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Search of human proteins with 21071014
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21071014 epidermal growth factor receptor pathway substrate
8-like protein 3 isoform c [Homo sapiens]
(563 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21071014 epidermal growth factor receptor pathway substrate 8... 1141 0.0
gi|21071016 epidermal growth factor receptor pathway substrate 8... 1125 0.0
gi|21071018 epidermal growth factor receptor pathway substrate 8... 1120 0.0
gi|21264616 epidermal growth factor receptor pathway substrate 8... 258 1e-68
gi|148539853 epidermal growth factor receptor pathway substrate ... 242 6e-64
gi|56682953 epidermal growth factor receptor pathway substrate 8... 218 1e-56
gi|148539855 epidermal growth factor receptor pathway substrate ... 168 1e-41
gi|52630427 NCK adaptor protein 2 isoform B [Homo sapiens] 53 7e-07
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 53 7e-07
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] 53 7e-07
gi|20149528 proline-serine-threonine phosphatase interacting pro... 52 2e-06
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 51 3e-06
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 49 1e-05
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 46 8e-05
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 45 1e-04
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 45 1e-04
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 45 1e-04
gi|39930351 dynamin binding protein [Homo sapiens] 45 2e-04
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 45 2e-04
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 45 2e-04
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 45 2e-04
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 45 2e-04
gi|148596974 TXK tyrosine kinase [Homo sapiens] 45 2e-04
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 44 3e-04
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 44 3e-04
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 44 3e-04
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 44 4e-04
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 44 4e-04
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 44 4e-04
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 44 4e-04
>gi|21071014 epidermal growth factor receptor pathway substrate
8-like protein 3 isoform c [Homo sapiens]
Length = 563
Score = 1141 bits (2951), Expect = 0.0
Identities = 563/563 (100%), Positives = 563/563 (100%)
Query: 1 MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMTCKQGSQRVQGPEDALQKLFEMDAQ 60
MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMTCKQGSQRVQGPEDALQKLFEMDAQ
Sbjct: 1 MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMTCKQGSQRVQGPEDALQKLFEMDAQ 60
Query: 61 GRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPG 120
GRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPG
Sbjct: 61 GRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPG 120
Query: 121 LPGTSTLLFQCQEVGAERLKTSLQKALEEELEQRPRLGGLQPGQDRWRGPAMERPLPMEQ 180
LPGTSTLLFQCQEVGAERLKTSLQKALEEELEQRPRLGGLQPGQDRWRGPAMERPLPMEQ
Sbjct: 121 LPGTSTLLFQCQEVGAERLKTSLQKALEEELEQRPRLGGLQPGQDRWRGPAMERPLPMEQ 180
Query: 181 ARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDPERDEE 240
ARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDPERDEE
Sbjct: 181 ARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDPERDEE 240
Query: 241 VLNHVLRDIELFMGKLEKAQAKTSRKKKFGKKNKDQGGLTQAQYIDCFQKIKHSFNLLGR 300
VLNHVLRDIELFMGKLEKAQAKTSRKKKFGKKNKDQGGLTQAQYIDCFQKIKHSFNLLGR
Sbjct: 241 VLNHVLRDIELFMGKLEKAQAKTSRKKKFGKKNKDQGGLTQAQYIDCFQKIKHSFNLLGR 300
Query: 301 LATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLTPKAINLLQSCLSPPESN 360
LATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLTPKAINLLQSCLSPPESN
Sbjct: 301 LATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLTPKAINLLQSCLSPPESN 360
Query: 361 LWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLPEPSSQAPLGYQDPVSLRPSSPKPAQ 420
LWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLPEPSSQAPLGYQDPVSLRPSSPKPAQ
Sbjct: 361 LWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLPEPSSQAPLGYQDPVSLRPSSPKPAQ 420
