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Search of human proteins with 221307502
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|221307502 WEE1 tyrosine kinase isoform 2 [Homo sapiens]
(432 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|221307502 WEE1 tyrosine kinase isoform 2 [Homo sapiens] 860 0.0
gi|4507917 WEE1 tyrosine kinase isoform 1 [Homo sapiens] 860 0.0
gi|157738687 WEE1 homolog 2 [Homo sapiens] 422 e-118
gi|33383239 protein kinase Myt1 isoform 2 [Homo sapiens] 148 1e-35
gi|33383241 protein kinase Myt1 isoform 1 [Homo sapiens] 148 1e-35
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 100 3e-21
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 96 8e-20
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 94 2e-19
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 94 3e-19
gi|148839316 NIMA-related kinase 4 [Homo sapiens] 92 7e-19
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 92 7e-19
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 92 1e-18
gi|19424132 NIMA-related kinase 7 [Homo sapiens] 86 7e-17
gi|41872673 NIMA-related kinase 1 [Homo sapiens] 84 3e-16
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens] 82 7e-16
gi|41872374 polo-like kinase 3 [Homo sapiens] 82 1e-15
gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens] 81 2e-15
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens] 81 2e-15
gi|83627721 NIMA-related kinase 5 [Homo sapiens] 81 2e-15
gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens] 79 6e-15
gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens] 79 6e-15
gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens] 79 6e-15
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 79 8e-15
gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens] 78 2e-14
gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens] 78 2e-14
gi|109255245 serine/threonine kinase 17a [Homo sapiens] 77 2e-14
gi|4758128 doublecortin-like kinase 1 [Homo sapiens] 77 3e-14
gi|93004081 polo-like kinase 2 [Homo sapiens] 77 4e-14
gi|4507831 Unc-51-like kinase 1 [Homo sapiens] 76 7e-14
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 76 7e-14
>gi|221307502 WEE1 tyrosine kinase isoform 2 [Homo sapiens]
Length = 432
Score = 860 bits (2222), Expect = 0.0
Identities = 432/432 (100%), Positives = 432/432 (100%)
Query: 1 MDTEKSGKREFDVRQTPQVNINPFTPDSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYEL 60
MDTEKSGKREFDVRQTPQVNINPFTPDSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYEL
Sbjct: 1 MDTEKSGKREFDVRQTPQVNINPFTPDSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYEL 60
Query: 61 EDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPL 120
EDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPL
Sbjct: 61 EDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPL 120
Query: 121 AGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRI 180
AGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRI
Sbjct: 121 AGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRI 180
Query: 181 MSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWAS 240
MSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWAS
Sbjct: 181 MSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWAS 240
Query: 241 NKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAE 300
NKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAE
Sbjct: 241 NKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAE 300
Query: 301 PLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASR 360
PLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASR
Sbjct: 301 PLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASR 360
Query: 361 KSAEQLRIELNAEKFKNSLLQKELKKAQMAKAAAEERALFTDRMATRSTTQSNRTSRLIG 420
KSAEQLRIELNAEKFKNSLLQKELKKAQMAKAAAEERALFTDRMATRSTTQSNRTSRLIG
Sbjct: 361 KSAEQLRIELNAEKFKNSLLQKELKKAQMAKAAAEERALFTDRMATRSTTQSNRTSRLIG 420
Query: 421 KKMNRSVSLTIY 432
KKMNRSVSLTIY
Sbjct: 421 KKMNRSVSLTIY 432
>gi|4507917 WEE1 tyrosine kinase isoform 1 [Homo sapiens]
Length = 646
Score = 860 bits (2222), Expect = 0.0
Identities = 432/432 (100%), Positives = 432/432 (100%)
Query: 1 MDTEKSGKREFDVRQTPQVNINPFTPDSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYEL 60
MDTEKSGKREFDVRQTPQVNINPFTPDSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYEL
Sbjct: 215 MDTEKSGKREFDVRQTPQVNINPFTPDSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYEL 274
Query: 61 EDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPL 120
EDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPL
Sbjct: 275 EDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPL 334
Query: 121 AGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRI 180
AGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRI
Sbjct: 335 AGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRI 394
Query: 181 MSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWAS 240
MSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWAS
Sbjct: 395 MSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWAS 454
Query: 241 NKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAE 300
NKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAE
Sbjct: 455 NKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAE 514
Query: 301 PLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASR 360
PLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASR
Sbjct: 515 PLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASR 574
Query: 361 KSAEQLRIELNAEKFKNSLLQKELKKAQMAKAAAEERALFTDRMATRSTTQSNRTSRLIG 420
KSAEQLRIELNAEKFKNSLLQKELKKAQMAKAAAEERALFTDRMATRSTTQSNRTSRLIG
Sbjct: 575 KSAEQLRIELNAEKFKNSLLQKELKKAQMAKAAAEERALFTDRMATRSTTQSNRTSRLIG 634
Query: 421 KKMNRSVSLTIY 432
KKMNRSVSLTIY
Sbjct: 635 KKMNRSVSLTIY 646
>gi|157738687 WEE1 homolog 2 [Homo sapiens]
Length = 567
Score = 422 bits (1084), Expect = e-118
Identities = 229/419 (54%), Positives = 289/419 (68%), Gaps = 19/419 (4%)
Query: 19 VNINPFTPDS---LLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITES 75
VNINPFTP+S L L S G+ + R D+E + E PAKR + E+
Sbjct: 153 VNINPFTPESYKKLFLQSGGKRKIRG----------DLEEAGPEEGKGGLPAKRCVLRET 202
Query: 76 NMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYA 135
NM SRY EF E+EKIG GEFG+V+KC+KRLDGC+YAIKRS K +E +AL EVYA
Sbjct: 203 NMASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYA 262
Query: 136 HAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQ 195
HAVLG H HVVRY+S+WAEDDHM+IQNEYCNGGSL AISEN + ++F+E +LKD+LLQ
Sbjct: 263 HAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQ 322
Query: 196 VGRGLRYIHSMSLVHMDIKPSNIFI---SRTSIPNAASEEGDEDDW-ASNKVMFKIGDLG 251
+ GL YIH+ S+VH+DIKPSNIFI ++ E +E DW S VM+KIGDLG
Sbjct: 323 ISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLG 382
Query: 252 HVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHE 311
H T I+ P+VEEGDSRFLANE+LQE+Y HLPKADIFAL LT+ AAGAE LP NG WH
Sbjct: 383 HATSINKPKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHH 442
Query: 312 IRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELN 371
IR+G P +PQ LS+ F+ LLK MI PD E+RPSA AL +++VL + K+ E+L+ +LN
Sbjct: 443 IRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAALARNTVLRPSLGKT-EELQQQLN 501
Query: 372 AEKFKNSLLQKELKKAQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLT 430
EKFK + L++EL++AQ A+ + + D + + T S T RL+G K RS S T
Sbjct: 502 LEKFKTATLERELREAQQAQ-SPQGYTHHGDTGVSGTHTGSRSTKRLVGGKSARSSSFT 559
>gi|33383239 protein kinase Myt1 isoform 2 [Homo sapiens]
Length = 480
Score = 148 bits (373), Expect = 1e-35
Identities = 101/292 (34%), Positives = 143/292 (48%), Gaps = 43/292 (14%)
Query: 75 SNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVY 134
S +S + F L ++G G +G VFK + DG +YA+KRS P G D L EV
Sbjct: 100 SRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVG 159
Query: 135 AHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCN----------GGSLADAISENYRIMSYF 184
+H +GQH VR AW E + +Q E C G SL +A Y
Sbjct: 160 SHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGY------ 213
Query: 185 KEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVM 244
L+D LL L ++HS LVH+D+KP+NIF+ P + GD
Sbjct: 214 ----LRDTLL----ALAHLHSQGLVHLDVKPANIFLG----PRGRCKLGD---------- 251
Query: 245 FKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPR 304
G L + + +V+EGD R++A E+LQ +Y AD+F+L LT++ A LP
Sbjct: 252 --FGLLVELGTAGAGEVQEGDPRYMAPELLQGSYG--TAADVFSLGLTILEVACNMELPH 307
Query: 305 NGDQWHEIRQGRL-PRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVL 355
G+ W ++RQG L P LS E +L +M+ PDP+ R +A AL+ VL
Sbjct: 308 GGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVL 359
>gi|33383241 protein kinase Myt1 isoform 1 [Homo sapiens]
Length = 499
Score = 148 bits (373), Expect = 1e-35
Identities = 101/292 (34%), Positives = 143/292 (48%), Gaps = 43/292 (14%)
Query: 75 SNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVY 134
S +S + F L ++G G +G VFK + DG +YA+KRS P G D L EV
Sbjct: 100 SRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVG 159
Query: 135 AHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCN----------GGSLADAISENYRIMSYF 184
+H +GQH VR AW E + +Q E C G SL +A Y
Sbjct: 160 SHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGY------ 213
Query: 185 KEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVM 244
L+D LL L ++HS LVH+D+KP+NIF+ P + GD
Sbjct: 214 ----LRDTLL----ALAHLHSQGLVHLDVKPANIFLG----PRGRCKLGD---------- 251
Query: 245 FKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPR 304
G L + + +V+EGD R++A E+LQ +Y AD+F+L LT++ A LP
Sbjct: 252 --FGLLVELGTAGAGEVQEGDPRYMAPELLQGSYG--TAADVFSLGLTILEVACNMELPH 307
Query: 305 NGDQWHEIRQGRL-PRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVL 355
G+ W ++RQG L P LS E +L +M+ PDP+ R +A AL+ VL
Sbjct: 308 GGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVL 359
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 100 bits (249), Expect = 3e-21
Identities = 79/289 (27%), Positives = 138/289 (47%), Gaps = 40/289 (13%)
Query: 85 FHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSH 144
F +LE+IG G FG VFK + + AIK L + DE +++ S+
Sbjct: 24 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIID--LEEAEDEIEDIQQEITVLSQCDSSY 81
Query: 145 VVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIH 204
