Guide to the Human Genome
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Search of human proteins with 21237745

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21237745 mitogen-activated protein kinase 9 isoform JNK2
beta2 [Homo sapiens]
         (424 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta...   858   0.0  
gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alph...   838   0.0  
gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta...   770   0.0  
gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alph...   750   0.0  
gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo ...   733   0.0  
gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo ...   733   0.0  
gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alph...   717   0.0  
gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta...   707   0.0  
gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo s...   681   0.0  
gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha...   666   0.0  
gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta...   656   0.0  
gi|20986508 mitogen-activated protein kinase 10 isoform 4 [Homo ...   493   e-139
gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gam...   447   e-126
gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ...   333   1e-91
gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]         327   1e-89
gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]        326   3e-89
gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo s...   324   1e-88
gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]        315   4e-86
gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo ...   286   2e-77
gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo ...   276   3e-74
gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]         266   3e-71
gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]         266   3e-71
gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s...   263   2e-70
gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s...   258   7e-69
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s...   255   5e-68
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ...   255   5e-68
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ...   255   5e-68
gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo ...   218   8e-57
gi|149408126 nemo like kinase [Homo sapiens]                          211   1e-54
gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]        198   9e-51

>gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta2
           [Homo sapiens]
          Length = 424

 Score =  858 bits (2216), Expect = 0.0
 Identities = 424/424 (100%), Positives = 424/424 (100%)

Query: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
           MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP
Sbjct: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60

Query: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
           FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH
Sbjct: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120

Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180

Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240

Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
           LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK
Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300

Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
           MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV
Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360

Query: 361 MDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPL 420
           MDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPL
Sbjct: 361 MDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPL 420

Query: 421 EGCR 424
           EGCR
Sbjct: 421 EGCR 424


>gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alpha2
           [Homo sapiens]
          Length = 424

 Score =  838 bits (2164), Expect = 0.0
 Identities = 415/424 (97%), Positives = 418/424 (98%)

Query: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
           MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP
Sbjct: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60

Query: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
           FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH
Sbjct: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120

Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180

Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM E+V   V+F G D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240

Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
           LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK
Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300

Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
           MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV
Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360

Query: 361 MDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPL 420
           MDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPL
Sbjct: 361 MDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPL 420

Query: 421 EGCR 424
           EGCR
Sbjct: 421 EGCR 424


>gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta1
           [Homo sapiens]
          Length = 382

 Score =  770 bits (1988), Expect = 0.0
 Identities = 377/377 (100%), Positives = 377/377 (100%)

Query: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
           MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP
Sbjct: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60

Query: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
           FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH
Sbjct: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120

Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180

Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240

Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
           LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK
Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300

Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
           MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV
Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360

Query: 361 MDWEERSKNGVVKDQPS 377
           MDWEERSKNGVVKDQPS
Sbjct: 361 MDWEERSKNGVVKDQPS 377


>gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alpha1
           [Homo sapiens]
          Length = 382

 Score =  750 bits (1936), Expect = 0.0
 Identities = 368/377 (97%), Positives = 371/377 (98%)

Query: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
           MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP
Sbjct: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60

Query: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
           FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH
Sbjct: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120

Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180

Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM E+V   V+F G D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240

Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
           LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK
Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300

Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
           MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV
Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360

Query: 361 MDWEERSKNGVVKDQPS 377
           MDWEERSKNGVVKDQPS
Sbjct: 361 MDWEERSKNGVVKDQPS 377


>gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo
           sapiens]
          Length = 464

 Score =  733 bits (1893), Expect = 0.0
 Identities = 364/426 (85%), Positives = 390/426 (91%), Gaps = 2/426 (0%)

Query: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
           MS SK D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL  NVA+KKLSRP
Sbjct: 39  MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98

Query: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
           FQNQTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI 
Sbjct: 99  FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158

Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218

Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM EMV HK+LFPGRDYIDQWNKVIEQ
Sbjct: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278

Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
           LGTP  EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338

Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
           MLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH IEEWKELIYKEV
Sbjct: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398

Query: 361 MDWEERSKNGVVKDQ--PSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTG 418
           M+ EE++KNGVVK Q  PS AAV+S+ +   SSS+NDISSMST+QTLASDTDSSL+AS G
Sbjct: 399 MNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAG 458

