Guide to the Human Genome
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Search of human proteins with 21389447

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21389447 TBC1 domain family, member 20 [Homo sapiens]
         (403 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21389447 TBC1 domain family, member 20 [Homo sapiens]              807   0.0  
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]    52   1e-06
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]    52   1e-06
gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Ho...    47   3e-05
gi|23503283 TBC1 domain family, member 21 [Homo sapiens]               41   0.002
gi|34147456 TBC domain-containing protein kinase-like [Homo sapi...    40   0.004
gi|40068063 TBC1 domain family, member 22B [Homo sapiens]              39   0.006
gi|45597177 TBC1 domain family, member 9B (with GRAM domain) iso...    39   0.006
gi|45597175 TBC1 domain family, member 9B (with GRAM domain) iso...    39   0.006
gi|38570101 TBC1 domain family, member 8B (with GRAM domain) iso...    39   0.008
gi|156231067 TBC1 domain family, member 8 [Homo sapiens]               38   0.014
gi|109638751 ubiquitin specific protease 6 [Homo sapiens]              37   0.041
gi|226693407 TBC1 domain family, member 3H [Homo sapiens]              36   0.054
gi|157502205 TBC1 domain family, member 3G [Homo sapiens]              36   0.054
gi|90577185 TBC1 domain family member 3C [Homo sapiens]                36   0.071
gi|183583565 TBC1 domain family, member 3 [Homo sapiens]               35   0.12 
gi|183583567 TBC1 domain family, member 3E [Homo sapiens]              35   0.12 
gi|149999613 TBC1 domain family, member 3B [Homo sapiens]              35   0.12 
gi|183583563 TBC1 domain family, member 3D [Homo sapiens]              35   0.12 
gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo s...    35   0.16 
gi|14149985 TBC1 domain family, member 3F [Homo sapiens]               34   0.21 
gi|239755792 PREDICTED: hypothetical protein [Homo sapiens]            34   0.27 
gi|239750294 PREDICTED: hypothetical protein XP_002347346 [Homo ...    34   0.27 
gi|239744603 PREDICTED: hypothetical protein XP_002343238 [Homo ...    34   0.27 
gi|197304777 TBC1 domain family, member 5 isoform a [Homo sapiens]     33   0.35 
gi|197304775 TBC1 domain family, member 5 isoform b [Homo sapiens]     33   0.35 
gi|7661998 TBC1 domain family, member 5 isoform b [Homo sapiens]       33   0.35 
gi|148235002 TBC1 domain family, member 26 [Homo sapiens]              33   0.46 
gi|87298937 centrosomal protein 110kDa [Homo sapiens]                  31   2.3  
gi|14150045 calcium/calmodulin-dependent protein kinase 1 alpha ...    30   3.0  

>gi|21389447 TBC1 domain family, member 20 [Homo sapiens]
          Length = 403

 Score =  807 bits (2084), Expect = 0.0
 Identities = 403/403 (100%), Positives = 403/403 (100%)

Query: 1   MALRSAQGDGPTSGHWDGGAEKADFNAKRKKKVAEIHQALNSDPTDVAALRRMAISEGGL 60
           MALRSAQGDGPTSGHWDGGAEKADFNAKRKKKVAEIHQALNSDPTDVAALRRMAISEGGL
Sbjct: 1   MALRSAQGDGPTSGHWDGGAEKADFNAKRKKKVAEIHQALNSDPTDVAALRRMAISEGGL 60

Query: 61  LTDEIRRKVWPKLLNVNANDPPPISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQRE 120
           LTDEIRRKVWPKLLNVNANDPPPISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQRE
Sbjct: 61  LTDEIRRKVWPKLLNVNANDPPPISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQRE 120

Query: 121 GLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLATSLVEKLSTHHLRDFMDP 180
           GLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLATSLVEKLSTHHLRDFMDP
Sbjct: 121 GLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLATSLVEKLSTHHLRDFMDP 180

Query: 181 TMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFALSWLITWFGHVLSDFRHVVRLYD 240
           TMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFALSWLITWFGHVLSDFRHVVRLYD
Sbjct: 181 TMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFALSWLITWFGHVLSDFRHVVRLYD 240

Query: 241 FFLACHPLMPIYFAAVIVLYREQEVLDCDCDMASVHHLLSQIPQDLPYETLISRAGDLFV 300
           FFLACHPLMPIYFAAVIVLYREQEVLDCDCDMASVHHLLSQIPQDLPYETLISRAGDLFV
Sbjct: 241 FFLACHPLMPIYFAAVIVLYREQEVLDCDCDMASVHHLLSQIPQDLPYETLISRAGDLFV 300

