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Search of human proteins with 20986510
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo
sapiens]
(464 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo ... 943 0.0
gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo ... 862 0.0
gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo s... 853 0.0
gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alph... 790 0.0
gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta... 781 0.0
gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta... 733 0.0
gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha... 723 0.0
gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alph... 721 0.0
gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta... 714 0.0
gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta... 679 0.0
gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alph... 667 0.0
gi|20986508 mitogen-activated protein kinase 10 isoform 4 [Homo ... 563 e-160
gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gam... 419 e-117
gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens] 328 6e-90
gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens] 321 8e-88
gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ... 318 9e-87
gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens] 311 8e-85
gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo s... 310 1e-84
gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo ... 275 8e-74
gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo ... 267 2e-71
gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens] 264 1e-70
gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens] 264 1e-70
gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s... 263 3e-70
gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s... 256 4e-68
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s... 243 3e-64
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ... 243 3e-64
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ... 243 3e-64
gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo ... 213 2e-55
gi|149408126 nemo like kinase [Homo sapiens] 210 3e-54
gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens] 205 6e-53
>gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo
sapiens]
Length = 464
Score = 943 bits (2437), Expect = 0.0
Identities = 464/464 (100%), Positives = 464/464 (100%)
Query: 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV 60
MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV
Sbjct: 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV 60
Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120
LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH
Sbjct: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120
Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL 180
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL
Sbjct: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL 180
Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240
HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
Sbjct: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240
Query: 241 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN 300
KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN
Sbjct: 241 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN 300
Query: 301 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360
RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN
Sbjct: 301 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360
Query: 361 VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA 420
VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA
Sbjct: 361 VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA 420
Query: 421 VNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 464
VNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
Sbjct: 421 VNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 464
>gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo
sapiens]
Length = 426
Score = 862 bits (2228), Expect = 0.0
Identities = 426/426 (100%), Positives = 426/426 (100%)
Query: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98
MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP
Sbjct: 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 60
Query: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158
FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ
Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 120
Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 240
Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338
LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 300
Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398
MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV
Sbjct: 301 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 360
Query: 399 MNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAG 458
MNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAG
Sbjct: 361 MNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAG 420
Query: 459 PLGCCR 464
PLGCCR
Sbjct: 421 PLGCCR 426
>gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo
sapiens]
Length = 422
Score = 853 bits (2204), Expect = 0.0
Identities = 417/417 (100%), Positives = 417/417 (100%)
Query: 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV 60
MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV
Sbjct: 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV 60
Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120
LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH
Sbjct: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120
Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL 180
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL
