BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|21389447 TBC1 domain family, member 20 [Homo sapiens] (403 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|21389447 TBC1 domain family, member 20 [Homo sapiens] 807 0.0 gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] 52 1e-06 gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] 52 1e-06 gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Ho... 47 3e-05 gi|23503283 TBC1 domain family, member 21 [Homo sapiens] 41 0.002 gi|34147456 TBC domain-containing protein kinase-like [Homo sapi... 40 0.004 gi|40068063 TBC1 domain family, member 22B [Homo sapiens] 39 0.006 gi|45597177 TBC1 domain family, member 9B (with GRAM domain) iso... 39 0.006 gi|45597175 TBC1 domain family, member 9B (with GRAM domain) iso... 39 0.006 gi|38570101 TBC1 domain family, member 8B (with GRAM domain) iso... 39 0.008 gi|156231067 TBC1 domain family, member 8 [Homo sapiens] 38 0.014 gi|109638751 ubiquitin specific protease 6 [Homo sapiens] 37 0.041 gi|226693407 TBC1 domain family, member 3H [Homo sapiens] 36 0.054 gi|157502205 TBC1 domain family, member 3G [Homo sapiens] 36 0.054 gi|90577185 TBC1 domain family member 3C [Homo sapiens] 36 0.071 gi|183583565 TBC1 domain family, member 3 [Homo sapiens] 35 0.12 gi|183583567 TBC1 domain family, member 3E [Homo sapiens] 35 0.12 gi|149999613 TBC1 domain family, member 3B [Homo sapiens] 35 0.12 gi|183583563 TBC1 domain family, member 3D [Homo sapiens] 35 0.12 gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo s... 35 0.16 gi|14149985 TBC1 domain family, member 3F [Homo sapiens] 34 0.21 gi|239755792 PREDICTED: hypothetical protein [Homo sapiens] 34 0.27 gi|239750294 PREDICTED: hypothetical protein XP_002347346 [Homo ... 34 0.27 gi|239744603 PREDICTED: hypothetical protein XP_002343238 [Homo ... 34 0.27 gi|197304777 TBC1 domain family, member 5 isoform a [Homo sapiens] 33 0.35 gi|197304775 TBC1 domain family, member 5 isoform b [Homo sapiens] 33 0.35 gi|7661998 TBC1 domain family, member 5 isoform b [Homo sapiens] 33 0.35 gi|148235002 TBC1 domain family, member 26 [Homo sapiens] 33 0.46 gi|87298937 centrosomal protein 110kDa [Homo sapiens] 31 2.3 gi|14150045 calcium/calmodulin-dependent protein kinase 1 alpha ... 30 3.0 >gi|21389447 TBC1 domain family, member 20 [Homo sapiens] Length = 403 Score = 807 bits (2084), Expect = 0.0 Identities = 403/403 (100%), Positives = 403/403 (100%) Query: 1 MALRSAQGDGPTSGHWDGGAEKADFNAKRKKKVAEIHQALNSDPTDVAALRRMAISEGGL 60 MALRSAQGDGPTSGHWDGGAEKADFNAKRKKKVAEIHQALNSDPTDVAALRRMAISEGGL Sbjct: 1 MALRSAQGDGPTSGHWDGGAEKADFNAKRKKKVAEIHQALNSDPTDVAALRRMAISEGGL 60 Query: 61 LTDEIRRKVWPKLLNVNANDPPPISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQRE 120 LTDEIRRKVWPKLLNVNANDPPPISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQRE Sbjct: 61 LTDEIRRKVWPKLLNVNANDPPPISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQRE 120 Query: 121 GLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLATSLVEKLSTHHLRDFMDP 180 GLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLATSLVEKLSTHHLRDFMDP Sbjct: 121 GLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLATSLVEKLSTHHLRDFMDP 180 Query: 181 TMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFALSWLITWFGHVLSDFRHVVRLYD 240 TMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFALSWLITWFGHVLSDFRHVVRLYD Sbjct: 181 TMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFALSWLITWFGHVLSDFRHVVRLYD 240 Query: 241 FFLACHPLMPIYFAAVIVLYREQEVLDCDCDMASVHHLLSQIPQDLPYETLISRAGDLFV 300 FFLACHPLMPIYFAAVIVLYREQEVLDCDCDMASVHHLLSQIPQDLPYETLISRAGDLFV Sbjct: 241 FFLACHPLMPIYFAAVIVLYREQEVLDCDCDMASVHHLLSQIPQDLPYETLISRAGDLFV 300 Query: 301 QFPPSELAREAAAQQQAERTAASTFKDFELASAQQRPDMVLRQRFRGLLRPEDRTKDVLT 360 QFPPSELAREAAAQQQAERTAASTFKDFELASAQQRPDMVLRQRFRGLLRPEDRTKDVLT Sbjct: 301 QFPPSELAREAAAQQQAERTAASTFKDFELASAQQRPDMVLRQRFRGLLRPEDRTKDVLT 360 Query: 361 KPRTNRFVKLAVMGLTVALGAAALAVVKSALEWAPKFQLQLFP 403 KPRTNRFVKLAVMGLTVALGAAALAVVKSALEWAPKFQLQLFP Sbjct: 361 KPRTNRFVKLAVMGLTVALGAAALAVVKSALEWAPKFQLQLFP 403 >gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] Length = 963 Score = 51.6 bits (122), Expect = 1e-06 Identities = 50/201 (24%), Positives = 93/201 (46%), Gaps = 19/201 (9%) Query: 87 KNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQR------EGLQEELIDIILLILERNPQL 140 K L + + +Q+ LD+ R+L P + EG+Q+ L +++L RNP + Sbjct: 698 KALEKQNPASKQIELDLLRTL-------PNNKHYSCPTSEGIQK-LRNVLLAFSWRNPDI 749 Query: 141 HYYQGYHDIVVTFLLVVGERLAT-SLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQV 199 Y QG + +V LL + + A LV + RD+ T+ ++ ++ + Sbjct: 750 GYCQGLNRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEK 809 Query: 200 NPELHDFMQSAEVG-TIFALSW-LITWFGHVLSDFRHVVRLYDFFLACHPLMPIYFAAVI 257 P LH + +V T+ +W L+ + V+SD + +++D FL P + FA + Sbjct: 810 LPRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSDI--LFKIWDSFLYEGPKVIFRFALAL 867 Query: 258 VLYREQEVLDCDCDMASVHHL 278 Y+E+E+L M+ +L Sbjct: 868 FKYKEEEILKLQDSMSIFKYL 888 >gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] Length = 914 Score = 51.6 bits (122), Expect = 1e-06 Identities = 50/201 (24%), Positives = 93/201 (46%), Gaps = 19/201 (9%) Query: 87 KNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQR------EGLQEELIDIILLILERNPQL 140 K L + + +Q+ LD+ R+L P + EG+Q+ L +++L RNP + Sbjct: 698 KALEKQNPASKQIELDLLRTL-------PNNKHYSCPTSEGIQK-LRNVLLAFSWRNPDI 749 Query: 141 HYYQGYHDIVVTFLLVVGERLAT-SLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQV 199 Y QG + +V LL + + A LV + RD+ T+ ++ ++ + Sbjct: 750 GYCQGLNRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEK 809 Query: 200 NPELHDFMQSAEVG-TIFALSW-LITWFGHVLSDFRHVVRLYDFFLACHPLMPIYFAAVI 257 P LH + +V T+ +W L+ + V+SD + +++D FL P + FA + Sbjct: 810 LPRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSDI--LFKIWDSFLYEGPKVIFRFALAL 867 Query: 258 VLYREQEVLDCDCDMASVHHL 278 Y+E+E+L M+ +L Sbjct: 868 FKYKEEEILKLQDSMSIFKYL 888 >gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Homo sapiens] Length = 1266 Score = 47.0 bits (110), Expect = 3e-05 Identities = 69/309 (22%), Positives = 114/309 (36%), Gaps = 28/309 (9%) Query: 61 LTDEIRRKVWPKL---LNVNANDPPPISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEE 117 + + +R ++W L +N A P + M K Y ++ R L R P P Sbjct: 516 IPESMRGELWLLLSGAINEKATHPGYYEDLVEKSMGK-YNLATEEIERDLHRSLPEHPAF 