Query: 301 QFPPSELAREAAAQQQAERTAASTFKDFELASAQQRPDMVLRQRFRGLLRPEDRTKDVLT 360
           QFPPSELAREAAAQQQAERTAASTFKDFELASAQQRPDMVLRQRFRGLLRPEDRTKDVLT
Sbjct: 301 QFPPSELAREAAAQQQAERTAASTFKDFELASAQQRPDMVLRQRFRGLLRPEDRTKDVLT 360

Query: 361 KPRTNRFVKLAVMGLTVALGAAALAVVKSALEWAPKFQLQLFP 403
           KPRTNRFVKLAVMGLTVALGAAALAVVKSALEWAPKFQLQLFP
Sbjct: 361 KPRTNRFVKLAVMGLTVALGAAALAVVKSALEWAPKFQLQLFP 403


>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
          Length = 963

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 50/201 (24%), Positives = 93/201 (46%), Gaps = 19/201 (9%)

Query: 87  KNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQR------EGLQEELIDIILLILERNPQL 140
           K L + +   +Q+ LD+ R+L       P  +       EG+Q+ L +++L    RNP +
Sbjct: 698 KALEKQNPASKQIELDLLRTL-------PNNKHYSCPTSEGIQK-LRNVLLAFSWRNPDI 749

Query: 141 HYYQGYHDIVVTFLLVVGERLAT-SLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQV 199
            Y QG + +V   LL + +  A   LV  +     RD+   T+  ++        ++ + 
Sbjct: 750 GYCQGLNRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEK 809

Query: 200 NPELHDFMQSAEVG-TIFALSW-LITWFGHVLSDFRHVVRLYDFFLACHPLMPIYFAAVI 257
            P LH   +  +V  T+   +W L+ +   V+SD   + +++D FL   P +   FA  +
Sbjct: 810 LPRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSDI--LFKIWDSFLYEGPKVIFRFALAL 867

Query: 258 VLYREQEVLDCDCDMASVHHL 278
             Y+E+E+L     M+   +L
Sbjct: 868 FKYKEEEILKLQDSMSIFKYL 888


>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
          Length = 914

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 50/201 (24%), Positives = 93/201 (46%), Gaps = 19/201 (9%)

Query: 87  KNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQR------EGLQEELIDIILLILERNPQL 140
           K L + +   +Q+ LD+ R+L       P  +       EG+Q+ L +++L    RNP +
Sbjct: 698 KALEKQNPASKQIELDLLRTL-------PNNKHYSCPTSEGIQK-LRNVLLAFSWRNPDI 749

Query: 141 HYYQGYHDIVVTFLLVVGERLAT-SLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQV 199
            Y QG + +V   LL + +  A   LV  +     RD+   T+  ++        ++ + 
Sbjct: 750 GYCQGLNRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEK 809

Query: 200 NPELHDFMQSAEVG-TIFALSW-LITWFGHVLSDFRHVVRLYDFFLACHPLMPIYFAAVI 257
            P LH   +  +V  T+   +W L+ +   V+SD   + +++D FL   P +   FA  +
Sbjct: 810 LPRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSDI--LFKIWDSFLYEGPKVIFRFALAL 867

Query: 258 VLYREQEVLDCDCDMASVHHL 278
             Y+E+E+L     M+   +L
Sbjct: 868 FKYKEEEILKLQDSMSIFKYL 888


>gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Homo
           sapiens]
          Length = 1266

 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 69/309 (22%), Positives = 114/309 (36%), Gaps = 28/309 (9%)

Query: 61  LTDEIRRKVWPKL---LNVNANDPPPISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEE 117
           + + +R ++W  L   +N  A  P        + M K Y     ++ R L R  P  P  
Sbjct: 516 IPESMRGELWLLLSGAINEKATHPGYYEDLVEKSMGK-YNLATEEIERDLHRSLPEHPAF 574

Query: 118 QREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLATSLVEKLSTHHLRDF 177
           Q E     L  ++     RNP + Y Q  + +    LL   E  A  L+  L    L D+
Sbjct: 575 QNEMGIAALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAFWLLVALCERMLPDY 634

Query: 178 MDPTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFALSWLITWFGHVLSDFRHVVR 237
            +  +            +     P+L+D MQ   V +  +LSW +T F  V+  F   V 
Sbjct: 635 YNTRVVGALVDQGVFEELARDYVPQLYDCMQDLGVISTISLSWFLTLFLSVM-PFESAVV 693

