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Search of human proteins with 213688413
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|213688413 coiled-coil domain containing 66 isoform 2 [Homo
sapiens]
(914 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|213688415 coiled-coil domain containing 66 isoform 1 [Homo sa... 1829 0.0
gi|213688413 coiled-coil domain containing 66 isoform 2 [Homo sa... 1829 0.0
gi|148746195 trichohyalin [Homo sapiens] 79 1e-14
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 68 3e-11
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 68 4e-11
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 67 6e-11
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 67 1e-10
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 66 2e-10
gi|116174778 centrosome spindle pole associated protein 1 isofor... 65 2e-10
gi|116174789 centrosome spindle pole associated protein 1 isofor... 65 2e-10
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 65 3e-10
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 65 3e-10
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 65 3e-10
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 65 3e-10
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 64 6e-10
gi|221219020 NYD-SP11 protein [Homo sapiens] 64 8e-10
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 64 8e-10
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 63 1e-09
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 63 1e-09
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 63 1e-09
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 63 1e-09
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 63 1e-09
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 63 1e-09
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 63 1e-09
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 63 1e-09
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 63 1e-09
gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens] 62 2e-09
gi|4506467 radixin [Homo sapiens] 62 3e-09
gi|41152097 DNA segment on chromosome X and Y (unique) 155 expre... 61 4e-09
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 61 5e-09
>gi|213688415 coiled-coil domain containing 66 isoform 1 [Homo
sapiens]
Length = 948
Score = 1829 bits (4737), Expect = 0.0
Identities = 914/914 (100%), Positives = 914/914 (100%)
Query: 1 MGNKAKIAKCPLRTKTGHILKSTQDTCIGSEKLLQKKPVGSETSQAKGEKNGMTFSSTKD 60
MGNKAKIAKCPLRTKTGHILKSTQDTCIGSEKLLQKKPVGSETSQAKGEKNGMTFSSTKD
Sbjct: 35 MGNKAKIAKCPLRTKTGHILKSTQDTCIGSEKLLQKKPVGSETSQAKGEKNGMTFSSTKD 94
Query: 61 LCKQCIDKDCLHIQKEISPATPNMQKTRNTVNTSLVGKQKPHKKHITAENMKSSLVCLTQ 120
LCKQCIDKDCLHIQKEISPATPNMQKTRNTVNTSLVGKQKPHKKHITAENMKSSLVCLTQ
Sbjct: 95 LCKQCIDKDCLHIQKEISPATPNMQKTRNTVNTSLVGKQKPHKKHITAENMKSSLVCLTQ 154
Query: 121 DQLQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTEMVSSVP 180
DQLQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTEMVSSVP
Sbjct: 155 DQLQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTEMVSSVP 214
Query: 181 AENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQ 240
AENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQ
Sbjct: 215 AENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQ 274
Query: 241 VALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIE 300
VALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIE
Sbjct: 275 VALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIE 334
Query: 301 ELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCV 360
ELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCV
Sbjct: 335 ELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCV 394
Query: 361 SPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQI 420
SPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQI
Sbjct: 395 SPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQI 454
Query: 421 EERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEED 480
EERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEED
Sbjct: 455 EERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEED 514
Query: 481 ILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTI 540
ILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTI
Sbjct: 515 ILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTI 574
Query: 541 QMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCGSLME 600
QMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCGSLME
Sbjct: 575 QMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCGSLME 634
Query: 601 RDITNCSSPEISAELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQTKHM 660
RDITNCSSPEISAELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQTKHM
Sbjct: 635 RDITNCSSPEISAELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQTKHM 694
Query: 661 KKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEKKVRRQMELLHLVEKNNPGHLSQNR 720
KKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEKKVRRQMELLHLVEKNNPGHLSQNR
Sbjct: 695 KKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEKKVRRQMELLHLVEKNNPGHLSQNR 754
Query: 721 GISPEIFHSSHQETESKLRWHLVKKEEEPLNIHSFSKERSPSSPVPVVKNRTQQTQNTLH 780
GISPEIFHSSHQETESKLRWHLVKKEEEPLNIHSFSKERSPSSPVPVVKNRTQQTQNTLH
Sbjct: 755 GISPEIFHSSHQETESKLRWHLVKKEEEPLNIHSFSKERSPSSPVPVVKNRTQQTQNTLH 814
Query: 781 LPLKNSSYERENLISGSNQTELSSGISESSHFIPYVRTNEIYYLDPDAPLSGPSTQDPQY 840
LPLKNSSYERENLISGSNQTELSSGISESSHFIPYVRTNEIYYLDPDAPLSGPSTQDPQY
Sbjct: 815 LPLKNSSYERENLISGSNQTELSSGISESSHFIPYVRTNEIYYLDPDAPLSGPSTQDPQY 874
Query: 841 QNSQDCGQKRQLFDSDCVRDPLLNPNMVKNRDRQQAILKGLSELRQGLLQKQKELESSLL 900
QNSQDCGQKRQLFDSDCVRDPLLNPNMVKNRDRQQAILKGLSELRQGLLQKQKELESSLL
Sbjct: 875 QNSQDCGQKRQLFDSDCVRDPLLNPNMVKNRDRQQAILKGLSELRQGLLQKQKELESSLL 934
Query: 901 PLAENQEESFGSSF 914
PLAENQEESFGSSF
Sbjct: 935 PLAENQEESFGSSF 948
>gi|213688413 coiled-coil domain containing 66 isoform 2 [Homo
sapiens]
Length = 914
Score = 1829 bits (4737), Expect = 0.0
Identities = 914/914 (100%), Positives = 914/914 (100%)
Query: 1 MGNKAKIAKCPLRTKTGHILKSTQDTCIGSEKLLQKKPVGSETSQAKGEKNGMTFSSTKD 60
MGNKAKIAKCPLRTKTGHILKSTQDTCIGSEKLLQKKPVGSETSQAKGEKNGMTFSSTKD
Sbjct: 1 MGNKAKIAKCPLRTKTGHILKSTQDTCIGSEKLLQKKPVGSETSQAKGEKNGMTFSSTKD 60
Query: 61 LCKQCIDKDCLHIQKEISPATPNMQKTRNTVNTSLVGKQKPHKKHITAENMKSSLVCLTQ 120
LCKQCIDKDCLHIQKEISPATPNMQKTRNTVNTSLVGKQKPHKKHITAENMKSSLVCLTQ
Sbjct: 61 LCKQCIDKDCLHIQKEISPATPNMQKTRNTVNTSLVGKQKPHKKHITAENMKSSLVCLTQ 120
Query: 121 DQLQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTEMVSSVP 180
DQLQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTEMVSSVP
Sbjct: 121 DQLQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTEMVSSVP 180
Query: 181 AENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQ 240
AENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQ
Sbjct: 181 AENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQ 240
Query: 241 VALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIE 300
VALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIE
Sbjct: 241 VALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIE 300
Query: 301 ELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCV 360
ELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCV
Sbjct: 301 ELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCV 360
Query: 361 SPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQI 420
SPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQI
Sbjct: 361 SPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQI 420
Query: 421 EERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEED 480
EERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEED
Sbjct: 421 EERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEED 480
Query: 481 ILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTI 540
ILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTI
Sbjct: 481 ILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTI 540
Query: 541 QMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCGSLME 600
QMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCGSLME
Sbjct: 541 QMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCGSLME 600
Query: 601 RDITNCSSPEISAELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQTKHM 660
RDITNCSSPEISAELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQTKHM
Sbjct: 601 RDITNCSSPEISAELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQTKHM 660
Query: 661 KKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEKKVRRQMELLHLVEKNNPGHLSQNR 720
KKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEKKVRRQMELLHLVEKNNPGHLSQNR
Sbjct: 661 KKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEKKVRRQMELLHLVEKNNPGHLSQNR 720
Query: 721 GISPEIFHSSHQETESKLRWHLVKKEEEPLNIHSFSKERSPSSPVPVVKNRTQQTQNTLH 780
GISPEIFHSSHQETESKLRWHLVKKEEEPLNIHSFSKERSPSSPVPVVKNRTQQTQNTLH
Sbjct: 721 GISPEIFHSSHQETESKLRWHLVKKEEEPLNIHSFSKERSPSSPVPVVKNRTQQTQNTLH 780
Query: 781 LPLKNSSYERENLISGSNQTELSSGISESSHFIPYVRTNEIYYLDPDAPLSGPSTQDPQY 840
LPLKNSSYERENLISGSNQTELSSGISESSHFIPYVRTNEIYYLDPDAPLSGPSTQDPQY
Sbjct: 781 LPLKNSSYERENLISGSNQTELSSGISESSHFIPYVRTNEIYYLDPDAPLSGPSTQDPQY 840
Query: 841 QNSQDCGQKRQLFDSDCVRDPLLNPNMVKNRDRQQAILKGLSELRQGLLQKQKELESSLL 900
QNSQDCGQKRQLFDSDCVRDPLLNPNMVKNRDRQQAILKGLSELRQGLLQKQKELESSLL
Sbjct: 841 QNSQDCGQKRQLFDSDCVRDPLLNPNMVKNRDRQQAILKGLSELRQGLLQKQKELESSLL 900
Query: 901 PLAENQEESFGSSF 914
PLAENQEESFGSSF
Sbjct: 901 PLAENQEESFGSSF 914
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 79.3 bits (194), Expect = 1e-14
Identities = 85/380 (22%), Positives = 168/380 (44%), Gaps = 47/380 (12%)
Query: 182 ENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQV 241
E + L E QE + EQ+ + W+ + ER+ R +L AK A + EQ
Sbjct: 851 EEEDGLQEDQERRRSQEQRRDQKWRWQLEE------ERKRRRHTLYAKPALQEQLRKEQQ 904
Query: 242 ALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWI-- 299
L+++E+E+ + + ++ E ++ E+ Q L Q E +L E +QE +R++
Sbjct: 905 LLQEEEEELQREEREKRRRQEQERQYREEEQ-LQQEEEQLLREEREKRRRQERERQYRKD 963
Query: 300 ------------EELNKQIEDDRQRKI---------EEKIIYSKGEEHDR--WAMHFDSL 336
EE K+ +R++K EE+++ + E+ R W +
Sbjct: 964 KKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK 1023
Query: 337 KSYPGSQSQLFSQSTHKQ--PEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPI 394
+ QL + K+ E + +EL G + E + + +
Sbjct: 1024 DELQQEEEQLLREEREKRRLQERERQYREEEELQQEEE---QLLGEERETRRRQELERQY 1080
Query: 395 KDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQ 454
+ ++ LR + E + R ++ + ++ + + EKRR+++LE +
Sbjct: 1081 RKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQY 1140
Query: 455 RKKEE--QEEELRLAQE-----REEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQ---R 504
R++EE QEEE L +E R+E+++QY E+ Q+++E+++ + + Q + R
Sbjct: 1141 REEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYR 1200
Query: 505 AQELAQRLKQEQRIRELAQK 524
+E QR K++QR R+ Q+
Sbjct: 1201 EEEELQRQKRKQRYRDEDQR 1220
Score = 68.9 bits (167), Expect = 2e-11
Identities = 66/349 (18%), Positives = 164/349 (46%), Gaps = 34/349 (9%)
Query: 182 ENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQV 241
E + +L E +ET ++ E +E +++ + E+ + ++ + ++ E+
Sbjct: 1059 EEEQLLGEERETRRRQE----LERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEE 1114
Query: 242 ALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEE 301
L+++E+++ + + ++ E ++ E+ ++ Q E +L E P +QEL+R++ EE
Sbjct: 1115 ELQQEEEQLLREEREKRRRQELERQYREEEEV-QQEEEQLLREEPEKRRRQELERQYREE 1173
Query: 302 LNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVS 361
Q E+++ + E++ + +E +R + L+ + Q + + +
Sbjct: 1174 EELQQEEEQLLREEQE---KRRQERERQYREEEELQRQ--KRKQRYRDEDQRSDLKWQWE 1228
Query: 362 PDTQE-LADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQI 420
P+ + + D C Q E+ + + + + LL Q
Sbjct: 1229 PEKENAVRDNKVYCKGRENEQFRQLEDSQL------------RDRQSQQDLQHLLGEQQE 1276
Query: 421 EERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQY--- 477
+R++ R++ + + + E+ R++Q E ++R ++ QEE+ L +EREE +++
Sbjct: 1277 RDREQERRRWQQRDRHFPEE-EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETD 1335
Query: 478 -----EEDILKQKQKEEIMTLKTNELFQTMQ-RAQELAQR-LKQEQRIR 519
EE +L++++++ + + + F+ + R QE ++ L++EQR+R
Sbjct: 1336 RKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLR 1384
Score = 67.0 bits (162), Expect = 8e-11
Identities = 122/604 (20%), Positives = 234/604 (38%), Gaps = 107/604 (17%)
Query: 171 KKTEMVSSVPAENKSVLNEHQETSKQC--EQKIAIENEWKPADIFSTLGERECDRSSLEA 228
+K++ + E + QET ++ E+++ E E +P L +E DR E
Sbjct: 1312 RKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQP------LRRQERDRKFREE 1365
Query: 229 K---KAQWRKELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEH 285
+ + Q RK L+E+ L+++E+E + K E E+ Q L Q R+ E
Sbjct: 1366 ELRHQEQGRKFLEEEQRLRRQERERK------FLKEEQQLRCQEREQQLRQDRDRKFREE 1419
Query: 286 PFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQ 345
+QE RK+ EE + +R+RK E+ + E H ++ L+
Sbjct: 1420 EQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQERE----- 1474
Query: 346 LFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKT 405
Q H+Q + Q+L +E K + + + +
Sbjct: 1475 --EQQLHRQERDRKFLEEEQQLR-----------------RQERDRKFREQELRSQEPER 1515
Query: 406 NFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRK----KQLEEEQRKKEEQE 461
FL L R +R++K L+ ++ + Q ++R+ ++ EE++ ++E+E
Sbjct: 1516 KFLEEEQQL-------HRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQERE 1568
Query: 462 EELRLAQEREEMQKQYEEDILKQKQKEEIM----TLKTNE----LFQTMQRAQELAQRLK 513
E+ QER+ + E+ + +Q+Q+ + M L+ E L Q R ++L
Sbjct: 1569 EQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLL 1628
Query: 514 QEQRIRELAQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSK 573
QE+ ++L ++ D L + + + E RHD D + + +
Sbjct: 1629 QEREEQQLHRQERDRKFLEEEPQLRRQERE------QQLRHDRDRKFREEEQLLQEGEEQ 1682
Query: 574 KDTGVQTDDLNIGIFTNAESHCGSLMERDITNCSSPEISAELIGQFSTKKNKQELTQDKG 633
+ + R + E +L Q +K QE Q +
Sbjct: 1683 Q------------------------LRRQERDRKFREEEQQLRRQERERKFLQEEQQLRR 1718
Query: 634 ASLEK-----ENNRCNDQCNQFTRIEKQTKHMKKYPKRPDWNINKPPKRYIPASEKYPKQ 688
LE+ E R + Q R E+ K +++ RP+ + ++ + +Q
Sbjct: 1719 QELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQ 1778
Query: 689 LQKQREEKKVRRQMELLHLVEKNNPGHLSQNRGISPEIFHSSHQETESKLRWHLVKKEEE 748
L+++REE+++R Q E+ + + + P Q+ + K RW EEE
Sbjct: 1779 LRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRP-------QQRDGKYRW-----EEE 1826
Query: 749 PLNI 752
L +
Sbjct: 1827 QLQL 1830
Score = 66.6 bits (161), Expect = 1e-10
Identities = 111/581 (19%), Positives = 232/581 (39%), Gaps = 57/581 (9%)
Query: 188 NEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQVALKKKE 247
+E QE +Q +++ E W+ + ER + L++ K +E ++ L+++E
Sbjct: 155 SEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE 214
Query: 248 ----KEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEELN 303
+ + ++ D++ E+ + + RETVL + ++E QR+ EL
Sbjct: 215 LLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ--REL- 271
Query: 304 KQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSPD 363
Q E+++ RK+E + + + +E ++ + Q + + ++ E
Sbjct: 272 -QEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQ 330
Query: 364 TQELAD--VSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIE 421
+E + + Q+ +EE + ++ LR L Q+
Sbjct: 331 QEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLR 390
Query: 422 -ERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEED 480
E+ RR++QL ++ + + ++ RR++QL EQ+ + EQEEE + ++ +++ E
Sbjct: 391 REQQLRREQQLRREQQLRRE-QQLRREQQLRREQQLRREQEEE----RHEQKHEQERREQ 445
Query: 481 ILKQKQKEEIMTLK---TNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIKNLGV 537
LK++Q+E LK E + +R Q+L + ++E+R R L + +
Sbjct: 446 RLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERRE------- 498
Query: 538 DTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCGS 597
Q E + + + E K + + Q + E
Sbjct: 499 ---QQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQ-------LRREQEERREQ 548
Query: 598 LMERDITNCSSPEISAELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQT 657
L++R+ E E + K +QE +D+ E+E + + Q R+E++
Sbjct: 549 LLKRE------EEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRL 602
Query: 658 KHMKKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEKKVRRQMELLHLVEKNNPGHLS 717
K + + + KR P E+ +Q + EE++ RRQ +L ++ L
Sbjct: 603 KREEVERLEQEERREQRLKREEPEEER--RQQLLKSEEQEERRQQQLRREQQERREQRLK 660
Query: 718 QNRGISPEIFHSSHQETESKLRWHLVKKEEEPLNIHSFSKE 758
+ +E E +L L ++ EE ++E
Sbjct: 661 R-------------EEEEERLEQRLKREHEEERREQELAEE 688
Score = 61.6 bits (148), Expect = 3e-09
Identities = 70/319 (21%), Positives = 147/319 (46%), Gaps = 39/319 (12%)
Query: 229 KKAQWRKELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFS 288
++ Q R+E + ++A +++ E E+ + D+ +W + Q + E E
Sbjct: 136 RRRQKRQEQERELAEGEEQSEKQERLEQR-DRQRRDEELWRQRQEWQEREERRAEEEQLQ 194
Query: 289 AVK----------QELQRKWIEELNKQ-IEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLK 337
+ K ++L+R+ + EL ++ E+ +Q++ E + + EE W L+
Sbjct: 195 SCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLR 254
Query: 338 SYPGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDV 397
+ +L + +Q E + + ++L + + E EEE + ++
Sbjct: 255 K---EEEKLQEEEPQRQRE---LQEEEEQLRKLER-----QELRRERQEEEQQQQRLRRE 303
Query: 398 VMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKR----RKKQLEE- 452
K+ R + E+++RR Q++ ++ + + EE+R R++Q EE
Sbjct: 304 QQLRRKQEEERREQ----QEERREQQERREQQEERREQQLRREQEERREQQLRREQEEER 359
Query: 453 -EQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQEL--A 509
EQ+ + EQEEE R Q R E Q + E+ + +++Q L+ Q ++R Q+L
Sbjct: 360 REQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRRE---QQLRREQQLRRE 416
Query: 510 QRLKQEQRI-RELAQKGHD 527
Q+L++EQ++ RE ++ H+
Sbjct: 417 QQLRREQQLRREQEEERHE 435
Score = 60.5 bits (145), Expect = 7e-09
Identities = 78/394 (19%), Positives = 169/394 (42%), Gaps = 41/394 (10%)
Query: 157 ISNQPKDENIMGLFKKTEMVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTL 216
+S Q +D F++ E + L E Q+ ++ +K E + L
Sbjct: 1423 LSRQERDRK----FREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQL 1478
Query: 217 GERECDRSSLEAKKAQWRKELD-----EQVALKKKEKEVSEKWNDPWKKSESDKIIWEKH 271
+E DR LE ++ R+E D +++ ++ E++ E+ ++ K + E+
Sbjct: 1479 HRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQ 1538
Query: 272 QILDQSR---ETVLLEHPFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDR 328
Q+ Q R + F +Q Q + ++L++Q E DR+ ++EE+ + + +E +R
Sbjct: 1539 QLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQ-ERDRKFRLEEQKV--RRQEQER 1595
Query: 329 WAMHFDSLKSYPGSQSQLFSQSTHK------------QPEYFCVSPDTQELADVSSVCTP 376
M + Q QL + K + + D + L + +
Sbjct: 1596 KFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQ 1655
Query: 377 TTGSQVEPS------EEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQ 430
Q+ EEE + + ++ + ++ R L + E + + ++Q
Sbjct: 1656 EREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQ 1715
Query: 431 LEHQKAITAQVEEKRRKKQLEEEQRKKEEQE----EELRLAQEREEMQKQYEEDILKQKQ 486
L Q+ EE++ +++ E+EQ +++E+ EE +L EREE Q + +E K ++
Sbjct: 1716 LRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFRE 1775
Query: 487 KEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRE 520
+E++ E + R+QE ++ ++E+++R+
Sbjct: 1776 EEQL----RQEREEQQLRSQESDRKFREEEQLRQ 1805
Score = 59.7 bits (143), Expect = 1e-08
Identities = 114/616 (18%), Positives = 237/616 (38%), Gaps = 100/616 (16%)
Query: 192 ETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKE------------LDE 239
E +Q EQ+ E E K ERE + LE ++ R+E ++
Sbjct: 801 EERQQREQRFLPEEEEKEQRRRQRR-EREKELQFLEEEEQLQRRERAQQLQEEEDGLQED 859
Query: 240 QVALKKKEKEVSEKWNDPWKKSESDK--------------IIWEKHQILDQSRETVLLEH 285
Q + +E+ +KW W+ E K + ++ Q+L + E + E
Sbjct: 860 QERRRSQEQRRDQKWR--WQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREE 917
Query: 286 PFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQ 345
+QE +R++ EE +Q++ + ++ + E+ + +E +R + K + Q
Sbjct: 918 REKRRRQEQERQYREE--EQLQQEEEQLLREEREKRRRQERER---QYRKDKKLQQKEEQ 972
Query: 346 LFSQSTHK----------------QPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEH 389
L + K Q E + + +E EEE
Sbjct: 973 LLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQ 1032
Query: 390 IAKPIKDVVMANSKKTNFLRSMTALLDPAQI--EERDRRRQKQLEHQ-----------KA 436
+ + ++ ++ + + Q+ EER+ RR+++LE Q +
Sbjct: 1033 LLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQ 1092
Query: 437 ITAQVEEKRRKKQLEEEQRKKEE--QEEELRLAQERE-----EMQKQYEEDILKQKQKEE 489
+ + EKRR+++ E + R++EE QEEE L +ERE E+++QY E+ Q+++E+
Sbjct: 1093 LLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQ 1152
Query: 490 IMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTIQMEYNASNI 549
++ + + +R QEL ++ ++E+ +++ + +L++ + E
Sbjct: 1153 LLREEPEK-----RRRQELERQYREEEELQQ------EEEQLLRE------EQEKRRQER 1195
Query: 550 SNSRHDSDEIS-GKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCGSLMERDITNCSS 608
+ +E+ K + D Q + + + +C
Sbjct: 1196 ERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLE- 1254
Query: 609 PEISAELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQTKHMKKYPKRPD 668
++L + S + + L + + E+E R + F E+ + +K KR D
Sbjct: 1255 ---DSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRD 1311
Query: 669 WNINKPPKRYIPASEKYPKQLQKQREEKKVRRQMELLHLVEKNNPGHLSQNRGISPEIFH 728
K + E+ ++ ++Q ++K R + +LL E+ ++R E
Sbjct: 1312 ---RKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELR 1368
Query: 729 SSHQ-----ETESKLR 739
Q E E +LR
Sbjct: 1369 HQEQGRKFLEEEQRLR 1384
Score = 57.4 bits (137), Expect = 6e-08
Identities = 86/379 (22%), Positives = 165/379 (43%), Gaps = 47/379 (12%)
Query: 191 QETSKQCEQKIAIENEWKPADIFSTLGERECDRS-SLEAKKA----QWRKELDEQVALKK 245
Q+ + ++K E + + L +E DR LE +K Q RK ++++ L++
Sbjct: 1547 QQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRR 1606
Query: 246 KEKEVSEKWNDPWKKSESDKIIWEKH--QILDQSRETVLLEHPFSAVKQELQRKWIEELN 303
+E + + K E ++++ E+ Q+ Q R+ LE + +L+R +E
Sbjct: 1607 QEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEE-----EPQLRR---QERE 1658
Query: 304 KQIEDDRQRKI-EEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHK---QPEYFC 359
+Q+ DR RK EE+ + +GEE D + + + QL Q + Q E
Sbjct: 1659 QQLRHDRDRKFREEEQLLQEGEEQQLRRQERD--RKFREEEQQLRRQERERKFLQEEQQL 1716
Query: 360 VSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQ 419
+ + T Q + +E K +++ + ++ LR +
Sbjct: 1717 RRQELERKFREEEQLRQET-EQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFRE 1775
Query: 420 IEE-RDRRRQKQLEHQKAITA-----QVEEKRRKKQLEEEQRK-----KEEQ----EEEL 464
E+ R R ++QL Q++ Q+ ++R ++QL +QR +EEQ E+E
Sbjct: 1776 EEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQ 1835
Query: 465 RLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQ------RAQELAQRLKQEQRI 518
RL QER+ + E+ ++K + E L E + Q R + + ++ K+EQR
Sbjct: 1836 RLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRH 1895
Query: 519 REL----AQKGHDTSRLIK 533
R++ +Q+G RL++
Sbjct: 1896 RQVGEIKSQEGKGHGRLLE 1914
Score = 54.7 bits (130), Expect = 4e-07
Identities = 66/326 (20%), Positives = 135/326 (41%), Gaps = 54/326 (16%)
Query: 218 ERECDRSSLEAKKAQWRKELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQS 277
E++ R ++ Q R+E +E+ + ++K E+ K+ + ++ W K
Sbjct: 410 EQQLRREQQLRREQQLRREQEEE---RHEQKHEQERREQRLKREQEERRDWLK------- 459
Query: 278 RETVLLEHPFSAVKQELQRKWIEELN----KQIEDDRQRKIEEKIIYSKGEEHDRWAMHF 333
RE H KQ+L+R EE K E++R+ + E + + E+ +R
Sbjct: 460 REEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRL 519
Query: 334 DSLKSYPGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKP 393
+ Q +L S+ ++ + E E+ + +
Sbjct: 520 KRQEEEERLQQRLRSEQQLRREQ--------------------------EERREQLLKRE 553
Query: 394 IKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEE 453
+ + ++ R D E +RR+Q+ Q+ Q ++ ++LE+E
Sbjct: 554 EEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE 613
Query: 454 QR-----KKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQEL 508
+R K+EE EEE R + E Q++ + L+++Q+E + + + + + L
Sbjct: 614 ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQE-----RREQRLKREEEEERL 668
Query: 509 AQRLK----QEQRIRELAQKGHDTSR 530
QRLK +E+R +ELA++ + +R
Sbjct: 669 EQRLKREHEEERREQELAEEEQEQAR 694
Score = 54.3 bits (129), Expect = 5e-07
Identities = 74/384 (19%), Positives = 163/384 (42%), Gaps = 50/384 (13%)
Query: 191 QETSKQC--EQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKE-LDEQVALKKKE 247
QE +QC E+++ E E + +E +R E ++ Q +E L + K++
Sbjct: 1104 QERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRR 1163
Query: 248 KEVSEKWNDPWK-KSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEE----L 302
+E+ ++ + + + E ++++ E+ + Q RE E ++ QR E+ L
Sbjct: 1164 QELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDL 1223
Query: 303 NKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLF-----------SQST 351
Q E +++ + + +Y KG E++++ DS SQ L Q
Sbjct: 1224 KWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQER 1283
Query: 352 HKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSM 411
+ + P+ ++L + EE+ + + ++ + R
Sbjct: 1284 RRWQQRDRHFPEEEQLEREEQ--KEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREE 1341
Query: 412 TALLD-----PAQIEERDRR-RQKQLEHQKAITAQVEEKRR------------------- 446
LL P + +ERDR+ R+++L HQ+ +EE++R
Sbjct: 1342 EQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRC 1401
Query: 447 ---KKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQ 503
++QL +++ +K +EE+ QER+ ++ E+ + +Q+++ + + + +L Q
Sbjct: 1402 QEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLE-EEQQLRQERH 1460
Query: 504 RAQELAQRLKQEQRIRELAQKGHD 527
R ++L QE+ ++L ++ D
Sbjct: 1461 RKFREEEQLLQEREEQQLHRQERD 1484
Score = 52.4 bits (124), Expect = 2e-06
Identities = 126/662 (19%), Positives = 256/662 (38%), Gaps = 51/662 (7%)
Query: 120 QDQLQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTEMVSSV 179
Q++ +Q L + R L +E + Q L + ++E L K+ E
Sbjct: 500 QERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLE 559
Query: 180 PAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDE 239
+ L QE + +Q + E E + + ER R E + ++E E
Sbjct: 560 QERREQRLKREQEERR--DQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERRE 617
Query: 240 QVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLL--EHPFSAVKQELQRK 297
Q LK++E E E+ K E ++ ++ + Q R L E ++Q L+R+
Sbjct: 618 Q-RLKREEPE-EERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKRE 675
Query: 298 WIEELNKQ-IEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPE 356
EE +Q + ++ Q + E+I +W +S QS+++S+ ++ +
Sbjct: 676 HEEERREQELAEEEQEQARERI----KSRIPKWQWQLES--EADARQSKVYSRPRKQEGQ 729
Query: 357 YFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLD 416
+ + S + +EE + A K + ++A
Sbjct: 730 RRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSAR-- 787
Query: 417 PAQIEERDRR---RQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEM 473
P E+R+R+ ++Q Q+ + + E+++R++Q E +++ + EEE +L +
Sbjct: 788 PPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQ 847
Query: 474 QKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIK 533
Q Q EED L++ Q+ Q +R Q+ +L++E++ R + L +
Sbjct: 848 QLQEEEDGLQEDQE--------RRRSQEQRRDQKWRWQLEEERKRRR--HTLYAKPALQE 897
Query: 534 NLGVDTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAES 593
L + ++ + + + Y +++ +Q ++ + + E
Sbjct: 898 QLRKEQQLLQEEEEELQREEREKRRRQEQERQY------REEEQLQQEEEQL-LREEREK 950
Query: 594 HCGSLMERDITNCSSPEISAE-LIGQFSTKKNKQ----------ELTQDKGASL--EKEN 640
ER + E L+G+ K+ +Q EL Q++ L E+E
Sbjct: 951 RRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREK 1010
Query: 641 NRCNDQCNQFTRIE--KQTKHMKKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEKKV 698
