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Search of human proteins with 21237739
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21237739 mitogen-activated protein kinase 9 isoform JNK2
alpha1 [Homo sapiens]
(382 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alph... 780 0.0
gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alph... 771 0.0
gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta... 759 0.0
gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta... 750 0.0
gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo s... 669 0.0
gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo ... 667 0.0
gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo ... 667 0.0
gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta... 665 0.0
gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta... 662 0.0
gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha... 654 0.0
gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alph... 651 0.0
gi|20986508 mitogen-activated protein kinase 10 isoform 4 [Homo ... 482 e-136
gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gam... 467 e-132
gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ... 335 5e-92
gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo s... 325 4e-89
gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens] 322 5e-88
gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens] 321 6e-88
gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens] 316 3e-86
gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo ... 287 1e-77
gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo ... 277 1e-74
gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens] 256 2e-68
gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens] 256 2e-68
gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s... 254 1e-67
gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s... 248 5e-66
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s... 247 1e-65
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ... 247 1e-65
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ... 247 1e-65
gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo ... 215 5e-56
gi|149408126 nemo like kinase [Homo sapiens] 209 3e-54
gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens] 200 2e-51
>gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alpha1
[Homo sapiens]
Length = 382
Score = 780 bits (2015), Expect = 0.0
Identities = 382/382 (100%), Positives = 382/382 (100%)
Query: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP
Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
Query: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH
Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240
Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK
Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV
Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
Query: 361 MDWEERSKNGVVKDQPSAQMQQ 382
MDWEERSKNGVVKDQPSAQMQQ
Sbjct: 361 MDWEERSKNGVVKDQPSAQMQQ 382
>gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alpha2
[Homo sapiens]
Length = 424
Score = 771 bits (1991), Expect = 0.0
Identities = 377/377 (100%), Positives = 377/377 (100%)
Query: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP
Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
Query: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH
Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240
Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK
Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV
Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
Query: 361 MDWEERSKNGVVKDQPS 377
MDWEERSKNGVVKDQPS
Sbjct: 361 MDWEERSKNGVVKDQPS 377
>gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta1
[Homo sapiens]
Length = 382
Score = 759 bits (1960), Expect = 0.0
Identities = 373/382 (97%), Positives = 376/382 (98%)
Query: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP
Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
Query: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH
Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM E+V V+F G D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240
Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK
Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV
Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
Query: 361 MDWEERSKNGVVKDQPSAQMQQ 382
MDWEERSKNGVVKDQPSAQMQQ
Sbjct: 361 MDWEERSKNGVVKDQPSAQMQQ 382
>gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta2
[Homo sapiens]
Length = 424
Score = 750 bits (1936), Expect = 0.0
Identities = 368/377 (97%), Positives = 371/377 (98%)
Query: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP
Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
Query: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH
Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM E+V V+F G D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240
Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK
Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV
Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
Query: 361 MDWEERSKNGVVKDQPS 377
MDWEERSKNGVVKDQPS
Sbjct: 361 MDWEERSKNGVVKDQPS 377
>gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo
sapiens]
Length = 422
Score = 669 bits (1727), Expect = 0.0
Identities = 329/384 (85%), Positives = 354/384 (92%), Gaps = 2/384 (0%)