Query: 419 PLEGCR 424
           PL  CR
Sbjct: 459 PLGCCR 464


>gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo
           sapiens]
          Length = 426

 Score =  733 bits (1893), Expect = 0.0
 Identities = 364/426 (85%), Positives = 390/426 (91%), Gaps = 2/426 (0%)

Query: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
           MS SK D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL  NVA+KKLSRP
Sbjct: 1   MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 60

Query: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
           FQNQTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI 
Sbjct: 61  FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 120

Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180

Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM EMV HK+LFPGRDYIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 240

Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
           LGTP  EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 300

Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
           MLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 360

Query: 361 MDWEERSKNGVVKDQ--PSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTG 418
           M+ EE++KNGVVK Q  PS AAV+S+ +   SSS+NDISSMST+QTLASDTDSSL+AS G
Sbjct: 361 MNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAG 420

Query: 419 PLEGCR 424
           PL  CR
Sbjct: 421 PLGCCR 426


>gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alpha2
           [Homo sapiens]
          Length = 427

 Score =  717 bits (1851), Expect = 0.0
 Identities = 351/427 (82%), Positives = 384/427 (89%), Gaps = 3/427 (0%)

Query: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
           MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L  NVA+KKLSRP
Sbjct: 1   MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60

Query: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
           FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI 
Sbjct: 61  FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120

Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180

Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240
           MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIM EMV HK+LFPGRDYIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240

Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
           LGTP  EFMKKLQPTVR YVENRPKY G  FE+LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300

Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
           MLVID  KRISVDEAL+HPYI VWYDP+EAEAPPP+I D QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360

Query: 361 MDWEERSKNGVVKDQPSD---AAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDAST 417
           MD EER+KNGV++ QPS    A ++ +  PS SSS+ND+SSMST+ TLASDTDSSL+A+ 
Sbjct: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420

Query: 418 GPLEGCR 424
           GPL  CR
Sbjct: 421 GPLGCCR 427


>gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta2
           [Homo sapiens]
          Length = 427

 Score =  707 bits (1824), Expect = 0.0
 Identities = 348/427 (81%), Positives = 381/427 (89%), Gaps = 3/427 (0%)

Query: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
           MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L  NVA+KKLSRP
Sbjct: 1   MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60

Query: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
           FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI 
Sbjct: 61  FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120

Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180

Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM EM+   VLFPG D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240

Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
           LGTP  EFMKKLQPTVR YVENRPKY G  FE+LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300

Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
           MLVID  KRISVDEAL+HPYI VWYDP+EAEAPPP+I D QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360

Query: 361 MDWEERSKNGVVKDQPSD---AAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDAST 417
           MD EER+KNGV++ QPS    A ++ +  PS SSS+ND+SSMST+ TLASDTDSSL+A+ 
Sbjct: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420

Query: 418 GPLEGCR 424
           GPL  CR
Sbjct: 421 GPLGCCR 427


>gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo
           sapiens]
          Length = 422

 Score =  681 bits (1756), Expect = 0.0
 Identities = 332/380 (87%), Positives = 353/380 (92%)

Query: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
           MS SK D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL  NVA+KKLSRP
Sbjct: 39  MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98

Query: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
           FQNQTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI 
Sbjct: 99  FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158

Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218

Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM EMV HK+LFPGRDYIDQWNKVIEQ
Sbjct: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278

Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
           LGTP  EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338

Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
           MLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH IEEWKELIYKEV
Sbjct: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398

Query: 361 MDWEERSKNGVVKDQPSDAA 380
           M+ EE++KNGVVK QPS +A
Sbjct: 399 MNSEEKTKNGVVKGQPSPSA 418


>gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha1
           [Homo sapiens]
          Length = 384

 Score =  666 bits (1719), Expect = 0.0
 Identities = 323/380 (85%), Positives = 348/380 (91%)

Query: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
           MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L  NVA+KKLSRP
Sbjct: 1   MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60

Query: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
           FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI 
Sbjct: 61  FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120

Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180

Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240
           MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIM EMV HK+LFPGRDYIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240

Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
           LGTP  EFMKKLQPTVR YVENRPKY G  FE+LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300

Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
           MLVID  KRISVDEAL+HPYI VWYDP+EAEAPPP+I D QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360

