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Search of human proteins with 209863028
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|209863028 transient receptor potential cation channel,
subfamily C, member 4 isoform gamma [Homo sapiens]
(828 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|209863028 transient receptor potential cation channel, subfam... 1646 0.0
gi|209863026 transient receptor potential cation channel, subfam... 1527 0.0
gi|209863030 transient receptor potential cation channel, subfam... 1448 0.0
gi|7706747 transient receptor potential cation channel, subfamil... 1312 0.0
gi|209863024 transient receptor potential cation channel, subfam... 1259 0.0
gi|6912736 transient receptor potential cation channel, subfamil... 1065 0.0
gi|209863032 transient receptor potential cation channel, subfam... 736 0.0
gi|4507685 transient receptor potential cation channel, subfamil... 531 e-150
gi|9966865 transient receptor potential cation channel, subfamil... 451 e-126
gi|194733735 transient receptor potential cation channel, subfam... 442 e-124
gi|4507687 transient receptor potential cation channel, subfamil... 442 e-124
gi|5730102 transient receptor potential cation channel, subfamil... 439 e-123
gi|169216484 PREDICTED: similar to transient receptor potential ... 144 4e-34
gi|109689695 transient receptor potential cation channel, subfam... 99 2e-20
gi|239754785 PREDICTED: similar to transient receptor potential ... 80 8e-15
gi|239749299 PREDICTED: similar to transient receptor potential ... 80 8e-15
gi|239743393 PREDICTED: hypothetical protein XP_002342847, parti... 80 8e-15
gi|239509090 PREDICTED: similar to transient receptor potential ... 80 8e-15
gi|94538366 transient receptor potential cation channel, subfami... 78 4e-14
gi|4507689 transient receptor potential cation channel, subfamil... 72 3e-12
gi|18921093 transient receptor potential cation channel, subfami... 71 4e-12
gi|148612863 transient receptor potential cation channel, subfam... 68 4e-11
gi|154091312 transient receptor potential cation channel, subfam... 62 2e-09
gi|154091308 transient receptor potential cation channel, subfam... 62 2e-09
gi|154091310 transient receptor potential cation channel, subfam... 62 2e-09
gi|154091320 transient receptor potential cation channel, subfam... 62 2e-09
gi|154091318 transient receptor potential cation channel, subfam... 62 2e-09
gi|154091316 transient receptor potential cation channel, subfam... 62 2e-09
gi|154091314 transient receptor potential cation channel, subfam... 62 2e-09
gi|4505835 polycystin 2 [Homo sapiens] 50 7e-06
>gi|209863028 transient receptor potential cation channel, subfamily
C, member 4 isoform gamma [Homo sapiens]
Length = 828
Score = 1646 bits (4262), Expect = 0.0
Identities = 828/828 (100%), Positives = 828/828 (100%)
Query: 1 MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK
Sbjct: 1 MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
Query: 61 ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK
Sbjct: 61 ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
Query: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180
PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE
Sbjct: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180
Query: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240
CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE
Sbjct: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240
Query: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF 300
YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF
Sbjct: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF 300
Query: 301 VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR 360
VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR
Sbjct: 301 VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR 360
Query: 361 KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ 420
KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ
Sbjct: 361 KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ 420
Query: 421 MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL 480
MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL
Sbjct: 421 MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL 480
Query: 481 FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY 540
FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY
Sbjct: 481 FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY 540
Query: 541 YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM 600
YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM
Sbjct: 541 YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM 600
Query: 601 FGTYNVISLVVLLNMLIAMMNNSYQLIARRAADNLRRHHQYQEVMRNLVKRYVAAMIRDA 660
FGTYNVISLVVLLNMLIAMMNNSYQLIARRAADNLRRHHQYQEVMRNLVKRYVAAMIRDA
Sbjct: 601 FGTYNVISLVVLLNMLIAMMNNSYQLIARRAADNLRRHHQYQEVMRNLVKRYVAAMIRDA 660
Query: 661 KTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSADSDEKSDSEE 720
KTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSADSDEKSDSEE
Sbjct: 661 KTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSADSDEKSDSEE 720
Query: 721 EVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDHRERNTDTLGLQVGKRVCP 780
EVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDHRERNTDTLGLQVGKRVCP
Sbjct: 721 EVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDHRERNTDTLGLQVGKRVCP 780
Query: 781 FKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHEDYVTTRL 828
FKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHEDYVTTRL
Sbjct: 781 FKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHEDYVTTRL 828
>gi|209863026 transient receptor potential cation channel, subfamily
C, member 4 isoform beta [Homo sapiens]
Length = 893
Score = 1527 bits (3954), Expect = 0.0
Identities = 792/893 (88%), Positives = 803/893 (89%), Gaps = 65/893 (7%)
Query: 1 MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK
Sbjct: 1 MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
Query: 61 ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK
Sbjct: 61 ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
Query: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180
PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE
Sbjct: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180
Query: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240
CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE
Sbjct: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240
Query: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF 300
YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF
Sbjct: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF 300
Query: 301 VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR 360
VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR
Sbjct: 301 VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR 360
Query: 361 KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ 420
KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ
Sbjct: 361 KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ 420
Query: 421 MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL 480
MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL
Sbjct: 421 MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL 480
Query: 481 FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY 540
FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY
Sbjct: 481 FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY 540
Query: 541 YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFG----------------------- 577
YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFG
Sbjct: 541 YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM 600
Query: 578 -----------LINLYVTNVK------AQHEFTEFV-------------GATMFGTYNVI 607
L+N+ + + A H E+ G T+ +NVI
Sbjct: 601 FGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVI 660
Query: 608 ----SLVVLLNML--------IAMMNNSYQLIARRAADNLRRHHQYQEVMRNLVKRYVAA 655
SL L+ + + S+ I RRAADNLRRHHQYQEVMRNLVKRYVAA
Sbjct: 661 PSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAA 720
Query: 656 MIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSADSDEK 715
MIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSADSDEK
Sbjct: 721 MIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSADSDEK 780
Query: 716 SDSEEEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDHRERNTDTLGLQVG 775
SDSEEEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDHRERNTDTLGLQVG
Sbjct: 781 SDSEEEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDHRERNTDTLGLQVG 840
Query: 776 KRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHEDYVTTRL 828
KRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHEDYVTTRL
Sbjct: 841 KRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHEDYVTTRL 893
>gi|209863030 transient receptor potential cation channel, subfamily
C, member 4 isoform delta [Homo sapiens]
Length = 836
Score = 1448 bits (3748), Expect = 0.0
Identities = 754/842 (89%), Positives = 767/842 (91%), Gaps = 20/842 (2%)
Query: 1 MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK
Sbjct: 1 MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
Query: 61 ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK
Sbjct: 61 ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
Query: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180
PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE
Sbjct: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180
Query: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240
CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE
Sbjct: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240
Query: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF 300
YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF
Sbjct: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF 300
Query: 301 VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR 360
VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR
Sbjct: 301 VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR 360
Query: 361 KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ 420
KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ
Sbjct: 361 KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ 420
Query: 421 MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL 480
MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL
Sbjct: 421 MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL 480
Query: 481 FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY 540
FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY
Sbjct: 481 FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY 540
Query: 541 YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM 600
YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM
Sbjct: 541 YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM 600
Query: 601 FGTYNVISLVVLLNMLIAMMNNSYQLIARRA-----ADNLRRHHQYQEVMRNLVKRYVAA 655
FGTYNVISLVVLLNMLIAMMNNSYQLIA A + Y E L +
Sbjct: 601 FGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPF--N 658
Query: 656 MIRDAKTEEGL-----TEENFKELKQDISSF----RFEVLGLLRGSKLSTIQSANASKES 706
+I K+ L T K++++ SF R L R + + N K
Sbjct: 659 VIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGRRAADNLRRHHQYQEVM-RNLVKRY 717
Query: 707 SNSADSDEKSDSEEEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDHRERN 766
+ D K++ EVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDHRERN
Sbjct: 718 VAAMIRDAKTE---EVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDHRERN 774
Query: 767 TDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHEDYVTT 826
TDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHEDYVTT
Sbjct: 775 TDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHEDYVTT 834
Query: 827 RL 828
RL
Sbjct: 835 RL 836
>gi|7706747 transient receptor potential cation channel, subfamily
C, member 4 isoform alpha [Homo sapiens]
Length = 977
Score = 1312 bits (3396), Expect = 0.0
Identities = 683/784 (87%), Positives = 694/784 (88%), Gaps = 65/784 (8%)
Query: 1 MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK
Sbjct: 1 MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
Query: 61 ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK
Sbjct: 61 ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
Query: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180
PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE
Sbjct: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180
Query: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240
CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE
Sbjct: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240
Query: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF 300
YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF
Sbjct: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF 300
Query: 301 VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR 360
VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR
Sbjct: 301 VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR 360
Query: 361 KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ 420
KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ
Sbjct: 361 KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ 420
Query: 421 MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL 480
MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL
Sbjct: 421 MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL 480
Query: 481 FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY 540
FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY
Sbjct: 481 FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY 540
Query: 541 YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFG----------------------- 577
YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFG
Sbjct: 541 YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM 600
Query: 578 -----------LINLYVTNVK------AQHEFTEFV-------------GATMFGTYNVI 607
L+N+ + + A H E+ G T+ +NVI
Sbjct: 601 FGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVI 660
Query: 608 ----SLVVLLNML--------IAMMNNSYQLIARRAADNLRRHHQYQEVMRNLVKRYVAA 655
SL L+ + + S+ I RRAADNLRRHHQYQEVMRNLVKRYVAA
Sbjct: 661 PSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAA 720
Query: 656 MIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSADSDEK 715
MIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSADSDEK
Sbjct: 721 MIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSADSDEK 780
Query: 716 SDSE 719
SDSE
Sbjct: 781 SDSE 784
Score = 222 bits (566), Expect = 1e-57
Identities = 111/126 (88%), Positives = 118/126 (93%)
Query: 703 SKESSNSADSDEKSDSEEEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDH 762
SK+++ ++++ EEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDH
Sbjct: 852 SKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDH 911
Query: 763 RERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHED 822
RERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHED
Sbjct: 912 RERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHED 971
Query: 823 YVTTRL 828
YVTTRL
Sbjct: 972 YVTTRL 977
>gi|209863024 transient receptor potential cation channel, subfamily
C, member 4 isoform epsilon [Homo sapiens]
Length = 982
Score = 1259 bits (3259), Expect = 0.0
Identities = 629/631 (99%), Positives = 629/631 (99%)
Query: 1 MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK
Sbjct: 1 MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
Query: 61 ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK
Sbjct: 61 ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
Query: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180
PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE
Sbjct: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180
Query: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240
CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE
Sbjct: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240
Query: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF 300
YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF
Sbjct: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF 300
Query: 301 VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR 360
VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR
Sbjct: 301 VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR 360
