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Search of human proteins with 203097003
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
(1958 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] 3897 0.0
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 608 e-173
gi|188497642 ARHGAP15 [Homo sapiens] 172 4e-42
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens] 168 5e-41
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa... 139 4e-32
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap... 139 4e-32
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens] 134 1e-30
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens] 134 1e-30
gi|4757980 beta chimerin isoform 2 [Homo sapiens] 132 3e-30
gi|91106928 beta chimerin isoform 1 [Homo sapiens] 132 3e-30
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens] 118 5e-26
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens] 118 5e-26
gi|229094128 active breakpoint cluster region-related protein i... 115 5e-25
gi|38679957 active breakpoint cluster region-related protein is... 115 5e-25
gi|38679954 active breakpoint cluster region-related protein is... 115 5e-25
gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo ... 114 1e-24
gi|50843948 Rho GTPase activating protein 10 [Homo sapiens] 111 6e-24
gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b ... 111 6e-24
gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a ... 111 6e-24
gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo s... 111 8e-24
gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo sap... 107 1e-22
gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo sap... 107 1e-22
gi|4505507 oligophrenin 1 [Homo sapiens] 106 2e-22
gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo sapi... 106 3e-22
gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo sa... 105 4e-22
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 105 4e-22
gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens] 105 6e-22
gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo sa... 103 1e-21
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens] 103 1e-21
gi|208022687 GTPase regulator associated with the focal adhesion... 103 2e-21
>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
Length = 1958
Score = 3897 bits (10106), Expect = 0.0
Identities = 1958/1958 (100%), Positives = 1958/1958 (100%)
Query: 1 MMATRRTGLSEGDGDKLKACEVSKNKDGKEQSETVSLSEDETFSWPGPKTVTLKRTSQGF 60
MMATRRTGLSEGDGDKLKACEVSKNKDGKEQSETVSLSEDETFSWPGPKTVTLKRTSQGF
Sbjct: 1 MMATRRTGLSEGDGDKLKACEVSKNKDGKEQSETVSLSEDETFSWPGPKTVTLKRTSQGF 60
Query: 61 GFTLRHFIVYPPESAIQFSYKDEENGNRGGKQRNRLEPMDTIFVKQVKEGGPAFEAGLCT 120
GFTLRHFIVYPPESAIQFSYKDEENGNRGGKQRNRLEPMDTIFVKQVKEGGPAFEAGLCT
Sbjct: 61 GFTLRHFIVYPPESAIQFSYKDEENGNRGGKQRNRLEPMDTIFVKQVKEGGPAFEAGLCT 120
Query: 121 GDRIIKVNGESVIGKTYSQVIALIQNSDTTLELSVMPKDEDILQVLQFTKDVTALAYSQD 180
GDRIIKVNGESVIGKTYSQVIALIQNSDTTLELSVMPKDEDILQVLQFTKDVTALAYSQD
Sbjct: 121 GDRIIKVNGESVIGKTYSQVIALIQNSDTTLELSVMPKDEDILQVLQFTKDVTALAYSQD 180
Query: 181 AYLKGNEAYSGNARNIPEPPPICYPWLPSAPSAMAQPVEISPPDSSLSKQQTSTPVLTQP 240
AYLKGNEAYSGNARNIPEPPPICYPWLPSAPSAMAQPVEISPPDSSLSKQQTSTPVLTQP
Sbjct: 181 AYLKGNEAYSGNARNIPEPPPICYPWLPSAPSAMAQPVEISPPDSSLSKQQTSTPVLTQP 240
Query: 241 GRAYRMEIQVPPSPTDVAKSNTAVCVCNESVRTVIVPSEKVVDLLSNRNNHTGPSHRTEE 300
GRAYRMEIQVPPSPTDVAKSNTAVCVCNESVRTVIVPSEKVVDLLSNRNNHTGPSHRTEE
Sbjct: 241 GRAYRMEIQVPPSPTDVAKSNTAVCVCNESVRTVIVPSEKVVDLLSNRNNHTGPSHRTEE 300
Query: 301 VRYGVSEQTSLKTVSRTTSPPLSIPTTHLIHQPAGSRSLEPSGILLKSGNYSGHSDGISS 360
VRYGVSEQTSLKTVSRTTSPPLSIPTTHLIHQPAGSRSLEPSGILLKSGNYSGHSDGISS
Sbjct: 301 VRYGVSEQTSLKTVSRTTSPPLSIPTTHLIHQPAGSRSLEPSGILLKSGNYSGHSDGISS 360
Query: 361 SRSQAVEAPSVSVNHYSPNSHQHIDWKNYKTYKEYIDNRRLHIGCRTIQERLDSLRAASQ 420
SRSQAVEAPSVSVNHYSPNSHQHIDWKNYKTYKEYIDNRRLHIGCRTIQERLDSLRAASQ
Sbjct: 361 SRSQAVEAPSVSVNHYSPNSHQHIDWKNYKTYKEYIDNRRLHIGCRTIQERLDSLRAASQ 420
Query: 421 STTDYNQVVPNRTTLQGRRRSTSHDRVPQSVQIRQRSVSQERLEDSVLMKYCPRSASQGA 480
STTDYNQVVPNRTTLQGRRRSTSHDRVPQSVQIRQRSVSQERLEDSVLMKYCPRSASQGA
Sbjct: 421 STTDYNQVVPNRTTLQGRRRSTSHDRVPQSVQIRQRSVSQERLEDSVLMKYCPRSASQGA 480
Query: 481 LTSPSVSFSNHRTRSWDYIEGQDETLENVNSGTPIPDSNGEKKQTYKWSGFTEQDDRRGI 540
LTSPSVSFSNHRTRSWDYIEGQDETLENVNSGTPIPDSNGEKKQTYKWSGFTEQDDRRGI
Sbjct: 481 LTSPSVSFSNHRTRSWDYIEGQDETLENVNSGTPIPDSNGEKKQTYKWSGFTEQDDRRGI 540
Query: 541 CERPRQQEIHKSFRGSNFTVAPSVVNSDNRRMSGRGVGSVSQFKKIPPDLKTLQSNRNFQ 600
CERPRQQEIHKSFRGSNFTVAPSVVNSDNRRMSGRGVGSVSQFKKIPPDLKTLQSNRNFQ
Sbjct: 541 CERPRQQEIHKSFRGSNFTVAPSVVNSDNRRMSGRGVGSVSQFKKIPPDLKTLQSNRNFQ 600
Query: 601 TTCGMSLPRGISQDRSPLVKVRSNSLKAPSTHVTKPSFSQKSFVSIKDQRPVNHLHQNSL 660
TTCGMSLPRGISQDRSPLVKVRSNSLKAPSTHVTKPSFSQKSFVSIKDQRPVNHLHQNSL
Sbjct: 601 TTCGMSLPRGISQDRSPLVKVRSNSLKAPSTHVTKPSFSQKSFVSIKDQRPVNHLHQNSL 660
Query: 661 LNQQTWVRTDSAPDQQVETGKSPSLSGASAKPAPQSSENAGTSDLELPVSQRNQDLSLQE 720
LNQQTWVRTDSAPDQQVETGKSPSLSGASAKPAPQSSENAGTSDLELPVSQRNQDLSLQE
Sbjct: 661 LNQQTWVRTDSAPDQQVETGKSPSLSGASAKPAPQSSENAGTSDLELPVSQRNQDLSLQE 720
Query: 721 AETEQSDTLDNKEAVILREKPPSGRQTPQPLRHQSYILAVNDQETGSDTTCWLPNDARRE 780
AETEQSDTLDNKEAVILREKPPSGRQTPQPLRHQSYILAVNDQETGSDTTCWLPNDARRE
Sbjct: 721 AETEQSDTLDNKEAVILREKPPSGRQTPQPLRHQSYILAVNDQETGSDTTCWLPNDARRE 780
Query: 781 VHIKRMEERKASSTSPPGDSLASIPFIDEPTSPSIDHDIAHIPASAVISASTSQVPSIAT 840
VHIKRMEERKASSTSPPGDSLASIPFIDEPTSPSIDHDIAHIPASAVISASTSQVPSIAT
Sbjct: 781 VHIKRMEERKASSTSPPGDSLASIPFIDEPTSPSIDHDIAHIPASAVISASTSQVPSIAT 840
Query: 841 VPPCLTTSAPLIRRQLSHDHESVGPPSLDAQPNSKTERSKSYDEGLDDYREDAKLSFKHV 900
VPPCLTTSAPLIRRQLSHDHESVGPPSLDAQPNSKTERSKSYDEGLDDYREDAKLSFKHV
Sbjct: 841 VPPCLTTSAPLIRRQLSHDHESVGPPSLDAQPNSKTERSKSYDEGLDDYREDAKLSFKHV 900
Query: 901 SSLKGIKIADSQKSSEDSGSRKDSSSEVFSDAAKEGWLHFRPLVTDKGKRVGGSIRPWKQ 960
SSLKGIKIADSQKSSEDSGSRKDSSSEVFSDAAKEGWLHFRPLVTDKGKRVGGSIRPWKQ
Sbjct: 901 SSLKGIKIADSQKSSEDSGSRKDSSSEVFSDAAKEGWLHFRPLVTDKGKRVGGSIRPWKQ 960
Query: 961 MYVVLRGHSLYLYKDKREQTTPSEEEQPISVNACLIDISYSETKRKNVFRLTTSDCECLF 1020
MYVVLRGHSLYLYKDKREQTTPSEEEQPISVNACLIDISYSETKRKNVFRLTTSDCECLF