Query: 361 MDWEERSKNGVVKDQPSDAA 380
           MD EER+KNGV++ QPS  A
Sbjct: 361 MDLEERTKNGVIRGQPSPLA 380


>gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta1
           [Homo sapiens]
          Length = 384

 Score =  656 bits (1692), Expect = 0.0
 Identities = 320/380 (84%), Positives = 345/380 (90%)

Query: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
           MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L  NVA+KKLSRP
Sbjct: 1   MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60

Query: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
           FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI 
Sbjct: 61  FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120

Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180

Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM EM+   VLFPG D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240

Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
           LGTP  EFMKKLQPTVR YVENRPKY G  FE+LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300

Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
           MLVID  KRISVDEAL+HPYI VWYDP+EAEAPPP+I D QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360

Query: 361 MDWEERSKNGVVKDQPSDAA 380
           MD EER+KNGV++ QPS  A
Sbjct: 361 MDLEERTKNGVIRGQPSPLA 380


>gi|20986508 mitogen-activated protein kinase 10 isoform 4 [Homo
           sapiens]
          Length = 277

 Score =  493 bits (1269), Expect = e-139
 Identities = 237/273 (86%), Positives = 253/273 (92%)

Query: 108 MELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 167
           MELMDANLCQVI MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI
Sbjct: 1   MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60

Query: 168 LDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPG 227
           LDFGLARTA T+FMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM EMV HK+LFPG
Sbjct: 61  LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 120

Query: 228 RDYIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERD 287
           RDYIDQWNKVIEQLGTP  EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +
Sbjct: 121 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 180

Query: 288 KIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREH 347
           K+K SQARDLLSKMLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH
Sbjct: 181 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 240

Query: 348 AIEEWKELIYKEVMDWEERSKNGVVKDQPSDAA 380
            IEEWKELIYKEVM+ EE++KNGVVK QPS +A
Sbjct: 241 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSA 273


>gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gamma
           [Homo sapiens]
          Length = 242

 Score =  447 bits (1150), Expect = e-126
 Identities = 222/231 (96%), Positives = 224/231 (96%)

Query: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
           MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP
Sbjct: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60

Query: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
           FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH
Sbjct: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120

Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180

Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYI 231
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM E+V   V+F G D I
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDRI 231


>gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo
           sapiens]
          Length = 360

 Score =  333 bits (855), Expect = 1e-91
 Identities = 178/357 (49%), Positives = 236/357 (66%), Gaps = 19/357 (5%)

Query: 10  FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
           FY  ++  + + V +RYQ L P+GSGA G VCAAFDT  G+ VAVKKLSRPFQ+  HAKR
Sbjct: 8   FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67

Query: 70  AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128
            YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV  LM A+L  ++   +L  + +
Sbjct: 68  TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127

Query: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188
            +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKILDFGLAR   T+  MT YV T
Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185

Query: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAE 247
           R+YRAPE++L  M Y + VDIWSVGCIMAE++  + LFPG D+IDQ   ++  +GTP AE
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245

Query: 248 FMKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 306
            +KK+   + RNY+++  + P + F  +F                  A DLL KMLV+D 
Sbjct: 246 LLKKISSESARNYIQSLTQMPKMNFANVFIG------------ANPLAVDLLEKMLVLDS 293

Query: 307 DKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDW 363
           DKRI+  +AL H Y   ++DP +     P  YD   E R+  I+EWK L Y EV+ +
Sbjct: 294 DKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRDLLIDEWKSLTYDEVISF 348


>gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]
          Length = 365

 Score =  327 bits (839), Expect = 1e-89
 Identities = 172/356 (48%), Positives = 234/356 (65%), Gaps = 17/356 (4%)

Query: 10  FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
           FY   V  + + + K Y     +GSGA G VC+A D   G  VA+KKLSRPFQ++  AKR
Sbjct: 9   FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68

Query: 70  AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMS 129
           AYREL+LLK + H+N+I LL+VFTP  +L  F D YLVM  M  +L +++ ME   E++ 
Sbjct: 69  AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQ 128

Query: 130 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTR 189
           YL+YQML G+K++HSAG++HRDLKP N+ V  DC LKILDFGLAR A  +  MT YVVTR
Sbjct: 129 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEMTGYVVTR 186

Query: 190 YYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEF 248
           +YRAPEVIL  M Y + VDIWSVGCIMAEM+  K LF G+DY+DQ  ++++  G P  EF
Sbjct: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246