Query: 421 PALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILEPLQPG 480
PALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILEPLQPG
Sbjct: 421 PALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILEPLQPG 480
Query: 481 TPGTQGQSPSRVPMLRLSSRPEEVTDWLQAENFSTATVRTLGSLTGSQLLRIRPGELQML 540
TPGTQGQSPSRVPMLRLSSRPEEVTDWLQAENFSTATVRTLGSLTGSQLLRIRPGELQML
Sbjct: 481 TPGTQGQSPSRVPMLRLSSRPEEVTDWLQAENFSTATVRTLGSLTGSQLLRIRPGELQML 540
Query: 541 CPQEAPRILSRLEAVRRMLGISP 563
CPQEAPRILSRLEAVRRMLGISP
Sbjct: 541 CPQEAPRILSRLEAVRRMLGISP 563
>gi|21071016 epidermal growth factor receptor pathway substrate
8-like protein 3 isoform b [Homo sapiens]
Length = 593
Score = 1125 bits (2910), Expect = 0.0
Identities = 563/593 (94%), Positives = 563/593 (94%), Gaps = 30/593 (5%)
Query: 1 MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMTCKQGSQRVQGPEDALQKLFEMDAQ 60
MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMTCKQGSQRVQGPEDALQKLFEMDAQ
Sbjct: 1 MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMTCKQGSQRVQGPEDALQKLFEMDAQ 60
Query: 61 GRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPG 120
GRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPG
Sbjct: 61 GRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPG 120
Query: 121 LPGTSTLLFQCQEVGAERLKTSLQKALEEELEQRPRLGGLQPGQDRWRGPAMERPLPMEQ 180
LPGTSTLLFQCQEVGAERLKTSLQKALEEELEQRPRLGGLQPGQDRWRGPAMERPLPMEQ
Sbjct: 121 LPGTSTLLFQCQEVGAERLKTSLQKALEEELEQRPRLGGLQPGQDRWRGPAMERPLPMEQ 180
Query: 181 ARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDPERDEE 240
ARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDPERDEE
Sbjct: 181 ARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDPERDEE 240
Query: 241 VLNHVLRDIELFMGKLEKAQAKTSRKKKFGKKNKDQGGLTQAQYIDCFQKIKHSFNLLGR 300
VLNHVLRDIELFMGKLEKAQAKTSRKKKFGKKNKDQGGLTQAQYIDCFQKIKHSFNLLGR
Sbjct: 241 VLNHVLRDIELFMGKLEKAQAKTSRKKKFGKKNKDQGGLTQAQYIDCFQKIKHSFNLLGR 300
Query: 301 LATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLTPKAINLLQSCLSPPESN 360
LATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLTPKAINLLQSCLSPPESN
Sbjct: 301 LATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLTPKAINLLQSCLSPPESN 360
Query: 361 LWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLPEPSSQAPLGYQDPVSL--------- 411
LWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLPEPSSQAPLGYQDPVSL
Sbjct: 361 LWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLPEPSSQAPLGYQDPVSLRRGSHRLGS 420
Query: 412 ---------------------RPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVL 450
RPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVL
Sbjct: 421 TSHFPQEKTHNHDPQPGDPNSRPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVL 480
Query: 451 DHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSRPEEVTDWLQA 510
DHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSRPEEVTDWLQA
Sbjct: 481 DHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSRPEEVTDWLQA 540
Query: 511 ENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRMLGISP 563
ENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRMLGISP
Sbjct: 541 ENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRMLGISP 593
>gi|21071018 epidermal growth factor receptor pathway substrate
8-like protein 3 isoform a [Homo sapiens]
Length = 594
Score = 1120 bits (2898), Expect = 0.0
Identities = 563/594 (94%), Positives = 563/594 (94%), Gaps = 31/594 (5%)
Query: 1 MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMTCKQGSQRVQGPEDALQKLFEMDAQ 60
MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMTCKQGSQRVQGPEDALQKLFEMDAQ
Sbjct: 1 MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMTCKQGSQRVQGPEDALQKLFEMDAQ 60
Query: 61 GRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPG 120
GRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPG
Sbjct: 61 GRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPG 120
Query: 121 LPGTSTLLFQCQEVGAERLKTSLQKALEEELEQ-RPRLGGLQPGQDRWRGPAMERPLPME 179
LPGTSTLLFQCQEVGAERLKTSLQKALEEELEQ RPRLGGLQPGQDRWRGPAMERPLPME
Sbjct: 121 LPGTSTLLFQCQEVGAERLKTSLQKALEEELEQSRPRLGGLQPGQDRWRGPAMERPLPME 180
Query: 180 QARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDPERDE 239
QARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDPERDE
Sbjct: 181 QARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDPERDE 240
