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Search of human proteins with 222418622
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]
(347 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens] 724 0.0
gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens] 654 0.0
gi|19424132 NIMA-related kinase 7 [Homo sapiens] 488 e-138
gi|41872673 NIMA-related kinase 1 [Homo sapiens] 185 6e-47
gi|148839316 NIMA-related kinase 4 [Homo sapiens] 182 5e-46
gi|83627721 NIMA-related kinase 5 [Homo sapiens] 182 5e-46
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 176 3e-44
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens] 175 6e-44
gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens] 175 6e-44
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens] 175 6e-44
gi|4505373 NIMA-related kinase 2 [Homo sapiens] 173 2e-43
gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens] 167 1e-41
gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens] 167 1e-41
gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens] 167 1e-41
gi|222136641 NIMA-related kinase 9 [Homo sapiens] 167 2e-41
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 147 1e-35
gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo sa... 144 9e-35
gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo sa... 144 9e-35
gi|4759208 TAO kinase 2 isoform 1 [Homo sapiens] 136 3e-32
gi|45505130 TAO kinase 2 isoform 2 [Homo sapiens] 136 3e-32
gi|148746218 TAO kinase 3 [Homo sapiens] 133 3e-31
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 131 1e-30
gi|45439370 TAO kinase 1 [Homo sapiens] 131 1e-30
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 131 1e-30
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 130 2e-30
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens] 129 4e-30
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 129 4e-30
gi|55956904 mitogen-activated protein kinase kinase kinase 4 iso... 129 5e-30
gi|55956902 mitogen-activated protein kinase kinase kinase 4 iso... 129 5e-30
gi|4826878 oxidative-stress responsive 1 [Homo sapiens] 128 7e-30
>gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]
Length = 347
Score = 724 bits (1870), Expect = 0.0
Identities = 347/347 (100%), Positives = 347/347 (100%)
Query: 1 MPRREVCWEAAHFRQEEQSLPRPRVRALVRLACRMAGQPGHMPHGGSSNNLCHTLGPVHP 60
MPRREVCWEAAHFRQEEQSLPRPRVRALVRLACRMAGQPGHMPHGGSSNNLCHTLGPVHP
Sbjct: 1 MPRREVCWEAAHFRQEEQSLPRPRVRALVRLACRMAGQPGHMPHGGSSNNLCHTLGPVHP 60
Query: 61 PDPQRHPNTLSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKA 120
PDPQRHPNTLSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKA
Sbjct: 61 PDPQRHPNTLSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKA 120
Query: 121 RQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPE 180
RQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPE
Sbjct: 121 RQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPE 180
Query: 181 RTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHS 240
RTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHS
Sbjct: 181 RTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHS 240
Query: 241 LVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDY 300
LVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDY
Sbjct: 241 LVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDY 300
Query: 301 PPLPGEHYSEKLRELVSMCICPDPHQRPDIGYVHQVAKQMHIWMSST 347
PPLPGEHYSEKLRELVSMCICPDPHQRPDIGYVHQVAKQMHIWMSST
Sbjct: 301 PPLPGEHYSEKLRELVSMCICPDPHQRPDIGYVHQVAKQMHIWMSST 347
>gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]
Length = 313
Score = 654 bits (1687), Expect = 0.0
Identities = 313/313 (100%), Positives = 313/313 (100%)
Query: 35 MAGQPGHMPHGGSSNNLCHTLGPVHPPDPQRHPNTLSFRCSLADFQIEKKIGRGQFSEVY 94
MAGQPGHMPHGGSSNNLCHTLGPVHPPDPQRHPNTLSFRCSLADFQIEKKIGRGQFSEVY
Sbjct: 1 MAGQPGHMPHGGSSNNLCHTLGPVHPPDPQRHPNTLSFRCSLADFQIEKKIGRGQFSEVY 60
Query: 95 KATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNI 154
KATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNI
Sbjct: 61 KATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNI 120
Query: 155 VLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFI 214
VLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFI
Sbjct: 121 VLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFI 180
Query: 215 TATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEM 274
TATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEM
Sbjct: 181 TATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEM 240
