Guide to the Human Genome
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Search of human proteins with 20986521

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|20986521 mitogen-activated protein kinase 8 isoform JNK1
beta2 [Homo sapiens]
         (427 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta...   865   0.0  
gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alph...   849   0.0  
gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo ...   781   0.0  
gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo ...   781   0.0  
gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta...   771   0.0  
gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha...   756   0.0  
gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo s...   714   0.0  
gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alph...   714   0.0  
gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta...   707   0.0  
gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alph...   662   0.0  
gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta...   655   0.0  
gi|20986508 mitogen-activated protein kinase 10 isoform 4 [Homo ...   516   e-146
gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gam...   418   e-117
gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]        334   1e-91
gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ...   323   1e-88
gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]         320   2e-87
gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo s...   316   2e-86
gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]        312   3e-85
gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo ...   281   8e-76
gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo ...   276   2e-74
gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]         256   3e-68
gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]         256   3e-68
gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s...   254   1e-67
gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s...   249   3e-66
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s...   244   1e-64
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ...   244   1e-64
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ...   244   1e-64
gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo ...   204   2e-52
gi|149408126 nemo like kinase [Homo sapiens]                          203   3e-52
gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]        202   5e-52

>gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta2
           [Homo sapiens]
          Length = 427

 Score =  865 bits (2234), Expect = 0.0
 Identities = 427/427 (100%), Positives = 427/427 (100%)

Query: 1   MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
           MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
Sbjct: 1   MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60

Query: 61  FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
           FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
Sbjct: 61  FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120

Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180

Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240

Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
           LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300

Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
           MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360

Query: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420
           MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA
Sbjct: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420

Query: 421 GPLGCCR 427
           GPLGCCR
Sbjct: 421 GPLGCCR 427


>gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alpha2
           [Homo sapiens]
          Length = 427

 Score =  849 bits (2194), Expect = 0.0
 Identities = 419/427 (98%), Positives = 423/427 (99%)

Query: 1   MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
           MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
Sbjct: 1   MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60

Query: 61  FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
           FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
Sbjct: 61  FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120

Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180

Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240
           MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIMGEM+   +LFPG D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240

Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
           LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300

Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
           MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360

Query: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420
           MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA
Sbjct: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420

Query: 421 GPLGCCR 427
           GPLGCCR
Sbjct: 421 GPLGCCR 427


>gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo
           sapiens]
          Length = 464

 Score =  781 bits (2018), Expect = 0.0
 Identities = 383/427 (89%), Positives = 405/427 (94%), Gaps = 1/427 (0%)

Query: 1   MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
           MS+SK DN FYSVE+GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA+L+RNVAIKKLSRP
Sbjct: 39  MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98

Query: 61  FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
           FQNQTHAKRAYRELVLMKCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVIQ
Sbjct: 99  FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158

Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
Sbjct: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218

Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM++  +LFPG D+IDQWNKVIEQ
Sbjct: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278

Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
           LGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHNKLKASQARDLLSK
Sbjct: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338

Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
           MLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREHTIEEWKELIYKEV
Sbjct: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398

Query: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420
           M+ EE+TKNGV++GQPSP GAAV N S+    SSSVND+SSMSTD TLASDTDSSLEA+A
Sbjct: 399 MNSEEKTKNGVVKGQPSPSGAAV-NSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASA 457

Query: 421 GPLGCCR 427
           GPLGCCR
Sbjct: 458 GPLGCCR 464


>gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo
           sapiens]
          Length = 426

 Score =  781 bits (2018), Expect = 0.0
 Identities = 383/427 (89%), Positives = 405/427 (94%), Gaps = 1/427 (0%)

Query: 1   MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
           MS+SK DN FYSVE+GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA+L+RNVAIKKLSRP
Sbjct: 1   MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 60

Query: 61  FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
           FQNQTHAKRAYRELVLMKCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVIQ
Sbjct: 61  FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 120

Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180

Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM++  +LFPG D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 240

Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
           LGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHNKLKASQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 300

Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
           MLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREHTIEEWKELIYKEV
Sbjct: 301 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 360

Query: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420
           M+ EE+TKNGV++GQPSP GAAV N S+    SSSVND+SSMSTD TLASDTDSSLEA+A
Sbjct: 361 MNSEEKTKNGVVKGQPSPSGAAV-NSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASA 419