Query: 249 MKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
           ++KL     ++Y+++ P+ P   F +LFP              + QA DLL KML +D D
Sbjct: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPR------------ASPQAADLLEKMLELDVD 294

Query: 308 KRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDW 363
           KR++  +AL HP+   + DP E E    Q +D  LE  +  ++EWK+ IYKE++++
Sbjct: 295 KRLTAAQALTHPFFEPFRDP-EEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNF 349


>gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
          Length = 364

 Score =  326 bits (835), Expect = 3e-89
 Identities = 175/359 (48%), Positives = 239/359 (66%), Gaps = 21/359 (5%)

Query: 10  FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
           FY  ++  + + V +R Q L+P+GSGA G VC+A+D  L   VAVKKLSRPFQ+  HA+R
Sbjct: 8   FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67

Query: 70  AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERM 128
            YREL LLK + H+N+I LL+VFTP  ++E+F +VYLV  LM A+L  ++  + L  E +
Sbjct: 68  TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127

Query: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188
            +L+YQ+L G+K++HSAGIIHRDLKPSN+ V  DC L+ILDFGLAR A  +  MT YV T
Sbjct: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA--DEEMTGYVAT 185

Query: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAE 247
           R+YRAPE++L  M Y + VDIWSVGCIMAE++  K LFPG DYIDQ  +++E +GTPS E
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245

Query: 248 FMKKLQPT-VRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 306
            + K+     R Y+++ P  P      +F            +     A DLL +MLV+D 
Sbjct: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIF------------RGANPLAIDLLGRMLVLDS 293

Query: 307 DKRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWE 364
           D+R+S  EAL H Y + ++DP  E EA P   YD  +E +E  +EEWKEL Y+EV+ ++
Sbjct: 294 DQRVSAAEALAHAYFSQYHDPEDEPEAEP---YDESVEAKERTLEEWKELTYQEVLSFK 349


>gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo
           sapiens]
          Length = 360

 Score =  324 bits (830), Expect = 1e-88
 Identities = 174/357 (48%), Positives = 233/357 (65%), Gaps = 19/357 (5%)

Query: 10  FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
           FY  ++  + + V +RYQ L P+GSGA G VCAAFDT  G+ VAVKKLSRPFQ+  HAKR
Sbjct: 8   FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67

Query: 70  AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128
            YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV  LM A+L  ++   +L  + +
Sbjct: 68  TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127

Query: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188
            +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKILDFGLAR   T+  MT YV T
Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185

Query: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAE 247
           R+YRAPE++L  M Y + VDIWSVGCIMAE++  + LFPG D+I+Q  +++   GTP A 
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAY 245

Query: 248 FMKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 306
            + ++     RNY+++  + P + F  +F                  A DLL KMLV+D 
Sbjct: 246 LINRMPSHEARNYIQSLTQMPKMNFANVFIG------------ANPLAVDLLEKMLVLDS 293

Query: 307 DKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDW 363
           DKRI+  +AL H Y   ++DP +     P  YD   E R+  I+EWK L Y EV+ +
Sbjct: 294 DKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRDLLIDEWKSLTYDEVISF 348


>gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]
          Length = 367

 Score =  315 bits (808), Expect = 4e-86
 Identities = 172/374 (45%), Positives = 243/374 (64%), Gaps = 21/374 (5%)

Query: 8   SQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHA 67
           S FY  +V  + + V   Y+ L+P+GSGA G VC+A D   G  VA+KKL RPFQ++  A
Sbjct: 9   SGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA 68

Query: 68  KRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI-HMELDHE 126
           KRAYREL LLK + H+N+I LL+VFTP +TL++F D YLVM  M  +L +++ H +L  +
Sbjct: 69  KRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED 128

Query: 127 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYV 186
           R+ +L+YQML G++++H+AGIIHRDLKP N+ V  DC LKILDFGLAR A +   MT YV
Sbjct: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYV 186

Query: 187 VTRYYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPS 245
           VTR+YRAPEVIL  M Y + VDIWSVGCIMAEM+  K LF G D++DQ  ++++  GTP 
Sbjct: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246