Query: 238 LYDFFLACHPLMPIYFAAVIVLYREQEVLDCDCD----------MASVHHLLSQIPQDLP 287
           + D F      +    A  ++     ++L+C  D          + SV +  S +P   P
Sbjct: 694 VVDCFFYEGIKVIFQLALAVLDANVDKLLNCKDDGEAMTVLGRYLDSVTNKDSTLP---P 750

Query: 288 YETLISRAGDLFVQFPPSELAREAAAQQQAERTAASTFKDFELASAQQRPDMVLRQRFRG 347
              L S   D    +P  ++           R   ++++ F    A     M  +QR + 
Sbjct: 751 IPHLHSLLSDDVEPYPEVDIF----------RLIRTSYEKFGTIRADLIEQMRFKQRLKV 800

Query: 348 LLRPEDRTK 356
           +   ED TK
Sbjct: 801 IQTLEDTTK 809


>gi|23503283 TBC1 domain family, member 21 [Homo sapiens]
          Length = 336

 Score = 40.8 bits (94), Expect = 0.002
 Identities = 52/243 (21%), Positives = 102/243 (41%), Gaps = 18/243 (7%)

Query: 60  LLTDEIRRKVWPKLLNVNANDPPPISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQR 119
           L  D +RRK +  L  +     P +   + R  ++    +  D+++   + P G     +
Sbjct: 84  LTVDSMRRKNYKALCQMYEKIQPLLENLH-RNFTETRNNIARDIQKIYDKDPLGNVLIDK 142

Query: 120 EGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLATSLVEKLSTHHLRDFMD 179
           + L++    I+LL    N Q  Y QG+H++++ F L+V     T  + +           
Sbjct: 143 KRLEK----ILLLSYVCNTQAEYQQGFHEMMMLFQLMVEHDHETFWLFQFFLQKTEHSCV 198

Query: 180 PTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFAL-SWLITWFGHVLSDFRHVVRL 238
             +   K+ L+ L  +I  ++P   + ++    G + +L  W    F      F  V RL
Sbjct: 199 INIGVAKN-LDMLSTLITFLDPVFAEHLKGKGAGAVQSLFPWFCFCFQRAFKSFDDVWRL 257

Query: 239 YDFFLA---CHPLMPIYFAAVIVLYRE---QEVLDCDCDMASVHHLLSQIPQDLPYETLI 292
           ++  L    C     +   +++ + RE   QE +  D  + + ++L+     DL  + LI
Sbjct: 258 WEVLLTGKPCRNFQVLVAYSMLQMVREQVLQESMGGDDILLACNNLI-----DLDADELI 312

Query: 293 SRA 295
           S A
Sbjct: 313 SAA 315


>gi|34147456 TBC domain-containing protein kinase-like [Homo
           sapiens]
          Length = 830

 Score = 40.0 bits (92), Expect = 0.004
 Identities = 42/185 (22%), Positives = 78/185 (42%), Gaps = 18/185 (9%)

Query: 137 NPQLHYYQGYHDIVVTFLLVV--GERLATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMP 194
           +P L Y+QG   +   FL +    E LA + +      +L +F    + +  H++   + 
Sbjct: 476 HPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFF---LKDNSHVIQEYLT 532

Query: 195 IIDQV----NPELHDFMQSAEVGTI---FALSWLITWFGHVLSDFRHVVRLYDFFLACHP 247
           +  Q+    +PEL + +   E+G I   +A+ W +T F HV      +  L+D  L  + 
Sbjct: 533 VFSQMIAFHDPELSNHLN--EIGFIPDLYAIPWFLTMFTHVF-PLHKIFHLWDTLLLGNS 589

Query: 248 LMPIYFAAVIVLYREQEVLDCDCDMASVHHLLSQIPQDLPYETLISRAGDLFVQFPPSEL 307
             P      I+      +L    +   +  L S +P ++  E  +  + +LF   P S  
Sbjct: 590 SFPFCIGVAILQQLRDRLLANGFNECIL--LFSDLP-EIDIERCVRESINLFCWTPKSAT 646

Query: 308 AREAA 312
            R+ A
Sbjct: 647 YRQHA 651


>gi|40068063 TBC1 domain family, member 22B [Homo sapiens]
          Length = 505

