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Search of human proteins with 21536376
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo
sapiens]
(2261 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo sa... 4548 0.0
gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo s... 2239 0.0
gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo ... 2052 0.0
gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform... 1514 0.0
gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform... 1514 0.0
gi|27881501 ATP-binding cassette, sub-family A, member 12 isofor... 1179 0.0
gi|30795238 ATP-binding cassette, sub-family A, member 12 isofor... 1179 0.0
gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13... 1073 0.0
gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo s... 538 e-152
gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo... 302 3e-81
gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo ... 297 7e-80
gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo ... 297 7e-80
gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo s... 287 7e-77
gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo s... 276 1e-73
gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sap... 260 9e-69
gi|169210363 PREDICTED: similar to hCG18626 [Homo sapiens] 152 3e-36
gi|169210679 PREDICTED: similar to hCG18626 [Homo sapiens] 152 3e-36
gi|169209894 PREDICTED: similar to hCG18626 [Homo sapiens] 152 3e-36
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 95 9e-19
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 92 8e-18
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 92 8e-18
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 92 8e-18
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 91 1e-17
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 88 1e-16
gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7... 86 5e-16
gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6... 86 5e-16
gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5... 86 5e-16
gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3... 86 5e-16
gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4... 86 5e-16
gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2... 86 5e-16
>gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo
sapiens]
Length = 2261
Score = 4548 bits (11796), Expect = 0.0
Identities = 2261/2261 (100%), Positives = 2261/2261 (100%)
Query: 1 MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKA 60
MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKA
Sbjct: 1 MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKA 60
Query: 61 MPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVARLFSDARRLLLYSQKDT 120
MPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVARLFSDARRLLLYSQKDT
Sbjct: 61 MPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVARLFSDARRLLLYSQKDT 120
Query: 121 SMKDMRKVLRTLQQIKKSSSNLKLQDFLVDNETFSGFLYHNLSLPKSTVDKMLRADVILH 180
SMKDMRKVLRTLQQIKKSSSNLKLQDFLVDNETFSGFLYHNLSLPKSTVDKMLRADVILH
Sbjct: 121 SMKDMRKVLRTLQQIKKSSSNLKLQDFLVDNETFSGFLYHNLSLPKSTVDKMLRADVILH 180
Query: 181 KVFLQGYQLHLTSLCNGSKSEEMIQLGDQEVSELCGLPREKLAAAERVLRSNMDILKPIL 240
KVFLQGYQLHLTSLCNGSKSEEMIQLGDQEVSELCGLPREKLAAAERVLRSNMDILKPIL
Sbjct: 181 KVFLQGYQLHLTSLCNGSKSEEMIQLGDQEVSELCGLPREKLAAAERVLRSNMDILKPIL 240
Query: 241 RTLNSTSPFPSKELAEATKTLLHSLGTLAQELFSMRSWSDMRQEVMFLTNVNSSSSSTQI 300
RTLNSTSPFPSKELAEATKTLLHSLGTLAQELFSMRSWSDMRQEVMFLTNVNSSSSSTQI
Sbjct: 241 RTLNSTSPFPSKELAEATKTLLHSLGTLAQELFSMRSWSDMRQEVMFLTNVNSSSSSTQI 300
Query: 301 YQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNGTEEDAETFYDNSTTPYCNDLMK 360
YQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNGTEEDAETFYDNSTTPYCNDLMK
Sbjct: 301 YQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNGTEEDAETFYDNSTTPYCNDLMK 360
Query: 361 NLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELS 420
NLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELS
Sbjct: 361 NLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELS 420
Query: 421 PKIWTFMENSQEMDLVRMLLDSRDNDHFWEQQLDGLDWTAQDIVAFLAKHPEDVQSSNGS 480
PKIWTFMENSQEMDLVRMLLDSRDNDHFWEQQLDGLDWTAQDIVAFLAKHPEDVQSSNGS
Sbjct: 421 PKIWTFMENSQEMDLVRMLLDSRDNDHFWEQQLDGLDWTAQDIVAFLAKHPEDVQSSNGS 480
Query: 481 VYTWREAFNETNQAIRTISRFMECVNLNKLEPIATEVWLINKSMELLDERKFWAGIVFTG 540
VYTWREAFNETNQAIRTISRFMECVNLNKLEPIATEVWLINKSMELLDERKFWAGIVFTG
Sbjct: 481 VYTWREAFNETNQAIRTISRFMECVNLNKLEPIATEVWLINKSMELLDERKFWAGIVFTG 540
Query: 541 ITPGSIELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVV 600
ITPGSIELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVV
Sbjct: 541 ITPGSIELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVV 600
Query: 601 EQAIIRVLTGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIV 660
EQAIIRVLTGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIV
Sbjct: 601 EQAIIRVLTGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIV 660
Query: 661 YEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFV 720
YEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFV
Sbjct: 661 YEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFV 720
Query: 721 FLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFTLKIFAS 780
FLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFTLKIFAS
Sbjct: 721 FLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFTLKIFAS 780
Query: 781 LLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGVMTW 840
LLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGVMTW
Sbjct: 781 LLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGVMTW 840
Query: 841 YIEAVFPGQYGIPRPWYFPCTKSYWFGEESDEKSHPGSNQKRISEICMEEEPTHLKLGVS 900
YIEAVFPGQYGIPRPWYFPCTKSYWFGEESDEKSHPGSNQKRISEICMEEEPTHLKLGVS
Sbjct: 841 YIEAVFPGQYGIPRPWYFPCTKSYWFGEESDEKSHPGSNQKRISEICMEEEPTHLKLGVS 900
Query: 901 IQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYIL 960
IQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYIL
Sbjct: 901 IQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYIL 960
Query: 961 GKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVG 1020
GKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVG
Sbjct: 961 GKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVG 1020
Query: 1021 LPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQ 1080
LPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQ
Sbjct: 1021 LPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQ 1080
Query: 1081 GRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLS 1140
GRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLS
Sbjct: 1081 GRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLS 1140
Query: 1141 SCRNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDI 1200
SCRNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDI
Sbjct: 1141 SCRNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDI 1200
Query: 1201 GHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAE 1260
GHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAE
Sbjct: 1201 GHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAE 1260
Query: 1261 TSDGTLPARRNRRAFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVK 1320
TSDGTLPARRNRRAFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVK
Sbjct: 1261 TSDGTLPARRNRRAFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVK 1320
Query: 1321 GWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQ 1380
GWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQ
Sbjct: 1321 GWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQ 1380
Query: 1381 PWMYNEQYTFVSNDAPEDTGTLELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAP 1440
PWMYNEQYTFVSNDAPEDTGTLELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAP
Sbjct: 1381 PWMYNEQYTFVSNDAPEDTGTLELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAP 1440
Query: 1441 VPQTIMDLFQNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDL 1500
VPQTIMDLFQNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDL
Sbjct: 1441 VPQTIMDLFQNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDL 1500
Query: 1501 TGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDAIKQMKK 1560
TGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDAIKQMKK
Sbjct: 1501 TGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDAIKQMKK 1560
Query: 1561 HLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQK 1620
HLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQK
Sbjct: 1561 HLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQK 1620
Query: 1621 GENPSHYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQER 1680
GENPSHYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQER
Sbjct: 1621 GENPSHYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQER 1680
Query: 1681 VSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLAL 1740
VSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLAL
Sbjct: 1681 VSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLAL 1740
Query: 1741 LLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTDNKLNNIN 1800
LLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTDNKLNNIN
Sbjct: 1741 LLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTDNKLNNIN 1800
Query: 1801 DILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEG 1860
DILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEG
Sbjct: 1801 DILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEG 1860
Query: 1861 VVFFLITVLIQYRFFIRPRPVNAKLSPLNDEDEDVRRERQRILDGGGQNDILEIKELTKI 1920
VVFFLITVLIQYRFFIRPRPVNAKLSPLNDEDEDVRRERQRILDGGGQNDILEIKELTKI
Sbjct: 1861 VVFFLITVLIQYRFFIRPRPVNAKLSPLNDEDEDVRRERQRILDGGGQNDILEIKELTKI 1920
Query: 1921 YRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSN 1980
YRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSN
Sbjct: 1921 YRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSN 1980
Query: 1981 IHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEK 2040
IHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEK
Sbjct: 1981 IHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEK 2040
Query: 2041 YAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLT 2100
YAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLT
Sbjct: 2041 YAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLT 2100
Query: 2101 SHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFG 2160
SHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFG
Sbjct: 2101 SHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFG 2160
Query: 2161 LAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNF 2220
LAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNF
Sbjct: 2161 LAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNF 2220
Query: 2221 AKDQSDDDHLKDLSLHKNQTVVDVAVLTSFLQDEKVKESYV 2261
AKDQSDDDHLKDLSLHKNQTVVDVAVLTSFLQDEKVKESYV
Sbjct: 2221 AKDQSDDDHLKDLSLHKNQTVVDVAVLTSFLQDEKVKESYV 2261
>gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo
sapiens]
Length = 2273
Score = 2239 bits (5802), Expect = 0.0
Identities = 1151/2276 (50%), Positives = 1515/2276 (66%), Gaps = 65/2276 (2%)
Query: 6 QLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAG 65
Q++LLLWKN T R+RQ + ++E+ WPL +FL+LI +R + P Y HECHFPNKAMPSAG
Sbjct: 6 QIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRNANPLYSHHECHFPNKAMPSAG 65
Query: 66 TLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVARLFSDARRLLLYSQKDTSMKDM 125
LPW+QGI CN NNPCF+ PTPGE+PG+V N+N SI+AR++ D + LL+ + + + +
Sbjct: 66 MLPWLQGIFCNVNNPCFQSPTPGESPGIVSNYNNSILARVYRDFQELLMNAPESQHLGRI 125
Query: 126 RKVLRTLQQI---------KKSSSNLKLQDFLVDNETFSGFLYHNLSLPKSTVDKMLRAD 176
L L Q + + ++++D L D ET + FL N+ L S V ++ +
Sbjct: 126 WTELHILSQFMDTLRTHPERIAGRGIRIRDILKDEETLTLFLIKNIGLSDSVVYLLINSQ 185
Query: 177 VILHKVFLQGYQLHLTSL-CNGSKSEEMIQLGDQEVSE-----LCGLPREKLAAAERVLR 230
V + L L + C+ + E I + ++ LC L + L E L
Sbjct: 186 VRPEQFAHGVPDLALKDIACSEALLERFIIFSQRRGAKTVRYALCSLSQGTLQWIEDTLY 245
Query: 231 SNMDILKPILRTLNSTSPFPSKEL-AEATKTLLHSLGTLAQELFSMRSWSDMRQEVMFLT 289
+N+D K + R L + S+ + + +L + QE S D+ L
Sbjct: 246 ANVDFFK-LFRVLPTLLDSRSQGINLRSWGGILSDMSPRIQEFIHRPSMQDLLWVTRPLM 304
Query: 290 NVNSSSSSTQIYQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNGTEEDAETFYDN 349
+ T++ +S ++CG+PEGGG ++ S NWYEDNNYKA G + T +D YD
Sbjct: 305 QNGGPETFTKLMGILSDLLCGYPEGGGSRVLSFNWYEDNNYKAFLGIDSTRKDPIYSYDR 364
Query: 350 STTPYCNDLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVF 409
TT +CN L+++LES+PL++I W+A KPLL+GKILYTPD+PA R+++ N TF+EL
Sbjct: 365 RTTSFCNALIQSLESNPLTKIAWRAAKPLLMGKILYTPDSPAARRILKNANSTFEELEHV 424
Query: 410 HDLEGMWEELSPKIWTFMENSQEMDLVRMLLDSRDNDHFWEQQLDGLDWTAQDIVAFLAK 469
L WEE+ P+IW F +NS +M+++R L + F +QL TA+ I+ FL K
Sbjct: 425 RKLVKAWEEVGPQIWYFFDNSTQMNMIRDTLGNPTVKDFLNRQLGEEGITAEAILNFLYK 484
Query: 470 HPEDVQSSNGSVYTWREAFNETNQAIRTISRFMECVNLNKLEPIATEVWLINKSMELLDE 529
P + Q+ + + + WR+ FN T++ +R +++++EC+ L+K E E L +++ LL+E
Sbjct: 485 GPRESQADDMANFDWRDIFNITDRTLRLVNQYLECLVLDKFESYNDETQLTQRALSLLEE 544
Query: 530 RKFWAGIVFTGITPGSIELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYV 589
FWAG+VF + P + LP HVKYKIRMDID VE+TNKIKD YWD GPRADP ED RY+
Sbjct: 545 NMFWAGVVFPDMYPWTSSLPPHVKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYI 604
Query: 590 WGGFAYLQDVVEQAIIRVLTGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWI 649
WGGFAYLQD+VEQ I R E G+Y+QQMPYPC+VDD F+ +++R P+FM LAWI
Sbjct: 605 WGGFAYLQDMVEQGITRSQVQAEAPVGIYLQQMPYPCFVDDSFMIILNRCFPIFMVLAWI 664
Query: 650 YSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLGNL 709
YSV++ +K IV EKE RLKET++ G+ N+++W +WF+ S + +S LL + + G +
Sbjct: 665 YSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHGRI 724
Query: 710 LPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQD 769
L YSDP ++F+FL F+ TI+ CFL+ST FS+A+LAAAC G+IYFTLYLP++LC AWQD
Sbjct: 725 LHYSDPFILFLFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPHILCFAWQD 784
Query: 770 YVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMML 829
+ LK SLLSPVAFGFG EY FEEQG+G+QW N+ SP E D F+ S+ MML
Sbjct: 785 RMTAELKKAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSMQMML 844
Query: 830 FDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFG-------------------EES 870
D +YG++ WY++ VFPG YG P PWYF +SYW G EE+
Sbjct: 845 LDAAVYGLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPLTEET 904
Query: 871 DEKSHPGSNQKRISEICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITS 930
++ HP + I + E E GV ++NLVK++ + AVD L + FYE QIT+
Sbjct: 905 EDPEHP----EGIHDSFFEREHPGWVPGVCVKNLVKIFEPCGRPAVDRLNITFYENQITA 960
Query: 931 FLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTV 990
FLGHNGAGKTTT+SILTGL PPTSGT + G+DI + + +RQ+LG+CPQHN+LF LTV
Sbjct: 961 FLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGMCPQHNILFHHLTV 1020
Query: 991 EEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVGG 1050
EH+ FYA+LKG S++ + EME M D GL K + LSGGMQRKLSVA+AFVG
Sbjct: 1021 AEHMLFYAQLKGKSQEEAQLEMEAMLEDTGL-HHKRNEEAQDLSGGMQRKLSVAIAFVGD 1079
Query: 1051 SKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDRIAIISHGKLC 1110
+KVVILDEPT+GVDPYSRR IW+LLLKYR GRTII+STHHMDEAD+LGDRIAII+ G+L
Sbjct: 1080 AKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLY 1139
Query: 1111 CVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSSSDAGLGSD 1170
C G+ LFLKN GTG YLTLV+K +++ S + S T S K S ++ A +
Sbjct: 1140 CSGTPLFLKNCFGTGLYLTLVRK-MKNIQSQRKGSEGTCSCSSKGFS---TTCPAHVDDL 1195
Query: 1171 HESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLS 1230
L DV+ + +++ HV EA+LVE IG EL ++LP + K A+ LF E+++ L+
Sbjct: 1196 TPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLA 1255
Query: 1231 DLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQSCLRPFTEDDA 1290
DLG+SS+GIS+T LEEIFLKV E+S + G A++ R + CL P E
Sbjct: 1256 DLGLSSFGISDTPLEEIFLKVTEDSDSGPLFAGG---AQQKRENVNPRHPCLGP-REKAG 1311
Query: 1291 ADPNDSDIDPESRETDLLSGM-----DGKGSYQVKGWKLTQQQFVALLWKRLLIARRSRK 1345
P DS++ G + G G +L Q ALL KR RS K
Sbjct: 1312 QTPQDSNVCSPGAPAAHPEGQPPPEPECPGPQLNTGTQLVLQHVQALLVKRFQHTIRSHK 1371
Query: 1346 GFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDTGTLELL 1405
F AQIVLPA FV +AL+ S+++PPFG+YP+L L PW+Y +QYTF S D P L
Sbjct: 1372 DFLAQIVLPATFVFLALMLSIVIPPFGEYPALTLHPWIYGQQYTFFSMDEPGSEQFTVLA 1431
Query: 1406 NALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAPVPQTIMDLFQNGNWTMQNPSPACQC 1465
+ L PGFG RC++ +P+ PC W T V I LFQ WT NPSP+C+C
Sbjct: 1432 DVLLNKPGFGNRCLKEGWLPEYPC-GNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRC 1490
Query: 1466 SSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDLTGRNISDYLVKTYVQIIAKSLKNKI 1525
S+ + MLP CP GAGGLPPPQR Q + +ILQDLT RNISD+LVKTY +I SLK+K
Sbjct: 1491 STREKLTMLPECPEGAGGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKF 1550
Query: 1526 WVNEFRYGGFSLGVSNTQALPPSQEVNDAIKQMKKHLKLAKDSSADRFLNSLGRFMTGLD 1585
WVNE RYGG S+G + + + + + + ++ + F+ L+
Sbjct: 1551 WVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGGPITREASKEIPDFLKHLE 1610
Query: 1586 TKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSHYGITAFNHPLNLTKQQLSE 1645
T++N+KVWFNNKGWHA+ SFLNV +NAILRA+L K +P YGIT + PLNLTK+QLSE
Sbjct: 1611 TEDNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSE 1670
Query: 1646 VALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVW 1705
+ ++TTSVD +V+ICVIF+MSFVPASFV++LIQERV+K+KHLQFISGV P YW++NF+W
Sbjct: 1671 ITVLTTSVDAVVAICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLW 1730
Query: 1706 DMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPST 1765
D+ NY V A LV+ IFI FQ+K+Y S NLP L LLLLYGW++ P+MYPASF+F +PST
Sbjct: 1731 DIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPST 1790
Query: 1766 AYVVLTSVNLFIGINGSVATFVLELFTDNK-LNNINDILKSVFLIFPHFCLGRGLIDMVK 1824
AYV L+ NLFIGIN S TF+LELF +N+ L N +L+ + ++FPHFCLGRGLID+
Sbjct: 1791 AYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLAL 1850
Query: 1825 NQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVNAK 1884
+QA+ D RFGE +P WDL+G+NLFAM VEGVV+FL+T+L+Q FF+
Sbjct: 1851 SQAVTDVYARFGEEHSANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFFLSQWIAEPT 1910
Query: 1885 LSPLNDEDEDVRRERQRILDGGGQNDILEIKELTKIYRRKRKPAVDRICVGIPPGECFGL 1944
P+ DED+DV ERQRI+ GG + DIL + ELTKIY PAVDR+CVG+ PGECFGL
Sbjct: 1911 KEPIVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSSPAVDRLCVGVRPGECFGL 1970
Query: 1945 LGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGR 2004
LGVNGAGK++TFKMLTGDTTVT GDA + SIL+NI EVHQNMGYCPQFDAI ELLTGR
Sbjct: 1971 LGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGR 2030
Query: 2005 EHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPP 2064
EH+ +A LRGVP +E+ KV W+I+ LGL Y + AG YSGGNKRKLSTA+ALIG PP
Sbjct: 2031 EHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPP 2090
Query: 2065 VVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRC 2124
+V LDEPTTGMDP+ARR LWN +S+++EGR+VVLTSHSMEECEALCTR+AIMV G FRC
Sbjct: 2091 LVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRC 2150
Query: 2125 LGSVQHLKNRFGDGYTIVVRIAGSN----PDLKPVQDFFGLAFPGSVLKEKHRNMLQYQL 2180
+G++QHLK++FGDGY + ++I PDL PV+ FF FPGSV +E+H NMLQ+Q+
Sbjct: 2151 MGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQV 2210
Query: 2181 PSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDLSLH 2236
S SSLARIF +L K L IE+YSV+QTTLDQVFVNFAK Q++ DL LH
Sbjct: 2211 SS--SSLARIFQLLLSHKDSLLIEEYSVTQTTLDQVFVNFAKQQTES---HDLPLH 2261
>gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo
sapiens]
Length = 2146
Score = 2052 bits (5317), Expect = 0.0
Identities = 1052/2008 (52%), Positives = 1386/2008 (69%), Gaps = 62/2008 (3%)
Query: 234 DILKPILRTLNSTSPFPSKELAEATKTLLHSLGTLAQELFSMRSWSDMRQEVMFLTNVNS 293
++L +LRT + + E +LL + LAQEL ++RS ++R L
Sbjct: 158 ELLTSLLRT--ESLGLALGQAQEPLHSLLEAAEDLAQELLALRSLVELRA---LLQRPRG 212
Query: 294 SSSSTQIYQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNGTEEDAETFYDNSTTP 353
+S ++ +S +C SLNWYE ++ L G +E D+S +P
Sbjct: 213 TSGPLEL---LSEALCSVRGPSSTVGPSLNWYEASDLMELVG----QEPESALPDSSLSP 265
Query: 354 YCNDLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLE 413
C++L+ L+S PLSR++W+ LKPL++GK+L+ PDTP TR++MA+VN+TF+EL + D+
Sbjct: 266 ACSELIGALDSHPLSRLLWRRLKPLILGKLLFAPDTPFTRKLMAQVNRTFEELTLLRDVR 325
Query: 414 GMWEELSPKIWTFMENSQEMDLVRMLLDSRDNDHFWEQQLDGLDWTAQDIVAFLAKHPED 473
+WE L P+I+TFM +S + +++ LL +D Q G + + +FL
Sbjct: 326 EVWEMLGPRIFTFMNDSSNVAMLQRLLQMQDEGR--RQPRPGGRDHMEALRSFLDP---- 379
Query: 474 VQSSNGSVYTWREAFNETNQAIRTISRFMECVNLNKLEPIATEVWLINKSMELLDERKFW 533
S G Y+W++A + + T+ R EC++L+KLE +E L++++++LL E +FW
Sbjct: 380 --GSGG--YSWQDAHADVGHLVGTLGRVTECLSLDKLEAAPSEAALVSRALQLLAEHRFW 435
Query: 534 AGIVFTGITPGSIELPH--------HVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFED 585
AG+VF G S H HV+ KIRMDID V RTNKI+D +WDPGP ADP D
Sbjct: 436 AGVVFLGPEDSSDPTEHPTPDLGPGHVRIKIRMDIDVVTRTNKIRDRFWDPGPAADPLTD 495
Query: 586 MRYVWGGFAYLQDVVEQAIIRVLTGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMT 645
+RYVWGGF YLQD+VE+A +RVL+G + G+Y+QQMPYPCYVDD+FLRV+SRS+PLF+T
Sbjct: 496 LRYVWGGFVYLQDLVERAAVRVLSGANPRAGLYLQQMPYPCYVDDVFLRVLSRSLPLFLT 555
Query: 646 LAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILK 705
LAWIYSV + +K +V EKE RL++TMR MGL ++LW WF+S L P L+SA LLV++LK
Sbjct: 556 LAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLK 615
Query: 706 LGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCV 765
LG++LPYS P VVF+FL+ FAV T+ Q FL+S FSRANLAAACGG+ YF+LYLPYVLCV
Sbjct: 616 LGDILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCV 675
Query: 766 AWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSV 825
AW+D + ++ ASLLSPVAFGFGCE AL EEQG G QW N+ P D F+L
Sbjct: 676 AWRDRLPAGGRVAASLLSPVAFGFGCESLALLEEQGEGAQWHNVGTRPTA-DVFSLAQVS 734
Query: 826 SMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEESDEKSHPGSNQKRISE 885
++L D LYG+ TWY+EAV PGQYGIP PW FP +SYW G + P +
Sbjct: 735 GLLLLDAALYGLATWYLEAVCPGQYGIPEPWNFPFRRSYWCGPRPPKSPAPCPTPLD-PK 793
Query: 886 ICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSI 945
+ +EE P L GVS+++L K + + A+ GL+L+FY+G IT+FLGHNGAGKTTT+SI
Sbjct: 794 VLVEEAPPGLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSI 853
Query: 946 LTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSE 1005
L+GLFPP+ G+A+ILG D+RS M+ IR +LGVCPQ+NVLFDMLTV+EH+WFY RLKGLS
Sbjct: 854 LSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSA 913
Query: 1006 KHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDP 1065
V E +++ DVGL S K +T LSGGMQRKLSVA+AFVGGS+VVILDEPTAGVDP
Sbjct: 914 AVVGPEQDRLLQDVGLVS-KQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDP 972
Query: 1066 YSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTG 1125
