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Search of human proteins with 21735550
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21735550 mitogen-activated protein kinase kinase kinase 10
[Homo sapiens]
(954 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 1954 0.0
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho... 979 0.0
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 811 0.0
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 721 0.0
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 280 5e-75
gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho... 260 5e-69
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 225 2e-58
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 225 2e-58
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 184 4e-46
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso... 184 4e-46
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso... 184 4e-46
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof... 184 4e-46
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 155 2e-37
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 155 2e-37
gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens] 139 1e-32
gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens] 139 1e-32
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] 139 1e-32
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] 139 1e-32
gi|4503787 fyn-related kinase [Homo sapiens] 139 1e-32
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 133 7e-31
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 133 7e-31
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 133 7e-31
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 132 1e-30
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 132 1e-30
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 132 1e-30
gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo sa... 132 1e-30
gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo sa... 132 1e-30
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 132 2e-30
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 132 2e-30
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 132 2e-30
>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
sapiens]
Length = 954
Score = 1954 bits (5063), Expect = 0.0
Identities = 954/954 (100%), Positives = 954/954 (100%)
Query: 1 MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWT 60
MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWT
Sbjct: 1 MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWT 60
Query: 61 GQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGE 120
GQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGE
Sbjct: 61 GQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGE 120
Query: 121 EVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGG 180
EVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGG
Sbjct: 121 EVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGG 180
Query: 181 ALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLA 240
ALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLA
Sbjct: 181 ALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLA 240
Query: 241 DTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGE 300
DTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGE
Sbjct: 241 DTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGE 300
Query: 301 VPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVI 360
VPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVI
Sbjct: 301 VPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVI 360
Query: 361 EQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLR 420
EQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLR
Sbjct: 361 EQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLR 420
Query: 421 RREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGF 480
RREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGF
Sbjct: 421 RREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGF 480
Query: 481 EHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSR 540
EHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSR
Sbjct: 481 EHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSR 540
Query: 541 GGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHT 600
GGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHT
Sbjct: 541 GGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHT 600
Query: 601 PIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPP 660
PIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPP
Sbjct: 601 PIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPP 660
Query: 661 ARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRG 720
ARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRG
Sbjct: 661 ARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRG 720
Query: 721 LSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSP 780
LSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSP
Sbjct: 721 LSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSP 780
Query: 781 PAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPP 840
PAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPP
Sbjct: 781 PAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPP 840
Query: 841 EPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWK 900
EPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWK
Sbjct: 841 EPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWK 900
Query: 901 LVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH 954
LVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH
Sbjct: 901 LVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH 954
>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
sapiens]
Length = 1118
Score = 979 bits (2532), Expect = 0.0
Identities = 582/1086 (53%), Positives = 697/1086 (64%), Gaps = 157/1086 (14%)
Query: 2 EEEEGAVAK---EWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGW 58
EEEE A A E G P WTAVF+YEAAG++ELTLR GD V+VLS+D VSGDEGW
Sbjct: 35 EEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGW 94
Query: 59 WTGQLPSGRVGVFPSNYVAPGA------------PAAPAGLQLPQEIPFHELQLEEIIGV 106
WTGQL + RVG+FPSNYV P + P+ +QL EI F EL LEEIIG+
Sbjct: 95 WTGQL-NQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQL-LEIDFAELTLEEIIGI 152
Query: 107 GGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLN 166
GGFGKVYRA W G+EVAVKAAR DP++D + T E V QEA+LF L+HPNIIALRG CL
Sbjct: 153 GGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLK 212
Query: 167 PPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSI 226
