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Search of human proteins with 21536468
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo
sapiens]
(885 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens] 1832 0.0
gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens] 1824 0.0
gi|27597078 TYRO3 protein tyrosine kinase [Homo sapiens] 677 0.0
gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens] 652 0.0
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 240 4e-63
gi|42741655 met proto-oncogene isoform b precursor [Homo sapiens] 234 3e-61
gi|188595716 met proto-oncogene isoform a precursor [Homo sapiens] 234 3e-61
gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 229 7e-60
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens] 229 7e-60
gi|153946393 macrophage stimulating 1 receptor precursor [Homo s... 222 1e-57
gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens] 220 4e-57
gi|29029632 anaplastic lymphoma kinase [Homo sapiens] 218 2e-56
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 216 1e-55
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 216 1e-55
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap... 215 2e-55
gi|31657140 insulin receptor-related receptor precursor [Homo sa... 214 2e-55
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens] 213 6e-55
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens] 213 6e-55
gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precurs... 213 8e-55
gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precurs... 213 8e-55
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 212 1e-54
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 212 1e-54
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 212 1e-54
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 212 1e-54
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 212 1e-54
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 211 2e-54
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 211 2e-54
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 211 2e-54
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 211 2e-54
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 211 2e-54
>gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]
Length = 885
Score = 1832 bits (4745), Expect = 0.0
Identities = 885/885 (100%), Positives = 885/885 (100%)
Query: 1 MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV 60
MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV
Sbjct: 1 MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV 60
Query: 61 QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF 120
QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF
Sbjct: 61 QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF 120
Query: 121 LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL 180
LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL
Sbjct: 121 LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL 180
Query: 181 ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE 240
ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE
Sbjct: 181 ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE 240
Query: 241 LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH 300
LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH
Sbjct: 241 LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH 300
Query: 301 PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL 360
PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL
Sbjct: 301 PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL 360
Query: 361 QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLP 420
QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLP
Sbjct: 361 QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLP 420
Query: 421 VPLEAWRPVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTV 480
VPLEAWRPVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTV
Sbjct: 421 VPLEAWRPVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTV 480
Query: 481 ERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGA 540
ERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGA
Sbjct: 481 ERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGA 540
Query: 541 VMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSE 600
VMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSE
Sbjct: 541 VMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSE 600
Query: 601 RESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFI 660
RESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFI
Sbjct: 601 RESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFI 660
Query: 661 HRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSK 720
HRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSK
Sbjct: 661 HRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSK 720
Query: 721 SDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELN 780
SDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELN
Sbjct: 721 SDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELN 780
Query: 781 PQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPK 840
PQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPK
Sbjct: 781 PQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPK 840
Query: 841 DSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA 885
DSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
Sbjct: 841 DSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA 885
>gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]
Length = 894
Score = 1824 bits (4725), Expect = 0.0
Identities = 885/894 (98%), Positives = 885/894 (98%), Gaps = 9/894 (1%)
Query: 1 MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV 60
MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV
Sbjct: 1 MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV 60
Query: 61 QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF 120
QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF
Sbjct: 61 QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF 120
Query: 121 LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL 180
LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL
Sbjct: 121 LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL 180
Query: 181 ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE 240
ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE
Sbjct: 181 ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE 240
Query: 241 LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH 300
LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH
Sbjct: 241 LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH 300
Query: 301 PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL 360
PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL
Sbjct: 301 PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL 360
Query: 361 QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLP 420
QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLP
Sbjct: 361 QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLP 420
Query: 421 VPLEAWRP---------VKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETR 471