Query: 275 AALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICPDPHQRPDIGYVH 334
AALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICPDPHQRPDIGYVH
Sbjct: 241 AALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICPDPHQRPDIGYVH 300
Query: 335 QVAKQMHIWMSST 347
QVAKQMHIWMSST
Sbjct: 301 QVAKQMHIWMSST 313
>gi|19424132 NIMA-related kinase 7 [Homo sapiens]
Length = 302
Score = 488 bits (1256), Expect = e-138
Identities = 238/293 (81%), Positives = 264/293 (90%), Gaps = 6/293 (2%)
Query: 60 PPDPQRHPNT-----LSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFE 114
PP PQ P + + +LA+F+IEKKIGRGQFSEVY+A CLLD VALKKVQIF+
Sbjct: 11 PPVPQFQPQKALRPDMGYN-TLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFD 69
Query: 115 MMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQ 174
+MDAKAR DC+KEI LLKQLNHPN+IKY SFIEDNELNIVLELADAGDLS+MIK+FKKQ
Sbjct: 70 LMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQ 129
Query: 175 KRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSE 234
KRLIPERTVWKYFVQLCSA+EHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSS+
Sbjct: 130 KRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSK 189
Query: 235 TTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQK 294
TTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNL+SLC+K
Sbjct: 190 TTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKK 249
Query: 295 IEQCDYPPLPGEHYSEKLRELVSMCICPDPHQRPDIGYVHQVAKQMHIWMSST 347
IEQCDYPPLP +HYSE+LR+LV+MCI PDP +RPD+ YV+ VAK+MH +S+
Sbjct: 250 IEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYVYDVAKRMHACTASS 302
>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
Length = 1258
Score = 185 bits (469), Expect = 6e-47
Identities = 99/266 (37%), Positives = 153/266 (57%), Gaps = 9/266 (3%)
Query: 83 KKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKY 142
+KIG G F + D + +K++ I M +K R++ +E+ +L + HPNI++Y
Sbjct: 8 QKIGEGSFGKAILVKSTEDGRQYVIKEINI-SRMSSKEREESRREVAVLANMKHPNIVQY 66
Query: 143 LDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRV 202
+SF E+ L IV++ + GDL + I K L E + +FVQ+C A++H+H R++
Sbjct: 67 RESFEENGSLYIVMDYCEGGDLFKRINAQKGV--LFQEDQILDWFVQICLALKHVHDRKI 124
Query: 203 MHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKS 262
+HRDIK N+F+T G V+LGD G+ R +S A + +GTPYY+SPE YN KS
Sbjct: 125 LHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKS 184
Query: 263 DIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICP 322
DIW+LGC+LYE+ L+ F M +L KI +PP+ HYS LR LVS
Sbjct: 185 DIWALGCVLYELCTLKHAFEAGSMK--NLVLKIISGSFPPV-SLHYSYDLRSLVSQLFKR 241
Query: 323 DPHQRPDIGYVHQ---VAKQMHIWMS 345
+P RP + + + +AK++ ++S
Sbjct: 242 NPRDRPSVNSILEKGFIAKRIEKFLS 267
>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
Length = 841
Score = 182 bits (461), Expect = 5e-46
Identities = 100/276 (36%), Positives = 161/276 (58%), Gaps = 10/276 (3%)
Query: 76 LADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLN 135
LA + + +G+G + EV D K +KK+ + ++ R+ +E LL QL
Sbjct: 3 LAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNL-RNASSRERRAAEQEAQLLSQLK 61
Query: 136 HPNIIKYLDSFIE-DNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAV 194
HPNI+ Y +S+ D L IV+ + GDL + +K K Q L+PE V ++FVQ+ A+
Sbjct: 62 HPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQ--LLPENQVVEWFVQIAMAL 119
Query: 195 EHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIH 254
+++H + ++HRD+K NVF+T T ++K+GDLG+ R + A +L+GTPYYMSPE
Sbjct: 120 QYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFS 179
Query: 255 ENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRE 314
YN+KSD+W+LGC +YEMA L+ F MN SL +I + PP+P + YS +L E
Sbjct: 180 NKPYNYKSDVWALGCCVYEMATLKHAFNAKDMN--SLVYRIIEGKLPPMPRD-YSPELAE 236
Query: 315 LVSMCICPDPHQRPDIGYVHQ---VAKQMHIWMSST 347
L+ + P +RP + + + + +Q+ ++ +T
Sbjct: 237 LIRTMLSKRPEERPSVRSILRQPYIKRQISFFLEAT 272
>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
Length = 708
Score = 182 bits (461), Expect = 5e-46
Identities = 99/257 (38%), Positives = 152/257 (59%), Gaps = 9/257 (3%)
Query: 79 FQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPN 138
+ + K IG+G F + Y A D K +K++ FE M + ++ KE+ LL+++ HPN
Sbjct: 4 YDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEIN-FEKMPIQEKEASKKEVILLEKMKHPN 62
Query: 139 IIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMH 198
I+ + +SF E+ L IV+E D GDL + I +++ L E + +FVQ+ ++H+H
Sbjct: 63 IVAFFNSFQENGRLFIVMEYCDGGDLMKRIN--RQRGVLFSEDQILGWFVQISLGLKHIH 120
Query: 199 SRRVMHRDIKPANVFITATGVV-KLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENG 257