Query: 246 AEFMKKLQ-PTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVI 304
           AEF+++LQ    +NY++  P+     F  +  +             +  A +LL KMLV+
Sbjct: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTN------------ASPLAVNLLEKMLVL 294

Query: 305 DPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWE 364
           D ++R++  EAL HPY    +D    + P  Q YD   ++ +  ++EWK + YKEV+ ++
Sbjct: 295 DAEQRVTAGEALAHPYFESLHD--TEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFK 352

Query: 365 ERSKNG--VVKDQP 376
              + G  V K+ P
Sbjct: 353 PPRQLGARVSKETP 366


>gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo
           sapiens]
          Length = 297

 Score =  286 bits (732), Expect = 2e-77
 Identities = 146/269 (54%), Positives = 194/269 (72%), Gaps = 5/269 (1%)

Query: 10  FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
           FY  ++  + + V +RYQ L P+GSGA G VCAAFDT  G+ VAVKKLSRPFQ+  HAKR
Sbjct: 8   FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67

Query: 70  AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128
            YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV  LM A+L  ++   +L  + +
Sbjct: 68  TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127

Query: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188
            +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKILDFGLAR   T+  MT YV T
Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185

Query: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAE 247
           R+YRAPE++L  M Y + VDIWSVGCIMAE++  + LFPG D+IDQ   ++  +GTP AE
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245

Query: 248 FMKKL-QPTVRNYVENRPKYPGIKFEELF 275
            +KK+   + RNY+++  + P + F  +F
Sbjct: 246 LLKKISSESARNYIQSLTQMPKMNFANVF 274


>gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo
           sapiens]
          Length = 307

 Score =  276 bits (705), Expect = 3e-74
 Identities = 140/245 (57%), Positives = 181/245 (73%), Gaps = 4/245 (1%)

Query: 10  FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
           FY  ++  + + V +RYQ L P+GSGA G VCAAFDT  G+ VAVKKLSRPFQ+  HAKR
Sbjct: 8   FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67

Query: 70  AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128
            YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV  LM A+L  ++   +L  + +
Sbjct: 68  TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127

Query: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188
            +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKILDFGLAR   T+  MT YV T
Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185

Query: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAE 247
           R+YRAPE++L  M Y + VDIWSVGCIMAE++  + LFPG D+IDQ   ++  +GTP AE
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245

Query: 248 FMKKL 252
            +KK+
Sbjct: 246 LLKKI 250


>gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]
          Length = 360

 Score =  266 bits (679), Expect = 3e-71
 Identities = 147/353 (41%), Positives = 226/353 (64%), Gaps = 24/353 (6%)

Query: 15  VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYREL 74
           V    F V  RY  L  IG GA G+VC+A+D V  + VA+KK+S PF++QT+ +R  RE+
Sbjct: 14  VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREI 72

Query: 75  VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERMSYLLY 133
            +L    H+NII + ++     T+E+ +DVY+V +LM+ +L +++  + L ++ + Y LY
Sbjct: 73  KILLRFRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 131

Query: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF----MMTPYVVTR 189
           Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A  +      +T YV TR
Sbjct: 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 191

Query: 190 YYRAPEVIL-GMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEF 248
           +YRAPE++L   GY +++DIWSVGCI+AEM+ ++ +FPG+ Y+DQ N ++  LG+PS E 
Sbjct: 192 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251

Query: 249 MK-KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
           +   +    RNY+ + P    + +  LFP+              S+A DLL KML  +P 
Sbjct: 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPN------------ADSKALDLLDKMLTFNPH 299

Query: 308 KRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKE 359
           KRI V++AL HPY+  +YDP+ E  A  P  +D +L++     E+ KELI++E
Sbjct: 300 KRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350


>gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]
          Length = 360

 Score =  266 bits (679), Expect = 3e-71
 Identities = 147/353 (41%), Positives = 226/353 (64%), Gaps = 24/353 (6%)

Query: 15  VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYREL 74
           V    F V  RY  L  IG GA G+VC+A+D V  + VA+KK+S PF++QT+ +R  RE+
Sbjct: 14  VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREI 72

Query: 75  VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERMSYLLY 133
            +L    H+NII + ++     T+E+ +DVY+V +LM+ +L +++  + L ++ + Y LY
Sbjct: 73  KILLRFRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 131

Query: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF----MMTPYVVTR 189
           Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A  +      +T YV TR
Sbjct: 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 191

