BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta2 [Homo sapiens] (424 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta... 858 0.0 gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alph... 838 0.0 gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta... 770 0.0 gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alph... 750 0.0 gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo ... 733 0.0 gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo ... 733 0.0 gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alph... 717 0.0 gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta... 707 0.0 gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo s... 681 0.0 gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha... 666 0.0 gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta... 656 0.0 gi|20986508 mitogen-activated protein kinase 10 isoform 4 [Homo ... 493 e-139 gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gam... 447 e-126 gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ... 333 1e-91 gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens] 327 1e-89 gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens] 326 3e-89 gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo s... 324 1e-88 gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens] 315 4e-86 gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo ... 286 2e-77 gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo ... 276 3e-74 gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens] 266 3e-71 gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens] 266 3e-71 gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s... 263 2e-70 gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s... 258 7e-69 gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s... 255 5e-68 gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ... 255 5e-68 gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ... 255 5e-68 gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo ... 218 8e-57 gi|149408126 nemo like kinase [Homo sapiens] 211 1e-54 gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens] 198 9e-51 >gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta2 [Homo sapiens] Length = 424 Score = 858 bits (2216), Expect = 0.0 Identities = 424/424 (100%), Positives = 424/424 (100%) Query: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 Query: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240 Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300 Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360 Query: 361 MDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPL 420 MDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPL Sbjct: 361 MDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPL 420 Query: 421 EGCR 424 EGCR Sbjct: 421 EGCR 424 >gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alpha2 [Homo sapiens] Length = 424 Score = 838 bits (2164), Expect = 0.0 Identities = 415/424 (97%), Positives = 418/424 (98%) Query: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 Query: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM E+V V+F G D+IDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240 Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300 Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360 Query: 361 MDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPL 420 MDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPL Sbjct: 361 MDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPL 420 Query: 421 EGCR 424 EGCR Sbjct: 421 EGCR 424 >gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta1 [Homo sapiens] Length = 382 Score = 770 bits (1988), Expect = 0.0 Identities = 377/377 (100%), Positives = 377/377 (100%) Query: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 Query: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240 Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300 Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360 Query: 361 MDWEERSKNGVVKDQPS 377 MDWEERSKNGVVKDQPS Sbjct: 361 MDWEERSKNGVVKDQPS 377 >gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alpha1 [Homo sapiens] Length = 382 Score = 750 bits (1936), Expect = 0.0 Identities = 368/377 (97%), Positives = 371/377 (98%) Query: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 Query: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM E+V V+F G D+IDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240 Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300 Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360 Query: 361 MDWEERSKNGVVKDQPS 377 MDWEERSKNGVVKDQPS Sbjct: 361 MDWEERSKNGVVKDQPS 377 >gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo sapiens] Length = 464 Score = 733 bits (1893), Expect = 0.0 Identities = 364/426 (85%), Positives = 390/426 (91%), Gaps = 2/426 (0%) Query: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 MS SK D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL NVA+KKLSRP Sbjct: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98 Query: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 FQNQTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI Sbjct: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158 Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F Sbjct: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218 Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM EMV HK+LFPGRDYIDQWNKVIEQ Sbjct: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278 Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300 LGTP EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +K+K SQARDLLSK Sbjct: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338 Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360 MLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH IEEWKELIYKEV Sbjct: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398 Query: 361 MDWEERSKNGVVKDQ--PSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTG 418 M+ EE++KNGVVK Q PS AAV+S+ + SSS+NDISSMST+QTLASDTDSSL+AS G Sbjct: 399 MNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAG 458 Query: 419 PLEGCR 424 PL CR Sbjct: 459 PLGCCR 464 >gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo sapiens] Length = 426 Score = 733 bits (1893), Expect = 0.0 Identities = 364/426 (85%), Positives = 390/426 (91%), Gaps = 2/426 (0%) Query: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 MS SK D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL NVA+KKLSRP Sbjct: 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 60 Query: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 FQNQTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 120 Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM EMV HK+LFPGRDYIDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 240 Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300 LGTP EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +K+K SQARDLLSK Sbjct: 241 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 300 Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360 MLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH IEEWKELIYKEV Sbjct: 301 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 360 Query: 361 MDWEERSKNGVVKDQ--PSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTG 418 M+ EE++KNGVVK Q PS AAV+S+ + SSS+NDISSMST+QTLASDTDSSL+AS G Sbjct: 361 MNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAG 420 Query: 419 PLEGCR 424 PL CR Sbjct: 421 PLGCCR 426 >gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alpha2 [Homo sapiens] Length = 427 Score = 717 bits (1851), Expect = 0.0 Identities = 351/427 (82%), Positives = 384/427 (89%), Gaps = 3/427 (0%) Query: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L NVA+KKLSRP Sbjct: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60 Query: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120 Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240 MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIM EMV HK+LFPGRDYIDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240 Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300 LGTP EFMKKLQPTVR YVENRPKY G FE+LFPD +FP++SE +K+K SQARDLLSK Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300 Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360 MLVID KRISVDEAL+HPYI VWYDP+EAEAPPP+I D QL+EREH IEEWKELIYKEV Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360 Query: 361 MDWEERSKNGVVKDQPSD---AAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDAST 417 MD EER+KNGV++ QPS A ++ + PS SSS+ND+SSMST+ TLASDTDSSL+A+ Sbjct: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420 Query: 418 GPLEGCR 424 GPL CR Sbjct: 421 GPLGCCR 427 >gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta2 [Homo sapiens] Length = 427 Score = 707 bits (1824), Expect = 0.0 Identities = 348/427 (81%), Positives = 381/427 (89%), Gaps = 3/427 (0%) Query: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L NVA+KKLSRP Sbjct: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60 Query: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120 Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM EM+ VLFPG D+IDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240 Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300 LGTP EFMKKLQPTVR YVENRPKY G FE+LFPD +FP++SE +K+K SQARDLLSK Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300 Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360 MLVID KRISVDEAL+HPYI VWYDP+EAEAPPP+I D QL+EREH IEEWKELIYKEV Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360 Query: 361 