Query: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
MS SK D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL NVA+KKLSRP
Sbjct: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98
Query: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
FQNQTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI
Sbjct: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158
Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218
Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE+V+ ++F G D+IDQWNKVIEQ
Sbjct: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278
Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
LGTP EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338
Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
MLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH IEEWKELIYKEV
Sbjct: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398
Query: 361 MDWEERSKNGVVKDQ--PSAQMQQ 382
M+ EE++KNGVVK Q PSAQ+QQ
Sbjct: 399 MNSEEKTKNGVVKGQPSPSAQVQQ 422
>gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo
sapiens]
Length = 464
Score = 667 bits (1720), Expect = 0.0
Identities = 325/377 (86%), Positives = 349/377 (92%)
Query: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
MS SK D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL NVA+KKLSRP
Sbjct: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98
Query: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
FQNQTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI
Sbjct: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158
Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218
Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE+V+ ++F G D+IDQWNKVIEQ
Sbjct: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278
Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
LGTP EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338
Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
MLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH IEEWKELIYKEV
Sbjct: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398
Query: 361 MDWEERSKNGVVKDQPS 377
M+ EE++KNGVVK QPS
Sbjct: 399 MNSEEKTKNGVVKGQPS 415
>gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo
sapiens]
Length = 426
Score = 667 bits (1720), Expect = 0.0
Identities = 325/377 (86%), Positives = 349/377 (92%)
Query: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
MS SK D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL NVA+KKLSRP
Sbjct: 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 60
Query: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
FQNQTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI
Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 120
Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE+V+ ++F G D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 240
Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
LGTP EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 300
Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
MLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 360
Query: 361 MDWEERSKNGVVKDQPS 377
M+ EE++KNGVVK QPS
Sbjct: 361 MNSEEKTKNGVVKGQPS 377
>gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta1
[Homo sapiens]
Length = 384
Score = 665 bits (1716), Expect = 0.0
Identities = 325/384 (84%), Positives = 352/384 (91%), Gaps = 2/384 (0%)
Query: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L NVA+KKLSRP
Sbjct: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
Query: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI
Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE++KG V+F GTDHIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240
Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
LGTP EFMKKLQPTVR YVENRPKY G FE+LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
MLVID KRISVDEAL+HPYI VWYDP+EAEAPPP+I D QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
Query: 361 MDWEERSKNGVVKDQPS--AQMQQ 382
MD EER+KNGV++ QPS AQ+QQ
Sbjct: 361 MDLEERTKNGVIRGQPSPLAQVQQ 384
>gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta2
[Homo sapiens]
Length = 427
Score = 662 bits (1709), Expect = 0.0
Identities = 321/377 (85%), Positives = 347/377 (92%)
Query: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L NVA+KKLSRP
Sbjct: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
Query: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI
Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE++KG V+F GTDHIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240
Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
LGTP EFMKKLQPTVR YVENRPKY G FE+LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
MLVID KRISVDEAL+HPYI VWYDP+EAEAPPP+I D QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
Query: 361 MDWEERSKNGVVKDQPS 377
MD EER+KNGV++ QPS
Sbjct: 361 MDLEERTKNGVIRGQPS 377
>gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha1
[Homo sapiens]
Length = 384
Score = 654 bits (1686), Expect = 0.0
Identities = 320/384 (83%), Positives = 349/384 (90%), Gaps = 2/384 (0%)
Query: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L NVA+KKLSRP
Sbjct: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
Query: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI
Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240
MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIMGE+V ++F G D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240
Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
LGTP EFMKKLQPTVR YVENRPKY G FE+LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
MLVID KRISVDEAL+HPYI VWYDP+EAEAPPP+I D QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
Query: 361 MDWEERSKNGVVKDQPS--AQMQQ 382
MD EER+KNGV++ QPS AQ+QQ
Sbjct: 361 MDLEERTKNGVIRGQPSPLAQVQQ 384
>gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alpha2
[Homo sapiens]
Length = 427
Score = 651 bits (1679), Expect = 0.0
Identities = 316/377 (83%), Positives = 344/377 (91%)
Query: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L NVA+KKLSRP
Sbjct: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
Query: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI
Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240
MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIMGE+V ++F G D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240
Query: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
LGTP EFMKKLQPTVR YVENRPKY G FE+LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
Query: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
MLVID KRISVDEAL+HPYI VWYDP+EAEAPPP+I D QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
Query: 361 MDWEERSKNGVVKDQPS 377
MD EER+KNGV++ QPS
Sbjct: 361 MDLEERTKNGVIRGQPS 377
>gi|20986508 mitogen-activated protein kinase 10 isoform 4 [Homo
sapiens]
Length = 277
Score = 482 bits (1240), Expect = e-136
Identities = 234/277 (84%), Positives = 254/277 (91%), Gaps = 2/277 (0%)
Query: 108 MELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 167
MELMDANLCQVI MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI
Sbjct: 1 MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60
Query: 168 LDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQG 227
LDFGLARTA T+FMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE+V+ ++F G
Sbjct: 61 LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 120
Query: 228 TDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERD 287
D+IDQWNKVIEQLGTP EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +
Sbjct: 121 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 180
Query: 288 KIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREH 347
K+K SQARDLLSKMLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH
Sbjct: 181 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 240
Query: 348 AIEEWKELIYKEVMDWEERSKNGVVKDQ--PSAQMQQ 382
IEEWKELIYKEVM+ EE++KNGVVK Q PSAQ+QQ
Sbjct: 241 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSAQVQQ 277
>gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gamma
[Homo sapiens]
Length = 242
Score = 467 bits (1201), Expect = e-132
Identities = 230/231 (99%), Positives = 230/231 (99%)
Query: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP
Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
Query: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH
Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHI 231
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTD I
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDRI 231
>gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo
sapiens]
Length = 360
Score = 335 bits (858), Expect = 5e-92
Identities = 179/357 (50%), Positives = 235/357 (65%), Gaps = 19/357 (5%)
Query: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
FY ++ + + V +RYQ L P+GSGA G VCAAFDT G+ VAVKKLSRPFQ+ HAKR
Sbjct: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
Query: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128
YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV LM A+L ++ +L + +
Sbjct: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
Query: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188
+L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T+ MT YV T
Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185
Query: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAE 247
R+YRAPE++L M Y + VDIWSVGCIM EL+ G +F GTDHIDQ ++ +GTP AE
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245
Query: 248 FMKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 306
+KK+ + RNY+++ + P + F +F A DLL KMLV+D
Sbjct: 246 LLKKISSESARNYIQSLTQMPKMNFANVFIG------------ANPLAVDLLEKMLVLDS 293
Query: 307 DKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDW 363
DKRI+ +AL H Y ++DP + P YD E R+ I+EWK L Y EV+ +
Sbjct: 294 DKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRDLLIDEWKSLTYDEVISF 348
>gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo
sapiens]
Length = 360
Score = 325 bits (833), Expect = 4e-89
Identities = 175/357 (49%), Positives = 232/357 (64%), Gaps = 19/357 (5%)
Query: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
FY ++ + + V +RYQ L P+GSGA G VCAAFDT G+ VAVKKLSRPFQ+ HAKR
Sbjct: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
Query: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128
YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV LM A+L ++ +L + +
Sbjct: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
Query: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188
+L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T+ MT YV T
Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185