SRRGIWELLLKYR+GRT+ILSTHH+DEA++LGDR+A+++ G+LCC GS LFL+ LG+G
Sbjct: 973 ASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSG 1032
Query: 1126 YYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISN 1185
YYLTLVK + + + +K D+ + S D + S + +
Sbjct: 1033 YYLTLVKARLPLTTN------------EKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLA 1080
Query: 1186 LIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLE 1245
L++ V ARLVE++ HEL VLPY A +G+F LF E+D RL++L ++ YGIS+T+LE
Sbjct: 1081 LVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLE 1140
Query: 1246 EIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQSCLRPFTEDDAADPNDSDIDPESRET 1305
EIFLKV EE D + DG+ G + + A N + ET
Sbjct: 1141 EIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAG-SAPET 1199
Query: 1306 DLLSGMDGKGSYQVKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFS 1365
D SG D G +V+GW LT+QQ ALL KR L+ARRSR+G FAQIVLPA+FV +ALVFS
Sbjct: 1200 DQGSGPDAVG--RVQGWALTRQQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFS 1257
Query: 1366 LIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDTGTLELLNALTKDPGFGTRCMEGNPIP 1425
LIVPPFG YP+L L P MY Q +F S DAP D G LL AL ++ G +
Sbjct: 1258 LIVPPFGHYPALRLSPTMYGAQVSFFSEDAPGDPGRARLLEALLQEAG----------LE 1307
Query: 1426 DTPCQAGEEEWTTAPVPQTIMDLFQNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLP 1485
+ P Q ++ VP + + +GNWT ++PSPACQCS +++LP CP AGG P
Sbjct: 1308 EPPVQHSSHRFSAPEVPAEVAKVLASGNWTPESPSPACQCSRPGARRLLPDCPAAAGGPP 1367
Query: 1486 PPQRKQNTADILQDLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQAL 1545
PPQ + +++Q+LTGRN+SD+LVKTY +++ + LK K WVNE RYGGFSLG L
Sbjct: 1368 PPQAVTGSGEVVQNLTGRNLSDFLVKTYPRLVRQGLKTKKWVNEVRYGGFSLG-GRDPGL 1426
Query: 1546 PPSQEVNDAIKQMKKHLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVWFNNKGWHAISSF 1605
P QE+ +++++ L + DR L +L + LD ++++K+WFNNKGWH++ +F
Sbjct: 1427 PSGQELGRSVEELWALLSPLPGGALDRVLKNLTAWAHSLDAQDSLKIWFNNKGWHSMVAF 1486
Query: 1606 LNVINNAILRANLQKGENPSHYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAM 1665
+N +NAILRA+L G + IT NHPLNLTK+QLSE ALM +SVDVLVSICV+FAM
Sbjct: 1487 VNRASNAILRAHLPPGPARHAHSITTLNHPLNLTKEQLSEGALMASSVDVLVSICVVFAM 1546
Query: 1666 SFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQ 1725
SFVPASF + LI+ERV++AKHLQ + G+ P +YWL NF+WDMCNY+VPA +V++IF+ FQ
Sbjct: 1547 SFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLIFLAFQ 1606
Query: 1726 QKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVAT 1785
Q++YV+ NLP L LLLLLYGWSITPLMYPASF F +PSTAYVVLT +NLFIGINGS+AT
Sbjct: 1607 QRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMAT 1666
Query: 1786 FVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLS 1845
FVLELF+D KL ++ ILK VFLIFPHFCLGRGLIDMV+NQAMADA ER G+ +F SPL
Sbjct: 1667 FVLELFSDQKLQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDRQFQSPLR 1726
Query: 1846 WDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVNAKLSPLNDEDEDVRRERQRILDG 1905
W++VG+NL AM ++G +F L T+L+Q+R + P+P L L +EDEDV RER+R++ G
Sbjct: 1727 WEVVGKNLLAMVIQGPLFLLFTLLLQHRSQLLPQPRVRSLPLLGEEDEDVARERERVVQG 1786
Query: 1906 GGQNDILEIKELTKIYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTV 1965
Q D+L ++ LTK+YR +R PAVDR+C+GIPPGECFGLLGVNGAGK+STF+M+TGDT
Sbjct: 1787 ATQGDVLVLRNLTKVYRGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLA 1846
Query: 1966 TRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVG 2025
+RG+A L +S+ H +MGYCPQ DAI ELLTGREH+E A LRGVPE +V +
Sbjct: 1847 SRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTA 1906
Query: 2026 EWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWN 2085
+ +LGL Y ++ AG YSGGNKRKL+TA+AL+G P VVFLDEPTTGMDP ARRFLWN
Sbjct: 1907 GSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWN 1966
Query: 2086 CALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRI 2145
L+VV+EGRSV+LTSHSMEECEALC+R+AIMVNGRFRCLGS QHLK RF G+T+ +R+
Sbjct: 1967 SLLAVVREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRV 2026
Query: 2146 AGSNPDLKPVQDFFGLAFPGSVLKEKHRNMLQYQL-PSSLSSLARIFSILSQSKKRLHIE 2204
+ +P F FPG+ L+E H L++QL P +LAR+F L+ +E
Sbjct: 2027 PAARS--QPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVE 2084
Query: 2205 DYSVSQTTLDQVFVNFAKDQSDDDHLKD 2232
D+SVSQT L++VF+ F+KDQ D+ ++
Sbjct: 2085 DFSVSQTMLEEVFLYFSKDQGKDEDTEE 2112
Score = 170 bits (430), Expect = 2e-41
Identities = 76/139 (54%), Positives = 102/139 (73%)
Query: 1 MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKA 60
MA W QL LLLWKN +RRRQ QLL+E+ WPLF+F IL++VR S+PP E HECHFPNK
Sbjct: 1 MAFWTQLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKP 60
Query: 61 MPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVARLFSDARRLLLYSQKDT 120
+PSAGT+PW+QG+ICN NN CF TPGE PG + NFN S+V+RL +DAR +L +
Sbjct: 61 LPSAGTVPWLQGLICNVNNTCFPQLTPGEEPGRLSNFNDSLVSRLLADARTVLGGASAHR 120
Query: 121 SMKDMRKVLRTLQQIKKSS 139
++ + K++ TL+ + ++
Sbjct: 121 TLAGLGKLIATLRAARSTA 139
>gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform a
[Homo sapiens]
Length = 2436
Score = 1514 bits (3920), Expect = 0.0
Identities = 890/2004 (44%), Positives = 1179/2004 (58%), Gaps = 252/2004 (12%)
Query: 382 KILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELSPKIWTFMENSQEMDLVRMLLD 441
KILY P +V+ + N+TF + +W +S +I +F+E + +R L
Sbjct: 459 KILYAPAGSEVDRVILKANETFAFVGNVTHYAQVWLNISAEIRSFLEQGRLQQHLRWL-- 516
Query: 442 SRDNDHFWEQQLDGLDWTAQDIVAFLAKHPEDVQSSNGSVYTWREAFNETN--------- 492
Q VA L HPE + N S+ A + N
Sbjct: 517 -------------------QQYVAELRLHPEAL---NLSLDELPPALRQDNFSLPSGMAL 554
Query: 493 -QAIRTIS-------RFMECVNLNKLEPIATEVWLINKSMELL--DERKFWAGIVFTGIT 542
Q + TI +FM V+++ + E ++N ++ D +A ++F
Sbjct: 555 LQQLDTIDNAACGWIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRK 614
Query: 543 PGSIELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQ 602
GS LP HV YKIR + E+TN+I+ YW PGP Y GF ++QD++E+
Sbjct: 615 DGS--LPPHVHYKIRQNSSFTEKTNEIRRAYWRPGPNTG---GRFYFLYGFVWIQDMMER 669
Query: 603 AIIRVLTGTEK-KTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIVY 661
AII G + + G Y+Q PYPCY D FL V+ MPL M ++W+YSVA+ I+ IV
Sbjct: 670 AIIDTFVGHDVVEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVA 729
Query: 662 EKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFVF 721
EKE RLKE M+ MGL+N++ W +WFI+ + L +S L ILK G +L +S ++++F
Sbjct: 730 EKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLF 789
Query: 722 LSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQ----DYVGFTLKI 777
L+V+AV TI+ CFL+S L+S+A LA+ACGGIIYF Y+PY+ + D + K
Sbjct: 790 LAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKC 849
Query: 778 FASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGV 837
ASL+S AFG G +YFAL+E G+G+QW +SPVE D FNL +V+M++ D +YG+
Sbjct: 850 IASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGI 909
Query: 838 MTWYIEAVFPGQYGIPRPWYFPCTKSYWFGE---ESDEKSHPGSNQKRIS-----EIC-- 887
+TWYIEAV PG YG+PRPWYFP KSYW G E+ E S P + R+S + C
Sbjct: 910 LTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAM 969
Query: 888 ----------MEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGA 937
MEEEPTHL L V + L KVY+D K+A++ L+LN YE Q+ SFLGHNGA
Sbjct: 970 ESRRFEETRGMEEEPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGA 1029
Query: 938 GKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFY 997
GKTTTMSILTGLFPPTSG+A I G DIR+EM IR+NLG+CPQHNVLFD LTVEEH+WFY
Sbjct: 1030 GKTTTMSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFY 1089
Query: 998 ARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILD 1057
+RLK ++++ ++ EM++M D+ L S+K S LSGGM+RKLSVA+AFVGGS+ +ILD
Sbjct: 1090 SRLKSMAQEEIRREMDKMIEDLEL-SNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILD 1148
Query: 1058 EPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLF 1117
EPTAGVDPY+RR IW+L+LKY+ GRTI+LSTHHMDEAD+LGDRIAIISHGKL C GS LF
Sbjct: 1149 EPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLF 1208
Query: 1118 LKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLT 1177
LK G GY LTLVK+ E ++ S A L S E
Sbjct: 1209 LKGTYGDGYRLTLVKRPAEPGGP------------QEPGLASSPPGRAPLSSCSELQ--- 1253
Query: 1178 IDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSY 1237
+S IRKHV+ LV D EL+Y+LP EAAK+GAF LF ++ L L +SS+
Sbjct: 1254 -----VSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSF 1308
Query: 1238 GISETTLEEIFLKVAEE------SGVDAETSDGTLPARRNRRAFGD-------------- 1277
G+ +TTLEE+FLKV+EE S D + S + A G+
Sbjct: 1309 GLMDTTLEEVFLKVSEEDQSLENSEADVKESRKDVLPGAEGPASGEGHAGNLARCSELTQ 1368
Query: 1278 KQSCLRPFTEDDAA--------------------DPNDSD-IDPESRETDLLSGMDGKGS 1316
Q+ L+ + +A +P D D + + E + LS + G+GS
Sbjct: 1369 SQASLQSASSVGSARGDEGAGYTDVYGDYRPLFDNPQDPDNVSLQEVEAEALSRV-GQGS 1427
Query: 1317 YQVKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPS 1376
++ G L +QF LL KR ARR+ K F+QI+LPA FVC+A+ +L VP G P
Sbjct: 1428 RKLDGGWLKVRQFHGLLVKRFHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPP 1487
Query: 1377 LELQPWMYNEQYTFVSNDAP--------------EDTGTLELLNALTKDPGFGTRCMEGN 1422
L L P Y+ N P D +L++ G G C+ +
Sbjct: 1488 LVLSPSQYHNYTQPRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKS 1547
Query: 1423 PI-----PDTPCQAGEEEWTTAPVPQTI-MDLFQNG----NWTMQNPSPA---------- 1462
P P +GE A ++ ++ F G N+ PSPA
Sbjct: 1548 PANGSLGPTLNLSSGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDE 1607
Query: 1463 ---------------------------------CQCSSDKIKKMLPVCPPGAGGLPPPQR 1489
C CS+ CP GG PPQ
Sbjct: 1608 DLQAWNVSLPPTAGPEMWTSAPSLPRLVREPVRCTCSAQGTGFS---CPSSVGG-HPPQM 1663
Query: 1490 KQNTADILQDLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQ 1549
+ T DIL D+TG N+S+YL+ T + RYG + G N P+
Sbjct: 1664 RVVTGDILTDITGHNVSEYLLFTSDRF-----------RLHRYGAITFG--NVLKSIPAS 1710
Query: 1550 EVNDAIKQMKKHLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVI 1609
A ++K + + +V++NNKG+H++ ++LN +
Sbjct: 1711 FGTRAPPMVRK-----------------------IAVRRAAQVFYNNKGYHSMPTYLNSL 1747
Query: 1610 NNAILRANLQKGE-NPSHYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFV 1668
NNAILRANL K + NP+ YGIT NHP+N T LS + + DV+++I +I AMSFV
Sbjct: 1748 NNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLS-LDYLLQGTDVVIAIFIIVAMSFV 1806
Query: 1669 PASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKS 1728
PASFVVFL+ E+ +KAKHLQF+SG P+IYWL+N+VWDM NY+VPAT +II F +
Sbjct: 1807 PASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPA 1866
Query: 1729 YVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVL 1788
Y S TN P + L LLYGWSITP+MYPASF F++PS+AYV L +NLFIGI +VATF+L
Sbjct: 1867 YTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLL 1926
Query: 1789 ELFT-DNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGE-NRFVSPLSW 1846
+LF D L +N LKS FLIFP++ LG GL++M N+ + + + G+ ++ SP W
Sbjct: 1927 QLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPFEW 1986
Query: 1847 DLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVNAKLSPLNDEDEDVRRERQRILDGG 1906
D+V R L AMAVEGVV FL+T++ QY F RP+ + P+ D D DV ERQR+L G
Sbjct: 1987 DIVTRGLVAMAVEGVVGFLLTIMCQYNFLRRPQRMPVSTKPVED-DVDVASERQRVLRGD 2045
Query: 1907 GQNDILEIKELTKIYRRK---RKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDT 1963
ND+++I+ LTK+Y+ + R AVDR+C+G+ PGECFGLLGVNGAGK+STFKMLTGD
Sbjct: 2046 ADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDE 2105
Query: 1964 TVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGK 2023
+ T G+AF+N +S+L + +V Q++GYCPQ DA+ + LT REH++ + LRG+ K+ +
Sbjct: 2106 STTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEAR 2165
Query: 2024 VGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFL 2083
V +WA+ KL L KY +K AG YSGGNKRKLSTA+ALIG P +FLDEPTTGMDPKARRFL
Sbjct: 2166 VVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFL 2225
Query: 2084 WNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVV 2143
WN L ++K GRSVVLTSHSMEECEALCTR+AIMVNGR RCLGS+QHLKNRFGDGY I V
Sbjct: 2226 WNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITV 2285
Query: 2144 RIAGSNPDLKPVQDFFGLAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHI 2203
R S+ +K V FF FP ++LKE+H +QYQL S SLA++FS + Q L I
Sbjct: 2286 R-TKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEQVSGVLGI 2344
Query: 2204 EDYSVSQTTLDQVFVNFAKDQSDD 2227
EDYSVSQTTLD VFVNFAK QSD+
Sbjct: 2345 EDYSVSQTTLDNVFVNFAKKQSDN 2368
Score = 202 bits (513), Expect = 4e-51
Identities = 186/707 (26%), Positives = 307/707 (43%), Gaps = 110/707 (15%)
Query: 630 DIFLRVMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISS 689
D L+ + +F+ +A + A + +V EK + K + G + I W + ++
Sbjct: 1785 DYLLQGTDVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWD 1844
Query: 690 LIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAAC 749
++ LV A V+IL + +L Y+ P+ LS+F +L + I+ + A+
Sbjct: 1845 MLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLF----LLYGWSITPIMYPAS----- 1895
Query: 750 GGIIYFTLYLP---YVLCVAWQDYVGFTLKIFASLLS--------PVAFGFGCEYFALFE 798
F +P YV + ++G T + LL V + F +F
Sbjct: 1896 -----FWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFP 1950
Query: 799 EQGIGVQWDNLFESPVEEDGFNLTTSV-------SMMLFDTFLYGVMTWYIEAV------ 845
+G L E E + S +D G++ +E V
Sbjct: 1951 NYNLG---HGLMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMAVEGVVGFLLT 2007
Query: 846 FPGQYG-IPRPWYFPCTKSYWFGEESDEKSHPGSNQKRISEICMEEEPTHLKLGVSIQNL 904
QY + RP P + + ++ S ++R+ + + V I+NL
Sbjct: 2008 IMCQYNFLRRPQRMPVST-----KPVEDDVDVASERQRVLRGDADNDM------VKIENL 2056
Query: 905 VKVYRD---GMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILG 961
KVY+ G +AVD L L G+ LG NGAGKT+T +LTG T G A++ G
Sbjct: 2057 TKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNG 2116
Query: 962 KDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGL 1021
+ E+ ++Q+LG CPQ + LFD LT EH+ Y RL+G+S K +A + + AL+
Sbjct: 2117 HSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKD-EARVVKWALEKLE 2175
Query: 1022 PSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKY-RQ 1080
+ SGG +RKLS A+A +G + LDEPT G+DP +RR +W L+L +
Sbjct: 2176 LTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKT 2235
Query: 1081 GRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLS 1140
GR+++L++H M+E + L R+AI+ +G+L C+GS LKN+ G GY +T+ K +S
Sbjct: 2236 GRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQS--- 2292
Query: 1141 SCRNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDI 1200
V + ++ EA L E
Sbjct: 2293 ---------------------------------------VKDVVRFFNRNFPEAMLKERH 2313
Query: 1201 GHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAE 1260
++ Y L E + ++F +++ LGI Y +S+TTL+ +F+ A++ + E
Sbjct: 2314 HTKVQYQLKSEHI---SLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFAKKQSDNLE 2370
Query: 1261 TSDGTLPARRNRRAFGDKQSCLRPFTEDD------AADPNDSDIDPE 1301
+ T P + G S LRP + A +P D D + E
Sbjct: 2371 QQE-TEPPSALQSPLGCLLSLLRPRSAPTELRALVADEPEDLDTEDE 2416
Score = 187 bits (474), Expect = 1e-46
Identities = 155/647 (23%), Positives = 288/647 (44%), Gaps = 80/647 (12%)
Query: 1653 VDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVV 1712
++ ++ +C++ + + A + ++ E+ + K + G+ ++W++ F+ +
Sbjct: 704 IEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSI 763
Query: 1713 PATLVIIIF----ICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYV 1768
T + I + + L V A+ +++ + ++ L A Y
Sbjct: 764 SVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYF 823
Query: 1769 VLTSVNLFIGINGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAM 1828
+ +++ I VA +K+ + S+ + F LG + + +
Sbjct: 824 LSYVPYMYVAIREEVA--------HDKITAFEKCIASL-MSTTAFGLGSKYFALYEVAGV 874
Query: 1829 ADALERFGENRFVSPLSWDLVGRNLFA--MAVEGVVFFLITVLIQY---RFFIRPRPVNA 1883
F + SP+ D L + V+ VV+ ++T I+ + PRP
Sbjct: 875 GIQWHTFSQ----SPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPGMYGLPRPWYF 930
Query: 1884 KLSP-------------------------LNDEDEDVRRERQRILDGGGQND-------I 1911
L + +ED+ E +R + G + +
Sbjct: 931 PLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFEETRGMEEEPTHLPLV 990
Query: 1912 LEIKELTKIYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAF 1971
+ + +LTK+Y+ +K A++++ + + + LG NGAGK++T +LTG T G A
Sbjct: 991 VCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSAT 1050
Query: 1972 LNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRK 2031
+ + I + + E+ +N+G CPQ + + + LT EH+ F++ L+ + ++E+ + + I
Sbjct: 1051 IYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIED 1110
Query: 2032 LGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVV 2091
L L SGG KRKLS A+A +GG + LDEPT G+DP ARR +W+ L
Sbjct: 1111 LELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILK-Y 1169
Query: 2092 KEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGY--TIVVR----- 2144
K GR+++L++H M+E + L R+AI+ +G+ +C GS LK +GDGY T+V R
Sbjct: 1170 KPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPG 1229
Query: 2145 ------IAGSNPDLKP--------VQDFFGLAFPGSVLKEKHRNMLQYQLPSSLS---SL 2187
+A S P P V F +L L Y LPS + +
Sbjct: 1230 GPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAF 1289
Query: 2188 ARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFA-KDQSDDDHLKDL 2233
R+F L +S LH+ + + TTL++VF+ + +DQS ++ D+
Sbjct: 1290 ERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADV 1336
Score = 56.6 bits (135), Expect = 3e-07
Identities = 55/192 (28%), Positives = 79/192 (41%), Gaps = 32/192 (16%)
Query: 6 QLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKA-MPSA 64
QL+LLLWKN+T +RR L E+ PL +F IL+ +R P E F A + SA
Sbjct: 6 QLQLLLWKNVTLKRRSPWVLAFEIFIPLVLFFILLGLRQKKPTISVKEVSFYTAAPLTSA 65
Query: 65 GTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVARLFSDARRLL----LYSQKDT 120
G LP +Q + + F + + S V +L R++ L+
Sbjct: 66 GILPVMQSLCPDGQRDEFGFL----------QYANSTVTQLLERLDRVVEEGNLFDPARP 115
Query: 121 SMKDMRKVLRTLQQIKKSSSNLKLQDFLVDNETFSG---------------FLYHNLSLP 165
S+ + LR Q ++ S+ +D T S FL NLSLP
Sbjct: 116 SLGSELEALR--QHLEALSAGPGTSGSHLDRSTVSSFSLDSVARNPQELWRFLTQNLSLP 173
Query: 166 KSTVDKMLRADV 177
ST +L A V
Sbjct: 174 NSTAQALLAARV 185
>gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform b
[Homo sapiens]
Length = 2466
Score = 1514 bits (3920), Expect = 0.0
Identities = 890/2004 (44%), Positives = 1179/2004 (58%), Gaps = 252/2004 (12%)
Query: 382 KILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELSPKIWTFMENSQEMDLVRMLLD 441
KILY P +V+ + N+TF + +W +S +I +F+E + +R L
Sbjct: 489 KILYAPAGSEVDRVILKANETFAFVGNVTHYAQVWLNISAEIRSFLEQGRLQQHLRWL-- 546
Query: 442 SRDNDHFWEQQLDGLDWTAQDIVAFLAKHPEDVQSSNGSVYTWREAFNETN--------- 492
Q VA L HPE + N S+ A + N
Sbjct: 547 -------------------QQYVAELRLHPEAL---NLSLDELPPALRQDNFSLPSGMAL 584
Query: 493 -QAIRTIS-------RFMECVNLNKLEPIATEVWLINKSMELL--DERKFWAGIVFTGIT 542
Q + TI +FM V+++ + E ++N ++ D +A ++F
Sbjct: 585 LQQLDTIDNAACGWIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRK 644
Query: 543 PGSIELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQ 602
GS LP HV YKIR + E+TN+I+ YW PGP Y GF ++QD++E+
Sbjct: 645 DGS--LPPHVHYKIRQNSSFTEKTNEIRRAYWRPGPNTG---GRFYFLYGFVWIQDMMER 699
Query: 603 AIIRVLTGTEK-KTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIVY 661
AII G + + G Y+Q PYPCY D FL V+ MPL M ++W+YSVA+ I+ IV
Sbjct: 700 AIIDTFVGHDVVEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVA 759
Query: 662 EKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFVF 721
EKE RLKE M+ MGL+N++ W +WFI+ + L +S L ILK G +L +S ++++F
Sbjct: 760 EKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLF 819
Query: 722 LSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQ----DYVGFTLKI 777
L+V+AV TI+ CFL+S L+S+A LA+ACGGIIYF Y+PY+ + D + K
Sbjct: 820 LAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKC 879
Query: 778 FASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGV 837
ASL+S AFG G +YFAL+E G+G+QW +SPVE D FNL +V+M++ D +YG+
Sbjct: 880 IASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGI 939
Query: 838 MTWYIEAVFPGQYGIPRPWYFPCTKSYWFGE---ESDEKSHPGSNQKRIS-----EIC-- 887
+TWYIEAV PG YG+PRPWYFP KSYW G E+ E S P + R+S + C
Sbjct: 940 LTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAM 999
Query: 888 ----------MEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGA 937
MEEEPTHL L V + L KVY+D K+A++ L+LN YE Q+ SFLGHNGA
Sbjct: 1000 ESRRFEETRGMEEEPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGA 1059
Query: 938 GKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFY 997
GKTTTMSILTGLFPPTSG+A I G DIR+EM IR+NLG+CPQHNVLFD LTVEEH+WFY
Sbjct: 1060 GKTTTMSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFY 1119
Query: 998 ARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILD 1057
+RLK ++++ ++ EM++M D+ L S+K S LSGGM+RKLSVA+AFVGGS+ +ILD
Sbjct: 1120 SRLKSMAQEEIRREMDKMIEDLEL-SNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILD 1178
Query: 1058 EPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLF 1117
EPTAGVDPY+RR IW+L+LKY+ GRTI+LSTHHMDEAD+LGDRIAIISHGKL C GS LF
Sbjct: 1179 EPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLF 1238
Query: 1118 LKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLT 1177
LK G GY LTLVK+ E ++ S A L S E
Sbjct: 1239 LKGTYGDGYRLTLVKRPAEPGGP------------QEPGLASSPPGRAPLSSCSELQ--- 1283
Query: 1178 IDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSY 1237
+S IRKHV+ LV D EL+Y+LP EAAK+GAF LF ++ L L +SS+
Sbjct: 1284 -----VSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSF 1338
Query: 1238 GISETTLEEIFLKVAEE------SGVDAETSDGTLPARRNRRAFGD-------------- 1277
G+ +TTLEE+FLKV+EE S D + S + A G+
Sbjct: 1339 GLMDTTLEEVFLKVSEEDQSLENSEADVKESRKDVLPGAEGPASGEGHAGNLARCSELTQ 1398
Query: 1278 KQSCLRPFTEDDAA--------------------DPNDSD-IDPESRETDLLSGMDGKGS 1316
Q+ L+ + +A +P D D + + E + LS + G+GS
Sbjct: 1399 SQASLQSASSVGSARGDEGAGYTDVYGDYRPLFDNPQDPDNVSLQEVEAEALSRV-GQGS 1457
Query: 1317 YQVKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPS 1376
++ G L +QF LL KR ARR+ K F+QI+LPA FVC+A+ +L VP G P
Sbjct: 1458 RKLDGGWLKVRQFHGLLVKRFHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPP 1517
Query: 1377 LELQPWMYNEQYTFVSNDAP--------------EDTGTLELLNALTKDPGFGTRCMEGN 1422
L L P Y+ N P D +L++ G G C+ +
Sbjct: 1518 LVLSPSQYHNYTQPRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKS 1577
Query: 1423 PI-----PDTPCQAGEEEWTTAPVPQTI-MDLFQNG----NWTMQNPSPA---------- 1462
P P +GE A ++ ++ F G N+ PSPA
Sbjct: 1578 PANGSLGPTLNLSSGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDE 1637
Query: 1463 ---------------------------------CQCSSDKIKKMLPVCPPGAGGLPPPQR 1489
C CS+ CP GG PPQ
Sbjct: 1638 DLQAWNVSLPPTAGPEMWTSAPSLPRLVREPVRCTCSAQGTGFS---CPSSVGG-HPPQM 1693
Query: 1490 KQNTADILQDLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQ 1549
+ T DIL D+TG N+S+YL+ T + RYG + G N P+