574 Query: 118 QREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLATSLVEKLSTHHLRDF 177 Q E L ++ RNP + Y Q + + LL E A L+ L L D+ Sbjct: 575 QNEMGIAALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAFWLLVALCERMLPDY 634 Query: 178 MDPTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFALSWLITWFGHVLSDFRHVVR 237 + + + P+L+D MQ V + +LSW +T F V+ F V Sbjct: 635 YNTRVVGALVDQGVFEELARDYVPQLYDCMQDLGVISTISLSWFLTLFLSVM-PFESAVV 693 Query: 238 LYDFFLACHPLMPIYFAAVIVLYREQEVLDCDCD----------MASVHHLLSQIPQDLP 287 + D F + A ++ ++L+C D + SV + S +P P Sbjct: 694 VVDCFFYEGIKVIFQLALAVLDANVDKLLNCKDDGEAMTVLGRYLDSVTNKDSTLP---P 750 Query: 288 YETLISRAGDLFVQFPPSELAREAAAQQQAERTAASTFKDFELASAQQRPDMVLRQRFRG 347 L S D +P ++ R ++++ F A M +QR + Sbjct: 751 IPHLHSLLSDDVEPYPEVDIF----------RLIRTSYEKFGTIRADLIEQMRFKQRLKV 800 Query: 348 LLRPEDRTK 356 + ED TK Sbjct: 801 IQTLEDTTK 809 >gi|23503283 TBC1 domain family, member 21 [Homo sapiens] Length = 336 Score = 40.8 bits (94), Expect = 0.002 Identities = 52/243 (21%), Positives = 102/243 (41%), Gaps = 18/243 (7%) Query: 60 LLTDEIRRKVWPKLLNVNANDPPPISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQR 119 L D +RRK + L + P + + R ++ + D+++ + P G + Sbjct: 84 LTVDSMRRKNYKALCQMYEKIQPLLENLH-RNFTETRNNIARDIQKIYDKDPLGNVLIDK 142 Query: 120 EGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLATSLVEKLSTHHLRDFMD 179 + L++ I+LL N Q Y QG+H++++ F L+V T + + Sbjct: 143 KRLEK----ILLLSYVCNTQAEYQQGFHEMMMLFQLMVEHDHETFWLFQFFLQKTEHSCV 198 Query: 180 PTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFAL-SWLITWFGHVLSDFRHVVRL 238 + K+ L+ L +I ++P + ++ G + +L W F F V RL Sbjct: 199 INIGVAKN-LDMLSTLITFLDPVFAEHLKGKGAGAVQSLFPWFCFCFQRAFKSFDDVWRL 257 Query: 239 YDFFLA---CHPLMPIYFAAVIVLYRE---QEVLDCDCDMASVHHLLSQIPQDLPYETLI 292 ++ L C + +++ + RE QE + D + + ++L+ DL + LI Sbjct: 258 WEVLLTGKPCRNFQVLVAYSMLQMVREQVLQESMGGDDILLACNNLI-----DLDADELI 312 Query: 293 SRA 295 S A Sbjct: 313 SAA 315 >gi|34147456 TBC domain-containing protein kinase-like [Homo sapiens] Length = 830 Score = 40.0 bits (92), Expect = 0.004 Identities = 42/185 (22%), Positives = 78/185 (42%), Gaps = 18/185 (9%) Query: 137 NPQLHYYQGYHDIVVTFLLVV--GERLATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMP 194 +P L Y+QG + FL + E LA + + +L +F + + H++ + Sbjct: 476 HPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFF---LKDNSHVIQEYLT 532 Query: 195 IIDQV----NPELHDFMQSAEVGTI---FALSWLITWFGHVLSDFRHVVRLYDFFLACHP 247 + Q+ +PEL + + E+G I +A+ W +T F HV + L+D L + Sbjct: 533 VFSQMIAFHDPELSNHLN--EIGFIPDLYAIPWFLTMFTHVF-PLHKIFHLWDTLLLGNS 589 Query: 248 LMPIYFAAVIVLYREQEVLDCDCDMASVHHLLSQIPQDLPYETLISRAGDLFVQFPPSEL 307 P I+ +L + + L S +P ++ E + + +LF P S Sbjct: 590 SFPFCIGVAILQQLRDRLLANGFNECIL--LFSDLP-EIDIERCVRESINLFCWTPKSAT 646 Query: 308 AREAA 312 R+ A Sbjct: 647 YRQHA 651 >gi|40068063 TBC1 domain family, member 22B [Homo sapiens] Length = 505 Score = 39.3 bits (90), Expect = 0.006 Identities = 50/224 (22%), Positives = 92/224 (41%), Gaps = 33/224 (14%) Query: 87 KNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQLHYYQGY 146 +N Y+Q+ +D+ R+ P +P Q+ +QE I+ + R+P Y QG Sbjct: 256 