V +Y+ ++ + + I EY GGS D + F E ++ +L ++ +GL Y+H
Sbjct: 82 VTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGP-----FDEFQIATMLKEILKGLDYLH 136
Query: 205 SMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEE- 263
S +H DIK +N+ + SE+GD K+ D G +++ Q++
Sbjct: 137 SEKKIHRDIKAANVLL---------SEQGD----------VKLADFGVAGQLTDTQIKRN 177
Query: 264 ---GDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIR------Q 314
G ++A EV+Q++ + KADI++L +T + A E P N D H +R +
Sbjct: 178 TFVGTPFWMAPEVIQQS-AYDSKADIWSLGITAIELAKGE--PPNSDM-HPMRVLFLIPK 233
Query: 315 GRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSA 363
P + ++ F E + ++ DP RP+A L+KH ++ S+K++
Sbjct: 234 NNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTS 282
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 95.5 bits (236), Expect = 8e-20
Identities = 94/371 (25%), Positives = 165/371 (44%), Gaps = 64/371 (17%)
Query: 72 ITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALR 131
+ E ++ + F LEK+G G +GSV+K + + G I AIK+ V ++ L+
Sbjct: 17 LDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQ--------VPVESDLQ 68
Query: 132 EVYAHAVLGQH---SHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAE 188
E+ + Q HVV+Y+ ++ ++ + I EYC GS++D I + ++ E E
Sbjct: 69 EIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLT---EDE 125
Query: 189 LKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIG 248
+ +L +GL Y+H M +H DIK NI + + EG K+
Sbjct: 126 IATILQSTLKGLEYLHFMRKIHRDIKAGNILL---------NTEGHA----------KLA 166
Query: 249 DLGHVTRISSPQVEE----GDSRFLANEVLQE-NYTHLPKADIFALALTVVCAAGAEP-- 301
D G +++ + G ++A EV+QE Y + ADI++L +T + A +P
Sbjct: 167 DFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCV--ADIWSLGITAIEMAEGKPPY 224
Query: 302 ---LPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSA 358
P R P++ S FT+ +K + PE+R +A L++H + SA
Sbjct: 225 ADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSA 284
Query: 359 ----------------SRKSAEQLRIELNAEKFKNSLLQKELKKAQMAKAAAEERALFTD 402
K E + E++ + +NS + E+ M +A +E + T
Sbjct: 285 KGVSILRDLINEAMDVKLKRQESQQREVDQDDEENS-EEDEMDSGTMVRAVGDE--MGTV 341
Query: 403 RMATRSTTQSN 413
R+A+ T +N
Sbjct: 342 RVASTMTDGAN 352
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 94.0 bits (232), Expect = 2e-19
Identities = 76/299 (25%), Positives = 142/299 (47%), Gaps = 40/299 (13%)
Query: 75 SNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVY 134
+N+K+ F +LEKIG G FG VFK + + AIK L + DE +++
Sbjct: 26 TNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIID--LEEAEDEIEDIQQEI 83
Query: 135 AHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLL 194
+V +Y+ ++ +D + I EY GGS D + E ++ +L
Sbjct: 84 TVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGP-----LDETQIATILR 138
Query: 195 QVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVT 254
++ +GL Y+HS +H DIK +N+ + SE G+ K+ D G
Sbjct: 139 EILKGLDYLHSEKKIHRDIKAANVLL---------SEHGE----------VKLADFGVAG 179
Query: 255 RISSPQVEE----GDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWH 310
+++ Q++ G ++A EV++++ + KADI++L +T + A EP P + + H
Sbjct: 180 QLTDTQIKRNTFVGTPFWMAPEVIKQS-AYDSKADIWSLGITAIELARGEP-PHS--ELH 235
Query: 311 EIR------QGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSA 363
++ + P + S+ E ++ ++ +P RP+A L+KH +L ++K++
Sbjct: 236 PMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTS 294
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 93.6 bits (231), Expect = 3e-19
Identities = 76/298 (25%), Positives = 141/298 (47%), Gaps = 40/298 (13%)
Query: 76 NMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYA 135
N+K+ F +LEKIG G FG VFK + + AIK L + DE +++
Sbjct: 15 NLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIID--LEEAEDEIEDIQQEIT 72
Query: 136 HAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQ 195
+V +Y+ ++ +D + I EY GGS D + E ++ +L +
Sbjct: 73 VLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGP-----LDETQIATILRE 127
Query: 196 VGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTR 255
+ +GL Y+HS +H DIK +N+ + SE G+ K+ D G +
Sbjct: 128 ILKGLDYLHSEKKIHRDIKAANVLL---------SEHGE----------VKLADFGVAGQ 168
Query: 256 ISSPQVEE----GDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHE 311
++ Q++ G ++A EV++++ + KADI++L +T + A EP P + + H
Sbjct: 169 LTDTQIKRNTFVGTPFWMAPEVIKQS-AYDSKADIWSLGITAIELARGEP-PHS--ELHP 224
Query: 312 IR------QGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSA 363
++ + P + S+ E ++ ++ +P RP+A L+KH +L ++K++
Sbjct: 225 MKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTS 282
>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
Length = 841
Score = 92.4 bits (228), Expect = 7e-19
Identities = 75/298 (25%), Positives = 132/298 (44%), Gaps = 31/298 (10%)
Query: 88 LEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVR 147
L +G G +G V R DG Y IK+ A S + + A +E + L +H ++V
Sbjct: 9 LRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL-KHPNIVT 67
Query: 148 YFSAWAEDDHML-IQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSM 206
Y +W D +L I +C GG L + E + E ++ + +Q+ L+Y+H