Sbjct: 1694 RVVTGDILTDITGHNVSEYLLFTSDRF-----------RLHRYGAITFG--NVLKSIPAS 1740
Query: 1550 EVNDAIKQMKKHLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVI 1609
A ++K + + +V++NNKG+H++ ++LN +
Sbjct: 1741 FGTRAPPMVRK-----------------------IAVRRAAQVFYNNKGYHSMPTYLNSL 1777
Query: 1610 NNAILRANLQKGE-NPSHYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFV 1668
NNAILRANL K + NP+ YGIT NHP+N T LS + + DV+++I +I AMSFV
Sbjct: 1778 NNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLS-LDYLLQGTDVVIAIFIIVAMSFV 1836
Query: 1669 PASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKS 1728
PASFVVFL+ E+ +KAKHLQF+SG P+IYWL+N+VWDM NY+VPAT +II F +
Sbjct: 1837 PASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPA 1896
Query: 1729 YVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVL 1788
Y S TN P + L LLYGWSITP+MYPASF F++PS+AYV L +NLFIGI +VATF+L
Sbjct: 1897 YTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLL 1956
Query: 1789 ELFT-DNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGE-NRFVSPLSW 1846
+LF D L +N LKS FLIFP++ LG GL++M N+ + + + G+ ++ SP W
Sbjct: 1957 QLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPFEW 2016
Query: 1847 DLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVNAKLSPLNDEDEDVRRERQRILDGG 1906
D+V R L AMAVEGVV FL+T++ QY F RP+ + P+ D D DV ERQR+L G
Sbjct: 2017 DIVTRGLVAMAVEGVVGFLLTIMCQYNFLRRPQRMPVSTKPVED-DVDVASERQRVLRGD 2075
Query: 1907 GQNDILEIKELTKIYRRK---RKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDT 1963
ND+++I+ LTK+Y+ + R AVDR+C+G+ PGECFGLLGVNGAGK+STFKMLTGD
Sbjct: 2076 ADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDE 2135
Query: 1964 TVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGK 2023
+ T G+AF+N +S+L + +V Q++GYCPQ DA+ + LT REH++ + LRG+ K+ +
Sbjct: 2136 STTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEAR 2195
Query: 2024 VGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFL 2083
V +WA+ KL L KY +K AG YSGGNKRKLSTA+ALIG P +FLDEPTTGMDPKARRFL
Sbjct: 2196 VVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFL 2255
Query: 2084 WNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVV 2143
WN L ++K GRSVVLTSHSMEECEALCTR+AIMVNGR RCLGS+QHLKNRFGDGY I V
Sbjct: 2256 WNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITV 2315
Query: 2144 RIAGSNPDLKPVQDFFGLAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHI 2203
R S+ +K V FF FP ++LKE+H +QYQL S SLA++FS + Q L I
Sbjct: 2316 R-TKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEQVSGVLGI 2374
Query: 2204 EDYSVSQTTLDQVFVNFAKDQSDD 2227
EDYSVSQTTLD VFVNFAK QSD+
Sbjct: 2375 EDYSVSQTTLDNVFVNFAKKQSDN 2398
Score = 202 bits (513), Expect = 4e-51
Identities = 186/707 (26%), Positives = 307/707 (43%), Gaps = 110/707 (15%)
Query: 630 DIFLRVMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISS 689
D L+ + +F+ +A + A + +V EK + K + G + I W + ++
Sbjct: 1815 DYLLQGTDVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWD 1874
Query: 690 LIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAAC 749
++ LV A V+IL + +L Y+ P+ LS+F +L + I+ + A+
Sbjct: 1875 MLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLF----LLYGWSITPIMYPAS----- 1925
Query: 750 GGIIYFTLYLP---YVLCVAWQDYVGFTLKIFASLLS--------PVAFGFGCEYFALFE 798
F +P YV + ++G T + LL V + F +F
Sbjct: 1926 -----FWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFP 1980
Query: 799 EQGIGVQWDNLFESPVEEDGFNLTTSV-------SMMLFDTFLYGVMTWYIEAV------ 845
+G L E E + S +D G++ +E V
Sbjct: 1981 NYNLG---HGLMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMAVEGVVGFLLT 2037
Query: 846 FPGQYG-IPRPWYFPCTKSYWFGEESDEKSHPGSNQKRISEICMEEEPTHLKLGVSIQNL 904
QY + RP P + + ++ S ++R+ + + V I+NL
Sbjct: 2038 IMCQYNFLRRPQRMPVST-----KPVEDDVDVASERQRVLRGDADNDM------VKIENL 2086
Query: 905 VKVYRD---GMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILG 961
KVY+ G +AVD L L G+ LG NGAGKT+T +LTG T G A++ G
Sbjct: 2087 TKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNG 2146
Query: 962 KDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGL 1021
+ E+ ++Q+LG CPQ + LFD LT EH+ Y RL+G+S K +A + + AL+
Sbjct: 2147 HSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKD-EARVVKWALEKLE 2205
Query: 1022 PSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKY-RQ 1080
+ SGG +RKLS A+A +G + LDEPT G+DP +RR +W L+L +
Sbjct: 2206 LTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKT 2265
Query: 1081 GRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLS 1140
GR+++L++H M+E + L R+AI+ +G+L C+GS LKN+ G GY +T+ K +S
Sbjct: 2266 GRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQS--- 2322
Query: 1141 SCRNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDI 1200
V + ++ EA L E
Sbjct: 2323 ---------------------------------------VKDVVRFFNRNFPEAMLKERH 2343
Query: 1201 GHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAE 1260
++ Y L E + ++F +++ LGI Y +S+TTL+ +F+ A++ + E
Sbjct: 2344 HTKVQYQLKSEHI---SLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFAKKQSDNLE 2400
Query: 1261 TSDGTLPARRNRRAFGDKQSCLRPFTEDD------AADPNDSDIDPE 1301
+ T P + G S LRP + A +P D D + E
Sbjct: 2401 QQE-TEPPSALQSPLGCLLSLLRPRSAPTELRALVADEPEDLDTEDE 2446
Score = 187 bits (474), Expect = 1e-46
Identities = 155/647 (23%), Positives = 288/647 (44%), Gaps = 80/647 (12%)
Query: 1653 VDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVV 1712
++ ++ +C++ + + A + ++ E+ + K + G+ ++W++ F+ +
Sbjct: 734 IEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSI 793
Query: 1713 PATLVIIIF----ICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYV 1768
T + I + + L V A+ +++ + ++ L A Y
Sbjct: 794 SVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYF 853
Query: 1769 VLTSVNLFIGINGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAM 1828
+ +++ I VA +K+ + S+ + F LG + + +
Sbjct: 854 LSYVPYMYVAIREEVA--------HDKITAFEKCIASL-MSTTAFGLGSKYFALYEVAGV 904
Query: 1829 ADALERFGENRFVSPLSWDLVGRNLFA--MAVEGVVFFLITVLIQY---RFFIRPRPVNA 1883
F + SP+ D L + V+ VV+ ++T I+ + PRP
Sbjct: 905 GIQWHTFSQ----SPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPGMYGLPRPWYF 960
Query: 1884 KLSP-------------------------LNDEDEDVRRERQRILDGGGQND-------I 1911
L + +ED+ E +R + G + +
Sbjct: 961 PLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFEETRGMEEEPTHLPLV 1020
Query: 1912 LEIKELTKIYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAF 1971
+ + +LTK+Y+ +K A++++ + + + LG NGAGK++T +LTG T G A
Sbjct: 1021 VCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSAT 1080
Query: 1972 LNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRK 2031
+ + I + + E+ +N+G CPQ + + + LT EH+ F++ L+ + ++E+ + + I
Sbjct: 1081 IYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIED 1140
Query: 2032 LGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVV 2091
L L SGG KRKLS A+A +GG + LDEPT G+DP ARR +W+ L
Sbjct: 1141 LELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILK-Y 1199
Query: 2092 KEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGY--TIVVR----- 2144
K GR+++L++H M+E + L R+AI+ +G+ +C GS LK +GDGY T+V R
Sbjct: 1200 KPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPG 1259
Query: 2145 ------IAGSNPDLKP--------VQDFFGLAFPGSVLKEKHRNMLQYQLPSSLS---SL 2187
+A S P P V F +L L Y LPS + +
Sbjct: 1260 GPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAF 1319
Query: 2188 ARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFA-KDQSDDDHLKDL 2233
R+F L +S LH+ + + TTL++VF+ + +DQS ++ D+
Sbjct: 1320 ERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADV 1366
>gi|27881501 ATP-binding cassette, sub-family A, member 12 isoform b
[Homo sapiens]
Length = 2277
Score = 1179 bits (3050), Expect = 0.0
Identities = 691/1929 (35%), Positives = 1079/1929 (55%), Gaps = 189/1929 (9%)
Query: 350 STTPYCNDLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVF 409
++TP+C L K++ + P +IW LKP+L+G+ILY P P T+ +M + N T ++LA
Sbjct: 458 NSTPFCFSLYKDIINMPAGPVIWAFLKPMLLGRILYAPYNPVTKAIMEKSNVTLRQLAEL 517
Query: 410 HDLEGMWEELSPKIWTFMENSQEMDLVRMLLDSRDNDHFWEQQLD---GLDWTAQDIVAF 466
+ W + SP FM + ++ +L + + F + + GLD
Sbjct: 518 REKSQEWMDKSP---LFMNSFHLLNQAIPMLQNTLRNPFVQVFVKFSVGLD------AVE 568
Query: 467 LAKHPEDVQSSNGSVYTWREAFNETNQAIRTISRFMECVNLNKLEPIATEVWLINKSMEL 526
L K +++ + + ++ N CV ++++ T + ++ L
Sbjct: 569 LLKQIDELDILRLKLENNIDIIDQLNTLSSLTVNISSCVLYDRIQAAKTIDEMEREAKRL 628
Query: 527 LDERKFWAGIVFT---------GITPGSIELPHHVKYKIRMDIDNVERTNKIKDGYWDPG 577
+ + ++F G G++ LP +KY IRM + + T ++ W PG
Sbjct: 629 YKSNELFGSVIFKLPSNRSWHRGYDSGNVFLPPVIKYTIRMSLKTAQTTRSLRTKIWAPG 688
Query: 578 PRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTG-TEKKTGVYMQQMPYPCYVDDIFLRVM 636
P P + Y F YLQD +E+AII + TG ++ V +Q +PYPC++ D FL +
Sbjct: 689 PHNSPSHNQIY-GRAFIYLQDSIERAIIELQTGRNSQEIAVQVQAIPYPCFMKDNFLTSV 747
Query: 637 SRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVS 696
S S+P+ + +AW+ +A +K +VYEK+ RL E M++MG+++ +F+W I S+ LLV+
Sbjct: 748 SYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVT 807
Query: 697 AGLLVVILKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFT 756
+L++ILK GN+LP ++ ++F++ S ++ I +LIS F+ N+AA G +IY
Sbjct: 808 IVILIIILKFGNILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYII 867
Query: 757 LYLPYVLCVAWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEE 816
+ P+++ V ++ + + LK+F SLLSP AF + +Y A +EEQGIG+QW+N++ SPV++
Sbjct: 868 AFFPFIVLVTVENELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQD 927
Query: 817 DGFNLTTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYW---FG--EESD 871
D + ++L D+F+Y ++ WY+ VFPG YG+ PWYFP SYW FG E
Sbjct: 928 DTTSFGWLCCLILADSFIYFLIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKP 987
Query: 872 EKSH-------------PGSNQKRISEICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDG 918
EKS+ P ++ + + +E EP L +GV++ + K+Y G KVAVD
Sbjct: 988 EKSNGLMFTNIMMQNTNPSASPEYMFSSNIEPEPKDLTVGVALHGVTKIY--GSKVAVDN 1045
Query: 919 LALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVC 978
L LNFYEG ITS LG NGAGKTTT+S+LTGLF ++GT ++ GKDI++++ T+R+N+GVC
Sbjct: 1046 LNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVC 1105
Query: 979 PQHNVLFDMLTVEEHIWFYARLK--GLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGG 1036
QH+VLF LT +EH+ Y +K ++K + E+++ D GL S + K + LSGG
Sbjct: 1106 MQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHK-RVGTLSGG 1164
Query: 1037 MQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADV 1096
M+RKLS+++A +GGS+VVILDEP+ GVDP SRR IW+++ K + RTIILSTHH+DEA+V
Sbjct: 1165 MKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEV 1224
Query: 1097 LGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKED 1156
L DRIA + G L C GS +LK G GY+LTL KK
Sbjct: 1225 LSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKK---------------------- 1262
Query: 1157 SVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAK-E 1215
S + + D A++ +I+ H+ EA L EDIG EL YVLP + K
Sbjct: 1263 ------------SPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVS 1310
Query: 1216 GAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARR--NRR 1273
GA++ L +D+ + DL I YGIS+TT+EE+FL + +ES ++ S L ++ N
Sbjct: 1311 GAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKNSAMSLEHLTQKKIGNSN 1370
Query: 1274 AFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALL 1333
A G T DD + + + D + + +DG G L ++ +A+L
Sbjct: 1371 ANGIS-------TPDDLSVSSSNFTDRDDKILTRGERLDGFG--------LLLKKIMAIL 1415
Query: 1334 WKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMY--NEQYTFV 1391
KR RR+ KG AQ++LP VFV A+ + YP +++ P +Y +EQ F
Sbjct: 1416 IKRFHHTRRNWKGLIAQVILPIVFVTTAMGLGTLRNSSNSYPEIQISPSLYGTSEQTAFY 1475
Query: 1392 SNDAPEDTGTLELLNALTKDPGFGTRCMEGNPIPDTPCQAGE--EEWTTAPVPQTIMDLF 1449
+N P T L++A+ PG C+ + D C + E+W T+ P T +
Sbjct: 1476 ANYHPS---TEALVSAMWDFPGIDNMCLNTS---DLQCLNKDSLEKWNTSGEPITNFGV- 1528
Query: 1450 QNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDLTGRNISDYL 1509
C CS + + CP PP R+ ++ ++ +LTG+ + +YL
Sbjct: 1529 -------------CSCSEN-----VQECPKF--NYSPPHRRTYSSQVIYNLTGQRVENYL 1568
Query: 1510 VKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDAIKQMKKHLKLAKDSS 1569
+ T + + K RYGG+S G L L KD
Sbjct: 1569 ISTANEFVQK-----------RYGGWSFG-----------------------LPLTKDLR 1594
Query: 1570 ADRFLNSLGRFMTGLDTKNNV-KVWFNNKGWHAISSFLNVINNAILRANLQKGENPSHYG 1628
D +TG+ + KVW++ +G+H++ ++LN +NN +LR N+ K + H G
Sbjct: 1595 FD---------ITGVPANRTLAKVWYDPEGYHSLPAYLNSLNNFLLRVNMSKYDAARH-G 1644
Query: 1629 ITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQ 1688
I ++HP + Q E A +++ +D+LV++ ++ S ASFV ++++E +KAK LQ
Sbjct: 1645 IIMYSHPYPGVQDQ--EQATISSLIDILVALSILMGYSVTTASFVTYVVREHQTKAKQLQ 1702
Query: 1689 FISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWS 1748
ISG+ YW++NF++DM Y+VP I I F+ ++ S NL ++LLLLL+G++
Sbjct: 1703 HISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYA 1762
Query: 1749 ITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTDNKLNN-----INDIL 1803
MY + +F A++ VNLF GIN V+ V+ + K N+ I++ L
Sbjct: 1763 TFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETL 1822
Query: 1804 KSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVF 1863
K +FLIFP FC G GLI++ + Q++ D L+ +G + +G A+ +G +F
Sbjct: 1823 KRIFLIFPQFCFGYGLIELSQQQSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMF 1882
Query: 1864 FLITVLIQYRFFIRPRPVNAKLSPLN-----DEDEDVRRERQRILDGGGQNDILEIKELT 1918
F + +LI + R K + + DEDEDVR ER R+ G + D++++ LT
Sbjct: 1883 FSLRLLINESLIKKLRLFFRKFNSSHVRETIDEDEDVRAERLRVESGAAEFDLVQLYCLT 1942
Query: 1919 KIYR--RKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFL-NKN 1975
K Y+ K+ AV+ I +GIP GECFGLLGVNGAGK++ FKMLTGD + G+ + NK
Sbjct: 1943 KTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKT 2002
Query: 1976 SILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLV 2035
L ++ +GYCPQ DA+ +L+T EH+ F+A + G+PEK++ + +R+L L+
Sbjct: 2003 GSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLM 2062
Query: 2036 KYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGR 2095
+ ++ S G KRKLSTA+ALIG P ++ LDEP++GMDPK++R LW V+
Sbjct: 2063 PFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKC 2122
Query: 2096 SVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPV 2155
SV+LTSHSMEECEALCTR+AIMVNG+F+C+GS+QH+K+RFG G+T+ V + + ++ +
Sbjct: 2123 SVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETL 2182
Query: 2156 QDFFGLAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQ 2215
F L FP + LK++H +ML+Y +P + +A IF +L +K L+I ++ VSQTTL++
Sbjct: 2183 TKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALNITNFLVSQTTLEE 2242
Query: 2216 VFVNFAKDQ 2224
VF+NFAKDQ
Sbjct: 2243 VFINFAKDQ 2251
>gi|30795238 ATP-binding cassette, sub-family A, member 12 isoform a
[Homo sapiens]
Length = 2595
Score = 1179 bits (3050), Expect = 0.0
Identities = 691/1929 (35%), Positives = 1079/1929 (55%), Gaps = 189/1929 (9%)
Query: 350 STTPYCNDLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVF 409
++TP+C L K++ + P +IW LKP+L+G+ILY P P T+ +M + N T ++LA
Sbjct: 776 NSTPFCFSLYKDIINMPAGPVIWAFLKPMLLGRILYAPYNPVTKAIMEKSNVTLRQLAEL 835
Query: 410 HDLEGMWEELSPKIWTFMENSQEMDLVRMLLDSRDNDHFWEQQLD---GLDWTAQDIVAF 466
+ W + SP FM + ++ +L + + F + + GLD
Sbjct: 836 REKSQEWMDKSP---LFMNSFHLLNQAIPMLQNTLRNPFVQVFVKFSVGLD------AVE 886
Query: 467 LAKHPEDVQSSNGSVYTWREAFNETNQAIRTISRFMECVNLNKLEPIATEVWLINKSMEL 526
L K +++ + + ++ N CV ++++ T + ++ L
Sbjct: 887 LLKQIDELDILRLKLENNIDIIDQLNTLSSLTVNISSCVLYDRIQAAKTIDEMEREAKRL 946
Query: 527 LDERKFWAGIVFT---------GITPGSIELPHHVKYKIRMDIDNVERTNKIKDGYWDPG 577
+ + ++F G G++ LP +KY IRM + + T ++ W PG
Sbjct: 947 YKSNELFGSVIFKLPSNRSWHRGYDSGNVFLPPVIKYTIRMSLKTAQTTRSLRTKIWAPG 1006
Query: 578 PRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTG-TEKKTGVYMQQMPYPCYVDDIFLRVM 636
P P + Y F YLQD +E+AII + TG ++ V +Q +PYPC++ D FL +
Sbjct: 1007 PHNSPSHNQIY-GRAFIYLQDSIERAIIELQTGRNSQEIAVQVQAIPYPCFMKDNFLTSV 1065
Query: 637 SRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVS 696
S S+P+ + +AW+ +A +K +VYEK+ RL E M++MG+++ +F+W I S+ LLV+
Sbjct: 1066 SYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVT 1125
Query: 697 AGLLVVILKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFT 756
+L++ILK GN+LP ++ ++F++ S ++ I +LIS F+ N+AA G +IY
Sbjct: 1126 IVILIIILKFGNILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYII 1185
Query: 757 LYLPYVLCVAWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEE 816
+ P+++ V ++ + + LK+F SLLSP AF + +Y A +EEQGIG+QW+N++ SPV++
Sbjct: 1186 AFFPFIVLVTVENELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQD 1245
Query: 817 DGFNLTTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYW---FG--EESD 871
D + ++L D+F+Y ++ WY+ VFPG YG+ PWYFP SYW FG E
Sbjct: 1246 DTTSFGWLCCLILADSFIYFLIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKP 1305
Query: 872 EKSH-------------PGSNQKRISEICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDG 918
EKS+ P ++ + + +E EP L +GV++ + K+Y G KVAVD
Sbjct: 1306 EKSNGLMFTNIMMQNTNPSASPEYMFSSNIEPEPKDLTVGVALHGVTKIY--GSKVAVDN 1363
Query: 919 LALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVC 978
L LNFYEG ITS LG NGAGKTTT+S+LTGLF ++GT ++ GKDI++++ T+R+N+GVC
Sbjct: 1364 LNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVC 1423
Query: 979 PQHNVLFDMLTVEEHIWFYARLK--GLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGG 1036
QH+VLF LT +EH+ Y +K ++K + E+++ D GL S + K + LSGG
Sbjct: 1424 MQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHK-RVGTLSGG 1482
Query: 1037 MQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADV 1096
M+RKLS+++A +GGS+VVILDEP+ GVDP SRR IW+++ K + RTIILSTHH+DEA+V
Sbjct: 1483 MKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEV 1542
Query: 1097 LGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKED 1156
L DRIA + G L C GS +LK G GY+LTL KK
Sbjct: 1543 LSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKK---------------------- 1580
Query: 1157 SVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAK-E 1215
S + + D A++ +I+ H+ EA L EDIG EL YVLP + K
Sbjct: 1581 ------------SPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVS 1628
Query: 1216 GAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARR--NRR 1273
GA++ L +D+ + DL I YGIS+TT+EE+FL + +ES ++ S L ++ N
Sbjct: 1629 GAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKNSAMSLEHLTQKKIGNSN 1688
Query: 1274 AFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALL 1333
A G T DD + + + D + + +DG G L ++ +A+L
Sbjct: 1689 ANGIS-------TPDDLSVSSSNFTDRDDKILTRGERLDGFG--------LLLKKIMAIL 1733
Query: 1334 WKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMY--NEQYTFV 1391
KR RR+ KG AQ++LP VFV A+ + YP +++ P +Y +EQ F
Sbjct: 1734 IKRFHHTRRNWKGLIAQVILPIVFVTTAMGLGTLRNSSNSYPEIQISPSLYGTSEQTAFY 1793
Query: 1392 SNDAPEDTGTLELLNALTKDPGFGTRCMEGNPIPDTPCQAGE--EEWTTAPVPQTIMDLF 1449
+N P T L++A+ PG C+ + D C + E+W T+ P T +
Sbjct: 1794 ANYHPS---TEALVSAMWDFPGIDNMCLNTS---DLQCLNKDSLEKWNTSGEPITNFGV- 1846
Query: 1450 QNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDLTGRNISDYL 1509
C CS + + CP PP R+ ++ ++ +LTG+ + +YL
Sbjct: 1847 -------------CSCSEN-----VQECPKF--NYSPPHRRTYSSQVIYNLTGQRVENYL 1886
Query: 1510 VKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDAIKQMKKHLKLAKDSS 1569
+ T + + K RYGG+S G L L KD
Sbjct: 1887 ISTANEFVQK-----------RYGGWSFG-----------------------LPLTKDLR 1912
Query: 1570 ADRFLNSLGRFMTGLDTKNNV-KVWFNNKGWHAISSFLNVINNAILRANLQKGENPSHYG 1628
D +TG+ + KVW++ +G+H++ ++LN +NN +LR N+ K + H G
Sbjct: 1913 FD---------ITGVPANRTLAKVWYDPEGYHSLPAYLNSLNNFLLRVNMSKYDAARH-G 1962
Query: 1629 ITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQ 1688
I ++HP + Q E A +++ +D+LV++ ++ S ASFV ++++E +KAK LQ
Sbjct: 1963 IIMYSHPYPGVQDQ--EQATISSLIDILVALSILMGYSVTTASFVTYVVREHQTKAKQLQ 2020
Query: 1689 FISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWS 1748
ISG+ YW++NF++DM Y+VP I I F+ ++ S NL ++LLLLL+G++
Sbjct: 2021 HISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYA 2080
Query: 1749 ITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTDNKLNN-----INDIL 1803
MY + +F A++ VNLF GIN V+ V+ + K N+ I++ L
Sbjct: 2081 TFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETL 2140
Query: 1804 KSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVF 1863
K +FLIFP FC G GLI++ + Q++ D L+ +G + +G A+ +G +F
Sbjct: 2141 KRIFLIFPQFCFGYGLIELSQQQSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMF 2200
Query: 1864 FLITVLIQYRFFIRPRPVNAKLSPLN-----DEDEDVRRERQRILDGGGQNDILEIKELT 1918
F + +LI + R K + + DEDEDVR ER R+ G + D++++ LT
Sbjct: 2201 FSLRLLINESLIKKLRLFFRKFNSSHVRETIDEDEDVRAERLRVESGAAEFDLVQLYCLT 2260
Query: 1919 KIYR--RKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFL-NKN 1975
K Y+ K+ AV+ I +GIP GECFGLLGVNGAGK++ FKMLTGD + G+ + NK
Sbjct: 2261 KTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKT 2320
Query: 1976 SILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLV 2035
L ++ +GYCPQ DA+ +L+T EH+ F+A + G+PEK++ + +R+L L+
Sbjct: 2321 GSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLM 2380
Query: 2036 KYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGR 2095
+ ++ S G KRKLSTA+ALIG P ++ LDEP++GMDPK++R LW V+
Sbjct: 2381 PFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKC 2440
Query: 2096 SVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPV 2155
SV+LTSHSMEECEALCTR+AIMVNG+F+C+GS+QH+K+RFG G+T+ V + + ++ +
Sbjct: 2441 SVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETL 2500
Query: 2156 QDFFGLAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQ 2215
F L FP + LK++H +ML+Y +P + +A IF +L +K L+I ++ VSQTTL++
Sbjct: 2501 TKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALNITNFLVSQTTLEE 2560
Query: 2216 VFVNFAKDQ 2224
VF+NFAKDQ
Sbjct: 2561 VFINFAKDQ 2569
Score = 63.9 bits (154), Expect = 2e-09
Identities = 26/76 (34%), Positives = 46/76 (60%)
Query: 6 QLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAG 65
QL++L+WKN +RQ L+ + WP+ IF+IL R +PP + C+ + +PS G
Sbjct: 7 QLQILVWKNWLGVKRQPLWTLVLILWPVIIFIILAITRTKFPPTAKPTCYLAPRNLPSTG 66
Query: 66 TLPWVQGIICNANNPC 81
P++Q ++C+ ++ C
Sbjct: 67 FFPFLQTLLCDTDSKC 82
>gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13
[Homo sapiens]
Length = 5058
Score = 1073 bits (2775), Expect = 0.0
Identities = 715/2157 (33%), Positives = 1097/2157 (50%), Gaps = 256/2157 (11%)
Query: 139 SSNLKLQDFLVDNETFSGFLYHNLSLPKSTVDKMLRADVILHKVFLQGYQLHLTSLCNGS 198
+ ++K++D + + + L ++ + T+ +L A++ KV + L+ C+
Sbjct: 3065 TEDVKIKDLMKNITKLTEELRSSIQISNETIHSILEANISHSKVLFSALTVALSGKCDQE 3124
Query: 199 KSEEMIQLGDQEVS-----ELCGLPREKLAAAERVLRSNMDILKPILRTLNSTSPFPSKE 253
++ E S ELC LP K+ + +L N+D+ I +TL P +
Sbjct: 3125 ILHLLLTFPKGEKSWIAAEELCSLPGSKVYSLIVLLSRNLDVRAFIYKTL---MPSEANG 3181