R + Q+ + + +Q + +R + + ++Y E ++ Q EE++
Sbjct: 1011 RRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERET 1070
Query: 699 RRQMELLHLVEKNNPGHLSQNRGISPEIFHSSHQETESKLR-WHLVKKEEEPLNIHSFSK 757
RR+ EL K + + + E QE E + R +++EEE L K
Sbjct: 1071 RRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREK 1130
Query: 758 ER 759
R
Sbjct: 1131 RR 1132
Score = 51.6 bits (122), Expect = 3e-06
Identities = 79/395 (20%), Positives = 172/395 (43%), Gaps = 74/395 (18%)
Query: 189 EHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDE---QVALKK 245
E +E ++ EQ++ E E + E E + L +++ Q R+E +E Q+ ++
Sbjct: 495 ERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQ-QLRREQEERREQLLKRE 553
Query: 246 KEKEVSEKWNDPWKKSESDKIIWEKHQIL---DQSRETVLLEHPFSAVKQELQRKWIEEL 302
+EK + ++ + K E ++ + Q+L ++ R+ L ++Q L+R+ +E L
Sbjct: 554 EEKRLEQERREQRLKREQEE---RRDQLLKREEERRQQRLKREQEERLEQRLKREEVERL 610
Query: 303 NKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSP 362
++ +++ K EE E +R S + Q QL + ++ +
Sbjct: 611 EQEERREQRLKREEP-------EEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREE 663
Query: 363 DTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQI-- 420
+ + L + E +EEE + ++ + + K + A +++
Sbjct: 664 EEERLEQRLKREHEEERREQELAEEEQ--EQARERIKSRIPKWQWQLESEADARQSKVYS 721
Query: 421 ------------EERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRK------------ 456
E+ ++RR+++ E Q Q EE+ ++Q EEEQR+
Sbjct: 722 RPRKQEGQRRRQEQEEKRRRRESELQ----WQEEERAHRQQQEEEQRRDFTWQWQAEEKS 777
Query: 457 -------------KEEQEEELRLAQEREEMQKQY--EEDILKQKQKE------EIMTLKT 495
+E++E +LR A+ER++ ++++ EE+ +Q++++ E+ L+
Sbjct: 778 ERGRQRLSARPPLREQRERQLR-AEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEE 836
Query: 496 NELFQTMQRAQELAQR---LKQEQRIRELAQKGHD 527
E Q +RAQ+L + L+++Q R ++ D
Sbjct: 837 EEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRD 871
Score = 44.7 bits (104), Expect = 4e-04
Identities = 35/156 (22%), Positives = 74/156 (47%), Gaps = 6/156 (3%)
Query: 370 VSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQK 429
V+ C G EE+ K+ ++ + ++ R + E RRRQK
Sbjct: 81 VAQACYYALGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQK 140
Query: 430 QLEHQKAITAQVEEKRRKKQLEEEQRKKEEQE--EELRLAQEREEMQKQYEE-DILKQKQ 486
+ E ++ + E+ ++++LE+ R++ ++E + + QEREE + + E+ K +
Sbjct: 141 RQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHE 200
Query: 487 KEEI---MTLKTNELFQTMQRAQELAQRLKQEQRIR 519
EE L+ EL + ++ +E Q+ ++E++ R
Sbjct: 201 TEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDR 236
Score = 38.9 bits (89), Expect = 0.022
Identities = 62/365 (16%), Positives = 156/365 (42%), Gaps = 57/365 (15%)
Query: 182 ENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQ- 240
E + +E + ++ EQ++ E E + + E E +R E +K Q +++ +E+
Sbjct: 428 EQEEERHEQKHEQERREQRLKREQEERRDWLKR---EEETERHEQERRKQQLKRDQEEER 484
Query: 241 ----VALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQR 296
+ L+++E+ ++ + + E ++ + Q L + E L+ + +Q+L+R
Sbjct: 485 RERWLKLEEEERREQQERREQQLRREQEE---RREQRLKRQEEEERLQQRLRS-EQQLRR 540
Query: 297 KWIEELNKQIEDDRQRKIEEKIIYS--KGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQ 354
+ E + ++ + ++++E++ K E+ +R LK + Q + ++
Sbjct: 541 EQEERREQLLKREEEKRLEQERREQRLKREQEER---RDQLLKREEERRQQRLKREQEER 597
Query: 355 PEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTAL 414
E + + L +EE + +K ++ L+S
Sbjct: 598 LEQRLKREEVERL-----------------EQEERREQRLKREEPEEERRQQLLKS---- 636
Query: 415 LDPAQIEERDRRRQKQLEHQKAITAQVE----------EKRRKKQLEEEQRKKE---EQE 461
EE++ RRQ+QL ++ + E+R K++ EEE+R++E E++
Sbjct: 637 ------EEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQ 690
Query: 462 EELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIREL 521
E+ R + + Q++ + ++ ++ + + Q ++ QE +R ++ + +
Sbjct: 691 EQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQE 750
Query: 522 AQKGH 526
++ H
Sbjct: 751 EERAH 755
Score = 38.1 bits (87), Expect = 0.038
Identities = 64/385 (16%), Positives = 148/385 (38%), Gaps = 31/385 (8%)
Query: 432 EHQKAITAQVEEKRRKKQLEEEQRKKEEQEEEL------RLAQEREEMQKQY---EEDIL 482
E ++A E + ++ EE+QR+ E ++ +L R Q+R+E +++ EE
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE 156
Query: 483 KQKQKEE-IMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRL-----IKNLG 536
KQ++ E+ + EL++ Q QE +R +E++++ KGH+T ++
Sbjct: 157 KQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSC--KGHETEEFPDEEQLRRRE 214
Query: 537 VDTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCG 596
+ ++ + R D + K++T ++ ++ +
Sbjct: 215 LLELRRKGREEKQQQRRERQDRV---FQEEEEKEWRKRETVLRKEEEKLQEEEPQRQREL 271
Query: 597 SLMERDITNCSSPEISAELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQ 656
E + E+ E + ++ + Q + E+ + ++ Q R E+Q
Sbjct: 272 QEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQ 331
Query: 657 TKHMKKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEKKVRRQMELLHLVEKNNPGHL 716
+ ++ +R + R E+ +QL++++EE++ +Q+ + +
Sbjct: 332 EERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRR 391
Query: 717 SQNRGISPEIFHSSHQETESKLRWHLVKKEEEPLNIHSFSKERSPSSPVPVVKNRTQQTQ 776
Q ++ E +LR + E+ L +E+ ++ + Q
Sbjct: 392 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLR-----REQEEE------RHEQKHEQ 440
Query: 777 NTLHLPLKNSSYERENLISGSNQTE 801
LK ER + + +TE
Sbjct: 441 ERREQRLKREQEERRDWLKREEETE 465
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 68.2 bits (165), Expect = 3e-11
Identities = 75/374 (20%), Positives = 175/374 (46%), Gaps = 41/374 (10%)
Query: 162 KDENIMGLFKKTEMVSSVPAENKSVLNEHQETSKQCEQKIAIENE---WKPADIFSTLGE 218
K+E I L +K + + + + QE K EQ+ E E W+ +
Sbjct: 389 KEEKIRELEEKMHEQEKIREQEE----KRQEEEKIREQEKRQEQEAKMWRQEEKI----- 439
Query: 219 RECDRSSLEAKKAQWRKE--LDEQVALKKKEK--EVSEKWNDPWKKSESDKIIWEKHQIL 274
RE + E +K WR+E + EQ ++++EK E E W K E ++I +K ++
Sbjct: 440 REQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMH 499
Query: 275 DQSRETVLLEHPFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFD 334
+Q + ++++ ++ W +E + ++++ R+ EEK+ + + ++ M +
Sbjct: 500 EQEEK----------IRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWRE 549
Query: 335 SLKSYPGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPI 394
K + Q +++ + ++ E + + V Q E E+ +
Sbjct: 550 EEKMH--EQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWR-----QEEKIREQEEKRQE 602
Query: 395 KDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEK---RRKKQLE 451
++ M K+ +R + + EE+ R +++++ Q+ +T + EEK + +K E
Sbjct: 603 QEEKMW--KQEEKIREQEEKIQ--EQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCE 658
Query: 452 EEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQR 511
+E++ +E++E R ++ E +K+ E K +++EE+M + ++++ ++ E ++
Sbjct: 659 QEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 718
Query: 512 LK-QEQRIRELAQK 524
++ QE+++R +K
Sbjct: 719 MQEQEEKMRRQEEK 732
Score = 59.3 bits (142), Expect = 2e-08
Identities = 103/502 (20%), Positives = 223/502 (44%), Gaps = 66/502 (13%)
Query: 83 NMQKTRNTVNTSLVGKQ--KPHKKHITAENMKSSLVCLTQD---QLQQILMTVNQGNRSL 137
+++ RNT+ + ++ K +K E+ KS + ++ +L++ + + Q
Sbjct: 206 SLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQA 265
Query: 138 SLTENGKE-----AKSQYSLYLNSI---SNQPKDENIMGLFKKTEMVSSVPAENKSVLNE 189
GKE AK Q + N + NQ ++E + +K + E + + E
Sbjct: 266 EADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE 325
Query: 190 HQETSKQCEQKIAIENE--WKPADIFSTLGER--ECDRSSLEAKKAQWRKE----LDEQV 241
+E ++ E+K+ + E W+ + E E + ++ W KE E++
Sbjct: 326 QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEM 385
Query: 242 ALKKKEK--EVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRK-W 298
+K+EK E+ EK ++ K E ++ E+ +I +Q + +QE + K W
Sbjct: 386 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK------------RQEQEAKMW 433
Query: 299 IEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQST--HKQPE 356
+E + ++++ R+ E+K+ + + H++ + + + Q +++ Q H+Q E
Sbjct: 434 RQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQ---EQEEMWRQEEKIHEQEE 490
Query: 357 YFCVSPDTQELADVSSVCTPTTGSQVEP--SEEEHIAKPIKDVVMANSK---KTNFLRSM 411
+ E + Q E +EE I + + + K + R
Sbjct: 491 IWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREE 550
Query: 412 TALLDPAQIEERDRRRQ---KQLEHQKAITAQVEEKRRKKQL---EEEQRKKEE-----Q 460
+ + +I E ++R++ K ++ I Q E+ R+++ +EE+R+++E Q
Sbjct: 551 EKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQ 610
Query: 461 EEELR----LAQEREEMQKQYEEDILKQ----KQKEEIMTLKTNELFQTMQRAQELAQRL 512
EE++R QE+EE ++ EE I +Q +++EE M + ++ + ++ QE + +
Sbjct: 611 EEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETM 670
Query: 513 -KQEQRIRELAQKGHDTSRLIK 533
+QE++IRE +K + I+
Sbjct: 671 WRQEEKIREQEKKIREQEEKIR 692
Score = 55.1 bits (131), Expect = 3e-07
Identities = 69/324 (21%), Positives = 141/324 (43%), Gaps = 69/324 (21%)
Query: 184 KSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQVAL 243
K ++E +E ++ E+K+ W+ + RE + E ++ WR+E
Sbjct: 495 KEKMHEQEEKIRKQEEKV-----WRQEEKI-----REQEEKIREQEEKMWRQE------- 537
Query: 244 KKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEELN 303
+K +E E W + K E +KI WE+ + +Q + E ++++ ++ W +E
Sbjct: 538 -EKIREQEEMWREEEKMHEQEKI-WEEEKRQEQEDKMWRQEEK---IREQEEKVWRQEEK 592
Query: 304 KQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSPD 363
+ +++++++ EEK+ K EE R Q + + K E +
Sbjct: 593 IREQEEKRQEQEEKMW--KQEEKIR-------------EQEEKIQEQEEKIREQEEKIRE 637
Query: 364 TQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEER 423
+E+ T Q E E+ ++ M ++T +
Sbjct: 638 QEEM----------TQEQEEKMGEQEEKMCEQEEKMQEQEETMW---------------- 671
Query: 424 DRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILK 483
R+ +K E +K I Q E+ R ++++ +EQ +K ++EE ++ ++ E+MQ+Q E K
Sbjct: 672 -RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEE-KMCEQEEKMQEQEE----K 725
Query: 484 QKQKEEIMTLKTNELFQTMQRAQE 507
+++EE M + L Q ++ QE
Sbjct: 726 MRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 54.7 bits (130), Expect = 4e-07
Identities = 76/398 (19%), Positives = 176/398 (44%), Gaps = 39/398 (9%)
Query: 154 LNSISNQPK--DENIMGLFKKTEMVSSVPAENKSVLNEHQETSKQCEQKIA-IENEWKPA 210
L++++ Q K D I L K+ + +S N E +E + + ++K+ +E+E
Sbjct: 181 LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEI 240
Query: 211 DIFSTLGERECDRSSLEAKKAQWRKELDE-----QVALKKKEKEVSEKWNDPWKK--SES 263
+ +R+ +R+ L + Q + E D Q K + +V E N+ W + +
Sbjct: 241 QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE--NELWNRLNQQQ 298
Query: 264 DKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKG 323
++ +W + + + + E + QE + K E+ K E + + + +E++++ K
Sbjct: 299 EEKMWRQEEKIQEWEEKI----------QEQEEKIREQEEKIREQEEKMRRQEEMMWEKE 348
Query: 324 EEHDRWAMHFDSLKSYPGSQSQLFSQSTHK---QPEYFCVSPDT-QELADVSSVCTPTTG 379
E+ R + Q ++ + K Q E + +EL +
Sbjct: 349 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIRE 408
Query: 380 SQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQ-IEERDRR--RQKQLEHQKA 436
+ + EEE I + K ++ R + + + I E++++ RQ++ H++
Sbjct: 409 QEEKRQEEEKIREQEK----RQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQE 464
Query: 437 ITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQ---EREEMQKQYEEDILKQKQKEEIMTL 493
+ E+++ ++++ ++ K EQEE R + E+EE ++ EE + +Q++K
Sbjct: 465 KIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEE 524
Query: 494 KTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRL 531
K E + M R +E ++++++ + +K H+ ++
Sbjct: 525 KIREQEEKMWRQEE---KIREQEEMWREEEKMHEQEKI 559
Score = 34.7 bits (78), Expect = 0.42
Identities = 24/140 (17%), Positives = 73/140 (52%), Gaps = 14/140 (10%)
Query: 182 ENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERE---CDRSSL--EAKKAQWRKE 236
E + + E +E ++ E+KI E E + +GE+E C++ E ++ WR+E
Sbjct: 616 EQEEKIQEQEEKIREQEEKIR-EQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQE 674
Query: 237 ---LDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQE 293
+++ ++++E+++ E+ E ++ +WE+ + + + E ++ ++++
Sbjct: 675 EKIREQEKKIREQEEKIREQEE---MMQEQEEKMWEQEEKMCEQEEK--MQEQEEKMRRQ 729
Query: 294 LQRKWIEELNKQIEDDRQRK 313
++ W +E+ + ++++ ++
Sbjct: 730 EEKMWEQEVRLRQQEEKMQE 749
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 67.8 bits (164), Expect = 4e-11
Identities = 86/374 (22%), Positives = 164/374 (43%), Gaps = 43/374 (11%)
Query: 173 TEMVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKK-A 231
TE+ +S P + + ++ Q E K AD G RE +S+ +
Sbjct: 406 TEIANSTPNPKPAASSPETPSAGQQEAKT------DQAD-----GPREPPQSARRKRSYK 454
Query: 232 QWRKELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVK 291
Q ELDE+ L+ +E + P + K++ L + +L P SA +
Sbjct: 455 QAVSELDEEQHLEDEELQPPRS-KTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPR 513
Query: 292 QELQR--------------KWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLK 337
++ ++E+ +++E+ R+++ E++ K EE R + LK
Sbjct: 514 SVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLK 573
Query: 338 SYPGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQV--EPSEEEHIAKPIK 395
+ L ++ +Q + Q+ A + ++ E ++++ AK ++
Sbjct: 574 REERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKME 633
Query: 396 DVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQL-----EHQKAITAQVEEKRRKKQL 450
+V A K+ R + L Q EE +RR Q+ L E Q+ + E KR +Q
Sbjct: 634 EVE-ARRKQEEEARRLRWL----QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQR 688
Query: 451 EEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQ 510
E+E+R++E +E+E R + RE+ +++ E + +Q+++ E L+ Q +E A
Sbjct: 689 EQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQ----EREKAL 744
Query: 511 RLKQEQRIRELAQK 524
RL++EQ REL +K
Sbjct: 745 RLQKEQLQRELEEK 758
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 67.4 bits (163), Expect = 6e-11
Identities = 88/427 (20%), Positives = 191/427 (44%), Gaps = 48/427 (11%)
Query: 122 QLQQILMTV----NQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTEMVS 177
+L+Q L V + +R + ++A S LY N+I+++ E L +K ++V
Sbjct: 164 ELEQALSAVATQKKKADRYIEELTKERDALS-LELYRNTITDEELKEKNAKLQEKLQLVE 222
Query: 178 SVPAE---NKSVLNEHQETSKQC--EQKIAIENEWKPADIFSTLGEREC--------DRS 224
S +E N L E +K +Q++ E + ++ S + + +R
Sbjct: 223 SEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRL 282
Query: 225 SLEAKKAQWRKELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLE 284
+ + ++ WR+E Q +K +++ + K ++++WEK + + + E +
Sbjct: 283 NQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMW-- 340
Query: 285 HPFSAVKQELQRKWIEELNKQ--IEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGS 342
K+E R+ E++++Q I + +++ EE+ I + + ++ A + +
Sbjct: 341 -----EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ 395
Query: 343 QSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANS 402
+ ++ Q Q + + +++ + + E E+E + ++ +
Sbjct: 396 EEKIREQEEMMQEQEEKMGEQEEKMWE----------QEEEMQEQEEKMRRQEEKIREQE 445
Query: 403 KKTNF----LRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKK- 457
KK +R ++ Q E+ + K E + + Q E+ RR+++ EQ KK
Sbjct: 446 KKIREQEEKIREQEEMMQE-QEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKI 504
Query: 458 EEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQR 517
EQEE++R E+EEM ++ EE + +Q++K K E + M+R +E + +QE R
Sbjct: 505 REQEEKIR---EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE--KMREQEVR 559
Query: 518 IRELAQK 524
+R+ +K
Sbjct: 560 LRQQEEK 566
Score = 63.5 bits (153), Expect = 8e-10
Identities = 86/391 (21%), Positives = 176/391 (45%), Gaps = 51/391 (13%)
Query: 154 LNSISNQPK--DENIMGLFKKTEMVSSVPAENKSVLNEHQETSKQCEQKIA-IENEWKPA 210
L++++ Q K D I L K+ + +S N E +E + + ++K+ +E+E
Sbjct: 169 LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEI 228
Query: 211 DIFSTLGERECDRSSLEAKKAQWRKELDE-----QVALKKKEKEVSEKWNDPWKK--SES 263
+ +R+ +R+ L + Q + E D Q K + +V E N+ W + +
Sbjct: 229 QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE--NELWNRLNQQQ 286
Query: 264 DKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKG 323
++ +W + + + Q RE + E +QE + + EE+ + E+ +R +E++++ K
Sbjct: 287 EEKMWRQEEKI-QEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRR--QEEMMWEKE 343
Query: 324 EEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVE 383
E+ L+ Q ++ Q +Q E Q +
Sbjct: 344 EK-------IRELEEKMHEQEKIREQEEKRQEE-------------------EKIREQEK 377
Query: 384 PSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEE 443
E+E ++ + +K +R ++ Q E+ + +K E ++ + Q E+
Sbjct: 378 RQEQEAKMWRQEEKIREQEEK---IREQEEMMQE-QEEKMGEQEEKMWEQEEEMQEQEEK 433
Query: 444 KRRKKQLEEEQRKK-EEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTM 502
RR+++ EQ KK EQEE++R E+EEM ++ EE + +Q+ K K E + M
Sbjct: 434 MRRQEEKIREQEKKIREQEEKIR---EQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKM 490
Query: 503 QRAQELAQRLKQEQRIRELAQKGHDTSRLIK 533
+R +E + +QE++IRE +K + +++
Sbjct: 491 RRQEEKIR--EQEKKIREQEEKIREQEEMMQ 519
Score = 59.3 bits (142), Expect = 2e-08
Identities = 77/419 (18%), Positives = 185/419 (44%), Gaps = 69/419 (16%)
Query: 83 NMQKTRNTVNTSLVGKQ--KPHKKHITAENMKSSLVCLTQD---QLQQILMTVNQGNRSL 137
+++ RNT+ + ++ K +K E+ KS + ++ +L++ + + Q
Sbjct: 194 SLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQA 253
Query: 138 SLTENGKE-----AKSQYSLYLNSISNQPKDENIMGLFKKTEMVSSVPAENKSVLNEHQE 192
GKE AK Q + N + N+ + ++++ E + E + + E +E
Sbjct: 254 EADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQ----EREEKIQEQEE 309
Query: 193 TSKQCEQKIAIENE--WKPADIFSTLGERECDRSSLEAKKAQWRKELDEQVALKKKE--K 248
++ E+K+ + E W+ + E ++ E K + +++ EQ ++++E +
Sbjct: 310 KIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEK---EEKIRELEEKMHEQEKIREQEEKR 366
Query: 249 EVSEKWNDPWKKSESDKIIWEKHQILDQSRETV-----LLEHPFSAVKQELQRKWIEELN 303
+ EK + K+ E + +W + + + + E + +++ + ++ ++ W +E
Sbjct: 367 QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEE 426
Query: 304 KQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSPD 363
Q ++++ R+ EEKI E+ + + ++ Q ++ + K E
Sbjct: 427 MQEQEEKMRRQEEKI----REQEKKIREQEEKIRE----QEEMMQEQEEKMGE------- 471
Query: 364 TQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEER 423
QE +C + + E+E + ++ + KK + EE+
Sbjct: 472 -QE----GKMCE----QEAKMQEQEEKMRRQEEKIREQEKKIR------------EQEEK 510
Query: 424 DRRRQKQLEHQKAITAQVEEK-----RRKKQLEEEQRKKEEQ--EEELRLAQEREEMQK 475
R +++ ++ Q+ + EEK + ++ EE+ R++EE+ E+E+RL Q+ E+MQ+
Sbjct: 511 IREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 50.8 bits (120), Expect = 6e-06
Identities = 62/293 (21%), Positives = 133/293 (45%), Gaps = 43/293 (14%)
Query: 283 LEHPFSAVKQELQR--KWIEELNKQIE----------------DDRQRKIEEKIIYSKGE 324
LE SAV + ++ ++IEEL K+ + ++ K++EK+ + E
Sbjct: 165 LEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESE 224
Query: 325 EHDRWAMHFDSLKSYPGS------QSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTT 378
+ + ++ LK Q QL +++ H E VS Q + + +
Sbjct: 225 KSEI-QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLN 283
Query: 379 GSQVEPS--EEEHIAKPIKDVVMANSKKTNFLRSMTALLDPA-QIEERDRRRQKQLEHQK 435
Q E +EE I + + + K M + + EE+ RR+++ + ++
Sbjct: 284 QQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKE 343
Query: 436 AITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQ----------KQYEEDILKQ- 484
++EEK +++ EQ +K ++EE++R ++R+E + ++ EE I +Q
Sbjct: 344 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 403
Query: 485 ---KQKEEIMTLKTNELFQTMQRAQELAQRL-KQEQRIRELAQKGHDTSRLIK 533
+++EE M + ++++ + QE +++ +QE++IRE +K + I+
Sbjct: 404 EMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIR 456
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 66.6 bits (161), Expect = 1e-10
Identities = 110/512 (21%), Positives = 227/512 (44%), Gaps = 80/512 (15%)
Query: 39 VGSETSQAKGEKNGMTFSSTKDLCKQCIDKDCLHIQKEISPATPNMQKTRNTVNTSLVGK 98
+ ET E N ++ +L K ++K+ L E+S + K +++ S
Sbjct: 819 LSQETKIQHEELNNRIQTTVTELQKVKMEKEAL--MTELSTVKDKLSKVSDSLKNSKSEF 876
Query: 99 QKPHKKHITA----ENMKSSLVCLTQDQLQQILMTVNQGNRSLSLTENGKEAKSQYSLYL 154
+K ++K A E L Q Q++ L + +SL E KEA Q L L
Sbjct: 877 EKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSL---EKEKEASHQLKLEL 933
Query: 155 NSISNQP-KDENIMGLFKKTEMVSSVPAENKSVLNEHQETSKQCEQKI-AIENEWKPADI 212
NS+ Q + +N + +K E + + +NE +++S+Q +++I A++ E K A +
Sbjct: 934 NSMQEQLIQAQNTLKQNEKEEQ------QLQGNINELKQSSEQKKKQIEALQGELKIAVL 987
Query: 213 FSTLGERECDRSSLEAKKAQWRKELDEQVALKKKEKEVS----EKWNDPWKKSESDKIIW 268
++ LE K Q + +++A +K++ V EK + +K+ +SD
Sbjct: 988 ---------QKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSD-FYG 1037
Query: 269 EKHQILDQSRETVLLEHPFSAVKQEL--QRKWIEELNKQIEDDRQRK--IEEKIIYSKGE 324
+ ++L ++ +E S +++L R I NK I++ + K +E+ + +
Sbjct: 1038 RESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQ 1097
Query: 325 EHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEP 384
+R D K + +L ++ + +LA++ +++
Sbjct: 1098 LQERCKALQDIQKEKSLKEKELVNEKS--------------KLAEIE---------EIKC 1134
Query: 385 SEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQ---KAITAQV 441
+E+ I K +++ S K ++ +T L D Q+ Q++LE Q ++ A V
Sbjct: 1135 RQEKEITKLNEEL---KSHKLESIKEITNLKDAKQL-----LIQQKLELQGKADSLKAAV 1186
Query: 442 EEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEE------IMTLKT 495
E+++R +Q+ ++Q KKEE+E + ++ ++ + +E + K+ EE +
Sbjct: 1187 EQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITAL 1246
Query: 496 NELFQTMQRAQELAQRLKQEQRIRELAQKGHD 527
NE T+++ + +QR R+ EL ++ D
Sbjct: 1247 NENLGTVKKEWQSSQR-----RVSELEKQTDD 1273
Score = 65.9 bits (159), Expect = 2e-10
Identities = 181/939 (19%), Positives = 349/939 (37%), Gaps = 156/939 (16%)
Query: 13 RTKTGHILKSTQDTCIGSEKLLQKKPVGSETSQAKGEKNGMTFSSTKDLCKQCIDKDCLH 72
+T T ++LK QD EK ++ +KN KDL DC
Sbjct: 305 QTLTENLLKKEQDYTKLEEK---------HNEESVSKKNIQATLHQKDL-------DCQQ 348
Query: 73 IQKEISPATPNMQKTRNTVNTSLVGKQKPHKKHITAENMKSSLVCLTQDQLQQILMTVNQ 132
+Q +S + TSL H+ H+ K +++L ++
Sbjct: 349 LQSRLSAS-----------ETSL------HRIHVELSE-KGEATQKLKEELSEVETKYQH 390
Query: 133 GNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTEMVSSVPAENKSVLNEHQE 192
+ +E K Q+ L L S NQ + L + + K E
Sbjct: 391 LKAEFKQLQQQREEKEQHGLQLQSEINQLHSK----LLETERQLGEAHGRLKEQRQLSSE 446
Query: 193 TSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQVALKKKEK-EVS 251
EQ++A + + K + + L E+ + + L+ + + +++ EQ AL++ ++
Sbjct: 447 KLMDKEQQVA-DLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLR 505
Query: 252 EKWNDPWKK----SESDKIIWEKHQILDQSRETV-LLEHPFSAVKQELQRKWIEELNKQI 306
E ND + + D+ I +L +S+E + LLE + ++Q E
Sbjct: 506 EAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ 565
Query: 307 EDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSPDTQE 366
++ ++E++ + ++ H + ++ + + Q + E
Sbjct: 566 LQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNE 625
Query: 367 LADVSSVCTPTTGSQVEPSEEE------HIAKPIKDVVMANSKKTNFLRSMTALLDPAQ- 419
L SQ+ S+E+ I + ++ A + KT + LD AQ
Sbjct: 626 L-----------NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQN 674
Query: 420 -IEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQ---K 475
++++ + K +TA++++K+ + E KE +E+ L L Q+ EE++ K
Sbjct: 675 ALQDKQQELNKITTQLDQVTAKLQDKQEHCS-QLESHLKEYKEKYLSLEQKTEELEGQIK 733
Query: 476 QYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIKNL 535
+ E D L+ K +E + Q +Q+ ++L L E R EL+++ ++ +
Sbjct: 734 KLEADSLEVKASKE-------QALQDLQQQRQLNTDL--ELRATELSKQLEMEKEIVSST 784
Query: 536 GVDTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHC 595
+D + +I +E K + T ++T +Q ++LN I T
Sbjct: 785 RLDLQKKSEALESIKQKLTKQEE--EKQILKQDFETLSQETKIQHEELNNRIQTTVTELQ 842
Query: 596 GSLMERDITNCSSPEISAELIGQFSTKKNKQELTQDK----GASLEKENNRCNDQCNQFT 651
ME++ L+ + ST K+K D + EKEN +
Sbjct: 843 KVKMEKEA-----------LMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLE 891
Query: 652 RIEKQTKHMKKYPKRPDWNINKPPKRYIPASEKYPKQLQKQ---REEKKVRRQMELLHLV 708
+ K+ KH + K K+ + ++ QL+ + +E+ ++ Q L
Sbjct: 892 KTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTL---- 947
Query: 709 EKNNPGHLSQNRGISPEIFHSSHQ--------------------ETESKLRWHLVKKEEE 748
K N Q +G E+ SS Q E E+KL+ L + +E
Sbjct: 948 -KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQE 1006
Query: 749 PLNIHSFSKERSPSSPVPVVKNRTQQTQNTLHLPLKNSSYERENLISGSNQTELSSGISE 808
+ KE+ + V++N +++Q T L++ Y RE+ + + Q +L S +
Sbjct: 1007 L----AAEKEK-----ISVLQNNYEKSQETFK-QLQSDFYGRESELLATRQ-DLKSVEEK 1055
Query: 809 SSHFIPYVRTNEIYYLDPDAPLSGPSTQDPQYQNSQDCGQKRQLFDSDCVRDPLLNPNMV 868
S Q+ N G + +L L +
Sbjct: 1056 LS-----------------------LAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSA 1092
Query: 869 KNRDRQQAILKGLSELRQGLLQKQKELESSLLPLAENQE 907
K + Q K L ++++ K+KEL + LAE +E
Sbjct: 1093 KKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEE 1131
Score = 47.0 bits (110), Expect = 8e-05
Identities = 74/360 (20%), Positives = 151/360 (41%), Gaps = 47/360 (13%)
Query: 408 LRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEEL-RL 466
L+S+ L+ AQ E + ++ K L QKA E K + +EE+ +E E+++ RL
Sbjct: 137 LQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRL 196
Query: 467 AQEREE---MQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELA-QRLKQEQRIRELA 522
+E + + + + ++L++ E++ LK EL Q + +R ++ +++++
Sbjct: 197 TEELNKEATVIQDLKTELLQRPGIEDVAVLK-KELVQVQTLMDNMTLERERESEKLKDEC 255
Query: 523 QKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDEISG--KMNTYMNSTTSKKDTGVQT 580
+K +Q +Y +S + S+ S+ G ++ Y+ K + +
Sbjct: 256 KK---------------LQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNEL 300
Query: 581 DDLNIGIFTNAESHCGSLMERDITNCSSPEISAELIGQFSTKKNKQELTQDKGASLEKEN 640
N + N E+D T + +KKN Q K ++
Sbjct: 301 TQKNQTLTENLLK-----KEQDYTKLEEKHNEESV-----SKKNIQATLHQKDLDCQQLQ 350
Query: 641 NRCNDQCNQFTRIEKQTKHMKKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEK---- 696
+R + RI + + ++ +++ +Y ++ KQLQ+QREEK
Sbjct: 351 SRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEF-KQLQQQREEKEQHG 409
Query: 697 -KVRRQMELLH--LVEKNNP-----GHLSQNRGISPEIFHSSHQETESKLRWHLVKKEEE 748
+++ ++ LH L+E G L + R +S E Q+ + L+ L + EE+
Sbjct: 410 LQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQV-ADLQLKLSRLEEQ 468
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 65.9 bits (159), Expect = 2e-10
Identities = 87/371 (23%), Positives = 164/371 (44%), Gaps = 41/371 (11%)
Query: 173 TEMVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKK-A 231
TE+ +S P + + ++ Q E K AD G RE +S+ +
Sbjct: 406 TEIANSTPNPKPAASSPETPSAGQQEAKT------DQAD-----GPREPPQSARRKRSYK 454
Query: 232 QWRKELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVK 291
Q ELDE+ L+ +E + P + K++ L + +L P SA +
Sbjct: 455 QAVSELDEEQHLEDEELQPPRS-KTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPR 513
Query: 292 QELQRKWI-----------EELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYP 340
+ + +I E+ +++E+ R+++ E++ K EE R + LK
Sbjct: 514 S-VMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREE 572
Query: 341 GSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQV--EPSEEEHIAKPIKDVV 398
+ L ++ +Q + Q+ A + ++ E ++++ AK +++V
Sbjct: 573 RLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVE 632
Query: 399 MANSKKTNFLRSMTALLDPAQIEERDRRRQKQL-----EHQKAITAQVEEKRRKKQLEEE 453
A K+ R + L Q EE +RR Q+ L E Q+ + E KR +Q E+E
Sbjct: 633 -ARRKQEEEARRLRWL----QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQE 687
Query: 454 QRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLK 513
+R++E +E+E R + RE+ +++ E + +Q+++ E L+ Q +E A RL+
Sbjct: 688 RREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQ----EREKALRLQ 743
Query: 514 QEQRIRELAQK 524
+EQ REL +K
Sbjct: 744 KEQLQRELEEK 754
>gi|116174778 centrosome spindle pole associated protein 1 isoform b
[Homo sapiens]
Length = 1221
Score = 65.5 bits (158), Expect = 2e-10
Identities = 34/104 (32%), Positives = 66/104 (63%), Gaps = 1/104 (0%)
Query: 427 RQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQ 486
+Q++L ++ + Q+EEK+++++ E E+ + E++EE RLA++R +Q++YEE+ K+++