 Score = 39.3 bits (90), Expect = 0.006
 Identities = 50/224 (22%), Positives = 92/224 (41%), Gaps = 33/224 (14%)

Query: 87  KNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQLHYYQGY 146
           +N       Y+Q+ +D+ R+     P +P  Q+  +QE    I+ +   R+P   Y QG 
Sbjct: 256 RNEEHHQDTYRQIHIDIPRT----NPLIPLFQQPLVQEIFERILFIWAIRHPASGYVQGI 311

Query: 147 HDIVVTFLLV-----VGERLATSLVEKLSTHHLRDF-------MDPTMDNTKHILNYLMP 194
           +D+V  F +V     V E +    V  LS   LR         M   +D  +    +  P
Sbjct: 312 NDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDNYTFAQP 371

Query: 195 -----------IIDQVNPELHDFMQSAEVGTI-FALSWLITWFGHVLSDFRHVVRLYDFF 242
                      ++ +++ ++H+  +  EV  + FA  W+       L   R  +RL+D +
Sbjct: 372 GIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMREL-PLRCTIRLWDTY 430

Query: 243 LA---CHPLMPIYFAAVIVLYREQEVLDCDCDMASVHHLLSQIP 283
            +         +Y  A  ++   +E+LD + D   +  LL  +P
Sbjct: 431 QSEPEGFSHFHLYVCAAFLIKWRKEILD-EEDFQGLLMLLQNLP 473


>gi|45597177 TBC1 domain family, member 9B (with GRAM domain)
           isoform b [Homo sapiens]
          Length = 1233

 Score = 39.3 bits (90), Expect = 0.006
 Identities = 40/173 (23%), Positives = 66/173 (38%), Gaps = 1/173 (0%)

Query: 96  YQQVLLDVRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLL 155
           Y     ++ R L R  P  P  Q E     L  ++     RNP + Y Q  + +    LL
Sbjct: 546 YSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLL 605

Query: 156 VVGERLATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTI 215
              E  A  L+  L    L D+ +  +            +     P+L + MQ   V + 
Sbjct: 606 YGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISS 665

Query: 216 FALSWLITWFGHVLSDFRHVVRLYDFFLACHPLMPIYFAAVIVLYREQEVLDC 268
            +LSW +T F  V+  F   V + D F      + +  A  ++    +++L C
Sbjct: 666 ISLSWFLTLFLSVM-PFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGC 717


>gi|45597175 TBC1 domain family, member 9B (with GRAM domain)
           isoform a [Homo sapiens]
          Length = 1250

 Score = 39.3 bits (90), Expect = 0.006
 Identities = 40/173 (23%), Positives = 66/173 (38%), Gaps = 1/173 (0%)

Query: 96  YQQVLLDVRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLL 155
           Y     ++ R L R  P  P  Q E     L  ++     RNP + Y Q  + +    LL
Sbjct: 546 YSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLL 605

Query: 156 VVGERLATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTI 215
              E  A  L+  L    L D+ +  +            +     P+L + MQ   V + 
Sbjct: 606 YGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISS 665

Query: 216 FALSWLITWFGHVLSDFRHVVRLYDFFLACHPLMPIYFAAVIVLYREQEVLDC 268
            +LSW +T F  V+  F   V + D F      + +  A  ++    +++L C
Sbjct: 666 ISLSWFLTLFLSVM-PFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGC 717


>gi|38570101 TBC1 domain family, member 8B (with GRAM domain)
           isoform a [Homo sapiens]
          Length = 1120

 Score = 38.9 bits (89), Expect = 0.008
 Identities = 40/174 (22%), Positives = 66/174 (37%), Gaps = 1/174 (0%)

Query: 102 DVRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERL 161
           ++ R LRR  P  P  Q +     L  ++     RNP++ Y Q  + +    LL   E  
Sbjct: 531 EIERDLRRSLPEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEE 590

Query: 162 ATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFALSWL 221
           A  L+  +    L D+ +  +            +I    P+L + M      +  +LSW 
Sbjct: 591 AFWLLVAVCERMLPDYFNRRIIGALVDQAVFEELIRDHLPQLTEHMTDMTFFSSVSLSWF 650

Query: 222 ITWFGHVLSDFRHVVRLYDFFLACHPLMPIYFAAVIVLYREQEVLDCDCDMASV 275
           +T F  VL      V + D F        +     I+ Y   ++L C  D  +V
Sbjct: 651 LTLFISVL-PIESAVNVVDCFFYDGIKAILQLGLAILDYNLDKLLTCKDDAEAV 703


