BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta2 [Homo sapiens] (427 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta... 865 0.0 gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alph... 849 0.0 gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo ... 781 0.0 gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo ... 781 0.0 gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta... 771 0.0 gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha... 756 0.0 gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo s... 714 0.0 gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alph... 714 0.0 gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta... 707 0.0 gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alph... 662 0.0 gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta... 655 0.0 gi|20986508 mitogen-activated protein kinase 10 isoform 4 [Homo ... 516 e-146 gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gam... 418 e-117 gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens] 334 1e-91 gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ... 323 1e-88 gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens] 320 2e-87 gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo s... 316 2e-86 gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens] 312 3e-85 gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo ... 281 8e-76 gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo ... 276 2e-74 gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens] 256 3e-68 gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens] 256 3e-68 gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s... 254 1e-67 gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s... 249 3e-66 gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s... 244 1e-64 gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ... 244 1e-64 gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ... 244 1e-64 gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo ... 204 2e-52 gi|149408126 nemo like kinase [Homo sapiens] 203 3e-52 gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens] 202 5e-52 >gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta2 [Homo sapiens] Length = 427 Score = 865 bits (2234), Expect = 0.0 Identities = 427/427 (100%), Positives = 427/427 (100%) Query: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP Sbjct: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60 Query: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120 Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240 Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300 Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360 Query: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA Sbjct: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420 Query: 421 GPLGCCR 427 GPLGCCR Sbjct: 421 GPLGCCR 427 >gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alpha2 [Homo sapiens] Length = 427 Score = 849 bits (2194), Expect = 0.0 Identities = 419/427 (98%), Positives = 423/427 (99%) Query: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP Sbjct: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60 Query: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120 Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240 MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIMGEM+ +LFPG D+IDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240 Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300 Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360 Query: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA Sbjct: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420 Query: 421 GPLGCCR 427 GPLGCCR Sbjct: 421 GPLGCCR 427 >gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo sapiens] Length = 464 Score = 781 bits (2018), Expect = 0.0 Identities = 383/427 (89%), Positives = 405/427 (94%), Gaps = 1/427 (0%) Query: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60 MS+SK DN FYSVE+GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA+L+RNVAIKKLSRP Sbjct: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98 Query: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120 FQNQTHAKRAYRELVLMKCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVIQ Sbjct: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158 Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF Sbjct: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218 Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM++ +LFPG D+IDQWNKVIEQ Sbjct: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278 Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300 LGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHNKLKASQARDLLSK Sbjct: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338 Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360 MLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREHTIEEWKELIYKEV Sbjct: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398 Query: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420 M+ EE+TKNGV++GQPSP GAAV N S+ SSSVND+SSMSTD TLASDTDSSLEA+A Sbjct: 399 MNSEEKTKNGVVKGQPSPSGAAV-NSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASA 457 Query: 421 GPLGCCR 427 GPLGCCR Sbjct: 458 GPLGCCR 464 >gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo sapiens] Length = 426 Score = 781 bits (2018), Expect = 0.0 Identities = 383/427 (89%), Positives = 405/427 (94%), Gaps = 1/427 (0%) Query: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60 MS+SK DN FYSVE+GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA+L+RNVAIKKLSRP Sbjct: 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 60 Query: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120 FQNQTHAKRAYRELVLMKCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVIQ Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 120 Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM++ +LFPG D+IDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 240 Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300 LGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHNKLKASQARDLLSK Sbjct: 241 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 300 Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360 MLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREHTIEEWKELIYKEV Sbjct: 301 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 360 Query: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420 M+ EE+TKNGV++GQPSP GAAV N S+ SSSVND+SSMSTD TLASDTDSSLEA+A Sbjct: 361 MNSEEKTKNGVVKGQPSPSGAAV-NSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASA 419 Query: 421 GPLGCCR 427 GPLGCCR Sbjct: 420 GPLGCCR 426 >gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta1 [Homo sapiens] Length = 384 Score = 771 bits (1992), Expect = 0.0 Identities = 379/379 (100%), Positives = 379/379 (100%) Query: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP Sbjct: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60 Query: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120 Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240 Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300 Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360 Query: 361 MDLEERTKNGVIRGQPSPL 379 MDLEERTKNGVIRGQPSPL Sbjct: 361 MDLEERTKNGVIRGQPSPL 379 >gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha1 [Homo sapiens] Length = 384 Score = 756 bits (1952), Expect = 0.0 Identities = 371/379 (97%), Positives = 375/379 (98%) Query: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP Sbjct: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60 Query: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120 Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240 MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIMGEM+ +LFPG D+IDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240 Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300 Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360 Query: 361 MDLEERTKNGVIRGQPSPL 379 MDLEERTKNGVIRGQPSPL Sbjct: 361 MDLEERTKNGVIRGQPSPL 379 >gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo sapiens] Length = 422 Score = 714 bits (1844), Expect = 0.0 Identities = 345/378 (91%), Positives = 364/378 (96%) Query: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60 MS+SK DN FYSVE+GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA+L+RNVAIKKLSRP Sbjct: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98 Query: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120 FQNQTHAKRAYRELVLMKCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVIQ Sbjct: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158 Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF Sbjct: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218 Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM++ +LFPG D+IDQWNKVIEQ Sbjct: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278 Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300 LGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHNKLKASQARDLLSK Sbjct: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338 Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360 MLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREHTIEEWKELIYKEV Sbjct: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398 Query: 361 MDLEERTKNGVIRGQPSP 378 M+ EE+TKNGV++GQPSP Sbjct: 399 MNSEEKTKNGVVKGQPSP 416 >gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alpha2 [Homo sapiens] Length = 424 Score = 714 bits (1843), Expect = 0.0 Identities = 350/427 (81%), Positives = 384/427 (89%), Gaps = 3/427 (0%) Query: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60 MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L NVA+KKLSRP Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 