Sbjct: 961 MYVVLRGHSLYLYKDKREQTTPSEEEQPISVNACLIDISYSETKRKNVFRLTTSDCECLF 1020
Query: 1021 QAEDRDDMLAWIKTIQESSNLNEEDTGVTNRDLISRRIKEYNNLMSKAEQLPKTPRQSLS 1080
QAEDRDDMLAWIKTIQESSNLNEEDTGVTNRDLISRRIKEYNNLMSKAEQLPKTPRQSLS
Sbjct: 1021 QAEDRDDMLAWIKTIQESSNLNEEDTGVTNRDLISRRIKEYNNLMSKAEQLPKTPRQSLS 1080
Query: 1081 IRQTLLGAKSEPKTQSPHSPKEESERKLLSKDDTSPPKDKGTWRKGIPSIMRKTFEKKPT 1140
IRQTLLGAKSEPKTQSPHSPKEESERKLLSKDDTSPPKDKGTWRKGIPSIMRKTFEKKPT
Sbjct: 1081 IRQTLLGAKSEPKTQSPHSPKEESERKLLSKDDTSPPKDKGTWRKGIPSIMRKTFEKKPT 1140
Query: 1141 ATGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELN 1200
ATGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELN
Sbjct: 1141 ATGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELN 1200
Query: 1201 KGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLK 1260
KGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLK
Sbjct: 1201 KGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLK 1260
Query: 1261 RLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTH 1320
RLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTH
Sbjct: 1261 RLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTH 1320
Query: 1321 MPDQYKIVETLIQHHDWFFTEEGAEEPLTTVQEESTVDSQPVPNIDHLLTNIGRTGVSPG 1380
MPDQYKIVETLIQHHDWFFTEEGAEEPLTTVQEESTVDSQPVPNIDHLLTNIGRTGVSPG
Sbjct: 1321 MPDQYKIVETLIQHHDWFFTEEGAEEPLTTVQEESTVDSQPVPNIDHLLTNIGRTGVSPG 1380
Query: 1381 DVSDSATSDSTKSKGSWGSGKDQYSRELLVSSIFAAASRKRKKPKEKAQPSSSEDELDNV 1440
DVSDSATSDSTKSKGSWGSGKDQYSRELLVSSIFAAASRKRKKPKEKAQPSSSEDELDNV
Sbjct: 1381 DVSDSATSDSTKSKGSWGSGKDQYSRELLVSSIFAAASRKRKKPKEKAQPSSSEDELDNV 1440
Query: 1441 FFKKENVEQCHNDTKEESKKESETLGRKQKIIIAKENSTRKDPSTTKDEKISLGKESTPS 1500
FFKKENVEQCHNDTKEESKKESETLGRKQKIIIAKENSTRKDPSTTKDEKISLGKESTPS
Sbjct: 1441 FFKKENVEQCHNDTKEESKKESETLGRKQKIIIAKENSTRKDPSTTKDEKISLGKESTPS 1500
Query: 1501 EEPSPPHNSKHNKSPTLSCRFAILKESPRSLLAQKSSHLEETGSDSGTLLSTSSQASLAR 1560
EEPSPPHNSKHNKSPTLSCRFAILKESPRSLLAQKSSHLEETGSDSGTLLSTSSQASLAR
Sbjct: 1501 EEPSPPHNSKHNKSPTLSCRFAILKESPRSLLAQKSSHLEETGSDSGTLLSTSSQASLAR 1560
Query: 1561 FSMKKSTSPETKHSEFLANVSTITSDYSTTSSATYLTSLDSSRLSPEVQSVAESKGDEAD 1620
FSMKKSTSPETKHSEFLANVSTITSDYSTTSSATYLTSLDSSRLSPEVQSVAESKGDEAD
Sbjct: 1561 FSMKKSTSPETKHSEFLANVSTITSDYSTTSSATYLTSLDSSRLSPEVQSVAESKGDEAD 1620
Query: 1621 DERSELISEGRPVETDSESEFPVFPTALTSERLFRGKLQEVTKSSRRNSEGSELSCTEGS 1680
DERSELISEGRPVETDSESEFPVFPTALTSERLFRGKLQEVTKSSRRNSEGSELSCTEGS
Sbjct: 1621 DERSELISEGRPVETDSESEFPVFPTALTSERLFRGKLQEVTKSSRRNSEGSELSCTEGS 1680
Query: 1681 LTSSLDSRRQLFSSHKLIECDTLSRKKSARFKSDSGSLGDAKNEKEAPSLTKVFDVMKKG 1740
LTSSLDSRRQLFSSHKLIECDTLSRKKSARFKSDSGSLGDAKNEKEAPSLTKVFDVMKKG
Sbjct: 1681 LTSSLDSRRQLFSSHKLIECDTLSRKKSARFKSDSGSLGDAKNEKEAPSLTKVFDVMKKG 1740
Query: 1741 KSTGSLLTPTRGESEKQEPTWKTKIADRLKLRPRAPADDMFGVGNHKVNAETAKRKSIRR 1800
KSTGSLLTPTRGESEKQEPTWKTKIADRLKLRPRAPADDMFGVGNHKVNAETAKRKSIRR
Sbjct: 1741 KSTGSLLTPTRGESEKQEPTWKTKIADRLKLRPRAPADDMFGVGNHKVNAETAKRKSIRR 1800
Query: 1801 RHTLGGHRDATEISVLNFWKVHEQSGERESELSAVNRLKPKCSAQDLSISDWLARERLRT 1860
RHTLGGHRDATEISVLNFWKVHEQSGERESELSAVNRLKPKCSAQDLSISDWLARERLRT
Sbjct: 1801 RHTLGGHRDATEISVLNFWKVHEQSGERESELSAVNRLKPKCSAQDLSISDWLARERLRT 1860
Query: 1861 STSDLSRGEIGDPQTENPSTREIATTDTPLSLHCNTGSSSSTLASTNRPLLSIPPQSPDQ 1920
STSDLSRGEIGDPQTENPSTREIATTDTPLSLHCNTGSSSSTLASTNRPLLSIPPQSPDQ
Sbjct: 1861 STSDLSRGEIGDPQTENPSTREIATTDTPLSLHCNTGSSSSTLASTNRPLLSIPPQSPDQ 1920
Query: 1921 INGESFQNVSKNASSAANAQPHKLSETPGSKAEFHPCL 1958
INGESFQNVSKNASSAANAQPHKLSETPGSKAEFHPCL
Sbjct: 1921 INGESFQNVSKNASSAANAQPHKLSETPGSKAEFHPCL 1958
>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
Length = 1397
Score = 608 bits (1569), Expect = e-173
Identities = 359/745 (48%), Positives = 471/745 (63%), Gaps = 75/745 (10%)
Query: 730 DNKEAVILREKPPSGRQTP-QPLRHQSYILAVNDQETGSDTTCWLPNDARREVHIKRMEE 788
D + V+LR+KPP+GR+ P R + L D+ P + R + R
Sbjct: 390 DRGDEVVLRQKPPTGRKVQLTPARQMN--LGFGDESPE-------PEASGRGERLGR--- 437
Query: 789 RKASSTSPPGDSLASIPFIDEPTSPSIDHDIAHIPASAVISASTSQVPSIATVPPCLTTS 848
K + + DSLASIPFIDEPTSPSID H+PASAV+S++ + P + T P T +
Sbjct: 438 -KVAPLATTEDSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFT 496
Query: 849 APLIRRQLSHDHESVGPPSLDAQPNSK------TERSKSYDEGLDDYREDAKLSFKHVSS 902
L R H S S+ A S TERSKS D+GL+ +R++ ++ + +
Sbjct: 497 FTLGR------HYSQDCSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNR 550
Query: 903 LKGIKIA---------DSQKSSEDSG------SRKDSSSEVFSDAAKEGWLHFRPLVTDK 947
+ +++ DS +SED+ S D S FSD +EGWL+++ ++T K
Sbjct: 551 IPSLRMLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKK 610
Query: 948 GKRVGGSIRPWKQMYVVLRGHSLYLYKDKREQTTPS----------EEEQPISVNACLID 997
GK+ G +R WK++Y LR SL L K++RE + +E P+ + +CL+D
Sbjct: 611 GKKAGSGLRQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVD 670
Query: 998 ISYSETKRKNVFRLTTSD-CECLFQAEDRDDMLAWIKTIQESSNLNEEDTGVTNRDLISR 1056
ISYSETKR++VFRLTT+D CE LFQAEDRDDML WI+ I+E+S ED G N+ LIS+
Sbjct: 671 ISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISK 730
Query: 1057 RIKEYNNLMS----KAEQLPKTPRQSLSIRQTLLGAKSEPKTQSPHSPKEESERKLLSKD 1112
++ +Y + KA+ PK R L G KSE QS + SKD
Sbjct: 731 KLNDYRKVSHSSGPKADSSPKGSRG-------LGGLKSEFLKQSAARGLRTQDLPAGSKD 783
Query: 1113 DTSPPKDKGTWRKGIPSIMRKTFEKKPTATGTFGVRLDDCPPAHTNRYIPLIVDICCKLV 1172
D S K W GI +I++K + P A FGVRL++C PA N+ +PLIV CC++V
Sbjct: 784 D-SAAAPKTPW--GI-NIIKKNKKAAPRA---FGVRLEECQPATENQRVPLIVAACCRIV 836
Query: 1173 EERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPE 1232
E RGLE TGIYRVPGNNA +SS+QE+LN+G DI++QD++W+DLNVISSLLKSFFRKLPE
Sbjct: 837 EARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPE 896
Query: 1233 PLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVAENSEKNK 1292
PLFT+DKY DFIEANR ED +R++TL++LI DLP H+YETLKFL HLKT+A++SEKNK
Sbjct: 897 PLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNK 956
Query: 1293 MEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFFTEEGAEEPLTTVQ 1352
MEPRNLA+VFGPTLVRTSEDNMT MVTHMPD+YKIVETLIQH DWFF++E + T V
Sbjct: 957 MEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFSDEEDKGERTPVG 1016
Query: 1353 EESTVDSQPVPNIDHLLTNIGRTGVSPGDV-SDSATSDSTKSKGSWGSGKDQYSRELLVS 1411