R+++HRDIK N+F++ G+V KLGD G+ R ++ A + +GTPYY+SPE
Sbjct: 121 DRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKP 180
Query: 258 YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPL-PGEHYSEKLRELV 316
YN K+DIWSLGC+LYE+ L+ PF G+ NL L KI Q + P+ PG +S +L L+
Sbjct: 181 YNNKTDIWSLGCVLYELCTLKHPFEGN--NLQQLVLKICQAHFAPISPG--FSRELHSLI 236
Query: 317 SMCICPDPHQRPDIGYV 333
S P RP I +
Sbjct: 237 SQLFQVSPRDRPSINSI 253
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 176 bits (446), Expect = 3e-44
Identities = 97/250 (38%), Positives = 154/250 (61%), Gaps = 8/250 (3%)
Query: 85 IGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLD 144
+GRG F V+ D+K V +K++ + E M + RQ E +LK LNHPN+I+Y +
Sbjct: 10 VGRGAFGIVHLCLRKADQKLVIIKQIPV-EQMTKEERQAAQNECQVLKLLNHPNVIEYYE 68
Query: 145 SFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMH 204
+F+ED L I +E A G L++ I+ K+ L+ E T+ +FVQ+ A+ H+H+ ++H
Sbjct: 69 NFLEDKALMIAMEYAPGGTLAEFIQ--KRCNSLLEEETILHFFVQILLALHHVHTHLILH 126
Query: 205 RDIKPANVFITATG-VVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSD 263
RD+K N+ + VVK+GD G+ + SS++ A +++VGTP Y+SPE YN KSD
Sbjct: 127 RDLKTQNILLDKHRMVVKIGDFGISKILSSKSKA-YTVVGTPCYISPELCEGKPYNQKSD 185
Query: 264 IWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICPD 323
IW+LGC+LYE+A+L+ F + NL +L KI + P+ + YS +LR+LV + +
Sbjct: 186 IWALGCVLYELASLKRAF--EAANLPALVLKIMSGTFAPI-SDRYSPELRQLVLSLLSLE 242
Query: 324 PHQRPDIGYV 333
P QRP + ++
Sbjct: 243 PAQRPPLSHI 252
>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
Length = 489
Score = 175 bits (443), Expect = 6e-44
Identities = 98/251 (39%), Positives = 140/251 (55%), Gaps = 7/251 (2%)
Query: 78 DFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHP 137
D+ + + IG G F + A+K++++ + Q+ KE LL ++ HP
Sbjct: 3 DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNT--QNSRKEAVLLAKMKHP 60
Query: 138 NIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHM 197
NI+ + +SF + L IV+E D GDL Q IK +++ +L PE + +F Q+C V H+
Sbjct: 61 NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIK--QQKGKLFPEDMILNWFTQMCLGVNHI 118
Query: 198 HSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENG 257
H +RV+HRDIK N+F+T G VKLGD G R S+ A + VGTPYY+ PE
Sbjct: 119 HKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLP 178
Query: 258 YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVS 317
YN KSDIWSLGC+LYE+ L+ PF + +L K+ Q PLP HYS +L+ LV
Sbjct: 179 YNNKSDIWSLGCILYELCTLKHPFQANSWK--NLILKVCQGCISPLP-SHYSYELQFLVK 235
Query: 318 MCICPDPHQRP 328
+P RP
Sbjct: 236 QMFKRNPSHRP 246
>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 175 bits (443), Expect = 6e-44
Identities = 98/251 (39%), Positives = 140/251 (55%), Gaps = 7/251 (2%)
Query: 78 DFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHP 137
D+ + + IG G F + A+K++++ + Q+ KE LL ++ HP
Sbjct: 3 DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNT--QNSRKEAVLLAKMKHP 60
Query: 138 NIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHM 197
NI+ + +SF + L IV+E D GDL Q IK +++ +L PE + +F Q+C V H+
Sbjct: 61 NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIK--QQKGKLFPEDMILNWFTQMCLGVNHI 118
Query: 198 HSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENG 257
H +RV+HRDIK N+F+T G VKLGD G R S+ A + VGTPYY+ PE
Sbjct: 119 HKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLP 178
Query: 258 YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVS 317
YN KSDIWSLGC+LYE+ L+ PF + +L K+ Q PLP HYS +L+ LV
Sbjct: 179 YNNKSDIWSLGCILYELCTLKHPFQANSWK--NLILKVCQGCISPLP-SHYSYELQFLVK 235
Query: 318 MCICPDPHQRP 328
+P RP
Sbjct: 236 QMFKRNPSHRP 246
>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 175 bits (443), Expect = 6e-44
Identities = 98/251 (39%), Positives = 140/251 (55%), Gaps = 7/251 (2%)
Query: 78 DFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHP 137
D+ + + IG G F + A+K++++ + Q+ KE LL ++ HP
Sbjct: 3 DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNT--QNSRKEAVLLAKMKHP 60
Query: 138 NIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHM 197
NI+ + +SF + L IV+E D GDL Q IK +++ +L PE + +F Q+C V H+
Sbjct: 61 NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIK--QQKGKLFPEDMILNWFTQMCLGVNHI 118
Query: 198 HSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENG 257
H +RV+HRDIK N+F+T G VKLGD G R S+ A + VGTPYY+ PE
Sbjct: 119 HKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLP 178
Query: 258 YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVS 317
YN KSDIWSLGC+LYE+ L+ PF + +L K+ Q PLP HYS +L+ LV
