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Search of human proteins with 20986523
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20986523 mitogen-activated protein kinase 8 isoform JNK1
alpha2 [Homo sapiens]
(427 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alph... 866 0.0
gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta... 849 0.0
gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo ... 790 0.0
gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo ... 790 0.0
gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha... 773 0.0
gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta... 756 0.0
gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo s... 723 0.0
gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta... 717 0.0
gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alph... 702 0.0
gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta... 665 0.0
gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alph... 651 0.0
gi|20986508 mitogen-activated protein kinase 10 isoform 4 [Homo ... 525 e-149
gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gam... 408 e-114
gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens] 332 5e-91
gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens] 321 7e-88
gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ... 316 3e-86
gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo s... 308 5e-84
gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens] 307 1e-83
gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo ... 273 2e-73
gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo ... 269 4e-72
gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens] 259 3e-69
gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens] 259 3e-69
gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s... 257 2e-68
gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s... 253 3e-67
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s... 249 3e-66
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ... 249 3e-66
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ... 249 3e-66
gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo ... 207 2e-53
gi|149408126 nemo like kinase [Homo sapiens] 204 9e-53
gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens] 196 3e-50
>gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alpha2
[Homo sapiens]
Length = 427
Score = 866 bits (2238), Expect = 0.0
Identities = 427/427 (100%), Positives = 427/427 (100%)
Query: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
Sbjct: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
Query: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240
Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
Query: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA
Sbjct: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420
Query: 421 GPLGCCR 427
GPLGCCR
Sbjct: 421 GPLGCCR 427
>gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta2
[Homo sapiens]
Length = 427
Score = 849 bits (2194), Expect = 0.0
Identities = 419/427 (98%), Positives = 423/427 (99%)
Query: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
Sbjct: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
Query: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240
MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIMGEM+ +LFPG D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240
Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
Query: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA
Sbjct: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420
Query: 421 GPLGCCR 427
GPLGCCR
Sbjct: 421 GPLGCCR 427
>gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo
sapiens]
Length = 464
Score = 790 bits (2041), Expect = 0.0
Identities = 388/427 (90%), Positives = 407/427 (95%), Gaps = 1/427 (0%)
Query: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
MS+SK DN FYSVE+GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA+L+RNVAIKKLSRP
Sbjct: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98
Query: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
FQNQTHAKRAYRELVLMKCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVIQ
Sbjct: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158
Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
Sbjct: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218
Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240
MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIMGEMV HKILFPGRDYIDQWNKVIEQ
Sbjct: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278
Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
LGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHNKLKASQARDLLSK
Sbjct: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338
Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
MLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREHTIEEWKELIYKEV
Sbjct: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398
Query: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420
M+ EE+TKNGV++GQPSP GAAV N S+ SSSVND+SSMSTD TLASDTDSSLEA+A
Sbjct: 399 MNSEEKTKNGVVKGQPSPSGAAV-NSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASA 457
Query: 421 GPLGCCR 427
GPLGCCR
Sbjct: 458 GPLGCCR 464
>gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo
sapiens]
Length = 426
Score = 790 bits (2041), Expect = 0.0
Identities = 388/427 (90%), Positives = 407/427 (95%), Gaps = 1/427 (0%)
Query: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
