Search of human proteins with 20986508

Search of human proteins with 20986508

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|20986508 mitogen-activated protein kinase 10 isoform 4 [Homo
sapiens]
         (277 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo s...   572   e-163
gi|20986508 mitogen-activated protein kinase 10 isoform 4 [Homo ...   572   e-163
gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo ...   563   e-161
gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo ...   563   e-161
gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha...   533   e-152
gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alph...   525   e-149
gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta...   525   e-149
gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta...   516   e-147
gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta...   494   e-140
gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta...   493   e-140
gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alph...   482   e-136
gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alph...   481   e-136
gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gam...   231   4e-61
gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]         226   1e-59
gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]        219   2e-57
gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]        209   2e-54
gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ...   203   2e-52
gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s...   198   5e-51
gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo s...   196   2e-50
gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]         194   7e-50
gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]         194   7e-50
gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s...   191   6e-49
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s...   179   2e-45
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ...   179   2e-45
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ...   179   2e-45
gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo s...   176   2e-44
gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo ...   160   1e-39
gi|149408126 nemo like kinase [Homo sapiens]                          157   7e-39
gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo ...   152   3e-37
gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]        152   3e-37

>gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo
           sapiens]
          Length = 422

 Score =  572 bits (1473), Expect = e-163
 Identities = 277/277 (100%), Positives = 277/277 (100%)

Query: 1   MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60
           MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI
Sbjct: 146 MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 205

Query: 61  LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 120
           LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG
Sbjct: 206 LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 265

Query: 121 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 180
           RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN
Sbjct: 266 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 325

Query: 181 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 240
           KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH
Sbjct: 326 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 385

Query: 241 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSAQVQQ 277
           TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSAQVQQ
Sbjct: 386 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSAQVQQ 422


>gi|20986508 mitogen-activated protein kinase 10 isoform 4 [Homo
           sapiens]
          Length = 277

 Score =  572 bits (1473), Expect = e-163
 Identities = 277/277 (100%), Positives = 277/277 (100%)

Query: 1   MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60
           MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI
Sbjct: 1   MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60

Query: 61  LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 120
           LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG
Sbjct: 61  LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 120

Query: 121 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 180
           RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN
Sbjct: 121 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 180

Query: 181 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 240
           KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH
Sbjct: 181 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 240

Query: 241 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSAQVQQ 277
           TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSAQVQQ
Sbjct: 241 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSAQVQQ 277


>gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo
           sapiens]
          Length = 464

 Score =  563 bits (1450), Expect = e-161
 Identities = 272/272 (100%), Positives = 272/272 (100%)

Query: 1   MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60
           MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI
Sbjct: 146 MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 205

Query: 61  LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 120
           LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG
Sbjct: 206 LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 265

Query: 121 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 180
           RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN
Sbjct: 266 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 325

Query: 181 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 240
           KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH
Sbjct: 326 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 385

Query: 241 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPS 272
           TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPS
Sbjct: 386 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPS 417


>gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo
           sapiens]
          Length = 426

 Score =  563 bits (1450), Expect = e-161
 Identities = 272/272 (100%), Positives = 272/272 (100%)

Query: 1   MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60
           MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI
Sbjct: 108 MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 167

Query: 61  LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 120
           LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG
Sbjct: 168 LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 227

Query: 121 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 180
           RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN
Sbjct: 228 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 287

Query: 181 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 240
           KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH
Sbjct: 288 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 347

Query: 241 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPS 272
           TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPS
Sbjct: 348 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPS 379


>gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha1
           [Homo sapiens]
          Length = 384

 Score =  533 bits (1374), Expect = e-152
 Identities = 257/277 (92%), Positives = 267/277 (96%)

Query: 1   MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60
           MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI
Sbjct: 108 MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 167

Query: 61  LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 120
           LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIMGEMV HKILFPG
Sbjct: 168 LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPG 227

Query: 121 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 180
           RDYIDQWNKVIEQLGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHN
Sbjct: 228 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHN 287

Query: 181 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 240
           KLKASQARDLLSKMLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREH
Sbjct: 288 KLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREH 347

Query: 241 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSAQVQQ 277
           TIEEWKELIYKEVM+ EE+TKNGV++GQPSP AQVQQ
Sbjct: 348 TIEEWKELIYKEVMDLEERTKNGVIRGQPSPLAQVQQ 384


>gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alpha2
           [Homo sapiens]
          Length = 427

 Score =  525 bits (1353), Expect = e-149
 Identities = 252/271 (92%), Positives = 262/271 (96%)

Query: 1   MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60
           MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI
Sbjct: 108 MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 167

Query: 61  LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 120
           LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVD+WSVGCIMGEMV HKILFPG
Sbjct: 168 LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPG 227

Query: 121 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 180
           RDYIDQWNKVIEQLGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHN
Sbjct: 228 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHN 287

Query: 181 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 240
           KLKASQARDLLSKMLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREH
Sbjct: 288 KLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREH 347

Query: 241 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSP 271
           TIEEWKELIYKEVM+ EE+TKNGV++GQPSP
Sbjct: 348 TIEEWKELIYKEVMDLEERTKNGVIRGQPSP 378


>gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta1
           [Homo sapiens]
          Length = 384

 Score =  525 bits (1351), Expect = e-149
 Identities = 252/277 (90%), Positives = 265/277 (95%)

Query: 1   MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60
           MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI
Sbjct: 108 MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 167

Query: 61  LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 120
           LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM++  +LFPG
Sbjct: 168 LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPG 227

Query: 121 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 180
            D+IDQWNKVIEQLGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHN
Sbjct: 228 TDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHN 287

Query: 181 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 240
           KLKASQARDLLSKMLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREH
Sbjct: 288 KLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREH 347

Query: 241 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSAQVQQ 277
           TIEEWKELIYKEVM+ EE+TKNGV++GQPSP AQVQQ
Sbjct: 348 TIEEWKELIYKEVMDLEERTKNGVIRGQPSPLAQVQQ 384


>gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta2
           [Homo sapiens]
          Length = 427

 Score =  516 bits (1330), Expect = e-147
 Identities = 247/271 (91%), Positives = 260/271 (95%)

Query: 1   MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60
           MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI
Sbjct: 108 MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 167

Query: 61  LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 120
           LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM++  +LFPG
Sbjct: 168 LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPG 227

Query: 121 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 180
            D+IDQWNKVIEQLGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHN
Sbjct: 228 TDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHN 287

Query: 181 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 240
           KLKASQARDLLSKMLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREH
Sbjct: 288 KLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREH 347

Query: 241 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSP 271
           TIEEWKELIYKEVM+ EE+TKNGV++GQPSP
Sbjct: 348 TIEEWKELIYKEVMDLEERTKNGVIRGQPSP 378


>gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta1
           [Homo sapiens]
          Length = 382

 Score =  494 bits (1272), Expect = e-140
 Identities = 240/277 (86%), Positives = 256/277 (92%), Gaps = 2/277 (0%)

Query: 1   MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60
           MELMDANLCQVI MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI
Sbjct: 108 MELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 167

Query: 61  LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 120
           LDFGLARTA T+FMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM EMV HK+LFPG
Sbjct: 168 LDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPG 227

Query: 121 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 180
           RDYIDQWNKVIEQLGTP  EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +
Sbjct: 228 RDYIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERD 287

Query: 181 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 240
           K+K SQARDLLSKMLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH
Sbjct: 288 KIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREH 347

Query: 241 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSAQVQQ 277
            IEEWKELIYKEVM+ EE++KNGVVK Q  PSAQ+QQ
Sbjct: 348 AIEEWKELIYKEVMDWEERSKNGVVKDQ--PSAQMQQ 382


>gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta2
           [Homo sapiens]
          Length = 424

 Score =  493 bits (1269), Expect = e-140
 Identities = 237/273 (86%), Positives = 253/273 (92%)

Query: 1   MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60
           MELMDANLCQVI MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI
Sbjct: 108 MELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 167

Query: 61  LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 120
           LDFGLARTA T+FMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM EMV HK+LFPG
Sbjct: 168 LDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPG 227

Query: 121 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 180
           RDYIDQWNKVIEQLGTP  EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +
Sbjct: 228 RDYIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERD 287

Query: 181 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 240
           K+K SQARDLLSKMLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH
Sbjct: 288 KIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREH 347