MDWEERSKNGVVKDQPSD---AAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDAST 417 MD EER+KNGV++ QPS A ++ + PS SSS+ND+SSMST+ TLASDTDSSL+A+ Sbjct: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420 Query: 418 GPLEGCR 424 GPL CR Sbjct: 421 GPLGCCR 427 >gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo sapiens] Length = 422 Score = 681 bits (1756), Expect = 0.0 Identities = 332/380 (87%), Positives = 353/380 (92%) Query: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 MS SK D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL NVA+KKLSRP Sbjct: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98 Query: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 FQNQTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI Sbjct: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158 Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F Sbjct: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218 Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM EMV HK+LFPGRDYIDQWNKVIEQ Sbjct: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278 Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300 LGTP EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +K+K SQARDLLSK Sbjct: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338 Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360 MLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH IEEWKELIYKEV Sbjct: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398 Query: 361 MDWEERSKNGVVKDQPSDAA 380 M+ EE++KNGVVK QPS +A Sbjct: 399 MNSEEKTKNGVVKGQPSPSA 418 >gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha1 [Homo sapiens] Length = 384 Score = 666 bits (1719), Expect = 0.0 Identities = 323/380 (85%), Positives = 348/380 (91%) Query: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L NVA+KKLSRP Sbjct: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60 Query: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120 Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240 MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIM EMV HK+LFPGRDYIDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240 Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300 LGTP EFMKKLQPTVR YVENRPKY G FE+LFPD +FP++SE +K+K SQARDLLSK Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300 Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360 MLVID KRISVDEAL+HPYI VWYDP+EAEAPPP+I D QL+EREH IEEWKELIYKEV Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360 Query: 361 MDWEERSKNGVVKDQPSDAA 380 MD EER+KNGV++ QPS A Sbjct: 361 MDLEERTKNGVIRGQPSPLA 380 >gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta1 [Homo sapiens] Length = 384 Score = 656 bits (1692), Expect = 0.0 Identities = 320/380 (84%), Positives = 345/380 (90%) Query: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L NVA+KKLSRP Sbjct: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60 Query: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120 Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM EM+ VLFPG D+IDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240 Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300 LGTP EFMKKLQPTVR YVENRPKY G FE+LFPD +FP++SE +K+K SQARDLLSK Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300 Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360 MLVID KRISVDEAL+HPYI VWYDP+EAEAPPP+I D QL+EREH IEEWKELIYKEV Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360 Query: 361 MDWEERSKNGVVKDQPSDAA 380 MD EER+KNGV++ QPS A Sbjct: 361 MDLEERTKNGVIRGQPSPLA 380 >gi|20986508 mitogen-activated protein kinase 10 isoform 4 [Homo sapiens] Length = 277 Score = 493 bits (1269), Expect = e-139 Identities = 237/273 (86%), Positives = 253/273 (92%) Query: 108 MELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 167 MELMDANLCQVI MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI Sbjct: 1 MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60 Query: 168 LDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPG 227 LDFGLARTA T+FMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM EMV HK+LFPG Sbjct: 61 LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 120 Query: 228 RDYIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERD 287 RDYIDQWNKVIEQLGTP EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE + Sbjct: 121 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 180 Query: 288 KIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREH 347 K+K SQARDLLSKMLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH Sbjct: 181 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 240 Query: 348 AIEEWKELIYKEVMDWEERSKNGVVKDQPSDAA 380 IEEWKELIYKEVM+ EE++KNGVVK QPS +A Sbjct: 241 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSA 273 >gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gamma [Homo sapiens] Length = 242 Score = 447 