 480
Query: 533 SPGARAALLWALAAALERRKSTLAS--RLERQGAELKAAEAEVELSARRLRAW-GARVQA 589
S R L++ LA +E+ + LA+ L+ A + V +S + R + G +
Sbjct: 481 SARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKI 540
Query: 590 QGHTL---QVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSA 646
QG T+ Q R L +EP+GV ++ P +PL+ A LA GNTVV+ P+
Sbjct: 541 QGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQ 600
Query: 647 ACPLLALEVCQ-DMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQ-GSQFVE 704
PL AL+ + + P G+ NV+ G + + L+ H DV+ + + GS + G ++
Sbjct: 601 VTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMK 660
Query: 705 WASAGNLKPV 714
+ N+K V
Sbjct: 661 SCAISNVKKV 670
>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
Length = 422
Score = 111 bits (277), Expect = 3e-24
Identities = 113/406 (27%), Positives = 170/406 (41%), Gaps = 77/406 (18%)
Query: 101 RAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA---------- 150
R + L +LA+++++ + +L T+ESL G+ + D+Q + Y+A
Sbjct: 6 RGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMT 65
Query: 151 IQASTQEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAP--- 207
I EP+GV G I+P F L W+I PAL G TVV + PA P
Sbjct: 66 IPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVV--IKPAEQTPLSA 123
Query: 208 LLLAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEGGLRLLIQESVWD 266
L + L E G PG++N+L G +AS GI K+AF G+ E G LIQE+
Sbjct: 124 LYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVG--KLIQEAAGR 181
Query: 267 EAMRRLQERMGR-----LRSGRGLDGAVDMGARGA----AAC---------------DLV 302
++R+ +G + + LD AV+ +G C + V
Sbjct: 182 SNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFV 241
Query: 303 QRFVREAQ------------SQGAQV-----------FQAGDVPSERP------------ 327
+R V A+ QG Q+ Q+G +
Sbjct: 242 RRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGF 301
Query: 328 FYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQA 387
F PT+ SN+ A+ E+ PV F+T E + AN + G A+V++ + +A
Sbjct: 302 FIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKA 361
Query: 388 LELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEY 433
L + +Q GTVWIN + + P GG K SG G GL EY
Sbjct: 362 LTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREY 407
Score = 64.7 bits (156), Expect = 3e-10
Identities = 59/190 (31%), Positives = 84/190 (44%), Gaps = 10/190 (5%)
Query: 537 RAALLWALAAALERRKSTLASRLERQGAELKAAEAEVELSA-----RRLRAWGARVQAQG 591
R LL LA +ER ++ LA+ G + V+L R W ++ G
Sbjct: 6 RGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIH--G 63
Query: 592 HTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLL 651
T+ V G R EP+GV + P +PLL F +APAL GNTVV+ P+ PL
Sbjct: 64 MTIPVDGDYFTFTR-HEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLS 122
Query: 652 ALEVCQDMATV-FPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQ-GSQFVEWASAG 709
AL + + FP G+ N++ G +A H + + + GS + G E A
Sbjct: 123 ALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRS 182
Query: 710 NLKPVWASRG 719
NLK V G
Sbjct: 183 NLKRVTLELG 192
>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
sapiens]
Length = 535
Score = 110 bits (274), Expect = 6e-24
Identities = 124/508 (24%), Positives = 197/508 (38%), Gaps = 83/508 (16%)
Query: 5 RAGPRAREIFTSLEYGPVPESHAC---ALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQD 61
R PRA + + P P C LA L +V G+WL + P QD
Sbjct: 23 RLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLRTDSFVGGRWLPAAA--TFPVQD 80
Query: 62 PITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLWT 121
P +G L + AAV AA AF W R+ L + ++ +++ L
Sbjct: 81 PASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLAR 140
Query: 122 LESLVTGRAVREVRDGDVQLAQQLLHYHAIQA-----------STQEEALAGWEPMGVIG 170
+ + +G+ ++E G++ + L + + +A + AL +P+GV
Sbjct: 141 IITAESGKPLKEAH-GEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAA 199