P+LCLVME+ARGG L+RVL+G+R+PP +LVNWAVQ+ARGMNYLH++A VPIIHRDLKS
Sbjct: 213 EPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSS 272
Query: 227 NILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDV 286
NILIL+ +EN +L++ +LKITDFGLAREWH+TTKMSAAGTYAWMAPEVIR S+FSK SDV
Sbjct: 273 NILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDV 332
Query: 287 WSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHG 346
WS+GVLLWELLTGEVP+R ID LAVAYGVAMNKL LPIPSTCPEPFA+L+E+CW+PDPH
Sbjct: 333 WSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHS 392
Query: 347 RPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELL 406
RP F +IL +L IE+S F+MP +SFH LQ++WK EIQ MFD LR KEKELR+ EEEL
Sbjct: 393 RPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELT 452
Query: 407 RAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLK 466
RAA +Q+ QEE LRRREQELAERE+DI+EREL++++ QL QEKPRV+KRKG F++SR LK
Sbjct: 453 RAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSR-LK 511
Query: 467 LREGGSHISLPSGFEHKITVQASPTLDKRKG--SDGASPPASPSIIPRLRAIRLTPVDCG 524
L++ G+ ISLPS F+HK TVQASPT+DKRK + +SPPASP+IIPRLRAI+LTP +
Sbjct: 512 LKD-GNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGE-- 568
Query: 525 GSSSGSSSGGSGTWSRGG-PPK----KEELVGGKKKGRTWGPSSTLQKERVGGEE----- 574
S TW R PK +EE KKKGRTWGP + QKE G+E
Sbjct: 569 ---------SSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQR 619
Query: 575 ------------------RLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEM---- 612
LK L +G KQWSSSAPNL K P+ +P PGF SL EM
Sbjct: 620 REKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMALLA 679
Query: 613 ---------EEFAEAEDGGSSVPPSPYS-TPSYLSVPLP--------------AEPSPGA 648
EE ++E GS +S + SYL +P P EP+P
Sbjct: 680 ASWVVPIDIEEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVN 739
Query: 649 RAPWEP--TPSAPPARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAAD-------- 698
A P TP+ R G RRC++ALLGC +L A GLG D+ EA
Sbjct: 740 SATSTPQLTPTNSLKR-GGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPE 798
Query: 699 --GEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLG-LAPSATLVSLSSVSDC 755
E+++ +GL F R+ R R SPP+R ++E+ LG + S TL+SLSS+S+C
Sbjct: 799 PPAREEKKRREGL-FQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISEC 857
Query: 756 NSTRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPST-NPLVDLELESFKKDPRQSLTPTH 814
NSTRSLLRSDSDE P P P SP T NPLV++ +E FK+DP QSLTPTH
Sbjct: 858 NSTRSLLRSDSDE---IVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTH 914
Query: 815 VTAAC-AVSRGHRRTPSDGALGQR-----GPPEPAGHGPGP-----------RDLLDFPR 857
VT + HRRTPSDGAL P G P P RD +FPR
Sbjct: 915 VTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPR 974
Query: 858 LPDPQALFPARRR-----PPEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLTISP 912
LPDP +FP R RP TL F PRPRP+A+R RLDPW VS + SP
Sbjct: 975 LPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSP 1034
Query: 913 --PSRPDTP---------------ESPGPPSVQP-----------TLLDMDMEGQNQDST 944
S +TP E PG P++ P TLLD+D EGQ+QDST
Sbjct: 1035 ANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDST 1094
Query: 945 VPLCGA 950
VPLC A
Sbjct: 1095 VPLCRA 1100
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 811 bits (2094), Expect = 0.0
Identities = 492/1013 (48%), Positives = 624/1013 (61%), Gaps = 107/1013 (10%)
Query: 13 GTTPAGP-VWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVF 71
G+ AG +W A++DYEA G++EL+LRRG V+VLSQD AVSGDEGWW GQ+ R+G+F
Sbjct: 34 GSASAGAGLWAALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAGQVQR-RLGIF 92
Query: 72 PSNYVAPGAPAA-----PAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKA 126
P+NYVAP PAA P+ P + F L+L+E+IG GGFG+VYRA W+G+EVAVKA
Sbjct: 93 PANYVAPCRPAASPAPPPSRPSSPVHVAFERLELKELIGAGGFGQVYRATWQGQEVAVKA 152
Query: 127 ARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVL 186
AR DPE+D A AE V +EARLF L+HPNII LRG CL PHLCLV+E+ARGGAL+R L
Sbjct: 153 ARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRAL 212
Query: 187 AG---------------RRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILIL 231
A RR+PPHVLVNWAVQ+ARGM YLH +A VPI+HRDLKS NIL+L
Sbjct: 213 AAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLL 272
Query: 232 EAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGV 291
E IE+ ++ + LKITDFGLAREWH+TTKMS AGTYAWMAPEVI+ SLFSK SD+WS+GV
Sbjct: 273 EKIEHDDICNKTLKITDFGLAREWHRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGV 332
Query: 292 LLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFG 351
LLWELLTGEVPYR ID LAVAYGVA+NKLTLPIPSTCPEPFA+L++ECW DPH RP F
Sbjct: 333 LLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFA 392
Query: 352 SILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQE 411
IL++L IE + + +MP ESFHS+Q+DWKLEIQ MFD+LRTKEKELRSREEEL RAA +
Sbjct: 393 LILEQLTAIEGAVMTEMPQESFHSMQDDWKLEIQQMFDELRTKEKELRSREEELTRAALQ 452
Query: 412 QRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGG 471
Q+ QEE L+RREQ+LAERE+D++EREL++L+ QL+QEKP+V+KRKG FKRSR LKL++ G
Sbjct: 453 QKSQEELLKRREQQLAEREIDVLERELNILIFQLNQEKPKVKKRKGKFKRSR-LKLKD-G 510
Query: 472 SHISLPSGFEHKITVQASPTLDKRK--GSDGASPPASPSIIPRLRAIRLTPVDCGGSSSG 529
ISLPS F+HKITVQASP LDKR+ S +SPP+SP+++PRLRAI+LT
Sbjct: 511 HRISLPSDFQHKITVQASPNLDKRRSLNSSSSSPPSSPTMMPRLRAIQLT---------- 560
Query: 530 SSSGGSGTWSRGGPPKKEELV----GGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQ 585
S + TW R ++EE KKKG TWGP+S K+R +ER++ L +G+
Sbjct: 561 -SDESNKTWGRNTVFRQEEFEDVKRNFKKKGCTWGPNSIQMKDRTDCKERIRPLSDGNSP 619
Query: 586 WSSSAPNLGKSPKHTPIAPGFASL-NEMEEFAEAEDGGSSVPPSPYSTPS--YLSVPLPA 642
WS+ L K+ K P+A F EE + DG P PS Y+ +PL
Sbjct: 620 WSTI---LIKNQKTMPLASLFVDQPGSCEEPKLSPDGLEHRKPKQIKLPSQAYIDLPLGK 676
Query: 643 E---PSPGARAPWEPTPSAPPARWG-----------HGARRRCDLALLGCATLLGAVGLG 688
+ +P WE SA A R++ + AL GC LL +V LG
Sbjct: 677 DAQRENPAEAESWEEAASANAATVSIEMTPTNSLSRSPQRKKTESALYGCTVLLASVALG 736
Query: 689 ADVAE---ARAAD---GEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLGLAP 742
D+ E A+AA+ +E+++ +G+ F RA + R SPP + L
Sbjct: 737 LDLRELHKAQAAEEPLPKEEKKKREGI-FQRASKSRRSASPPTSLPSTCGEASSPPSLPL 795
Query: 743 SATLVSLSSVSDCNSTRSLLRSDS-DEAAPAAP--------SPPPSPPAPTPTPSPSTNP 793
S+ L LS+ S ST+ LL+ DS D +AP +P P AP P+ P
Sbjct: 796 SSALGILSTPS--FSTKCLLQMDSEDPLVDSAPVTCDSEMLTPDFCPTAPGSGREPALMP 853
Query: 794 LVDLELESFKKDPRQSLTPTHVTAA-CAVSR----GHRRTPSDGALGQRGPPEPAGHGPG 848
+D + + P L T CA S+ HRRT SDG G + G
Sbjct: 854 RLDTDCSVSRNLPSSFLQQTCGNVPYCASSKHRPSHHRRTMSDGNPTPTGATIISATGAS 913
Query: 849 PRDLLDFPRLPDPQALFPARRRPPEF-PGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRT 907