Sbjct: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL 180
Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240
HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
Sbjct: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240
Query: 241 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN 300
KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN
Sbjct: 241 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN 300
Query: 301 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360
RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN
Sbjct: 301 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360
Query: 361 VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPS 417
VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPS
Sbjct: 361 VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPS 417
>gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alpha2
[Homo sapiens]
Length = 427
Score = 790 bits (2041), Expect = 0.0
Identities = 388/427 (90%), Positives = 407/427 (95%), Gaps = 1/427 (0%)
Query: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98
MS+SK DN FYSVE+GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA+L+RNVAIKKLSRP
Sbjct: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
Query: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158
FQNQTHAKRAYRELVLMKCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVIQ
Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278
MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIMGEMV HKILFPGRDYIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240
Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338
LGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHNKLKASQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398
MLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREHTIEEWKELIYKEV
Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
Query: 399 MNSEEKTKNGVVKGQPSPSGAAV-NSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASA 457
M+ EE+TKNGV++GQPSP GAAV N S+ SSSVND+SSMSTD TLASDTDSSLEA+A
Sbjct: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420
Query: 458 GPLGCCR 464
GPLGCCR
Sbjct: 421 GPLGCCR 427
>gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta2
[Homo sapiens]
Length = 427
Score = 781 bits (2018), Expect = 0.0
Identities = 383/427 (89%), Positives = 405/427 (94%), Gaps = 1/427 (0%)
Query: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98
MS+SK DN FYSVE+GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA+L+RNVAIKKLSRP
Sbjct: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
Query: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158
FQNQTHAKRAYRELVLMKCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVIQ
Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM++ +LFPG D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240
Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338
LGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHNKLKASQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398
MLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREHTIEEWKELIYKEV
Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
Query: 399 MNSEEKTKNGVVKGQPSPSGAAV-NSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASA 457
M+ EE+TKNGV++GQPSP GAAV N S+ SSSVND+SSMSTD TLASDTDSSLEA+A
Sbjct: 361 MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA 420
Query: 458 GPLGCCR 464
GPLGCCR
Sbjct: 421 GPLGCCR 427
>gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta2
[Homo sapiens]
Length = 424
Score = 733 bits (1893), Expect = 0.0
Identities = 364/426 (85%), Positives = 390/426 (91%), Gaps = 2/426 (0%)
Query: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98
MS SK D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL NVA+KKLSRP
Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
Query: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158
FQNQTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI
Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM EMV HK+LFPGRDYIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240
Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338
LGTP EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398
MLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
Query: 399 MNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAG 458
M+ EE++KNGVVK Q PS AAV+S+ + SSS+NDISSMST+QTLASDTDSSL+AS G
Sbjct: 361 MDWEERSKNGVVKDQ--PSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTG 418
Query: 459 PLGCCR 464
PL CR
Sbjct: 419 PLEGCR 424
>gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha1
[Homo sapiens]
Length = 384
Score = 723 bits (1867), Expect = 0.0
Identities = 350/378 (92%), Positives = 366/378 (96%)
Query: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98
MS+SK DN FYSVE+GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA+L+RNVAIKKLSRP
Sbjct: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
Query: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158
FQNQTHAKRAYRELVLMKCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVIQ
Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278
MMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIMGEMV HKILFPGRDYIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ 240
Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338
LGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHNKLKASQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398
MLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREHTIEEWKELIYKEV
Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
Query: 399 MNSEEKTKNGVVKGQPSP 416
M+ EE+TKNGV++GQPSP
Sbjct: 361 MDLEERTKNGVIRGQPSP 378
>gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alpha2
[Homo sapiens]