Query: 421 GPLGCCR 427
           GPLGCCR
Sbjct: 420 GPLGCCR 426


>gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta1
           [Homo sapiens]
          Length = 384

 Score =  771 bits (1992), Expect = 0.0
 Identities = 379/379 (100%), Positives = 379/379 (100%)

Query: 1   MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
           MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
Sbjct: 1   MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60

Query: 61  FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
           FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
Sbjct: 61  FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120

Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180

Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240

Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
           LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300

Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
           MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360

Query: 361 MDLEERTKNGVIRGQPSPL 379
           MDLEERTKNGVIRGQPSPL
Sbjct: 361 MDLEERTKNGVIRGQPSPL 379


>gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha1
           [Homo sapiens]
          Length = 384

 Score =  756 bits (1952), Expect = 0.0
 Identities = 371/379 (97%), Positives = 375/379 (98%)

Query: 1   MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
           MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
Sbjct: 1   MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60

Query: 61  FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
           FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
Sbjct: 61  FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120

Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180

Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240
           MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIMGEM+   +LFPG D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240

Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
           LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300

Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
           MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360

Query: 361 MDLEERTKNGVIRGQPSPL 379
           MDLEERTKNGVIRGQPSPL
Sbjct: 361 MDLEERTKNGVIRGQPSPL 379


>gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo
           sapiens]
          Length = 422

 Score =  714 bits (1844), Expect = 0.0
 Identities = 345/378 (91%), Positives = 364/378 (96%)

Query: 1   MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
           MS+SK DN FYSVE+GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA+L+RNVAIKKLSRP
Sbjct: 39  MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98

Query: 61  FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
           FQNQTHAKRAYRELVLMKCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVIQ
Sbjct: 99  FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158

Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
Sbjct: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218

Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM++  +LFPG D+IDQWNKVIEQ
Sbjct: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278

Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
           LGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHNKLKASQARDLLSK
Sbjct: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338

Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
           MLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREHTIEEWKELIYKEV
Sbjct: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398

Query: 361 MDLEERTKNGVIRGQPSP 378
           M+ EE+TKNGV++GQPSP
Sbjct: 399 MNSEEKTKNGVVKGQPSP 416


>gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alpha2
           [Homo sapiens]
          Length = 424

 Score =  714 bits (1843), Expect = 0.0
 Identities = 350/427 (81%), Positives = 384/427 (89%), Gaps = 3/427 (0%)

Query: 1   MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
           MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L  NVA+KKLSRP
Sbjct: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60

Query: 61  FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
           FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI 
Sbjct: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120

Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180

Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE++KG V+F GTDHIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240

Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
           LGTP  EFMKKLQPTVR YVENRPKY G  FE+LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300

Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
           MLVID  KRISVDEAL+HPYI VWYDP+EAEAPPP+I D QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360

Query: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420
           MD EER+KNGV++ QPS    A ++ +  PS SSS+ND+SSMST+ TLASDTDSSL+A+ 
Sbjct: 361 MDWEERSKNGVVKDQPSD---AAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDAST 417

Query: 421 GPLGCCR 427
           GPL  CR
Sbjct: 418 GPLEGCR 424


>gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta2
           [Homo sapiens]
          Length = 424

 Score =  707 bits (1824), Expect = 0.0
 Identities = 348/427 (81%), Positives = 381/427 (89%), Gaps = 3/427 (0%)

Query: 1   MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
           MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L  NVA+KKLSRP
Sbjct: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60

Query: 61  FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
           FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI 
Sbjct: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120

Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180

Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM EM+   VLFPG D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240

Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
           LGTP  EFMKKLQPTVR YVENRPKY G  FE+LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300

Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
           MLVID  KRISVDEAL+HPYI VWYDP+EAEAPPP+I D QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360

Query: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420
           MD EER+KNGV++ QPS    A ++ +  PS SSS+ND+SSMST+ TLASDTDSSL+A+ 
Sbjct: 361 MDWEERSKNGVVKDQPSD---AAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDAST 417

Query: 421 GPLGCCR 427
           GPL  CR
Sbjct: 418 GPLEGCR 424


>gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alpha1
           [Homo sapiens]
          Length = 382

 Score =  662 bits (1709), Expect = 0.0
 Identities = 321/377 (85%), Positives = 347/377 (92%)

Query: 1   MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
           MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L  NVA+KKLSRP
Sbjct: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60

Query: 61  FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
           FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI 
Sbjct: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120

Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180

Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE++KG V+F GTDHIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240

Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
           LGTP  EFMKKLQPTVR YVENRPKY G  FE+LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300

Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
           MLVID  KRISVDEAL+HPYI VWYDP+EAEAPPP+I D QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360

Query: 361 MDLEERTKNGVIRGQPS 377
           MD EER+KNGV++ QPS
Sbjct: 361 MDWEERSKNGVVKDQPS 377


>gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta1
           [Homo sapiens]
          Length = 382

 Score =  655 bits (1690), Expect = 0.0
 Identities = 319/377 (84%), Positives = 344/377 (91%)

Query: 1   MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
           MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L  NVA+KKLSRP
Sbjct: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60

Query: 61  FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
           FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI 
Sbjct: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120

Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180

Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM EM+   VLFPG D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240

Query: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
           LGTP  EFMKKLQPTVR YVENRPKY G  FE+LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300

Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
           MLVID  KRISVDEAL+HPYI VWYDP+EAEAPPP+I D QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360

Query: 361 MDLEERTKNGVIRGQPS 377
           MD EER+KNGV++ QPS
Sbjct: 361 MDWEERSKNGVVKDQPS 377


>gi|20986508 mitogen-activated protein kinase 10 isoform 4 [Homo
           sapiens]
          Length = 277

 Score =  516 bits (1330), Expect = e-146
 Identities = 247/271 (91%), Positives = 260/271 (95%)

Query: 108 MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 167
           MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI
Sbjct: 1   MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60

Query: 168 LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPG 227
           LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM++  +LFPG
Sbjct: 61  LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 120

Query: 228 TDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHN 287
            D+IDQWNKVIEQLGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHN
Sbjct: 121 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 180

Query: 288 KLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREH 347
           KLKASQARDLLSKMLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREH
Sbjct: 181 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 240

Query: 348 TIEEWKELIYKEVMDLEERTKNGVIRGQPSP 378
           TIEEWKELIYKEVM+ EE+TKNGV++GQPSP
Sbjct: 241 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSP 271


>gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gamma
           [Homo sapiens]
          Length = 242

 Score =  418 bits (1075), Expect = e-117
 Identities = 204/231 (88%), Positives = 217/231 (93%)

Query: 1   MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
           MS SK D+ FYSV++ DSTFTVLKRYQ LKPIGSGAQGIVCAA+D +L  NVA+KKLSRP
Sbjct: 1   MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60

Query: 61  FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
           FQNQTHAKRAYRELVL+KCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI 
Sbjct: 61  FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120

Query: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
           MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180

Query: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHI 231
           MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE++KG V+F GTD I
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDRI 231


>gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
          Length = 364

 Score =  334 bits (856), Expect = 1e-91
 Identities = 175/359 (48%), Positives = 244/359 (67%), Gaps = 21/359 (5%)

Query: 10  FYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKR 69
           FY  E+  + + V +R Q L+P+GSGA G VC+AYDA L + VA+KKLSRPFQ+  HA+R
Sbjct: 8   FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67

Query: 70  AYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERM 128
            YREL L+K + H+N+IGLL+VFTP  S+E+F +VY+V  LM A+L  +++ + L  E +
Sbjct: 68  TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127

Query: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 188
            +L+YQ+L G+K++HSAGIIHRDLKPSN+ V  DC L+ILDFGLAR A     MT YV T
Sbjct: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVAT 185

Query: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPE 247
           R+YRAPE++L  M Y + VDIWSVGCIM E+++G  LFPG+D+IDQ  +++E +GTP PE
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245

Query: 248 FMKKLQPT-VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDA 306
            + K+     RTY+++ P         +F           N L    A DLL +MLV+D+
Sbjct: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGA--------NPL----AIDLLGRMLVLDS 293

Query: 307 SKRISVDEALQHPYINVWYDP-SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLE 364
            +R+S  EAL H Y + ++DP  E EA P    D+ ++ +E T+EEWKEL Y+EV+  +
Sbjct: 294 DQRVSAAEALAHAYFSQYHDPEDEPEAEP---YDESVEAKERTLEEWKELTYQEVLSFK 349


>gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo
           sapiens]
          Length = 360

 Score =  323 bits (829), Expect = 1e-88
 Identities = 175/361 (48%), Positives = 235/361 (65%), Gaps = 19/361 (5%)

Query: 4   SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 63
           S+    FY  E+  + + V +RYQNL P+GSGA G VCAA+D      VA+KKLSRPFQ+
Sbjct: 2   SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61