P P P P P E P + +T+ P+ RPA+ R R D + ++ +T
Sbjct: 914 A-----LPLCPSPA---PHSHLPREVSPKKHSTVHIVPQRRPASLRSRSDLPQ--AYPQT 963
Query: 908 LTISPPSRPDTPESPGPPSVQ------------PTLLDMDMEGQNQDSTVPLC 948
PGP Q P+LLD D+EGQ++D TVPLC
Sbjct: 964 AVSQLAQTACVVGRPGPHPTQFLAAKERTKSHVPSLLDADVEGQSRDYTVPLC 1016
>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
sapiens]
Length = 847
Score = 721 bits (1861), Expect = 0.0
Identities = 431/909 (47%), Positives = 522/909 (57%), Gaps = 151/909 (16%)
Query: 17 AGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYV 76
A PVWTA+FDYE +G +EL LR+GDRV+VLS+D A+SGDEGWW GQ+ G+VG+FPSNYV
Sbjct: 42 ANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQV-GGQVGIFPSNYV 100
Query: 77 APGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPA 136
+ G P + F EL+LEE+IG+GGFGKVYR WRGE VAVKAAR DP++D +
Sbjct: 101 SRGGGPPPC-----EVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDIS 155
Query: 137 VTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVL 196
VTAE V QEARLF L HPNIIAL+ CL P+LCLVMEYA GG LSR LAGRRVPPHVL
Sbjct: 156 VTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVL 215
Query: 197 VNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWH 256
VNWAVQ+ARGM+YLH +A VP+IHRDLKS NIL+L+ IE+ ++ LKITDFGLAREWH
Sbjct: 216 VNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWH 275
Query: 257 KTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVA 316
KTT+MSAAGTYAWMAPEVI+ S FSK SDVWSFGVLLWELLTGEVPYR ID LAVAYGVA
Sbjct: 276 KTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVA 335
Query: 317 MNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSL 376
+NKLTLPIPSTCPEPFA+L+ +CW DPH RPDF SIL++LE +E L +MP +SFHS+
Sbjct: 336 VNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSM 395
Query: 377 QEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVER 436
QE WK EIQ +FD+LR KEKEL SREEEL RAA+EQR Q EQLRRRE LA+ E+++ ER
Sbjct: 396 QEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFER 455
Query: 437 ELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRK 496
EL LL+ Q+ +E+P VR+R+G FKRS+ L+ R+GG IS+P F+H+ITVQASP LD+R+
Sbjct: 456 ELTLLLQQVDRERPHVRRRRGTFKRSK-LRARDGGERISMPLDFKHRITVQASPGLDRRR 514
Query: 497 GSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKG 556
P SP+ PR RAI+L P + G + W R P + E+ G+++
Sbjct: 515 NVFEVGPGDSPT-FPRFRAIQLEPAEPGQA-----------WGRQSPRRLEDSSNGERRA 562
Query: 557 -RTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEF 615
WGPSS E G R + + E + S SP +P P + N
Sbjct: 563 CWAWGPSSPKPGEAQNGRRRSR-MDEATWYLDSD----DSSPLGSPSTPPALNGN----- 612
Query: 616 AEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARWGHGARRRCDLAL 675
PP P P P+PAE + P + AL
Sbjct: 613 ----------PPRPSLEPEEPKRPVPAERGSSSGTP-----------------KLIQRAL 645
Query: 676 LGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVG 735
L LL ++GLG D L PP G
Sbjct: 646 LRGTALLASLGLGRD------------------------------LQPPG---------G 666
Query: 736 PGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTNPLV 795
PG S T +PP PAP PT P +PL+
Sbjct: 667 PGRERGESPT-----------------------------TPPTPTPAPCPT-EPPPSPLI 696
Query: 796 DLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPPEPAGH--GPGPRDLL 853
L K P TP + + G R A R EP G P P
Sbjct: 697 CFSL----KTPDSPPTPAPLLLDLGIPVGQR-----SAKSPRREEEPRGGTVSPPPGTSR 747
Query: 854 DFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLTISPP 913
P P R PP L RPRP+ R R+DPW VS G + P
Sbjct: 748 SAPGTPG------TPRSPP--------LGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPS 793
Query: 914 SRPDTPESP 922
+P +P
Sbjct: 794 PQPAPRRAP 802
>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
sapiens]
Length = 859
Score = 280 bits (716), Expect = 5e-75
Identities = 239/748 (31%), Positives = 334/748 (44%), Gaps = 83/748 (11%)
Query: 92 EIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGA 151
E+PF E+ + +G G G V+ + GEEVAVK R E D +
Sbjct: 119 EVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETD-----------IKHLRK 167
Query: 152 LQHPNIIALRGACLNPPHLCLVMEYARGGALSRVL-AGRRVPPHVLVNWAVQVARGMNYL 210
L+HPNII +G C P C++ME+ G L VL AGR V P +LV+W++ +A GMNYL
Sbjct: 168 LKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYL 227
Query: 211 HNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWH-KTTKMSAAGTYAW 269
H IIHRDLKS N+LI D V+KI+DFG ++E K+TKMS AGT AW
Sbjct: 228 HLHK---IIHRDLKSPNMLITY--------DDVVKISDFGTSKELSDKSTKMSFAGTVAW 276
Query: 270 MAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCP 329
MAPEVIR S+ D+WSFGV+LWELLTGE+PY+++D+ A+ +GV N L LP+PS+CP
Sbjct: 277 MAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCP 336
Query: 330 EPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFD 389
+ F LL +CW+ P RP F IL L++ L P E++ Q +W+ E++ F+
Sbjct: 337 DGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVL-STPQETYFKSQAEWREEVKLHFE 395
Query: 390 DLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEK 449
++++ L EEEL+ +E+ +R + ER ++ EL+ LM QL
Sbjct: 396 KIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLY-MELNALMLQLE--- 451
Query: 450 PRVRKRKGNFKRSRLLKLREGGSHISLPS-GFEHKITVQASPTLDKRKGSDGASPPA--- 505
K + +R + L+ R G PS G H T++ + KR SP +
Sbjct: 452 ---LKERELLRREQALERRCPGLLKPHPSRGLLHGNTME--KLIKKRNVPQKLSPHSKRP 506
Query: 506 ----SPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGP 561
+ S++P+L A L+ V G S G SR G + + G G
Sbjct: 507 DILKTESLLPKLDA-ALSGVGLPGCPKAPPSPGR---SRRGKTRHRKASAKGSCGDLPGL 562
Query: 562 SSTLQKERVGGEERLKGLGEGSKQWSSSAPNL-------------GKSPKHTPIAPGFAS 608
+ + GG GLG G W + P L SP A G
Sbjct: 563 RTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRG 622
Query: 609 LNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARW----- 663
A D GS P + PS S P P A EP P P
Sbjct: 623 RGAT---GGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLG 679
Query: 664 -------GHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDG-LFFPRAG 715
G G R L A L A ++ R EE+ +D + +
Sbjct: 680 TGREGTSGRGGSRAGSQHLTPAALLYRA---AVTRSQKRGISSEEEEGEVDSEVELTSSQ 736
Query: 716 RFPRGLSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSD--SDEAAPAA 773
R+P+ L+ + P G +A+ S S + ST + R D SD+
Sbjct: 737 RWPQSLN-MRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQG 795
Query: 774 PSPP--PSPPAPTPTPSPSTNPLVDLEL 799
P P P P P PS+ P+ EL
Sbjct: 796 SEIPLDPPPSEVIPGPEPSSLPIPHQEL 823
>gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo
sapiens]
Length = 966
Score = 260 bits (664), Expect = 5e-69
Identities = 169/473 (35%), Positives = 244/473 (51%), Gaps = 66/473 (13%)
Query: 92 EIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGA 151
E+PF E+ + +G G G V+ +R EEVA+K R E D +