Length = 424
Score = 721 bits (1861), Expect = 0.0
Identities = 358/426 (84%), Positives = 388/426 (91%), Gaps = 2/426 (0%)
Query: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98
MS SK D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL NVA+KKLSRP
Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
Query: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158
FQNQTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI
Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE+V+ ++F G D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240
Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338
LGTP EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398
MLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
Query: 399 MNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAG 458
M+ EE++KNGVVK Q PS AAV+S+ + SSS+NDISSMST+QTLASDTDSSL+AS G
Sbjct: 361 MDWEERSKNGVVKDQ--PSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTG 418
Query: 459 PLGCCR 464
PL CR
Sbjct: 419 PLEGCR 424
>gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta1
[Homo sapiens]
Length = 384
Score = 714 bits (1844), Expect = 0.0
Identities = 345/378 (91%), Positives = 364/378 (96%)
Query: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98
MS+SK DN FYSVE+GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA+L+RNVAIKKLSRP
Sbjct: 1 MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 60
Query: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158
FQNQTHAKRAYRELVLMKCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVIQ
Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 120
Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180
Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM++ +LFPG D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ 240
Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338
LGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHNKLKASQARDLLSK
Sbjct: 241 LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK 300
Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398
MLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREHTIEEWKELIYKEV
Sbjct: 301 MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 360
Query: 399 MNSEEKTKNGVVKGQPSP 416
M+ EE+TKNGV++GQPSP
Sbjct: 361 MDLEERTKNGVIRGQPSP 378
>gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta1
[Homo sapiens]
Length = 382
Score = 679 bits (1752), Expect = 0.0
Identities = 331/377 (87%), Positives = 351/377 (93%)
Query: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98
MS SK D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL NVA+KKLSRP
Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
Query: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158
FQNQTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI
Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM EMV HK+LFPGRDYIDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQ 240
Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338
LGTP EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398
MLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
Query: 399 MNSEEKTKNGVVKGQPS 415
M+ EE++KNGVVK QPS
Sbjct: 361 MDWEERSKNGVVKDQPS 377
>gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alpha1
[Homo sapiens]
Length = 382
Score = 667 bits (1720), Expect = 0.0
Identities = 325/377 (86%), Positives = 349/377 (92%)
Query: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98
MS SK D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL NVA+KKLSRP
Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
Query: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158
FQNQTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI
Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE+V+ ++F G D+IDQWNKVIEQ
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ 240
Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338
LGTP EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +K+K SQARDLLSK
Sbjct: 241 LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK 300
Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398
MLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH IEEWKELIYKEV
Sbjct: 301 MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 360
Query: 399 MNSEEKTKNGVVKGQPS 415
M+ EE++KNGVVK QPS
Sbjct: 361 MDWEERSKNGVVKDQPS 377
>gi|20986508 mitogen-activated protein kinase 10 isoform 4 [Homo
sapiens]
Length = 277
Score = 563 bits (1450), Expect = e-160
Identities = 272/272 (100%), Positives = 272/272 (100%)
Query: 146 MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 205
MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI
Sbjct: 1 MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60
Query: 206 LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 265
LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG
Sbjct: 61 LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 120
Query: 266 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 325
RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN
Sbjct: 121 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 180
Query: 326 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 385
KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH
Sbjct: 181 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 240
Query: 386 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPS 417
TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPS
Sbjct: 241 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPS 272
>gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gamma
[Homo sapiens]
Length = 242
Score = 419 bits (1077), Expect = e-117
Identities = 207/231 (89%), Positives = 217/231 (93%)
Query: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98