VPLEAWRP VKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETR
Sbjct: 421 VPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETR 480
Query: 472 YGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGK 531
YGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGK
Sbjct: 481 YGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGK 540
Query: 532 TLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL 591
TLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL
Sbjct: 541 TLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL 600
Query: 592 IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM 651
IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM
Sbjct: 601 IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM 660
Query: 652 EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES 711
EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES
Sbjct: 661 EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES 720
Query: 712 LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYA 771
LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYA
Sbjct: 721 LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYA 780
Query: 772 LMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGA 831
LMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGA
Sbjct: 781 LMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGA 840
Query: 832 DPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA 885
DPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
Sbjct: 841 DPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA 894
>gi|27597078 TYRO3 protein tyrosine kinase [Homo sapiens]
Length = 890
Score = 677 bits (1746), Expect = 0.0
Identities = 379/874 (43%), Positives = 522/874 (59%), Gaps = 59/874 (6%)
Query: 6 PRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPP 65
PR+G L L A + + A +G P +T ++G L C ++ E P
Sbjct: 21 PRLG-------LLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGM-EEP 72
Query: 66 EVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQT 125
++ W++DG +++ D Q +P+ E WI L + S++ SD G+Y C V G +T
Sbjct: 73 DIQWVKDGAVVQNLD--QLYIPVSEQH---WI--GFLSLKSVERSDAGRYWCQVEDGGET 125
Query: 126 FVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPG 185
+SQP ++ +EG+P+F EP+D V N PF LSC+A GPPEPV ++W + + G
Sbjct: 126 EISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIG---G 182
Query: 186 HGPQRS-LHVPGLNKTSSFSCEAHNAKGVTTSRTATITV--LPQQPRNLHLVSRQPTELE 242
P S L+V G+ +++ FSCEAHN KG+ +SRTAT+ + LP P N+ + +
Sbjct: 183 PAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNAS 242
Query: 243 VAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPH 302
VAW PG G L CT+Q + G E L VPP L L P
Sbjct: 243 VAWMPGADGRALLQSCTVQVTQAPGGW-----------EVLAVVVPVPPFTCLLRDLVPA 291
Query: 303 TPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQE--PRAPL 360
T Y +RV C ++ GPS + W+P +T P P+N+ A R S + W+E P APL
Sbjct: 292 TNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPL 351
Query: 361 QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLE-----LQGDGSVSNLTVCVAAYTAAGDG 415
+G L Y+L++ + D G + E+T+E L G +L V V A G G
Sbjct: 352 EGPLGPYKLSW--------VQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCG 403
Query: 416 PWSLPVPLEAWRPVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEV 475
PWS P+ + + + P W V+LG + A LAL L+ +R+KETR+G+
Sbjct: 404 PWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQA 463
Query: 476 FEPTVERGELVVRYRVRKSYSRRTTE---ATLNSLGISEELKEKLRDVMVDRHKVALGKT 532
F+ + RGE V +R +S++R E ATL+SLGIS+ELKEKL DV++ + LG+
Sbjct: 464 FDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRM 523
Query: 533 LGEGEFGAVMEGQLNQDD-SILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL 591
LG+GEFG+V E QL Q+D S +KVAVK +K I S++E+FL EA CMKEFDHP+V +L
Sbjct: 524 LGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKL 583
Query: 592 IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM 651
+GV + + P P+VILPFMKHGDLH+FLL SR+G+ P LP Q L++FM DIA GM
Sbjct: 584 VGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGM 643
Query: 652 EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES 711
EYLS++ FIHRDLAARNCML E+M+VCVADFGLS+KIY+GDYYRQG +K+PVKW+A+ES
Sbjct: 644 EYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALES 703
Query: 712 LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYA 771
LAD +YT +SDVW+FGVTMWEI TRGQTPY G+EN+EIY+YL GNRLKQP +C++ +Y
Sbjct: 704 LADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYD 763
Query: 772 LMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGA 831
LM +CW +P+ RPSFT LR +LEN L L + LY+N++ E P A G
Sbjct: 764 LMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERA----EEPTAGGSL 819
Query: 832 DPPTQPDPKDSC---SCLTAAEVHPAG-RYVLCP 861
+ P + P S + A P+ RY+L P
Sbjct: 820 ELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTP 853
>gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens]
Length = 999
Score = 652 bits (1683), Expect = 0.0
Identities = 383/903 (42%), Positives = 533/903 (59%), Gaps = 71/903 (7%)
Query: 27 PRGTQAEESP-----FVGNPGNITGARGLTGTLRCQLQVQG--EPPEVHWLRDGQILELA 79
P+ T E P F G+I + C + V + + W +DG+ L A
Sbjct: 81 PQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGA 140
Query: 80 DSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLP 139
TQ + + +++ ITS+Q SD G Y C + + ++ VS P Y+ ++GLP
Sbjct: 141 HHAITQF---YPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLP 197
Query: 140 YFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNK 199
+F ++PE V NT FNL+CQA GPPEPV++ W+Q++ + P P L VPGL +
Sbjct: 198 HFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPS-VLTVPGLTE 256
Query: 200 TSSFSCEAHNAKGVTTSRTATITV--LPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTH 257
+ FSCEAHN KG+T S+ I + +P P + + + + ++W PG G P +
Sbjct: 257 MAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRN 316
Query: 258 CTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGP 317
C++Q ++ +P + S PH ++ L Y I V+C + G
Sbjct: 317 CSIQ---------VKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGW 367
Query: 318 SSWTHWLPVETPEGVPLGPPENISATRNGSQ--AFVHWQEPRAPLQ-GTLLGYRLAYQGQ 374
S+ + W+ T EG P P N++ N S + W +P Q G L+GYR+++ Q
Sbjct: 368 SAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQ 427
Query: 375 D---TPEVLMDIGL---RQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPV----PLE 424
+ E+L ++G R +++++ + TV +AA T G GP+S PV P
Sbjct: 428 SAGISKELLEEVGQNGSRARISVQVHN----ATCTVRIAAVTRGGVGPFSDPVKIFIPAH 483
Query: 425 AWRPVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFL---VHRRKKETRYGEVFEPTVE 481
W STPA +++ ++ L L++ + +R +ET++G F T E
Sbjct: 484 GWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAF--TEE 541
Query: 482 RGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAV 541
ELVV Y +KS+ RR E TL+SLG+SEEL+ KL DV++DR+ + LGK LGEGEFG+V
Sbjct: 542 DSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSV 601
Query: 542 MEGQLNQDDSI-LKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSE 600
MEG L Q+D LKVAVKTMK+ ++ E+E+FLSEA CMK+F HPNV+RL+GVC + S
Sbjct: 602 MEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSS 661
Query: 601 RESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFI 660