Query: 64  QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-ME 122
             HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V  LM A+L  +++  +
Sbjct: 62  IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121

Query: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182
           L  + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKILDFGLAR   T   M
Sbjct: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179

Query: 183 TPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQL 241
           T YV TR+YRAPE++L  M Y + VDIWSVGCIM E++ G  LFPGTDHIDQ   ++  +
Sbjct: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239

Query: 242 GTPCPEFMKKL-QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
           GTP  E +KK+   + R Y+++  +    +F  +F           N L    A DLL K
Sbjct: 240 GTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGA--------NPL----AVDLLEK 287

Query: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
           MLV+D+ KRI+  +AL H Y   ++DP +     P   D+  + R+  I+EWK L Y EV
Sbjct: 288 MLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPY--DQSFESRDLLIDEWKSLTYDEV 345

Query: 361 M 361
           +
Sbjct: 346 I 346


>gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]
          Length = 365

 Score =  320 bits (820), Expect = 2e-87
 Identities = 169/360 (46%), Positives = 232/360 (64%), Gaps = 19/360 (5%)

Query: 6   RDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQT 65
           R   FY  ++  + + + K Y +   +GSGA G VC+A D      VAIKKLSRPFQ++ 
Sbjct: 5   RKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI 64

Query: 66  HAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDH 125
            AKRAYREL+L+K + H+N+IGLL+VFTP  SL  F D Y+VM  M  +L +++ ME   
Sbjct: 65  FAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSE 124

Query: 126 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPY 185
           E++ YL+YQML G+K++HSAG++HRDLKP N+ V  DC LKILDFGLAR A     MT Y
Sbjct: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGY 182

Query: 186 VVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTP 244
           VVTR+YRAPEVIL  M Y + VDIWSVGCIM EM+ G  LF G D++DQ  ++++  G P
Sbjct: 183 VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP 242

Query: 245 CPEFMKKL-QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLV 303
             EF++KL     ++Y+++ P+     F +LFP              + QA DLL KML 
Sbjct: 243 GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA------------SPQAADLLEKMLE 290

Query: 304 IDASKRISVDEALQHPYINVWYDP-SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMD 362
           +D  KR++  +AL HP+   + DP  E EA  P   D  L+  + T++EWK+ IYKE+++
Sbjct: 291 LDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPF--DDSLEHEKLTVDEWKQHIYKEIVN 348


>gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo
           sapiens]
          Length = 360

 Score =  316 bits (810), Expect = 2e-86
 Identities = 173/362 (47%), Positives = 234/362 (64%), Gaps = 21/362 (5%)

Query: 4   SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 63
           S+    FY  E+  + + V +RYQNL P+GSGA G VCAA+D      VA+KKLSRPFQ+
Sbjct: 2   SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61

Query: 64  QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-ME 122
             HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V  LM A+L  +++  +
Sbjct: 62  IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121

Query: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182
           L  + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKILDFGLAR   T   M
Sbjct: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179

Query: 183 TPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQL 241
           T YV TR+YRAPE++L  M Y + VDIWSVGCIM E++ G  LFPGTDHI+Q  +++   
Sbjct: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLT 239

Query: 242 GTPCPEFMKKLQPT--VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLS 299
           GTP P ++    P+   R Y+++  +    +F  +F           N L    A DLL 
Sbjct: 240 GTP-PAYLINRMPSHEARNYIQSLTQMPKMNFANVFIGA--------NPL----AVDLLE 286

Query: 300 KMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359
           KMLV+D+ KRI+  +AL H Y   ++DP +     P   D+  + R+  I+EWK L Y E
Sbjct: 287 KMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPY--DQSFESRDLLIDEWKSLTYDE 344

Query: 360 VM 361
           V+
Sbjct: 345 VI 346


>gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]
          Length = 367

 Score =  312 bits (800), Expect = 3e-85
 Identities = 168/375 (44%), Positives = 241/375 (64%), Gaps = 19/375 (5%)

Query: 8   NNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHA 67
           + FY  E+  + + V   Y++L+P+GSGA G VC+A D      VAIKKL RPFQ++  A
Sbjct: 9   SGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA 68

Query: 68  KRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHE 126
           KRAYREL L+K + H+N+IGLL+VFTP ++L++F D Y+VM  M  +L ++++ E L  +
Sbjct: 69  KRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED 128