Query: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAE 247
R+YRAPE++L M Y + VDIWSVGCIM EL+ G +F GTDHI+Q +++ GTP A
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAY 245
Query: 248 FMKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 306
+ ++ RNY+++ + P + F +F A DLL KMLV+D
Sbjct: 246 LINRMPSHEARNYIQSLTQMPKMNFANVFIG------------ANPLAVDLLEKMLVLDS 293
Query: 307 DKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDW 363
DKRI+ +AL H Y ++DP + P YD E R+ I+EWK L Y EV+ +
Sbjct: 294 DKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRDLLIDEWKSLTYDEVISF 348
>gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]
Length = 365
Score = 322 bits (824), Expect = 5e-88
Identities = 168/356 (47%), Positives = 233/356 (65%), Gaps = 17/356 (4%)
Query: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
FY V + + + K Y +GSGA G VC+A D G VA+KKLSRPFQ++ AKR
Sbjct: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68
Query: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMS 129
AYREL+LLK + H+N+I LL+VFTP +L F D YLVM M +L +++ ME E++
Sbjct: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQ 128
Query: 130 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTR 189
YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A + MT YVVTR
Sbjct: 129 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEMTGYVVTR 186
Query: 190 YYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEF 248
+YRAPEVIL M Y + VDIWSVGCIM E++ G +F+G D++DQ ++++ G P EF
Sbjct: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246
Query: 249 MKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
++KL ++Y+++ P+ P F +LFP + QA DLL KML +D D
Sbjct: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPR------------ASPQAADLLEKMLELDVD 294
Query: 308 KRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDW 363
KR++ +AL HP+ + DP E E Q +D LE + ++EWK+ IYKE++++
Sbjct: 295 KRLTAAQALTHPFFEPFRDP-EEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNF 349
>gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
Length = 364
Score = 321 bits (823), Expect = 6e-88
Identities = 172/359 (47%), Positives = 239/359 (66%), Gaps = 21/359 (5%)
Query: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
FY ++ + + V +R Q L+P+GSGA G VC+A+D L VAVKKLSRPFQ+ HA+R
Sbjct: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67
Query: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERM 128
YREL LLK + H+N+I LL+VFTP ++E+F +VYLV LM A+L ++ + L E +
Sbjct: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127
Query: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188
+L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A + MT YV T
Sbjct: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA--DEEMTGYVAT 185
Query: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAE 247
R+YRAPE++L M Y + VDIWSVGCIM EL++G +F G+D+IDQ +++E +GTPS E
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245
Query: 248 FMKKLQPT-VRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 306
+ K+ R Y+++ P P +F + A DLL +MLV+D
Sbjct: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIF------------RGANPLAIDLLGRMLVLDS 293
Query: 307 DKRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWE 364
D+R+S EAL H Y + ++DP E EA P YD +E +E +EEWKEL Y+EV+ ++
Sbjct: 294 DQRVSAAEALAHAYFSQYHDPEDEPEAEP---YDESVEAKERTLEEWKELTYQEVLSFK 349
>gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]
Length = 367
Score = 316 bits (809), Expect = 3e-86
Identities = 170/374 (45%), Positives = 244/374 (65%), Gaps = 21/374 (5%)
Query: 8 SQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHA 67
S FY +V + + V Y+ L+P+GSGA G VC+A D G VA+KKL RPFQ++ A
Sbjct: 9 SGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA 68
Query: 68 KRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI-HMELDHE 126
KRAYREL LLK + H+N+I LL+VFTP +TL++F D YLVM M +L +++ H +L +
Sbjct: 69 KRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED 128
Query: 127 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYV 186
R+ +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT YV
Sbjct: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYV 186
Query: 187 VTRYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPS 245
VTR+YRAPEVIL M Y + VDIWSVGCIM E++ G +F+G+DH+DQ ++++ GTP
Sbjct: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246
Query: 246 AEFMKKLQ-PTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVI 304
AEF+++LQ +NY++ P+ F + + + A +LL KMLV+
Sbjct: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTN------------ASPLAVNLLEKMLVL 294
Query: 305 DPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWE 364
D ++R++ EAL HPY +D + P Q YD ++ + ++EWK + YKEV+ ++
Sbjct: 295 DAEQRVTAGEALAHPYFESLHD--TEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFK 352
Query: 365 ERSKNG--VVKDQP 376
+ G V K+ P
Sbjct: 353 PPRQLGARVSKETP 366
>gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo
sapiens]
Length = 297
Score = 287 bits (735), Expect = 1e-77
Identities = 147/269 (54%), Positives = 193/269 (71%), Gaps = 5/269 (1%)
Query: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
FY ++ + + V +RYQ L P+GSGA G VCAAFDT G+ VAVKKLSRPFQ+ HAKR
Sbjct: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
Query: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128
YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV LM A+L ++ +L + +