Query: 240 EVLNHVLRDIELFMGKLEKAQAKTSRKKKFGKKNKDQGGLTQAQYIDCFQKIKHSFNLLG 299
EVLNHVLRDIELFMGKLEKAQAKTSRKKKFGKKNKDQGGLTQAQYIDCFQKIKHSFNLLG
Sbjct: 241 EVLNHVLRDIELFMGKLEKAQAKTSRKKKFGKKNKDQGGLTQAQYIDCFQKIKHSFNLLG 300
Query: 300 RLATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLTPKAINLLQSCLSPPES 359
RLATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLTPKAINLLQSCLSPPES
Sbjct: 301 RLATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLTPKAINLLQSCLSPPES 360
Query: 360 NLWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLPEPSSQAPLGYQDPVSL-------- 411
NLWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLPEPSSQAPLGYQDPVSL
Sbjct: 361 NLWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLPEPSSQAPLGYQDPVSLRRGSHRLG 420
Query: 412 ----------------------RPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEV 449
RPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEV
Sbjct: 421 STSHFPQEKTHNHDPQPGDPNSRPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEV 480
Query: 450 LDHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSRPEEVTDWLQ 509
LDHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSRPEEVTDWLQ
Sbjct: 481 LDHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSRPEEVTDWLQ 540
Query: 510 AENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRMLGISP 563
AENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRMLGISP
Sbjct: 541 AENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRMLGISP 594
>gi|21264616 epidermal growth factor receptor pathway substrate
8-like protein 2 [Homo sapiens]
Length = 715
Score = 258 bits (658), Expect = 1e-68
Identities = 199/681 (29%), Positives = 314/681 (46%), Gaps = 138/681 (20%)
Query: 1 MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMT-CKQGSQRVQGPEDALQKLFEMDA 59
+++ S + ++ RK+YS + Q+ V+HL T S+ + +DA++KL ++ +
Sbjct: 24 VAKMSPKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKSEAITSVDDAIRKLVQLSS 83
Query: 60 QGRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEP 119
+ ++W+Q+++LQV D L+LLDIE++EEL+ + L ++Q LN Y S+L + Q+
Sbjct: 84 KEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQRSQTVLNQLRYPSVLLLVCQDS 143
Query: 120 GLPGTSTLLFQCQEVGAERLKTSLQKALEE-ELEQRPRLGGLQPGQDRWRGPAMERPLPM 178
F C EV AE + ++ AL + L ++ R L+ Q++ R
Sbjct: 144 EQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIR---------- 193
Query: 179 EQARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDP--- 235
Q + + P PP+ P +H SP R + P + P RR S E+P
Sbjct: 194 -QRQSILP--PPQGPAPIPFQHRGGDSPEAKNR-VGPQVP--LSEPGFRRRESQEEPRAV 247
Query: 236 -----ERDEEVLNHVLRDIELFMGKLEKAQA------KTSRKKKFGKKNKDQGGLT---- 280
E++ ++LN L DIE F+ +L+KA + + KK GKK +G LT
Sbjct: 248 LAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLTLRAR 307
Query: 281 ---QAQYIDCFQKIKHSFNLLGRLATWLKETSAPELVHILFKSLNFILARCPEAGLAAQV 337
+ ++IDCFQKIK + NLL +L ++ SA ELVH LF L+ I+ C +A V
Sbjct: 308 PPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSV 367
Query: 338 ISPLLTPKAINLLQSCLSPPESNLWMGLGPAWTTSRADWTGDEPLP-YQPTFSDDWQLP- 395
PLL+ A++ L+ L P E +LW LG +W R++W + +P Y P F W+ P
Sbjct: 368 SCPLLSRDAVDFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPV 427
Query: 396 ----------EPSSQAPLGYQDPVSLR-------------PSSPKPAQP----------- 421
E + AP+ PVS + P+ P A P
Sbjct: 428 DVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPHTHRGY 487
Query: 422 ------ALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNIL- 474
A +++LY+F ARN EL+V++ E LEVL+ ++WW +++ +G++GY+P NIL
Sbjct: 488 QPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILG 547
Query: 475 -------------------------EPLQPGTPG------------------------TQ 485
L P PG Q
Sbjct: 548 EARPEDAGAPFEQAGQKYWGPASPTHKLPPSFPGNKDELMQHMDEVNDELIRKISNIRAQ 607
Query: 486 GQSPSRVPMLRLSSRP-------EEVTDWLQAENFSTATVRTLGSLTGSQLLRIRPGELQ 538
Q RV + S+P +EV WL+A+ FS V LG LTG QL + EL+
Sbjct: 608 PQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLNKEELK 667
Query: 539 MLCPQEAPRILSRLEAVRRML 559
+C +E R+ S+L + L
Sbjct: 668 KVCGEEGVRVYSQLTMQKAFL 688
>gi|148539853 epidermal growth factor receptor pathway substrate
8-like protein 1 isoform a [Homo sapiens]
Length = 723
Score = 242 bits (618), Expect = 6e-64
Identities = 180/551 (32%), Positives = 280/551 (50%), Gaps = 76/551 (13%)