Query: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120 FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE++KG V+F GTDHIDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240 Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300 LGTP EFMKKLQPTVR YVENRPKY G FE+LFPD +FP++SE +K+K SQARDLLSK Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300 Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360 MLVID KRISVDEAL+HPYI VWYDP+EAEAPPP+I D QL+EREH IEEWKELIYKEV Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360 Query: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420 MD EER+KNGV++ QPS A ++ + PS SSS+ND+SSMST+ TLASDTDSSL+A+ Sbjct: 361 MDWEERSKNGVVKDQPSD---AAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDAST 417 Query: 421 GPLGCCR 427 GPL CR Sbjct: 418 GPLEGCR 424 >gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta2 [Homo sapiens] Length = 424 Score = 707 bits (1824), Expect = 0.0 Identities = 348/427 (81%), Positives = 381/427 (89%), Gaps = 3/427 (0%) Query: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60 MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L NVA+KKLSRP Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 Query: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120 FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM EM+ VLFPG D+IDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240 Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300 LGTP EFMKKLQPTVR YVENRPKY G FE+LFPD +FP++SE +K+K SQARDLLSK Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300 Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360 MLVID KRISVDEAL+HPYI VWYDP+EAEAPPP+I D QL+EREH IEEWKELIYKEV Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360 Query: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420 MD EER+KNGV++ QPS A ++ + PS SSS+ND+SSMST+ TLASDTDSSL+A+ Sbjct: 361 MDWEERSKNGVVKDQPSD---AAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDAST 417 Query: 421 GPLGCCR 427 GPL CR Sbjct: 418 GPLEGCR 424 >gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alpha1 [Homo sapiens] Length = 382 Score = 662 bits (1709), Expect = 0.0 Identities = 321/377 (85%), Positives = 347/377 (92%) Query: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60 MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L NVA+KKLSRP Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 Query: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120 FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE++KG V+F GTDHIDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240 Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300 LGTP EFMKKLQPTVR YVENRPKY G FE+LFPD +FP++SE +K+K SQARDLLSK Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300 Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360 MLVID KRISVDEAL+HPYI VWYDP+EAEAPPP+I D QL+EREH IEEWKELIYKEV Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360 Query: 361 MDLEERTKNGVIRGQPS 377 MD EER+KNGV++ QPS Sbjct: 361 MDWEERSKNGVVKDQPS 377 >gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta1 [Homo sapiens] Length = 382 Score = 655 bits (1690), Expect = 0.0 Identities = 319/377 (84%), Positives = 344/377 (91%) Query: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60 MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L NVA+KKLSRP Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 Query: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120 FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM EM+ VLFPG D+IDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240 Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300 LGTP EFMKKLQPTVR YVENRPKY G FE+LFPD +FP++SE +K+K SQARDLLSK Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300 Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360 MLVID KRISVDEAL+HPYI VWYDP+EAEAPPP+I D QL+EREH IEEWKELIYKEV Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360 Query: 361 MDLEERTKNGVIRGQPS 377 MD EER+KNGV++ QPS Sbjct: 361 MDWEERSKNGVVKDQPS 377 >gi|20986508 mitogen-activated protein kinase 10 isoform 4 [Homo sapiens] Length = 277 Score = 516 bits (1330), Expect = e-146 Identities = 247/271 (91%), Positives = 260/271 (95%) Query: 108 MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 167 MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI Sbjct: 1 MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60 Query: 168 LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPG 227 LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM++ +LFPG Sbjct: 61 LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 120 Query: 228 TDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHN 287 D+IDQWNKVIEQLGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHN Sbjct: 121 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 180 Query: 288 KLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREH 347 KLKASQARDLLSKMLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREH Sbjct: 181 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 240 Query: 348 TIEEWKELIYKEVMDLEERTKNGVIRGQPSP 378 TIEEWKELIYKEVM+ EE+TKNGV++GQPSP Sbjct: 241 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSP 271 >gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gamma [Homo sapiens] Length = 242 Score = 418 bits (1075), Expect = e-117 Identities = 204/231 (88%), Positives = 217/231 (93%) Query: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60 MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L NVA+KKLSRP Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60 Query: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120 FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120 Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180 Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHI 231 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE++KG V+F GTD I Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDRI 231 >gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens] Length = 364 Score = 334 bits (856), Expect = 1e-91 Identities = 175/359 (48%), Positives = 244/359 (67%), Gaps = 21/359 (5%) Query: 10 FYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKR 69 FY E+ + + V +R Q L+P+GSGA G VC+AYDA L + VA+KKLSRPFQ+ HA+R Sbjct: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67 Query: 70 AYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERM 128 YREL L+K + H+N+IGLL+VFTP S+E+F +VY+V LM A+L +++ + L E + Sbjct: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127 Query: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 188 +L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A MT YV T Sbjct: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVAT 185 Query: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPE 247 R+YRAPE++L M Y + VDIWSVGCIM E+++G LFPG+D+IDQ +++E +GTP PE Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245 Query: 248 FMKKLQPT-VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDA 306 + K+ RTY+++ P +F N L A DLL +MLV+D+ Sbjct: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGA--------NPL----AIDLLGRMLVLDS 293 Query: 307 SKRISVDEALQHPYINVWYDP-SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLE 364 +R+S EAL H Y + ++DP E EA P D+ ++ +E T+EEWKEL Y+EV+ + Sbjct: 294 DQRVSAAEALAHAYFSQYHDPEDEPEAEP---YDESVEAKERTLEEWKELTYQEVLSFK 349 >gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo sapiens] Length = 360 Score = 323 bits (829), Expect = 1e-88 Identities = 175/361 (48%), Positives = 235/361 (65%), Gaps = 19/361 (5%) Query: 4 SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 63 S+ FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ Sbjct: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 Query: 64 QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-ME 122 HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V LM A+L +++ + Sbjct: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 Query: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182 L + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T M Sbjct: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179 Query: 183 TPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQL 241 T YV TR+YRAPE++L M Y + VDIWSVGCIM E++ G LFPGTDHIDQ ++ + Sbjct: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239 Query: 242 GTPCPEFMKKL-QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300 GTP E +KK+ + R Y+++ + +F +F N L A DLL K Sbjct: 240 GTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGA--------NPL----AVDLLEK 287 Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360 MLV+D+ KRI+ +AL H Y ++DP + P D+ + R+ I+EWK L Y EV Sbjct: 288 MLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPY--DQSFESRDLLIDEWKSLTYDEV 345 Query: 361 M 361 + Sbjct: 346 I 346 >gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens] Length = 365 Score = 320 bits (820), Expect = 2e-87 Identities = 169/360 (46%), Positives = 232/360 (64%), Gaps = 19/360 (5%) Query: 6 RDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQT 65 R FY ++ + + + K Y + +GSGA G VC+A D VAIKKLSRPFQ++ Sbjct: 5 RKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI 64 Query: 66 HAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDH 125 AKRAYREL+L+K + H+N+IGLL+VFTP SL F D Y+VM M +L +++ ME Sbjct: 65 FAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSE 124 Query: 126 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPY 185 E++ YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A MT Y Sbjct: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGY 182 Query: 186 VVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTP 244 VVTR+YRAPEVIL M Y + VDIWSVGCIM EM+ G LF G D++DQ ++++ G P Sbjct: 183 VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP 242 Query: 245 CPEFMKKL-QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLV 303 EF++KL ++Y+++ P+ F +LFP + QA DLL KML Sbjct: 243 GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA------------SPQAADLLEKMLE 290 Query: 304 IDASKRISVDEALQHPYINVWYDP-SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMD 362 +D KR++ +AL HP+ + DP E EA P D L+ + T++EWK+ IYKE+++ Sbjct: 291 LDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPF--DDSLEHEKLTVDEWKQHIYKEIVN 348 >gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo sapiens] Length = 360 Score = 316 bits (810), Expect = 2e-86 Identities = 173/362 (47%), Positives = 234/362 (64%), Gaps = 21/362 (5%) Query: 4 SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 63 S+ FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ Sbjct: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 Query: 64 QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-ME 122 HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V LM A+L +++ + Sbjct: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 Query: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182 L + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T M Sbjct: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179 Query: 183 TPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQL 241 T YV TR+YRAPE++L M Y + VDIWSVGCIM E++ G LFPGTDHI+Q +++ Sbjct: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLT 239 Query: 242 GTPCPEFMKKLQPT--VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLS 299 GTP P ++ P+ R Y+++ + +F +F N L A DLL Sbjct: 240 GTP-PAYLINRMPSHEARNYIQSLTQMPKMNFANVFIGA--------NPL----AVDLLE 286 Query: 300 KMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359 KMLV+D+ KRI+ +AL H Y ++DP + P D+ + R+ I+EWK L Y E Sbjct: 287 KMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPY--DQSFESRDLLIDEWKSLTYDE 344 Query: 360 VM 361 V+ Sbjct: 345 VI 346 >gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens] Length = 367 Score = 312 bits (800), Expect = 3e-85 Identities = 168/375 (44%), Positives = 241/375 (64%), Gaps = 19/375 (5%) Query: 8 NNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHA 67 + FY E+ + + V Y++L+P+GSGA G VC+A D VAIKKL RPFQ++ A Sbjct: 9 SGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA 68 Query: 68 KRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHE 126 KRAYREL L+K + H+N+IGLL+VFTP ++L++F D Y+VM M +L ++++ E L + Sbjct: 69 KRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED 128 Query: 127 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYV 186 R+ +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT YV Sbjct: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYV 186 Query: 187 VTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPC 245 VTR+YRAPEVIL M Y + VDIWSVGCIM EMI G LF G+DH+DQ ++++ GTP Sbjct: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246 Query: 246 PEFMKKLQ-PTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVI 304 EF+++LQ + Y++ P+ F + + + A +LL KMLV+ Sbjct: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTNA------------SPLAVNLLEKMLVL 294 Query: 305 DASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLE 364 DA +R++ EAL HPY +D + P + D D+ + T++EWK + YKEV+ + Sbjct: 295 DAEQRVTAGEALAHPYFESLHDTE--DEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFK 352 Query: 365 ERTKNGVIRGQPSPL 379 + G + +PL Sbjct: 353 PPRQLGARVSKETPL 367 >gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo sapiens] Length = 297 Score = 281 bits (719), Expect = 8e-76 Identities = 144/275 (52%), Positives = 192/275 (69%), Gaps = 5/275 (1%) Query: 4 SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 63 S+ FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ Sbjct: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 Query: 64 QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-ME 122 HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V LM A+L +++ + Sbjct: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 Query: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182 L + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T M Sbjct: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179 Query: 183 TPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQL 241 T YV TR+YRAPE++L M Y + VDIWSVGCIM E++ G LFPGTDHIDQ ++ + Sbjct: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239 Query: 242 GTPCPEFMKKL-QPTVRTYVENRPKYAGYSFEKLF 275 GTP E +KK+ + R Y+++ + +F +F Sbjct: 240 GTPGAELLKKISSESARNYIQSLTQMPKMNFANVF 274 >gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo sapiens] Length = 307 Score = 276 bits (707), Expect = 2e-74 Identities = 140/251 (55%), Positives = 181/251 (72%), Gaps = 4/251 (1%) Query: 4 SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 63 S+ FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ Sbjct: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 Query: 64 QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-ME 122 HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V