++ + Q VPNI++LL NIGRT V PGD SDS T S KSKGSW K+ Y+RE+L
Sbjct: 1017 DK---EPQAVPNIEYLLPNIGRT-VPPGDPGSDSTTCSSAKSKGSWAPKKEPYAREMLAI 1072
Query: 1412 SIFAAASRKRKKPKEKAQPSSSEDE 1436
S +A +RKRKK +E SS D+
Sbjct: 1073 SFISAVNRKRKKRREARGLGSSTDD 1097
Score = 176 bits (446), Expect = 2e-43
Identities = 98/157 (62%), Positives = 109/157 (69%), Gaps = 18/157 (11%)
Query: 99 MDTIFVKQVKEGGPAFEAGLCTGDRIIKVNGESVIGKTYSQVIALIQNSDTTLELSVMPK 158
MDTIFVK VKE GPA AGL TGDR++KVNGESVIGKTYSQVIALIQNSD TLELS+MPK
Sbjct: 1 MDTIFVKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPK 60
Query: 159 DEDILQVLQFTKDVTALAYSQDAYLKGNEAYSGNARNIPEPPPICYPWLPSAPSAMA--Q 216
DEDILQ LAYSQDAYLKGNE YSG AR+IPEPPPICYP AP A A +
Sbjct: 61 DEDILQ----------LAYSQDAYLKGNEPYSGEARSIPEPPPICYPRKTYAPPARASTR 110
Query: 217 PVEISPPDSSLSKQQTSTPVLTQPGRAYRMEIQVPPS 253
+ P S+L S + PG ++VPP+
Sbjct: 111 ATMVPEPTSALPSDPRSPAAWSDPG------LRVPPA 141
Score = 62.8 bits (151), Expect = 3e-09
Identities = 83/302 (27%), Positives = 117/302 (38%), Gaps = 64/302 (21%)
Query: 1578 ANVSTITSDYSTTSSATYLTSLDSSRLSPEVQSVAESKGDEADDERSELISEGRPVETDS 1637
A+ +I S YST L+++D S S A + GDEADDERSEL VETD+
Sbjct: 1147 ADTRSIVSGYST------LSTMDRSVCSGASGRRAGA-GDEADDERSELSH----VETDT 1195
Query: 1638 ESEFPVFPTALTSERLFRGKLQEVTKSSRRNSEGSELSCTEGSLTSSLDSRRQLFSSHKL 1697
E P G LT RR FSSH L
Sbjct: 1196 EGAAGAGPG--------------------------------GRLT-----RRPSFSSHHL 1218
Query: 1698 IECDTLSRKKSARFKSDSGSLGDAKNEKEAPSLTKVFDVMKKGKSTGSLLTPTRGESEKQ 1757
+ CDTL+R++ AR + D G P + S SL P + +
Sbjct: 1219 MPCDTLARRRLARGRPDGEGAGRGGPRAPEPPGS------ASSSSQESLRPPAAALASRP 1272
Query: 1758 EPTWKTKIADRLKLRPRAPADDMFGVG-NHKVNAETAKRKSIRRRHTLGGHRDATEISVL 1816
+ L+LR R ADDM V ++ ET +R+S RRHT+ T+++
Sbjct: 1273 SR------MEALRLRLRGTADDMLAVRLRRPLSPETRRRRSSWRRHTVVVQSPLTDLN-F 1325
Query: 1817 NFWKVHEQSGERESELSAVNRLKPKCSAQDLSISDWLARERLRTSTSDLSRGEIGDPQTE 1876
N WK E G E + + S+ AR ++ + G+ G Q++
Sbjct: 1326 NEWK--ELGGGGPPEPAGARAHSDNKDSGLSSLESTKARAPSSAASQPPAPGDTGSLQSQ 1383
Query: 1877 NP 1878
P
Sbjct: 1384 PP 1385
Score = 33.5 bits (75), Expect = 2.1
Identities = 34/109 (31%), Positives = 47/109 (43%), Gaps = 14/109 (12%)
Query: 404 GCRTIQERLDSLRAASQSTTDYNQVVPNRTTLQGRRRSTSHDRVPQSVQIRQRSVSQERL 463
G R RL+ +A S ++ VP R G RR + + R RS SQ+RL
Sbjct: 180 GSRVPPSRLECQQALSHWLSNQ---VPRRA---GERRCPA-------MAPRARSASQDRL 226
Query: 464 EDSVLMKYCPRSASQGALTSPSVSFSNHRTRSWDYIEGQDETLENVNSG 512
E+ + P S SQ AL+ HR RS DY+ + E + G
Sbjct: 227 EEVAAPRPWPCSTSQDALSQLGQE-GWHRARSDDYLSRATRSAEALGPG 274
>gi|188497642 ARHGAP15 [Homo sapiens]
Length = 475
Score = 172 bits (435), Expect = 4e-42
Identities = 142/472 (30%), Positives = 231/472 (48%), Gaps = 47/472 (9%)
Query: 891 EDAKLSFKHVSSLKGIKIADSQKSSED-SGSRKDSSSEVFSDAA---------KEGWLHF 940
++A +S K + + D K +E S R++ S + D KEG+L
Sbjct: 29 KNANSHHDRLSQSKSMILTDVGKVTEPISRHRRNHSQHILKDVIPPLEQLMVEKEGYLQ- 87
Query: 941 RPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYLYKDKREQTTPSEE--EQPISVNACLIDI 998
+ + D GK++ + W ++VL + YK+ ++Q + + +P SV+ C I
Sbjct: 88 KAKIADGGKKLR---KNWSTSWIVLSSRRIEFYKESKQQALSNMKTGHKPESVDLCGAHI 144
Query: 999 SYSETK--RKNVFRLTT-SDCECLFQAEDRDDMLAWIKTIQESSNLNEEDTGVTNRDLIS 1055
+++ K RKNVF++TT S E L Q++ +L W I+ + + +D+ +R+L
Sbjct: 145 EWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDWFHAIKNAIDRLPKDSSCPSRNL-- 202
Query: 1056 RRIKEYNNLMSKAEQLPKTPRQSLSIRQTLLGAKSEPKTQSPHSPKEESERKLLSKDDTS 1115
+L K R S + + L S+ K Q P K R S DTS
Sbjct: 203 --------------ELFKIQRSSST--ELLSHYDSDIKEQKPEHRKSLMFRLHHSASDTS 246
Query: 1116 PP-KDKGTWRKGI---PSIMRKTFEKKPTATGT-FGVRLDDCPPAHTNRYIPLIVDICCK 1170
+ K +K I PS+ KT ++K FG L N +P V C +
Sbjct: 247 DKNRVKSRLKKFITRRPSL--KTLQEKGLIKDQIFGSHLHKVCERE-NSTVPWFVKQCIE 303
Query: 1171 LVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKL 1230
VE+RGL+ GIYRV GN A I ++ +N+ +++ D +W D++V++ LK FFR+L
Sbjct: 304 AVEKRGLDVDGIYRVSGNLATIQKLRFIVNQE-EKLNLDDSQWEDIHVVTGALKMFFREL 362
Query: 1231 PEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVAENSEK 1290
PEPLF + F+EA +K+D R++ +K L+ LP + +T+K L HL + + K
Sbjct: 363 PEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASK 422
Query: 1291 NKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFFTEE 1342
N M ++L IVFGPTL+R +E+ +M HM Q +I E ++ + F E
Sbjct: 423 NLMSTQSLGIVFGPTLLR-AENETGNMAIHMVYQNQIAELMLSEYSKIFGSE 473
>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
Length = 846
Score = 168 bits (425), Expect = 5e-41
Identities = 131/431 (30%), Positives = 209/431 (48%), Gaps = 50/431 (11%)
Query: 913 KSSEDSGSRKDSSSEVFSDAAKEGWLHFRPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYL 972
+SS S +D++S D K G L+ + + GK+V + W + VL+G SL
Sbjct: 446 ESSPSSPKHQDTASSP-KDQEKYGLLNVTK-IAENGKKVR---KNWLSSWAVLQGSSLLF 500
Query: 973 YKDKREQTT-----PSEEEQPISVNACLIDI-SYSETKRKNVFRLTTSD-CECLFQAEDR 1025
K + T+ S+ E + + I++ S ++ +KNVF L T E L Q+++
Sbjct: 501 TKTQGSSTSWFGSNQSKPEFTVDLKGATIEMASKDKSSKKNVFELKTRQGTELLIQSDND 560
Query: 1026 DDMLAWIKTIQESSNLN--EEDTGVTNRDLISRRIKEYNNLMSKAEQLPKTPRQSLSIRQ 1083
+ W K + + N E D G+ E++P +P
Sbjct: 561 TVINDWFKVLSSTINNQAVETDEGIE-------------------EEIPDSP-------- 593
Query: 1084 TLLGAKSEPKTQSPHSPKEESERKLLSKDDTSPPKDKGTWRKGIPS--IMRKTFEKKPTA 1141
G + K + PK+ K+ S D + K K +K + ++ EK
Sbjct: 594 ---GIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIK 650
Query: 1142 TGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNK 1201
FG L + N +P V +C + VEE GL+ GIYRV GN A I ++ +N
Sbjct: 651 DQVFGSNLANLCQRE-NGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNH 709
Query: 1202 GMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKR 1261
+D+ D KW D++VI+ LK FFR+LPEPLFT + + DF+ A K++P R+ +K
Sbjct: 710 D-EKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAI-KQEPRQRVAAVKD 767
Query: 1262 LIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHM 1321
LI LP+ + +T++ L HL+ V EN EKN+M +++AIVFGPTL++ E ++ H
Sbjct: 768 LIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLK-PEKETGNIAVHT 826
Query: 1322 PDQYKIVETLI 1332
Q +IVE ++
Sbjct: 827 VYQNQIVELIL 837