Query: 3 RPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMT-CKQGSQRVQGPEDALQKLFEMDAQG 61
+PS+++IY RK YS + ++ + Q+ V HL+T C V EDA +KL MD+QG
Sbjct: 12 KPSAKSIYEQRKRYSTVVMADVS--QYPVNHLVTFCLGEDDGVHTVEDASRKLAVMDSQG 69
Query: 62 RVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPGL 121
RVW+Q+++L+V + LLD +KEEL+SY L +I + + S+L + QEP
Sbjct: 70 RVWAQEMLLRVSPDHVTLLDPASKEELESYPLGAIVRCDAVMPPGRSRSLLLLVCQEPER 129
Query: 122 PGTSTLLFQCQEVGAERLKTSLQKALEEELEQRP--RLGGLQPGQD---RWRGPAMERPL 176
FQ +GAE ++ +Q AL R R L+ Q+ R R PA E P
Sbjct: 130 AQPDVHFFQGLRLGAELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAETP- 188
Query: 177 PMEQARYLEPGIPPEQPHQRTLEHSLP---PSPRPLPRHTSAREPSAFTLPPPRRSSSPE 233
P+++ P + T+E P +P+P A+ P S+SP+
Sbjct: 189 PLQRR-------PSVRAVISTVERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPD 241
Query: 234 -----------DPERDEEVLNHVLRDIELFMGKLEKAQ--AKTSRKKKFGKKNK----DQ 276
ER+ ++LNHV D+E F+ +L+K+ A+ ++ G++++ +
Sbjct: 242 LGPRGPDLAVLQAEREVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGE 301
Query: 277 GGLT-------QAQYIDCFQKIKHSFNLLGRLATWLKETSAPELVHILFKSLNFILARCP 329
G LT +A+Y D QKIK++F+LL RL + + S+PEL+H LF L I+
Sbjct: 302 GLLTLRAKPPSEAEYTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSG 361
Query: 330 EAGLAAQVISPLLTPKAINLLQSCLSPPESNLWMGLGPAWTTSRADWTGDEPLPYQPTFS 389
A+ V P LT A+ LL+ ++P E+ LW LG +WT + + +E PY+P F
Sbjct: 362 GPEFASSVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFF 421
Query: 390 DDWQLP--EPSSQAPLGYQDPVS---------LRPSSPKPA-----------QPALKMQV 427
W+ P +P S+A ++DPV + S+P+ A +P L+ +
Sbjct: 422 SGWEPPVTDPQSRA---WEDPVEKQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESET 478
Query: 428 L-------YEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILEPLQPG 480
Y+F+ARN EL+V Q + LEVLD S++WW V++ AG+ GY+P NIL P PG
Sbjct: 479 AGKWVLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNILTP-YPG 537
Query: 481 TPGTQGQSPSR 491
QSP+R
Sbjct: 538 PRLHHSQSPAR 548
Score = 56.6 bits (135), Expect = 6e-08
Identities = 53/172 (30%), Positives = 78/172 (45%), Gaps = 31/172 (18%)
Query: 399 SQAPLGYQDPVSLRPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKR--- 455
SQ+P + P +P PA P + ++ PR + + L LD S++
Sbjct: 543 SQSPARSLNSTPPPPPAPAPAPPPALARPRWD----RPRWDSC---DSLNGLDPSEKEKF 595
Query: 456 -WWLVKNEA-------GRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSRPEEVTDW 507
L+ NE GRSG PS + PG + P P S EV W
Sbjct: 596 SQMLIVNEELQARLAQGRSG--PSRAV-------PGPRAPEPQLSP----GSDASEVRAW 642
Query: 508 LQAENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRML 559
LQA+ FS+ TV LG LTG+QL ++ EL+ + P+E R+ S++ R +L
Sbjct: 643 LQAKGFSSGTVDALGVLTGAQLFSLQKEELRAVSPEEGARVYSQVTVQRSLL 694
>gi|56682953 epidermal growth factor receptor pathway substrate 8
[Homo sapiens]
Length = 822
Score = 218 bits (555), Expect = 1e-56
Identities = 146/463 (31%), Positives = 229/463 (49%), Gaps = 64/463 (13%)
Query: 2 SRPSSRAIYLHRKEYSQN-LTSEPTLLQHRVEHLMT-CKQGSQRVQGPEDALQKLFEMDA 59
S+ S++A+Y RK Y+++ ++S + Q+RVEHL T + +D ++KL +DA
Sbjct: 37 SKTSAKALYEQRKNYARDSVSSVSDISQYRVEHLTTFVLDRKDAMITVDDGIRKLKLLDA 96
Query: 60 QGRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEP 119
+G+VW+QD+ILQV D + L+D+E+K EL+++ L++IQ +++CSY+S+L++ +EP
Sbjct: 97 KGKVWTQDMILQVDDRAVSLIDLESKNELENFPLNTIQHCQAVMHSCSYDSVLALVCKEP 156
Query: 120 GLPGTSTLLFQCQEVGAERLKTSLQKALEEELEQRPRLGGLQPGQDRWRGPAMERPLPME 179
LFQC EV A + ++ A+ + GG Q RP +
Sbjct: 157 TQNKPDLHLFQCDEVKANLISEDIESAISDSK------GGKQK----------RRPDALR 200
Query: 180 QARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHT-------------SAREPSAFTLPPP 226
+P IPP P +P P P T SA P
Sbjct: 201 MISNADPSIPPP-----------PRAPAPAPPGTVTQVDVRSRVAAWSAWAADQGDFEKP 249
Query: 227 RRSSSPEDP--------ERDEEVLNHVLRDIELFMGKLEKAQ------AKTSRKKKFGKK 272
R+ E+ +RD ++LNH+L DIE F+ KL+KA +K + KK +K
Sbjct: 250 RQYHEQEETPEMMAARIDRDVQILNHILDDIEFFITKLQKAAEAFSELSKRKKNKKGKRK 309
Query: 273 NKDQGGLTQA-------QYIDCFQKIKHSFNLLGRLATWLKETSAPELVHILFKSLNFIL 325
+G LT +++DCFQK KH FNLL +L + ++ SA +LVH LF LN ++
Sbjct: 310 GPGEGVLTLRAKPPPPDEFLDCFQKFKHGFNLLAKLKSHIQNPSAADLVHFLFTPLNMVV 369
Query: 326 ARCPEAGLAAQVISPLLTPKAINLLQSCLSPPESNLWMGLGPAWTTSRADWTGDEPL-PY 384
LA+ V+SPLL I+ L ++ E LWM LG W +RA+W ++ + PY
Sbjct: 370 QATGGPELASSVLSPLLNKDTIDFLNYTVNGDERQLWMSLGGTWMKARAEWPKEQFIPPY 429