Query: 190 YYRAPEVIL-GMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEF 248
           +YRAPE++L   GY +++DIWSVGCI+AEM+ ++ +FPG+ Y+DQ N ++  LG+PS E 
Sbjct: 192 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251

Query: 249 MK-KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
           +   +    RNY+ + P    + +  LFP+              S+A DLL KML  +P 
Sbjct: 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPN------------ADSKALDLLDKMLTFNPH 299

Query: 308 KRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKE 359
           KRI V++AL HPY+  +YDP+ E  A  P  +D +L++     E+ KELI++E
Sbjct: 300 KRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350


>gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo
           sapiens]
          Length = 379

 Score =  263 bits (673), Expect = 2e-70
 Identities = 146/353 (41%), Positives = 224/353 (63%), Gaps = 24/353 (6%)

Query: 15  VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYREL 74
           V    F V  RY QL+ IG GA G+V +A+D V    VA+KK+S PF++QT+ +R  RE+
Sbjct: 31  VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 89

Query: 75  VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERMSYLLY 133
            +L    H+N+I + ++     TLE  +DVY+V +LM+ +L +++   +L ++ + Y LY
Sbjct: 90  QILLRFRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 148

Query: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF----MMTPYVVTR 189
           Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A         +T YV TR
Sbjct: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208

Query: 190 YYRAPEVIL-GMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEF 248
           +YRAPE++L   GY +++DIWSVGCI+AEM+ ++ +FPG+ Y+DQ N ++  LG+PS E 
Sbjct: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268

Query: 249 MK-KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
           +   +    RNY+++ P    + + +LFP               S+A DLL +ML  +P+
Sbjct: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPK------------SDSKALDLLDRMLTFNPN 316

Query: 308 KRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKE 359
           KRI+V+EAL HPY+  +YDP  E  A  P  +  +L++     E  KELI++E
Sbjct: 317 KRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 367


>gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo
           sapiens]
          Length = 357

 Score =  258 bits (659), Expect = 7e-69
 Identities = 137/328 (41%), Positives = 210/328 (64%), Gaps = 21/328 (6%)

Query: 15  VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYREL 74
           V    F V  RY QL+ IG GA G+V +A+D V    VA+KK+S PF++QT+ +R  RE+
Sbjct: 31  VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 89

Query: 75  VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERMSYLLY 133
            +L    H+N+I + ++     TLE  +DVY+V +LM+ +L +++   +L ++ + Y LY
Sbjct: 90  QILLRFRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 148

Query: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF----MMTPYVVTR 189
           Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A         +T YV TR
Sbjct: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208

Query: 190 YYRAPEVIL-GMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEF 248
           +YRAPE++L   GY +++DIWSVGCI+AEM+ ++ +FPG+ Y+DQ N ++  LG+PS E 
Sbjct: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268

Query: 249 MK-KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
           +   +    RNY+++ P    + + +LFP               S+A DLL +ML  +P+
Sbjct: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPK------------SDSKALDLLDRMLTFNPN 316

Query: 308 KRISVDEALRHPYITVWYDPAEAEAPPP 335
           KRI+V+EAL HPY+  +YDP +     P
Sbjct: 317 KRITVEEALAHPYLEQYYDPTDEVGQSP 344


>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
           sapiens]
          Length = 816

 Score =  255 bits (652), Expect = 5e-68
 Identities = 149/380 (39%), Positives = 224/380 (58%), Gaps = 28/380 (7%)

Query: 17  DSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVL 76
           D TF V   Y+ ++ IG+GA G+V +A   + G  VA+KK+   F   T+AKR  REL +
Sbjct: 46  DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105

Query: 77  LKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH--MELDHERMSYLLYQ 134
           LK   H NII++ ++  P     EF+ VY+V++LM+++L Q+IH    L  E + Y LYQ
Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165

Query: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTN-----FMMTPYVVTR 189
           +L G+K++HSA +IHRDLKPSN++V  +C LKI DFG+AR  CT+     + MT YV TR
Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225

Query: 190 YYRAPEVILGM-GYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEF 248
           +YRAPE++L +  Y + +D+WSVGCI  EM+  + LFPG++Y+ Q   ++  LGTPS   
Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285