Sbjct: 179 YNNKSDIWSLGCILYELCTLKHPFQANSWK--NLILKVCQGCISPLP-SHYSYELQFLVK 235
Query: 318 MCICPDPHQRP 328
+P RP
Sbjct: 236 QMFKRNPSHRP 246
>gi|4505373 NIMA-related kinase 2 [Homo sapiens]
Length = 445
Score = 173 bits (439), Expect = 2e-43
Identities = 98/260 (37%), Positives = 148/260 (56%), Gaps = 11/260 (4%)
Query: 78 DFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHP 137
D+++ IG G + K D K + K++ M +A+ +Q V E+ LL++L HP
Sbjct: 7 DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAE-KQMLVSEVNLLRELKHP 65
Query: 138 NIIKYLDSFIE--DNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVE 195
NI++Y D I+ + L IV+E + GDL+ +I K+++ + E V + QL A++
Sbjct: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125
Query: 196 HMHSRR-----VMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSP 250
H R V+HRD+KPANVF+ VKLGD GL R + +T+ A + VGTPYYMSP
Sbjct: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185
Query: 251 ERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSE 310
E+++ YN KSDIWSLGCLLYE+ AL PF L KI + + +P YS+
Sbjct: 186 EQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQK--ELAGKIREGKFRRIP-YRYSD 242
Query: 311 KLRELVSMCICPDPHQRPDI 330
+L E+++ + + RP +
Sbjct: 243 ELNEIITRMLNLKDYHRPSV 262
>gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens]
Length = 470
Score = 167 bits (423), Expect = 1e-41
Identities = 95/269 (35%), Positives = 150/269 (55%), Gaps = 18/269 (6%)
Query: 66 HPNTLSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTV------ALKKVQIFEMMDAK 119
+P TL R + +++K+G G F VY + D+K LK++ + E+ +
Sbjct: 20 YPKTLIAR----RYVLQQKLGSGSFGTVYLVS---DKKAKRGEELKVLKEISVGELNPNE 72
Query: 120 ARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIP 179
Q + E LL +L+HP I+K+ SF+E + I+ E + DL I+ +K+ ++ P
Sbjct: 73 TVQANL-EAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFP 131
Query: 180 ERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAH 239
E + ++F+QL V++MH RR++HRD+K NVF+ ++K+GD G+ R A
Sbjct: 132 ENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLAT 190
Query: 240 SLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCD 299
+L GTP+YMSPE + GY+ KSDIWSL C+LYEM + F G N S+ KI + D
Sbjct: 191 TLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGS--NFLSIVLKIVEGD 248
Query: 300 YPPLPGEHYSEKLRELVSMCICPDPHQRP 328
P LP E Y ++L ++ + +P RP
Sbjct: 249 TPSLP-ERYPKELNAIMESMLNKNPSLRP 276
>gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens]
Length = 599
Score = 167 bits (423), Expect = 1e-41
Identities = 95/269 (35%), Positives = 150/269 (55%), Gaps = 18/269 (6%)
Query: 66 HPNTLSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTV------ALKKVQIFEMMDAK 119
+P TL R + +++K+G G F VY + D+K LK++ + E+ +
Sbjct: 20 YPKTLIAR----RYVLQQKLGSGSFGTVYLVS---DKKAKRGEELKVLKEISVGELNPNE 72
Query: 120 ARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIP 179
Q + E LL +L+HP I+K+ SF+E + I+ E + DL I+ +K+ ++ P
Sbjct: 73 TVQANL-EAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFP 131
Query: 180 ERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAH 239
E + ++F+QL V++MH RR++HRD+K NVF+ ++K+GD G+ R A
Sbjct: 132 ENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLAT 190
Query: 240 SLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCD 299
+L GTP+YMSPE + GY+ KSDIWSL C+LYEM + F G N S+ KI + D
Sbjct: 191 TLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGS--NFLSIVLKIVEGD 248
Query: 300 YPPLPGEHYSEKLRELVSMCICPDPHQRP 328
P LP E Y ++L ++ + +P RP
Sbjct: 249 TPSLP-ERYPKELNAIMESMLNKNPSLRP 276
>gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens]
Length = 645
Score = 167 bits (423), Expect = 1e-41
Identities = 95/269 (35%), Positives = 150/269 (55%), Gaps = 18/269 (6%)
Query: 66 HPNTLSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTV------ALKKVQIFEMMDAK 119
+P TL R + +++K+G G F VY + D+K LK++ + E+ +
Sbjct: 20 YPKTLIAR----RYVLQQKLGSGSFGTVYLVS---DKKAKRGEELKVLKEISVGELNPNE 72
Query: 120 ARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIP 179
Q + E LL +L+HP I+K+ SF+E + I+ E + DL I+ +K+ ++ P
Sbjct: 73 TVQANL-EAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFP 131
Query: 180 ERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAH 239
E + ++F+QL V++MH RR++HRD+K NVF+ ++K+GD G+ R A
Sbjct: 132 ENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLAT 190
Query: 240 SLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCD 299
+L GTP+YMSPE + GY+ KSDIWSL C+LYEM + F G N S+ KI + D
Sbjct: 191 TLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGS--NFLSIVLKIVEGD 248
Query: 300 YPPLPGEHYSEKLRELVSMCICPDPHQRP 328