Query: 241 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSA 273
            IEEWKELIYKEVM+ EE++KNGVVK QPS +A
Sbjct: 348 AIEEWKELIYKEVMDWEERSKNGVVKDQPSDAA 380


>gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alpha1
           [Homo sapiens]
          Length = 382

 Score =  482 bits (1240), Expect = e-136
 Identities = 234/277 (84%), Positives = 254/277 (91%), Gaps = 2/277 (0%)

Query: 1   MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60
           MELMDANLCQVI MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI
Sbjct: 108 MELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 167

Query: 61  LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 120
           LDFGLARTA T+FMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE+V+  ++F G
Sbjct: 168 LDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQG 227

Query: 121 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 180
            D+IDQWNKVIEQLGTP  EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +
Sbjct: 228 TDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERD 287

Query: 181 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 240
           K+K SQARDLLSKMLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH
Sbjct: 288 KIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREH 347

Query: 241 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSAQVQQ 277
            IEEWKELIYKEVM+ EE++KNGVVK Q  PSAQ+QQ
Sbjct: 348 AIEEWKELIYKEVMDWEERSKNGVVKDQ--PSAQMQQ 382


>gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alpha2
           [Homo sapiens]
          Length = 424

 Score =  481 bits (1237), Expect = e-136
 Identities = 231/273 (84%), Positives = 251/273 (91%)

Query: 1   MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60
           MELMDANLCQVI MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI
Sbjct: 108 MELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 167

Query: 61  LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 120
           LDFGLARTA T+FMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE+V+  ++F G
Sbjct: 168 LDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQG 227

Query: 121 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN 180
            D+IDQWNKVIEQLGTP  EFMKKLQPTVRNYVENRPKY G+ F +LFPD +FP++SE +
Sbjct: 228 TDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERD 287

Query: 181 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREH 240
           K+K SQARDLLSKMLVIDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH
Sbjct: 288 KIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREH 347

Query: 241 TIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSA 273
            IEEWKELIYKEVM+ EE++KNGVVK QPS +A
Sbjct: 348 AIEEWKELIYKEVMDWEERSKNGVVKDQPSDAA 380


>gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gamma
           [Homo sapiens]
          Length = 242

 Score =  231 bits (590), Expect = 4e-61
 Identities = 112/124 (90%), Positives = 117/124 (94%)

Query: 1   MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60
           MELMDANLCQVI MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI
Sbjct: 108 MELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 167

Query: 61  LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 120
           LDFGLARTA T+FMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE+V+  ++F G
Sbjct: 168 LDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQG 227

Query: 121 RDYI 124
            D I
Sbjct: 228 TDRI 231


>gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]
          Length = 365

 Score =  226 bits (577), Expect = 1e-59
 Identities = 119/257 (46%), Positives = 165/257 (64%), Gaps = 17/257 (6%)

Query: 1   MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60
           M  M  +L +++ ME   E++ YL+YQML G+K++HSAG++HRDLKP N+ V  DC LKI
Sbjct: 107 MPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKI 166

Query: 61  LDFGLARTAGTSFMMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFP 119
           LDFGLAR A     MT YVVTR+YRAPEVIL  M Y + VDIWSVGCIM EM+  K LF 
Sbjct: 167 LDFGLARHADAE--MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFK 224

Query: 120 GRDYIDQWNKVIEQLGTPCPEFMKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSE 178
           G+DY+DQ  ++++  G P  EF++KL     ++Y+++ P+     F +LFP +       
Sbjct: 225 GKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA------- 277

Query: 179 HNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDER 238
                + QA DLL KML +D  KR++   AL HP+   + DP E E    Q +D  L+  
Sbjct: 278 -----SPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEE-ETEAQQPFDDSLEHE 331

Query: 239 EHTIEEWKELIYKEVMN 255
           + T++EWK+ IYKE++N
Sbjct: 332 KLTVDEWKQHIYKEIVN 348


>gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
          Length = 364

 Score =  219 bits (558), Expect = 2e-57
 Identities = 117/256 (45%), Positives = 167/256 (65%), Gaps = 19/256 (7%)

Query: 3   LMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKIL 61
           LM A+L  +++ + L  E + +L+YQ+L G+K++HSAGIIHRDLKPSN+ V  DC L+IL
Sbjct: 108 LMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRIL 167

Query: 62  DFGLARTAGTSFMMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPG 120
           DFGLAR A     MT YV TR+YRAPE++L  M Y + VDIWSVGCIM E+++ K LFPG
Sbjct: 168 DFGLARQADEE--MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPG 225

Query: 121 RDYIDQWNKVIEQLGTPCPEFMKKLQPT-VRNYVENRPKYAGLTFPKLFPDSLFPADSEH 179
            DYIDQ  +++E +GTP PE + K+     R Y+++ P         +F  +        
Sbjct: 226 SDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGA-------- 277

Query: 180 NKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDERE 239
           N L    A DLL +MLV+D  +R+S  +AL H Y + ++DP   + P  + YD+ ++ +E
Sbjct: 278 NPL----AIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPE--DEPEAEPYDESVEAKE 331

Query: 240 HTIEEWKELIYKEVMN 255
            T+EEWKEL Y+EV++
Sbjct: 332 RTLEEWKELTYQEVLS 347


>gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]
          Length = 367

 Score =  209 bits (532), Expect = 2e-54
 Identities = 115/274 (41%), Positives = 170/274 (62%), Gaps = 19/274 (6%)

Query: 1   MELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLK 59
           M  M  +L ++++ E L  +R+ +L+YQML G++++H+AGIIHRDLKP N+ V  DC LK
Sbjct: 109 MPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELK 168

Query: 60  ILDFGLARTAGTSFMMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILF 118
           ILDFGLAR A +   MT YVVTR+YRAPEVIL  M Y + VDIWSVGCIM EM+  K LF
Sbjct: 169 ILDFGLARQADSE--MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLF 226

Query: 119 PGRDYIDQWNKVIEQLGTPCPEFMKKLQ-PTVRNYVENRPKYAGLTFPKLFPDSLFPADS 177
            G D++DQ  ++++  GTP  EF+++LQ    +NY++  P+     F  +  ++      
Sbjct: 227 KGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNA------ 280

Query: 178 EHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDE 237
                 +  A +LL KMLV+D  +R++  +AL HPY    +D    + P  Q YD   D+
Sbjct: 281 ------SPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTE--DEPQVQKYDDSFDD 332

Query: 238 REHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSP 271
            + T++EWK + YKEV++ +   + G    + +P
Sbjct: 333 VDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETP 366


>gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo
           sapiens]
          Length = 360

 Score =  203 bits (516), Expect = 2e-52
 Identities = 114/256 (44%), Positives = 160/256 (62%), Gaps = 19/256 (7%)

Query: 3   LMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKIL 61
           LM A+L  +++ + L  + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKIL
Sbjct: 108 LMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKIL 167

Query: 62  DFGLARTAGTSFMMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPG 120
           DFGLAR   T   MT YV TR+YRAPE++L  M Y + VDIWSVGCIM E++  + LFPG
Sbjct: 168 DFGLAR--HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPG 225

Query: 121 RDYIDQWNKVIEQLGTPCPEFMKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEH 179
            D+IDQ   ++  +GTP  E +KK+   + RNY+++  +   + F  +F  +        
Sbjct: 226 TDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGA-------- 277

Query: 180 NKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDERE 239
           N L    A DLL KMLV+D  KRI+   AL H Y   ++DP +     P  YD+  + R+
Sbjct: 278 NPL----AVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRD 331

Query: 240 HTIEEWKELIYKEVMN 255
             I+EWK L Y EV++
Sbjct: 332 LLIDEWKSLTYDEVIS 347


>gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo
           sapiens]
          Length = 379

 Score =  198 bits (503), Expect = 5e-51
 Identities = 107/259 (41%), Positives = 165/259 (63%), Gaps = 22/259 (8%)

Query: 2   ELMDANLCQVIQ-MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60
           +LM+ +L ++++  +L ++ + Y LYQ+L G+K++HSA ++HRDLKPSN+++ + C LKI
Sbjct: 123 DLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKI 182

Query: 61  LDFGLARTAGTSF----MMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHK 115
            DFGLAR A         +T YV TR+YRAPE++L   GY +++DIWSVGCI+ EM+ ++
Sbjct: 183 CDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR 242