Sbjct: 730 KQQEL-YKNFLRFQIEEKKQREEAERERLRIAEEKEERRLAEQRARIQQEYEEEQEKKRE 788
Query: 487 KEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSR 530
KEE LK E + + Q+ A+R K+E+ + Q H R
Sbjct: 789 KEEEQRLKNEEHIRLAEERQKEAERKKKEEEEKYNLQLQHYCER 832
Score = 49.7 bits (117), Expect = 1e-05
Identities = 50/183 (27%), Positives = 84/183 (45%), Gaps = 13/183 (7%)
Query: 406 NFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELR 465
NFLR + + Q EE +R R + E ++ + R +++ EEEQ KK E+EEE R
Sbjct: 737 NFLRFQ--IEEKKQREEAERERLRIAEEKEERRLAEQRARIQQEYEEEQEKKREKEEEQR 794
Query: 466 LAQER-----EEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRE 520
L E EE QK+ E K+K++EE L+ + E + ++Q I
Sbjct: 795 LKNEEHIRLAEERQKEAER---KKKEEEEKYNLQLQHYCERDNLIGEETKHMRQPSPIVP 851
Query: 521 LAQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQT 580
A + S+L + VD+I + S SR S + + N + + KK+ ++
Sbjct: 852 -ALQNKIASKLQRPPSVDSIIRSF-IHESSMSRAQSPPVPARKN-QLRAEEEKKNVIMEL 908
Query: 581 DDL 583
++
Sbjct: 909 SEM 911
Score = 43.9 bits (102), Expect = 7e-04
Identities = 82/410 (20%), Positives = 159/410 (38%), Gaps = 59/410 (14%)
Query: 390 IAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLE-HQKAITAQVEEKRRKK 448
+A+P+ + V N K + S + E++ + ++ L+ +Q+A+ Q+ E+
Sbjct: 556 LAQPVVNTVGQNELK---ITSDQVINSGLIFEDKPKPSKQSLQSYQEALQQQIRER---- 608
Query: 449 QLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQEL 508
EE+RKKE +E+E A+ EM+ K + K N L
Sbjct: 609 ---EERRKKEREEKEEYEAKLEAEMRTYNPWG--KGGGGAPLRDAKGN-----------L 652
Query: 509 AQRLKQEQRIRELAQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDEISGKMNTYMN 568
L + R A D V ++ SN N +++ SG M T +
Sbjct: 653 ITDLNRMHRQNIDAYHNPDARTYEDKRAVVSLDPNLATSNAENLEDAANKSSGHMQTQSS 712
Query: 569 STTSKKDTGVQTDDLNIGIFTNAESHCGSLMERDITNCSSPEISAELIG-QFSTKKNKQE 627
G +L I E+ + Q KK ++E
Sbjct: 713 PFARGNVFGEPPTELQI---------------------KQQELYKNFLRFQIEEKKQREE 751
Query: 628 LTQDK-GASLEKENNRCNDQCNQFTRIEKQTKHMKKYPKRPDWNINKPPKRYIPASEKYP 686
+++ + EKE R +Q + + E + + KK K + + + +I +E+
Sbjct: 752 AERERLRIAEEKEERRLAEQRARIQQ-EYEEEQEKKREKEEEQRLKN--EEHIRLAEERQ 808
Query: 687 KQLQKQREEKKVRRQMELLHLVEKNN-----PGHLSQNRGISPEIFHSSHQETESKLRWH 741
K+ +++++E++ + ++L H E++N H+ Q I P + + SKL+
Sbjct: 809 KEAERKKKEEEEKYNLQLQHYCERDNLIGEETKHMRQPSPIVPAL----QNKIASKLQRP 864
Query: 742 LVKKEEEPLNIHSFSKERSPSSPVPVVKNRTQQTQNTLHLPLKNSSYERE 791
IH S R+ S PVP KN+ + + ++ ++ S ++
Sbjct: 865 PSVDSIIRSFIHESSMSRAQSPPVPARKNQLRAEEEKKNVIMELSEMRKQ 914
>gi|116174789 centrosome spindle pole associated protein 1 isoform a
[Homo sapiens]
Length = 1256
Score = 65.5 bits (158), Expect = 2e-10
Identities = 34/104 (32%), Positives = 66/104 (63%), Gaps = 1/104 (0%)
Query: 427 RQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQ 486
+Q++L ++ + Q+EEK+++++ E E+ + E++EE RLA++R +Q++YEE+ K+++
Sbjct: 765 KQQEL-YKNFLRFQIEEKKQREEAERERLRIAEEKEERRLAEQRARIQQEYEEEQEKKRE 823
Query: 487 KEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSR 530
KEE LK E + + Q+ A+R K+E+ + Q H R
Sbjct: 824 KEEEQRLKNEEHIRLAEERQKEAERKKKEEEEKYNLQLQHYCER 867
Score = 49.7 bits (117), Expect = 1e-05
Identities = 50/183 (27%), Positives = 84/183 (45%), Gaps = 13/183 (7%)
Query: 406 NFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELR 465
NFLR + + Q EE +R R + E ++ + R +++ EEEQ KK E+EEE R
Sbjct: 772 NFLRFQ--IEEKKQREEAERERLRIAEEKEERRLAEQRARIQQEYEEEQEKKREKEEEQR 829
Query: 466 LAQER-----EEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRE 520
L E EE QK+ E K+K++EE L+ + E + ++Q I
Sbjct: 830 LKNEEHIRLAEERQKEAER---KKKEEEEKYNLQLQHYCERDNLIGEETKHMRQPSPIVP 886
Query: 521 LAQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQT 580
A + S+L + VD+I + S SR S + + N + + KK+ ++
Sbjct: 887 -ALQNKIASKLQRPPSVDSIIRSF-IHESSMSRAQSPPVPARKN-QLRAEEEKKNVIMEL 943
Query: 581 DDL 583
++
Sbjct: 944 SEM 946
Score = 43.9 bits (102), Expect = 7e-04
Identities = 82/410 (20%), Positives = 159/410 (38%), Gaps = 59/410 (14%)
Query: 390 IAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLE-HQKAITAQVEEKRRKK 448
+A+P+ + V N K + S + E++ + ++ L+ +Q+A+ Q+ E+
Sbjct: 591 LAQPVVNTVGQNELK---ITSDQVINSGLIFEDKPKPSKQSLQSYQEALQQQIRER---- 643
Query: 449 QLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQEL 508
EE+RKKE +E+E A+ EM+ K + K N L
Sbjct: 644 ---EERRKKEREEKEEYEAKLEAEMRTYNPWG--KGGGGAPLRDAKGN-----------L 687
Query: 509 AQRLKQEQRIRELAQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDEISGKMNTYMN 568
L + R A D V ++ SN N +++ SG M T +
Sbjct: 688 ITDLNRMHRQNIDAYHNPDARTYEDKRAVVSLDPNLATSNAENLEDAANKSSGHMQTQSS 747
Query: 569 STTSKKDTGVQTDDLNIGIFTNAESHCGSLMERDITNCSSPEISAELIG-QFSTKKNKQE 627
G +L I E+ + Q KK ++E
Sbjct: 748 PFARGNVFGEPPTELQI---------------------KQQELYKNFLRFQIEEKKQREE 786
Query: 628 LTQDK-GASLEKENNRCNDQCNQFTRIEKQTKHMKKYPKRPDWNINKPPKRYIPASEKYP 686
+++ + EKE R +Q + + E + + KK K + + + +I +E+
Sbjct: 787 AERERLRIAEEKEERRLAEQRARIQQ-EYEEEQEKKREKEEEQRLKN--EEHIRLAEERQ 843
Query: 687 KQLQKQREEKKVRRQMELLHLVEKNN-----PGHLSQNRGISPEIFHSSHQETESKLRWH 741
K+ +++++E++ + ++L H E++N H+ Q I P + + SKL+
Sbjct: 844 KEAERKKKEEEEKYNLQLQHYCERDNLIGEETKHMRQPSPIVPAL----QNKIASKLQRP 899
Query: 742 LVKKEEEPLNIHSFSKERSPSSPVPVVKNRTQQTQNTLHLPLKNSSYERE 791
IH S R+ S PVP KN+ + + ++ ++ S ++
Sbjct: 900 PSVDSIIRSFIHESSMSRAQSPPVPARKNQLRAEEEKKNVIMELSEMRKQ 949
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sapiens]
Length = 1293
Score = 65.1 bits (157), Expect = 3e-10
Identities = 61/289 (21%), Positives = 134/289 (46%), Gaps = 16/289 (5%)
Query: 418 AQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQY 477
A+ EE +R+RQ++L Q+ + +++ +K+ EEE+ + +QEE LR +E+E ++
Sbjct: 742 AKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQ 801
Query: 478 EEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIKNLGV 537
E+ +Q+Q+E + L+ + +R QE R KQE+ + A++ + R ++
Sbjct: 802 REEEERQQQEEALRRLEERRREEEERRKQEELLR-KQEEEAAKWAREEEEAQRRLEE--- 857
Query: 538 DTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCGS 597
+ ++ME A+ + RH+ +E K + Q + L +
Sbjct: 858 NRLRMEEEAARL---RHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQ 914
Query: 598 LMERDITNCSSPEISAELIGQFSTKKNK-QELTQDKGASLEKENNRCNDQCNQFTRIEKQ 656
+ + + Q + + Q+L +++ L +E R Q +++Q
Sbjct: 915 MKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRR--QQRELMKALQQQ 972
Query: 657 TKHMKKYPKRPDW-NINKP---PKRYIPASEKYPKQLQKQREEKKVRRQ 701
+ ++ K W N++KP K + ++ +Q+QKQ+++++ +Q
Sbjct: 973 QQQQQQ--KLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQ 1019
Score = 61.6 bits (148), Expect = 3e-09
Identities = 44/156 (28%), Positives = 85/156 (54%), Gaps = 25/156 (16%)
Query: 386 EEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKR 445
++E K ++ +A K+ LR +I R +R +++ + Q+ ++EE+R
Sbjct: 766 QQEEERKRREEEELARRKQEEALRRQRE----QEIALRRQREEEERQQQEEALRRLEERR 821
Query: 446 RKKQLEEEQRKKEE-----QEEELRLAQEREEMQKQYEEDILK-------------QKQK 487
R+ EEE+RK+EE +EE + A+E EE Q++ EE+ L+ ++++
Sbjct: 822 RE---EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKR 878
Query: 488 EEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQ 523
+E+ + EL + Q+ QE +RL+Q+Q+ ++LAQ
Sbjct: 879 KELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQ 914
Score = 52.0 bits (123), Expect = 3e-06
Identities = 84/452 (18%), Positives = 176/452 (38%), Gaps = 72/452 (15%)
Query: 220 ECDRSSLEAKKAQWRKELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQ---ILDQ 276
E +R E + + +E Q L+++++E+ + + +K ++ + + Q + Q
Sbjct: 732 EQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQ 791
Query: 277 SRETVLLEHPFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSL 336
+ + L +++ Q + + L ++ ++ +R+ +E+++ + EE +WA +
Sbjct: 792 REQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEE- 850
Query: 337 KSYPGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPI-- 394
+Q +L + E +++ EEE K +
Sbjct: 851 -----AQRRLEENRLRMEEE----------------------AARLRHEEEERKRKELEV 883
Query: 395 ---KDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITA------------ 439
K+++ ++ LR + Q+ + Q TA
Sbjct: 884 QRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEI 943
Query: 440 -QVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNEL 498
++EE+R + QL EEQR+ Q+ EL A ++++ Q+Q + K T E+
Sbjct: 944 QKLEEERER-QLREEQRR---QQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEI 999
Query: 499 FQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDE 558
Q +E Q KQ+Q+ ++ Q + NL ++I NS S
Sbjct: 1000 QQ-----EEARQMQKQQQQQQQHQQPNRARNNTHSNL----------HTSIGNSVWGSIN 1044
Query: 559 ISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCGSLMERDITNCSSPEISAELIGQ 618
+G N + + S + T + N+G + +A G R+ TN + S
Sbjct: 1045 -TGPPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVG---PRNSTNKNKNNASLSKSVG 1100
Query: 619 FSTKKNKQELTQDKGASLEKENNRCNDQCNQF 650
S ++NK+ ++K L + N+ D Q+
Sbjct: 1101 VSNRQNKKVEEEEKLLKLFQGVNKAQDGFTQW 1132
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sapiens]
Length = 1320
Score = 65.1 bits (157), Expect = 3e-10
Identities = 61/289 (21%), Positives = 134/289 (46%), Gaps = 16/289 (5%)
Query: 418 AQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQY 477
A+ EE +R+RQ++L Q+ + +++ +K+ EEE+ + +QEE LR +E+E ++
Sbjct: 769 AKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQ 828
Query: 478 EEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIKNLGV 537
E+ +Q+Q+E + L+ + +R QE R KQE+ + A++ + R ++
Sbjct: 829 REEEERQQQEEALRRLEERRREEEERRKQEELLR-KQEEEAAKWAREEEEAQRRLEE--- 884
Query: 538 DTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCGS 597
+ ++ME A+ + RH+ +E K + Q + L +
Sbjct: 885 NRLRMEEEAARL---RHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQ 941
Query: 598 LMERDITNCSSPEISAELIGQFSTKKNK-QELTQDKGASLEKENNRCNDQCNQFTRIEKQ 656
+ + + Q + + Q+L +++ L +E R Q +++Q
Sbjct: 942 MKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRR--QQRELMKALQQQ 999
Query: 657 TKHMKKYPKRPDW-NINKP---PKRYIPASEKYPKQLQKQREEKKVRRQ 701
+ ++ K W N++KP K + ++ +Q+QKQ+++++ +Q
Sbjct: 1000 QQQQQQ--KLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQ 1046
Score = 61.6 bits (148), Expect = 3e-09
Identities = 44/156 (28%), Positives = 85/156 (54%), Gaps = 25/156 (16%)
Query: 386 EEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKR 445
++E K ++ +A K+ LR +I R +R +++ + Q+ ++EE+R
Sbjct: 793 QQEEERKRREEEELARRKQEEALRRQRE----QEIALRRQREEEERQQQEEALRRLEERR 848
Query: 446 RKKQLEEEQRKKEE-----QEEELRLAQEREEMQKQYEEDILK-------------QKQK 487
R+ EEE+RK+EE +EE + A+E EE Q++ EE+ L+ ++++
Sbjct: 849 RE---EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKR 905
Query: 488 EEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQ 523
+E+ + EL + Q+ QE +RL+Q+Q+ ++LAQ
Sbjct: 906 KELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQ 941
Score = 52.0 bits (123), Expect = 3e-06
Identities = 84/452 (18%), Positives = 176/452 (38%), Gaps = 72/452 (15%)
Query: 220 ECDRSSLEAKKAQWRKELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQ---ILDQ 276
E +R E + + +E Q L+++++E+ + + +K ++ + + Q + Q
Sbjct: 759 EQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQ 818
Query: 277 SRETVLLEHPFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSL 336
+ + L +++ Q + + L ++ ++ +R+ +E+++ + EE +WA +
Sbjct: 819 REQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEE- 877
Query: 337 KSYPGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPI-- 394
+Q +L + E +++ EEE K +
Sbjct: 878 -----AQRRLEENRLRMEEE----------------------AARLRHEEEERKRKELEV 910
Query: 395 ---KDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITA------------ 439
K+++ ++ LR + Q+ + Q TA
Sbjct: 911 QRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEI 970
Query: 440 -QVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNEL 498
++EE+R + QL EEQR+ Q+ EL A ++++ Q+Q + K T E+
Sbjct: 971 QKLEEERER-QLREEQRR---QQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEI 1026
Query: 499 FQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDE 558
Q +E Q KQ+Q+ ++ Q + NL ++I NS S
Sbjct: 1027 QQ-----EEARQMQKQQQQQQQHQQPNRARNNTHSNL----------HTSIGNSVWGSIN 1071
Query: 559 ISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCGSLMERDITNCSSPEISAELIGQ 618
+G N + + S + T + N+G + +A G R+ TN + S
Sbjct: 1072 -TGPPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVG---PRNSTNKNKNNASLSKSVG 1127
Query: 619 FSTKKNKQELTQDKGASLEKENNRCNDQCNQF 650
S ++NK+ ++K L + N+ D Q+
Sbjct: 1128 VSNRQNKKVEEEEKLLKLFQGVNKAQDGFTQW 1159
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
Length = 1299
Score = 65.1 bits (157), Expect = 3e-10
Identities = 61/289 (21%), Positives = 134/289 (46%), Gaps = 16/289 (5%)
Query: 418 AQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQY 477
A+ EE +R+RQ++L Q+ + +++ +K+ EEE+ + +QEE LR +E+E ++
Sbjct: 748 AKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQ 807
Query: 478 EEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIKNLGV 537
E+ +Q+Q+E + L+ + +R QE R KQE+ + A++ + R ++
Sbjct: 808 REEEERQQQEEALRRLEERRREEEERRKQEELLR-KQEEEAAKWAREEEEAQRRLEE--- 863
Query: 538 DTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCGS 597
+ ++ME A+ + RH+ +E K + Q + L +
Sbjct: 864 NRLRMEEEAARL---RHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQ 920
Query: 598 LMERDITNCSSPEISAELIGQFSTKKNK-QELTQDKGASLEKENNRCNDQCNQFTRIEKQ 656
+ + + Q + + Q+L +++ L +E R Q +++Q
Sbjct: 921 MKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRR--QQRELMKALQQQ 978
Query: 657 TKHMKKYPKRPDW-NINKP---PKRYIPASEKYPKQLQKQREEKKVRRQ 701
+ ++ K W N++KP K + ++ +Q+QKQ+++++ +Q
Sbjct: 979 QQQQQQ--KLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQ 1025
Score = 61.6 bits (148), Expect = 3e-09
Identities = 44/156 (28%), Positives = 85/156 (54%), Gaps = 25/156 (16%)
Query: 386 EEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKR 445
++E K ++ +A K+ LR +I R +R +++ + Q+ ++EE+R
Sbjct: 772 QQEEERKRREEEELARRKQEEALRRQRE----QEIALRRQREEEERQQQEEALRRLEERR 827
Query: 446 RKKQLEEEQRKKEE-----QEEELRLAQEREEMQKQYEEDILK-------------QKQK 487
R+ EEE+RK+EE +EE + A+E EE Q++ EE+ L+ ++++
Sbjct: 828 RE---EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKR 884
Query: 488 EEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQ 523
+E+ + EL + Q+ QE +RL+Q+Q+ ++LAQ
Sbjct: 885 KELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQ 920
Score = 52.0 bits (123), Expect = 3e-06
Identities = 84/452 (18%), Positives = 176/452 (38%), Gaps = 72/452 (15%)
Query: 220 ECDRSSLEAKKAQWRKELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQ---ILDQ 276
E +R E + + +E Q L+++++E+ + + +K ++ + + Q + Q
Sbjct: 738 EQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQ 797
Query: 277 SRETVLLEHPFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSL 336
+ + L +++ Q + + L ++ ++ +R+ +E+++ + EE +WA +
Sbjct: 798 REQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEE- 856
Query: 337 KSYPGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPI-- 394
+Q +L + E +++ EEE K +
Sbjct: 857 -----AQRRLEENRLRMEEE----------------------AARLRHEEEERKRKELEV 889
Query: 395 ---KDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITA------------ 439
K+++ ++ LR + Q+ + Q TA
Sbjct: 890 QRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEI 949
Query: 440 -QVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNEL 498
++EE+R + QL EEQR+ Q+ EL A ++++ Q+Q + K T E+
Sbjct: 950 QKLEEERER-QLREEQRR---QQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEI 1005
Query: 499 FQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDE 558
Q +E Q KQ+Q+ ++ Q + NL ++I NS S
Sbjct: 1006 QQ-----EEARQMQKQQQQQQQHQQPNRARNNTHSNL----------HTSIGNSVWGSIN 1050
Query: 559 ISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCGSLMERDITNCSSPEISAELIGQ 618
+G N + + S + T + N+G + +A G R+ TN + S
Sbjct: 1051 -TGPPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVG---PRNSTNKNKNNASLSKSVG 1106
Query: 619 FSTKKNKQELTQDKGASLEKENNRCNDQCNQF 650
S ++NK+ ++K L + N+ D Q+
Sbjct: 1107 VSNRQNKKVEEEEKLLKLFQGVNKAQDGFTQW 1138
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
Length = 1299
Score = 65.1 bits (157), Expect = 3e-10
Identities = 61/289 (21%), Positives = 134/289 (46%), Gaps = 16/289 (5%)
Query: 418 AQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQY 477
A+ EE +R+RQ++L Q+ + +++ +K+ EEE+ + +QEE LR +E+E ++
Sbjct: 748 AKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQ 807
Query: 478 EEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIKNLGV 537
E+ +Q+Q+E + L+ + +R QE R KQE+ + A++ + R ++
Sbjct: 808 REEEERQQQEEALRRLEERRREEEERRKQEELLR-KQEEEAAKWAREEEEAQRRLEE--- 863
Query: 538 DTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCGS 597
+ ++ME A+ + RH+ +E K + Q + L +
Sbjct: 864 NRLRMEEEAARL---RHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQ 920
Query: 598 LMERDITNCSSPEISAELIGQFSTKKNK-QELTQDKGASLEKENNRCNDQCNQFTRIEKQ 656
+ + + Q + + Q+L +++ L +E R Q +++Q
Sbjct: 921 MKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRR--QQRELMKALQQQ 978
Query: 657 TKHMKKYPKRPDW-NINKP---PKRYIPASEKYPKQLQKQREEKKVRRQ 701
+ ++ K W N++KP K + ++ +Q+QKQ+++++ +Q
Sbjct: 979 QQQQQQ--KLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQ 1025
Score = 61.6 bits (148), Expect = 3e-09
Identities = 44/156 (28%), Positives = 85/156 (54%), Gaps = 25/156 (16%)
Query: 386 EEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKR 445
++E K ++ +A K+ LR +I R +R +++ + Q+ ++EE+R
Sbjct: 772 QQEEERKRREEEELARRKQEEALRRQRE----QEIALRRQREEEERQQQEEALRRLEERR 827
Query: 446 RKKQLEEEQRKKEE-----QEEELRLAQEREEMQKQYEEDILK-------------QKQK 487
R+ EEE+RK+EE +EE + A+E EE Q++ EE+ L+ ++++
Sbjct: 828 RE---EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKR 884
Query: 488 EEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQ 523
+E+ + EL + Q+ QE +RL+Q+Q+ ++LAQ
Sbjct: 885 KELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQ 920
Score = 52.0 bits (123), Expect = 3e-06
Identities = 84/452 (18%), Positives = 176/452 (38%), Gaps = 72/452 (15%)
Query: 220 ECDRSSLEAKKAQWRKELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQ---ILDQ 276
E +R E + + +E Q L+++++E+ + + +K ++ + + Q + Q
Sbjct: 738 EQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQ 797
Query: 277 SRETVLLEHPFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSL 336
+ + L +++ Q + + L ++ ++ +R+ +E+++ + EE +WA +
Sbjct: 798 REQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEE- 856
Query: 337 KSYPGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPI-- 394
+Q +L + E +++ EEE K +
Sbjct: 857 -----AQRRLEENRLRMEEE----------------------AARLRHEEEERKRKELEV 889
Query: 395 ---KDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITA------------ 439
K+++ ++ LR + Q+ + Q TA
Sbjct: 890 QRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEI 949
Query: 440 -QVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNEL 498
++EE+R + QL EEQR+ Q+ EL A ++++ Q+Q + K T E+
Sbjct: 950 QKLEEERER-QLREEQRR---QQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEI 1005
Query: 499 FQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDE 558
Q +E Q KQ+Q+ ++ Q + NL ++I NS S
Sbjct: 1006 QQ-----EEARQMQKQQQQQQQHQQPNRARNNTHSNL----------HTSIGNSVWGSIN 1050
Query: 559 ISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCGSLMERDITNCSSPEISAELIGQ 618
+G N + + S + T + N+G + +A G R+ TN + S
Sbjct: 1051 -TGPPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVG---PRNSTNKNKNNASLSKSVG 1106
Query: 619 FSTKKNKQELTQDKGASLEKENNRCNDQCNQF 650
S ++NK+ ++K L + N+ D Q+
Sbjct: 1107 VSNRQNKKVEEEEKLLKLFQGVNKAQDGFTQW 1138
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 63.9 bits (154), Expect = 6e-10
Identities = 142/650 (21%), Positives = 258/650 (39%), Gaps = 143/650 (22%)
Query: 122 QLQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTEMVSSVPA 181
Q+Q++ V++G+R L + K +K Q L +N+ L ++ E A
Sbjct: 1260 QVQELHAKVSEGDR-LRVELAEKASKLQNEL-----------DNVSTLLEEAEKKGIKFA 1307
Query: 182 ENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQW---RKELD 238
++ + L E+ Q Q++ E + ++ S + + E +++SL+ ++ + RK L+
Sbjct: 1308 KDAASL----ESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLE 1363
Query: 239 EQV-ALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRK 297
+QV AL+ + + +K +D ES L+++++ +L
Sbjct: 1364 KQVLALQSQLADTKKKVDDDLGTIES----------LEEAKKKLL--------------- 1398
Query: 298 WIEELNKQIEDDRQRKIEEKIIYSKGEE-HDRWAMHFDSLKSYPGSQSQLFSQSTHKQPE 356
K E QR E+ + Y K E+ +R D L Q Q+ S KQ +
Sbjct: 1399 ------KDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKK 1452
Query: 357 YFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLD 416
+ Q LA+ S+ +EE A+ A K+T L AL +
Sbjct: 1453 F------DQLLAEEKSI-------SARYAEERDRAE-----AEAREKETKALSLARALEE 1494
Query: 417 PAQIEERDRRRQKQL----------------------EHQKAITAQVEEKRRKKQLEE-E 453
+ +E R+ KQL + ++A+ QVEE R QLEE E
Sbjct: 1495 ALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRT--QLEELE 1552
Query: 454 QRKKEEQEEELRLAQEREEMQKQYEEDIL----KQKQKEEIMTLKTNEL-----FQTMQR 504
+ ++ +LRL + M+ Q+E D+ + ++K+ ++ + EL + QR
Sbjct: 1553 DELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQR 1612
Query: 505 AQELAQRLKQEQRIREL------AQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDE 558
A +A + K E +++L A K D +IK L QM+ + +R DE
Sbjct: 1613 ALAVASKKKMEIDLKDLEAQIEAANKARD--EVIKQLRKLQAQMKDYQRELEEARASRDE 1670
Query: 559 ISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCGSLMERD-----ITNCSSPEIS- 612
I + S K + L + ++ + + ERD ITN +S + +
Sbjct: 1671 IFAQSK---ESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSAL 1727
Query: 613 -----------AELIGQFSTKKNKQELTQDK-----------GASLEKENNRCNDQCNQF 650
A+L + +++ EL D+ A L E + N
Sbjct: 1728 LDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNAR 1787
Query: 651 TRIEKQTKHMKKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEKKVRR 700
++E+Q K +K + + + K I A E QL++Q E++ R
Sbjct: 1788 QQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKER 1837
Score = 45.8 bits (107), Expect = 2e-04
Identities = 89/420 (21%), Positives = 177/420 (42%), Gaps = 74/420 (17%)
Query: 365 QELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERD 424
+EL V T G ++E E +H + ++A L++ T L A+ E R
Sbjct: 859 EELLKVKEKQTKVEG-ELEEMERKHQQLLEEKNILAEQ-----LQAETELFAEAE-EMRA 911
Query: 425 RRRQKQLEHQKAI---TAQVEEKRRKKQLEEEQRKK--------EEQEEELRLAQEREEM 473
R K+ E ++ + ++VEE+ + Q+ + ++KK EEQ +E A+++ ++
Sbjct: 912 RLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQL 971
Query: 474 QKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIK 533
+K E +K K +EEI+ L+ Q ++ + ++ E RI E + + + K
Sbjct: 972 EKVTAEAKIK-KMEEEILLLED-------QNSKFIKEKKLMEDRIAECSSQLAEEEEKAK 1023
Query: 534 NLGVDTIQMEYNASNI-------SNSRHDSDEISGKMNTYMNSTTSKKD----TGVQTDD 582
NL + E S++ +R + ++ K++ TT +D Q D+
Sbjct: 1024 NLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLD---GETTDLQDQIAELQAQIDE 1080
Query: 583 LNIGIFTNAESHCGSLMERD---ITNCSSPEISAELIGQFS---------------TKKN 624
L + + E G+L D + ++ ++ EL Q + +K
Sbjct: 1081 LKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQ 1140
Query: 625 KQELTQDKGA---SLEKENNRCNDQCNQFTRIEKQTKHMKK----YPKRPDWNINKPPKR 677
K++L+++ A LE + Q T+ E++ +KK K + I +R
Sbjct: 1141 KRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQR 1200
Query: 678 YIPASEKYPKQLQKQREEKKVRRQMELLHLVEKNNPGHLSQNRGISPEIFHSSHQETESK 737
+ A E+ +QL++ + K +EKN G + N+ ++ E+ + ES+
Sbjct: 1201 HATALEELSEQLEQAKRFKA---------NLEKNKQGLETDNKELACEVKVLQQVKAESE 1251
Score = 42.4 bits (98), Expect = 0.002
Identities = 41/157 (26%), Positives = 74/157 (47%), Gaps = 15/157 (9%)
Query: 419 QIEERDRRRQKQLEHQKAITAQVEEKRRK--KQLEEEQRKKEEQEEELRLAQEREEM--- 473
+++ +D K E Q + ++EE RK + LEE+ E+ + E L E EEM
Sbjct: 853 ELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRAR 912
Query: 474 ---QKQYEEDIL-----KQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKG 525
+KQ E+IL + +++EE + NE + Q+L ++L +E+ R+ Q
Sbjct: 913 LAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLE 972
Query: 526 HDTSRL-IKNLGVDTIQME-YNASNISNSRHDSDEIS 560
T+ IK + + + +E N+ I + D I+
Sbjct: 973 KVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIA 1009
Score = 42.4 bits (98), Expect = 0.002
Identities = 84/401 (20%), Positives = 156/401 (38%), Gaps = 64/401 (15%)
Query: 98 KQKPHKKHITAENMKSSLVCLTQDQLQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSI 157
+Q KK + + ++ L ++ Q+ L ++ + L K+ ++Q
Sbjct: 1585 EQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDL----KDLEAQIEA----- 1635
Query: 158 SNQPKDENIMGLFKKTEMVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLG 217
+N+ +DE I L K + A+ K E +E ++ IF+
Sbjct: 1636 ANKARDEVIKQLRK-------LQAQMKDYQRELEEARASRDE------------IFAQSK 1676
Query: 218 ERECDRSSLEAKKAQWRKELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQS 277
E E SLEA+ Q ++EL ++ ++ ++ D S S K +LD+
Sbjct: 1677 ESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGK-----SALLDEK 1731
Query: 278 RETVLLEHPFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLK 337
R LE + +++EL+ E+ N ++ +DR RK ++ E A + +
Sbjct: 1732 RR---LEARIAQLEEELEE---EQSNMELLNDRFRKTTLQVDTLNAE----LAAERSAAQ 1781
Query: 338 SYPGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSE---EEHIAKPI 394
++ QL Q+ + + QEL T S +E EE + +
Sbjct: 1782 KSDNARQQLERQNKELKAKL-------QELEGAVKSKFKATISALEAKIGQLEEQLEQEA 1834
Query: 395 KDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQ 454
K+ AN +R L ++ D RR ++ A K+ K+QLE
Sbjct: 1835 KERAAANK----LVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLE--- 1887
Query: 455 RKKEEQEEELRLAQEREEMQKQYEEDI-LKQKQKEEIMTLK 494
E +EE R R ++Q++ ++ + E+ TLK
Sbjct: 1888 ---EAEEEATRANASRRKLQRELDDATEANEGLSREVSTLK 1925
Score = 41.2 bits (95), Expect = 0.004
Identities = 129/685 (18%), Positives = 280/685 (40%), Gaps = 94/685 (13%)
Query: 73 IQKEISPATPNMQKTRNTVNTSLVGKQKPHKKHITAENMKSSLVCLTQDQLQQILMTVNQ 132
+Q E ++Q ++ +QK + +TAE + ++IL+ +Q
Sbjct: 941 LQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKME-------EEILLLEDQ 993
Query: 133 GNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTEMVSSVPAENKSVLNEHQE 192
++ + + ++ ++ S L + K +N+ + K E++ S E L + ++
Sbjct: 994 NSKFIKEKKLMEDRIAECSSQL--AEEEEKAKNLAKIRNKQEVMISDLEER---LKKEEK 1048
Query: 193 TSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQVALKKKEKEVSE 252
T ++ E K + + + D+ + E + L+ + A+ +EL Q AL + + E
Sbjct: 1049 TRQELE-KAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEEL--QGALARGDDETLH 1105
Query: 253 KWN-------------DPWKKSESDKIIWEK--HQILDQSRETVLLEHPF------SAVK 291
K N + + ES+K K Q D S E L+ +A +
Sbjct: 1106 KNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQ 1165
Query: 292 QELQ----------RKWIEELNK----QIEDDRQR----------KIEEKIIYSKGEEHD 327
QEL+ +K +EE K QI+D RQR ++E+ + E +
Sbjct: 1166 QELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKN 1225
Query: 328 RWAMHFDS--LKSYPGSQSQLFSQSTHKQPEYFCVSPDTQEL------ADVSSVCTPTTG 379
+ + D+ L Q+ ++S HK+ + + QEL D V
Sbjct: 1226 KQGLETDNKELACEVKVLQQVKAESEHKRKK---LDAQVQELHAKVSEGDRLRVELAEKA 1282
Query: 380 SQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITA 439
S+++ +E ++++ +++ K S+ + L Q ++ RQK +
Sbjct: 1283 SKLQ-NELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQL 1341
Query: 440 QVEEKRRKKQLEEEQRKKEEQEEE-LRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNEL 498
+ E+ ++Q EEE+ ++ E++ L L + + +K+ ++D+ + EE
Sbjct: 1342 EEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK------ 1395
Query: 499 FQTMQRAQELAQRLKQEQRIRELAQKGHD-TSRLIKNLGVDTIQMEYNASNISNSRHDSD 557
+ ++ A+ L+QRL+++ + +K + + + +L VD ASN+ + D
Sbjct: 1396 -KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFD 1454
Query: 558 EISGKMNTYMNSTTSKKDTG-VQTDDLNIGIFTNAESHCGSLMERDITNCSSPEISAELI 616