Query: 127 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYV 186
           R+ +L+YQML G++++H+AGIIHRDLKP N+ V  DC LKILDFGLAR A +   MT YV
Sbjct: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYV 186

Query: 187 VTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPC 245
           VTR+YRAPEVIL  M Y + VDIWSVGCIM EMI G  LF G+DH+DQ  ++++  GTP 
Sbjct: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246

Query: 246 PEFMKKLQ-PTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVI 304
            EF+++LQ    + Y++  P+     F  +  +             +  A +LL KMLV+
Sbjct: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTNA------------SPLAVNLLEKMLVL 294

Query: 305 DASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLE 364
           DA +R++  EAL HPY    +D    + P  +  D   D+ + T++EWK + YKEV+  +
Sbjct: 295 DAEQRVTAGEALAHPYFESLHDTE--DEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFK 352

Query: 365 ERTKNGVIRGQPSPL 379
              + G    + +PL
Sbjct: 353 PPRQLGARVSKETPL 367


>gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo
           sapiens]
          Length = 297

 Score =  281 bits (719), Expect = 8e-76
 Identities = 144/275 (52%), Positives = 192/275 (69%), Gaps = 5/275 (1%)

Query: 4   SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 63
           S+    FY  E+  + + V +RYQNL P+GSGA G VCAA+D      VA+KKLSRPFQ+
Sbjct: 2   SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61

Query: 64  QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-ME 122
             HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V  LM A+L  +++  +
Sbjct: 62  IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121

Query: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182
           L  + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKILDFGLAR   T   M
Sbjct: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179

Query: 183 TPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQL 241
           T YV TR+YRAPE++L  M Y + VDIWSVGCIM E++ G  LFPGTDHIDQ   ++  +
Sbjct: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239

Query: 242 GTPCPEFMKKL-QPTVRTYVENRPKYAGYSFEKLF 275
           GTP  E +KK+   + R Y+++  +    +F  +F
Sbjct: 240 GTPGAELLKKISSESARNYIQSLTQMPKMNFANVF 274


>gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo
           sapiens]
          Length = 307

 Score =  276 bits (707), Expect = 2e-74
 Identities = 140/251 (55%), Positives = 181/251 (72%), Gaps = 4/251 (1%)

Query: 4   SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 63
           S+    FY  E+  + + V +RYQNL P+GSGA G VCAA+D      VA+KKLSRPFQ+
Sbjct: 2   SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61

Query: 64  QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-ME 122
             HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V  LM A+L  +++  +
Sbjct: 62  IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121

Query: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182
           L  + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKILDFGLAR   T   M
Sbjct: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179

Query: 183 TPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQL 241
           T YV TR+YRAPE++L  M Y + VDIWSVGCIM E++ G  LFPGTDHIDQ   ++  +
Sbjct: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239

Query: 242 GTPCPEFMKKL 252
           GTP  E +KK+
Sbjct: 240 GTPGAELLKKI 250


>gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]
          Length = 360

 Score =  256 bits (654), Expect = 3e-68
 Identities = 147/348 (42%), Positives = 221/348 (63%), Gaps = 24/348 (6%)

Query: 20  FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79
           F V  RY NL  IG GA G+VC+AYD + +  VAIKK+S PF++QT+ +R  RE+ ++  
Sbjct: 19  FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLR 77

Query: 80  VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLCG 138
             H+NIIG+ ++     ++E+ +DVYIV +LM+ +L ++++ + L ++ + Y LYQ+L G
Sbjct: 78  FRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRG 136

Query: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 194
           +K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A         +T YV TR+YRAP
Sbjct: 137 LKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAP 196

Query: 195 EVIL-GMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMK-KL 252
           E++L   GY +++DIWSVGCI+ EM+    +FPG  ++DQ N ++  LG+P  E +   +
Sbjct: 197 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 256

Query: 253 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 312
               R Y+ + P      + +LFP+    AD        S+A DLL KML  +  KRI V
Sbjct: 257 NLKARNYLLSLPHKNKVPWNRLFPN----AD--------SKALDLLDKMLTFNPHKRIEV 304

Query: 313 DEALQHPYINVWYDPS-EAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359
           ++AL HPY+  +YDPS E  A  P   D +LD+     E+ KELI++E
Sbjct: 305 EQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350


>gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]
          Length = 360

 Score =  256 bits (654), Expect = 3e-68
 Identities = 147/348 (42%), Positives = 221/348 (63%), Gaps = 24/348 (6%)

Query: 20  FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79
           F V  RY NL  IG GA G+VC+AYD + +  VAIKK+S PF++QT+ +R  RE+ ++  
Sbjct: 19  FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLR 77

Query: 80  VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLCG 138
             H+NIIG+ ++     ++E+ +DVYIV +LM+ +L ++++ + L ++ + Y LYQ+L G
Sbjct: 78  FRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRG 136

Query: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 194
           +K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A         +T YV TR+YRAP
Sbjct: 137 LKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAP 196

Query: 195 EVIL-GMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMK-KL 252
           E++L   GY +++DIWSVGCI+ EM+    +FPG  ++DQ N ++  LG+P  E +   +
Sbjct: 197 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 256

Query: 253 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 312
               R Y+ + P      + +LFP+    AD        S+A DLL KML  +  KRI V
Sbjct: 257 NLKARNYLLSLPHKNKVPWNRLFPN----AD--------SKALDLLDKMLTFNPHKRIEV 304

Query: 313 DEALQHPYINVWYDPS-EAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359
           ++AL HPY+  +YDPS E  A  P   D +LD+     E+ KELI++E
Sbjct: 305 EQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350


>gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo
           sapiens]
          Length = 379

 Score =  254 bits (648), Expect = 1e-67
 Identities = 142/348 (40%), Positives = 218/348 (62%), Gaps = 24/348 (6%)

Query: 20  FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79
           F V  RY  L+ IG GA G+V +AYD + +  VAIKK+S PF++QT+ +R  RE+ ++  
Sbjct: 36  FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94

Query: 80  VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 138
             H+N+IG+ ++     +LE  +DVYIV +LM+ +L ++++  +L ++ + Y LYQ+L G
Sbjct: 95  FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153

Query: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 194
           +K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A         +T YV TR+YRAP
Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213

Query: 195 EVIL-GMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMK-KL 252
           E++L   GY +++DIWSVGCI+ EM+    +FPG  ++DQ N ++  LG+P  E +   +
Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273

Query: 253 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 312
               R Y+++ P     ++ KLFP               S+A DLL +ML  + +KRI+V
Sbjct: 274 NMKARNYLQSLPSKTKVAWAKLFPK------------SDSKALDLLDRMLTFNPNKRITV 321

Query: 313 DEALQHPYINVWYDPS-EAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359
           +EAL HPY+  +YDP+ E  A  P     +LD+     E  KELI++E
Sbjct: 322 EEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 367


>gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo
           sapiens]
          Length = 357

 Score =  249 bits (637), Expect = 3e-66
 Identities = 132/323 (40%), Positives = 205/323 (63%), Gaps = 21/323 (6%)

Query: 20  FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79
           F V  RY  L+ IG GA G+V +AYD + +  VAIKK+S PF++QT+ +R  RE+ ++  
Sbjct: 36  FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94

Query: 80  VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 138
             H+N+IG+ ++     +LE  +DVYIV +LM+ +L ++++  +L ++ + Y LYQ+L G
Sbjct: 95  FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153

Query: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 194
           +K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A         +T YV TR+YRAP
Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213

Query: 195 EVIL-GMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMK-KL 252
           E++L   GY +++DIWSVGCI+ EM+    +FPG  ++DQ N ++  LG+P  E +   +
Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273

Query: 253 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 312
               R Y+++ P     ++ KLFP               S+A DLL +ML  + +KRI+V
Sbjct: 274 NMKARNYLQSLPSKTKVAWAKLFPK------------SDSKALDLLDRMLTFNPNKRITV 321

Query: 313 DEALQHPYINVWYDPSEAEAPPP 335
           +EAL HPY+  +YDP++     P
Sbjct: 322 EEALAHPYLEQYYDPTDEVGQSP 344


>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
           sapiens]
          Length = 816

 Score =  244 bits (622), Expect = 1e-64
 Identities = 150/374 (40%), Positives = 217/374 (58%), Gaps = 28/374 (7%)

Query: 17  DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVL 76
           D TF V   Y+ ++ IG+GA G+V +A   +  + VAIKK+   F   T+AKR  REL +
Sbjct: 46  DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105

Query: 77  MKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVI--QMELDHERMSYLLYQ 134
           +K   H NII + ++  P     EF+ VY+V++LM+++L Q+I     L  E + Y LYQ
Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165