Query: 116 ILFPGRDYIDQWNKVIEQLGTPCPEFMK-KLQPTVRNYVENRPKYAGLTFPKLFPDSLFP 174
            +FPG+ Y+DQ N ++  LG+P  E +   +    RNY+++ P    + + KLFP S   
Sbjct: 243 PIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKS--- 299

Query: 175 ADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPA-EVEAPPPQIYDK 233
                     S+A DLL +ML  +P KRI+V++AL HPY+  +YDP  E  A  P  +  
Sbjct: 300 ---------DSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAM 350

Query: 234 QLDEREHTIEEWKELIYKE 252
           +LD+     E  KELI++E
Sbjct: 351 ELDDLPK--ERLKELIFQE 367


>gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo
           sapiens]
          Length = 360

 Score =  196 bits (497), Expect = 2e-50
 Identities = 112/257 (43%), Positives = 159/257 (61%), Gaps = 21/257 (8%)

Query: 3   LMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKIL 61
           LM A+L  +++ + L  + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKIL
Sbjct: 108 LMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKIL 167

Query: 62  DFGLARTAGTSFMMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPG 120
           DFGLAR   T   MT YV TR+YRAPE++L  M Y + VDIWSVGCIM E++  + LFPG
Sbjct: 168 DFGLAR--HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPG 225

Query: 121 RDYIDQWNKVIEQLGTPCPEFMKKLQPT--VRNYVENRPKYAGLTFPKLFPDSLFPADSE 178
            D+I+Q  +++   GTP P ++    P+   RNY+++  +   + F  +F  +       
Sbjct: 226 TDHINQLQQIMRLTGTP-PAYLINRMPSHEARNYIQSLTQMPKMNFANVFIGA------- 277

Query: 179 HNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDER 238
            N L    A DLL KMLV+D  KRI+   AL H Y   ++DP +     P  YD+  + R
Sbjct: 278 -NPL----AVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESR 330

Query: 239 EHTIEEWKELIYKEVMN 255
           +  I+EWK L Y EV++
Sbjct: 331 DLLIDEWKSLTYDEVIS 347


>gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]
          Length = 360

 Score =  194 bits (493), Expect = 7e-50
 Identities = 107/259 (41%), Positives = 166/259 (64%), Gaps = 22/259 (8%)

Query: 2   ELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60
           +LM+ +L ++++ + L ++ + Y LYQ+L G+K++HSA ++HRDLKPSN+++ + C LKI
Sbjct: 106 DLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKI 165

Query: 61  LDFGLARTAGTSF----MMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHK 115
            DFGLAR A         +T YV TR+YRAPE++L   GY +++DIWSVGCI+ EM+ ++
Sbjct: 166 CDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR 225

Query: 116 ILFPGRDYIDQWNKVIEQLGTPCPEFMK-KLQPTVRNYVENRPKYAGLTFPKLFPDSLFP 174
            +FPG+ Y+DQ N ++  LG+P  E +   +    RNY+ + P    + + +LFP++   
Sbjct: 226 PIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNA--- 282

Query: 175 ADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPA-EVEAPPPQIYDK 233
                     S+A DLL KML  +P KRI V+ AL HPY+  +YDP+ E  A  P  +D 
Sbjct: 283 ---------DSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDM 333

Query: 234 QLDEREHTIEEWKELIYKE 252
           +LD+     E+ KELI++E
Sbjct: 334 ELDDLPK--EKLKELIFEE 350


>gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]
          Length = 360

 Score =  194 bits (493), Expect = 7e-50
 Identities = 107/259 (41%), Positives = 166/259 (64%), Gaps = 22/259 (8%)

Query: 2   ELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60
           +LM+ +L ++++ + L ++ + Y LYQ+L G+K++HSA ++HRDLKPSN+++ + C LKI
Sbjct: 106 DLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKI 165

Query: 61  LDFGLARTAGTSF----MMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHK 115
            DFGLAR A         +T YV TR+YRAPE++L   GY +++DIWSVGCI+ EM+ ++
Sbjct: 166 CDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR 225

Query: 116 ILFPGRDYIDQWNKVIEQLGTPCPEFMK-KLQPTVRNYVENRPKYAGLTFPKLFPDSLFP 174
            +FPG+ Y+DQ N ++  LG+P  E +   +    RNY+ + P    + + +LFP++   
Sbjct: 226 PIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNA--- 282