Sbjct: 68 YKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQL--LPENQVVEWFVQIAMALQYLHEK 125
Query: 207 SLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDS 266
++H D+K N+F++RT+I K+GDLG + R+ + +
Sbjct: 126 HILHRDLKTQNVFLTRTNI-------------------IKVGDLG-IARVLENHCDMAST 165
Query: 267 R----FLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQ---WHEIRQGRLPR 319
+ + L N + K+D++AL V A + D + I +G+LP
Sbjct: 166 LIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPP 225
Query: 320 IPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKN 377
+P+ S E EL++ M+ PE RPS ++++ + E +I+ + KN
Sbjct: 226 MPRDYSPELAELIRTMLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKN 283
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 92.4 bits (228), Expect = 7e-19
Identities = 88/349 (25%), Positives = 162/349 (46%), Gaps = 56/349 (16%)
Query: 60 LEDETRPAKRIT-ITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKK 118
+E P ++ ++E ++ + F LEK+G G +GSVFK + + G + AIK+
Sbjct: 1 MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQ--- 57
Query: 119 PLAGSVDEQNALREVYAHAVLGQH---SHVVRYFSAWAEDDHMLIQNEYCNGGSLADAIS 175
V ++ L+E+ + Q +VV+Y+ ++ ++ + I EYC GS++D I
Sbjct: 58 -----VPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR 112
Query: 176 ENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDE 235
+ + E E+ +L +GL Y+H M +H DIK NI + + EG
Sbjct: 113 LRNKTLI---EDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILL---------NTEGHA 160
Query: 236 DDWASNKVMFKIGDLGHVTRISSPQVEE----GDSRFLANEVLQE-NYTHLPKADIFALA 290
K+ D G +++ + G ++A EV+QE Y + ADI++L
Sbjct: 161 ----------KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCV--ADIWSLG 208
Query: 291 LTVVCAAGAEP-----LPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPS 345
+T + A +P P R P++ S +FT+ +K + +PE+R +
Sbjct: 209 ITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRAT 268
Query: 346 AMALVKHSVLLSASRKSAEQLR------IELNAEKFKNSLLQKELKKAQ 388
A L++H + +A K LR +E+ A++ + Q+EL++ +
Sbjct: 269 ATQLLQHPFIKNA--KPVSILRDLITEAMEIKAKRHEEQ--QRELEEEE 313
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 91.7 bits (226), Expect = 1e-18
Identities = 79/301 (26%), Positives = 140/301 (46%), Gaps = 42/301 (13%)
Query: 75 SNMKSRYTTE--FHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALRE 132
+N SR E F +L++IG G FG V+K + + AIK L + DE +++
Sbjct: 8 ANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIID--LEEAEDEIEDIQQ 65
Query: 133 VYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDL 192
++ RYF ++ + + I EY GGS D + +E + +
Sbjct: 66 EITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGP-----LEETYIATI 120
Query: 193 LLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGH 252
L ++ +GL Y+HS +H DIK +N+ + SE+GD K+ D G
Sbjct: 121 LREILKGLDYLHSERKIHRDIKAANVLL---------SEQGD----------VKLADFGV 161
Query: 253 VTRISSPQVEE----GDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQ 308
+++ Q++ G ++A EV++++ KADI++L +T + A E P N D
Sbjct: 162 AGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDF-KADIWSLGITAIELAKGE--PPNSD- 217
Query: 309 WHEIR------QGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKS 362
H +R + P + S+ F E ++ ++ DP RP+A L+KH + ++K+
Sbjct: 218 LHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKT 277
Query: 363 A 363
+
Sbjct: 278 S 278
>gi|19424132 NIMA-related kinase 7 [Homo sapiens]
Length = 302
Score = 85.9 bits (211), Expect = 7e-17
Identities = 72/274 (26%), Positives = 128/274 (46%), Gaps = 46/274 (16%)
Query: 89 EKIGSGEFGSVFKCVKRLDGCIYAIKRSK-------KPLAGSVDEQNALREVYAHAVLGQ 141
+KIG G+F V++ LDG A+K+ + K A + E + L+++
Sbjct: 38 KKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQL-------N 90
Query: 142 HSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLR 201
H +V++Y++++ ED+ + I E + G L+ I + E + +Q+ L
Sbjct: 91 HPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALE 150
Query: 202 YIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQV 261
++HS ++H DIKP+N+FI+ T + K+GDLG SS
Sbjct: 151 HMHSRRVMHRDIKPANVFITATGV-------------------VKLGDLGLGRFFSSKTT 191
Query: 262 EE----GDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWH------E 311
G +++ E + EN + K+DI++L + A + P GD+ + +
Sbjct: 192 AAHSLVGTPYYMSPERIHENGYNF-KSDIWSLGCLLYEMAALQS-PFYGDKMNLYSLCKK 249
Query: 312 IRQGRLPRIP-QVLSQEFTELLKVMIHPDPERRP 344
I Q P +P S+E +L+ + I+PDPE+RP
Sbjct: 250 IEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRP 283
>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
Length = 1258
Score = 83.6 bits (205), Expect = 3e-16
Identities = 72/300 (24%), Positives = 135/300 (45%), Gaps = 35/300 (11%)
Query: 84 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHS 143
++ L+KIG G FG DG Y IK S + + + REV A + +H
Sbjct: 3 KYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANM-KHP 61
Query: 144 HVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYI 203
++V+Y ++ E+ + I +YC GG L I+ ++ F+E ++ D +Q+ L+++
Sbjct: 62 NIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVL--FQEDQILDWFVQICLALKHV 119
Query: 204 HSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVE- 262
H ++H DIK NIF+++ ++GD G + R+ + VE