MS+SK DN FYSVE+GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA+L+RNVAIKKLSRP
Sbjct: 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 60
Query: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
FQNQTHAKRAYRELVLMKCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVIQ
Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 120
Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240
MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIMGEMV HKILFPGRDYIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 240
Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
LGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHNKLKASQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 300
Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
MLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREHTIEEWKELIYKEV
Sbjct: 301 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 360
Query: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420
M+ EE+TKNGV++GQPSP GAAV N S+ SSSVND+SSMSTD TLASDTDSSLEA+A
Sbjct: 361 MNSEEKTKNGVVKGQPSPSGAAV-NSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASA 419
Query: 421 GPLGCCR 427
GPLGCCR
Sbjct: 420 GPLGCCR 426
>gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha1
[Homo sapiens]
Length = 384
Score = 773 bits (1996), Expect = 0.0
Identities = 379/379 (100%), Positives = 379/379 (100%)
Query: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
Sbjct: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
Query: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240
Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
Query: 361 MDLEERTKNGVIRGQPSPL 379
MDLEERTKNGVIRGQPSPL
Sbjct: 361 MDLEERTKNGVIRGQPSPL 379
>gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta1
[Homo sapiens]
Length = 384
Score = 756 bits (1952), Expect = 0.0
Identities = 371/379 (97%), Positives = 375/379 (98%)
Query: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
Sbjct: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
Query: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240
MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIMGEM+ +LFPG D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240
Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
Query: 361 MDLEERTKNGVIRGQPSPL 379
MDLEERTKNGVIRGQPSPL
Sbjct: 361 MDLEERTKNGVIRGQPSPL 379
>gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo
sapiens]
Length = 422
Score = 723 bits (1867), Expect = 0.0
Identities = 350/378 (92%), Positives = 366/378 (96%)
Query: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
MS+SK DN FYSVE+GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA+L+RNVAIKKLSRP
Sbjct: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98
Query: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
FQNQTHAKRAYRELVLMKCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVIQ
Sbjct: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158
Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
Sbjct: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218
Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240
MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIMGEMV HKILFPGRDYIDQWNKVIEQ
Sbjct: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278
Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
LGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHNKLKASQARDLLSK
Sbjct: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338
Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
MLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREHTIEEWKELIYKEV
Sbjct: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398
Query: 361 MDLEERTKNGVIRGQPSP 378
M+ EE+TKNGV++GQPSP
Sbjct: 399 MNSEEKTKNGVVKGQPSP 416
>gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta2
[Homo sapiens]
Length = 424
Score = 717 bits (1851), Expect = 0.0
Identities = 351/427 (82%), Positives = 384/427 (89%), Gaps = 3/427 (0%)
Query: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L NVA+KKLSRP
Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
Query: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI
Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240
MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIM EMV HK+LFPGRDYIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240
Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
LGTP EFMKKLQPTVR YVENRPKY G FE+LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
MLVID KRISVDEAL+HPYI VWYDP+EAEAPPP+I D QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
Query: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420
MD EER+KNGV++ QPS A ++ + PS SSS+ND+SSMST+ TLASDTDSSL+A+
Sbjct: 361 MDWEERSKNGVVKDQPSD---AAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDAST 417
Query: 421 GPLGCCR 427
GPL CR
Sbjct: 418 GPLEGCR 424
>gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alpha2
[Homo sapiens]
Length = 424
Score = 702 bits (1813), Expect = 0.0
Identities = 345/427 (80%), Positives = 381/427 (89%), Gaps = 3/427 (0%)
Query: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L NVA+KKLSRP
Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
Query: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI
Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240
MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIMGE+V ++F G D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240
Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
LGTP EFMKKLQPTVR YVENRPKY G FE+LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