Query: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS-----FMMTPYVVTR 189
           +L G+K++HSA +IHRDLKPSN++V  +C LKI DFG+AR   TS     + MT YV TR
Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225

Query: 190 YYRAPEVILGM-GYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEF 248
           +YRAPE++L +  Y + +D+WSVGCI GEM+    LFPG +++ Q   ++  LGTP P  
Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285

Query: 249 MKKL-QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDAS 307
           ++ +    VR Y+++ P      +E ++P     AD         QA  LL +ML  + S
Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPG----AD--------RQALSLLGRMLRFEPS 333

Query: 308 KRISVDEALQHPYINVWYDP-SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEER 366
            RIS   AL+HP++  ++DP  E +  PP   D   D    T E  KE I  E+ D   R
Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPPF--DFAFDREALTRERIKEAIVAEIEDFHAR 391

Query: 367 TKNGV---IRGQPS 377
            + G+   IR QPS
Sbjct: 392 -REGIRQQIRFQPS 404


>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
           sapiens]
          Length = 816

 Score =  244 bits (622), Expect = 1e-64
 Identities = 150/374 (40%), Positives = 217/374 (58%), Gaps = 28/374 (7%)

Query: 17  DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVL 76
           D TF V   Y+ ++ IG+GA G+V +A   +  + VAIKK+   F   T+AKR  REL +
Sbjct: 46  DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105

Query: 77  MKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVI--QMELDHERMSYLLYQ 134
           +K   H NII + ++  P     EF+ VY+V++LM+++L Q+I     L  E + Y LYQ
Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165

Query: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS-----FMMTPYVVTR 189
           +L G+K++HSA +IHRDLKPSN++V  +C LKI DFG+AR   TS     + MT YV TR
Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225

Query: 190 YYRAPEVILGM-GYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEF 248
           +YRAPE++L +  Y + +D+WSVGCI GEM+    LFPG +++ Q   ++  LGTP P  
Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285

Query: 249 MKKL-QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDAS 307
           ++ +    VR Y+++ P      +E ++P     AD         QA  LL +ML  + S
Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPG----AD--------RQALSLLGRMLRFEPS 333

Query: 308 KRISVDEALQHPYINVWYDP-SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEER 366
            RIS   AL+HP++  ++DP  E +  PP   D   D    T E  KE I  E+ D   R
Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPPF--DFAFDREALTRERIKEAIVAEIEDFHAR 391

Query: 367 TKNGV---IRGQPS 377
            + G+   IR QPS
Sbjct: 392 -REGIRQQIRFQPS 404


>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
           sapiens]
          Length = 816

 Score =  244 bits (622), Expect = 1e-64
 Identities = 150/374 (40%), Positives = 217/374 (58%), Gaps = 28/374 (7%)

Query: 17  DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVL 76
           D TF V   Y+ ++ IG+GA G+V +A   +  + VAIKK+   F   T+AKR  REL +
Sbjct: 46  DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105

Query: 77  MKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVI--QMELDHERMSYLLYQ 134
           +K   H NII + ++  P     EF+ VY+V++LM+++L Q+I     L  E + Y LYQ
Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165

Query: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS-----FMMTPYVVTR 189
           +L G+K++HSA +IHRDLKPSN++V  +C LKI DFG+AR   TS     + MT YV TR
Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225

Query: 190 YYRAPEVILGM-GYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEF 248
           +YRAPE++L +  Y + +D+WSVGCI GEM+    LFPG +++ Q   ++  LGTP P  
Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285

Query: 249 MKKL-QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDAS 307
           ++ +    VR Y+++ P      +E ++P     AD         QA  LL +ML  + S
Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPG----AD--------RQALSLLGRMLRFEPS 333

Query: 308 KRISVDEALQHPYINVWYDP-SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEER 366
            RIS   AL+HP++  ++DP  E +  PP   D   D    T E  KE I  E+ D   R
Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPPF--DFAFDREALTRERIKEAIVAEIEDFHAR 391

Query: 367 TKNGV---IRGQPS 377
            + G+   IR QPS
Sbjct: 392 -REGIRQQIRFQPS 404


>gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo
           sapiens]
          Length = 335

 Score =  204 bits (518), Expect = 2e-52
 Identities = 126/347 (36%), Positives = 188/347 (54%), Gaps = 66/347 (19%)