MS SK D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL NVA+KKLSRP
Sbjct: 1 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP 60
Query: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158
FQNQTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI
Sbjct: 61 FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH 120
Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+F
Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF 180
Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYI 269
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE+V+ ++F G D I
Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDRI 231
>gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
Length = 364
Score = 328 bits (841), Expect = 6e-90
Identities = 171/356 (48%), Positives = 241/356 (67%), Gaps = 19/356 (5%)
Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107
FY E+ + + V +R Q L+P+GSGA G VC+AYDA L + VA+KKLSRPFQ+ HA+R
Sbjct: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67
Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERM 166
YREL L+K + H+N+I LL+VFTP ++E+F +VYLV LM A+L +++ + L E +
Sbjct: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127
Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226
+L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A MT YV T
Sbjct: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVAT 185
Query: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285
R+YRAPE++L M Y + VDIWSVGCIM E+++ K LFPG DYIDQ +++E +GTP PE
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245
Query: 286 FMKKLQPT-VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344
+ K+ R Y+++ P +F + N L A DLL +MLV+D
Sbjct: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGA--------NPL----AIDLLGRMLVLDS 293
Query: 345 AKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400
+R+S +AL H Y + ++DP + P + YD+ ++ +E T+EEWKEL Y+EV++
Sbjct: 294 DQRVSAAEALAHAYFSQYHDPE--DEPEAEPYDESVEAKERTLEEWKELTYQEVLS 347
>gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]
Length = 365
Score = 321 bits (823), Expect = 8e-88
Identities = 169/355 (47%), Positives = 231/355 (65%), Gaps = 17/355 (4%)
Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107
FY +V + + + K Y + +GSGA G VC+A D VAIKKLSRPFQ++ AKR
Sbjct: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68
Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMS 167
AYREL+L+K + H+N+I LL+VFTP +L F D YLVM M +L +++ ME E++
Sbjct: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQ 128
Query: 168 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR 227
YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A MT YVVTR
Sbjct: 129 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGYVVTR 186
Query: 228 YYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286
+YRAPEVIL M Y + VDIWSVGCIM EM+ K LF G+DY+DQ ++++ G P EF
Sbjct: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246
Query: 287 MKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345
++KL ++Y+++ P+ F +LFP + + QA DLL KML +D
Sbjct: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA------------SPQAADLLEKMLELDVD 294
Query: 346 KRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400
KR++ AL HP+ + DP E E Q +D L+ + T++EWK+ IYKE++N
Sbjct: 295 KRLTAAQALTHPFFEPFRDPEE-ETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVN 348
>gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo
sapiens]
Length = 360
Score = 318 bits (814), Expect = 9e-87
Identities = 172/356 (48%), Positives = 233/356 (65%), Gaps = 19/356 (5%)
Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107
FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ HAKR
Sbjct: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERM 166
YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV LM A+L +++ +L + +
Sbjct: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226
+L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T MT YV T
Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVAT 185
Query: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285
R+YRAPE++L M Y + VDIWSVGCIM E++ + LFPG D+IDQ ++ +GTP E
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245
Query: 286 FMKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344
+KK+ + RNY+++ + + F +F + N L A DLL KMLV+D
Sbjct: 246 LLKKISSESARNYIQSLTQMPKMNFANVFIGA--------NPL----AVDLLEKMLVLDS 293
Query: 345 AKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400
KRI+ AL H Y ++DP + P YD+ + R+ I+EWK L Y EV++
Sbjct: 294 DKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRDLLIDEWKSLTYDEVIS 347
>gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]
Length = 367
Score = 311 bits (797), Expect = 8e-85
Identities = 168/372 (45%), Positives = 240/372 (64%), Gaps = 19/372 (5%)
Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107
FY EV + + V Y++L+P+GSGA G VC+A D VAIKKL RPFQ++ AKR
Sbjct: 11 FYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR 70
Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERM 166
AYREL L+K + H+N+I LL+VFTP +TL++F D YLVM M +L ++++ E L +R+
Sbjct: 71 AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRI 130
Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226
+L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT YVVT
Sbjct: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYVVT 188
Query: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285
R+YRAPEVIL M Y + VDIWSVGCIM EM+ K LF G D++DQ ++++ GTP E
Sbjct: 189 RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAE 248
Query: 286 FMKKLQ-PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344
F+++LQ +NY++ P+ F + ++ + A +LL KMLV+D
Sbjct: 249 FVQRLQSDEAKNYMKGLPELEKKDFASILTNA------------SPLAVNLLEKMLVLDA 296
Query: 345 AKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEK 404