bits (1150), Expect = e-126 Identities = 222/231 (96%), Positives = 224/231 (96%) Query: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 Query: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYI 231 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM E+V V+F G D I Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDRI 231 >gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo sapiens] Length = 360 Score = 333 bits (855), Expect = 1e-91 Identities = 178/357 (49%), Positives = 236/357 (66%), Gaps = 19/357 (5%) Query: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69 FY ++ + + V +RYQ L P+GSGA G VCAAFDT G+ VAVKKLSRPFQ+ HAKR Sbjct: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67 Query: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128 YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV LM A+L ++ +L + + Sbjct: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 Query: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188 +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T+ MT YV T Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185 Query: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAE 247 R+YRAPE++L M Y + VDIWSVGCIMAE++ + LFPG D+IDQ ++ +GTP AE Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 Query: 248 FMKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 306 +KK+ + RNY+++ + P + F +F A DLL KMLV+D Sbjct: 246 LLKKISSESARNYIQSLTQMPKMNFANVFIG------------ANPLAVDLLEKMLVLDS 293 Query: 307 DKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDW 363 DKRI+ +AL H Y ++DP + P YD E R+ I+EWK L Y EV+ + Sbjct: 294 DKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRDLLIDEWKSLTYDEVISF 348 >gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens] Length = 365 Score = 327 bits (839), Expect = 1e-89 Identities = 172/356 (48%), Positives = 234/356 (65%), Gaps = 17/356 (4%) Query: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69 FY V + + + K Y +GSGA G VC+A D G VA+KKLSRPFQ++ AKR Sbjct: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68 Query: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMS 129 AYREL+LLK + H+N+I LL+VFTP +L F D YLVM M +L +++ ME E++ Sbjct: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQ 128 Query: 130 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTR 189 YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A + MT YVVTR Sbjct: 129 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEMTGYVVTR 186 Query: 190 YYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEF 248 +YRAPEVIL M Y + VDIWSVGCIMAEM+ K LF G+DY+DQ ++++ G P EF Sbjct: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246 Query: 249 MKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307 ++KL ++Y+++ P+ P F +LFP + QA DLL KML +D D Sbjct: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPR------------ASPQAADLLEKMLELDVD 294 Query: 308 KRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDW 363 KR++ +AL HP+ + DP E E Q +D LE + ++EWK+ IYKE++++ Sbjct: 295 KRLTAAQALTHPFFEPFRDP-EEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNF 349 >gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens] Length = 364 Score = 326 bits (835), Expect = 3e-89 Identities = 175/359 (48%), Positives = 239/359 (66%), Gaps = 21/359 (5%) Query: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69 FY ++ + + V +R Q L+P+GSGA G VC+A+D L VAVKKLSRPFQ+ HA+R Sbjct: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67 Query: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERM 128 YREL LLK + H+N+I LL+VFTP ++E+F +VYLV LM A+L ++ + L E + Sbjct: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127 Query: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188 +L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A + MT YV T Sbjct: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA--DEEMTGYVAT 185 Query: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAE 247 R+YRAPE++L M Y + VDIWSVGCIMAE++ K LFPG DYIDQ +++E +GTPS E Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245 Query: 248 FMKKLQPT-VRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 306 + K+ R Y+++ P P +F + A DLL +MLV+D Sbjct: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIF------------RGANPLAIDLLGRMLVLDS 293 Query: 307 DKRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWE 364 D+R+S EAL H Y + ++DP E EA P YD +E +E +EEWKEL Y+EV+ ++ Sbjct: 294 DQRVSAAEALAHAYFSQYHDPEDEPEAEP---YDESVEAKERTLEEWKELTYQEVLSFK 349 >gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo sapiens] Length = 360 Score = 324 bits (830), Expect = 1e-88 Identities = 174/357 (48%), Positives = 233/357 (65%), Gaps = 19/357 (5%) Query: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69 FY ++ + + V +RYQ L P+GSGA G VCAAFDT G+ VAVKKLSRPFQ+ HAKR Sbjct: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67 