Query: 385 QPTFSDDWQLPEPSSQAPLGYQDPVSLRPSSPKPAQPALKMQV 427
P F + W+ P + QD L S A+ K ++
Sbjct: 430 VPRFRNGWEPPMLNFMGATMEQDLYQLAESVANVAEHQRKQEI 472
Score = 65.5 bits (158), Expect = 1e-10
Identities = 31/78 (39%), Positives = 47/78 (60%)
Query: 412 RPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPS 471
R P QP + Y+F ARN EL+V++ + LE+LD K+WW V+N +G SG++P+
Sbjct: 523 RNYEPLKTQPKKYAKSKYDFVARNNSELSVLKDDILEILDDRKQWWKVRNASGDSGFVPN 582
Query: 472 NILEPLQPGTPGTQGQSP 489
NIL+ ++P G P
Sbjct: 583 NILDIVRPPESGLGRADP 600
Score = 55.5 bits (132), Expect = 1e-07
Identities = 58/220 (26%), Positives = 97/220 (44%), Gaps = 25/220 (11%)
Query: 348 NLLQSCLSPPESNLWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLPEPS-SQAPLGYQ 406
N + + PPES L P T + + + Y P +D P P + AP+
Sbjct: 582 NNILDIVRPPESGLGRADPPYTHTIQK-----QRMEYGPRPADTPPAPSPPPTPAPV--- 633
Query: 407 DPVSLRPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRS 466
PV L PS+P P P K+ A R+ + ++ S+R + + +S
Sbjct: 634 -PVPLPPSTPAPV-PVSKVP------ANITRQNSSSSDSGGSIVRDSQRHKQLPVDRRKS 685
Query: 467 GY--IPSNILEPLQPGTPGTQGQ---SPSRVPMLRLS--SRPEEVTDWLQAENFSTATVR 519
+ ++ L G Q + VP++ ++ S PE+V WLQ++ F+ TV
Sbjct: 686 QMEEVQDELIHRLTIGRSAAQKKFHVPRQNVPVINITYDSTPEDVKTWLQSKGFNPVTVN 745
Query: 520 TLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRML 559
+LG L G+QL + EL+ +CP E R+ S++ + L
Sbjct: 746 SLGVLNGAQLFSLNKDELRTVCP-EGARVYSQITVQKAAL 784
>gi|148539855 epidermal growth factor receptor pathway substrate
8-like protein 1 isoform b [Homo sapiens]
Length = 596
Score = 168 bits (426), Expect = 1e-41
Identities = 131/417 (31%), Positives = 205/417 (49%), Gaps = 73/417 (17%)
Query: 136 AERLKTSLQKALEEELEQRP--RLGGLQPGQD---RWRGPAMERPLPMEQARYLEPGIPP 190
AE ++ +Q AL R R L+ Q+ R R PA E P P+++ P
Sbjct: 17 AELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAETP-PLQRR-------PS 68
Query: 191 EQPHQRTLEHSLP---PSPRPLPRHTSAREPSAFTLPPPRRSSSPE-----------DPE 236
+ T+E P +P+P A+ P S+SP+ E
Sbjct: 69 VRAVISTVERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPDLGPRGPDLAVLQAE 128
Query: 237 RDEEVLNHVLRDIELFMGKLEKAQ--AKTSRKKKFGKKNK----DQGGLT-------QAQ 283
R+ ++LNHV D+E F+ +L+K+ A+ ++ G++++ +G LT +A+
Sbjct: 129 REVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLTLRAKPPSEAE 188
Query: 284 YIDCFQKIKHSFNLLGRLATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLT 343
Y D QKIK++F+LL RL + + S+PEL+H LF L I+ A+ V P LT
Sbjct: 189 YTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEFASSVRRPHLT 248
Query: 344 PKAINLLQSCLSPPESNLWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLP--EPSSQA 401
A+ LL+ ++P E+ LW LG +WT + + +E PY+P F W+ P +P S+A
Sbjct: 249 SDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFFSGWEPPVTDPQSRA 308
Query: 402 PLGYQDPVS---------LRPSSPKPA-----------QPALKMQVL-------YEFEAR 434
++DPV + S+P+ A +P L+ + Y+F+AR
Sbjct: 309 ---WEDPVEKQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESETAGKWVLCNYDFQAR 365
Query: 435 NPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSR 491
N EL+V Q + LEVLD S++WW V++ AG+ GY+P NIL P PG QSP+R
Sbjct: 366 NSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNILTP-YPGPRLHHSQSPAR 421
Score = 56.6 bits (135), Expect = 6e-08
Identities = 53/172 (30%), Positives = 78/172 (45%), Gaps = 31/172 (18%)
Query: 399 SQAPLGYQDPVSLRPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKR--- 455
SQ+P + P +P PA P + ++ PR + + L LD S++
Sbjct: 416 SQSPARSLNSTPPPPPAPAPAPPPALARPRWD----RPRWDSC---DSLNGLDPSEKEKF 468
Query: 456 -WWLVKNEA-------GRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSRPEEVTDW 507
L+ NE GRSG PS + PG + P P S EV W
Sbjct: 469 SQMLIVNEELQARLAQGRSG--PSRAV-------PGPRAPEPQLSP----GSDASEVRAW 515
Query: 508 LQAENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRML 559
LQA+ FS+ TV LG LTG+QL ++ EL+ + P+E R+ S++ R +L
Sbjct: 516 LQAKGFSSGTVDALGVLTGAQLFSLQKEELRAVSPEEGARVYSQVTVQRSLL 567
>gi|52630427 NCK adaptor protein 2 isoform B [Homo sapiens]
Length = 83
Score = 53.1 bits (126), Expect = 7e-07
Identities = 21/47 (44%), Positives = 34/47 (72%)
Query: 429 YEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILE 475
+++ A+ +EL + + E+L +LD SK WW V+N A R+GY+PSN +E
Sbjct: 11 WDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVE 57