Sbjct: 120 HDRKILHRDIKSQNIFLTKDG-------------------TVQLGDFG-IARVLNSTVEL 159
Query: 263 ----EGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWH---EIRQG 315
G +L+ E+ EN + K+DI+AL + + G + +I G
Sbjct: 160 ARTCIGTPYYLSPEIC-ENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISG 218
Query: 316 RLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKF 375
P + S + L+ + +P RPS ++++ + +++ + L +L AE+F
Sbjct: 219 SFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILEKGFI---AKRIEKFLSPQLIAEEF 275
>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
Length = 489
Score = 82.4 bits (202), Expect = 7e-16
Identities = 89/363 (24%), Positives = 156/363 (42%), Gaps = 49/363 (13%)
Query: 84 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHS 143
++ L IG G FG ++A+K + P + S + QN+ +E A + +H
Sbjct: 3 DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFS-NTQNSRKEAVLLAKM-KHP 60
Query: 144 HVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYI 203
++V + ++ + H+ I EYC+GG L I + F E + + Q+ G+ +I
Sbjct: 61 NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKG--KLFPEDMILNWFTQMCLGVNHI 118
Query: 204 HSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQ--- 260
H ++H DIK NIF+++ + KV K+GD G +S+P
Sbjct: 119 HKKRVLHRDIKSKNIFLTQ-----------------NGKV--KLGDFGSARLLSNPMAFA 159
Query: 261 -VEEGDSRFLANEVLQENYTHLPKADIFALA--LTVVCAAGAEPLPRNGDQWH----EIR 313
G ++ E+ EN + K+DI++L L +C P + W ++
Sbjct: 160 CTYVGTPYYVPPEI-WENLPYNNKSDIWSLGCILYELCTL---KHPFQANSWKNLILKVC 215
Query: 314 QGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRI----E 369
QG + +P S E L+K M +P RPSA L+ ++ +K I E
Sbjct: 216 QGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGE 275
Query: 370 LNAEKFKNS---LLQKELKKAQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRS 426
E+ KNS +K+ ++ Q K + + + + + + NR +K N+S
Sbjct: 276 EVLEEIKNSKHNTPRKKQEEEQDRKGSHTDLESINENLVESALRRVNRE-----EKGNKS 330
Query: 427 VSL 429
V L
Sbjct: 331 VHL 333
>gi|41872374 polo-like kinase 3 [Homo sapiens]
Length = 646
Score = 81.6 bits (200), Expect = 1e-15
Identities = 68/270 (25%), Positives = 119/270 (44%), Gaps = 34/270 (12%)
Query: 91 IGSGEFGSVFKCVKRLDGCIYAIKR-SKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYF 149
+G G F ++ G YA+K + +A + L E+ H L QH H+VR+
Sbjct: 68 LGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDL-QHRHIVRFS 126
Query: 150 SAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLV 209
+ + D++ I E C+ SLA + ++ E E++ L Q+ GL+Y+H ++
Sbjct: 127 HHFEDADNIYIFLELCSRKSLAHIWKARHTLL----EPEVRYYLRQILSGLKYLHQRGIL 182
Query: 210 HMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEE----GD 265
H D+K N FI + + K+GD G R+ P+ + G
Sbjct: 183 HRDLKLGNFFI-------------------TENMELKVGDFGLAARLEPPEQRKKTICGT 223
Query: 266 SRFLANEVLQENYTHLPKADIFALA---LTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQ 322
++A EVL H P+AD+++L T++C + + + I+Q +P
Sbjct: 224 PNYVAPEVLLRQ-GHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHY-TLPA 281
Query: 323 VLSQEFTELLKVMIHPDPERRPSAMALVKH 352
LS +LL ++ P RPS +++H
Sbjct: 282 SLSLPARQLLAAILRASPRDRPSIDQILRH 311
>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 81.3 bits (199), Expect = 2e-15
Identities = 73/288 (25%), Positives = 127/288 (44%), Gaps = 37/288 (12%)
Query: 84 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHS 143
++ L IG G FG ++A+K + P + S + QN+ +E A + +H
Sbjct: 3 DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFS-NTQNSRKEAVLLAKM-KHP 60
Query: 144 HVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYI 203
++V + ++ + H+ I EYC+GG L I + F E + + Q+ G+ +I
Sbjct: 61 NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKG--KLFPEDMILNWFTQMCLGVNHI 118
Query: 204 HSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQ--- 260
H ++H DIK NIF+++ + KV K+GD G +S+P
Sbjct: 119 HKKRVLHRDIKSKNIFLTQ-----------------NGKV--KLGDFGSARLLSNPMAFA 159
Query: 261 -VEEGDSRFLANEVLQENYTHLPKADIFALA--LTVVCAAGAEPLPRNGDQWH----EIR 313
G ++ E+ EN + K+DI++L L +C P + W ++
Sbjct: 160 CTYVGTPYYVPPEI-WENLPYNNKSDIWSLGCILYELCTL---KHPFQANSWKNLILKVC 215
Query: 314 QGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRK 361
QG + +P S E L+K M +P RPSA L+ ++ +K
Sbjct: 216 QGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLLSRGIVARLVQK 263
>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 81.3 bits (199), Expect = 2e-15
Identities = 73/288 (25%), Positives = 127/288 (44%), Gaps = 37/288 (12%)
Query: 84 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHS 143
++ L IG G FG ++A+K + P + S + QN+ +E A + +H
Sbjct: 3 DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFS-NTQNSRKEAVLLAKM-KHP 60
Query: 144 HVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYI 203
++V + ++ + H+ I EYC+GG L I + F E + + Q+ G+ +I
Sbjct: 61 NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKG--KLFPEDMILNWFTQMCLGVNHI 118
Query: 204 HSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQ--- 260
H ++H DIK NIF+++ + KV K+GD G +S+P
Sbjct: 119 HKKRVLHRDIKSKNIFLTQ-----------------NGKV--KLGDFGSARLLSNPMAFA 159
Query: 261 -VEEGDSRFLANEVLQENYTHLPKADIFALA--LTVVCAAGAEPLPRNGDQWH----EIR 313
G ++ E+ EN + K+DI++L L +C P + W ++