Query: 361 KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ 420
KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ
Sbjct: 361 KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ 420
Query: 421 MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL 480
MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL
Sbjct: 421 MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL 480
Query: 481 FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY 540
FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY
Sbjct: 481 FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY 540
Query: 541 YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM 600
YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM
Sbjct: 541 YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM 600
Query: 601 FGTYNVISLVVLLNMLIAMMNNSYQLIARRA 631
FGTYNVISLVVLLNMLIAMMNNSYQLIA A
Sbjct: 601 FGTYNVISLVVLLNMLIAMMNNSYQLIADHA 631
Score = 222 bits (566), Expect = 1e-57
Identities = 111/126 (88%), Positives = 118/126 (93%)
Query: 703 SKESSNSADSDEKSDSEEEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDH 762
SK+++ ++++ EEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDH
Sbjct: 857 SKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDH 916
Query: 763 RERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHED 822
RERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHED
Sbjct: 917 RERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHED 976
Query: 823 YVTTRL 828
YVTTRL
Sbjct: 977 YVTTRL 982
Score = 176 bits (447), Expect = 6e-44
Identities = 91/91 (100%), Positives = 91/91 (100%)
Query: 629 RRAADNLRRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGL 688
RRAADNLRRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGL
Sbjct: 699 RRAADNLRRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGL 758
Query: 689 LRGSKLSTIQSANASKESSNSADSDEKSDSE 719
LRGSKLSTIQSANASKESSNSADSDEKSDSE
Sbjct: 759 LRGSKLSTIQSANASKESSNSADSDEKSDSE 789
>gi|6912736 transient receptor potential cation channel, subfamily
C, member 5 [Homo sapiens]
Length = 973
Score = 1065 bits (2753), Expect = 0.0
Identities = 520/636 (81%), Positives = 587/636 (92%), Gaps = 6/636 (0%)
Query: 1 MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
MAQ YYK+ +PYRDRIPL+IVRAE+ELS EKA+LNAVEKGDYA+VK++L+EAEIY+
Sbjct: 1 MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYN 60
Query: 61 ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
+NINC+DPLGR+ALLIAIENENLE++ELLL+ +VYVGDALL+AIRKEVVGAVELLL++++
Sbjct: 61 VNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRR 120
Query: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180
PSGEKQVP +++D QFSEFTPDITPI+LAAHTNNYEIIKLLVQK V++PRPH++RCNCVE
Sbjct: 121 PSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVE 180
Query: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240
CVSSS+VDSLRHSRSRLNIYKALASPSLIALSSEDP LTAF+L WEL+ELSKVENEFK+E
Sbjct: 181 CVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAE 240
Query: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSL-IEEQSGNDLARLKLAIKYRQKE 299
YEELS+QCK FAKDLLDQ RSSRELEIILN+RDD+S ++ Q +DLA+LK+AIKY QKE
Sbjct: 241 YEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKE 300
Query: 300 FVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFI 359
FVAQPNCQQLLA+ WYD FPGWRR+HW VK++TC IG LFP+ S+ YLI+P+S LGLFI
Sbjct: 301 FVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFI 360
Query: 360 RKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIK 419
+KPFIKFICHTASYLTFLF+LLLASQHI R+DL+ QGPPPT+VEWMILPWVLGFIWGEIK
Sbjct: 361 KKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIK 420
Query: 420 QMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEA 479
+MWDGG +YIHDWWNLMDF MNSLYLATISLKIVA+VKY+ PRE W+MWHPTL+AEA
Sbjct: 421 EMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEA 480
Query: 480 LFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF 539
LFAI+NI SSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF
Sbjct: 481 LFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF 540
Query: 540 YYEETKGL----TCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEF 595
YY ET+ + CKGIRCEKQNNAFSTLFETLQSLFWS+FGL+NLYVTNVKA+HEFTEF
Sbjct: 541 YY-ETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEF 599
Query: 596 VGATMFGTYNVISLVVLLNMLIAMMNNSYQLIARRA 631
VGATMFGTYNVISLVVLLNMLIAMMNNSYQLIA A
Sbjct: 600 VGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHA 635
>gi|209863032 transient receptor potential cation channel, subfamily
C, member 4 isoform zeta [Homo sapiens]
Length = 804
Score = 736 bits (1900), Expect = 0.0
Identities = 385/488 (78%), Positives = 398/488 (81%), Gaps = 65/488 (13%)
Query: 297 QKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLG 356
+K+FVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLG
Sbjct: 124 EKQFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLG 183
Query: 357 LFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWG 416
LFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWG
Sbjct: 184 LFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWG 243
Query: 417 EIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLV 476
EIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLV
Sbjct: 244 EIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLV 303
Query: 477 AEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQ 536
AEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQ
Sbjct: 304 AEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQ 363
Query: 537 LYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFG------------------- 577
LYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFG
Sbjct: 364 LYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFV 423
Query: 578 ---------------LINLYVTNVK------AQHEFTEFV-------------GATMFGT 603
L+N+ + + A H E+ G T+
Sbjct: 424 GATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTP 483
Query: 604 YNVI----SLVVLLNML--------IAMMNNSYQLIARRAADNLRRHHQYQEVMRNLVKR 651
+NVI SL L+ + + S+ I RRAADNLRRHHQYQEVMRNLVKR
Sbjct: 484 FNVIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKR 543
Query: 652 YVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSAD 711
YVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSAD
Sbjct: 544 YVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSAD 603
Query: 712 SDEKSDSE 719
SDEKSDSE
Sbjct: 604 SDEKSDSE 611
Score = 247 bits (630), Expect = 4e-65
Identities = 126/126 (100%), Positives = 126/126 (100%)
Query: 1 MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK
Sbjct: 1 MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
Query: 61 ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK
Sbjct: 61 ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
Query: 121 PSGEKQ 126
PSGEKQ
Sbjct: 121 PSGEKQ 126
Score = 222 bits (566), Expect = 1e-57
Identities = 111/126 (88%), Positives = 118/126 (93%)
Query: 703 SKESSNSADSDEKSDSEEEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDH 762
SK+++ ++++ EEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDH
Sbjct: 679 SKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDH 738
Query: 763 RERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHED 822
RERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHED
Sbjct: 739 RERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHED 798
Query: 823 YVTTRL 828
YVTTRL
Sbjct: 799 YVTTRL 804
>gi|4507685 transient receptor potential cation channel, subfamily
C, member 1 [Homo sapiens]
Length = 759
Score = 531 bits (1368), Expect = e-150
Identities = 293/619 (47%), Positives = 402/619 (64%), Gaps = 46/619 (7%)
Query: 20 LRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIE 79
+R V+ E+ L+ EK +L A +KGDY VKK LEE +NINC+D LGR A+ I IE
Sbjct: 37 VREVKEENTLN--EKLFLLACDKGDYYMVKKILEENSSG-DLNINCVDVLGRNAVTITIE 93
Query: 80 NENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEF 139
NENL++++LLL + G +L+ + P ++S
Sbjct: 94 NENLDILQLLLDY-----------------GCQKLMERIQNP-------------EYST- 122
Query: 140 TPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNI 199
T D+ P+ILAAH NNYEI+ +L+++ VS+P+PH V C C C + + DSLRHSR RL+I
Sbjct: 123 TMDVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDI 182