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 53.1 bits (126), Expect = 7e-07
Identities = 21/47 (44%), Positives = 34/47 (72%)
Query: 429 YEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILE 475
+++ A+ +EL + + E+L +LD SK WW V+N A R+GY+PSN +E
Sbjct: 11 WDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVE 57
Score = 41.6 bits (96), Expect = 0.002
Identities = 20/59 (33%), Positives = 30/59 (50%), Gaps = 3/59 (5%)
Query: 425 MQVLYEFEARNPRELTVVQGEKLEVLD---HSKRWWLVKNEAGRSGYIPSNILEPLQPG 480
+Q LY F + EL +GE +EV++ + WW KN G+ G +P N + L G
Sbjct: 200 VQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDG 258
>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 53.1 bits (126), Expect = 7e-07
Identities = 21/47 (44%), Positives = 34/47 (72%)
Query: 429 YEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILE 475
+++ A+ +EL + + E+L +LD SK WW V+N A R+GY+PSN +E
Sbjct: 11 WDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVE 57
Score = 41.6 bits (96), Expect = 0.002
Identities = 20/59 (33%), Positives = 30/59 (50%), Gaps = 3/59 (5%)
Query: 425 MQVLYEFEARNPRELTVVQGEKLEVLD---HSKRWWLVKNEAGRSGYIPSNILEPLQPG 480
+Q LY F + EL +GE +EV++ + WW KN G+ G +P N + L G
Sbjct: 200 VQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDG 258
>gi|20149528 proline-serine-threonine phosphatase interacting
protein 1 [Homo sapiens]
Length = 416
Score = 51.6 bits (122), Expect = 2e-06
Identities = 27/82 (32%), Positives = 46/82 (56%), Gaps = 2/82 (2%)
Query: 397 PSSQAPLGYQDPVSLRPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEV-LDHSKR 455
P+ + G ++++ PA PA + + LY++ A+NP EL + G+ LEV L+
Sbjct: 336 PTPERNEGVYTAIAVQEIQGNPASPAQEYRALYDYTAQNPDELDLSAGDILEVILEGEDG 395
Query: 456 WWLVKNEAGRSGYIPSNILEPL 477
WW V+ G+ G++P + LE L
Sbjct: 396 WWTVERN-GQRGFVPGSYLEKL 416
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 50.8 bits (120), Expect = 3e-06
Identities = 22/48 (45%), Positives = 34/48 (70%), Gaps = 1/48 (2%)
Query: 428 LYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKN-EAGRSGYIPSNIL 474
LY++ A N R+L +++GEKL+VL + WWL ++ GR GY+PSN +
Sbjct: 66 LYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFV 113
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 48.9 bits (115), Expect = 1e-05
Identities = 18/47 (38%), Positives = 33/47 (70%)
Query: 429 YEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILE 475
+++ A+ +EL + + E+L +LD SK WW V+N ++G++PSN +E
Sbjct: 11 FDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVE 57
Score = 40.4 bits (93), Expect = 0.004
Identities = 21/69 (30%), Positives = 34/69 (49%), Gaps = 4/69 (5%)
Query: 425 MQVLYEFEARNPRELTVVQGEKLEVLD---HSKRWWLVKNEAGRSGYIPSNILEPLQPGT 481
+Q LY F + N EL +G+ ++V++ + WW + G G +P N + +Q
Sbjct: 195 VQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQ-NN 253
Query: 482 PGTQGQSPS 490
P T G PS
Sbjct: 254 PLTSGLEPS 262
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 46.2 bits (108), Expect = 8e-05
Identities = 25/80 (31%), Positives = 43/80 (53%), Gaps = 1/80 (1%)
Query: 394 LPEPSSQAPLGYQDPVSLRPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVLDHS 453
+P+P+S G S P + + + LY++EA + +L+ +G+++ VL+ S
Sbjct: 52 VPDPTSTIKPGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEES 111
Query: 454 KRWWLVKNEAGR-SGYIPSN 472
WW ++ A R GYIPSN
Sbjct: 112 GEWWKARSLATRKEGYIPSN 131
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 45.4 bits (106), Expect = 1e-04
Identities = 23/69 (33%), Positives = 43/69 (62%), Gaps = 6/69 (8%)
Query: 414 SSPKPAQP----ALKMQVLYEFEARNPRELTVVQGEKLEVLDHSK-RWWLVKN-EAGRSG 467
+SP+ A P LY++E+R +L+ +GE+L+++++++ WWL + G++G
Sbjct: 74 TSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTG 133
Query: 468 YIPSNILEP 476
YIPSN + P
Sbjct: 134 YIPSNYVAP 142
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 45.4 bits (106), Expect = 1e-04
Identities = 23/69 (33%), Positives = 43/69 (62%), Gaps = 6/69 (8%)
Query: 414 SSPKPAQP----ALKMQVLYEFEARNPRELTVVQGEKLEVLDHSK-RWWLVKN-EAGRSG 467
+SP+ A P LY++E+R +L+ +GE+L+++++++ WWL + G++G
Sbjct: 74 TSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTG 133
Query: 468 YIPSNILEP 476
YIPSN + P
Sbjct: 134 YIPSNYVAP 142
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 45.4 bits (106), Expect = 1e-04