Sbjct: 162 EVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETD-----------IKHLRK 210
Query: 152 LQHPNIIALRGACLNPPHLCLVMEYARGGALSRVL-AGRRVPPHVLVNWAVQVARGMNYL 210
L+HPNIIA +G C P C++MEY G L VL AGR++ P +LV+W+ +A GMNYL
Sbjct: 211 LKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYL 270
Query: 211 HNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWH-KTTKMSAAGTYAW 269
H IIHRDLKS N+L+ +KI+DFG ++E K+TKMS AGT AW
Sbjct: 271 HLHK---IIHRDLKSPNVLVTHT--------DAVKISDFGTSKELSDKSTKMSFAGTVAW 319
Query: 270 MAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCP 329
MAPEVIR S+ D+WSFGV+LWELLTGE+PY+++D+ A+ +GV N L LP+PSTCP
Sbjct: 320 MAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCP 379
Query: 330 EPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFD 389
+ F L+++ W P RP F L L++ L P E++ Q +W+ E++ F+
Sbjct: 380 DGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVL-ATPQETYFKSQAEWREEVKKHFE 438
Query: 390 DLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEK 449
++++ + +EEL+R +E+ +R + ER ++ EL +M QL +
Sbjct: 439 KIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERANNLY-MELSAIMLQLEMRE 497
Query: 450 PRVRKRK--------GNFKR------------SRLLKLREGGSHISLPSGFEHK------ 483
+ KR+ G +KR +L+K R+G H SG + K
Sbjct: 498 KELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMK-RKGVPH---KSGMQTKRPDLLR 553
Query: 484 ----ITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSS 532
T + +PT GS S +S S R P G+S GS S
Sbjct: 554 SEGIPTTEVAPTASPLSGSPKMSTSSSKS------RYRSKPRHRRGNSRGSHS 600
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 225 bits (573), Expect = 2e-58
Identities = 134/343 (39%), Positives = 191/343 (55%), Gaps = 32/343 (9%)
Query: 92 EIPFHELQLEEIIGVGGFGKVYRALW--RGEEVAVKAARLDPEKDPAVTAEQVCQEARLF 149
+I F +LQ E G G FG VYRA W + +EVAVK ++ +EA +
Sbjct: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLL------------KIEKEAEIL 57
Query: 150 GALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRR---VPPHVLVNWAVQVARG 206
L H NII G L PP+ +V EYA G+L + R + ++ WA VA+G
Sbjct: 58 SVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKG 117
Query: 207 MNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGT 266
M+YLH +APV +IHRDLKS N++I AD VLKI DFG +R + TT MS GT
Sbjct: 118 MHYLHMEAPVKVIHRDLKSRNVVIA--------ADGVLKICDFGASRFHNHTTHMSLVGT 169
Query: 267 YAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPS 326
+ WMAPEVI+ S++ D +S+GV+LWE+LT EVP++ ++ L VA+ V L IPS
Sbjct: 170 FPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPS 229
Query: 327 TCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQH 386
+CP FA LL +CW+ D RP F I+ LE + SF + +W+ EI+
Sbjct: 230 SCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEA 289
Query: 387 MFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAER 429
+ L+ E++L +E+EL + +E +L+ EQ+L E+
Sbjct: 290 TLERLKKLERDLSFKEQEL-------KERERRLKMWEQKLTEQ 325
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 225 bits (573), Expect = 2e-58
Identities = 134/343 (39%), Positives = 191/343 (55%), Gaps = 32/343 (9%)
Query: 92 EIPFHELQLEEIIGVGGFGKVYRALW--RGEEVAVKAARLDPEKDPAVTAEQVCQEARLF 149
+I F +LQ E G G FG VYRA W + +EVAVK ++ +EA +
Sbjct: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLL------------KIEKEAEIL 57
Query: 150 GALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRR---VPPHVLVNWAVQVARG 206
L H NII G L PP+ +V EYA G+L + R + ++ WA VA+G
Sbjct: 58 SVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKG 117
Query: 207 MNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGT 266
M+YLH +APV +IHRDLKS N++I AD VLKI DFG +R + TT MS GT
Sbjct: 118 MHYLHMEAPVKVIHRDLKSRNVVIA--------ADGVLKICDFGASRFHNHTTHMSLVGT 169
Query: 267 YAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPS 326
+ WMAPEVI+ S++ D +S+GV+LWE+LT EVP++ ++ L VA+ V L IPS
Sbjct: 170 FPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPS 229
Query: 327 TCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQH 386
+CP FA LL +CW+ D RP F I+ LE + SF + +W+ EI+
Sbjct: 230 SCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEA 289
Query: 387 MFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAER 429
+ L+ E++L +E+EL + +E +L+ EQ+L E+
Sbjct: 290 TLERLKKLERDLSFKEQEL-------KERERRLKMWEQKLTEQ 325
>gi|21735566 mitogen-activated protein kinase kinase kinase 7
isoform D [Homo sapiens]
Length = 491
Score = 184 bits (466), Expect = 4e-46
Identities = 107/278 (38%), Positives = 158/278 (56%), Gaps = 21/278 (7%)
Query: 83 APAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQV 142
AP+ + +EI + E+++EE++G G FG V +A WR ++VA+K + E+ +
Sbjct: 21 APSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIV---- 76
Query: 143 CQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVL----VN 198
E R + HPNI+ L GACLNP +CLVMEYA GG+L VL G P+ ++
Sbjct: 77 --ELRQLSRVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMS 132
Query: 199 WAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKT 258
W +Q ++G+ YLH+ P +IHRDLK N+L++ TVLKI DFG A + +T
Sbjct: 133 WCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAG-------GTVLKICDFGTACDI-QT 184
Query: 259 TKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMN 318
+ G+ AWMAPEV S +S+ DV+S+G++LWE++T P+ EI A A++
Sbjct: 185 HMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVH 244
Query: 319 KLTL-PIPSTCPEPFARLLEECWDPDPHGRPDFGSILK 355
T P+ P+P L+ CW DP RP I+K
Sbjct: 245 NGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVK 282
>gi|21735564 mitogen-activated protein kinase kinase kinase 7
isoform C [Homo sapiens]
Length = 518
Score = 184 bits (466), Expect = 4e-46
Identities = 107/278 (38%), Positives = 158/278 (56%), Gaps = 21/278 (7%)
Query: 83 APAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQV 142
AP+ + +EI + E+++EE++G G FG V +A WR ++VA+K + E+ +
Sbjct: 21 APSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIV---- 76
Query: 143 CQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVL----VN 198
E R + HPNI+ L GACLNP +CLVMEYA GG+L VL G P+ ++
Sbjct: 77 --ELRQLSRVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMS 132
Query: 199 WAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKT 258
W +Q ++G+ YLH+ P +IHRDLK N+L++ TVLKI DFG A + +T
Sbjct: 133 WCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAG-------GTVLKICDFGTACDI-QT 184
Query: 259 TKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMN 318
+ G+ AWMAPEV S +S+ DV+S+G++LWE++T P+ EI A A++
Sbjct: 185 HMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVH 244
Query: 319 KLTL-PIPSTCPEPFARLLEECWDPDPHGRPDFGSILK 355
T P+ P+P L+ CW DP RP I+K
