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Search of human proteins with 222537714
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222537714 taxilin beta [Homo sapiens]
(684 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222537714 taxilin beta [Homo sapiens] 1350 0.0
gi|28460688 taxilin [Homo sapiens] 483 e-136
gi|8922940 gamma-taxilin [Homo sapiens] 415 e-116
gi|14211893 lipopolysaccaride-specific response 5-like protein [... 120 3e-27
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 84 4e-16
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 79 2e-14
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 79 2e-14
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 79 2e-14
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 78 3e-14
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 77 4e-14
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 77 4e-14
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 76 1e-13
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 75 2e-13
gi|150010552 FK506 binding protein 15, 133kDa [Homo sapiens] 75 2e-13
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 74 3e-13
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 74 3e-13
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 74 6e-13
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 73 8e-13
gi|156104908 myosin heavy chain 6 [Homo sapiens] 73 1e-12
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 73 1e-12
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 72 1e-12
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 72 1e-12
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 72 1e-12
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 72 2e-12
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 71 4e-12
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 70 5e-12
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 70 6e-12
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 70 8e-12
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 70 8e-12
gi|148746195 trichohyalin [Homo sapiens] 69 1e-11
>gi|222537714 taxilin beta [Homo sapiens]
Length = 684
Score = 1350 bits (3493), Expect = 0.0
Identities = 684/684 (100%), Positives = 684/684 (100%)
Query: 1 MEANHSEQLSAERQSTPPGDSSSLPSHNGLEKEDGQDSPTPVQPPEKEASVHPDISEELN 60
MEANHSEQLSAERQSTPPGDSSSLPSHNGLEKEDGQDSPTPVQPPEKEASVHPDISEELN
Sbjct: 1 MEANHSEQLSAERQSTPPGDSSSLPSHNGLEKEDGQDSPTPVQPPEKEASVHPDISEELN 60
Query: 61 RQLEDIINTYGSAASTAGKEGSARASEQPENAESPDNEDGDCEETTEEAGREPVASGEPP 120
RQLEDIINTYGSAASTAGKEGSARASEQPENAESPDNEDGDCEETTEEAGREPVASGEPP
Sbjct: 61 RQLEDIINTYGSAASTAGKEGSARASEQPENAESPDNEDGDCEETTEEAGREPVASGEPP 120
Query: 121 TVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQ 180
TVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQ
Sbjct: 121 TVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQ 180
Query: 181 KKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEE 240
KKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEE
Sbjct: 181 KKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEE 240
Query: 241 EKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIF 300
EKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIF
Sbjct: 241 EKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIF 300
Query: 301 KHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQL 360
KHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQL
Sbjct: 301 KHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQL 360
Query: 361 TLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMI 420
TLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMI
Sbjct: 361 TLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMI 420
Query: 421 EEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEPES 480
EEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEPES
Sbjct: 421 EEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEPES 480
Query: 481 NVSVDQEIDAEEVNSVQTAVKNLATAFMIIHHPESTPHQSKETQPEIGSSQESADAALKE 540
NVSVDQEIDAEEVNSVQTAVKNLATAFMIIHHPESTPHQSKETQPEIGSSQESADAALKE
Sbjct: 481 NVSVDQEIDAEEVNSVQTAVKNLATAFMIIHHPESTPHQSKETQPEIGSSQESADAALKE 540
Query: 541 PEQPPLIPSRDSESPLPPLTPQAEAEGGSDAEPPSKASNSPAGLGAETQCEGLPVGAQAD 600
PEQPPLIPSRDSESPLPPLTPQAEAEGGSDAEPPSKASNSPAGLGAETQCEGLPVGAQAD
Sbjct: 541 PEQPPLIPSRDSESPLPPLTPQAEAEGGSDAEPPSKASNSPAGLGAETQCEGLPVGAQAD 600
Query: 601 QASWKPEAEASGQAPQAPTEASLQKMEADVPAPACAAEEHVAAMVPACEPSRQPPRAAAE 660
QASWKPEAEASGQAPQAPTEASLQKMEADVPAPACAAEEHVAAMVPACEPSRQPPRAAAE
Sbjct: 601 QASWKPEAEASGQAPQAPTEASLQKMEADVPAPACAAEEHVAAMVPACEPSRQPPRAAAE 660
Query: 661 ELPVGASAGPQPRNVADTNLEGVD 684
ELPVGASAGPQPRNVADTNLEGVD
Sbjct: 661 ELPVGASAGPQPRNVADTNLEGVD 684
>gi|28460688 taxilin [Homo sapiens]
Length = 546
Score = 483 bits (1242), Expect = e-136
Identities = 265/506 (52%), Positives = 353/506 (69%), Gaps = 32/506 (6%)
Query: 4 NHSEQLSAERQSTP---PGDSSSLPSHNGLEKEDGQ-------DSPTPVQPPEK------ 47
N ++ A +QS P PG + P G ++ Q + P Q P K
Sbjct: 3 NQDKKNGAAKQSNPKSSPGQPEAGPE--GAQERPSQAAPAVEAEGPGSSQAPRKPEGAQA 60
Query: 48 ---EASVHPDISEELNRQLEDIINTY--GSAASTAGKEGSARASEQPENAESPDN---ED 99
++ D+SEEL+RQLEDI++TY + G++G+ +PE+AE +
Sbjct: 61 RTAQSGALRDVSEELSRQLEDILSTYCVDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARN 120
Query: 100 GDCEETTEEAGREPVASGEPPTVK----EPVSNKEQKL--EKKILKGLGKEANLLMQNLN 153
G+ E T G + + G+P T + + V +++ + EKK KGLGKE LLMQ LN
Sbjct: 121 GEPEPTPVVNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLN 180
Query: 154 KLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSK 213
L TPEEK L KKYAELL+EHR QK++KLLQKKQ Q+ +EKD L+GEHS+A+LARSK
Sbjct: 181 TLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSK 240
Query: 214 LESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQ 273
LESLCRELQRHN++LKEE +QRAREEEEKRKE+TSHFQ TL DIQ Q+EQ +ERN KL Q
Sbjct: 241 LESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQ 300
Query: 274 ENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKE 333
EN ELAE+LK +I+QYELREEH+DK+FKH++LQQ+LVDAKL+QAQEM+KEAEERH+REK+
Sbjct: 301 ENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQREKD 360
Query: 334 YLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTK 393
+LL +A E + +++K+QET L+ QL LY+ +FEEFQ+TL+KS+EVF TFKQEM+K TK
Sbjct: 361 FLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKSSEVFTTFKQEMEKMTK 420
Query: 394 KMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNE 453
K+KKLEK+T +++R+E+ NKALL+M EEK +R KE E +KI RLE LCRALQ ERN+
Sbjct: 421 KIKKLEKETTMYRSRWESSNKALLEMAEEKTVRDKELEGLQVKIQRLEKLCRALQTERND 480
Query: 454 LHKKIRDAEISEKDDQSQHNSDEEPE 479
L+K+++D + + + PE
Sbjct: 481 LNKRVQDLSAGGQGSLTDSGPERRPE 506
>gi|8922940 gamma-taxilin [Homo sapiens]
Length = 528
Score = 415 bits (1066), Expect = e-116
Identities = 243/507 (47%), Positives = 322/507 (63%), Gaps = 41/507 (8%)
Query: 60 NRQLEDIINTYGSAASTAGKEGSARASEQPENAES-PDNEDGDCEETTEEAGREPVASGE 118
N Q DI+ GS G + + E+ E ++ +N + + RE + GE
Sbjct: 57 NSQSNDILQHQGS---NCGGTSNKHSLEEDEGSDFITENRNLVSPAYCTQESREEIPGGE 113
Query: 119 PPTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRT 178
T P ++ + + K LGKE LLMQ LN L TPEEK L KKYA+LL+E R+
Sbjct: 114 ART-DPPDGQQDSECNRNKEKTLGKEVLLLMQALNTLSTPEEKLAALCKKYADLLEESRS 172
Query: 179 EQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRARE 238
QK++K+LQKKQ QI KEK LQ EHS+AILARSKLESLCRELQRHNKTLKEE +Q+ARE
Sbjct: 173 VQKQMKILQKKQAQIVKEKVHLQSEHSKAILARSKLESLCRELQRHNKTLKEENMQQARE 232
Query: 239 EEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDK 298
EEE+RKE T+HFQ TL +IQ Q+EQ N KL QEN EL EKLK +I+QY LREEH+DK
Sbjct: 233 EEERRKEATAHFQITLDEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDK 292
Query: 299 IFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQA 358
+FK +ELQQ+LVDAKL+Q +++KEA+E+H+RE+E+LL +A E + + + +K+QE L+
Sbjct: 293 VFKRKELQQQLVDAKLQQTTQLIKEADEKHQREREFLLKEATESRHKYEQMKQQEVQLKQ 352
Query: 359 QLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLD 418
QL+LY +FEEFQ+T+ KSNE+F TF+QEM+K TKK+KKLEK+T W+ ++EN NKALL
Sbjct: 353 QLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIIWRTKWENNNKALLQ 412
Query: 419 MIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEP 478
M EEK +R KEY+ +K+ RLE LCRALQ ERNEL++K+ E
Sbjct: 413 MAEEKTVRDKEYKALQIKLERLEKLCRALQTERNELNEKV-----------------EVL 455
Query: 479 ESNVSVDQEIDAEEVNSVQTAVKNLATAFMIIHHPESTPHQSKETQPEIGSSQESADAAL 538
+ VS+ I A A ++LAT P P + ++ E+ +S + A A
Sbjct: 456 KEQVSIKAAIKA--------ANRDLAT-------PVMQPCTALDSHKELNTSSKRALGAH 500
Query: 539 KEPEQPPLIPSRDSESPLPPLTPQAEA 565
E E S+ S PP T A A
Sbjct: 501 LEAEP----KSQRSAVQKPPSTGSAPA 523
>gi|14211893 lipopolysaccaride-specific response 5-like protein
[Homo sapiens]
Length = 181
Score = 120 bits (302), Expect = 3e-27
Identities = 71/174 (40%), Positives = 100/174 (57%), Gaps = 17/174 (9%)
Query: 349 LKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKAR 408
+K++E L+ QL LY +FEEFQ+T+ K+NE+F FKQE +K TKK+KKLEK+ W +
Sbjct: 1 MKQEEAQLKEQLFLYMDKFEEFQTTMAKTNELFTAFKQETEKLTKKIKKLEKEMVIWYTK 60
Query: 409 FENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHK-----------K 457
+EN N LL M EEK +R K Y+ F +K+ RLE L +ALQ ERNEL + K
Sbjct: 61 WENNNTTLLQMAEEKTIRDKNYKVFQIKLERLEKLYKALQIERNELSEKLGILKGQVSVK 120
Query: 458 IRDAEISEKDDQSQHNSDEEPESNVS------VDQEIDAEEVNSVQTAVKNLAT 505
+ D +++ S + D N S V E D + +N V+ K L+T
Sbjct: 121 VADVDLAVPVTHSCADLDSSNMLNTSSKRAPGVHLEADPKGMNEVKCYSKALST 174
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 84.0 bits (206), Expect = 4e-16
Identities = 93/373 (24%), Positives = 178/373 (47%), Gaps = 33/373 (8%)
Query: 98 EDGDCEETTEEAGREPVA---SGEPPTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNK 154
EDG+ E+ + AGR + +GE VS +K ++ I + L KE + L L +
Sbjct: 119 EDGNLGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYI-EELTKERDALSLELYR 177
Query: 155 LQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRA--ILARS 212
E+ L KK AEL Q+KL+L + ++ +IQ +L+ + RA +L +
Sbjct: 178 NTITNEE---LKKKNAEL-------QEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQV 227
Query: 213 KLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLC 272
+ +L E+ R + L+E+ ++ R++EEK + ++ Q E+ + +L
Sbjct: 228 QTNTLQEEMWRQEEELREQE-KKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLR 286
Query: 273 QENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERHKREK 332
++ EL E+ K + +Q +LRE+ E Q + + K+ + +E M+E EE+ R++
Sbjct: 287 EQEKELREQEKELREQKKLREQ---------EEQMQEQEEKMWEQEEKMREQEEKMWRQE 337
Query: 333 EYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFK--QEMDK 390
E L Q + + Q + +++QE + Q R E + + + +++ + QE ++
Sbjct: 338 ERLWEQEKQMREQEQKMRDQEERMWEQ----DERLREKEERMREQEKMWEQEEKMQEEER 393
Query: 391 TTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEE 450
++ KK+ ++ T + + E K +M E++ ++ K E QEE
Sbjct: 394 IREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEE 453
Query: 451 RN-ELHKKIRDAE 462
+ E +KIRD E
Sbjct: 454 KIWEQEEKIRDQE 466
Score = 64.7 bits (156), Expect = 3e-10
Identities = 99/457 (21%), Positives = 202/457 (44%), Gaps = 55/457 (12%)
Query: 57 EELNRQLEDIINTYGSAASTAGKEGSARASEQPENAESPDNEDGDCEETTEEAGREPVAS 116
+EL R+LE + +E R E+ E + + EE RE
Sbjct: 211 KELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQ--E 268
Query: 117 GEPPTVKEPVSNKEQKL--EKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLD 174
G+ +E + +E++L ++K L+ KE ++ KL+ EE+ +K E +
Sbjct: 269 GKMREQEEKMRRQEKRLREQEKELREQEKE----LREQKKLREQEEQMQEQEEKMWEQEE 324
Query: 175 EHRTEQKKLKLL------QKKQV--QIQKEKDQLQGEHSRAILARSKLESLCRELQRHNK 226
+ R +++K+ Q+KQ+ Q QK +DQ + + R K E + + + +
Sbjct: 325 KMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQ 384
Query: 227 TLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSII 286
K + +R RE E+K +E + +Q Q E E+ K Q+ L E+ + +
Sbjct: 385 EEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ-RLPEQKEKLW 443
Query: 287 DQYELREEHLDKIF----KHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAE- 341
+Q +++E+ +KI+ K R+ ++ K QE M+E E++ ++E + +Q +
Sbjct: 444 EQEKMQEQE-EKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKM 502
Query: 342 WKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKD 401
W + ++ ++ E R E + + + +++ Q+ +K ++ K E++
Sbjct: 503 WDQEERMWEQDE------------RLREKEERMREQKKMW----QQEEKMREEKKTQEQE 546
Query: 402 TATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDA 461
TW + M EE+ +R +E K+ E + R +E+ E +K+R+
Sbjct: 547 KKTWDQEEK--------MREEERMRERE-----KKMREEEEMMREQEEKMQEQEEKMREQ 593
Query: 462 EISEKDDQSQHNSDEEPESNVSVDQEI-DAEEVNSVQ 497
E EK + + E+ E ++++ + EE + +Q
Sbjct: 594 E--EKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQ 628
Score = 61.6 bits (148), Expect = 2e-09
Identities = 68/361 (18%), Positives = 165/361 (45%), Gaps = 17/361 (4%)
Query: 79 KEGSARASEQPENAESPDNEDGDCEETTEEAGREPVASGEPPTVKEPVSNKE--QKLEKK 136
+E + E+ E + + EE E + P KE + +E Q+ E+K
Sbjct: 395 REREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEK 454
Query: 137 ILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKK---QVQI 193
I + K +++ ++ E+K + +K E D+ +++K++ ++K Q +
Sbjct: 455 IWEQEEK-----IRDQEEMWGQEKKM-WRQEKMREQEDQMWEQEEKMRDQEQKMWDQEER 508
Query: 194 QKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQST 253
E+D+ E + + K+ +++ KT ++E +EE+ + +E +
Sbjct: 509 MWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKK 568
Query: 254 LTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRE-LQQKLVDA 312
+ + + + +Q E K+ ++ ++ E+ + + +Q E +E +K+++ E + ++ +
Sbjct: 569 MREEEEMMREQEE---KMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEED 625
Query: 313 KLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQS 372
K+++ +EMM E EE+ + ++E + Q + + Q + ++EQE +Q Q + E+ Q
Sbjct: 626 KMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQG 685
Query: 373 TLTKSNEVFATFKQEMDKTTKKMKKL--EKDTATWKARFENCNKALLDMIEEKALRAKEY 430
K E + + +K + +K+ +++ + + + D E+ R E+
Sbjct: 686 QEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEH 745
Query: 431 E 431
E
Sbjct: 746 E 746
Score = 58.9 bits (141), Expect = 1e-08
Identities = 76/399 (19%), Positives = 174/399 (43%), Gaps = 54/399 (13%)
Query: 84 RASEQPENAESPDNEDGDCEETTEEAGREPVASGEPPTVKEPVSNKEQKLEKKIL----- 138
R EQ + + + D EE E E +E + +E+K++++
Sbjct: 339 RLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRERE 398
Query: 139 KGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKD 198
K + +E + + K+Q EE ++++ + + R ++K KL +++++Q Q+EK
Sbjct: 399 KKMREEEETMREQEEKMQKQEEN---MWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI 455
Query: 199 QLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQ 258
Q E R + ++ +++ R K ++E + E+EEK ++
Sbjct: 456 WEQEEKIRD---QEEMWGQEKKMWRQEKMREQE--DQMWEQEEKMRD------------- 497
Query: 259 GQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQAQ 318
Q ++ ++ ++ +++ L EK EE + + K + ++K+ + K Q Q
Sbjct: 498 -QEQKMWDQEERMWEQDERLREK-----------EERMREQKKMWQQEEKMREEKKTQEQ 545
Query: 319 EMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSN 378
E +E RE+E + + + + + ++++EQE +Q Q + + +
Sbjct: 546 EKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQ-----------EEKMREQE 594
Query: 379 EVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIG 438
E +++M + +KM E++ W+ E+ + +M+ E+ + +E E K+
Sbjct: 595 EKMWEQEEKMQEQEEKM--WEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQE---EKMW 649
Query: 439 RLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEE 477
E R +E+ E +K++ E ++ + + EE
Sbjct: 650 EQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEE 688
Score = 46.2 bits (108), Expect = 1e-04
Identities = 42/221 (19%), Positives = 104/221 (47%), Gaps = 5/221 (2%)
Query: 149 MQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAI 208
M+ K Q E+K + + ++ +E R +++ K+ +++++ ++E+ + E
Sbjct: 536 MREEKKTQEQEKK---TWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMRE 592
Query: 209 LARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERN 268
E + ++ K ++E +EEE+K +E +Q Q E+ E+
Sbjct: 593 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQE 652
Query: 269 MKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERH 328
K+ ++ ++ E+ + + Q E E +K+ + +E + + + K+ +E M EE+
Sbjct: 653 EKMREQEEKMREQEEKMQGQEEKMREQEEKM-QGQEEKMREQEEKMRGQEEKMWGQEEKM 711
Query: 329 KREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEE 369
++E + Q E + + + +++Q+ +Q +L + R E
Sbjct: 712 WGQEEKMWGQ-EEMREKEERIRDQKEKMQERLPEHEERCSE 751
Score = 45.8 bits (107), Expect = 1e-04
Identities = 66/315 (20%), Positives = 136/315 (43%), Gaps = 40/315 (12%)
Query: 220 ELQRHNKTLK--EEALQRAREEEEKRKEITSH--FQSTLTDIQGQIEQQSERNMKLCQEN 275
ELQR + + R EE K ++ S +++T+T+ E+ ++N +L QE
Sbjct: 142 ELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITN-----EELKKKNAEL-QEK 195
Query: 276 TELAEKLKSII--DQYELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKE 333
LAE KS I + EL+ + F ++Q + ++ + +E ++E E++ ++++E
Sbjct: 196 LRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 255
Query: 334 YLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTK 393
+ Q + Q ++EQE ++ Q R E + L +E +K +
Sbjct: 256 KMWRQEERLREQEGKMREQEEKMRRQ----EKRLREQEKEL-----------REQEKELR 300
Query: 394 KMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNE 453
+ KKL + + + E + +E+ +R +E K+ R E +++ E
Sbjct: 301 EQKKLREQEEQMQEQEEKMWE------QEEKMREQE-----EKMWRQEERLWEQEKQMRE 349
Query: 454 LHKKIRDAE--ISEKDDQSQHNSDEEPESNVSVDQEIDAEEVNSVQTAVKNLATAFMIIH 511
+K+RD E + E+D++ + + E +QE +E ++ K + +
Sbjct: 350 QEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMR 409
Query: 512 HPESTPHQSKETQPE 526
E + +E E
Sbjct: 410 EQEEKMQKQEENMWE 424
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 78.6 bits (192), Expect = 2e-14
Identities = 97/451 (21%), Positives = 205/451 (45%), Gaps = 50/451 (11%)
Query: 121 TVKEPVSNKEQKLEKKILKG----LGKEANLLMQNLN-KLQTPEEKFDFLFKKYAELLDE 175
++K+ ++ +E+ EK+ILK L +E + + LN ++QT + + + L+ E
Sbjct: 797 SIKQKLTKQEE--EKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTE 854
Query: 176 HRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQR 235
T + KL K ++ K + + E+ + A LE C+EL+ + E L+
Sbjct: 855 LSTVKDKLS---KVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKE 911
Query: 236 AREEE---EKRKEITSHFQSTLTDIQGQI-------------EQQSERNMKLCQENTELA 279
+E + EK KE + + L +Q Q+ EQQ + N+ ++++E
Sbjct: 912 QKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQK 971
Query: 280 EKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQA 339
+K + Q EL+ L K +LQQ+L A AQE+ E E+ + Y +Q
Sbjct: 972 KKQIEAL-QGELKIAVLQKTELENKLQQQLTQA----AQELAAEKEKISVLQNNYEKSQE 1026
Query: 340 AEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKL- 398
+LQ+ + +L + L S + L+ + E + + ++ K +++L
Sbjct: 1027 TFKQLQSDFYGRESELLATRQDLKS-----VEEKLSLAQEDLISNRNQIGNQNKLIQELK 1081
Query: 399 ------EKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERN 452
E+D+A + + + KAL D+ +EK+L+ KE K+ +E + ++E
Sbjct: 1082 TAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEIT 1141
Query: 453 ELHKKIRDAEISEKDDQSQHNSDEEPESNVSVDQEIDAE-EVNSVQTAVKNLATAFMIIH 511
+L+++++ S K + + ++ + + + Q+++ + + +S++ AV+ I+
Sbjct: 1142 KLNEELK----SHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQIL- 1196
Query: 512 HPESTPHQSKETQPEIGSSQESADAALKEPE 542
+ + +E + E + + +KE E
Sbjct: 1197 -KDQVKKEEEELKKEFIEKEAKLHSEIKEKE 1226
Score = 65.5 bits (158), Expect = 2e-10
Identities = 122/601 (20%), Positives = 242/601 (40%), Gaps = 82/601 (13%)
Query: 24 LPSHNGLE----KEDGQDSPTPVQPPEKEASVHPDISEELN-RQLEDIINTYGSAASTAG 78
L + GL+ K DG + + + E + +E N +Q++D+ + +T
Sbjct: 113 LEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEI 172
Query: 79 KEGSARASEQPENAESPDNEDGDCEETTEEAGREPVASGEPPTVKEPVSNKEQKLEKKIL 138
+ ++ E+ E+ + + TEE +E Q L+ ++L
Sbjct: 173 ADIKSKYDEERSLREAAEQK---VTRLTEELNKEATVI--------------QDLKTELL 215
Query: 139 KGLG-KEANLLMQNLNKLQTPEEKFDFLFKKYAELL-DEHRTEQKKLKLLQKKQVQIQKE 196
+ G ++ +L + L ++QT + ++ +E L DE + Q + + Q++ E
Sbjct: 216 QRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSE 275
Query: 197 KDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRARE----EEEKRKEITS--HF 250
+ E + + KL+S EL + N+TL E L++ ++ EE+ +E S +
Sbjct: 276 LAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNI 335
Query: 251 QSTLTDIQGQIEQQSER-----------NMKLCQENTELAEKLKSIIDQYELREEHLDKI 299
Q+TL +Q R +++L E E +KLK + + E + +HL
Sbjct: 336 QATLHQKDLDCQQLQSRLSASETSLHRIHVEL-SEKGEATQKLKEELSEVETKYQHLKAE 394
Query: 300 FKHRELQQK--------------LVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQ 345
FK + Q++ + +KL + + + EA R K +++ + + + Q
Sbjct: 395 FKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQ 454
Query: 346 AKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKD---- 401
L+ + + L+ QL E Q L K+ + + TT K+++ + D
Sbjct: 455 VADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQV 514
Query: 402 ---TATWKARFENCNKALLDMIEEKALRAKEYECFVMKI----------GRLENLCRALQ 448
+ +N L E +L KE E KI +L+ LQ
Sbjct: 515 LRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQ 574
Query: 449 EERNELHKKIRDAEISEKDDQSQ-HNSDEEPESNVSVDQEIDAEEVNSVQTAVKNLATAF 507
E+ +L +K+++ S K Q H+ +E ++++ Q + V S++T+V L +
Sbjct: 575 EQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQ----DRVLSLETSVNELNSQL 630
Query: 508 MIIHHPESTPHQSKETQPEIGSSQESADAALKEPEQPPLIPS----RDSESPLPPLTPQA 563
S + + E+ S E+A A + Q L + +D + L +T Q
Sbjct: 631 NESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQL 690
Query: 564 E 564
+
Sbjct: 691 D 691
Score = 65.5 bits (158), Expect = 2e-10
Identities = 90/413 (21%), Positives = 193/413 (46%), Gaps = 41/413 (9%)
Query: 128 NKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQ 187
+K + E+++ + G+ + KL E++ L K + L EQ K K+
Sbjct: 421 SKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRL-----EEQLKEKVTN 475
Query: 188 KKQVQIQKEKDQLQGEHSRAIL---------ARSKLESLCRELQRHNKTLK--EEALQRA 236
++Q Q +K + Q + +A+ A++ LE + R++ ++ ++ E LQ++
Sbjct: 476 STELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKS 535
Query: 237 REE----EEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELR 292
+E E++R+++ + Q+ + + Q E+N L ++ T+L EKLK+ + ++
Sbjct: 536 KENISLLEKEREDLYAKIQAGEGET-AVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQA 594
Query: 293 EEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAE--WKLQAKVLK 350
+E+L H ++Q++ A L AQ+ + E E LN++ E +L ++
Sbjct: 595 QENL-----HDQVQEQ--KAHLRAAQDRVLSL-ETSVNELNSQLNESKEKVSQLDIQIKA 646
Query: 351 EQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFE 410
+ E +L A+ + R + Q+ L + +QE++K T +L++ TA + + E
Sbjct: 647 KTELLLSAEAAKTAQR-ADLQNHLDTAQNALQDKQQELNKIT---TQLDQVTAKLQDKQE 702
Query: 411 NCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQS 470
+C++ + E K ++Y K LE + L+ + E+ K ++ + + Q
Sbjct: 703 HCSQLESHLKEYK----EKYLSLEQKTEELEGQIKKLEADSLEV-KASKEQALQDLQQQR 757
Query: 471 QHNSD-EEPESNVSVDQEIDAEEVNSVQTAVKNLATAFMIIHHPESTPHQSKE 522
Q N+D E + +S E++ E V+S + ++ + A I + + K+
Sbjct: 758 QLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQ 810
Score = 58.5 bits (140), Expect = 2e-08
Identities = 88/376 (23%), Positives = 167/376 (44%), Gaps = 66/376 (17%)
Query: 127 SNKEQKLEKKILKGLGKEANLLMQNL-NKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKL 185
S++++K + + L+G K A L L NKLQ ++ + E E++K+ +
Sbjct: 967 SSEQKKKQIEALQGELKIAVLQKTELENKLQ----------QQLTQAAQELAAEKEKISV 1016
Query: 186 LQKKQVQIQKEKDQLQ----GEHSRAILARSKLESLCRELQ--------------RHNKT 227
LQ + Q+ QLQ G S + R L+S+ +L NK
Sbjct: 1017 LQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKL 1076
Query: 228 LKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAE------- 280
++E +A E++ K+ Q +Q +++S + +L E ++LAE
Sbjct: 1077 IQELKTAKATLEQDSAKK-EQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCR 1135
Query: 281 ------KLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQA--QEMMKEAEERHKREK 332
KL + ++L E + +I ++ +Q L+ KLE + +K A E+ KR +
Sbjct: 1136 QEKEITKLNEELKSHKL--ESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQ 1193
Query: 333 EYLLNQAAEWKLQAKV-LKEQETVLQAQLT---LYSGRFEEFQSTLTKS----NEVFATF 384
+ L +Q + + + K E+E L +++ + + EE ++ LT NE T
Sbjct: 1194 QILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTV 1253
Query: 385 KQEMDKTTKKMKKLEKDT-------ATWKARFENC---NKALLDMIEEKALRAKEYECFV 434
K+E + +++ +LEK T A +A +N +ALL+ + ++ + V
Sbjct: 1254 KKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKV 1313
Query: 435 MKIGR-LENLCRALQE 449
+++ R L+N A+QE
Sbjct: 1314 LELQRKLDNTTAAVQE 1329
Score = 51.6 bits (122), Expect = 2e-06
Identities = 90/437 (20%), Positives = 176/437 (40%), Gaps = 42/437 (9%)
Query: 141 LGKEANLLMQNLNKLQTPEEKFDFLFKKYAELL---DEHRTEQKK---------LKLLQK 188
L N L LN+ + + D K ELL + +T Q+ LQ
Sbjct: 619 LETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQD 678
Query: 189 KQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITS 248
KQ ++ K QL ++ + K E C +L+ H K KE+ L ++ EE +I
Sbjct: 679 KQQELNKITTQLDQVTAKL---QDKQEH-CSQLESHLKEYKEKYLSLEQKTEELEGQIKK 734
Query: 249 HFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREE-----HLDKIFKHR 303
++ +++ EQ + + Q NT+L + + Q E+ +E LD K
Sbjct: 735 -LEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSE 793
Query: 304 ELQ---QKLVDAKLEQAQEMMKE----AEERHKREKEYLLNQAAEWKLQAKVLKEQETVL 356
L+ QKL K E+ ++++K+ + K + E L N+ + + +K ++ L
Sbjct: 794 ALESIKQKLT--KQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEAL 851
Query: 357 QAQLTLYSGRFEEFQSTLTKSNEVFATFKQ-------EMDKTTKKMK-KLEKDTATWKAR 408
+L+ + + +L S F Q +++KT K++K +L+
Sbjct: 852 MTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKE 911
Query: 409 FENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDD 468
+ K+L E E ++ + +N + ++E +L I + + S +
Sbjct: 912 QKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQK 971
Query: 469 QSQHNSDEEPESNVSVDQEIDAEE--VNSVQTAVKNLATAFMIIHHPESTPHQSKETQPE 526
+ Q + + E ++V Q+ + E + A + LA I ++ +S+ET +
Sbjct: 972 KKQIEA-LQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQ 1030
Query: 527 IGSSQESADAALKEPEQ 543
+ S ++ L Q
Sbjct: 1031 LQSDFYGRESELLATRQ 1047
Score = 47.4 bits (111), Expect = 4e-05
Identities = 74/328 (22%), Positives = 122/328 (37%), Gaps = 59/328 (17%)