Sbjct: 160 CTYVGTPYYVPPEI-WENLPYNNKSDIWSLGCILYELCTL---KHPFQANSWKNLILKVC 215
Query: 314 QGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRK 361
QG + +P S E L+K M +P RPSA L+ ++ +K
Sbjct: 216 QGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLLSRGIVARLVQK 263
>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
Length = 708
Score = 81.3 bits (199), Expect = 2e-15
Identities = 78/309 (25%), Positives = 137/309 (44%), Gaps = 42/309 (13%)
Query: 84 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKR---SKKPLAGSVDEQNALREVYAHAVLG 140
++ ++ IG G FG + + D IK K P + E+ A ++
Sbjct: 3 KYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMP----IQEKEASKKEVILLEKM 58
Query: 141 QHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGL 200
+H ++V +F+++ E+ + I EYC+GG L I+ ++ F E ++ +Q+ GL
Sbjct: 59 KHPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVL--FSEDQILGWFVQISLGL 116
Query: 201 RYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQ 260
++IH ++H DIK NIF+S+ N ++ K+GD G + R+ +
Sbjct: 117 KHIHDRKILHRDIKAQNIFLSK------------------NGMVAKLGDFG-IARVLNNS 157
Query: 261 VE-----EGDSRFLANEVLQENYTHLPKADIFAL--ALTVVCAAGAEPLPRNGDQW--HE 311
+E G +L+ E+ Q N + K DI++L L +C P N Q +
Sbjct: 158 MELARTCIGTPYYLSPEICQ-NKPYNNKTDIWSLGCVLYELCTL-KHPFEGNNLQQLVLK 215
Query: 312 IRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELN 371
I Q I S+E L+ + P RPS +++K L + K L E+
Sbjct: 216 ICQAHFAPISPGFSRELHSLISQLFQVSPRDRPSINSILKRPFLENLIPK---YLTPEVI 272
Query: 372 AEKFKNSLL 380
E+F + L+
Sbjct: 273 QEEFSHMLI 281
>gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens]
Length = 470
Score = 79.3 bits (194), Expect = 6e-15
Identities = 67/277 (24%), Positives = 129/277 (46%), Gaps = 40/277 (14%)
Query: 89 EKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSH--VV 146
+K+GSG FG+V+ + +K K+ G ++ ++ +L + H +V
Sbjct: 33 QKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIV 92
Query: 147 RYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSM 206
++ +++ E D+ I EYC G L D I E + F E ++ + +Q+ G+ Y+H
Sbjct: 93 KFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHER 152
Query: 207 SLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVE---- 262
++H D+K N+F+ + KIGD G V+R+ +
Sbjct: 153 RILHRDLKSKNVFLKNN--------------------LLKIGDFG-VSRLLMGSCDLATT 191
Query: 263 -EGDSRFLANEVLQENYTHLPKADIFALA--LTVVCA-----AGAEPLPRNGDQWHEIRQ 314
G +++ E L ++ + K+DI++LA L +C AG+ L +I +
Sbjct: 192 LTGTPHYMSPEAL-KHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFL----SIVLKIVE 246
Query: 315 GRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVK 351
G P +P+ +E +++ M++ +P RPSA+ ++K
Sbjct: 247 GDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILK 283
>gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens]
Length = 599
Score = 79.3 bits (194), Expect = 6e-15
Identities = 67/277 (24%), Positives = 129/277 (46%), Gaps = 40/277 (14%)
Query: 89 EKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSH--VV 146
+K+GSG FG+V+ + +K K+ G ++ ++ +L + H +V
Sbjct: 33 QKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIV 92
Query: 147 RYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSM 206
++ +++ E D+ I EYC G L D I E + F E ++ + +Q+ G+ Y+H
Sbjct: 93 KFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHER 152
Query: 207 SLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVE---- 262
++H D+K N+F+ + KIGD G V+R+ +
Sbjct: 153 RILHRDLKSKNVFLKNN--------------------LLKIGDFG-VSRLLMGSCDLATT 191
Query: 263 -EGDSRFLANEVLQENYTHLPKADIFALA--LTVVCA-----AGAEPLPRNGDQWHEIRQ 314
G +++ E L ++ + K+DI++LA L +C AG+ L +I +
Sbjct: 192 LTGTPHYMSPEAL-KHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFL----SIVLKIVE 246
Query: 315 GRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVK 351
G P +P+ +E +++ M++ +P RPSA+ ++K
Sbjct: 247 GDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILK 283
>gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens]
Length = 645
Score = 79.3 bits (194), Expect = 6e-15
Identities = 67/277 (24%), Positives = 129/277 (46%), Gaps = 40/277 (14%)
Query: 89 EKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSH--VV 146
+K+GSG FG+V+ + +K K+ G ++ ++ +L + H +V
Sbjct: 33 QKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIV 92
Query: 147 RYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSM 206
++ +++ E D+ I EYC G L D I E + F E ++ + +Q+ G+ Y+H
Sbjct: 93 KFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHER 152
Query: 207 SLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVE---- 262
++H D+K N+F+ + KIGD G V+R+ +
Sbjct: 153 RILHRDLKSKNVFLKNN--------------------LLKIGDFG-VSRLLMGSCDLATT 191
Query: 263 -EGDSRFLANEVLQENYTHLPKADIFALA--LTVVCA-----AGAEPLPRNGDQWHEIRQ 314
G +++ E L ++ + K+DI++LA L +C AG+ L +I +
Sbjct: 192 LTGTPHYMSPEAL-KHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFL----SIVLKIVE 246
Query: 315 GRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVK 351
G P +P+ +E +++ M++ +P RPSA+ ++K
Sbjct: 247 GDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILK 283
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 79.0 bits (193), Expect = 8e-15