Query: 171 LILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAP---LLLAQLAGELGPFPGILNVL 227
+I P F + ++ ALA GCTVV V PA P L LA+LA + G G+ NV+
Sbjct: 200 VITPWNFPSAMITRKVGAALAAGCTVV--VKPAEDTPFSALALAELASQAGIPSGVYNVI 257
Query: 228 ----SGPASLVPILASQPGIRKVAFCGAPE--------------------GGL------- 256
+ + + P + K++F G+ GGL
Sbjct: 258 PCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFD 317
Query: 257 ---------------------------RLLIQESVWDEAMRRLQERMGR-LRSGRGLDGA 288
+ L+Q + D ++ E M + LR G G +
Sbjct: 318 SANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEG 377
Query: 289 VDMGAR-GAAACDLVQRFVREAQSQGAQVFQAGDVPS-ERPFYPPTLVSNLPPASPCAQV 346
G A + V++ V +A S+GA V G + F+ PTL+ N+ C
Sbjct: 378 TTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHE 437
Query: 347 EVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGL 406
E P+ F T +EA+ +AN G + +S+ Q + L+VG V +N +
Sbjct: 438 ETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLI 497
Query: 407 RDPSVPTGGCKESGCSWHGGPDGLYEYL 434
P GG K+SG G G+ EYL
Sbjct: 498 SSVECPFGGVKQSGLGREGSKYGIDEYL 525
Score = 77.4 bits (189), Expect = 4e-14
Identities = 78/281 (27%), Positives = 121/281 (43%), Gaps = 28/281 (9%)
Query: 399 VWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLRPSGTPARLSCLSKNLNYDTFGLA 458
+W+ + G R G GC GL P+ PA+L C + L + L
Sbjct: 5 IWLRSCGARRL-----GSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALL 59
Query: 459 VPSTLPAGPEIGPSPAPPYGLFVGGRFQAPGARSSRPIRD-SSGNLHGYVAEGGAKDIRG 517
+ FVGGR+ A ++ P++D +SG G VA+ G ++ R
Sbjct: 60 RTDS-----------------FVGGRWLP--AAATFPVQDPASGAALGMVADCGVREARA 100
Query: 518 AVEAAHQAFPGWAGQSPGARAALLWALAAALERRKSTLASRLERQ-GAELKAAEAEVELS 576
AV AA++AF W S R++LL + + K LA + + G LK A E+ S
Sbjct: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYS 160
Query: 577 ARRLRAWGARVQ-AQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALA 635
A L + + G + L L++P+GV AV+ P +P + ALA
Sbjct: 161 AFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALA 220
Query: 636 YGNTVVMVPSAACPLLALEVCQDMATV-FPAGLANVVTGDR 675
G TVV+ P+ P AL + + + P+G+ NV+ R
Sbjct: 221 AGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSR 261
>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
sapiens]
Length = 923
Score = 109 bits (273), Expect = 8e-24
Identities = 111/473 (23%), Positives = 199/473 (42%), Gaps = 83/473 (17%)
Query: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKG--WSAHPGVV 100
++NG++ + + +P G + A DV AV AA+ AF+ W
Sbjct: 446 FINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARE 505
Query: 101 RAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA-----IQAST 155
R + + RLA++++++Q L T+E+L +G + ++ Q Y A IQ ST
Sbjct: 506 RGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGST 565
Query: 156 ---------QEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPA 206
+ EP+GV +I+P + + + W+ LA G T+V + PA
Sbjct: 566 IPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLV--LKPAQVT 623
Query: 207 PLL---LAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEGGLR----- 257
PL A+L+ + G G++N++ G + L+ P IRK+ F G+ G +
Sbjct: 624 PLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSC 683
Query: 258 ------------------LLIQESVWDEAMR----------------------------- 270
++ + D+A+R
Sbjct: 684 AVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDE 743
Query: 271 ---RLQERMGRLRSGRGLDGAVDMGARG-AAACDLVQRFVREAQSQGAQVFQAGDVPSER 326
R+ E + +++ G LD + D G + A + + ++ +GA + G +R
Sbjct: 744 FVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGR-QVQR 802
Query: 327 P--FYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTA--KEALLVANGTPRGGSASVWSE 382
P F PT+ +++ A+ E P++V S F+ L AN T G ++ V++
Sbjct: 803 PGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTR 862