>gi|156231067 TBC1 domain family, member 8 [Homo sapiens]
          Length = 1140

 Score = 38.1 bits (87), Expect = 0.014
 Identities = 30/124 (24%), Positives = 49/124 (39%)

Query: 102 DVRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERL 161
           ++ R L R  P  P  Q E     L  ++     RNP++ Y Q  + +    LL   E  
Sbjct: 549 EIERDLHRSLPEHPAFQNETGIAALRRVLTAYAHRNPKIGYCQSMNILTSVLLLYTKEEE 608

Query: 162 ATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVNPELHDFMQSAEVGTIFALSWL 221
           A  L+  +    L D+ +  +   +   +    +I    PEL + M         +LSW 
Sbjct: 609 AFWLLVAVCERMLPDYFNHRVIGAQVDQSVFEELIKGHLPELAEHMNDLSALASVSLSWF 668

Query: 222 ITWF 225
           +T F
Sbjct: 669 LTLF 672


>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
          Length = 1406

 Score = 36.6 bits (83), Expect = 0.041
 Identities = 41/145 (28%), Positives = 63/145 (43%), Gaps = 17/145 (11%)

Query: 65  IRRKVWPKLLNVNA---NDPP--PISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQR 119
           IR  VW  LLN+      +P    I  +  ++ S+    + LDVR +LR        ++ 
Sbjct: 105 IRGPVWSVLLNIQEIKLKNPGRYQIMKERGKRSSEHIHHIDLDVRTTLRNHV--FFRDRY 162

Query: 120 EGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLA-TSLVEKLST--HHLRD 176
              Q EL  I+L   E NP++ Y +    I   FLL + E  A  +LV+ L++  H L  
Sbjct: 163 GAKQRELFYILLAYSEYNPEVGYCRDLSHITALFLLYLPEEDAFWALVQLLASERHSLPG 222

Query: 177 FMDPT-------MDNTKHILNYLMP 194
           F  P         D  +H++    P
Sbjct: 223 FHSPNGGTVQGLQDQQEHVVPKSQP 247


>gi|226693407 TBC1 domain family, member 3H [Homo sapiens]
          Length = 549

 Score = 36.2 bits (82), Expect = 0.054
 Identities = 41/146 (28%), Positives = 67/146 (45%), Gaps = 19/146 (13%)

Query: 65  IRRKVWPKLLNVNA---NDPP--PISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQR 119
           IR  +W  LLN+      +P    I  +  ++ S+  Q++  D+  +LR+    M    R
Sbjct: 106 IRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKH---MFFRDR 162

Query: 120 EGL-QEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLA-TSLVEKLST--HHLR 175
            G  Q EL+ I+L   E NP++ Y +    I   FLL + E  A  +LV+ L++  H L+
Sbjct: 163 YGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQ 222

Query: 176 DFMDPT-------MDNTKHILNYLMP 194
            F  P         D  +H++    P
Sbjct: 223 GFHSPNGGTVQGLQDQQEHVVATSQP 248


>gi|157502205 TBC1 domain family, member 3G [Homo sapiens]
          Length = 549

 Score = 36.2 bits (82), Expect = 0.054
 Identities = 41/146 (28%), Positives = 67/146 (45%), Gaps = 19/146 (13%)

Query: 65  IRRKVWPKLLNVNA---NDPP--PISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQR 119
           IR  +W  LLN+      +P    I  +  ++ S+  Q++  D+  +LR+    M    R
Sbjct: 106 IRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKH---MFFRDR 162

Query: 120 EGL-QEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLA-TSLVEKLST--HHLR 175
            G  Q EL+ I+L   E NP++ Y +    I   FLL + E  A  +LV+ L++  H L+
Sbjct: 163 YGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQ 222

Query: 176 DFMDPT-------MDNTKHILNYLMP 194
            F  P         D  +H++    P
Sbjct: 223 GFHSPNGGTVQGLQDQQEHVVATSQP 248


>gi|90577185 TBC1 domain family member 3C [Homo sapiens]
          Length = 549

 Score = 35.8 bits (81), Expect = 0.071
 Identities = 38/125 (30%), Positives = 61/125 (48%), Gaps = 12/125 (9%)

Query: 65  IRRKVWPKLLNVNA---NDPP--PISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQR 119
           IR  +W  LLN+      +P    I  +  ++ S+  Q++  D+  +LR+    M    R
Sbjct: 106 IRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKH---MFFRDR 162