Identities = 78/305 (25%), Positives = 139/305 (45%), Gaps = 53/305 (17%)
Query: 90 KIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYF 149
++G G FG V+K + G + A K + +++ E+ A H ++V+
Sbjct: 41 ELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATC---DHPYIVKLL 97
Query: 150 SAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLV 209
A+ D + I E+C GG++ + E R ++ E +++ + Q+ L ++HS ++
Sbjct: 98 GAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLT---EPQIQVVCRQMLEALNFLHSKRII 154
Query: 210 HMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDS--- 266
H D+K N+ ++ EGD ++ D G V+ + +++ DS
Sbjct: 155 HRDLKAGNVLMTL---------EGD----------IRLADFG-VSAKNLKTLQKRDSFIG 194
Query: 267 --RFLANEVLQ-ENYTHLP---KADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRL--- 317
++A EV+ E P KADI++L +T++ A EP HE+ R+
Sbjct: 195 TPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEP------PHHELNPMRVLLK 248
Query: 318 ------PRI--PQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLS-ASRKSAEQLRI 368
P + P S EF + LK+ + +PE RPSA L++H + S S K+ +L
Sbjct: 249 IAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVA 308
Query: 369 ELNAE 373
E AE
Sbjct: 309 EAKAE 313
>gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]
Length = 347
Score = 77.8 bits (190), Expect = 2e-14
Identities = 69/273 (25%), Positives = 126/273 (46%), Gaps = 34/273 (12%)
Query: 84 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKK-PLAGSVDEQNALREVYAHAVLGQH 142
+F +KIG G+F V+K LD A+K+ + + + Q+ ++E+ L H
Sbjct: 78 DFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLN-H 136
Query: 143 SHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRY 202
++++Y ++ ED+ + I E + G L+ I + E + +Q+ + +
Sbjct: 137 PNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEH 196
Query: 203 IHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVE 262
+HS ++H DIKP+N+FI+ T + K+GDLG SS
Sbjct: 197 MHSRRVMHRDIKPANVFITATGV-------------------VKLGDLGLGRFFSSETTA 237
Query: 263 E----GDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWH------EI 312
G +++ E + EN + K+DI++L + A + P GD+ + +I
Sbjct: 238 AHSLVGTPYYMSPERIHENGYNF-KSDIWSLGCLLYEMAALQS-PFYGDKMNLFSLCQKI 295
Query: 313 RQGRLPRIP-QVLSQEFTELLKVMIHPDPERRP 344
Q P +P + S++ EL+ + I PDP +RP
Sbjct: 296 EQCDYPPLPGEHYSEKLRELVSMCICPDPHQRP 328
>gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]
Length = 313
Score = 77.8 bits (190), Expect = 2e-14
Identities = 69/273 (25%), Positives = 126/273 (46%), Gaps = 34/273 (12%)
Query: 84 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKK-PLAGSVDEQNALREVYAHAVLGQH 142
+F +KIG G+F V+K LD A+K+ + + + Q+ ++E+ L H
Sbjct: 44 DFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLN-H 102
Query: 143 SHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRY 202
++++Y ++ ED+ + I E + G L+ I + E + +Q+ + +
Sbjct: 103 PNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEH 162
Query: 203 IHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVE 262
+HS ++H DIKP+N+FI+ T + K+GDLG SS
Sbjct: 163 MHSRRVMHRDIKPANVFITATGV-------------------VKLGDLGLGRFFSSETTA 203
Query: 263 E----GDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWH------EI 312
G +++ E + EN + K+DI++L + A + P GD+ + +I
Sbjct: 204 AHSLVGTPYYMSPERIHENGYNF-KSDIWSLGCLLYEMAALQS-PFYGDKMNLFSLCQKI 261
Query: 313 RQGRLPRIP-QVLSQEFTELLKVMIHPDPERRP 344
Q P +P + S++ EL+ + I PDP +RP
Sbjct: 262 EQCDYPPLPGEHYSEKLRELVSMCICPDPHQRP 294
>gi|109255245 serine/threonine kinase 17a [Homo sapiens]
Length = 414
Score = 77.4 bits (189), Expect = 2e-14
Identities = 73/281 (25%), Positives = 130/281 (46%), Gaps = 32/281 (11%)
Query: 90 KIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYF 149
++G G+F V KC+K+ G +A K +K G + E+ + + V+
Sbjct: 66 ELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLH 125
Query: 150 SAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLV 209
+ M++ EY GG + D + FKE +++ L+ Q+ G+ ++H+ +V
Sbjct: 126 EVYETASEMILVLEYAAGGEIFDQCVADRE--EAFKEKDVQRLMRQILEGVHFLHTRDVV 183
Query: 210 HMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRI--SSPQVEE--GD 265
H+D+KP NI ++ + S GD KI D G ++RI +S ++ E G
Sbjct: 184 HLDLKPQNILLT------SESPLGD----------IKIVDFG-LSRILKNSEELREIMGT 226
Query: 266 SRFLANEVLQENYTHLPKA-DIFAL-ALTVVCAAGAEPLPRNGDQ--WHEIRQGRLPRIP 321
++A E+L +Y + A D++++ LT V G P N Q + I Q L
Sbjct: 227 PEYVAPEIL--SYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSE 284
Query: 322 Q---VLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSAS 359
+ VLS+ + ++ ++ PE R +A +KH L +S
Sbjct: 285 EEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWLTQSS 325
>gi|4758128 doublecortin-like kinase 1 [Homo sapiens]
Length = 729
Score = 77.0 bits (188), Expect = 3e-14
Identities = 82/322 (25%), Positives = 138/322 (42%), Gaps = 60/322 (18%)
Query: 46 NDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKR 105
ND GE++ +++ PA TITE R IG G F V +CV+R
Sbjct: 368 NDGPGEEVSEEGFQI-----PA---TITERYKVGR---------TIGDGNFAVVKECVER 410
Query: 106 LDGCIYAIKRSKKPLAGSVD-----EQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLI 160
YA+K KK + E + LR V +H ++V + +