LM A+L +++ + Sbjct: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 Query: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182 L + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T M Sbjct: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179 Query: 183 TPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQL 241 T YV TR+YRAPE++L M Y + VDIWSVGCIM E++ G LFPGTDHIDQ ++ + Sbjct: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239 Query: 242 GTPCPEFMKKL 252 GTP E +KK+ Sbjct: 240 GTPGAELLKKI 250 >gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens] Length = 360 Score = 256 bits (654), Expect = 3e-68 Identities = 147/348 (42%), Positives = 221/348 (63%), Gaps = 24/348 (6%) Query: 20 FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79 F V RY NL IG GA G+VC+AYD + + VAIKK+S PF++QT+ +R RE+ ++ Sbjct: 19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLR 77 Query: 80 VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLCG 138 H+NIIG+ ++ ++E+ +DVYIV +LM+ +L ++++ + L ++ + Y LYQ+L G Sbjct: 78 FRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRG 136 Query: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 194 +K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP Sbjct: 137 LKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAP 196 Query: 195 EVIL-GMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMK-KL 252 E++L GY +++DIWSVGCI+ EM+ +FPG ++DQ N ++ LG+P E + + Sbjct: 197 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 256 Query: 253 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 312 R Y+ + P + +LFP+ AD S+A DLL KML + KRI V Sbjct: 257 NLKARNYLLSLPHKNKVPWNRLFPN----AD--------SKALDLLDKMLTFNPHKRIEV 304 Query: 313 DEALQHPYINVWYDPS-EAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359 ++AL HPY+ +YDPS E A P D +LD+ E+ KELI++E Sbjct: 305 EQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350 >gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens] Length = 360 Score = 256 bits (654), Expect = 3e-68 Identities = 147/348 (42%), Positives = 221/348 (63%), Gaps = 24/348 (6%) Query: 20 FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79 F V RY NL IG GA G+VC+AYD + + VAIKK+S PF++QT+ +R RE+ ++ Sbjct: 19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLR 77 Query: 80 VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLCG 138 H+NIIG+ ++ ++E+ +DVYIV +LM+ +L ++++ + L ++ + Y LYQ+L G Sbjct: 78 FRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRG 136 Query: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 194 +K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP Sbjct: 137 LKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAP 196 Query: 195 EVIL-GMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMK-KL 252 E++L GY +++DIWSVGCI+ EM+ +FPG ++DQ N ++ LG+P E + + Sbjct: 197 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 256 Query: 253 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 312 R Y+ + P + +LFP+ AD S+A DLL KML + KRI V Sbjct: 257 NLKARNYLLSLPHKNKVPWNRLFPN----AD--------SKALDLLDKMLTFNPHKRIEV 304 Query: 313 DEALQHPYINVWYDPS-EAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359 ++AL HPY+ +YDPS E A P D +LD+ E+ KELI++E Sbjct: 305 EQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350 >gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo sapiens] Length = 379 Score = 254 bits (648), Expect = 1e-67 Identities = 142/348 (40%), Positives = 218/348 (62%), Gaps = 24/348 (6%) Query: 20 FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79 F V RY L+ IG GA G+V +AYD + + VAIKK+S PF++QT+ +R RE+ ++ Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94 Query: 80 VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 138 H+N+IG+ ++ +LE +DVYIV +LM+ +L ++++ +L ++ + Y LYQ+L G Sbjct: 95 FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153 Query: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 194 +K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 Query: 195 EVIL-GMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMK-KL 252 E++L GY +++DIWSVGCI+ EM+ +FPG ++DQ N ++ LG+P E + + Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 Query: 253 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 312 R Y+++ P ++ KLFP S+A DLL +ML + +KRI+V Sbjct: 274 NMKARNYLQSLPSKTKVAWAKLFPK------------SDSKALDLLDRMLTFNPNKRITV 321 Query: 313 DEALQHPYINVWYDPS-EAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359 +EAL HPY+ +YDP+ E A P +LD+ E KELI++E Sbjct: 322 EEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 367 >gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo sapiens] Length = 357 Score = 249 bits (637), Expect = 3e-66 Identities = 132/323 (40%), Positives = 205/323 (63%), Gaps = 21/323 (6%) Query: 20 FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79 F V RY L+ IG GA G+V +AYD + + VAIKK+S PF++QT+ +R RE+ ++ Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94 Query: 