+R++ +AL HPY +D + P Q YD D+ + T++EWK + YKEV++ +
Sbjct: 297 EQRVTAGEALAHPYFESLHDTE--DEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPP 354
Query: 405 TKNGVVKGQPSP 416
+ G + +P
Sbjct: 355 RQLGARVSKETP 366
>gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo
sapiens]
Length = 360
Score = 310 bits (795), Expect = 1e-84
Identities = 170/357 (47%), Positives = 232/357 (64%), Gaps = 21/357 (5%)
Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107
FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ HAKR
Sbjct: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERM 166
YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV LM A+L +++ +L + +
Sbjct: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226
+L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T MT YV T
Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVAT 185
Query: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285
R+YRAPE++L M Y + VDIWSVGCIM E++ + LFPG D+I+Q +++ GTP P
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTP-PA 244
Query: 286 FMKKLQPT--VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVID 343
++ P+ RNY+++ + + F +F + N L A DLL KMLV+D
Sbjct: 245 YLINRMPSHEARNYIQSLTQMPKMNFANVFIGA--------NPL----AVDLLEKMLVLD 292
Query: 344 PAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400
KRI+ AL H Y ++DP + P YD+ + R+ I+EWK L Y EV++
Sbjct: 293 SDKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRDLLIDEWKSLTYDEVIS 347
>gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo
sapiens]
Length = 297
Score = 275 bits (702), Expect = 8e-74
Identities = 140/269 (52%), Positives = 189/269 (70%), Gaps = 5/269 (1%)
Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107
FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ HAKR
Sbjct: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERM 166
YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV LM A+L +++ +L + +
Sbjct: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226
+L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T MT YV T
Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVAT 185
Query: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285
R+YRAPE++L M Y + VDIWSVGCIM E++ + LFPG D+IDQ ++ +GTP E
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245
Query: 286 FMKKL-QPTVRNYVENRPKYAGLTFPKLF 313
+KK+ + RNY+++ + + F +F
Sbjct: 246 LLKKISSESARNYIQSLTQMPKMNFANVF 274
>gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo
sapiens]
Length = 307
Score = 267 bits (682), Expect = 2e-71
Identities = 135/245 (55%), Positives = 177/245 (72%), Gaps = 4/245 (1%)
Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107
FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ HAKR
Sbjct: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERM 166
YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV LM A+L +++ +L + +
Sbjct: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226
+L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T MT YV T
Sbjct: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVAT 185
Query: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285
R+YRAPE++L M Y + VDIWSVGCIM E++ + LFPG D+IDQ ++ +GTP E
Sbjct: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245
Query: 286 FMKKL 290
+KK+
Sbjct: 246 LLKKI 250
>gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 264 bits (674), Expect = 1e-70
Identities = 148/353 (41%), Positives = 225/353 (63%), Gaps = 24/353 (6%)
Query: 53 VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL 112
V F V RY NL IG GA G+VC+AYD V VAIKK+S PF++QT+ +R RE+
Sbjct: 14 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREI 72
Query: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLY 171
++ H+NII + ++ T+E+ +DVY+V +LM+ +L ++++ + L ++ + Y LY
Sbjct: 73 KILLRFRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 131
Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTR 227
Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR
Sbjct: 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 191
Query: 228 YYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286
+YRAPE++L GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E
Sbjct: 192 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251
Query: 287 MK-KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345
+ + RNY+ + P + + +LFP++ S+A DLL KML +P
Sbjct: 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPNA------------DSKALDLLDKMLTFNPH 299
Query: 346 KRISVDDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKE 397
KRI V+ AL HPY+ +YDP+ E A P +D +LD+ E+ KELI++E
Sbjct: 300 KRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350
>gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 264 bits (674), Expect = 1e-70
Identities = 148/353 (41%), Positives = 225/353 (63%), Gaps = 24/353 (6%)
Query: 53 VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL 112
V F V RY NL IG GA G+VC+AYD V VAIKK+S PF++QT+ +R RE+
Sbjct: 14 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREI 72
Query: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLY 171
++ H+NII + ++ T+E+ +DVY+V +LM+ +L ++++ + L ++ + Y LY
Sbjct: 73 KILLRFRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 131
Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTR 227
Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR
Sbjct: 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 191
Query: 228 YYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286
+YRAPE++L GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E
Sbjct: 192 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251
Query: 287 MK-KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345
+ + RNY+ + P + + +LFP++ S+A DLL KML +P
Sbjct: 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPNA------------DSKALDLLDKMLTFNPH 299