Query: 249 MKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
           ++ +    VR Y+++ P    + +E ++P                QA  LL +ML  +P 
Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPG------------ADRQALSLLGRMLRFEPS 333

Query: 308 KRISVDEALRHPYITVWYDP-AEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEER 366
            RIS   ALRHP++  ++DP  E +  PP  +D   +      E  KE I  E+ D+  R
Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPP--FDFAFDREALTRERIKEAIVAEIEDFHAR 391

Query: 367 SKNGV---VKDQPSDAAVSS 383
            + G+   ++ QPS   V+S
Sbjct: 392 -REGIRQQIRFQPSLQPVAS 410


>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
           sapiens]
          Length = 816

 Score =  255 bits (652), Expect = 5e-68
 Identities = 149/380 (39%), Positives = 224/380 (58%), Gaps = 28/380 (7%)

Query: 17  DSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVL 76
           D TF V   Y+ ++ IG+GA G+V +A   + G  VA+KK+   F   T+AKR  REL +
Sbjct: 46  DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105

Query: 77  LKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH--MELDHERMSYLLYQ 134
           LK   H NII++ ++  P     EF+ VY+V++LM+++L Q+IH    L  E + Y LYQ
Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165

Query: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTN-----FMMTPYVVTR 189
           +L G+K++HSA +IHRDLKPSN++V  +C LKI DFG+AR  CT+     + MT YV TR
Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225

Query: 190 YYRAPEVILGM-GYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEF 248
           +YRAPE++L +  Y + +D+WSVGCI  EM+  + LFPG++Y+ Q   ++  LGTPS   
Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285

Query: 249 MKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
           ++ +    VR Y+++ P    + +E ++P                QA  LL +ML  +P 
Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPG------------ADRQALSLLGRMLRFEPS 333

Query: 308 KRISVDEALRHPYITVWYDP-AEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEER 366
            RIS   ALRHP++  ++DP  E +  PP  +D   +      E  KE I  E+ D+  R
Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPP--FDFAFDREALTRERIKEAIVAEIEDFHAR 391

Query: 367 SKNGV---VKDQPSDAAVSS 383
            + G+   ++ QPS   V+S
Sbjct: 392 -REGIRQQIRFQPSLQPVAS 410


>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
           sapiens]
          Length = 816

 Score =  255 bits (652), Expect = 5e-68
 Identities = 149/380 (39%), Positives = 224/380 (58%), Gaps = 28/380 (7%)

Query: 17  DSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVL 76
           D TF V   Y+ ++ IG+GA G+V +A   + G  VA+KK+   F   T+AKR  REL +
Sbjct: 46  DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105

Query: 77  LKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH--MELDHERMSYLLYQ 134
           LK   H NII++ ++  P     EF+ VY+V++LM+++L Q+IH    L  E + Y LYQ
Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165

Query: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTN-----FMMTPYVVTR 189
           +L G+K++HSA +IHRDLKPSN++V  +C LKI DFG+AR  CT+     + MT YV TR
Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225

Query: 190 YYRAPEVILGM-GYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEF 248
           +YRAPE++L +  Y + +D+WSVGCI  EM+  + LFPG++Y+ Q   ++  LGTPS   
Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285

Query: 249 MKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
           ++ +    VR Y+++ P    + +E ++P                QA  LL +ML  +P 
Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPG------------ADRQALSLLGRMLRFEPS 333

Query: 308 KRISVDEALRHPYITVWYDP-AEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEER 366
            RIS   ALRHP++  ++DP  E +  PP  +D   +      E  KE I  E+ D+  R
Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPP--FDFAFDREALTRERIKEAIVAEIEDFHAR 391

Query: 367 SKNGV---VKDQPSDAAVSS 383
            + G+   ++ QPS   V+S
Sbjct: 392 -REGIRQQIRFQPSLQPVAS 410


>gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo
           sapiens]
          Length = 335

 Score =  218 bits (555), Expect = 8e-57
 Identities = 133/352 (37%), Positives = 197/352 (55%), Gaps = 66/352 (18%)

Query: 15  VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYREL 74
           V    F V  RY QL+ IG GA G+V +A+D V    VA+KK+S PF++QT+ +R  RE+
Sbjct: 31  VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 89

Query: 75  VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERMSYLLY 133
            +L    H+N+I + ++     TLE  +DVY+V +LM+ +L +++   +L ++ + Y LY
Sbjct: 90  QILLRFRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 148