P LP E Y ++L ++ + +P RP
Sbjct: 249 TPSLP-ERYPKELNAIMESMLNKNPSLRP 276
>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
Length = 979
Score = 167 bits (422), Expect = 2e-41
Identities = 96/245 (39%), Positives = 139/245 (56%), Gaps = 6/245 (2%)
Query: 85 IGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLD 144
+GRG F E D V K+V + + + K R+D + EI +L L H NII Y +
Sbjct: 58 LGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSE-KERRDALNEIVILALLQHDNIIAYYN 116
Query: 145 SFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMH 204
F+++ L I LE + G+L K +++ +L E V Y Q+ SAV +H ++H
Sbjct: 117 HFMDNTTLLIELEYCNGGNLYD--KILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILH 174
Query: 205 RDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDI 264
RDIK N+F+T ++KLGD GL + +SE + A +LVGTPYYMSPE YNFKSDI
Sbjct: 175 RDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDI 234
Query: 265 WSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQ-CDYPPLPGEHYSEKLRELVSMCICPD 323
W++GC+++E+ L+ F D N +LC KI Q + YS +L ++V C+ D
Sbjct: 235 WAVGCVIFELLTLKRTF--DATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQD 292
Query: 324 PHQRP 328
P QRP
Sbjct: 293 PEQRP 297
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 147 bits (371), Expect = 1e-35
Identities = 92/258 (35%), Positives = 140/258 (54%), Gaps = 15/258 (5%)
Query: 79 FQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPN 138
+ + + IG G F VYK + VALK + + + R + +EI +++ L HPN
Sbjct: 4 YHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELR-NLQREIEIMRGLRHPN 62
Query: 139 IIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMH 198
I+ LDSF D E+ +V + A+ G+L Q+++ K +PE V QL SA+ ++H
Sbjct: 63 IVHMLDSFETDKEVVVVTDYAE-GELFQILEDDGK----LPEDQVQAIAAQLVSALYYLH 117
Query: 199 SRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGY 258
S R++HRD+KP N+ + G +KL D G R S+ T S+ GTP YMSPE + E Y
Sbjct: 118 SHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPY 177
Query: 259 NFKSDIWSLGCLLYEMAALQSPFYGDKM-NLFSLCQKIEQCDYPPLPGEHYSEKLRELVS 317
+ +D+WS+GC+LYE+A PFY + L SL K + +P + L+ L++
Sbjct: 178 DHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILK-DPVRWPSTISPCFKNFLQGLLT 236
Query: 318 MCICPDPHQR---PDIGY 332
DP QR PD+ Y
Sbjct: 237 ----KDPRQRLSWPDLLY 250
>gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo
sapiens]
Length = 1328
Score = 144 bits (364), Expect = 9e-35
Identities = 88/255 (34%), Positives = 135/255 (52%), Gaps = 19/255 (7%)
Query: 85 IGRGQFSEVYKATCLLDRK--TVALKKVQIFEMMDAKARQDCVK---EIGLLKQLNHPNI 139
+G+G + VY C L + +A+K+V + A ++ K E+ LLK L H NI
Sbjct: 1067 LGKGAYGTVY---CGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNI 1123
Query: 140 IKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHS 199
+ YL + +++N ++I +E G +S +I F +PE KY Q+ V ++H
Sbjct: 1124 VAYLGTCLQENTVSIFMEFVPGGSISSIINRFGP----LPEMVFCKYTKQILQGVAYLHE 1179
Query: 200 RRVMHRDIKPANVFITATGVVKLGDLGLGRFFS------SETTAAHSLVGTPYYMSPERI 253
V+HRDIK NV + TG++KL D G R + + + S+ GTPY+M+PE I
Sbjct: 1180 NCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVI 1239
Query: 254 HENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLR 313
+E+GY KSDIWS+GC ++EMA + P + PPLP +H+SE
Sbjct: 1240 NESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLP-DHFSENAA 1298
Query: 314 ELVSMCICPDPHQRP 328
+ V MC+ D H+RP
Sbjct: 1299 DFVRMCLTRDQHERP 1313
>gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo
sapiens]
Length = 510
Score = 144 bits (364), Expect = 9e-35
Identities = 88/255 (34%), Positives = 135/255 (52%), Gaps = 19/255 (7%)
Query: 85 IGRGQFSEVYKATCLLDRK--TVALKKVQIFEMMDAKARQDCVK---EIGLLKQLNHPNI 139
+G+G + VY C L + +A+K+V + A ++ K E+ LLK L H NI
Sbjct: 249 LGKGAYGTVY---CGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNI 305
Query: 140 IKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHS 199
+ YL + +++N ++I +E G +S +I F +PE KY Q+ V ++H
Sbjct: 306 VAYLGTCLQENTVSIFMEFVPGGSISSIINRFGP----LPEMVFCKYTKQILQGVAYLHE 361
Query: 200 RRVMHRDIKPANVFITATGVVKLGDLGLGRFFS------SETTAAHSLVGTPYYMSPERI 253
V+HRDIK NV + TG++KL D G R + + + S+ GTPY+M+PE I
Sbjct: 362 NCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVI 421
Query: 254 HENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLR 313
+E+GY KSDIWS+GC ++EMA + P + PPLP +H+SE
Sbjct: 422 NESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLP-DHFSENAA 480
Query: 314 ELVSMCICPDPHQRP 328
+ V MC+ D H+RP
Sbjct: 481 DFVRMCLTRDQHERP 495
>gi|4759208 TAO kinase 2 isoform 1 [Homo sapiens]
Length = 1049
Score = 136 bits (342), Expect = 3e-32