Query: 383 RLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLR 435
+ +A+ + L+ GTV+IN + D + P GG K+SG G + L EYL+
Sbjct: 863 DINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLK 915
Score = 89.7 bits (221), Expect = 9e-18
Identities = 72/250 (28%), Positives = 116/250 (46%), Gaps = 11/250 (4%)
Query: 476 PYGLFVGGRF-QAPGARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPG--WAGQ 532
PY F+ G+F A ++ I + G+ V+ D+ AV AA AF W
Sbjct: 442 PYQCFINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRM 501
Query: 533 SPGARAALLWALAAALERRKSTLAS--RLERQGAELKAAEAEVELSARRLRAW-GARVQA 589
+ R L++ LA LE + LA+ L+ A + + +S + R + G +
Sbjct: 502 NARERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKI 561
Query: 590 QGHTL---QVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSA 646
QG T+ Q R +EPLGV A++ P +PL+ A LA GNT+V+ P+
Sbjct: 562 QGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQ 621
Query: 647 ACPLLALEVCQ-DMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQ-GSQFVE 704
PL AL+ + + FP G+ N++ G + L+ H D++ + + GS G Q ++
Sbjct: 622 VTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMK 681
Query: 705 WASAGNLKPV 714
+ NLK V
Sbjct: 682 SCAVSNLKKV 691
>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
sapiens]
Length = 548
Score = 100 bits (250), Expect = 4e-21
Identities = 124/521 (23%), Positives = 197/521 (37%), Gaps = 96/521 (18%)
Query: 5 RAGPRAREIFTSLEYGPVPESHAC---ALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQD 61
R PRA + + P P C LA L +V G+WL + P QD
Sbjct: 23 RLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLRTDSFVGGRWLPAAA--TFPVQD 80
Query: 62 PITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLWT 121
P +G L + AAV AA AF W R+ L + ++ +++ L
Sbjct: 81 PASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLAR 140
Query: 122 LESLVTGRAVREVRDGDVQLAQQLLHYHAIQA-----------STQEEALAGWEPMGVIG 170
+ + +G+ ++E G++ + L + + +A + AL +P+GV
Sbjct: 141 IITAESGKPLKEAH-GEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAA 199
Query: 171 LILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAP---LLLAQ-------------LA 214
+I P F + ++ ALA GCTVV V PA P L LA+ LA
Sbjct: 200 VITPWNFPSAMITRKVGAALAAGCTVV--VKPAEDTPFSALALAEVNQGFLLDLDPLLLA 257
Query: 215 GELGPFPGILNVL----SGPASLVPILASQPGIRKVAFCGAPE----------------- 253
+ G G+ NV+ + + + P + K++F G+
Sbjct: 258 SQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVS 317
Query: 254 ---GGL----------------------------------RLLIQESVWDEAMRRLQERM 276
GGL + L+Q + D ++ E M
Sbjct: 318 MELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAM 377
Query: 277 GR-LRSGRGLDGAVDMGAR-GAAACDLVQRFVREAQSQGAQVFQAGDVPS-ERPFYPPTL 333
+ LR G G + G A + V++ V +A S+GA V G + F+ PTL
Sbjct: 378 KKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTL 437
Query: 334 VSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALELGYG 393
+ N+ C E P+ F T +EA+ +AN G + +S+ Q +
Sbjct: 438 LCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQ 497
Query: 394 LQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYL 434
L+VG V +N + P GG K+SG G G+ EYL
Sbjct: 498 LEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYL 538
Score = 73.6 bits (179), Expect = 6e-13
Identities = 73/262 (27%), Positives = 112/262 (42%), Gaps = 27/262 (10%)
Query: 399 VWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLRPSGTPARLSCLSKNLNYDTFGLA 458
+W+ + G R G GC GL P+ PA+L C + L + L
Sbjct: 5 IWLRSCGARRL-----GSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALL 59
Query: 459 VPSTLPAGPEIGPSPAPPYGLFVGGRFQAPGARSSRPIRD-SSGNLHGYVAEGGAKDIRG 517
+ FVGGR+ A ++ P++D +SG G VA+ G ++ R
Sbjct: 60 RTDS-----------------FVGGRWLP--AAATFPVQDPASGAALGMVADCGVREARA 100
Query: 518 AVEAAHQAFPGWAGQSPGARAALLWALAAALERRKSTLASRLERQ-GAELKAAEAEVELS 576
AV AA++AF W S R++LL + + K LA + + G LK A E+ S