Query: 200 YKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQT 259
Y+ LASP+LI L+ EDP L AF+LS +L+ELS VE EF+++YEEL+RQCK FAKDLL Q
Sbjct: 183 YRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQA 242
Query: 260 RSSRELEIILNYR------DDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASR 313
R+SRELE+ILN+ D L+EE+ +L+RLKLAIKY QKEFV+Q NCQQ L +
Sbjct: 243 RNSRELEVILNHTSSDEPLDKRGLLEERM--NLSRLKLAIKYNQKEFVSQSNCQQFLNTV 300
Query: 314 WYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASY 373
W+ + G+RR+ K++T +G+ +PV S+CYLIAPKS G I PF+KFI H ASY
Sbjct: 301 WFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASY 360
Query: 374 LTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDW 433
TFL LL L S + N GP ++++++ W++G IW +IK++W GL+D++ +
Sbjct: 361 FTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEES 420
Query: 434 WNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLI 493
N + FVMNSLYLAT +LK+VA K+ R+ WD +HPTLVAE LFA AN+ S LRL
Sbjct: 421 RNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLF 480
Query: 494 SLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY-YEETKGLTCKGI 552
++T +S LGPLQIS+G+ML D KFL ++ LVL +F GL QLY Y + C GI
Sbjct: 481 FMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGI 540
Query: 553 RCEKQ-NNAFSTLFETLQSLFWSIFGL--INLYVTNVKAQHEFTEFVGATMFGTYNVISL 609
CE+Q N+ F + T +LFW IF L + ++VT E FVGA + GTYNV+ +
Sbjct: 541 FCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVV 600
Query: 610 VVLLNMLIAMMNNSYQLIA 628
+VL +L+AM++ S+QLIA
Sbjct: 601 IVLTKLLVAMLHKSFQLIA 619
Score = 46.2 bits (108), Expect = 1e-04
Identities = 27/68 (39%), Positives = 39/68 (57%), Gaps = 2/68 (2%)
Query: 636 RRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLL--RGSK 693
+R YQ+VM LV RY+ +M + ++ + T EN EL+QD+S FR E+ LL R SK
Sbjct: 692 KRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSK 751
Query: 694 LSTIQSAN 701
+ N
Sbjct: 752 YAMFYPRN 759
>gi|9966865 transient receptor potential cation channel, subfamily
C, member 7 [Homo sapiens]
Length = 862
Score = 451 bits (1161), Expect = e-126
Identities = 265/662 (40%), Positives = 379/662 (57%), Gaps = 73/662 (11%)
Query: 27 SELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELI 86
+ L+P E+ +L++ E G+ V+K LEE++ +N NC+D +G+ AL +A+ NE+LE+
Sbjct: 38 TSLTPEEERFLDSAEYGNIPVVRKMLEESKT---LNFNCVDYMGQNALQLAVGNEHLEVT 94
Query: 87 ELLLSFN--VYVGDALLHAIRKEVVGAVELLLNHKK-PSGEK-QVPPI----------LL 132
ELLL VGDALL AI K V VE +LNH G++ + P+
Sbjct: 95 ELLLKKENLARVGDALLLAISKGYVRIVEAILNHPAFAQGQRLTLSPLEQELRDDDFYAY 154
Query: 133 DKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRH 192
D+ + F+ DITPIILAAH YEI+ +L+ KG + RPH+ C C EC DS H
Sbjct: 155 DEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSH 214
Query: 193 SRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFA 252
SRSR+N YK LAS + ++LSSEDP LTA +LS EL L+ +E EFK++Y +LS QCK F
Sbjct: 215 SRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQCKDFV 274
Query: 253 KDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLAS 312
+LD R + E+E ILN + + + L+R+KLAIKY K+FVA PNCQQ L +
Sbjct: 275 VGVLDLCRDTEEVEAILNGDVNFQVWSDHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLT 334
Query: 313 RWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTAS 372
WY+ G R++ AVK + F + + P ++ Y IAP S LG +R PF+KF+ H S
Sbjct: 335 MWYENLSGLRQQSIAVKFLAVFGVSIGLPFLAIAYWIAPCSKLGRTLRSPFMKFVAHAVS 394
Query: 373 YLTFLFLLLLASQHIDRSDLNRQGPPPTI-----------------VEWMILPWVLGFIW 415
+ FL LL++ + DR + + P T E +I+ WVLG IW
Sbjct: 395 FTIFLGLLVVNAS--DRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIW 452
Query: 416 GEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYS--------------- 460
E K++W+ G ++Y+ WNL+DF M S+++A+ + + +AF+K +
Sbjct: 453 SECKEIWEEGPREYVLHLWNLLDFGMLSIFVASFTARFMAFLKATEAQLYVDQHVQDDTL 512
Query: 461 ---ALNP--------RESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISL 509
+L P R+ W P +++E L+AIA + S R+ + AN GPLQISL
Sbjct: 513 HNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISL 572
Query: 510 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQ 569
GR + DI KF+ I+ +V +AF G+ LY YY R K N AF+T+ E+ +
Sbjct: 573 GRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYY-----------RGAKYNPAFTTVEESFK 621
Query: 570 SLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIAR 629
+LFWSIFGL + +K H+F E +G ++G YNV +VVLLNMLIAM+NNSYQ I
Sbjct: 622 TLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEE 681
Query: 630 RA 631
A
Sbjct: 682 DA 683
Score = 48.9 bits (115), Expect = 2e-05
Identities = 29/69 (42%), Positives = 42/69 (60%), Gaps = 4/69 (5%)
Query: 618 AMMNNSYQLIARRAADNLRRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQD 677
A M NS L A + L + +YQ++M+ L+KRYV D + +E + E KE+KQD
Sbjct: 760 AGMRNSENLTAN---NTLSKPTRYQKIMKRLIKRYVLKAQVDRENDE-VNEGELKEIKQD 815
Query: 678 ISSFRFEVL 686
ISS R+E+L
Sbjct: 816 ISSLRYELL 824
>gi|194733735 transient receptor potential cation channel, subfamily
C, member 3 isoform a [Homo sapiens]
Length = 921
Score = 442 bits (1137), Expect = e-124
Identities = 259/658 (39%), Positives = 375/658 (56%), Gaps = 71/658 (10%)
Query: 27 SELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELI 86
+ L+ E+ +L+A E G+ V+K LEE++ +N+NC+D +G+ AL +A+ NE+LE+
Sbjct: 107 TSLTAEEERFLDAAEYGNIPVVRKMLEESKT---LNVNCVDYMGQNALQLAVGNEHLEVT 163
Query: 87 ELLLSFN--VYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPP------------ILL 132
ELLL +GDALL AI K V VE +LNH + K++
Sbjct: 164 ELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAY 223
Query: 133 DKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRH 192
D+ + F+PDITPIILAAH YE++ +L+ KG + RPH+ C C +C+ DS H
Sbjct: 224 DEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSH 283
Query: 193 SRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFA 252
SRSR+N YK LASP+ ++LSSEDP LTA +LS EL +L+ +E EFK++Y +LS QCK F
Sbjct: 284 SRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFV 343
Query: 253 KDLLDQTRSSRELEIILN--YRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLL 310
+LD R S E+E ILN L + L+R+KLAIKY K+FVA PNCQQ L
Sbjct: 344 VGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQL 403
Query: 311 ASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHT 370
+ WY+ G R + A+K + ++ L P ++ Y IAP S LG +R PF+KF+ H
Sbjct: 404 LTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHA 463
Query: 371 ASYLTFLFLLLLASQ----------HIDRSDLNRQ-----GPPPTIVEWMILPWVLGFIW 415
AS++ FL LL+ + +I +D +Q T E +I+ WVLG +W
Sbjct: 464 ASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMW 523
Query: 416 GEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYS--------------- 460
E K++W G ++YI WN++DF M S+++A + + +AF++ +
Sbjct: 524 SECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDL 583
Query: 461 ---ALNP--------RESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISL 509
L P R+ W P +++E L+AIA + S R+ + AN GPLQISL
Sbjct: 584 SEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISL 643
Query: 510 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQ 569
GR + DI KF+ ++ +V AF G+ LY YY K N AF+T+ E+ +
Sbjct: 644 GRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGA-----------KVNAAFTTVEESFK 692
Query: 570 SLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLI 627
+LFWSIFGL + +K H+F E +G ++G YNV +VVLLNMLIAM+N+SYQ I
Sbjct: 693 TLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEI 750
Score = 46.2 bits (108), Expect = 1e-04
Identities = 23/52 (44%), Positives = 35/52 (67%), Gaps = 1/52 (1%)
Query: 635 LRRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVL 686
L + +YQ++M+ L+KRYV D + +E + E KE+KQDISS R+E+L
Sbjct: 842 LNQPTRYQQIMKRLIKRYVLKAQVDKENDE-VNEGELKEIKQDISSLRYELL 892
>gi|4507687 transient receptor potential cation channel, subfamily
C, member 3 isoform b [Homo sapiens]
Length = 848
Score = 442 bits (1137), Expect = e-124
Identities = 259/658 (39%), Positives = 375/658 (56%), Gaps = 71/658 (10%)
Query: 27 SELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELI 86
+ L+ E+ +L+A E G+ V+K LEE++ +N+NC+D +G+ AL +A+ NE+LE+
Sbjct: 34 TSLTAEEERFLDAAEYGNIPVVRKMLEESKT---LNVNCVDYMGQNALQLAVGNEHLEVT 90
Query: 87 ELLLSFN--VYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPP------------ILL 132