Query: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF----MMTPYVVTR 189
           Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A         +T YV TR
Sbjct: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208

Query: 190 YYRAPEVILGM-GYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEF 248
           +YRAPE++L   GY +++DIWSVGCI+AEM+                             
Sbjct: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEML----------------------------- 239

Query: 249 MKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDK 308
                        NRP              IFP +   D++    A DLL +ML  +P+K
Sbjct: 240 ------------SNRP--------------IFPGKHYLDQLNHILALDLLDRMLTFNPNK 273

Query: 309 RISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKE 359
           RI+V+EAL HPY+  +YDP  E  A  P  +  +L++     E  KELI++E
Sbjct: 274 RITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 323


>gi|149408126 nemo like kinase [Homo sapiens]
          Length = 527

 Score =  211 bits (536), Expect = 1e-54
 Identities = 122/298 (40%), Positives = 180/298 (60%), Gaps = 18/298 (6%)

Query: 30  KPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLL 89
           +PIG GA G+V +  D   G  VA+KK+   FQN    KR +REL +L    H N++S L
Sbjct: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201

Query: 90  NVFTPQKTLEEFQDVYLVMELMDANLCQVI--HMELDHERMSYLLYQMLCGIKHLHSAGI 147
           ++  P   ++ F+++Y+V ELM ++L ++I     L  + +   LYQ+L G+K+LHSAGI
Sbjct: 202 DILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260

Query: 148 IHRDLKPSNIVVKSDCTLKILDFGLART--ACTNFMMTPYVVTRYYRAPEVILGMGYKEN 205
           +HRD+KP N++V S+C LKI DFGLAR      +  MT  VVT+YYRAPE+++G  +  N
Sbjct: 261 LHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSN 320

Query: 206 -VDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRP 264
            +DIWSVGCI AE++  ++LF  +  I Q + + + LGTPS E M+      + ++   P
Sbjct: 321 AIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGP 380

Query: 265 -KYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI 321
            K P +         ++   S+     T +A  LL +MLV DP KRIS  +AL HPY+
Sbjct: 381 HKQPSLPV-------LYTLSSQ----ATHEAVHLLCRMLVFDPSKRISAKDALAHPYL 427


>gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]
          Length = 544

 Score =  198 bits (503), Expect = 9e-51
 Identities = 123/355 (34%), Positives = 202/355 (56%), Gaps = 32/355 (9%)

Query: 22  VLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCV- 80
           +++RY   + +G GA GIV  A D   G  VA+KK+   F+++T A+R +RE+ LL+   
Sbjct: 9   IVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG 68

Query: 81  NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME--LDHERMSYLLYQMLCG 138
           +H NIISLL+V       E  +D+YLV E MD +L  VI     L    +  + YQ+L  
Sbjct: 69  DHPNIISLLDVIRA----ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRA 124

Query: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART------ACTNFMMTPYVVTRYYR 192
            + LHS  ++HRD KPSN+++ ++CT+K+ DFGLAR+         +  +T YV TR+YR
Sbjct: 125 TRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYR 184

Query: 193 APEVILGM-GYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFMKK 251
           APEV+L    Y   VD+WS+GCI+ EM+  + LFPG   + Q   ++E +  PS E +  
Sbjct: 185 APEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLA 244

Query: 252 L----QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
           L    + +V + + +RP+           D + P ++      + +A DLL ++LV  PD
Sbjct: 245 LGSGCRASVLHQLGSRPRQT--------LDALLPPDT------SPEALDLLRRLLVFAPD 290

Query: 308 KRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMD 362
           KR+S  +AL+HPY+  ++ P++  A    +     E  + ++ E++  +Y+ +++
Sbjct: 291 KRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILE 345


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.133    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,195,542
Number of Sequences: 37866
Number of extensions: 710242
Number of successful extensions: 4690
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 761
Number of HSP's successfully gapped in prelim test: 68
Number of HSP's that attempted gapping in prelim test: 2297
Number of HSP's gapped (non-prelim): 1337
length of query: 424
length of database: 18,247,518
effective HSP length: 105
effective length of query: 319
effective length of database: 14,271,588
effective search space: 4552636572
effective search space used: 4552636572
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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