MLVID KRISVDEAL+HPYI VWYDP+EAEAPPP+I D QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
Query: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420
MD EER+KNGV++ QPS A ++ + PS SSS+ND+SSMST+ TLASDTDSSL+A+
Sbjct: 361 MDWEERSKNGVVKDQPSD---AAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDAST 417
Query: 421 GPLGCCR 427
GPL CR
Sbjct: 418 GPLEGCR 424
>gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta1
[Homo sapiens]
Length = 382
Score = 665 bits (1717), Expect = 0.0
Identities = 322/377 (85%), Positives = 347/377 (92%)
Query: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L NVA+KKLSRP
Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
Query: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI
Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240
MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIM EMV HK+LFPGRDYIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240
Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
LGTP EFMKKLQPTVR YVENRPKY G FE+LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
MLVID KRISVDEAL+HPYI VWYDP+EAEAPPP+I D QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
Query: 361 MDLEERTKNGVIRGQPS 377
MD EER+KNGV++ QPS
Sbjct: 361 MDWEERSKNGVVKDQPS 377
>gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alpha1
[Homo sapiens]
Length = 382
Score = 651 bits (1679), Expect = 0.0
Identities = 316/377 (83%), Positives = 344/377 (91%)
Query: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L NVA+KKLSRP
Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
Query: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI
Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240
MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIMGE+V ++F G D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240
Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
LGTP EFMKKLQPTVR YVENRPKY G FE+LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
MLVID KRISVDEAL+HPYI VWYDP+EAEAPPP+I D QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
Query: 361 MDLEERTKNGVIRGQPS 377
MD EER+KNGV++ QPS
Sbjct: 361 MDWEERSKNGVVKDQPS 377
>gi|20986508 mitogen-activated protein kinase 10 isoform 4 [Homo
sapiens]
Length = 277
Score = 525 bits (1353), Expect = e-149
Identities = 252/271 (92%), Positives = 262/271 (96%)
Query: 108 MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 167
MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI
Sbjct: 1 MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60
Query: 168 LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPG 227
LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIMGEMV HKILFPG
Sbjct: 61 LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 120
Query: 228 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHN 287
RDYIDQWNKVIEQLGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHN
Sbjct: 121 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 180
Query: 288 KLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREH 347
KLKASQARDLLSKMLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREH
Sbjct: 181 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 240
Query: 348 TIEEWKELIYKEVMDLEERTKNGVIRGQPSP 378
TIEEWKELIYKEVM+ EE+TKNGV++GQPSP
Sbjct: 241 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSP 271
>gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gamma
[Homo sapiens]
Length = 242
Score = 408 bits (1049), Expect = e-114
Identities = 200/231 (86%), Positives = 214/231 (92%)
Query: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L NVA+KKLSRP
Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
Query: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI
Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYI 231
MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIMGE+V ++F G D I
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDRI 231
>gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
Length = 364
Score = 332 bits (850), Expect = 5e-91
Identities = 175/359 (48%), Positives = 242/359 (67%), Gaps = 21/359 (5%)
Query: 10 FYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKR 69
FY E+ + + V +R Q L+P+GSGA G VC+AYDA L + VA+KKLSRPFQ+ HA+R
Sbjct: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67
Query: 70 AYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERM 128
YREL L+K + H+N+IGLL+VFTP S+E+F +VY+V LM A+L +++ + L E +
Sbjct: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127
Query: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 188
+L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A MT YV T
Sbjct: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVAT 185
Query: 189 RYYRAPEVILG-MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPE 247
R+YRAPE++L M Y + VD+WSVGCIM E++ K LFPG DYIDQ +++E +GTP PE
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245
Query: 248 FMKKLQPT-VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDA 306
+ K+ RTY+++ P +F N L A DLL +MLV+D+
Sbjct: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGA--------NPL----AIDLLGRMLVLDS 293
Query: 307 SKRISVDEALQHPYINVWYDP-SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLE 364
+R+S EAL H Y + ++DP E EA P D+ ++ +E T+EEWKEL Y+EV+ +
Sbjct: 294 DQRVSAAEALAHAYFSQYHDPEDEPEAEP---YDESVEAKERTLEEWKELTYQEVLSFK 349
>gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]
Length = 365
Score = 321 bits (823), Expect = 7e-88
Identities = 169/360 (46%), Positives = 233/360 (64%), Gaps = 19/360 (5%)
Query: 6 RDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQT 65