Query: 254 LAEATKTLLHSLGTL---AQELF-------------SMRSWSDMRQEVMFLTNVNSSSSS 297
L + ++ SL L AQ +F ++ D +Q NV + SS+
Sbjct: 3182 LLNSLLDIVSSLSALLAKAQHVFEYLPEFLHTFKITALLETLDFQQVSQ---NVQARSSA 3238
Query: 298 TQIYQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNGTEEDAETF-YDNSTTPYCN 356
+Q V ++VC + S + K L E+D E F +TP+C
Sbjct: 3239 FGSFQFVMKMVC--KDQASFLSDSNMFINLPRVKELL-----EDDKEKFNIPEDSTPFCL 3291
Query: 357 DLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMW 416
L + + P ++W LKP+L GKILYTP+TP +V+ + N TF + L
Sbjct: 3292 KLYQEILQLPNGALVWTFLKPILHGKILYTPNTPEINKVIQKANYTFYIVDKLKTLSETL 3351
Query: 417 EELSPKIWTFMENSQEMDLVRMLLDSRDNDHFWEQQLDGLDWTAQDIVAFLAKHPEDVQS 476
E+S ++ + Q + ++ L ++ +F E QL +D + K E +Q+
Sbjct: 3352 LEMS-SLFQRSGSGQMFNQLQEALRNKFVRNFVENQLH-ID---------VDKLTEKLQT 3400
Query: 477 SNGSVYTWREAFNETNQA-IRTISRFM----ECVNLNKLEPIATEVWLINKSMELLDERK 531
G + E FN R + + CV LN+ + + + L K+ ELL +
Sbjct: 3401 YGGLL---DEMFNHAGAGRFRFLGSILVNLSSCVALNRFQALQSVDILETKAHELLQQNS 3457
Query: 532 FWAGIVFTG------ITPGSIELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFED 585
F A I+F+ S++LP HV Y IR ++ RT+ +K+ W P+ P +
Sbjct: 3458 FLASIIFSNSLFDKNFRSESVKLPPHVSYTIRTNVLYSVRTDVVKNPSWKFHPQNLPADG 3517
Query: 586 MRYVWGGFAYLQDVVEQAIIRVLTGTEK-KTGVYMQQMPYPCYVDDIFLRVMSRSMPLFM 644
+Y + FA LQD++E+AII V TG E + Q PYPC+ D+FL + PL M
Sbjct: 3518 FKYNYV-FAPLQDMIERAIILVQTGQEALEPAAQTQAAPYPCHTSDLFLNNVGFFFPLIM 3576
Query: 645 TLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVIL 704
L W+ SVA +++ +VYE+E +++E MR+MG+ I + +WF+ ++ L +S+ L ++L
Sbjct: 3577 MLTWMVSVASMVRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVL 3636
Query: 705 KLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLC 764
K + +S+ +VF+FL F + ++ +L+S FS+AN AA C ++Y +LPY++
Sbjct: 3637 KTSGIFAHSNTFIVFLFLLDFGMSVVMLSYLLSAFFSQANTAALCTSLVYMISFLPYIVL 3696
Query: 765 VAWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTS 824
+ + + F + F LLS AFG G + E Q G+QW+N++++ +E+ G
Sbjct: 3697 LVLHNQLSFVNQTFLCLLSTTAFGQGVFFITFLEGQETGIQWNNMYQA-LEQGGMTFGWV 3755
Query: 825 VSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYW------------------- 865
M+LFD+ LY + WY+ + PG +G+ +PWYFP T SYW
Sbjct: 3756 CWMILFDSSLYFLCGWYLSNLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLF 3815
Query: 866 -FGEESDEKSHPGSNQKRISEICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFY 924
F E D K N+ E E GV++ ++ K Y +G K V L+L FY
Sbjct: 3816 FFNENFDNKGSSLQNR--------EGELEGSAPGVTLVSVTKEY-EGHKAVVQDLSLTFY 3866
Query: 925 EGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVL 984
QIT+ LG NGAGKTT +S+LTGL PPTSGT I GK++++++S +R LGVCPQ ++L
Sbjct: 3867 RDQITALLGTNGAGKTTIISMLTGLHPPTSGTIIINGKNLQTDLSRVRMELGVCPQQDIL 3926
Query: 985 FDMLTVEEHIWFYARLKG--LSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQRKLS 1042
D LTV EH+ +A +K ++K + ++ Q DV L + K +T LSGG++RKLS
Sbjct: 3927 LDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQHK-QTRALSGGLKRKLS 3985
Query: 1043 VALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDRIA 1102
+ +AF+G S+ V+LDEPT+GVDP SR +W++LLKYR+GRTII +THH+DEA+ L DR+A
Sbjct: 3986 LGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTIIFTTHHLDEAEALSDRVA 4045
Query: 1103 IISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSS 1162
++ HG+L C G LK G G LTL ++ S L+ D
Sbjct: 4046 VLQHGRLRCCGPPFCLKEAYGQGLRLTLTRQP---------------SVLEAHD------ 4084
Query: 1163 SDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELF 1222
D++ +++LI+ ++ +A L + G ELTY +P + K LF
Sbjct: 4085 --------------LKDMACVTSLIKIYIPQAFLKDSSGSELTYTIPKDTDK-ACLKGLF 4129
Query: 1223 HEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQ--- 1279
+D+ L L ++ YGIS+TTLEE+FL + ++S + + GT +N R G
Sbjct: 4130 QALDENLHQLHLTGYGISDTTLEEVFLMLLQDSNKKSHIALGTESELQNHRPTGHLSGYC 4189
Query: 1280 -SCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALLWKRLL 1338
S RP T V+G +L + Q A+L +RL
Sbjct: 4190 GSLARPAT--------------------------------VQGVQLLRAQVAAILARRLR 4217
Query: 1339 IARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPED 1398
R+ K A ++LP +FV +A+ ++ P +YP L L P Y T+ + ++
Sbjct: 4218 RTLRAGKSTLADLLLPVLFVALAMGLFMVRPLATEYPPLRLTPGHYQRAETYFFSSGGDN 4277
Query: 1399 TGTLELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAPVPQTIMDLFQNGNWTMQN 1458
+L +D C + N P Q W T P FQ+
Sbjct: 4278 LDLTRVLLRKFRDQDL--PCADLN-----PRQKNSSCWRTDPFSH---PEFQD------- 4320
Query: 1459 PSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDLTGRNISDYLVKTYVQIIA 1518
+C C CP + P + L +L+G N+ +YL +A
Sbjct: 4321 ---SCGCLK---------CPNRSAS--APYLTNHLGHTLLNLSGFNMEEYL-------LA 4359
Query: 1519 KSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDAIKQMKKHLKLAKDSSADRFLNSLG 1578
S K R GG+S G L E A + K LA
Sbjct: 4360 PSEKP-------RLGGWSFG------LKIPSEAGGANGNISKPPTLA------------- 4393
Query: 1579 RFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSHYGITAFNHPLNL 1638
KVW+N KG+H++ S+LN +NN IL +L + YGIT ++HP
Sbjct: 4394 ------------KVWYNQKGFHSLPSYLNHLNNLILWQHLPPTVDWRQYGITLYSHPYG- 4440
Query: 1639 TKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIY 1698
L++ ++ + V++C++ S + AS ++++RV AK LQ ISG+ +Y
Sbjct: 4441 -GALLNKDKILESIRQCGVALCIVLGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMY 4499
Query: 1699 WLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASF 1758
W +NF++DM Y+V L + + + FQ ++ NL ALLL L+G++ P MY S
Sbjct: 4500 WFTNFLYDMLFYLVSVCLCVAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSR 4559
Query: 1759 VFKIPSTAYVVLTSVNLFIGINGSVATFVLELFT----DNKLNNINDILKSVFLIFPHFC 1814
+F A++ S+N G+ + T + L L NI D+LK VF IFP FC
Sbjct: 4560 IFSSSDVAFISYVSLNFIFGLCTMLITIMPRLLAIISKAKNLQNIYDVLKWVFTIFPQFC 4619
Query: 1815 LGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRF 1874
LG+GL+++ NQ D FG + +VSP + +G +A +G V L+ VL+ +
Sbjct: 4620 LGQGLVELCYNQIKYDLTHNFGIDSYVSPFEMNFLGWIFVQLASQGTVLLLLRVLLHWDL 4679
Query: 1875 FIRPRPVNAKLSPL-NDEDEDVRRERQRILDGGGQNDILEIKELTKIYRR--KRKPAVDR 1931
PR + + + +D DV +E +R+ +G DIL + L+K YRR + AV
Sbjct: 4680 LRWPRGHSTLQGTVKSSKDTDVEKEEKRVFEGRTNGDILVLYNLSKHYRRFFQNIIAVQD 4739
Query: 1932 ICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNS----ILSNIHEVHQN 1987
I +GIP GECFGLLGVNGAGKS+TFKML G+ ++T G A + LS+
Sbjct: 4740 ISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTAGVL 4799
Query: 1988 MGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSG 2047
+GYCPQ DA+ ELLTG EH+ ++ LRG+P + + +V IR+L L + +K YSG
Sbjct: 4800 IGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATYSG 4859
Query: 2048 GNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEEC 2107
G KRKLSTA+AL+G P ++ LDEP++GMDP ++R+LW + V+EG + VLTSHSMEEC
Sbjct: 4860 GTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVLTSHSMEEC 4919
Query: 2108 EALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGSV 2167
EALCTR+AIMVNG F+CLGS QH+KNRFGDGYT+ V + V D L FPG
Sbjct: 4920 EALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQHCTVSDHLKLYFPGIQ 4979
Query: 2168 LKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQ 2224
K +H N+L+Y +P LA +F ++ +K L+I+ YS++QTTL+QVF+NFA +Q
Sbjct: 4980 FKGQHLNLLEYHVPKRWGCLADLFKVIENNKTFLNIKHYSINQTTLEQVFINFASEQ 5036
Score = 184 bits (466), Expect = 1e-45
Identities = 163/600 (27%), Positives = 277/600 (46%), Gaps = 55/600 (9%)
Query: 1670 ASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVP-ATLVIIIFICFQQKS 1728
AS V L+ E+ + + + GV PVI++L+ F+ +M + ATL I++ +
Sbjct: 3585 ASMVRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVL----KTSG 3640
Query: 1729 YVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVL 1788
+ +N ++ L LL +G S+ L Y S F +TA + + V + S +++
Sbjct: 3641 IFAHSNTFIVFLFLLDFGMSVVMLSYLLSAFFSQANTAALCTSLVYMI-----SFLPYIV 3695
Query: 1789 ELFTDNKLNNINDILKSVFLIFPHFCLGRGL--IDMVKNQA-------MADALERFGEN- 1838
L N+L+ +N ++ + G+G+ I ++ Q M ALE+ G
Sbjct: 3696 LLVLHNQLSFVN---QTFLCLLSTTAFGQGVFFITFLEGQETGIQWNNMYQALEQGGMTF 3752
Query: 1839 -------RFVSPL----SWDLVGR--NLFAMAVEGVVFFLITVLIQYRFFIRPRP--VNA 1883
F S L W L F + F + F + R +++
Sbjct: 3753 GWVCWMILFDSSLYFLCGWYLSNLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSS 3812
Query: 1884 KLSPLN---DEDEDVRRERQRILDGGGQNDILEIKELTKIYRRKRKPAVDRICVGIPPGE 1940
L N D + R+ L+G + + +TK Y K V + + +
Sbjct: 3813 SLFFFNENFDNKGSSLQNREGELEGSAPG--VTLVSVTKEYEG-HKAVVQDLSLTFYRDQ 3869
Query: 1941 CFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITEL 2000
LLG NGAGK++ MLTG T G +N ++ +++ V +G CPQ D + +
Sbjct: 3870 ITALLGTNGAGKTTIISMLTGLHPPTSGTIIINGKNLQTDLSRVRMELGVCPQQDILLDN 3929
Query: 2001 LTGREHVEFFALLRGV--PEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMA 2058
LT REH+ FA ++ +KE+ + ++ + L ++ K SGG KRKLS +A
Sbjct: 3930 LTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIA 3989
Query: 2059 LIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMV 2118
+G V LDEPT+G+DP +R LW+ L +EGR+++ T+H ++E EAL R+A++
Sbjct: 3990 FMGMSRTVVLDEPTSGVDPCSRHSLWDILLK-YREGRTIIFTTHHLDEAEALSDRVAVLQ 4048
Query: 2119 NGRFRCLGSVQHLKNRFGDGYTIV------VRIAGSNPDLKPVQDFFGLAFPGSVLKEKH 2172
+GR RC G LK +G G + V A D+ V + P + LK+
Sbjct: 4049 HGRLRCCGPPFCLKEAYGQGLRLTLTRQPSVLEAHDLKDMACVTSLIKIYIPQAFLKDSS 4108
Query: 2173 RNMLQYQLP--SSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHL 2230
+ L Y +P + + L +F L ++ +LH+ Y +S TTL++VF+ +D + H+
Sbjct: 4109 GSELTYTIPKDTDKACLKGLFQALDENLHQLHLTGYGISDTTLEEVFLMLLQDSNKKSHI 4168
Score = 65.1 bits (157), Expect = 8e-10
Identities = 29/83 (34%), Positives = 43/83 (51%)
Query: 6 QLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAG 65
Q + LLWKN R R L E WP +F+IL +R PP + C+ + +PS G
Sbjct: 7 QFKALLWKNWLCRLRNPVLFLAEFFWPCILFVILTVLRFQEPPRYRDICYLQPRDLPSCG 66
Query: 66 TLPWVQGIICNANNPCFRYPTPG 88
+P+VQ ++CN + C + G
Sbjct: 67 VIPFVQSLLCNTGSRCRNFSYEG 89
>gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo
sapiens]
Length = 1704
Score = 538 bits (1385), Expect = e-152
Identities = 327/821 (39%), Positives = 471/821 (57%), Gaps = 100/821 (12%)
Query: 575 DPGPRADPFED---MRYVWGGFAYLQDVVEQAIIRVLTGTE-----KKTGVYMQQMPYPC 626
+PGPR D Y+ GF +Q V++AI+ ++ V +++ PYP
Sbjct: 190 NPGPREPTSPDGGEPGYIREGFLAVQHAVDRAIMEYHADAATRQLFQRLTVTIKRFPYPP 249
Query: 627 YVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWF 686
++ D FL + +PL + L++ Y+ I + +V EKE RLKE MR+MGL + + W +WF
Sbjct: 250 FIADPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWF 309
Query: 687 ISSLIPLLVSAGLLVVILKLG-----NLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFS 741
+ + LL++A + ++ + +L SDPS+V FL FA+ TI F++ST FS
Sbjct: 310 LLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFFS 369
Query: 742 RANLAAACGGIIYFTLYLPYVLCVAWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQG 801
+AN+AAA GG +YF Y+PY +++ + K+ + LLS VA G + FE +G
Sbjct: 370 KANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQLIGKFEAKG 429
Query: 802 IGVQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCT 861
+G+QW +L +D F + M+L D+ LYG++TWY+EAVFPGQ+G+P+PWYF
Sbjct: 430 MGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIM 489
Query: 862 KSYWFGE------ESDEKSHPGSNQKRISEICMEEEPTHLKLGVSIQNLVKVYRDGMK-- 913
SYW G+ + +E S P +K + E EP L G+ I++L KV+R G K
Sbjct: 490 PSYWCGKPRAVAGKEEEDSDP---EKALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNKDR 546
Query: 914 VAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQ 973
AV L LN YEGQIT LGHNGAGKTTT+S+LTGLFPPTSG AYI G +I +M IR+
Sbjct: 547 AAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQIRK 606
Query: 974 NLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQL 1033
+LG+CPQH++LFD LTV EH++FYA+LKGLS + E++QM +GL K S++ L
Sbjct: 607 SLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGL-EDKWNSRSRFL 665
Query: 1034 SGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDE 1093
SGGM+RKLS+ +A + GSKV+ILDEPT+G+D SRR IW+LL + + RTI+L+TH MDE
Sbjct: 666 SGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDE 725
Query: 1094 ADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLK 1153
AD+LGDRIAI++ G+L C GSSLFLK + G GY++TLVK+ +
Sbjct: 726 ADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKE----------------PHCN 769
Query: 1154 KEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAA 1213
ED IS L+ HV A L G EL+++LP E+
Sbjct: 770 PED--------------------------ISQLVHHHVPNATLESSAGAELSFILPREST 803
Query: 1214 KEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAE--ESGVDAETSDGTLPA--- 1268
F LF +++ + +LGI+S+G S TT+EE+FL+V + +S +D + LPA
Sbjct: 804 HR--FEGLFAKLEKKQKELGIASFGASITTMEEVFLRVGKLVDSSMDIQAIQ--LPALQY 859
Query: 1269 RRNRRAFG---DKQSCLRPFTEDDAADPND---SDIDPESRETDLLSGMDGKGSYQVKGW 1322
+ RRA D C A DP+D + I+ E L +G+
Sbjct: 860 QHERRASDWAVDSNLC-------GAMDPSDGIGALIEEERTAVKLNTGL----------- 901
Query: 1323 KLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALV 1363
L QQF A+ K+ + R K AQ+++P V +AL+
Sbjct: 902 ALHCQQFWAMFLKKAAYSWREWKMVAAQVLVPLTCVTLALL 942
Score = 468 bits (1205), Expect = e-131
Identities = 260/663 (39%), Positives = 399/663 (60%), Gaps = 38/663 (5%)
Query: 1590 VKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSHYGITAFNHPLNLTKQQLSEVALM 1649
V FNN+ +H+ ++ L V++N + + L G H I N P + Q ++
Sbjct: 1038 VNALFNNQAYHSPATALAVVDNLLFK--LLCGP---HASIVVSNFPQPRSALQAAKDQFN 1092
Query: 1650 TTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCN 1709
+++ ++FAM+F+ ++F + + ER +AKH+QF+SGV +WLS +WD+ +
Sbjct: 1093 EGRKGFDIALNLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDLIS 1152
Query: 1710 YVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVV 1769
+++P+ L++++F F +++ ++ LLLLLYGW+I PLMY +F F +TAY
Sbjct: 1153 FLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAYTR 1212
Query: 1770 LTSVNLFIGINGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKN---- 1825
LT N+ GI + ++ + KL ++ L VFL+ P+ CLG + +N
Sbjct: 1213 LTIFNILSGIATFLMVTIMRI-PAVKLEELSKTLDHVFLVLPNHCLGMAVSSFYENYETR 1271
Query: 1826 ------QAMADALERFGENRFVSPLSWDL--VGRNLFAMAVEGVVFFLITVLIQYRFFIR 1877
+ A +++ + +W VGR + +MA G + ++ LI+ R
Sbjct: 1272 RYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLILLFLIETNLLQR 1331
Query: 1878 PRPVNAKLS------------PLNDEDEDVRRERQRILDGGGQNDI---LEIKELTKIYR 1922
R + L P+ ED+DV ER RIL + + L IKEL+K+Y
Sbjct: 1332 LRGILCALRRRRTLTELYTRMPVLPEDQDVADERTRILAPSPDSLLHTPLIIKELSKVYE 1391
Query: 1923 RKRKP--AVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSN 1980
+ R P AVDR+ + + GECFGLLG NGAGK++TFKMLTG+ ++T GDAF+ + I S+
Sbjct: 1392 Q-RVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSD 1450
Query: 1981 IHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEK 2040
+ +V Q +GYCPQFDA+ + +TGRE + +A LRG+PE+ +G E +R L L + K
Sbjct: 1451 VGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANK 1510
Query: 2041 YAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLT 2100
YSGGNKRKLST +ALIG P V+FLDEP+TGMDP ARR LW+ + G+++++T
Sbjct: 1511 LVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIIT 1570
Query: 2101 SHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRI--AGSNPDLKPVQDF 2158
SHSMEECEALCTR+AIMV G+F+CLGS QHLK++FG GY++ ++ G L+ + F
Sbjct: 1571 SHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFKAF 1630
Query: 2159 FGLAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFV 2218
L FPGSVL+++H+ M+ Y LP S A++F IL ++K++ ++DYSVSQ +L+QVF+
Sbjct: 1631 VDLTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGILEKAKEKYGVDDYSVSQISLEQVFL 1690
Query: 2219 NFA 2221
+FA
Sbjct: 1691 SFA 1693
Score = 182 bits (461), Expect = 4e-45
Identities = 159/606 (26%), Positives = 291/606 (48%), Gaps = 57/606 (9%)
Query: 1652 SVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYV 1711
++ + + ++ + ++ + ++QE+ + K + G+ ++W + F+ +
Sbjct: 258 AIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLL 317
Query: 1712 VPATLVIIIFICFQQKSYVS--STNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVV 1769
+ A+ + ++F C + K V+ S + P L L LL ++I+ + SF F + +
Sbjct: 318 IAASFMTLLF-CVKVKPNVAVLSRSDPSLVLAFLLC-FAISTI----SFSFMVST----F 367
Query: 1770 LTSVNLFIGINGSVA--TFVLELFTDNKLN--NINDILKSVFLIFPHFCLGRGLIDMVKN 1825
+ N+ G + T++ F + N ++ L S L +G LI +
Sbjct: 368 FSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQLIGKFEA 427
Query: 1826 QAMADALERFGENRFVSPLSWD---LVGRNLFAMAVEGVVFFLITVLIQ----------- 1871
+ M +SP++ D G+ L + ++ V++ L+T ++
Sbjct: 428 KGMG-----IQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQ 482
Query: 1872 -YRFFI-------RPRPVNAKLSPLNDEDEDVRRERQRILDGGGQNDI---LEIKELTKI 1920
+ FFI +PR V K +ED D + + D+ ++IK L+K+
Sbjct: 483 PWYFFIMPSYWCGKPRAVAGK----EEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKV 538
Query: 1921 YR--RKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSIL 1978
+R K + AV + + + G+ LLG NGAGK++T MLTG T G A+++ I
Sbjct: 539 FRVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEIS 598
Query: 1979 SNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYG 2038
++ ++ +++G CPQ D + + LT EH+ F+A L+G+ ++ + + + +GL
Sbjct: 599 QDMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKW 658
Query: 2039 EKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVV 2098
+ SGG +RKLS +ALI G V+ LDEPT+GMD +RR +W+ L K R++V
Sbjct: 659 NSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWD-LLQRQKSDRTIV 717
Query: 2099 LTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTI-VVRIAGSNPDLKPVQD 2157
LT+H M+E + L R+AIM G +C GS LK ++G GY + +V+ NP+ +
Sbjct: 718 LTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPE--DISQ 775
Query: 2158 FFGLAFPGSVLKEKHRNMLQYQLP-SSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQV 2216
P + L+ L + LP S +F+ L + +K L I + S TT+++V
Sbjct: 776 LVHHHVPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEV 835
Query: 2217 FVNFAK 2222
F+ K
Sbjct: 836 FLRVGK 841
Score = 167 bits (423), Expect = 1e-40
Identities = 94/231 (40%), Positives = 143/231 (61%), Gaps = 5/231 (2%)
Query: 901 IQNLVKVYRDGMKV-AVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYI 959
I+ L KVY + + AVD L+L +G+ LG NGAGKTTT +LTG TSG A++
Sbjct: 1383 IKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFV 1442
Query: 960 LGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDV 1019
G I S++ +RQ +G CPQ + L D +T E + YARL+G+ E+H+ A +E +
Sbjct: 1443 GGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGL 1502
Query: 1020 GL-PSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKY 1078
L P + +T SGG +RKLS +A +G V+ LDEP+ G+DP +RR +W+ + +
Sbjct: 1503 LLEPHANKLVRT--YSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARA 1560
Query: 1079 RQ-GRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYL 1128
R+ G+ II+++H M+E + L R+AI+ G+ C+GS LK++ G+GY L
Sbjct: 1561 RESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSL 1611
Score = 37.7 bits (86), Expect = 0.13
Identities = 21/44 (47%), Positives = 27/44 (61%)
Query: 1 MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRL 44
MA QL LLLWKN T ++R+ +LE+ PL ILI +RL
Sbjct: 1 MAVLRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRL 44
>gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo
sapiens]
Length = 1543
Score = 302 bits (773), Expect = 3e-81
Identities = 213/696 (30%), Positives = 341/696 (48%), Gaps = 83/696 (11%)
Query: 587 RYVWGGFAYLQDVVEQAIIRVLTG---TEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLF 643
+Y GF Q + AII V T E+ T V M P ++ +M+ F
Sbjct: 82 KYWLKGFVAFQAAINAAIIEVTTNHSVMEELTSVIGINMKIPPFISKG--EIMNEWFH-F 138
Query: 644 MTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVI 703
L S V + + K+ M +MGL S W SW ++ + + + + + ++
Sbjct: 139 TCLVSFSSFIYFASLNVARERGKFKKLMTVMGLRESAFWLSWGLTYICFIFIMSIFMALV 198
Query: 704 LKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACG-------GIIYFT 756
+ ++ ++ V+F S++ + I FL+S L + LA G G + FT
Sbjct: 199 ITSIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPMLAGLAGFLFTVFWGCLGFT 258
Query: 757 -LYLPYVLCVAWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVE 815
LY L + W SLLSP AF G + GV +F P
Sbjct: 259 VLYRQLPLSLGW----------VLSLLSPFAFTAGMAQITHLDNYLSGV----IFPDP-S 303
Query: 816 EDGFNLTTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEESD--EK 873
D + + + ++ FDT Y + T Y E V P + G F S+W ++ E
Sbjct: 304 GDSYKMIATFFILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQNTHHEI 363
Query: 874 SHPGSNQKRISEICME--EEPTHLKLGVSIQNLVKVY--RDGMKVAVDGLALNFYEGQIT 929
N + S+ E H K + I+N++K Y + G A+ G+ + YEGQIT
Sbjct: 364 FENEINPEHSSDDSFEPVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYEGQIT 423
Query: 930 SFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIR--SEMSTIRQNLGVCPQHNVLFDM 987
+ LGHNGAGK+T ++IL+GL T G+A I + ++M IR+N+G CPQ N FD
Sbjct: 424 AILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQFDF 483
Query: 988 LTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAF 1047
LTV E++ +A++KG+ K V+ E++++ +++ + S + +LSGG +RKL++ +A
Sbjct: 484 LTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQ-DIIAKKLSGGQKRKLTLGIAI 542
Query: 1048 VGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDRIAIISHG 1107
+G +V++LDEPTAG+DP+SR +W LL +++ R I+ ST MDEAD+L DR +S+G
Sbjct: 543 LGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRKVFLSNG 602
Query: 1108 KLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSSSDAGL 1167
KL C GSSLFLK + G GY+L+L + ++
Sbjct: 603 KLKCAGSSLFLKRKWGIGYHLSLHRNEM-------------------------------- 630
Query: 1168 GSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDD 1227
D I++LI++H+ +A+L + +L Y LP E K F +L+ ++ D
Sbjct: 631 ----------CDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLE--KTNKFPDLYSDL-D 677
Query: 1228 RLSDLGISSYGISETTLEEIFLKVAEESGVDAETSD 1263
+ SD GI +Y +S T+L E+FL + +S +D D
Sbjct: 678 KCSDQGIRNYAVSVTSLNEVFLNLEGKSAIDEPDFD 713
Score = 211 bits (536), Expect = 9e-54
Identities = 172/611 (28%), Positives = 296/611 (48%), Gaps = 63/611 (10%)
Query: 1661 VIFAMSFVPASFVVFLIQERVSK----------AKHLQ---FISGVKPVIYWLSNFVWDM 1707
++ + F+ S + LI VS K++Q +ISG+ P YW + D+
Sbjct: 926 IVLDLGFIDGSIFLLLITNCVSPFIGMSSISDYKKNVQSQLWISGLWPSAYWCGQALVDI 985
Query: 1708 CNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAY 1767
Y + + +I+ +S + VL + ++ S+ L Y SF+F+
Sbjct: 986 PLYFLILFSIHLIYYFIFLGFQLSWELMFVLVVCIIGCAVSLIFLTYVLSFIFR-KWRKN 1044
Query: 1768 VVLTSVNLFIGINGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQA 1827
S FI + V + + +N IL +F+ P F L ++ +++
Sbjct: 1045 NGFWSFGFFI-----ILICVSTIMVSTQYEKLNLILCMIFI--PSFTLLGYVMLLIQLDF 1097
Query: 1828 MA--DALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQ------------YR 1873
M D+L+ NR ++ ++ ++ L + F+I L +R
Sbjct: 1098 MRNLDSLD----NR-INEVNKTILLTTLIPYLQSVIFLFVIRCLEMKYGNEIMNKDPVFR 1152
Query: 1874 FFIRPRPVNAKLSPLNDEDEDVRRERQRILDGGGQNDILEIKELT-----KIY------- 1921