Query: 175 ADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPA-EVEAPPPQIYDK 233
                     S+A DLL KML  +P KRI V+ AL HPY+  +YDP+ E  A  P  +D 
Sbjct: 283 ---------DSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDM 333

Query: 234 QLDEREHTIEEWKELIYKE 252
           +LD+     E+ KELI++E
Sbjct: 334 ELDDLPK--EKLKELIFEE 350


>gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo
           sapiens]
          Length = 357

 Score =  191 bits (485), Expect = 6e-49
 Identities = 97/234 (41%), Positives = 151/234 (64%), Gaps = 19/234 (8%)

Query: 2   ELMDANLCQVIQ-MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60
           +LM+ +L ++++  +L ++ + Y LYQ+L G+K++HSA ++HRDLKPSN+++ + C LKI
Sbjct: 123 DLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKI 182

Query: 61  LDFGLARTAGTSF----MMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHK 115
            DFGLAR A         +T YV TR+YRAPE++L   GY +++DIWSVGCI+ EM+ ++
Sbjct: 183 CDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR 242

Query: 116 ILFPGRDYIDQWNKVIEQLGTPCPEFMK-KLQPTVRNYVENRPKYAGLTFPKLFPDSLFP 174
            +FPG+ Y+DQ N ++  LG+P  E +   +    RNY+++ P    + + KLFP S   
Sbjct: 243 PIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKS--- 299

Query: 175 ADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPP 228
                     S+A DLL +ML  +P KRI+V++AL HPY+  +YDP +     P
Sbjct: 300 ---------DSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEVGQSP 344


>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
           sapiens]
          Length = 816

 Score =  179 bits (455), Expect = 2e-45
 Identities = 108/283 (38%), Positives = 167/283 (59%), Gaps = 28/283 (9%)

Query: 1   MELMDANLCQVIQME--LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL 58
           ++LM+++L Q+I     L  E + Y LYQ+L G+K++HSA +IHRDLKPSN++V  +C L
Sbjct: 137 LDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCEL 196

Query: 59  KILDFGLARTAGTS-----FMMTPYVVTRYYRAPEVILGM-GYKENVDIWSVGCIMGEMV 112
           KI DFG+AR   TS     + MT YV TR+YRAPE++L +  Y + +D+WSVGCI GEM+
Sbjct: 197 KIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEML 256

Query: 113 RHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL-QPTVRNYVENRPKYAGLTFPKLFPDS 171
             + LFPG++Y+ Q   ++  LGTP P  ++ +    VR Y+++ P    + +  ++P +
Sbjct: 257 ARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGA 316

Query: 172 LFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDP-AEVEAPPPQI 230
                         QA  LL +ML  +P+ RIS   AL+HP++  ++DP  E +  PP  
Sbjct: 317 ------------DRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPP-- 362

Query: 231 YDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGV---VKGQPS 270
           +D   D    T E  KE I  E+ +   + + G+   ++ QPS
Sbjct: 363 FDFAFDREALTRERIKEAIVAEIEDFHAR-REGIRQQIRFQPS 404


>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
           sapiens]
          Length = 816

 Score =  179 bits (455), Expect = 2e-45
 Identities = 108/283 (38%), Positives = 167/283 (59%), Gaps = 28/283 (9%)

Query: 1   MELMDANLCQVIQME--LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL 58
           ++LM+++L Q+I     L  E + Y LYQ+L G+K++HSA +IHRDLKPSN++V  +C L
Sbjct: 137 LDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCEL 196

Query: 59  KILDFGLARTAGTS-----FMMTPYVVTRYYRAPEVILGM-GYKENVDIWSVGCIMGEMV 112
           KI DFG+AR   TS     + MT YV TR+YRAPE++L +  Y + +D+WSVGCI GEM+
Sbjct: 197 KIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEML 256

Query: 113 RHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL-QPTVRNYVENRPKYAGLTFPKLFPDS 171
             + LFPG++Y+ Q   ++  LGTP P  ++ +    VR Y+++ P    + +  ++P +
Sbjct: 257 ARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGA 316