R FY ++ + + + K Y + +GSGA G VC+A D VAIKKLSRPFQ++
Sbjct: 5 RKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI 64
Query: 66 HAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDH 125
AKRAYREL+L+K + H+N+IGLL+VFTP SL F D Y+VM M +L +++ ME
Sbjct: 65 FAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSE 124
Query: 126 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPY 185
E++ YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A MT Y
Sbjct: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGY 182
Query: 186 VVTRYYRAPEVILG-MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTP 244
VVTR+YRAPEVIL M Y + VD+WSVGCIM EM+ K LF G+DY+DQ ++++ G P
Sbjct: 183 VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP 242
Query: 245 CPEFMKKL-QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLV 303
EF++KL ++Y+++ P+ F +LFP + QA DLL KML
Sbjct: 243 GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA------------SPQAADLLEKMLE 290
Query: 304 IDASKRISVDEALQHPYINVWYDP-SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMD 362
+D KR++ +AL HP+ + DP E EA P D L+ + T++EWK+ IYKE+++
Sbjct: 291 LDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPF--DDSLEHEKLTVDEWKQHIYKEIVN 348
>gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo
sapiens]
Length = 360
Score = 316 bits (809), Expect = 3e-86
Identities = 171/361 (47%), Positives = 234/361 (64%), Gaps = 19/361 (5%)
Query: 4 SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 63
S+ FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+
Sbjct: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61
Query: 64 QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-ME 122
HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V LM A+L +++ +
Sbjct: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121
Query: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182
L + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T M
Sbjct: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179
Query: 183 TPYVVTRYYRAPEVILG-MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQL 241
T YV TR+YRAPE++L M Y + VD+WSVGCIM E++ + LFPG D+IDQ ++ +
Sbjct: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239
Query: 242 GTPCPEFMKKL-QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
GTP E +KK+ + R Y+++ + +F +F N L A DLL K
Sbjct: 240 GTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGA--------NPL----AVDLLEK 287
Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
MLV+D+ KRI+ +AL H Y ++DP + P D+ + R+ I+EWK L Y EV
Sbjct: 288 MLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPY--DQSFESRDLLIDEWKSLTYDEV 345
Query: 361 M 361
+
Sbjct: 346 I 346
>gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo
sapiens]
Length = 360
Score = 308 bits (790), Expect = 5e-84
Identities = 169/362 (46%), Positives = 233/362 (64%), Gaps = 21/362 (5%)
Query: 4 SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 63
S+ FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+
Sbjct: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61
Query: 64 QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-ME 122
HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V LM A+L +++ +
Sbjct: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121
Query: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182
L + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T M
Sbjct: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179
Query: 183 TPYVVTRYYRAPEVILG-MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQL 241
T YV TR+YRAPE++L M Y + VD+WSVGCIM E++ + LFPG D+I+Q +++
Sbjct: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLT 239
Query: 242 GTPCPEFMKKLQPT--VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLS 299
GTP P ++ P+ R Y+++ + +F +F N L A DLL
Sbjct: 240 GTP-PAYLINRMPSHEARNYIQSLTQMPKMNFANVFIGA--------NPL----AVDLLE 286
Query: 300 KMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359
KMLV+D+ KRI+ +AL H Y ++DP + P D+ + R+ I+EWK L Y E
Sbjct: 287 KMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPY--DQSFESRDLLIDEWKSLTYDE 344
Query: 360 VM 361
V+
Sbjct: 345 VI 346
>gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]
Length = 367
Score = 307 bits (787), Expect = 1e-83
Identities = 165/375 (44%), Positives = 240/375 (64%), Gaps = 19/375 (5%)
Query: 8 NNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHA 67
+ FY E+ + + V Y++L+P+GSGA G VC+A D VAIKKL RPFQ++ A
Sbjct: 9 SGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA 68
Query: 68 KRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHE 126
KRAYREL L+K + H+N+IGLL+VFTP ++L++F D Y+VM M +L ++++ E L +
Sbjct: 69 KRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED 128
Query: 127 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYV 186
R+ +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT YV
Sbjct: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYV 186
Query: 187 VTRYYRAPEVILG-MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPC 245
VTR+YRAPEVIL M Y + VD+WSVGCIM EM+ K LF G D++DQ ++++ GTP
Sbjct: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246
Query: 246 PEFMKKLQ-PTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVI 304
EF+++LQ + Y++ P+ F + + + A +LL KMLV+
Sbjct: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTNA------------SPLAVNLLEKMLVL 294
Query: 305 DASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLE 364
DA +R++ EAL HPY +D + P + D D+ + T++EWK + YKEV+ +
Sbjct: 295 DAEQRVTAGEALAHPYFESLHDTE--DEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFK 352