ELLL +GDALL AI K V VE +LNH + K++
Sbjct: 91 ELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAY 150
Query: 133 DKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRH 192
D+ + F+PDITPIILAAH YE++ +L+ KG + RPH+ C C +C+ DS H
Sbjct: 151 DEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSH 210
Query: 193 SRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFA 252
SRSR+N YK LASP+ ++LSSEDP LTA +LS EL +L+ +E EFK++Y +LS QCK F
Sbjct: 211 SRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFV 270
Query: 253 KDLLDQTRSSRELEIILN--YRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLL 310
+LD R S E+E ILN L + L+R+KLAIKY K+FVA PNCQQ L
Sbjct: 271 VGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQL 330
Query: 311 ASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHT 370
+ WY+ G R + A+K + ++ L P ++ Y IAP S LG +R PF+KF+ H
Sbjct: 331 LTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHA 390
Query: 371 ASYLTFLFLLLLASQ----------HIDRSDLNRQ-----GPPPTIVEWMILPWVLGFIW 415
AS++ FL LL+ + +I +D +Q T E +I+ WVLG +W
Sbjct: 391 ASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMW 450
Query: 416 GEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYS--------------- 460
E K++W G ++YI WN++DF M S+++A + + +AF++ +
Sbjct: 451 SECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDL 510
Query: 461 ---ALNP--------RESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISL 509
L P R+ W P +++E L+AIA + S R+ + AN GPLQISL
Sbjct: 511 SEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISL 570
Query: 510 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQ 569
GR + DI KF+ ++ +V AF G+ LY YY K N AF+T+ E+ +
Sbjct: 571 GRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGA-----------KVNAAFTTVEESFK 619
Query: 570 SLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLI 627
+LFWSIFGL + +K H+F E +G ++G YNV +VVLLNMLIAM+N+SYQ I
Sbjct: 620 TLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEI 677
Score = 46.2 bits (108), Expect = 1e-04
Identities = 23/52 (44%), Positives = 35/52 (67%), Gaps = 1/52 (1%)
Query: 635 LRRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVL 686
L + +YQ++M+ L+KRYV D + +E + E KE+KQDISS R+E+L
Sbjct: 769 LNQPTRYQQIMKRLIKRYVLKAQVDKENDE-VNEGELKEIKQDISSLRYELL 819
>gi|5730102 transient receptor potential cation channel, subfamily
C, member 6 [Homo sapiens]
Length = 931
Score = 439 bits (1130), Expect = e-123
Identities = 256/659 (38%), Positives = 372/659 (56%), Gaps = 75/659 (11%)
Query: 27 SELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELI 86
+ LS E+ +L+A E G+ V+K LEE +N+NC+D +G+ AL +A+ NE+LE+
Sbjct: 93 TSLSIEEERFLDAAEYGNIPVVRKMLEECH---SLNVNCVDYMGQNALQLAVANEHLEIT 149
Query: 87 ELLLSFNVY--VGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPP------------ILL 132
ELLL VGDALL AI K V VE +L+H + K++
Sbjct: 150 ELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAY 209
Query: 133 DKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRH 192
D+ + F+ D+TPIILAAH YEI+ L++KG + RPH+ C C +C DS H
Sbjct: 210 DEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSH 269
Query: 193 SRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFA 252
SRSR+N YK LASP+ ++LSSEDP +TA +LS EL L+ +E EFK++Y++LS QCK F
Sbjct: 270 SRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFV 329
Query: 253 KDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLAS 312
LLD R++ E+E ILN + + +L+RLKLAIKY K+FVA PNCQQ L S
Sbjct: 330 VGLLDLCRNTEEVEAILNGDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLS 389
Query: 313 RWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTAS 372
WY+ G R++ AVK + + + P ++ Y AP S +G +R PF+KF+ H AS
Sbjct: 390 IWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAAS 449
Query: 373 YLTFLFLLLLASQHIDRSDLNRQGPPPTI-----------------VEWMILPWVLGFIW 415
+ FL LL++ + DR + + P T +E +I+ WV+G IW
Sbjct: 450 FTIFLGLLVMNA--ADRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIW 507
Query: 416 GEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAF------------------- 456
E K++W G ++Y+ + WN++DF M +++ A+ + +AF
Sbjct: 508 AECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDL 567
Query: 457 --------VKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQIS 508
VKY L R WD P +++E L+AIA + S R+ + AN GPLQIS
Sbjct: 568 TKVTLGDNVKYYNL-ARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQIS 626
Query: 509 LGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETL 568
LGR + DI KF+ I+ +V +AF G+ LY YY KQN AF+T+ E+
Sbjct: 627 LGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGA-----------KQNEAFTTVEESF 675
Query: 569 QSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLI 627
++LFW+IFGL + + H+F E +G ++G YNV ++VLLNMLIAM+N+S+Q I
Sbjct: 676 KTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEI 734
Score = 47.4 bits (111), Expect = 6e-05
Identities = 23/47 (48%), Positives = 34/47 (72%), Gaps = 1/47 (2%)
Query: 640 QYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVL 686
QYQ++M+ L+KRYV D +++E + E KE+KQDISS R+E+L
Sbjct: 854 QYQKIMKRLIKRYVLQAQIDKESDE-VNEGELKEIKQDISSLRYELL 899
>gi|169216484 PREDICTED: similar to transient receptor potential
channel subfamily C member 6 [Homo sapiens]
Length = 304
Score = 144 bits (362), Expect = 4e-34
Identities = 84/243 (34%), Positives = 129/243 (53%), Gaps = 39/243 (16%)
Query: 412 GFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAF--------------- 456
G IW E K++W G ++Y+ + WN++DF M ++ A+ + AF
Sbjct: 17 GMIWAECKEIWTQGPKEYLFELWNMLDFGMLAILSASFIARFRAFWHASKAQSITDASDT 76
Query: 457 ------------VKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGP 504
VKY +L RE WD P +V+E L A+A + S + + AN GP
Sbjct: 77 LKDLTKVTLGDNVKYYSLARRE-WDPSDPRMVSEGLCAVAVVLSFSGIACILPANESFGP 135
Query: 505 LQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTL 564
LQ+SLG + DI +F+ I+ +V +AF G+ LY YY + K QN AF+T+
Sbjct: 136 LQMSLGGAVKDIFRFMLIFIMVFVAFMIGMFNLYSYYIDVK-----------QNEAFTTV 184
Query: 565 FETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSY 624
E+ ++LFW+ F L + + H+F E +G ++G Y+V ++VLLNMLIAM+N+S
Sbjct: 185 EESFKTLFWATFVLSAVKSVVINYSHKFIENIGYVLYGVYDVTMVIVLLNMLIAMINSSL 244
Query: 625 QLI 627
Q I
Sbjct: 245 QEI 247
>gi|109689695 transient receptor potential cation channel, subfamily
M, member 8 [Homo sapiens]
Length = 1104
Score = 99.0 bits (245), Expect = 2e-20
Identities = 90/327 (27%), Positives = 153/327 (46%), Gaps = 48/327 (14%)
Query: 218 LTAFQLSWELQELSKVENEFKS--EYEELSRQCKQFAKDLLDQTRSSRE--LEIILNYRD 273
L A S L+ L+KV+N+ + E EEL+ + + A +L + SS E E +L Y
Sbjct: 589 LAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYS- 647
Query: 274 DNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTC 333
E G++ L+LA++ + F+AQP Q L+ +WY E ++W K++ C
Sbjct: 648 ----CEAWGGSNC--LELAVEATDQHFIAQPGVQNFLSKQWYGEISR-DTKNW--KIILC 698
Query: 334 FIIGLLFPVFSVCYLIAPKSPLG----------LFIRKPFIKFICHTASYLTFLFLLLLA 383
I P+ ++ K P+ F PF+ F + Y+ FL L
Sbjct: 699 LFI---IPLVGCGFVSFRKKPVDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFA-- 753
Query: 384 SQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNS 443
++ D + PP +V + + V E++Q + G+ +Y D WN+MD +
Sbjct: 754 --YVLLMDFHSVPHPPELVLYSL---VFVLFCDEVRQWYVNGV-NYFTDLWNVMDTLGLF 807
Query: 444 LYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLG 503
++A I ++ + K S + R +F + I +LRLI +FT + +LG
Sbjct: 808 YFIAGIVFRLHSSNKSSLYSGR-------------VIFCLDYIIFTLRLIHIFTVSRNLG 854
Query: 504 PLQISLGRMLLDILKFLFIYCLVLLAF 530
P I L RML+D+ FLF++ + ++AF
Sbjct: 855 PKIIMLQRMLIDVFFFLFLFAVWMVAF 881
>gi|239754785 PREDICTED: similar to transient receptor potential
cation channel, subfamily C, member 6, partial [Homo
sapiens]
Length = 182
Score = 80.1 bits (196), Expect = 8e-15
Identities = 56/180 (31%), Positives = 82/180 (45%), Gaps = 39/180 (21%)
Query: 417 EIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAF-------------------- 456
E K++W G ++Y+ + WN++DF M ++ A + AF
Sbjct: 4 ECKEIWTQGPKEYLFELWNMLDFGMLVIFTALFIARFRAFWHASKAQSIIDANDTLKDLT 63
Query: 457 -------VKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISL 509
VKY L RE W P +V+E L A+A + S + + AN GPLQ SL
Sbjct: 64 EVTLGDNVKYYNLARRE-WVPSDPWVVSEGLCAVAVVLSFSGIACILPANESFGPLQTSL 122