Sbjct: 411 STAREYALKIIKKSKCRGKEHMIQNEVSILRRV-------KHPNIVLLIEEMDVPTELYL 463
Query: 161 QNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFI 220
E GG L DAI+ + + E + +L + ++Y+HS+++VH DIKP N+ +
Sbjct: 464 VMELVKGGDLFDAITSTNK----YTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLV 519
Query: 221 SRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEE-GDSRFLANEVLQENYT 279
++G + K+GD G T + P G ++A E++ E
Sbjct: 520 YE-------HQDGSKS--------LKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGY 564
Query: 280 HLPKADIFAL-ALTVVCAAGAEPLPRNGDQ----WHEIRQGRLPRIPQV----LSQEFTE 330
L K DI+A +T + G P +GD + +I G++ P +S E
Sbjct: 565 GL-KVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVD-FPSPYWDNVSDSAKE 622
Query: 331 LLKVMIHPDPERRPSAMALVKH 352
L+ +M+ D ++R SA+ +++H
Sbjct: 623 LITMMLLVDVDQRFSAVQVLEH 644
>gi|93004081 polo-like kinase 2 [Homo sapiens]
Length = 685
Score = 76.6 bits (187), Expect = 4e-14
Identities = 67/274 (24%), Positives = 118/274 (43%), Gaps = 34/274 (12%)
Query: 91 IGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNAL-REVYAHAVLGQHSHVVRYF 149
+G G F ++ + +YA K ++ + +E+ H +L H HVV+++
Sbjct: 88 LGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRIL-HHKHVVQFY 146
Query: 150 SAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLV 209
+ + +++ I EYC+ S+A + + E E++ L Q+ GL+Y+H ++
Sbjct: 147 HYFEDKENIYILLEYCSRRSMAHIL----KARKVLTEPEVRYYLRQIVSGLKYLHEQEIL 202
Query: 210 HMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEE----GD 265
H D+K N FI N A E K+GD G R+ + G
Sbjct: 203 HRDLKLGNFFI------NEAME-------------LKVGDFGLAARLEPLEHRRRTICGT 243
Query: 266 SRFLANEVLQENYTHLPKADIFALALTV-VCAAGAEPLPRNG--DQWHEIRQGRLPRIPQ 322
+L+ EVL + H ++DI+AL + G P + + IR+ R +P
Sbjct: 244 PNYLSPEVLNKQ-GHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARY-TMPS 301
Query: 323 VLSQEFTELLKVMIHPDPERRPSAMALVKHSVLL 356
L L+ M+ +PE RPS +++H L
Sbjct: 302 SLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFL 335
>gi|4507831 Unc-51-like kinase 1 [Homo sapiens]
Length = 1050
Score = 75.9 bits (185), Expect = 7e-14
Identities = 73/276 (26%), Positives = 120/276 (43%), Gaps = 40/276 (14%)
Query: 84 EFHELEKIGSGEFGSVFKCVKR----LDGCIYAIKRSKKPLAGSVD----EQNALREVYA 135
EF + IG G F VFK R L+ + I +KK LA S E L+E+
Sbjct: 15 EFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCI--NKKNLAKSQTLLGKEIKILKEL-- 70
Query: 136 HAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQ 195
+H ++V + + + + EYCNGG LAD + M E ++ L Q
Sbjct: 71 -----KHENIVALYDFQEMANSVYLVMEYCNGGDLADYL----HAMRTLSEDTIRLFLQQ 121
Query: 196 VGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTR 255
+ +R +HS ++H D+KP NI +S N A + N + KI D G
Sbjct: 122 IAGAMRLLHSKGIIHRDLKPQNILLS-----NPAGRRAN-----PNSIRVKIADFGFARY 171
Query: 256 ISSPQVEE---GDSRFLANEVLQENYTHLPKADIFALALTVV-CAAGAEPLPRNGDQ--- 308
+ S + G ++A EV+ + + KAD++++ V C G P + Q
Sbjct: 172 LQSNMMAATLCGSPMYMAPEVIMSQH-YDGKADLWSIGTIVYQCLTGKAPFQASSPQDLR 230
Query: 309 -WHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERR 343
++E + +P IP+ S +LL ++ + + R
Sbjct: 231 LFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDR 266
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 75.9 bits (185), Expect = 7e-14
Identities = 79/331 (23%), Positives = 137/331 (41%), Gaps = 49/331 (14%)
Query: 61 EDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPL 120
++E R ++ + K +YT EKIG G G+V+ + G AIK+
Sbjct: 263 DEEILEKLRSIVSVGDPKKKYT----RFEKIGQGASGTVYTALDIATGQEVAIKQMNL-- 316
Query: 121 AGSVDEQNALREVYAHAVL----GQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISE 176
+Q +E+ + +L ++ ++V Y ++ D + + EY GGSL D ++E
Sbjct: 317 -----QQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTE 371
Query: 177 NYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDED 236
+ E ++ + + + L ++HS ++H DIK NI +
Sbjct: 372 -----TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDG------------ 414
Query: 237 DWASNKVMFKIGDLGHVTRISSPQVEE----GDSRFLANEVLQENYTHLPKADIFALALT 292
K+ D G +I+ Q + G ++A EV+ + PK DI++L +
Sbjct: 415 -------SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRK-AYGPKVDIWSLGIM 466
Query: 293 VVCAAGAEPLPRNGD---QWHEIRQGRLPRI--PQVLSQEFTELLKVMIHPDPERRPSAM 347
+ EP N + + I P + P+ LS F + L + D +RR SA
Sbjct: 467 AIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAK 526
Query: 348 ALVKHSVLLSASRKSAEQLRIELNAEKFKNS 378
L++H L A S+ I E KNS
Sbjct: 527 ELLQHPFLKLAKPLSSLTPLIIAAKEAIKNS 557
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.131 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,333,961
Number of Sequences: 37866
Number of extensions: 666467
Number of successful extensions: 3548
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 491
Number of HSP's successfully gapped in prelim test: 236
Number of HSP's that attempted gapping in prelim test: 2212
Number of HSP's gapped (non-prelim): 904
length of query: 432
length of database: 18,247,518
effective HSP length: 105
effective length of query: 327
effective length of database: 14,271,588
effective search space: 4666809276
effective search space used: 4666809276
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.