>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
sapiens]
Length = 521
Score = 139 bits (349), Expect = 4e-32
Identities = 121/411 (29%), Positives = 185/411 (45%), Gaps = 40/411 (9%)
Query: 934 KEGWLHFRPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYLYKDKREQTT-----PSEEEQP 988
K G LH R DKGKR+ + W + VL G L +KD + PS+ P
Sbjct: 131 KAGVLH-RTKTADKGKRLRK--KHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTP 187
Query: 989 ISV----NACLIDISYSETKRKNVFRLTTSD-CECLFQAEDRDDMLAWIKTIQESSNLNE 1043
A L ++ RKNV L + D E L Q + + W K I + + E
Sbjct: 188 EYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQG--IQE 245
Query: 1044 EDTGVTNRDLISRRIKEYNNLMSKAEQLPKTPRQSLSIRQTLLGAKSEPK-TQSPHSPKE 1102
+ + S R+ +E+L + R P +S S
Sbjct: 246 LSAELPPEESESSRVD-----FGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVR 300
Query: 1103 ESERKLLSKDDTSPPKDKGTWRKGIPSIMRKTFEKKPTATGTFGVRLDDCPPAHTNRYIP 1162
RK L + T + S+ K + K FG L +R +P
Sbjct: 301 HKLRKFLQRRPT------------LQSLREKGYIKDQV----FGCALAALCERERSR-VP 343
Query: 1163 LIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISSL 1222
V C + VE RGL+ G+YR+ GN A I ++ +++ +D+ D +W D++VI+
Sbjct: 344 RFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDER-LDLDDGRWEDVHVITGA 402
Query: 1223 LKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHLK 1282
LK FFR+LPEPLF + FI A + +D R + ++ L+ LP +++TL+ L HL
Sbjct: 403 LKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLC 462
Query: 1283 TVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQ 1333
V E+ E+N+M +++AIVFGPTL+R E T M M Q ++VE ++Q
Sbjct: 463 RVIEHGEQNRMSVQSVAIVFGPTLLR-PEVEETSMPMTMVFQNQVVELILQ 512
>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sapiens]
Length = 548
Score = 139 bits (349), Expect = 4e-32
Identities = 121/411 (29%), Positives = 185/411 (45%), Gaps = 40/411 (9%)
Query: 934 KEGWLHFRPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYLYKDKREQTT-----PSEEEQP 988
K G LH R DKGKR+ + W + VL G L +KD + PS+ P
Sbjct: 158 KAGVLH-RTKTADKGKRLRK--KHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTP 214
Query: 989 ISV----NACLIDISYSETKRKNVFRLTTSD-CECLFQAEDRDDMLAWIKTIQESSNLNE 1043
A L ++ RKNV L + D E L Q + + W K I + + E
Sbjct: 215 EYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQG--IQE 272
Query: 1044 EDTGVTNRDLISRRIKEYNNLMSKAEQLPKTPRQSLSIRQTLLGAKSEPK-TQSPHSPKE 1102
+ + S R+ +E+L + R P +S S
Sbjct: 273 LSAELPPEESESSRVD-----FGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVR 327
Query: 1103 ESERKLLSKDDTSPPKDKGTWRKGIPSIMRKTFEKKPTATGTFGVRLDDCPPAHTNRYIP 1162
RK L + T + S+ K + K FG L +R +P
Sbjct: 328 HKLRKFLQRRPT------------LQSLREKGYIKDQV----FGCALAALCERERSR-VP 370
Query: 1163 LIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISSL 1222
V C + VE RGL+ G+YR+ GN A I ++ +++ +D+ D +W D++VI+
Sbjct: 371 RFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDER-LDLDDGRWEDVHVITGA 429
Query: 1223 LKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHLK 1282
LK FFR+LPEPLF + FI A + +D R + ++ L+ LP +++TL+ L HL
Sbjct: 430 LKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLC 489
Query: 1283 TVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQ 1333
V E+ E+N+M +++AIVFGPTL+R E T M M Q ++VE ++Q
Sbjct: 490 RVIEHGEQNRMSVQSVAIVFGPTLLR-PEVEETSMPMTMVFQNQVVELILQ 539
>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
Length = 459
Score = 134 bits (336), Expect = 1e-30
Identities = 73/185 (39%), Positives = 110/185 (59%), Gaps = 1/185 (0%)
Query: 1155 AHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWR 1214
AHT + P++VD+C + +E RGL G+YRV G + I ++ ++ DI + +
Sbjct: 276 AHTTKR-PMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYE 334
Query: 1215 DLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETL 1274
D+N+I+ LK +FR LP PL T D Y FIE+ + DP ++L+TL + LP H ETL
Sbjct: 335 DINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETL 394
Query: 1275 KFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQH 1334
++L AHLK V + ++N M NL IVFGPTL+R+ E + + + Q +VE LI++
Sbjct: 395 RYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKN 454
Query: 1335 HDWFF 1339
D F
Sbjct: 455 EDILF 459
>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
Length = 433
Score = 134 bits (336), Expect = 1e-30
Identities = 73/185 (39%), Positives = 110/185 (59%), Gaps = 1/185 (0%)
Query: 1155 AHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWR 1214
AHT + P++VD+C + +E RGL G+YRV G + I ++ ++ DI + +
Sbjct: 250 AHTTKR-PMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYE 308
Query: 1215 DLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETL 1274
D+N+I+ LK +FR LP PL T D Y FIE+ + DP ++L+TL + LP H ETL
Sbjct: 309 DINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETL 368
Query: 1275 KFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQH 1334
++L AHLK V + ++N M NL IVFGPTL+R+ E + + + Q +VE LI++
Sbjct: 369 RYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKN 428
Query: 1335 HDWFF 1339
D F
Sbjct: 429 EDILF 433
>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
Length = 468
Score = 132 bits (333), Expect = 3e-30
Identities = 71/182 (39%), Positives = 106/182 (58%)
Query: 1158 NRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLN 1217
N P++VDIC + +E RGL+ G+YRV G I ++ ++ DI + + D+N
Sbjct: 287 NTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDIN 346
Query: 1218 VISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFL 1277
+I+ LK +FR LP P+ T D Y+ FI+A + + +RL+ + ++ LP HYETL++L
Sbjct: 347 IITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYL 406
Query: 1278 SAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDW 1337
HLK V N + N M NL IVFGPTL+R ED+ + M Q IV+ LI++ D
Sbjct: 407 MIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDV 466
Query: 1338 FF 1339
F
Sbjct: 467 LF 468
>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
Length = 332
Score = 132 bits (333), Expect = 3e-30
Identities = 71/182 (39%), Positives = 106/182 (58%)
Query: 1158 NRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLN 1217
N P++VDIC + +E RGL+ G+YRV G I ++ ++ DI + + D+N