R R + +EDEDV+ ER + + ++ E +T K Y
Sbjct: 1153 ISPRSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVITASCLHKEYYETKKSC 1212
Query: 1922 --RRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILS 1979
RK+K A+ + + GE GLLG NGAGKS++ KM+TG T T G L + +
Sbjct: 1213 FSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSR--A 1270
Query: 1980 NIHEVHQN----MGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLV 2035
++ + H N +GYCPQ +++ LT +EH+E +A ++G+ +++ + L L
Sbjct: 1271 SVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQ 1330
Query: 2036 KYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVK-EG 2094
+ + S G KRKL ++++G P VV LDEP TGMDP+ ++ +W + VK +
Sbjct: 1331 EQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKE 1390
Query: 2095 RSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKP 2154
R +LT+H M E EA+C RMA+MV+G RC+GS+QHLKN+FG Y + +++ ++
Sbjct: 1391 RGTLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMK-EPTQVEA 1449
Query: 2155 VQDFFGLAFPGSVLKEKHRNMLQYQLP-SSLSSLARIFSILSQSKKRLHIEDYSVSQTTL 2213
+ FP + +E++ +++ Y+LP + L+R F L K+ ++E+YS+SQ TL
Sbjct: 1450 LHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTFNLEEYSLSQATL 1509
Query: 2214 DQVFVNFAKDQ 2224
+QVF+ K+Q
Sbjct: 1510 EQVFLELCKEQ 1520
Score = 159 bits (402), Expect = 3e-38
Identities = 105/351 (29%), Positives = 181/351 (51%), Gaps = 12/351 (3%)
Query: 1910 DILEIKELTKIYRRK--RKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTR 1967
+ + I+ + K Y K + A+ I I G+ +LG NGAGKS+ +L+G + T
Sbjct: 389 EAIRIRNVIKEYNGKTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTE 448
Query: 1968 GDAFLNKNSI--LSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVG 2025
G A + + ++++ E+ +N+G+CPQF+ + LT RE++ FA ++G+ KEV +
Sbjct: 449 GSATIYNTQLSEITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQEV 508
Query: 2026 EWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWN 2085
+ I +L + + A SGG KRKL+ +A++G P V+ LDEPT G+DP +R +W+
Sbjct: 509 KRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWS 568
Query: 2086 CALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRI 2145
L K R ++ ++ M+E + L R + NG+ +C GS LK ++G GY + +
Sbjct: 569 -LLKEHKVDRLILFSTQFMDEADILADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLH- 626
Query: 2146 AGSNPDLKPVQDFFGLAFPGSVLKEKHRNMLQYQLP-SSLSSLARIFSILSQSKKRLHIE 2204
D + + P + L + L Y LP + ++S L + + I
Sbjct: 627 RNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNKFPDLYSDLDKCSDQ-GIR 685
Query: 2205 DYSVSQTTLDQVFVNF----AKDQSDDDHLKDLSLHKNQTVVDVAVLTSFL 2251
+Y+VS T+L++VF+N A D+ D D K +H + D + + L
Sbjct: 686 NYAVSVTSLNEVFLNLEGKSAIDEPDFDIGKQEKIHVTRNTGDESEMEQVL 736
Score = 154 bits (390), Expect = 7e-37
Identities = 99/347 (28%), Positives = 169/347 (48%), Gaps = 51/347 (14%)
Query: 913 KVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGK--DIRSEMST 970
K+A+ ++ +G++ LGHNGAGK+T++ ++TG PT+G + G +R +
Sbjct: 1219 KIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDN 1278
Query: 971 IRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKT 1030
+ LG CPQ N L+ LT++EH+ YA +KGL ++ + ++ + L +LK+
Sbjct: 1279 SLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKL-QEQLKAPV 1337
Query: 1031 SQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELL---LKYRQGRTIILS 1087
LS G++RKL L+ +G VV+LDEP G+DP ++ +W++L +K ++ R +L+
Sbjct: 1338 KTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKE-RGTLLT 1396
Query: 1088 THHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSS 1147
TH+M EA+ + DR+A++ G L C+GS LKN+ G Y L + K+
Sbjct: 1397 THYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMKE------------- 1443
Query: 1148 TVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYV 1207
V A+ I K +A E + Y
Sbjct: 1444 -----------------------------PTQVEALHTEILKLFPQAAWQERYSSLMAYK 1474
Query: 1208 LPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEE 1254
LP E F +++ + Y +S+ TLE++FL++ +E
Sbjct: 1475 LPVEDVH--PLSRAFFKLEAMKQTFNLEEYSLSQATLEQVFLELCKE 1519
>gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 297 bits (761), Expect = 7e-80
Identities = 221/735 (30%), Positives = 365/735 (49%), Gaps = 93/735 (12%)
Query: 584 EDMRYVWGGFAYLQDVVEQAIIRVLTGT------EKKTGVYMQQMP------YPCYVDDI 631
E +Y GF LQ ++ AII++ T E V M + +P V I
Sbjct: 164 EAAQYWSSGFTVLQASIDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILI 223
Query: 632 FLRVMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLI 691
+L + F+ + IV EKE ++KE ++IMGL ++ W SW +
Sbjct: 224 YLVIAFSPFGYFLAIH-----------IVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTS 272
Query: 692 PLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGG 751
+ + + L+ VI L P S V+F+ ++ + ++ +++ LF ++ G
Sbjct: 273 LIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHV----G 328
Query: 752 IIYFTLYLPYVLCVAWQDYVGFTLKIFASLLSPVA---FGFGCEYFALFEEQGIGVQWDN 808
I+ F + + + + K L SP F G E+ G + N
Sbjct: 329 IVEFFVTVAFGFIGLMIILIESFPKSLVWLFSPFCHCTFVIGIAQVMHLEDFNEGASFSN 388
Query: 809 LFESPVEEDGFNLTTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGE 868
L P + L ++ M+ ++ Y ++ Y++ V PG++G+ R + SYW
Sbjct: 389 LTAGP-----YPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKS 443
Query: 869 ESD-EKSHPGSNQKRISEICMEEEPTHLKLG---VSIQNLVKVYRD-GMKV-AVDGLALN 922
+ + E+ G+ IS + E + +G + I + K YR G V A+ L+ +
Sbjct: 444 KRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFD 503
Query: 923 FYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRS--EMSTIRQNLGVCPQ 980
YEGQIT+ LGH+G GK+T M+IL GL PP+ G A I G + EM R+ +G+CPQ
Sbjct: 504 IYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQ 563
Query: 981 HNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQRK 1040
++ FD+LTVEE++ A +KG+ ++ E++++ LD+ + + K ++ +LSGG +RK
Sbjct: 564 LDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIK-DNQAKKLSGGQKRK 622
Query: 1041 LSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDR 1100
LS+ +A +G K+++LDEPTAG+DP SR +W LL + R + STH MDEAD+L DR
Sbjct: 623 LSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADR 682
Query: 1101 IAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQ 1160
A+IS G L CVGSS+FLK++ G GY L++ Y+ K +
Sbjct: 683 KAVISQGMLKCVGSSMFLKSKWGIGYRLSM--------------------YIDKYCA--- 719
Query: 1161 SSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVE 1220
++S+L+++H+ A L++ +L Y LP++ + F
Sbjct: 720 -------------------TESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDK--FSG 758
Query: 1221 LFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVD-AETSDGT---LPARRNRRAFG 1276
LF +D S+LG+ SYG+S TTLE++FLK+ E+ +D A+ S T L + ++F
Sbjct: 759 LFSALDSH-SNLGVISYGVSMTTLEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFD 817
Query: 1277 DKQSCLRPFTEDDAA 1291
+ + L +E AA
Sbjct: 818 EMEQSLLILSETKAA 832
Score = 232 bits (592), Expect = 3e-60
Identities = 174/611 (28%), Positives = 290/611 (47%), Gaps = 73/611 (11%)
Query: 1668 VPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQK 1727
+P F + + KA +SG+ P YW+ V D+ + + L++ + F
Sbjct: 1035 MPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYG 1094
Query: 1728 SYVSSTNLPVLALLLLLYGWSITPLMYPASFVFK--------------IPSTAYVVLTSV 1773
Y + + L+ Y S+ Y ASF FK + + A + +T +
Sbjct: 1095 LYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEI 1154
Query: 1774 NLFIGINGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALE 1833
F+G ++AT + F +I P + L LI +K +
Sbjct: 1155 TFFMGY--TIATILHYAFC---------------IIIPIYPLLGCLISFIK-------IS 1190
Query: 1834 RFGENRFVSPLS-WDLVGRNLFAMAVEGVVFFLITVLIQYRF---FIRPRPVNAKLSPLN 1889
+ V + WD + + + ++ V++ + + ++ IR P LS +
Sbjct: 1191 WKNVRKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKS 1250
Query: 1890 ------------DEDEDVRRERQRILDGGG-----QNDILEIKELTKIY---------RR 1923
DEDEDV+ ER ++ + G + + + L K Y R+
Sbjct: 1251 KNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRK 1310
Query: 1924 KRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNK-NSILSNIH 1982
+K A I + GE GLLG NGAGKS+ +L GD T G FL +S S
Sbjct: 1311 VKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDD 1370
Query: 1983 EVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYA 2042
+ + MGYCPQ + + T +EH E + ++G+ ++ +V L L ++ +K
Sbjct: 1371 DSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTV 1430
Query: 2043 GNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVK-EGRSVVLTS 2101
G KRKL A++++G P + LDEP+TGMDPKA++ +W + K R+ +LT+
Sbjct: 1431 KKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTT 1490
Query: 2102 HSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAG--SNPDLKPVQDFF 2159
H MEE EA+C R+AIMV+G+ RC+G+VQHLK++FG GY + +++ N ++ +Q
Sbjct: 1491 HYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREI 1550
Query: 2160 GLAFPGSVLKEKHRNMLQYQLP-SSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFV 2218
FP + +E ++L Y++P + SL++ F L ++K IE+YS SQ TL+QVFV
Sbjct: 1551 QYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFV 1610
Query: 2219 NFAKDQSDDDH 2229
K+Q ++D+
Sbjct: 1611 ELTKEQEEEDN 1621
Score = 163 bits (413), Expect = 2e-39
Identities = 163/640 (25%), Positives = 283/640 (44%), Gaps = 112/640 (17%)
Query: 671 MRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAVV-- 728
+++ GL S W + IPL +++IL LG+LL + + F + AVV
Sbjct: 1055 LKLSGLLPSAYWIGQAVVD-IPLF----FIILILMLGSLLAFHY-GLYFYTVKFLAVVFC 1108
Query: 729 -------TILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFTLKIFAS- 780
IL ++ S F + IY L + ++G+T+
Sbjct: 1109 LIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEITFFMGYTIATILHY 1168
Query: 781 ---LLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGV 837
++ P+ GC I + W N+ ++ D +N +S+ + +L V
Sbjct: 1169 AFCIIIPIYPLLGCLI------SFIKISWKNVRKNV---DTYNPWDRLSVAVISPYLQCV 1219
Query: 838 MTWYIEAVFPGQYG---IPRPWYFP--CTKSYWFG-----EESDEKSHPGSNQKRISEI- 886
+ ++ + +YG I + +F TKS + DE + + ++ E+
Sbjct: 1220 LWIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPDNEDEDEDVKAERLKVKELM 1279
Query: 887 ---CMEEEPTHLKLGVSIQNLVKVYRDGM---------KVAVDGLALNFYEGQITSFLGH 934
C EE+P+ + + NL K Y D KVA ++ +G+I LG
Sbjct: 1280 GCQCCEEKPS-----IMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGP 1334
Query: 935 NGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNL---GVCPQHNVLFDMLTVE 991
NGAGK+T ++IL G PTSG ++ D SE S +L G CPQ N L+ T++
Sbjct: 1335 NGAGKSTIINILVGDIEPTSGQVFL--GDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQ 1392
Query: 992 EHIWFYARLKGLSEKHVKAEMEQM--ALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVG 1049
EH Y +KG+S +K + ++ ALD+ L+ +L G++RKL AL+ +G
Sbjct: 1393 EHFEIYGAVKGMSASDMKEVISRITHALDL---KEHLQKTVKKLPAGIKRKLCFALSMLG 1449
Query: 1050 GSKVVILDEPTAGVDPYSRRGIWELL---LKYRQGRTIILSTHHMDEADVLGDRIAIISH 1106
++ +LDEP+ G+DP +++ +W + K R+ R IL+TH+M+EA+ + DR+AI+
Sbjct: 1450 NPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRK-RAAILTTHYMEEAEAVCDRVAIMVS 1508
Query: 1107 GKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSSSDAG 1166
G+L C+G+ LK++ G GY+L + KD +L
Sbjct: 1509 GQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENL--------------------------- 1541
Query: 1167 LGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEID 1226
+V + I+ A E L Y +P E + + + F +++
Sbjct: 1542 ------------EVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQ--SLSQSFFKLE 1587
Query: 1227 DRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTL 1266
+ I Y S+ TLE++F+++ +E + + S GTL
Sbjct: 1588 EAKHAFAIEEYSFSQATLEQVFVELTKEQ-EEEDNSCGTL 1626
Score = 160 bits (404), Expect = 2e-38
Identities = 155/629 (24%), Positives = 273/629 (43%), Gaps = 60/629 (9%)
Query: 1659 ICVIFAMSFVPASF--VVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATL 1716
I + ++F P + + ++ E+ K K I G+ +WLS + + + L
Sbjct: 221 ILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLL 280
Query: 1717 VIIIF---ICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSV 1773
+ +I + F Q S + V+ LL LYG S + +FK +V V
Sbjct: 281 MAVIATASLLFPQSSSI------VIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFV 334
Query: 1774 NLFIGINGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALE 1833
+ G G + ++E F KS+ +F FC +I + A LE
Sbjct: 335 TVAFGFIG-LMIILIESFP-----------KSLVWLFSPFCHCTFVIGI----AQVMHLE 378
Query: 1834 RFGENRFVSPLS---WDLVGRNLFAMAVEGVVFFLITVLIQY------------RFFIRP 1878
F E S L+ + L+ + + + + + L+ V + +F++P
Sbjct: 379 DFNEGASFSNLTAGPYPLI-ITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKP 437
Query: 1879 R---PVNAKLSPLNDEDEDVRRERQRILDGGGQN----DILEIKELTKIYRRKRK--PAV 1929
L++ + + I++ + + I + K YR+K + A+
Sbjct: 438 SYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEAL 497
Query: 1930 DRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFL--NKNSILSNIHEVHQN 1987
+ I G+ LLG +G GKS+ +L G + G A + ++ S + + E +
Sbjct: 498 RNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKM 557
Query: 1988 MGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSG 2047
+G CPQ D ++LT E++ A ++G+P + + + + L + + A SG
Sbjct: 558 IGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSG 617
Query: 2048 GNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEEC 2107
G KRKLS +A++G P ++ LDEPT GMDP +R +WN L K R V ++H M+E
Sbjct: 618 GQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWN-LLKYRKANRVTVFSTHFMDEA 676
Query: 2108 EALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGSV 2167
+ L R A++ G +C+GS LK+++G GY + + I + + PG+
Sbjct: 677 DILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYI-DKYCATESLSSLVKQHIPGAT 735
Query: 2168 LKEKHRNMLQYQLP-SSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSD 2226
L +++ L Y LP + + +FS L S L + Y VS TTL+ VF+ +
Sbjct: 736 LLQQNDQQLVYSLPFKDMDKFSGLFSAL-DSHSNLGVISYGVSMTTLEDVFLKLEVEAEI 794
Query: 2227 DDHLKDLSLHKNQTVVDVAVLTSFLQDEK 2255
D D S+ Q + + SF + E+
Sbjct: 795 DQ--ADYSVFTQQPLEEEMDSKSFDEMEQ 821
>gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 297 bits (761), Expect = 7e-80
Identities = 221/735 (30%), Positives = 365/735 (49%), Gaps = 93/735 (12%)
Query: 584 EDMRYVWGGFAYLQDVVEQAIIRVLTGT------EKKTGVYMQQMP------YPCYVDDI 631
E +Y GF LQ ++ AII++ T E V M + +P V I
Sbjct: 164 EAAQYWSSGFTVLQASIDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILI 223
Query: 632 FLRVMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLI 691
+L + F+ + IV EKE ++KE ++IMGL ++ W SW +
Sbjct: 224 YLVIAFSPFGYFLAIH-----------IVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTS 272
Query: 692 PLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGG 751
+ + + L+ VI L P S V+F+ ++ + ++ +++ LF ++ G
Sbjct: 273 LIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHV----G 328
Query: 752 IIYFTLYLPYVLCVAWQDYVGFTLKIFASLLSPVA---FGFGCEYFALFEEQGIGVQWDN 808
I+ F + + + + K L SP F G E+ G + N
Sbjct: 329 IVEFFVTVAFGFIGLMIILIESFPKSLVWLFSPFCHCTFVIGIAQVMHLEDFNEGASFSN 388
Query: 809 LFESPVEEDGFNLTTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGE 868
L P + L ++ M+ ++ Y ++ Y++ V PG++G+ R + SYW
Sbjct: 389 LTAGP-----YPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKS 443
Query: 869 ESD-EKSHPGSNQKRISEICMEEEPTHLKLG---VSIQNLVKVYRD-GMKV-AVDGLALN 922
+ + E+ G+ IS + E + +G + I + K YR G V A+ L+ +
Sbjct: 444 KRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFD 503
Query: 923 FYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRS--EMSTIRQNLGVCPQ 980
YEGQIT+ LGH+G GK+T M+IL GL PP+ G A I G + EM R+ +G+CPQ
Sbjct: 504 IYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQ 563
Query: 981 HNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQRK 1040
++ FD+LTVEE++ A +KG+ ++ E++++ LD+ + + K ++ +LSGG +RK
Sbjct: 564 LDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIK-DNQAKKLSGGQKRK 622
Query: 1041 LSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDR 1100
LS+ +A +G K+++LDEPTAG+DP SR +W LL + R + STH MDEAD+L DR
Sbjct: 623 LSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADR 682
Query: 1101 IAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQ 1160
A+IS G L CVGSS+FLK++ G GY L++ Y+ K +
Sbjct: 683 KAVISQGMLKCVGSSMFLKSKWGIGYRLSM--------------------YIDKYCA--- 719
Query: 1161 SSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVE 1220
++S+L+++H+ A L++ +L Y LP++ + F
Sbjct: 720 -------------------TESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDK--FSG 758
Query: 1221 LFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVD-AETSDGT---LPARRNRRAFG 1276
LF +D S+LG+ SYG+S TTLE++FLK+ E+ +D A+ S T L + ++F
Sbjct: 759 LFSALDSH-SNLGVISYGVSMTTLEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFD 817
Query: 1277 DKQSCLRPFTEDDAA 1291
+ + L +E AA
Sbjct: 818 EMEQSLLILSETKAA 832
Score = 232 bits (592), Expect = 3e-60
Identities = 174/611 (28%), Positives = 290/611 (47%), Gaps = 73/611 (11%)
Query: 1668 VPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQK 1727
+P F + + KA +SG+ P YW+ V D+ + + L++ + F
Sbjct: 1035 MPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYG 1094
Query: 1728 SYVSSTNLPVLALLLLLYGWSITPLMYPASFVFK--------------IPSTAYVVLTSV 1773
Y + + L+ Y S+ Y ASF FK + + A + +T +
Sbjct: 1095 LYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEI 1154
Query: 1774 NLFIGINGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALE 1833
F+G ++AT + F +I P + L LI +K +
Sbjct: 1155 TFFMGY--TIATILHYAFC---------------IIIPIYPLLGCLISFIK-------IS 1190
Query: 1834 RFGENRFVSPLS-WDLVGRNLFAMAVEGVVFFLITVLIQYRF---FIRPRPVNAKLSPLN 1889
+ V + WD + + + ++ V++ + + ++ IR P LS +
Sbjct: 1191 WKNVRKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKS 1250
Query: 1890 ------------DEDEDVRRERQRILDGGG-----QNDILEIKELTKIY---------RR 1923
DEDEDV+ ER ++ + G + + + L K Y R+
Sbjct: 1251 KNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRK 1310
Query: 1924 KRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNK-NSILSNIH 1982
+K A I + GE GLLG NGAGKS+ +L GD T G FL +S S
Sbjct: 1311 VKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDD 1370
Query: 1983 EVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYA 2042
+ + MGYCPQ + + T +EH E + ++G+ ++ +V L L ++ +K
Sbjct: 1371 DSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTV 1430
Query: 2043 GNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVK-EGRSVVLTS 2101
G KRKL A++++G P + LDEP+TGMDPKA++ +W + K R+ +LT+
Sbjct: 1431 KKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTT 1490
Query: 2102 HSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAG--SNPDLKPVQDFF 2159
H MEE EA+C R+AIMV+G+ RC+G+VQHLK++FG GY + +++ N ++ +Q
Sbjct: 1491 HYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREI 1550
Query: 2160 GLAFPGSVLKEKHRNMLQYQLP-SSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFV 2218
FP + +E ++L Y++P + SL++ F L ++K IE+YS SQ TL+QVFV
Sbjct: 1551 QYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFV 1610
Query: 2219 NFAKDQSDDDH 2229
K+Q ++D+
Sbjct: 1611 ELTKEQEEEDN 1621
Score = 163 bits (413), Expect = 2e-39
Identities = 163/640 (25%), Positives = 283/640 (44%), Gaps = 112/640 (17%)
Query: 671 MRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAVV-- 728
+++ GL S W + IPL +++IL LG+LL + + F + AVV
Sbjct: 1055 LKLSGLLPSAYWIGQAVVD-IPLF----FIILILMLGSLLAFHY-GLYFYTVKFLAVVFC 1108
Query: 729 -------TILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFTLKIFAS- 780
IL ++ S F + IY L + ++G+T+
Sbjct: 1109 LIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEITFFMGYTIATILHY 1168
Query: 781 ---LLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGV 837
++ P+ GC I + W N+ ++ D +N +S+ + +L V
Sbjct: 1169 AFCIIIPIYPLLGCLI------SFIKISWKNVRKNV---DTYNPWDRLSVAVISPYLQCV 1219
Query: 838 MTWYIEAVFPGQYG---IPRPWYFP--CTKSYWFG-----EESDEKSHPGSNQKRISEI- 886
+ ++ + +YG I + +F TKS + DE + + ++ E+
Sbjct: 1220 LWIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPDNEDEDEDVKAERLKVKELM 1279
Query: 887 ---CMEEEPTHLKLGVSIQNLVKVYRDGM---------KVAVDGLALNFYEGQITSFLGH 934
C EE+P+ + + NL K Y D KVA ++ +G+I LG
Sbjct: 1280 GCQCCEEKPS-----IMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGP 1334
Query: 935 NGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNL---GVCPQHNVLFDMLTVE 991
NGAGK+T ++IL G PTSG ++ D SE S +L G CPQ N L+ T++
Sbjct: 1335 NGAGKSTIINILVGDIEPTSGQVFL--GDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQ 1392
Query: 992 EHIWFYARLKGLSEKHVKAEMEQM--ALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVG 1049
EH Y +KG+S +K + ++ ALD+ L+ +L G++RKL AL+ +G
Sbjct: 1393 EHFEIYGAVKGMSASDMKEVISRITHALDL---KEHLQKTVKKLPAGIKRKLCFALSMLG 1449
Query: 1050 GSKVVILDEPTAGVDPYSRRGIWELL---LKYRQGRTIILSTHHMDEADVLGDRIAIISH 1106
++ +LDEP+ G+DP +++ +W + K R+ R IL+TH+M+EA+ + DR+AI+
Sbjct: 1450 NPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRK-RAAILTTHYMEEAEAVCDRVAIMVS 1508
Query: 1107 GKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSSSDAG 1166
G+L C+G+ LK++ G GY+L + KD +L
Sbjct: 1509 GQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENL--------------------------- 1541
Query: 1167 LGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEID 1226
+V + I+ A E L Y +P E + + + F +++
Sbjct: 1542 ------------EVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQ--SLSQSFFKLE 1587
Query: 1227 DRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTL 1266
+ I Y S+ TLE++F+++ +E + + S GTL
Sbjct: 1588 EAKHAFAIEEYSFSQATLEQVFVELTKEQ-EEEDNSCGTL 1626
Score = 160 bits (404), Expect = 2e-38
Identities = 155/629 (24%), Positives = 273/629 (43%), Gaps = 60/629 (9%)
Query: 1659 ICVIFAMSFVPASF--VVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATL 1716
I + ++F P + + ++ E+ K K I G+ +WLS + + + L
Sbjct: 221 ILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLL 280
Query: 1717 VIIIF---ICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSV 1773
+ +I + F Q S + V+ LL LYG S + +FK +V V
Sbjct: 281 MAVIATASLLFPQSSSI------VIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFV 334
Query: 1774 NLFIGINGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALE 1833
+ G G + ++E F KS+ +F FC +I + A LE
Sbjct: 335 TVAFGFIG-LMIILIESFP-----------KSLVWLFSPFCHCTFVIGI----AQVMHLE 378
Query: 1834 RFGENRFVSPLS---WDLVGRNLFAMAVEGVVFFLITVLIQY------------RFFIRP 1878
F E S L+ + L+ + + + + + L+ V + +F++P
Sbjct: 379 DFNEGASFSNLTAGPYPLI-ITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKP 437
Query: 1879 R---PVNAKLSPLNDEDEDVRRERQRILDGGGQN----DILEIKELTKIYRRKRK--PAV 1929
L++ + + I++ + + I + K YR+K + A+
Sbjct: 438 SYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEAL 497
Query: 1930 DRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFL--NKNSILSNIHEVHQN 1987
+ I G+ LLG +G GKS+ +L G + G A + ++ S + + E +
Sbjct: 498 RNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKM 557