++ + + ++D + + + A + +L ++ + ++ A++
Sbjct: 1455 QLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME 1514
Query: 617 GQFSTK----KNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQTKHMKKYPKRPDWNIN 672
S+K KN EL + K A LE++ + Q +E + + + R + N+
Sbjct: 1515 DLMSSKDDVGKNVHELEKSKRA-LEQQ---VEEMRTQLEELEDELQATEDAKLRLEVNMQ 1570
Query: 673 KPPKRYIPASEKYPKQLQKQREEKK 697
++ E+ + +Q EEKK
Sbjct: 1571 AMKAQF----ERDLQTRDEQNEEKK 1591
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 63.5 bits (153), Expect = 8e-10
Identities = 80/370 (21%), Positives = 162/370 (43%), Gaps = 85/370 (22%)
Query: 169 LFKKTEMVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERE----CDRS 224
L KK E +S PA+ +L Q+ ++ E+K+ E E K + L +E ++S
Sbjct: 2059 LIKKRESLSKEPAKLNKILKALQKLTRD-ERKLTQE-EIKMTKMKRALFVKERRLSIEQS 2116
Query: 225 SLEAKK---AQWRKELD-EQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRET 280
L+ K+ ++ R EL ++ L +K+++++ K K E K+ E+ ++ + E
Sbjct: 2117 KLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEE--KMTEEESKLARKHSEV 2174
Query: 281 VLLEHPFSAVKQE-----LQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDS 335
+L + +++E L+R+W + + D + K ++ + EEH ++ +S
Sbjct: 2175 ILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEH--FSEEMES 2232
Query: 336 LKSYPGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIK 395
L Q L S+ ++ E E EEE +
Sbjct: 2233 LLDELEKQESLSSEEEEEREEE-------------------------EEREEEEVR---- 2263
Query: 396 DVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQR 455
EE + R++++ +K + + EEK++KK+ ++
Sbjct: 2264 -------------------------EEEEERKEEEEGEEKQVEKEEEEKKKKKK----EK 2294
Query: 456 KKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLK-- 513
KKEE +E+ + +E+EE+ + E + L +++EE ++ L + + R +E+ ++ K
Sbjct: 2295 KKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEE----ESCSLEEEVDREKEILKKEKQF 2350
Query: 514 --QEQRIREL 521
QEQR + L
Sbjct: 2351 KLQEQRRKSL 2360
Score = 60.8 bits (146), Expect = 5e-09
Identities = 160/823 (19%), Positives = 316/823 (38%), Gaps = 131/823 (15%)
Query: 63 KQCIDKDCLHIQKEISPATPNMQKTRNTVNTSLVGKQKPHKKHITAENMKSSLVCLTQDQ 122
+Q + ++ HIQ+E A + ++ R + ++ ++ A+ + + + +
Sbjct: 1558 EQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQ--LAQEERK 1615
Query: 123 LQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMG----LFKKTEMVSS 178
L Q + + Q +R ++ E GK A+ + +L + E + L KK E V+
Sbjct: 1616 LAQAYVKITQDDREMAQAE-GKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAR 1674
Query: 179 VP----------AENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEA 228
AE K++L + E Q EQ + +W+ ++ L E E D L
Sbjct: 1675 EEEKLAKKGGKLAEVKNILAQKVEELPQREQNL----DWQEKELAQELEELEWDMEELSW 1730
Query: 229 KKAQWRKELDEQVALKKK--EKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHP 286
K+ + +E + V KKK E+E + W K SE + + ++ ++L Q +E L +H
Sbjct: 1731 KEEELNQEEGKLVEEKKKLAEEEEALAWQRE-KLSEEETKLAQEEELLIQEKEK-LAQHK 1788
Query: 287 FSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQL 346
++E E L ++ R++ IE+K+ ++ +RW + L +
Sbjct: 1789 EKMPEEE------ERLGRK----REQLIEKKM--KLAQKRERWINSMEELTK----NKMI 1832
Query: 347 FSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTN 406
Q + E ++ + ++LA +E + K +V +K
Sbjct: 1833 LYQKKNLAQEKKNLAQEKEKLAQRKENLL---------YNKERLTHSKKQLVQVKNKLGM 1883
Query: 407 FLRSMTALLDPAQIEERD---RRRQKQLEHQKAITAQVEEKRRKKQLEEEQRK------- 456
F + A ++ +E++ ++++K E +K + QVE+ KKQ + Q K
Sbjct: 1884 F-NKILAQVEEKLTQEKETVIKKKEKLAETEKKLV-QVEDSLAKKQEKLAQEKMKLALEK 1941
Query: 457 -----KEEQEEELRLAQERE----EMQKQYEEDILKQKQKEEIM---TLKTNELFQTMQR 504
K+ EL +A+E + EM++ EE + + KE + T +T+ + Q
Sbjct: 1942 AMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQV 2001
Query: 505 AQELAQR--------LKQEQRI-----RELAQKGHDTSRLIKNLGVDTIQMEYNASNISN 551
QEL +R L E RI E+A+ + +R + ++ + +
Sbjct: 2002 EQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIK 2061
Query: 552 SRHDSDEISGKMNTYMNSTT--SKKDTGVQTDDLNIGIFTNAESHCGSLMERDITNCSSP 609
R + K+N + + ++ + + +++ + A + ER + S
Sbjct: 2062 KRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALF----VKERRL----SI 2113
Query: 610 EISAELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQTKHMKKYPKRPD- 668
E S I ++ + + ELT+D+ K+ N + EK T+ K ++
Sbjct: 2114 EQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSE 2173
Query: 669 -----------------------WNINKPPKRYIPASEKYPKQLQKQREEKKVRRQMELL 705
W K KR EK+ Q+ + E+ +ME L
Sbjct: 2174 VILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESL 2233
Query: 706 HLVEKNNPGHLSQNRGISPEIFHSSHQETESKLRWHLVKKEEEPLNIHSFSKERSPSSPV 765
L + +S E +E E + V++EEE +E+
Sbjct: 2234 -------LDELEKQESLSSE--EEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEE 2284
Query: 766 PVVKNRTQQTQNTLHLPLKNSSYERENLISGSNQTELSSGISE 808
K + ++ + + K +E + I +TE S E
Sbjct: 2285 EEKKKKKKEKKKE-EVQEKEEVFEEKEEIMSEEETESLSDEEE 2326
Score = 56.6 bits (135), Expect = 1e-07
Identities = 101/448 (22%), Positives = 182/448 (40%), Gaps = 67/448 (14%)
Query: 133 GNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKK--TEMVSSVPAENKSVLNEH 190
GN ++ + KE K + + E +G K+ T+ + E + +
Sbjct: 1379 GNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLE 1438
Query: 191 QETSKQCEQKIAIEN-----EWKPA--DIFSTLGERECDRSSLEAKKAQWRKEL------ 237
++ KQ + + IE +WK A + GE R S +A K +W K L
Sbjct: 1439 EKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGET---RKSWKAWKEEWEKRLLQEEEK 1495
Query: 238 ---------DEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFS 288
E+ L++ +K E+W W+ S K ++ Q D+ E V LE S
Sbjct: 1496 LHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKS--KEQQYKDE--EEVTLEEEVS 1551
Query: 289 AVKQELQRKWIEELNKQIEDDRQRKIEEKIIYS---KGEEHDRWAMHFDSLKSYPGSQSQ 345
+E +++ EE E+ + +I K + + +E + A + L + Q
Sbjct: 1552 REGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQ---EERQ 1608
Query: 346 LFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEE------------EHIAKP 393
L + Y ++ D +E+A + + E+ + +AK
Sbjct: 1609 LAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKK 1668
Query: 394 IKDVVMAN---SKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEE---KRRK 447
+ V +KK L + +L ++EE +R Q +K + ++EE +
Sbjct: 1669 WEKVAREEEKLAKKGGKLAEVKNIL-AQKVEELPQREQNLDWQEKELAQELEELEWDMEE 1727
Query: 448 KQLEEEQRKKEE---QEEELRLAQEREEMQKQYE---EDILKQKQKEEIMTLKTNELFQT 501
+EE+ +EE EE+ +LA+E E + Q E E+ K Q+EE++ + +L Q
Sbjct: 1728 LSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQH 1787
Query: 502 MQRAQELAQRL--KQEQRIR---ELAQK 524
++ E +RL K+EQ I +LAQK
Sbjct: 1788 KEKMPEEEERLGRKREQLIEKKMKLAQK 1815
Score = 51.2 bits (121), Expect = 4e-06
Identities = 77/338 (22%), Positives = 140/338 (41%), Gaps = 51/338 (15%)
Query: 229 KKAQWRKELDE-QVALKKKEKEVS-EKWNDPWKKSESDKIIWEKHQILD-QSRETVLLEH 285
KKA+ L+E QV LKK +K + E N K S K + Q Q R+ V E
Sbjct: 1352 KKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKER 1411
Query: 286 PFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGE--------EHDRWAMHFDSLK 337
+K+E+ + EE + E + +EEK++ +G+ W +D K
Sbjct: 1412 KVGKIKREMTK---EERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWK 1468
Query: 338 SYPGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEE---------- 387
G + + + + + A G ++ P EE
Sbjct: 1469 QVHGETRKSWKAWKEEWEKRLLQEEEKLHQA----------GEKLSPEEEMLQEDKKLKW 1518
Query: 388 EHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAIT-----AQVE 442
E + ++++ + SK+ + L+ E + + Q+ E Q+ I A++
Sbjct: 1519 EEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIH 1578
Query: 443 EKR---RKKQLEEEQRKKEEQE----EELRLAQEREEMQKQY---EEDILKQKQKEEIMT 492
KR KK+ +EE++ +E+E EE +LAQE ++ + Y +D + Q E
Sbjct: 1579 RKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFA 1638
Query: 493 LKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSR 530
K L Q ++ + A++L Q++ ++LA+K +R
Sbjct: 1639 QKEETLAQRGEKLSQEAEKLAQKR--KKLAKKWEKVAR 1674
Score = 33.5 bits (75), Expect = 0.93
Identities = 93/522 (17%), Positives = 213/522 (40%), Gaps = 51/522 (9%)
Query: 31 EKLLQKKPVGSETSQAKGEKNGMTFSSTKDLCKQCIDKDCLHIQKEISPATPNM----QK 86
E+L +K+ E +K +S ++L K +K L+ +K ++ N+ +K
Sbjct: 1796 ERLGRKREQLIEKKMKLAQKRERWINSMEELTK---NKMILYQKKNLAQEKKNLAQEKEK 1852
Query: 87 TRNTVNTSLVGKQK---PHKKHITAEN---MKSSLVCLTQDQLQQILMTVNQGNRSLSLT 140
L K++ K+ + +N M + ++ +++L Q TV + L+ T
Sbjct: 1853 LAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAET 1912
Query: 141 ENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTEMVSSVPAENKSVLNE----HQETSKQ 196
E K + + SL K E + K + ++ K + E +E +
Sbjct: 1913 EK-KLVQVEDSL-------AKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALN 1964
Query: 197 CEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQ-VALKKK--------- 246
E K E + + + TL + E +S + K Q +EL E+ ++L++K
Sbjct: 1965 LEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRIL 2024
Query: 247 EKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEELNKQI 306
E SE + + +I + + L ++ ++ + + + K ++ L K
Sbjct: 2025 AMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLT 2084
Query: 307 EDDRQRKIEE----KIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSP 362
D+R+ EE K+ + + R ++ L S+ S+ T + + ++
Sbjct: 2085 RDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKK---LAR 2141
Query: 363 DTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEE 422
++LA+ E EE +A+ +V++ + ++ + + I
Sbjct: 2142 KQRKLANKMRRMINKEEKMTE--EESKLARKHSEVILDDEEEGG-------IEEEEVIPF 2192
Query: 423 RDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDIL 482
RR +K+ E ++ + + + ++E E+ EE E L +++E + + EE+
Sbjct: 2193 LKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEERE 2252
Query: 483 KQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQK 524
+++++EE + E + + +E ++E++ ++ +K
Sbjct: 2253 EEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEK 2294
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 63.5 bits (153), Expect = 8e-10
Identities = 74/403 (18%), Positives = 171/403 (42%), Gaps = 29/403 (7%)
Query: 139 LTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTEMVSSVPAENKSVLNEHQETSKQCE 198
L E KE + Q L Q ++E + +K + L E ++ ++ E
Sbjct: 292 LREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQE 351
Query: 199 QKIAIENE--WKPADIFSTLGERECDRSSL----------EAKKAQWRKELDEQVALKKK 246
QK+ + E W+ + ER ++ + E + + +K +E+ ++++
Sbjct: 352 QKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQ 411
Query: 247 EKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEELNKQI 306
E+++ ++ + W++ E + W++ ++ +Q E + K + Q + I E ++I
Sbjct: 412 EEKMQKQEENMWEQEEKE---WQQQRLPEQK------EKLWEQEKMQEQEEKIWEQEEKI 462
Query: 307 EDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSPDTQE 366
D + +EK ++ + + ++ ++ + + +++ Q + + +
Sbjct: 463 RDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEER 522
Query: 367 LADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRR 426
+ + + + E +E K ++ R + + E++ +
Sbjct: 523 MREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 582
Query: 427 RQKQLEHQKAITAQVEEKRRKKQLEEE-----QRKKEEQEEELRLAQEREEMQKQYEEDI 481
Q+Q E + ++ E+ K Q +EE + K EQEEE ++ QE+EEM + EE +
Sbjct: 583 MQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKM-QEQEEMMWEQEEKM 641
Query: 482 LKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQK 524
+Q++K K E + M+ +E Q QE+++RE +K
Sbjct: 642 QEQEEKMWEQEEKMREQEEKMREQEEKMQ--GQEEKMREQEEK 682
Score = 58.5 bits (140), Expect = 3e-08
Identities = 74/354 (20%), Positives = 160/354 (45%), Gaps = 57/354 (16%)
Query: 182 ENKSVLNEHQETSKQCEQKIAI--ENEWKPADIFSTLGERECDRSSL-EAKKAQWRKELD 238
E + + E +ET ++ E+K+ EN W+ E+E + L E K+ W +E
Sbjct: 396 EREKKMREEEETMREQEEKMQKQEENMWEQE-------EKEWQQQRLPEQKEKLWEQEKM 448
Query: 239 EQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKW 298
++ K E+E EK D + +K +W + ++ +Q + E ++ + Q+ W
Sbjct: 449 QEQEEKIWEQE--EKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEK---MRDQEQKMW 503
Query: 299 IEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYF 358
+E +D+R R+ EE++ E+ W + ++ +Q Q + T Q E
Sbjct: 504 DQEERMWEQDERLREKEERM----REQKKMWQQE-EKMREEKKTQEQ--EKKTWDQEEKM 556
Query: 359 CVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPA 418
+E + + EEE + + ++ + +K
Sbjct: 557 REEERMRE-------------REKKMREEEEMMREQEEKMQEQEEKMR------------ 591
Query: 419 QIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEE----QEEELRLAQER---- 470
+ EE+ ++++++ Q+ + EEK +++ E++ +++EE QEE+++ +E+
Sbjct: 592 EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQ 651
Query: 471 EEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQK 524
EE ++ EE + +Q++K + K E + MQ +E + +QE+++R +K
Sbjct: 652 EEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEE--KMREQEEKMRGQEEK 703
Score = 56.6 bits (135), Expect = 1e-07
Identities = 31/120 (25%), Positives = 74/120 (61%), Gaps = 9/120 (7%)
Query: 421 EERDRRRQKQL-EHQKAITAQVEEKRRKKQLEEEQRKKEEQEEEL-----RLAQEREEMQ 474
EE+ RR++K+L E +K + Q +E R +K+L E++ + +EQEE++ ++ ++ E+M
Sbjct: 275 EEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMW 334
Query: 475 KQYE---EDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRL 531
+Q E E + +++E+ M + +++ +R +E +R+++++++ E +K + R+
Sbjct: 335 RQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERI 394
Score = 54.7 bits (130), Expect = 4e-07
Identities = 31/107 (28%), Positives = 68/107 (63%), Gaps = 3/107 (2%)
Query: 421 EERDRRRQKQLEHQKAITAQVEEK--RRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYE 478
EE+ R++++L Q+ + EEK R++K+L E++++ EQE+ELR ++ E ++Q +
Sbjct: 254 EEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQ 313
Query: 479 EDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLK-QEQRIRELAQK 524
E K ++EE M + ++++ +R E ++++ QEQ++R+ ++
Sbjct: 314 EQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEER 360
Score = 53.9 bits (128), Expect = 7e-07
Identities = 90/417 (21%), Positives = 177/417 (42%), Gaps = 65/417 (15%)
Query: 122 QLQQILMTVNQGNRSLS--LTENGKEAKS-QYSLYLNSISNQPKDENIMGLFKKTEMVSS 178
+LQ+ L V+ ++ + E KE + LY N+I+N+ + L +K + S
Sbjct: 142 ELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAES 201
Query: 179 VPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELD 238
+E Q K+ ++K+ P +TL E WR+E +
Sbjct: 202 EKSEI-------QLNVKELKRKLERAKFLLPQVQTNTLQEE------------MWRQEEE 242
Query: 239 EQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKW 298
+ KK K+ + W + E + + E+ + + + +E L E Q K
Sbjct: 243 LREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKM-RRQEKRLRE----------QEKE 291
Query: 299 IEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYF 358
+ E K++ + Q+K+ E+ + +E W + + +++ Q +
Sbjct: 292 LREQEKELRE--QKKLREQEEQMQEQEEKMWEQE----EKMREQEEKMWRQEERLWEQEK 345
Query: 359 CVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPA 418
+ Q++ D Q E E+ K+ M +K M +
Sbjct: 346 QMREQEQKMRD-----------QEERMWEQDERLREKEERMREQEK------MWEQEEKM 388
Query: 419 QIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEE-EQRKKEEQEEELRLAQER----EEM 473
Q EER R R+K++ ++ + EEK +K++ EQ +KE Q++ L +E+ E+M
Sbjct: 389 QEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKM 448
Query: 474 QKQYEEDILKQKQK---EEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHD 527
Q+Q EE I +Q++K +E M + ++++ + ++ Q +QE+++R+ QK D
Sbjct: 449 QEQ-EEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWD 504
Score = 52.4 bits (124), Expect = 2e-06
Identities = 64/358 (17%), Positives = 159/358 (44%), Gaps = 31/358 (8%)
Query: 182 ENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQV 241
E + + + +E + E+++ E E K + + +E E + + KEL EQ
Sbjct: 245 EQEKKIRKQEEKMWRQEERLR-EQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQK 303
Query: 242 ALKKKEKEVSEK----WNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRK 297
L+++E+++ E+ W K E ++ +W + + L + + + + ++ + +R
Sbjct: 304 KLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQE--QKMRDQEERM 361
Query: 298 WIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEY 357
W E ++++ + +R E++ ++ + E+ + K + + Q Q +
Sbjct: 362 W--EQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQE 419
Query: 358 FCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDP 417
+ QE + P Q E E+ + ++ + +K M
Sbjct: 420 --ENMWEQEEKEWQQQRLP---EQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWG---- 470
Query: 418 AQIEERDRRRQKQLEHQKAITAQVEEKRR--KKQLEEEQRKKEEQEEELRLAQEREEMQK 475
+E+ RQ+++ Q+ + EEK R ++++ +++ + EQ+E LR +ER QK
Sbjct: 471 ---QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQK 527
Query: 476 QYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIK 533
+ + ++K +EE T + + + + +++++E+R+RE +K + +++
Sbjct: 528 KMWQQ--EEKMREEKKTQEQEK------KTWDQEEKMREEERMREREKKMREEEEMMR 577
Score = 45.8 bits (107), Expect = 2e-04
Identities = 35/175 (20%), Positives = 80/175 (45%), Gaps = 10/175 (5%)
Query: 182 ENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQV 241
E + + E +E ++ E+K+ E E K + + E+E E K + +++ EQ
Sbjct: 564 EREKKMREEEEMMREQEEKMQ-EQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE 622
Query: 242 ALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEE 301
K +++ W K E ++ +WE+ + + + E + + ++E R+ +E
Sbjct: 623 EEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMRE--QE 680
Query: 302 LNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPE 356
Q ++++ R+ EEK+ +G+E W + G + +++ Q ++ E
Sbjct: 681 EKMQGQEEKMREQEEKM---RGQEEKMWGQE----EKMWGQEEKMWGQEEMREKE 728
Score = 33.9 bits (76), Expect = 0.71
Identities = 48/277 (17%), Positives = 118/277 (42%), Gaps = 19/277 (6%)
Query: 446 RKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEE----IMTLKTNELFQT 501
+KK++ + E ++ ++ Q++E + ++ + ++ I+T + EL
Sbjct: 48 KKKKINNGTNPETTTSEGCHSPEDEKKASHQHQEALRREIEAQDHTIRILTCQKTELETA 107
Query: 502 MQRAQELAQRLKQEQ--RIRELAQKGHDTSRLIKNL--GVDTIQMEYNASN--ISNSRHD 555
+ +Q+ A++ + ++LA + H + L + + + ++ I +
Sbjct: 108 LYYSQDAARKFEDGNLGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKE 167
Query: 556 SDEISGKM--NTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCGSLMERDITNCSSPEISA 613
D +S ++ NT N KK+ +Q + L + AES + E +
Sbjct: 168 RDALSLELYRNTITNEELKKKNAELQ-EKLRL-----AESEKSEIQLNVKELKRKLERAK 221
Query: 614 ELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQTKHMKKYPKRPDWNINK 673
L+ Q T ++E+ + + L ++ + Q + R E++ + + + + + +
Sbjct: 222 FLLPQVQTNTLQEEMWRQE-EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRR 280
Query: 674 PPKRYIPASEKYPKQLQKQREEKKVRRQMELLHLVEK 710
KR ++ +Q ++ RE+KK+R Q E + E+
Sbjct: 281 QEKRLREQEKELREQEKELREQKKLREQEEQMQEQEE 317
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 63.2 bits (152), Expect = 1e-09
Identities = 99/455 (21%), Positives = 187/455 (41%), Gaps = 43/455 (9%)
Query: 74 QKEISPATPNMQKTRNTVNTSLVGKQKPH--KKHITAENMKSSLVCLTQDQLQQILMTVN 131
QK ++ A QK GK + ++ AE L + QQ L
Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713
Query: 132 QGNRSLSLTENGKEAKSQYSLYLNSI------SNQPKDENIMGLFKKTEMVSSVPAENKS 185
+ R + TE G++ + L + + Q + E L K + + A
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1773
Query: 186 VLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQVALKK 245
E + TS++ +Q++ E A F L E E R A++A+ +++L E+ A ++
Sbjct: 1774 AEEESRSTSEKSKQRLEAE-----AGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQ 1827
Query: 246 KEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEELNKQ 305
+ +E+++++ EK + ++ T L A+K++ E L +
Sbjct: 1828 R--------------AEAERVLAEKLAAIGEA--TRLKTEAEIALKEKEAEN--ERLRRL 1869
Query: 306 IEDD--RQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSPD 363
ED+ ++R++EE+ K + +R A + S Q L + ++ + +
Sbjct: 1870 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV-----E 1924
Query: 364 TQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEER 423
+ LA +S G E I +D + SK+ L + A EE
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNAEDTL--RSKEQAELEA--ARQRQLAAEEE 1980
Query: 424 DRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILK 483
RRR+ + QK++ A+ E R++K EE + + + EE R +ER E + + + +
Sbjct: 1981 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040
Query: 484 QKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRI 518
+ ++ + + F Q+ QEL Q L+QEQ +
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2075
Score = 60.5 bits (145), Expect = 7e-09
Identities = 116/633 (18%), Positives = 260/633 (41%), Gaps = 87/633 (13%)
Query: 123 LQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLF--KKTEMVSSVP 180
L+++ + + R L E + + Q +L S + + ++ F K ++ S+
Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1597
Query: 181 AENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQ 240
E+ +V +E ++ +Q+ E + A ERE +R W+ + +E
Sbjct: 1598 EEHVAVAQLREEAERRAQQQAEAERAREEA-------ERELER---------WQLKANEA 1641
Query: 241 VALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQ-ELQRKWI 299
+ L+ + +EV+++ ++E++K +K + ++R E AV+Q EL + +
Sbjct: 1642 LRLRLQAEEVAQQ--KSLAQAEAEK---QKEEAEREARRRGKAEE--QAVRQRELAEQEL 1694
Query: 300 EELNKQIEDDRQRKI--EEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEY 357
E+ + E Q+++ E+++I + E G Q + +
Sbjct: 1695 EKQRQLAEGTAQQRLAAEQELIRLRAETEQ-------------GEQQRQLLE-------- 1733
Query: 358 FCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDP 417
+ELA + T + E E + +V++A+ + T+
Sbjct: 1734 -------EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1786
Query: 418 AQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQE----REEM 473
++E R ++ E + A EE +R++QL EE ++ E E LA++ E
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846
Query: 474 QKQYEEDIL---KQKQKEEIMTLKTNELFQTMQRAQELAQ-RLKQEQRIRELAQKGHDTS 529
+ + E +I K+ + E + L +E FQ + ++ AQ + E+R+ +L +
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1906
Query: 530 RLIKNLGVDTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIG-IF 588
K L DT++ R +EI ++ + K + +L +G I
Sbjct: 1907 ERQKGLVEDTLRQR---------RQVEEEILALKASFEKAAAGKAEL-----ELELGRIR 1952
Query: 589 TNAESHCGSLMERDITNCSSPEISAELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCN 648
+NAE S + ++ +++AE + ++ +E Q A+ E+ +
Sbjct: 1953 SNAEDTLRSKEQAELEAARQRQLAAE---EERRRREAEERVQKSLAAEEEAARQRKAALE 2009
Query: 649 QFTRIEKQTKHMKKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEK--KVRRQMELLH 706
+ R++ + + ++ +R + + ++ A E K+LQ + + V+++ + L
Sbjct: 2010 EVERLKAKVEEARRLRERAE---QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2066
Query: 707 LVEKNNPGHLSQNRGISPEIFHSSHQETESKLR 739
+ L Q RG + ++ + E++++
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2099
Score = 58.2 bits (139), Expect = 4e-08
Identities = 77/391 (19%), Positives = 166/391 (42%), Gaps = 46/391 (11%)
Query: 179 VPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELD 238
V + ++SV+ E+ + + + +++ I TL E + E ++A+ R+ L
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKF-ISETLRRMEEEERLAEQQRAEERERLA 1363
Query: 239 EQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKW 298
E A +K+++++E ++E + + L Q + ++ +AV + Q++
Sbjct: 1364 EVEAALEKQRQLAEAHAQAKAQAEREA------KELQQRMQEEVVRREEAAVDAQQQKRS 1417
Query: 299 IEELNKQIEDDRQRKIEEKIIYSKGEEHDRWA---------MHFDSLKSYPGSQSQLFSQ 349
I+E +Q+ + +I+ K ++ E R + ++ + G
Sbjct: 1418 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1477
Query: 350 STHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLR 409
+ E QE A+ + +E E +A +K A +K L+
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE-LASRVKAEAEAAREKQRALQ 1536
Query: 410 SMTALLDPAQIEERDRR-RQKQLEH-----------QKAITAQVEEKRRKKQLEEEQRKK 457
++ L Q EE +RR RQ ++E Q++ A+++ KR + Q ++
Sbjct: 1537 ALEELR--LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1594
Query: 458 EEQEEELRLAQEREEMQKQYEEDILKQKQKEEI------MTLKTNELFQTMQRAQELAQR 511
QEE + +AQ REE +++ ++ ++ +EE LK NE + +A+E+AQ+
Sbjct: 1595 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1654
Query: 512 ---------LKQEQRIRELAQKGHDTSRLIK 533
++E+ RE ++G + ++
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1685
Score = 57.8 bits (138), Expect = 5e-08
Identities = 77/380 (20%), Positives = 174/380 (45%), Gaps = 50/380 (13%)
Query: 173 TEMVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQ 232
+++ + + AEN++++ ++ +++ Q+ A+ + E E R S+ A++A
Sbjct: 2241 SKLKARIEAENRALILRDKDNTQRFLQE--------EAEKMKQVAE-EAARLSVAAQEAA 2291
Query: 233 WRKELDEQVALKKK---EKEVSEKWNDPWK----KSESDKIIWEKHQILDQSRETVLLEH 285
++L E+ +++ EK + EK + K+E++ + +K +Q+R L+
Sbjct: 2292 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR---LQE 2348
Query: 286 PFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQ 345
+ Q+L + + + +E +RQR++E E +R + + S ++++
Sbjct: 2349 DKEQMAQQLAEE-TQGFQRTLEAERQRQLE------MSAEAERLKLRVAEM-SRAQARAE 2400
Query: 346 LFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKT 405
+Q KQ E ELA V T +++ + +H A+ +++ + ++
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREK 2459
Query: 406 NFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQV---------------EEKRRKKQL 450
L+ LL E + ++++ L+ +A+ +EK + +QL
Sbjct: 2460 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2519
Query: 451 ------EEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQR 504
+ +Q ++E+Q ++ ++ QER+ + EE +Q + EE + K EL Q Q+
Sbjct: 2520 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2579
Query: 505 AQELAQRLKQE-QRIRELAQ 523
++ + L +E QR+RE Q
Sbjct: 2580 RRQQEELLAEENQRLREQLQ 2599
Score = 52.8 bits (125), Expect = 1e-06
Identities = 166/907 (18%), Positives = 336/907 (37%), Gaps = 134/907 (14%)
Query: 63 KQCIDKDCLHIQKEISPATPNMQ-------KTRNTVNTSLVGKQKPHKK-HITAENMKSS 114
+Q ++++ +Q+E + AT Q K R + L K + ++ T+E K
Sbjct: 1729 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1788
Query: 115 LVCLTQDQLQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTE 174
L + + + + R +L E EAK Q L + Q +
Sbjct: 1789 L----EAEAGRFRELAEEAARLRALAE---EAKRQRQLAEEDAARQRAE----------- 1830
Query: 175 MVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGEREC-DRSSLEAKKAQW 233
V AE + + E T + E +IA++ + + L E E R LE + AQ
Sbjct: 1831 -AERVLAEKLAAIGE--ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1887
Query: 234 RKELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQE 293
+ +++E++A +K + SE ++ +K + D R+ +E A+K
Sbjct: 1888 KADIEERLAQLRKASD-----------SELER---QKGLVEDTLRQRRQVEEEILALKAS 1933
Query: 294 LQRKWIEELNKQIEDDRQRKIEEKIIYSK--------------GEEHDRWAMHFDSLKSY 339
++ + ++E R R E + SK EE R + ++
Sbjct: 1934 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1993
Query: 340 PGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEE---EHIAKPIKD 396
++ + Q E + +E + + Q++ ++E + + K
Sbjct: 1994 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2053
Query: 397 VVMANSKKTNFLRSMT----ALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEE 452
A +K L+ ++LD + E RR + + + A+ E + ++Q+EE
Sbjct: 2054 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2113
Query: 453 EQRKKEEQEEELRLAQE----REEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQR---- 504
+R K+ EE+ + + E+++K+ E++ ++ Q E+ + M++
Sbjct: 2114 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF 2173
Query: 505 -AQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDEISGKM 563
Q L Q+ + EQ + L + +T L + +++ A+ + R +E +
Sbjct: 2174 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2233
Query: 564 NTYMNSTTSKK-------DTGVQTDDLNIGIFTNAESHCGSLMERDITNCSSPEISAELI 616
M + K + D N F E+ + + S A +
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293
Query: 617 GQFSTKKNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQTKHMKKYPKRPDWNINKPPK 676
Q + +++L Q + A EK + TR++ + + +++ + + +
Sbjct: 2294 RQLA----EEDLAQQR-ALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL----AQEQAR 2344
Query: 677 RYIPASEKYPKQLQKQRE------EKKVRRQMELLHLVE--KNNPGHLSQNRGISPE--- 725