Query: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128 YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV LM A+L ++ +L + + Sbjct: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 Query: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188 +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T+ MT YV T Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185 Query: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAE 247 R+YRAPE++L M Y + VDIWSVGCIMAE++ + LFPG D+I+Q +++ GTP A Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAY 245 Query: 248 FMKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 306 + ++ RNY+++ + P + F +F A DLL KMLV+D Sbjct: 246 LINRMPSHEARNYIQSLTQMPKMNFANVFIG------------ANPLAVDLLEKMLVLDS 293 Query: 307 DKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDW 363 DKRI+ +AL H Y ++DP + P YD E R+ I+EWK L Y EV+ + Sbjct: 294 DKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRDLLIDEWKSLTYDEVISF 348 >gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens] Length = 367 Score = 315 bits (808), Expect = 4e-86 Identities = 172/374 (45%), Positives = 243/374 (64%), Gaps = 21/374 (5%) Query: 8 SQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHA 67 S FY +V + + V Y+ L+P+GSGA G VC+A D G VA+KKL RPFQ++ A Sbjct: 9 SGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA 68 Query: 68 KRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI-HMELDHE 126 KRAYREL LLK + H+N+I LL+VFTP +TL++F D YLVM M +L +++ H +L + Sbjct: 69 KRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED 128 Query: 127 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYV 186 R+ +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT YV Sbjct: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYV 186 Query: 187 VTRYYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPS 245 VTR+YRAPEVIL M Y + VDIWSVGCIMAEM+ K LF G D++DQ ++++ GTP Sbjct: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246 Query: 246 AEFMKKLQ-PTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVI 304 AEF+++LQ +NY++ P+ F + + + A +LL KMLV+ Sbjct: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTN------------ASPLAVNLLEKMLVL 294 Query: 305 DPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWE 364 D ++R++ EAL HPY +D + P Q YD ++ + ++EWK + YKEV+ ++ Sbjct: 295 DAEQRVTAGEALAHPYFESLHD--TEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFK 352 Query: 365 ERSKNG--VVKDQP 376 + G V K+ P Sbjct: 353 PPRQLGARVSKETP 366 >gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo sapiens] Length = 297 Score = 286 bits (732), Expect = 2e-77 Identities = 146/269 (54%), Positives = 194/269 (72%), Gaps = 5/269 (1%) Query: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69 FY ++ + + V +RYQ L P+GSGA G VCAAFDT G+ VAVKKLSRPFQ+ HAKR Sbjct: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67 Query: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128 YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV LM A+L ++ +L + + Sbjct: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 Query: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188 +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T+ MT YV T Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185 Query: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAE 247 R+YRAPE++L M Y + VDIWSVGCIMAE++ + LFPG D+IDQ ++ +GTP AE Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 Query: 248 FMKKL-QPTVRNYVENRPKYPGIKFEELF 275 +KK+ + RNY+++ + P + F +F Sbjct: 246 LLKKISSESARNYIQSLTQMPKMNFANVF 274 >gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo sapiens] Length = 307 Score = 276 bits (705), Expect = 3e-74 Identities = 140/245 (57%), Positives = 181/245 (73%), Gaps = 4/245 (1%) Query: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69 FY ++ + + V +RYQ L P+GSGA G VCAAFDT G+ VAVKKLSRPFQ+ HAKR Sbjct: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67 Query: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128 YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV LM A+L ++ +L + + Sbjct: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 Query: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188 +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T+ MT YV T Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185 Query: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAE 247 R+YRAPE++L M Y + VDIWSVGCIMAE++ + LFPG D+IDQ ++ +GTP AE Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 Query: 248 FMKKL 252 +KK+ Sbjct: 246 LLKKI 250 >gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens] Length = 360 Score = 266 bits (679), Expect = 3e-71 Identities = 147/353 (41%), Positives = 226/353 (64%), Gaps = 24/353 (6%) Query: 15 VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYREL 74 V F V RY L IG GA G+VC+A+D V + VA+KK+S