Identities = 83/249 (33%), Positives = 130/249 (52%), Gaps = 13/249 (5%)
Query: 83 KKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKY 142
++IG G F VY A + + + VA+KK+ + QD +KE+ L++L HPN I+Y
Sbjct: 32 REIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQY 91
Query: 143 LDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRV 202
++ ++ +V+E G S +++ KK + + V +Q + ++HS +
Sbjct: 92 RGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAVTHGALQ---GLAYLHSHNM 147
Query: 203 MHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERI---HENGYN 259
+HRD+K N+ ++ G+VKLGD G +S A+S VGTPY+M+PE I E Y+
Sbjct: 148 IHRDVKAGNILLSEPGLVKLGDFG----SASIMAPANSFVGTPYWMAPEVILAMDEGQYD 203
Query: 260 FKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMC 319
K D+WSLG E+A + P + MN S I Q + P L H+SE R V C
Sbjct: 204 GKVDVWSLGITCIELAERKPPLF--NMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSC 261
Query: 320 ICPDPHQRP 328
+ P RP
Sbjct: 262 LQKIPQDRP 270
>gi|45505130 TAO kinase 2 isoform 2 [Homo sapiens]
Length = 1235
Score = 136 bits (342), Expect = 3e-32
Identities = 83/249 (33%), Positives = 130/249 (52%), Gaps = 13/249 (5%)
Query: 83 KKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKY 142
++IG G F VY A + + + VA+KK+ + QD +KE+ L++L HPN I+Y
Sbjct: 32 REIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQY 91
Query: 143 LDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRV 202
++ ++ +V+E G S +++ KK + + V +Q + ++HS +
Sbjct: 92 RGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAVTHGALQ---GLAYLHSHNM 147
Query: 203 MHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERI---HENGYN 259
+HRD+K N+ ++ G+VKLGD G +S A+S VGTPY+M+PE I E Y+
Sbjct: 148 IHRDVKAGNILLSEPGLVKLGDFG----SASIMAPANSFVGTPYWMAPEVILAMDEGQYD 203
Query: 260 FKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMC 319
K D+WSLG E+A + P + MN S I Q + P L H+SE R V C
Sbjct: 204 GKVDVWSLGITCIELAERKPPLF--NMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSC 261
Query: 320 ICPDPHQRP 328
+ P RP
Sbjct: 262 LQKIPQDRP 270
>gi|148746218 TAO kinase 3 [Homo sapiens]
Length = 898
Score = 133 bits (334), Expect = 3e-31
Identities = 85/250 (34%), Positives = 127/250 (50%), Gaps = 17/250 (6%)
Query: 84 KIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYL 143
+IG G F VY AT + VA+KK+ + QD +KE+ L+QL HPN I+Y
Sbjct: 29 EIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQLKHPNTIEYK 88
Query: 144 DSFIEDNELNIVLE--LADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRR 201
+++++ +V+E L A DL ++ K+ + E + + ++HS
Sbjct: 89 GCYLKEHTAWLVMEYCLGSASDLLEV------HKKPLQEVEIAAITHGALHGLAYLHSHA 142
Query: 202 VMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERI---HENGY 258
++HRDIK N+ +T G VKL D G +S + A+S VGTPY+M+PE I E Y
Sbjct: 143 LIHRDIKAGNILLTEPGQVKLADFG----SASMASPANSFVGTPYWMAPEVILAMDEGQY 198
Query: 259 NFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSM 318
+ K DIWSLG E+A + P + MN S I Q D P L +++ R V
Sbjct: 199 DGKVDIWSLGITCIELAERKPPLF--NMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDY 256
Query: 319 CICPDPHQRP 328
C+ P +RP
Sbjct: 257 CLQKIPQERP 266
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 131 bits (329), Expect = 1e-30
Identities = 86/287 (29%), Positives = 145/287 (50%), Gaps = 30/287 (10%)
Query: 42 MPHGGSSNNLCHTLGPVHPPDPQRHPNTLSFRCSLADFQIEKKIGRGQFSEVYKATCLLD 101
+PH G S NL DP+ L +KIG+G F EV+K
Sbjct: 19 LPHPGGSTNL--------KADPEELFTKL------------EKIGKGSFGEVFKGIDNRT 58
Query: 102 RKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADA 161
+K VA+K + + E D +D +EI +L Q + P + KY S+++D +L I++E
Sbjct: 59 QKVVAIKIIDLEEAEDEI--EDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGG 116
Query: 162 GDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVK 221
G ++ + + E + ++ ++++HS + +HRDIK ANV ++ G VK
Sbjct: 117 GSALDLL-----EPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVK 171
Query: 222 LGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPF 281
L D G+ + ++ VGTP++M+PE I ++ Y+ K+DIWSLG E+A + P
Sbjct: 172 LADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPH 231
Query: 282 YGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICPDPHQRP 328
+++ + I + + P L G +YS+ L+E V C+ +P RP
Sbjct: 232 --SELHPMKVLFLIPKNNPPTLEG-NYSKPLKEFVEACLNKEPSFRP 275
>gi|45439370 TAO kinase 1 [Homo sapiens]
Length = 1001
Score = 131 bits (329), Expect = 1e-30
Identities = 80/249 (32%), Positives = 127/249 (51%), Gaps = 13/249 (5%)
Query: 83 KKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKY 142
++IG G F VY A + + VA+KK+ + QD +KE+ L+++ HPN I+Y