Query: 510 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQ 569
G + DI +F+ I+ +V +AF G+ LY YY KQN AF+TL L+
Sbjct: 123 GGAVKDIFRFMVIFIMVFVAFMIGMFNLYSYYIGA-----------KQNEAFTTLKRVLR 171
>gi|239749299 PREDICTED: similar to transient receptor potential
cation channel, subfamily C, member 6, partial [Homo
sapiens]
Length = 182
Score = 80.1 bits (196), Expect = 8e-15
Identities = 56/180 (31%), Positives = 82/180 (45%), Gaps = 39/180 (21%)
Query: 417 EIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAF-------------------- 456
E K++W G ++Y+ + WN++DF M ++ A + AF
Sbjct: 4 ECKEIWTQGPKEYLFELWNMLDFGMLVIFTALFIARFRAFWHASKAQSIIDANDTLKDLT 63
Query: 457 -------VKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISL 509
VKY L RE W P +V+E L A+A + S + + AN GPLQ SL
Sbjct: 64 EVTLGDNVKYYNLARRE-WVPSDPWVVSEGLCAVAVVLSFSGIACILPANESFGPLQTSL 122
Query: 510 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQ 569
G + DI +F+ I+ +V +AF G+ LY YY KQN AF+TL L+
Sbjct: 123 GGAVKDIFRFMVIFIMVFVAFMIGMFNLYSYYIGA-----------KQNEAFTTLKRVLR 171
>gi|239743393 PREDICTED: hypothetical protein XP_002342847, partial
[Homo sapiens]
Length = 182
Score = 80.1 bits (196), Expect = 8e-15
Identities = 56/180 (31%), Positives = 82/180 (45%), Gaps = 39/180 (21%)
Query: 417 EIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAF-------------------- 456
E K++W G ++Y+ + WN++DF M ++ A + AF
Sbjct: 4 ECKEIWTQGPKEYLFELWNMLDFGMLVIFTALFIARFRAFWHASKAQSIIDANDTLKDLT 63
Query: 457 -------VKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISL 509
VKY L RE W P +V+E L A+A + S + + AN GPLQ SL
Sbjct: 64 EVTLGDNVKYYNLARRE-WVPSDPWVVSEGLCAVAVVLSFSGIACILPANESFGPLQTSL 122
Query: 510 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQ 569
G + DI +F+ I+ +V +AF G+ LY YY KQN AF+TL L+
Sbjct: 123 GGAVKDIFRFMVIFIMVFVAFMIGMFNLYSYYIGA-----------KQNEAFTTLKRVLR 171
>gi|239509090 PREDICTED: similar to transient receptor potential
cation channel, subfamily C, member 6, partial [Homo
sapiens]
Length = 182
Score = 80.1 bits (196), Expect = 8e-15
Identities = 56/180 (31%), Positives = 82/180 (45%), Gaps = 39/180 (21%)
Query: 417 EIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAF-------------------- 456
E K++W G ++Y+ + WN++DF M ++ A + AF
Sbjct: 4 ECKEIWTQGPKEYLFELWNMLDFGMLVIFTALFIARFRAFWHASKAQSIIDANDTLKDLT 63
Query: 457 -------VKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISL 509
VKY L RE W P +V+E L A+A + S + + AN GPLQ SL
Sbjct: 64 EVTLGDNVKYYNLARRE-WVPSDPWVVSEGLCAVAVVLSFSGIACILPANESFGPLQTSL 122
Query: 510 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQ 569
G + DI +F+ I+ +V +AF G+ LY YY KQN AF+TL L+
Sbjct: 123 GGAVKDIFRFMVIFIMVFVAFMIGMFNLYSYYIGA-----------KQNEAFTTLKRVLR 171
>gi|94538366 transient receptor potential cation channel, subfamily M,
member 1 [Homo sapiens]
Length = 1603
Score = 77.8 bits (190), Expect = 4e-14
Identities = 112/575 (19%), Positives = 233/575 (40%), Gaps = 142/575 (24%)
Query: 231 SKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEI--ILNYRDDNSLIEEQSGNDLAR 288
S + ++ + + S+ Q A +LLDQ+ E +L Y E ++ ++
Sbjct: 659 SDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMKLLTY-------ELKNWSNSTC 711
Query: 289 LKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIG--LLFPVFSV- 345
LKLA+ + ++F+A Q LL W R++ +K++ ++ +LF F
Sbjct: 712 LKLAVAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNPGLKVIMGILLPPTILFLEFRTY 769
Query: 346 ---CYLIAPKS----------------------------------PLGL----FIRKPFI 364
Y + ++ P+G F P +
Sbjct: 770 DDFSYQTSKENEDGKEKEEENTDANADAGSRKGDEENEHKKQRSIPIGTKICEFYNAPIV 829
Query: 365 KFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ--MW 422
KF +T SYL +L L L R P++ EW+++ +++ +I++ M
Sbjct: 830 KFWFYTISYLGYLLLFNYVI-------LVRMDGWPSLQEWIVISYIVSLALEKIREILMS 882
Query: 423 DGG-----LQDYIHDWWNLMDFVMNSLYL--ATISLKIVAFVKYSALNPRESWDMWHPTL 475
+ G ++ ++ ++WN+ D V S ++ A + L+ ++ Y +
Sbjct: 883 EPGKLSQKIKVWLQEYWNITDLVAISTFMIGAILRLQNQPYMGYGRV------------- 929
Query: 476 VAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLN 535
++ + IF +R++ +F N +LGP + +G+M++D+L F+ I +VL++F
Sbjct: 930 ----IYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSF----- 980
Query: 536 QLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFG-----LINLYVTNVK--- 587
G+ + I ++ ++ +W I+G I+LY +
Sbjct: 981 ----------GVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPC 1030
Query: 588 AQHEFTE------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIARRAADNL 635
++ + E ++ + Y +++ ++L+N+LIA+ NN++ + ++ +
Sbjct: 1031 GENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTF-FEVKSISNQV 1089
Query: 636 RRHHQYQEVMR----------NLVKRYVAAMI-----RDAKTEEGLTEENFKELKQDISS 680
+ +YQ +M ++ ++ +I R K EG EE + LK +S
Sbjct: 1090 WKFQRYQLIMTFHDRPVLPPPMIILSHIYIIIMRLSGRCRKKREGDQEERDRGLKLFLSD 1149
Query: 681 FRFEVLGLLRGSKLSTIQSANASKESSNSADSDEK 715
E L L + +Q KE + SDE+
Sbjct: 1150 ---EELKRLHEFEEQCVQEHFREKEDEQQSSSDER 1181
>gi|4507689 transient receptor potential cation channel, subfamily M,
member 2 [Homo sapiens]
Length = 1503
Score = 71.6 bits (174), Expect = 3e-12
Identities = 100/482 (20%), Positives = 181/482 (37%), Gaps = 94/482 (19%)
Query: 208 LIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEI 267
+I S+D A S L+ELSK E + S E L+ L + R + +
Sbjct: 640 IIWAQSQDCIAAALACSKILKELSKEEEDTDSSEEMLA----------LAEEYEHRAIGV 689
Query: 268 ILN-YRDDNSLIEE------QSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFP- 319
YR D ++ ++ L+LA++ + +FV+ Q L W+ +
Sbjct: 690 FTECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSV 749
Query: 320 --GWRRRHWAVKMVTCFIIGLL-FPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTF 376
G R + + GL+ F + + P + F P + F + SY F
Sbjct: 750 DNGLWRVTLCMLAFPLLLTGLISFREKRLQDVGTPAARARAFFTAPVVVFHLNILSYFAF 809
Query: 377 LFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMW----DGGLQD---- 428
L L ++ D P P+ E I W+ + E++Q++ + GL
Sbjct: 810 LCLFA----YVLMVDFQ---PVPSWCECAIYLWLFSLVCEEMRQLFYDPDECGLMKKAAL 862
Query: 429 YIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFS 488
Y D+WN +D L++A ++ +++ Y + ++ I
Sbjct: 863 YFSDFWNKLDVGAILLFVAGLTCRLIPATLYPG----------------RVILSLDFILF 906
Query: 489 SLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLT 548
LRL+ +FT + LGP I + RM+ D+ FLF+ + +++F + + E
Sbjct: 907 CLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDWL 966
Query: 549 CKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHE----------------- 591
+G + + +IFG I Y+ V E
Sbjct: 967 FRG---------------AVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCPES 1011
Query: 592 --------FTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIARRAAD--NLRRHHQY 641
F E++ + Y + + ++LLN+LIAM N ++Q + +RH
Sbjct: 1012 DATQQRPAFPEWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLI 1071
Query: 642 QE 643
+E
Sbjct: 1072 EE 1073
>gi|18921093 transient receptor potential cation channel, subfamily M,
member 6 [Homo sapiens]
Length = 2022
Score = 71.2 bits (173), Expect = 4e-12
Identities = 63/298 (21%), Positives = 123/298 (41%), Gaps = 48/298 (16%)
Query: 358 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
F P +KF +T +YL FL L L P P++ EW++ ++
Sbjct: 834 FYSAPIVKFWFYTMAYLAFLMLFTYTV-------LVEMQPQPSVQEWLVSIYIFTNAIEV 886
Query: 418 IKQM-------WDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
++++ + ++ +I ++WNL + V L+ A L+ W
Sbjct: 887 VREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLR---------------WGD 931
Query: 471 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
++ I IF RL+ F N H GP + +M ++ + I +VLL+F
Sbjct: 932 PPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSF 991
Query: 531 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLI---NLYVTNVK 587
G+ K I K+ ++S + + +W I+G + + V + +
Sbjct: 992 ---------------GVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQ 1036
Query: 588 AQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIARRAADNLRRHHQYQEVM 645
F+ + Y + ++++N+LIA NN Y L ++NL ++++Y+ +M
Sbjct: 1037 PSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVY-LDMESISNNLWKYNRYRYIM 1093
Score = 30.0 bits (66), Expect = 9.2
Identities = 27/108 (25%), Positives = 49/108 (45%), Gaps = 11/108 (10%)
Query: 231 SKVENEFKSEYEELSRQCKQFAKDLLDQT--RSSRELEIILNYRDDNSLIEEQSGNDLAR 288