Sbjct: 151 NTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDIN 210
Query: 1218 VISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFL 1277
+I+ LK +FR LP P+ T D Y+ FI+A + + +RL+ + ++ LP HYETL++L
Sbjct: 211 IITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYL 270
Query: 1278 SAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDW 1337
HLK V N + N M NL IVFGPTL+R ED+ + M Q IV+ LI++ D
Sbjct: 271 MIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDV 330
Query: 1338 FF 1339
F
Sbjct: 331 LF 332
>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
Length = 1227
Score = 118 bits (296), Expect = 5e-26
Identities = 68/170 (40%), Positives = 96/170 (56%), Gaps = 2/170 (1%)
Query: 1142 TGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNK 1201
TG FGV++ ++ +P IV C + +E RG+E GIYRV G I +++ +
Sbjct: 1005 TGVFGVKIAVVTKRERSK-VPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDV 1063
Query: 1202 GMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKR 1261
D+ + + D+N I+ LK +FR+LPEPLFT++ Y +F E DP+ + +
Sbjct: 1064 NNKDVSVMMSEM-DVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLN 1122
Query: 1262 LIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSE 1311
L+ LPE + T FL HLK VAE NKM NLA VFGPTL+R SE
Sbjct: 1123 LLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSE 1172
>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
Length = 1271
Score = 118 bits (296), Expect = 5e-26
Identities = 68/170 (40%), Positives = 96/170 (56%), Gaps = 2/170 (1%)
Query: 1142 TGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNK 1201
TG FGV++ ++ +P IV C + +E RG+E GIYRV G I +++ +
Sbjct: 1049 TGVFGVKIAVVTKRERSK-VPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDV 1107
Query: 1202 GMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKR 1261
D+ + + D+N I+ LK +FR+LPEPLFT++ Y +F E DP+ + +
Sbjct: 1108 NNKDVSVMMSEM-DVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLN 1166
Query: 1262 LIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSE 1311
L+ LPE + T FL HLK VAE NKM NLA VFGPTL+R SE
Sbjct: 1167 LLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSE 1216
>gi|229094128 active breakpoint cluster region-related protein
isoform c [Homo sapiens]
Length = 813
Score = 115 bits (287), Expect = 5e-25
Identities = 77/219 (35%), Positives = 111/219 (50%), Gaps = 12/219 (5%)
Query: 1131 MRKTFEKKPTATGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNA 1190
+++T KK T G FGV++ ++ +P IV C + VE+RG+E GIYR+ G
Sbjct: 587 LKRTPSKKQT--GVFGVKISVVTKRERSK-VPYIVRQCVEEVEKRGIEEVGIYRISGVAT 643
Query: 1191 AISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKE 1250
I +++ + DI + D+N I+ LK +FR+LPEPL T+ Y F+E
Sbjct: 644 DIQALKAVFDANNKDILLMLSDM-DINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALS 702
Query: 1251 DPLDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTS 1310
DP + + L+ LP+ + T FL HLK VAE NKM NLA VFGPTL+R S
Sbjct: 703 DPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPS 762
Query: 1311 EDNMTHMVTHMPD--------QYKIVETLIQHHDWFFTE 1341
E +T D Q +++ +QH F E
Sbjct: 763 EVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAE 801
>gi|38679957 active breakpoint cluster region-related protein isoform
a [Homo sapiens]
Length = 859
Score = 115 bits (287), Expect = 5e-25
Identities = 77/219 (35%), Positives = 111/219 (50%), Gaps = 12/219 (5%)
Query: 1131 MRKTFEKKPTATGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNA 1190
+++T KK T G FGV++ ++ +P IV C + VE+RG+E GIYR+ G
Sbjct: 633 LKRTPSKKQT--GVFGVKISVVTKRERSK-VPYIVRQCVEEVEKRGIEEVGIYRISGVAT 689
Query: 1191 AISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKE 1250
I +++ + DI + D+N I+ LK +FR+LPEPL T+ Y F+E
Sbjct: 690 DIQALKAVFDANNKDILLMLSDM-DINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALS 748
Query: 1251 DPLDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTS 1310
DP + + L+ LP+ + T FL HLK VAE NKM NLA VFGPTL+R S
Sbjct: 749 DPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPS 808
Query: 1311 EDNMTHMVTHMPD--------QYKIVETLIQHHDWFFTE 1341
E +T D Q +++ +QH F E
Sbjct: 809 EVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAE 847
>gi|38679954 active breakpoint cluster region-related protein isoform
b [Homo sapiens]
Length = 822
Score = 115 bits (287), Expect = 5e-25
Identities = 77/219 (35%), Positives = 111/219 (50%), Gaps = 12/219 (5%)
Query: 1131 MRKTFEKKPTATGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNA 1190
+++T KK T G FGV++ ++ +P IV C + VE+RG+E GIYR+ G
Sbjct: 596 LKRTPSKKQT--GVFGVKISVVTKRERSK-VPYIVRQCVEEVEKRGIEEVGIYRISGVAT 652
Query: 1191 AISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKE 1250
I +++ + DI + D+N I+ LK +FR+LPEPL T+ Y F+E
Sbjct: 653 DIQALKAVFDANNKDILLMLSDM-DINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALS 711
Query: 1251 DPLDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTS 1310
DP + + L+ LP+ + T FL HLK VAE NKM NLA VFGPTL+R S
Sbjct: 712 DPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPS 771
Query: 1311 EDNMTHMVTHMPD--------QYKIVETLIQHHDWFFTE 1341
E +T D Q +++ +QH F E
Sbjct: 772 EVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAE 810
>gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo
sapiens]
Length = 1499
Score = 114 bits (284), Expect = 1e-24
Identities = 75/254 (29%), Positives = 128/254 (50%), Gaps = 18/254 (7%)
Query: 1097 PHSPKEESERKLLSKD---DTSPPKDKGTWRKGIPSIMRKTFEKKPTATGTFGVRLDDCP 1153
P+ E+ R+ + + +T PK K PSI + T+E + FGV L
Sbjct: 1206 PYETDEDPRRRNILRSLRRNTKKPKPKPR-----PSITKATWE-----SNYFGVPLTTV- 1254
Query: 1154 PAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKW 1213
+ IP+ ++ C + +E GL GIYRV GN + + S+Q + ++ ++D+ + +
Sbjct: 1255 -VTPEKPIPIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQRQFDQDH-NLDLAEKDF 1312
Query: 1214 RDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYET 1273
+N ++ +KSFF +LP+PL + D +EA++ D +L LK ++ P+ ++E
Sbjct: 1313 T-VNTVAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEVLKKFPKENHEV 1371
Query: 1274 LKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQ 1333