Query: 365 ERTKNGVIRGQPSPL 379
+ G + +PL
Sbjct: 353 PPRQLGARVSKETPL 367
>gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo
sapiens]
Length = 297
Score = 273 bits (699), Expect = 2e-73
Identities = 140/275 (50%), Positives = 191/275 (69%), Gaps = 5/275 (1%)
Query: 4 SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 63
S+ FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+
Sbjct: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61
Query: 64 QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-ME 122
HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V LM A+L +++ +
Sbjct: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121
Query: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182
L + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T M
Sbjct: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179
Query: 183 TPYVVTRYYRAPEVILG-MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQL 241
T YV TR+YRAPE++L M Y + VD+WSVGCIM E++ + LFPG D+IDQ ++ +
Sbjct: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239
Query: 242 GTPCPEFMKKL-QPTVRTYVENRPKYAGYSFEKLF 275
GTP E +KK+ + R Y+++ + +F +F
Sbjct: 240 GTPGAELLKKISSESARNYIQSLTQMPKMNFANVF 274
>gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo
sapiens]
Length = 307
Score = 269 bits (687), Expect = 4e-72
Identities = 136/251 (54%), Positives = 180/251 (71%), Gaps = 4/251 (1%)
Query: 4 SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 63
S+ FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+
Sbjct: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61
Query: 64 QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-ME 122
HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V LM A+L +++ +
Sbjct: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121
Query: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182
L + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T M
Sbjct: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179
Query: 183 TPYVVTRYYRAPEVILG-MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQL 241
T YV TR+YRAPE++L M Y + VD+WSVGCIM E++ + LFPG D+IDQ ++ +
Sbjct: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239
Query: 242 GTPCPEFMKKL 252
GTP E +KK+
Sbjct: 240 GTPGAELLKKI 250
>gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 259 bits (662), Expect = 3e-69
Identities = 147/348 (42%), Positives = 224/348 (64%), Gaps = 24/348 (6%)
Query: 20 FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79
F V RY NL IG GA G+VC+AYD + + VAIKK+S PF++QT+ +R RE+ ++
Sbjct: 19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLR 77
Query: 80 VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLCG 138
H+NIIG+ ++ ++E+ +DVYIV +LM+ +L ++++ + L ++ + Y LYQ+L G
Sbjct: 78 FRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRG 136
Query: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 194
+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP
Sbjct: 137 LKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAP 196
Query: 195 EVIL-GMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMK-KL 252
E++L GY +++D+WSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E + +
Sbjct: 197 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 256
Query: 253 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 312
R Y+ + P + +LFP+ AD S+A DLL KML + KRI V
Sbjct: 257 NLKARNYLLSLPHKNKVPWNRLFPN----AD--------SKALDLLDKMLTFNPHKRIEV 304
Query: 313 DEALQHPYINVWYDPS-EAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359
++AL HPY+ +YDPS E A P D +LD+ E+ KELI++E
Sbjct: 305 EQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350
>gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 259 bits (662), Expect = 3e-69
Identities = 147/348 (42%), Positives = 224/348 (64%), Gaps = 24/348 (6%)
Query: 20 FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79
F V RY NL IG GA G+VC+AYD + + VAIKK+S PF++QT+ +R RE+ ++
Sbjct: 19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLR 77
Query: 80 VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLCG 138
H+NIIG+ ++ ++E+ +DVYIV +LM+ +L ++++ + L ++ + Y LYQ+L G
Sbjct: 78 FRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRG 136
Query: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 194
+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP
Sbjct: 137 LKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAP 196
Query: 195 EVIL-GMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMK-KL 252
E++L GY +++D+WSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E + +
Sbjct: 197 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 256
Query: 253 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 312
R Y+ + P + +LFP+ AD S+A DLL KML + KRI V
Sbjct: 257 NLKARNYLLSLPHKNKVPWNRLFPN----AD--------SKALDLLDKMLTFNPHKRIEV 304
Query: 313 DEALQHPYINVWYDPS-EAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359
++AL HPY+ +YDPS E A P D +LD+ E+ KELI++E
Sbjct: 305 EQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350
>gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo
sapiens]
Length = 379
Score = 257 bits (656), Expect = 2e-68
Identities = 142/348 (40%), Positives = 221/348 (63%), Gaps = 24/348 (6%)
Query: 20 FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79
F V RY L+ IG GA G+V +AYD + + VAIKK+S PF++QT+ +R RE+ ++
Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94
Query: 80 VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 138
H+N+IG+ ++ +LE +DVYIV +LM+ +L ++++ +L ++ + Y LYQ+L G