Sbjct: 32 REIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIEY 91
Query: 143 LDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRV 202
++ ++ +V+E G S +++ KK + + + +Q + ++HS +
Sbjct: 92 KGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAITHGALQ---GLAYLHSHTM 147
Query: 203 MHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERI---HENGYN 259
+HRDIK N+ +T G VKL D G +S + A+S VGTPY+M+PE I E Y+
Sbjct: 148 IHRDIKAGNILLTEPGQVKLADFG----SASMASPANSFVGTPYWMAPEVILAMDEGQYD 203
Query: 260 FKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMC 319
K D+WSLG E+A + P + MN S I Q + P L +S+ R V C
Sbjct: 204 GKVDVWSLGITCIELAERKPPLF--NMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSC 261
Query: 320 ICPDPHQRP 328
+ P RP
Sbjct: 262 LQKIPQDRP 270
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 131 bits (329), Expect = 1e-30
Identities = 79/245 (32%), Positives = 133/245 (54%), Gaps = 10/245 (4%)
Query: 84 KIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYL 143
+IG+G F EVYK ++ VA+K + + E D +D +EI +L Q + P I +Y
Sbjct: 25 RIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEI--EDIQQEITVLSQCDSPYITRYF 82
Query: 144 DSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVM 203
S+++ +L I++E G ++K ++ I T+ + ++ ++++HS R +
Sbjct: 83 GSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIA--TILR---EILKGLDYLHSERKI 137
Query: 204 HRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSD 263
HRDIK ANV ++ G VKL D G+ + ++ VGTP++M+PE I ++ Y+FK+D
Sbjct: 138 HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKAD 197
Query: 264 IWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICPD 323
IWSLG E+A + P ++ + I + P L G+H S+ +E V C+ D
Sbjct: 198 IWSLGITAIELAKGEPP--NSDLHPMRVLFLIPKNSPPTLEGQH-SKPFKEFVEACLNKD 254
Query: 324 PHQRP 328
P RP
Sbjct: 255 PRFRP 259
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 130 bits (327), Expect = 2e-30
Identities = 77/246 (31%), Positives = 134/246 (54%), Gaps = 10/246 (4%)
Query: 83 KKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKY 142
+KIG+G F EV+K +K VA+K + + E D +D +EI +L Q + P + KY
Sbjct: 28 EKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEI--EDIQQEITVLSQCDSPYVTKY 85
Query: 143 LDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRV 202
S+++D +L I++E G ++ + + E + ++ ++++HS +
Sbjct: 86 YGSYLKDTKLWIIMEYLGGGSALDLL-----EPGPLDETQIATILREILKGLDYLHSEKK 140
Query: 203 MHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKS 262
+HRDIK ANV ++ G VKL D G+ + ++ VGTP++M+PE I ++ Y+ K+
Sbjct: 141 IHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKA 200
Query: 263 DIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICP 322
DIWSLG E+A + P +++ + I + + P L G +YS+ L+E V C+
Sbjct: 201 DIWSLGITAIELARGEPPH--SELHPMKVLFLIPKNNPPTLEG-NYSKPLKEFVEACLNK 257
Query: 323 DPHQRP 328
+P RP
Sbjct: 258 EPSFRP 263
>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
Length = 298
Score = 129 bits (324), Expect = 4e-30
Identities = 86/235 (36%), Positives = 119/235 (50%), Gaps = 11/235 (4%)
Query: 76 LADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLN 135
+ +FQ +KIG G + VYKA L + VALKK+++ + ++EI LLK+LN
Sbjct: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEG-VPSTAIREISLLKELN 59
Query: 136 HPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRL--IPERTVWKYFVQLCSA 193
HPNI+K LD +N+L +V E L Q +K F L IP + Y QL
Sbjct: 60 HPNIVKLLDVIHTENKLYLVFEF-----LHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114
Query: 194 VEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPE-R 252
+ HS RV+HRD+KP N+ I G +KL D GL R F V T +Y +PE
Sbjct: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 174
Query: 253 IHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKM--NLFSLCQKIEQCDYPPLPG 305
+ Y+ DIWSLGC+ EM ++ F GD LF + + + D PG
Sbjct: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 129 bits (324), Expect = 4e-30
Identities = 76/251 (30%), Positives = 132/251 (52%), Gaps = 13/251 (5%)
Query: 79 FQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPN 138
F + +K+G G + VYKA + VA+K+V + + Q+ +KEI +++Q + P+
Sbjct: 30 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDL-----QEIIKEISIMQQCDSPH 84
Query: 139 IIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMH 198
++KY S+ ++ +L IV+E AG +S +I+ + + + E + +E++H
Sbjct: 85 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRL---RNKTLTEDEIATILQSTLKGLEYLH 141
Query: 199 SRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGY 258
R +HRDIK N+ + G KL D G+ + ++++GTP++M+PE I E GY
Sbjct: 142 FMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGY 201