Query: 198 DQLQGEHSRAILARSKLESLCRELQRHNKTLKEEA------------LQRAREEEEKRKE 245
D G S L R + L +E+Q +LKEE Q +++E K
Sbjct: 69 DSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDG 128
Query: 246 ITSHFQSTLTDIQGQIEQQSERNM-----------KLCQENTELAEKLKSIIDQYELREE 294
+ + + L ++ Q+E+ N K Q TE+A+ ++ LRE
Sbjct: 129 LVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREA 188
Query: 295 HLDKIFKHRELQQK----LVDAKLEQAQEMMKEAEERHKRE----KEYLLNQAAEWKLQA 346
K+ + E K + D K E Q E K+E + + N E + ++
Sbjct: 189 AEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERES 248
Query: 347 KVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWK 406
+ LK++ LQ+Q + +S L K + A + QE+ K + +L + T
Sbjct: 249 EKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLT 308
Query: 407 ARFENCNKALLD--MIEEK-------------ALRAKEYECFVMKIGRLENLCRALQEER 451
EN K D +EEK L K+ +C + L L
Sbjct: 309 ---ENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDC--------QQLQSRLSASE 357
Query: 452 NELHKKIRDAEISEKDDQSQHNSDEEPE 479
LH+ E+SEK + +Q +E E
Sbjct: 358 TSLHR--IHVELSEKGEATQKLKEELSE 383
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 78.6 bits (192), Expect = 2e-14
Identities = 123/590 (20%), Positives = 236/590 (40%), Gaps = 88/590 (14%)
Query: 83 ARASEQPENAESPDNEDGDCEETTEEAGREPVASGEPPTVKE------PVSNKEQKLEKK 136
A+ E E AE D E+ + E T ++ E S + + V ++ E K
Sbjct: 923 AKIKEVTERAE--DEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 980
Query: 137 ILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKE 196
+ K L +E L + + KL T E+K L + + + LD+ + E+ K+ L K +++++++
Sbjct: 981 V-KNLTEEMAGLDETIAKL-TKEKKA--LQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQ 1036
Query: 197 KDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTD 256
D L+G + R LE R+L+ K L +E++ E+++ E + +++
Sbjct: 1037 VDDLEGSLEQEKKLRMDLERAKRKLEGDLK-LAQESIMDIENEKQQLDEKLKKKEFEISN 1095
Query: 257 IQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQ 316
+Q +IE + ++L ++ EL +++ + ++ E K E Q+ + +LE+
Sbjct: 1096 LQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAK----AEKQRSDLSRELEE 1151
Query: 317 AQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTK 376
E ++EA + E + AE++ + L +E LQ + T +TL K
Sbjct: 1152 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDL--EEATLQHEAT---------AATLRK 1200
Query: 377 SN-EVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVM 435
+ + A +++D + +KLEK+ + K ++ A E
Sbjct: 1201 KHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL--------------ASNVETVSK 1246
Query: 436 KIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEPESNVSVDQEIDAEEVNS 495
G LE +CR L+++ +EL K E++ Q N + + + +++
Sbjct: 1247 AKGNLEKMCRTLEDQLSELKSK-------EEEQQRLINDLTAQRGRLQTESGEFSRQLDE 1299
Query: 496 VQTAVKNLATAFMIIHHPESTPHQSKETQPEIGSSQESADAALKEPEQPPLIPSRDSESP 555
+ V L+ + ++ + EI + A A + S
Sbjct: 1300 KEALVSQLSRGKQAF--TQQIEELKRQLEEEIKAKNALAHAL------------QSSRHD 1345
Query: 556 LPPLTPQAEAEGGSDAEPPSKASNSPAGLGAETQCEGLPVGAQADQASWKPEAEASGQAP 615
L Q E E S AE S A + A W+ + E
Sbjct: 1346 CDLLREQYEEEQESKAELQRALSK-----------------ANTEVAQWRTKYETDAIQR 1388
Query: 616 QAPTEASLQKMEADVPAPACAAEEHVAAMVPAC---EPSRQPPRAAAEEL 662
E + +K+ + AAEEHV A+ C E ++Q + E+L
Sbjct: 1389 TEELEEAKKKLAQRLQ----AAEEHVEAVNAKCASLEKTKQRLQNEVEDL 1434
Score = 58.2 bits (139), Expect = 3e-08
Identities = 78/389 (20%), Positives = 168/389 (43%), Gaps = 28/389 (7%)
Query: 127 SNKEQKLEKKILKGLGKEA----NLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKK 182
++ E + +K + LG E N ++L++L+T + + L ++ ++L ++ K+
Sbjct: 1469 THAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKR 1528
Query: 183 LKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEK 242
+ L+K + Q+++EK +LQ A + E +Q +K E ++ E++E+
Sbjct: 1529 IHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEE 1588
Query: 243 RKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKH 302
++ + + +Q ++ + ++ + L +K++ +++ E++ H +++
Sbjct: 1589 IDQLKRNHIRIVESMQSTLDAE----IRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAE 1644
Query: 303 RELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQL-- 360
+ L+ Q + +A R +E L Q A + +A +L+ + L+A L
Sbjct: 1645 ALRNYRNTQGILKDTQIHLDDA----LRSQEDLKEQLAMVERRANLLQAEIEELRATLEQ 1700
Query: 361 TLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFE-------NCN 413
T S + E Q L S V Q K KKLE D + + E N
Sbjct: 1701 TERSRKIAE-QELLDASERVQLLHTQNTSLINTK-KKLETDISQMQGEMEDILQEARNAE 1758
Query: 414 KALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEI-----SEKDD 468
+ I + A+ A+E + LE + + +++ +L ++ +AE +K
Sbjct: 1759 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQI 1818
Query: 469 QSQHNSDEEPESNVSVDQEIDAEEVNSVQ 497
Q E E V +Q+ +AE V ++
Sbjct: 1819 QKLEARVRELEGEVESEQKRNAEAVKGLR 1847
Score = 57.0 bits (136), Expect = 6e-08
Identities = 102/448 (22%), Positives = 177/448 (39%), Gaps = 76/448 (16%)
Query: 80 EGSARASEQPENAESPDNEDGDCEETTEEAGREPVASGEPPTVKEPVSNKEQK-LEKKIL 138
E ++RA + + ++ E + E EEAG A E +E K ++ LE+ L
Sbjct: 1131 ERASRAKAEKQRSDL-SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL 1189
Query: 139 KGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKD 198
+ A L ++ + + E+ D L R +QK L+K++ +++ E D
Sbjct: 1190 QHEATAATLRKKHADSVAELGEQIDNL----------QRVKQK----LEKEKSEMKMEID 1235
Query: 199 QLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKR--KEITSH------- 249
L A+ LE +CR L+ LK ++EEE++R ++T+
Sbjct: 1236 DLASNVETVSKAKGNLEKMCRTLEDQLSELK------SKEEEQQRLINDLTAQRGRLQTE 1289
Query: 250 ---FQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSII---------------DQYEL 291
F L + + + Q S Q+ EL +L+ I D L
Sbjct: 1290 SGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLL 1349
Query: 292 REEHLDKIFKHRELQQKLVDAKLEQAQ----------EMMKEAEERHKREKEYLLNQAAE 341
RE++ ++ ELQ+ L A E AQ + +E EE K+ + L QAAE
Sbjct: 1350 REQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRL--QAAE 1407
Query: 342 WKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKD 401
++A + + L+ E+ + ++N A KK + +K
Sbjct: 1408 EHVEA--VNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAAL-------DKKQRNFDKI 1458
Query: 402 TATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENL--CRALQEERNELHKKIR 459
A WK + E + L +K R+ E F +K E+L L+ E L ++I
Sbjct: 1459 LAEWKQKCEETHAEL--EASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEIS 1516
Query: 460 DAEISEKDDQSQHNSDEEPESNVSVDQE 487
D ++E+ + E + V+QE
Sbjct: 1517 D--LTEQIAEGGKRIHELEKIKKQVEQE 1542
Score = 44.7 bits (104), Expect = 3e-04
Identities = 50/246 (20%), Positives = 111/246 (45%), Gaps = 11/246 (4%)
Query: 154 KLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSK 213
+L E + + L + EL ++ K+ +++ + + L +++ I + K
Sbjct: 1676 QLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKK 1735
Query: 214 LESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQ 273
LE+ ++Q E+ LQ AR EEK K+ + +++ EQ + +++ +
Sbjct: 1736 LETDISQMQGE----MEDILQEARNAEEKAKKAITDAAMMAEELKK--EQDTSAHLERMK 1789
Query: 274 ENTELAEK-LKSIIDQYE-LREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEE---RH 328
+N E K L+ +D+ E L + K + E + + ++ ++E Q+ EA + +H
Sbjct: 1790 KNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKH 1849
Query: 329 KREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEM 388
+R + L Q E + L++ LQA++ Y + EE + + F + E+
Sbjct: 1850 ERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHEL 1909
Query: 389 DKTTKK 394
++ ++
Sbjct: 1910 EEAEER 1915
Score = 43.5 bits (101), Expect = 6e-04
Identities = 49/214 (22%), Positives = 93/214 (43%), Gaps = 46/214 (21%)
Query: 117 GEPPTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEH 176
GE + + N E+K +K I +A ++ + L K Q + + K E
Sbjct: 1745 GEMEDILQEARNAEEKAKKAIT-----DAAMMAEELKKEQDTSAHLERMKKNM-----EQ 1794
Query: 177 RTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKE---EAL 233
+ +L+L + +Q+ ++ K Q+Q KLE+ REL+ ++ ++ EA+
Sbjct: 1795 TVKDLQLRLDEAEQLALKGGKKQIQ-----------KLEARVRELEGEVESEQKRNAEAV 1843
Query: 234 QRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELRE 293
+ R+ E + KE+T Q+E + K +L +KL++ + Y+ +
Sbjct: 1844 KGLRKHERRVKELT---------------YQTEEDRKNILRLQDLVDKLQAKVKSYKRQA 1888
Query: 294 EHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEER 327
E ++ Q AK + Q ++EAEER
Sbjct: 1889 EEAEE-------QSNTNLAKFRKLQHELEEAEER 1915
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 78.6 bits (192), Expect = 2e-14
Identities = 123/590 (20%), Positives = 236/590 (40%), Gaps = 88/590 (14%)
Query: 83 ARASEQPENAESPDNEDGDCEETTEEAGREPVASGEPPTVKE------PVSNKEQKLEKK 136
A+ E E AE D E+ + E T ++ E S + + V ++ E K
Sbjct: 923 AKIKEVTERAE--DEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 980
Query: 137 ILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKE 196
+ K L +E L + + KL T E+K L + + + LD+ + E+ K+ L K +++++++
Sbjct: 981 V-KNLTEEMAGLDETIAKL-TKEKKA--LQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQ 1036
Query: 197 KDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTD 256
D L+G + R LE R+L+ K L +E++ E+++ E + +++
Sbjct: 1037 VDDLEGSLEQEKKLRMDLERAKRKLEGDLK-LAQESIMDIENEKQQLDEKLKKKEFEISN 1095
Query: 257 IQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQ 316
+Q +IE + ++L ++ EL +++ + ++ E K E Q+ + +LE+
Sbjct: 1096 LQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAK----AEKQRSDLSRELEE 1151
Query: 317 AQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTK 376
E ++EA + E + AE++ + L +E LQ + T +TL K
Sbjct: 1152 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDL--EEATLQHEAT---------AATLRK 1200
Query: 377 SN-EVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVM 435
+ + A +++D + +KLEK+ + K ++ A E
Sbjct: 1201 KHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL--------------ASNVETVSK 1246
Query: 436 KIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEPESNVSVDQEIDAEEVNS 495
G LE +CR L+++ +EL K E++ Q N + + + +++
Sbjct: 1247 AKGNLEKMCRTLEDQLSELKSK-------EEEQQRLINDLTAQRGRLQTESGEFSRQLDE 1299
Query: 496 VQTAVKNLATAFMIIHHPESTPHQSKETQPEIGSSQESADAALKEPEQPPLIPSRDSESP 555
+ V L+ + ++ + EI + A A + S
Sbjct: 1300 KEALVSQLSRGKQAF--TQQIEELKRQLEEEIKAKNALAHAL------------QSSRHD 1345
Query: 556 LPPLTPQAEAEGGSDAEPPSKASNSPAGLGAETQCEGLPVGAQADQASWKPEAEASGQAP 615
L Q E E S AE S A + A W+ + E
Sbjct: 1346 CDLLREQYEEEQESKAELQRALSK-----------------ANTEVAQWRTKYETDAIQR 1388
Query: 616 QAPTEASLQKMEADVPAPACAAEEHVAAMVPAC---EPSRQPPRAAAEEL 662
E + +K+ + AAEEHV A+ C E ++Q + E+L
Sbjct: 1389 TEELEEAKKKLAQRLQ----AAEEHVEAVNAKCASLEKTKQRLQNEVEDL 1434
Score = 58.2 bits (139), Expect = 3e-08
Identities = 78/389 (20%), Positives = 168/389 (43%), Gaps = 28/389 (7%)
Query: 127 SNKEQKLEKKILKGLGKEA----NLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKK 182
++ E + +K + LG E N ++L++L+T + + L ++ ++L ++ K+
Sbjct: 1469 THAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKR 1528
Query: 183 LKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEK 242
+ L+K + Q+++EK +LQ A + E +Q +K E ++ E++E+
Sbjct: 1529 IHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEE 1588
Query: 243 RKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKH 302
++ + + +Q ++ + ++ + L +K++ +++ E++ H +++
Sbjct: 1589 IDQLKRNHIRIVESMQSTLDAE----IRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAE 1644
Query: 303 RELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQL-- 360
+ L+ Q + +A R +E L Q A + +A +L+ + L+A L
Sbjct: 1645 ALRNYRNTQGILKDTQIHLDDA----LRSQEDLKEQLAMVERRANLLQAEIEELRATLEQ 1700
Query: 361 TLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFE-------NCN 413
T S + E Q L S V Q K KKLE D + + E N
Sbjct: 1701 TERSRKIAE-QELLDASERVQLLHTQNTSLINTK-KKLETDISQMQGEMEDILQEARNAE 1758
Query: 414 KALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEI-----SEKDD 468
+ I + A+ A+E + LE + + +++ +L ++ +AE +K
Sbjct: 1759 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQI 1818
Query: 469 QSQHNSDEEPESNVSVDQEIDAEEVNSVQ 497
Q E E V +Q+ +AE V ++
Sbjct: 1819 QKLEARVRELEGEVESEQKRNAEAVKGLR 1847
Score = 57.0 bits (136), Expect = 6e-08
Identities = 102/448 (22%), Positives = 177/448 (39%), Gaps = 76/448 (16%)
Query: 80 EGSARASEQPENAESPDNEDGDCEETTEEAGREPVASGEPPTVKEPVSNKEQK-LEKKIL 138
E ++RA + + ++ E + E EEAG A E +E K ++ LE+ L
Sbjct: 1131 ERASRAKAEKQRSDL-SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL 1189
Query: 139 KGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKD 198
+ A L ++ + + E+ D L R +QK L+K++ +++ E D
Sbjct: 1190 QHEATAATLRKKHADSVAELGEQIDNL----------QRVKQK----LEKEKSEMKMEID 1235
Query: 199 QLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKR--KEITSH------- 249
L A+ LE +CR L+ LK ++EEE++R ++T+
Sbjct: 1236 DLASNVETVSKAKGNLEKMCRTLEDQLSELK------SKEEEQQRLINDLTAQRGRLQTE 1289
Query: 250 ---FQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSII---------------DQYEL 291
F L + + + Q S Q+ EL +L+ I D L
Sbjct: 1290 SGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLL 1349
Query: 292 REEHLDKIFKHRELQQKLVDAKLEQAQ----------EMMKEAEERHKREKEYLLNQAAE 341
RE++ ++ ELQ+ L A E AQ + +E EE K+ + L QAAE
Sbjct: 1350 REQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRL--QAAE 1407
Query: 342 WKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKD 401
++A + + L+ E+ + ++N A KK + +K
Sbjct: 1408 EHVEA--VNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAAL-------DKKQRNFDKI 1458
Query: 402 TATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENL--CRALQEERNELHKKIR 459
A WK + E + L +K R+ E F +K E+L L+ E L ++I
Sbjct: 1459 LAEWKQKCEETHAEL--EASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEIS 1516
Query: 460 DAEISEKDDQSQHNSDEEPESNVSVDQE 487
D ++E+ + E + V+QE
Sbjct: 1517 D--LTEQIAEGGKRIHELEKIKKQVEQE 1542
Score = 44.7 bits (104), Expect = 3e-04
Identities = 50/246 (20%), Positives = 111/246 (45%), Gaps = 11/246 (4%)
Query: 154 KLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSK 213
+L E + + L + EL ++ K+ +++ + + L +++ I + K
Sbjct: 1676 QLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKK 1735
Query: 214 LESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQ 273
LE+ ++Q E+ LQ AR EEK K+ + +++ EQ + +++ +
Sbjct: 1736 LETDISQMQGE----MEDILQEARNAEEKAKKAITDAAMMAEELKK--EQDTSAHLERMK 1789
Query: 274 ENTELAEK-LKSIIDQYE-LREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEE---RH 328
+N E K L+ +D+ E L + K + E + + ++ ++E Q+ EA + +H
Sbjct: 1790 KNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKH 1849
Query: 329 KREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEM 388
+R + L Q E + L++ LQA++ Y + EE + + F + E+
Sbjct: 1850 ERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHEL 1909
Query: 389 DKTTKK 394
++ ++
Sbjct: 1910 EEAEER 1915
Score = 43.5 bits (101), Expect = 6e-04
Identities = 49/214 (22%), Positives = 93/214 (43%), Gaps = 46/214 (21%)
Query: 117 GEPPTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEH 176
GE + + N E+K +K I +A ++ + L K Q + + K E
Sbjct: 1745 GEMEDILQEARNAEEKAKKAIT-----DAAMMAEELKKEQDTSAHLERMKKNM-----EQ 1794
Query: 177 RTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKE---EAL 233
+ +L+L + +Q+ ++ K Q+Q KLE+ REL+ ++ ++ EA+
Sbjct: 1795 TVKDLQLRLDEAEQLALKGGKKQIQ-----------KLEARVRELEGEVESEQKRNAEAV 1843
Query: 234 QRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELRE 293
+ R+ E + KE+T Q+E + K +L +KL++ + Y+ +
Sbjct: 1844 KGLRKHERRVKELT---------------YQTEEDRKNILRLQDLVDKLQAKVKSYKRQA 1888
Query: 294 EHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEER 327
E ++ Q AK + Q ++EAEER
Sbjct: 1889 EEAEE-------QSNTNLAKFRKLQHELEEAEER 1915
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 77.8 bits (190), Expect = 3e-14
Identities = 93/414 (22%), Positives = 187/414 (45%), Gaps = 45/414 (10%)
Query: 83 ARASEQPENAESPDNEDGDCEETTEEAGREPVASGEPPTVKE------PVSNKEQKLEKK 136
A+ E E AE D E+ + E T ++ E S + + V ++ E K
Sbjct: 921 AKIKEVTERAE--DEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 978
Query: 137 ILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKE 196
+ K L +E L + + KL T E+K L + + + LD+ + E+ K+ L K +++++++
Sbjct: 979 V-KNLTEEMAGLDETIAKL-TKEKKA--LQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQ 1034
Query: 197 KDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTD 256
D L+G + R LE R+L+ K L +E+ ++++ E + ++
Sbjct: 1035 VDDLEGSLEQEKKIRMDLERAKRKLEGDLK-LAQESTMDIENDKQQLDEKLKKKEFEMSG 1093
Query: 257 IQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQ 316
+Q +IE + M+L ++ EL +++ + ++ E K E Q+ + +LE+
Sbjct: 1094 LQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAK----AEKQRSDLSRELEE 1149
Query: 317 AQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTK 376
E ++EA + E + AE++ + L +E LQ + T +TL K
Sbjct: 1150 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDL--EEATLQHEAT---------AATLRK 1198
Query: 377 SN-EVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVM 435
+ + A +++D + +KLEK+ + K ++ + E +AK
Sbjct: 1199 KHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNM-----ETVSKAK------- 1246
Query: 436 KIGRLENLCRALQEERNELHKKIRDAE--ISEKDDQSQHNSDEEPESNVSVDQE 487
G LE +CRAL+++ +E+ K + + I++ Q E E + +D++
Sbjct: 1247 --GNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEK 1298
Score = 66.2 bits (160), Expect = 9e-11
Identities = 101/511 (19%), Positives = 202/511 (39%), Gaps = 48/511 (9%)
Query: 1 MEANHSEQLSAERQSTPPGDSSSLPSHNGLEKEDGQDSPTPVQPPEKEASVHPDISEELN 60
+EA + + AE+Q + S LE+ G S ++EA +++
Sbjct: 1126 IEAERASRAKAEKQRSDLSRELEEISER-LEEAGGATSAQIEMNKKREAEF-----QKMR 1179
Query: 61 RQLEDIINTYGSAASTAGKEGSARASEQPENAESPDNEDGDCEETTEEAGREPVASGEPP 120
R LE+ + + A+T K+ A E E DN ++ +E + +
Sbjct: 1180 RDLEEATLQHEATAATLRKK---HADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLA 1236
Query: 121 TVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQ 180
+ E VS + LEK L L++++T EE+ L+++ ++
Sbjct: 1237 SNMETVSKAKGNLEKM--------CRALEDQLSEIKTKEEE-------QQRLINDLTAQR 1281
Query: 181 KKLKLLQKKQVQIQKEKDQLQGEHSRAILA-RSKLESLCRELQRH--NKTLKEEALQRAR 237
+L+ + + EKD L + SR A ++E L R+L+ K+ ALQ +R
Sbjct: 1282 ARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSR 1341
Query: 238 -------EEEEKRKEITSHFQSTLTDIQGQIEQ-QSERNMKLCQENTELAEKLKSIIDQY 289
E+ E+ +E + Q ++ ++ Q +++ Q EL E K + +
Sbjct: 1342 HDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1401
Query: 290 ELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAE---------ERHKREKEYLLNQAA 340
+ EEH++ + +K + +++M + E ++ +R + +L A
Sbjct: 1402 QDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKIL---A 1458
Query: 341 EWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEK 400
EWK + + + Q + S + ++ +S + T K+E +++ L +
Sbjct: 1459 EWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE 1518
Query: 401 DTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRD 460
A R K + +EK+ E + E +Q E N++ ++ D
Sbjct: 1519 QIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEV-D 1577
Query: 461 AEISEKDDQSQHNSDEEPESNVSVDQEIDAE 491
+I+EKD++ S+ +DAE
Sbjct: 1578 RKIAEKDEEIDQMKRNHIRIVESMQSTLDAE 1608
Score = 60.5 bits (145), Expect = 5e-09
Identities = 81/384 (21%), Positives = 175/384 (45%), Gaps = 25/384 (6%)
Query: 131 QKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQ 190
QK + + L K N ++L++L+T + + L ++ ++L ++ K++ L+K +
Sbjct: 1475 QKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIK 1534
Query: 191 VQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHF 250
Q+++EK +LQ A + E +Q +K E ++ E++E+ ++ +
Sbjct: 1535 KQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNH 1594
Query: 251 QSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLV 310
+ +Q ++ + ++ + L +K++ +++ E++ H +++ +
Sbjct: 1595 IRIVESMQSTLDAE----IRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNT 1650
Query: 311 DAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQL--TLYSGRFE 368
A L+ Q + +A R +E L Q A + +A +L+ + L+A L T S +
Sbjct: 1651 QAILKDTQLHLDDA----LRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIA 1706
Query: 369 EFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFE-------NCNKALLDMIE 421
E Q L S V Q K KKLE D + + E N + I
Sbjct: 1707 E-QELLDASERVQLLHTQNTSLINTK-KKLETDISQIQGEMEDIIQEARNAEEKAKKAIT 1764
Query: 422 EKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAE-ISEKDDQSQHNSDEEPES 480
+ A+ A+E + LE + + L++ +L ++ +AE ++ K + Q ++ E+
Sbjct: 1765 DAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQ---IQKLEA 1821
Query: 481 NV-SVDQEIDAEEVNSVQTAVKNL 503
V ++ E+++E+ +V+ AVK L
Sbjct: 1822 RVRELEGEVESEQKRNVE-AVKGL 1844
Score = 44.3 bits (103), Expect = 4e-04
Identities = 49/246 (19%), Positives = 112/246 (45%), Gaps = 11/246 (4%)
Query: 154 KLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSK 213
+L E + + L + EL ++ K+ +++ + + L +++ I + K
Sbjct: 1674 QLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKK 1733
Query: 214 LESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQ 273
LE+ ++Q E+ +Q AR EEK K+ + +++ EQ + +++ +
Sbjct: 1734 LETDISQIQGE----MEDIIQEARNAEEKAKKAITDAAMMAEELKK--EQDTSAHLERMK 1787
Query: 274 ENTELAEK-LKSIIDQYE-LREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEE---RH 328
+N E K L+ +D+ E L + K + E + + ++ ++E Q+ EA + +H
Sbjct: 1788 KNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKH 1847
Query: 329 KREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEM 388
+R+ + L Q E + L++ LQA++ Y + EE + + F + E+
Sbjct: 1848 ERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHEL 1907
Query: 389 DKTTKK 394
++ ++
Sbjct: 1908 EEAEER 1913
Score = 42.7 bits (99), Expect = 0.001
Identities = 40/205 (19%), Positives = 94/205 (45%), Gaps = 15/205 (7%)
Query: 127 SNKEQKLEKKILKGLGKEANLL-MQNLNKLQTP---EEKFDFLFKKYAELLDEHRTEQKK 182
+ + +K+ ++ L + LL QN + + T E + + +++ E R ++K
Sbjct: 1699 TERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEK 1758
Query: 183 LKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEK 242
K + +E + Q + + LE ++LQ ++ AL+ +++ +K
Sbjct: 1759 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK 1818
Query: 243 RKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKH 302
++ + +++G++E + +RN++ + + K+K + Q EE I +
Sbjct: 1819 -------LEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQ---TEEDRKNILRL 1868
Query: 303 RELQQKLVDAKLEQAQEMMKEAEER 327
++L KL AK++ + +EAEE+
Sbjct: 1869 QDLVDKL-QAKVKSYKRQAEEAEEQ 1892
Score = 39.7 bits (91), Expect = 0.009
Identities = 46/214 (21%), Positives = 93/214 (43%), Gaps = 39/214 (18%)
Query: 117 GEPPTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEH 176
GE + + N E+K +K I +A ++ + L K Q + + K E
Sbjct: 1743 GEMEDIIQEARNAEEKAKKAIT-----DAAMMAEELKKEQDTSAHLERMKKNL-----EQ 1792
Query: 177 RTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKE---EAL 233
+ + +L + +Q+ ++ K Q+Q KLE+ REL+ ++ ++ EA+
Sbjct: 1793 TVKDLQHRLDEAEQLALKGGKKQIQ-----------KLEARVRELEGEVESEQKRNVEAV 1841
Query: 234 QRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELRE 293
+ R+ E K KE+T Q+E + K +L +KL++ + Y+ +
Sbjct: 1842 KGLRKHERKVKELT---------------YQTEEDRKNILRLQDLVDKLQAKVKSYKRQA 1886
Query: 294 EHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEER 327
E ++ + + + +LE+A+E AE +
Sbjct: 1887 EEAEEQSNVNLSKFRRIQHELEEAEERADIAESQ 1920
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 77.4 bits (189), Expect = 4e-14
Identities = 92/416 (22%), Positives = 182/416 (43%), Gaps = 43/416 (10%)
Query: 83 ARASEQPENAESPDNEDGDCEETTEEAGREPVASGEPPTVKE------PVSNKEQKLEKK 136
A+ E E E D E+ + E T ++ E S + + V ++ E K
Sbjct: 917 AKVKEMNERLE--DEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENK 974
Query: 137 ILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKE 196
+ K L +E L + + KL T E+K L + + + LD+ + E+ K+ L K +V+++++
Sbjct: 975 V-KNLTEEMAGLDEIIAKL-TKEKKA--LQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQ 1030
Query: 197 KDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTD 256
D L+G + R LE R+L+ K L +E++ ++++ E L
Sbjct: 1031 VDDLEGSLEQEKKVRMDLERAKRKLEGDLK-LTQESIMDLENDKQQLDERLKKKDFELNA 1089
Query: 257 IQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQ 316
+ +IE + +L ++ EL +++ + ++ E K+ K R + +LE+
Sbjct: 1090 LNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLR----SDLSRELEE 1145
Query: 317 AQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTK 376
E ++EA + E + AE++ + L +E LQ + T + R K
Sbjct: 1146 ISERLEEAGGATSVQIEMNKKREAEFQKMRRDL--EEATLQHEATAAALR--------KK 1195
Query: 377 SNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMK 436
+ A +++D + +KLEK+ + +K ++ + +I+ KA
Sbjct: 1196 HADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKA------------ 1243
Query: 437 IGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEPESNVSVDQEIDAEE 492
LE +CR L+++ NE K + + S D SQ + N + +++D +E
Sbjct: 1244 --NLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQ--TENGELSRQLDEKE 1295
Score = 73.2 bits (178), Expect = 8e-13
Identities = 89/437 (20%), Positives = 184/437 (42%), Gaps = 34/437 (7%)
Query: 55 ISEELNRQLEDI---INTYGSAASTAGKEGSARASEQPENAESPDNEDGDCEETTEEAGR 111
+ +L+R+LE+I + G A S + R +E + D E+ + A
Sbjct: 1135 LRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRR--DLEEATLQHEATAAAL 1192
Query: 112 EPVASGEPPTVKEPVSNKE---QKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKK 168
+ + E + N + QKLEK+ + E + + N+ ++ + + + +
Sbjct: 1193 RKKHADSVAELGEQIDNLQRVKQKLEKEKSE-FKLELDDVTSNMEQIIKAKANLEKMCRT 1251
Query: 169 YAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTL 228
+ ++EHR++ ++ Q+ + ++ +LQ E+ + E+L +L R T
Sbjct: 1252 LEDQMNEHRSKAEET---QRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTY 1308
Query: 229 KE--EALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSII 286
+ E L+R EEE K K +H + + +Q E + E + K S +
Sbjct: 1309 TQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEV 1368
Query: 287 DQYELREEHLDKIFKHRELQQ--KLVDAKLEQAQEM----------MKEAEERHKREKEY 334
Q+ + E D I + EL++ K + +L++A+E +++ + R + E E
Sbjct: 1369 AQWRTKYE-TDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIED 1427
Query: 335 LLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKK 394
L+ A L +++ L + ++EE QS L S + + E+ K
Sbjct: 1428 LMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNA 1487
Query: 395 MKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNEL 454