Query: 120 EGL-QEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLA-TSLVEKLST--HHLR 175
            G  Q EL+ I+L   E NP++ Y +    I   FLL + E  A  +LV+ L++  H L+
Sbjct: 163 YGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQ 222

Query: 176 DFMDP 180
            F  P
Sbjct: 223 GFHSP 227


>gi|183583565 TBC1 domain family, member 3 [Homo sapiens]
          Length = 549

 Score = 35.0 bits (79), Expect = 0.12
 Identities = 41/146 (28%), Positives = 67/146 (45%), Gaps = 19/146 (13%)

Query: 65  IRRKVWPKLLNVNA---NDPP--PISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQR 119
           IR  +W  LLN+      +P    I  +  ++ S+  Q++  DV  +LR+    +    R
Sbjct: 106 IRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKH---IFFRDR 162

Query: 120 EGL-QEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLA-TSLVEKLST--HHLR 175
            G  Q EL+ I+L   E NP++ Y +    I   FLL + E  A  +LV+ L++  H L+
Sbjct: 163 YGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQ 222

Query: 176 DFMDPT-------MDNTKHILNYLMP 194
            F  P         D  +H++    P
Sbjct: 223 GFHSPNGGTVQGLQDQQEHVVATSQP 248


>gi|183583567 TBC1 domain family, member 3E [Homo sapiens]
          Length = 549

 Score = 35.0 bits (79), Expect = 0.12
 Identities = 41/146 (28%), Positives = 67/146 (45%), Gaps = 19/146 (13%)

Query: 65  IRRKVWPKLLNVNA---NDPP--PISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQR 119
           IR  +W  LLN+      +P    I  +  ++ S+  Q++  DV  +LR+    +    R
Sbjct: 106 IRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKH---IFFRDR 162

Query: 120 EGL-QEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLA-TSLVEKLST--HHLR 175
            G  Q EL+ I+L   E NP++ Y +    I   FLL + E  A  +LV+ L++  H L+
Sbjct: 163 YGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQ 222

Query: 176 DFMDPT-------MDNTKHILNYLMP 194
            F  P         D  +H++    P
Sbjct: 223 GFHSPNGGTVQGLQDQQEHVVATSQP 248


>gi|149999613 TBC1 domain family, member 3B [Homo sapiens]
          Length = 549

 Score = 35.0 bits (79), Expect = 0.12
 Identities = 38/125 (30%), Positives = 60/125 (48%), Gaps = 12/125 (9%)

Query: 65  IRRKVWPKLLNVNA---NDPP--PISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQR 119
           IR  +W  LLN+      +P    I  +  ++ S+  Q++  D+  +LR+    M    R
Sbjct: 106 IRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKH---MFFRDR 162

Query: 120 EGL-QEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLA-TSLVEKLST--HHLR 175
            G  Q EL+ I+L   E NP++ Y +    I   FLL   E  A  +LV+ L++  H L+
Sbjct: 163 YGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYFPEEDAFWALVQLLASERHSLQ 222

Query: 176 DFMDP 180
            F  P
Sbjct: 223 GFHSP 227


>gi|183583563 TBC1 domain family, member 3D [Homo sapiens]
          Length = 549

 Score = 35.0 bits (79), Expect = 0.12
 Identities = 41/146 (28%), Positives = 67/146 (45%), Gaps = 19/146 (13%)

Query: 65  IRRKVWPKLLNVNA---NDPP--PISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQR 119
           IR  +W  LLN+      +P    I  +  ++ S+  Q++  DV  +LR+    +    R
Sbjct: 106 IRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKH---IFFRDR 162

Query: 120 EGL-QEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLA-TSLVEKLST--HHLR 175
            G  Q EL+ I+L   E NP++ Y +    I   FLL + E  A  +LV+ L++  H L+
Sbjct: 163 YGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQ 222

Query: 176 DFMDPT-------MDNTKHILNYLMP 194
            F  P         D  +H++    P
Sbjct: 223 GFHSPNGGTVQGLQDQQEHVVATSQP 248


>gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo
           sapiens]
          Length = 486

 Score = 34.7 bits (78), Expect = 0.16
 Identities = 29/108 (26%), Positives = 48/108 (44%), Gaps = 11/108 (10%)

Query: 21  EKADFNAKRKKKVAEIHQALNSDPTDVAALRRMAISEGGLLTDEIRRKVWPKLLNVNAND 80
           EKA   A+R+++   + +     P  V A+   A+     L  +I  + WP +       
Sbjct: 256 EKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAP--LPKKISSEAWPPV------G 307