Query: 346 KRISVDDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKE 397
KRI V+ AL HPY+ +YDP+ E A P +D +LD+ E+ KELI++E
Sbjct: 300 KRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350
>gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo
sapiens]
Length = 379
Score = 263 bits (671), Expect = 3e-70
Identities = 145/348 (41%), Positives = 221/348 (63%), Gaps = 24/348 (6%)
Query: 58 FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC 117
F V RY L+ IG GA G+V +AYD V VAIKK+S PF++QT+ +R RE+ ++
Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94
Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 176
H+N+I + ++ TLE +DVY+V +LM+ +L ++++ +L ++ + Y LYQ+L G
Sbjct: 95 FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 232
+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP
Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
Query: 233 EVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK-KL 290
E++L GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E + +
Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273
Query: 291 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350
RNY+++ P + + KLFP S S+A DLL +ML +P KRI+V
Sbjct: 274 NMKARNYLQSLPSKTKVAWAKLFPKS------------DSKALDLLDRMLTFNPNKRITV 321
Query: 351 DDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKE 397
++AL HPY+ +YDP E A P + +LD+ E KELI++E
Sbjct: 322 EEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 367
>gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo
sapiens]
Length = 357
Score = 256 bits (653), Expect = 4e-68
Identities = 135/323 (41%), Positives = 207/323 (64%), Gaps = 21/323 (6%)
Query: 58 FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC 117
F V RY L+ IG GA G+V +AYD V VAIKK+S PF++QT+ +R RE+ ++
Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94
Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 176
H+N+I + ++ TLE +DVY+V +LM+ +L ++++ +L ++ + Y LYQ+L G
Sbjct: 95 FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 232
+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP
Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
Query: 233 EVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK-KL 290
E++L GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E + +
Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273
Query: 291 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350
RNY+++ P + + KLFP S S+A DLL +ML +P KRI+V
Sbjct: 274 NMKARNYLQSLPSKTKVAWAKLFPKS------------DSKALDLLDRMLTFNPNKRITV 321
Query: 351 DDALQHPYINVWYDPAEVEAPPP 373
++AL HPY+ +YDP + P
Sbjct: 322 EEALAHPYLEQYYDPTDEVGQSP 344
>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 243 bits (620), Expect = 3e-64
Identities = 144/374 (38%), Positives = 221/374 (59%), Gaps = 28/374 (7%)
Query: 55 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL 114
D TF V Y+ ++ IG+GA G+V +A + + VAIKK+ F T+AKR REL +
Sbjct: 46 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105
Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELDHERMSYLLYQ 172
+K H NII++ ++ P EF+ VY+V++LM+++L Q+I L E + Y LYQ
Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165
Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS-----FMMTPYVVTR 227
+L G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR TS + MT YV TR
Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225
Query: 228 YYRAPEVILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286
+YRAPE++L + Y + +D+WSVGCI GEM+ + LFPG++Y+ Q ++ LGTP P
Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285
Query: 287 MKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345
++ + VR Y+++ P + + ++P + QA LL +ML +P+
Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPGA------------DRQALSLLGRMLRFEPS 333
Query: 346 KRISVDDALQHPYINVWYDP-AEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEK 404
RIS AL+HP++ ++DP E + PP +D D T E KE I E+ + +
Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPP--FDFAFDREALTRERIKEAIVAEIEDFHAR 391
Query: 405 TKNGV---VKGQPS 415
+ G+ ++ QPS
Sbjct: 392 -REGIRQQIRFQPS 404
>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 243 bits (620), Expect = 3e-64
Identities = 144/374 (38%), Positives = 221/374 (59%), Gaps = 28/374 (7%)
Query: 55 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL 114
D TF V Y+ ++ IG+GA G+V +A + + VAIKK+ F T+AKR REL +
Sbjct: 46 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105
Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELDHERMSYLLYQ 172
+K H NII++ ++ P EF+ VY+V++LM+++L Q+I L E + Y LYQ
Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165
Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS-----FMMTPYVVTR 227
+L G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR TS + MT YV TR
Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225
Query: 228 YYRAPEVILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286
+YRAPE++L + Y + +D+WSVGCI GEM+ + LFPG++Y+ Q ++ LGTP P
Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285
Query: 287 MKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345
++ + VR Y+++ P + + ++P + QA LL +ML +P+
Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPGA------------DRQALSLLGRMLRFEPS 333
Query: 346 KRISVDDALQHPYINVWYDP-AEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEK 404
RIS AL+HP++ ++DP E + PP +D D T E KE I E+ + +
Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPP--FDFAFDREALTRERIKEAIVAEIEDFHAR 391
Query: 405 TKNGV---VKGQPS 415
+ G+ ++ QPS
Sbjct: 392 -REGIRQQIRFQPS 404
>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 243 bits (620), Expect = 3e-64
Identities = 144/374 (38%), Positives = 221/374 (59%), Gaps = 28/374 (7%)
Query: 55 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL 114