Sbjct: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYS 160
Query: 577 ARRLRAWGARVQ-AQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALA 635
A L + + G + L L++P+GV AV+ P +P + ALA
Sbjct: 161 AFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALA 220
Query: 636 YGNTVVMVPSAACPLLALEVCQ 657
G TVV+ P+ P AL + +
Sbjct: 221 AGCTVVVKPAEDTPFSALALAE 242
>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
Length = 535
Score = 77.0 bits (188), Expect = 6e-14
Identities = 94/435 (21%), Positives = 166/435 (38%), Gaps = 80/435 (18%)
Query: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRA 102
++ GK+++ + + +P T E + QA ++ AA+ + + AF W+ + R
Sbjct: 43 FIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQ 102
Query: 103 QHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHY----------HAIQ 152
Q L R ++I+++ + + L +L G+ + + +GDV Q++ + +
Sbjct: 103 QVLLRYQQLIKENLKEIAKLITLEQGKTLADA-EGDVFRGLQVVEHACSVTSLMMGETMP 161
Query: 153 ASTQEEALAGWE-PMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAP---L 208
+ T++ L + P+GV I P F + +W A+ G T L+ P+ P +
Sbjct: 162 SITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTF--LMKPSERVPGATM 219
Query: 209 LLAQLAGELGPFPGILNVLSGPASLVPILASQP------------------------GIR 244
LLA+L + G G LN++ G V + P G R
Sbjct: 220 LLAKLLQDSGAPDGTLNIIHGQHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKR 279
Query: 245 KVAFCGAPEGG-----------LRLLIQESVWDEAMR------------------RLQER 275
A GA G L L+ + R L E
Sbjct: 280 VQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEH 339
Query: 276 MGRLRSGRGLDGAVDMGA-----RGAAACDLVQRFVREAQS---QGAQVFQAGDVPSERP 327
LR G D+G C+L+ +E S G ++ G
Sbjct: 340 AKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGN-- 397
Query: 328 FYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQA 387
F PT++SN+ P C + E+ PV+V T EA+ + N P G ++++ A
Sbjct: 398 FVGPTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATA 457
Query: 388 LELGYGLQVGTVWIN 402
+ + + VG V +N
Sbjct: 458 RKYAHLVDVGQVGVN 472
Score = 68.2 bits (165), Expect = 3e-11
Identities = 62/254 (24%), Positives = 110/254 (43%), Gaps = 9/254 (3%)
Query: 472 SPAPPYGLFVGGRFQAPGARSSRPIRDSSGN-LHGYVAEGGAKDIRGAVEAAHQAFPGWA 530
S P LF+GG+F + I + + N + G V + ++ A+ + +AFP WA
Sbjct: 35 SSVPTVKLFIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFPAWA 94
Query: 531 GQSPGARAALLWALAAALERRKSTLASRLE-RQGAELKAAEAEVELSARRLR-AWGARVQ 588
S +R +L ++ +A + QG L AE +V + + A
Sbjct: 95 DTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAEGDVFRGLQVVEHACSVTSL 154
Query: 589 AQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAAC 648
G T+ + R PLGV A + P +P + + + A+ GNT +M PS
Sbjct: 155 MMGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERV 214
Query: 649 P---LLALEVCQDMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEW 705
P +L ++ QD P G N++ G + + H D++A+ + GS + +++
Sbjct: 215 PGATMLLAKLLQDSGA--PDGTLNIIHGQHE-AVNFICDHPDIKAISFVGSNKAGEYIFE 271
Query: 706 ASAGNLKPVWASRG 719
+ + K V A+ G
Sbjct: 272 RGSRHGKRVQANMG 285
>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
sapiens]
Length = 539
Score = 70.5 bits (171), Expect = 5e-12
Identities = 108/479 (22%), Positives = 184/479 (38%), Gaps = 100/479 (20%)
Query: 45 NGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQH 104
NG W + C P E +A QA D V+ AR A+K W+ P R +
Sbjct: 56 NGSWGGRGEVITTYC--PANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEI 113
Query: 105 LTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA----------IQAS 154
+ ++ + +++ ++L +L SL G+ + E G+VQ + Y + +
Sbjct: 114 VRQIGDALREKIQVLGSLVSLEMGKILVE-GVGEVQEYVDICDYAVGLSRMIGGPILPSE 172
Query: 155 TQEEALAG-WEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVAL---VPPASPAPLLL 210
AL W P+G++G+I F W A+A+ C V L P S + +