Query: 1988 MGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSG 2047
+G CPQ D ++LT E++ A ++G+P + + + + L + + A SG
Sbjct: 558 IGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSG 617
Query: 2048 GNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEEC 2107
G KRKLS +A++G P ++ LDEPT GMDP +R +WN L K R V ++H M+E
Sbjct: 618 GQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWN-LLKYRKANRVTVFSTHFMDEA 676
Query: 2108 EALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGSV 2167
+ L R A++ G +C+GS LK+++G GY + + I + + PG+
Sbjct: 677 DILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYI-DKYCATESLSSLVKQHIPGAT 735
Query: 2168 LKEKHRNMLQYQLP-SSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSD 2226
L +++ L Y LP + + +FS L S L + Y VS TTL+ VF+ +
Sbjct: 736 LLQQNDQQLVYSLPFKDMDKFSGLFSAL-DSHSNLGVISYGVSMTTLEDVFLKLEVEAEI 794
Query: 2227 DDHLKDLSLHKNQTVVDVAVLTSFLQDEK 2255
D D S+ Q + + SF + E+
Sbjct: 795 DQ--ADYSVFTQQPLEEEMDSKSFDEMEQ 821
>gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo
sapiens]
Length = 1624
Score = 287 bits (735), Expect = 7e-77
Identities = 239/825 (28%), Positives = 387/825 (46%), Gaps = 132/825 (16%)
Query: 592 GFAYLQDVVEQAIIRVLTGTE------KKTGVYMQQMPYPCY---VDDIFLRVMSRSMPL 642
GF Q + AII + T TGV+M+ +P+ D F+ S
Sbjct: 177 GFVAFQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFST 236
Query: 643 FMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVV 702
F IY V+V + ++ + M +MGL S W SW + +L+ A L+ +
Sbjct: 237 F-----IYYVSVNVT----QERQYITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMAL 287
Query: 703 ILKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPY- 761
I+K ++ + +VF ++ + I FL+S L + L G++ F L + +
Sbjct: 288 IVKSAQIVVLTGFVMVFTLFLLYGLSLITLAFLMSVLIKKPFLT----GLVVFLLIVFWG 343
Query: 762 -----VLCVAWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVE- 815
L ++ +TL LLSP AF G Q I + +D + ++
Sbjct: 344 ILGFPALYTRLPAFLEWTL----CLLSPFAFTVGMA-------QLIHLDYDVNSNAHLDS 392
Query: 816 -EDGFNLTTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGE------ 868
++ + + ++ M++FDT LY V+T Y + + P +YG F +WF
Sbjct: 393 SQNPYLIIATLFMLVFDTLLYLVLTLYFDKILPAEYGHRCSPLFFLKSCFWFQHGRANHV 452
Query: 869 ----ESDEKSHPGSNQKRIS-EICMEEEPTHLKLGVSIQNLVKVYRDGMK--VAVDGLAL 921
E+D P + +S E C +E + I+NL K Y + A+ G+
Sbjct: 453 VLENETDSDPTPNDCFEPVSPEFCGKE-------AIRIKNLKKEYAGKCERVEALKGVVF 505
Query: 922 NFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIR--SEMSTIRQNLGVCP 979
+ YEGQIT+ LGH+GAGKTT ++IL+GL PTSG+ + + +++ I + G CP
Sbjct: 506 DIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCP 565
Query: 980 QHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQR 1039
Q NV F LTV+E++ +A++KG+ V+ E++++ ++ + + + LSGG R
Sbjct: 566 QSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQ-DILAQNLSGGQNR 624
Query: 1040 KLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGD 1099
KL+ +A +G +V++LDEPTAG+DP SR IW LL + + R I+ ST +DEAD+L D
Sbjct: 625 KLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRVILFSTQFIDEADILAD 684
Query: 1100 RIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVS 1159
R IS+GKL C GSSLFLK + G GY+L+L +
Sbjct: 685 RKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNE------------------------- 719
Query: 1160 QSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFV 1219
D +I++L+++H+S+A+L +L Y+LP E + F
Sbjct: 720 -----------------RCDPESITSLVKQHISDAKLTAQSEEKLVYILPLE--RTNKFP 760
Query: 1220 ELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQ 1279
EL+ ++ DR S+ GI YG+S TTL E+FLK+ +S +D E+ G +G Q
Sbjct: 761 ELYRDL-DRCSNQGIEDYGVSITTLNEVFLKLEGKSTID-ESDIG---------IWGQLQ 809
Query: 1280 SCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALLWKRLLI 1339
+ D A S ++ E +LS + + G L +QQ A+ R L
Sbjct: 810 T--------DGAKDIGSLVELE----QVLSSFH-ETRKTISGVALWRQQVCAIAKVRFLK 856
Query: 1340 ARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMY 1384
++ RK + ++L + L+ L + K EL P Y
Sbjct: 857 LKKERKSLWTILLLFGISFIPQLLEHLFYESYQKSYPWELSPNTY 901
Score = 212 bits (539), Expect = 4e-54
Identities = 173/598 (28%), Positives = 287/598 (47%), Gaps = 57/598 (9%)
Query: 1670 ASFVVFLIQERVS---KAKHLQF-ISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQ 1725
ASF ++ + K H Q ISG+ P YW + D+ Y + L+ I+ F
Sbjct: 1034 ASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFLILLLMQIMDYIFS 1093
Query: 1726 QKSYVSST-NLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVA 1784
+ + NL + L + Y S+ L Y SF+F+ + + L + I VA
Sbjct: 1094 PEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNSGIWSFFFLIVVIFSIVA 1153
Query: 1785 TFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPL 1844
T + E + LI P +G I ++ D+++ G +
Sbjct: 1154 TDLNEY-------GFLGLFFGTMLIPPFTLIGSLFIF---SEISPDSMDYLGASES---- 1199
Query: 1845 SWDLVGRNLFAMAVEGVVFFLITVLIQY---RFFIRPRPVNAKLSPLND----------- 1890
++V L + ++F I ++ + +R PV ++SP ++
Sbjct: 1200 --EIVYLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPV-FRISPRSNAIFPNPEEPEG 1256
Query: 1891 EDEDVRRERQRILDGGGQNDILEI--------------KELTKIYRRKRKPAVDRICVGI 1936
E+ED++ ER R ++ D E K+ +RK+K A + +
Sbjct: 1257 EEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIATRNVSFCV 1316
Query: 1937 PPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDA 1996
GE GLLG NGAGKS+T KM+TGDT T G L S E +GYCPQ +A
Sbjct: 1317 KKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKG----SGGGEPLGFLGYCPQENA 1372
Query: 1997 ITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTA 2056
+ LT R+H+E +A ++G+ + + + L L + S G KRKL
Sbjct: 1373 LWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFV 1432
Query: 2057 MALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEG-RSVVLTSHSMEECEALCTRMA 2115
++++G P VV LDEP+TGMDP+ ++ +W + + R +LT+H M E EA+C R+A
Sbjct: 1433 LSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVCDRVA 1492
Query: 2116 IMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGSVLKEKHRNM 2175
IMV+GR RC+GS+QHLK++FG Y + +++ + ++P+ FP + +E+ ++
Sbjct: 1493 IMVSGRLRCIGSIQHLKSKFGKDYLLEMKLK-NLAQMEPLHAEILRLFPQAAQQERFSSL 1551
Query: 2176 LQYQLP-SSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKD 2232
+ Y+LP + L++ F L K+ +E+YS+SQ+TL+QVF+ +K+Q D +D
Sbjct: 1552 MVYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDLEED 1609
Score = 158 bits (400), Expect = 5e-38
Identities = 160/651 (24%), Positives = 286/651 (43%), Gaps = 78/651 (11%)
Query: 1628 GITAFNHPLNL------TKQQLSEVALMTTSVDVLV-------SICVIFAMSFVPASFVV 1674
G AF +N T + E + T V + + + F + F SF
Sbjct: 177 GFVAFQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFST 236
Query: 1675 FLIQERVSKAKHLQFIS------GVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKS 1728
F+ V+ + Q+I+ G++ +WLS + ++ ATL+ +I +
Sbjct: 237 FIYYVSVNVTQERQYITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMALIV---KSAQ 293
Query: 1729 YVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFV- 1787
V T ++ L LLYG S+ L + S + K P +V+ + +F GI G A +
Sbjct: 294 IVVLTGFVMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPALYTR 353
Query: 1788 LELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWD 1847
L F + L L S F F +G + + ++A +N +
Sbjct: 354 LPAFLEWTL-----CLLSPFA----FTVGMAQLIHLDYDVNSNAHLDSSQNPY------- 397
Query: 1848 LVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVNAKLSPL------------------- 1888
L+ LF + + +++ ++T+ Y I P + SPL
Sbjct: 398 LIIATLFMLVFDTLLYLVLTL---YFDKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVL 454
Query: 1889 -NDEDEDVRRER--QRILDGGGQNDILEIKELTKIYRRK--RKPAVDRICVGIPPGECFG 1943
N+ D D + + + + IK L K Y K R A+ + I G+
Sbjct: 455 ENETDSDPTPNDCFEPVSPEFCGKEAIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITA 514
Query: 1944 LLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSI--LSNIHEVHQNMGYCPQFDAITELL 2001
LLG +GAGK++ +L+G + T G + +++ +++I + + G+CPQ + L
Sbjct: 515 LLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFGFL 574
Query: 2002 TGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIG 2061
T +E++ FA ++G+ EV K + +++L + + A N SGG RKL+ +A++G
Sbjct: 575 TVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAILG 634
Query: 2062 GPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRS---VVLTSHSMEECEALCTRMAIMV 2118
P V+ LDEPT G+DP +R +WN ++KEG+S ++ ++ ++E + L R +
Sbjct: 635 DPQVLLLDEPTAGLDPLSRHRIWN----LLKEGKSDRVILFSTQFIDEADILADRKVFIS 690
Query: 2119 NGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGSVLKEKHRNMLQY 2178
NG+ +C GS LK ++G GY + + + D + + + L + L Y
Sbjct: 691 NGKLKCAGSSLFLKKKWGIGYHLSLHL-NERCDPESITSLVKQHISDAKLTAQSEEKLVY 749
Query: 2179 QLP-SSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDD 2228
LP + ++ L + + IEDY VS TTL++VF+ + D+
Sbjct: 750 ILPLERTNKFPELYRDLDRCSNQ-GIEDYGVSITTLNEVFLKLEGKSTIDE 799
Score = 142 bits (359), Expect = 3e-33
Identities = 95/344 (27%), Positives = 167/344 (48%), Gaps = 51/344 (14%)
Query: 913 KVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIR 972
K+A ++ +G++ LGHNGAGK+TT+ ++TG PT+G + G +
Sbjct: 1306 KIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPLGF-- 1363
Query: 973 QNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQ 1032
LG CPQ N L+ LTV +H+ YA +KGL + + ++ +D +LK+
Sbjct: 1364 --LGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRL-VDALKLQDQLKAPVKT 1420
Query: 1033 LSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELL-LKYRQ-GRTIILSTHH 1090
LS G++RKL L+ +G VV+LDEP+ G+DP ++ +W+++ +R R +L+TH+
Sbjct: 1421 LSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHY 1480
Query: 1091 MDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVS 1150
M EA+ + DR+AI+ G+L C+GS LK++ G Y L + K++
Sbjct: 1481 MAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNL--------------- 1525
Query: 1151 YLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPY 1210
+ + I + +A E + Y LP
Sbjct: 1526 ---------------------------AQMEPLHAEILRLFPQAAQQERFSSLMVYKLPV 1558
Query: 1211 EAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEE 1254
E + + F +++ + Y +S++TLE++FL++++E
Sbjct: 1559 EDVR--PLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKE 1600
>gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo
sapiens]
Length = 1617
Score = 276 bits (707), Expect = 1e-73
Identities = 192/690 (27%), Positives = 336/690 (48%), Gaps = 87/690 (12%)
Query: 592 GFAYLQDVVEQAIIRVLTGTE------KKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMT 645
GF LQ + AII + T T + M+ +P+ I ++ M +
Sbjct: 174 GFVALQTAINTAIIEITTNHPVMEELMSVTAITMKTLPF------ITKNLLHNEMFILFF 227
Query: 646 LAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILK 705
L + I V ++ + K M++MGL +S W SW + + + + + +I+
Sbjct: 228 LLHFSPLVYFISLNVTKERKKSKNLMKMMGLQDSAFWLSWGLIYAGFIFIISIFVTIIIT 287
Query: 706 LGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCV 765
++ + V+F+ ++ + + FL+S L +A L + TL+ +
Sbjct: 288 FTQIIVMTGFMVIFILFFLYGLSLVALVFLMSVLLKKAVLTNLV--VFLLTLFWGCLGFT 345
Query: 766 AWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSV 825
+ + + +L+ ++ SP AF G + GV +F P D + + +
Sbjct: 346 VFYEQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGV----IFPDP-SGDSYTMIATF 400
Query: 826 SMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEESDEKSHPGSNQKRISE 885
SM+L D +Y ++ Y + + P YG R + +F S H +N K I +
Sbjct: 401 SMLLLDGLIYLLLALYFDKILP--YGDERHY-----SPLFFLNSSSCFQHQRTNAKVIEK 453
Query: 886 ICMEEEPT-----------HLKLGVSIQNLVKVYR--DGMKVAVDGLALNFYEGQITSFL 932
E P+ K + I+N+ K Y+ G A+ GL + YEGQIT+ L
Sbjct: 454 EIDAEHPSDDYFEPVAPEFQGKEAIRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAIL 513
Query: 933 GHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRS--EMSTIRQNLGVCPQHNVLFDMLTV 990
GH+GAGK++ ++IL GL PT G+ I K++ ++ IR+ GVCPQ NV FD+LTV
Sbjct: 514 GHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTV 573
Query: 991 EEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVGG 1050
+E++ +A++KG+ K V+ E++++ L++ + + + + LS G +RKL+ + +G
Sbjct: 574 KENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQ-DNLAKHLSEGQKRKLTFGITILGD 632
Query: 1051 SKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDRIAIISHGKLC 1110
++++LDEPT G+DP+SR +W LL + R I+ ST MDEAD+L DR I+S+G+L
Sbjct: 633 PQILLLDEPTTGLDPFSRDQVWSLLRERRADHVILFSTQSMDEADILADRKVIMSNGRLK 692
Query: 1111 CVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSSSDAGLGSD 1170
C GSS+FLK + G GY+L+L + ++
Sbjct: 693 CAGSSMFLKRRWGLGYHLSLHRNEI----------------------------------- 717
Query: 1171 HESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLS 1230
+ I++ I H+ +A+L + +L Y LP E + F +LF ++ D+ S
Sbjct: 718 -------CNPEQITSFITHHIPDAKLKTENKEKLVYTLPLE--RTNTFPDLFSDL-DKCS 767
Query: 1231 DLGISSYGISETTLEEIFLKVAEESGVDAE 1260
D G++ Y IS +TL E+F+K+ +S ++ +
Sbjct: 768 DQGVTGYDISMSTLNEVFMKLEGQSTIEQD 797
Score = 221 bits (562), Expect = 8e-57
Identities = 201/729 (27%), Positives = 342/729 (46%), Gaps = 88/729 (12%)
Query: 1539 VSNTQALPPSQEVNDAIKQMKKHLKLAKDSSADRFLNSLGR---------FMTGLDTKNN 1589
++NT++ + D IK +K L + D F N G ++G
Sbjct: 910 INNTES-----NIEDFIKSLKHQNILLE---VDDFENRNGTDGLSYNGAIIVSGKQKDYR 961
Query: 1590 VKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSHYGITAFNHPLNLTKQQLSEVALM 1649
V N K H +N+I+N +L Q + H I + PL S + L
Sbjct: 962 FSVVCNTKRLHCFPILMNIISNGLL----QMFNHTQHIRIESSPFPL-------SHIGLW 1010
Query: 1650 TTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCN 1709
T D S + + + + I + AK +ISG+ YW + D+
Sbjct: 1011 TGLPDG--SFFLFLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSF 1068
Query: 1710 YVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGW--SITPLMYPASFVFKIPSTAY 1767
+++ L+ +IF + Y+ T+ V AL+++ G+ S+ +Y SF+F+
Sbjct: 1069 FILILLLMYLIFY-IENMQYLLITSQIVFALVIVTPGYAASLVFFIYMISFIFR-KRRKN 1126
Query: 1768 VVLTSVNLFIGINGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQA 1827
L S F +T + + N + ++ ++ ++ L+ + LG V++Q
Sbjct: 1127 SGLWSFYFFFA-----STIMFSITLINHFD-LSILITTMVLVPSYTLLGFKTFLEVRDQ- 1179
Query: 1828 MADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYR-----------FFI 1876
+ F E F + LV F + ++F + ++ + F I
Sbjct: 1180 --EHYREFPEANFELSATDFLV---CFIPYFQTLLFVFVLRCMELKCGKKRMRKDPVFRI 1234
Query: 1877 RPRPVNAKLSPLN--DEDEDVRRERQR--------ILDGGGQNDILEIKELTKIY----- 1921
P+ +AK +P DEDED++ ER R ILD + ++ L K Y
Sbjct: 1235 SPQSRDAKPNPEEPIDEDEDIQTERIRTATALTTSILD---EKPVIIASCLHKEYAGQKK 1291
Query: 1922 ----RRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSI 1977
+RK+K A I + GE GLLG NGAGKSS+ +M++G T T G+ L S
Sbjct: 1292 SCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGCS- 1350
Query: 1978 LSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKY 2037
V ++GYCPQ + + +LT REH+E +A ++G+ + + + L +
Sbjct: 1351 -----SVLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQ 1405
Query: 2038 GEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEG-RS 2096
+ G RKL ++L+G PV+ LDEP+TG+DP ++ +W +VVK R
Sbjct: 1406 LNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERG 1465
Query: 2097 VVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQ 2156
V+LT+H++ E EALC R+AIMV+GR RC+GS+QHLKN+ G Y + +++ ++
Sbjct: 1466 VLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVHT 1525
Query: 2157 DFFGLAFPGSVLKEKHRNMLQYQLP-SSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQ 2215
+ L FP + +E++ ++L Y+LP + + L++ F L K ++E+YS+SQ TL++
Sbjct: 1526 EILKL-FPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKHNFNLEEYSLSQCTLEK 1584
Query: 2216 VFVNFAKDQ 2224
VF+ +K+Q
Sbjct: 1585 VFLELSKEQ 1593
Score = 176 bits (446), Expect = 2e-43
Identities = 166/645 (25%), Positives = 301/645 (46%), Gaps = 80/645 (12%)
Query: 1618 LQKGENPSHYGITAFNHP-----LNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASF 1672
LQ N + IT NHP +++T + + +T ++ + F + F P +
Sbjct: 178 LQTAINTAIIEITT-NHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLHFSPLVY 236
Query: 1673 VVFL-IQERVSKAKHLQFISGVKPVIYWLSNFVWDM--CNYVVPATLVIIIFICFQQKSY 1729
+ L + + K+K+L + G++ +WLS W + ++ ++ + I I F Q
Sbjct: 237 FISLNVTKERKKSKNLMKMMGLQDSAFWLS---WGLIYAGFIFIISIFVTIIITFTQ--I 291
Query: 1730 VSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLE 1789
+ T V+ +L LYG S+ L++ S + K +V+ + LF G G +
Sbjct: 292 IVMTGFMVIFILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFY--- 348
Query: 1790 LFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLV 1849
+ L+ + I F G+I ++K + + F P
Sbjct: 349 -------EQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGVI------FPDPSGDSYT 395
Query: 1850 GRNLFAMAV-EGVVFFLITV----LIQYR--------FFIRP------RPVNAKL----- 1885
F+M + +G+++ L+ + ++ Y FF+ + NAK+
Sbjct: 396 MIATFSMLLLDGLIYLLLALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEI 455
Query: 1886 ---SPLNDEDEDVRRERQRILDGGGQNDILEIKELTKIYRRK--RKPAVDRICVGIPPGE 1940
P +D E V E Q + + I+ + K Y+ K + A+ + I G+
Sbjct: 456 DAEHPSDDYFEPVAPEFQG-------KEAIRIRNVKKEYKGKSGKVEALKGLLFDIYEGQ 508
Query: 1941 CFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFL-NKN-SILSNIHEVHQNMGYCPQFDAIT 1998
+LG +GAGKSS +L G + T G + NKN S + ++ E+ + G CPQF+
Sbjct: 509 ITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQF 568
Query: 1999 ELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMA 2058
++LT +E++ FA ++G+ KEV + + + +L + + A + S G KRKL+ +
Sbjct: 569 DILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGIT 628
Query: 2059 LIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRS---VVLTSHSMEECEALCTRMA 2115
++G P ++ LDEPTTG+DP +R +W S+++E R+ ++ ++ SM+E + L R
Sbjct: 629 ILGDPQILLLDEPTTGLDPFSRDQVW----SLLRERRADHVILFSTQSMDEADILADRKV 684
Query: 2116 IMVNGRFRCLGSVQHLKNRFGDGYTIVV-RIAGSNPDLKPVQDFFGLAFPGSVLKEKHRN 2174
IM NGR +C GS LK R+G GY + + R NP+ + F P + LK +++
Sbjct: 685 IMSNGRLKCAGSSMFLKRRWGLGYHLSLHRNEICNPE--QITSFITHHIPDAKLKTENKE 742
Query: 2175 MLQYQLP-SSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFV 2218
L Y LP ++ +FS L + + + Y +S +TL++VF+
Sbjct: 743 KLVYTLPLERTNTFPDLFSDLDKCSDQ-GVTGYDISMSTLNEVFM 786
Score = 164 bits (414), Expect = 1e-39
Identities = 165/691 (23%), Positives = 297/691 (42%), Gaps = 95/691 (13%)
Query: 593 FAYLQDVVEQAIIRVLTGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSV 652
F L +++ ++++ T+ + ++ P+P ++ + S LF+ L I
Sbjct: 974 FPILMNIISNGLLQMFNHTQH---IRIESSPFPLSHIGLWTGLPDGSFFLFLVLCSISPY 1030
Query: 653 AVIIKGIVYEKEARLKETMRIMGLDNSILWFSWF---ISSLIPLLVSAGLLVVILKLGNL 709
I G + + + K + I GL S W +S I +L+ L+ I + L
Sbjct: 1031 --ITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFILILLLMYLIFYIENMQYL 1088
Query: 710 LPYSDPSVVFVFLSV---FAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVA 766
L S +VF + V +A + ++IS +F + + YF + +
Sbjct: 1089 LITSQ--IVFALVIVTPGYAASLVFFIYMISFIFRKRRKNSGLWSF-YFFFASTIMFSIT 1145
Query: 767 WQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVS 826
++ ++ I +L P G + F +Q ++ E P E F L+ +
Sbjct: 1146 LINHFDLSILITTMVLVPSYTLLGFKTFLEVRDQ------EHYREFP--EANFELSATDF 1197
Query: 827 MMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEESDEKSHPGSNQKRISEI 886
++ F + ++ ++ + G R P + + D K +P +I
Sbjct: 1198 LVCFIPYFQTLLFVFVLRCMELKCGKKRMRKDPVFRIS--PQSRDAKPNPEEPIDEDEDI 1255
Query: 887 CMEEEPTHLKLGVSIQN---------LVKVY---------RDGMKVAVDGLALNFYEGQI 928
E T L SI + L K Y + K+A ++ EG+I
Sbjct: 1256 QTERIRTATALTTSILDEKPVIIASCLHKEYAGQKKSCFSKRKKKIAARNISFCVQEGEI 1315
Query: 929 TSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDML 988
LG NGAGK++++ +++G+ PT+G + G S++ +LG CPQ NVL+ ML
Sbjct: 1316 LGLLGPNGAGKSSSIRMISGITKPTAGEVELKG------CSSVLGHLGYCPQENVLWPML 1369
Query: 989 TVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFV 1048
T+ EH+ YA +KGL + + + ++ L +L +L+ G+ RKL L+ +
Sbjct: 1370 TLREHLEVYAAVKGLRKADARLAIARLVSAFKL-HEQLNVPVQKLTAGITRKLCFVLSLL 1428
Query: 1049 GGSKVVILDEPTAGVDPYSRRGIWELLLKYRQG--RTIILSTHHMDEADVLGDRIAIISH 1106
G S V++LDEP+ G+DP ++ +W+ + + R ++L+TH++ EA+ L DR+AI+
Sbjct: 1429 GNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLAEAEALCDRVAIMVS 1488
Query: 1107 GKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSSSDAG 1166
G+L C+GS LKN+LG Y L L K+
Sbjct: 1489 GRLRCIGSIQHLKNKLGKDYILELKVKE-------------------------------- 1516
Query: 1167 LGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEID 1226
T V+ + I K +A E LTY LP A + FH+++
Sbjct: 1517 ----------TSQVTLVHTEILKLFPQAAGQERYSSLLTYKLP--VADVYPLSQTFHKLE 1564
Query: 1227 DRLSDLGISSYGISETTLEEIFLKVAEESGV 1257
+ + Y +S+ TLE++FL++++E V
Sbjct: 1565 AVKHNFNLEEYSLSQCTLEKVFLELSKEQEV 1595
>gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sapiens]
Length = 1581
Score = 260 bits (665), Expect = 9e-69
Identities = 231/827 (27%), Positives = 368/827 (44%), Gaps = 176/827 (21%)
Query: 592 GFAYLQDVVEQAIIRVLTG---TEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAW 648
GF LQ + AII + T E+ V + M ++ + +T +
Sbjct: 176 GFVALQAAINAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQSGV----------ITDLY 225
Query: 649 IYSVAVIIKGIVY-------EKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLV 701
++S + +Y + R+K M +MGL +S W SW + + + A L
Sbjct: 226 LFSCIISFSSFIYYASVNVTRERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLA 285
Query: 702 VILKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPY 761
++++ + S VVF ++ + + FL+S L ++ L G++ F
Sbjct: 286 LVIRSTQFIILSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLT----GLVVF------ 335
Query: 762 VLCVAWQDYVGFT---------LKIFASLLSPVAFGFGCEYFALFEEQGIGVQWD---NL 809
+L V W +GFT L+ SLLSP AF G Q + + +D N
Sbjct: 336 LLTVFW-GCLGFTSLYRHLPASLEWILSLLSPFAFMLGMA-------QLLHLDYDLNSNA 387
Query: 810 FESPVEEDGFNLTTSVSMML-FDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGE 868
F P DG NL + + ML FDT LY + Y E + P +YG RP F S+W
Sbjct: 388 FPHP--SDGSNLIVATNFMLAFDTCLYLALAIYFEKILPNEYGHRRPPLFFLKSSFW--S 443
Query: 869 ESDEKSHPGSNQKRISEICM----EEEPTHL--KLGVSIQNLVKVYR---DGMKVAVDGL 919
++ + H + ++ E+ P K + I+N+ K Y+ D ++ D L
Sbjct: 444 QTQKTDHVALEDEMDADPSFHDSFEQAPPEFQGKEAIRIRNVTKEYKGKPDKIEALKD-L 502
Query: 920 ALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDI--RSEMSTIRQNLGV 977
+ YEGQIT+ LGH+GAGK+T ++IL+GL PT G+ I + +++ + + GV
Sbjct: 503 VFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGV 562
Query: 978 CPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGM 1037
CPQ NV FD LTV E++ +A++KG+ + V E
Sbjct: 563 CPQSNVQFDFLTVRENLRLFAKIKGILPQEVDKE-------------------------- 596
Query: 1038 QRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVL 1097
+ +LDEPTAG+DP+SR +W LL + + R I+ ST MDEAD+L
Sbjct: 597 ---------------IFLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADIL 641
Query: 1098 GDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDS 1157
DR +S GKL C GSSLFLK + G GY+L+L ++ C +
Sbjct: 642 ADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNEI------CVEEN----------- 684