D TF V Y+ ++ IG+GA G+V +A + + VAIKK+ F T+AKR REL +
Sbjct: 46 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 105
Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELDHERMSYLLYQ 172
+K H NII++ ++ P EF+ VY+V++LM+++L Q+I L E + Y LYQ
Sbjct: 106 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165
Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS-----FMMTPYVVTR 227
+L G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR TS + MT YV TR
Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 225
Query: 228 YYRAPEVILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286
+YRAPE++L + Y + +D+WSVGCI GEM+ + LFPG++Y+ Q ++ LGTP P
Sbjct: 226 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 285
Query: 287 MKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345
++ + VR Y+++ P + + ++P + QA LL +ML +P+
Sbjct: 286 IQAVGAERVRAYIQSLPPRQPVPWETVYPGA------------DRQALSLLGRMLRFEPS 333
Query: 346 KRISVDDALQHPYINVWYDP-AEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEK 404
RIS AL+HP++ ++DP E + PP +D D T E KE I E+ + +
Sbjct: 334 ARISAAAALRHPFLAKYHDPDDEPDCAPP--FDFAFDREALTRERIKEAIVAEIEDFHAR 391
Query: 405 TKNGV---VKGQPS 415
+ G+ ++ QPS
Sbjct: 392 -REGIRQQIRFQPS 404
>gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo
sapiens]
Length = 335
Score = 213 bits (543), Expect = 2e-55
Identities = 130/347 (37%), Positives = 193/347 (55%), Gaps = 66/347 (19%)
Query: 58 FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC 117
F V RY L+ IG GA G+V +AYD V VAIKK+S PF++QT+ +R RE+ ++
Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94
Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 176
H+N+I + ++ TLE +DVY+V +LM+ +L ++++ +L ++ + Y LYQ+L G
Sbjct: 95 FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 232
+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP
Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
Query: 233 EVILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ 291
E++L GY +++DIWSVGCI+ EM+
Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEML---------------------------------- 239
Query: 292 PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVD 351
NRP +FP ++L A DLL +ML +P KRI+V+
Sbjct: 240 -------SNRP--------------IFPGKHYLDQLNHILALDLLDRMLTFNPNKRITVE 278
Query: 352 DALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKE 397
+AL HPY+ +YDP E A P + +LD+ E KELI++E
Sbjct: 279 EALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 323
>gi|149408126 nemo like kinase [Homo sapiens]
Length = 527
Score = 210 bits (534), Expect = 3e-54
Identities = 121/298 (40%), Positives = 181/298 (60%), Gaps = 16/298 (5%)
Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLL 127
+PIG GA G+V + D + VA+KK+ FQN KR +REL ++ H N++S L
Sbjct: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201
Query: 128 NVFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELDHERMSYLLYQMLCGIKHLHSAGI 185
++ P ++ F+++Y+V ELM ++L ++I L + + LYQ+L G+K+LHSAGI
Sbjct: 202 DILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260
Query: 186 IHRDLKPSNIVVKSDCTLKILDFGLART--AGTSFMMTPYVVTRYYRAPEVILGMGYKEN 243
+HRD+KP N++V S+C LKI DFGLAR S MT VVT+YYRAPE+++G + N
Sbjct: 261 LHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSN 320
Query: 244 -VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRP 302
+DIWSVGCI E++ +ILF + I Q + + + LGTP E M+ + ++ P
Sbjct: 321 AIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGP 380
Query: 303 KYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360
+ + P L+ S + + H +A LL +MLV DP+KRIS DAL HPY++
Sbjct: 381 -HKQPSLPVLYTLS---SQATH------EAVHLLCRMLVFDPSKRISAKDALAHPYLD 428
>gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]
Length = 544
Score = 205 bits (522), Expect = 6e-53
Identities = 135/390 (34%), Positives = 215/390 (55%), Gaps = 44/390 (11%)
Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV- 118
+++RY + +G GA GIV A D VAIKK+ F+++T A+R +RE+ L++
Sbjct: 9 IVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG 68
Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME--LDHERMSYLLYQMLCG 176
+H NIISLL+V E +D+YLV E MD +L VI+ L + + YQ+L
Sbjct: 69 DHPNIISLLDVIRA----ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRA 124
Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG------TSFMMTPYVVTRYYR 230
+ LHS ++HRD KPSN+++ ++CT+K+ DFGLAR+ G +T YV TR+YR
Sbjct: 125 TRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYR 184
Query: 231 APEVILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 289
APEV+L Y VD+WS+GCI+GEM+R + LFPG + Q ++E + P E +
Sbjct: 185 APEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLA 244
Query: 290 L----QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345
L + +V + + +RP+ D+L P D+ + +A DLL ++LV P
Sbjct: 245 LGSGCRASVLHQLGSRPRQT--------LDALLPPDT------SPEALDLLRRLLVFAPD 290
Query: 346 KRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVM------ 399
KR+S ALQHPY+ ++ P++ A + + + + ++ E++ +Y+ ++
Sbjct: 291 KRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILECGGSS 350
Query: 400 -NSEEKTKNGVVKGQPSPSGAAVNSSESLP 428
S EK GV SPS A ++ + P
Sbjct: 351 GTSREKGPEGV-----SPSQAHLHKPRADP 375
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,970,346
Number of Sequences: 37866
Number of extensions: 798568
Number of successful extensions: 5051
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 753
Number of HSP's successfully gapped in prelim test: 55
Number of HSP's that attempted gapping in prelim test: 2794
Number of HSP's gapped (non-prelim): 1190
length of query: 464
length of database: 18,247,518
effective HSP length: 106
effective length of query: 358
effective length of database: 14,233,722
effective search space: 5095672476
effective search space used: 5095672476
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.