Query: 172 LFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDP-AEVEAPPPQI 230
                         QA  LL +ML  +P+ RIS   AL+HP++  ++DP  E +  PP  
Sbjct: 317 ------------DRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPP-- 362

Query: 231 YDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGV---VKGQPS 270
           +D   D    T E  KE I  E+ +   + + G+   ++ QPS
Sbjct: 363 FDFAFDREALTRERIKEAIVAEIEDFHAR-REGIRQQIRFQPS 404


>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
           sapiens]
          Length = 816

 Score =  179 bits (455), Expect = 2e-45
 Identities = 108/283 (38%), Positives = 167/283 (59%), Gaps = 28/283 (9%)

Query: 1   MELMDANLCQVIQME--LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL 58
           ++LM+++L Q+I     L  E + Y LYQ+L G+K++HSA +IHRDLKPSN++V  +C L
Sbjct: 137 LDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCEL 196

Query: 59  KILDFGLARTAGTS-----FMMTPYVVTRYYRAPEVILGM-GYKENVDIWSVGCIMGEMV 112
           KI DFG+AR   TS     + MT YV TR+YRAPE++L +  Y + +D+WSVGCI GEM+
Sbjct: 197 KIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEML 256

Query: 113 RHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL-QPTVRNYVENRPKYAGLTFPKLFPDS 171
             + LFPG++Y+ Q   ++  LGTP P  ++ +    VR Y+++ P    + +  ++P +
Sbjct: 257 ARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGA 316

Query: 172 LFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDP-AEVEAPPPQI 230
                         QA  LL +ML  +P+ RIS   AL+HP++  ++DP  E +  PP  
Sbjct: 317 ------------DRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPP-- 362

Query: 231 YDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGV---VKGQPS 270
           +D   D    T E  KE I  E+ +   + + G+   ++ QPS
Sbjct: 363 FDFAFDREALTRERIKEAIVAEIEDFHAR-REGIRQQIRFQPS 404


>gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo
           sapiens]
          Length = 677

 Score =  176 bits (447), Expect = 2e-44
 Identities = 107/280 (38%), Positives = 164/280 (58%), Gaps = 28/280 (10%)

Query: 4   MDANLCQVIQME--LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKIL 61
           M+++L Q+I     L  E + Y LYQ+L G+K++HSA +IHRDLKPSN++V  +C LKI 
Sbjct: 1   MESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIG 60

Query: 62  DFGLARTAGTS-----FMMTPYVVTRYYRAPEVILGM-GYKENVDIWSVGCIMGEMVRHK 115
           DFG+AR   TS     + MT YV TR+YRAPE++L +  Y + +D+WSVGCI GEM+  +
Sbjct: 61  DFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARR 120

Query: 116 ILFPGRDYIDQWNKVIEQLGTPCPEFMKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFP 174
            LFPG++Y+ Q   ++  LGTP P  ++ +    VR Y+++ P    + +  ++P +   
Sbjct: 121 QLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGA--- 177

Query: 175 ADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDP-AEVEAPPPQIYDK 233
                      QA  LL +ML  +P+ RIS   AL+HP++  ++DP  E +  PP  +D 
Sbjct: 178 ---------DRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPP--FDF 226

Query: 234 QLDEREHTIEEWKELIYKEVMNSEEKTKNGV---VKGQPS 270
             D    T E  KE I  E+ +   + + G+   ++ QPS
Sbjct: 227 AFDREALTRERIKEAIVAEIEDFHAR-REGIRQQIRFQPS 265


>gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo
           sapiens]
          Length = 297

 Score =  160 bits (404), Expect = 1e-39
 Identities = 82/169 (48%), Positives = 116/169 (68%), Gaps = 5/169 (2%)

Query: 3   LMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKIL 61
           LM A+L  +++ + L  + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKIL
Sbjct: 108 LMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKIL 167

Query: 62  DFGLARTAGTSFMMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPG 120
           DFGLAR   T   MT YV TR+YRAPE++L  M Y + VDIWSVGCIM E++  + LFPG
Sbjct: 168 DFGLAR--HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPG 225

Query: 121 RDYIDQWNKVIEQLGTPCPEFMKKL-QPTVRNYVENRPKYAGLTFPKLF 168
            D+IDQ   ++  +GTP  E +KK+   + RNY+++  +   + F  +F
Sbjct: 226 TDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVF 274