RNEEHHQDTYRQIHIDIPRT----NPLIPLFQQPLVQEIFERILFIWAIRHPASGYVQGI 311 Query: 147 HDIVVTFLLV-----VGERLATSLVEKLSTHHLRDF-------MDPTMDNTKHILNYLMP 194 +D+V F +V V E + V LS LR M +D + + P Sbjct: 312 NDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDNYTFAQP 371 Query: 195 -----------IIDQVNPELHDFMQSAEVGTI-FALSWLITWFGHVLSDFRHVVRLYDFF 242 ++ +++ ++H+ + EV + FA W+ L R +RL+D + Sbjct: 372 GIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMREL-PLRCTIRLWDTY 430 Query: 243 LA---CHPLMPIYFAAVIVLYREQEVLDCDCDMASVHHLLSQIP 283 + +Y A ++ +E+LD + D + LL +P Sbjct: 431 QSEPEGFSHFHLYVCAAFLIKWRKEILD-EEDFQGLLMLLQNLP 473 >gi|45597177 TBC1 domain family, member 9B (with GRAM domain) isoform b [Homo sapiens] Length = 1233 Score = 39.3 bits (90), Expect = 0.006 Identities = 40/173 (23%), Positives = 66/173 (38%), Gaps = 1/173 (0%) Query: 96 YQQVLLDVRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLL 155 Y ++ R L R P P Q E L ++ RNP + Y Q + + LL Sbjct: 546 YSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLL 605 Query: 156 VVGERLATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTI 215 E A L+ L L D+ + + + P+L + MQ V + Sbjct: 606 YGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISS 665 Query: 216 FALSWLITWFGHVLSDFRHVVRLYDFFLACHPLMPIYFAAVIVLYREQEVLDC 268 +LSW +T F V+ F V + D F + + A ++ +++L C Sbjct: 666 ISLSWFLTLFLSVM-PFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGC 717 >gi|45597175 TBC1 domain family, member 9B (with GRAM domain) isoform a [Homo sapiens] Length = 1250 Score = 39.3 bits (90), Expect = 0.006 Identities = 40/173 (23%), Positives = 66/173 (38%), Gaps = 1/173 (0%) Query: 96 YQQVLLDVRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLL 155 Y ++ R L R P P Q E L ++ RNP + Y Q + + LL Sbjct: 546 YSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLL 605 Query: 156 VVGERLATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTI 215 E A L+ L L D+ + + + P+L + MQ V + Sbjct: 606 YGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISS 665 Query: 216 FALSWLITWFGHVLSDFRHVVRLYDFFLACHPLMPIYFAAVIVLYREQEVLDC 268 +LSW +T F V+ F V + D F + + A ++ +++L C Sbjct: 666 ISLSWFLTLFLSVM-PFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGC 717 >gi|38570101 TBC1 domain family, member 8B (with GRAM domain) isoform a [Homo sapiens] Length = 1120 Score = 38.9 bits (89), Expect = 0.008 Identities = 40/174 (22%), Positives = 66/174 (37%), Gaps = 1/174 (0%) Query: 102 DVRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERL 161 ++ R LRR P P Q + L ++ RNP++ Y Q + + LL E Sbjct: 531 EIERDLRRSLPEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEE 590 Query: 162 ATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFALSWL 221 A L+ + L D+ + + +I P+L + M + +LSW Sbjct: 591 AFWLLVAVCERMLPDYFNRRIIGALVDQAVFEELIRDHLPQLTEHMTDMTFFSSVSLSWF 650 Query: 222 ITWFGHVLSDFRHVVRLYDFFLACHPLMPIYFAAVIVLYREQEVLDCDCDMASV 275 +T F VL V + D F + I+ Y ++L C D +V Sbjct: 651 LTLFISVL-PIESAVNVVDCFFYDGIKAILQLGLAILDYNLDKLLTCKDDAEAV 703 >gi|156231067 TBC1 domain family, member 8 [Homo sapiens] Length = 1140 Score = 38.1 bits (87), Expect = 0.014 Identities = 30/124 (24%), Positives = 49/124 (39%) Query: 102 DVRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERL 161 ++ R L R P P Q E L ++ RNP++ Y Q + + LL E Sbjct: 549 EIERDLHRSLPEHPAFQNETGIAALRRVLTAYAHRNPKIGYCQSMNILTSVLLLYTKEEE 608 Query: 162 ATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFALSWL 221 A L+ + L D+ + + + + +I PEL + M +LSW Sbjct: 609 AFWLLVAVCERMLPDYFNHRVIGAQVDQSVFEELIKGHLPELAEHMNDLSALASVSLSWF 668 Query: 222 ITWF 225 +T F Sbjct: 669 LTLF 672 >gi|109638751 ubiquitin specific protease 6 [Homo sapiens] Length = 1406 Score = 36.6 bits (83), Expect = 0.041 Identities = 41/145 (28%), Positives = 63/145 (43%), Gaps = 17/145 (11%) Query: 65 IRRKVWPKLLNVNA---NDPP--PISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQR 119 IR VW LLN+ +P I + ++ S+ + LDVR +LR ++ Sbjct: 105 IRGPVWSVLLNIQEIKLKNPGRYQIMKERGKRSSEHIHHIDLDVRTTLRNHV--FFRDRY 162 Query: 120 EGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLA-TSLVEKLST--HHLRD 176 Q EL I+L E NP++ Y + I FLL + E A +LV+ L++ H L Sbjct: 163 GAKQRELFYILLAYSEYNPEVGYCRDLSHITALFLLYLPEEDAFWALVQLLASERHSLPG 222 Query: 177 FMDPT-------MDNTKHILNYLMP 194 F P D +H++ P Sbjct: 223 FHSPNGGTVQGLQDQQEHVVPKSQP 247 >gi|226693407 TBC1 domain family, member 3H [Homo sapiens] Length = 549 Score = 36.2 bits (82), Expect = 0.054 Identities = 41/146 (28%), Positives = 67/146 (45%), Gaps = 19/146 (13%) Query: 65 IRRKVWPKLLNVNA---NDPP--PISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQR 119 IR +W LLN+ +P I + ++ S+ Q++ D+ +LR+ M R Sbjct: 106 IRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKH---MFFRDR 162 Query: 120 EGL-QEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLA-TSLVEKLST--HHLR 175 G Q EL+ I+L E NP++ Y + I FLL + E A +LV+ L++ H L+ Sbjct: 163 YGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQ 222 Query: 176 DFMDPT-------MDNTKHILNYLMP 194 F P D +H++ P Sbjct: 223 GFHSPNGGTVQGLQDQQEHVVATSQP 248 >gi|157502205 TBC1 domain family, member 3G [Homo sapiens] Length = 549 Score = 36.2 bits (82), Expect = 0.054 Identities = 41/146 (28%), Positives = 67/146 (45%), Gaps = 19/146 (13%) Query: 65 IRRKVWPKLLNVNA---NDPP--PISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQR 119 IR +W LLN+ +P I + ++ S+ Q++ D+ +LR+ M R Sbjct: 106 IRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKH---MFFRDR 162 Query: 120 EGL-QEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLA-TSLVEKLST--HHLR 175 G Q EL+ I+L E NP++ Y + I FLL + E A +LV+ L++ H L+ Sbjct: 163 YGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQ 222 Query: 176 DFMDPT-------MDNTKHILNYLMP 194 F P D +H++ P Sbjct: 223 GFHSPNGGTVQGLQDQQEHVVATSQP 248 >gi|90577185 TBC1 domain family member 3C [Homo sapiens] Length = 549 Score = 35.8 bits (81), Expect = 0.071 Identities = 38/125 (30%), Positives = 61/125 (48%), Gaps = 12/125 (9%) Query: 65 IRRKVWPKLLNVNA---NDPP--PISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQR 119 IR +W LLN+ +P I + ++ S+ Q++ D+ +LR+ M R Sbjct: 106 IRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKH---MFFRDR 162 Query: 120 EGL-QEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLA-TSLVEKLST--HHLR 175 G Q EL+ I+L E NP++ Y + I FLL + E A +LV+ L++ H L+ Sbjct: 163 YGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQ 222 Query: 176 DFMDP 180 F P Sbjct: 223 GFHSP 227 >gi|183583565 TBC1 domain family, member 3 [Homo sapiens] Length = 549 Score = 35.0 bits (79), Expect = 0.12 Identities = 41/146 (28%), Positives = 67/146 (45%), Gaps = 19/146 (13%) Query: 65 IRRKVWPKLLNVNA---NDPP--PISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQR 119 IR +W LLN+ +P I + ++ S+ Q++ DV +LR+ + R Sbjct: 106 IRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKH---IFFRDR 162 Query: 120 EGL-QEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLA-TSLVEKLST--HHLR 175 G Q EL+ I+L E NP++ Y + I FLL + E A +LV+ L++ H L+ Sbjct: 163 YGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQ 222 Query: 176 DFMDPT-------MDNTKHILNYLMP 194 F P D +H++ P Sbjct: 223 GFHSPNGGTVQGLQDQQEHVVATSQP 248 >gi|183583567 TBC1 domain family, member 3E [Homo sapiens] Length = 549 Score = 35.0 bits (79), Expect = 0.12 Identities = 41/146 (28%), Positives = 67/146 (45%), Gaps = 19/146 (13%) Query: 65 IRRKVWPKLLNVNA---NDPP--PISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQR 119 IR +W LLN+ +P I + ++ S+ Q++ DV +LR+ + R Sbjct: 106 IRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKH---IFFRDR 162 Query: 120 EGL-QEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLA-TSLVEKLST--HHLR 175 G Q EL+ I+L E NP++ Y + I FLL + E A +LV+ L++ H L+ Sbjct: 163 YGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQ 222 Query: 176 DFMDPT-------MDNTKHILNYLMP 194 F P D +H++ P Sbjct: 223 GFHSPNGGTVQGLQDQQEHVVATSQP 248 >gi|149999613 TBC1 domain family, member 3B [Homo sapiens] Length = 549 Score = 35.0 bits (79), Expect = 0.12 Identities = 38/125 (30%), Positives = 60/125 (48%), Gaps = 12/125 (9%) Query: 65 IRRKVWPKLLNVNA---NDPP--PISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQR 119 IR +W LLN+ +P I + ++ S+ Q++ D+ +LR+ M R Sbjct: 106 IRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKH---MFFRDR 162 Query: 120 EGL-QEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLA-TSLVEKLST--HHLR 175 G Q EL+ I+L E NP++ Y + I FLL E A +LV+ L++ H L+ Sbjct: 163 YGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYFPEEDAFWALVQLLASERHSLQ 222 Query: 176 DFMDP 180 F P Sbjct: 223 GFHSP 227 >gi|183583563 TBC1 domain family, member 3D [Homo sapiens] Length = 549 Score = 35.0 bits (79), Expect = 0.12 Identities = 41/146 (28%), Positives = 67/146 (45%), Gaps = 19/146 (13%) Query: 65 IRRKVWPKLLNVNA---NDPP--PISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQR 119 IR +W LLN+ +P I + ++ S+ Q++ DV +LR+ + R Sbjct: 106 IRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKH---IFFRDR 162 Query: 120 EGL-QEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLA-TSLVEKLST--HHLR 175 G Q EL+ I+L E NP++ Y + I FLL + E A +LV+ L++ H L+ Sbjct: 163 YGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQ 222 Query: 176 DFMDPT-------MDNTKHILNYLMP 194 F P D +H++ P Sbjct: 223 GFHSPNGGTVQGLQDQQEHVVATSQP 248 >gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo sapiens] Length = 486 Score = 34.7 bits (78), Expect = 0.16 Identities = 29/108 (26%), Positives = 48/108 (44%), Gaps = 11/108 (10%) Query: 21 EKADFNAKRKKKVAEIHQALNSDPTDVAALRRMAISEGGLLTDEIRRKVWPKLLNVNAND 