++ + T+K +N + + D+ E+ K I LE + + L+ E+ EL
Sbjct: 1488 YEESLEHLETFKRENKNLQEEISDLTEQLGSSGK-------TIHELEKVRKQLEAEKMEL 1540
Query: 455 HKKIRDAEISEKDDQSQ 471
+ +AE S + ++ +
Sbjct: 1541 QSALEEAEASLEHEEGK 1557
Score = 60.1 bits (144), Expect = 7e-09
Identities = 70/399 (17%), Positives = 174/399 (43%), Gaps = 48/399 (12%)
Query: 131 QKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQ 190
QK + + L K N ++L L+T + + L ++ ++L ++ + K + L+K +
Sbjct: 1471 QKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVR 1530
Query: 191 VQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHF 250
Q++ EK +LQ A + E Q +K E ++ E++E+ ++ +
Sbjct: 1531 KQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNH 1590
Query: 251 QSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLV 310
+ +Q ++ ++ E + +K++ +++ E++ H +++ + Q K +
Sbjct: 1591 LRVVDSLQTSLDAETRSR----NEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSL 1646
Query: 311 DAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEF 370
+ L+ Q + +A + KE + +++ + +LQA+L EE
Sbjct: 1647 QSLLKDTQIQLDDAVRANDDLKENI-----------AIVERRNNLLQAEL-------EEL 1688
Query: 371 QSTLTKSNEVFATFKQEMDKTTKKM--------------KKLEKDTATWKARFE------ 410
++ + ++ +QE+ +T++++ KK++ D + + E
Sbjct: 1689 RAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQEC 1748
Query: 411 -NCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAE-ISEKDD 468
N + I + A+ A+E + LE + + +++ +L ++ +AE I+ K
Sbjct: 1749 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGG 1808
Query: 469 QSQHNSDE----EPESNVSVDQEIDAEEVNSVQTAVKNL 503
+ Q E E E+ + +Q+ +AE V ++ + + +
Sbjct: 1809 KKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRI 1847
Score = 48.9 bits (115), Expect = 2e-05
Identities = 80/347 (23%), Positives = 153/347 (44%), Gaps = 50/347 (14%)
Query: 179 EQKKLKLLQKK---QVQIQKEKDQLQGEHSRA---ILARSKLESLCRELQRHNKTLKEEA 232
E+K + LLQ+K Q+Q+Q E+D L R I + +LE+ +E+ N+ L++E
Sbjct: 874 EEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEM---NERLEDEE 930
Query: 233 LQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELR 292
A +KRK + ++++ I+ K+ +E K+K++ ++
Sbjct: 931 EMNAELTAKKRK-----LEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL 985
Query: 293 EEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKV---- 348
+E + K+ K ++ Q+ L+ Q AEE +K L + A+ KL+ +V
Sbjct: 986 DEIIAKLTKEKKALQEAHQQALDDLQ-----AEE----DKVNTLTK-AKVKLEQQVDDLE 1035
Query: 349 -LKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKA 407
EQE ++ L + E L + E + + + +++KK + + A
Sbjct: 1036 GSLEQEKKVRMDLERAKRKLE---GDLKLTQESIMDLENDKQQLDERLKKKDFELNALNA 1092
Query: 408 RFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHK--KIRD----- 460
R E+ +AL +++K KE + R+E L L+ ER K K+R
Sbjct: 1093 RIED-EQALGSQLQKK---LKELQ------ARIEELEEELEAERTARAKVEKLRSDLSRE 1142
Query: 461 -AEISEKDDQSQHNSDEEPESNVSVDQEIDAEEVNSVQTAVKNLATA 506
EISE+ +++ + + E N + E + + +++ ATA
Sbjct: 1143 LEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATA 1189
Score = 38.5 bits (88), Expect = 0.021
Identities = 43/217 (19%), Positives = 90/217 (41%), Gaps = 18/217 (8%)
Query: 127 SNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDF----LFKKYAELLDEHRTEQKK 182
+ + +KL ++ L + LL L ++K D L + E + E R ++K
Sbjct: 1695 TERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEK 1754
Query: 183 LKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEK 242
K + +E + Q + + +E ++LQ ++ AL+ +++ +K
Sbjct: 1755 AKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQK 1814
Query: 243 --------RKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEK----LKSIIDQYE 290
E+ + + ++G ++SER +K TE K L+ ++D+ +
Sbjct: 1815 LEARVRELENELEAEQKRNAESVKGM--RKSERRIKELTYQTEEDRKNLLRLQDLVDKLQ 1872
Query: 291 LREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEER 327
L+ + + + E Q +K + Q + EAEER
Sbjct: 1873 LKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEER 1909
Score = 34.3 bits (77), Expect = 0.39
Identities = 43/205 (20%), Positives = 88/205 (42%), Gaps = 43/205 (20%)
Query: 128 NKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDE--HRTEQKKLKL 185
N E+K +K I +A ++ + L K Q + + K + + + HR ++ +
Sbjct: 1750 NAEEKAKKAIT-----DAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAE--- 1801
Query: 186 LQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKE---EALQRAREEEEK 242
Q+ ++ K QLQ KLE+ REL+ + ++ E+++ R+ E +
Sbjct: 1802 ----QIALKGGKKQLQ-----------KLEARVRELENELEAEQKRNAESVKGMRKSERR 1846
Query: 243 RKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKH 302
KE+T Q+E + K +L +KL+ + Y+ + E ++
Sbjct: 1847 IKELT---------------YQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANT 1891
Query: 303 RELQQKLVDAKLEQAQEMMKEAEER 327
+ + V +L++A+E AE +
Sbjct: 1892 NLSKFRKVQHELDEAEERADIAESQ 1916
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 77.4 bits (189), Expect = 4e-14
Identities = 88/368 (23%), Positives = 175/368 (47%), Gaps = 54/368 (14%)
Query: 116 SGEPPTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDE 175
+GE VS + +K ++ I + L KE + L L + E+ L KK AEL
Sbjct: 178 AGELQRALSAVSTRHKKADRYI-EELTKERDALSLELYRNTITNEE---LKKKNAEL--- 230
Query: 176 HRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRA--ILARSKLESLCRELQRHNKTLKEEAL 233
Q+KL L + ++ +IQ +L+ + RA +L + + +L E+ R + L+E+
Sbjct: 231 ----QEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEK 286
Query: 234 QRAREEEEKRKEITSHFQSTLTDIQGQIEQQSER----NMKLCQENTELAEKLKSIIDQY 289
+ ++EE+ ++ + L + +G++ +Q E+ +L ++ EL E+ K + +Q
Sbjct: 287 KIRKQEEKMWRQ-----EERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQK 341
Query: 290 ELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVL 349
ELRE+ E Q + + K+ + +E M+E EE+ R++E L Q + + Q + +
Sbjct: 342 ELREQ---------EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKM 392
Query: 350 KEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARF 409
++QE + Q R E + + + +++ + E + KKM++ EK T + +
Sbjct: 393 RDQEERMWEQ----DERLREKEERMREQEKMWE--QVEKMREEKKMQEQEKKTRDQEEK- 445
Query: 410 ENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQ 469
M EE+ +R +E K+ E R +E+ + + + + E EK+ Q
Sbjct: 446 ---------MQEEERIRERE-----KKMREEEETMREQEEKMQKQEENMWEQE--EKEWQ 489
Query: 470 SQHNSDEE 477
Q +++
Sbjct: 490 QQRLPEQK 497
Score = 70.5 bits (171), Expect = 5e-12
Identities = 79/442 (17%), Positives = 187/442 (42%), Gaps = 49/442 (11%)
Query: 113 PVASGEPPTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAEL 172
P+A E ++ V ++KLE+ A L+ + EE ++++ EL
Sbjct: 235 PLAESEKSEIQLNVKELKRKLER---------AKFLLPQVQTNTLQEE----MWRQEEEL 281
Query: 173 LDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEA 232
++ + +K+ + + +++ ++++++ +++ + + +L +EL+ K L+E+
Sbjct: 282 REQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQ- 340
Query: 233 LQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYEL- 291
+ RE+EE+ +E ++ Q E+ + +L ++ ++ E+ + + DQ E
Sbjct: 341 -KELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERM 399
Query: 292 ---------REEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEW 342
+EE + + K E +K+ + K Q QE +E +E+E + + +
Sbjct: 400 WEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKM 459
Query: 343 KLQAKVLKEQETVLQAQ-LTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKD 401
+ + + ++EQE +Q Q ++ +E+Q ++ +K ++ K E++
Sbjct: 460 REEEETMREQEEKMQKQEENMWEQEEKEWQQ---------QRLPEQKEKLWEQEKMQEQE 510
Query: 402 TATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDA 461
W+ EEK +E K+ R E + R +++ E +K+RD
Sbjct: 511 EKIWEQ-------------EEKIRDQEEMWGQEKKMWRQEKM-REQEDQMWEQEEKMRDQ 556
Query: 462 EISEKDDQSQHNSDEEPESNVSVDQEIDAEEVNSVQTAVKNLATAFMIIHHPESTPHQSK 521
E D + + + + + DQE E ++ K + ++ E + +
Sbjct: 557 EQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQE 616
Query: 522 ETQPEIGSSQESADAALKEPEQ 543
E E + ++E E+
Sbjct: 617 EKMQEQEEKMWEQEEKMQEQEE 638
Score = 59.3 bits (142), Expect = 1e-08
Identities = 80/398 (20%), Positives = 166/398 (41%), Gaps = 63/398 (15%)
Query: 87 EQPENAESPDNEDGDCEETTEEAGREPVASGEPPTVKEPVSNKEQKLEKKILKGLGKEAN 146
EQ E + + D EE E+ +E E T + +E++ ++ K + +E
Sbjct: 548 EQEEKMRDQEQKMWDQEERMEKKTQEQ----EKKTWDQEEKMREEERMREREKKMREEEE 603
Query: 147 LLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQK--EKDQLQGEH 204
++ + K+Q EEK E+K + +K Q Q +K E+++ E
Sbjct: 604 MMREQEEKMQEQEEKMQ-------------EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQ 650
Query: 205 SRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQ 264
+ + +L +L H K ++E +Q E+EEK E Q ++E++
Sbjct: 651 EEKMWEQQRLPEQKEKLWEHEKMQEQEKMQ---EQEEKIWE------------QEKMEKK 695
Query: 265 SERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEA 324
++ E+ K DQ ++REE + + RE K+ + +EMM+E
Sbjct: 696 TQ-------------EQEKKTWDQEKMREE---ESMRERE-------KKMREEEEMMREQ 732
Query: 325 EERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATF 384
EE+ + ++E + Q E Q + + EQE + Q L + + ++ + E
Sbjct: 733 EEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQ 792
Query: 385 KQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIE-----EKALRAKEYECFVMKIGR 439
+++M +KM+ E+ + + + + E E+ + +E + + + +
Sbjct: 793 EEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQE-EK 851
Query: 440 LENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEE 477
+E + +E+ E +K+R E ++ + + EE
Sbjct: 852 MEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEE 889
Score = 45.1 bits (105), Expect = 2e-04
Identities = 62/309 (20%), Positives = 130/309 (42%), Gaps = 21/309 (6%)
Query: 249 HFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQK 308
HF L + + ++ + +E T+ + L + + + E L K K+ ELQ+K
Sbjct: 176 HFAGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKK--KNAELQEK 233
Query: 309 LVDAKLEQAQEMMKEAEERHKREK-EYLLNQAAEWKLQAKV------LKEQETVLQAQ-- 359
L A+ E+++ + E + K E+ ++LL Q LQ ++ L+EQE ++ Q
Sbjct: 234 LPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 293
Query: 360 -LTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWK---ARFENCNKA 415
+ R E + + + E ++ + + K++++ EK+ K + E +
Sbjct: 294 KMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQ 353
Query: 416 LLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAE--ISEKDDQSQHN 473
M E++ ++ E K+ R E +++ E +K+RD E + E+D++ +
Sbjct: 354 EEKMWEQEEKMREQEE----KMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREK 409
Query: 474 SDEEPESNVSVDQEIDAEEVNSVQTAVKNLATAFMIIHHPESTPHQSKETQPEIGSSQES 533
+ E +Q E +Q K + E + K+ + E + +E
Sbjct: 410 EERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQ 469
Query: 534 ADAALKEPE 542
+ K+ E
Sbjct: 470 EEKMQKQEE 478
Score = 42.7 bits (99), Expect = 0.001
Identities = 51/267 (19%), Positives = 121/267 (45%), Gaps = 18/267 (6%)
Query: 80 EGSARASEQPENAESPDNEDGDCEETTEEAGREP-----VASGEPPTVKEPVSNKEQKL- 133
E + EQ E + + + EE E R P + E +E + +E+K+
Sbjct: 628 EQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIW 687
Query: 134 EKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQI 193
E++ ++ +E + K++ EE KK E + R +++K++ ++K +
Sbjct: 688 EQEKMEKKTQEQEKKTWDQEKMRE-EESMREREKKMREEEEMMREQEEKMQEQEEKMQEQ 746
Query: 194 QKE---KDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEAL----QRAREEEEKRKEI 246
++E +++ E + + +L +L H K ++E + ++ R++EEK +
Sbjct: 747 EEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQ 806
Query: 247 TSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQ 306
+ ++GQ E+ + K+ + EK+ ++ +EE +++ + +E +
Sbjct: 807 EEKMRGQEEKMRGQEEKMWGQEEKMWGQE----EKMWGQEEKMWGQEEKMEEKMQGQEEK 862
Query: 307 QKLVDAKLEQAQEMMKEAEERHKREKE 333
+ + K+ +E M+E EE+ + ++E
Sbjct: 863 MREQEEKMRGQEEKMREQEEKMRGQEE 889
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 75.9 bits (185), Expect = 1e-13
Identities = 85/415 (20%), Positives = 178/415 (42%), Gaps = 42/415 (10%)
Query: 59 LNRQLEDIINTYGSAASTAGKEGSARASEQPENAESPDNEDGD-CEETTEEAGREPVASG 117
LN+Q+++ ++ TA +E + G+ C++ T+ + +
Sbjct: 1897 LNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLES 1956
Query: 118 EPPTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHR 177
E +K+ VS E++ ++ + + E+ + + L K+Q +++ K +A+ L E
Sbjct: 1957 EMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGN--KSHAKELQELL 2014
Query: 178 TE-QKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRA 236
E Q+++K LQK ++ Q++ L+ R + A LE + E Q+ + KE Q
Sbjct: 2015 KEKQQEVKQLQKDCIRYQEKISALE----RTVKA---LEFVQTESQKDLEITKENLAQAV 2067
Query: 237 REEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHL 296
++ + E+ S F+ L D Q + + N+KL +E E +KS + Q
Sbjct: 2068 EHRKKAQAELAS-FKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQ-------- 2118
Query: 297 DKIFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVL 356
K E + +++AEE+H +EK+ + + + + L+E +
Sbjct: 2119 ----------------KDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEI 2162
Query: 357 QAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKAL 416
Q L ++ Q L + A F + M ++ + W+ +F + ++
Sbjct: 2163 QVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQS- 2221
Query: 417 LDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQ 471
+E+ +R KE C V+K +L + ++E + + + D +I E Q++
Sbjct: 2222 ----KEEEIRLKEDNCSVLK-DQLRQMSIHMEELKINISRLEHDKQIWESKAQTE 2271
Score = 69.7 bits (169), Expect = 8e-12
Identities = 100/488 (20%), Positives = 198/488 (40%), Gaps = 85/488 (17%)
Query: 30 LEKEDGQDSPTPVQPPEKEASVHPDISEELNRQLEDIINTYGSAASTAGKEGSARASE-Q 88
+ K++ S Q EKEA++ I E+ Q ED+I + KE R + Q
Sbjct: 1401 ISKKEEDVSYLSGQLSEKEAAL-TKIQTEIIEQ-EDLIKALHTQLEMQAKEHDERIKQLQ 1458
Query: 89 PENAESPDNEDGDCEETTEEAGREPVASGEPPTVKEPVSNKEQKLEKKILKGLGKEANLL 148
E E ++ EE G E S +Q++++K+ L L
Sbjct: 1459 VELCEM--------KQKPEEIGEE--------------SRAKQQIQRKLQAALISRKEAL 1496
Query: 149 MQNLN---KLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHS 205
+N + +L + L K A++ + + K+ + + +Q+E+D+L E
Sbjct: 1497 KENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMD 1556
Query: 206 RAILARSKLESLCRELQ--------------RHNKTLKEEALQRAREEEEKRKEITSHFQ 251
R++L L S C L+ + ++LK + + E +EK KE+ ++
Sbjct: 1557 RSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYE 1616
Query: 252 STLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVD 311
L QS N+ + AE+++ +++ ++ L + E +K +
Sbjct: 1617 ILL---------QSYENV------SNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETE 1661
Query: 312 AKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQ 371
+L++A++ M+E +E+ ++ + + E L+E+ L+A++ +E
Sbjct: 1662 KQLQEAEQEMEEMKEKMRKFAKSKQQKILE-------LEEENDRLRAEVHPAGDTAKECM 1714
Query: 372 STLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYE 431
TL SN A+ K+E+++ K +E +K ++ EK ++E +
Sbjct: 1715 ETLLSSN---ASMKEELERV--------------KMEYETLSKKFQSLMSEKDSLSEEVQ 1757
Query: 432 CFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEPESNVSVDQEIDAE 491
+I N+ + E E H ++E+ QS EE +S + +E
Sbjct: 1758 DLKHQIE--GNVSKQANLEATEKHD--NQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSE 1813
Query: 492 EVNSVQTA 499
V S ++A
Sbjct: 1814 SVPSAKSA 1821
Score = 63.5 bits (153), Expect = 6e-10
Identities = 81/434 (18%), Positives = 185/434 (42%), Gaps = 32/434 (7%)
Query: 135 KKILKGLGKEANLLMQNLNKLQTP--------EEKFDFLFKKYAELLDEHRTEQKKLKLL 186
K L+GL ++ L++ + L++ +EK L K+Y LL + + + +
Sbjct: 1573 KLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERI 1632
Query: 187 QKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEI 246
Q +++EK +L G+ + + E +E ++ + +KE+ + A+ +++K E+
Sbjct: 1633 QHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILEL 1692
Query: 247 TSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRE-L 305
++ + E L N + E+L+ + +YE + + ++ L
Sbjct: 1693 EEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSL 1752
Query: 306 QQKLVDAKLEQAQEMMKEA--EERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLY 363
+++ D K + + K+A E K + + + + + + +EQ+++ +
Sbjct: 1753 SEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGET-EEQDSLSMSTRPTC 1811
Query: 364 SGRFEEFQSTLTKSNEVFAT------FKQEMDKTTKKMKKLEKD---TATWKARFENCNK 414
S +S ++ F++ + Q++D+ +++ LE++ + EN
Sbjct: 1812 SESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKN 1871
Query: 415 ALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNS 474
LL I K K + V K+ L + +QEE + + K+++ EKDD +
Sbjct: 1872 TLLSQISTKDGELKMLQEEVTKMNLLN---QQIQEELSRV-TKLKETAEEEKDDLEERLM 1927
Query: 475 DEEPESNVSVD---QEIDAEEVNS--VQTAVKNLATAFMIIHHPESTPHQSK-ETQPEIG 528
++ E N S+ Q++ ++ + +++ +KNL + + + K + + EI
Sbjct: 1928 NQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIR 1987
Query: 529 SSQ-ESADAALKEP 541
E A KEP
Sbjct: 1988 KEYLEKIQGAQKEP 2001
Score = 63.5 bits (153), Expect = 6e-10
Identities = 101/466 (21%), Positives = 191/466 (40%), Gaps = 70/466 (15%)
Query: 57 EELNRQLEDIINTYGSAASTAGK-EGSARASEQP-ENAE-SPDNEDGDCEETTEEAGR-- 111
+ L QL D+ N+ G EG R E +N++ S + + D + + E R
Sbjct: 2315 KSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLH 2374
Query: 112 EPVASGEPPTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAE 171
E + E + +S KE+ ++ I + + + + N L EE+ L ++ +
Sbjct: 2375 EEINMKEQKIISL-LSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKK 2433
Query: 172 LLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTL--- 228
+D+ + LK ++K+ +Q + + D S R ++ ++L+ + ++
Sbjct: 2434 AVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILE 2493
Query: 229 KEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQ 288
K++ +Q A E K KE +S + D+ + N KL E + E L +I
Sbjct: 2494 KDQLIQEAAAENNKLKEEIRGLRSHMDDLNSE-------NAKLDAELIQYREDLNQVITI 2546
Query: 289 YELREEHLDKIFKHRELQQ-KLVDAKLEQAQEMMKEAEERH----------KREKEYLLN 337
+ +++ L ++ +LQQ K ++ K + +E +KE+EE + + EK+ L
Sbjct: 2547 KDSQQKQLLEV----QLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSK 2602
Query: 338 QAAEWKLQAKVLKEQETVLQ---------AQLTLYSGRFEEFQSTLTKSNEVFATFKQEM 388
+ K+ L Q T LQ AQL + + + S + A ++E+
Sbjct: 2603 EIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEEL 2662
Query: 389 ---------------DKTTKKMKKLEKD-------TATWKARFENCNKALLDMIEEKALR 426
DK K++K L D T T + R + L++M ++ +
Sbjct: 2663 VCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMV 2722
Query: 427 AKE-------YECFVMKIGRLENLCRALQEERNELHKKIRDAEISE 465
KE + F + L+N EE +EL +K DA + E
Sbjct: 2723 TKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKY-DASLKE 2767
Score = 59.3 bits (142), Expect = 1e-08
Identities = 89/450 (19%), Positives = 180/450 (40%), Gaps = 77/450 (17%)
Query: 80 EGSARASEQPENAESPDNEDGDCEETTEEAGREPVASGEPPTVKEPVSNKEQKLEKKILK 139
+G +++Q E+ S + + TE+ +PV E + S+ E + L+
Sbjct: 1245 DGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVL--ESNLCPDWPSHSE---DASALQ 1299
Query: 140 GLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQ 199
G G + L +++ EK + EL T + K + Q+Q Q K
Sbjct: 1300 G-GTSVAQIKAQLKEIEA--EKVEL------ELKVSSTTSELTKKSEEVFQLQEQINKQG 1350
Query: 200 LQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQG 259
L+ E + + +++ + + + + L+ L+ RE + K E+ D+
Sbjct: 1351 LEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSY 1410
Query: 260 QIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQAQ- 318
Q SE+ L + TE+ E +E+ + + E+Q K D +++Q Q
Sbjct: 1411 LSGQLSEKEAALTKIQTEIIE-----------QEDLIKALHTQLEMQAKEHDERIKQLQV 1459
Query: 319 EMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETV-----LQAQLTLYSGRFE----- 368
E+ + ++ + +E Q + KLQA ++ +E + LQ +L+L G E
Sbjct: 1460 ELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKS 1519
Query: 369 --EFQSTLTKSNEV-------FATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDM 419
+ +S ++ N+ A ++E DK +M + + + + E+ AL +
Sbjct: 1520 LADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGL 1579
Query: 420 IEEKALRAKE--------------------------------YECFVMKIGRLENLCRAL 447
E+K KE YE + R++++ A+
Sbjct: 1580 TEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAV 1639
Query: 448 QEERNELHKKIRDAEISEKDDQSQHNSDEE 477
++E+ EL+ K+R E ++K+ + Q E+
Sbjct: 1640 RQEKQELYGKLRSTEANKKETEKQLQEAEQ 1669
Score = 52.0 bits (123), Expect = 2e-06
Identities = 95/448 (21%), Positives = 179/448 (39%), Gaps = 73/448 (16%)
Query: 130 EQKLEK--KILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRT--------- 178
++KLE+ + L G + +LL Q L E++ L ++ ++ EH T
Sbjct: 258 QRKLEEHEESLVGRAQVVDLLQQELT---AAEQRNQILSQQLQQMEAEHNTLRNTVETER 314
Query: 179 EQKKLKLLQKKQVQI----------QKEKDQLQGEHSRAILARSKLESLCRELQRHNKTL 228
E+ K+ LL+K ++++ Q+E L + +A A+++LES L++ +K
Sbjct: 315 EESKI-LLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKA- 372
Query: 229 KEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQ 288
E EEK I S Q T ++Q + ++N KL Q+ E A + I Q
Sbjct: 373 ---------EMEEKTSHILS-LQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQ 422
Query: 289 YELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKV 348
E +LQQK + + +++ E + + N+ + + +
Sbjct: 423 LE------------DQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENI 470
Query: 349 LKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKAR 408
Q+ V++ E + L S+ K E +K + ++ LE T +A
Sbjct: 471 ASLQKRVVE---------LENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEAD 521
Query: 409 FENCNKALLDMIEEKALRAKE------YECFVMKIGRLENLCRALQEERNE---LHKKIR 459
E +++D+ +++ A+E F K L L ++E + E L +++
Sbjct: 522 REVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQ 581
Query: 460 DAEISEKDDQ---SQHNSDEEPESNVSVDQEIDAEEVNSVQTAVKNLATAFMIIHHPE-S 515
E D + + E E + ++ E+ + N ++ + + S
Sbjct: 582 GKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQAS 641
Query: 516 TPHQSKETQPEIGSSQESADAALKEPEQ 543
T HQS+ T EI S A LK +Q
Sbjct: 642 TEHQSR-TSEEI--SLNDAGVELKSTKQ 666
Score = 52.0 bits (123), Expect = 2e-06
Identities = 107/576 (18%), Positives = 224/576 (38%), Gaps = 89/576 (15%)
Query: 55 ISEELNRQLEDIINTYGS---AASTAGKEGSARASEQPENAESPDNEDGDCEETTEEAGR 111
+ EE+N + + II+ A A E + ++ + E+ +++ + EE +
Sbjct: 2373 LHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENK 2432
Query: 112 EPVASGEPPTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKL----QTPEEKFDFLFK 167
+ V KE +K L K + L + +++ Q EE+ +
Sbjct: 2433 KAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIIL 2492
Query: 168 KYAELLDEHRTEQKKLKL-----------LQKKQVQIQKEKDQLQGEHSRAILARSKLES 216
+ +L+ E E KLK L + ++ E Q + + ++ I + +
Sbjct: 2493 EKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQK 2552
Query: 217 LCRELQ-RHNKTLK------EEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNM 269
E+Q + NK L+ EE L+ + E E + + Q D+ +IE
Sbjct: 2553 QLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSIS 2612
Query: 270 KLCQENTELAEK--LKSIIDQYELREEHLDKIF--------KHRELQQKLVDAKLEQAQE 319
+L ++ T L E+ L Q +++EE + ++ + EL+++LV + E A++
Sbjct: 2613 QLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKK 2672
Query: 320 MMKEAEERHKREKEYLLNQAAEWKLQAKVLKE---------------------QETVLQA 358
+ E E++ K+E ++L + A + + + +E + L A
Sbjct: 2673 V-GEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTA 2731
Query: 359 QLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKL--------EKDTATWKARF- 409
Q+ + Q++ +NE K++ D + K++ +L E+D + F
Sbjct: 2732 QIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFS 2791
Query: 410 ------------ENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKK 457
E N+ LL E+ + + E ++ +LQ ER+ L +
Sbjct: 2792 MNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNE 2851
Query: 458 IRDAEISEKDDQSQHNSDEEPESNVSVDQEIDAEEVNSVQT-------AVKNLATAFMII 510
+ E K ++ + S +P ++ + Q + + ++S+Q +KNL ++ I
Sbjct: 2852 L---EKFRKSEEGKQRSAAQPSTSPAEVQSL-KKAMSSLQNDRDRLLKELKNLQQQYLQI 2907
Query: 511 HHPESTPHQSKETQPEIGSSQESADAALKEPEQPPL 546
+ + H K E ++ +E Q L
Sbjct: 2908 NQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENL 2943
Score = 48.9 bits (115), Expect = 2e-05
Identities = 86/426 (20%), Positives = 172/426 (40%), Gaps = 40/426 (9%)
Query: 80 EGSARASEQPENAESPDNEDGDCEETTEEAGREPVASGEPPTVKEPVSNKEQKLEKKILK 139
E R EQ E E E + +E + RE V ++E + + L KK
Sbjct: 2121 EDLERRLEQAE--EKHLKEKKNMQEKLDALRREKVH------LEETIGEIQVTLNKK--- 2169
Query: 140 GLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQ 199
KE L +NL+ T F + D E KK + +Q ++E+ +
Sbjct: 2170 --DKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIR 2227
Query: 200 LQGEHSRAILARSKLESLCRELQRHNKTLKEEALQ----RAREEEEKRKEITSHFQSTLT 255
L+ ++ + + + S+ E + N + E Q +A+ E + ++++ Q
Sbjct: 2228 LKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENK 2287
Query: 256 DIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRE-----LQQKLV 310
++ Q+E+ E +L +LKS+ DQ L+K + + ++Q+
Sbjct: 2288 ELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEA 2347
Query: 311 DAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQ--AKVLKEQETVLQAQLT----LYS 364
D + + E + + RE L++ K Q +L +E +Q + +
Sbjct: 2348 DIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHD 2407
Query: 365 GRFEEFQSTLTKSNEVFATFKQE----MDKTTKKM---KKLEKDTATWKARFENCNKALL 417
+E ++ L++ E ++E +DKT + M K ++K+ KA+ ++ K++
Sbjct: 2408 KEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMS 2467
Query: 418 DMIEEKALRAKEY----ECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHN 473
+ ++ +Y E + I + L + E N+L ++IR S DD + N
Sbjct: 2468 SLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLR-SHMDDLNSEN 2526
Query: 474 SDEEPE 479
+ + E
Sbjct: 2527 AKLDAE 2532
Score = 48.1 bits (113), Expect = 3e-05
Identities = 68/342 (19%), Positives = 136/342 (39%), Gaps = 53/342 (15%)
Query: 229 KEEALQRAREE-EEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIID 287
K+EALQ R+ + K K++ H ++ LT + IE+ + + + E+L
Sbjct: 78 KDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDK 137
Query: 288 QYELREEHLDKIFKHR---------ELQQKLVDAKLEQAQEMMKEAEE-----RHKREKE 333
E ++KI KH+ LQ +L A+ EQ + E EE + +EKE
Sbjct: 138 SSTEEEMEIEKI-KHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKE 196
Query: 334 YLLN------------QAAEWKLQAKVLK-------------------EQETVLQAQLTL 362
++ QAA+ ++ K + + ET +Q +L +
Sbjct: 197 EFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRV 256
Query: 363 YSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEE 422
+ EE + +L +V +QE+ ++ + L + +A + EE
Sbjct: 257 LQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREE 316
Query: 423 KALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEPESNV 482
+ ++ E +++ + LQEE + L ++ A ++ + +S++++ E+