PF++QT+ +R RE+ Sbjct: 14 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREI 72 Query: 75 VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERMSYLLY 133 +L H+NII + ++ T+E+ +DVY+V +LM+ +L +++ + L ++ + Y LY Sbjct: 73 KILLRFRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 131 Query: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF----MMTPYVVTR 189 Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A + +T YV TR Sbjct: 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 191 Query: 190 YYRAPEVIL-GMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEF 248 +YRAPE++L GY +++DIWSVGCI+AEM+ ++ +FPG+ Y+DQ N ++ LG+PS E Sbjct: 192 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251 Query: 249 MK-KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307 + + RNY+ + P + + LFP+ S+A DLL KML +P Sbjct: 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPN------------ADSKALDLLDKMLTFNPH 299 Query: 308 KRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKE 359 KRI V++AL HPY+ +YDP+ E A P +D +L++ E+ KELI++E Sbjct: 300 KRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350 >gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens] Length = 360 Score = 266 bits (679), Expect = 3e-71 Identities = 147/353 (41%), Positives = 226/353 (64%), Gaps = 24/353 (6%) Query: 15 VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYREL 74 V F V RY L IG GA G+VC+A+D V + VA+KK+S PF++QT+ +R RE+ Sbjct: 14 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREI 72 Query: 75 VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERMSYLLY 133 +L H+NII + ++ T+E+ +DVY+V +LM+ +L +++ + L ++ + Y LY Sbjct: 73 KILLRFRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 131 Query: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF----MMTPYVVTR 189 Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A + +T YV TR Sbjct: 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 191 Query: 190 YYRAPEVIL-GMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEF 248 +YRAPE++L GY +++DIWSVGCI+AEM+ ++ +FPG+ Y+DQ N ++ LG+PS E Sbjct: 192 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251 Query: 249 MK-KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307 + + RNY+ + P + + LFP+ S+A DLL KML +P Sbjct: 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPN------------ADSKALDLLDKMLTFNPH 299 Query: 308 KRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKE 359 KRI V++AL HPY+ +YDP+ E A P +D +L++ E+ KELI++E Sbjct: 300 KRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350 >gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo sapiens] Length = 379 Score = 263 bits (673), Expect = 2e-70 Identities = 146/353 (41%), Positives = 224/353 (63%), Gaps = 24/353 (6%) Query: 15 VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYREL 74 V F V RY QL+ IG GA G+V +A+D V VA+KK+S PF++QT+ +R RE+ Sbjct: 31 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 89 Query: 75 VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERMSYLLY 133 +L H+N+I + ++ TLE +DVY+V +LM+ +L +++ +L ++ + Y LY Sbjct: 90 QILLRFRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 148 Query: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF----MMTPYVVTR 189 Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR Sbjct: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208 Query: 190 YYRAPEVIL-GMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEF 248 +YRAPE++L GY +++DIWSVGCI+AEM+ ++ +FPG+ Y+DQ N ++ LG+PS E Sbjct: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268 Query: 249 MK-KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307 + + RNY+++ P + + +LFP S+A DLL +ML +P+ Sbjct: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPK------------SDSKALDLLDRMLTFNPN 316 Query: 308 KRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKE 359 KRI+V+EAL HPY+ +YDP E A P + +L++ E KELI++E Sbjct: 317 KRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 367 >gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo sapiens] Length = 357 Score = 258 bits (659), Expect = 7e-69 Identities = 137/328 (41%), Positives = 210/328 (64%), Gaps = 21/328 (6%) Query: 15 VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYREL 74 V F V RY QL+ IG GA G+V +A+D V VA+KK+S PF++QT+ +R RE+ Sbjct: 31 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 89 Query: 75 VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERMSYLLY 133 +L H+N+I + ++ TLE +DVY+V +LM+ +L +++ +L ++ + Y LY Sbjct: 90 QILLRFRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 148 Query: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF----MMTPYVVTR 189 Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR Sbjct: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208 Query: 190 YYRAPEVIL-GMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEF 248 +YRAPE++L GY +++DIWSVGCI+AEM+ ++ +FPG+ Y+DQ N ++ LG+PS E Sbjct: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268 Query: 249 MK-KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307 + + RNY+++ P + + +LFP S+A DLL +ML +P+ Sbjct: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPK------------SDSKALDLLDRMLTFNPN 316 Query: 308 KRISVDEALRHPYITVWYDPAEAEAPPP 335 KRI+V+EAL HPY+ +YDP + P Sbjct: 317 KRITVEEALAHPYLEQYYDPTDEVGQSP 344 >gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo sapiens] Length = 816 Score = 255 bits (652), Expect = 5e-68 Identities = 149/380 (39%), Positives = 224/380 (58%), Gaps = 28/380 (7%) Query: 17 DSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVL 76 D TF V Y+ ++ IG+GA G+V +A + G VA+KK+ F T+AKR REL + Sbjct: 46 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105 Query: 77 LKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH--MELDHERMSYLLYQ 134 LK H NII++ ++ P EF+ VY+V++LM+++L Q+IH L E + Y LYQ Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165 Query: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTN-----FMMTPYVVTR 189 +L G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR CT+ + MT YV TR Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225 Query: 190 YYRAPEVILGM-GYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEF 248 +YRAPE++L + Y + +D+WSVGCI EM+ + LFPG++Y+ Q ++ LGTPS Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285 Query: 249 MKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307 ++ + VR Y+++ P + +E ++P QA LL +ML +P Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPG------------ADRQALSLLGRMLRFEPS 333 Query: 308 KRISVDEALRHPYITVWYDP-AEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEER 366 RIS ALRHP++ ++DP E + PP +D + E KE I E+ D+ R Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPP--FDFAFDREALTRERIKEAIVAEIEDFHAR 391 Query: 367 SKNGV---VKDQPSDAAVSS 383 + G+ ++ QPS V+S Sbjct: 392 -REGIRQQIRFQPSLQPVAS 410 >gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo sapiens] Length = 816 Score = 255 bits (652), Expect = 5e-68 Identities = 149/380 (39%), Positives = 224/380 (58%), Gaps = 28/380 (7%) Query: 17 DSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVL 76 D TF V Y+ ++ IG+GA G+V +A + G VA+KK+ F T+AKR REL + Sbjct: 46 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105 Query: 77 LKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH--MELDHERMSYLLYQ 134 LK H NII++ ++ P EF+ VY+V++LM+++L Q+IH L E + Y LYQ Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165 Query: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTN-----FMMTPYVVTR 189 +L G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR CT+ + MT YV TR Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225 Query: 190 YYRAPEVILGM-GYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEF 248 +YRAPE++L + Y + +D+WSVGCI EM+ + LFPG++Y+ Q ++ LGTPS Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285 Query: 249 MKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307 ++ + VR Y+++ P + +E ++P QA LL +ML +P Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPG------------ADRQALSLLGRMLRFEPS 333 Query: 308 KRISVDEALRHPYITVWYDP-AEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEER 366 RIS ALRHP++ ++DP E + PP +D + E KE I E+ D+ R Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPP--FDFAFDREALTRERIKEAIVAEIEDFHAR 391 Query: 367 SKNGV---VKDQPSDAAVSS 383 + G+ ++ QPS V+S Sbjct: 392 -REGIRQQIRFQPSLQPVAS 410 >gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo sapiens] Length = 816 Score = 255 bits (652), Expect = 5e-68 Identities = 149/380 (39%), Positives = 224/380 (58%), Gaps = 28/380 (7%) Query: 17 DSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVL 76 D TF V Y+ ++ IG+GA G+V +A + G VA+KK+ F T+AKR REL + Sbjct: 46 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105 Query: 77 LKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH--MELDHERMSYLLYQ 134 LK H NII++ ++ P EF+ VY+V++LM+++L Q+IH L E + Y LYQ Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165 Query: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTN-----FMMTPYVVTR 189 +L G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR CT+ + MT YV TR Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225 Query: 190 YYRAPEVILGM-GYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEF 248 +YRAPE++L + Y + +D+WSVGCI EM+ + LFPG++Y+ Q ++ LGTPS Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285 Query: 249 MKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307 ++ + VR Y+++ P + +E ++P QA LL +ML +P Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPG------------ADRQALSLLGRMLRFEPS 333 Query: 308 KRISVDEALRHPYITVWYDP-AEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEER 366 RIS ALRHP++ ++DP E + PP +D + E KE I E+ D+ R Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPP--FDFAFDREALTRERIKEAIVAEIEDFHAR 391 Query: 367 SKNGV---VKDQPSDAAVSS 383 + G+ ++ QPS V+S Sbjct: 392 -REGIRQQIRFQPSLQPVAS 410 >gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo sapiens] Length = 335 Score = 218 bits (555), Expect = 8e-57 Identities = 133/352 (37%), Positives = 197/352 (55%), Gaps = 66/352 (18%) Query: 15 VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYREL 74 V F V RY QL+ IG GA G+V +A+D V VA+KK+S PF++QT+ +R RE+ Sbjct: 31 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 89 Query: 75 VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERMSYLLY 133 +L H+N+I + ++ TLE +DVY+V +LM+ +L +++ +L ++ + Y LY Sbjct: 90 QILLRFRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 148 Query: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF----MMTPYVVTR 189 Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR Sbjct: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208 Query: 190 YYRAPEVILGM-GYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEF 248 +YRAPE++L GY +++DIWSVGCI+AEM+ Sbjct: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEML----------------------------- 239 Query: 249 MKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDK 308 NRP IFP + D++ A DLL +ML +P+K Sbjct: 240 ------------SNRP--------------IFPGKHYLDQLNHILALDLLDRMLTFNPNK 273 Query: 309 RISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKE 359 RI+V+EAL HPY+ +YDP E A P + +L++ E KELI++E Sbjct: 274 RITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 323 >gi|149408126 nemo like kinase [Homo sapiens] Length = 527 Score = 211 bits (536), Expect = 1e-54 Identities = 122/298 (40%), Positives = 180/298 (60%), Gaps = 18/298 (6%) Query: 30 KPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLL 89 +PIG GA G+V + D G VA+KK+ FQN KR +REL +L H N++S L Sbjct: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201 Query: 90 NVFTPQKTLEEFQDVYLVMELMDANLCQVI--HMELDHERMSYLLYQMLCGIKHLHSAGI 147 ++ P ++ F+++Y+V ELM ++L ++I L + + LYQ+L G+K+LHSAGI Sbjct: 202 DILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260 Query: 148 IHRDLKPSNIVVKSDCTLKILDFGLART--ACTNFMMTPYVVTRYYRAPEVILGMGYKEN 205 +HRD+KP N++V S+C LKI DFGLAR + MT VVT+YYRAPE+++G + N Sbjct: 261 LHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSN 320 Query: 206 -VDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRP 264 +DIWSVGCI AE++ ++LF + I Q + + + LGTPS E M+ + ++ P Sbjct: 321 AIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGP 380 Query: 265 -KYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI 321 K P + ++ S+ T +A LL +MLV DP KRIS +AL HPY+ Sbjct: 381 HKQPSLPV-------LYTLSSQ----ATHEAVHLLCRMLVFDPSKRISAKDALAHPYL 427 >gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens] Length = 544 Score = 198 bits (503), Expect = 9e-51 Identities = 123/355 (34%), Positives = 202/355 (56%), Gaps = 32/355 (9%) Query: 22 VLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCV- 80 +++RY + +G GA GIV A D G VA+KK+ F+++T A+R +RE+ LL+ Sbjct: 9 IVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG 68 Query: 81 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME--LDHERMSYLLYQMLCG 138 +H NIISLL+V E +D+YLV E MD +L VI L + + YQ+L Sbjct: 69 DHPNIISLLDVIRA----ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRA 124 Query: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART------ACTNFMMTPYVVTRYYR 192 + LHS ++HRD KPSN+++ ++CT+K+ DFGLAR+ + +T YV TR+YR Sbjct: 125 TRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYR 184 Query: 193 APEVILGM-GYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFMKK 251 APEV+L Y VD+WS+GCI+ EM+ + LFPG + Q ++E + PS E + Sbjct: 185 APEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLA 244 Query: 252 L----QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307 L + +V + + +RP+ D + P ++ + +A DLL ++LV PD Sbjct: 245 LGSGCRASVLHQLGSRPRQT--------LDALLPPDT------SPEALDLLRRLLVFAPD 290 Query: 308 KRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMD 362 KR+S +AL+HPY+ ++ P++ A + E + ++ E++ +Y+ +++ Sbjct: 291 KRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILE 345 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.318 0.133 0.396 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,195,542 Number of Sequences: 37866 Number of extensions: 710242 Number of successful extensions: 4690 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 761 Number of HSP's successfully gapped in prelim test: 68 Number of HSP's that attempted gapping in prelim test: 2297 Number of HSP's gapped (non-prelim): 1337 length of query: 424 length of database: 18,247,518 effective HSP length: 105 effective length of query: 319 effective length of database: 14,271,588 effective search space: 4552636572 effective search space used: 4552636572 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.