S + ++ E + S+Q Q A DLL++ ++ R +L Y E ++ ++
Sbjct: 655 SHMVDDASEELKNYSKQFGQLALDLLEKAFKQNERMAMTLLTY-------ELRNWSNSTC 707
Query: 289 LKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFII 336
LKLA+ + FV+ Q LL W R+ W +K++ I+
Sbjct: 708 LKLAVSGGLRPFVSHTCTQMLLTDMWMGRLK-MRKNSW-LKIIISIIL 753
>gi|148612863 transient receptor potential cation channel, subfamily
M, member 7 [Homo sapiens]
Length = 1865
Score = 67.8 bits (164), Expect = 4e-11
Identities = 66/303 (21%), Positives = 133/303 (43%), Gaps = 45/303 (14%)
Query: 358 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
F P +KF +T +YL FL L L + P++ EW+++ ++ + +
Sbjct: 848 FYHAPIVKFWFNTLAYLGFLMLYTFVV-------LVQMEQLPSVQEWIVIAYIFTYAIEK 900
Query: 418 IKQMW---DGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSAL-NPRESWDMWHP 473
+++++ G + I W++ D+ S +A IS I +++ A N ++D H
Sbjct: 901 VREIFMSEAGKVNQKIKVWFS--DYFNISDTIAIISFFIGFGLRFGAKWNFANAYDN-HV 957
Query: 474 TLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANG 533
+ ++ + IF +RL+ N GP + +G+M+ ++ + I LVLL+F
Sbjct: 958 FVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSF--- 1014
Query: 534 LNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHE-- 591
G+ K I + +++ + + +W IFG + Y +V A
Sbjct: 1015 ------------GVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVI 1062
Query: 592 ---------FTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIARRAADNLRRHHQYQ 642
T F+ A Y + ++++N+LIA NN Y L + ++ + ++ +Y
Sbjct: 1063 PQICGPGTWLTPFLQA----VYLFVQYIIMVNLLIAFFNNVY-LQVKAISNIVWKYQRYH 1117
Query: 643 EVM 645
+M
Sbjct: 1118 FIM 1120
Score = 30.4 bits (67), Expect = 7.0
Identities = 26/98 (26%), Positives = 43/98 (43%), Gaps = 10/98 (10%)
Query: 231 SKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEI--ILNYRDDNSLIEEQSGNDLAR 288
S + ++ E ++ S Q A +LL+Q+ E +L Y E ++ ++
Sbjct: 669 SDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTY-------ELKNWSNSTC 721
Query: 289 LKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHW 326
LKLA+ R + FVA Q LL+ W R+ W
Sbjct: 722 LKLAVSSRLRPFVAHTCTQMLLSDMWMGRL-NMRKNSW 758
>gi|154091312 transient receptor potential cation channel, subfamily
M, member 3 isoform b [Homo sapiens]
Length = 1566
Score = 62.4 bits (150), Expect = 2e-09
Identities = 60/310 (19%), Positives = 135/310 (43%), Gaps = 60/310 (19%)
Query: 358 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
F P +KF +T +Y+ +L L +I + R P+ EW+++ ++ +
Sbjct: 724 FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 776
Query: 418 IKQ--MWDGG-----LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
+++ M + G ++ ++ ++WN+ D + L+ + L++ P S
Sbjct: 777 MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQD-------QPFRS--- 826
Query: 471 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
++ + I+ +RL+ +F N +LGP + +G+M++D++ F+ I +VL++F
Sbjct: 827 -----DGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 881
Query: 531 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL-YVTNVKAQ 589
+ F EE K I +W I+G + + Q
Sbjct: 882 GVARQAILFPNEEPSWKLAKNI---------------FYMPYWMIYGEVFADQIDPPCGQ 926
Query: 590 HEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIARRAADNL 635
+E E ++ + Y +++ ++L+N+LIA+ NN++ + ++ +
Sbjct: 927 NETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTF-FEVKSISNQV 985
Query: 636 RRHHQYQEVM 645
+ +YQ +M
Sbjct: 986 WKFQRYQLIM 995
Score = 32.0 bits (71), Expect = 2.4
Identities = 28/113 (24%), Positives = 49/113 (43%), Gaps = 23/113 (20%)
Query: 235 NEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLI------EEQSGNDLAR 288
++ E SR Q A +LLDQ+ Y+ D L E ++ ++
Sbjct: 546 DDISQELNHNSRDFGQLAVELLDQS-----------YKQDEQLAMKLLTYELKNWSNATC 594
Query: 289 LKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFP 341
L+LA+ + ++F+A Q LL W R++ +K+ I+G+L P
Sbjct: 595 LQLAVAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNSGLKV----ILGILLP 641
>gi|154091308 transient receptor potential cation channel, subfamily
M, member 3 isoform f [Homo sapiens]
Length = 1579
Score = 62.4 bits (150), Expect = 2e-09
Identities = 60/310 (19%), Positives = 135/310 (43%), Gaps = 60/310 (19%)
Query: 358 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
F P +KF +T +Y+ +L L +I + R P+ EW+++ ++ +
Sbjct: 737 FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 789
Query: 418 IKQ--MWDGG-----LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
+++ M + G ++ ++ ++WN+ D + L+ + L++ P S
Sbjct: 790 MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQD-------QPFRS--- 839
Query: 471 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
++ + I+ +RL+ +F N +LGP + +G+M++D++ F+ I +VL++F
Sbjct: 840 -----DGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 894
Query: 531 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL-YVTNVKAQ 589
+ F EE K I +W I+G + + Q
Sbjct: 895 GVARQAILFPNEEPSWKLAKNI---------------FYMPYWMIYGEVFADQIDPPCGQ 939
Query: 590 HEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIARRAADNL 635
+E E ++ + Y +++ ++L+N+LIA+ NN++ + ++ +
Sbjct: 940 NETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTF-FEVKSISNQV 998
Query: 636 RRHHQYQEVM 645
+ +YQ +M
Sbjct: 999 WKFQRYQLIM 1008
Score = 32.0 bits (71), Expect = 2.4
Identities = 28/113 (24%), Positives = 49/113 (43%), Gaps = 23/113 (20%)
Query: 235 NEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLI------EEQSGNDLAR 288
++ E SR Q A +LLDQ+ Y+ D L E ++ ++
Sbjct: 559 DDISQELNHNSRDFGQLAVELLDQS-----------YKQDEQLAMKLLTYELKNWSNATC 607
Query: 289 LKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFP 341
L+LA+ + ++F+A Q LL W R++ +K+ I+G+L P
Sbjct: 608 LQLAVAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNSGLKV----ILGILLP 654
>gi|154091310 transient receptor potential cation channel, subfamily
M, member 3 isoform g [Homo sapiens]
Length = 1569
Score = 62.4 bits (150), Expect = 2e-09
Identities = 60/310 (19%), Positives = 135/310 (43%), Gaps = 60/310 (19%)
Query: 358 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
F P +KF +T +Y+ +L L +I + R P+ EW+++ ++ +
Sbjct: 727 FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 779
Query: 418 IKQ--MWDGG-----LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
+++ M + G ++ ++ ++WN+ D + L+ + L++ P S
Sbjct: 780 MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQD-------QPFRS--- 829
Query: 471 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
++ + I+ +RL+ +F N +LGP + +G+M++D++ F+ I +VL++F
Sbjct: 830 -----DGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 884
Query: 531 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL-YVTNVKAQ 589
+ F EE K I +W I+G + + Q
Sbjct: 885 GVARQAILFPNEEPSWKLAKNI---------------FYMPYWMIYGEVFADQIDPPCGQ 929
Query: 590 HEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIARRAADNL 635
+E E ++ + Y +++ ++L+N+LIA+ NN++ + ++ +
Sbjct: 930 NETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTF-FEVKSISNQV 988
Query: 636 RRHHQYQEVM 645
+ +YQ +M
Sbjct: 989 WKFQRYQLIM 998
Score = 32.0 bits (71), Expect = 2.4
Identities = 28/113 (24%), Positives = 49/113 (43%), Gaps = 23/113 (20%)
Query: 235 NEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLI------EEQSGNDLAR 288
++ E SR Q A +LLDQ+ Y+ D L E ++ ++
Sbjct: 549 DDISQELNHNSRDFGQLAVELLDQS-----------YKQDEQLAMKLLTYELKNWSNATC 597
Query: 289 LKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFP 341
L+LA+ + ++F+A Q LL W R++ +K+ I+G+L P
Sbjct: 598 LQLAVAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNSGLKV----ILGILLP 644
>gi|154091320 transient receptor potential cation channel, subfamily
M, member 3 isoform a [Homo sapiens]
Length = 1554
Score = 62.4 bits (150), Expect = 2e-09
Identities = 60/310 (19%), Positives = 135/310 (43%), Gaps = 60/310 (19%)
Query: 358 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
F P +KF +T +Y+ +L L +I + R P+ EW+++ ++ +
Sbjct: 712 FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 764
Query: 418 IKQ--MWDGG-----LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
+++ M + G ++ ++ ++WN+ D + L+ + L++ P S
Sbjct: 765 MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQD-------QPFRS--- 814
Query: 471 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
++ + I+ +RL+ +F N +LGP + +G+M++D++ F+ I +VL++F