+ P P+VILPFMK+GDLH++LLYSRL P ++P Q L+KFM DIA GMEYLS + F+
Sbjct: 662 -QGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFL 720
Query: 661 HRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSK 720
HRDLAARNCML ++M+VCVADFGLSKKIY+GDYYRQGRIAKMPVKWIAIESLADRVYTSK
Sbjct: 721 HRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSK 780
Query: 721 SDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELN 780
SDVW+FGVTMWEIATRG TPYPGV+N E+YDYL G+RLKQP DCLD LY +M CW +
Sbjct: 781 SDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTD 840
Query: 781 PQDRPSFTELREDLENTLKALPPAQEPDEILYVN---MDEGGGYPEPPGAAGGADPPTQP 837
P DRP+F+ LR LE L++LP + +++YVN ++ G + A D P
Sbjct: 841 PLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLA-PLDLNIDP 899
Query: 838 D-------PKDSCSCLTAAEVHPA----GRYVLCP--------STTPSPAQPADRGSPAA 878
D P+ + S +T AEVH + GRY+L ++ PS A A++ S
Sbjct: 900 DSIIASCTPRAAISVVT-AEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNS-VL 957
Query: 879 PGQ 881
PG+
Sbjct: 958 PGE 960
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 240 bits (613), Expect = 4e-63
Identities = 168/532 (31%), Positives = 269/532 (50%), Gaps = 78/532 (14%)
Query: 296 LGSLHPHTPYHI----------RVACTSSQGPSSWTHWLPVETPEGVPLGP------PEN 339
+ +L P T Y I ++ C++S + T +P E + +P GP PEN
Sbjct: 790 ISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFART--MPAEGADDIP-GPVTWEPRPEN 846
Query: 340 ISATRNGSQAFVHWQEPRAPLQGTLLGYRLAY--QGQDTPEVLMDIGLRQEVTLELQGDG 397
F+ W EP P G +L Y + Y Q +D E + R+ +L
Sbjct: 847 --------SIFLKWPEPENP-NGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLN 897
Query: 398 SVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPVKEPSTPAFSWPWWYVLLGAVVAAACV-- 455
N T + A + +G+G W+ PV + + ++++ VA +
Sbjct: 898 P-GNYTARIQATSLSGNGSWTDPVFFYVQAKTGYEN-------FIHLIIALPVAVLLIVG 949
Query: 456 -LILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELK 514
L++ L++ HR++ +R G V+ V Y + + +E +
Sbjct: 950 GLVIMLYVFHRKRNNSRLGNG----------VLYASVNPEYFSAA------DVYVPDEWE 993
Query: 515 EKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLN---QDDSILKVAVKTMKIAICTRSELE 571
V R K+ + + LG+G FG V EG +D+ +VA+KT+ A R +E
Sbjct: 994 -------VAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIE 1046
Query: 572 DFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFL--LYSRLG 629
FL+EA MKEF+ +V+RL+GV QG +VI+ M GDL S+L L +
Sbjct: 1047 -FLNEASVMKEFNCHHVVRLLGVVSQGQPT------LVIMELMTRGDLKSYLRSLRPEME 1099
Query: 630 DQPVYLPTQM--LVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKK 687
+ PV P + +++ +IA GM YL+ +F+HRDLAARNCM+ E+ +V + DFG+++
Sbjct: 1100 NNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRD 1159
Query: 688 IYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENS 747
IY DYYR+G +PV+W++ ESL D V+T+ SDVWSFGV +WEIAT + PY G+ N
Sbjct: 1160 IYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNE 1219
Query: 748 EIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLK 799
++ ++ +G L +P +C D L+ LM CW+ NP+ RPSF E+ ++ ++
Sbjct: 1220 QVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEME 1271
Score = 30.0 bits (66), Expect = 9.9
Identities = 18/51 (35%), Positives = 25/51 (49%), Gaps = 1/51 (1%)
Query: 324 LPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQ 374
L + T VP P + +SA+ + SQ V W P P G L Y + +Q Q
Sbjct: 602 LYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLP-NGNLSYYIVRWQRQ 651
>gi|42741655 met proto-oncogene isoform b precursor [Homo sapiens]
Length = 1390
Score = 234 bits (597), Expect = 3e-61
Identities = 126/288 (43%), Positives = 182/288 (63%), Gaps = 18/288 (6%)
Query: 509 ISEELKEKLRDVMVDRHK--VALGKTLGEGEFGAVMEGQL-NQDDSILKVAVKTMKIAIC 565
++ EL + ++ V++ V + +G G FG V G L + D + AVK++ I
Sbjct: 1058 LNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN-RIT 1116
Query: 566 TRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLY 625
E+ FL+E + MK+F HPNV+ L+G+C + S +P+V+LP+MKHGDL +F+
Sbjct: 1117 DIGEVSQFLTEGIIMKDFSHPNVLSLLGICLR-----SEGSPLVVLPYMKHGDLRNFIR- 1170
Query: 626 SRLGDQPVYLPT-QMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGL 684
+ PT + L+ F +A GM+YL++K+F+HRDLAARNCML+E +V VADFGL
Sbjct: 1171 -----NETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGL 1225
Query: 685 SKKIYNGDYY--RQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYP 742
++ +Y+ +YY AK+PVKW+A+ESL + +T+KSDVWSFGV +WE+ TRG PYP
Sbjct: 1226 ARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYP 1285
Query: 743 GVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTEL 790
V +I YL QG RL QP C D LY +M +CW + RPSF+EL
Sbjct: 1286 DVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSEL 1333
>gi|188595716 met proto-oncogene isoform a precursor [Homo sapiens]
Length = 1408
Score = 234 bits (597), Expect = 3e-61
Identities = 126/288 (43%), Positives = 182/288 (63%), Gaps = 18/288 (6%)
Query: 509 ISEELKEKLRDVMVDRHK--VALGKTLGEGEFGAVMEGQL-NQDDSILKVAVKTMKIAIC 565
++ EL + ++ V++ V + +G G FG V G L + D + AVK++ I
Sbjct: 1076 LNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN-RIT 1134
Query: 566 TRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLY 625
E+ FL+E + MK+F HPNV+ L+G+C + S +P+V+LP+MKHGDL +F+
Sbjct: 1135 DIGEVSQFLTEGIIMKDFSHPNVLSLLGICLR-----SEGSPLVVLPYMKHGDLRNFIR- 1188
Query: 626 SRLGDQPVYLPT-QMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGL 684
+ PT + L+ F +A GM+YL++K+F+HRDLAARNCML+E +V VADFGL
Sbjct: 1189 -----NETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGL 1243
Query: 685 SKKIYNGDYY--RQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYP 742
++ +Y+ +YY AK+PVKW+A+ESL + +T+KSDVWSFGV +WE+ TRG PYP
Sbjct: 1244 ARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYP 1303
Query: 743 GVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTEL 790
V +I YL QG RL QP C D LY +M +CW + RPSF+EL
Sbjct: 1304 DVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSEL 1351
>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
Length = 1370
Score = 229 bits (585), Expect = 7e-60
Identities = 168/541 (31%), Positives = 264/541 (48%), Gaps = 53/541 (9%)
Query: 276 PDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLG 335
P PEE + V L + L T Y I + + P + +P
Sbjct: 777 PTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEA 836
Query: 336 PPENISATRN-----GSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVT 390
++I + + WQEP+ P G ++ Y ++Y+ E+ + + R+
Sbjct: 837 KADDIVGPVTHEIFENNVVHLMWQEPKEP-NGLIVLYEVSYRRYGDEELHLCVS-RKHFA 894
Query: 391 LE----LQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPVKEPSTPA--FSWPWWYV 444
LE L+G S N +V + A + AG+G W+ P + PS A P +V
Sbjct: 895 LERGCRLRGL-SPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFV 953
Query: 445 LLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATL 504
L +VV + L L RK++ G L Y ++
Sbjct: 954 FLFSVVIGSIYLFL-------RKRQPD-----------GPLGPLYASSNPEYLSASDVFP 995
Query: 505 NSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLN---QDDSILKVAVKTMK 561
S+ + +E + V R K+ L + LG+G FG V EG + ++ +VAVKT+
Sbjct: 996 CSVYVPDEWE-------VSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN 1048
Query: 562 IAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHS 621