Query: 1158 VSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGA 1217
I++L+++H+ +A+L +L Y LP E +
Sbjct: 685 -------------------------ITSLVKQHIPDAKLSAKSEGKLIYTLPLE--RTNK 717
Query: 1218 FVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGD 1277
F EL+ ++D DLGI +YG+S TTL E+FLK+ +S ++ SD + G+
Sbjct: 718 FPELYKDLDS-YPDLGIENYGVSMTTLNEVFLKLEGKSTIN--ESDIAI--------LGE 766
Query: 1278 KQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALLWKRL 1337
Q+ + AD + ++ E +LS ++ K + G L +QQ A+ RL
Sbjct: 767 VQA--------EKADDTERLVEME----QVLSSLN-KMRKTIGGVALWRQQICAIARVRL 813
Query: 1338 LIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMY 1384
L + RK A +++ C LV +V + + EL P +Y
Sbjct: 814 LKLKHERKALLALLLILMAGFCPLLVEYTMVKIYQNSYTWELSPHLY 860
Score = 216 bits (551), Expect = 2e-55
Identities = 174/604 (28%), Positives = 296/604 (49%), Gaps = 67/604 (11%)
Query: 1666 SFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQ 1725
S P + I + ++A+ ISG+ P YW + D+ +L ++F+
Sbjct: 993 SSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDV-------SLYFLVFVFIY 1045
Query: 1726 QKSYVSSTNLPVLALLLLL-------YGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIG 1778
SY+S+ +L ++ ++ Y +S+ + Y SF+F+ + S ++
Sbjct: 1046 LMSYISNFEDMLLTIIHIIQIPCAVGYSFSLIFMTYVISFIFR-KGRKNSGIWSFCFYVV 1104
Query: 1779 INGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGEN 1838
SVA F +F ++I I FLI P +G + + + +L F E
Sbjct: 1105 TVFSVAGFAFSIFE----SDIPFIF--TFLIPPATMIG---CLFLSSHLLFSSL--FSEE 1153
Query: 1839 RFVSPLSWDLVGRNLFAMAVEGVVFFLITV-LIQYR-----------FFIRPRPVNAKLS 1886
R D+ +F + + FL T+ ++++ F I PR + +
Sbjct: 1154 RM------DVQPFLVFLIPFLHFIIFLFTLRCLEWKFGKKSMRKDPFFRISPRSSDVCQN 1207
Query: 1887 P--LNDEDEDVRRERQRILD-----GGGQNDILEIKELTKIY---------RRKRKPAVD 1930
P EDEDV+ ER R + + ++ L K Y +RK K A
Sbjct: 1208 PEEPEGEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKNKIATR 1267
Query: 1931 RICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGY 1990
+ + GE GLLG NGAGKS++ K++TGDT T G L S + + +GY
Sbjct: 1268 NVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKG----SGGGDALEFLGY 1323
Query: 1991 CPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNK 2050
CPQ +A+ LT R+H+E +A ++G+ + + + L L + S G K
Sbjct: 1324 CPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIK 1383
Query: 2051 RKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKE-GRSVVLTSHSMEECEA 2109
RKL ++++G P VV LDEP+TGMDP+ ++ +W + + R +LT+H M E EA
Sbjct: 1384 RKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAEA 1443
Query: 2110 LCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGSVLK 2169
+C R+AIMV+GR RC+GS+QHLK++FG Y + +++ + ++P+ FP + +
Sbjct: 1444 VCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVK-NLAQVEPLHAEILRLFPQAARQ 1502
Query: 2170 EKHRNMLQYQLP-SSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDD 2228
E++ +++ Y+LP + LA+ F L + K+ +E+YS+SQ+TL+QVF+ +K+Q D
Sbjct: 1503 ERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKEQELGD 1562
Query: 2229 HLKD 2232
+D
Sbjct: 1563 FEED 1566
Score = 151 bits (381), Expect = 8e-36
Identities = 168/704 (23%), Positives = 297/704 (42%), Gaps = 130/704 (18%)
Query: 593 FAYLQDVVEQAIIRVLTG-----TEKKTGVYM-QQMPYPCYVDDIFLRVMSRSMPLFMTL 646
F L D+V ++ ++ TE+ T + Q P +F V++ S P ++ +
Sbjct: 942 FPVLMDIVSNGLLGMVKPSVHIRTERSTFLENGQDNPIGFLAYIMFWLVLTSSCPPYIAM 1001
Query: 647 AWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKL 706
+ I Y+ AR + +RI GL S WF +L+ + + + V I +
Sbjct: 1002 SSIDD---------YKNRARSQ--LRISGLSPSAYWFG---QALVDVSLYFLVFVFIYLM 1047
Query: 707 GNLLPYSDPSVVFVFLSV------FAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLP 760
+ + D + + + ++ I ++IS +F + + GI F Y+
Sbjct: 1048 SYISNFEDMLLTIIHIIQIPCAVGYSFSLIFMTYVISFIFRKGRKNS---GIWSFCFYVV 1104
Query: 761 YVLCVAWQDYVGFTLKIFAS-------LLSPVAFGFGCEYFA-------LFEEQGIGVQW 806
V VA GF IF S L P A GC + + LF E+ + VQ
Sbjct: 1105 TVFSVA-----GFAFSIFESDIPFIFTFLIPPATMIGCLFLSSHLLFSSLFSEERMDVQP 1159
Query: 807 DNLFESPVEEDGFNLTTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWF 866
+F P + F FL+ + +E F + P++ +S
Sbjct: 1160 FLVFLIP-------------FLHFIIFLFTLRC--LEWKFGKKSMRKDPFFRISPRSSDV 1204
Query: 867 --------GEESDEKSHPGSNQKRISEICMEEEPTHLKLGVSIQNLVKVYRDGM------ 912
GE+ D + ++ +E+P + + + K R G
Sbjct: 1205 CQNPEEPEGEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGK--RKGCFSKRKN 1262
Query: 913 KVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIR 972
K+A ++ +G++ LGHNGAGK+T++ ++TG PT+G + G S
Sbjct: 1263 KIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKG----SGGGDAL 1318
Query: 973 QNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQ 1032
+ LG CPQ N L+ LTV +H+ YA +KGL + + + ++ +D +LKS
Sbjct: 1319 EFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRL-VDALKLQDQLKSPVKT 1377
Query: 1033 LSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELL-LKYRQ-GRTIILSTHH 1090
LS G++RKL L+ +G VV+LDEP+ G+DP ++ +W+ + +R R +L+TH+
Sbjct: 1378 LSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHY 1437
Query: 1091 MDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVS 1150
M EA+ + DR+AI+ G+L C+GS LK++ G Y L + K++
Sbjct: 1438 MAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKNL--------------- 1482
Query: 1151 YLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPY 1210
V + I + +A E + Y LP
Sbjct: 1483 ---------------------------AQVEPLHAEILRLFPQAARQERYSSLMVYKLPV 1515
Query: 1211 EAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEE 1254
E + + F +++ + Y +S++TLE++FL++++E
Sbjct: 1516 EDVQ--PLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKE 1557
Score = 114 bits (284), Expect = 1e-24
Identities = 127/593 (21%), Positives = 242/593 (40%), Gaps = 95/593 (16%)
Query: 1654 DVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVP 1713
D+ + C+I SF+ + V + + KA L + G++ +WLS W +
Sbjct: 223 DLYLFSCIISFSSFIYYASVNVTRERKRMKA--LMTMMGLRDSAFWLS---WGLLYAGFI 277
Query: 1714 ATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSV 1773
+ + + + + ++ + V+ L LLYG S+ L + S + K +V+ +
Sbjct: 278 FIMALFLALVIRSTQFIILSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLL 337
Query: 1774 NLFIGINGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALE 1833
+F G G + + ++ L+ + + F G+ ++ ++
Sbjct: 338 TVFWGCLGFTSLY----------RHLPASLEWILSLLSPFAFMLGMAQLLHLDYDLNS-- 385
Query: 1834 RFGENRFVSPLSW-DLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVNAKLSPL---- 1888
N F P +L+ F +A + ++ + + + I P + PL
Sbjct: 386 ----NAFPHPSDGSNLIVATNFMLAFDTCLYLALAIYFEK---ILPNEYGHRRPPLFFLK 438
Query: 1889 ------NDEDEDVRRERQRILDGGGQN------------DILEIKELTKIYRRK--RKPA 1928
+ + V E + D + + + I+ +TK Y+ K + A
Sbjct: 439 SSFWSQTQKTDHVALEDEMDADPSFHDSFEQAPPEFQGKEAIRIRNVTKEYKGKPDKIEA 498
Query: 1929 VDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFL--NKNSILSNIHEVHQ 1986
+ + I G+ +LG +GAGKS+ +L+G + T+G + NK S ++++ + +
Sbjct: 499 LKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSK 558
Query: 1987 NMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYS 2046
G CPQ + + LT RE++ FA ++G+ +EV K
Sbjct: 559 LTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDK----------------------- 595
Query: 2047 GGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEE 2106
+ LDEPT G+DP +R +WN L K R ++ ++ M+E
Sbjct: 596 -----------------EIFLLDEPTAGLDPFSRHQVWNL-LKERKTDRVILFSTQFMDE 637
Query: 2107 CEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGS 2166
+ L R + G+ +C GS LK ++G GY + +++ + + + P +
Sbjct: 638 ADILADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNEICVE-ENITSLVKQHIPDA 696
Query: 2167 VLKEKHRNMLQYQLP-SSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFV 2218
L K L Y LP + ++ L S L IE+Y VS TTL++VF+
Sbjct: 697 KLSAKSEGKLIYTLPLERTNKFPELYKDL-DSYPDLGIENYGVSMTTLNEVFL 748
>gi|169210363 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 152 bits (385), Expect = 3e-36
Identities = 75/165 (45%), Positives = 108/165 (65%), Gaps = 1/165 (0%)
Query: 2001 LTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALI 2060
+T +E + +A + GV E ++G + L L + + YS GNKR+LSTA+AL+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 2061 GGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNG 2120
G V+FLDEP+TGMDP ARR LWN + G+++V+TSHSMEEC+ALCT +AIMV G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 2121 RFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPG 2165
+F CLGS QHLK++FG+ Y + V++ + L+ + + FPG
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKVKVK-TEDKLEDFKCYVATTFPG 164
Score = 96.7 bits (239), Expect = 2e-19
Identities = 57/157 (36%), Positives = 93/157 (59%), Gaps = 11/157 (7%)
Query: 988 LTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQL----SGGMQRKLSV 1043
+T +E + YAR+ G+SE + + + L S +L+S ++L S G +R+LS
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKC-----LNSLELESHAARLINTYSEGNKRRLST 55
Query: 1044 ALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQ-GRTIILSTHHMDEADVLGDRIA 1102
A+A +G S V+ LDEP+ G+DP +RR +W ++ K R+ G+ I++++H M+E D L +A
Sbjct: 56 AIALMGRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLA 115
Query: 1103 IISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSL 1139
I+ GK C+GS LK++ G Y+ VK E L
Sbjct: 116 IMVQGKFTCLGSPQHLKSKFG-NIYILKVKVKTEDKL 151
>gi|169210679 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 152 bits (385), Expect = 3e-36
Identities = 75/165 (45%), Positives = 108/165 (65%), Gaps = 1/165 (0%)
Query: 2001 LTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALI 2060
+T +E + +A + GV E ++G + L L + + YS GNKR+LSTA+AL+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 2061 GGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNG 2120
G V+FLDEP+TGMDP ARR LWN + G+++V+TSHSMEEC+ALCT +AIMV G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 2121 RFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPG 2165
+F CLGS QHLK++FG+ Y + V++ + L+ + + FPG
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKVKVK-TEDKLEDFKCYVATTFPG 164
Score = 96.7 bits (239), Expect = 2e-19
Identities = 57/157 (36%), Positives = 93/157 (59%), Gaps = 11/157 (7%)
Query: 988 LTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQL----SGGMQRKLSV 1043
+T +E + YAR+ G+SE + + + L S +L+S ++L S G +R+LS
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKC-----LNSLELESHAARLINTYSEGNKRRLST 55
Query: 1044 ALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQ-GRTIILSTHHMDEADVLGDRIA 1102
A+A +G S V+ LDEP+ G+DP +RR +W ++ K R+ G+ I++++H M+E D L +A
Sbjct: 56 AIALMGRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLA 115
Query: 1103 IISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSL 1139
I+ GK C+GS LK++ G Y+ VK E L
Sbjct: 116 IMVQGKFTCLGSPQHLKSKFG-NIYILKVKVKTEDKL 151
>gi|169209894 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 152 bits (385), Expect = 3e-36
Identities = 75/165 (45%), Positives = 108/165 (65%), Gaps = 1/165 (0%)
Query: 2001 LTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALI 2060
+T +E + +A + GV E ++G + L L + + YS GNKR+LSTA+AL+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 2061 GGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNG 2120
G V+FLDEP+TGMDP ARR LWN + G+++V+TSHSMEEC+ALCT +AIMV G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 2121 RFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPG 2165
+F CLGS QHLK++FG+ Y + V++ + L+ + + FPG
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKVKVK-TEDKLEDFKCYVATTFPG 164
Score = 96.7 bits (239), Expect = 2e-19
Identities = 57/157 (36%), Positives = 93/157 (59%), Gaps = 11/157 (7%)
Query: 988 LTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQL----SGGMQRKLSV 1043
+T +E + YAR+ G+SE + + + L S +L+S ++L S G +R+LS
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKC-----LNSLELESHAARLINTYSEGNKRRLST 55
Query: 1044 ALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQ-GRTIILSTHHMDEADVLGDRIA 1102
A+A +G S V+ LDEP+ G+DP +RR +W ++ K R+ G+ I++++H M+E D L +A
Sbjct: 56 AIALMGRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLA 115
Query: 1103 IISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSL 1139
I+ GK C+GS LK++ G Y+ VK E L
Sbjct: 116 IMVQGKFTCLGSPQHLKSKFG-NIYILKVKVKTEDKL 151
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 94.7 bits (234), Expect = 9e-19
Identities = 82/282 (29%), Positives = 143/282 (50%), Gaps = 14/282 (4%)
Query: 891 EPTHLKLGVSIQNLVKVYRDGMKVAV-DGLALNFYEGQITSFLGHNGAGKTTTMSILTGL 949
+P ++K + +N+ Y +V + GL L GQ + +G++G GK+TT+ ++ L
Sbjct: 384 KPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRL 443
Query: 950 FPPTSGTAYILGKDIRS-EMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHV 1008
+ PT G + G+DIR+ + +R+ +GV Q VLF T+ E+I Y R ++
Sbjct: 444 YDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLF-ATTIAENIR-YGRENVTMDEIE 501
Query: 1009 KAEMEQMALD--VGLP---SSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGV 1063
KA E A D + LP + + + +QLSGG ++++++A A V K+++LDE T+ +
Sbjct: 502 KAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSAL 561
Query: 1064 DPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLG 1123
D S + L K R+GRT I+ H + D IA G + G+ L + G
Sbjct: 562 DTESEAVVQVALDKARKGRTTIVIAHRLSTVR-NADVIAGFDDGVIVEKGNHDELMKEKG 620
Query: 1124 TGYYLTLVK---KDVESSLSSCRNSSSTVSYLKKEDSVSQSS 1162
+ L ++ +VE ++ S S + L+ + S+SS
Sbjct: 621 IYFKLVTMQTAGNEVELE-NAADESKSEIDALEMSSNDSRSS 661
Score = 94.0 bits (232), Expect = 2e-18
Identities = 63/224 (28%), Positives = 120/224 (53%), Gaps = 9/224 (4%)
Query: 916 VDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDI-RSEMSTIRQN 974
+ GL+L +GQ + +G +G GK+T + +L + P +G + GK+I R + +R +
Sbjct: 1053 LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAH 1112
Query: 975 LGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDV---GLP---SSKLKS 1028
LG+ Q +LFD ++ E+I + + +S++ + ++ + LP S+K+
Sbjct: 1113 LGIVSQEPILFDC-SIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGD 1171
Query: 1029 KTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILST 1088
K +QLSGG ++++++A A V +++LDE T+ +D S + + E L K R+GRT I+
Sbjct: 1172 KGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIA 1231
Query: 1089 HHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVK 1132
H + D I + +G++ G+ L Q G + + V+
Sbjct: 1232 HRLSTIQ-NADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1274
Score = 60.1 bits (144), Expect = 2e-08
Identities = 51/230 (22%), Positives = 107/230 (46%), Gaps = 11/230 (4%)
Query: 1927 PAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILS-NIHEVH 1985
P + + + + G+ L+G +G GKS+ ++L G L+ I N+ +
Sbjct: 1051 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLR 1110
Query: 1986 QNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNY 2045
++G Q + + E++ + R V ++E+ + + A + KY+
Sbjct: 1111 AHLGIVSQEPILFDCSIA-ENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKV 1169
Query: 2046 -------SGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVV 2098
SGG K++++ A AL+ P ++ LDE T+ +D ++ + + AL +EGR+ +
Sbjct: 1170 GDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQE-ALDKAREGRTCI 1228
Query: 2099 LTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGS 2148
+ +H + + + + NGR + G+ Q L + G +++V AG+
Sbjct: 1229 VIAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGT 1277
Score = 51.6 bits (122), Expect = 9e-06
Identities = 44/189 (23%), Positives = 88/189 (46%), Gaps = 10/189 (5%)
Query: 1923 RKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILS-NI 1981
RK + + + + G+ L+G +G GKS+T +++ T G ++ I + N+
Sbjct: 404 RKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINV 463
Query: 1982 HEVHQNMGYCPQFDAI------TELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLV 2035
+ + +G Q + + GRE+V + + V E K +
Sbjct: 464 RFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTL 523
Query: 2036 KYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGR 2095
GE+ A SGG K++++ A AL+ P ++ LDE T+ +D ++ + AL ++GR
Sbjct: 524 -VGERGA-QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVV-QVALDKARKGR 580
Query: 2096 SVVLTSHSM 2104
+ ++ +H +
Sbjct: 581 TTIVIAHRL 589
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 91.7 bits (226), Expect = 8e-18
Identities = 73/227 (32%), Positives = 115/227 (50%), Gaps = 11/227 (4%)
Query: 918 GLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRS-EMSTIRQNLG 976
GL L GQ + +G +G GK+TT+ ++ L+ P GT I G+DIR+ ++ +R+ +G
Sbjct: 414 GLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIG 473
Query: 977 VCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALD--VGLPS---SKLKSKTS 1031
V Q VLF T+ E+I Y R ++ KA E A + + LP + + + +
Sbjct: 474 VVSQEPVLFST-TIAENIC-YGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGA 531
Query: 1032 QLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHM 1091
QLSGG ++++++A A V K+++LDE T+ +D S + L K R+GRT I+ H +
Sbjct: 532 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRL 591
Query: 1092 DEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESS 1138
D IA G + GS L + G Y LV S
Sbjct: 592 STVR-NADVIAGFEDGVIVEQGSHSELMKK--EGVYFKLVNMQTSGS 635
Score = 83.2 bits (204), Expect = 3e-15
Identities = 61/262 (23%), Positives = 130/262 (49%), Gaps = 17/262 (6%)
Query: 891 EPTHLKLGVSIQNLVKVYRDGMKVAV-DGLALNFYEGQITSFLGHNGAGKTTTMSILTGL 949
+P + ++ +V Y V V GL+L +GQ + +G +G GK+T + +L
Sbjct: 1026 KPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERF 1085
Query: 950 FPPTSGTAYIL-------GKDIRS-EMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLK 1001
+ P +GT ++ G++ + + +R LG+ Q +LFD ++ E+I + +
Sbjct: 1086 YDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDC-SIAENIAYGDNSR 1144
Query: 1002 GLSEKHVKAEMEQMALDVGLPS------SKLKSKTSQLSGGMQRKLSVALAFVGGSKVVI 1055
+S+ + + + + + + +++ K +QLSGG ++++++A A + ++++
Sbjct: 1145 VVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILL 1204
Query: 1056 LDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSS 1115
LDE T+ +D S + + E L K R+GRT I+ H + D I + +G++ G+
Sbjct: 1205 LDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQ-NADLIVVFQNGRVKEHGTH 1263
Query: 1116 LFLKNQLGTGYYLTLVKKDVES 1137
L Q G + + V+ ++
Sbjct: 1264 QQLLAQKGIYFSMVSVQAGTQN 1285
Score = 55.1 bits (131), Expect = 8e-07
Identities = 52/241 (21%), Positives = 106/241 (43%), Gaps = 18/241 (7%)
Query: 1923 RKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLN--------K 1974
R P + + + + G+ L+G +G GKS+ ++L G F++ +
Sbjct: 1046 RANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQ 1105
Query: 1975 NSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGL 2034
+ N+ + +G Q + + E++ + R V + E+ + A +
Sbjct: 1106 EAKKLNVQWLRAQLGIVSQEPILFDCSIA-ENIAYGDNSRVVSQDEIVSAAKAANIHPFI 1164
Query: 2035 VKYGEKY-------AGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCA 2087
KY SGG K++++ A ALI P ++ LDE T+ +D ++ + + A
Sbjct: 1165 ETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQE-A 1223
Query: 2088 LSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAG 2147
L +EGR+ ++ +H + + + + NGR + G+ Q L + G +++V AG
Sbjct: 1224 LDKAREGRTCIVIAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAG 1282
Query: 2148 S 2148
+
Sbjct: 1283 T 1283
Score = 50.4 bits (119), Expect = 2e-05
Identities = 41/176 (23%), Positives = 84/176 (47%), Gaps = 10/176 (5%)
Query: 1936 IPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILS-NIHEVHQNMGYCPQF 1994
+ G+ L+G +G GKS+T +++ G ++ I + N++ + + +G Q
Sbjct: 419 VQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQE 478
Query: 1995 DAI------TELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGG 2048
+ + GR +V + + V E + +K + GE+ A SGG
Sbjct: 479 PVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTL-VGERGA-QLSGG 536
Query: 2049 NKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSM 2104
K++++ A AL+ P ++ LDE T+ +D ++ + AL +EGR+ ++ +H +
Sbjct: 537 QKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHRL 591
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 91.7 bits (226), Expect = 8e-18
Identities = 73/227 (32%), Positives = 115/227 (50%), Gaps = 11/227 (4%)
Query: 918 GLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRS-EMSTIRQNLG 976
GL L GQ + +G +G GK+TT+ ++ L+ P GT I G+DIR+ ++ +R+ +G
Sbjct: 414 GLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIG 473
Query: 977 VCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALD--VGLPS---SKLKSKTS 1031
V Q VLF T+ E+I Y R ++ KA E A + + LP + + + +
Sbjct: 474 VVSQEPVLFST-TIAENIC-YGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGA 531
Query: 1032 QLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHM 1091
QLSGG ++++++A A V K+++LDE T+ +D S + L K R+GRT I+ H +
Sbjct: 532 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRL 591
Query: 1092 DEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESS 1138
D IA G + GS L + G Y LV S
Sbjct: 592 STVR-NADVIAGFEDGVIVEQGSHSELMKK--EGVYFKLVNMQTSGS 635
Score = 88.2 bits (217), Expect = 8e-17
Identities = 61/255 (23%), Positives = 129/255 (50%), Gaps = 10/255 (3%)
Query: 891 EPTHLKLGVSIQNLVKVYRDGMKVAV-DGLALNFYEGQITSFLGHNGAGKTTTMSILTGL 949
+P + ++ +V Y V V GL+L +GQ + +G +G GK+T + +L
Sbjct: 979 KPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERF 1038
Query: 950 FPPTSGTAYILGKDIRS-EMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHV 1008
+ P +GT + G++ + + +R LG+ Q +LFD ++ E+I + + +S+ +
Sbjct: 1039 YDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDC-SIAENIAYGDNSRVVSQDEI 1097
Query: 1009 KAEMEQMALDVGLPS------SKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAG 1062
+ + + + + +++ K +QLSGG ++++++A A + ++++LDE T+
Sbjct: 1098 VSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSA 1157
Query: 1063 VDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQL 1122
+D S + + E L K R+GRT I+ H + D I + +G++ G+ L Q
Sbjct: 1158 LDTESEKVVQEALDKAREGRTCIVIAHRLSTIQ-NADLIVVFQNGRVKEHGTHQQLLAQK 1216
Query: 1123 GTGYYLTLVKKDVES 1137
G + + V+ ++
Sbjct: 1217 GIYFSMVSVQAGTQN 1231
Score = 56.6 bits (135), Expect = 3e-07
Identities = 52/234 (22%), Positives = 103/234 (44%), Gaps = 11/234 (4%)
Query: 1923 RKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILS-NI 1981
R P + + + + G+ L+G +G GKS+ ++L G L+ N+
Sbjct: 999 RANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNV 1058
Query: 1982 HEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKY 2041
+ +G Q + + E++ + R V + E+ + A + KY
Sbjct: 1059 QWLRAQLGIVSQEPILFDCSIA-ENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKY 1117
Query: 2042 -------AGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEG 2094
SGG K++++ A ALI P ++ LDE T+ +D ++ + + AL +EG