80 EKA A+R+++ + + P V A+ A+ L +I + WP + Sbjct: 256 EKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAP--LPKKISSEAWPPV------G 307 Query: 81 PPPISGKNLRQMSKDYQQVLLDVRRSL---RRFPPGMPEEQREGLQEE 125 PP S + S+++ LL +R++L PP +P EGLQ E Sbjct: 308 TPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVE 355 >gi|14149985 TBC1 domain family, member 3F [Homo sapiens] Length = 549 Score = 34.3 bits (77), Expect = 0.21 Identities = 41/146 (28%), Positives = 67/146 (45%), Gaps = 19/146 (13%) Query: 65 IRRKVWPKLLN---VNANDPP--PISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQR 119 IR +W LLN + +P I + ++ S+ Q++ DV +LR+ + R Sbjct: 106 IRGPMWSVLLNTEEMKLKNPGRYQIMKEKGKKSSEHIQRIDRDVSGTLRKH---IFFRDR 162 Query: 120 EGL-QEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLA-TSLVEKLST--HHLR 175 G Q EL+ I+L E NP++ Y + I FLL + E A +LV+ L++ H L+ Sbjct: 163 YGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQ 222 Query: 176 DFMDPT-------MDNTKHILNYLMP 194 F P D +H++ P Sbjct: 223 GFHSPNGGTVQGLQDQQEHVVATSQP 248 >gi|239755792 PREDICTED: hypothetical protein [Homo sapiens] Length = 257 Score = 33.9 bits (76), Expect = 0.27 Identities = 35/122 (28%), Positives = 52/122 (42%), Gaps = 9/122 (7%) Query: 57 EGGLLTDEIRRKVWPKLLNVNANDPPPIS----GKNLRQMSKDYQQVLLDVRRSLRRFPP 112 EGGLL E+ RK P + + P G++L Q + QVL +R P Sbjct: 28 EGGLLPPELGRKKTPGDFLAHRHGRVPHQEARLGQHLAQALEQVLQVLQVASPGVRTIPG 87 Query: 113 GMPEEQREGLQEELIDIILLILERNPQLHYYQGYH--DIVVTFLLVVGERLATSLVEKLS 170 +PE G+ ++ + +L L+ G H + V T+ +VVG LA V K Sbjct: 88 DVPE---AGIHDDQVGGVLARLQLFQDGLEVIGVHAGEEVKTYQMVVGAELADLTVVKAV 144 Query: 171 TH 172 H Sbjct: 145 VH 146 >gi|239750294 PREDICTED: hypothetical protein XP_002347346 [Homo sapiens] Length = 257 Score = 33.9 bits (76), Expect = 0.27 Identities = 35/122 (28%), Positives = 52/122 (42%), Gaps = 9/122 (7%) Query: 57 EGGLLTDEIRRKVWPKLLNVNANDPPPIS----GKNLRQMSKDYQQVLLDVRRSLRRFPP 112 EGGLL E+ RK P + + P G++L Q + QVL +R P Sbjct: 28 EGGLLPPELGRKKTPGDFLAHRHGRVPHQEARLGQHLAQALEQVLQVLQVASPGVRTIPG 87 Query: 113 GMPEEQREGLQEELIDIILLILERNPQLHYYQGYH--DIVVTFLLVVGERLATSLVEKLS 170 +PE G+ ++ + +L L+ G H + V T+ +VVG LA V K Sbjct: 88 DVPE---AGIHDDQVGGVLARLQLFQDGLEVIGVHAGEEVKTYQMVVGAELADLTVVKAV 144 Query: 171 TH 172 H Sbjct: 145 VH 146 >gi|239744603 PREDICTED: hypothetical protein XP_002343238 [Homo sapiens] Length = 257 Score = 33.9 bits (76), Expect = 0.27 Identities = 35/122 (28%), Positives = 52/122 (42%), Gaps = 9/122 (7%) Query: 57 EGGLLTDEIRRKVWPKLLNVNANDPPPIS----GKNLRQMSKDYQQVLLDVRRSLRRFPP 112 EGGLL E+ RK P + + P G++L Q + QVL +R P Sbjct: 28 EGGLLPPELGRKKTPGDFLAHRHGRVPHQEARLGQHLAQALEQVLQVLQVASPGVRTIPG 87 Query: 113 GMPEEQREGLQEELIDIILLILERNPQLHYYQGYH--DIVVTFLLVVGERLATSLVEKLS 170 +PE G+ ++ + +L L+ G H + V T+ +VVG LA V K Sbjct: 88 DVPE---AGIHDDQVGGVLARLQLFQDGLEVIGVHAGEEVKTYQMVVGAELADLTVVKAV 144 Query: 171 TH 172 H Sbjct: 145 VH 146 >gi|197304777 TBC1 domain family, member 5 isoform a [Homo sapiens] Length = 817 Score = 33.5 bits (75), Expect = 0.35 Identities = 15/55 (27%), Positives = 30/55 (54%) Query: 103 VRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVV 157 + + ++R P M Q+E +++ L D++ N