Query: 20  FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79
           F V  RY  L+ IG GA G+V +AYD + +  VAIKK+S PF++QT+ +R  RE+ ++  
Sbjct: 36  FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94

Query: 80  VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 138
             H+N+IG+ ++     +LE  +DVYIV +LM+ +L ++++  +L ++ + Y LYQ+L G
Sbjct: 95  FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153

Query: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 194
           +K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A         +T YV TR+YRAP
Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213

Query: 195 EVIL-GMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQ 253
           E++L   GY +++DIWSVGCI+ EM+    +FPG  ++DQ N +   L     + M    
Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI---LALDLLDRMLTFN 270

Query: 254 PTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVD 313
           P  R  VE                                                    
Sbjct: 271 PNKRITVE---------------------------------------------------- 278

Query: 314 EALQHPYINVWYDPS-EAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359
           EAL HPY+  +YDP+ E  A  P     +LD+     E  KELI++E
Sbjct: 279 EALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 323


>gi|149408126 nemo like kinase [Homo sapiens]
          Length = 527

 Score =  203 bits (516), Expect = 3e-52
 Identities = 117/298 (39%), Positives = 175/298 (58%), Gaps = 16/298 (5%)

Query: 30  KPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLL 89
           +PIG GA G+V +  D    + VA+KK+   FQN    KR +REL ++    H N++  L
Sbjct: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201

Query: 90  NVFTPQKSLEEFQDVYIVMELMDANLCQVI--QMELDHERMSYLLYQMLCGIKHLHSAGI 147
           ++  P   ++ F+++Y+V ELM ++L ++I     L  + +   LYQ+L G+K+LHSAGI
Sbjct: 202 DILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260

Query: 148 IHRDLKPSNIVVKSDCTLKILDFGLART--AGTSFMMTPYVVTRYYRAPEVILGMGYKEN 205
           +HRD+KP N++V S+C LKI DFGLAR      S  MT  VVT+YYRAPE+++G  +  N
Sbjct: 261 LHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSN 320

Query: 206 -VDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRP 264
            +DIWSVGCI  E++   +LF     I Q + + + LGTP  E M+      + ++   P
Sbjct: 321 AIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGP 380

Query: 265 KYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYIN 322
                  ++    VL+   S+       +A  LL +MLV D SKRIS  +AL HPY++
Sbjct: 381 ------HKQPSLPVLYTLSSQ----ATHEAVHLLCRMLVFDPSKRISAKDALAHPYLD 428


>gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]
          Length = 544

 Score =  202 bits (514), Expect = 5e-52
 Identities = 123/355 (34%), Positives = 201/355 (56%), Gaps = 32/355 (9%)

Query: 22  VLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCV- 80
           +++RY   + +G GA GIV  A D      VAIKK+   F+++T A+R +RE+ L++   
Sbjct: 9   IVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG 68

Query: 81  NHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME--LDHERMSYLLYQMLCG 138
           +H NII LL+V   +      +D+Y+V E MD +L  VI+    L    +  + YQ+L  
Sbjct: 69  DHPNIISLLDVIRAEND----RDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRA 124

Query: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG------TSFMMTPYVVTRYYR 192
            + LHS  ++HRD KPSN+++ ++CT+K+ DFGLAR+ G          +T YV TR+YR
Sbjct: 125 TRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYR 184

Query: 193 APEVILGM-GYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKK 251
           APEV+L    Y   VD+WS+GCI+GEM++G  LFPGT  + Q   ++E +  P  E +  
Sbjct: 185 APEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLA 244

Query: 252 L----QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDAS 307
           L    + +V   + +RP+           D L P D+      + +A DLL ++LV    
Sbjct: 245 LGSGCRASVLHQLGSRPRQT--------LDALLPPDT------SPEALDLLRRLLVFAPD 290

Query: 308 KRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMD 362
           KR+S  +ALQHPY+  ++ PS+  A    +  +  +  + ++ E++  +Y+ +++
Sbjct: 291 KRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILE 345


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,634,150
Number of Sequences: 37866
Number of extensions: 752511
Number of successful extensions: 4855
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 754
Number of HSP's successfully gapped in prelim test: 65
Number of HSP's that attempted gapping in prelim test: 2622
Number of HSP's gapped (non-prelim): 1177
length of query: 427
length of database: 18,247,518
effective HSP length: 105
effective length of query: 322
effective length of database: 14,271,588
effective search space: 4595451336
effective search space used: 4595451336
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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