Sbjct: 317 SKILLEKME---LEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKH--- 370
Query: 483 SVDQEIDAEEVNSVQTAVKNLATAFMIIHHPESTPHQSKETQ 524
+ E + S+Q + L +A + S Q K Q
Sbjct: 371 KAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQ 412
Score = 45.4 bits (106), Expect = 2e-04
Identities = 83/406 (20%), Positives = 166/406 (40%), Gaps = 79/406 (19%)
Query: 141 LGKEANLLMQNLNKLQTPEEKFDFLFKKYAEL---LDEHRTEQKKLKLLQKKQVQ----- 192
LG E L + LN L EE ++ E+ L ++ E + K+++Q
Sbjct: 924 LGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDL 983
Query: 193 IQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQS 252
++KE +Q + + A++ R +L L+ LK+E+ + E +R E+ ++
Sbjct: 984 LKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKEN 1043
Query: 253 TLTDIQGQIEQQSERNM-KLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVD 311
++ SE+ + CQ E+ LK I + E+ +H+ K +L++KL
Sbjct: 1044 ---------KEYSEKCVTSKCQ---EIEIYLKQTISEKEVELQHIRK-----DLEEKL-- 1084
Query: 312 AKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQ 371
A EQ Q ++K+ + L ++ + L + E + ++Q +T + +
Sbjct: 1085 AAEEQFQALVKQMNQT-------LQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDS 1137
Query: 372 STLTKSNEVFAT--------FKQEMDKTTKKMKKLEKDTATWKARFENC---NKALLDMI 420
L K V + +K E++ +K+ LEK+ + + + KA+L
Sbjct: 1138 VALVKETVVISPPCTGSSEHWKPELE---EKILALEKEKEQLQKKLQEALTSRKAILKKA 1194
Query: 421 EEKALRAKE------------YECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDD 468
+EK +E E F + EN+ L++ + ++ + I D ++ D
Sbjct: 1195 QEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESI-DGKLPSTDQ 1253
Query: 469 Q-----------------SQHNSDEEPESNVSVDQEIDAEEVNSVQ 497
Q QH++ ESN+ D +E+ +++Q
Sbjct: 1254 QESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQ 1299
Score = 44.7 bits (104), Expect = 3e-04
Identities = 75/370 (20%), Positives = 154/370 (41%), Gaps = 73/370 (19%)
Query: 186 LQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKE 245
L++K + ++KEK+QLQ + A+ +R + +E +RH REE +++K+
Sbjct: 1162 LEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERH-----------LREELKQQKD 1210
Query: 246 ITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHREL 305
+ Q Q ++QS +EN + ++L+ + Q ++RE +D +
Sbjct: 1211 DYNRLQE-------QFDEQS-------KENENIGDQLRQL--QIQVRES-IDGKLPSTDQ 1253
Query: 306 QQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAK------------VLKEQE 353
Q+ + +E + +A E+H + N +W ++ +K Q
Sbjct: 1254 QESC--SSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQL 1311
Query: 354 TVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCN 413
++A+ + S LTK +E +++++K +++ L+ T + +A
Sbjct: 1312 KEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLK--TVSHEAE----- 1364
Query: 414 KALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHN 473
+ ++L+ K E ++I LE+L R LQ + +EL K IS+K++ +
Sbjct: 1365 ------VHAESLQQK-LESSQLQIAGLEHL-RELQPKLDELQKL-----ISKKEEDVSYL 1411
Query: 474 SDEEPESNVSVDQEIDAEEVNSVQTAVKNLATAFMIIHHPESTPHQSKETQPEIGSSQES 533
S + E + + +QT + +H Q+KE I Q
Sbjct: 1412 SGQLSEKEAA---------LTKIQTEIIEQEDLIKALH--TQLEMQAKEHDERIKQLQVE 1460
Query: 534 ADAALKEPEQ 543
++PE+
Sbjct: 1461 LCEMKQKPEE 1470
Score = 40.4 bits (93), Expect = 0.005
Identities = 121/595 (20%), Positives = 237/595 (39%), Gaps = 103/595 (17%)
Query: 1 MEANHSEQLSAERQSTPPGDSSSLPSHNGLE-KEDGQDSPTPVQPPEKEASVHPDISEEL 59
+ A EQ S E QS + S + G+E K QD + H D E L
Sbjct: 632 LPAVEKEQASTEHQSRTSEEISL--NDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERL 689
Query: 60 NRQLEDIINTYGSAASTAGKEGSARASEQP-------ENAESPDNEDGDCEETTEEAGRE 112
Q+ ++ + A K +A E E ++ DN +EE R+
Sbjct: 690 KSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEE--RD 747
Query: 113 PVASGEPPTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAEL 172
+ S VKE E + + K L+ EA + + QT + + L ++ L
Sbjct: 748 QLLS----QVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHD--NLLTEQIHSL 801
Query: 173 LDEHRTEQKKLKLLQKKQVQIQKE-----------KDQLQGEHSRAILARSKLESLCREL 221
E +++ K+++LQ + +Q + + QLQ + S + ++ + ++
Sbjct: 802 SIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKV 861
Query: 222 QRHNKTLKEEALQRAREEE---EKRKEITSHFQSTLTDIQGQIEQQS----ERNMKLCQE 274
+ ++ L ++ L+ + ++ EK++++ + Q T+ + Q+ + S E+ ++L +E
Sbjct: 862 EELSQALSQKELEITKMDQLLLEKKRDVET-LQQTIEEKDQQVTEISFSMTEKMVQLNEE 920
Query: 275 NTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQAQE--------------- 319
L ++K++ +Q L + +AK EQ +E
Sbjct: 921 KFSLGVEIKTLKEQLNLLS--------------RAEEAKKEQVEEDNEVSSGLKQNYDEM 966
Query: 320 ----MMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLT 375
+ + E +H+ + N+ + KLQA ++ +E + + R EE + L
Sbjct: 967 SPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRV------SRLEEELANLK 1020
Query: 376 KSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIE---EKALRAKEYEC 432
+ K+E+ + + ++E+D K E C + IE ++ + KE E
Sbjct: 1021 DES------KKEIPLSETERGEVEEDKEN-KEYSEKCVTSKCQEIEIYLKQTISEKEVEL 1073
Query: 433 FVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEPESNVSVDQEI---- 488
++ E L A +E+ L K++ + +K +Q E E+ + + I
Sbjct: 1074 QHIRKDLEEKL--AAEEQFQALVKQMNQT-LQDKTNQIDLLQAEISENQAIIQKLITSNT 1130
Query: 489 DAEEVNSVQTAVKNLATAFMIIHHPESTPHQSKETQPEIGSSQESADAALKEPEQ 543
DA + +SV L ++I P S+ +PE+ +E A KE EQ
Sbjct: 1131 DASDGDSVA-----LVKETVVISPP--CTGSSEHWKPEL---EEKILALEKEKEQ 1175
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 75.5 bits (184), Expect = 2e-13
Identities = 101/483 (20%), Positives = 206/483 (42%), Gaps = 34/483 (7%)
Query: 111 REPVASGEPPTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYA 170
+E + +GE + + + KLE+++ K A L + K ++ + D +K
Sbjct: 920 QETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVI 979
Query: 171 ELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLC----RELQRHNK 226
EL R + ++ +++ +++KE L+ + + S+L+ + EL++
Sbjct: 980 ELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTN 1039
Query: 227 TLKE-EALQRAREEE-----EKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAE 280
+KE E LQ + E E +KR+ + + Q+ +++ + Q E L + L E
Sbjct: 1040 AVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEE 1099
Query: 281 KLKSIID-QYELRE---EHLDKIFKHRELQQKLVDAKLEQAQEM-------MKEAEERHK 329
K +I D ELRE E DK + E+ Q L + E Q M E R +
Sbjct: 1100 KYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGE 1159
Query: 330 REKEYLLNQAAEWK--LQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQE 387
E++ + + K L+ K +Q L +L + E + + ++ + + K+E
Sbjct: 1160 MEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKE 1219
Query: 388 MDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRAL 447
+++T ++MK++E + K +D+ +E L ++ + ++ +
Sbjct: 1220 IERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQA 1279
Query: 448 QEERNELHKKIRDAE--ISEKDDQSQHNSDEEPESNVSVDQEIDAE---EVNSVQTAVKN 502
Q E L ++ D + EKD H ++E S V + ++A E+ + V++
Sbjct: 1280 QREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVR-EAHLEARMQAEIKKLSAEVES 1338
Query: 503 LATAFMIIHHPESTPHQSKETQPEIGS-SQESADAALKEPEQPPLIPSRDSESPLPPLTP 561
L A+ H E HQ + +I + SQ+S+ L E + + +++ + L
Sbjct: 1339 LKEAY----HMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQ 1394
Query: 562 QAE 564
Q +
Sbjct: 1395 QVQ 1397
Score = 52.0 bits (123), Expect = 2e-06
Identities = 89/381 (23%), Positives = 164/381 (43%), Gaps = 60/381 (15%)
Query: 145 ANLLMQNLNKLQTPEE--KFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQG 202
AN L Q+L +E K L + +L E K + Q +KE+ +L
Sbjct: 582 ANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVT 641
Query: 203 --EHSRAILARSKLESLCRELQRHNKT-----LKEEALQRAREEEEKRKEITSHFQSTLT 255
E R L + + E+ ++ ++T ++EE L++A + E+T LT
Sbjct: 642 GIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLT 701
Query: 256 DIQGQIEQQ-------SERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQK 308
++ Q+E++ + +N +L QE E EK++S+ + + EH +KI E +K
Sbjct: 702 -LEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSL--ETNINTEH-EKICLAFEKAKK 757
Query: 309 LVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFE 368
+ LEQ +EM K+ E R + L + ++K Q K + ++LQ + E
Sbjct: 758 I---HLEQHKEMEKQIE----RLEAQLEKKDQQFKEQEKTM----SMLQQDIICKQHHLE 806
Query: 369 EFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAK 428
LT+S K EM K + ++KD A KAL + + E+ ++ +
Sbjct: 807 SLDRLLTES-------KGEMKK-----ENMKKDEAL---------KALQNQVSEETIKVR 845
Query: 429 EYECFVMKIGRLENLCRALQEERN------ELHKKIRDAEISEKDDQ-SQHNSDEEPESN 481
+ + ++I + E + Q E N +L KK + +K+ + H+ E E N
Sbjct: 846 QLDS-ALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQN 904
Query: 482 VSVDQEIDAEEVNSVQTAVKN 502
V + + ++ Q ++N
Sbjct: 905 VILQHTLQQQQQMLQQETIRN 925
Score = 48.1 bits (113), Expect = 3e-05
Identities = 65/334 (19%), Positives = 131/334 (39%), Gaps = 48/334 (14%)
Query: 211 RSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMK 270
R K+ S + + K+L+E+ L + R++ + I ++ Q +
Sbjct: 217 RDKMFSSSAPVDQEIKSLREK-LNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSM 275
Query: 271 L--CQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERH 328
L Q+ L+ I E DK+ + E KLEQ+Q+M+ E E+
Sbjct: 276 LESAQQQAASVPILEEQIINLEAEVSAQDKVLREAE-------NKLEQSQKMVIEKEQSL 328
Query: 329 KREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEM 388
+ KE + KL+ +L++ + +A+ + L + E+ F+Q
Sbjct: 329 QESKEECI------KLKVDLLEQTKQGKRAE--------RQRNEALYNAEELSKAFQQYK 374
Query: 389 DKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQ 448
K +K++K++ + + NC K + E L E E K+ R L+
Sbjct: 375 KKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKL-------RQLK 427
Query: 449 EERNELHKKIRDAEISEKDDQSQHNSDEEPESNVSVDQEIDAEEVNSVQTAVKNLATAFM 508
EE N +K+R + + +Q E +S + ++ E++ ++
Sbjct: 428 EENNNGKEKLRIMAVKNSEVMAQ--LTESRQSILKLESELENKD---------------E 470
Query: 509 IIHHPESTPHQSKETQPEIGSSQESADAALKEPE 542
I+ S ++++E + + + E D +E E
Sbjct: 471 ILRDKFSLMNENRELKVRVAAQNERLDLCQQEIE 504
>gi|150010552 FK506 binding protein 15, 133kDa [Homo sapiens]
Length = 1219
Score = 75.5 bits (184), Expect = 2e-13
Identities = 93/481 (19%), Positives = 204/481 (42%), Gaps = 51/481 (10%)
Query: 143 KEANLLMQNLNK-LQTPEEKFDFLF----KKYAELLDEHRTEQKKLKLLQKKQVQIQKEK 197
+++NL+M+ N LQT E ++ A++ +E ++ LQ K QK++
Sbjct: 607 EQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKE 666
Query: 198 DQLQGEHSRAI----LARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEI---TSHF 250
+LQ + + ++ L R +L + +L +T E+A + + E++ RK++ +
Sbjct: 667 TELQMQLTESLKETDLLRGQLTKVQAKLSELQET-SEQAQSKFKSEKQNRKQLELKVTSL 725
Query: 251 QSTLTDIQGQIEQQ----SERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHREL- 305
+ LTD++ + E SER K QE ++ E++ I Y+ + L ++ K +
Sbjct: 726 EEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVS 785
Query: 306 -------QQKLVDAKLE-----QAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQE 353
Q LV A+L+ + + ++ A++ H ++ + + Q ++ + L+E+
Sbjct: 786 TDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKC 845
Query: 354 TVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCN 413
LQAQ+T + + E+ L K+ + + ++K+KK+ F++
Sbjct: 846 LALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQV------FQSLR 899
Query: 414 KALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHN 473
+ + E++ + +M ++ L + L ++ E + + E + +++ +
Sbjct: 900 R---EFELEESYNGRTILGTIMNTIKMVTL-QLLNQQEQEKEESSSEEEEEKAEERPRRP 955
Query: 474 SDEEPESNVSVDQEIDAEEVNSVQTAVKNLATAFMIIHHPESTPHQSKETQPEIGSSQES 533
S E+ S S + V + + P S++ G S+
Sbjct: 956 SQEQSASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQDGHRRKGDSEAE 1015
Query: 534 ADAALKEPEQPPLI-----------PSRDSESPLPPLTPQAEAEGGSDAEPPSKASNSPA 582
A + +K+ PP + P+ PL P++ +E E A P + ++P+
Sbjct: 1016 ALSEIKDGSLPPELSCIPSHRVLGPPTSIPPEPLGPVSMDSECEESLAASPMAAKPDNPS 1075
Query: 583 G 583
G
Sbjct: 1076 G 1076
Score = 70.5 bits (171), Expect = 5e-12
Identities = 151/772 (19%), Positives = 283/772 (36%), Gaps = 171/772 (22%)
Query: 36 QDSPTPVQPPEKEASVHPDISEELNRQLEDIINTYGSAASTAGKEGSARASEQPENAESP 95
Q PV P + S+HP + + S G + + A Q + +S
Sbjct: 397 QGGGQPVVTPSVQPSLHPA------HPALPQMTSQAPQPSVTGLQAPSAALMQVSSLDSH 450
Query: 96 DNEDGDCEETTEEAGREPVASGEPPTVKEPVSNKEQKLEKKI-----LKGLGKEANLLMQ 150
G+ + AG + A + V + + +G G A+ LM
Sbjct: 451 SAVSGNAQSFQPYAGMQAYAYPQASAVTSQLQPVRPLYPAPLSQPPHFQGSGDMASFLMT 510
Query: 151 NLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILA 210
+ T + K A+ +D T+ ++L Q + + +
Sbjct: 511 EARQHNT---EIRMAVSKVADKMDHLMTKVEEL--------QKHSAGNSMLIPSMSVTME 559
Query: 211 RSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERN-- 268
S + S + + + N+ LK+E L+++ EE+ +I+ + ++ +RN
Sbjct: 560 TSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNS 619
Query: 269 MKLCQENTELAEKLKSIIDQYELREE---------HLD-KIFKHR----ELQQKL----- 309
++ ENT+ A L + ++ ++ EE HL K+ H+ ELQ +L
Sbjct: 620 LQTATENTQ-ARVLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLK 678
Query: 310 -----------VDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQA 358
V AKL + QE ++A+ + K EK+ + +L+ L+E+ T L+
Sbjct: 679 ETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQ----NRKQLELKVTSLEEELTDLRV 734
Query: 359 QLTLYSGRFEEFQSTLTKS--------NEVFATFKQEMDKTTKKMKKLEKDT-------- 402
+ E + + +E+ ++++E+DK + +KK T
Sbjct: 735 EKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQL 794
Query: 403 --------ATWKARFENCNKALLDMIEEKALRAKEYEC-----FVMKIGRLENLCRALQE 449
W+A+ E+ LL +++ L+ + C + K+ +L+ C ALQ
Sbjct: 795 SLVQAELQTQWEAKCEH----LLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQA 850
Query: 450 ERNELHKK----IRDAEISEKDDQSQHNSDEEPESNV---------SVDQEIDAEE---- 492
+ L K+ I++ E ++ + +P V S+ +E + EE
Sbjct: 851 QITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRREFELEESYNG 910
Query: 493 ---VNSVQTAVKNLATAFMIIHHPESTPHQSKETQ------PEIGSSQESADAALKEPEQ 543
+ ++ +K + + E S+E + P S ++SA A+ +P+
Sbjct: 911 RTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQA 970
Query: 544 P--------PLIPSRDSESPLPPLTPQA--------EAEGGSDAE--------------- 572
P P++PS PL PQA +G S+AE
Sbjct: 971 PLNRERPESPMVPSEQVVEEAVPLPPQALTTSQDGHRRKGDSEAEALSEIKDGSLPPELS 1030
Query: 573 ---------PPSKASNSPAG-LGAETQCE----GLPVGAQADQASWKPEAEASGQAPQAP 618
PP+ P G + +++CE P+ A+ D S K AP P
Sbjct: 1031 CIPSHRVLGPPTSIPPEPLGPVSMDSECEESLAASPMAAKPDNPSGK--VCVREVAPDGP 1088
Query: 619 TEASLQKMEADVPAPACAAEEHVAAMVPACEPSRQPPRAAAEELPVGASAGP 670
LQ+ + + E A+ P QPP+ ++ V +S GP
Sbjct: 1089 ----LQESSTRLSLTSDPEEGDPLALGPESPGEPQPPQLKKDD--VTSSTGP 1134
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 74.3 bits (181), Expect = 3e-13
Identities = 88/413 (21%), Positives = 192/413 (46%), Gaps = 47/413 (11%)
Query: 123 KEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKK 182
KE + NK+ K + + + G +A + + L E K + L KK L ++ R ++K+
Sbjct: 534 KETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQ 593
Query: 183 LKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEK 242
+ L+++ LQ + + A + LE E +R + LKE QR R+E EK
Sbjct: 594 MSSLKERV-------KSLQADTTNTDTALTTLEEALAEKERTIERLKE---QRDRDEREK 643
Query: 243 RKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKH 302
++EI +++ L D++ ++ L Q +L+EK S++D E K
Sbjct: 644 QEEI-DNYKKDLKDLKEKV--------SLLQ--GDLSEKEASLLDLKEHASSLASSGLK- 691
Query: 303 RELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTL 362
++ + K ++ LEQ +E + E + K+ E L A ++ ++ L+ ++T
Sbjct: 692 KDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQH-----LEREITR 746
Query: 363 YSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEE 422
Y + Q+ + + E+ + E + KK+ +LE+ + ++ NK + ++ +
Sbjct: 747 YKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELER-------QVKDQNKKVANLKHK 799
Query: 423 KALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEPES-N 481
+ + K K ++ R ++ N+ ++++D+ + +KDD+ + + ES
Sbjct: 800 EQVEKK-------KSAQMLEEARRREDNLNDSSQQLQDS-LRKKDDRIEELEEALRESVQ 851
Query: 482 VSVDQE-IDAEEVNSVQTAVKNLATAFMIIHHPESTPHQSKETQPEIGSSQES 533
++ ++E + A+E ++ A K + M + E + + + ++ S+Q+S
Sbjct: 852 ITAEREMVLAQEESARTNAEKQVEELLMAM---EKVKQELESMKAKLSSTQQS 901
Score = 61.2 bits (147), Expect = 3e-09
Identities = 82/413 (19%), Positives = 176/413 (42%), Gaps = 44/413 (10%)
Query: 143 KEANLLMQNLNKLQTPEEKFDFLFKK-YAELLDEHRTEQKKLKLLQKK----QVQIQKEK 197
++ N L Q + +T E L ++ + L EH + K+L LL+K +++I+ +K
Sbjct: 240 RDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQK 299
Query: 198 DQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDI 257
L ++ L LQ + K A EE+ +R + + + +
Sbjct: 300 QTLNARDE-------SIKKLLEMLQSKGLSAK------ATEEDHERTRRLAEAEMHVHHL 346
Query: 258 QGQIEQQSERNMKLCQE------NTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVD 311
+ +EQ+ + N L +E N + K K++ E+++ + +++ L D
Sbjct: 347 ESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISS------MERGLRD 400
Query: 312 AKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQ 371
LE+ +M+K E+E + Q ++ +K +K + L+ +L+ ++EE +
Sbjct: 401 --LEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELK 458
Query: 372 STLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYE 431
KQE+ + ++ L+ T +F + +K +++++E +L AKE
Sbjct: 459 KKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSD-SKQHIEVLKE-SLTAKEQR 516
Query: 432 CFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEPESNVSVDQ-EIDA 490
+++ ++ L L+E+ L+KK + + D ++ + E + D ++
Sbjct: 517 AAILQT-EVDALRLRLEEKETMLNKKTKQIQ-----DMAEEKGTQAGEIHDLKDMLDVKE 570
Query: 491 EEVNSVQTAVKNLATAFMIIHHPESTPHQSKETQPEIGSSQESADAALKEPEQ 543
+VN +Q ++NL + E KE + + + D AL E+
Sbjct: 571 RKVNVLQKKIENLQEQ---LRDKEKQMSSLKERVKSLQADTTNTDTALTTLEE 620
Score = 55.8 bits (133), Expect = 1e-07
Identities = 77/376 (20%), Positives = 164/376 (43%), Gaps = 25/376 (6%)
Query: 46 EKEASVHPDISEELNRQLEDIINTYGSAASTAGKEGSARASEQPENAESPDNEDGDCEET 105
EK + + D+SE+ L+ + + S+ +++G + +R E E E
Sbjct: 659 EKVSLLQGDLSEKEASLLD--LKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQ 716
Query: 106 TEEAGREPVASGEPPTVKEPVSNKEQKLE--KKILKGLGKEANLLMQNLNKLQTPEEKFD 163
++A + + P + + + + E+++ K E + L++ L +++ + D
Sbjct: 717 LKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKD 776
Query: 164 FLFKKYAELLDEHRTEQKKL-KLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQ 222
KK AEL + + + KK+ L K+QV+ +K L+ R + L L+
Sbjct: 777 ---KKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLR 833
Query: 223 RHNKTLKE--EALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAE 280
+ + ++E EAL+ + + +R+ + + +S T+ + Q+E+ K+ QE +
Sbjct: 834 KKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKA 893
Query: 281 KLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAA 340
KL S +E HL + R ++K ++ LE QE + A L ++
Sbjct: 894 KLSSTQQSLAEKETHLTNL---RAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSS 950
Query: 341 EWKLQAKV--LKEQETVL--------QAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDK 390
+ K Q +V LK ++ L Q ++ L + +E+ + SN+ K D+
Sbjct: 951 KKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQ--TNHKPSPDQ 1008
Query: 391 TTKKMKKLEKDTATWK 406
+ + +L+++ + K
Sbjct: 1009 IIQPLLELDQNRSKLK 1024
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 74.3 bits (181), Expect = 3e-13
Identities = 88/413 (21%), Positives = 192/413 (46%), Gaps = 47/413 (11%)
Query: 123 KEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKK 182
KE + NK+ K + + + G +A + + L E K + L KK L ++ R ++K+
Sbjct: 506 KETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQ 565
Query: 183 LKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEK 242
+ L+++ LQ + + A + LE E +R + LKE QR R+E EK
Sbjct: 566 MSSLKERV-------KSLQADTTNTDTALTTLEEALAEKERTIERLKE---QRDRDEREK 615
Query: 243 RKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKH 302
++EI +++ L D++ ++ L Q +L+EK S++D E K
Sbjct: 616 QEEI-DNYKKDLKDLKEKV--------SLLQ--GDLSEKEASLLDLKEHASSLASSGLK- 663
Query: 303 RELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTL 362
++ + K ++ LEQ +E + E + K+ E L A ++ ++ L+ ++T
Sbjct: 664 KDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQH-----LEREITR 718
Query: 363 YSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEE 422
Y + Q+ + + E+ + E + KK+ +LE+ + ++ NK + ++ +
Sbjct: 719 YKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELER-------QVKDQNKKVANLKHK 771
Query: 423 KALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEPES-N 481
+ + K K ++ R ++ N+ ++++D+ + +KDD+ + + ES
Sbjct: 772 EQVEKK-------KSAQMLEEARRREDNLNDSSQQLQDS-LRKKDDRIEELEEALRESVQ 823
Query: 482 VSVDQE-IDAEEVNSVQTAVKNLATAFMIIHHPESTPHQSKETQPEIGSSQES 533
++ ++E + A+E ++ A K + M + E + + + ++ S+Q+S
Sbjct: 824 ITAEREMVLAQEESARTNAEKQVEELLMAM---EKVKQELESMKAKLSSTQQS 873
Score = 55.8 bits (133), Expect = 1e-07
Identities = 77/376 (20%), Positives = 164/376 (43%), Gaps = 25/376 (6%)
Query: 46 EKEASVHPDISEELNRQLEDIINTYGSAASTAGKEGSARASEQPENAESPDNEDGDCEET 105
EK + + D+SE+ L+ + + S+ +++G + +R E E E
Sbjct: 631 EKVSLLQGDLSEKEASLLD--LKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQ 688
Query: 106 TEEAGREPVASGEPPTVKEPVSNKEQKLE--KKILKGLGKEANLLMQNLNKLQTPEEKFD 163
++A + + P + + + + E+++ K E + L++ L +++ + D
Sbjct: 689 LKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKD 748
Query: 164 FLFKKYAELLDEHRTEQKKL-KLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQ 222
KK AEL + + + KK+ L K+QV+ +K L+ R + L L+
Sbjct: 749 ---KKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLR 805
Query: 223 RHNKTLKE--EALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAE 280
+ + ++E EAL+ + + +R+ + + +S T+ + Q+E+ K+ QE +
Sbjct: 806 KKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKA 865
Query: 281 KLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAA 340
KL S +E HL + R ++K ++ LE QE + A L ++
Sbjct: 866 KLSSTQQSLAEKETHLTNL---RAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSS 922
Query: 341 EWKLQAKV--LKEQETVL--------QAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDK 390
+ K Q +V LK ++ L Q ++ L + +E+ + SN+ K D+
Sbjct: 923 KKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQ--TNHKPSPDQ 980
Query: 391 TTKKMKKLEKDTATWK 406
+ + +L+++ + K
Sbjct: 981 IIQPLLELDQNRSKLK 996
Score = 52.0 bits (123), Expect = 2e-06
Identities = 73/368 (19%), Positives = 150/368 (40%), Gaps = 53/368 (14%)
Query: 143 KEANLLMQNLNKLQTPEEKFDFLFKK-YAELLDEHRTEQKKLKLLQKK----QVQIQKEK 197
++ N L Q + +T E L ++ + L EH + K+L LL+K +++I+ +K
Sbjct: 240 RDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQK 299
Query: 198 DQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDI 257
L ++ L LQ + K A EE+ +R + + + +
Sbjct: 300 QTLNARDE-------SIKKLLEMLQSKGLSAK------ATEEDHERTRRLAEAEMHVHHL 346
Query: 258 QGQIEQQSERNMKLCQE------NTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVD 311
+ +EQ+ + N L +E N + K K++ E+++ + +++ L D
Sbjct: 347 ESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISS------MERGLRD 400
Query: 312 AKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQ 371
LE+ +M+K E+E + Q ++ +K +K + ++ +L+ Q
Sbjct: 401 --LEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQ 458
Query: 372 STLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFE--------------NCNKALL 417
+ L F+ KQ ++ + + E+ A + + K +
Sbjct: 459 TKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQ 518
Query: 418 DMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEE 477
DM EEK +A E I L+++ + + N L KKI + + +D + Q +S +E
Sbjct: 519 DMAEEKGTQAGE-------IHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKE 571
Query: 478 PESNVSVD 485
++ D
Sbjct: 572 RVKSLQAD 579
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 73.6 bits (179), Expect = 6e-13
Identities = 78/366 (21%), Positives = 167/366 (45%), Gaps = 43/366 (11%)
Query: 129 KEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQK 188
KE+ + +K L +E L +N++KL T E+K L + + + LD+ + E+ K+ L K
Sbjct: 970 KEKHATENKVKNLSEEMTALEENISKL-TKEKKS--LQEAHQQTLDDLQVEEDKVNGLIK 1026
Query: 189 KQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITS 248
+++++ D L+G + R+ LE R+L+ K + +E++ ++++ +E
Sbjct: 1027 INAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLK-MSQESIMDLENDKQQIEEKLK 1085
Query: 249 HFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQK 308
+ L+ +Q +I+ + +++ ++ EL +++ + ++ E KI E Q+
Sbjct: 1086 KKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKI----EKQRS 1141
Query: 309 LVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFE 368
+ +LE+ E ++EA + E + AE++ + L +E LQ + T + R +
Sbjct: 1142 DLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDL--EEATLQHEATAATLRKK 1199
Query: 369 EFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAK 428
+ S A +++D + +KLEK+ + K ++ A
Sbjct: 1200 QADSV--------AELGEQIDNLQRVKQKLEKEKSELKMEIDD--------------MAS 1237
Query: 429 EYECFVMKIGRLENLCRALQEERNELHKK-------IRDAEISEKDDQSQH----NSDEE 477
E +E CR ++++ +E+ K I D + + Q+Q+ + EE
Sbjct: 1238 NIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEE 1297
Query: 478 PESNVS 483
ES +S
Sbjct: 1298 KESLIS 1303
Score = 59.7 bits (143), Expect = 9e-09
Identities = 99/455 (21%), Positives = 180/455 (39%), Gaps = 64/455 (14%)
Query: 79 KEGSARASEQPENAESPDNEDGDCEETTEEAGREPVASGEPPTVKEPVSNKEQKLEKKIL 138
KE AR E E E+ E+ + RE E ++ + ++ KK
Sbjct: 1113 KELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKK-- 1170
Query: 139 KGLGKEANL--LMQNLNKLQTPEEKFDFLFKK-----YAELLDEHRTEQKKLKLLQKKQV 191
+EA + ++L + E +K AEL ++ Q+ + L+K++
Sbjct: 1171 ----REAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKS 1226
Query: 192 QIQKEKDQLQGEHSRAILARSKLESLCRELQR----------------HNKTLKEEALQR 235
+++ E D + ++S +E CR ++ H+ +++ LQ
Sbjct: 1227 ELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQT 1286
Query: 236 AREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTE----LAEKLKSIIDQYEL 291
E R E S LT + + QQ E + +E T+ +A L+S +L
Sbjct: 1287 QNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDL 1346
Query: 292 -REEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLK 350
RE++ ++ ELQ+ L A E AQ K + +R +E + A+ KL ++ +
Sbjct: 1347 LREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEEL---EEAKKKLAQRLQE 1403
Query: 351 EQETVLQAQLTLYS---------GRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKD 401
+E A S G E+ L +S+ AT KK + +K
Sbjct: 1404 AEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLD-------KKQRNFDKV 1456
Query: 402 TATWKARFENCNKALLDMIEEKALRAKEYECFVMK------IGRLENLCRA---LQEERN 452