Sbjct: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
Query: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188
+L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T+ MT YV T
Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185
Query: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAE 247
R+YRAPE++L M Y + VDIWSVGCIM EL+ G +F GTDHIDQ ++ +GTP AE
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245
Query: 248 FMKKL-QPTVRNYVENRPKYPGIKFEELF 275
+KK+ + RNY+++ + P + F +F
Sbjct: 246 LLKKISSESARNYIQSLTQMPKMNFANVF 274
>gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo
sapiens]
Length = 307
Score = 277 bits (708), Expect = 1e-74
Identities = 141/245 (57%), Positives = 180/245 (73%), Gaps = 4/245 (1%)
Query: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
FY ++ + + V +RYQ L P+GSGA G VCAAFDT G+ VAVKKLSRPFQ+ HAKR
Sbjct: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
Query: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128
YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV LM A+L ++ +L + +
Sbjct: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
Query: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188
+L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T+ MT YV T
Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185
Query: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAE 247
R+YRAPE++L M Y + VDIWSVGCIM EL+ G +F GTDHIDQ ++ +GTP AE
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245
Query: 248 FMKKL 252
+KK+
Sbjct: 246 LLKKI 250
>gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 256 bits (654), Expect = 2e-68
Identities = 144/353 (40%), Positives = 221/353 (62%), Gaps = 24/353 (6%)
Query: 15 VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYREL 74
V F V RY L IG GA G+VC+A+D V + VA+KK+S PF++QT+ +R RE+
Sbjct: 14 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREI 72
Query: 75 VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERMSYLLY 133
+L H+NII + ++ T+E+ +DVY+V +LM+ +L +++ + L ++ + Y LY
Sbjct: 73 KILLRFRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 131
Query: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF----MMTPYVVTR 189
Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A + +T YV TR
Sbjct: 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 191
Query: 190 YYRAPEVIL-GMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEF 248
+YRAPE++L GY +++DIWSVGCI+ E++ IF G ++DQ N ++ LG+PS E
Sbjct: 192 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251
Query: 249 MK-KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
+ + RNY+ + P + + LFP+ S+A DLL KML +P
Sbjct: 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPN------------ADSKALDLLDKMLTFNPH 299
Query: 308 KRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKE 359
KRI V++AL HPY+ +YDP+ E A P +D +L++ E+ KELI++E
Sbjct: 300 KRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350
>gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 256 bits (654), Expect = 2e-68
Identities = 144/353 (40%), Positives = 221/353 (62%), Gaps = 24/353 (6%)
Query: 15 VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYREL 74
V F V RY L IG GA G+VC+A+D V + VA+KK+S PF++QT+ +R RE+
Sbjct: 14 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREI 72
Query: 75 VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERMSYLLY 133
+L H+NII + ++ T+E+ +DVY+V +LM+ +L +++ + L ++ + Y LY
Sbjct: 73 KILLRFRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 131
Query: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF----MMTPYVVTR 189
Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A + +T YV TR
Sbjct: 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 191
Query: 190 YYRAPEVIL-GMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEF 248
+YRAPE++L GY +++DIWSVGCI+ E++ IF G ++DQ N ++ LG+PS E
Sbjct: 192 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251
Query: 249 MK-KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
+ + RNY+ + P + + LFP+ S+A DLL KML +P
Sbjct: 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPN------------ADSKALDLLDKMLTFNPH 299
Query: 308 KRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKE 359
KRI V++AL HPY+ +YDP+ E A P +D +L++ E+ KELI++E
Sbjct: 300 KRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350
>gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo
sapiens]
Length = 379
Score = 254 bits (648), Expect = 1e-67
Identities = 143/353 (40%), Positives = 219/353 (62%), Gaps = 24/353 (6%)
Query: 15 VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYREL 74
V F V RY QL+ IG GA G+V +A+D V VA+KK+S PF++QT+ +R RE+
Sbjct: 31 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 89
Query: 75 VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERMSYLLY 133
+L H+N+I + ++ TLE +DVY+V +LM+ +L +++ +L ++ + Y LY
Sbjct: 90 QILLRFRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 148
Query: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF----MMTPYVVTR 189
Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR
Sbjct: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208
Query: 190 YYRAPEVIL-GMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEF 248
+YRAPE++L GY +++DIWSVGCI+ E++ IF G ++DQ N ++ LG+PS E
Sbjct: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268
Query: 249 MK-KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