Sbjct: 245 NGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVK 282
>gi|21735562 mitogen-activated protein kinase kinase kinase 7
isoform B [Homo sapiens]
Length = 606
Score = 184 bits (466), Expect = 4e-46
Identities = 107/278 (38%), Positives = 158/278 (56%), Gaps = 21/278 (7%)
Query: 83 APAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQV 142
AP+ + +EI + E+++EE++G G FG V +A WR ++VA+K + E+ +
Sbjct: 21 APSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIV---- 76
Query: 143 CQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVL----VN 198
E R + HPNI+ L GACLNP +CLVMEYA GG+L VL G P+ ++
Sbjct: 77 --ELRQLSRVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMS 132
Query: 199 WAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKT 258
W +Q ++G+ YLH+ P +IHRDLK N+L++ TVLKI DFG A + +T
Sbjct: 133 WCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAG-------GTVLKICDFGTACDI-QT 184
Query: 259 TKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMN 318
+ G+ AWMAPEV S +S+ DV+S+G++LWE++T P+ EI A A++
Sbjct: 185 HMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVH 244
Query: 319 KLTL-PIPSTCPEPFARLLEECWDPDPHGRPDFGSILK 355
T P+ P+P L+ CW DP RP I+K
Sbjct: 245 NGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVK 282
>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
A [Homo sapiens]
Length = 579
Score = 184 bits (466), Expect = 4e-46
Identities = 107/278 (38%), Positives = 158/278 (56%), Gaps = 21/278 (7%)
Query: 83 APAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQV 142
AP+ + +EI + E+++EE++G G FG V +A WR ++VA+K + E+ +
Sbjct: 21 APSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIV---- 76
Query: 143 CQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVL----VN 198
E R + HPNI+ L GACLNP +CLVMEYA GG+L VL G P+ ++
Sbjct: 77 --ELRQLSRVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMS 132
Query: 199 WAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKT 258
W +Q ++G+ YLH+ P +IHRDLK N+L++ TVLKI DFG A + +T
Sbjct: 133 WCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAG-------GTVLKICDFGTACDI-QT 184
Query: 259 TKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMN 318
+ G+ AWMAPEV S +S+ DV+S+G++LWE++T P+ EI A A++
Sbjct: 185 HMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVH 244
Query: 319 KLTL-PIPSTCPEPFARLLEECWDPDPHGRPDFGSILK 355
T P+ P+P L+ CW DP RP I+K
Sbjct: 245 NGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVK 282
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 155 bits (392), Expect = 2e-37
Identities = 99/283 (34%), Positives = 149/283 (52%), Gaps = 21/283 (7%)
Query: 85 AGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQ 144
AGL + E++ EIIG G FGKVY+ R + VA+K R + + + C+
Sbjct: 450 AGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKS-DVDMFCR 508
Query: 145 EARLFGALQHPNIIALRGACLNPP-HLCLVMEYARGGALSRVLAGRR----VPPHVLVNW 199
E + L HP +I GACLN P +V +Y GG+L +L ++ + +++
Sbjct: 509 EVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLII-- 566
Query: 200 AVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAR---EWH 256
AV VA+GM YLHN PIIHRDL S NIL+ E D + DFG +R
Sbjct: 567 AVDVAKGMEYLHN-LTQPIIHRDLNSHNILLYE--------DGHAVVADFGESRFLQSLD 617
Query: 257 KTTKMSAAGTYAWMAPEVI-RLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGV 315
+ G WMAPEV + + ++ +DV+S+ + LWE+LTGE+P+ + A A +
Sbjct: 618 EDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADM 677
Query: 316 AMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLE 358
A + + PI + P+P + LL W+ P GRP+F ++ +LE
Sbjct: 678 AYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLE 720
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 155 bits (392), Expect = 2e-37
Identities = 99/283 (34%), Positives = 149/283 (52%), Gaps = 21/283 (7%)
Query: 85 AGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQ 144
AGL + E++ EIIG G FGKVY+ R + VA+K R + + + C+
Sbjct: 551 AGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKS-DVDMFCR 609
Query: 145 EARLFGALQHPNIIALRGACLNPP-HLCLVMEYARGGALSRVLAGRR----VPPHVLVNW 199
E + L HP +I GACLN P +V +Y GG+L +L ++ + +++
Sbjct: 610 EVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLII-- 667
Query: 200 AVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAR---EWH 256
AV VA+GM YLHN PIIHRDL S NIL+ E D + DFG +R
Sbjct: 668 AVDVAKGMEYLHN-LTQPIIHRDLNSHNILLYE--------DGHAVVADFGESRFLQSLD 718
Query: 257 KTTKMSAAGTYAWMAPEVI-RLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGV 315
+ G WMAPEV + + ++ +DV+S+ + LWE+LTGE+P+ + A A +
Sbjct: 719 EDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADM 778
Query: 316 AMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLE 358
A + + PI + P+P + LL W+ P GRP+F ++ +LE
Sbjct: 779 AYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLE 821
>gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]
Length = 694
Score = 139 bits (351), Expect = 1e-32
Identities = 97/275 (35%), Positives = 131/275 (47%), Gaps = 24/275 (8%)
Query: 97 ELQLEEIIGVGGFGKVYRALWRGEE--VAVKAARLDPEKDPAVTAEQVCQEARLFGALQH 154
+L L E IG G FG+V+ R + VAVK+ R E P + QEAR+ H
Sbjct: 432 DLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCR---ETLPPDLKAKFLQEARILKQYSH 488
Query: 155 PNIIALRGACLNPPHLCLVMEYARGGALSRVLA--GRRVPPHVLVNWAVQVARGMNYLHN 212
PNI+ L G C + +VME +GG L G R+ L+ A GM YL +
Sbjct: 489 PNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLES 548
Query: 213 DAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGT----YA 268
IHRDL + N L+ E VLKI+DFG++RE ++ G
Sbjct: 549 KC---CIHRDLAARNCLVTEK--------NVLKISDFGMSREEADGVYAASGGLRQVPVK 597
Query: 269 WMAPEVIRLSLFSKSSDVWSFGVLLWELLT-GEVPYREIDALAVAYGVAMNKLTLPIPST 327
W APE + +S SDVWSFG+LLWE + G PY + V LP P
Sbjct: 598 WTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGG-RLPCPEL 656
Query: 328 CPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQ 362
CP+ RL+E+CW +P RP F +I + L+ I +
Sbjct: 657 CPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRK 691
>gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
Length = 752
Score = 139 bits (351), Expect = 1e-32
Identities = 97/275 (35%), Positives = 131/275 (47%), Gaps = 24/275 (8%)
Query: 97 ELQLEEIIGVGGFGKVYRALWRGEE--VAVKAARLDPEKDPAVTAEQVCQEARLFGALQH 154
+L L E IG G FG+V+ R + VAVK+ R E P + QEAR+ H
Sbjct: 490 DLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCR---ETLPPDLKAKFLQEARILKQYSH 546
Query: 155 PNIIALRGACLNPPHLCLVMEYARGGALSRVLA--GRRVPPHVLVNWAVQVARGMNYLHN 212
PNI+ L G C + +VME +GG L G R+ L+ A GM YL +
Sbjct: 547 PNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLES 606