K++ +HL V+ N++ N M NL+I F PTL+R M + Q I+E IQ
Sbjct: 1372 FKYVISHLNKVSHNNKVNLMTSENLSICFWPTLMRPDFSTMDALTATRTYQ-TIIELFIQ 1430
Query: 1334 HHDWFFTEEGAEEP 1347
+FF EP
Sbjct: 1431 QCPFFFYNRPITEP 1444
>gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]
Length = 786
Score = 111 bits (278), Expect = 6e-24
Identities = 68/203 (33%), Positives = 109/203 (53%), Gaps = 8/203 (3%)
Query: 1164 IVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELN--KGMADIDIQDDKWRDLNVISS 1221
I+ C VE RG+ G+YRV G ++ + + L K ++D+++ ++ I+S
Sbjct: 398 IIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITS 457
Query: 1222 LLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHL 1281
LK + R LPEPL T + + DFI + P R+ + L+H LPE + E L L HL
Sbjct: 458 ALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHL 517
Query: 1282 KTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFFTE 1341
V+ +S++N M NL +VFGPTL+R E+ + ++ + Q +VE LI++H+ F
Sbjct: 518 TNVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAALM-DLKFQNIVVEILIENHEKIF-- 574
Query: 1342 EGAEEPLTTVQEESTVDSQPVPN 1364
P TT E + + + P PN
Sbjct: 575 --RTPPDTTFPEPTCLSASP-PN 594
>gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b [Homo
sapiens]
Length = 1075
Score = 111 bits (278), Expect = 6e-24
Identities = 56/179 (31%), Positives = 104/179 (58%), Gaps = 3/179 (1%)
Query: 1161 IPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVIS 1220
IPL+V+ C + + GL+ GI+RVPG+ ++ ++ +G D + D RD+N ++
Sbjct: 495 IPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERG-EDPLVDDQNERDINSVA 553
Query: 1221 SLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAH 1280
+LK +FR L PLF +++ D I + E+P +R+ +++++ LP +++L A
Sbjct: 554 GVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAF 613
Query: 1281 LKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFF 1339
L +++ S++N M+P NLAI FGPTL+ + V+ ++++T+I HH+ F
Sbjct: 614 LNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQ--DPVSCQAHINEVIKTIIIHHEAIF 670
>gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a [Homo
sapiens]
Length = 1099
Score = 111 bits (278), Expect = 6e-24
Identities = 56/179 (31%), Positives = 104/179 (58%), Gaps = 3/179 (1%)
Query: 1161 IPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVIS 1220
IPL+V+ C + + GL+ GI+RVPG+ ++ ++ +G D + D RD+N ++
Sbjct: 519 IPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERG-EDPLVDDQNERDINSVA 577
Query: 1221 SLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAH 1280
+LK +FR L PLF +++ D I + E+P +R+ +++++ LP +++L A
Sbjct: 578 GVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAF 637
Query: 1281 LKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFF 1339
L +++ S++N M+P NLAI FGPTL+ + V+ ++++T+I HH+ F
Sbjct: 638 LNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQ--DPVSCQAHINEVIKTIIIHHEAIF 694
>gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo
sapiens]
Length = 874
Score = 111 bits (277), Expect = 8e-24
Identities = 118/456 (25%), Positives = 189/456 (41%), Gaps = 75/456 (16%)
Query: 1168 CCKLVEERGLEYTGIYRVPGNNAAISSMQEEL--NKGMADIDIQDDKWRDLNVISSLLKS 1225
C + VE RG+ G+YR+ G N+ + + K DIDI + W D I+S LK+
Sbjct: 401 CIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELW-DNKTITSGLKN 459
Query: 1226 FFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVA 1285
+ R L EPL T + DFI A + +D R++ + L+H LPE + E L L HL V+
Sbjct: 460 YLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLVKVS 519
Query: 1286 ENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFF-TEEGA 1344
+S++N M NL ++FGPTL+R E+ + M+ ++ Q +VE LI+H++ F T
Sbjct: 520 LHSQQNLMTVSNLGVIFGPTLMRAQEETVAAMM-NIKFQNIVVEILIEHYEKIFHTAPDP 578
Query: 1345 EEPLTTVQE-----------------------------------ESTVDSQPVPNIDHLL 1369
PL Q S+ DS P+ +I+ L
Sbjct: 579 SIPLPQPQSRSGSRRTRAICLSTGSRKPRGRYTPCLAEPDSDSYSSSPDSTPMGSIESLS 638
Query: 1370 TNIG---------------RTGVSPGDVSDSATSDSTKSKGSWGSGKDQYSRELLVSSIF 1414
++ ++G P ++ ++S+ KS G W + + SRE +
Sbjct: 639 SHSSEQNSTTKSASCQPREKSGGIPW-IATPSSSNGQKSLGLWTTSPESSSRE---DATK 694
Query: 1415 AAASRKRKKPKEKAQPSSSEDELDNVFFKKENVEQCHNDTKEESKKESETLGRKQKIIIA 1474
A + P +D V KKE S + + + I A
Sbjct: 695 TDAESDCQSVASVTSPGDVSPPIDLV--KKEPYGL--------SGLKRASASSLRSISAA 744
Query: 1475 KENSTRKDPSTTKDEKISLGKESTPSEEPSPPHNSKHNKSPTLSCRFAILKESPRSLLAQ 1534
+ N K S + S+G + TP P+P K + L + + P S++A
Sbjct: 745 EGN---KSYSGSIQSLTSVGSKETPKASPNPDLPPKMCRRLRLDTASSNGYQRPGSVVAA 801
Query: 1535 KSSHLEETGSDSGTLLSTSSQASLARFSMKKSTSPE 1570
K+ E GS +S + + A +S K S E
Sbjct: 802 KAQLFENVGSPKPV---SSGRQAKAMYSCKAEHSHE 834
>gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo sapiens]
Length = 731
Score = 107 bits (266), Expect = 1e-22
Identities = 92/388 (23%), Positives = 168/388 (43%), Gaps = 61/388 (15%)
Query: 958 WKQMYVVLRGHSLYLYKDKREQTTPSE--------EEQPISVNACLIDISYSETKRKNVF 1009
W +VVL G+SL Y++ T PS E + + + + R+NV
Sbjct: 345 WGPSWVVLTGNSLVFYREP-PPTAPSSGWGPAGSRPESSVDLRGAALAHGRHLSSRRNVL 403
Query: 1010 RLTT-SDCECLFQAEDRDDMLAW-------IKTIQESSNLNEEDTGVTNRDLISRRIKEY 1061
+ T E L Q++ ++ AW I+ + + L +G +L + +E
Sbjct: 404 HIRTIPGHEFLLQSDHETELRAWHRALRTVIERLDRENPLELRLSGSGPAELSAGEDEE- 462
Query: 1062 NNLMSKAEQLPKTPRQSLSIRQTLLGAKSEPKTQSPHSPKEESERKLLSKDDTSPPKDKG 1121
+ +L P LS R++ + P+ + + + +R + + +++G
Sbjct: 463 -----EESELVSKPLLRLSSRRSSIRG---PEGTEQNRVRNKLKRLIAKRPPLQSLQERG 514
Query: 1122 TWRKGIPSIMRKTFEKKPTATGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTG 1181
R + FG +L+ + +P + +C V++RGL+ G
Sbjct: 515 LLRDQV-----------------FGCQLESLCQREGDT-VPSFLRLCIAAVDKRGLDVDG 556
Query: 1182 IYRVPGNNAAISSMQEELNKGMA-----------------DIDIQDDKWRDLNVISSLLK 1224
IYRV GN A + ++ +++ A +D+ +W D++V++ LK
Sbjct: 557 IYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDIHVVTGALK 616
Query: 1225 SFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHLKTV 1284
F R+LP+PL F A + L ++ LI +P+ +++TL++L HL V
Sbjct: 617 LFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELIGSMPKPNHDTLRYLLEHLCRV 676
Query: 1285 AENSEKNKMEPRNLAIVFGPTLVRTSED 1312
+S+KN+M P NL IVFGPTL R ++