Query: 81  PPPISGKNLRQMSKDYQQVLLDVRRSL---RRFPPGMPEEQREGLQEE 125
            PP S     + S+++   LL +R++L      PP +P    EGLQ E
Sbjct: 308 TPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVE 355


>gi|14149985 TBC1 domain family, member 3F [Homo sapiens]
          Length = 549

 Score = 34.3 bits (77), Expect = 0.21
 Identities = 41/146 (28%), Positives = 67/146 (45%), Gaps = 19/146 (13%)

Query: 65  IRRKVWPKLLN---VNANDPP--PISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQR 119
           IR  +W  LLN   +   +P    I  +  ++ S+  Q++  DV  +LR+    +    R
Sbjct: 106 IRGPMWSVLLNTEEMKLKNPGRYQIMKEKGKKSSEHIQRIDRDVSGTLRKH---IFFRDR 162

Query: 120 EGL-QEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLA-TSLVEKLST--HHLR 175
            G  Q EL+ I+L   E NP++ Y +    I   FLL + E  A  +LV+ L++  H L+
Sbjct: 163 YGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQ 222

Query: 176 DFMDPT-------MDNTKHILNYLMP 194
            F  P         D  +H++    P
Sbjct: 223 GFHSPNGGTVQGLQDQQEHVVATSQP 248


>gi|239755792 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 257

 Score = 33.9 bits (76), Expect = 0.27
 Identities = 35/122 (28%), Positives = 52/122 (42%), Gaps = 9/122 (7%)

Query: 57  EGGLLTDEIRRKVWPKLLNVNANDPPPIS----GKNLRQMSKDYQQVLLDVRRSLRRFPP 112
           EGGLL  E+ RK  P     + +   P      G++L Q  +   QVL      +R  P 
Sbjct: 28  EGGLLPPELGRKKTPGDFLAHRHGRVPHQEARLGQHLAQALEQVLQVLQVASPGVRTIPG 87

Query: 113 GMPEEQREGLQEELIDIILLILERNPQLHYYQGYH--DIVVTFLLVVGERLATSLVEKLS 170
            +PE    G+ ++ +  +L  L+         G H  + V T+ +VVG  LA   V K  
Sbjct: 88  DVPE---AGIHDDQVGGVLARLQLFQDGLEVIGVHAGEEVKTYQMVVGAELADLTVVKAV 144

Query: 171 TH 172
            H
Sbjct: 145 VH 146


>gi|239750294 PREDICTED: hypothetical protein XP_002347346 [Homo
           sapiens]
          Length = 257

 Score = 33.9 bits (76), Expect = 0.27
 Identities = 35/122 (28%), Positives = 52/122 (42%), Gaps = 9/122 (7%)

Query: 57  EGGLLTDEIRRKVWPKLLNVNANDPPPIS----GKNLRQMSKDYQQVLLDVRRSLRRFPP 112
           EGGLL  E+ RK  P     + +   P      G++L Q  +   QVL      +R  P 
Sbjct: 28  EGGLLPPELGRKKTPGDFLAHRHGRVPHQEARLGQHLAQALEQVLQVLQVASPGVRTIPG 87

Query: 113 GMPEEQREGLQEELIDIILLILERNPQLHYYQGYH--DIVVTFLLVVGERLATSLVEKLS 170
            +PE    G+ ++ +  +L  L+         G H  + V T+ +VVG  LA   V K  
Sbjct: 88  DVPE---AGIHDDQVGGVLARLQLFQDGLEVIGVHAGEEVKTYQMVVGAELADLTVVKAV 144

Query: 171 TH 172
            H
Sbjct: 145 VH 146


>gi|239744603 PREDICTED: hypothetical protein XP_002343238 [Homo
           sapiens]
          Length = 257

 Score = 33.9 bits (76), Expect = 0.27
 Identities = 35/122 (28%), Positives = 52/122 (42%), Gaps = 9/122 (7%)

Query: 57  EGGLLTDEIRRKVWPKLLNVNANDPPPIS----GKNLRQMSKDYQQVLLDVRRSLRRFPP 112
           EGGLL  E+ RK  P     + +   P      G++L Q  +   QVL      +R  P 
Sbjct: 28  EGGLLPPELGRKKTPGDFLAHRHGRVPHQEARLGQHLAQALEQVLQVLQVASPGVRTIPG 87