Sbjct: 173 RSGHALIEQWNPVGLVGIITAFNFPVAVYGWN--NAIAMICGNVCLWKGAPTTSLISVAV 230
Query: 211 AQLAGEL---GPFPG-ILNVLSGPASLVPILASQPGIRKVAFCGAPEGG--LRLLIQ--- 261
++ ++ PG I ++ G A + +A + ++F G+ + G + L++Q
Sbjct: 231 TKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERF 290
Query: 262 -------------------------------------------------ESVWDEAMRRL 272
ES+ DE + RL
Sbjct: 291 GRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRL 350
Query: 273 QERMGRLRSGRGLDGAVDMG-ARGAAACDLVQRFVREAQSQGAQVFQAGDVPSERP--FY 329
++ ++R G D V G A + V EA+ +G V G V +RP +
Sbjct: 351 KKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKV-MDRPGNYV 409
Query: 330 PPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALE 389
PT+V+ L + A E P++ F+ +E N +G S+S++++ LG+
Sbjct: 410 EPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFR 469
Query: 390 -LG-YGLQVGTVWINAHGLRDPSVPT---------GGCKESGCSWHGGPDGLYEYLRPS 437
LG G G V +N +PT GG K +G G D +Y+R S
Sbjct: 470 WLGPKGSDCGIVNVN--------IPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRS 520
>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 50.1 bits (118), Expect = 8e-06
Identities = 50/192 (26%), Positives = 81/192 (42%), Gaps = 14/192 (7%)
Query: 537 RAALLWALAAALERRKSTL---------ASRLERQGAELKAAEAEVELSARRLRAWGARV 587
RAA L L L+ K L S E + +E+ ++ EV L+ R LRAW +
Sbjct: 26 RAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEVAISQGEVTLALRNLRAW---M 82
Query: 588 QAQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAA 647
+ + +A +EP G++ ++ P +PL + L ALA GN VV+ PS
Sbjct: 83 KDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEI 142
Query: 648 CPLLALEVCQDMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWAS 707
+ + + + VV G + L D +++ GS + + V A+
Sbjct: 143 SKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDY--IFFTGSPRVGKIVMTAA 200
Query: 708 AGNLKPVWASRG 719
A +L PV G
Sbjct: 201 AKHLTPVTLELG 212
>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 50.1 bits (118), Expect = 8e-06
Identities = 50/192 (26%), Positives = 81/192 (42%), Gaps = 14/192 (7%)
Query: 537 RAALLWALAAALERRKSTL---------ASRLERQGAELKAAEAEVELSARRLRAWGARV 587
RAA L L L+ K L S E + +E+ ++ EV L+ R LRAW +
Sbjct: 26 RAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEVAISQGEVTLALRNLRAW---M 82
Query: 588 QAQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAA 647
+ + +A +EP G++ ++ P +PL + L ALA GN VV+ PS
Sbjct: 83 KDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEI 142
Query: 648 CPLLALEVCQDMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWAS 707
+ + + + VV G + L D +++ GS + + V A+
Sbjct: 143 SKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDY--IFFTGSPRVGKIVMTAA 200
Query: 708 AGNLKPVWASRG 719
A +L PV G
Sbjct: 201 AKHLTPVTLELG 212
>gi|57222568 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 6 [Homo sapiens]
Length = 1093
Score = 40.8 bits (94), Expect = 0.005
Identities = 56/212 (26%), Positives = 83/212 (39%), Gaps = 25/212 (11%)
Query: 460 PSTLPAGPEIGPSPAPPYGLFVGGRFQAPGARSSRPIRDSSGNLHGYVAEGG--AKDIRG 517
P+TLP P+P PP G +APGA + + G L G GG + G
Sbjct: 844 PATLPLALPGAPAPLPPQP--QNGLGRAPGAAGLGAMPMAEGLLGGLAGSGGLPLNGLLG 901
Query: 518 AVEAAHQAFPGWAGQSPGARAALLWALAAALERRKSTLASRLERQGAELKAAEAEVELSA 577
+ A P Q+ GA L +L ++ L + E+Q +L+ A +L+
Sbjct: 902 GLNGAAAPNPASLSQAGGAPTLQLPGCLNSLTEQQRHLLQQQEQQLQQLQQLLASPQLTP 961
Query: 578 RRLRAWGARVQ--AQGHTLQ---------------VAGLRGPVLRLREPLGVLAVVCPDE 620
+Q Q LQ +AG P+L P G+L
Sbjct: 962 EHQTVVYQMIQQIQQKRELQRLQMAGGSQLPMASLLAGSSTPLLSAGTP-GLLPTASAP- 1019
Query: 621 WPLLAFVSLLAPALAYGNTVVMVPSAACPLLA 652
PLL +L+AP+L NT +M +AA +A
Sbjct: 1020 -PLLPAGALVAPSLG-NNTSLMAAAAAAAAVA 1049
>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
Length = 485
Score = 38.1 bits (87), Expect = 0.030
Identities = 29/112 (25%), Positives = 50/112 (44%), Gaps = 2/112 (1%)