R E+ +QL ++ + E + +RQ+E+ E K +S+ + + E
Sbjct: 2345 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2404
Query: 726 IFHSSHQETESKL-RWHLVKKEEEPL----------NIHSFSKERSPSSPVPVVKNRTQQ 774
F +E KL R L +E+ L + H + R + + K + QQ
Sbjct: 2405 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2464
Query: 775 TQNTLHLPLKNSSYERENLISGSNQTELSSGISESSHFIPYVRTNE-----IYYLDPDAP 829
L L + ++ + Q S +SE + R E + L D
Sbjct: 2465 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2524
Query: 830 LSGPSTQDPQYQNSQDCGQKRQLFDSDCVRDPLLNPNMVKNRDRQQAILKGLSELRQGLL 889
++ Q + Q Q+RQ L +M + R RQ E +G+
Sbjct: 2525 AKAQQLREEQQRQQQQMEQERQ----------RLVASMEEARRRQH-------EAEEGVR 2567
Query: 890 QKQKELE 896
+KQ+EL+
Sbjct: 2568 RKQEELQ 2574
Score = 42.7 bits (99), Expect = 0.002
Identities = 65/312 (20%), Positives = 128/312 (41%), Gaps = 64/312 (20%)
Query: 191 QETSKQCEQKIAIENEWKPADIFSTLGER-----ECDRSSL---EAKKAQWRKELDEQVA 242
QE +Q Q++A E + + + + E +R L E +AQ R E D Q
Sbjct: 2347 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ-R 2405
Query: 243 LKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEEL 302
+K+ +E+ EK + ++ EK ++ +T+ ++ S E R+ I EL
Sbjct: 2406 FRKQAEEIGEKLH------RTELATQEKVTLV----QTLEIQRQQSDHDAERLREAIAEL 2455
Query: 303 NKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSP 362
++ E +Q E K++ K EE Q QL ++ Q +
Sbjct: 2456 EREKEKLQQ---EAKLLQLKSEEMQTV------------QQEQLLQETQALQQSFL---- 2496
Query: 363 DTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEE 422
SE++ + + + + +K + A Q+ E
Sbjct: 2497 ----------------------SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ--QLRE 2532
Query: 423 RDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDIL 482
+R+Q+Q+E ++ E+ R++Q E E+ + +QEE +L Q+R + ++ E+
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE-- 2590
Query: 483 KQKQKEEIMTLK 494
Q+ +E++ L+
Sbjct: 2591 NQRLREQLQLLE 2602
Score = 37.0 bits (84), Expect = 0.084
Identities = 44/171 (25%), Positives = 78/171 (45%), Gaps = 14/171 (8%)
Query: 366 ELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQ-IEERD 424
E V ++ P+ + SE E ++ V ++ L++++ ++ Q EE
Sbjct: 1046 EAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVL 1105
Query: 425 RRRQKQLEHQKAITAQVEE--------KRRKKQLEEEQRKKEEQEEELRLAQEREE--MQ 474
R ++QL+ +A+ A + E K+ + Q E +Q + +ELR AQE E Q
Sbjct: 1106 RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQ 1165
Query: 475 KQYEEDILKQKQKEEIMTLKTN---ELFQTMQRAQELAQRLKQEQRIRELA 522
+ E D+ ++ +E + L L QT R +EL Q +Q + RE A
Sbjct: 1166 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1216
Score = 33.1 bits (74), Expect = 1.2
Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 31/137 (22%)
Query: 425 RRRQKQLEHQKAITAQ-VEEKRRKKQ--LEEEQRKKEEQEEELRLAQEREEMQKQYEEDI 481
RRRQ+Q++ +Q V E+ R++Q LEE +R E+ EE R A++ K YE +
Sbjct: 1227 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL 1286
Query: 482 LKQKQK---------------------EEIMTLKTNELFQTMQRAQ------ELAQRLKQ 514
+ K + +E + L+T+ T +Q E +R+++
Sbjct: 1287 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1346
Query: 515 EQRIRELAQKGHDTSRL 531
E+R+ E Q+ + RL
Sbjct: 1347 EERLAE-QQRAEERERL 1362
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 63.2 bits (152), Expect = 1e-09
Identities = 99/455 (21%), Positives = 187/455 (41%), Gaps = 43/455 (9%)
Query: 74 QKEISPATPNMQKTRNTVNTSLVGKQKPH--KKHITAENMKSSLVCLTQDQLQQILMTVN 131
QK ++ A QK GK + ++ AE L + QQ L
Sbjct: 1658 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1717
Query: 132 QGNRSLSLTENGKEAKSQYSLYLNSI------SNQPKDENIMGLFKKTEMVSSVPAENKS 185
+ R + TE G++ + L + + Q + E L K + + A
Sbjct: 1718 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1777
Query: 186 VLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQVALKK 245
E + TS++ +Q++ E A F L E E R A++A+ +++L E+ A ++
Sbjct: 1778 AEEESRSTSEKSKQRLEAE-----AGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQ 1831
Query: 246 KEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEELNKQ 305
+ +E+++++ EK + ++ T L A+K++ E L +
Sbjct: 1832 R--------------AEAERVLAEKLAAIGEA--TRLKTEAEIALKEKEAEN--ERLRRL 1873
Query: 306 IEDD--RQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSPD 363
ED+ ++R++EE+ K + +R A + S Q L + ++ + +
Sbjct: 1874 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV-----E 1928
Query: 364 TQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEER 423
+ LA +S G E I +D + SK+ L + A EE
Sbjct: 1929 EEILALKASFEKAAAGKAELELELGRIRSNAEDTL--RSKEQAELEA--ARQRQLAAEEE 1984
Query: 424 DRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILK 483
RRR+ + QK++ A+ E R++K EE + + + EE R +ER E + + + +
Sbjct: 1985 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2044
Query: 484 QKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRI 518
+ ++ + + F Q+ QEL Q L+QEQ +
Sbjct: 2045 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2079
Score = 60.5 bits (145), Expect = 7e-09
Identities = 116/633 (18%), Positives = 260/633 (41%), Gaps = 87/633 (13%)
Query: 123 LQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLF--KKTEMVSSVP 180
L+++ + + R L E + + Q +L S + + ++ F K ++ S+
Sbjct: 1542 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1601
Query: 181 AENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQ 240
E+ +V +E ++ +Q+ E + A ERE +R W+ + +E
Sbjct: 1602 EEHVAVAQLREEAERRAQQQAEAERAREEA-------ERELER---------WQLKANEA 1645
Query: 241 VALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQ-ELQRKWI 299
+ L+ + +EV+++ ++E++K +K + ++R E AV+Q EL + +
Sbjct: 1646 LRLRLQAEEVAQQ--KSLAQAEAEK---QKEEAEREARRRGKAEE--QAVRQRELAEQEL 1698
Query: 300 EELNKQIEDDRQRKI--EEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEY 357
E+ + E Q+++ E+++I + E G Q + +
Sbjct: 1699 EKQRQLAEGTAQQRLAAEQELIRLRAETEQ-------------GEQQRQLLE-------- 1737
Query: 358 FCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDP 417
+ELA + T + E E + +V++A+ + T+
Sbjct: 1738 -------EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1790
Query: 418 AQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQE----REEM 473
++E R ++ E + A EE +R++QL EE ++ E E LA++ E
Sbjct: 1791 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1850
Query: 474 QKQYEEDIL---KQKQKEEIMTLKTNELFQTMQRAQELAQ-RLKQEQRIRELAQKGHDTS 529
+ + E +I K+ + E + L +E FQ + ++ AQ + E+R+ +L +
Sbjct: 1851 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1910
Query: 530 RLIKNLGVDTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIG-IF 588
K L DT++ R +EI ++ + K + +L +G I
Sbjct: 1911 ERQKGLVEDTLRQR---------RQVEEEILALKASFEKAAAGKAEL-----ELELGRIR 1956
Query: 589 TNAESHCGSLMERDITNCSSPEISAELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCN 648
+NAE S + ++ +++AE + ++ +E Q A+ E+ +
Sbjct: 1957 SNAEDTLRSKEQAELEAARQRQLAAE---EERRRREAEERVQKSLAAEEEAARQRKAALE 2013
Query: 649 QFTRIEKQTKHMKKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEK--KVRRQMELLH 706
+ R++ + + ++ +R + + ++ A E K+LQ + + V+++ + L
Sbjct: 2014 EVERLKAKVEEARRLRERAE---QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2070
Query: 707 LVEKNNPGHLSQNRGISPEIFHSSHQETESKLR 739
+ L Q RG + ++ + E++++
Sbjct: 2071 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2103
Score = 58.2 bits (139), Expect = 4e-08
Identities = 77/391 (19%), Positives = 166/391 (42%), Gaps = 46/391 (11%)
Query: 179 VPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELD 238
V + ++SV+ E+ + + + +++ I TL E + E ++A+ R+ L
Sbjct: 1309 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKF-ISETLRRMEEEERLAEQQRAEERERLA 1367
Query: 239 EQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKW 298
E A +K+++++E ++E + + L Q + ++ +AV + Q++
Sbjct: 1368 EVEAALEKQRQLAEAHAQAKAQAEREA------KELQQRMQEEVVRREEAAVDAQQQKRS 1421
Query: 299 IEELNKQIEDDRQRKIEEKIIYSKGEEHDRWA---------MHFDSLKSYPGSQSQLFSQ 349
I+E +Q+ + +I+ K ++ E R + ++ + G
Sbjct: 1422 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1481
Query: 350 STHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLR 409
+ E QE A+ + +E E +A +K A +K L+
Sbjct: 1482 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE-LASRVKAEAEAAREKQRALQ 1540
Query: 410 SMTALLDPAQIEERDRR-RQKQLEH-----------QKAITAQVEEKRRKKQLEEEQRKK 457
++ L Q EE +RR RQ ++E Q++ A+++ KR + Q ++
Sbjct: 1541 ALEELR--LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1598
Query: 458 EEQEEELRLAQEREEMQKQYEEDILKQKQKEEI------MTLKTNELFQTMQRAQELAQR 511
QEE + +AQ REE +++ ++ ++ +EE LK NE + +A+E+AQ+
Sbjct: 1599 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1658
Query: 512 ---------LKQEQRIRELAQKGHDTSRLIK 533
++E+ RE ++G + ++
Sbjct: 1659 KSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1689
Score = 57.8 bits (138), Expect = 5e-08
Identities = 77/380 (20%), Positives = 174/380 (45%), Gaps = 50/380 (13%)
Query: 173 TEMVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQ 232
+++ + + AEN++++ ++ +++ Q+ A+ + E E R S+ A++A
Sbjct: 2245 SKLKARIEAENRALILRDKDNTQRFLQE--------EAEKMKQVAE-EAARLSVAAQEAA 2295
Query: 233 WRKELDEQVALKKK---EKEVSEKWNDPWK----KSESDKIIWEKHQILDQSRETVLLEH 285
++L E+ +++ EK + EK + K+E++ + +K +Q+R L+
Sbjct: 2296 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR---LQE 2352
Query: 286 PFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQ 345
+ Q+L + + + +E +RQR++E E +R + + S ++++
Sbjct: 2353 DKEQMAQQLAEE-TQGFQRTLEAERQRQLE------MSAEAERLKLRVAEM-SRAQARAE 2404
Query: 346 LFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKT 405
+Q KQ E ELA V T +++ + +H A+ +++ + ++
Sbjct: 2405 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREK 2463
Query: 406 NFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQV---------------EEKRRKKQL 450
L+ LL E + ++++ L+ +A+ +EK + +QL
Sbjct: 2464 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2523
Query: 451 ------EEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQR 504
+ +Q ++E+Q ++ ++ QER+ + EE +Q + EE + K EL Q Q+
Sbjct: 2524 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2583
Query: 505 AQELAQRLKQE-QRIRELAQ 523
++ + L +E QR+RE Q
Sbjct: 2584 RRQQEELLAEENQRLREQLQ 2603
Score = 52.8 bits (125), Expect = 1e-06
Identities = 166/907 (18%), Positives = 336/907 (37%), Gaps = 134/907 (14%)
Query: 63 KQCIDKDCLHIQKEISPATPNMQ-------KTRNTVNTSLVGKQKPHKK-HITAENMKSS 114
+Q ++++ +Q+E + AT Q K R + L K + ++ T+E K
Sbjct: 1733 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1792
Query: 115 LVCLTQDQLQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTE 174
L + + + + R +L E EAK Q L + Q +
Sbjct: 1793 L----EAEAGRFRELAEEAARLRALAE---EAKRQRQLAEEDAARQRAE----------- 1834
Query: 175 MVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGEREC-DRSSLEAKKAQW 233
V AE + + E T + E +IA++ + + L E E R LE + AQ
Sbjct: 1835 -AERVLAEKLAAIGE--ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1891
Query: 234 RKELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQE 293
+ +++E++A +K + SE ++ +K + D R+ +E A+K
Sbjct: 1892 KADIEERLAQLRKASD-----------SELER---QKGLVEDTLRQRRQVEEEILALKAS 1937
Query: 294 LQRKWIEELNKQIEDDRQRKIEEKIIYSK--------------GEEHDRWAMHFDSLKSY 339
++ + ++E R R E + SK EE R + ++
Sbjct: 1938 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1997
Query: 340 PGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEE---EHIAKPIKD 396
++ + Q E + +E + + Q++ ++E + + K
Sbjct: 1998 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2057
Query: 397 VVMANSKKTNFLRSMT----ALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEE 452
A +K L+ ++LD + E RR + + + A+ E + ++Q+EE
Sbjct: 2058 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2117
Query: 453 EQRKKEEQEEELRLAQE----REEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQR---- 504
+R K+ EE+ + + E+++K+ E++ ++ Q E+ + M++
Sbjct: 2118 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF 2177
Query: 505 -AQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDEISGKM 563
Q L Q+ + EQ + L + +T L + +++ A+ + R +E +
Sbjct: 2178 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2237
Query: 564 NTYMNSTTSKK-------DTGVQTDDLNIGIFTNAESHCGSLMERDITNCSSPEISAELI 616
M + K + D N F E+ + + S A +
Sbjct: 2238 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2297
Query: 617 GQFSTKKNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQTKHMKKYPKRPDWNINKPPK 676
Q + +++L Q + A EK + TR++ + + +++ + + +
Sbjct: 2298 RQLA----EEDLAQQR-ALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL----AQEQAR 2348
Query: 677 RYIPASEKYPKQLQKQRE------EKKVRRQMELLHLVE--KNNPGHLSQNRGISPE--- 725
R E+ +QL ++ + E + +RQ+E+ E K +S+ + + E
Sbjct: 2349 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2408
Query: 726 IFHSSHQETESKL-RWHLVKKEEEPL----------NIHSFSKERSPSSPVPVVKNRTQQ 774
F +E KL R L +E+ L + H + R + + K + QQ
Sbjct: 2409 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2468
Query: 775 TQNTLHLPLKNSSYERENLISGSNQTELSSGISESSHFIPYVRTNE-----IYYLDPDAP 829
L L + ++ + Q S +SE + R E + L D
Sbjct: 2469 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2528
Query: 830 LSGPSTQDPQYQNSQDCGQKRQLFDSDCVRDPLLNPNMVKNRDRQQAILKGLSELRQGLL 889
++ Q + Q Q+RQ L +M + R RQ E +G+
Sbjct: 2529 AKAQQLREEQQRQQQQMEQERQ----------RLVASMEEARRRQH-------EAEEGVR 2571
Query: 890 QKQKELE 896
+KQ+EL+
Sbjct: 2572 RKQEELQ 2578
Score = 42.7 bits (99), Expect = 0.002
Identities = 65/312 (20%), Positives = 128/312 (41%), Gaps = 64/312 (20%)
Query: 191 QETSKQCEQKIAIENEWKPADIFSTLGER-----ECDRSSL---EAKKAQWRKELDEQVA 242
QE +Q Q++A E + + + + E +R L E +AQ R E D Q
Sbjct: 2351 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ-R 2409
Query: 243 LKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEEL 302
+K+ +E+ EK + ++ EK ++ +T+ ++ S E R+ I EL
Sbjct: 2410 FRKQAEEIGEKLH------RTELATQEKVTLV----QTLEIQRQQSDHDAERLREAIAEL 2459
Query: 303 NKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSP 362
++ E +Q E K++ K EE Q QL ++ Q +
Sbjct: 2460 EREKEKLQQ---EAKLLQLKSEEMQTV------------QQEQLLQETQALQQSFL---- 2500
Query: 363 DTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEE 422
SE++ + + + + +K + A Q+ E
Sbjct: 2501 ----------------------SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ--QLRE 2536
Query: 423 RDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDIL 482
+R+Q+Q+E ++ E+ R++Q E E+ + +QEE +L Q+R + ++ E+
Sbjct: 2537 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE-- 2594
Query: 483 KQKQKEEIMTLK 494
Q+ +E++ L+
Sbjct: 2595 NQRLREQLQLLE 2606
Score = 37.0 bits (84), Expect = 0.084
Identities = 44/171 (25%), Positives = 78/171 (45%), Gaps = 14/171 (8%)
Query: 366 ELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQ-IEERD 424
E V ++ P+ + SE E ++ V ++ L++++ ++ Q EE
Sbjct: 1050 EAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVL 1109
Query: 425 RRRQKQLEHQKAITAQVEE--------KRRKKQLEEEQRKKEEQEEELRLAQEREE--MQ 474
R ++QL+ +A+ A + E K+ + Q E +Q + +ELR AQE E Q
Sbjct: 1110 RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQ 1169
Query: 475 KQYEEDILKQKQKEEIMTLKTN---ELFQTMQRAQELAQRLKQEQRIRELA 522
+ E D+ ++ +E + L L QT R +EL Q +Q + RE A
Sbjct: 1170 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1220
Score = 33.1 bits (74), Expect = 1.2
Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 31/137 (22%)
Query: 425 RRRQKQLEHQKAITAQ-VEEKRRKKQ--LEEEQRKKEEQEEELRLAQEREEMQKQYEEDI 481
RRRQ+Q++ +Q V E+ R++Q LEE +R E+ EE R A++ K YE +
Sbjct: 1231 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL 1290
Query: 482 LKQKQK---------------------EEIMTLKTNELFQTMQRAQ------ELAQRLKQ 514
+ K + +E + L+T+ T +Q E +R+++
Sbjct: 1291 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1350
Query: 515 EQRIRELAQKGHDTSRL 531
E+R+ E Q+ + RL
Sbjct: 1351 EERLAE-QQRAEERERL 1366
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 63.2 bits (152), Expect = 1e-09
Identities = 99/455 (21%), Positives = 187/455 (41%), Gaps = 43/455 (9%)
Query: 74 QKEISPATPNMQKTRNTVNTSLVGKQKPH--KKHITAENMKSSLVCLTQDQLQQILMTVN 131
QK ++ A QK GK + ++ AE L + QQ L
Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713
Query: 132 QGNRSLSLTENGKEAKSQYSLYLNSI------SNQPKDENIMGLFKKTEMVSSVPAENKS 185
+ R + TE G++ + L + + Q + E L K + + A
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1773
Query: 186 VLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQVALKK 245
E + TS++ +Q++ E A F L E E R A++A+ +++L E+ A ++
Sbjct: 1774 AEEESRSTSEKSKQRLEAE-----AGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQ 1827
Query: 246 KEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEELNKQ 305
+ +E+++++ EK + ++ T L A+K++ E L +
Sbjct: 1828 R--------------AEAERVLAEKLAAIGEA--TRLKTEAEIALKEKEAEN--ERLRRL 1869
Query: 306 IEDD--RQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSPD 363
ED+ ++R++EE+ K + +R A + S Q L + ++ + +
Sbjct: 1870 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV-----E 1924
Query: 364 TQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEER 423
+ LA +S G E I +D + SK+ L + A EE
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNAEDTL--RSKEQAELEA--ARQRQLAAEEE 1980
Query: 424 DRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILK 483
RRR+ + QK++ A+ E R++K EE + + + EE R +ER E + + + +
Sbjct: 1981 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040
Query: 484 QKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRI 518
+ ++ + + F Q+ QEL Q L+QEQ +
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2075
Score = 60.5 bits (145), Expect = 7e-09
Identities = 116/633 (18%), Positives = 260/633 (41%), Gaps = 87/633 (13%)
Query: 123 LQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLF--KKTEMVSSVP 180
L+++ + + R L E + + Q +L S + + ++ F K ++ S+
Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1597
Query: 181 AENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQ 240
E+ +V +E ++ +Q+ E + A ERE +R W+ + +E
Sbjct: 1598 EEHVAVAQLREEAERRAQQQAEAERAREEA-------ERELER---------WQLKANEA 1641
Query: 241 VALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQ-ELQRKWI 299
+ L+ + +EV+++ ++E++K +K + ++R E AV+Q EL + +
Sbjct: 1642 LRLRLQAEEVAQQ--KSLAQAEAEK---QKEEAEREARRRGKAEE--QAVRQRELAEQEL 1694
Query: 300 EELNKQIEDDRQRKI--EEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEY 357
E+ + E Q+++ E+++I + E G Q + +
Sbjct: 1695 EKQRQLAEGTAQQRLAAEQELIRLRAETEQ-------------GEQQRQLLE-------- 1733
Query: 358 FCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDP 417
+ELA + T + E E + +V++A+ + T+
Sbjct: 1734 -------EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1786
Query: 418 AQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQE----REEM 473
++E R ++ E + A EE +R++QL EE ++ E E LA++ E
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846
Query: 474 QKQYEEDIL---KQKQKEEIMTLKTNELFQTMQRAQELAQ-RLKQEQRIRELAQKGHDTS 529
+ + E +I K+ + E + L +E FQ + ++ AQ + E+R+ +L +
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1906
Query: 530 RLIKNLGVDTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIG-IF 588
K L DT++ R +EI ++ + K + +L +G I
Sbjct: 1907 ERQKGLVEDTLRQR---------RQVEEEILALKASFEKAAAGKAEL-----ELELGRIR 1952
Query: 589 TNAESHCGSLMERDITNCSSPEISAELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCN 648
+NAE S + ++ +++AE + ++ +E Q A+ E+ +
Sbjct: 1953 SNAEDTLRSKEQAELEAARQRQLAAE---EERRRREAEERVQKSLAAEEEAARQRKAALE 2009
Query: 649 QFTRIEKQTKHMKKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEK--KVRRQMELLH 706
+ R++ + + ++ +R + + ++ A E K+LQ + + V+++ + L
Sbjct: 2010 EVERLKAKVEEARRLRERAE---QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2066
Query: 707 LVEKNNPGHLSQNRGISPEIFHSSHQETESKLR 739
+ L Q RG + ++ + E++++
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2099
Score = 58.2 bits (139), Expect = 4e-08
Identities = 77/391 (19%), Positives = 166/391 (42%), Gaps = 46/391 (11%)
Query: 179 VPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELD 238
V + ++SV+ E+ + + + +++ I TL E + E ++A+ R+ L
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKF-ISETLRRMEEEERLAEQQRAEERERLA 1363
Query: 239 EQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKW 298
E A +K+++++E ++E + + L Q + ++ +AV + Q++
Sbjct: 1364 EVEAALEKQRQLAEAHAQAKAQAEREA------KELQQRMQEEVVRREEAAVDAQQQKRS 1417
Query: 299 IEELNKQIEDDRQRKIEEKIIYSKGEEHDRWA---------MHFDSLKSYPGSQSQLFSQ 349
I+E +Q+ + +I+ K ++ E R + ++ + G
Sbjct: 1418 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1477
Query: 350 STHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLR 409
+ E QE A+ + +E E +A +K A +K L+
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE-LASRVKAEAEAAREKQRALQ 1536
Query: 410 SMTALLDPAQIEERDRR-RQKQLEH-----------QKAITAQVEEKRRKKQLEEEQRKK 457
++ L Q EE +RR RQ ++E Q++ A+++ KR + Q ++
Sbjct: 1537 ALEELR--LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1594
Query: 458 EEQEEELRLAQEREEMQKQYEEDILKQKQKEEI------MTLKTNELFQTMQRAQELAQR 511
QEE + +AQ REE +++ ++ ++ +EE LK NE + +A+E+AQ+
Sbjct: 1595 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1654
Query: 512 ---------LKQEQRIRELAQKGHDTSRLIK 533
++E+ RE ++G + ++
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1685
Score = 57.8 bits (138), Expect = 5e-08
Identities = 77/380 (20%), Positives = 174/380 (45%), Gaps = 50/380 (13%)
Query: 173 TEMVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQ 232
+++ + + AEN++++ ++ +++ Q+ A+ + E E R S+ A++A
Sbjct: 2241 SKLKARIEAENRALILRDKDNTQRFLQE--------EAEKMKQVAE-EAARLSVAAQEAA 2291
Query: 233 WRKELDEQVALKKK---EKEVSEKWNDPWK----KSESDKIIWEKHQILDQSRETVLLEH 285
++L E+ +++ EK + EK + K+E++ + +K +Q+R L+
Sbjct: 2292 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR---LQE 2348
Query: 286 PFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQ 345
+ Q+L + + + +E +RQR++E E +R + + S ++++
Sbjct: 2349 DKEQMAQQLAEE-TQGFQRTLEAERQRQLE------MSAEAERLKLRVAEM-SRAQARAE 2400
Query: 346 LFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKT 405
+Q KQ E ELA V T +++ + +H A+ +++ + ++
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREK 2459
Query: 406 NFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQV---------------EEKRRKKQL 450
L+ LL E + ++++ L+ +A+ +EK + +QL
Sbjct: 2460 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2519
Query: 451 ------EEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQR 504
+ +Q ++E+Q ++ ++ QER+ + EE +Q + EE + K EL Q Q+
Sbjct: 2520 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2579
Query: 505 AQELAQRLKQE-QRIRELAQ 523
++ + L +E QR+RE Q
Sbjct: 2580 RRQQEELLAEENQRLREQLQ 2599
Score = 52.8 bits (125), Expect = 1e-06
Identities = 166/907 (18%), Positives = 336/907 (37%), Gaps = 134/907 (14%)
Query: 63 KQCIDKDCLHIQKEISPATPNMQ-------KTRNTVNTSLVGKQKPHKK-HITAENMKSS 114
+Q ++++ +Q+E + AT Q K R + L K + ++ T+E K
Sbjct: 1729 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1788
Query: 115 LVCLTQDQLQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTE 174
L + + + + R +L E EAK Q L + Q +
Sbjct: 1789 L----EAEAGRFRELAEEAARLRALAE---EAKRQRQLAEEDAARQRAE----------- 1830
Query: 175 MVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGEREC-DRSSLEAKKAQW 233
V AE + + E T + E +IA++ + + L E E R LE + AQ
Sbjct: 1831 -AERVLAEKLAAIGE--ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1887
Query: 234 RKELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQE 293
+ +++E++A +K + SE ++ +K + D R+ +E A+K
Sbjct: 1888 KADIEERLAQLRKASD-----------SELER---QKGLVEDTLRQRRQVEEEILALKAS 1933
Query: 294 LQRKWIEELNKQIEDDRQRKIEEKIIYSK--------------GEEHDRWAMHFDSLKSY 339
++ + ++E R R E + SK EE R + ++
Sbjct: 1934 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1993
Query: 340 PGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEE---EHIAKPIKD 396
++ + Q E + +E + + Q++ ++E + + K
Sbjct: 1994 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2053
Query: 397 VVMANSKKTNFLRSMT----ALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEE 452
A +K L+ ++LD + E RR + + + A+ E + ++Q+EE
Sbjct: 2054 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2113
Query: 453 EQRKKEEQEEELRLAQE----REEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQR---- 504
+R K+ EE+ + + E+++K+ E++ ++ Q E+ + M++
Sbjct: 2114 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF 2173
Query: 505 -AQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDEISGKM 563
Q L Q+ + EQ + L + +T L + +++ A+ + R +E +
Sbjct: 2174 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2233
Query: 564 NTYMNSTTSKK-------DTGVQTDDLNIGIFTNAESHCGSLMERDITNCSSPEISAELI 616
M + K + D N F E+ + + S A +
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293
Query: 617 GQFSTKKNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQTKHMKKYPKRPDWNINKPPK 676
Q + +++L Q + A EK + TR++ + + +++ + + +
Sbjct: 2294 RQLA----EEDLAQQR-ALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL----AQEQAR 2344
Query: 677 RYIPASEKYPKQLQKQRE------EKKVRRQMELLHLVE--KNNPGHLSQNRGISPE--- 725
R E+ +QL ++ + E + +RQ+E+ E K +S+ + + E
Sbjct: 2345 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2404
Query: 726 IFHSSHQETESKL-RWHLVKKEEEPL----------NIHSFSKERSPSSPVPVVKNRTQQ 774
F +E KL R L +E+ L + H + R + + K + QQ
Sbjct: 2405 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2464
Query: 775 TQNTLHLPLKNSSYERENLISGSNQTELSSGISESSHFIPYVRTNE-----IYYLDPDAP 829
L L + ++ + Q S +SE + R E + L D
Sbjct: 2465 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2524
Query: 830 LSGPSTQDPQYQNSQDCGQKRQLFDSDCVRDPLLNPNMVKNRDRQQAILKGLSELRQGLL 889
++ Q + Q Q+RQ L +M + R RQ E +G+
Sbjct: 2525 AKAQQLREEQQRQQQQMEQERQ----------RLVASMEEARRRQH-------EAEEGVR 2567
Query: 890 QKQKELE 896
+KQ+EL+
Sbjct: 2568 RKQEELQ 2574
Score = 42.7 bits (99), Expect = 0.002
Identities = 65/312 (20%), Positives = 128/312 (41%), Gaps = 64/312 (20%)
Query: 191 QETSKQCEQKIAIENEWKPADIFSTLGER-----ECDRSSL---EAKKAQWRKELDEQVA 242
QE +Q Q++A E + + + + E +R L E +AQ R E D Q
Sbjct: 2347 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ-R 2405
Query: 243 LKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEEL 302
+K+ +E+ EK + ++ EK ++ +T+ ++ S E R+ I EL
Sbjct: 2406 FRKQAEEIGEKLH------RTELATQEKVTLV----QTLEIQRQQSDHDAERLREAIAEL 2455
Query: 303 NKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSP 362
++ E +Q E K++ K EE Q QL ++ Q +
Sbjct: 2456 EREKEKLQQ---EAKLLQLKSEEMQTV------------QQEQLLQETQALQQSFL---- 2496
Query: 363 DTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEE 422
SE++ + + + + +K + A Q+ E
Sbjct: 2497 ----------------------SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ--QLRE 2532
Query: 423 RDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDIL 482
+R+Q+Q+E ++ E+ R++Q E E+ + +QEE +L Q+R + ++ E+
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE-- 2590
Query: 483 KQKQKEEIMTLK 494
Q+ +E++ L+
Sbjct: 2591 NQRLREQLQLLE 2602
Score = 37.0 bits (84), Expect = 0.084
Identities = 44/171 (25%), Positives = 78/171 (45%), Gaps = 14/171 (8%)
Query: 366 ELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQ-IEERD 424
E V ++ P+ + SE E ++ V ++ L++++ ++ Q EE
Sbjct: 1046 EAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVL 1105
Query: 425 RRRQKQLEHQKAITAQVEE--------KRRKKQLEEEQRKKEEQEEELRLAQEREE--MQ 474
R ++QL+ +A+ A + E K+ + Q E +Q + +ELR AQE E Q
Sbjct: 1106 RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQ 1165
Query: 475 KQYEEDILKQKQKEEIMTLKTN---ELFQTMQRAQELAQRLKQEQRIRELA 522
+ E D+ ++ +E + L L QT R +EL Q +Q + RE A
Sbjct: 1166 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1216
Score = 33.1 bits (74), Expect = 1.2
Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 31/137 (22%)
Query: 425 RRRQKQLEHQKAITAQ-VEEKRRKKQ--LEEEQRKKEEQEEELRLAQEREEMQKQYEEDI 481
RRRQ+Q++ +Q V E+ R++Q LEE +R E+ EE R A++ K YE +
Sbjct: 1227 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL 1286