+ + RNY+++ P + + +LFP S+A DLL +ML +P+
Sbjct: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPK------------SDSKALDLLDRMLTFNPN 316
Query: 308 KRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKE 359
KRI+V+EAL HPY+ +YDP E A P + +L++ E KELI++E
Sbjct: 317 KRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 367
>gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo
sapiens]
Length = 357
Score = 248 bits (634), Expect = 5e-66
Identities = 134/328 (40%), Positives = 205/328 (62%), Gaps = 21/328 (6%)
Query: 15 VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYREL 74
V F V RY QL+ IG GA G+V +A+D V VA+KK+S PF++QT+ +R RE+
Sbjct: 31 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 89
Query: 75 VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERMSYLLY 133
+L H+N+I + ++ TLE +DVY+V +LM+ +L +++ +L ++ + Y LY
Sbjct: 90 QILLRFRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 148
Query: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF----MMTPYVVTR 189
Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR
Sbjct: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208
Query: 190 YYRAPEVIL-GMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEF 248
+YRAPE++L GY +++DIWSVGCI+ E++ IF G ++DQ N ++ LG+PS E
Sbjct: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268
Query: 249 MK-KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
+ + RNY+++ P + + +LFP S+A DLL +ML +P+
Sbjct: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPK------------SDSKALDLLDRMLTFNPN 316
Query: 308 KRISVDEALRHPYITVWYDPAEAEAPPP 335
KRI+V+EAL HPY+ +YDP + P
Sbjct: 317 KRITVEEALAHPYLEQYYDPTDEVGQSP 344
>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 247 bits (631), Expect = 1e-65
Identities = 145/376 (38%), Positives = 220/376 (58%), Gaps = 28/376 (7%)
Query: 17 DSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVL 76
D TF V Y+ ++ IG+GA G+V +A + G VA+KK+ F T+AKR REL +
Sbjct: 46 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105
Query: 77 LKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH--MELDHERMSYLLYQ 134
LK H NII++ ++ P EF+ VY+V++LM+++L Q+IH L E + Y LYQ
Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165
Query: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTN-----FMMTPYVVTR 189
+L G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR CT+ + MT YV TR
Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225
Query: 190 YYRAPEVILGM-GYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEF 248
+YRAPE++L + Y + +D+WSVGCI GE++ +F G +++ Q ++ LGTPS
Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285
Query: 249 MKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
++ + VR Y+++ P + +E ++P QA LL +ML +P
Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPG------------ADRQALSLLGRMLRFEPS 333
Query: 308 KRISVDEALRHPYITVWYDP-AEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEER 366
RIS ALRHP++ ++DP E + PP +D + E KE I E+ D+ R
Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPP--FDFAFDREALTRERIKEAIVAEIEDFHAR 391
Query: 367 SKNGV---VKDQPSAQ 379
+ G+ ++ QPS Q
Sbjct: 392 -REGIRQQIRFQPSLQ 406
>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 247 bits (631), Expect = 1e-65
Identities = 145/376 (38%), Positives = 220/376 (58%), Gaps = 28/376 (7%)
Query: 17 DSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVL 76
D TF V Y+ ++ IG+GA G+V +A + G VA+KK+ F T+AKR REL +
Sbjct: 46 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105
Query: 77 LKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH--MELDHERMSYLLYQ 134
LK H NII++ ++ P EF+ VY+V++LM+++L Q+IH L E + Y LYQ
Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165
Query: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTN-----FMMTPYVVTR 189
+L G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR CT+ + MT YV TR
Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225
Query: 190 YYRAPEVILGM-GYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEF 248
+YRAPE++L + Y + +D+WSVGCI GE++ +F G +++ Q ++ LGTPS
Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285
Query: 249 MKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
++ + VR Y+++ P + +E ++P QA LL +ML +P
Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPG------------ADRQALSLLGRMLRFEPS 333
Query: 308 KRISVDEALRHPYITVWYDP-AEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEER 366
RIS ALRHP++ ++DP E + PP +D + E KE I E+ D+ R
Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPP--FDFAFDREALTRERIKEAIVAEIEDFHAR 391
Query: 367 SKNGV---VKDQPSAQ 379
+ G+ ++ QPS Q
Sbjct: 392 -REGIRQQIRFQPSLQ 406
>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 247 bits (631), Expect = 1e-65
Identities = 145/376 (38%), Positives = 220/376 (58%), Gaps = 28/376 (7%)
Query: 17 DSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVL 76
D TF V Y+ ++ IG+GA G+V +A + G VA+KK+ F T+AKR REL +
Sbjct: 46 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105
Query: 77 LKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH--MELDHERMSYLLYQ 134
LK H NII++ ++ P EF+ VY+V++LM+++L Q+IH L E + Y LYQ
Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165
Query: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTN-----FMMTPYVVTR 189
+L G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR CT+ + MT YV TR
Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225