Sbjct: 815 -----DGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 869
Query: 531 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL-YVTNVKAQ 589
+ F EE K I +W I+G + + Q
Sbjct: 870 GVARQAILFPNEEPSWKLAKNI---------------FYMPYWMIYGEVFADQIDPPCGQ 914
Query: 590 HEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIARRAADNL 635
+E E ++ + Y +++ ++L+N+LIA+ NN++ + ++ +
Sbjct: 915 NETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTF-FEVKSISNQV 973
Query: 636 RRHHQYQEVM 645
+ +YQ +M
Sbjct: 974 WKFQRYQLIM 983
Score = 32.0 bits (71), Expect = 2.4
Identities = 28/113 (24%), Positives = 49/113 (43%), Gaps = 23/113 (20%)
Query: 235 NEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLI------EEQSGNDLAR 288
++ E SR Q A +LLDQ+ Y+ D L E ++ ++
Sbjct: 534 DDISQELNHNSRDFGQLAVELLDQS-----------YKQDEQLAMKLLTYELKNWSNATC 582
Query: 289 LKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFP 341
L+LA+ + ++F+A Q LL W R++ +K+ I+G+L P
Sbjct: 583 LQLAVAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNSGLKV----ILGILLP 629
>gi|154091318 transient receptor potential cation channel, subfamily
M, member 3 isoform d [Homo sapiens]
Length = 1544
Score = 62.4 bits (150), Expect = 2e-09
Identities = 60/310 (19%), Positives = 135/310 (43%), Gaps = 60/310 (19%)
Query: 358 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
F P +KF +T +Y+ +L L +I + R P+ EW+++ ++ +
Sbjct: 702 FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 754
Query: 418 IKQ--MWDGG-----LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
+++ M + G ++ ++ ++WN+ D + L+ + L++ P S
Sbjct: 755 MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQD-------QPFRS--- 804
Query: 471 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
++ + I+ +RL+ +F N +LGP + +G+M++D++ F+ I +VL++F
Sbjct: 805 -----DGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 859
Query: 531 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL-YVTNVKAQ 589
+ F EE K I +W I+G + + Q
Sbjct: 860 GVARQAILFPNEEPSWKLAKNI---------------FYMPYWMIYGEVFADQIDPPCGQ 904
Query: 590 HEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIARRAADNL 635
+E E ++ + Y +++ ++L+N+LIA+ NN++ + ++ +
Sbjct: 905 NETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTF-FEVKSISNQV 963
Query: 636 RRHHQYQEVM 645
+ +YQ +M
Sbjct: 964 WKFQRYQLIM 973
Score = 32.0 bits (71), Expect = 2.4
Identities = 28/113 (24%), Positives = 49/113 (43%), Gaps = 23/113 (20%)
Query: 235 NEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLI------EEQSGNDLAR 288
++ E SR Q A +LLDQ+ Y+ D L E ++ ++
Sbjct: 524 DDISQELNHNSRDFGQLAVELLDQS-----------YKQDEQLAMKLLTYELKNWSNATC 572
Query: 289 LKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFP 341
L+LA+ + ++F+A Q LL W R++ +K+ I+G+L P
Sbjct: 573 LQLAVAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNSGLKV----ILGILLP 619
>gi|154091316 transient receptor potential cation channel, subfamily
M, member 3 isoform e [Homo sapiens]
Length = 1556
Score = 62.4 bits (150), Expect = 2e-09
Identities = 60/310 (19%), Positives = 135/310 (43%), Gaps = 60/310 (19%)
Query: 358 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
F P +KF +T +Y+ +L L +I + R P+ EW+++ ++ +
Sbjct: 714 FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 766
Query: 418 IKQ--MWDGG-----LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
+++ M + G ++ ++ ++WN+ D + L+ + L++ P S
Sbjct: 767 MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQD-------QPFRS--- 816
Query: 471 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
++ + I+ +RL+ +F N +LGP + +G+M++D++ F+ I +VL++F
Sbjct: 817 -----DGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 871
Query: 531 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL-YVTNVKAQ 589
+ F EE K I +W I+G + + Q
Sbjct: 872 GVARQAILFPNEEPSWKLAKNI---------------FYMPYWMIYGEVFADQIDPPCGQ 916
Query: 590 HEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIARRAADNL 635
+E E ++ + Y +++ ++L+N+LIA+ NN++ + ++ +
Sbjct: 917 NETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTF-FEVKSISNQV 975
Query: 636 RRHHQYQEVM 645
+ +YQ +M
Sbjct: 976 WKFQRYQLIM 985
Score = 32.0 bits (71), Expect = 2.4
Identities = 28/113 (24%), Positives = 49/113 (43%), Gaps = 23/113 (20%)
Query: 235 NEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLI------EEQSGNDLAR 288
++ E SR Q A +LLDQ+ Y+ D L E ++ ++
Sbjct: 536 DDISQELNHNSRDFGQLAVELLDQS-----------YKQDEQLAMKLLTYELKNWSNATC 584
Query: 289 LKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFP 341
L+LA+ + ++F+A Q LL W R++ +K+ I+G+L P
Sbjct: 585 LQLAVAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNSGLKV----ILGILLP 631
>gi|154091314 transient receptor potential cation channel, subfamily
M, member 3 isoform k [Homo sapiens]
Length = 1707
Score = 62.4 bits (150), Expect = 2e-09
Identities = 60/310 (19%), Positives = 135/310 (43%), Gaps = 60/310 (19%)
Query: 358 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
F P +KF +T +Y+ +L L +I + R P+ EW+++ ++ +
Sbjct: 865 FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 917
Query: 418 IKQ--MWDGG-----LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
+++ M + G ++ ++ ++WN+ D + L+ + L++ P S
Sbjct: 918 MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQD-------QPFRS--- 967
Query: 471 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
++ + I+ +RL+ +F N +LGP + +G+M++D++ F+ I +VL++F
Sbjct: 968 -----DGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 1022
Query: 531 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL-YVTNVKAQ 589
+ F EE K I +W I+G + + Q
Sbjct: 1023 GVARQAILFPNEEPSWKLAKNI---------------FYMPYWMIYGEVFADQIDPPCGQ 1067
Query: 590 HEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIARRAADNL 635
+E E ++ + Y +++ ++L+N+LIA+ NN++ + ++ +
Sbjct: 1068 NETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTF-FEVKSISNQV 1126
Query: 636 RRHHQYQEVM 645
+ +YQ +M
Sbjct: 1127 WKFQRYQLIM 1136
Score = 32.0 bits (71), Expect = 2.4
Identities = 28/113 (24%), Positives = 49/113 (43%), Gaps = 23/113 (20%)
Query: 235 NEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLI------EEQSGNDLAR 288
++ E SR Q A +LLDQ+ Y+ D L E ++ ++
Sbjct: 687 DDISQELNHNSRDFGQLAVELLDQS-----------YKQDEQLAMKLLTYELKNWSNATC 735
Query: 289 LKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFP 341
L+LA+ + ++F+A Q LL W R++ +K+ I+G+L P
Sbjct: 736 LQLAVAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNSGLKV----ILGILLP 782
>gi|4505835 polycystin 2 [Homo sapiens]
Length = 968
Score = 50.4 bits (119), Expect = 7e-06
Identities = 60/268 (22%), Positives = 108/268 (40%), Gaps = 42/268 (15%)
Query: 429 YIHDWWNLMDFVMNSLYLATISLKI---------VAFVKYSALNPR-ESWDMWHPTLVAE 478
Y +WN +D V+ L + I + I + F++ P E W +
Sbjct: 502 YFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQFLEDQNTFPNFEHLAYWQ--IQFN 559
Query: 479 ALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLY 538
+ A+ F ++L N + L ++ R D+ F ++ ++ LA+A QL
Sbjct: 560 NIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYA----QLA 615
Query: 539 FYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGA 598
+ T Q + FST E + + F I G IN E +G
Sbjct: 616 YLVFGT------------QVDDFSTFQECIFTQFRIILGDINFAEIE-----EANRVLGP 658
Query: 599 TMFGTYNVISLVVLLNMLIAMMNNSY--------QLIARRAADNLRRHHQYQEVMRNLVK 650
F T+ +LLNM +A++N++Y Q A +L R ++ +++ +K
Sbjct: 659 IYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEMELSDLIRKGYHKALVKLKLK 718
Query: 651 RYVAAMIRDAKTEEGLTEENFKELKQDI 678
+ I ++ +G + NF EL+QD+
Sbjct: 719 KNTVDDISES-LRQGGGKLNFDELRQDL 745
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,093,345
Number of Sequences: 37866
Number of extensions: 1253320
Number of successful extensions: 5573
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 84
Number of HSP's successfully gapped in prelim test: 111
Number of HSP's that attempted gapping in prelim test: 5018
Number of HSP's gapped (non-prelim): 607
length of query: 828
length of database: 18,247,518
effective HSP length: 111
effective length of query: 717
effective length of database: 14,044,392
effective search space: 10069829064
effective search space used: 10069829064
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.