Query: 482 LKQKQK---------------------EEIMTLKTNELFQTMQRAQ------ELAQRLKQ 514
+ K + +E + L+T+ T +Q E +R+++
Sbjct: 1287 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1346
Query: 515 EQRIRELAQKGHDTSRL 531
E+R+ E Q+ + RL
Sbjct: 1347 EERLAE-QQRAEERERL 1362
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 63.2 bits (152), Expect = 1e-09
Identities = 99/455 (21%), Positives = 187/455 (41%), Gaps = 43/455 (9%)
Query: 74 QKEISPATPNMQKTRNTVNTSLVGKQKPH--KKHITAENMKSSLVCLTQDQLQQILMTVN 131
QK ++ A QK GK + ++ AE L + QQ L
Sbjct: 1622 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1681
Query: 132 QGNRSLSLTENGKEAKSQYSLYLNSI------SNQPKDENIMGLFKKTEMVSSVPAENKS 185
+ R + TE G++ + L + + Q + E L K + + A
Sbjct: 1682 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1741
Query: 186 VLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQVALKK 245
E + TS++ +Q++ E A F L E E R A++A+ +++L E+ A ++
Sbjct: 1742 AEEESRSTSEKSKQRLEAE-----AGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQ 1795
Query: 246 KEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEELNKQ 305
+ +E+++++ EK + ++ T L A+K++ E L +
Sbjct: 1796 R--------------AEAERVLAEKLAAIGEA--TRLKTEAEIALKEKEAEN--ERLRRL 1837
Query: 306 IEDD--RQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSPD 363
ED+ ++R++EE+ K + +R A + S Q L + ++ + +
Sbjct: 1838 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV-----E 1892
Query: 364 TQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEER 423
+ LA +S G E I +D + SK+ L + A EE
Sbjct: 1893 EEILALKASFEKAAAGKAELELELGRIRSNAEDTL--RSKEQAELEA--ARQRQLAAEEE 1948
Query: 424 DRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILK 483
RRR+ + QK++ A+ E R++K EE + + + EE R +ER E + + + +
Sbjct: 1949 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2008
Query: 484 QKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRI 518
+ ++ + + F Q+ QEL Q L+QEQ +
Sbjct: 2009 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2043
Score = 60.5 bits (145), Expect = 7e-09
Identities = 116/633 (18%), Positives = 260/633 (41%), Gaps = 87/633 (13%)
Query: 123 LQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLF--KKTEMVSSVP 180
L+++ + + R L E + + Q +L S + + ++ F K ++ S+
Sbjct: 1506 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1565
Query: 181 AENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQ 240
E+ +V +E ++ +Q+ E + A ERE +R W+ + +E
Sbjct: 1566 EEHVAVAQLREEAERRAQQQAEAERAREEA-------ERELER---------WQLKANEA 1609
Query: 241 VALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQ-ELQRKWI 299
+ L+ + +EV+++ ++E++K +K + ++R E AV+Q EL + +
Sbjct: 1610 LRLRLQAEEVAQQ--KSLAQAEAEK---QKEEAEREARRRGKAEE--QAVRQRELAEQEL 1662
Query: 300 EELNKQIEDDRQRKI--EEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEY 357
E+ + E Q+++ E+++I + E G Q + +
Sbjct: 1663 EKQRQLAEGTAQQRLAAEQELIRLRAETEQ-------------GEQQRQLLE-------- 1701
Query: 358 FCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDP 417
+ELA + T + E E + +V++A+ + T+
Sbjct: 1702 -------EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1754
Query: 418 AQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQE----REEM 473
++E R ++ E + A EE +R++QL EE ++ E E LA++ E
Sbjct: 1755 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1814
Query: 474 QKQYEEDIL---KQKQKEEIMTLKTNELFQTMQRAQELAQ-RLKQEQRIRELAQKGHDTS 529
+ + E +I K+ + E + L +E FQ + ++ AQ + E+R+ +L +
Sbjct: 1815 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1874
Query: 530 RLIKNLGVDTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIG-IF 588
K L DT++ R +EI ++ + K + +L +G I
Sbjct: 1875 ERQKGLVEDTLRQR---------RQVEEEILALKASFEKAAAGKAEL-----ELELGRIR 1920
Query: 589 TNAESHCGSLMERDITNCSSPEISAELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCN 648
+NAE S + ++ +++AE + ++ +E Q A+ E+ +
Sbjct: 1921 SNAEDTLRSKEQAELEAARQRQLAAE---EERRRREAEERVQKSLAAEEEAARQRKAALE 1977
Query: 649 QFTRIEKQTKHMKKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEK--KVRRQMELLH 706
+ R++ + + ++ +R + + ++ A E K+LQ + + V+++ + L
Sbjct: 1978 EVERLKAKVEEARRLRERAE---QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2034
Query: 707 LVEKNNPGHLSQNRGISPEIFHSSHQETESKLR 739
+ L Q RG + ++ + E++++
Sbjct: 2035 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2067
Score = 58.2 bits (139), Expect = 4e-08
Identities = 77/391 (19%), Positives = 166/391 (42%), Gaps = 46/391 (11%)
Query: 179 VPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELD 238
V + ++SV+ E+ + + + +++ I TL E + E ++A+ R+ L
Sbjct: 1273 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKF-ISETLRRMEEEERLAEQQRAEERERLA 1331
Query: 239 EQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKW 298
E A +K+++++E ++E + + L Q + ++ +AV + Q++
Sbjct: 1332 EVEAALEKQRQLAEAHAQAKAQAEREA------KELQQRMQEEVVRREEAAVDAQQQKRS 1385
Query: 299 IEELNKQIEDDRQRKIEEKIIYSKGEEHDRWA---------MHFDSLKSYPGSQSQLFSQ 349
I+E +Q+ + +I+ K ++ E R + ++ + G
Sbjct: 1386 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1445
Query: 350 STHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLR 409
+ E QE A+ + +E E +A +K A +K L+
Sbjct: 1446 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE-LASRVKAEAEAAREKQRALQ 1504
Query: 410 SMTALLDPAQIEERDRR-RQKQLEH-----------QKAITAQVEEKRRKKQLEEEQRKK 457
++ L Q EE +RR RQ ++E Q++ A+++ KR + Q ++
Sbjct: 1505 ALEELR--LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1562
Query: 458 EEQEEELRLAQEREEMQKQYEEDILKQKQKEEI------MTLKTNELFQTMQRAQELAQR 511
QEE + +AQ REE +++ ++ ++ +EE LK NE + +A+E+AQ+
Sbjct: 1563 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1622
Query: 512 ---------LKQEQRIRELAQKGHDTSRLIK 533
++E+ RE ++G + ++
Sbjct: 1623 KSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1653
Score = 57.8 bits (138), Expect = 5e-08
Identities = 77/380 (20%), Positives = 174/380 (45%), Gaps = 50/380 (13%)
Query: 173 TEMVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQ 232
+++ + + AEN++++ ++ +++ Q+ A+ + E E R S+ A++A
Sbjct: 2209 SKLKARIEAENRALILRDKDNTQRFLQE--------EAEKMKQVAE-EAARLSVAAQEAA 2259
Query: 233 WRKELDEQVALKKK---EKEVSEKWNDPWK----KSESDKIIWEKHQILDQSRETVLLEH 285
++L E+ +++ EK + EK + K+E++ + +K +Q+R L+
Sbjct: 2260 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR---LQE 2316
Query: 286 PFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQ 345
+ Q+L + + + +E +RQR++E E +R + + S ++++
Sbjct: 2317 DKEQMAQQLAEE-TQGFQRTLEAERQRQLE------MSAEAERLKLRVAEM-SRAQARAE 2368
Query: 346 LFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKT 405
+Q KQ E ELA V T +++ + +H A+ +++ + ++
Sbjct: 2369 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREK 2427
Query: 406 NFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQV---------------EEKRRKKQL 450
L+ LL E + ++++ L+ +A+ +EK + +QL
Sbjct: 2428 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2487
Query: 451 ------EEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQR 504
+ +Q ++E+Q ++ ++ QER+ + EE +Q + EE + K EL Q Q+
Sbjct: 2488 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2547
Query: 505 AQELAQRLKQE-QRIRELAQ 523
++ + L +E QR+RE Q
Sbjct: 2548 RRQQEELLAEENQRLREQLQ 2567
Score = 52.8 bits (125), Expect = 1e-06
Identities = 166/907 (18%), Positives = 336/907 (37%), Gaps = 134/907 (14%)
Query: 63 KQCIDKDCLHIQKEISPATPNMQ-------KTRNTVNTSLVGKQKPHKK-HITAENMKSS 114
+Q ++++ +Q+E + AT Q K R + L K + ++ T+E K
Sbjct: 1697 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1756
Query: 115 LVCLTQDQLQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTE 174
L + + + + R +L E EAK Q L + Q +
Sbjct: 1757 L----EAEAGRFRELAEEAARLRALAE---EAKRQRQLAEEDAARQRAE----------- 1798
Query: 175 MVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGEREC-DRSSLEAKKAQW 233
V AE + + E T + E +IA++ + + L E E R LE + AQ
Sbjct: 1799 -AERVLAEKLAAIGE--ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1855
Query: 234 RKELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQE 293
+ +++E++A +K + SE ++ +K + D R+ +E A+K
Sbjct: 1856 KADIEERLAQLRKASD-----------SELER---QKGLVEDTLRQRRQVEEEILALKAS 1901
Query: 294 LQRKWIEELNKQIEDDRQRKIEEKIIYSK--------------GEEHDRWAMHFDSLKSY 339
++ + ++E R R E + SK EE R + ++
Sbjct: 1902 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1961
Query: 340 PGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEE---EHIAKPIKD 396
++ + Q E + +E + + Q++ ++E + + K
Sbjct: 1962 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2021
Query: 397 VVMANSKKTNFLRSMT----ALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEE 452
A +K L+ ++LD + E RR + + + A+ E + ++Q+EE
Sbjct: 2022 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2081
Query: 453 EQRKKEEQEEELRLAQE----REEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQR---- 504
+R K+ EE+ + + E+++K+ E++ ++ Q E+ + M++
Sbjct: 2082 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF 2141
Query: 505 -AQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDEISGKM 563
Q L Q+ + EQ + L + +T L + +++ A+ + R +E +
Sbjct: 2142 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2201
Query: 564 NTYMNSTTSKK-------DTGVQTDDLNIGIFTNAESHCGSLMERDITNCSSPEISAELI 616
M + K + D N F E+ + + S A +
Sbjct: 2202 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2261
Query: 617 GQFSTKKNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQTKHMKKYPKRPDWNINKPPK 676
Q + +++L Q + A EK + TR++ + + +++ + + +
Sbjct: 2262 RQLA----EEDLAQQR-ALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL----AQEQAR 2312
Query: 677 RYIPASEKYPKQLQKQRE------EKKVRRQMELLHLVE--KNNPGHLSQNRGISPE--- 725
R E+ +QL ++ + E + +RQ+E+ E K +S+ + + E
Sbjct: 2313 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2372
Query: 726 IFHSSHQETESKL-RWHLVKKEEEPL----------NIHSFSKERSPSSPVPVVKNRTQQ 774
F +E KL R L +E+ L + H + R + + K + QQ
Sbjct: 2373 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2432
Query: 775 TQNTLHLPLKNSSYERENLISGSNQTELSSGISESSHFIPYVRTNE-----IYYLDPDAP 829
L L + ++ + Q S +SE + R E + L D
Sbjct: 2433 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2492
Query: 830 LSGPSTQDPQYQNSQDCGQKRQLFDSDCVRDPLLNPNMVKNRDRQQAILKGLSELRQGLL 889
++ Q + Q Q+RQ L +M + R RQ E +G+
Sbjct: 2493 AKAQQLREEQQRQQQQMEQERQ----------RLVASMEEARRRQH-------EAEEGVR 2535
Query: 890 QKQKELE 896
+KQ+EL+
Sbjct: 2536 RKQEELQ 2542
Score = 42.7 bits (99), Expect = 0.002
Identities = 65/312 (20%), Positives = 128/312 (41%), Gaps = 64/312 (20%)
Query: 191 QETSKQCEQKIAIENEWKPADIFSTLGER-----ECDRSSL---EAKKAQWRKELDEQVA 242
QE +Q Q++A E + + + + E +R L E +AQ R E D Q
Sbjct: 2315 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ-R 2373
Query: 243 LKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEEL 302
+K+ +E+ EK + ++ EK ++ +T+ ++ S E R+ I EL
Sbjct: 2374 FRKQAEEIGEKLH------RTELATQEKVTLV----QTLEIQRQQSDHDAERLREAIAEL 2423
Query: 303 NKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSP 362
++ E +Q E K++ K EE Q QL ++ Q +
Sbjct: 2424 EREKEKLQQ---EAKLLQLKSEEMQTV------------QQEQLLQETQALQQSFL---- 2464
Query: 363 DTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEE 422
SE++ + + + + +K + A Q+ E
Sbjct: 2465 ----------------------SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ--QLRE 2500
Query: 423 RDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDIL 482
+R+Q+Q+E ++ E+ R++Q E E+ + +QEE +L Q+R + ++ E+
Sbjct: 2501 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE-- 2558
Query: 483 KQKQKEEIMTLK 494
Q+ +E++ L+
Sbjct: 2559 NQRLREQLQLLE 2570
Score = 37.0 bits (84), Expect = 0.084
Identities = 44/171 (25%), Positives = 78/171 (45%), Gaps = 14/171 (8%)
Query: 366 ELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQ-IEERD 424
E V ++ P+ + SE E ++ V ++ L++++ ++ Q EE
Sbjct: 1014 EAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVL 1073
Query: 425 RRRQKQLEHQKAITAQVEE--------KRRKKQLEEEQRKKEEQEEELRLAQEREE--MQ 474
R ++QL+ +A+ A + E K+ + Q E +Q + +ELR AQE E Q
Sbjct: 1074 RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQ 1133
Query: 475 KQYEEDILKQKQKEEIMTLKTN---ELFQTMQRAQELAQRLKQEQRIRELA 522
+ E D+ ++ +E + L L QT R +EL Q +Q + RE A
Sbjct: 1134 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1184
Score = 33.1 bits (74), Expect = 1.2
Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 31/137 (22%)
Query: 425 RRRQKQLEHQKAITAQ-VEEKRRKKQ--LEEEQRKKEEQEEELRLAQEREEMQKQYEEDI 481
RRRQ+Q++ +Q V E+ R++Q LEE +R E+ EE R A++ K YE +
Sbjct: 1195 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL 1254
Query: 482 LKQKQK---------------------EEIMTLKTNELFQTMQRAQ------ELAQRLKQ 514
+ K + +E + L+T+ T +Q E +R+++
Sbjct: 1255 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1314
Query: 515 EQRIRELAQKGHDTSRL 531
E+R+ E Q+ + RL
Sbjct: 1315 EERLAE-QQRAEERERL 1330
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 63.2 bits (152), Expect = 1e-09
Identities = 99/455 (21%), Positives = 187/455 (41%), Gaps = 43/455 (9%)
Query: 74 QKEISPATPNMQKTRNTVNTSLVGKQKPH--KKHITAENMKSSLVCLTQDQLQQILMTVN 131
QK ++ A QK GK + ++ AE L + QQ L
Sbjct: 1791 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1850
Query: 132 QGNRSLSLTENGKEAKSQYSLYLNSI------SNQPKDENIMGLFKKTEMVSSVPAENKS 185
+ R + TE G++ + L + + Q + E L K + + A
Sbjct: 1851 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1910
Query: 186 VLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQVALKK 245
E + TS++ +Q++ E A F L E E R A++A+ +++L E+ A ++
Sbjct: 1911 AEEESRSTSEKSKQRLEAE-----AGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQ 1964
Query: 246 KEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEELNKQ 305
+ +E+++++ EK + ++ T L A+K++ E L +
Sbjct: 1965 R--------------AEAERVLAEKLAAIGEA--TRLKTEAEIALKEKEAEN--ERLRRL 2006
Query: 306 IEDD--RQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSPD 363
ED+ ++R++EE+ K + +R A + S Q L + ++ + +
Sbjct: 2007 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV-----E 2061
Query: 364 TQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEER 423
+ LA +S G E I +D + SK+ L + A EE
Sbjct: 2062 EEILALKASFEKAAAGKAELELELGRIRSNAEDTL--RSKEQAELEA--ARQRQLAAEEE 2117
Query: 424 DRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILK 483
RRR+ + QK++ A+ E R++K EE + + + EE R +ER E + + + +
Sbjct: 2118 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2177
Query: 484 QKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRI 518
+ ++ + + F Q+ QEL Q L+QEQ +
Sbjct: 2178 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2212
Score = 60.5 bits (145), Expect = 7e-09
Identities = 116/633 (18%), Positives = 260/633 (41%), Gaps = 87/633 (13%)
Query: 123 LQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLF--KKTEMVSSVP 180
L+++ + + R L E + + Q +L S + + ++ F K ++ S+
Sbjct: 1675 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1734
Query: 181 AENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQ 240
E+ +V +E ++ +Q+ E + A ERE +R W+ + +E
Sbjct: 1735 EEHVAVAQLREEAERRAQQQAEAERAREEA-------ERELER---------WQLKANEA 1778
Query: 241 VALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQ-ELQRKWI 299
+ L+ + +EV+++ ++E++K +K + ++R E AV+Q EL + +
Sbjct: 1779 LRLRLQAEEVAQQ--KSLAQAEAEK---QKEEAEREARRRGKAEE--QAVRQRELAEQEL 1831
Query: 300 EELNKQIEDDRQRKI--EEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEY 357
E+ + E Q+++ E+++I + E G Q + +
Sbjct: 1832 EKQRQLAEGTAQQRLAAEQELIRLRAETEQ-------------GEQQRQLLE-------- 1870
Query: 358 FCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDP 417
+ELA + T + E E + +V++A+ + T+
Sbjct: 1871 -------EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1923
Query: 418 AQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQE----REEM 473
++E R ++ E + A EE +R++QL EE ++ E E LA++ E
Sbjct: 1924 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1983
Query: 474 QKQYEEDIL---KQKQKEEIMTLKTNELFQTMQRAQELAQ-RLKQEQRIRELAQKGHDTS 529
+ + E +I K+ + E + L +E FQ + ++ AQ + E+R+ +L +
Sbjct: 1984 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 2043
Query: 530 RLIKNLGVDTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIG-IF 588
K L DT++ R +EI ++ + K + +L +G I
Sbjct: 2044 ERQKGLVEDTLRQR---------RQVEEEILALKASFEKAAAGKAEL-----ELELGRIR 2089
Query: 589 TNAESHCGSLMERDITNCSSPEISAELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCN 648
+NAE S + ++ +++AE + ++ +E Q A+ E+ +
Sbjct: 2090 SNAEDTLRSKEQAELEAARQRQLAAE---EERRRREAEERVQKSLAAEEEAARQRKAALE 2146
Query: 649 QFTRIEKQTKHMKKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEK--KVRRQMELLH 706
+ R++ + + ++ +R + + ++ A E K+LQ + + V+++ + L
Sbjct: 2147 EVERLKAKVEEARRLRERAE---QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2203
Query: 707 LVEKNNPGHLSQNRGISPEIFHSSHQETESKLR 739
+ L Q RG + ++ + E++++
Sbjct: 2204 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2236
Score = 58.2 bits (139), Expect = 4e-08
Identities = 77/391 (19%), Positives = 166/391 (42%), Gaps = 46/391 (11%)
Query: 179 VPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELD 238
V + ++SV+ E+ + + + +++ I TL E + E ++A+ R+ L
Sbjct: 1442 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKF-ISETLRRMEEEERLAEQQRAEERERLA 1500
Query: 239 EQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKW 298
E A +K+++++E ++E + + L Q + ++ +AV + Q++
Sbjct: 1501 EVEAALEKQRQLAEAHAQAKAQAEREA------KELQQRMQEEVVRREEAAVDAQQQKRS 1554
Query: 299 IEELNKQIEDDRQRKIEEKIIYSKGEEHDRWA---------MHFDSLKSYPGSQSQLFSQ 349
I+E +Q+ + +I+ K ++ E R + ++ + G
Sbjct: 1555 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1614
Query: 350 STHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLR 409
+ E QE A+ + +E E +A +K A +K L+
Sbjct: 1615 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE-LASRVKAEAEAAREKQRALQ 1673
Query: 410 SMTALLDPAQIEERDRR-RQKQLEH-----------QKAITAQVEEKRRKKQLEEEQRKK 457
++ L Q EE +RR RQ ++E Q++ A+++ KR + Q ++
Sbjct: 1674 ALEELR--LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1731
Query: 458 EEQEEELRLAQEREEMQKQYEEDILKQKQKEEI------MTLKTNELFQTMQRAQELAQR 511
QEE + +AQ REE +++ ++ ++ +EE LK NE + +A+E+AQ+
Sbjct: 1732 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1791
Query: 512 ---------LKQEQRIRELAQKGHDTSRLIK 533
++E+ RE ++G + ++
Sbjct: 1792 KSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1822
Score = 57.8 bits (138), Expect = 5e-08
Identities = 77/380 (20%), Positives = 174/380 (45%), Gaps = 50/380 (13%)
Query: 173 TEMVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQ 232
+++ + + AEN++++ ++ +++ Q+ A+ + E E R S+ A++A
Sbjct: 2378 SKLKARIEAENRALILRDKDNTQRFLQE--------EAEKMKQVAE-EAARLSVAAQEAA 2428
Query: 233 WRKELDEQVALKKK---EKEVSEKWNDPWK----KSESDKIIWEKHQILDQSRETVLLEH 285
++L E+ +++ EK + EK + K+E++ + +K +Q+R L+
Sbjct: 2429 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR---LQE 2485
Query: 286 PFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQ 345
+ Q+L + + + +E +RQR++E E +R + + S ++++
Sbjct: 2486 DKEQMAQQLAEE-TQGFQRTLEAERQRQLE------MSAEAERLKLRVAEM-SRAQARAE 2537
Query: 346 LFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKT 405
+Q KQ E ELA V T +++ + +H A+ +++ + ++
Sbjct: 2538 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREK 2596
Query: 406 NFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQV---------------EEKRRKKQL 450
L+ LL E + ++++ L+ +A+ +EK + +QL
Sbjct: 2597 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2656
Query: 451 ------EEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQR 504
+ +Q ++E+Q ++ ++ QER+ + EE +Q + EE + K EL Q Q+
Sbjct: 2657 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2716
Query: 505 AQELAQRLKQE-QRIRELAQ 523
++ + L +E QR+RE Q
Sbjct: 2717 RRQQEELLAEENQRLREQLQ 2736
Score = 52.8 bits (125), Expect = 1e-06
Identities = 166/907 (18%), Positives = 336/907 (37%), Gaps = 134/907 (14%)
Query: 63 KQCIDKDCLHIQKEISPATPNMQ-------KTRNTVNTSLVGKQKPHKK-HITAENMKSS 114
+Q ++++ +Q+E + AT Q K R + L K + ++ T+E K
Sbjct: 1866 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1925
Query: 115 LVCLTQDQLQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTE 174
L + + + + R +L E EAK Q L + Q +
Sbjct: 1926 L----EAEAGRFRELAEEAARLRALAE---EAKRQRQLAEEDAARQRAE----------- 1967
Query: 175 MVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGEREC-DRSSLEAKKAQW 233
V AE + + E T + E +IA++ + + L E E R LE + AQ
Sbjct: 1968 -AERVLAEKLAAIGE--ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 2024
Query: 234 RKELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQE 293
+ +++E++A +K + SE ++ +K + D R+ +E A+K
Sbjct: 2025 KADIEERLAQLRKASD-----------SELER---QKGLVEDTLRQRRQVEEEILALKAS 2070
Query: 294 LQRKWIEELNKQIEDDRQRKIEEKIIYSK--------------GEEHDRWAMHFDSLKSY 339
++ + ++E R R E + SK EE R + ++
Sbjct: 2071 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 2130
Query: 340 PGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEE---EHIAKPIKD 396
++ + Q E + +E + + Q++ ++E + + K
Sbjct: 2131 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2190
Query: 397 VVMANSKKTNFLRSMT----ALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEE 452
A +K L+ ++LD + E RR + + + A+ E + ++Q+EE
Sbjct: 2191 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2250
Query: 453 EQRKKEEQEEELRLAQE----REEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQR---- 504
+R K+ EE+ + + E+++K+ E++ ++ Q E+ + M++
Sbjct: 2251 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF 2310
Query: 505 -AQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDEISGKM 563
Q L Q+ + EQ + L + +T L + +++ A+ + R +E +
Sbjct: 2311 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2370
Query: 564 NTYMNSTTSKK-------DTGVQTDDLNIGIFTNAESHCGSLMERDITNCSSPEISAELI 616
M + K + D N F E+ + + S A +
Sbjct: 2371 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2430
Query: 617 GQFSTKKNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQTKHMKKYPKRPDWNINKPPK 676
Q + +++L Q + A EK + TR++ + + +++ + + +
Sbjct: 2431 RQLA----EEDLAQQR-ALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL----AQEQAR 2481
Query: 677 RYIPASEKYPKQLQKQRE------EKKVRRQMELLHLVE--KNNPGHLSQNRGISPE--- 725
R E+ +QL ++ + E + +RQ+E+ E K +S+ + + E
Sbjct: 2482 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2541
Query: 726 IFHSSHQETESKL-RWHLVKKEEEPL----------NIHSFSKERSPSSPVPVVKNRTQQ 774
F +E KL R L +E+ L + H + R + + K + QQ
Sbjct: 2542 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2601
Query: 775 TQNTLHLPLKNSSYERENLISGSNQTELSSGISESSHFIPYVRTNE-----IYYLDPDAP 829
L L + ++ + Q S +SE + R E + L D
Sbjct: 2602 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2661
Query: 830 LSGPSTQDPQYQNSQDCGQKRQLFDSDCVRDPLLNPNMVKNRDRQQAILKGLSELRQGLL 889
++ Q + Q Q+RQ L +M + R RQ E +G+
Sbjct: 2662 AKAQQLREEQQRQQQQMEQERQ----------RLVASMEEARRRQH-------EAEEGVR 2704
Query: 890 QKQKELE 896
+KQ+EL+
Sbjct: 2705 RKQEELQ 2711
Score = 42.7 bits (99), Expect = 0.002
Identities = 65/312 (20%), Positives = 128/312 (41%), Gaps = 64/312 (20%)
Query: 191 QETSKQCEQKIAIENEWKPADIFSTLGER-----ECDRSSL---EAKKAQWRKELDEQVA 242
QE +Q Q++A E + + + + E +R L E +AQ R E D Q
Sbjct: 2484 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ-R 2542
Query: 243 LKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEEL 302
+K+ +E+ EK + ++ EK ++ +T+ ++ S E R+ I EL
Sbjct: 2543 FRKQAEEIGEKLH------RTELATQEKVTLV----QTLEIQRQQSDHDAERLREAIAEL 2592
Query: 303 NKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSP 362
++ E +Q E K++ K EE Q QL ++ Q +
Sbjct: 2593 EREKEKLQQ---EAKLLQLKSEEMQTV------------QQEQLLQETQALQQSFL---- 2633
Query: 363 DTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEE 422
SE++ + + + + +K + A Q+ E
Sbjct: 2634 ----------------------SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ--QLRE 2669
Query: 423 RDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDIL 482
+R+Q+Q+E ++ E+ R++Q E E+ + +QEE +L Q+R + ++ E+
Sbjct: 2670 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE-- 2727
Query: 483 KQKQKEEIMTLK 494
Q+ +E++ L+
Sbjct: 2728 NQRLREQLQLLE 2739
Score = 37.0 bits (84), Expect = 0.084
Identities = 44/171 (25%), Positives = 78/171 (45%), Gaps = 14/171 (8%)
Query: 366 ELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQ-IEERD 424
E V ++ P+ + SE E ++ V ++ L++++ ++ Q EE
Sbjct: 1183 EAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVL 1242
Query: 425 RRRQKQLEHQKAITAQVEE--------KRRKKQLEEEQRKKEEQEEELRLAQEREE--MQ 474
R ++QL+ +A+ A + E K+ + Q E +Q + +ELR AQE E Q
Sbjct: 1243 RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQ 1302
Query: 475 KQYEEDILKQKQKEEIMTLKTN---ELFQTMQRAQELAQRLKQEQRIRELA 522
+ E D+ ++ +E + L L QT R +EL Q +Q + RE A
Sbjct: 1303 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1353
Score = 33.1 bits (74), Expect = 1.2
Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 31/137 (22%)
Query: 425 RRRQKQLEHQKAITAQ-VEEKRRKKQ--LEEEQRKKEEQEEELRLAQEREEMQKQYEEDI 481
RRRQ+Q++ +Q V E+ R++Q LEE +R E+ EE R A++ K YE +
Sbjct: 1364 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL 1423
Query: 482 LKQKQK---------------------EEIMTLKTNELFQTMQRAQ------ELAQRLKQ 514
+ K + +E + L+T+ T +Q E +R+++
Sbjct: 1424 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1483
Query: 515 EQRIRELAQKGHDTSRL 531
E+R+ E Q+ + RL
Sbjct: 1484 EERLAE-QQRAEERERL 1499
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 63.2 bits (152), Expect = 1e-09
Identities = 99/455 (21%), Positives = 187/455 (41%), Gaps = 43/455 (9%)
Query: 74 QKEISPATPNMQKTRNTVNTSLVGKQKPH--KKHITAENMKSSLVCLTQDQLQQILMTVN 131
QK ++ A QK GK + ++ AE L + QQ L
Sbjct: 1632 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1691
Query: 132 QGNRSLSLTENGKEAKSQYSLYLNSI------SNQPKDENIMGLFKKTEMVSSVPAENKS 185
+ R + TE G++ + L + + Q + E L K + + A
Sbjct: 1692 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1751
Query: 186 VLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQVALKK 245
E + TS++ +Q++ E A F L E E R A++A+ +++L E+ A ++
Sbjct: 1752 AEEESRSTSEKSKQRLEAE-----AGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQ 1805
Query: 246 KEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEELNKQ 305
+ +E+++++ EK + ++ T L A+K++ E L +
Sbjct: 1806 R--------------AEAERVLAEKLAAIGEA--TRLKTEAEIALKEKEAEN--ERLRRL 1847
Query: 306 IEDD--RQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSPD 363
ED+ ++R++EE+ K + +R A + S Q L + ++ + +
Sbjct: 1848 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV-----E 1902
Query: 364 TQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEER 423
+ LA +S G E I +D + SK+ L + A EE
Sbjct: 1903 EEILALKASFEKAAAGKAELELELGRIRSNAEDTL--RSKEQAELEA--ARQRQLAAEEE 1958
Query: 424 DRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILK 483
RRR+ + QK++ A+ E R++K EE + + + EE R +ER E + + + +
Sbjct: 1959 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2018
Query: 484 QKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRI 518
+ ++ + + F Q+ QEL Q L+QEQ +
Sbjct: 2019 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2053
Score = 60.5 bits (145), Expect = 7e-09
Identities = 116/633 (18%), Positives = 260/633 (41%), Gaps = 87/633 (13%)
Query: 123 LQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLF--KKTEMVSSVP 180
L+++ + + R L E + + Q +L S + + ++ F K ++ S+
Sbjct: 1516 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1575
Query: 181 AENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQ 240
E+ +V +E ++ +Q+ E + A ERE +R W+ + +E
Sbjct: 1576 EEHVAVAQLREEAERRAQQQAEAERAREEA-------ERELER---------WQLKANEA 1619
Query: 241 VALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQ-ELQRKWI 299
+ L+ + +EV+++ ++E++K +K + ++R E AV+Q EL + +
Sbjct: 1620 LRLRLQAEEVAQQ--KSLAQAEAEK---QKEEAEREARRRGKAEE--QAVRQRELAEQEL 1672