Query: 213 DAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGT----YA 268
IHRDL + N L+ E VLKI+DFG++RE ++ G
Sbjct: 607 KC---CIHRDLAARNCLVTEK--------NVLKISDFGMSREEADGVYAASGGLRQVPVK 655
Query: 269 WMAPEVIRLSLFSKSSDVWSFGVLLWELLT-GEVPYREIDALAVAYGVAMNKLTLPIPST 327
W APE + +S SDVWSFG+LLWE + G PY + V LP P
Sbjct: 656 WTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGG-RLPCPEL 714
Query: 328 CPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQ 362
CP+ RL+E+CW +P RP F +I + L+ I +
Sbjct: 715 CPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRK 749
>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
Length = 764
Score = 139 bits (351), Expect = 1e-32
Identities = 97/275 (35%), Positives = 131/275 (47%), Gaps = 24/275 (8%)
Query: 97 ELQLEEIIGVGGFGKVYRALWRGEE--VAVKAARLDPEKDPAVTAEQVCQEARLFGALQH 154
+L L E IG G FG+V+ R + VAVK+ R E P + QEAR+ H
Sbjct: 502 DLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCR---ETLPPDLKAKFLQEARILKQYSH 558
Query: 155 PNIIALRGACLNPPHLCLVMEYARGGALSRVLA--GRRVPPHVLVNWAVQVARGMNYLHN 212
PNI+ L G C + +VME +GG L G R+ L+ A GM YL +
Sbjct: 559 PNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLES 618
Query: 213 DAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGT----YA 268
IHRDL + N L+ E VLKI+DFG++RE ++ G
Sbjct: 619 KC---CIHRDLAARNCLVTEK--------NVLKISDFGMSREEADGVYAASGGLRQVPVK 667
Query: 269 WMAPEVIRLSLFSKSSDVWSFGVLLWELLT-GEVPYREIDALAVAYGVAMNKLTLPIPST 327
W APE + +S SDVWSFG+LLWE + G PY + V LP P
Sbjct: 668 WTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGG-RLPCPEL 726
Query: 328 CPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQ 362
CP+ RL+E+CW +P RP F +I + L+ I +
Sbjct: 727 CPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRK 761
>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
Length = 822
Score = 139 bits (351), Expect = 1e-32
Identities = 97/275 (35%), Positives = 131/275 (47%), Gaps = 24/275 (8%)
Query: 97 ELQLEEIIGVGGFGKVYRALWRGEE--VAVKAARLDPEKDPAVTAEQVCQEARLFGALQH 154
+L L E IG G FG+V+ R + VAVK+ R E P + QEAR+ H
Sbjct: 560 DLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCR---ETLPPDLKAKFLQEARILKQYSH 616
Query: 155 PNIIALRGACLNPPHLCLVMEYARGGALSRVLA--GRRVPPHVLVNWAVQVARGMNYLHN 212
PNI+ L G C + +VME +GG L G R+ L+ A GM YL +
Sbjct: 617 PNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLES 676
Query: 213 DAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGT----YA 268
IHRDL + N L+ E VLKI+DFG++RE ++ G
Sbjct: 677 KC---CIHRDLAARNCLVTEK--------NVLKISDFGMSREEADGVYAASGGLRQVPVK 725
Query: 269 WMAPEVIRLSLFSKSSDVWSFGVLLWELLT-GEVPYREIDALAVAYGVAMNKLTLPIPST 327
W APE + +S SDVWSFG+LLWE + G PY + V LP P
Sbjct: 726 WTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGG-RLPCPEL 784
Query: 328 CPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQ 362
CP+ RL+E+CW +P RP F +I + L+ I +
Sbjct: 785 CPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRK 819
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 139 bits (351), Expect = 1e-32
Identities = 97/278 (34%), Positives = 143/278 (51%), Gaps = 28/278 (10%)
Query: 92 EIPFHELQLEEIIGVGGFGKVYRALWRGEE-VAVKAARLDPEKDPAVTAEQVCQEARLFG 150
EI + +QL + +G G FG+V+ LW VAVK K ++ +EA++
Sbjct: 228 EIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTL-----KPGSMDPNDFLREAQIMK 282
Query: 151 ALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVL---AGRRVPPHVLVNWAVQVARGM 207
L+HP +I L C + ++ E R G+L L G ++ V+ A QVA GM
Sbjct: 283 NLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGM 342
Query: 208 NYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTY 267
YL + IHRDL + N+L+ E HN + K+ DFGLAR + + +
Sbjct: 343 AYLESRN---YIHRDLAARNVLVGE----HN----IYKVADFGLARVFKVDNEDIYESRH 391
Query: 268 A------WMAPEVIRLSLFSKSSDVWSFGVLLWELLT-GEVPYREIDALAVAYGVAMNKL 320
W APE IR + FS SDVWSFG+LL+E++T G++PY + V +A N
Sbjct: 392 EIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQN-Y 450
Query: 321 TLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLE 358
LP PS CP+ F ++ ECW+ +P RP F ++ +LE
Sbjct: 451 RLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLE 488
Score = 42.4 bits (98), Expect = 0.002
Identities = 26/68 (38%), Positives = 35/68 (51%), Gaps = 13/68 (19%)
Query: 18 GPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGR--------VG 69
G + A+FDY+A E+L+ R GD++QVL + EGWW + R G
Sbjct: 44 GHYFVALFDYQARTAEDLSFRAGDKLQVLD-----TLHEGWWFARHLEKRRDGSSQQLQG 98
Query: 70 VFPSNYVA 77
PSNYVA
Sbjct: 99 YIPSNYVA 106
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 133 bits (335), Expect = 7e-31
Identities = 89/275 (32%), Positives = 134/275 (48%), Gaps = 22/275 (8%)
Query: 97 ELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPN 156
++ ++ +G G +G+VY +W+ + V L K+ + E+ +EA + ++HPN
Sbjct: 241 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTL---KEDTMEVEEFLKEAAVMKEIKHPN 297
Query: 157 IIALRGACLNPPHLCLVMEYARGGALSRVLAG---RRVPPHVLVNWAVQVARGMNYLHND 213
++ L G C P ++ E+ G L L + V VL+ A Q++ M YL
Sbjct: 298 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 357
Query: 214 APVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGT---YAWM 270
IHRDL + N L+ E NH ++K+ DFGL+R T + AG W
Sbjct: 358 N---FIHRDLAARNCLVGE---NH-----LVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 406
Query: 271 APEVIRLSLFSKSSDVWSFGVLLWELLT-GEVPYREIDALAVAYGVAMNKLTLPIPSTCP 329
APE + + FS SDVW+FGVLLWE+ T G PY ID L+ Y + + P CP
Sbjct: 407 APESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYELLEKDYRMERPEGCP 465
Query: 330 EPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSA 364
E L+ CW +P RP F I + E + Q +
Sbjct: 466 EKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES 500
Score = 37.0 bits (84), Expect = 0.088
Identities = 18/59 (30%), Positives = 36/59 (61%), Gaps = 5/59 (8%)
Query: 20 VWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAP 78
++ A++D+ A+GD L++ +G++++VL + + W Q +G+ G PSNY+ P
Sbjct: 65 LFVALYDFVASGDNTLSITKGEKLRVL----GYNHNGEWCEAQTKNGQ-GWVPSNYITP 118
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 133 bits (335), Expect = 7e-31
Identities = 89/275 (32%), Positives = 134/275 (48%), Gaps = 22/275 (8%)
Query: 97 ELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPN 156
++ ++ +G G +G+VY +W+ + V L K+ + E+ +EA + ++HPN
Sbjct: 260 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTL---KEDTMEVEEFLKEAAVMKEIKHPN 316
Query: 157 IIALRGACLNPPHLCLVMEYARGGALSRVLAG---RRVPPHVLVNWAVQVARGMNYLHND 213
++ L G C P ++ E+ G L L + V VL+ A Q++ M YL
Sbjct: 317 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 376
Query: 214 APVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGT---YAWM 270