Sbjct: 677 IAHSDKNRMTPHNLGIVFGPTLFRPEQE 704
>gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo sapiens]
Length = 547
Score = 107 bits (266), Expect = 1e-22
Identities = 92/388 (23%), Positives = 168/388 (43%), Gaps = 61/388 (15%)
Query: 958 WKQMYVVLRGHSLYLYKDKREQTTPSE--------EEQPISVNACLIDISYSETKRKNVF 1009
W +VVL G+SL Y++ T PS E + + + + R+NV
Sbjct: 161 WGPSWVVLTGNSLVFYREP-PPTAPSSGWGPAGSRPESSVDLRGAALAHGRHLSSRRNVL 219
Query: 1010 RLTT-SDCECLFQAEDRDDMLAW-------IKTIQESSNLNEEDTGVTNRDLISRRIKEY 1061
+ T E L Q++ ++ AW I+ + + L +G +L + +E
Sbjct: 220 HIRTIPGHEFLLQSDHETELRAWHRALRTVIERLDRENPLELRLSGSGPAELSAGEDEE- 278
Query: 1062 NNLMSKAEQLPKTPRQSLSIRQTLLGAKSEPKTQSPHSPKEESERKLLSKDDTSPPKDKG 1121
+ +L P LS R++ + P+ + + + +R + + +++G
Sbjct: 279 -----EESELVSKPLLRLSSRRSSIRG---PEGTEQNRVRNKLKRLIAKRPPLQSLQERG 330
Query: 1122 TWRKGIPSIMRKTFEKKPTATGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTG 1181
R + FG +L+ + +P + +C V++RGL+ G
Sbjct: 331 LLRDQV-----------------FGCQLESLCQREGDT-VPSFLRLCIAAVDKRGLDVDG 372
Query: 1182 IYRVPGNNAAISSMQEELNKGMA-----------------DIDIQDDKWRDLNVISSLLK 1224
IYRV GN A + ++ +++ A +D+ +W D++V++ LK
Sbjct: 373 IYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDIHVVTGALK 432
Query: 1225 SFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHLKTV 1284
F R+LP+PL F A + L ++ LI +P+ +++TL++L HL V
Sbjct: 433 LFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELIGSMPKPNHDTLRYLLEHLCRV 492
Query: 1285 AENSEKNKMEPRNLAIVFGPTLVRTSED 1312
+S+KN+M P NL IVFGPTL R ++
Sbjct: 493 IAHSDKNRMTPHNLGIVFGPTLFRPEQE 520
>gi|4505507 oligophrenin 1 [Homo sapiens]
Length = 802
Score = 106 bits (265), Expect = 2e-22
Identities = 64/187 (34%), Positives = 102/187 (54%), Gaps = 9/187 (4%)
Query: 1168 CCKLVEERGLEYTGIYRVPGNNAAISSMQEEL--NKGMADIDIQDDKWRDLNVISSLLKS 1225
C ++E +G++ G+YR G+N + + K D+D + W D+ I+S LK
Sbjct: 393 CINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDW-DIKTITSSLKF 451
Query: 1226 FFRKLPEPLFTNDKYADFIEANRKEDPLD-RLKTLKRLIHDLPEHHYETLKFLSAHLKTV 1284
+ R L EP+ T + + + A K D LD RL + L++ LPE + E L+ L HL V
Sbjct: 452 YLRNLSEPVMTYRLHKELVSA-AKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVNV 510
Query: 1285 AENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFF---TE 1341
E+S++N M P N+ ++FGPTL+R ED + M+ ++ Q +VE LI+H + E
Sbjct: 511 CEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMM-NIKFQNIVVEILIEHFGKIYLGPPE 569
Query: 1342 EGAEEPL 1348
E A P+
Sbjct: 570 ESAAPPV 576
>gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo sapiens]
Length = 1085
Score = 106 bits (264), Expect = 3e-22
Identities = 71/269 (26%), Positives = 132/269 (49%), Gaps = 19/269 (7%)
Query: 1079 LSIRQTLLGAKSEPKTQSPHSPKEES------ERKLLSKDDTSPPKDKGTWRKGIPSIMR 1132
+ +R+ L G+ K Q+ H + + + ++ PPK P R
Sbjct: 441 MKLREYLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTRPPNVPPK---------PQKHR 491
Query: 1133 KTFEKKPTATGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAI 1192
K+ + T F L+ + + IPLIV+ C + + GL++ GI+RV G+ +
Sbjct: 492 KSRPRSQYNTKLFNGDLETFVK-DSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEV 550
Query: 1193 SSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDP 1252
+ ++ +G + D D+N ++ +LK +FR L PLF +++ D I R ++
Sbjct: 551 NDIKNSFERGENPL-ADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNL 609
Query: 1253 LDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSED 1312
+R +++L+ LP +++L A L +++ S++N M+P NLAI FGPTL+ E
Sbjct: 610 YERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPE- 668
Query: 1313 NMTHMVTHMPDQYKIVETLIQHHDWFFTE 1341
+ V+ +I++T+I HH+ F +
Sbjct: 669 -IQDQVSCQAHVNEIIKTIIIHHETIFPD 696
>gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo
sapiens]
Length = 653
Score = 105 bits (262), Expect = 4e-22
Identities = 86/321 (26%), Positives = 145/321 (45%), Gaps = 34/321 (10%)
Query: 1115 SPPKDKGTWRKGIPSIMRKTFEKKPTATGTFGVRLDDC---PPAHTNRYIPLIVDICCKL 1171
S D W K I ++ F G FG +L+D + NR P++V+ C
Sbjct: 13 STQNDMEDWVKSIRRVIWGPF-----GGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDF 67
Query: 1172 VEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLP 1231
+ +RGL+ G++R+PG + +Q+ + G D D++ ++SLLK + R+LP
Sbjct: 68 IRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKP---SFDSNTDVHTVASLLKLYLRELP 124
Query: 1232 EPLFTNDKYADFIEANR---KEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVAENS 1288
EP+ KY DF+ + KE+ +K L + + LP +Y LK++ L V S
Sbjct: 125 EPVIPYAKYEDFLSCAKLLSKEEEAG-VKELAKQVKSLPVVNYNLLKYICRFLDEVQSYS 183
Query: 1289 EKNKMEPRNLAIVFGPTLVRTS-EDNMTHMVTHMPDQYKIVETLIQHHDWFFTEEGAEEP 1347
NKM +NLA VFGP ++R ED +T M + Q +++ +I HD F
Sbjct: 184 GVNKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQ-QLMSVMISKHDCLF-------- 234
Query: 1348 LTTVQEESTVDSQPVPNIDHLLTNIGRTGVSPGDV---SDSATSDSTKSKGSWGSGKDQY 1404
+++ + S+P + + N + + G + ++ T DS + SW +
Sbjct: 235 ----PKDAELQSKPQDGVSN--NNEIQKKATMGQLQNKENNNTKDSPSRQCSWDKSESPQ 288
Query: 1405 SRELLVSSIFAAASRKRKKPK 1425
+ S A + K PK
Sbjct: 289 RSSMNNGSPTALSGSKTNSPK 309
>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
sapiens]
Length = 748
Score = 105 bits (262), Expect = 4e-22
Identities = 86/321 (26%), Positives = 145/321 (45%), Gaps = 34/321 (10%)
Query: 1115 SPPKDKGTWRKGIPSIMRKTFEKKPTATGTFGVRLDDC---PPAHTNRYIPLIVDICCKL 1171
S D W K I ++ F G FG +L+D + NR P++V+ C
Sbjct: 108 STQNDMEDWVKSIRRVIWGPF-----GGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDF 162
Query: 1172 VEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLP 1231
+ +RGL+ G++R+PG + +Q+ + G D D++ ++SLLK + R+LP
Sbjct: 163 IRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKP---SFDSNTDVHTVASLLKLYLRELP 219
Query: 1232 EPLFTNDKYADFIEANR---KEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVAENS 1288
EP+ KY DF+ + KE+ +K L + + LP +Y LK++ L V S
Sbjct: 220 EPVIPYAKYEDFLSCAKLLSKEEEAG-VKELAKQVKSLPVVNYNLLKYICRFLDEVQSYS 278
Query: 1289 EKNKMEPRNLAIVFGPTLVRTS-EDNMTHMVTHMPDQYKIVETLIQHHDWFFTEEGAEEP 1347
NKM +NLA VFGP ++R ED +T M + Q +++ +I HD F
Sbjct: 279 GVNKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQ-QLMSVMISKHDCLF-------- 329