Identities = 23/78 (29%), Positives = 42/78 (53%), Gaps = 7/78 (8%)
Query: 402 PLGYQDPVSLRPSSPKPAQPAL------KMQVLYEFEARNPRELTVVQGEKLEVLDHSKR 455
P +D + +P P+PA + K+ LY++ N +L + +G++ +L+ S
Sbjct: 190 PTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNL 249
Query: 456 -WWLVKNEAGRSGYIPSN 472
WW +++ G+ GYIPSN
Sbjct: 250 PWWRARDKNGQEGYIPSN 267
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 45.1 bits (105), Expect = 2e-04
Identities = 21/52 (40%), Positives = 33/52 (63%), Gaps = 6/52 (11%)
Query: 428 LYEFEARNPRELTVVQGEKLEVLDH-----SKRWWLVKNEAGRSGYIPSNIL 474
+Y F+ARNP EL+V +KL++L+ + WWL + G+ GY+PSN +
Sbjct: 1521 VYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVN-GKKGYVPSNYI 1571
Score = 34.3 bits (77), Expect = 0.31
Identities = 17/51 (33%), Positives = 25/51 (49%)
Query: 420 QPALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIP 470
+P LY F+A P EL G+K+ +L + WL + GR+G P
Sbjct: 243 EPGTYGVALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFP 293
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 44.7 bits (104), Expect = 2e-04
Identities = 21/52 (40%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 428 LYEFEARNPRELTVVQGEKLEVLDHSK-RWWLVKN-EAGRSGYIPSNILEPL 477
LY++EAR +L+ +GEK ++L+ S+ WW ++ G +GYIPSN + P+
Sbjct: 90 LYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV 141
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 44.7 bits (104), Expect = 2e-04
Identities = 21/52 (40%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 428 LYEFEARNPRELTVVQGEKLEVLDHSK-RWWLVKN-EAGRSGYIPSNILEPL 477
LY++EAR +L+ +GEK ++L+ S+ WW ++ G +GYIPSN + P+
Sbjct: 90 LYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV 141
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 44.7 bits (104), Expect = 2e-04
Identities = 21/52 (40%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 428 LYEFEARNPRELTVVQGEKLEVLDHSK-RWWLVKN-EAGRSGYIPSNILEPL 477
LY++EAR +L+ +GEK ++L+ S+ WW ++ G +GYIPSN + P+
Sbjct: 90 LYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV 141
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 44.7 bits (104), Expect = 2e-04
Identities = 19/51 (37%), Positives = 37/51 (72%), Gaps = 2/51 (3%)
Query: 428 LYEFEARNPRELTVVQGEKLEVLDHSK-RWWLVKNEA-GRSGYIPSNILEP 476
LY++EAR +L+ +GE+ +++++++ WW ++ A G++GYIPSN + P
Sbjct: 99 LYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAP 149
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 44.7 bits (104), Expect = 2e-04
Identities = 30/101 (29%), Positives = 50/101 (49%), Gaps = 7/101 (6%)
Query: 379 DEPLPYQPTFSDDWQLPEPSS--QAPLGYQDPVSLRPSSPKP----AQPALKMQVLYEFE 432
DE LP + T L + S+ Q+ G P +P P P A+ ++++ LY+F
Sbjct: 35 DEELPEKYTQRRRPWLSQLSNKKQSNTGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFL 94
Query: 433 ARNPRELTVVQGEKLEVLD-HSKRWWLVKNEAGRSGYIPSN 472
R P L + + E+ +L+ ++ WW ++ G G IPSN
Sbjct: 95 PREPCNLALRRAEEYLILEKYNPHWWKARDRLGNEGLIPSN 135
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 44.3 bits (103), Expect = 3e-04
Identities = 20/52 (38%), Positives = 36/52 (69%), Gaps = 2/52 (3%)
Query: 428 LYEFEARNPRELTVVQGEKLEVLDHSK-RWWLVKN-EAGRSGYIPSNILEPL 477
LY++EAR +LT +GEK +L++++ WW ++ +G++G IPSN + P+
Sbjct: 85 LYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV 136
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 44.3 bits (103), Expect = 3e-04
Identities = 20/52 (38%), Positives = 36/52 (69%), Gaps = 2/52 (3%)
Query: 428 LYEFEARNPRELTVVQGEKLEVLDHSK-RWWLVKN-EAGRSGYIPSNILEPL 477
LY++EAR +LT +GEK +L++++ WW ++ +G++G IPSN + P+
Sbjct: 85 LYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV 136
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 44.3 bits (103), Expect = 3e-04
Identities = 20/52 (38%), Positives = 36/52 (69%), Gaps = 2/52 (3%)
Query: 428 LYEFEARNPRELTVVQGEKLEVLDHSK-RWWLVKN-EAGRSGYIPSNILEPL 477
LY++EAR +LT +GEK +L++++ WW ++ +G++G IPSN + P+
Sbjct: 85 LYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV 136
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 43.9 bits (102), Expect = 4e-04
Identities = 36/153 (23%), Positives = 69/153 (45%), Gaps = 12/153 (7%)
Query: 383 PYQPTFSDDWQLPEP--SSQAPLGYQDPVSLRPSSPKPAQPALKMQVLYEFEARNPRELT 440
P P+ + D + P S+ +G P R + K PA + +Y+F+A+ +EL+