Query: 300 EELNKQIEDDRQRKI--EEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEY 357
E+ + E Q+++ E+++I + E G Q + +
Sbjct: 1673 EKQRQLAEGTAQQRLAAEQELIRLRAETEQ-------------GEQQRQLLE-------- 1711
Query: 358 FCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDP 417
+ELA + T + E E + +V++A+ + T+
Sbjct: 1712 -------EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1764
Query: 418 AQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQE----REEM 473
++E R ++ E + A EE +R++QL EE ++ E E LA++ E
Sbjct: 1765 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1824
Query: 474 QKQYEEDIL---KQKQKEEIMTLKTNELFQTMQRAQELAQ-RLKQEQRIRELAQKGHDTS 529
+ + E +I K+ + E + L +E FQ + ++ AQ + E+R+ +L +
Sbjct: 1825 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1884
Query: 530 RLIKNLGVDTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIG-IF 588
K L DT++ R +EI ++ + K + +L +G I
Sbjct: 1885 ERQKGLVEDTLRQR---------RQVEEEILALKASFEKAAAGKAEL-----ELELGRIR 1930
Query: 589 TNAESHCGSLMERDITNCSSPEISAELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCN 648
+NAE S + ++ +++AE + ++ +E Q A+ E+ +
Sbjct: 1931 SNAEDTLRSKEQAELEAARQRQLAAE---EERRRREAEERVQKSLAAEEEAARQRKAALE 1987
Query: 649 QFTRIEKQTKHMKKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEK--KVRRQMELLH 706
+ R++ + + ++ +R + + ++ A E K+LQ + + V+++ + L
Sbjct: 1988 EVERLKAKVEEARRLRERAE---QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2044
Query: 707 LVEKNNPGHLSQNRGISPEIFHSSHQETESKLR 739
+ L Q RG + ++ + E++++
Sbjct: 2045 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2077
Score = 58.2 bits (139), Expect = 4e-08
Identities = 77/391 (19%), Positives = 166/391 (42%), Gaps = 46/391 (11%)
Query: 179 VPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELD 238
V + ++SV+ E+ + + + +++ I TL E + E ++A+ R+ L
Sbjct: 1283 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKF-ISETLRRMEEEERLAEQQRAEERERLA 1341
Query: 239 EQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKW 298
E A +K+++++E ++E + + L Q + ++ +AV + Q++
Sbjct: 1342 EVEAALEKQRQLAEAHAQAKAQAEREA------KELQQRMQEEVVRREEAAVDAQQQKRS 1395
Query: 299 IEELNKQIEDDRQRKIEEKIIYSKGEEHDRWA---------MHFDSLKSYPGSQSQLFSQ 349
I+E +Q+ + +I+ K ++ E R + ++ + G
Sbjct: 1396 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1455
Query: 350 STHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLR 409
+ E QE A+ + +E E +A +K A +K L+
Sbjct: 1456 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE-LASRVKAEAEAAREKQRALQ 1514
Query: 410 SMTALLDPAQIEERDRR-RQKQLEH-----------QKAITAQVEEKRRKKQLEEEQRKK 457
++ L Q EE +RR RQ ++E Q++ A+++ KR + Q ++
Sbjct: 1515 ALEELR--LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1572
Query: 458 EEQEEELRLAQEREEMQKQYEEDILKQKQKEEI------MTLKTNELFQTMQRAQELAQR 511
QEE + +AQ REE +++ ++ ++ +EE LK NE + +A+E+AQ+
Sbjct: 1573 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1632
Query: 512 ---------LKQEQRIRELAQKGHDTSRLIK 533
++E+ RE ++G + ++
Sbjct: 1633 KSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1663
Score = 57.8 bits (138), Expect = 5e-08
Identities = 77/380 (20%), Positives = 174/380 (45%), Gaps = 50/380 (13%)
Query: 173 TEMVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQ 232
+++ + + AEN++++ ++ +++ Q+ A+ + E E R S+ A++A
Sbjct: 2219 SKLKARIEAENRALILRDKDNTQRFLQE--------EAEKMKQVAE-EAARLSVAAQEAA 2269
Query: 233 WRKELDEQVALKKK---EKEVSEKWNDPWK----KSESDKIIWEKHQILDQSRETVLLEH 285
++L E+ +++ EK + EK + K+E++ + +K +Q+R L+
Sbjct: 2270 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR---LQE 2326
Query: 286 PFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQ 345
+ Q+L + + + +E +RQR++E E +R + + S ++++
Sbjct: 2327 DKEQMAQQLAEE-TQGFQRTLEAERQRQLE------MSAEAERLKLRVAEM-SRAQARAE 2378
Query: 346 LFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKT 405
+Q KQ E ELA V T +++ + +H A+ +++ + ++
Sbjct: 2379 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREK 2437
Query: 406 NFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQV---------------EEKRRKKQL 450
L+ LL E + ++++ L+ +A+ +EK + +QL
Sbjct: 2438 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2497
Query: 451 ------EEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQR 504
+ +Q ++E+Q ++ ++ QER+ + EE +Q + EE + K EL Q Q+
Sbjct: 2498 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2557
Query: 505 AQELAQRLKQE-QRIRELAQ 523
++ + L +E QR+RE Q
Sbjct: 2558 RRQQEELLAEENQRLREQLQ 2577
Score = 52.8 bits (125), Expect = 1e-06
Identities = 166/907 (18%), Positives = 336/907 (37%), Gaps = 134/907 (14%)
Query: 63 KQCIDKDCLHIQKEISPATPNMQ-------KTRNTVNTSLVGKQKPHKK-HITAENMKSS 114
+Q ++++ +Q+E + AT Q K R + L K + ++ T+E K
Sbjct: 1707 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1766
Query: 115 LVCLTQDQLQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTE 174
L + + + + R +L E EAK Q L + Q +
Sbjct: 1767 L----EAEAGRFRELAEEAARLRALAE---EAKRQRQLAEEDAARQRAE----------- 1808
Query: 175 MVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGEREC-DRSSLEAKKAQW 233
V AE + + E T + E +IA++ + + L E E R LE + AQ
Sbjct: 1809 -AERVLAEKLAAIGE--ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1865
Query: 234 RKELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQE 293
+ +++E++A +K + SE ++ +K + D R+ +E A+K
Sbjct: 1866 KADIEERLAQLRKASD-----------SELER---QKGLVEDTLRQRRQVEEEILALKAS 1911
Query: 294 LQRKWIEELNKQIEDDRQRKIEEKIIYSK--------------GEEHDRWAMHFDSLKSY 339
++ + ++E R R E + SK EE R + ++
Sbjct: 1912 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1971
Query: 340 PGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEE---EHIAKPIKD 396
++ + Q E + +E + + Q++ ++E + + K
Sbjct: 1972 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2031
Query: 397 VVMANSKKTNFLRSMT----ALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEE 452
A +K L+ ++LD + E RR + + + A+ E + ++Q+EE
Sbjct: 2032 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2091
Query: 453 EQRKKEEQEEELRLAQE----REEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQR---- 504
+R K+ EE+ + + E+++K+ E++ ++ Q E+ + M++
Sbjct: 2092 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF 2151
Query: 505 -AQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDEISGKM 563
Q L Q+ + EQ + L + +T L + +++ A+ + R +E +
Sbjct: 2152 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2211
Query: 564 NTYMNSTTSKK-------DTGVQTDDLNIGIFTNAESHCGSLMERDITNCSSPEISAELI 616
M + K + D N F E+ + + S A +
Sbjct: 2212 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2271
Query: 617 GQFSTKKNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQTKHMKKYPKRPDWNINKPPK 676
Q + +++L Q + A EK + TR++ + + +++ + + +
Sbjct: 2272 RQLA----EEDLAQQR-ALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL----AQEQAR 2322
Query: 677 RYIPASEKYPKQLQKQRE------EKKVRRQMELLHLVE--KNNPGHLSQNRGISPE--- 725
R E+ +QL ++ + E + +RQ+E+ E K +S+ + + E
Sbjct: 2323 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2382
Query: 726 IFHSSHQETESKL-RWHLVKKEEEPL----------NIHSFSKERSPSSPVPVVKNRTQQ 774
F +E KL R L +E+ L + H + R + + K + QQ
Sbjct: 2383 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2442
Query: 775 TQNTLHLPLKNSSYERENLISGSNQTELSSGISESSHFIPYVRTNE-----IYYLDPDAP 829
L L + ++ + Q S +SE + R E + L D
Sbjct: 2443 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2502
Query: 830 LSGPSTQDPQYQNSQDCGQKRQLFDSDCVRDPLLNPNMVKNRDRQQAILKGLSELRQGLL 889
++ Q + Q Q+RQ L +M + R RQ E +G+
Sbjct: 2503 AKAQQLREEQQRQQQQMEQERQ----------RLVASMEEARRRQH-------EAEEGVR 2545
Query: 890 QKQKELE 896
+KQ+EL+
Sbjct: 2546 RKQEELQ 2552
Score = 42.7 bits (99), Expect = 0.002
Identities = 65/312 (20%), Positives = 128/312 (41%), Gaps = 64/312 (20%)
Query: 191 QETSKQCEQKIAIENEWKPADIFSTLGER-----ECDRSSL---EAKKAQWRKELDEQVA 242
QE +Q Q++A E + + + + E +R L E +AQ R E D Q
Sbjct: 2325 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ-R 2383
Query: 243 LKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEEL 302
+K+ +E+ EK + ++ EK ++ +T+ ++ S E R+ I EL
Sbjct: 2384 FRKQAEEIGEKLH------RTELATQEKVTLV----QTLEIQRQQSDHDAERLREAIAEL 2433
Query: 303 NKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSP 362
++ E +Q E K++ K EE Q QL ++ Q +
Sbjct: 2434 EREKEKLQQ---EAKLLQLKSEEMQTV------------QQEQLLQETQALQQSFL---- 2474
Query: 363 DTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEE 422
SE++ + + + + +K + A Q+ E
Sbjct: 2475 ----------------------SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ--QLRE 2510
Query: 423 RDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDIL 482
+R+Q+Q+E ++ E+ R++Q E E+ + +QEE +L Q+R + ++ E+
Sbjct: 2511 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE-- 2568
Query: 483 KQKQKEEIMTLK 494
Q+ +E++ L+
Sbjct: 2569 NQRLREQLQLLE 2580
Score = 37.0 bits (84), Expect = 0.084
Identities = 44/171 (25%), Positives = 78/171 (45%), Gaps = 14/171 (8%)
Query: 366 ELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQ-IEERD 424
E V ++ P+ + SE E ++ V ++ L++++ ++ Q EE
Sbjct: 1024 EAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVL 1083
Query: 425 RRRQKQLEHQKAITAQVEE--------KRRKKQLEEEQRKKEEQEEELRLAQEREE--MQ 474
R ++QL+ +A+ A + E K+ + Q E +Q + +ELR AQE E Q
Sbjct: 1084 RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQ 1143
Query: 475 KQYEEDILKQKQKEEIMTLKTN---ELFQTMQRAQELAQRLKQEQRIRELA 522
+ E D+ ++ +E + L L QT R +EL Q +Q + RE A
Sbjct: 1144 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1194
Score = 33.1 bits (74), Expect = 1.2
Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 31/137 (22%)
Query: 425 RRRQKQLEHQKAITAQ-VEEKRRKKQ--LEEEQRKKEEQEEELRLAQEREEMQKQYEEDI 481
RRRQ+Q++ +Q V E+ R++Q LEE +R E+ EE R A++ K YE +
Sbjct: 1205 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL 1264
Query: 482 LKQKQK---------------------EEIMTLKTNELFQTMQRAQ------ELAQRLKQ 514
+ K + +E + L+T+ T +Q E +R+++
Sbjct: 1265 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1324
Query: 515 EQRIRELAQKGHDTSRL 531
E+R+ E Q+ + RL
Sbjct: 1325 EERLAE-QQRAEERERL 1340
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 63.2 bits (152), Expect = 1e-09
Identities = 99/455 (21%), Positives = 187/455 (41%), Gaps = 43/455 (9%)
Query: 74 QKEISPATPNMQKTRNTVNTSLVGKQKPH--KKHITAENMKSSLVCLTQDQLQQILMTVN 131
QK ++ A QK GK + ++ AE L + QQ L
Sbjct: 1640 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1699
Query: 132 QGNRSLSLTENGKEAKSQYSLYLNSI------SNQPKDENIMGLFKKTEMVSSVPAENKS 185
+ R + TE G++ + L + + Q + E L K + + A
Sbjct: 1700 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1759
Query: 186 VLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQVALKK 245
E + TS++ +Q++ E A F L E E R A++A+ +++L E+ A ++
Sbjct: 1760 AEEESRSTSEKSKQRLEAE-----AGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQ 1813
Query: 246 KEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEELNKQ 305
+ +E+++++ EK + ++ T L A+K++ E L +
Sbjct: 1814 R--------------AEAERVLAEKLAAIGEA--TRLKTEAEIALKEKEAEN--ERLRRL 1855
Query: 306 IEDD--RQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSPD 363
ED+ ++R++EE+ K + +R A + S Q L + ++ + +
Sbjct: 1856 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV-----E 1910
Query: 364 TQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEER 423
+ LA +S G E I +D + SK+ L + A EE
Sbjct: 1911 EEILALKASFEKAAAGKAELELELGRIRSNAEDTL--RSKEQAELEA--ARQRQLAAEEE 1966
Query: 424 DRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILK 483
RRR+ + QK++ A+ E R++K EE + + + EE R +ER E + + + +
Sbjct: 1967 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2026
Query: 484 QKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRI 518
+ ++ + + F Q+ QEL Q L+QEQ +
Sbjct: 2027 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2061
Score = 60.5 bits (145), Expect = 7e-09
Identities = 116/633 (18%), Positives = 260/633 (41%), Gaps = 87/633 (13%)
Query: 123 LQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLF--KKTEMVSSVP 180
L+++ + + R L E + + Q +L S + + ++ F K ++ S+
Sbjct: 1524 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1583
Query: 181 AENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQ 240
E+ +V +E ++ +Q+ E + A ERE +R W+ + +E
Sbjct: 1584 EEHVAVAQLREEAERRAQQQAEAERAREEA-------ERELER---------WQLKANEA 1627
Query: 241 VALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQ-ELQRKWI 299
+ L+ + +EV+++ ++E++K +K + ++R E AV+Q EL + +
Sbjct: 1628 LRLRLQAEEVAQQ--KSLAQAEAEK---QKEEAEREARRRGKAEE--QAVRQRELAEQEL 1680
Query: 300 EELNKQIEDDRQRKI--EEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEY 357
E+ + E Q+++ E+++I + E G Q + +
Sbjct: 1681 EKQRQLAEGTAQQRLAAEQELIRLRAETEQ-------------GEQQRQLLE-------- 1719
Query: 358 FCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDP 417
+ELA + T + E E + +V++A+ + T+
Sbjct: 1720 -------EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1772
Query: 418 AQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQE----REEM 473
++E R ++ E + A EE +R++QL EE ++ E E LA++ E
Sbjct: 1773 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1832
Query: 474 QKQYEEDIL---KQKQKEEIMTLKTNELFQTMQRAQELAQ-RLKQEQRIRELAQKGHDTS 529
+ + E +I K+ + E + L +E FQ + ++ AQ + E+R+ +L +
Sbjct: 1833 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1892
Query: 530 RLIKNLGVDTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIG-IF 588
K L DT++ R +EI ++ + K + +L +G I
Sbjct: 1893 ERQKGLVEDTLRQR---------RQVEEEILALKASFEKAAAGKAEL-----ELELGRIR 1938
Query: 589 TNAESHCGSLMERDITNCSSPEISAELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCN 648
+NAE S + ++ +++AE + ++ +E Q A+ E+ +
Sbjct: 1939 SNAEDTLRSKEQAELEAARQRQLAAE---EERRRREAEERVQKSLAAEEEAARQRKAALE 1995
Query: 649 QFTRIEKQTKHMKKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEK--KVRRQMELLH 706
+ R++ + + ++ +R + + ++ A E K+LQ + + V+++ + L
Sbjct: 1996 EVERLKAKVEEARRLRERAE---QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2052
Query: 707 LVEKNNPGHLSQNRGISPEIFHSSHQETESKLR 739
+ L Q RG + ++ + E++++
Sbjct: 2053 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2085
Score = 58.2 bits (139), Expect = 4e-08
Identities = 77/391 (19%), Positives = 166/391 (42%), Gaps = 46/391 (11%)
Query: 179 VPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELD 238
V + ++SV+ E+ + + + +++ I TL E + E ++A+ R+ L
Sbjct: 1291 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKF-ISETLRRMEEEERLAEQQRAEERERLA 1349
Query: 239 EQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKW 298
E A +K+++++E ++E + + L Q + ++ +AV + Q++
Sbjct: 1350 EVEAALEKQRQLAEAHAQAKAQAEREA------KELQQRMQEEVVRREEAAVDAQQQKRS 1403
Query: 299 IEELNKQIEDDRQRKIEEKIIYSKGEEHDRWA---------MHFDSLKSYPGSQSQLFSQ 349
I+E +Q+ + +I+ K ++ E R + ++ + G
Sbjct: 1404 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1463
Query: 350 STHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLR 409
+ E QE A+ + +E E +A +K A +K L+
Sbjct: 1464 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE-LASRVKAEAEAAREKQRALQ 1522
Query: 410 SMTALLDPAQIEERDRR-RQKQLEH-----------QKAITAQVEEKRRKKQLEEEQRKK 457
++ L Q EE +RR RQ ++E Q++ A+++ KR + Q ++
Sbjct: 1523 ALEELR--LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1580
Query: 458 EEQEEELRLAQEREEMQKQYEEDILKQKQKEEI------MTLKTNELFQTMQRAQELAQR 511
QEE + +AQ REE +++ ++ ++ +EE LK NE + +A+E+AQ+
Sbjct: 1581 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1640
Query: 512 ---------LKQEQRIRELAQKGHDTSRLIK 533
++E+ RE ++G + ++
Sbjct: 1641 KSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1671
Score = 57.8 bits (138), Expect = 5e-08
Identities = 77/380 (20%), Positives = 174/380 (45%), Gaps = 50/380 (13%)
Query: 173 TEMVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQ 232
+++ + + AEN++++ ++ +++ Q+ A+ + E E R S+ A++A
Sbjct: 2227 SKLKARIEAENRALILRDKDNTQRFLQE--------EAEKMKQVAE-EAARLSVAAQEAA 2277
Query: 233 WRKELDEQVALKKK---EKEVSEKWNDPWK----KSESDKIIWEKHQILDQSRETVLLEH 285
++L E+ +++ EK + EK + K+E++ + +K +Q+R L+
Sbjct: 2278 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR---LQE 2334
Query: 286 PFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQ 345
+ Q+L + + + +E +RQR++E E +R + + S ++++
Sbjct: 2335 DKEQMAQQLAEE-TQGFQRTLEAERQRQLE------MSAEAERLKLRVAEM-SRAQARAE 2386
Query: 346 LFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKT 405
+Q KQ E ELA V T +++ + +H A+ +++ + ++
Sbjct: 2387 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREK 2445
Query: 406 NFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQV---------------EEKRRKKQL 450
L+ LL E + ++++ L+ +A+ +EK + +QL
Sbjct: 2446 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2505
Query: 451 ------EEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQR 504
+ +Q ++E+Q ++ ++ QER+ + EE +Q + EE + K EL Q Q+
Sbjct: 2506 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2565
Query: 505 AQELAQRLKQE-QRIRELAQ 523
++ + L +E QR+RE Q
Sbjct: 2566 RRQQEELLAEENQRLREQLQ 2585
Score = 52.8 bits (125), Expect = 1e-06
Identities = 166/907 (18%), Positives = 336/907 (37%), Gaps = 134/907 (14%)
Query: 63 KQCIDKDCLHIQKEISPATPNMQ-------KTRNTVNTSLVGKQKPHKK-HITAENMKSS 114
+Q ++++ +Q+E + AT Q K R + L K + ++ T+E K
Sbjct: 1715 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1774
Query: 115 LVCLTQDQLQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTE 174
L + + + + R +L E EAK Q L + Q +
Sbjct: 1775 L----EAEAGRFRELAEEAARLRALAE---EAKRQRQLAEEDAARQRAE----------- 1816
Query: 175 MVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGEREC-DRSSLEAKKAQW 233
V AE + + E T + E +IA++ + + L E E R LE + AQ
Sbjct: 1817 -AERVLAEKLAAIGE--ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1873
Query: 234 RKELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQE 293
+ +++E++A +K + SE ++ +K + D R+ +E A+K
Sbjct: 1874 KADIEERLAQLRKASD-----------SELER---QKGLVEDTLRQRRQVEEEILALKAS 1919
Query: 294 LQRKWIEELNKQIEDDRQRKIEEKIIYSK--------------GEEHDRWAMHFDSLKSY 339
++ + ++E R R E + SK EE R + ++
Sbjct: 1920 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1979
Query: 340 PGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEE---EHIAKPIKD 396
++ + Q E + +E + + Q++ ++E + + K
Sbjct: 1980 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2039
Query: 397 VVMANSKKTNFLRSMT----ALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEE 452
A +K L+ ++LD + E RR + + + A+ E + ++Q+EE
Sbjct: 2040 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2099
Query: 453 EQRKKEEQEEELRLAQE----REEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQR---- 504
+R K+ EE+ + + E+++K+ E++ ++ Q E+ + M++
Sbjct: 2100 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF 2159
Query: 505 -AQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDEISGKM 563
Q L Q+ + EQ + L + +T L + +++ A+ + R +E +
Sbjct: 2160 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2219
Query: 564 NTYMNSTTSKK-------DTGVQTDDLNIGIFTNAESHCGSLMERDITNCSSPEISAELI 616
M + K + D N F E+ + + S A +
Sbjct: 2220 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2279
Query: 617 GQFSTKKNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQTKHMKKYPKRPDWNINKPPK 676
Q + +++L Q + A EK + TR++ + + +++ + + +
Sbjct: 2280 RQLA----EEDLAQQR-ALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL----AQEQAR 2330
Query: 677 RYIPASEKYPKQLQKQRE------EKKVRRQMELLHLVE--KNNPGHLSQNRGISPE--- 725
R E+ +QL ++ + E + +RQ+E+ E K +S+ + + E
Sbjct: 2331 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2390
Query: 726 IFHSSHQETESKL-RWHLVKKEEEPL----------NIHSFSKERSPSSPVPVVKNRTQQ 774
F +E KL R L +E+ L + H + R + + K + QQ
Sbjct: 2391 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2450
Query: 775 TQNTLHLPLKNSSYERENLISGSNQTELSSGISESSHFIPYVRTNE-----IYYLDPDAP 829
L L + ++ + Q S +SE + R E + L D
Sbjct: 2451 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2510
Query: 830 LSGPSTQDPQYQNSQDCGQKRQLFDSDCVRDPLLNPNMVKNRDRQQAILKGLSELRQGLL 889
++ Q + Q Q+RQ L +M + R RQ E +G+
Sbjct: 2511 AKAQQLREEQQRQQQQMEQERQ----------RLVASMEEARRRQH-------EAEEGVR 2553
Query: 890 QKQKELE 896
+KQ+EL+
Sbjct: 2554 RKQEELQ 2560
Score = 42.7 bits (99), Expect = 0.002
Identities = 65/312 (20%), Positives = 128/312 (41%), Gaps = 64/312 (20%)
Query: 191 QETSKQCEQKIAIENEWKPADIFSTLGER-----ECDRSSL---EAKKAQWRKELDEQVA 242
QE +Q Q++A E + + + + E +R L E +AQ R E D Q
Sbjct: 2333 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ-R 2391
Query: 243 LKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEEL 302
+K+ +E+ EK + ++ EK ++ +T+ ++ S E R+ I EL
Sbjct: 2392 FRKQAEEIGEKLH------RTELATQEKVTLV----QTLEIQRQQSDHDAERLREAIAEL 2441
Query: 303 NKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSP 362
++ E +Q E K++ K EE Q QL ++ Q +
Sbjct: 2442 EREKEKLQQ---EAKLLQLKSEEMQTV------------QQEQLLQETQALQQSFL---- 2482
Query: 363 DTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEE 422
SE++ + + + + +K + A Q+ E
Sbjct: 2483 ----------------------SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ--QLRE 2518
Query: 423 RDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDIL 482
+R+Q+Q+E ++ E+ R++Q E E+ + +QEE +L Q+R + ++ E+
Sbjct: 2519 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE-- 2576
Query: 483 KQKQKEEIMTLK 494
Q+ +E++ L+
Sbjct: 2577 NQRLREQLQLLE 2588
Score = 37.0 bits (84), Expect = 0.084
Identities = 44/171 (25%), Positives = 78/171 (45%), Gaps = 14/171 (8%)
Query: 366 ELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQ-IEERD 424
E V ++ P+ + SE E ++ V ++ L++++ ++ Q EE
Sbjct: 1032 EAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVL 1091
Query: 425 RRRQKQLEHQKAITAQVEE--------KRRKKQLEEEQRKKEEQEEELRLAQEREE--MQ 474
R ++QL+ +A+ A + E K+ + Q E +Q + +ELR AQE E Q
Sbjct: 1092 RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQ 1151
Query: 475 KQYEEDILKQKQKEEIMTLKTN---ELFQTMQRAQELAQRLKQEQRIRELA 522
+ E D+ ++ +E + L L QT R +EL Q +Q + RE A
Sbjct: 1152 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1202
Score = 33.1 bits (74), Expect = 1.2
Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 31/137 (22%)
Query: 425 RRRQKQLEHQKAITAQ-VEEKRRKKQ--LEEEQRKKEEQEEELRLAQEREEMQKQYEEDI 481
RRRQ+Q++ +Q V E+ R++Q LEE +R E+ EE R A++ K YE +
Sbjct: 1213 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL 1272
Query: 482 LKQKQK---------------------EEIMTLKTNELFQTMQRAQ------ELAQRLKQ 514
+ K + +E + L+T+ T +Q E +R+++
Sbjct: 1273 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1332
Query: 515 EQRIRELAQKGHDTSRL 531
E+R+ E Q+ + RL
Sbjct: 1333 EERLAE-QQRAEERERL 1348
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 63.2 bits (152), Expect = 1e-09
Identities = 99/455 (21%), Positives = 187/455 (41%), Gaps = 43/455 (9%)
Query: 74 QKEISPATPNMQKTRNTVNTSLVGKQKPH--KKHITAENMKSSLVCLTQDQLQQILMTVN 131
QK ++ A QK GK + ++ AE L + QQ L
Sbjct: 1681 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1740
Query: 132 QGNRSLSLTENGKEAKSQYSLYLNSI------SNQPKDENIMGLFKKTEMVSSVPAENKS 185
+ R + TE G++ + L + + Q + E L K + + A
Sbjct: 1741 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1800
Query: 186 VLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQVALKK 245
E + TS++ +Q++ E A F L E E R A++A+ +++L E+ A ++
Sbjct: 1801 AEEESRSTSEKSKQRLEAE-----AGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQ 1854
Query: 246 KEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEELNKQ 305
+ +E+++++ EK + ++ T L A+K++ E L +
Sbjct: 1855 R--------------AEAERVLAEKLAAIGEA--TRLKTEAEIALKEKEAEN--ERLRRL 1896
Query: 306 IEDD--RQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSPD 363
ED+ ++R++EE+ K + +R A + S Q L + ++ + +
Sbjct: 1897 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV-----E 1951
Query: 364 TQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEER 423
+ LA +S G E I +D + SK+ L + A EE
Sbjct: 1952 EEILALKASFEKAAAGKAELELELGRIRSNAEDTL--RSKEQAELEA--ARQRQLAAEEE 2007
Query: 424 DRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILK 483
RRR+ + QK++ A+ E R++K EE + + + EE R +ER E + + + +
Sbjct: 2008 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2067
Query: 484 QKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRI 518
+ ++ + + F Q+ QEL Q L+QEQ +
Sbjct: 2068 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2102
Score = 60.5 bits (145), Expect = 7e-09
Identities = 116/633 (18%), Positives = 260/633 (41%), Gaps = 87/633 (13%)
Query: 123 LQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLF--KKTEMVSSVP 180
L+++ + + R L E + + Q +L S + + ++ F K ++ S+
Sbjct: 1565 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1624
Query: 181 AENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQ 240
E+ +V +E ++ +Q+ E + A ERE +R W+ + +E
Sbjct: 1625 EEHVAVAQLREEAERRAQQQAEAERAREEA-------ERELER---------WQLKANEA 1668
Query: 241 VALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQ-ELQRKWI 299
+ L+ + +EV+++ ++E++K +K + ++R E AV+Q EL + +
Sbjct: 1669 LRLRLQAEEVAQQ--KSLAQAEAEK---QKEEAEREARRRGKAEE--QAVRQRELAEQEL 1721
Query: 300 EELNKQIEDDRQRKI--EEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEY 357
E+ + E Q+++ E+++I + E G Q + +
Sbjct: 1722 EKQRQLAEGTAQQRLAAEQELIRLRAETEQ-------------GEQQRQLLE-------- 1760
Query: 358 FCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDP 417
+ELA + T + E E + +V++A+ + T+
Sbjct: 1761 -------EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1813
Query: 418 AQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQE----REEM 473
++E R ++ E + A EE +R++QL EE ++ E E LA++ E
Sbjct: 1814 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1873
Query: 474 QKQYEEDIL---KQKQKEEIMTLKTNELFQTMQRAQELAQ-RLKQEQRIRELAQKGHDTS 529
+ + E +I K+ + E + L +E FQ + ++ AQ + E+R+ +L +
Sbjct: 1874 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1933
Query: 530 RLIKNLGVDTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIG-IF 588
K L DT++ R +EI ++ + K + +L +G I
Sbjct: 1934 ERQKGLVEDTLRQR---------RQVEEEILALKASFEKAAAGKAEL-----ELELGRIR 1979
Query: 589 TNAESHCGSLMERDITNCSSPEISAELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCN 648
+NAE S + ++ +++AE + ++ +E Q A+ E+ +
Sbjct: 1980 SNAEDTLRSKEQAELEAARQRQLAAE---EERRRREAEERVQKSLAAEEEAARQRKAALE 2036
Query: 649 QFTRIEKQTKHMKKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEK--KVRRQMELLH 706
+ R++ + + ++ +R + + ++ A E K+LQ + + V+++ + L
Sbjct: 2037 EVERLKAKVEEARRLRERAE---QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2093
Query: 707 LVEKNNPGHLSQNRGISPEIFHSSHQETESKLR 739
+ L Q RG + ++ + E++++
Sbjct: 2094 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2126
Score = 58.2 bits (139), Expect = 4e-08
Identities = 77/391 (19%), Positives = 166/391 (42%), Gaps = 46/391 (11%)
Query: 179 VPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELD 238
V + ++SV+ E+ + + + +++ I TL E + E ++A+ R+ L
Sbjct: 1332 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKF-ISETLRRMEEEERLAEQQRAEERERLA 1390
Query: 239 EQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKW 298
E A +K+++++E ++E + + L Q + ++ +AV + Q++
Sbjct: 1391 EVEAALEKQRQLAEAHAQAKAQAEREA------KELQQRMQEEVVRREEAAVDAQQQKRS 1444
Query: 299 IEELNKQIEDDRQRKIEEKIIYSKGEEHDRWA---------MHFDSLKSYPGSQSQLFSQ 349
I+E +Q+ + +I+ K ++ E R + ++ + G
Sbjct: 1445 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1504
Query: 350 STHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLR 409
+ E QE A+ + +E E +A +K A +K L+
Sbjct: 1505 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE-LASRVKAEAEAAREKQRALQ 1563
Query: 410 SMTALLDPAQIEERDRR-RQKQLEH-----------QKAITAQVEEKRRKKQLEEEQRKK 457
++ L Q EE +RR RQ ++E Q++ A+++ KR + Q ++
Sbjct: 1564 ALEELR--LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1621
Query: 458 EEQEEELRLAQEREEMQKQYEEDILKQKQKEEI------MTLKTNELFQTMQRAQELAQR 511