A WK + + L +K R+ E F M+ + +LE L R LQEE +
Sbjct: 1457 LAEWKQKLDESQAEL--EAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEIS 1514
Query: 453 ELHKKIRDAEISEKDDQSQHNSDEEPESNVSVDQE 487
+L ++I + + ++ + E+ +S++ V E
Sbjct: 1515 DLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALE 1549
Score = 57.0 bits (136), Expect = 6e-08
Identities = 73/343 (21%), Positives = 152/343 (44%), Gaps = 42/343 (12%)
Query: 179 EQKKLKLLQKK---QVQIQKEKDQLQGEHSRA---ILARSKLESLCRELQRHNKTLKEEA 232
E+K + LLQ+K Q+Q+Q E + L R I ++ LE+ +EL
Sbjct: 878 EEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELT---------- 927
Query: 233 LQRAREEEEKRKEITS---HFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQY 289
+R EEEE E+ + + + + ++ I+ K+ +E K+K++ ++
Sbjct: 928 -ERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEM 986
Query: 290 ELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVL 349
EE++ K+ K ++ L++A + + + + + L+ A+ + Q L
Sbjct: 987 TALEENISKLTKEKK--------SLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDL 1038
Query: 350 K---EQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWK 406
+ EQE L+A L + E L S E + + + +K+KK E + + +
Sbjct: 1039 EGSLEQEKKLRADLERAKRKLE---GDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQ 1095
Query: 407 ARFENCNKALLDM---IEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEI 463
A+ ++ L I+E R +E E +I L ++++R++L +++ EI
Sbjct: 1096 AKIDDEQVHSLQFQKKIKELQARIEELE---EEIEAEHTLRAKIEKQRSDLARELE--EI 1150
Query: 464 SEKDDQSQHNSDEEPESNVSVDQEIDAEEVNSVQTAVKNLATA 506
SE+ +++ + + E N + E + + +++ ATA
Sbjct: 1151 SERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1193
Score = 37.4 bits (85), Expect = 0.046
Identities = 48/211 (22%), Positives = 88/211 (41%), Gaps = 30/211 (14%)
Query: 128 NKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQ 187
N ++KLE I + + N + ++ N EEK A + +E + EQ L+
Sbjct: 1729 NTKKKLEADIAQCQAEVENSIQESRNA----EEKAKKAITDAAMMAEELKKEQDTSAHLE 1784
Query: 188 KKQVQIQKEKDQLQGEHSRAILAR--------SKLESLCRELQRHNKTLKE---EALQRA 236
+ + +++ LQ A KLE+ REL+ ++ EAL+ A
Sbjct: 1785 RMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGA 1844
Query: 237 REEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHL 296
+ E K KE+T Q+E + K +L +KL++ + Y+ + E
Sbjct: 1845 HKYERKVKEMT---------------YQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEA 1889
Query: 297 DKIFKHRELQQKLVDAKLEQAQEMMKEAEER 327
++ + + + V +LE+A E AE +
Sbjct: 1890 EEQANTQLSRCRRVQHELEEAAERADIAESQ 1920
Score = 36.6 bits (83), Expect = 0.079
Identities = 45/234 (19%), Positives = 108/234 (46%), Gaps = 21/234 (8%)
Query: 134 EKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAEL---LDEHRTEQKKLKLLQKKQ 190
E+++L + L QN + + T ++ + + AE+ + E R ++K K
Sbjct: 1707 EQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDA 1766
Query: 191 VQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHF 250
+ +E + Q + + LE ++LQ ++ AL+ +++ +K
Sbjct: 1767 AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK-------L 1819
Query: 251 QSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKL- 309
++ + +++ +++ + +R + + + K+K + Y+ E+H + I + ++L KL
Sbjct: 1820 ENRVRELENELDVEQKRGAEALKGAHKYERKVKEMT--YQAEEDHKN-ILRLQDLVDKLQ 1876
Query: 310 --VDAKLEQAQEMMKEAEER--HKREKEYLLNQAAEWKLQAKVLKEQETVLQAQ 359
V + QA+E ++A + R ++ L +AAE +A + + Q L+A+
Sbjct: 1877 AKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAE---RADIAESQVNKLRAK 1927
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 73.2 bits (178), Expect = 8e-13
Identities = 94/456 (20%), Positives = 188/456 (41%), Gaps = 62/456 (13%)
Query: 79 KEGSARASEQPENAESPDNEDGDCEETTEEAGREPVASGEPPTVKEPVSNKEQKLEKKIL 138
KE S R E+ E E+ E +E + E VK S KE++ + +
Sbjct: 932 KELSERVEEEEEINSELTARGRKLEDECFELKKE-IDDLETMLVK---SEKEKRTTEHKV 987
Query: 139 KGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKD 198
K L +E L ++++KL + + + + LD+ E++KL L K ++++++ D
Sbjct: 988 KNLTEEVEFLNEDISKLNRAAKVVQ---EAHQQTLDDLHMEEEKLSSLSKANLKLEQQVD 1044
Query: 199 QLQGEHSRAILARSKLESLCRELQRHNKTLKE-----EALQRAREEEEKRKE-------- 245
+L+G + AR E +L+ + K +E E+ QR EE ++KE
Sbjct: 1045 ELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNS 1104
Query: 246 -------ITSHFQSTLTDIQGQIEQQSER--------------NMKLCQENTELAEKLKS 284
+ + Q T+ ++Q QI+ E+ L Q+ +L E+L+
Sbjct: 1105 KVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEE 1164
Query: 285 I----IDQYELREEHLDKIFK-HRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQA 339
+ + Q E+ ++ K K HR++++ + + A ++RH L Q
Sbjct: 1165 VGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSA-----SLKKRHADSLAELEGQV 1219
Query: 340 AEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKK-- 397
+ + L++ ++ LQ ++ R E+ + ++ +++ + + T K+ K
Sbjct: 1220 ENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVT 1279
Query: 398 -LEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGR-LENLCRALQEERNELH 455
L D A K + + + L +EEK E + ++ R N R +++ R +L
Sbjct: 1280 QLANDLAAQKTKLWSESGEFLRRLEEK-------EALINQLSREKSNFTRQIEDLRGQLE 1332
Query: 456 KKIRDAEISEKDDQSQHNSDEEPESNVSVDQEIDAE 491
K+ + Q + +QE+ AE
Sbjct: 1333 KETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAE 1368
Score = 55.8 bits (133), Expect = 1e-07
Identities = 81/398 (20%), Positives = 171/398 (42%), Gaps = 42/398 (10%)
Query: 141 LGKEANLLMQNLNKLQTPEEKFDF-----------LFKKYAELLDEHRTEQKKLKLLQKK 189
+G+E L + +LQ EK +F L ++ +L+ + + EQ+ L ++++
Sbjct: 857 VGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQ 916
Query: 190 QVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRARE---------EE 240
+ K K QL+ + E + EL + L++E + +E +
Sbjct: 917 CEWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKS 976
Query: 241 EKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIF 300
EK K T H LT+ ++E +E KL + + E + +D + EE L +
Sbjct: 977 EKEKRTTEHKVKNLTE---EVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLS 1033
Query: 301 K-HRELQQKL--VDAKLEQAQEMMKEAE-ERHKREKEYLLNQAAEWKLQ------AKVLK 350
K + +L+Q++ ++ LEQ ++ E E HK E LN+ + L+ A+ L+
Sbjct: 1034 KANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELR 1093
Query: 351 EQE---TVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKA 407
++E + + +++ G + Q T+ + K++++ K+E++ A
Sbjct: 1094 KKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQ 1153
Query: 408 RFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKD 467
+ N+ L E + E + + + L R ++E LH + A + ++
Sbjct: 1154 DLADLNERL---EEVGGSSLAQLEITKKQETKFQKLHRDMEEA--TLHFETTSASLKKRH 1208
Query: 468 DQSQHNSDEEPESNVSVDQEIDAEEVNSVQTAVKNLAT 505
S + + E+ V Q+++ ++ + +Q V +L T
Sbjct: 1209 ADSLAELEGQVENLQQVKQKLEKDK-SDLQLEVDDLLT 1245
Score = 47.4 bits (111), Expect = 4e-05
Identities = 54/265 (20%), Positives = 123/265 (46%), Gaps = 24/265 (9%)
Query: 146 NLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQ-KKLKLLQKKQVQIQKEKDQLQGEH 204
+LL L L++ +E+ + + L +E E +++ L + + +K +L+ +
Sbjct: 1691 SLLQSELEDLRSLQEQTE----RGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADV 1746
Query: 205 SRAILARSKLESLCRELQRHNKTLKEEALQRAR--EEEEKRKEITSHFQ-------STLT 255
+R + + E + +E Q + K+ A++ A EE +K+++ +H + T+T
Sbjct: 1747 ARM---QKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTIT 1803
Query: 256 DIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLE 315
D+Q ++ + + M L ++ +KL+S + EL E +I + E Q+ +LE
Sbjct: 1804 DLQKRLAEAEQ--MALMGSRKQI-QKLESRVR--ELEGELEGEIRRSAEAQRGA--RRLE 1856
Query: 316 QAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLT 375
+ + + E K+ + Q + +L+ + K+Q V + Q Y ++++ Q L
Sbjct: 1857 RCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELN 1916
Query: 376 KSNEVFATFKQEMDKTTKKMKKLEK 400
+ E + +++K K ++ K
Sbjct: 1917 EVKERAEVAESQVNKLKIKAREFGK 1941
Score = 39.7 bits (91), Expect = 0.009
Identities = 68/360 (18%), Positives = 149/360 (41%), Gaps = 56/360 (15%)
Query: 165 LFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRH 224
L+ + E L ++ + L +++ ++ + L+G+ + ++S L ++ QR
Sbjct: 1292 LWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRD 1351
Query: 225 NKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQS--------ERNMKLCQENT 276
L RE+ E+ +E+ + TL+ + ++ Q +R L
Sbjct: 1352 CDLL--------REQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKK 1403
Query: 277 ELAEKLKSIIDQYELREEHLDKIFKHR-ELQQKLVD------------AKLEQAQEMMKE 323
ELA +L+ + + + + R +LQ +L D A+L+Q Q +
Sbjct: 1404 ELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGK 1463
Query: 324 --AEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEF---QSTLTKSN 378
A+ + K E+ L A++ ++QA L +L +EE Q TL + N
Sbjct: 1464 ALADWKQKHEESQALLDASQKEVQA---------LSTELLKLKNTYEESIVGQETLRREN 1514
Query: 379 EVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYE-CFVMKI 437
+ ++E+ T ++++ K+ E K + + E + +E E
Sbjct: 1515 K---NLQEEISNLTNQVREGTKNL----TEMEKVKKLIEEEKTEVQVTLEETEGALERNE 1567
Query: 438 GRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEPESNVSVDQEIDAEEVNSVQ 497
++ + L E + EL +K +SEKD++ ++ ++ + S+ +D+E + ++
Sbjct: 1568 SKILHFQLELLEAKAELERK-----LSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIE 1622
Score = 39.7 bits (91), Expect = 0.009
Identities = 84/451 (18%), Positives = 173/451 (38%), Gaps = 63/451 (13%)
Query: 152 LNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLK-LLQKKQVQIQKEKDQLQGEHSRAILA 210
+N+L + F + L++ Q L LQK Q ++Q + E
Sbjct: 1310 INQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAEL 1369
Query: 211 RSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMK 270
L + E+ + + +QR + E+ +KE+ Q + + +
Sbjct: 1370 HRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERA 1429
Query: 271 LCQENTELAEKLKSI---------IDQYELREEHLDKIFKHR-ELQQKLVDAKLEQAQEM 320
Q EL + L + +DQ +L+ +K + E Q L+DA ++ Q +
Sbjct: 1430 RHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQAL 1489
Query: 321 MKE-------------AEERHKREKEYLLNQAA--------------EWKLQAKVLKEQE 353
E +E +RE + L + + E + K+++E++
Sbjct: 1490 STELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEK 1549
Query: 354 TVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMD-KTTKKMKKLE----KDTATWKAR 408
T +Q L G E +S + K E++ K ++K +++E K T +
Sbjct: 1550 TEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSL 1609
Query: 409 FENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQE---ERNELHKKIRDAEISE 465
+ + IE L+ K E +L R + E +L +I+D ++ +
Sbjct: 1610 QSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQM-Q 1668
Query: 466 KDDQSQHNSDEEPESNVSVDQ----EIDAEEVNSVQTAVKN----------LATAFMIIH 511
DD +Q NSD + + V+ + + + E++ S+Q + AT + +
Sbjct: 1669 LDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLF 1728
Query: 512 HPESTP--HQSKETQPEIGSSQESADAALKE 540
+ ++T Q K+ + ++ Q+ A+ ++E
Sbjct: 1729 YTQNTSLLSQKKKLEADVARMQKEAEEVVQE 1759
Score = 30.4 bits (67), Expect = 5.7
Identities = 22/97 (22%), Positives = 46/97 (47%), Gaps = 6/97 (6%)
Query: 135 KKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQ 194
++ +K L +A +NL+++QT +K + Y + ++ T+ + KKQ
Sbjct: 1856 ERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQ---- 1911
Query: 195 KEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEE 231
+ +L RA +A S++ L + + K ++EE
Sbjct: 1912 --QHELNEVKERAEVAESQVNKLKIKAREFGKKVQEE 1946
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 72.8 bits (177), Expect = 1e-12
Identities = 89/400 (22%), Positives = 176/400 (44%), Gaps = 51/400 (12%)
Query: 83 ARASEQPENAESPDNEDGDCEETTEEAGREPVASGEPPTVKE------PVSNKEQKLEKK 136
A+ E E E D E+ + E T ++ E S + + V ++ E K
Sbjct: 919 AKVKEMNERLE--DEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 976
Query: 137 ILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKE 196
+ K L +E L + + KL T E+K L + + + LD+ + E+ K+ L K +V+++++
Sbjct: 977 V-KNLTEEMAGLDEIIAKL-TKEKKA--LQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQ 1032
Query: 197 KDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAR-----EEEEKRKEITSHFQ 251
D L+G + R LE R+L+ K +E + EE+ K+KE + Q
Sbjct: 1033 VDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQ 1092
Query: 252 STLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVD 311
++ + + + Q ++ +K EN E+L+ ++ ++K+ + +
Sbjct: 1093 NSKIEDEQVLALQLQKKLK---ENQARIEELEEELEAERTARAKVEKL-------RSDLS 1142
Query: 312 AKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQ 371
+LE+ E ++EA + E + AE++ + L +E LQ + T + R
Sbjct: 1143 RELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDL--EEATLQHEATAAALR----- 1195
Query: 372 STLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYE 431
K + A +++D + +KLEK+ + +K ++ + +I+ KA
Sbjct: 1196 ---KKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKA------- 1245
Query: 432 CFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQ 471
LE + R L+++ NE K+ +A+ S D +Q
Sbjct: 1246 -------NLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQ 1278
Score = 67.4 bits (163), Expect = 4e-11
Identities = 96/440 (21%), Positives = 188/440 (42%), Gaps = 40/440 (9%)
Query: 55 ISEELNRQLEDI---INTYGSAASTAGKEGSARASEQPENAESPDNEDGDCEETTEEAGR 111
+ +L+R+LE+I + G A S + R +E + D E+ + A
Sbjct: 1137 LRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRR--DLEEATLQHEATAAAL 1194
Query: 112 EPVASGEPPTVKEPVSNKE---QKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKK 168
+ + E + N + QKLEK+ + E + + N+ ++ + + + +
Sbjct: 1195 RKKHADSVAELGEQIDNLQRVKQKLEKEKSE-FKLELDDVTSNMEQIIKAKANLEKVSRT 1253
Query: 169 YAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRH--NK 226
+ +E+R KL+ Q+ ++ +LQ E+ + E+L +L R +
Sbjct: 1254 LEDQANEYRV---KLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSY 1310
Query: 227 TLKEEALQRAREEEEKRKEITSH-FQSTLTD---IQGQIEQQSERNMKL----CQENTEL 278
T + E L+R EEE K K +H QS D ++ Q E+++E +L + N+E+
Sbjct: 1311 TQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEV 1370
Query: 279 AEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQAQEM-------MKEAEERHKRE 331
A+ R E L++ K +L Q+L DA E+A E +++ + R + E
Sbjct: 1371 AQWRTKYETDAIQRTEELEEAKK--KLAQRLQDA--EEAVEAVNAKCSSLEKTKHRLQNE 1426
Query: 332 KEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKT 391
E L+ A L +++ L + ++EE QS L S + + E+ K
Sbjct: 1427 IEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKL 1486
Query: 392 TKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEER 451
++ + T+K +N + + D+ E+ K + LE + + L+ E+
Sbjct: 1487 KNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGK-------NVHELEKVRKQLEVEK 1539
Query: 452 NELHKKIRDAEISEKDDQSQ 471
EL + +AE S + ++ +
Sbjct: 1540 LELQSALEEAEASLEHEEGK 1559
Score = 61.2 bits (147), Expect = 3e-09
Identities = 72/399 (18%), Positives = 173/399 (43%), Gaps = 48/399 (12%)
Query: 131 QKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQ 190
QK + + L K N ++L L+T + + L ++ ++L ++ K + L+K +
Sbjct: 1473 QKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVR 1532
Query: 191 VQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHF 250
Q++ EK +LQ A + E Q +K E ++ E++E+ ++ +
Sbjct: 1533 KQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNH 1592
Query: 251 QSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLV 310
Q + +Q ++ ++ E + +K++ +++ E++ H +++ + Q K +
Sbjct: 1593 QRVVDSLQTSLDAETRSR----NEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSL 1648
Query: 311 DAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEF 370
+ L+ Q + +A + KE + +++ + +LQA+L EE
Sbjct: 1649 QSLLKDTQIQLDDAVRANDDLKENI-----------AIVERRNNLLQAEL-------EEL 1690
Query: 371 QSTLTKSNEVFATFKQEMDKTTKKM--------------KKLEKDTATWKARFE------ 410
++ + ++ +QE+ +T++++ KK+E D ++ E
Sbjct: 1691 RAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQEC 1750
Query: 411 -NCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAE-ISEKDD 468
N + I + A+ A+E + LE + + +++ +L ++ +AE I+ K
Sbjct: 1751 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGG 1810
Query: 469 QSQHNSDE----EPESNVSVDQEIDAEEVNSVQTAVKNL 503
+ Q E E E + +Q+ +AE V ++ + + +
Sbjct: 1811 KKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRI 1849
Score = 50.8 bits (120), Expect = 4e-06
Identities = 85/374 (22%), Positives = 155/374 (41%), Gaps = 65/374 (17%)
Query: 179 EQKKLKLLQKK---QVQIQKEKDQLQGEHSRA---ILARSKLESLCRELQRHNKTLKEEA 232
E+K + LLQ+K Q+Q+Q E+D L R I + +LE+ +E+ N+ L++E
Sbjct: 876 EEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEM---NERLEDEE 932
Query: 233 LQRAREEEEKRK--EITSHFQSTLTDIQ---GQIEQQSE------RNM------------ 269
A +KRK + S + + D++ ++E++ +N+
Sbjct: 933 EMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIA 992
Query: 270 KLCQENTELAEKLKSIIDQYELREEHLDKIFKHR-ELQQKL--VDAKLEQAQEMMKEAEE 326
KL +E L E + +D ++ E+ ++ + K + +L+Q++ ++ LEQ +++ + E
Sbjct: 993 KLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLER 1052
Query: 327 -RHKREKEYLLNQAA-------EWKLQAKVLK------------EQETVLQAQLTLYSGR 366
+ K E + L Q + + +L+ K+ K E E VL QL +
Sbjct: 1053 AKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQL---QKK 1109
Query: 367 FEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALR 426
+E Q+ + + E + K K L ++ R E A IE R
Sbjct: 1110 LKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKR 1169
Query: 427 AKEYECFVMKIGR-LENLCRALQEERNELHKKIRD--AEISEKDDQSQHNSDEEPESNVS 483
E++ K+ R LE + L KK D AE+ E+ D Q + +
Sbjct: 1170 EAEFQ----KMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1225
Query: 484 VDQEIDAEEVNSVQ 497
E+D N Q
Sbjct: 1226 FKLELDDVTSNMEQ 1239
Score = 39.3 bits (90), Expect = 0.012
Identities = 43/226 (19%), Positives = 96/226 (42%), Gaps = 27/226 (11%)
Query: 122 VKEPVSNKEQKLEKKILKGLGKEANLLMQN---LNKLQTPEEKFDFLFKKYAELLDEHRT 178
V E + E+++++ + L QN +N+ + E L + E + E R
Sbjct: 1693 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRN 1752
Query: 179 EQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRARE 238
++K K + +E + Q + + +E ++LQ ++ AL+ ++
Sbjct: 1753 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK 1812
Query: 239 EEEKRKEITSHFQSTLTDIQGQIE-------------QQSERNMKLCQENTELAEK---- 281
+ +K ++ + +++G++E ++SER +K TE +K
Sbjct: 1813 QLQK-------LEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLR 1865
Query: 282 LKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEER 327
L+ ++D+ +L+ + + + E Q +K + Q + EAEER
Sbjct: 1866 LQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEER 1911
Score = 33.5 bits (75), Expect = 0.67
Identities = 43/205 (20%), Positives = 88/205 (42%), Gaps = 43/205 (20%)
Query: 128 NKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDE--HRTEQKKLKL 185
N E+K +K I +A ++ + L K Q + + K + + + HR ++ +
Sbjct: 1752 NAEEKAKKAIT-----DAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAE--- 1803
Query: 186 LQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKE---EALQRAREEEEK 242
Q+ ++ K QLQ KLE+ REL+ + ++ E+++ R+ E +
Sbjct: 1804 ----QIALKGGKKQLQ-----------KLEARVRELEGELEAEQKRNAESVKGMRKSERR 1848
Query: 243 RKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKH 302
KE+T Q+E + K +L +KL+ + Y+ + E ++
Sbjct: 1849 IKELT---------------YQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANT 1893
Query: 303 RELQQKLVDAKLEQAQEMMKEAEER 327
+ + V +L++A+E AE +
Sbjct: 1894 NLSKFRKVQHELDEAEERADIAESQ 1918
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 72.8 bits (177), Expect = 1e-12
Identities = 86/424 (20%), Positives = 188/424 (44%), Gaps = 29/424 (6%)
Query: 83 ARASEQPENAESPDNEDGDCEETTEEAGREPVASGEPPTVKE------PVSNKEQKLEKK 136
A+ E E AE D E+ + E T ++ E S + + V ++ E K
Sbjct: 921 AKIKEVTERAE--DEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 978
Query: 137 ILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKE 196
+ K L +E L + + KL T E+K L + + + LD+ + E+ K+ L K + +++++
Sbjct: 979 V-KNLTEEMAGLDETIAKL-TKEKKA--LQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQ 1034
Query: 197 KDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTD 256
D L+G + LE R+L+ K +E + ++++ +++ + +++
Sbjct: 1035 VDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKK-EFEMSN 1093
Query: 257 IQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQ 316
+QG+IE + ++L ++ EL +++ + ++ E K E Q+ + +LE+
Sbjct: 1094 LQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAK----AEKQRSDLSRELEE 1149
Query: 317 AQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTK 376
E ++EA + E + AE++ + L+E +A + + + L +
Sbjct: 1150 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGE 1209
Query: 377 SNEVFATFKQEMDKTTKKMKKLEKDTAT-------WKARFENCNKALLDMIEEKALRAKE 429
+ KQ+++K ++K D A+ KA FE + L D + E + +E
Sbjct: 1210 QIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEE 1269
Query: 430 YECFVMKIGRLENLCRALQEERNELHKKI--RDAEISEKDDQSQHNSDEEPESNVSVDQE 487
+ + ++ + L E E +++ +DA +S+ Q + + E +++E
Sbjct: 1270 QQRLINELSAQK---ARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEE 1326
Query: 488 IDAE 491
A+
Sbjct: 1327 TKAK 1330
Score = 63.2 bits (152), Expect = 8e-10
Identities = 87/457 (19%), Positives = 186/457 (40%), Gaps = 64/457 (14%)
Query: 131 QKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQ 190
QK + + L K N ++L+ L+T + + L ++ ++L ++ K + L+K +
Sbjct: 1475 QKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVK 1534
Query: 191 VQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHF 250
Q+ EK +LQ A + E +Q +K E ++ E++E+ ++ +
Sbjct: 1535 KQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNH 1594
Query: 251 QSTLTDIQGQIEQQ------------------SERNMKLCQENTELAEKLKSIIDQYELR 292
+ +Q ++ + +E ++L N + AE L+++ + +
Sbjct: 1595 LRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGIL 1654
Query: 293 EE---HLDKIFKHR----------ELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQA 339
++ HLD + + E + L+ A++E+ + ++ E K ++ LL+ +
Sbjct: 1655 KDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDAS 1714
Query: 340 AEWKL---QAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMK 396
+L Q L + L+ ++ G E+ + E + +++K
Sbjct: 1715 ERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELK 1774
Query: 397 KLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHK 456
K E+DT+ A E K + +++ LR E E +K G+ ++ +L
Sbjct: 1775 K-EQDTS---AHLERMKKNMEQTVKDLQLRLDEAEQLALKGGK---------KQIQKLEA 1821
Query: 457 KIRDAEISEKDDQSQHNSD--------EEPESNVSVDQEIDAEEVNSVQTAVKNLATAFM 508
++R+ E SE + + +HN + E ++ E D + + +Q V L T
Sbjct: 1822 RVRELE-SEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVK 1880
Query: 509 II-HHPESTPHQS-------KETQPEIGSSQESADAA 537
E QS ++ Q E+ ++E AD A
Sbjct: 1881 AYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIA 1917
Score = 44.3 bits (103), Expect = 4e-04
Identities = 51/216 (23%), Positives = 95/216 (43%), Gaps = 43/216 (19%)
Query: 117 GEPPTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEH 176
GE + + N E+K +K I +A ++ + L K Q + + K E
Sbjct: 1743 GEMEDIVQEARNAEEKAKKAIT-----DAAMMAEELKKEQDTSAHLERMKKNM-----EQ 1792
Query: 177 RTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRA 236
+ +L+L + +Q+ ++ K Q+Q +R +LES Q+HN EA++
Sbjct: 1793 TVKDLQLRLDEAEQLALKGGKKQIQKLEARV----RELESEVESEQKHNV----EAVKGL 1844
Query: 237 REEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHL 296
R+ E + KE+T Q+E + K +L +KL++ + Y+ + E
Sbjct: 1845 RKHERRVKELT---------------YQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEA 1889
Query: 297 DK-----IFKHRELQQKLVDAKLEQAQEMMKEAEER 327
++ + K R+LQ +L E+A+E AE +
Sbjct: 1890 EEQSNVNLAKFRKLQHEL-----EEAKERADIAESQ 1920
Score = 43.5 bits (101), Expect = 6e-04
Identities = 76/384 (19%), Positives = 167/384 (43%), Gaps = 61/384 (15%)
Query: 47 KEASVHPDISEELNRQLEDIINTYGSAASTAGKEGSARASEQPENAESPDNEDGDCEETT 106
++A +H + S E +RQL++ A + G ++Q E + E+ + T
Sbjct: 1280 QKARLHTE-SGEFSRQLDE-----KDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTL 1333
Query: 107 EEAGREPVASGEPPTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPE----EKF 162
A + A + ++E +EQ+ + ++ +G+ K + + Q K +T E+
Sbjct: 1334 AHALQS--ARHDCDLLREQYE-EEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEEL 1390
Query: 163 DFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQ 222
+ KK A+ L + ++ ++ + K ++K K +LQ E +E L +++
Sbjct: 1391 EEAKKKLAQRLQD---AEEHVEAVNSKCASLEKTKQRLQNE----------VEDLMIDVE 1437
Query: 223 RHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKL 282
R N AL + + +K + + ++ + Q ++E + E+ L+ +L
Sbjct: 1438 RSNAACI--ALDKKQRNFDK---VLAEWKQKYEETQAELEASQK-------ESRSLSTEL 1485
Query: 283 KSIIDQYELREEHLDKIFK-HRELQQKLVDAKLEQAQ--------EMMKEAEERHKREKE 333
+ + YE +HL+ + + ++ LQQ++ D + A+ E +K+ + K E +
Sbjct: 1486 FKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQ 1545
Query: 334 YLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTK 393
L +A +A + E+ +L+ QL E ++ + A +E+D+ +
Sbjct: 1546 TSLEEA-----EASLEHEEGKILRIQL--------ELNQVKSEIDRKIAEKDEELDQLKR 1592
Query: 394 K-MKKLEKDTATWKARFENCNKAL 416
++ +E +T A + N AL
Sbjct: 1593 NHLRVVESMQSTLDAEIRSRNDAL 1616
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 72.4 bits (176), Expect = 1e-12
Identities = 108/523 (20%), Positives = 215/523 (41%), Gaps = 68/523 (13%)
Query: 79 KEGSARASEQPENAESPDNEDGDCEETT----------EEAGREPVASGEPPTVKEPVSN 128
K+ ++ + +PE + D E D EET E RE + P+ +
Sbjct: 175 KKKASNGNARPETVTNDDEEALD-EETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHP 233
Query: 129 KEQKLEKKI-------LKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQK 181
+++K EKK + L + +++N ++ E+K D + ++ ++ D H+ ++
Sbjct: 234 RKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEE 293
Query: 182 KLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEE 241
+ +K++ +I+KE+ + + E R R + E RE +R + +E+ +R RE E
Sbjct: 294 EKGKKEKERQEIEKERRERERERER---ERERRE---REREREREREREKEKERERERER 347
Query: 242 KRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFK 301
R + + D + ++ ER+ ++ + EK + + E E + +
Sbjct: 348 DRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERER 407
Query: 302 HRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLT 361
RE ++ + E+ +E +E E+ KR++E A E + + L+E+E Q +L
Sbjct: 408 ERERER-----EREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLK 462
Query: 362 LYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIE 421
+ R + K E ++EM K K++K+ +D + + + L
Sbjct: 463 NWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSAL---- 518
Query: 422 EKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEPESN 481