Sbjct: 219 PSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA---KAVYDFKAQTSKELS 275
Query: 441 VVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSR 500
+G+ + +L + W GR G P + +E L P + P+R P ++
Sbjct: 276 FKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP----PEKAQPARPPP---PAQ 328
Query: 501 PEEVTDWLQAENFSTATVRTLGSLTGSQLLRIR 533
P E+ + + NF+ T L G +++ ++
Sbjct: 329 PGEIGEAIAKYNFNADTNVELSLRKGDRVILLK 361
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 43.9 bits (102), Expect = 4e-04
Identities = 36/153 (23%), Positives = 69/153 (45%), Gaps = 12/153 (7%)
Query: 383 PYQPTFSDDWQLPEP--SSQAPLGYQDPVSLRPSSPKPAQPALKMQVLYEFEARNPRELT 440
P P+ + D + P S+ +G P R + K PA + +Y+F+A+ +EL+
Sbjct: 551 PSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA---KAVYDFKAQTSKELS 607
Query: 441 VVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSR 500
+G+ + +L + W GR G P + +E L P + P+R P ++
Sbjct: 608 FKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP----PEKAQPARPPP---PAQ 660
Query: 501 PEEVTDWLQAENFSTATVRTLGSLTGSQLLRIR 533
P E+ + + NF+ T L G +++ ++
Sbjct: 661 PGEIGEAIAKYNFNADTNVELSLRKGDRVILLK 693
Score = 29.6 bits (65), Expect = 7.7
Identities = 30/110 (27%), Positives = 43/110 (39%), Gaps = 9/110 (8%)
Query: 173 ERPLPMEQARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPS--AFTLPPPRRSS 230
ERP P+ P P +P + + SP P PR + A PS A L P R
Sbjct: 405 ERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPR-SGAPTPSSRAPALSPTRPPK 463
Query: 231 SPEDPERDEEVLNHVLRDIELFMG----KLEKAQAKTSRKKKFGKKNKDQ 276
P D +D + V + L+ LE+ + S F K+ K +
Sbjct: 464 KPLDYVQDHS--SGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSE 511
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 43.9 bits (102), Expect = 4e-04
Identities = 36/153 (23%), Positives = 69/153 (45%), Gaps = 12/153 (7%)
Query: 383 PYQPTFSDDWQLPEP--SSQAPLGYQDPVSLRPSSPKPAQPALKMQVLYEFEARNPRELT 440
P P+ + D + P S+ +G P R + K PA + +Y+F+A+ +EL+
Sbjct: 388 PSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA---KAVYDFKAQTSKELS 444
Query: 441 VVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSR 500
+G+ + +L + W GR G P + +E L P + P+R P ++
Sbjct: 445 FKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP----PEKAQPARPPP---PAQ 497
Query: 501 PEEVTDWLQAENFSTATVRTLGSLTGSQLLRIR 533
P E+ + + NF+ T L G +++ ++
Sbjct: 498 PGEIGEAIAKYNFNADTNVELSLRKGDRVILLK 530
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 43.9 bits (102), Expect = 4e-04
Identities = 36/153 (23%), Positives = 69/153 (45%), Gaps = 12/153 (7%)
Query: 383 PYQPTFSDDWQLPEP--SSQAPLGYQDPVSLRPSSPKPAQPALKMQVLYEFEARNPRELT 440
P P+ + D + P S+ +G P R + K PA + +Y+F+A+ +EL+
Sbjct: 458 PSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA---KAVYDFKAQTSKELS 514
Query: 441 VVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSR 500
+G+ + +L + W GR G P + +E L P + P+R P ++
Sbjct: 515 FKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP----PEKAQPARPPP---PAQ 567
Query: 501 PEEVTDWLQAENFSTATVRTLGSLTGSQLLRIR 533
P E+ + + NF+ T L G +++ ++
Sbjct: 568 PGEIGEAIAKYNFNADTNVELSLRKGDRVILLK 600
Score = 29.6 bits (65), Expect = 7.7
Identities = 30/110 (27%), Positives = 43/110 (39%), Gaps = 9/110 (8%)
Query: 173 ERPLPMEQARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPS--AFTLPPPRRSS 230
ERP P+ P P +P + + SP P PR + A PS A L P R
Sbjct: 312 ERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPR-SGAPTPSSRAPALSPTRPPK 370
Query: 231 SPEDPERDEEVLNHVLRDIELFMG----KLEKAQAKTSRKKKFGKKNKDQ 276
P D +D + V + L+ LE+ + S F K+ K +
Sbjct: 371 KPLDYVQDHS--SGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSE 418
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,940,156
Number of Sequences: 37866
Number of extensions: 1473001
Number of successful extensions: 9455
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 104
Number of HSP's successfully gapped in prelim test: 336
Number of HSP's that attempted gapping in prelim test: 8439
Number of HSP's gapped (non-prelim): 1267
length of query: 563
length of database: 18,247,518
effective HSP length: 107
effective length of query: 456
effective length of database: 14,195,856
effective search space: 6473310336
effective search space used: 6473310336
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.