IHRDL + N L+ E NH ++K+ DFGL+R T + AG W
Sbjct: 377 N---FIHRDLAARNCLVGE---NH-----LVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 425
Query: 271 APEVIRLSLFSKSSDVWSFGVLLWELLT-GEVPYREIDALAVAYGVAMNKLTLPIPSTCP 329
APE + + FS SDVW+FGVLLWE+ T G PY ID L+ Y + + P CP
Sbjct: 426 APESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYELLEKDYRMERPEGCP 484
Query: 330 EPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSA 364
E L+ CW +P RP F I + E + Q +
Sbjct: 485 EKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES 519
Score = 37.0 bits (84), Expect = 0.088
Identities = 18/59 (30%), Positives = 36/59 (61%), Gaps = 5/59 (8%)
Query: 20 VWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAP 78
++ A++D+ A+GD L++ +G++++VL + + W Q +G+ G PSNY+ P
Sbjct: 84 LFVALYDFVASGDNTLSITKGEKLRVL----GYNHNGEWCEAQTKNGQ-GWVPSNYITP 137
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 133 bits (335), Expect = 7e-31
Identities = 90/276 (32%), Positives = 132/276 (47%), Gaps = 24/276 (8%)
Query: 97 ELQLEEIIGVGGFGKVYRALWRGEE-VAVKAARLDPEKDPAVTAEQVCQEARLFGALQHP 155
EL + IG G FG V+ W ++ VA+K R + A++ E +EA + L HP
Sbjct: 362 ELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIR-----EGAMSEEDFIEEAEVMMKLSHP 416
Query: 156 NIIALRGACLNPPHLCLVMEYARGGALSRVLAGRR--VPPHVLVNWAVQVARGMNYLHND 213
++ L G CL +CLV E+ G LS L +R L+ + V GM YL
Sbjct: 417 KLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEA 476
Query: 214 APVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGT---YAWM 270
+IHRDL + N L+ E + V+K++DFG+ R S+ GT W
Sbjct: 477 C---VIHRDLAARNCLVGE--------NQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWA 525
Query: 271 APEVIRLSLFSKSSDVWSFGVLLWELLT-GEVPYREIDALAVAYGVAMNKLTLPIPSTCP 329
+PEV S +S SDVWSFGVL+WE+ + G++PY V ++ L P
Sbjct: 526 SPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTG-FRLYKPRLAS 584
Query: 330 EPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSAL 365
+++ CW P RP F +L++L I +S L
Sbjct: 585 THVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESGL 620
Score = 37.7 bits (86), Expect = 0.052
Identities = 21/66 (31%), Positives = 32/66 (48%), Gaps = 5/66 (7%)
Query: 16 PAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNY 75
P V A++DY+ +EL LRR + +L S + WW Q +G G PS+Y
Sbjct: 171 PEETVVIALYDYQTNDPQELALRRNEEYCLLD-----SSEIHWWRVQDRNGHEGYVPSSY 225
Query: 76 VAPGAP 81
+ +P
Sbjct: 226 LVEKSP 231
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 132 bits (333), Expect = 1e-30
Identities = 93/264 (35%), Positives = 132/264 (50%), Gaps = 24/264 (9%)
Query: 98 LQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNI 157
L L IG G FG V + + G++VAVK + D VTA+ E + +QH N+
Sbjct: 194 LTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCD------VTAQAFLDETAVMTKMQHENL 247
Query: 158 IALRGACLNPPHLCLVMEYARGGALSRVLAGRR---VPPHVLVNWAVQVARGMNYLHNDA 214
+ L G L+ L +VME+ G L L R V L+ +++ VA GM YL +
Sbjct: 248 VRLLGVILHQG-LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKK 306
Query: 215 PVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEV 274
++HRDL + NIL+ E D V K++DFGLA+ K S W APE
Sbjct: 307 ---LVHRDLAARNILVSE--------DLVAKVSDFGLAKAERKGLDSSRLPV-KWTAPEA 354
Query: 275 IRLSLFSKSSDVWSFGVLLWELLT-GEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFA 333
++ F+ SDVWSFGVLLWE+ + G PY ++ V+ V P P CP P
Sbjct: 355 LKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEP-PEGCPGPVH 413
Query: 334 RLLEECWDPDPHGRPDFGSILKRL 357
L+ CW+ +P RP F + ++L
Sbjct: 414 VLMSSCWEAEPARRPPFRKLAEKL 437
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 132 bits (333), Expect = 1e-30
Identities = 93/264 (35%), Positives = 132/264 (50%), Gaps = 24/264 (9%)
Query: 98 LQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNI 157
L L IG G FG V + + G++VAVK + D VTA+ E + +QH N+
Sbjct: 236 LTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCD------VTAQAFLDETAVMTKMQHENL 289
Query: 158 IALRGACLNPPHLCLVMEYARGGALSRVLAGRR---VPPHVLVNWAVQVARGMNYLHNDA 214
+ L G L+ L +VME+ G L L R V L+ +++ VA GM YL +
Sbjct: 290 VRLLGVILHQG-LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKK 348
Query: 215 PVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEV 274
++HRDL + NIL+ E D V K++DFGLA+ K S W APE
Sbjct: 349 ---LVHRDLAARNILVSE--------DLVAKVSDFGLAKAERKGLDSSRLPV-KWTAPEA 396
Query: 275 IRLSLFSKSSDVWSFGVLLWELLT-GEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFA 333
++ F+ SDVWSFGVLLWE+ + G PY ++ V+ V P P CP P
Sbjct: 397 LKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEP-PEGCPGPVH 455
Query: 334 RLLEECWDPDPHGRPDFGSILKRL 357
L+ CW+ +P RP F + ++L
Sbjct: 456 VLMSSCWEAEPARRPPFRKLAEKL 479
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 132 bits (333), Expect = 1e-30
Identities = 93/264 (35%), Positives = 132/264 (50%), Gaps = 24/264 (9%)
Query: 98 LQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNI 157
L L IG G FG V + + G++VAVK + D VTA+ E + +QH N+
Sbjct: 235 LTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCD------VTAQAFLDETAVMTKMQHENL 288
Query: 158 IALRGACLNPPHLCLVMEYARGGALSRVLAGRR---VPPHVLVNWAVQVARGMNYLHNDA 214
+ L G L+ L +VME+ G L L R V L+ +++ VA GM YL +
Sbjct: 289 VRLLGVILHQG-LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKK 347
Query: 215 PVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEV 274
++HRDL + NIL+ E D V K++DFGLA+ K S W APE
Sbjct: 348 ---LVHRDLAARNILVSE--------DLVAKVSDFGLAKAERKGLDSSRLPV-KWTAPEA 395
Query: 275 IRLSLFSKSSDVWSFGVLLWELLT-GEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFA 333
++ F+ SDVWSFGVLLWE+ + G PY ++ V+ V P P CP P
Sbjct: 396 LKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEP-PEGCPGPVH 454
Query: 334 RLLEECWDPDPHGRPDFGSILKRL 357
L+ CW+ +P RP F + ++L
Sbjct: 455 VLMSSCWEAEPARRPPFRKLAEKL 478
>gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo
sapiens]
Length = 1328
Score = 132 bits (333), Expect = 1e-30
Identities = 86/267 (32%), Positives = 135/267 (50%), Gaps = 24/267 (8%)
Query: 102 EIIGVGGFGKVYRALW-RGEEVAVKAARLDPEKDPAVTAE--QVCQEARLFGALQHPNII 158
EI+G G +G VY L +G+ +AVK LD A E ++ +E L AL+H NI+
Sbjct: 1065 EILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIV 1124
Query: 159 ALRGACLNPPHLCLVMEYARGGALSRVLAG-RRVPPHVLVNWAVQVARGMNYLHNDAPVP 217
A G CL + + ME+ GG++S ++ +P V + Q+ +G+ YLH +
Sbjct: 1125 AYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENC--- 1181
Query: 218 IIHRDLKSINILILEAIENHNLADTVLKITDFGLARE--W------HKTTKMSAAGTYAW 269
++HRD+K N++++ ++K+ DFG AR W H S GT W
Sbjct: 1182 VVHRDIKGNNVMLMPT--------GIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYW 1233
Query: 270 MAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNK-LTLPIPSTC 328