80 VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 138 H+N+IG+ ++ +LE +DVYIV +LM+ +L ++++ +L ++ + Y LYQ+L G Sbjct: 95 FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153 Query: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 194 +K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 Query: 195 EVIL-GMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMK-KL 252 E++L GY +++DIWSVGCI+ EM+ +FPG ++DQ N ++ LG+P E + + Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 Query: 253 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 312 R Y+++ P ++ KLFP S+A DLL +ML + +KRI+V Sbjct: 274 NMKARNYLQSLPSKTKVAWAKLFPK------------SDSKALDLLDRMLTFNPNKRITV 321 Query: 313 DEALQHPYINVWYDPSEAEAPPP 335 +EAL HPY+ +YDP++ P Sbjct: 322 EEALAHPYLEQYYDPTDEVGQSP 344 >gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo sapiens] Length = 816 Score = 244 bits (622), Expect = 1e-64 Identities = 150/374 (40%), Positives = 217/374 (58%), Gaps = 28/374 (7%) Query: 17 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVL 76 D TF V Y+ ++ IG+GA G+V +A + + VAIKK+ F T+AKR REL + Sbjct: 46 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105 Query: 77 MKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVI--QMELDHERMSYLLYQ 134 +K H NII + ++ P EF+ VY+V++LM+++L Q+I L E + Y LYQ Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165 Query: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS-----FMMTPYVVTR 189 +L G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR TS + MT YV TR Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225 Query: 190 YYRAPEVILGM-GYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEF 248 +YRAPE++L + Y + +D+WSVGCI GEM+ LFPG +++ Q ++ LGTP P Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285 Query: 249 MKKL-QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDAS 307 ++ + VR Y+++ P +E ++P AD QA LL +ML + S Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPG----AD--------RQALSLLGRMLRFEPS 333 Query: 308 KRISVDEALQHPYINVWYDP-SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEER 366 RIS AL+HP++ ++DP E + PP D D T E KE I E+ D R Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPPF--DFAFDREALTRERIKEAIVAEIEDFHAR 391 Query: 367 TKNGV---IRGQPS 377 + G+ IR QPS Sbjct: 392 -REGIRQQIRFQPS 404 >gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo sapiens] Length = 816 Score = 244 bits (622), Expect = 1e-64 Identities = 150/374 (40%), Positives = 217/374 (58%), Gaps = 28/374 (7%) Query: 17 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVL 76 D TF V Y+ ++ IG+GA G+V +A + + VAIKK+ F T+AKR REL + Sbjct: 46 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105 Query: 77 MKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVI--QMELDHERMSYLLYQ 134 +K H NII + ++ P EF+ VY+V++LM+++L Q+I L E + Y LYQ Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165 Query: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS-----FMMTPYVVTR 189 +L G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR TS + MT YV TR Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225 Query: 190 YYRAPEVILGM-GYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEF 248 +YRAPE++L + Y + +D+WSVGCI GEM+ LFPG +++ Q ++ LGTP P Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285 Query: 249 MKKL-QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDAS 307 ++ + VR Y+++ P +E ++P AD QA LL +ML + S Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPG----AD--------RQALSLLGRMLRFEPS 333 Query: 308 KRISVDEALQHPYINVWYDP-SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEER 366 RIS AL+HP++ ++DP E + PP D D T E KE I E+ D R Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPPF--DFAFDREALTRERIKEAIVAEIEDFHAR 391 Query: 367 TKNGV---IRGQPS 377 + G+ IR QPS Sbjct: 392 -REGIRQQIRFQPS 404 >gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo sapiens] Length = 816 Score = 244 bits (622), Expect = 1e-64 Identities = 150/374 (40%), Positives = 217/374 (58%), Gaps = 28/374 (7%) Query: 17 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVL 76 D TF V Y+ ++ IG+GA G+V +A + + VAIKK+ F T+AKR REL + Sbjct: 46 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105 Query: 77 MKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVI--QMELDHERMSYLLYQ 134 +K H NII + ++ P EF+ VY+V++LM+++L Q+I L E + Y LYQ Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165 Query: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS-----FMMTPYVVTR 189 +L G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR TS + MT YV TR Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225 Query: 190 YYRAPEVILGM-GYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEF 248 +YRAPE++L + Y + +D+WSVGCI GEM+ LFPG +++ Q ++ LGTP P Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285 Query: 249 MKKL-QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDAS 307 ++ + VR Y+++ P +E ++P AD QA LL +ML + S Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPG----AD--------RQALSLLGRMLRFEPS 333 Query: 308 KRISVDEALQHPYINVWYDP-SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEER 366 RIS AL+HP++ ++DP E + PP D D T E KE I E+ D R Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPPF--DFAFDREALTRERIKEAIVAEIEDFHAR 391 Query: 367 TKNGV---IRGQPS 377 + G+ IR QPS Sbjct: 392 -REGIRQQIRFQPS 404 >gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo sapiens] Length = 335 Score = 204 bits (518), Expect = 2e-52 Identities = 126/347 (36%), Positives = 188/347 (54%), Gaps = 66/347 (19%) Query: 20 FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79 F V RY L+ IG GA G+V +AYD + + VAIKK+S PF++QT+ +R RE+ ++ Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94 Query: 80 VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 138 H+N+IG+ ++ +LE +DVYIV +LM+ +L ++++ +L ++ + Y LYQ+L G Sbjct: 95 FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153 Query: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 194 +K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 Query: 195 EVIL-GMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQ 253 E++L GY +++DIWSVGCI+ EM+ +FPG ++DQ N + L + M Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI---LALDLLDRMLTFN 270 Query: 254 PTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVD 313 P R VE Sbjct: 271 PNKRITVE---------------------------------------------------- 278 Query: 314 EALQHPYINVWYDPS-EAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359 EAL HPY+ +YDP+ E A P +LD+ E KELI++E Sbjct: 279 EALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 323 >gi|149408126 nemo like kinase [Homo sapiens] Length = 527 Score = 203 bits (516), Expect = 3e-52 Identities = 117/298 (39%), Positives = 175/298 (58%), Gaps = 16/298 (5%) Query: 30 KPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLL 89 +PIG GA G+V + D + VA+KK+ FQN KR +REL ++ H N++ L Sbjct: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201 Query: 90 NVFTPQKSLEEFQDVYIVMELMDANLCQVI--QMELDHERMSYLLYQMLCGIKHLHSAGI 147 ++ P ++ F+++Y+V ELM ++L ++I L + + LYQ+L G+K+LHSAGI Sbjct: 202 DILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260 Query: 148 IHRDLKPSNIVVKSDCTLKILDFGLART--AGTSFMMTPYVVTRYYRAPEVILGMGYKEN 205 +HRD+KP N++V S+C LKI DFGLAR S MT VVT+YYRAPE+++G + N Sbjct: 261 LHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSN 320 Query: 206 -VDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRP 264 +DIWSVGCI E++ +LF I Q + + + LGTP E M+ + ++ P Sbjct: 321 AIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGP 380 Query: 265 KYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYIN 322 ++ VL+ S+ +A LL +MLV D SKRIS +AL HPY++ Sbjct: 381 ------HKQPSLPVLYTLSSQ----ATHEAVHLLCRMLVFDPSKRISAKDALAHPYLD 428 >gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens] Length = 544 Score = 202 bits (514), Expect = 5e-52 Identities = 123/355 (34%), Positives = 201/355 (56%), Gaps = 32/355 (9%) Query: 22 VLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCV- 80 +++RY + +G GA GIV A D VAIKK+ F+++T A+R +RE+ L++ Sbjct: 9 IVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG 68 Query: 81 NHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME--LDHERMSYLLYQMLCG 138 +H NII LL+V + +D+Y+V E MD +L VI+ L + + YQ+L Sbjct: 69 DHPNIISLLDVIRAEND----RDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRA 124 Query: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG------TSFMMTPYVVTRYYR 192 + LHS ++HRD KPSN+++ ++CT+K+ DFGLAR+ G +T YV TR+YR Sbjct: 125 TRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYR 184 Query: 193 APEVILGM-GYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKK 251 APEV+L Y VD+WS+GCI+GEM++G LFPGT + Q ++E + P E + Sbjct: 185 APEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLA 244 Query: 252 L----QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDAS 307 L + +V + +RP+ D L P D+ + +A DLL ++LV Sbjct: 245 LGSGCRASVLHQLGSRPRQT--------LDALLPPDT------SPEALDLLRRLLVFAPD 290 Query: 308 KRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMD 362 KR+S +ALQHPY+ ++ PS+ A + + + + ++ E++ +Y+ +++ Sbjct: 291 KRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILE 345 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.318 0.135 0.399 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,634,150 Number of Sequences: 37866 Number of extensions: 752511 Number of successful extensions: 4855 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 754 Number of HSP's successfully gapped in prelim test: 65 Number of HSP's that attempted gapping in prelim test: 2622 Number of HSP's gapped (non-prelim): 1177 length of query: 427 length of database: 18,247,518 effective HSP length: 105 effective length of query: 322 effective length of database: 14,271,588 effective search space: 4595451336 effective search space used: 4595451336 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.