QEE + +AQ REE +++ ++ ++ +EE LK NE + +A+E+AQ+
Sbjct: 1622 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1681
Query: 512 ---------LKQEQRIRELAQKGHDTSRLIK 533
++E+ RE ++G + ++
Sbjct: 1682 KSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1712
Score = 57.8 bits (138), Expect = 5e-08
Identities = 77/380 (20%), Positives = 174/380 (45%), Gaps = 50/380 (13%)
Query: 173 TEMVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQ 232
+++ + + AEN++++ ++ +++ Q+ A+ + E E R S+ A++A
Sbjct: 2268 SKLKARIEAENRALILRDKDNTQRFLQE--------EAEKMKQVAE-EAARLSVAAQEAA 2318
Query: 233 WRKELDEQVALKKK---EKEVSEKWNDPWK----KSESDKIIWEKHQILDQSRETVLLEH 285
++L E+ +++ EK + EK + K+E++ + +K +Q+R L+
Sbjct: 2319 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR---LQE 2375
Query: 286 PFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQ 345
+ Q+L + + + +E +RQR++E E +R + + S ++++
Sbjct: 2376 DKEQMAQQLAEE-TQGFQRTLEAERQRQLE------MSAEAERLKLRVAEM-SRAQARAE 2427
Query: 346 LFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKT 405
+Q KQ E ELA V T +++ + +H A+ +++ + ++
Sbjct: 2428 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREK 2486
Query: 406 NFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQV---------------EEKRRKKQL 450
L+ LL E + ++++ L+ +A+ +EK + +QL
Sbjct: 2487 EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2546
Query: 451 ------EEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQR 504
+ +Q ++E+Q ++ ++ QER+ + EE +Q + EE + K EL Q Q+
Sbjct: 2547 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2606
Query: 505 AQELAQRLKQE-QRIRELAQ 523
++ + L +E QR+RE Q
Sbjct: 2607 RRQQEELLAEENQRLREQLQ 2626
Score = 52.8 bits (125), Expect = 1e-06
Identities = 166/907 (18%), Positives = 336/907 (37%), Gaps = 134/907 (14%)
Query: 63 KQCIDKDCLHIQKEISPATPNMQ-------KTRNTVNTSLVGKQKPHKK-HITAENMKSS 114
+Q ++++ +Q+E + AT Q K R + L K + ++ T+E K
Sbjct: 1756 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1815
Query: 115 LVCLTQDQLQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTE 174
L + + + + R +L E EAK Q L + Q +
Sbjct: 1816 L----EAEAGRFRELAEEAARLRALAE---EAKRQRQLAEEDAARQRAE----------- 1857
Query: 175 MVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGEREC-DRSSLEAKKAQW 233
V AE + + E T + E +IA++ + + L E E R LE + AQ
Sbjct: 1858 -AERVLAEKLAAIGE--ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1914
Query: 234 RKELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQE 293
+ +++E++A +K + SE ++ +K + D R+ +E A+K
Sbjct: 1915 KADIEERLAQLRKASD-----------SELER---QKGLVEDTLRQRRQVEEEILALKAS 1960
Query: 294 LQRKWIEELNKQIEDDRQRKIEEKIIYSK--------------GEEHDRWAMHFDSLKSY 339
++ + ++E R R E + SK EE R + ++
Sbjct: 1961 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 2020
Query: 340 PGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEE---EHIAKPIKD 396
++ + Q E + +E + + Q++ ++E + + K
Sbjct: 2021 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2080
Query: 397 VVMANSKKTNFLRSMT----ALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEE 452
A +K L+ ++LD + E RR + + + A+ E + ++Q+EE
Sbjct: 2081 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2140
Query: 453 EQRKKEEQEEELRLAQE----REEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQR---- 504
+R K+ EE+ + + E+++K+ E++ ++ Q E+ + M++
Sbjct: 2141 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF 2200
Query: 505 -AQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDEISGKM 563
Q L Q+ + EQ + L + +T L + +++ A+ + R +E +
Sbjct: 2201 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2260
Query: 564 NTYMNSTTSKK-------DTGVQTDDLNIGIFTNAESHCGSLMERDITNCSSPEISAELI 616
M + K + D N F E+ + + S A +
Sbjct: 2261 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2320
Query: 617 GQFSTKKNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQTKHMKKYPKRPDWNINKPPK 676
Q + +++L Q + A EK + TR++ + + +++ + + +
Sbjct: 2321 RQLA----EEDLAQQR-ALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL----AQEQAR 2371
Query: 677 RYIPASEKYPKQLQKQRE------EKKVRRQMELLHLVE--KNNPGHLSQNRGISPE--- 725
R E+ +QL ++ + E + +RQ+E+ E K +S+ + + E
Sbjct: 2372 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2431
Query: 726 IFHSSHQETESKL-RWHLVKKEEEPL----------NIHSFSKERSPSSPVPVVKNRTQQ 774
F +E KL R L +E+ L + H + R + + K + QQ
Sbjct: 2432 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2491
Query: 775 TQNTLHLPLKNSSYERENLISGSNQTELSSGISESSHFIPYVRTNE-----IYYLDPDAP 829
L L + ++ + Q S +SE + R E + L D
Sbjct: 2492 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2551
Query: 830 LSGPSTQDPQYQNSQDCGQKRQLFDSDCVRDPLLNPNMVKNRDRQQAILKGLSELRQGLL 889
++ Q + Q Q+RQ L +M + R RQ E +G+
Sbjct: 2552 AKAQQLREEQQRQQQQMEQERQ----------RLVASMEEARRRQH-------EAEEGVR 2594
Query: 890 QKQKELE 896
+KQ+EL+
Sbjct: 2595 RKQEELQ 2601
Score = 42.7 bits (99), Expect = 0.002
Identities = 65/312 (20%), Positives = 128/312 (41%), Gaps = 64/312 (20%)
Query: 191 QETSKQCEQKIAIENEWKPADIFSTLGER-----ECDRSSL---EAKKAQWRKELDEQVA 242
QE +Q Q++A E + + + + E +R L E +AQ R E D Q
Sbjct: 2374 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ-R 2432
Query: 243 LKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEEL 302
+K+ +E+ EK + ++ EK ++ +T+ ++ S E R+ I EL
Sbjct: 2433 FRKQAEEIGEKLH------RTELATQEKVTLV----QTLEIQRQQSDHDAERLREAIAEL 2482
Query: 303 NKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSP 362
++ E +Q E K++ K EE Q QL ++ Q +
Sbjct: 2483 EREKEKLQQ---EAKLLQLKSEEMQTV------------QQEQLLQETQALQQSFL---- 2523
Query: 363 DTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEE 422
SE++ + + + + +K + A Q+ E
Sbjct: 2524 ----------------------SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ--QLRE 2559
Query: 423 RDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDIL 482
+R+Q+Q+E ++ E+ R++Q E E+ + +QEE +L Q+R + ++ E+
Sbjct: 2560 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE-- 2617
Query: 483 KQKQKEEIMTLK 494
Q+ +E++ L+
Sbjct: 2618 NQRLREQLQLLE 2629
Score = 37.0 bits (84), Expect = 0.084
Identities = 44/171 (25%), Positives = 78/171 (45%), Gaps = 14/171 (8%)
Query: 366 ELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQ-IEERD 424
E V ++ P+ + SE E ++ V ++ L++++ ++ Q EE
Sbjct: 1073 EAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVL 1132
Query: 425 RRRQKQLEHQKAITAQVEE--------KRRKKQLEEEQRKKEEQEEELRLAQEREE--MQ 474
R ++QL+ +A+ A + E K+ + Q E +Q + +ELR AQE E Q
Sbjct: 1133 RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQ 1192
Query: 475 KQYEEDILKQKQKEEIMTLKTN---ELFQTMQRAQELAQRLKQEQRIRELA 522
+ E D+ ++ +E + L L QT R +EL Q +Q + RE A
Sbjct: 1193 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1243
Score = 33.1 bits (74), Expect = 1.2
Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 31/137 (22%)
Query: 425 RRRQKQLEHQKAITAQ-VEEKRRKKQ--LEEEQRKKEEQEEELRLAQEREEMQKQYEEDI 481
RRRQ+Q++ +Q V E+ R++Q LEE +R E+ EE R A++ K YE +
Sbjct: 1254 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL 1313
Query: 482 LKQKQK---------------------EEIMTLKTNELFQTMQRAQ------ELAQRLKQ 514
+ K + +E + L+T+ T +Q E +R+++
Sbjct: 1314 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1373
Query: 515 EQRIRELAQKGHDTSRL 531
E+R+ E Q+ + RL
Sbjct: 1374 EERLAE-QQRAEERERL 1389
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 62.8 bits (151), Expect = 1e-09
Identities = 89/442 (20%), Positives = 200/442 (45%), Gaps = 59/442 (13%)
Query: 122 QLQQILMTV----NQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTEMVS 177
+L+Q L V + +R + ++A S LY N+I+++ E L +K ++V
Sbjct: 176 ELEQALSAVATQKKKADRYIEELTKERDALS-LELYRNTITDEELKEKNAKLQEKLQLVE 234
Query: 178 SVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQ---WR 234
S +E + LN + K K+ + + A+ E + + L+A+ + W
Sbjct: 235 SEKSEIQ--LNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWN 292
Query: 235 KELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQEL 294
+ +Q +++E ++W + K E ++ I E+ + + + E + + K+E
Sbjct: 293 RLNQQQEEKMWRQEEKIQEWEE--KIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEK 350
Query: 295 QRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQ 354
R+ E + ++ +++ R++EE +++ K E+ L+ Q ++ Q +Q
Sbjct: 351 MRRQEEMMWEK--EEKMRRLEE-MMWEKEEK-------IRELEEKMHEQEKIREQEEKRQ 400
Query: 355 PEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTAL 414
E + ++ + + +E + ++ + KK R +
Sbjct: 401 EEEKIREQEKRQ------------EQEAKMWRQEEKIREQEEKIREQEKK--MWRQEEKI 446
Query: 415 LDPAQIEERDRRRQKQ--LEHQKAITAQVEEKRRKKQLEEEQ--RKKEE----------- 459
+ +I E ++R++++ ++ I Q E R+K+++ E++ RK+EE
Sbjct: 447 HEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHD 506
Query: 460 QEEELRLAQER----EEMQKQYEEDILKQKQK----EEIMTLKTNELFQTMQRAQELAQR 511
QEE++R +E+ EE ++ EE I +Q++K EE+M + ++ + ++ QE +
Sbjct: 507 QEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKM 566
Query: 512 LKQEQRIRELAQKGHDTSRLIK 533
+QE++IRE +K + I+
Sbjct: 567 RRQEEKIREQEEKIREQKEKIR 588
Score = 61.2 bits (147), Expect = 4e-09
Identities = 95/483 (19%), Positives = 208/483 (43%), Gaps = 73/483 (15%)
Query: 83 NMQKTRNTVNTSLVGKQ--KPHKKHITAENMKSSLVCLTQD---QLQQILMTVNQGNRSL 137
+++ RNT+ + ++ K +K E+ KS + ++ +L++ + + Q
Sbjct: 206 SLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQA 265
Query: 138 SLTENGKE-----AKSQYSLYLNSI---SNQPKDENIMGLFKKTEMVSSVPAENKSVLNE 189
GKE AK Q + N + NQ ++E + +K + E + + E
Sbjct: 266 EADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE 325
Query: 190 HQETSKQCEQKIAIENE--WKPADIFSTLGER--ECDRSSLEAKKAQWRKE--------- 236
+E ++ E+K+ + E W+ + E E + ++ W KE
Sbjct: 326 QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEK 385
Query: 237 LDEQVALKKKE--KEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLE---------- 284
+ EQ ++++E ++ EK + K+ E + +W + + + + E + +
Sbjct: 386 MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEK 445
Query: 285 -HPFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQ 343
H +++E +R+ EE+ +Q E R+ +E+I K + H++ + K + +
Sbjct: 446 IHEQEKIREEEKRQEQEEMWRQEEKIRE---QEEIWRQKEKMHEQEKIRKQEEKVWRQEE 502
Query: 344 SQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSK 403
+ ++ E + + + E+E + ++++ +
Sbjct: 503 KMHDQEEKIREQEEKMWRQEEKIREQEEKI-----------REQEEKIREQEEMMQEQEE 551
Query: 404 KTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRR--KKQLEEEQRKKEEQE 461
K M + Q +E+ RR+++++ Q EEK R K+++ E++ K EQE
Sbjct: 552 K------MGEQEEKMQEQEKMRRQEEKIREQ-------EEKIREQKEKIREQEEKIWEQE 598
Query: 462 EELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIREL 521
E++R E+EEM ++ EE + +Q++K K E + M+R +E + +QE R+R+
Sbjct: 599 EKIR---EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE--KMWEQEVRLRQQ 653
Query: 522 AQK 524
+K
Sbjct: 654 EEK 656
Score = 54.7 bits (130), Expect = 4e-07
Identities = 68/338 (20%), Positives = 149/338 (44%), Gaps = 64/338 (18%)
Query: 162 KDENIMGLFKKTEMVSSVPAENKSVLNEHQETSKQCEQKIAIENE---WKPADIFSTLGE 218
K+E I L +K + + + + QE K EQ+ E E W+ +
Sbjct: 375 KEEKIRELEEKMHEQEKIREQEE----KRQEEEKIREQEKRQEQEAKMWRQEEKI----- 425
Query: 219 RECDRSSLEAKKAQWRKE--LDEQVALKKKEK--EVSEKWNDPWKKSESDKIIWEKHQIL 274
RE + E +K WR+E + EQ ++++EK E E W K E ++I +K ++
Sbjct: 426 REQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMH 485
Query: 275 DQSRETVLLEHPFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFD 334
+Q + ++++ ++ W +E ++++ R+ EEK+ + EE R
Sbjct: 486 EQEK-----------IRKQEEKVWRQEEKMHDQEEKIREQEEKMW--RQEEKIR------ 526
Query: 335 SLKSYPGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPI 394
Q + + K E + + +E G Q E +E+ +
Sbjct: 527 -------EQEEKIREQEEKIREQEEMMQEQEE----------KMGEQEEKMQEQEKMRRQ 569
Query: 395 KDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEK--RRKKQLEE 452
++ + +K + + EE+ +++++ Q+ + + EEK +++++ E
Sbjct: 570 EEKIREQEEKIREQKEKIR-----EQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCE 624
Query: 453 EQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEI 490
++ K +EQEE++R +E K +E+++ ++Q+E++
Sbjct: 625 QEEKMQEQEEKMRRQEE-----KMWEQEVRLRQQEEKM 657
Score = 42.0 bits (97), Expect = 0.003
Identities = 57/292 (19%), Positives = 126/292 (43%), Gaps = 26/292 (8%)
Query: 419 QIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYE 478
+++E++ + Q++L+ VE ++ + QL ++ K++ + +L L Q++ + + +
Sbjct: 218 ELKEKNAKLQEKLQ-------LVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHL 270
Query: 479 EDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVD 538
L+ + ++ NEL+ + + QE + +QE++I+E +K + I+
Sbjct: 271 GKELQSVSAKLQAQVEENELWNRLNQQQE-EKMWRQEEKIQEWEEKIQEQEEKIREQEEK 329
Query: 539 TIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCGSL 598
+ E + +E KM K++ + +++ E L
Sbjct: 330 IREQEEKMRRQEEMMWEKEE---KMRRQEEMMWEKEEKMRRLEEM----MWEKEEKIREL 382
Query: 599 MERDITNCSSPEISAELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQTK 658
E+ E E Q K +QE Q++ A + ++ + +Q E++ +
Sbjct: 383 EEKMHEQEKIRE--QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ-------EEKIR 433
Query: 659 HMKKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEKKVRRQMELLHLVEK 710
+K R + I++ K I EK +Q + R+E+K+R Q E+ EK
Sbjct: 434 EQEKKMWRQEEKIHEQEK--IREEEKRQEQEEMWRQEEKIREQEEIWRQKEK 483
>gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens]
Length = 495
Score = 62.0 bits (149), Expect = 2e-09
Identities = 81/408 (19%), Positives = 176/408 (43%), Gaps = 55/408 (13%)
Query: 141 ENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTEMVSSVPAENKSVLNEHQETSKQCEQK 200
E+ K+ K + + NSI + ++ + + E + + AE ++ E + + +
Sbjct: 103 ESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQI-AEKDAIKYEQMKRDAEIAKT 161
Query: 201 IAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQVALKKKEKEVSEKWNDPWKK 260
+ E++ + E KAQ+ +L++Q+ ++K+K+ + +++
Sbjct: 162 MMEEHK-------RIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQ------EAYEQ 208
Query: 261 SESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEELNKQIEDDRQRKIEE---- 316
+K++ + +I+ + E LE K R++IEE K+ R++K EE
Sbjct: 209 LLKEKLMID--EIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEE 266
Query: 317 --KIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSPDTQEL------- 367
KII + R ++ + QL + T K E D +++
Sbjct: 267 NRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQE 326
Query: 368 -------ADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVM--ANSKKTNFLRSMTALL--- 415
+ + Q E ++ +K++V+ A ++ NF ++M A
Sbjct: 327 EQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAED 386
Query: 416 DPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELR--------LA 467
D ++ ++R KQLEH++A+ +EE RR++ L ++QR+ EE + + R +
Sbjct: 387 DRIELMNAQKQRMKQLEHRRAVEKLIEE-RRQQFLADKQRELEEWQLQQRRQGFINAIIE 445
Query: 468 QEREEMQKQYEEDILKQK-----QKEEIMTLKTNELFQTMQRAQELAQ 510
+ER ++ K++ ++L +KE+ + L E + Q+ E+ +
Sbjct: 446 EERLKLLKEHATNLLGYLPKGVFKKEDDIDLLGEEFRKVYQQRSEICE 493
Score = 49.3 bits (116), Expect = 2e-05
Identities = 32/105 (30%), Positives = 57/105 (54%), Gaps = 9/105 (8%)
Query: 421 EERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEED 480
EE +Q++LE A+ +EE ++++ L + +K+EE EEE R E MQ+Q EED
Sbjct: 225 EEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRK-KKREEMEEENRKIIEFANMQQQREED 283
Query: 481 IL--------KQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQR 517
+ K+ Q + +T K E+ + + +++ Q L QE++
Sbjct: 284 RMAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQ 328
Score = 39.7 bits (91), Expect = 0.013
Identities = 88/458 (19%), Positives = 200/458 (43%), Gaps = 77/458 (16%)
Query: 125 QILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTEMVSSVPAENK 184
Q L VN R+ + +N + + Q +L + N+ + ++ +K E ENK
Sbjct: 29 QALKNVNSQIRN-QMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAE-------ENK 80
Query: 185 SVLNEHQETSKQCEQKIAIE-NEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQVAL 243
+ +E + E+K+A+E + K + ++ +S+E ++ + K+L
Sbjct: 81 RL----KELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELE--KKLKAAYMN 134
Query: 244 KKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEELN 303
K++ +++EK +++ + D I + ++++ + + E+ + + + ++ +L
Sbjct: 135 KERAAQIAEKDAIKYEQMKRDAEIAKT--MMEEHKRIIKEENAAEDKRNKAKAQYYLDLE 192
Query: 304 KQIEDDRQRKIE--EKIIYSKG--EEHDRWAMHFDSLKSYPGSQSQLFSQSTHK------ 353
KQ+E+ ++K E E+++ K +E R D L+ Q +L + +
Sbjct: 193 KQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEK----QQKLEKMNAMRRYIEEF 248
Query: 354 QPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTA 413
Q E +E + + + + EE+ +AK V K+ ++T
Sbjct: 249 QKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAK----VQENEEKRLQLQNALTQ 304
Query: 414 LLDPA--QIEERDRRRQKQLEHQKA------ITAQVEEK-RRKKQLEEE----------- 453
L+ Q E+ ++ RQ+ + ++A + + E+K R++K+++++
Sbjct: 305 KLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELV 364
Query: 454 -QRKKEEQE-------------EELRLAQEREEMQKQYEE----DILKQKQKEEIMTLKT 495
Q KEE+E + + L +++ KQ E + L ++++++ + K
Sbjct: 365 LQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQ 424
Query: 496 NEL--FQTMQRAQELAQRLKQEQRIRELAQKGHDTSRL 531
EL +Q QR Q + +E+R++ L K H T+ L
Sbjct: 425 RELEEWQLQQRRQGFINAIIEEERLKLL--KEHATNLL 460
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 61.6 bits (148), Expect = 3e-09
Identities = 37/103 (35%), Positives = 65/103 (63%), Gaps = 10/103 (9%)
Query: 421 EERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEED 480
+ R+ + QKQLE AQ+E +++K+++ E+++++ E+E+E E E KQ EE
Sbjct: 308 QAREEKHQKQLER-----AQLENEKKKREIAEKEKERIEREKE-----ELMERLKQIEEQ 357
Query: 481 ILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQ 523
+K +++ E T K EL Q +RA+E A+RL++E+R E A+
Sbjct: 358 TIKAQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAK 400
Score = 42.4 bits (98), Expect = 0.002
Identities = 59/305 (19%), Positives = 136/305 (44%), Gaps = 43/305 (14%)
Query: 220 ECDRSSLEAKKAQWRKELDE-QVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSR 278
E + +A++ + +K+L+ Q+ +KK++E++EK E ++I EK +++++ +
Sbjct: 301 EVQQMKAQAREEKHQKQLERAQLENEKKKREIAEK--------EKERIEREKEELMERLK 352
Query: 279 ETVLLEHPFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKS 338
+ +E ++EL+ E+ K +E D++RK + EE +R + +
Sbjct: 353 Q---IEEQTIKAQKELE----EQTRKALELDQERKRAK-------EEAERLEKERRAAEE 398
Query: 339 YPGSQSQLFSQSTHKQPEYFCVSPDTQEL-ADVSSVCTPTTGSQVEPSEEEHIAKPIKDV 397
++S + Q+ + ++ + E A ++ + + E +E +H A ++
Sbjct: 399 ---AKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQED 455
Query: 398 VMANSKKTNFLRSMTALLDPAQI-----------EERDRRRQKQLEHQKAITAQVEEKRR 446
+ ++ + S P + +E + +L ++ + + EE+R
Sbjct: 456 LEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEHDENNAEASAELSNEGVMNHRSEEERV 515
Query: 447 KKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQ----KEEIMTLKTNELFQTM 502
+ + E+ KK+ Q LAQ R+E +K + D+L + +++ TL+ T
Sbjct: 516 TETQKNERVKKQLQALSSELAQARDETKKT-QNDVLHAENVKAGRDKYKTLRQIRQGNTK 574
Query: 503 QRAQE 507
QR E
Sbjct: 575 QRIDE 579
Score = 40.0 bits (92), Expect = 0.010
Identities = 44/171 (25%), Positives = 82/171 (47%), Gaps = 22/171 (12%)
Query: 362 PDTQELADVSSVCTPTTGS-QVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPA-Q 419
PDT E+ + + Q+E ++ E+ K + +A +K R L++ Q
Sbjct: 297 PDTIEVQQMKAQAREEKHQKQLERAQLENEKKKRE---IAEKEKERIEREKEELMERLKQ 353
Query: 420 IEERDRRRQKQLEHQ--KAITAQVEEKRRKKQ---LEEEQRKKEEQEEEL-RLAQEREEM 473
IEE+ + QK+LE Q KA+ E KR K++ LE+E+R EE + + + A ++ +
Sbjct: 354 IEEQTIKAQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKN 413
Query: 474 QKQYEEDILK-----------QKQKEEIMTLKTNELFQTMQRAQELAQRLK 513
Q+Q ++ + +K+KEE T ++ F + ++ + LK
Sbjct: 414 QEQLAAELAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELK 464
Score = 37.4 bits (85), Expect = 0.064
Identities = 35/147 (23%), Positives = 70/147 (47%), Gaps = 18/147 (12%)
Query: 381 QVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRR-QKQLEHQKAITA 439
+ + EE+H K ++ + N KK +I E+++ R +++ E
Sbjct: 306 KAQAREEKH-QKQLERAQLENEKKKR------------EIAEKEKERIEREKEELMERLK 352
Query: 440 QVEEK--RRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNE 497
Q+EE+ + +K+LEE+ RK E ++E + A +EE ++ +E ++ K I ++
Sbjct: 353 QIEEQTIKAQKELEEQTRKALELDQERKRA--KEEAERLEKERRAAEEAKSAIAKQAADQ 410
Query: 498 LFQTMQRAQELAQRLKQEQRIRELAQK 524
+ Q A ELA+ + + E +K
Sbjct: 411 MKNQEQLAAELAEFTAKIALLEEAKKK 437
Score = 34.7 bits (78), Expect = 0.42
Identities = 27/116 (23%), Positives = 55/116 (47%), Gaps = 12/116 (10%)
Query: 444 KRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQ 503
+R+ +E +Q K + +EE+ + ER +++ + ++ + +K+KE I K
Sbjct: 294 RRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREK--------- 344
Query: 504 RAQELAQRLKQEQRIRELAQKG-HDTSRLIKNLGVDTIQMEYNASNISNSRHDSDE 558
+EL +RLKQ + AQK + +R L + + + A + R ++E
Sbjct: 345 --EELMERLKQIEEQTIKAQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEE 398
>gi|41152097 DNA segment on chromosome X and Y (unique) 155
expressed sequence isoform 1 [Homo sapiens]
Length = 695
Score = 61.2 bits (147), Expect = 4e-09
Identities = 45/129 (34%), Positives = 73/129 (56%), Gaps = 14/129 (10%)
Query: 412 TALLDPAQIEERDRRRQK--QLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQE 469
T L A I++R RQK +LE Q+ E+KRR+K+ EE QR +E +++EL E
Sbjct: 260 TKHLSDASIKKRQLERQKLQELEQQRE-----EQKRREKEAEERQRAEERKQKEL----E 310
Query: 470 REEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQE---LAQRLKQEQRIRELAQKGH 526
E +++ EE + K++QK+ L+ N+ +A+E L +++K E+R LAQ+
Sbjct: 311 ELERERKREEKLRKREQKQRDRELRRNQKKLEKLQAEEQKQLQEKIKLEERKLLLAQRNL 370
Query: 527 DTSRLIKNL 535
+ RLI L
Sbjct: 371 QSIRLIAEL 379
Score = 46.6 bits (109), Expect = 1e-04
Identities = 41/159 (25%), Positives = 81/159 (50%), Gaps = 19/159 (11%)
Query: 400 ANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITA---QVEEKRRKKQLEEEQRK 456
A+ KK R L+ Q EE+ RR ++ E Q+A ++EE R+++ EE+ RK
Sbjct: 266 ASIKKRQLERQKLQELEQ-QREEQKRREKEAEERQRAEERKQKELEELERERKREEKLRK 324
Query: 457 KEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNEL------FQTMQRAQELAQ 510
+E+++ + L + +++++K E+ QKQ +E + L+ +L Q+++ EL
Sbjct: 325 REQKQRDRELRRNQKKLEKLQAEE---QKQLQEKIKLEERKLLLAQRNLQSIRLIAELLS 381
Query: 511 RLK------QEQRIRELAQKGHDTSRLIKNLGVDTIQME 543
R K QEQ+ +L + + R ++ + ++ E
Sbjct: 382 RAKAVKLREQEQKEEKLRLQQQEERRRLQEAELRRVEEE 420
Score = 39.7 bits (91), Expect = 0.013
Identities = 34/116 (29%), Positives = 60/116 (51%), Gaps = 19/116 (16%)
Query: 422 ERDRRRQKQLEHQKAITAQVEEKRRKKQLE----EEQRKKEE----QEEELRLAQER--- 470
ER+R+R+++L ++ E +R +K+LE EEQ++ +E +E +L LAQ
Sbjct: 313 ERERKREEKLRKREQKQRDRELRRNQKKLEKLQAEEQKQLQEKIKLEERKLLLAQRNLQS 372
Query: 471 -----EEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIREL 521
E + + + +Q+QKEE + L+ E +R QE R +E++ R L
Sbjct: 373 IRLIAELLSRAKAVKLREQEQKEEKLRLQQQE---ERRRLQEAELRRVEEEKERAL 425
Score = 38.1 bits (87), Expect = 0.038
Identities = 39/201 (19%), Positives = 91/201 (45%), Gaps = 24/201 (11%)
Query: 288 SAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLF 347
S K++L+R+ ++EL +Q E+ ++R EK + +R + L+ + +L
Sbjct: 267 SIKKRQLERQKLQELEQQREEQKRR---EKEAEERQRAEERKQKELEELERERKREEKLR 323
Query: 348 SQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIK---DVVMANSKK 404
+ ++ + E +++ E++ + + IK ++ +
Sbjct: 324 KREQKQRDRELRRNQKKLE--------------KLQAEEQKQLQEKIKLEERKLLLAQRN 369
Query: 405 TNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEEL 464
+R + LL A+ + + QK+ + + Q +E+RR+ Q E +R +EE+E L
Sbjct: 370 LQSIRLIAELLSRAKAVKLREQEQKE----EKLRLQQQEERRRLQEAELRRVEEEKERAL 425
Query: 465 RLAQEREEMQKQYEEDILKQK 485
L ++ E++++ +L +K
Sbjct: 426 GLQRKERELRERLLSILLSKK 446
Score = 37.7 bits (86), Expect = 0.049
Identities = 41/140 (29%), Positives = 66/140 (47%), Gaps = 25/140 (17%)
Query: 408 LRSMTALLDPAQIEERDRRRQK-QLEHQKAITAQ---------VEEKRRKKQLEEEQRKK 457
LR L+ Q EE+ + ++K +LE +K + AQ E R K ++ R++
Sbjct: 334 LRRNQKKLEKLQAEEQKQLQEKIKLEERKLLLAQRNLQSIRLIAELLSRAKAVK--LREQ 391
Query: 458 EEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQR 517
E++EE+LRL Q+ E + Q E +++KE + L+ E +EL +RL
Sbjct: 392 EQKEEKLRLQQQEERRRLQEAELRRVEEEKERALGLQRKE--------RELRERL----- 438
Query: 518 IRELAQKGHDTSRLIKNLGV 537
+ L K D S LGV
Sbjct: 439 LSILLSKKPDDSHTHDELGV 458
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 60.8 bits (146), Expect = 5e-09
Identities = 39/125 (31%), Positives = 69/125 (55%), Gaps = 4/125 (3%)
Query: 401 NSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQ 460
N +++ LR L + E+ + +RQ E QK I Q E++RR LEE+QR++ E
Sbjct: 363 NKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR---LEEQQRREREA 419
Query: 461 EEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQR-LKQEQRIR 519
+ Q R E +++ + L++++KEE + E + ++R QE +R L++EQR
Sbjct: 420 RRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHL 479
Query: 520 ELAQK 524
E+ Q+
Sbjct: 480 EVLQQ 484
Score = 51.2 bits (121), Expect = 4e-06
Identities = 54/239 (22%), Positives = 110/239 (46%), Gaps = 25/239 (10%)
Query: 282 LLEHPFSAVKQELQRKWIEELNKQIEDDRQR---KIEEKIIYSKGEEHDRWAMHFDSLKS 338
LL+HPF Q +R+ +L I+ R++ K E + YS EE + +
Sbjct: 283 LLKHPFIR-DQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEE---EVPEQEG 338
Query: 339 YPGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVV 398
P S + +ST ++ ++ + + +E ++ Q+ EE + ++
Sbjct: 339 EPSSIVNVPGESTLRR-DFLRLQQENKERSEALRRQQLLQEQQLREQEEYK-----RQLL 392
Query: 399 MANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKE 458
K+ + L+ Q ER+ RRQ++ E ++ E+ K++LEE +R+++
Sbjct: 393 AERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRR------REQEEKRRLEELERRRK 446
Query: 459 EQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQR 517
E+EE R +E+ +++ E++ ++++ +EE L+ + Q QE A L +R
Sbjct: 447 EEEERRRAEEEKRRVER--EQEYIRRQLEEEQRHLEVLQ----QQLLQEQAMLLHDHRR 499
Score = 33.9 bits (76), Expect = 0.71
Identities = 36/157 (22%), Positives = 63/157 (40%), Gaps = 42/157 (26%)
Query: 410 SMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEE------ 463
S LL I ++ RQ +++ + I +++ K + E E EE+EEE
Sbjct: 279 STEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEG 338
Query: 464 ------------------LRLAQEREEM-----------------QKQYEEDILKQKQKE 488
LRL QE +E Q++Y+ +L ++QK
Sbjct: 339 EPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKR 398
Query: 489 -EIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQK 524
E + L + +R +E ++ ++EQR RE +K
Sbjct: 399 IEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEK 435
Score = 31.2 bits (69), Expect = 4.6
Identities = 29/129 (22%), Positives = 61/129 (47%), Gaps = 13/129 (10%)
Query: 189 EHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQVALKKKEK 248
E++ + + E++ E E +P+ I + GE R L + Q KE E + ++ +
Sbjct: 320 EYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ--QENKERSEALRRQQLLQ 377
Query: 249 EVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEELNKQIED 308
E + + +K+ +++ E+ + ++Q +E +E QR+ E +Q +
Sbjct: 378 EQQLREQEEYKR----QLLAERQKRIEQQKEQ-------RRRLEEQQRREREARRQQERE 426
Query: 309 DRQRKIEEK 317
R+R+ EEK
Sbjct: 427 QRRREQEEK 435
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.125 0.346
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,509,231
Number of Sequences: 37866
Number of extensions: 1747267
Number of successful extensions: 34321
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 558
Number of HSP's successfully gapped in prelim test: 1075
Number of HSP's that attempted gapping in prelim test: 11347
Number of HSP's gapped (non-prelim): 9615
length of query: 914
length of database: 18,247,518
effective HSP length: 111
effective length of query: 803
effective length of database: 14,044,392
effective search space: 11277646776
effective search space used: 11277646776
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.