Query: 608 EPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFPAGL 667
+PLGV+ ++ +P + + L A+A GN V++ PS A + + + L
Sbjct: 100 QPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDL 159
Query: 668 ANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRG 719
V+ G + T L Q ++Y G+ + V A+A +L PV G
Sbjct: 160 YIVINGGVEETTE--LLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELG 209
>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
Length = 508
Score = 38.1 bits (87), Expect = 0.030
Identities = 29/112 (25%), Positives = 50/112 (44%), Gaps = 2/112 (1%)
Query: 608 EPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFPAGL 667
+PLGV+ ++ +P + + L A+A GN V++ PS A + + + L
Sbjct: 100 QPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDL 159
Query: 668 ANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRG 719
V+ G + T L Q ++Y G+ + V A+A +L PV G
Sbjct: 160 YIVINGGVEETTE--LLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELG 209
>gi|145309315 G protein-coupled receptor 62 [Homo sapiens]
Length = 368
Score = 38.1 bits (87), Expect = 0.030
Identities = 61/231 (26%), Positives = 87/231 (37%), Gaps = 14/231 (6%)
Query: 174 PPTFSFLEMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPFPGILNVLSGPASL 233
PP L +W L +++ P PAP + LAG LGPF + +L+
Sbjct: 127 PPPVLVLTAVWAAAGLLGA-LSLLGTPPAPPPAPARCSVLAGGLGPFRPLWALLAFALPA 185
Query: 234 VPILASQPGIRKVAFCGA-----PEGGLRLLIQESVWDEAMRRLQERMGRLRSGR-GLDG 287
+ +L + GI VA A P G RL D + L RL G+ L
Sbjct: 186 LLLLGAYGGIFVVARRAALRPPRPARGSRL--HSDSLDSRLSILPPLRPRLPGGKAALAP 243
Query: 288 AVDMGARGAA----ACDLVQRFVREAQSQGAQVFQAGDVPSERPFYPPTLVSNLPPA-SP 342
A+ +G A C + R A+++ A + A + PF L + A
Sbjct: 244 ALAVGQFAACWLPYGCACLAPAARAAEAEAAVTWVAYSAFAAHPFLYGLLQRPVRLALGR 303
Query: 343 CAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALELGYG 393
++ +P PV +P ALL P G A SE Q EL G
Sbjct: 304 LSRRALPGPVRACTPQAWHPRALLQCLQRPPEGPAVGPSEAPEQTPELAGG 354
>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 37.7 bits (86), Expect = 0.039
Identities = 34/116 (29%), Positives = 52/116 (44%), Gaps = 10/116 (8%)
Query: 608 EPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFP--- 664
EPLGV+ V+ +P + + A+A GN+VV+ PS L+ + +AT+ P
Sbjct: 103 EPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSE----LSENMASLLATIIPQYL 158
Query: 665 -AGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRG 719
L V+ G T L D + Y GS + + A+A +L PV G
Sbjct: 159 DKDLYPVINGGVPETTELLKERFD--HILYTGSTGVGKIIMTAAAKHLTPVTLELG 212
Score = 33.5 bits (75), Expect = 0.74
Identities = 30/122 (24%), Positives = 51/122 (41%), Gaps = 13/122 (10%)
Query: 312 QGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGT 371
+G +V G + + PT+++++ P SP Q E+ PV+ R+ +EA+ N
Sbjct: 299 EGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQR 358
Query: 372 PR-------GGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGC-SW 423
+ + V + + + G V I H S+P GG SG S+
Sbjct: 359 EKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLH-----SLPFGGVGNSGMGSY 413
Query: 424 HG 425
HG
Sbjct: 414 HG 415
>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 37.7 bits (86), Expect = 0.039
Identities = 34/116 (29%), Positives = 52/116 (44%), Gaps = 10/116 (8%)
Query: 608 EPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFP--- 664
EPLGV+ V+ +P + + A+A GN+VV+ PS L+ + +AT+ P
Sbjct: 103 EPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSE----LSENMASLLATIIPQYL 158
Query: 665 -AGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRG 719
L V+ G T L D + Y GS + + A+A +L PV G
Sbjct: 159 DKDLYPVINGGVPETTELLKERFD--HILYTGSTGVGKIIMTAAAKHLTPVTLELG 212
Score = 33.5 bits (75), Expect = 0.74
Identities = 30/122 (24%), Positives = 51/122 (41%), Gaps = 13/122 (10%)