Sbjct: 1118 ETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQE-ALDKAREG 1176
Query: 2095 RSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGS 2148
R+ ++ +H + + + + NGR + G+ Q L + G +++V AG+
Sbjct: 1177 RTCIVIAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGT 1229
Score = 50.4 bits (119), Expect = 2e-05
Identities = 41/176 (23%), Positives = 84/176 (47%), Gaps = 10/176 (5%)
Query: 1936 IPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILS-NIHEVHQNMGYCPQF 1994
+ G+ L+G +G GKS+T +++ G ++ I + N++ + + +G Q
Sbjct: 419 VQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQE 478
Query: 1995 DAI------TELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGG 2048
+ + GR +V + + V E + +K + GE+ A SGG
Sbjct: 479 PVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTL-VGERGA-QLSGG 536
Query: 2049 NKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSM 2104
K++++ A AL+ P ++ LDE T+ +D ++ + AL +EGR+ ++ +H +
Sbjct: 537 QKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHRL 591
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 91.7 bits (226), Expect = 8e-18
Identities = 73/227 (32%), Positives = 115/227 (50%), Gaps = 11/227 (4%)
Query: 918 GLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRS-EMSTIRQNLG 976
GL L GQ + +G +G GK+TT+ ++ L+ P GT I G+DIR+ ++ +R+ +G
Sbjct: 414 GLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIG 473
Query: 977 VCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALD--VGLPS---SKLKSKTS 1031
V Q VLF T+ E+I Y R ++ KA E A + + LP + + + +
Sbjct: 474 VVSQEPVLFST-TIAENIC-YGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGA 531
Query: 1032 QLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHM 1091
QLSGG ++++++A A V K+++LDE T+ +D S + L K R+GRT I+ H +
Sbjct: 532 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRL 591
Query: 1092 DEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESS 1138
D IA G + GS L + G Y LV S
Sbjct: 592 STVR-NADVIAGFEDGVIVEQGSHSELMKK--EGVYFKLVNMQTSGS 635
Score = 88.2 bits (217), Expect = 8e-17
Identities = 61/255 (23%), Positives = 129/255 (50%), Gaps = 10/255 (3%)
Query: 891 EPTHLKLGVSIQNLVKVYRDGMKVAV-DGLALNFYEGQITSFLGHNGAGKTTTMSILTGL 949
+P + ++ +V Y V V GL+L +GQ + +G +G GK+T + +L
Sbjct: 1026 KPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERF 1085
Query: 950 FPPTSGTAYILGKDIRS-EMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHV 1008
+ P +GT + G++ + + +R LG+ Q +LFD ++ E+I + + +S+ +
Sbjct: 1086 YDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDC-SIAENIAYGDNSRVVSQDEI 1144
Query: 1009 KAEMEQMALDVGLPS------SKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAG 1062
+ + + + + +++ K +QLSGG ++++++A A + ++++LDE T+
Sbjct: 1145 VSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSA 1204
Query: 1063 VDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQL 1122
+D S + + E L K R+GRT I+ H + D I + +G++ G+ L Q
Sbjct: 1205 LDTESEKVVQEALDKAREGRTCIVIAHRLSTIQ-NADLIVVFQNGRVKEHGTHQQLLAQK 1263
Query: 1123 GTGYYLTLVKKDVES 1137
G + + V+ ++
Sbjct: 1264 GIYFSMVSVQAGTQN 1278
Score = 56.6 bits (135), Expect = 3e-07
Identities = 52/234 (22%), Positives = 103/234 (44%), Gaps = 11/234 (4%)
Query: 1923 RKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILS-NI 1981
R P + + + + G+ L+G +G GKS+ ++L G L+ N+
Sbjct: 1046 RANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNV 1105
Query: 1982 HEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKY 2041
+ +G Q + + E++ + R V + E+ + A + KY
Sbjct: 1106 QWLRAQLGIVSQEPILFDCSIA-ENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKY 1164
Query: 2042 -------AGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEG 2094
SGG K++++ A ALI P ++ LDE T+ +D ++ + + AL +EG
Sbjct: 1165 ETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQE-ALDKAREG 1223
Query: 2095 RSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGS 2148
R+ ++ +H + + + + NGR + G+ Q L + G +++V AG+
Sbjct: 1224 RTCIVIAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGT 1276
Score = 50.4 bits (119), Expect = 2e-05
Identities = 41/176 (23%), Positives = 84/176 (47%), Gaps = 10/176 (5%)
Query: 1936 IPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILS-NIHEVHQNMGYCPQF 1994
+ G+ L+G +G GKS+T +++ G ++ I + N++ + + +G Q
Sbjct: 419 VQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQE 478
Query: 1995 DAI------TELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGG 2048
+ + GR +V + + V E + +K + GE+ A SGG
Sbjct: 479 PVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTL-VGERGA-QLSGG 536
Query: 2049 NKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSM 2104
K++++ A AL+ P ++ LDE T+ +D ++ + AL +EGR+ ++ +H +
Sbjct: 537 QKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHRL 591
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 90.9 bits (224), Expect = 1e-17
Identities = 65/220 (29%), Positives = 116/220 (52%), Gaps = 9/220 (4%)
Query: 916 VDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRS-EMSTIRQN 974
++GL+++ GQ +F+G +G GK+T++ +L + P G I G D + + +R N
Sbjct: 1096 LNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSN 1155
Query: 975 LGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALD---VGLPS---SKLKS 1028
+G+ Q VLF ++ ++I + K + + V A +Q L + LP + + S
Sbjct: 1156 IGIVSQEPVLF-ACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGS 1214
Query: 1029 KTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILST 1088
+ SQLS G ++++++A A V K+++LDE T+ +D S + + L K R+GRT I+
Sbjct: 1215 QGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIA 1274
Query: 1089 HHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYL 1128
H + D IA+++ G + G+ L Q G Y L
Sbjct: 1275 HRLSTIQ-NADIIAVMAQGVVIEKGTHEELMAQKGAYYKL 1313
Score = 86.7 bits (213), Expect = 2e-16
Identities = 78/283 (27%), Positives = 133/283 (46%), Gaps = 16/283 (5%)
Query: 859 PCTKSYWFGEESDEKSHPGSNQKRISEICMEEEPTHL---KLGVSIQNLVKVYRDGMKVA 915
PC +++ G + ++K I + CM E+ L K + N+ Y +V
Sbjct: 378 PCLEAFATGRAAATSIFETIDRKPIID-CMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVK 436
Query: 916 V-DGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRS-EMSTIRQ 973
+ + L + G++T+ +G +GAGK+T + ++ + P G + G DIRS + +R
Sbjct: 437 ILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRD 496
Query: 974 NLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALD--VGLPS---SKLKS 1028
+G+ Q VLF T+ E+I Y R E V+A E A + + LP + +
Sbjct: 497 QIGIVEQEPVLFST-TIAENIR-YGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGE 554
Query: 1029 KTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILST 1088
Q+SGG ++++++A A + K+++LD T+ +D S + E+L K + G TII
Sbjct: 555 GGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVA 614
Query: 1089 HHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLV 1131
H + D I HG G+ L + G Y TLV
Sbjct: 615 HRLSTVRA-ADTIIGFEHGTAVERGTHEELLER--KGVYFTLV 654
Score = 58.9 bits (141), Expect = 5e-08
Identities = 49/228 (21%), Positives = 107/228 (46%), Gaps = 11/228 (4%)
Query: 1923 RKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLN-KNSILSNI 1981
R ++ + V I PG+ +G +G GKS++ ++L +G ++ +S N+
Sbjct: 1090 RPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNV 1149
Query: 1982 HEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKY 2041
+ N+G Q + + + +++++ + +P + V + A ++ EKY
Sbjct: 1150 QFLRSNIGIVSQ-EPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKY 1208
Query: 2042 AGNY-------SGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEG 2094
N S G K++++ A A++ P ++ LDE T+ +D ++ + + AL +EG
Sbjct: 1209 ETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTV-QVALDKAREG 1267
Query: 2095 RSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIV 2142
R+ ++ +H + + +A+M G G+ + L + G Y +V
Sbjct: 1268 RTCIVIAHRLSTIQN-ADIIAVMAQGVVIEKGTHEELMAQKGAYYKLV 1314
Score = 52.4 bits (124), Expect = 5e-06
Identities = 66/296 (22%), Positives = 118/296 (39%), Gaps = 42/296 (14%)
Query: 1936 IPPGECFGLLGVNGAGKSSTFKMLT-------GDTTVTRGDA-FLNKNSILSNIHEVHQ- 1986
I PGE L+G +GAGKS+ +++ G TV D LN + I V Q
Sbjct: 445 IKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQE 504
Query: 1987 ----------NMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVK 2036
N+ Y + + +++ + + + +P++ VGE
Sbjct: 505 PVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGG-------- 556
Query: 2037 YGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRS 2096
G SGG K++++ A ALI P ++ LD T+ +D ++ + LS ++ G +
Sbjct: 557 ------GQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQE-VLSKIQHGHT 609
Query: 2097 VVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSN-----PD 2151
++ +H + A T + +G G+ + L R G +T+V + N D
Sbjct: 610 IISVAHRLSTVRAADTIIG-FEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNEED 668
Query: 2152 LKPV--QDFFGLAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIED 2205
+K D F ++ R ++ + S LS L + K + ED
Sbjct: 669 IKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEED 724
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 87.8 bits (216), Expect = 1e-16
Identities = 60/199 (30%), Positives = 110/199 (55%), Gaps = 9/199 (4%)
Query: 918 GLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRS-EMSTIRQNLG 976
GL+L+ G+ +F+G +G GK+T++ +L L+ P G G D + + +R +
Sbjct: 590 GLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIA 649
Query: 977 VCPQHNVLFDMLTVEEHIWF--YARLKGLSEKHVKAEMEQMALDV-GLP---SSKLKSKT 1030
+ PQ VLF+ ++ E+I + +R+ L E A + + GLP ++++ K
Sbjct: 650 IVPQEPVLFNC-SIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKG 708
Query: 1031 SQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHH 1090
+QLSGG +++L++A A + K+++LDE T+ +D S + + L K R GRT ++ TH
Sbjct: 709 AQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHR 768
Query: 1091 MDEADVLGDRIAIISHGKL 1109
+ A D I ++ +GK+
Sbjct: 769 L-SAIQNADLIVVLHNGKI 786
Score = 61.2 bits (147), Expect = 1e-08
Identities = 52/182 (28%), Positives = 90/182 (49%), Gaps = 10/182 (5%)
Query: 963 DIRS-EMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGL 1021
DIR+ + R ++GV Q VLF T+ +I Y R E+ +A E A D +
Sbjct: 6 DIRALNVRHYRDHIGVVSQEPVLFGT-TISNNIK-YGRDDVTDEEMERAAREANAYDFIM 63
Query: 1022 P-----SSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLL 1076
++ + K +Q+SGG ++++++A A V K++ILDE T+ +D S+ + L
Sbjct: 64 EFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALE 123
Query: 1077 KYRQGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVE 1136
K +GRT I+ H + D I + G L G+ L + G YY ++ +D++
Sbjct: 124 KASKGRTTIVVAHRLSTIR-SADLIVTLKDGMLAEKGAHAELMAKRGL-YYSLVMSQDIK 181
Query: 1137 SS 1138
+
Sbjct: 182 KA 183
Score = 52.0 bits (123), Expect = 7e-06
Identities = 53/233 (22%), Positives = 106/233 (45%), Gaps = 13/233 (5%)
Query: 1912 LEIKELTKIYRRKRKPAVDR-ICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDA 1970
LE +E++ Y + + R + + I G+ +G +G GKS++ ++L +G
Sbjct: 570 LEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQV 629
Query: 1971 -FLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAI 2029
F ++ N+ + + PQ + E++ + R VP E+ + A
Sbjct: 630 LFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIA-ENIAYGDNSRVVPLDEIKEAANAAN 688
Query: 2030 RKLGLVKYGEKY-------AGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRF 2082
+ EKY SGG K++L+ A AL+ P ++ LDE T+ +D + +
Sbjct: 689 IHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKV 748
Query: 2083 LWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQH-LKNR 2134
+ + AL + GR+ ++ +H + + + ++ NG+ + G+ Q L+NR
Sbjct: 749 VQH-ALDKARTGRTCLVVTHRLSAIQN-ADLIVVLHNGKIKEQGTHQELLRNR 799
Score = 43.9 bits (102), Expect = 0.002
Identities = 22/67 (32%), Positives = 41/67 (61%), Gaps = 2/67 (2%)
Query: 2038 GEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSV 2097
GEK A SGG K++++ A AL+ P ++ LDE T+ +D +++ + AL +GR+
Sbjct: 74 GEKGA-QMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAV-QAALEKASKGRTT 131
Query: 2098 VLTSHSM 2104
++ +H +
Sbjct: 132 IVVAHRL 138
>gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7
[Homo sapiens]
Length = 663
Score = 85.5 bits (210), Expect = 5e-16
Identities = 59/202 (29%), Positives = 102/202 (50%), Gaps = 3/202 (1%)
Query: 909 RDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEM 968
+ G K + G++ F G++ + +G +GAGK+T M+IL G + T +L + ++
Sbjct: 91 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAG-YRETGMKGAVLINGLPRDL 149
Query: 969 STIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKS 1028
R+ Q ++L LTV+E + A LK + + EM + L S +
Sbjct: 150 RCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANT 209
Query: 1029 KTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILST 1088
+T LSGG +++L++AL V V+ DEPT+G+D S + L+ QG I+ T
Sbjct: 210 RTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICT 269
Query: 1089 HHMDEADV--LGDRIAIISHGK 1108
H A + L D++ ++S G+
Sbjct: 270 IHQPSAKLFELFDQLYVLSQGQ 291
Score = 71.2 bits (173), Expect = 1e-11
Identities = 49/166 (29%), Positives = 86/166 (51%), Gaps = 4/166 (2%)
Query: 1939 GECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAIT 1998
GE ++G +GAGKS+ +L G A L N + ++ + Y Q D +
Sbjct: 108 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLI-NGLPRDLRCFRKVSCYIMQDDMLL 166
Query: 1999 ELLTGREHVEFFALLRGVPEKEVGK--VGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTA 2056
LT +E + A L+ + EK+ G+ + + + LGL+ G+ SGG +++L+ A
Sbjct: 167 PHLTVQEAMMVSAHLK-LQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIA 225
Query: 2057 MALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSH 2102
+ L+ PPV+F DEPT+G+D + + + + + GRS++ T H
Sbjct: 226 LELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 271
>gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6
[Homo sapiens]
Length = 644
Score = 85.5 bits (210), Expect = 5e-16
Identities = 59/202 (29%), Positives = 102/202 (50%), Gaps = 3/202 (1%)
Query: 909 RDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEM 968
+ G K + G++ F G++ + +G +GAGK+T M+IL G + T +L + ++
Sbjct: 72 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAG-YRETGMKGAVLINGLPRDL 130
Query: 969 STIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKS 1028
R+ Q ++L LTV+E + A LK + + EM + L S +
Sbjct: 131 RCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANT 190
Query: 1029 KTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILST 1088
+T LSGG +++L++AL V V+ DEPT+G+D S + L+ QG I+ T
Sbjct: 191 RTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICT 250
Query: 1089 HHMDEADV--LGDRIAIISHGK 1108
H A + L D++ ++S G+
Sbjct: 251 IHQPSAKLFELFDQLYVLSQGQ 272
Score = 71.2 bits (173), Expect = 1e-11
Identities = 49/166 (29%), Positives = 86/166 (51%), Gaps = 4/166 (2%)
Query: 1939 GECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAIT 1998
GE ++G +GAGKS+ +L G A L N + ++ + Y Q D +
Sbjct: 89 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLI-NGLPRDLRCFRKVSCYIMQDDMLL 147
Query: 1999 ELLTGREHVEFFALLRGVPEKEVGK--VGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTA 2056
LT +E + A L+ + EK+ G+ + + + LGL+ G+ SGG +++L+ A
Sbjct: 148 PHLTVQEAMMVSAHLK-LQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIA 206
Query: 2057 MALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSH 2102
+ L+ PPV+F DEPT+G+D + + + + + GRS++ T H
Sbjct: 207 LELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 252
>gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5
[Homo sapiens]
Length = 668
Score = 85.5 bits (210), Expect = 5e-16
Identities = 59/202 (29%), Positives = 102/202 (50%), Gaps = 3/202 (1%)
Query: 909 RDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEM 968
+ G K + G++ F G++ + +G +GAGK+T M+IL G + T +L + ++
Sbjct: 96 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAG-YRETGMKGAVLINGLPRDL 154
Query: 969 STIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKS 1028
R+ Q ++L LTV+E + A LK + + EM + L S +
Sbjct: 155 RCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANT 214
Query: 1029 KTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILST 1088
+T LSGG +++L++AL V V+ DEPT+G+D S + L+ QG I+ T
Sbjct: 215 RTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICT 274
Query: 1089 HHMDEADV--LGDRIAIISHGK 1108
H A + L D++ ++S G+
Sbjct: 275 IHQPSAKLFELFDQLYVLSQGQ 296
Score = 71.2 bits (173), Expect = 1e-11
Identities = 49/166 (29%), Positives = 86/166 (51%), Gaps = 4/166 (2%)
Query: 1939 GECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAIT 1998
GE ++G +GAGKS+ +L G A L N + ++ + Y Q D +
Sbjct: 113 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLI-NGLPRDLRCFRKVSCYIMQDDMLL 171
Query: 1999 ELLTGREHVEFFALLRGVPEKEVGK--VGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTA 2056
LT +E + A L+ + EK+ G+ + + + LGL+ G+ SGG +++L+ A
Sbjct: 172 PHLTVQEAMMVSAHLK-LQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIA 230
Query: 2057 MALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSH 2102
+ L+ PPV+F DEPT+G+D + + + + + GRS++ T H
Sbjct: 231 LELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 276
>gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3
[Homo sapiens]
Length = 677
Score = 85.5 bits (210), Expect = 5e-16
Identities = 59/202 (29%), Positives = 102/202 (50%), Gaps = 3/202 (1%)
Query: 909 RDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEM 968
+ G K + G++ F G++ + +G +GAGK+T M+IL G + T +L + ++
Sbjct: 105 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAG-YRETGMKGAVLINGLPRDL 163
Query: 969 STIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKS 1028
R+ Q ++L LTV+E + A LK + + EM + L S +
Sbjct: 164 RCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANT 223
Query: 1029 KTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILST 1088
+T LSGG +++L++AL V V+ DEPT+G+D S + L+ QG I+ T
Sbjct: 224 RTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICT 283
Query: 1089 HHMDEADV--LGDRIAIISHGK 1108
H A + L D++ ++S G+
Sbjct: 284 IHQPSAKLFELFDQLYVLSQGQ 305
Score = 71.2 bits (173), Expect = 1e-11
Identities = 49/166 (29%), Positives = 86/166 (51%), Gaps = 4/166 (2%)
Query: 1939 GECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAIT 1998
GE ++G +GAGKS+ +L G A L N + ++ + Y Q D +
Sbjct: 122 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLI-NGLPRDLRCFRKVSCYIMQDDMLL 180
Query: 1999 ELLTGREHVEFFALLRGVPEKEVGK--VGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTA 2056
LT +E + A L+ + EK+ G+ + + + LGL+ G+ SGG +++L+ A
Sbjct: 181 PHLTVQEAMMVSAHLK-LQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIA 239
Query: 2057 MALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSH 2102
+ L+ PPV+F DEPT+G+D + + + + + GRS++ T H
Sbjct: 240 LELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 285
>gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4
[Homo sapiens]
Length = 678
Score = 85.5 bits (210), Expect = 5e-16
Identities = 59/202 (29%), Positives = 102/202 (50%), Gaps = 3/202 (1%)
Query: 909 RDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEM 968
+ G K + G++ F G++ + +G +GAGK+T M+IL G + T +L + ++
Sbjct: 94 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAG-YRETGMKGAVLINGLPRDL 152
Query: 969 STIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKS 1028
R+ Q ++L LTV+E + A LK + + EM + L S +
Sbjct: 153 RCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANT 212
Query: 1029 KTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILST 1088
+T LSGG +++L++AL V V+ DEPT+G+D S + L+ QG I+ T
Sbjct: 213 RTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICT 272
Query: 1089 HHMDEADV--LGDRIAIISHGK 1108
H A + L D++ ++S G+
Sbjct: 273 IHQPSAKLFELFDQLYVLSQGQ 294
Score = 71.2 bits (173), Expect = 1e-11
Identities = 49/166 (29%), Positives = 86/166 (51%), Gaps = 4/166 (2%)
Query: 1939 GECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAIT 1998
GE ++G +GAGKS+ +L G A L N + ++ + Y Q D +
Sbjct: 111 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLI-NGLPRDLRCFRKVSCYIMQDDMLL 169
Query: 1999 ELLTGREHVEFFALLRGVPEKEVGK--VGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTA 2056
LT +E + A L+ + EK+ G+ + + + LGL+ G+ SGG +++L+ A
Sbjct: 170 PHLTVQEAMMVSAHLK-LQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIA 228
Query: 2057 MALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSH 2102
+ L+ PPV+F DEPT+G+D + + + + + GRS++ T H
Sbjct: 229 LELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 274
>gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2
[Homo sapiens]
Length = 666
Score = 85.5 bits (210), Expect = 5e-16
Identities = 59/202 (29%), Positives = 102/202 (50%), Gaps = 3/202 (1%)
Query: 909 RDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEM 968
+ G K + G++ F G++ + +G +GAGK+T M+IL G + T +L + ++
Sbjct: 94 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAG-YRETGMKGAVLINGLPRDL 152
Query: 969 STIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKS 1028
R+ Q ++L LTV+E + A LK + + EM + L S +
Sbjct: 153 RCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANT 212
Query: 1029 KTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILST 1088
+T LSGG +++L++AL V V+ DEPT+G+D S + L+ QG I+ T
Sbjct: 213 RTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICT 272
Query: 1089 HHMDEADV--LGDRIAIISHGK 1108
H A + L D++ ++S G+
Sbjct: 273 IHQPSAKLFELFDQLYVLSQGQ 294
Score = 71.2 bits (173), Expect = 1e-11
Identities = 49/166 (29%), Positives = 86/166 (51%), Gaps = 4/166 (2%)
Query: 1939 GECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAIT 1998
GE ++G +GAGKS+ +L G A L N + ++ + Y Q D +
Sbjct: 111 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLI-NGLPRDLRCFRKVSCYIMQDDMLL 169
Query: 1999 ELLTGREHVEFFALLRGVPEKEVGK--VGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTA 2056
LT +E + A L+ + EK+ G+ + + + LGL+ G+ SGG +++L+ A
Sbjct: 170 PHLTVQEAMMVSAHLK-LQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIA 228
Query: 2057 MALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSH 2102
+ L+ PPV+F DEPT+G+D + + + + + GRS++ T H
Sbjct: 229 LELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 274
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,002,654
Number of Sequences: 37866
Number of extensions: 3889077
Number of successful extensions: 10167
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 78
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 9395
Number of HSP's gapped (non-prelim): 411
length of query: 2261
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2143
effective length of database: 13,779,330
effective search space: 29529104190
effective search space used: 29529104190
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.