+K LR +E E E +E +K E+ E + +P++
Sbjct: 519 QKRLRDREKEM-----------------EADERDRKREKEELEEIRQRLLAEGHPDPDAE 561
Query: 482 VSVDQEIDAEEVNSVQTAVKNLATAFMIIHHPESTPHQSKETQPEIGSSQESADAALKEP 541
+ Q ++ E Q +K PES + +E + E +E +EP
Sbjct: 562 L---QRMEQEAERRRQPQIK---------QEPES--EEEEEEKQEKEEKREEPMEEEEEP 607
Query: 542 EQPPLIPSRDSESPLPPLTPQAEAEGGSDAEPPSKASNSPAGL 584
EQ P + + + P+ + A G +A P + SP G+
Sbjct: 608 EQKPCL--KPTLRPISSAPSVSSASG--NATPNTPGDESPCGI 646
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 72.4 bits (176), Expect = 1e-12
Identities = 109/531 (20%), Positives = 215/531 (40%), Gaps = 89/531 (16%)
Query: 32 KEDGQDSPTPVQPPEKEASVHPDISEELNRQLEDIINTYGSAA-------STAGKEGSAR 84
++ QDSPT ++ E E + EELNR+LE++ TYG+ A K+
Sbjct: 147 EQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGI 206
Query: 85 ASEQPENAESPDNEDGDCE----ETTEEAGREPVA------------SGEPPTVKEPVSN 128
++ N + E + E TE++ + + S T + +
Sbjct: 207 ITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQA 266
Query: 129 KEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYA--ELLDEHRTEQKKLKLL 186
K+Q L + + L ++ +LL K + + FL +K E+ + + E + +
Sbjct: 267 KQQILTHQ--QQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEI 324
Query: 187 QKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEI 246
Q+K+ I++ ++ E + + + KL + + L L+E+ +Q+ +E + + E+
Sbjct: 325 QEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGE----LQEQIVQKNQEIKNMKLEL 380
Query: 247 TSHFQ------STLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQ--YELREEHLDK 298
T+ Q + + G +E+ +RN K Q T++ ++++ + +LR E LD+
Sbjct: 381 TNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAE-LDE 439
Query: 299 IFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQA 358
++ + +Q K + Q M+E + RHK E E L + TV +
Sbjct: 440 MYGQQIVQMK--QELIRQHMAQMEEMKTRHKGEMENALRSYS-----------NITVNED 486
Query: 359 QLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLD 418
Q+ L + E L +N K+E+ ++ L++ L D
Sbjct: 487 QIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQ--------------LED 532
Query: 419 MIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEP 478
++EE + ++ I R + + NE HK + E + + S S +E
Sbjct: 533 LVEELSFSREQ-------IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKEL 585
Query: 479 E-------SNVSVDQEIDAEEVNSV--------QTAVKNLATAFMIIHHPE 514
E +N + E+ +E N+V + ++ L T + H E
Sbjct: 586 ELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEE 636
Score = 57.8 bits (138), Expect = 3e-08
Identities = 109/503 (21%), Positives = 201/503 (39%), Gaps = 81/503 (16%)
Query: 36 QDSPTPVQPPEKEASVHPDISEELNRQLEDIINTYGSAASTAGKEGSARASEQPENAESP 95
QD+ + + ++E + + L RQLED++ + +E RA + ES
Sbjct: 503 QDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS-----REQIQRARQTIAEQESK 557
Query: 96 DNEDGDCEETTEEAGREPVASGEPPTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKL 155
NE T E+ E V++ E E E K L+ L KE N ++ + +
Sbjct: 558 LNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAES 617
Query: 156 QTPEE---KFDFLFKKYAELLD-------EHRTEQKKLK----LLQKKQVQ--------- 192
Q E + LF EL EHR +KLK + K+Q+
Sbjct: 618 QEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQK 677
Query: 193 ---IQKEKDQLQGEHSRAILARSKLESL---------------CRELQRHNKTLKEEALQ 234
+Q EKD L + ++ IL SKL+ L ELQ+ + L++E +
Sbjct: 678 IETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKE 737
Query: 235 RAREEEE------KRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLK--SII 286
+ E+E K + + + D+Q + Q N L E L + LK + +
Sbjct: 738 KGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPV 797
Query: 287 DQYELREEHLDKIFKHRE--LQQKLVDAKLEQAQEMMKEA----EERHKR-------EKE 333
Q E R LD I + + +K ++ +E+ +++ ++ EE K+ EK
Sbjct: 798 SQEE-RLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKN 856
Query: 334 YLLNQAA---EWKLQAKVLKEQETVLQAQLTLYSGRFEEFQ----------STLTKSNEV 380
+ +N E+ KV + E Q Y + + +T+ + V
Sbjct: 857 FEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSV 916
Query: 381 FATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRL 440
F K + +T + + +EKDT + E + L++ + + +++ + +I L
Sbjct: 917 FDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFL 976
Query: 441 ENLCRALQEERNELHKKIRDAEI 463
++L++E+ ++ + R+ EI
Sbjct: 977 NEEVKSLKQEKEQVSLRCRELEI 999
Score = 46.2 bits (108), Expect = 1e-04
Identities = 109/598 (18%), Positives = 234/598 (39%), Gaps = 93/598 (15%)
Query: 158 PEEKFDFLFKKYAELLDEHRTEQKKLK-LLQKKQVQIQKEKDQLQGEHSRAILARSKLES 216
PE + + + +D E L+ L++ + +++ + +++Q H + + + + +
Sbjct: 2183 PELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT 2242
Query: 217 LCRELQRHNKTLKE--EALQRAREEEEKRKEITSH-----FQSTLTDIQGQIEQQSERNM 269
+EL++ NK K+ E L A +E + H F + + + +I+Q +E+
Sbjct: 2243 RLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVT 2302
Query: 270 KLCQE------NTELAEK---LKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQAQEM 320
KL Q+ N + EK ++ + Q E + + ++RE + + ++ +E+ Q+
Sbjct: 2303 KLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQE 2362
Query: 321 MKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEV 380
+ ++ L +A K Q V+ ++ L+ Q+ + ++ L ++N
Sbjct: 2363 LANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFK 2422
Query: 381 FATFKQEMDKTTKKMKKLEKDTA----TWKARFENCNK---ALLDMIEEKALRAKEYECF 433
QE+ ++ + +EK + + ++ +K L ++ E AL++ E + +
Sbjct: 2423 MNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTY 2482
Query: 434 V---------------MKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEP 478
++ +LE+ A E + +K+I+D + +Q Q ++
Sbjct: 2483 FKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQ-----EQGQFETEMLQ 2537
Query: 479 ESNVSVDQEIDAE---------EVNSVQTAVKNLATAFMIIHHPESTPHQ--SKETQPEI 527
+ V++ + ++ + ++ +VQ K I PE T Q ++ + E+
Sbjct: 2538 KKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDEL 2597
Query: 528 GSS---------------QESADAALKEPEQPPLIPSRDSESPLPPLTPQAEAEGGSDAE 572
GS E + + E EQ + E L Q EG +
Sbjct: 2598 GSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQ 2657
Query: 573 PPSKASNSPAGL----------------GAETQCEGL---PVGAQADQASWKPEAEASGQ 613
+ SP + G + E L V +A+ AS+K +AE +
Sbjct: 2658 REKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQE 2717
Query: 614 --APQAPTEASLQKMEADVPAPACAAEEHVAAMVPACEPSRQPPRAAA--EELPVGAS 667
+ SLQK + V A+E ++ + E Q + A E LP+ S
Sbjct: 2718 ELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLS 2775
Score = 45.8 bits (107), Expect = 1e-04
Identities = 69/313 (22%), Positives = 125/313 (39%), Gaps = 34/313 (10%)
Query: 189 KQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITS 248
+++ +++E++ + + +S E+Q ++K+ A + +E+ K + +
Sbjct: 3104 RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATE-LQEQLSSEKMVVA 3162
Query: 249 HFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHL-DKIFKHRELQQ 307
+S L + ++E + K +E ++K D+ L + L + K RELQ
Sbjct: 3163 ELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQW 3222
Query: 308 KLVDAKLEQAQEMMKEAEERHKREKEYL---LNQAAEWKLQAKVLKEQETVL-------- 356
L E+ + + +EER K E E L L + LQ +L EQ+ L
Sbjct: 3223 AL-----EKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKI 3277
Query: 357 -------QAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKAR- 408
AQL+ GR E Q L +D+ + +L+ T ++R
Sbjct: 3278 ESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRP 3337
Query: 409 ---FENCNKALLDMIEEKALRAKEY--ECFVMKIGRLENLCRALQEERNELHKKIRDAEI 463
E+ K L +EEK R E E K+ L+ R E+ ++H+K E
Sbjct: 3338 PLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT--RQQMEKDRQVHRKTLQTE- 3394
Query: 464 SEKDDQSQHNSDE 476
E + + Q E
Sbjct: 3395 QEANTEGQKKMHE 3407
Score = 45.1 bits (105), Expect = 2e-04
Identities = 60/282 (21%), Positives = 130/282 (46%), Gaps = 32/282 (11%)
Query: 140 GLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQ 199
G G NL + L T K L + Y ++ D Q + ++LQKK V +QK ++
Sbjct: 2490 GKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEE 2549
Query: 200 LQGEHSRAILARSKLESL------CRELQRHNKTLKEEALQRARE--EEEKRKEITSHFQ 251
+ + A++++ +LE++ C++ Q + + +Q + E+E +I S
Sbjct: 2550 ---KVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDI-SALT 2605
Query: 252 STLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVD 311
+++++ Q+ + ++ L +E E+AE K+++++ E + L K+ + E +Q+ +
Sbjct: 2606 LRISELESQVVEM-HTSLILEKEQVEIAE--KNVLEK-EKKLLELQKLLEGNEKKQREKE 2661
Query: 312 AKLE-QAQEMMKEAEER-HKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEE 369
K Q E++K E H E+ N + + L+ + +A+L Y + E+
Sbjct: 2662 KKRSPQDVEVLKTTTELFHSNEESGFFN-------ELEALRAESVATKAELASYKEKAEK 2714
Query: 370 FQ-------STLTKSNEVFATFKQEMDKTTKKMKKLEKDTAT 404
Q + +T + + + + + +K+ LEK+ T
Sbjct: 2715 LQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDET 2756
Score = 43.5 bits (101), Expect = 6e-04
Identities = 74/372 (19%), Positives = 151/372 (40%), Gaps = 43/372 (11%)
Query: 150 QNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAIL 209
QN N+ Q E+ F K+ + + E ++L ++ +QK ++L +
Sbjct: 1686 QNGNENQGEVEEQTFKEKEL-----DRKPEDVPPEILSNERYALQKANNRLLKILLEVVK 1740
Query: 210 ARSKLESLCRE-----LQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTD-----IQG 259
+ +E L R +K+ +L E E K + +TD G
Sbjct: 1741 TTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSG 1800
Query: 260 QIEQQSERNM--KLCQENTELAEKL-KSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQ 316
+++ NM K+ +E TEL+++L +S E+ E+ + + Q V+ LE
Sbjct: 1801 SDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA 1860
Query: 317 AQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTK 376
E + E + E + + + + LK QE L+ +L S E+ L+K
Sbjct: 1861 ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEE-LRERLHEESRAREQLAVELSK 1919
Query: 377 SNEVF-------ATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKE 429
+ V F++++ + T + +LE++ R + + EE+ L +++
Sbjct: 1920 AEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQ 1979
Query: 430 YECFVMKIG----------------RLENLCRALQEERNELHKKIRDAEISEKDDQSQHN 473
E + G +LE C+A ++ R++L K+++ EI ++ S+
Sbjct: 1980 KEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQA-EKVRDDLQKQVKALEIDVEEQVSRFI 2038
Query: 474 SDEEPESNVSVD 485
E+ ++ +D
Sbjct: 2039 ELEQEKNTELMD 2050
Score = 40.8 bits (94), Expect = 0.004
Identities = 52/210 (24%), Positives = 101/210 (48%), Gaps = 35/210 (16%)
Query: 123 KEPVSNKEQKLEKKIL---------KGLGKEANLLMQNLN-KLQTPEEKFDFLFKKYAEL 172
K+ ++ +QK+E + + +G E +L+++ +++ D + +A+L
Sbjct: 3267 KQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQL 3326
Query: 173 LDEHRTEQKKLKLLQKKQV-QIQKEKDQLQGEHSRAI-----LARSKLESLC------RE 220
T Q + L + + ++QK QL+ +HSR + + KL+SL ++
Sbjct: 3327 QSSDGTGQSRPPLPSEDLLKELQK---QLEEKHSRIVELLNETEKYKLDSLQTRQQMEKD 3383
Query: 221 LQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAE 280
Q H KTL+ E Q A E +K+ QS + D+Q Q+E++ ++ KL E +
Sbjct: 3384 RQVHRKTLQTE--QEANTEGQKKMH---ELQSKVEDLQRQLEEKRQQVYKLDLE----GQ 3434
Query: 281 KLKSIIDQYELRE-EHLDKIFKHRELQQKL 309
+L+ I+ +++ +E E +K R L Q L
Sbjct: 3435 RLQGIMQEFQKQELEREEKRESRRILYQNL 3464
Score = 39.3 bits (90), Expect = 0.012
Identities = 91/444 (20%), Positives = 176/444 (39%), Gaps = 61/444 (13%)
Query: 57 EELNRQLEDIINTYGSAASTAGKEGSARASEQPENAESPDNEDGDCEETTEEAGREPVAS 116
EE QL ++I + G++ S A E A+S ++ V
Sbjct: 2346 EEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQ-------------LDVVI 2392
Query: 117 GEPPTVKEPV--SNKEQKLEKKILKGLGKEANLLMQNLNKLQTPE---EKFDFLFKKYAE 171
E +++ V +N+E K +LK + N L Q L L+ EK + +
Sbjct: 2393 AEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVN 2452
Query: 172 LLDEHRTEQK----------KLKLLQKKQVQIQKE---KDQLQGEHSRAILARSKLESLC 218
+ +H ++ K LK L+ + E K + +R + S + +
Sbjct: 2453 VAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKD 2512
Query: 219 RELQRHNKTLKEEALQRAREEEEKRKEITS----HFQSTLTDIQGQIEQQS-ERNMKLCQ 273
EL + K +K+ Q E E +K+I + + + QI+ ++ + K CQ
Sbjct: 2513 LELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQ 2572
Query: 274 ENTELAEKLK--SIIDQYELREEHLDKIFKHRELQ-QKLVDAKLEQAQEMMKEAEERHKR 330
+N ++ + + +I + +LRE+ L L+ +L +E ++ E E+
Sbjct: 2573 DNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIA 2632
Query: 331 EKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTK---SNEVFATFKQE 387
EK L + +LQ K+L+ E + + S + E T T+ SNE + F E
Sbjct: 2633 EKNVLEKEKKLLELQ-KLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEE-SGFFNE 2690
Query: 388 MDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRAL 447
++ + + + A++K + E + LL +K + +L + L
Sbjct: 2691 LEALRAESVATKAELASYKEKAEKLQEELL-----------------VKETNMTSLQKDL 2733
Query: 448 QEERNELHKKIRDAEISEKDDQSQ 471
+ R+ L + I EK+D+++
Sbjct: 2734 SQVRDHLAEAKEKLSILEKEDETE 2757
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 72.4 bits (176), Expect = 1e-12
Identities = 109/531 (20%), Positives = 215/531 (40%), Gaps = 89/531 (16%)
Query: 32 KEDGQDSPTPVQPPEKEASVHPDISEELNRQLEDIINTYGSAA-------STAGKEGSAR 84
++ QDSPT ++ E E + EELNR+LE++ TYG+ A K+
Sbjct: 147 EQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGI 206
Query: 85 ASEQPENAESPDNEDGDCE----ETTEEAGREPVA------------SGEPPTVKEPVSN 128
++ N + E + E TE++ + + S T + +
Sbjct: 207 ITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQA 266
Query: 129 KEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYA--ELLDEHRTEQKKLKLL 186
K+Q L + + L ++ +LL K + + FL +K E+ + + E + +
Sbjct: 267 KQQILTHQ--QQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEI 324
Query: 187 QKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEI 246
Q+K+ I++ ++ E + + + KL + + L L+E+ +Q+ +E + + E+
Sbjct: 325 QEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGE----LQEQIVQKNQEIKNMKLEL 380
Query: 247 TSHFQ------STLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQ--YELREEHLDK 298
T+ Q + + G +E+ +RN K Q T++ ++++ + +LR E LD+
Sbjct: 381 TNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAE-LDE 439
Query: 299 IFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQA 358
++ + +Q K + Q M+E + RHK E E L + TV +
Sbjct: 440 MYGQQIVQMK--QELIRQHMAQMEEMKTRHKGEMENALRSYS-----------NITVNED 486
Query: 359 QLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLD 418
Q+ L + E L +N K+E+ ++ L++ L D
Sbjct: 487 QIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQ--------------LED 532
Query: 419 MIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEP 478
++EE + ++ I R + + NE HK + E + + S S +E
Sbjct: 533 LVEELSFSREQ-------IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKEL 585
Query: 479 E-------SNVSVDQEIDAEEVNSV--------QTAVKNLATAFMIIHHPE 514
E +N + E+ +E N+V + ++ L T + H E
Sbjct: 586 ELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEE 636
Score = 57.8 bits (138), Expect = 3e-08
Identities = 109/503 (21%), Positives = 201/503 (39%), Gaps = 81/503 (16%)
Query: 36 QDSPTPVQPPEKEASVHPDISEELNRQLEDIINTYGSAASTAGKEGSARASEQPENAESP 95
QD+ + + ++E + + L RQLED++ + +E RA + ES
Sbjct: 503 QDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS-----REQIQRARQTIAEQESK 557
Query: 96 DNEDGDCEETTEEAGREPVASGEPPTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKL 155
NE T E+ E V++ E E E K L+ L KE N ++ + +
Sbjct: 558 LNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAES 617
Query: 156 QTPEE---KFDFLFKKYAELLD-------EHRTEQKKLK----LLQKKQVQ--------- 192
Q E + LF EL EHR +KLK + K+Q+
Sbjct: 618 QEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQK 677
Query: 193 ---IQKEKDQLQGEHSRAILARSKLESL---------------CRELQRHNKTLKEEALQ 234
+Q EKD L + ++ IL SKL+ L ELQ+ + L++E +
Sbjct: 678 IETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKE 737
Query: 235 RAREEEE------KRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLK--SII 286
+ E+E K + + + D+Q + Q N L E L + LK + +
Sbjct: 738 KGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPV 797
Query: 287 DQYELREEHLDKIFKHRE--LQQKLVDAKLEQAQEMMKEA----EERHKR-------EKE 333
Q E R LD I + + +K ++ +E+ +++ ++ EE K+ EK
Sbjct: 798 SQEE-RLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKN 856
Query: 334 YLLNQAA---EWKLQAKVLKEQETVLQAQLTLYSGRFEEFQ----------STLTKSNEV 380
+ +N E+ KV + E Q Y + + +T+ + V
Sbjct: 857 FEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSV 916
Query: 381 FATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRL 440
F K + +T + + +EKDT + E + L++ + + +++ + +I L
Sbjct: 917 FDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFL 976
Query: 441 ENLCRALQEERNELHKKIRDAEI 463
++L++E+ ++ + R+ EI
Sbjct: 977 NEEVKSLKQEKEQVSLRCRELEI 999
Score = 47.4 bits (111), Expect = 4e-05
Identities = 114/638 (17%), Positives = 250/638 (39%), Gaps = 97/638 (15%)
Query: 122 VKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQT----PEEKFDFLFKKYAELLDEHR 177
++ + + +++EK + E LL+++ PE + + + +D
Sbjct: 2135 LQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKE 2194
Query: 178 TEQKKLK-LLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKE--EALQ 234
E L+ L++ + +++ + +++Q H + + + + + +EL++ NK K+ E L
Sbjct: 2195 KEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLG 2254
Query: 235 RAREEEEKRKEITSH-----FQSTLTDIQGQIEQQSERNMKLCQE------NTELAEK-- 281
A +E + H F + + + +I+Q +E+ KL Q+ N + EK
Sbjct: 2255 LAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNE 2314
Query: 282 -LKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAA 340
++ + Q E + + ++RE + + ++ +E+ Q+ + ++ L +A
Sbjct: 2315 LIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEAD 2374
Query: 341 EWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEK 400
K Q V+ ++ L+ Q+ + ++ L ++N QE+ ++ + +EK
Sbjct: 2375 SLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEK 2434
Query: 401 DTA----TWKARFENCNK---ALLDMIEEKALRAKEYECFV---------------MKIG 438
+ + ++ +K L ++ E AL++ E + + ++
Sbjct: 2435 IQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLL 2494
Query: 439 RLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEPESNVSVDQEIDAE------- 491
+LE+ A E + +K+I+D + +Q Q ++ + V++ + ++ +
Sbjct: 2495 QLESTVSAKDLELTQCYKQIKDMQ-----EQGQFETEMLQKKIVNLQKIVEEKVAAALVS 2549
Query: 492 --EVNSVQTAVKNLATAFMIIHHPESTPHQ--SKETQPEIGSS---------------QE 532
++ +VQ K I PE T Q ++ + E+GS E
Sbjct: 2550 QIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVE 2609
Query: 533 SADAALKEPEQPPLIPSRDSESPLPPLTPQAEAEGGSDAEPPSKASNSPAGL-------- 584
+ + E EQ + E L Q EG + + SP +
Sbjct: 2610 MHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTE 2669
Query: 585 --------GAETQCEGL---PVGAQADQASWKPEAEASGQ--APQAPTEASLQKMEADVP 631
G + E L V +A+ AS+K +AE + + SLQK + V
Sbjct: 2670 LFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVR 2729
Query: 632 APACAAEEHVAAMVPACEPSRQPPRAAA--EELPVGAS 667
A+E ++ + E Q + A E LP+ S
Sbjct: 2730 DHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLS 2767
Score = 45.8 bits (107), Expect = 1e-04
Identities = 69/313 (22%), Positives = 125/313 (39%), Gaps = 34/313 (10%)
Query: 189 KQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITS 248
+++ +++E++ + + +S E+Q ++K+ A + +E+ K + +
Sbjct: 3096 RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATE-LQEQLSSEKMVVA 3154
Query: 249 HFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHL-DKIFKHRELQQ 307
+S L + ++E + K +E ++K D+ L + L + K RELQ
Sbjct: 3155 ELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQW 3214
Query: 308 KLVDAKLEQAQEMMKEAEERHKREKEYL---LNQAAEWKLQAKVLKEQETVL-------- 356
L E+ + + +EER K E E L L + LQ +L EQ+ L
Sbjct: 3215 AL-----EKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKI 3269
Query: 357 -------QAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKAR- 408
AQL+ GR E Q L +D+ + +L+ T ++R
Sbjct: 3270 ESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRP 3329
Query: 409 ---FENCNKALLDMIEEKALRAKEY--ECFVMKIGRLENLCRALQEERNELHKKIRDAEI 463
E+ K L +EEK R E E K+ L+ R E+ ++H+K E
Sbjct: 3330 PLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT--RQQMEKDRQVHRKTLQTE- 3386
Query: 464 SEKDDQSQHNSDE 476
E + + Q E
Sbjct: 3387 QEANTEGQKKMHE 3399
Score = 43.5 bits (101), Expect = 6e-04
Identities = 74/372 (19%), Positives = 151/372 (40%), Gaps = 43/372 (11%)
Query: 150 QNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAIL 209
QN N+ Q E+ F K+ + + E ++L ++ +QK ++L +
Sbjct: 1686 QNGNENQGEVEEQTFKEKEL-----DRKPEDVPPEILSNERYALQKANNRLLKILLEVVK 1740
Query: 210 ARSKLESLCRE-----LQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTD-----IQG 259
+ +E L R +K+ +L E E K + +TD G
Sbjct: 1741 TTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSG 1800
Query: 260 QIEQQSERNM--KLCQENTELAEKL-KSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQ 316
+++ NM K+ +E TEL+++L +S E+ E+ + + Q V+ LE
Sbjct: 1801 SDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA 1860
Query: 317 AQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTK 376
E + E + E + + + + LK QE L+ +L S E+ L+K
Sbjct: 1861 ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEE-LRERLHEESRAREQLAVELSK 1919
Query: 377 SNEVF-------ATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKE 429
+ V F++++ + T + +LE++ R + + EE+ L +++
Sbjct: 1920 AEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQ 1979
Query: 430 YECFVMKIG----------------RLENLCRALQEERNELHKKIRDAEISEKDDQSQHN 473
E + G +LE C+A ++ R++L K+++ EI ++ S+
Sbjct: 1980 KEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQA-EKVRDDLQKQVKALEIDVEEQVSRFI 2038
Query: 474 SDEEPESNVSVD 485
E+ ++ +D
Sbjct: 2039 ELEQEKNTELMD 2050
Score = 40.8 bits (94), Expect = 0.004
Identities = 52/210 (24%), Positives = 101/210 (48%), Gaps = 35/210 (16%)
Query: 123 KEPVSNKEQKLEKKIL---------KGLGKEANLLMQNLN-KLQTPEEKFDFLFKKYAEL 172
K+ ++ +QK+E + + +G E +L+++ +++ D + +A+L
Sbjct: 3259 KQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQL 3318
Query: 173 LDEHRTEQKKLKLLQKKQV-QIQKEKDQLQGEHSRAI-----LARSKLESLC------RE 220
T Q + L + + ++QK QL+ +HSR + + KL+SL ++
Sbjct: 3319 QSSDGTGQSRPPLPSEDLLKELQK---QLEEKHSRIVELLNETEKYKLDSLQTRQQMEKD 3375
Query: 221 LQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAE 280
Q H KTL+ E Q A E +K+ QS + D+Q Q+E++ ++ KL E +
Sbjct: 3376 RQVHRKTLQTE--QEANTEGQKKMH---ELQSKVEDLQRQLEEKRQQVYKLDLE----GQ 3426
Query: 281 KLKSIIDQYELRE-EHLDKIFKHRELQQKL 309
+L+ I+ +++ +E E +K R L Q L
Sbjct: 3427 RLQGIMQEFQKQELEREEKRESRRILYQNL 3456
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 72.0 bits (175), Expect = 2e-12
Identities = 110/506 (21%), Positives = 211/506 (41%), Gaps = 60/506 (11%)
Query: 42 VQPPEKEASVHPDISEELNRQLEDIINTYGSAASTAGKEGSARASE----QPENAESPDN 97
+Q K+ H EE+ +++ I+ S K+ E Q + + N
Sbjct: 1501 LQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN 1560
Query: 98 EDGDCEETTEEAGREPVASGEPPTVKEPVSNKEQKL------------EKKILKGLGKEA 145
ED + E E +K V++++Q++ E +L+G +A
Sbjct: 1561 EDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQA 1620
Query: 146 NLLMQNLNKLQTPE--EKFDFLFKKYAELLDEH---------RTEQKKLKLLQKKQVQIQ 194
+Q +L E EK + + ++ LL+E + ++K +L KQ +I+
Sbjct: 1621 KADLQEALRLGETEVTEKCNHI-REVKSLLEELSFQKGELNVQISERKTQLTLIKQ-EIE 1678
Query: 195 KEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITS------ 248
KE++ LQ + +++L+++ LQ N L+ LQ + E K +
Sbjct: 1679 KEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKL 1738
Query: 249 ---HFQSTLTDIQGQIEQQS---ERNMKLCQENTELAEKLKSIIDQYELREEHLDK---I 299
+ Q +G+IE Q ER+ + + T + L+S ++ +E L + I
Sbjct: 1739 ELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDI 1798
Query: 300 FKHRELQQKLVDAKLEQAQEMMK---EAEERHKREKEYLLNQAAEWKLQAKVLKEQETVL 356
++ + Q K V A E+ +M + E E + R+ + L+Q KL L + +
Sbjct: 1799 WEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLS---LHNDISAM 1855
Query: 357 QAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTK-------KMKKLEKDTATWKARF 409
Q QL Q L + KQ++ TTK + +L+KD + W RF
Sbjct: 1856 QQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRF 1915
Query: 410 ENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQ 469
E+C K ++ + E E +K+ + E + + LQ+ER K+ ++++ K+ Q
Sbjct: 1916 EDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQ 1975
Query: 470 SQ---HNSDEEPESNVSVDQEIDAEE 492
Q +D++ + + + + + AEE
Sbjct: 1976 HQLEKELTDQKSKLDQVLSKVLAAEE 2001
Score = 60.8 bits (146), Expect = 4e-09
Identities = 95/406 (23%), Positives = 181/406 (44%), Gaps = 57/406 (14%)
Query: 154 KLQTPEEKFDFLFKKYAELLDE-HRTEQKKLKLLQK-KQVQIQKEKDQLQ--GEHSRAIL 209
+L+ E+K + +EL DE + EQ+ L+ ++ KQ++ E QL+ E + +L
Sbjct: 438 QLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLE---EAIQLKKISEAGKDLL 494
Query: 210 ARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNM 269
+ L LQ NK L++EAL + E++++EI Q + D+Q I+ ++
Sbjct: 495 YKQ----LSGRLQLVNK-LRQEALDLELQMEKQKQEIAGK-QKEIKDLQIAIDSLDSKDP 548
Query: 270 K---LCQENTELAEKLKSIIDQYELREEHLDKIFKH--------RELQQKLVDAKLEQAQ 318
K + + + ++L + QY+ E LD+I ++L+++L + ++ +
Sbjct: 549 KHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANE 608
Query: 319 EMMKEAEERHKREKEYL---LNQAAEWKLQAKVLK-EQETVLQAQLTLYSGR-------- 366
+ K+ E +EYL QA + + + + L+ E+ET+LQ + R
Sbjct: 609 ALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAM 668
Query: 367 --------FEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLE-----KDTATWKARFENCN 413
E +S L + +EV A+ +Q + +LE +D + + E
Sbjct: 669 DAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEK 728
Query: 414 KALLDMIEEKALRA---KEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQS 470
L +E+ AL+A KE + +G+ + ++E +ELH K++ + + +
Sbjct: 729 VTRLTQLEQSALQAELEKERQALKNALGKAQ-FSEEKEQENSELHAKLKHLQ-DDNNLLK 786
Query: 471 QHNSDEEPESNVSVDQEIDAEEVNSVQTAVK---NLATAFMIIHHP 513
Q D + N VD + EEV + ++ L T M IH P
Sbjct: 787 QQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSP 832
Score = 56.2 bits (134), Expect = 1e-07
Identities = 76/348 (21%), Positives = 144/348 (41%), Gaps = 43/348 (12%)
Query: 159 EEKFDFLFKKYAELL-------DEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILAR 211
+EK D KK A+ + + EQ L+ L+ ++Q+E DQL +
Sbjct: 1793 QEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRD-------- 1844
Query: 212 SKLESLCRELQRHNK-TLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMK 270
+L HN + ++ LQ RE +E ++ Q L + + ++
Sbjct: 1845 --------KLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDV 1896
Query: 271 LCQENTELAEKLKSIIDQYE-LREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERHK 329
L E T L + + +++E ++E K + + LQ ++ + KL+ Q+ M + +