Query: 1348 LTTVQEESTVDSQPVPNIDHLLTNIGRTGVSPGDV---SDSATSDSTKSKGSWGSGKDQY 1404
+++ + S+P + + N + + G + ++ T DS + SW +
Sbjct: 330 ----PKDAELQSKPQDGVSN--NNEIQKKATMGQLQNKENNNTKDSPSRQCSWDKSESPQ 383
Query: 1405 SRELLVSSIFAAASRKRKKPK 1425
+ S A + K PK
Sbjct: 384 RSSMNNGSPTALSGSKTNSPK 404
Score = 37.0 bits (84), Expect = 0.19
Identities = 31/118 (26%), Positives = 50/118 (42%), Gaps = 27/118 (22%)
Query: 931 DAAKEGWLHFRPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYLYKDKREQTTPSEEEQP-- 988
+A K GWL ++ GG ++ W + VL+G LY +KD+ E P
Sbjct: 19 NAIKCGWL----------RKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGN 68
Query: 989 -ISVNACLIDISYSETKRKNVF---------RLTTSDCECLFQAEDRDDMLAWIKTIQ 1036
+S + C E K +F R+T + L A ++DM W+K+I+
Sbjct: 69 KVSEHPC-----NEENPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSIR 121
>gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens]
Length = 818
Score = 105 bits (261), Expect = 6e-22
Identities = 65/218 (29%), Positives = 116/218 (53%), Gaps = 11/218 (5%)
Query: 1157 TNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDL 1216
+ R I ++ C ++ E G++ G++RV + + + ++ L+ + D+ + D
Sbjct: 264 SGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDCCVVDVQ---EYSADP 320
Query: 1217 NVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKF 1276
+ I+ LKS+ R+LPEPL T + Y ++I+A+ ++ +L+ L LP+ ++ +++
Sbjct: 321 HAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRY 380
Query: 1277 LSAHLKTVAENSEKNKMEPRNLAIVFGPTLV-RTSEDNMTHMVTHMPDQ-YKIVETLIQH 1334
L L ++E + NKM P N+AIV GP L+ +E N+T M+T + Q I+E +IQH
Sbjct: 381 LIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGIIEPIIQH 440
Query: 1335 HDWFFTEE------GAEEPLTTVQEESTVDSQPVPNID 1366
DWFF E G V + S P P++D
Sbjct: 441 ADWFFPGEIEFNITGNYGSPVHVNHNANYSSMPSPDMD 478
>gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo
sapiens]
Length = 655
Score = 103 bits (258), Expect = 1e-21
Identities = 80/293 (27%), Positives = 137/293 (46%), Gaps = 29/293 (9%)
Query: 1143 GTFGVRLDDC---PPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEEL 1199
G FG +L+D + NR P++V+ C + +RGL+ G++R+PG + +Q+
Sbjct: 38 GIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAF 97
Query: 1200 NKGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANR---KEDPLDRL 1256
+ G D D++ ++SLLK + R+LPEP+ KY DF+ + KE+ +
Sbjct: 98 DCGEKP---SFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAG-V 153
Query: 1257 KTLKRLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTS-EDNMT 1315
K L + + LP +Y LK++ L V S NKM +NLA VFGP ++R ED +T
Sbjct: 154 KELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPLT 213
Query: 1316 HMVTHMPDQYKIVETLIQHHDWFFTEEGAEEPLTTVQEESTVDSQPVPNIDHLLTNIGRT 1375
M + Q +++ +I HD F +++ + S+P + + N +
Sbjct: 214 IMEGTVVVQ-QLMSVMISKHDCLF------------PKDAELQSKPQDGVSN--NNEIQK 258
Query: 1376 GVSPGDV---SDSATSDSTKSKGSWGSGKDQYSRELLVSSIFAAASRKRKKPK 1425
+ G + ++ T DS + SW + + S A + K PK
Sbjct: 259 KATMGQLQNKENNNTKDSPSRQCSWDKSESPQRSSMNNGSPTALSGSKTNSPK 311
>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
Length = 698
Score = 103 bits (258), Expect = 1e-21
Identities = 77/242 (31%), Positives = 120/242 (49%), Gaps = 22/242 (9%)
Query: 1139 PTATGTFGVRLDDCPPAHTNRY----IPLIVDICCKLVEERGLEYTGIYRVPGNNAAISS 1194
P G FG RL++ H +Y PL+V+ C + ERGL G++R+PG +
Sbjct: 147 PLGGGIFGQRLEETVH-HERKYGPRLAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVRD 205
Query: 1195 MQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANR--KEDP 1252
+Q+ + G + D D++ ++SLLK + R+LPEP+ +Y DF+ + +D
Sbjct: 206 LQDSFDCGEKPLF---DSTTDVHTVASLLKLYLRELPEPVVPFARYEDFLSCAQLLTKDE 262
Query: 1253 LDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTS-E 1311
+ L + + +LP+ +Y L+++ L V S NKM +NLA VFGP ++R E
Sbjct: 263 GEGTLELAKQVSNLPQANYNLLRYICKFLDEVQAYSNVNKMSVQNLATVFGPNILRPQVE 322
Query: 1312 DNMTHMVTHMPDQYKIVETLIQHHDWFFT---EEGAEEPLTTVQ-------EESTVDSQP 1361
D +T M Q+ ++ LI+ H FT EG P +Q EE T DSQ
Sbjct: 323 DPVTIMEGTSLVQH-LMTVLIRKHSQLFTAPVPEGPTSPRGGLQCAVGWGSEEVTRDSQG 381
Query: 1362 VP 1363
P
Sbjct: 382 EP 383
Score = 32.7 bits (73), Expect = 3.6
Identities = 17/45 (37%), Positives = 23/45 (51%), Gaps = 10/45 (22%)
Query: 934 KEGWLHFRPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYLYKDKRE 978
K GWL K+ ++ W+Q + VLRG L+ YKDK E
Sbjct: 40 KAGWL----------KKQRSIMKNWQQRWFVLRGDQLFYYKDKDE 74
>gi|208022687 GTPase regulator associated with the focal adhesion
kinase pp125 isoform b [Homo sapiens]
Length = 759
Score = 103 bits (256), Expect = 2e-21
Identities = 65/205 (31%), Positives = 106/205 (51%), Gaps = 10/205 (4%)
Query: 1164 IVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDD---KWRDLNVIS 1220
I+ C VE RG+ G+YR+ G N+ + + L + + D +W ++ I+
Sbjct: 392 IIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDICAEW-EIKTIT 450
Query: 1221 SLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAH 1280
S LK++ R LP PL FI+A + E+ R+ + L+H LPE + + L+ L H
Sbjct: 451 SALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNH 510
Query: 1281 LKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFFT 1340
L VA N ++N M NL +VFGPTL+R E+ + + + Q ++E LI++H+ F
Sbjct: 511 LANVANNHKQNLMTVANLGVVFGPTLLRPQEETVA-AIMDIKFQNIVIEILIENHEKIFN 569
Query: 1341 EEGAEEPLTTVQ----EESTVDSQP 1361
+ PLT Q + + DS+P
Sbjct: 570 TV-PDMPLTNAQLHLSRKKSSDSKP 593
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.126 0.355
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 78,883,104
Number of Sequences: 37866
Number of extensions: 3838568
Number of successful extensions: 16529
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 210
Number of HSP's successfully gapped in prelim test: 466
Number of HSP's that attempted gapping in prelim test: 13788
Number of HSP's gapped (non-prelim): 2798
length of query: 1958
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1841
effective length of database: 13,817,196
effective search space: 25437457836
effective search space used: 25437457836
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.