Query: 312 QGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGT 371
+G +V G + + PT+++++ P SP Q E+ PV+ R+ +EA+ N
Sbjct: 299 EGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQR 358
Query: 372 PR-------GGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGC-SW 423
+ + V + + + G V I H S+P GG SG S+
Sbjct: 359 EKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLH-----SLPFGGVGNSGMGSY 413
Query: 424 HG 425
HG
Sbjct: 414 HG 415
>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 37.7 bits (86), Expect = 0.039
Identities = 34/116 (29%), Positives = 52/116 (44%), Gaps = 10/116 (8%)
Query: 608 EPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFP--- 664
EPLGV+ V+ +P + + A+A GN+VV+ PS L+ + +AT+ P
Sbjct: 103 EPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSE----LSENMASLLATIIPQYL 158
Query: 665 -AGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRG 719
L V+ G T L D + Y GS + + A+A +L PV G
Sbjct: 159 DKDLYPVINGGVPETTELLKERFD--HILYTGSTGVGKIIMTAAAKHLTPVTLELG 212
Score = 33.5 bits (75), Expect = 0.74
Identities = 30/122 (24%), Positives = 51/122 (41%), Gaps = 13/122 (10%)
Query: 312 QGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGT 371
+G +V G + + PT+++++ P SP Q E+ PV+ R+ +EA+ N
Sbjct: 299 EGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQR 358
Query: 372 PR-------GGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGC-SW 423
+ + V + + + G V I H S+P GG SG S+
Sbjct: 359 EKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLH-----SLPFGGVGNSGMGSY 413
Query: 424 HG 425
HG
Sbjct: 414 HG 415
>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
Length = 431
Score = 37.0 bits (84), Expect = 0.067
Identities = 30/113 (26%), Positives = 50/113 (44%), Gaps = 2/113 (1%)
Query: 607 REPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFPAG 666
+EP G++ ++ P +PL + L ALA GN VV+ PS + + + +
Sbjct: 65 KEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQS 124
Query: 667 LANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRG 719
VV G + L D +++ GS + + V A+A +L PV G
Sbjct: 125 CFAVVLGGPQETGQLLEHRFDY--IFFTGSPRVGKIVMTAAAKHLTPVTLELG 175
>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 35.8 bits (81), Expect = 0.15
Identities = 28/113 (24%), Positives = 49/113 (43%), Gaps = 2/113 (1%)
Query: 607 REPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFPAG 666
+EP G++ ++ P +PL + LL ALA G+ VV+ PS + + +
Sbjct: 21 KEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEVLPQYLDQS 80
Query: 667 LANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRG 719
VV G + L + +++ GS + + V A+ +L PV G
Sbjct: 81 CFAVVLGGPQETGQ--LLEHKLDYIFFTGSPRVGKIVMTAATKHLTPVTLELG 131
>gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 35.8 bits (81), Expect = 0.15
Identities = 28/113 (24%), Positives = 49/113 (43%), Gaps = 2/113 (1%)
Query: 607 REPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFPAG 666
+EP G++ ++ P +PL + LL ALA G+ VV+ PS + + +
Sbjct: 21 KEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEVLPQYLDQS 80
Query: 667 LANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRG 719
VV G + L + +++ GS + + V A+ +L PV G
Sbjct: 81 CFAVVLGGPQETGQ--LLEHKLDYIFFTGSPRVGKIVMTAATKHLTPVTLELG 131
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,733,281
Number of Sequences: 37866
Number of extensions: 1710911
Number of successful extensions: 5864
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 49
Number of HSP's that attempted gapping in prelim test: 5691
Number of HSP's gapped (non-prelim): 171
length of query: 751
length of database: 18,247,518
effective HSP length: 110
effective length of query: 641
effective length of database: 14,082,258
effective search space: 9026727378
effective search space used: 9026727378
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.