Sbjct: 1897 LLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKE 1956
Query: 330 REKEYLLNQAAEWKLQAK--VLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQE 387
RE E E KL+ LKEQ+ L+ +LT + ++ S + + E T ++E
Sbjct: 1957 RESE-------ESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEE 2009
Query: 388 MDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRAL 447
+ + LEK + K + + L++ E KE + L N
Sbjct: 2010 ----ERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRN---QF 2062
Query: 448 QEERNELHKKIRDAEISEKDDQSQ--HNSDEEPESNVSVDQEIDAEEV 493
ER + K++ + + K +SQ N E+ + N + +E+ E+
Sbjct: 2063 LTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIEL 2110
Score = 32.0 bits (71), Expect = 1.9
Identities = 81/398 (20%), Positives = 161/398 (40%), Gaps = 88/398 (22%)
Query: 181 KKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEE 240
++ L + ++++ EK ++ E ++ R LE + + + NK+LKEEA+ + + E
Sbjct: 265 ERFSLEEVERLERDLEKKMIETEELKSKQTRF-LEEI-KNQDKLNKSLKEEAMLQKQSCE 322
Query: 241 EKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIF 300
E + ++ + +N L Q+ EL + QYEL +
Sbjct: 323 ELKSDLNT------------------KNELLKQKTIELTRACQK---QYELEQ------- 354
Query: 301 KHRELQQKLVDAKLE-------QAQEMMKEAEE-------RHKRE----KEYLLNQAAEW 342
EL +DAK E + E+ K +E R+KR + Y+++ A
Sbjct: 355 ---ELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAV 411
Query: 343 KLQAKVLKEQ----------ETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTT 392
+++ EQ T L QL + Q+ L++ ++ +Q++ + T
Sbjct: 412 QIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRAT 471
Query: 393 KKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERN 452
++ K+LE+ A + K LL L+ V K+ R E L LQ E+
Sbjct: 472 EEFKQLEE--AIQLKKISEAGKDLLYKQLSGRLQ------LVNKL-RQEALDLELQMEKQ 522
Query: 453 E-----LHKKIRDAEIS-----EKDDQSQHNSDEEPESNVSVDQEIDAEEVNSVQTAVKN 502
+ K+I+D +I+ KD + H ++ +D I ++ +++ +
Sbjct: 523 KQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLD--IMNKQYQQLESRLDE 580
Query: 503 LATAFMIIHHPESTPHQSKETQPEIGSSQESADAALKE 540
I+ + K+ + ++ Q +A+ ALK+
Sbjct: 581 ------ILSRIAKETEEIKDLEEQLTEGQIAANEALKK 612
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 70.9 bits (172), Expect = 4e-12
Identities = 99/484 (20%), Positives = 201/484 (41%), Gaps = 49/484 (10%)
Query: 3 ANHSEQLSAERQSTPPGDSSSLPSHNGLEKEDGQDSPTPVQ----PPEKEASVHPDISEE 58
A EQL+ T P ++ + +G + T PE E E
Sbjct: 61 AEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDEQKASHQHQEA 120
Query: 59 LNRQLEDIINTYGSAASTAGKEGSARASEQPENAESPDNEDGDCEETTEEAGREPVASGE 118
L R+LE ++T T K A ++A +G+ + +GE
Sbjct: 121 LRRELEAQVHTI--RILTCQKTELQMALYYSQHAVK--QLEGEARDLISRLHDSWKFAGE 176
Query: 119 PPTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRT 178
V+ +++K ++ I + L KE + L L Y + +
Sbjct: 177 LEQALSAVATQKKKADRYI-EELTKERDALSLEL----------------YRNTITDEEL 219
Query: 179 EQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRARE 238
++K KL +K Q+ ++ EK ++Q ++ L R+L+R L ++ LQ E
Sbjct: 220 KEKNAKLQEKLQL-VESEKSEIQ----------LNVKELKRKLERAKLLLPQQQLQA--E 266
Query: 239 EEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDK 298
+ KE+ QS +Q Q+E+ N +L Q+ E + + I ++E + + ++
Sbjct: 267 ADHLGKEL----QSVSAKLQAQVEENELWN-RLNQQQEEKMWRQEEKIQEWEEKIQEQEE 321
Query: 299 IFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQA 358
+ +E + + + K+ + +EMM E EE+ +R++E + + + + Q +++ E+E ++
Sbjct: 322 KIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 381
Query: 359 QLTLYSGRFEEFQSTLTKSNE-----VFATFKQEMDKTTKKMKKLEKDTATWKARFENCN 413
Q + + E+ + K +E +QE +K ++ K+ E++ W+ +
Sbjct: 382 QEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE 441
Query: 414 KALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHN 473
+ +EK + +E + + R E R QEE +KI + E + + H
Sbjct: 442 QEEKIREQEKKMWRQEEKIHEQEKIREEEK-RQEQEEMWRQEEKIHEQEEIWRQKEKMHE 500
Query: 474 SDEE 477
+E+
Sbjct: 501 QEEK 504
Score = 66.2 bits (160), Expect = 9e-11
Identities = 64/314 (20%), Positives = 154/314 (49%), Gaps = 23/314 (7%)
Query: 87 EQPENAESPDNEDGDCEETTEEAGREPVASGEPPTVKEPVSNKEQKLEKKILKGLGKEAN 146
EQ E + + EE E +E + E +E + +E+K+ ++ + + ++
Sbjct: 441 EQEEKIREQEKKMWRQEEKIHE--QEKIREEEKRQEQEEMWRQEEKIHEQ--EEIWRQKE 496
Query: 147 LLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSR 206
+ + K++ EEK +K E ++ R +++K+ ++K +E++++ E +
Sbjct: 497 KMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKI----REQEEMWREEEK 552
Query: 207 AILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSE 266
+ + K+ + ++ +K ++E R +EE+ R+E I+ Q E++ E
Sbjct: 553 -MHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQE---------EKIREQEEKRQE 602
Query: 267 RNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEE 326
+ K+ ++ ++ E+ + I +Q E E +KI + E+ Q+ + K+ + +E M E EE
Sbjct: 603 QEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQ-EEKMGEQEEKMCEQEE 661
Query: 327 RHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQ 386
+ + ++E + Q + + Q K ++EQE ++ Q + +E + + + E ++
Sbjct: 662 KMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEM----MQEQEEKMWEQEEKMCEQEE 717
Query: 387 EMDKTTKKMKKLEK 400
+M + +KM++ E+
Sbjct: 718 KMQEQEEKMRRQEE 731
Score = 62.8 bits (151), Expect = 1e-09
Identities = 86/446 (19%), Positives = 194/446 (43%), Gaps = 56/446 (12%)
Query: 79 KEGSARASEQPENAESPDNEDGDCEETTEEAGREPVASGEPPTVKEPVSNKEQKLEKKIL 138
+E + EQ E + + EE E + E KE +++++ +
Sbjct: 317 QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKE 376
Query: 139 KGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKD 198
+ + ++ ++ + K++ EEK K + +E R E++K++ +K+Q Q K
Sbjct: 377 EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ--EEKRQEEEKIREQEKRQEQEAKMWR 434
Query: 199 QLQGEHSRAILARSKLESLCRELQR-HNKTLKEEALQRAREEEEKRKEITSHFQSTLTDI 257
Q + + R + + + R+ ++ H + E +R +EE R+E H Q +
Sbjct: 435 QEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQ 494
Query: 258 QGQIEQQSER----NMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHREL-------- 305
+ ++ +Q E+ K+ ++ ++ E+ + I +Q E +KI + E+
Sbjct: 495 KEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMH 554
Query: 306 -QQKLVDAKLEQAQE--------MMKEAEERHKREKEYLLNQAAE--------WKLQAKV 348
Q+K+ + + Q QE ++E EE+ R++E + Q + WK + K+
Sbjct: 555 EQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKI 614
Query: 349 LKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKM-----KKLEKDTA 403
+EQE +Q Q + E + + + E+ +++M + +KM K E++
Sbjct: 615 -REQEEKIQEQ----EEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEET 669
Query: 404 TWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKI--RDA 461
W+ + I E+ + +E E KI E + + +E+ E +K+ ++
Sbjct: 670 MWRQE---------EKIREQEKKIREQE---EKIREQEEMMQEQEEKMWEQEEKMCEQEE 717
Query: 462 EISEKDDQSQHNSDEEPESNVSVDQE 487
++ E++++ + ++ E V + Q+
Sbjct: 718 KMQEQEEKMRRQEEKMWEQEVRLRQQ 743
Score = 41.6 bits (96), Expect = 0.002
Identities = 46/214 (21%), Positives = 102/214 (47%), Gaps = 20/214 (9%)
Query: 107 EEAGREPVASGEPPTVKEPVSNKEQ-----KLEKKILKG---LGKEANLLMQNLNKLQTP 158
EE RE E + E +EQ + E+KI + + ++ + + K Q
Sbjct: 544 EEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQ 603
Query: 159 EEKFDFLFKKYAELLDEHRTEQKKLKLLQKK---QVQIQKEKDQLQGEHSRAILARS-KL 214
EEK +K E ++ + +++K++ ++K Q ++ +E+++ GE + + K+
Sbjct: 604 EEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKM 663
Query: 215 ESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQE 274
+ + R + ++E+ ++ RE+EEK +E Q + +Q Q E+ E+ K+C++
Sbjct: 664 QEQEETMWRQEEKIREQE-KKIREQEEKIRE-----QEEM--MQEQEEKMWEQEEKMCEQ 715
Query: 275 NTELAEKLKSIIDQYELREEHLDKIFKHRELQQK 308
++ E+ + + Q E E ++ + E Q+
Sbjct: 716 EEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 70.5 bits (171), Expect = 5e-12
Identities = 85/415 (20%), Positives = 182/415 (43%), Gaps = 46/415 (11%)
Query: 79 KEGSARASEQPE-NAESPDNE---DGDCEETTEEAGREPVASGEPPTVKEPVSNKEQKLE 134
KE + RA E+ E NAE + + +C E ++ + + K NK + L
Sbjct: 923 KEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLT 982
Query: 135 KKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQ 194
++ + GL + L + LQ + + + LD+ + E+ K+ +L K + +++
Sbjct: 983 EE-MAGLDETIAKLSKEKKALQ----------ETHQQTLDDLQAEEDKVNILTKAKTKLE 1031
Query: 195 KEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTL 254
++ D L+G + R LE R+L+ K +E + ++++ +++ + +
Sbjct: 1032 QQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKK-EFEI 1090
Query: 255 TDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKL 314
+++ +IE + ++L ++ EL +++ + ++ E K E Q+ + +L
Sbjct: 1091 SNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAK----AEKQRSDLSREL 1146
Query: 315 EQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTL 374
E+ E ++EA + E LN+ E + Q +E LQ + + + R
Sbjct: 1147 EEISERLEEAGGATSAQVE--LNKKREAEFQKLRRDLEEATLQHEAMVAALR-------- 1196
Query: 375 TKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFV 434
K + A +++D + +KLEK+ + K ++ L E +AK
Sbjct: 1197 KKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDD-----LSSNAEAISKAK------ 1245
Query: 435 MKIGRLENLCRALQEERNELHKKIRDAE--ISEKDDQSQHNSDEEPESNVSVDQE 487
G LE +CR+L+++ +EL K + + I++ Q E E + +D++
Sbjct: 1246 ---GNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEK 1297
Score = 60.1 bits (144), Expect = 7e-09
Identities = 79/351 (22%), Positives = 165/351 (47%), Gaps = 34/351 (9%)
Query: 152 LNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILAR 211
L K E++ + +++ + DE + K K L++K V + KEK+ LQ + +
Sbjct: 842 LLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSL 901
Query: 212 SKLESLCRELQRHNKTLK---EEALQRAREEEEKRKEITS---HFQSTLTDIQGQIEQQS 265
+ E C +L ++ L+ +E +RA EEEE E+T+ + ++++ I+
Sbjct: 902 ADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLE 961
Query: 266 ERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAE 325
K+ +E K+K++ ++ +E + K+ K ++ Q+ L+ Q AE
Sbjct: 962 LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQ-----AE 1016
Query: 326 ERHKREKEYLLNQAAEWKLQAKV-----LKEQETVLQAQLTLYSGRFEEFQSTLTKSNEV 380
E +K +L + A+ KL+ +V EQE L+ L + E +S
Sbjct: 1017 E----DKVNILTK-AKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMD 1071
Query: 381 FATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIG-- 438
KQ++D +K++K E + + ++ E+ +A+ +++K KE + + ++G
Sbjct: 1072 MENDKQQLD---EKLEKKEFEISNLISKIED-EQAVEIQLQKK---IKELQARIEELGEE 1124
Query: 439 -RLENLCRA-LQEERNELHKKIRDAEISEKDDQSQHNSDEEPESNVSVDQE 487
E RA +++R++L +++ EISE+ +++ + + E N + E
Sbjct: 1125 IEAERASRAKAEKQRSDLSRELE--EISERLEEAGGATSAQVELNKKREAE 1173
Score = 58.2 bits (139), Expect = 3e-08
Identities = 76/381 (19%), Positives = 165/381 (43%), Gaps = 24/381 (6%)
Query: 131 QKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQ 190
QK + + L K N+ ++L++L+T + L ++ ++L ++ K++ L+K +
Sbjct: 1474 QKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIK 1533
Query: 191 VQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHF 250
Q+++EK ++Q A + E +Q +K E ++ E++E+ ++ +
Sbjct: 1534 KQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNH 1593
Query: 251 QSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLV 310
+ +Q ++ + ++ + + +K++ +++ E++ H +++ +
Sbjct: 1594 TRVVETMQSTLDAE----IRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNT 1649
Query: 311 DAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQL--TLYSGRFE 368
L++ Q + +A R +E L Q A + +A +L+ + L A L T S +
Sbjct: 1650 QGILKETQLHLDDA----LRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIA 1705
Query: 369 EFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFE-------NCNKALLDMIE 421
E Q L S V Q K KKLE D + ++ E N + I
Sbjct: 1706 E-QELLDASERVQLLHTQNTSLINTK-KKLENDVSQLQSEVEEVIQESRNAEEKAKKAIT 1763
Query: 422 EKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEI-----SEKDDQSQHNSDE 476
+ A+ A+E + LE + + L++ +L ++ +AE +K Q
Sbjct: 1764 DAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVR 1823
Query: 477 EPESNVSVDQEIDAEEVNSVQ 497
E E V +Q+ +AE V ++
Sbjct: 1824 ELEGEVENEQKRNAEAVKGLR 1844
Score = 46.2 bits (108), Expect = 1e-04
Identities = 50/246 (20%), Positives = 111/246 (45%), Gaps = 11/246 (4%)
Query: 154 KLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSK 213
+L E + + L + EL ++ K+ +++ + + L +++ I + K
Sbjct: 1673 QLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKK 1732
Query: 214 LESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQ 273
LE+ +LQ EE +Q +R EEK K+ + +++ EQ + +++ +
Sbjct: 1733 LENDVSQLQSE----VEEVIQESRNAEEKAKKAITDAAMMAEELKK--EQDTSAHLERMK 1786
Query: 274 ENTELAEK-LKSIIDQYE-LREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEE---RH 328
+N E K L+ +D+ E L + K + E + + ++ ++E Q+ EA + +H
Sbjct: 1787 KNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKH 1846
Query: 329 KREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEM 388
+R + L Q E + L++ LQA++ Y + EE + + F + E+
Sbjct: 1847 ERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHEL 1906
Query: 389 DKTTKK 394
++ ++
Sbjct: 1907 EEAEER 1912
Score = 43.5 bits (101), Expect = 6e-04
Identities = 44/225 (19%), Positives = 101/225 (44%), Gaps = 21/225 (9%)
Query: 127 SNKEQKLEKKILKGLGKEANLL-MQNLNKLQTP---EEKFDFLFKKYAELLDEHRTEQKK 182
+ + +K+ ++ L + LL QN + + T E L + E++ E R ++K
Sbjct: 1698 TERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEK 1757
Query: 183 LKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEK 242
K + +E + Q + + LE ++LQ ++ AL+ +++ +K
Sbjct: 1758 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK 1817
Query: 243 RKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKH 302
++ + +++G++E + +RN + + + ++K + Q EE + +
Sbjct: 1818 -------LEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQ---TEEDRKNVLRL 1867
Query: 303 RELQQKLVDAKLEQAQEMMKEAEERHK------REKEYLLNQAAE 341
++L KL AK++ + +EAEE+ R+ ++ L +A E
Sbjct: 1868 QDLVDKL-QAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEE 1911
Score = 37.7 bits (86), Expect = 0.035
Identities = 50/208 (24%), Positives = 91/208 (43%), Gaps = 37/208 (17%)
Query: 124 EPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKL 183
E V + + E+K K + +A ++ + L K Q + + K E + +
Sbjct: 1745 EEVIQESRNAEEKAKKAI-TDAAMMAEELKKEQDTSAHLERMKKNL-----EQTVKDLQH 1798
Query: 184 KLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQ---RHNKTLKEEALQRAREEE 240
+L + +Q+ ++ K Q+Q KLE+ REL+ + + EA++ R+ E
Sbjct: 1799 RLDEAEQLALKGGKKQIQ-----------KLEARVRELEGEVENEQKRNAEAVKGLRKHE 1847
Query: 241 EKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLD-KI 299
+ KE+T Q E+ + ++L +L K+KS Q E EE + +
Sbjct: 1848 RRVKELTY-----------QTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANL 1896
Query: 300 FKHRELQQKLVDAKLEQAQEMMKEAEER 327
K R+LQ +L E+A+E AE +
Sbjct: 1897 SKFRKLQHEL-----EEAEERADIAESQ 1919
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 70.1 bits (170), Expect = 6e-12
Identities = 88/415 (21%), Positives = 176/415 (42%), Gaps = 55/415 (13%)
Query: 123 KEPVSNKEQKLEKKILKGLGKEANLLMQN----LNKLQTPEEKFDFLFKKYAELLDEHRT 178
+E +E + ++ +GLG E L L L+T + + L ++ ++L D+
Sbjct: 1508 QEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSL 1567
Query: 179 EQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRARE 238
K ++ L+K + ++ EK ++Q A A E+ +Q +K E ++ E
Sbjct: 1568 SGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAE 1627
Query: 239 EEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDK 298
++E+ + + Q + +Q ++ ++ E L +K++ ++ EL+ H +
Sbjct: 1628 KDEECANLRRNHQRAVESLQASLDAETRAR----NEALRLKKKMEGDLNDLELQLGHATR 1683
Query: 299 IFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQA 358
+ +L+ A+L+ EE+ R++E L AAE QA+ L+ + ++L A
Sbjct: 1684 QATEAQAATRLMQAQLK---------EEQAGRDEEQRL--AAELHEQAQALERRASLLAA 1732
Query: 359 QLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKM--------------KKLEKDTAT 404
+L EE ++ L + +QE+ + T+++ KKLE D A
Sbjct: 1733 EL-------EELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQ 1785
Query: 405 WKARFE-------NCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKK 457
E + I + A+ A+E + LE + + L++ EL +
Sbjct: 1786 LSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQAR 1845
Query: 458 IRDAEIS-----EKDDQSQHNSDEEPESNVSVDQEIDAEEVNSV---QTAVKNLA 504
+ +AE + +K Q E E+ + +Q+ AE + V + VK LA
Sbjct: 1846 LEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELA 1900
Score = 53.5 bits (127), Expect = 6e-07
Identities = 158/688 (22%), Positives = 259/688 (37%), Gaps = 102/688 (14%)
Query: 26 SHNGLEKEDGQDSPTPVQPPEKEASVHPDISEELNRQLEDIINTYGSAASTAGKEGSARA 85
S L ED Q +Q KE +EEL +LE E +ARA
Sbjct: 1137 SQLSLRVEDEQLLGAQMQKKIKELQAR---AEELEEELE--------------AERAARA 1179
Query: 86 SEQPENAESPDNEDGDCEETTEEAGREPVASGEPPTVKEP-VSNKEQKLEKKILKGLGKE 144
+ + AE+ E + E EEAG E +E + ++LE+ L+
Sbjct: 1180 RVEKQRAEAA-RELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATV 1238
Query: 145 ANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEH 204
A L + E+ D L R QK L+K++ +++ E D L
Sbjct: 1239 AALRRKQAEGAAELGEQVDSL----------QRVRQK----LEKEKSELRMEVDDLAANV 1284
Query: 205 SRAILARSKLESLCR--ELQRHNKTLKEEALQR----AREEEEKRKEITSHFQSTLTDIQ 258
A++ E LCR E Q +K E LQR A + + + + L + +
Sbjct: 1285 ETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKE 1344
Query: 259 GQIEQQSERNMKLCQENTELAEKL------KSII---------DQYELREEHLDKIFKHR 303
I Q S Q EL +L KS + D LRE+H ++
Sbjct: 1345 CLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQA 1404
Query: 304 ELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLY 363
ELQ+ L A E AQ K + +R +E + A+ KL ++ + +E V A
Sbjct: 1405 ELQRLLSKANAEVAQWRSKYEADAIQRTEEL---EEAKKKLALRLQEAEEGVEAANAKCS 1461
Query: 364 SGRFEEFQSTL-TKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEE 422
S E+ + L T+S +V E+++ T L+K + E + +M E
Sbjct: 1462 S--LEKAKLRLQTESEDV----TLELERATSAAAALDKKQRHLERALEERRRQEEEMQRE 1515
Query: 423 KALRAKEYECFVMKIGRL----ENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEP 478
+E ++ RL E AL+ + E +K +++ EIS+ DQ +
Sbjct: 1516 LEAAQRESRGLGTELFRLRHGHEEALEALETLKRE-NKNLQE-EISDLTDQVSLSGKSIQ 1573
Query: 479 ESNVSVDQEIDAEEVNSVQTAVKNLATAFMIIHHPESTPHQSKETQPEIGSSQESADAAL 538
E + ++ E+ + +Q A++ A E ++ Q E+ + D L
Sbjct: 1574 ELE-KTKKALEGEK-SEIQAALEEAEGAL------ELEETKTLRIQLELSQVKAEVDRKL 1625
Query: 539 KEPEQPPLIPSRDSESPLPPLTPQAEAEGGSDAEPPSKASNSPAGLGAETQCEG------ 592
E ++ R+ + + L +AE ++A N L + + EG
Sbjct: 1626 AEKDEECANLRRNHQRAVESLQASLDAE--------TRARNE--ALRLKKKMEGDLNDLE 1675
Query: 593 LPVGAQADQASWKPEAEASGQAPQAPTEASLQKMEADVPAPACAAEEHVAAMVPACEPSR 652
L +G QA+ EA+A+ + QA + + + AAE H A A E
Sbjct: 1676 LQLGHATRQAT---EAQAATRLMQAQLKEEQAGRDEE---QRLAAELHEQAQ--ALERRA 1727
Query: 653 QPPRAAAEELPVGASAGPQPRNVADTNL 680
A EEL G + R +A+ L
Sbjct: 1728 SLLAAELEELRAALEQGERSRRLAEQEL 1755
Score = 52.8 bits (125), Expect = 1e-06
Identities = 62/275 (22%), Positives = 123/275 (44%), Gaps = 13/275 (4%)
Query: 140 GLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQ 199
G +E L + + Q E + L + EL ++ +L +++ ++ + +
Sbjct: 1705 GRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNL 1764
Query: 200 LQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQG 259
L +++ + + KLE+ +L EEA Q RE EEK K+ + +++
Sbjct: 1765 LHSQNTGLLNQKKKLEADLAQLSGE----VEEAAQERREAEEKAKKAITDAAMMAEELKK 1820
Query: 260 QIEQQSE-RNMKLCQENT--ELAEKLKSIIDQYELR--EEHLDKI-FKHRELQQKLVDAK 313
+ + + MK E T EL +L+ +Q LR ++ + K+ K REL+ +L DA+
Sbjct: 1821 EQDTSAHLERMKKTLEQTVRELQARLEEA-EQAALRGGKKQVQKLEAKVRELEAEL-DAE 1878
Query: 314 LEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQST 373
++ E +K + +R KE L QA E + +++ LQ+++ Y +FEE +
Sbjct: 1879 QKKHAEALKGVRKHERRVKE-LAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQ 1937
Query: 374 LTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKAR 408
+ + + E+D ++ E +AR
Sbjct: 1938 ANTNLAKYRKAQHELDDAEERADMAETQANKLRAR 1972
Score = 50.8 bits (120), Expect = 4e-06
Identities = 89/402 (22%), Positives = 165/402 (41%), Gaps = 40/402 (9%)
Query: 132 KLEKKILKGLGKEANLLMQNLNK--LQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKK 189
+ E + L+G A Q L + + +EK D + AE D +++ LL K
Sbjct: 902 RAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQ-DNLADAEERCHLLIKS 960
Query: 190 QVQIQKEKDQLQG-----EHSRAILA--RSKLESLCRELQRHNKTLKEEALQRAREEEEK 242
+VQ++ + +L E A LA R KLE C EL++ LK L A+ E+E
Sbjct: 961 KVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLK---LTLAKAEKE- 1016
Query: 243 RKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKH 302
K+ T + LT+ +++ R L +E L E + + + E+ + + K
Sbjct: 1017 -KQATENKVKNLTEEMAALDESVAR---LTKEKKALQEAHQQALGDLQAEEDRVSALTKA 1072
Query: 303 R-ELQQKLVDAKLEQAQE-MMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQL 360
+ L+Q++ D + QE ++ ER KR+ E L E A K+Q L+ +L
Sbjct: 1073 KLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQ---LEEKL 1129
Query: 361 TLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMI 420
+ + + A ++++ + + ++LE++ +A K +
Sbjct: 1130 KKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAA 1189
Query: 421 EE-KALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRD---------AEISEKDDQS 470
E + L + E G+ E CR + E L +++ + A + K +
Sbjct: 1190 RELEELSERLEEAGGASAGQREG-CRKREAELGRLRRELEEAALRHEATVAALRRKQAEG 1248
Query: 471 QHNSDEEPESNVSVDQEIDAE------EVNSVQTAVKNLATA 506
E+ +S V Q+++ E EV+ + V+ L A
Sbjct: 1249 AAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRA 1290
Score = 50.4 bits (119), Expect = 5e-06
Identities = 121/587 (20%), Positives = 227/587 (38%), Gaps = 83/587 (14%)
Query: 57 EELNRQLEDIINTYGSAASTAGKEGSARASEQPENAESPDNEDGDCEETTEEAGREPVAS 116
EEL RQLE+ + K A A + + DC+ E+ E A
Sbjct: 1362 EELRRQLEE---------ESKAKSALAHAVQALRH---------DCDLLREQHEEEAEAQ 1403
Query: 117 GEPPTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEH 176
E + K ++ + K +Q +L+ ++K ++ E ++
Sbjct: 1404 AE-------LQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVE-- 1454
Query: 177 RTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRA 236
K L+K ++++Q E + + E RA A + L+ R L+R L+E R
Sbjct: 1455 -AANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLER---ALEE----RR 1506
Query: 237 REEEEKRKEITSHFQST------LTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYE 290
R+EEE ++E+ + + + L ++ E+ E L +EN L E++ + DQ
Sbjct: 1507 RQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVS 1566
Query: 291 LRE---EHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAK 347
L + L+K K E ++ + A LE+A+ ++ E + R + L AE + K
Sbjct: 1567 LSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAE--VDRK 1624
Query: 348 VLKEQETVLQAQLTLYSGRFEEFQSTL---TKSNEVFATFKQEMDKTTKKMKKLEKDTAT 404
+ ++ E + + E Q++L T++ K++M+ + +L+ AT
Sbjct: 1625 LAEKDEECANLRRN-HQRAVESLQASLDAETRARNEALRLKKKMEGDLNDL-ELQLGHAT 1682
Query: 405 WKARFENCNKALLD---------MIEEKALRAKEYECFVMKIGRLENLCRALQE-----E 450
+A L+ EE+ L A+ +E R L L+E E
Sbjct: 1683 RQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALE 1742
Query: 451 RNELHKKIRDAEISEKDDQ-----SQHNSDEEPESNVSVD--------QEIDAEEVNSVQ 497
+ E +++ + E+ E ++ SQ+ + + D +E E + +
Sbjct: 1743 QGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEE 1802
Query: 498 TAVKNLATAFMI---IHHPESTPHQSKETQPEIGSSQESADAALKEPEQPPLIPSRDSES 554
A K + A M+ + + T + + + + A L+E EQ L +
Sbjct: 1803 KAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQ 1862
Query: 555 PLPPLTPQAEAEGGSDAEPPSKASNSPAGLGAETQCEGLPVGAQADQ 601
L + EAE DAE A E + + L A+ D+
Sbjct: 1863 KLEAKVRELEAE--LDAEQKKHAEALKGVRKHERRVKELAYQAEEDR 1907
Score = 50.1 bits (118), Expect = 7e-06
Identities = 107/505 (21%), Positives = 199/505 (39%), Gaps = 98/505 (19%)
Query: 84 RASEQPENAESPDNEDGDCEETTEEAGREPVASGEPPTVKEPVSNK---EQKLEKKILKG 140
R +Q E+ E ++ TE A R+ G+ +E V++ +Q+LE+K+ K
Sbjct: 1075 RLEQQVEDLECSLEQEKKLRMDTERAKRK--LEGDLKLTQESVADAAQDKQQLEEKLKK- 1131
Query: 141 LGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKL--KLLQKKQVQIQKEKD 198
K++ L +L R E ++L +QKK ++Q +
Sbjct: 1132 --KDSELSQLSL------------------------RVEDEQLLGAQMQKKIKELQARAE 1165
Query: 199 QLQGEHSRAILARSKLE----SLCRELQRHNKTLKEEALQRAREEEEKRK---------- 244
+L+ E AR+++E REL+ ++ L+E A + E RK
Sbjct: 1166 ELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRR 1225
Query: 245 ---EITSHFQSTL-----------TDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYE 290
E ++T+ ++ Q++ KL +E +EL ++ + E
Sbjct: 1226 ELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVE 1285
Query: 291 -----------LREEHLDKI----FKHRELQQKLVDAKLEQAQEMMKEAE-ERHKREKEY 334
L + D++ K ELQ++L DA ++ + + E R EKE
Sbjct: 1286 TLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKEC 1345
Query: 335 LLNQAAEWK-LQAKVLKEQETVLQAQLTLYSGRFEEFQS------TLTKSNEVFATFKQE 387
L++Q + K L A+ L+E L+ + S Q+ L + +E A + E
Sbjct: 1346 LISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAE 1405
Query: 388 MDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEK----ALRAKEYECFV----MKIGR 439
+ + + K + A W++++E + +EE ALR +E E V K
Sbjct: 1406 LQRL---LSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSS 1462
Query: 440 LENLCRALQEERNELHKKI-RDAEISEKDDQSQHNSDEEPESNVSVDQEIDAEEVNSVQT 498
LE LQ E ++ ++ R + D+ Q + + E ++E+ E+ + Q
Sbjct: 1463 LEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQ-RELEAAQR 1521
Query: 499 AVKNLATAFMIIHHPESTPHQSKET 523
+ L T + H ++ ET
Sbjct: 1522 ESRGLGTELFRLRHGHEEALEALET 1546
Score = 47.4 bits (111), Expect = 4e-05
Identities = 69/318 (21%), Positives = 136/318 (42%), Gaps = 19/318 (5%)
Query: 206 RAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQ---IE 262
R+ A +L +L EL+ L +R +E EE IT +Q + +
Sbjct: 890 RSAQAEEELAALRAELRGLRGALAAAEAKR-QELEETHVSITQEKNDLALQLQAEQDNLA 948
Query: 263 QQSERNMKLCQENTELAEKLKSIIDQYELREE-HLDKIFKHR-------ELQQKLVDAKL 314
ER L + +L K+K + ++ E EE + D + R EL++ + D KL
Sbjct: 949 DAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKL 1008
Query: 315 EQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQA-QLTLYSGRFEEFQ-S 372
A+ KE + + K AA + A++ KE++ + +A Q L + EE + S
Sbjct: 1009 TLAKAE-KEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVS 1067
Query: 373 TLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEY-E 431
LTK+ ++++ + ++ KKL DT K + E K + + + A ++ E
Sbjct: 1068 ALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEE 1127
Query: 432 CFVMKIGRLENLCRALQEER---NELHKKIRDAEISEKDDQSQHNSDEEPESNVSVDQEI 488