+ R +E FL+EA MK F +V+RL+GV +G +V++ M HGDL S
Sbjct: 1049 ESASLRERIE-FLNEASVMKGFTCHHVVRLLGVVSKGQPT------LVVMELMAHGDLKS 1101
Query: 622 FL--LYSRLGDQPVYLPT--QMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSV 677
+L L + P P Q +++ A+IA GM YL+ K+F+HRDLAARNCM+ + +V
Sbjct: 1102 YLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTV 1161
Query: 678 CVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRG 737
+ DFG+++ IY DYYR+G +PV+W+A ESL D V+T+ SD+WSFGV +WEI +
Sbjct: 1162 KIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLA 1221
Query: 738 QTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENT 797
+ PY G+ N ++ ++ G L QP +C + + LM CW+ NP+ RP+F E+ L++
Sbjct: 1222 EQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDD 1281
Query: 798 L 798
L
Sbjct: 1282 L 1282
>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
Length = 1382
Score = 229 bits (585), Expect = 7e-60
Identities = 168/541 (31%), Positives = 264/541 (48%), Gaps = 53/541 (9%)
Query: 276 PDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLG 335
P PEE + V L + L T Y I + + P + +P
Sbjct: 789 PTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEA 848
Query: 336 PPENISATRN-----GSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVT 390
++I + + WQEP+ P G ++ Y ++Y+ E+ + + R+
Sbjct: 849 KADDIVGPVTHEIFENNVVHLMWQEPKEP-NGLIVLYEVSYRRYGDEELHLCVS-RKHFA 906
Query: 391 LE----LQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPVKEPSTPA--FSWPWWYV 444
LE L+G S N +V + A + AG+G W+ P + PS A P +V
Sbjct: 907 LERGCRLRGL-SPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFV 965
Query: 445 LLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATL 504
L +VV + L L RK++ G L Y ++
Sbjct: 966 FLFSVVIGSIYLFL-------RKRQPD-----------GPLGPLYASSNPEYLSASDVFP 1007
Query: 505 NSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLN---QDDSILKVAVKTMK 561
S+ + +E + V R K+ L + LG+G FG V EG + ++ +VAVKT+
Sbjct: 1008 CSVYVPDEWE-------VSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN 1060
Query: 562 IAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHS 621
+ R +E FL+EA MK F +V+RL+GV +G +V++ M HGDL S
Sbjct: 1061 ESASLRERIE-FLNEASVMKGFTCHHVVRLLGVVSKGQPT------LVVMELMAHGDLKS 1113
Query: 622 FL--LYSRLGDQPVYLPT--QMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSV 677
+L L + P P Q +++ A+IA GM YL+ K+F+HRDLAARNCM+ + +V
Sbjct: 1114 YLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTV 1173
Query: 678 CVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRG 737
+ DFG+++ IY DYYR+G +PV+W+A ESL D V+T+ SD+WSFGV +WEI +
Sbjct: 1174 KIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLA 1233
Query: 738 QTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENT 797
+ PY G+ N ++ ++ G L QP +C + + LM CW+ NP+ RP+F E+ L++
Sbjct: 1234 EQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDD 1293
Query: 798 L 798
L
Sbjct: 1294 L 1294
>gi|153946393 macrophage stimulating 1 receptor precursor [Homo
sapiens]
Length = 1400
Score = 222 bits (566), Expect = 1e-57
Identities = 121/299 (40%), Positives = 185/299 (61%), Gaps = 18/299 (6%)
Query: 509 ISEELKEKLRDVMVDRHKVAL--GKTLGEGEFGAVMEGQ-LNQDDSILKVAVKTMKIAIC 565
+ L +++DV++ +V + +G+G FG V G+ ++Q + ++ A+K++ I
Sbjct: 1062 LDSALLAEVKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLS-RIT 1120
Query: 566 TRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLY 625
++E FL E + M+ +HPNV+ LIG+ P V+LP+M HGDL F+
Sbjct: 1121 EMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEG-----LPHVLLPYMCHGDLLQFIR- 1174
Query: 626 SRLGDQPVYLPT-QMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGL 684
P PT + L+ F +A GMEYL+ ++F+HRDLAARNCML+E+ +V VADFGL
Sbjct: 1175 -----SPQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGL 1229
Query: 685 SKKIYNGDYY--RQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYP 742
++ I + +YY +Q R A++PVKW+A+ESL +T+KSDVWSFGV +WE+ TRG PY
Sbjct: 1230 ARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYR 1289
Query: 743 GVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKAL 801
++ ++ +L QG RL QP C D LY +M +CWE +P RP+F L ++E + AL
Sbjct: 1290 HIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSAL 1348
>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
Length = 2347
Score = 220 bits (561), Expect = 4e-57
Identities = 167/542 (30%), Positives = 257/542 (47%), Gaps = 59/542 (10%)
Query: 284 TSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISAT 343
TS + P + + +L P+T Y++RV G +S + +T GVP P I
Sbjct: 1704 TSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENSTSLPESFKTKAGVPNKP--GIPKL 1761
Query: 344 RNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLT 403
GS+ + W+ +A G + Y + + T L + LR ++T +GS S++
Sbjct: 1762 LEGSKNSIQWE--KAEDNGCRITYYILEIRKSTSNNLQNQNLRWKMTF----NGSCSSVC 1815
Query: 404 VC------------VAAYTAAGDGPWS------LPVPLEAWRPVKEPSTPAFSWPWWYVL 445
V A G G +S + V + W P ++L
Sbjct: 1816 TWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPETS-----------FIL 1864
Query: 446 LGAVVAAACVLILALFLVHRRKKETRYGEVFEPTV--ERGELVVRYRVRKSYSRRTTEAT 503
V V I F+ HRR K + + + E EL +
Sbjct: 1865 TIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYA 1924
Query: 504 LNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQ----LNQDDSILKVAVKT 559
+++L EE++ R K+ L LG G FG V EG L +KVAVKT
Sbjct: 1925 IHTLPTQEEIENL---PAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKT 1981
Query: 560 MKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDL 619
+K + ++E FL EA M +F+HPN+++ +GVC + +IL M+ GDL
Sbjct: 1982 LKKGSTDQEKIE-FLKEAHLMSKFNHPNILKQLGVCLLNEPQ------YIILELMEGGDL 2034
Query: 620 HSFLLYSRLGDQPVYLPTQM-LVKFMADIASGMEYLSTKRFIHRDLAARNCMLNEN---- 674
++L +R+ L T + LV DI+ G YL FIHRDLAARNC+++
Sbjct: 2035 LTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTS 2094
Query: 675 -MSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEI 733
V + DFGL++ IY DYYR+ +PV+W+A ESL D ++T++SDVWSFG+ +WEI
Sbjct: 2095 PRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEI 2154
Query: 734 ATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELRED 793
T G PYP N ++ +Y++ G RL+ P +C D L+ LM++CW P RP+F +++
Sbjct: 2155 LTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQ 2214
Query: 794 LE 795
L+
Sbjct: 2215 LQ 2216
Score = 31.2 bits (69), Expect = 4.4
Identities = 36/139 (25%), Positives = 46/139 (33%), Gaps = 34/139 (24%)
Query: 316 GPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLL---------- 365
G SS H LP G P+ +S QA V W+ P + ++
Sbjct: 549 GSSSQLHPLP---------GRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFE 599
Query: 366 ---------GYRLAYQGQDTPEV---LMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAG 413
Y + QD PEV ++I ELQ S V V A +
Sbjct: 600 LGPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQ---SAMKYKVSVRASSPKR 656
Query: 414 DGPWSLPVPLEAWRPVKEP 432
GPWS P P EP
Sbjct: 657 PGPWSEPSVGTTLVPASEP 675
>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
Length = 1620
Score = 218 bits (555), Expect = 2e-56
Identities = 134/382 (35%), Positives = 203/382 (53%), Gaps = 42/382 (10%)
Query: 444 VLLGAVVAAACVLILALFLVHRRKKETRYG---EVFEPTVERGEL-----VVRYRVRKSY 495