>gi|149408126 nemo like kinase [Homo sapiens]
          Length = 527

 Score =  157 bits (398), Expect = 7e-39
 Identities = 93/219 (42%), Positives = 134/219 (61%), Gaps = 15/219 (6%)

Query: 2   ELMDANLCQVI--QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLK 59
           ELM ++L ++I     L  + +   LYQ+L G+K+LHSAGI+HRD+KP N++V S+C LK
Sbjct: 220 ELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLK 279

Query: 60  ILDFGLART--AGTSFMMTPYVVTRYYRAPEVILGMGYKEN-VDIWSVGCIMGEMVRHKI 116
           I DFGLAR      S  MT  VVT+YYRAPE+++G  +  N +DIWSVGCI  E++  +I
Sbjct: 280 ICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRI 339

Query: 117 LFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPAD 176
           LF  +  I Q + + + LGTP  E M+      + ++   P +   + P L+  S   + 
Sbjct: 340 LFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGP-HKQPSLPVLYTLS---SQ 395

Query: 177 SEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 215
           + H      +A  LL +MLV DP+KRIS  DAL HPY++
Sbjct: 396 ATH------EAVHLLCRMLVFDPSKRISAKDALAHPYLD 428


>gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo
           sapiens]
          Length = 307

 Score =  152 bits (384), Expect = 3e-37
 Identities = 77/145 (53%), Positives = 104/145 (71%), Gaps = 4/145 (2%)

Query: 3   LMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKIL 61
           LM A+L  +++ + L  + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V  DC LKIL
Sbjct: 108 LMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKIL 167

Query: 62  DFGLARTAGTSFMMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPG 120
           DFGLAR   T   MT YV TR+YRAPE++L  M Y + VDIWSVGCIM E++  + LFPG
Sbjct: 168 DFGLAR--HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPG 225

Query: 121 RDYIDQWNKVIEQLGTPCPEFMKKL 145
            D+IDQ   ++  +GTP  E +KK+
Sbjct: 226 TDHIDQLKLILRLVGTPGAELLKKI 250


>gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]
          Length = 544

 Score =  152 bits (384), Expect = 3e-37
 Identities = 96/287 (33%), Positives = 155/287 (54%), Gaps = 34/287 (11%)

Query: 2   ELMDANLCQVIQME--LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLK 59
           E MD +L  VI+    L    +  + YQ+L   + LHS  ++HRD KPSN+++ ++CT+K
Sbjct: 93  EFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVK 152

Query: 60  ILDFGLARTAG------TSFMMTPYVVTRYYRAPEVILGM-GYKENVDIWSVGCIMGEMV 112
           + DFGLAR+ G          +T YV TR+YRAPEV+L    Y   VD+WS+GCI+GEM+
Sbjct: 153 LCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEML 212

Query: 113 RHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL----QPTVRNYVENRPKYAGLTFPKLF 168
           R + LFPG   + Q   ++E +  P  E +  L    + +V + + +RP+          
Sbjct: 213 RGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRASVLHQLGSRPRQT-------- 264

Query: 169 PDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPP 228
            D+L P D+      + +A DLL ++LV  P KR+S   ALQHPY+  ++ P++  A   
Sbjct: 265 LDALLPPDT------SPEALDLLRRLLVFAPDKRLSATQALQHPYVQRFHCPSDEWAREA 318

Query: 229 QIYDKQLDEREHTIEEWKELIYKEVM-------NSEEKTKNGVVKGQ 268
            +  +  +  + ++ E++  +Y+ ++        S EK   GV   Q
Sbjct: 319 DVRPRAHEGVQLSVPEYRSRVYQMILECGGSSGTSREKGPEGVSPSQ 365


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.415 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,523,094
Number of Sequences: 37866
Number of extensions: 520214
Number of successful extensions: 3003
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 760
Number of HSP's successfully gapped in prelim test: 43
Number of HSP's that attempted gapping in prelim test: 1209
Number of HSP's gapped (non-prelim): 1092
length of query: 277
length of database: 18,247,518
effective HSP length: 101
effective length of query: 176
effective length of database: 14,423,052
effective search space: 2538457152
effective search space used: 2538457152
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.