K L L +++E+ ++ KKI++ + ++ + + ++ + V +
Sbjct: 1128 KLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAE 1187
Query: 489 DAEEVNSVQTAVKNLATA 506
A E+ + ++ A
Sbjct: 1188 AARELEELSERLEEAGGA 1205
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 69.7 bits (169), Expect = 8e-12
Identities = 104/517 (20%), Positives = 215/517 (41%), Gaps = 46/517 (8%)
Query: 3 ANHSEQLSAERQSTPPGDSSSLPSHNGLEKEDGQDSPTPVQ----PPEKEASVHPDISEE 58
A EQL+ T P ++ + +G + T PE E E
Sbjct: 61 AEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDEQKASHQHQEA 120
Query: 59 LNRQLEDIINTYGSAASTAGKEGSARASEQPENAESPDNEDGDCEETTEEAGREPVASGE 118
L R+LE ++T T K A ++A +G+ + +GE
Sbjct: 121 LRRELEAQVHTI--RILTCQKTELQMALYYSQHAVK--QLEGEARDLISRLHDSWKFAGE 176
Query: 119 PPTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRT 178
V+ +++K ++ I + L KE + L L + +E+ K E L +
Sbjct: 177 LEQALSAVATQKKKADRYI-EELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVES 235
Query: 179 EQKKLKLLQKK-------------QVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHN 225
E+ +++L K+ Q Q+Q E D L G+ +++ A KL++ E + N
Sbjct: 236 EKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHL-GKELQSVSA--KLQAQVEENELWN 292
Query: 226 KTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSI 285
+ L ++ ++ +EEK +E Q I+ Q E+ E+ K+ ++ + EK + +
Sbjct: 293 R-LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKM 351
Query: 286 IDQYELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAE----ERHKREKEYLL----- 336
Q E+ E +K+ + E+ + + K+ + +E M E E + KR++E +
Sbjct: 352 RRQEEMMWEKEEKMRRLEEMMWEK-EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 410
Query: 337 ---NQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTK 393
+A W+ + K+ +++E + + + ++ + + + E +QE ++ +
Sbjct: 411 RQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEK----RQEQEEMWR 466
Query: 394 KMKKLEKDTATWKARFENCNKALLDMIEEKALRAKE-YECFVMKIGRLENLCRALQEERN 452
+ +K+ + W+ + + + + EEK R +E KI E +E+
Sbjct: 467 QEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIR 526
Query: 453 ELHKKIRDAE--ISEKDDQSQHNSDEEPESNVSVDQE 487
E +KIR+ E I E+++ Q ++ E + ++
Sbjct: 527 EQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQ 563
Score = 66.6 bits (161), Expect = 7e-11
Identities = 71/359 (19%), Positives = 171/359 (47%), Gaps = 27/359 (7%)
Query: 123 KEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKK 182
+E + +E+K+ ++ K + ++ ++ + K++ EE +K L + +++K
Sbjct: 320 EEKIREQEEKIREQEEK-MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEK 378
Query: 183 LKLLQKKQVQIQKEKDQLQG-EHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEE 241
++ L++K + +K ++Q + + I + K + ++ R + ++E+ ++ RE+E+
Sbjct: 379 IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE-EKIREQEK 437
Query: 242 K--RKEITSHFQSTLTDIQGQIEQQSE-RNMKLCQENTELAEKLKSIIDQYELREEHLDK 298
K R+E H Q + + + + EQ+ R + +E E+ + + + +Q ++R++ +K
Sbjct: 438 KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQE-EK 496
Query: 299 IFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQA 358
+++ E K+ +E ++E EE+ R++E + Q + + Q + ++EQE ++Q
Sbjct: 497 VWRQEE--------KMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQE 548
Query: 359 QLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLD 418
Q + E+ Q + +QE +K K E++ W+ E + +
Sbjct: 549 QEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQ--EEKIREQEE 606
Query: 419 MIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEE 477
M++E+ + E E E +C +E+ E +K+R E + + + EE
Sbjct: 607 MMQEQEEKMWEQE---------EKMCEQ-EEKMQEQEEKMRRQEEKMWEQEVRLRQQEE 655
Score = 62.4 bits (150), Expect = 1e-09
Identities = 52/252 (20%), Positives = 128/252 (50%), Gaps = 19/252 (7%)
Query: 123 KEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKK 182
+E + +E+K+ ++ K +E + Q + + ++ + ++++ ++ ++ ++K
Sbjct: 422 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQK 481
Query: 183 LKLLQKKQVQIQKEKDQLQGE--HSRAILARSKLESLCRELQRHNKTLKEEALQRAREEE 240
K+ ++++++ Q+EK Q E H + R + E + R+ ++ ++E+ ++ RE+E
Sbjct: 482 EKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEK----IREQE-EKIREQE 536
Query: 241 EKRKEITSHFQSTLTDIQGQIEQQSERNM------KLCQENTELAEKLKSIIDQYELREE 294
EK +E Q + Q E+ E+ K+ ++ ++ E+ + I +Q E E
Sbjct: 537 EKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWE 596
Query: 295 HLDKIFKHRELQQKLVDAKLEQAQEM------MKEAEERHKREKEYLLNQAAEWKLQAKV 348
+KI + E+ Q+ + EQ ++M M+E EE+ +R++E + Q + Q +
Sbjct: 597 QEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 656
Query: 349 LKEQETVLQAQL 360
++E + L+A +
Sbjct: 657 MQEHQEHLEAAI 668
Score = 51.6 bits (122), Expect = 2e-06
Identities = 52/258 (20%), Positives = 116/258 (44%), Gaps = 14/258 (5%)
Query: 154 KLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSK 213
K Q E K +K E ++ R ++KK+ ++K + +K +++ + + + + +
Sbjct: 410 KRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEE 469
Query: 214 LESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQ 273
E+ R + + E+ R +EE+ R+E H Q I+ Q E+ + K+ +
Sbjct: 470 KIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEE--KIREQEEKMWRQEEKIRE 527
Query: 274 ENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLV------------DAKLEQAQEMM 321
+ ++ E+ + I +Q E+ +E +K+ + E Q+ + K+ + +E +
Sbjct: 528 QEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKI 587
Query: 322 KEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVF 381
+E EE+ ++E + Q + Q + + EQE + Q + E+ + K E
Sbjct: 588 REQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 647
Query: 382 ATFKQEMDKTTKKMKKLE 399
+Q+ +K + + LE
Sbjct: 648 VRLRQQEEKMQEHQEHLE 665
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 69.7 bits (169), Expect = 8e-12
Identities = 94/395 (23%), Positives = 176/395 (44%), Gaps = 67/395 (16%)
Query: 118 EPPTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKF-DFLFKK--YAELLD 174
+P + + + K+++ +++L+ L + + +L+ + K D++ K + LL+
Sbjct: 146 KPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLE 205
Query: 175 EHRTEQKKLKLLQKKQVQIQKEKD---QLQGEHSRAILARSKLESLCRELQRHNKTLK-- 229
+ R KKL L Q+K Q +KEK+ +L + +S L E Q H + L
Sbjct: 206 QERERLKKL-LEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQ 264
Query: 230 ----EEALQRAREEEEKRKEITSHFQST---LTDIQGQIEQQSERNMKLCQENTELAEKL 282
++ Q+ REEEEK K ITS + L ++ E ++ R QE+ E+ KL
Sbjct: 265 SQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASR---FSQEHEEMNAKL 321
Query: 283 KSIIDQYELREEHLDKIFKHRELQQKLVDA-----KLEQAQEMMKEAEERHKREKEYLLN 337
+ +E H +R+L+ KLV +LE+ + +++AEE + ++ +
Sbjct: 322 AN-------QESH------NRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAK 368
Query: 338 -QAAEWKLQAKVLKEQETVLQAQ-----LTLYSGRFEEFQSTLTKSNEVFATFKQEMDKT 391
+ L A+V ++ VL+ + +T + E + L + + E++K
Sbjct: 369 GECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKL 428
Query: 392 TKKMKKLEK-DTATWKARFE------------NCNKALLDMIEEKALRAKEYECFVMK-- 436
K+M +LEK + A K++ E N K LL+ +E R KE EC +
Sbjct: 429 QKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLE 488
Query: 437 ---------IGRLENLCRALQEERNELHKKIRDAE 462
+ +L++ L +ER + +KI+ E
Sbjct: 489 KAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEE 523
Score = 48.5 bits (114), Expect = 2e-05
Identities = 99/478 (20%), Positives = 178/478 (37%), Gaps = 70/478 (14%)
Query: 71 GSAASTAGKEGSARASEQPENAESPDNEDGDCEETTEEAGREPVASGEPPTVKEPVSNKE 130
G +++ G + S E +ED ++ + + +ASG TVK +
Sbjct: 7 GGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASG---TVKRHLKTSG 63
Query: 131 QKLEKKILKGLGKEANLLMQNLN----KLQTPEEKFDFLF--KKYAELLDEH---RTEQK 181
+ E+K K L L+Q L+ +LQ E+ L K E+L+ H +K
Sbjct: 64 E-CERKTKKSLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEK 122
Query: 182 KLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRH---NKTLKEEALQRARE 238
L++L + + Q EK + + + I +LE +E R L E+ +R
Sbjct: 123 VLRVLHRDAILAQ-EKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVY 181
Query: 239 EEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDK 298
E E K + + + D +EQ+ ER LK +++Q
Sbjct: 182 ELENEKHKHTDYMNKSDDFTNLLEQERER--------------LKKLLEQ---------- 217
Query: 299 IFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQA 358
E+A + KE E + K L ++ + K A +L ++ +
Sbjct: 218 ----------------EKAYQARKEKENAKRLNK--LRDELVKLKSFALMLVDERQMHIE 259
Query: 359 QLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARF----ENCNK 414
QL L S + ++ L + E + + +K+ KLE D +RF E N
Sbjct: 260 QLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNA 319
Query: 415 ALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNS 474
L + + +I LE + LQ+ EL +++RD + S +
Sbjct: 320 KLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEEL-QELRDKIAKGECGNSSLMA 378
Query: 475 DEEPESNVSVDQEIDAEEVNSVQTAVKNLATAFMIIHHPESTPHQSKETQPEIGSSQE 532
+ E ++ E EE+ ++ + L + H SKE + E+ Q+
Sbjct: 379 EVENLRKRVLEMEGKDEEITKTESQCRELRKKL------QEEEHHSKELRLEVEKLQK 430
Score = 45.4 bits (106), Expect = 2e-04
Identities = 58/279 (20%), Positives = 120/279 (43%), Gaps = 40/279 (14%)
Query: 152 LNKLQTPEEKFDFLFKKYA-----------ELLDEHRTEQKKLKLLQKKQVQIQKEKDQL 200
+ K++ E K D L K + +L++E + K +++K + +E+D+L
Sbjct: 516 MEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDEL 575
Query: 201 QG----EHSRAILARSKLESLCRELQRHNKTLKEEALQRARE-------EEEKRKEITSH 249
G E ++ ++ L + L + +E R+R+ E+ K KE+T
Sbjct: 576 IGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLE 635
Query: 250 FQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKL 309
+ +Q Q+E MK E +L +K ++ D+ + L++I KH+ + K
Sbjct: 636 IERLKKRLQ-QLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEI-KHQIAKNKA 693
Query: 310 VDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKE----------QETVLQAQ 359
+ E+ + + +EAE RH+ E ++ + K + + LKE Q + LQ
Sbjct: 694 I----EKGEVVSQEAELRHRFRLEEA--KSRDLKAEVQALKEKIHELMNKEDQLSQLQVD 747
Query: 360 LTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKL 398
++ RF E ++ + +E++ + + + L
Sbjct: 748 YSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRAL 786
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 69.3 bits (168), Expect = 1e-11
Identities = 89/424 (20%), Positives = 184/424 (43%), Gaps = 59/424 (13%)
Query: 86 SEQPENAESPDNEDGDCE---------ETTEEAGREPVASGEPPTVKEPVSNKEQKLEKK 136
SE+ E E D + D E E E E E ++EQ ++
Sbjct: 155 SEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE 214
Query: 137 IL--KGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQ 194
+L + G+E K Q E+ D +F++ +E + +K+ +L+K++ ++Q
Sbjct: 215 LLELRRKGRE--------EKQQQRRERQDRVFQE-----EEEKEWRKRETVLRKEEEKLQ 261
Query: 195 KEKDQLQGE-----HSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSH 249
+E+ Q Q E L R +L +E ++ + L+ E R ++EEE+R++
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQ---- 317
Query: 250 FQSTLTDIQGQIEQQSE-RNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQK 308
Q + Q + EQQ E R +L +E E E+ + E RE+ L RE +++
Sbjct: 318 -QEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQL-----RREQEEE 371
Query: 309 LVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFE 368
+ +L + Q++ +E + R +E L + + + + ++ +EQ+ + QL
Sbjct: 372 RREQQLRREQQLRREQQLR----REQQLRREQQLRREQQLRREQQLRREQQL-------R 420
Query: 369 EFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAK 428
Q + E K E ++ +++K+ +++ W R E + + +++ R +
Sbjct: 421 REQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQ 480
Query: 429 EYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEEPESNVSVDQEI 488
E E R E + +EER E ++ R+ ++ + ++ + + E + Q +
Sbjct: 481 EEE-------RRERWLKLEEEERREQQER-REQQLRREQEERREQRLKRQEEEERLQQRL 532
Query: 489 DAEE 492
+E+
Sbjct: 533 RSEQ 536
Score = 63.5 bits (153), Expect = 6e-10
Identities = 97/413 (23%), Positives = 178/413 (43%), Gaps = 43/413 (10%)
Query: 123 KEPVSNKEQKLEKKILKG---LGKEANLLMQNLNKLQTPE-----EKFDFLFKKYAELLD 174
+EP + Q+ EKK + +E LL + K + E K D L ++ +LL
Sbjct: 976 EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLR 1035
Query: 175 EHRTEQKKLKLLQKK---QVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEE 231
E R E+++L+ +++ + ++Q+E++QL GE R R +LE R+ + L++E
Sbjct: 1036 EER-EKRRLQERERQYREEEELQQEEEQLLGEE-RETRRRQELERQYRK----EEELQQE 1089
Query: 232 ALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQ--SERNMKLCQENTELAEKLKSIIDQY 289
Q REE EKR+ Q + Q E+Q E K ++ E + + + Q
Sbjct: 1090 EEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQE 1149
Query: 290 E---LREE-------HLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQA 339
E LREE L++ ++ E Q+ + L + QE ++ ER RE+E L Q
Sbjct: 1150 EEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQK 1209
Query: 340 AEWKL----QAKVLK-----EQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDK 390
+ + Q LK E+E ++ GR E L S +Q++
Sbjct: 1210 RKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQH 1269
Query: 391 TTKKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEE 450
+ + E+D + R++ ++ EE+ L +E + + + + + L+EE
Sbjct: 1270 LLGEQQ--ERDREQERRRWQQRDR---HFPEEEQLEREEQKEAKRRDRKSQEEKQLLREE 1324
Query: 451 RNELHKKIRDAEISEKDDQSQHNSDEEPESNVSVDQEIDAEEVNSVQTAVKNL 503
R E ++ +++Q +E+P D++ EE+ + K L
Sbjct: 1325 REEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFL 1377
Score = 61.2 bits (147), Expect = 3e-09
Identities = 100/520 (19%), Positives = 220/520 (42%), Gaps = 33/520 (6%)
Query: 2 EANHSEQLSAERQSTPPGDSSSLPSHNG-LEKE-DGQDSPTPVQPPEKEASVHPDISEEL 59
E E E++ S +P LE E D + S +P ++E EE
Sbjct: 679 ERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEK 738
Query: 60 NRQLEDIINTYGSAASTAGKEGSARASEQPENAESPDNEDGDCEETTEEAGREPVASGEP 119
R+ E + +E A +Q E EE +E GR+ +++ P
Sbjct: 739 RRRRESELQWQ--------EEERAHRQQQEEEQRRDFTWQWQAEEKSER-GRQRLSARPP 789
Query: 120 ---PTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNK---LQTPEEKFDFLFKKYAELL 173
++ + + Q+ E++ L ++ Q + LQ EE+ ++ A+ L
Sbjct: 790 LREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQL 849
Query: 174 DEHRT--EQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEE 231
E ++ + + ++Q + QK + QL+ E R +L +L++ + L+EE
Sbjct: 850 QEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEE 909
Query: 232 ALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYEL 291
+ REE EKR+ Q + Q++Q+ E+ ++ +E E+ + +L
Sbjct: 910 EEELQREEREKRRRQEQERQYREEE---QLQQEEEQLLREEREKRRRQERERQYRKDKKL 966
Query: 292 REEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEE---RHKREKEYLLNQAAEWKLQAKV 348
+++ + + E +++ K + +E +++ EE R +REK +++ + ++
Sbjct: 967 QQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDEL 1026
Query: 349 LKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEM--DKTTKKMKKLEKDTATWK 406
+E+E +L+ + R +E + + E+ +Q + ++ T++ ++LE+ +
Sbjct: 1027 QQEEEQLLREERE--KRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEE 1084
Query: 407 ARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEK 466
+ + L + E++ + +E +C + + E + L+EER + ++ + + E+
Sbjct: 1085 ELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEE-QLLREEREKRRRQELERQYREE 1143
Query: 467 DDQSQHNSD---EEPESNVSVDQEIDAEEVNSVQTAVKNL 503
++ Q EEPE + E E +Q + L
Sbjct: 1144 EEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQL 1183
Score = 60.8 bits (146), Expect = 4e-09
Identities = 87/433 (20%), Positives = 183/433 (42%), Gaps = 44/433 (10%)
Query: 79 KEGSARASEQPENAESPDNEDGDCEETTEEAGREPVASGEPPTVKEPVSNK-EQKLEKKI 137
K+ R +Q E E + + E ++ RE E +E + EQ+L ++
Sbjct: 309 KQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRRE- 367
Query: 138 LKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEK 197
+E Q L + Q + ++ + R EQ+ + Q ++ Q + +
Sbjct: 368 -----QEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 422
Query: 198 DQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEE---KRKEITSHFQSTL 254
QL+ E R Q+H + +E+ L+R +EE KR+E T +
Sbjct: 423 QQLRREQEEE-----------RHEQKHEQERREQRLKREQEERRDWLKREEETERHEQER 471
Query: 255 TDIQGQIEQQSERNMKLC----QENTELAEKLKSII--DQYELREEHLDKIFKHRELQQK 308
Q + +Q+ ER + +E E E+ + + +Q E RE+ L + + LQQ+
Sbjct: 472 RKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQR 531
Query: 309 L-VDAKLEQAQE------MMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLT 361
L + +L + QE + +E E+R ++E+ + + + + ++LK +E Q +L
Sbjct: 532 LRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRL- 590
Query: 362 LYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIE 421
EE K EV + +++ ++ ++L+++ + R + +
Sbjct: 591 --KREQEERLEQRLKREEV-----ERLEQEERREQRLKREEPEEERRQQLLKSEEQEERR 643
Query: 422 EKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQS--QHNSDEEPE 479
++ LR ++ E ++ R E R Q + E ++ R+ E++E++ + + P+
Sbjct: 644 QQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPK 703
Query: 480 SNVSVDQEIDAEE 492
++ E DA +
Sbjct: 704 WQWQLESEADARQ 716
Score = 55.8 bits (133), Expect = 1e-07
Identities = 45/211 (21%), Positives = 109/211 (51%), Gaps = 11/211 (5%)
Query: 143 KEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQG 202
+E L+Q + Q ++ D +K+ E + R ++++ K LQ++Q Q+++++ + +
Sbjct: 1670 REEEQLLQEGEEQQLRRQERD---RKFREEEQQLRRQERERKFLQEEQ-QLRRQELERKF 1725
Query: 203 EHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIE 262
+ ++ E L R+ +R+ K L+EE L+ REE++ R++ ++ + E
Sbjct: 1726 REEEQLRQETEQEQLRRQ-ERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQERE 1784
Query: 263 QQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQAQEMMK 322
+Q R+ + ++ E E+L+ ++ +LR + D ++ E Q +LE+ ++ ++
Sbjct: 1785 EQQLRSQESDRKFRE-EEQLRQEREEQQLRPQQRDGKYRWEEEQ-----LQLEEQEQRLR 1838
Query: 323 EAEERHKREKEYLLNQAAEWKLQAKVLKEQE 353
+ +R R +E Q + + ++ +E+E
Sbjct: 1839 QERDRQYRAEEQFATQEKSRREEQELWQEEE 1869
Score = 54.7 bits (130), Expect = 3e-07
Identities = 98/526 (18%), Positives = 210/526 (39%), Gaps = 53/526 (10%)
Query: 2 EANHSEQLSAERQSTPPGDSSSLPSHNGLEKEDGQDSPTPVQPPEK---EASVHPDISEE 58
+ EQ A+R+ + L EK Q++ + E+ E P +E
Sbjct: 1298 QLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQE 1357
Query: 59 LNRQLEDIINTYGSAASTAGKEGSARASEQPENAESPDNEDGDCEETTEEA--GREPVAS 116
+R+ + + +E ++ E + + C+E ++ R+
Sbjct: 1358 RDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFR 1417
Query: 117 GEPPTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDE- 175
E + +++ + E++ ++ +E L + Q KF ++ +LL E
Sbjct: 1418 EEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKF----REEEQLLQER 1473
Query: 176 -----HRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKL---ESLCRELQRHNKT 227
HR E+ + L +++Q++ Q+ + + + R+ K E QR K
Sbjct: 1474 EEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKF 1533
Query: 228 LKEEALQRA---------------REEEEKRKEITSHFQSTL-TDIQGQIEQQSERNMKL 271
L+EE R REEE+ R+E S D + ++E+Q R +
Sbjct: 1534 LQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQ 1593
Query: 272 CQENTELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKL---EQAQEMMKEAEERH 328
++ E ++L+ Q +LR+E K + +L Q+ + +L E+ ++ ++E +
Sbjct: 1594 ERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLR 1653
Query: 329 KREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEM 388
++E+E L + K +E+E +LQ EE Q + + F +Q++
Sbjct: 1654 RQEREQQLRHDRDRK-----FREEEQLLQ--------EGEEQQLRRQERDRKFREEEQQL 1700
Query: 389 DKTTKKMKKLEKDTATWKARFENC---NKALLDMIEEKALRAKEYECFVMKIGRLENLCR 445
+ ++ K L+++ + E + L E++ LR +E +++ +L
Sbjct: 1701 RRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPERE 1760
Query: 446 ALQEERNELHKKIRDAEISEKDDQSQHNSDEEPESNVSVDQEIDAE 491
Q R E +K R+ E ++ + Q +E + ++++ E
Sbjct: 1761 EQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQE 1806
Score = 51.2 bits (121), Expect = 3e-06
Identities = 65/317 (20%), Positives = 143/317 (45%), Gaps = 23/317 (7%)
Query: 174 DEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEAL 233
D H E+++L+ ++K+ + + K Q + + L R + E R + K +EE L
Sbjct: 1290 DRHFPEEEQLEREEQKEAKRRDRKSQEEKQ-----LLREEREEKRRRQETDRKFREEEQL 1344
Query: 234 QRAREEEE-KRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELR 292
+ REE+ +R+E F+ Q Q + E +L ++ E + + + R
Sbjct: 1345 LQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQER 1404
Query: 293 EEHL--DKIFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLK 350
E+ L D+ K RE +Q+L + ++ ++ R +RE+++L + + + + +
Sbjct: 1405 EQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFR 1464
Query: 351 EQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFE 410
E+E +LQ + EE Q + + F +Q++ + + K E++ R +
Sbjct: 1465 EEEQLLQER--------EEQQLHRQERDRKFLEEEQQLRRQERDRKFREQE-----LRSQ 1511
Query: 411 NCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEKDDQS 470
+ L+ E++ R + F+ + +L R Q+ R + +K R+ E ++ +
Sbjct: 1512 EPERKFLEE-EQQLHRQQRQRKFLQEEQQLRRQERG-QQRRQDRDRKFREEEQLRQEREE 1569
Query: 471 QHNSDEEPESNVSVDQE 487
Q S +E + ++++
Sbjct: 1570 QQLSRQERDRKFRLEEQ 1586
Score = 50.8 bits (120), Expect = 4e-06
Identities = 63/327 (19%), Positives = 140/327 (42%), Gaps = 51/327 (15%)
Query: 171 ELLDEHRTEQKKLKLLQKKQVQIQKE----KDQLQGEHSRAILARSKLESLCRELQRHNK 226
E L + R +++ + + + Q+++E + Q + E R + + L++ ++
Sbjct: 107 ESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDR 166
Query: 227 TLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSII 286
++E L R R+E ++R+E + E ++ C+ + +
Sbjct: 167 QRRDEELWRQRQEWQEREE----------------RRAEEEQLQSCK-----GHETEEFP 205
Query: 287 DQYELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQA 346
D+ +LR L EL++K E+ Q+ +E ++R +E+E EW+ +
Sbjct: 206 DEEQLRRREL------LELRRK----GREEKQQQRRERQDRVFQEEE-----EKEWRKRE 250
Query: 347 KVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWK 406
VL+++E LQ + +E + L K ++E + ++ ++L ++ +
Sbjct: 251 TVLRKEEEKLQEEEPQRQRELQEEEEQLRKLER--QELRRERQEEEQQQQRLRREQQLRR 308
Query: 407 ARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEERNELHKKIRDAEISEK 466
+ E + + E++ R ++ E R E R QEER E + R+ E +
Sbjct: 309 KQEEERREQQEERREQQERREQQEE-------RREQQLRREQEERREQQLR-REQEEERR 360
Query: 467 DDQSQHNSDEE-PESNVSVDQEIDAEE 492
+ Q + +EE E + +Q++ E+
Sbjct: 361 EQQLRREQEEERREQQLRREQQLRREQ 387
Score = 47.4 bits (111), Expect = 4e-05
Identities = 73/389 (18%), Positives = 162/389 (41%), Gaps = 22/389 (5%)
Query: 103 EETTEEAGREPVASGEPPTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKF 162
E+ E+ RE E ++ + +E++ ++ LK +E L Q L + + E+
Sbjct: 555 EKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER--LEQRLKREEV--ERL 610
Query: 163 DFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQ 222
+ ++ L E E+++ +LL K + Q ++ + QL+ E R K E L+
Sbjct: 611 EQEERREQRLKREEPEEERRQQLL-KSEEQEERRQQQLRREQQERREQRLKREEEEERLE 669
Query: 223 RHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKL 282
+ K EE + EE++++ +S + Q Q+E +++ E
Sbjct: 670 QRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQ 729
Query: 283 KSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQAQEM--MKEAEERHKREKEYLLNQAA 340
+ +Q E R ++ E + + EQ ++ +AEE+ +R ++ L +
Sbjct: 730 RRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPP 789
Query: 341 EWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKK--- 397
+ + + L+ +E + Q L +E + + E F +E ++ ++ +
Sbjct: 790 LREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQL 849
Query: 398 ------LEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCR---ALQ 448
L++D +++ + ++ +EE+ R + K E L + LQ
Sbjct: 850 QEEEDGLQEDQERRRSQEQRRDQKWRWQLEEE--RKRRRHTLYAKPALQEQLRKEQQLLQ 907
Query: 449 EERNELHKKIRDAEISEKDDQSQHNSDEE 477
EE EL ++ R+ ++ + Q+ +E+
Sbjct: 908 EEEEELQREEREKR-RRQEQERQYREEEQ 935
Score = 44.7 bits (104), Expect = 3e-04
Identities = 46/183 (25%), Positives = 89/183 (48%), Gaps = 16/183 (8%)
Query: 167 KKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQG-EHSRAILARSKL-----ESLCRE 220
+K+ + + R ++ + K +++Q++ + E++QL+ E R IL +L E R
Sbjct: 1707 RKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRR 1766
Query: 221 LQRHNKTLKEEALQRAREEEEKR-KEITSHFQSTLTDIQGQIEQQ---SERNMKLCQENT 276
+R K +EE L++ REE++ R +E F+ Q + EQQ +R+ K E
Sbjct: 1767 QERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEE 1826
Query: 277 ELA-----EKLKSIID-QYELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERHKR 330
+L ++L+ D QY E+ + RE Q+ + + ++ QE ++ E H R
Sbjct: 1827 QLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIR 1886
Query: 331 EKE 333
++
Sbjct: 1887 RQQ 1889
Score = 40.8 bits (94), Expect = 0.004
Identities = 48/236 (20%), Positives = 96/236 (40%), Gaps = 22/236 (9%)
Query: 259 GQIEQQSERNMKLCQENTELAEKLKSIIDQ--YELREEHLD------KIFKHRELQQKLV 310
GQ E C L + + DQ +E R+ L+ + K +E +++L
Sbjct: 90 GQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELA 149
Query: 311 DAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEF 370
+ + + ++ E +R +R++E L Q EW+ + + E+E + + EEF
Sbjct: 150 EGEEQSEKQERLEQRDRQRRDEE-LWRQRQEWQEREERRAEEEQLQSCK----GHETEEF 204
Query: 371 -------QSTLTKSNEVFATFKQEMDKTTKKMKKLEKDTATWKARFENCNKALLDMIEEK 423
+ L + KQ+ + + E++ W+ R K + EE+
Sbjct: 205 PDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEE 264
Query: 424 ALRAKEYECFVMKIGRLE--NLCRALQEERNELHKKIRDAEISEKDDQSQHNSDEE 477
R +E + ++ +LE L R QEE + + R+ ++ K ++ + EE
Sbjct: 265 PQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEE 320
Score = 36.2 bits (82), Expect = 0.10
Identities = 25/123 (20%), Positives = 59/123 (47%), Gaps = 6/123 (4%)
Query: 129 KEQKLEKKILKGLGKEANLLMQNLNKLQTPEEKFDFLFKKYAELLDEHRTEQKKLKLL-- 186
+EQ+L ++ +E L Q + Q ++ D F++ +L E +Q + +
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDG 1819
Query: 187 ----QKKQVQIQKEKDQLQGEHSRAILARSKLESLCRELQRHNKTLKEEALQRAREEEEK 242
+++Q+Q+++++ +L+ E R A + + + + + +EE +R +E E K
Sbjct: 1820 KYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERK 1879
Query: 243 RKE 245
+E
Sbjct: 1880 LRE 1882
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.122 0.331
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,238,051
Number of Sequences: 37866
Number of extensions: 1517563
Number of successful extensions: 17198
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 379
Number of HSP's successfully gapped in prelim test: 1771
Number of HSP's that attempted gapping in prelim test: 9196
Number of HSP's gapped (non-prelim): 6202
length of query: 684
length of database: 18,247,518
effective HSP length: 109
effective length of query: 575
effective length of database: 14,120,124
effective search space: 8119071300
effective search space used: 8119071300
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.