V+ A+VAA + + +V+RRK + E+ P + +L + Y +
Sbjct: 1039 VVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCF 1098
Query: 496 SRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLN---QDDSI 552
+ +T+ + +LKE V R + L + LG G FG V EGQ++ D S
Sbjct: 1099 AGKTSSIS--------DLKE------VPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSP 1144
Query: 553 LKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILP 612
L+VAVKT+ +C+ + DFL EA+ + +F+H N++R IGV Q R ++L
Sbjct: 1145 LQVAVKTLP-EVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPR------FILLE 1197
Query: 613 FMKHGDLHSFLLYSR-LGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCML 671
M GDL SFL +R QP L L+ DIA G +YL FIHRD+AARNC+L
Sbjct: 1198 LMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLL 1257
Query: 672 N---ENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGV 728
+ DFG+++ IY YYR+G A +PVKW+ E+ + ++TSK+D WSFGV
Sbjct: 1258 TCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGV 1317
Query: 729 TMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFT 788
+WEI + G PYP N E+ +++ G R+ P +C +Y +M++CW+ P+DRP+F
Sbjct: 1318 LLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFA 1377
Query: 789 ELREDLENTLKALPPAQEPDEI 810
+ E +E Q+PD I
Sbjct: 1378 IILERIEYC------TQDPDVI 1393
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 216 bits (549), Expect = 1e-55
Identities = 122/290 (42%), Positives = 173/290 (59%), Gaps = 16/290 (5%)
Query: 522 VDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMK 581
++R + + LG G++G V EG + L VAVKT+K E+E+FL EA MK
Sbjct: 237 MERTDITMKHKLGGGQYGEVYEGVWKKYS--LTVAVKTLKE---DTMEVEEFLKEAAVMK 291
Query: 582 EFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLV 641
E HPN+++L+GVC RE P +I FM +G+L +L + + +L+
Sbjct: 292 EIKHPNLVQLLGVC----TRE--PPFYIITEFMTYGNLLDYLRECNRQE----VNAVVLL 341
Query: 642 KFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAK 701
I+S MEYL K FIHRDLAARNC++ EN V VADFGLS+ + GD Y AK
Sbjct: 342 YMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR-LMTGDTYTAHAGAK 400
Query: 702 MPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQ 761
P+KW A ESLA ++ KSDVW+FGV +WEIAT G +PYPG++ S++Y+ L + R+++
Sbjct: 401 FPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMER 460
Query: 762 PADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEIL 811
P C + +Y LM CW+ NP DRPSF E+ + E + + E ++ L
Sbjct: 461 PEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKEL 510
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 216 bits (549), Expect = 1e-55
Identities = 122/290 (42%), Positives = 173/290 (59%), Gaps = 16/290 (5%)
Query: 522 VDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMK 581
++R + + LG G++G V EG + L VAVKT+K E+E+FL EA MK
Sbjct: 256 MERTDITMKHKLGGGQYGEVYEGVWKKYS--LTVAVKTLKE---DTMEVEEFLKEAAVMK 310
Query: 582 EFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLV 641
E HPN+++L+GVC RE P +I FM +G+L +L + + +L+
Sbjct: 311 EIKHPNLVQLLGVC----TRE--PPFYIITEFMTYGNLLDYLRECNRQE----VNAVVLL 360
Query: 642 KFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAK 701
I+S MEYL K FIHRDLAARNC++ EN V VADFGLS+ + GD Y AK
Sbjct: 361 YMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR-LMTGDTYTAHAGAK 419
Query: 702 MPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQ 761
P+KW A ESLA ++ KSDVW+FGV +WEIAT G +PYPG++ S++Y+ L + R+++
Sbjct: 420 FPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMER 479
Query: 762 PADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEIL 811
P C + +Y LM CW+ NP DRPSF E+ + E + + E ++ L
Sbjct: 480 PEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKEL 529
>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
Length = 1124
Score = 215 bits (547), Expect = 2e-55
Identities = 177/603 (29%), Positives = 285/603 (47%), Gaps = 64/603 (10%)
Query: 218 TATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPD 277
TA+I + P PR L+L+ + T L + W P I+P S+D ++ E
Sbjct: 538 TASIGLPP--PRGLNLLPKSQTTLNLTWQP----IFPS---------SEDDFYVEV-ERR 581
Query: 278 PPEEPLTSQASVPPH--QLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLG 335
++ VP + + L +LHP Y +R A +++ W+ L T +
Sbjct: 582 SVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVR-ARVNTKAQGEWSEDLTAWTLSDILPP 640
Query: 336 PPENISATR-NGSQAFVHWQEPRA-PLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLEL 393
PENI + S A + W + + Y++ + +D +D+ ++ +
Sbjct: 641 QPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQH---VDVKIKNATITQY 697
Query: 394 QGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPVKEPSTPAFSWPWWYVLLGAVVAAA 453
Q G V + G S P + E PA +LL A++ +A
Sbjct: 698 QLKGLEPETAYQVDIFAENNIGS-SNPAFSHELVTLPESQAPA-DLGGGKMLLIAILGSA 755
Query: 454 ---CVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGIS 510
C+ +L FL+ + K V+R VR+ + + TL ++
Sbjct: 756 GMTCLTVLLAFLIILQLKRAN--------VQRRMAQAFQNVREEPAVQFNSGTL---ALN 804
Query: 511 EELKEKLRDVM---VDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTR 567
++K + +D + + +GEG FG V++ ++ +D + A+K MK ++
Sbjct: 805 RKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMK-EYASK 863
Query: 568 SELEDFLSEA-VCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYS 626
+ DF E V K HPN++ L+G C E + + + HG+L FL S
Sbjct: 864 DDHRDFAGELEVLCKLGHHPNIINLLGAC------EHRGYLYLAIEYAPHGNLLDFLRKS 917
Query: 627 R-LGDQPVY---------LPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMS 676
R L P + L +Q L+ F AD+A GM+YLS K+FIHRDLAARN ++ EN
Sbjct: 918 RVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYV 977
Query: 677 VCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATR 736
+ADFGLS+ + Y + + ++PV+W+AIESL VYT+ SDVWS+GV +WEI +
Sbjct: 978 AKIADFGLSR---GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSL 1034
Query: 737 GQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLEN 796
G TPY G+ +E+Y+ L QG RL++P +C D +Y LM +CW P +RPSF ++ L
Sbjct: 1035 GGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNR 1094
Query: 797 TLK 799
L+
Sbjct: 1095 MLE 1097
>gi|31657140 insulin receptor-related receptor precursor [Homo
sapiens]
Length = 1297
Score = 214 bits (546), Expect = 2e-55
Identities = 180/582 (30%), Positives = 271/582 (46%), Gaps = 85/582 (14%)
Query: 289 VPPHQLRLGSLHPHTPYHIRV-ACTSSQ---GPSSWTHWLPVETPEGVPLGPPENIS-AT 343
VP + L L T Y I + AC + G S+ T P G P ++
Sbjct: 767 VPRERAVLSGLRHFTEYRIDIHACNHAAHTVGCSAATFVFARTMPHREADGIPGKVAWEA 826
Query: 344 RNGSQAFVHWQEPRAPLQGTLLGYRLAYQ--GQDTPEVLMDIGLRQE----VTLELQGDG 397
+ + + W EP P G +L Y + Y+ G++ VL LR V L L G
Sbjct: 827 SSKNSVLLRWLEPPDP-NGLILKYEIKYRRLGEEAT-VLCVSRLRYAKFGGVHLALLPPG 884
Query: 398 SVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPVKEPSTPAFSWPWWYVLLGAVVAAACVLI 457
N + V A + AG+G W+ V P +E + +VLL A +LI
Sbjct: 885 ---NYSARVRATSLAGNGSWTDSVAFYILGPEEEDAGGL------HVLLTATPVGLTLLI 935
Query: 458 LAL---FLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELK 514
+ F +++ T Y V ++ V +E +
Sbjct: 936 VLAALGFFYGKKRNRTLYASVNPEYFSASDMYV----------------------PDEWE 973
Query: 515 EKLRDVMVDRHKVALGKTLGEGEFGAVMEGQ---LNQDDSILKVAVKTMKIAICTRSELE 571
V R ++++ + LG+G FG V EG L + VA+KT+ + + E
Sbjct: 974 -------VPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVN-ELASPRECI 1025