Query: 259 NFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPL--PGEHYSEKLRELV 316
N +DIWSLG EMA + P Y D + ++ + + PP E +S+ + V
Sbjct: 202 NCVADIWSLGITAIEMAEGKPP-YADIHPMRAIF--MIPTNPPPTFRKPELWSDNFTDFV 258
Query: 317 SMCICPDPHQR 327
C+ P QR
Sbjct: 259 KQCLVKSPEQR 269
>gi|55956904 mitogen-activated protein kinase kinase kinase 4 isoform
a [Homo sapiens]
Length = 1608
Score = 129 bits (323), Expect = 5e-30
Identities = 78/274 (28%), Positives = 142/274 (51%), Gaps = 18/274 (6%)
Query: 63 PQRHPNTLSFRCSLADFQIEK--KIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKA 120
P+ + N + F+ ++ KIG GQ+ +VY + + +A+K+++ F+ D K
Sbjct: 1325 PKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIR-FQPNDHKT 1383
Query: 121 RQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPE 180
++ E+ + + + HPN+++Y + E+ I +E D G L ++ + + E
Sbjct: 1384 IKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLG------LQE 1437
Query: 181 RTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTA--- 237
+ Y Q+ A+ +H ++HRDIK AN+F+T++G++KLGD G +
Sbjct: 1438 HVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPG 1497
Query: 238 -AHSLVGTPYYMSPE---RIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQ 293
+S +GT YM+PE R G+ +DIWSLGC++ EM + P++ + N F +
Sbjct: 1498 EVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHN-FQIMY 1556
Query: 294 KIEQCDYPPLPGEHYSEKLRELVSMCICPDPHQR 327
K+ PP+P E S + ++ +S C+ DP R
Sbjct: 1557 KVGMGHKPPIP-ERLSPEGKDFLSHCLESDPKMR 1589
>gi|55956902 mitogen-activated protein kinase kinase kinase 4 isoform
b [Homo sapiens]
Length = 1558
Score = 129 bits (323), Expect = 5e-30
Identities = 78/274 (28%), Positives = 142/274 (51%), Gaps = 18/274 (6%)
Query: 63 PQRHPNTLSFRCSLADFQIEK--KIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKA 120
P+ + N + F+ ++ KIG GQ+ +VY + + +A+K+++ F+ D K
Sbjct: 1275 PKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIR-FQPNDHKT 1333
Query: 121 RQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPE 180
++ E+ + + + HPN+++Y + E+ I +E D G L ++ + + E
Sbjct: 1334 IKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLG------LQE 1387
Query: 181 RTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTA--- 237
+ Y Q+ A+ +H ++HRDIK AN+F+T++G++KLGD G +
Sbjct: 1388 HVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPG 1447
Query: 238 -AHSLVGTPYYMSPE---RIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQ 293
+S +GT YM+PE R G+ +DIWSLGC++ EM + P++ + N F +
Sbjct: 1448 EVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHN-FQIMY 1506
Query: 294 KIEQCDYPPLPGEHYSEKLRELVSMCICPDPHQR 327
K+ PP+P E S + ++ +S C+ DP R
Sbjct: 1507 KVGMGHKPPIP-ERLSPEGKDFLSHCLESDPKMR 1539
>gi|4826878 oxidative-stress responsive 1 [Homo sapiens]
Length = 527
Score = 128 bits (322), Expect = 7e-30
Identities = 74/269 (27%), Positives = 140/269 (52%), Gaps = 22/269 (8%)
Query: 78 DFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHP 137
D+++++ IG G + V A C ++ VA+K++ + + + + +KEI + Q +HP
Sbjct: 16 DYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSM--DELLKEIQAMSQCHHP 73
Query: 138 NIIKYLDSFIEDNELNIVLELADAGDLSQMIKYF----KKQKRLIPERTVWKYFVQLCSA 193
NI+ Y SF+ +EL +V++L G + +IK+ + + ++ E T+ ++
Sbjct: 74 NIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEG 133
Query: 194 VEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFS-----SETTAAHSLVGTPYYM 248
+E++H +HRD+K N+ + G V++ D G+ F + + + VGTP +M
Sbjct: 134 LEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWM 193
Query: 249 SPERIHE-NGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPG-- 305
+PE + + GY+FK+DIWS G E+A +P++ K + Q D P L
Sbjct: 194 APEVMEQVRGYDFKADIWSFGITAIELATGAAPYH--KYPPMKVLMLTLQNDPPSLETGV 251
Query: 306 ------EHYSEKLRELVSMCICPDPHQRP 328
+ Y + R+++S+C+ DP +RP
Sbjct: 252 QDKEMLKKYGKSFRKMISLCLQKDPEKRP 280
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.432
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,858,865
Number of Sequences: 37866
Number of extensions: 697905
Number of successful extensions: 4026
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 735
Number of HSP's successfully gapped in prelim test: 63
Number of HSP's that attempted gapping in prelim test: 1519
Number of HSP's gapped (non-prelim): 907
length of query: 347
length of database: 18,247,518
effective HSP length: 103
effective length of query: 244
effective length of database: 14,347,320
effective search space: 3500746080
effective search space used: 3500746080
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.