MAPEVI S + + SD+WS G ++E+ TG+ P +D +A + + ++ L P+P
Sbjct: 1234 MAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHF 1293
Query: 329 PEPFARLLEECWDPDPHGRPDFGSILK 355
E A + C D H RP +LK
Sbjct: 1294 SENAADFVRMCLTRDQHERPSALQLLK 1320
>gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo
sapiens]
Length = 510
Score = 132 bits (333), Expect = 1e-30
Identities = 86/267 (32%), Positives = 135/267 (50%), Gaps = 24/267 (8%)
Query: 102 EIIGVGGFGKVYRALW-RGEEVAVKAARLDPEKDPAVTAE--QVCQEARLFGALQHPNII 158
EI+G G +G VY L +G+ +AVK LD A E ++ +E L AL+H NI+
Sbjct: 247 EILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIV 306
Query: 159 ALRGACLNPPHLCLVMEYARGGALSRVLAG-RRVPPHVLVNWAVQVARGMNYLHNDAPVP 217
A G CL + + ME+ GG++S ++ +P V + Q+ +G+ YLH +
Sbjct: 307 AYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENC--- 363
Query: 218 IIHRDLKSINILILEAIENHNLADTVLKITDFGLARE--W------HKTTKMSAAGTYAW 269
++HRD+K N++++ ++K+ DFG AR W H S GT W
Sbjct: 364 VVHRDIKGNNVMLMPT--------GIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYW 415
Query: 270 MAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNK-LTLPIPSTC 328
MAPEVI S + + SD+WS G ++E+ TG+ P +D +A + + ++ L P+P
Sbjct: 416 MAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHF 475
Query: 329 PEPFARLLEECWDPDPHGRPDFGSILK 355
E A + C D H RP +LK
Sbjct: 476 SENAADFVRMCLTRDQHERPSALQLLK 502
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 132 bits (331), Expect = 2e-30
Identities = 121/374 (32%), Positives = 173/374 (46%), Gaps = 66/374 (17%)
Query: 46 LSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAP--AAPAGLQLPQ----EIPFHELQ 99
L + VS D + + SG + V PS + G P A + +LP+ E+P L
Sbjct: 332 LRRQVTVSADS---SASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV 388
Query: 100 LEEIIGVGGFGKVYRALWRG---------EEVAVKAARLDP-EKDPAVTAEQVCQEARLF 149
L + +G G FG+V A G +VAVK + D EKD + ++ + ++
Sbjct: 389 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEM-EMMKMI 447
Query: 150 GALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVP----------------- 192
G +H NII L GAC L +++EYA G L L RR P
Sbjct: 448 G--KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLS 505
Query: 193 PHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLA 252
LV+ A QVARGM YL A IHRDL + N+L+ E D V+KI DFGLA
Sbjct: 506 SKDLVSCAYQVARGMEYL---ASKKCIHRDLAARNVLVTE--------DNVMKIADFGLA 554
Query: 253 REWH------KTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLT-GEVPYRE 305
R+ H KTT + WMAPE + +++ SDVWSFGVLLWE+ T G PY
Sbjct: 555 RDIHHIDYYKKTT--NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG 612
Query: 306 IDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVI----- 360
+ + + + + PS C ++ +CW P RP F +++ L+ I
Sbjct: 613 V-PVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTS 671
Query: 361 -EQSALFQMPLESF 373
++ MPL+ +
Sbjct: 672 NQEYLDLSMPLDQY 685
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 132 bits (331), Expect = 2e-30
Identities = 121/374 (32%), Positives = 173/374 (46%), Gaps = 66/374 (17%)
Query: 46 LSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAP--AAPAGLQLPQ----EIPFHELQ 99
L + VS D + + SG + V PS + G P A + +LP+ E+P L
Sbjct: 334 LRRQVTVSADS---SASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV 390
Query: 100 LEEIIGVGGFGKVYRALWRG---------EEVAVKAARLDP-EKDPAVTAEQVCQEARLF 149
L + +G G FG+V A G +VAVK + D EKD + ++ + ++
Sbjct: 391 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEM-EMMKMI 449
Query: 150 GALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVP----------------- 192
G +H NII L GAC L +++EYA G L L RR P
Sbjct: 450 G--KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLS 507
Query: 193 PHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLA 252
LV+ A QVARGM YL A IHRDL + N+L+ E D V+KI DFGLA
Sbjct: 508 SKDLVSCAYQVARGMEYL---ASKKCIHRDLAARNVLVTE--------DNVMKIADFGLA 556
Query: 253 REWH------KTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLT-GEVPYRE 305
R+ H KTT + WMAPE + +++ SDVWSFGVLLWE+ T G PY
Sbjct: 557 RDIHHIDYYKKTT--NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG 614
Query: 306 IDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVI----- 360
+ + + + + PS C ++ +CW P RP F +++ L+ I
Sbjct: 615 V-PVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTS 673
Query: 361 -EQSALFQMPLESF 373
++ MPL+ +
Sbjct: 674 NQEYLDLSMPLDQY 687
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 132 bits (331), Expect = 2e-30
Identities = 121/374 (32%), Positives = 173/374 (46%), Gaps = 66/374 (17%)
Query: 46 LSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAP--AAPAGLQLPQ----EIPFHELQ 99
L + VS D + + SG + V PS + G P A + +LP+ E+P L
Sbjct: 421 LRRQVTVSADS---SASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV 477
Query: 100 LEEIIGVGGFGKVYRALWRG---------EEVAVKAARLDP-EKDPAVTAEQVCQEARLF 149
L + +G G FG+V A G +VAVK + D EKD + ++ + ++
Sbjct: 478 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEM-EMMKMI 536
Query: 150 GALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVP----------------- 192
G +H NII L GAC L +++EYA G L L RR P
Sbjct: 537 G--KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLS 594
Query: 193 PHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLA 252
LV+ A QVARGM YL A IHRDL + N+L+ E D V+KI DFGLA
Sbjct: 595 SKDLVSCAYQVARGMEYL---ASKKCIHRDLAARNVLVTE--------DNVMKIADFGLA 643
Query: 253 REWH------KTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLT-GEVPYRE 305
R+ H KTT + WMAPE + +++ SDVWSFGVLLWE+ T G PY
Sbjct: 644 RDIHHIDYYKKTT--NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG 701
Query: 306 IDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVI----- 360
+ + + + + PS C ++ +CW P RP F +++ L+ I
Sbjct: 702 V-PVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTS 760
Query: 361 -EQSALFQMPLESF 373
++ MPL+ +
Sbjct: 761 NQEYLDLSMPLDQY 774
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.134 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,493,018
Number of Sequences: 37866
Number of extensions: 3064485
Number of successful extensions: 42274
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 934
Number of HSP's successfully gapped in prelim test: 1650
Number of HSP's that attempted gapping in prelim test: 21031
Number of HSP's gapped (non-prelim): 14385
length of query: 954
length of database: 18,247,518
effective HSP length: 112
effective length of query: 842
effective length of database: 14,006,526
effective search space: 11793494892
effective search space used: 11793494892
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.