Query: 572 DFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRL-GD 630
+FL EA MK F +V+RL+GV QG +VI+ M GDL S L R +
Sbjct: 1026 EFLKEASVMKAFKCHHVVRLLGVVSQGQPT------LVIMELMTRGDLKSHLRSLRPEAE 1079
Query: 631 QPVYLPTQML---VKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKK 687
LP L ++ +IA GM YL+ +F+HRDLAARNCM++++ +V + DFG+++
Sbjct: 1080 NNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRD 1139
Query: 688 IYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENS 747
+Y DYYR+G +PV+W+A ESL D ++T+ SDVWSFGV +WEI T + PY G+ N
Sbjct: 1140 VYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNE 1199
Query: 748 EIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEP 807
++ ++ G L++ C L LMSRCW+ NP+ RPSFT + + ++ L+ P+
Sbjct: 1200 QVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEELR---PSFRL 1256
Query: 808 DEILYVNMDEGGGYPEPPGAAGG-----ADPPTQPDPKDSCS 844
Y PE GA G A+P + P P+D CS
Sbjct: 1257 LSFYY--------SPECRGARGSLPTTDAEPDSSPTPRD-CS 1289
>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
Length = 1074
Score = 213 bits (542), Expect = 6e-55
Identities = 123/334 (36%), Positives = 188/334 (56%), Gaps = 29/334 (8%)
Query: 518 RDVMVDRHKVALGKTLGEGEFGAVMEG-QLNQDDSILKVAVKTMKIAICTRSEL-EDFLS 575
RD + R ++ LG+ +GEG+FG V +G ++ ++ L VA+KT K CT + E FL
Sbjct: 435 RDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKN--CTSDSVREKFLQ 492
Query: 576 EAVCMKEFDHPNVMRLIGVCFQGSERESFPAPV-VILPFMKHGDLHSFLLYSRLGDQPVY 634
EA+ M++FDHP++++LIGV + PV +I+ G+L SFL +
Sbjct: 493 EALTMRQFDHPHIVKLIGVITEN--------PVWIIMELCTLGELRSFLQVRKYS----- 539
Query: 635 LPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYY 694
L L+ + +++ + YL +KRF+HRD+AARN +++ N V + DFGLS+ + + YY
Sbjct: 540 LDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYY 599
Query: 695 RQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLR 754
+ + K+P+KW+A ES+ R +TS SDVW FGV MWEI G P+ GV+N+++ +
Sbjct: 600 KASK-GKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIE 658
Query: 755 QGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEIL--- 811
G RL P +C LY+LM++CW +P RP FTEL+ L L+ QE +
Sbjct: 659 NGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESR 718
Query: 812 ---YVNMDEGGGYPEPPGAAGGADPPTQPDPKDS 842
V+ D GG PP + P P P+ S
Sbjct: 719 RQATVSWDSGGSDEAPPKPS----RPGYPSPRSS 748
>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
Length = 1052
Score = 213 bits (542), Expect = 6e-55
Identities = 123/334 (36%), Positives = 188/334 (56%), Gaps = 29/334 (8%)
Query: 518 RDVMVDRHKVALGKTLGEGEFGAVMEG-QLNQDDSILKVAVKTMKIAICTRSEL-EDFLS 575
RD + R ++ LG+ +GEG+FG V +G ++ ++ L VA+KT K CT + E FL
Sbjct: 413 RDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKN--CTSDSVREKFLQ 470
Query: 576 EAVCMKEFDHPNVMRLIGVCFQGSERESFPAPV-VILPFMKHGDLHSFLLYSRLGDQPVY 634
EA+ M++FDHP++++LIGV + PV +I+ G+L SFL +
Sbjct: 471 EALTMRQFDHPHIVKLIGVITEN--------PVWIIMELCTLGELRSFLQVRKYS----- 517
Query: 635 LPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYY 694
L L+ + +++ + YL +KRF+HRD+AARN +++ N V + DFGLS+ + + YY
Sbjct: 518 LDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYY 577
Query: 695 RQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLR 754
+ + K+P+KW+A ES+ R +TS SDVW FGV MWEI G P+ GV+N+++ +
Sbjct: 578 KASK-GKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIE 636
Query: 755 QGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEIL--- 811
G RL P +C LY+LM++CW +P RP FTEL+ L L+ QE +
Sbjct: 637 NGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESR 696
Query: 812 ---YVNMDEGGGYPEPPGAAGGADPPTQPDPKDS 842
V+ D GG PP + P P P+ S
Sbjct: 697 RQATVSWDSGGSDEAPPKPS----RPGYPSPRSS 726
>gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precursor
[Homo sapiens]
Length = 864
Score = 213 bits (541), Expect = 8e-55
Identities = 139/396 (35%), Positives = 213/396 (53%), Gaps = 25/396 (6%)
Query: 444 VLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEAT 503
VL+ AVVA + + +L + V K+ ++ + E + EL + ++R S R
Sbjct: 426 VLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELS-KLRTSAIRTAPNPY 484
Query: 504 LNSLGISEELKEKLRDVM--VDRHKVALGKTLGEGEFGAVMEGQ---LNQDDSILKVAVK 558
+G+ L + V V L + LG G FG V EG L D S L+VA+K
Sbjct: 485 YCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIK 544
Query: 559 TMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGD 618
T+ +C+ + DFL EA+ + +F H N++R +G+ + + R +++L M GD
Sbjct: 545 TLP-ELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPR------LILLELMSGGD 597
Query: 619 LHSFLLYSR--LGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLN---E 673
+ SFL +SR LG QP L + L++ DIA G YL FIHRD+AARNC+L+
Sbjct: 598 MKSFLRHSRPHLG-QPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGP 656
Query: 674 NMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEI 733
+ + DFG+++ IY YYR+G A +PVKW+ E+ + ++TSK+D WSFGV +WEI
Sbjct: 657 SRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEI 716
Query: 734 ATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELRED 793
+ G PYPG N E+ D++ G R+ P C +Y +M++CW+ P+ RPSF + E
Sbjct: 717 FSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILER 776
Query: 794 LENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAG 829
L+ Q+PD + + E G PE G +G
Sbjct: 777 LQYC------TQDPDVLNSLLPMELGPTPEEEGTSG 806
>gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precursor
[Homo sapiens]
Length = 803
Score = 213 bits (541), Expect = 8e-55
Identities = 139/396 (35%), Positives = 213/396 (53%), Gaps = 25/396 (6%)
Query: 444 VLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEAT 503
VL+ AVVA + + +L + V K+ ++ + E + EL + ++R S R
Sbjct: 365 VLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELS-KLRTSAIRTAPNPY 423
Query: 504 LNSLGISEELKEKLRDVM--VDRHKVALGKTLGEGEFGAVMEGQ---LNQDDSILKVAVK 558
+G+ L + V V L + LG G FG V EG L D S L+VA+K
Sbjct: 424 YCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIK 483
Query: 559 TMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGD 618
T+ +C+ + DFL EA+ + +F H N++R +G+ + + R +++L M GD
Sbjct: 484 TLP-ELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPR------LILLELMSGGD 536
Query: 619 LHSFLLYSR--LGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLN---E 673
+ SFL +SR LG QP L + L++ DIA G YL FIHRD+AARNC+L+
Sbjct: 537 MKSFLRHSRPHLG-QPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGP 595
Query: 674 NMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEI 733
+ + DFG+++ IY YYR+G A +PVKW+ E+ + ++TSK+D WSFGV +WEI
Sbjct: 596 SRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEI 655
Query: 734 ATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELRED 793
+ G PYPG N E+ D++ G R+ P C +Y +M++CW+ P+ RPSF + E
Sbjct: 656 FSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILER 715
Query: 794 LENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAG 829
L+ Q+PD + + E G PE G +G
Sbjct: 716 LQYC------TQDPDVLNSLLPMELGPTPEEEGTSG 745
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 212 bits (539), Expect = 1e-54
Identities = 119/275 (43%), Positives = 166/275 (60%), Gaps = 18/275 (6%)
Query: 522 VDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMK 581
++R + + LG G++G V G + L VAVKT+K E+E+FL EA MK