Query: 113 GMPEEQREGLQEELIDIILLILERNPQLHYYQGYH--DIVVTFLLVVGERLATSLVEKLS 170
            +PE    G+ ++ +  +L  L+         G H  + V T+ +VVG  LA   V K  
Sbjct: 88  DVPE---AGIHDDQVGGVLARLQLFQDGLEVIGVHAGEEVKTYQMVVGAELADLTVVKAV 144

Query: 171 TH 172
            H
Sbjct: 145 VH 146


>gi|197304777 TBC1 domain family, member 5 isoform a [Homo sapiens]
          Length = 817

 Score = 33.5 bits (75), Expect = 0.35
 Identities = 15/55 (27%), Positives = 30/55 (54%)

Query: 103 VRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVV 157
           + + ++R  P M   Q+E +++ L D++      N QL Y QG H+++   + V+
Sbjct: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVL 217


>gi|197304775 TBC1 domain family, member 5 isoform b [Homo sapiens]
          Length = 795

 Score = 33.5 bits (75), Expect = 0.35
 Identities = 15/55 (27%), Positives = 30/55 (54%)

Query: 103 VRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVV 157
           + + ++R  P M   Q+E +++ L D++      N QL Y QG H+++   + V+
Sbjct: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVL 217


>gi|7661998 TBC1 domain family, member 5 isoform b [Homo sapiens]
          Length = 795

 Score = 33.5 bits (75), Expect = 0.35
 Identities = 15/55 (27%), Positives = 30/55 (54%)

Query: 103 VRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVV 157
           + + ++R  P M   Q+E +++ L D++      N QL Y QG H+++   + V+
Sbjct: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVL 217


>gi|148235002 TBC1 domain family, member 26 [Homo sapiens]
          Length = 250

 Score = 33.1 bits (74), Expect = 0.46
 Identities = 31/138 (22%), Positives = 66/138 (47%), Gaps = 9/138 (6%)

Query: 28  KRKKKVAEIHQALNSDPTDVAALRRMAISEGGLLTDEIRRKVWPKLLNVNA-NDPPPISG 86
           +++ K     Q + +D T   + ++++     ++   +R + W  LL+++      P   
Sbjct: 69  RKESKRTNKWQKMLADWTKYRSTKKLSQRVYKVIPLAVRGRAWSLLLDIDRIKSQNPGKY 128

Query: 87  KNLRQMSKDYQQVL----LDVRRSLRRFPPGMPEEQREGL-QEELIDIILLILERNPQLH 141
           K +++  K   +++    LDV  +L++    M   QR G+ Q+EL DI++     NP++ 
Sbjct: 129 KVMKEKGKRSSRIIHCIQLDVSHTLQKH---MMFIQRFGVKQQELCDILVAYSAYNPEVG 185

Query: 142 YYQGYHDIVVTFLLVVGE 159
           Y++    I    LL + E
Sbjct: 186 YHRDLSRITAILLLCLPE 203


>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
          Length = 2325

 Score = 30.8 bits (68), Expect = 2.3
 Identities = 21/95 (22%), Positives = 42/95 (44%), Gaps = 16/95 (16%)

Query: 22  KADFNAKRKKKVAEIHQALNSDPTDVAALRR----------------MAISEGGLLTDEI 65
           KA F+ +++++ +E+H  L     D   L++                +   E     DE+
Sbjct: 757 KAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDEL 816

Query: 66  RRKVWPKLLNVNANDPPPISGKNLRQMSKDYQQVL 100
           RRK+      +N + P  + GK+L  + K + ++L
Sbjct: 817 RRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEIL 851


>gi|14150045 calcium/calmodulin-dependent protein kinase 1 alpha
           isoform a [Homo sapiens]
          Length = 505

 Score = 30.4 bits (67), Expect = 3.0
 Identities = 15/40 (37%), Positives = 25/40 (62%), Gaps = 2/40 (5%)

Query: 100 LLDVRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQ 139
           +L + R ++  P   PEE    + EEL D+IL +L++NP+
Sbjct: 358 ILALHRKIKNEPVVFPEEPE--ISEELKDLILKMLDKNPE 395


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.137    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,106,624
Number of Sequences: 37866
Number of extensions: 649921
Number of successful extensions: 1685
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 1674
Number of HSP's gapped (non-prelim): 42
length of query: 403
length of database: 18,247,518
effective HSP length: 105
effective length of query: 298
effective length of database: 14,271,588
effective search space: 4252933224
effective search space used: 4252933224
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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