QL Y QG H+++ + V+ Sbjct: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVL 217 >gi|197304775 TBC1 domain family, member 5 isoform b [Homo sapiens] Length = 795 Score = 33.5 bits (75), Expect = 0.35 Identities = 15/55 (27%), Positives = 30/55 (54%) Query: 103 VRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVV 157 + + ++R P M Q+E +++ L D++ N QL Y QG H+++ + V+ Sbjct: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVL 217 >gi|7661998 TBC1 domain family, member 5 isoform b [Homo sapiens] Length = 795 Score = 33.5 bits (75), Expect = 0.35 Identities = 15/55 (27%), Positives = 30/55 (54%) Query: 103 VRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVV 157 + + ++R P M Q+E +++ L D++ N QL Y QG H+++ + V+ Sbjct: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVL 217 >gi|148235002 TBC1 domain family, member 26 [Homo sapiens] Length = 250 Score = 33.1 bits (74), Expect = 0.46 Identities = 31/138 (22%), Positives = 66/138 (47%), Gaps = 9/138 (6%) Query: 28 KRKKKVAEIHQALNSDPTDVAALRRMAISEGGLLTDEIRRKVWPKLLNVNA-NDPPPISG 86 +++ K Q + +D T + ++++ ++ +R + W LL+++ P Sbjct: 69 RKESKRTNKWQKMLADWTKYRSTKKLSQRVYKVIPLAVRGRAWSLLLDIDRIKSQNPGKY 128 Query: 87 KNLRQMSKDYQQVL----LDVRRSLRRFPPGMPEEQREGL-QEELIDIILLILERNPQLH 141 K +++ K +++ LDV +L++ M QR G+ Q+EL DI++ NP++ Sbjct: 129 KVMKEKGKRSSRIIHCIQLDVSHTLQKH---MMFIQRFGVKQQELCDILVAYSAYNPEVG 185 Query: 142 YYQGYHDIVVTFLLVVGE 159 Y++ I LL + E Sbjct: 186 YHRDLSRITAILLLCLPE 203 >gi|87298937 centrosomal protein 110kDa [Homo sapiens] Length = 2325 Score = 30.8 bits (68), Expect = 2.3 Identities = 21/95 (22%), Positives = 42/95 (44%), Gaps = 16/95 (16%) Query: 22 KADFNAKRKKKVAEIHQALNSDPTDVAALRR----------------MAISEGGLLTDEI 65 KA F+ +++++ +E+H L D L++ + E DE+ Sbjct: 757 KAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDEL 816 Query: 66 RRKVWPKLLNVNANDPPPISGKNLRQMSKDYQQVL 100 RRK+ +N + P + GK+L + K + ++L Sbjct: 817 RRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEIL 851 >gi|14150045 calcium/calmodulin-dependent protein kinase 1 alpha isoform a [Homo sapiens] Length = 505 Score = 30.4 bits (67), Expect = 3.0 Identities = 15/40 (37%), Positives = 25/40 (62%), Gaps = 2/40 (5%) Query: 100 LLDVRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQ 139 +L + R ++ P PEE + EEL D+IL +L++NP+ Sbjct: 358 ILALHRKIKNEPVVFPEEPE--ISEELKDLILKMLDKNPE 395 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.323 0.137 0.410 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,106,624 Number of Sequences: 37866 Number of extensions: 649921 Number of successful extensions: 1685 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 6 Number of HSP's successfully gapped in prelim test: 32 Number of HSP's that attempted gapping in prelim test: 1674 Number of HSP's gapped (non-prelim): 42 length of query: 403 length of database: 18,247,518 effective HSP length: 105 effective length of query: 298 effective length of database: 14,271,588 effective search space: 4252933224 effective search space used: 4252933224 T: 11 A: 40 X1: 16 ( 7.5 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (22.0 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.