Query: 190 YYRAPEVILGM-GYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEF 248
+YRAPE++L + Y + +D+WSVGCI GE++ +F G +++ Q ++ LGTPS
Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285
Query: 249 MKKL-QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
++ + VR Y+++ P + +E ++P QA LL +ML +P
Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPG------------ADRQALSLLGRMLRFEPS 333
Query: 308 KRISVDEALRHPYITVWYDP-AEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEER 366
RIS ALRHP++ ++DP E + PP +D + E KE I E+ D+ R
Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPP--FDFAFDREALTRERIKEAIVAEIEDFHAR 391
Query: 367 SKNGV---VKDQPSAQ 379
+ G+ ++ QPS Q
Sbjct: 392 -REGIRQQIRFQPSLQ 406
>gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo
sapiens]
Length = 335
Score = 215 bits (548), Expect = 5e-56
Identities = 131/352 (37%), Positives = 196/352 (55%), Gaps = 66/352 (18%)
Query: 15 VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYREL 74
V F V RY QL+ IG GA G+V +A+D V VA+KK+S PF++QT+ +R RE+
Sbjct: 31 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 89
Query: 75 VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERMSYLLY 133
+L H+N+I + ++ TLE +DVY+V +LM+ +L +++ +L ++ + Y LY
Sbjct: 90 QILLRFRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 148
Query: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF----MMTPYVVTR 189
Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR
Sbjct: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208
Query: 190 YYRAPEVILGM-GYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEF 248
+YRAPE++L GY +++DIWSVGCI+ E++
Sbjct: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS---------------------------- 240
Query: 249 MKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDK 308
NRP IFP + D++ A DLL +ML +P+K
Sbjct: 241 -------------NRP--------------IFPGKHYLDQLNHILALDLLDRMLTFNPNK 273
Query: 309 RISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKE 359
RI+V+EAL HPY+ +YDP E A P + +L++ E KELI++E
Sbjct: 274 RITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 323
>gi|149408126 nemo like kinase [Homo sapiens]
Length = 527
Score = 209 bits (532), Expect = 3e-54
Identities = 122/298 (40%), Positives = 178/298 (59%), Gaps = 18/298 (6%)
Query: 30 KPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLL 89
+PIG GA G+V + D G VA+KK+ FQN KR +REL +L H N++S L
Sbjct: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201
Query: 90 NVFTPQKTLEEFQDVYLVMELMDANLCQVI--HMELDHERMSYLLYQMLCGIKHLHSAGI 147
++ P ++ F+++Y+V ELM ++L ++I L + + LYQ+L G+K+LHSAGI
Sbjct: 202 DILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260
Query: 148 IHRDLKPSNIVVKSDCTLKILDFGLART--ACTNFMMTPYVVTRYYRAPEVILGMGYKEN 205
+HRD+KP N++V S+C LKI DFGLAR + MT VVT+YYRAPE+++G + N
Sbjct: 261 LHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSN 320
Query: 206 -VDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRP 264
+DIWSVGCI EL+ ++FQ I Q + + + LGTPS E M+ + ++ P
Sbjct: 321 AIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGP 380
Query: 265 -KYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI 321
K P + ++ S+ T +A LL +MLV DP KRIS +AL HPY+
Sbjct: 381 HKQPSLPV-------LYTLSSQ----ATHEAVHLLCRMLVFDPSKRISAKDALAHPYL 427
>gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]
Length = 544
Score = 200 bits (509), Expect = 2e-51
Identities = 123/355 (34%), Positives = 204/355 (57%), Gaps = 32/355 (9%)
Query: 22 VLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCV- 80
+++RY + +G GA GIV A D G VA+KK+ F+++T A+R +RE+ LL+
Sbjct: 9 IVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG 68
Query: 81 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME--LDHERMSYLLYQMLCG 138
+H NIISLL+V E +D+YLV E MD +L VI L + + YQ+L
Sbjct: 69 DHPNIISLLDVIRA----ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRA 124
Query: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART------ACTNFMMTPYVVTRYYR 192
+ LHS ++HRD KPSN+++ ++CT+K+ DFGLAR+ + +T YV TR+YR
Sbjct: 125 TRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYR 184
Query: 193 APEVILGM-GYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKK 251
APEV+L Y VD+WS+GCI+GE+++G +F GT + Q ++E + PS E +
Sbjct: 185 APEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLA 244
Query: 252 L----QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
L + +V + + +RP+ D + P ++ + +A DLL ++LV PD
Sbjct: 245 LGSGCRASVLHQLGSRPRQT--------LDALLPPDT------SPEALDLLRRLLVFAPD 290
Query: 308 KRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMD 362
KR+S +AL+HPY+ ++ P++ A + E + ++ E++ +Y+ +++
Sbjct: 291 KRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILE 345
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,867,254
Number of Sequences: 37866
Number of extensions: 654328
Number of successful extensions: 3793
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 747
Number of HSP's successfully gapped in prelim test: 60
Number of HSP's that attempted gapping in prelim test: 1613
Number of HSP's gapped (non-prelim): 1103
length of query: 382
length of database: 18,247,518
effective HSP length: 104
effective length of query: 278
effective length of database: 14,309,454
effective search space: 3978028212
effective search space used: 3978028212
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.