Sbjct: 95 FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
Query: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 194
+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP
Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
Query: 195 EVIL-GMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMK-KL 252
E++L GY +++D+WSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E + +
Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273
Query: 253 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 312
R Y+++ P ++ KLFP S+A DLL +ML + +KRI+V
Sbjct: 274 NMKARNYLQSLPSKTKVAWAKLFPK------------SDSKALDLLDRMLTFNPNKRITV 321
Query: 313 DEALQHPYINVWYDPS-EAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359
+EAL HPY+ +YDP+ E A P +LD+ E KELI++E
Sbjct: 322 EEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 367
>gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo
sapiens]
Length = 357
Score = 253 bits (645), Expect = 3e-67
Identities = 132/323 (40%), Positives = 208/323 (64%), Gaps = 21/323 (6%)
Query: 20 FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79
F V RY L+ IG GA G+V +AYD + + VAIKK+S PF++QT+ +R RE+ ++
Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94
Query: 80 VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 138
H+N+IG+ ++ +LE +DVYIV +LM+ +L ++++ +L ++ + Y LYQ+L G
Sbjct: 95 FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
Query: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 194
+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP
Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
Query: 195 EVIL-GMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMK-KL 252
E++L GY +++D+WSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E + +
Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273
Query: 253 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 312
R Y+++ P ++ KLFP S+A DLL +ML + +KRI+V
Sbjct: 274 NMKARNYLQSLPSKTKVAWAKLFPK------------SDSKALDLLDRMLTFNPNKRITV 321
Query: 313 DEALQHPYINVWYDPSEAEAPPP 335
+EAL HPY+ +YDP++ P
Sbjct: 322 EEALAHPYLEQYYDPTDEVGQSP 344
>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 249 bits (637), Expect = 3e-66
Identities = 152/374 (40%), Positives = 219/374 (58%), Gaps = 28/374 (7%)
Query: 17 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVL 76
D TF V Y+ ++ IG+GA G+V +A + + VAIKK+ F T+AKR REL +
Sbjct: 46 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105
Query: 77 MKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVI--QMELDHERMSYLLYQ 134
+K H NII + ++ P EF+ VY+V++LM+++L Q+I L E + Y LYQ
Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165
Query: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS-----FMMTPYVVTR 189
+L G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR TS + MT YV TR
Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225
Query: 190 YYRAPEVILGM-GYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEF 248
+YRAPE++L + Y + +DLWSVGCI GEM+ + LFPG++Y+ Q ++ LGTP P
Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285
Query: 249 MKKL-QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDAS 307
++ + VR Y+++ P +E ++P AD QA LL +ML + S
Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPG----AD--------RQALSLLGRMLRFEPS 333
Query: 308 KRISVDEALQHPYINVWYDP-SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEER 366
RIS AL+HP++ ++DP E + PP D D T E KE I E+ D R
Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPPF--DFAFDREALTRERIKEAIVAEIEDFHAR 391
Query: 367 TKNGV---IRGQPS 377
+ G+ IR QPS
Sbjct: 392 -REGIRQQIRFQPS 404
>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 249 bits (637), Expect = 3e-66
Identities = 152/374 (40%), Positives = 219/374 (58%), Gaps = 28/374 (7%)
Query: 17 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVL 76
D TF V Y+ ++ IG+GA G+V +A + + VAIKK+ F T+AKR REL +
Sbjct: 46 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105
Query: 77 MKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVI--QMELDHERMSYLLYQ 134
+K H NII + ++ P EF+ VY+V++LM+++L Q+I L E + Y LYQ
Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165
Query: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS-----FMMTPYVVTR 189
+L G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR TS + MT YV TR
Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225
Query: 190 YYRAPEVILGM-GYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEF 248
+YRAPE++L + Y + +DLWSVGCI GEM+ + LFPG++Y+ Q ++ LGTP P
Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285
Query: 249 MKKL-QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDAS 307
++ + VR Y+++ P +E ++P AD QA LL +ML + S
Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPG----AD--------RQALSLLGRMLRFEPS 333
Query: 308 KRISVDEALQHPYINVWYDP-SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEER 366
RIS AL+HP++ ++DP E + PP D D T E KE I E+ D R
Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPPF--DFAFDREALTRERIKEAIVAEIEDFHAR 391
Query: 367 TKNGV---IRGQPS 377
+ G+ IR QPS
Sbjct: 392 -REGIRQQIRFQPS 404
>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 249 bits (637), Expect = 3e-66
Identities = 152/374 (40%), Positives = 219/374 (58%), Gaps = 28/374 (7%)
Query: 17 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVL 76
D TF V Y+ ++ IG+GA G+V +A + + VAIKK+ F T+AKR REL +
Sbjct: 46 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105
Query: 77 MKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVI--QMELDHERMSYLLYQ 134
+K H NII + ++ P EF+ VY+V++LM+++L Q+I L E + Y LYQ
Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165
Query: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS-----FMMTPYVVTR 189
+L G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR TS + MT YV TR
Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225
Query: 190 YYRAPEVILGM-GYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEF 248
+YRAPE++L + Y + +DLWSVGCI GEM+ + LFPG++Y+ Q ++ LGTP P
Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285
Query: 249 MKKL-QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDAS 307
++ + VR Y+++ P +E ++P AD QA LL +ML + S
Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPG----AD--------RQALSLLGRMLRFEPS 333
Query: 308 KRISVDEALQHPYINVWYDP-SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEER 366
RIS AL+HP++ ++DP E + PP D D T E KE I E+ D R
Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPPF--DFAFDREALTRERIKEAIVAEIEDFHAR 391
Query: 367 TKNGV---IRGQPS 377
+ G+ IR QPS
Sbjct: 392 -REGIRQQIRFQPS 404
>gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo
sapiens]
Length = 335
Score = 207 bits (526), Expect = 2e-53
Identities = 126/347 (36%), Positives = 191/347 (55%), Gaps = 66/347 (19%)
Query: 20 FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79
F V RY L+ IG GA G+V +AYD + + VAIKK+S PF++QT+ +R RE+ ++
Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94
Query: 80 VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 138
H+N+IG+ ++ +LE +DVYIV +LM+ +L ++++ +L ++ + Y LYQ+L G
Sbjct: 95 FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
Query: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 194
+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP
Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
Query: 195 EVIL-GMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ 253
E++L GY +++D+WSVGCI+ EM+ ++ +FPG+ Y+DQ N + L + M
Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI---LALDLLDRMLTFN 270
Query: 254 PTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVD 313
P R VE
Sbjct: 271 PNKRITVE---------------------------------------------------- 278
Query: 314 EALQHPYINVWYDPS-EAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359
EAL HPY+ +YDP+ E A P +LD+ E KELI++E
Sbjct: 279 EALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 323
>gi|149408126 nemo like kinase [Homo sapiens]
Length = 527
Score = 204 bits (520), Expect = 9e-53
Identities = 117/298 (39%), Positives = 177/298 (59%), Gaps = 16/298 (5%)
Query: 30 KPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLL 89
+PIG GA G+V + D + VA+KK+ FQN KR +REL ++ H N++ L
Sbjct: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201
Query: 90 NVFTPQKSLEEFQDVYIVMELMDANLCQVI--QMELDHERMSYLLYQMLCGIKHLHSAGI 147
++ P ++ F+++Y+V ELM ++L ++I L + + LYQ+L G+K+LHSAGI
Sbjct: 202 DILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260
Query: 148 IHRDLKPSNIVVKSDCTLKILDFGLART--AGTSFMMTPYVVTRYYRAPEVILGMGYKEN 205
+HRD+KP N++V S+C LKI DFGLAR S MT VVT+YYRAPE+++G + N
Sbjct: 261 LHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSN 320
Query: 206 -VDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRP 264
+D+WSVGCI E++ +ILF + I Q + + + LGTP E M+ + ++ P
Sbjct: 321 AIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGP 380
Query: 265 KYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYIN 322
++ VL+ S+ +A LL +MLV D SKRIS +AL HPY++
Sbjct: 381 ------HKQPSLPVLYTLSSQ----ATHEAVHLLCRMLVFDPSKRISAKDALAHPYLD 428
>gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]
Length = 544
Score = 196 bits (498), Expect = 3e-50
Identities = 121/355 (34%), Positives = 199/355 (56%), Gaps = 32/355 (9%)
Query: 22 VLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCV- 80
+++RY + +G GA GIV A D VAIKK+ F+++T A+R +RE+ L++
Sbjct: 9 IVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG 68
Query: 81 NHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME--LDHERMSYLLYQMLCG 138
+H NII LL+V + +D+Y+V E MD +L VI+ L + + YQ+L
Sbjct: 69 DHPNIISLLDVIRAEND----RDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRA 124
Query: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG------TSFMMTPYVVTRYYR 192
+ LHS ++HRD KPSN+++ ++CT+K+ DFGLAR+ G +T YV TR+YR
Sbjct: 125 TRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYR 184
Query: 193 APEVILGM-GYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 251
APEV+L Y VD+WS+GCI+GEM+ + LFPG + Q ++E + P E +
Sbjct: 185 APEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLA 244
Query: 252 L----QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDAS 307
L + +V + +RP+ D L P D+ + +A DLL ++LV
Sbjct: 245 LGSGCRASVLHQLGSRPRQT--------LDALLPPDT------SPEALDLLRRLLVFAPD 290
Query: 308 KRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMD 362
KR+S +ALQHPY+ ++ PS+ A + + + + ++ E++ +Y+ +++
Sbjct: 291 KRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILE 345
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,632,334
Number of Sequences: 37866
Number of extensions: 754349
Number of successful extensions: 4765
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 749
Number of HSP's successfully gapped in prelim test: 62
Number of HSP's that attempted gapping in prelim test: 2593
Number of HSP's gapped (non-prelim): 1169
length of query: 427
length of database: 18,247,518
effective HSP length: 105
effective length of query: 322
effective length of database: 14,271,588
effective search space: 4595451336
effective search space used: 4595451336
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.