Sbjct: 268 MERTDITMKHKLGGGQYGEVYVGVWKKYS--LTVAVKTLKE---DTMEVEEFLKEAAVMK 322
Query: 582 EFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLV 641
E HPN+++L+GVC P ++ +M +G+L +L + T +++
Sbjct: 323 EIKHPNLVQLLGVCTLE------PPFYIVTEYMPYGNLLDYLRECNREEV-----TAVVL 371
Query: 642 KFMA-DIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIA 700
+MA I+S MEYL K FIHRDLAARNC++ EN V VADFGLS+ + GD Y A
Sbjct: 372 LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGA 430
Query: 701 KMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLK 760
K P+KW A ESLA ++ KSDVW+FGV +WEIAT G +PYPG++ S++YD L +G R++
Sbjct: 431 KFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRME 490
Query: 761 QPADCLDGLYALMSRCWELNPQDRPSFTELREDLE 795
QP C +Y LM CW+ +P DRPSF E + E
Sbjct: 491 QPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE 525
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 212 bits (539), Expect = 1e-54
Identities = 119/275 (43%), Positives = 166/275 (60%), Gaps = 18/275 (6%)
Query: 522 VDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMK 581
++R + + LG G++G V G + L VAVKT+K E+E+FL EA MK
Sbjct: 283 MERTDITMKHKLGGGQYGEVYVGVWKKYS--LTVAVKTLKE---DTMEVEEFLKEAAVMK 337
Query: 582 EFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLV 641
E HPN+++L+GVC P ++ +M +G+L +L + T +++
Sbjct: 338 EIKHPNLVQLLGVCTLE------PPFYIVTEYMPYGNLLDYLRECNREEV-----TAVVL 386
Query: 642 KFMA-DIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIA 700
+MA I+S MEYL K FIHRDLAARNC++ EN V VADFGLS+ + GD Y A
Sbjct: 387 LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGA 445
Query: 701 KMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLK 760
K P+KW A ESLA ++ KSDVW+FGV +WEIAT G +PYPG++ S++YD L +G R++
Sbjct: 446 KFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRME 505
Query: 761 QPADCLDGLYALMSRCWELNPQDRPSFTELREDLE 795
QP C +Y LM CW+ +P DRPSF E + E
Sbjct: 506 QPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE 540
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 212 bits (539), Expect = 1e-54
Identities = 119/275 (43%), Positives = 166/275 (60%), Gaps = 18/275 (6%)
Query: 522 VDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMK 581
++R + + LG G++G V G + L VAVKT+K E+E+FL EA MK
Sbjct: 262 MERTDITMKHKLGGGQYGEVYVGVWKKYS--LTVAVKTLKE---DTMEVEEFLKEAAVMK 316
Query: 582 EFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLV 641
E HPN+++L+GVC P ++ +M +G+L +L + T +++
Sbjct: 317 EIKHPNLVQLLGVCTLE------PPFYIVTEYMPYGNLLDYLRECNREEV-----TAVVL 365
Query: 642 KFMA-DIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIA 700
+MA I+S MEYL K FIHRDLAARNC++ EN V VADFGLS+ + GD Y A
Sbjct: 366 LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGA 424
Query: 701 KMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLK 760
K P+KW A ESLA ++ KSDVW+FGV +WEIAT G +PYPG++ S++YD L +G R++
Sbjct: 425 KFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRME 484
Query: 761 QPADCLDGLYALMSRCWELNPQDRPSFTELREDLE 795
QP C +Y LM CW+ +P DRPSF E + E
Sbjct: 485 QPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE 519
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 212 bits (539), Expect = 1e-54
Identities = 119/275 (43%), Positives = 166/275 (60%), Gaps = 18/275 (6%)
Query: 522 VDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMK 581
++R + + LG G++G V G + L VAVKT+K E+E+FL EA MK
Sbjct: 268 MERTDITMKHKLGGGQYGEVYVGVWKKYS--LTVAVKTLKE---DTMEVEEFLKEAAVMK 322
Query: 582 EFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLV 641
E HPN+++L+GVC P ++ +M +G+L +L + T +++
Sbjct: 323 EIKHPNLVQLLGVCTLE------PPFYIVTEYMPYGNLLDYLRECNREEV-----TAVVL 371
Query: 642 KFMA-DIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIA 700
+MA I+S MEYL K FIHRDLAARNC++ EN V VADFGLS+ + GD Y A
Sbjct: 372 LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGA 430
Query: 701 KMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLK 760
K P+KW A ESLA ++ KSDVW+FGV +WEIAT G +PYPG++ S++YD L +G R++
Sbjct: 431 KFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRME 490
Query: 761 QPADCLDGLYALMSRCWELNPQDRPSFTELREDLE 795
QP C +Y LM CW+ +P DRPSF E + E
Sbjct: 491 QPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE 525
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 212 bits (539), Expect = 1e-54
Identities = 119/275 (43%), Positives = 166/275 (60%), Gaps = 18/275 (6%)
Query: 522 VDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMK 581
++R + + LG G++G V G + L VAVKT+K E+E+FL EA MK
Sbjct: 247 MERTDITMKHKLGGGQYGEVYVGVWKKYS--LTVAVKTLKE---DTMEVEEFLKEAAVMK 301
Query: 582 EFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLV 641
E HPN+++L+GVC P ++ +M +G+L +L + T +++
Sbjct: 302 EIKHPNLVQLLGVCTLE------PPFYIVTEYMPYGNLLDYLRECNREEV-----TAVVL 350
Query: 642 KFMA-DIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIA 700
+MA I+S MEYL K FIHRDLAARNC++ EN V VADFGLS+ + GD Y A
Sbjct: 351 LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGA 409
Query: 701 KMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLK 760
K P+KW A ESLA ++ KSDVW+FGV +WEIAT G +PYPG++ S++YD L +G R++
Sbjct: 410 KFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRME 469
Query: 761 QPADCLDGLYALMSRCWELNPQDRPSFTELREDLE 795
QP C +Y LM CW+ +P DRPSF E + E
Sbjct: 470 QPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE 504
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 211 bits (538), Expect = 2e-54
Identities = 138/378 (36%), Positives = 210/378 (55%), Gaps = 31/378 (8%)
Query: 496 SRRTTEATLNSLGISE-ELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQ---LNQD-- 549
SR ++ T G+SE EL E R + R ++ LGK LGEG FG V+ + L++D
Sbjct: 356 SRLSSSGTPMLAGVSEYELPEDPRWEL-PRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKP 414
Query: 550 DSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFD-HPNVMRLIGVCFQGSERESFPAPV 608
+ + KVAVK +K + T +L D +SE MK H N++ L+G C Q
Sbjct: 415 NRVTKVAVKMLK-SDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPL------Y 467
Query: 609 VILPFMKHGDLHSFL----------LYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKR 658
VI+ + G+L +L Y+ + L ++ LV +A GMEYL++K+
Sbjct: 468 VIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKK 527
Query: 659 FIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYT 718
IHRDLAARN ++ E+ + +ADFGL++ I++ DYY++ ++PVKW+A E+L DR+YT
Sbjct: 528 CIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYT 587
Query: 719 SKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWE 778
+SDVWSFGV +WEI T G +PYPGV E++ L++G+R+ +P++C + LY +M CW
Sbjct: 588 HQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWH 647
Query: 779 LNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGA--AGGADPPTQ 836
P RP+F +L EDL+ + AL QE ++ +P+ + + G D
Sbjct: 648 AVPSQRPTFKQLVEDLDR-IVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFS 706
Query: 837 PDPKDSCSCLTAAEVHPA 854
+P CL HPA
Sbjct: 707 HEPLPEEPCLPR---HPA 721
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 211 bits (538), Expect = 2e-54
Identities = 138/378 (36%), Positives = 210/378 (55%), Gaps = 31/378 (8%)
Query: 496 SRRTTEATLNSLGISE-ELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQ---LNQD-- 549
SR ++ T G+SE EL E R + R ++ LGK LGEG FG V+ + L++D
Sbjct: 358 SRLSSSGTPMLAGVSEYELPEDPRWEL-PRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKP 416
Query: 550 DSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFD-HPNVMRLIGVCFQGSERESFPAPV 608
+ + KVAVK +K + T +L D +SE MK H N++ L+G C Q
Sbjct: 417 NRVTKVAVKMLK-SDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPL------Y 469
Query: 609 VILPFMKHGDLHSFL----------LYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKR 658
VI+ + G+L +L Y+ + L ++ LV +A GMEYL++K+
Sbjct: 470 VIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKK 529
Query: 659 FIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYT 718
IHRDLAARN ++ E+ + +ADFGL++ I++ DYY++ ++PVKW+A E+L DR+YT
Sbjct: 530 CIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYT 589
Query: 719 SKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWE 778
+SDVWSFGV +WEI T G +PYPGV E++ L++G+R+ +P++C + LY +M CW
Sbjct: 590 HQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWH 649
Query: 779 LNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGA--AGGADPPTQ 836
P RP+F +L EDL+ + AL QE ++ +P+ + + G D
Sbjct: 650 AVPSQRPTFKQLVEDLDR-IVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFS 708
Query: 837 PDPKDSCSCLTAAEVHPA 854
+P CL HPA
Sbjct: 709 HEPLPEEPCLPR---HPA 723
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 211 bits (538), Expect = 2e-54
Identities = 138/378 (36%), Positives = 210/378 (55%), Gaps = 31/378 (8%)
Query: 496 SRRTTEATLNSLGISE-ELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQ---LNQD-- 549
SR ++ T G+SE EL E R + R ++ LGK LGEG FG V+ + L++D
Sbjct: 445 SRLSSSGTPMLAGVSEYELPEDPRWEL-PRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKP 503
Query: 550 DSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFD-HPNVMRLIGVCFQGSERESFPAPV 608
+ + KVAVK +K + T +L D +SE MK H N++ L+G C Q
Sbjct: 504 NRVTKVAVKMLK-SDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPL------Y 556
Query: 609 VILPFMKHGDLHSFL----------LYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKR 658
VI+ + G+L +L Y+ + L ++ LV +A GMEYL++K+
Sbjct: 557 VIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKK 616
Query: 659 FIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYT 718
IHRDLAARN ++ E+ + +ADFGL++ I++ DYY++ ++PVKW+A E+L DR+YT
Sbjct: 617 CIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYT 676
Query: 719 SKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWE 778
+SDVWSFGV +WEI T G +PYPGV E++ L++G+R+ +P++C + LY +M CW
Sbjct: 677 HQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWH 736
Query: 779 LNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGA--AGGADPPTQ 836
P RP+F +L EDL+ + AL QE ++ +P+ + + G D
Sbjct: 737 AVPSQRPTFKQLVEDLDR-IVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFS 795
Query: 837 PDPKDSCSCLTAAEVHPA 854
+P CL HPA
Sbjct: 796 HEPLPEEPCLPR---HPA 810
Score = 36.6 bits (83), Expect = 0.11
Identities = 48/224 (21%), Positives = 85/224 (37%), Gaps = 52/224 (23%)
Query: 2 AWRCPRMGRVPLAWCLALCGWACMA-----------PRGTQAEESPFVGNPGNITGARGL 50
+W+C L W + + C A P G E F+ +PG++
Sbjct: 3 SWKCL------LFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLL----- 51
Query: 51 TGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLS 110
LRC+L+ + ++WLRDG ++LA+S +T++ E E D + +
Sbjct: 52 --QLRCRLR--DDVQSINWLRDG--VQLAESNRTRITGEEVEVQDSVP-----------A 94
Query: 111 DTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVD 170
D+G Y C+ + + + LP ++ +D ++ + + P PV
Sbjct: 95 DSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTK----PNPVA 150
Query: 171 LLWLQDAVPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVT 214
W T+P ++ LH KT F C + T
Sbjct: 151 PYW--------TSP-EKMEKKLHAVPAAKTVKFKCPSSGTPNPT 185
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 211 bits (538), Expect = 2e-54
Identities = 124/329 (37%), Positives = 183/329 (55%), Gaps = 37/329 (11%)
Query: 524 RHKVALGKTLGEGEFGAVMEG---QLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCM 580
R + LGKTLGEGEFG V++ L VAVK +K + SEL D LSE +
Sbjct: 721 RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-ENASPSELRDLLSEFNVL 779
Query: 581 KEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSR------LG----- 629
K+ +HP+V++L G C Q ++I+ + K+G L FL SR LG
Sbjct: 780 KQVNHPHVIKLYGACSQDGPL------LLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSR 833
Query: 630 -----DQPVYLPTQM--LVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADF 682
D P M L+ F I+ GM+YL+ + +HRDLAARN ++ E + ++DF
Sbjct: 834 NSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDF 893
Query: 683 GLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYP 742
GLS+ +Y D Y + ++PVKW+AIESL D +YT++SDVWSFGV +WEI T G PYP
Sbjct: 894 GLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYP 953
Query: 743 GVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKA-- 800
G+ +++ L+ G+R+++P +C + +Y LM +CW+ P RP F ++ +DLE +
Sbjct: 954 GIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRR 1013
Query: 801 ----LPPAQEPDEILYVNMDEGGGYPEPP 825
L + D ++Y D+G E P
Sbjct: 1014 DYLDLAASTPSDSLIY---DDGLSEEETP 1039
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 211 bits (538), Expect = 2e-54
Identities = 124/329 (37%), Positives = 183/329 (55%), Gaps = 37/329 (11%)
Query: 524 RHKVALGKTLGEGEFGAVMEG---QLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCM 580
R + LGKTLGEGEFG V++ L VAVK +K + SEL D LSE +
Sbjct: 721 RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-ENASPSELRDLLSEFNVL 779
Query: 581 KEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSR------LG----- 629
K+ +HP+V++L G C Q ++I+ + K+G L FL SR LG
Sbjct: 780 KQVNHPHVIKLYGACSQDGPL------LLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSR 833
Query: 630 -----DQPVYLPTQM--LVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADF 682
D P M L+ F I+ GM+YL+ + +HRDLAARN ++ E + ++DF
Sbjct: 834 NSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDF 893
Query: 683 GLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYP 742
GLS+ +Y D Y + ++PVKW+AIESL D +YT++SDVWSFGV +WEI T G PYP
Sbjct: 894 GLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYP 953
Query: 743 GVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKA-- 800
G+ +++ L+ G+R+++P +C + +Y LM +CW+ P RP F ++ +DLE +
Sbjct: 954 GIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRR 1013
Query: 801 ----LPPAQEPDEILYVNMDEGGGYPEPP 825
L + D ++Y D+G E P
Sbjct: 1014 DYLDLAASTPSDSLIY---DDGLSEEETP 1039
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,210,339
Number of Sequences: 37866
Number of extensions: 2263535
Number of successful extensions: 12383
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 606
Number of HSP's successfully gapped in prelim test: 473
Number of HSP's that attempted gapping in prelim test: 8761
Number of HSP's gapped (non-prelim): 2689
length of query: 885
length of database: 18,247,518
effective HSP length: 111
effective length of query: 774
effective length of database: 14,044,392
effective search space: 10870359408
effective search space used: 10870359408
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.