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Search of human proteins with 20128774
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
(364 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens] 733 0.0
gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ... 562 e-160
gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo s... 550 e-156
gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens] 479 e-135
gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo ... 456 e-128
gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens] 445 e-125
gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo ... 427 e-120
gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta... 334 8e-92
gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta... 334 8e-92
gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alph... 332 4e-91
gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha... 332 4e-91
gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo s... 328 5e-90
gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo ... 328 5e-90
gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo ... 328 5e-90
gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta... 326 2e-89
gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta... 326 2e-89
gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alph... 321 6e-88
gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alph... 321 6e-88
gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s... 317 8e-87
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s... 316 2e-86
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ... 316 2e-86
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ... 316 2e-86
gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens] 315 5e-86
gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens] 315 5e-86
gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s... 299 3e-81
gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo ... 276 2e-74
gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo s... 246 2e-65
gi|149408126 nemo like kinase [Homo sapiens] 246 3e-65
gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gam... 239 2e-63
gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens] 237 1e-62
>gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
Length = 364
Score = 733 bits (1893), Expect = 0.0
Identities = 364/364 (100%), Positives = 364/364 (100%)
Query: 1 MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ 60
MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ
Sbjct: 1 MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ 60
Query: 61 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ 120
SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ
Sbjct: 61 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ 120
Query: 121 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT 180
ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT
Sbjct: 121 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT 180
Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG 240
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG
Sbjct: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG 240
Query: 241 TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA 300
TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA
Sbjct: 241 TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA 300
Query: 301 EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSL 360
EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSL
Sbjct: 301 EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSL 360
Query: 361 EIEQ 364
EIEQ
Sbjct: 361 EIEQ 364
>gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo
sapiens]
Length = 360
Score = 562 bits (1449), Expect = e-160
Identities = 265/351 (75%), Positives = 312/351 (88%)
Query: 1 MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ 60
MS R FYRQELNKT+WEVP+R Q L PVGSGAYGSVC+A+D + +VAVKKLSRPFQ
Sbjct: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60
Query: 61 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ 120
S+IHA+RTYRELRLLKH+KHENVIGLLDVFTPA S+E+F++VYLVT LMGADLNNIVKCQ
Sbjct: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120
Query: 121 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT 180
L+D+HVQFL+YQ+LRGLKYIHSA IIHRDLKPSN+AVNEDCEL+ILDFGLAR D+EMT
Sbjct: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180
Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG 240
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL G+ LFPG+D+IDQLK I+ +VG
Sbjct: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240
Query: 241 TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA 300
TP E+L KISSE AR YIQSL MP+ + +++F GANPLA+DLL +MLVLDSD+R++AA
Sbjct: 241 TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA 300
Query: 301 EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPP 351
+ALAHAYF+QYHDP+DEP A+PYD+S E+++ ++EWK LTY EV+SF PP
Sbjct: 301 QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPP 351
>gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo
sapiens]
Length = 360
Score = 550 bits (1416), Expect = e-156
Identities = 257/351 (73%), Positives = 309/351 (88%)
Query: 1 MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ 60
MS R FYRQELNKT+WEVP+R Q L PVGSGAYGSVC+A+D + +VAVKKLSRPFQ
Sbjct: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60
Query: 61 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ 120
S+IHA+RTYRELRLLKH+KHENVIGLLDVFTPA S+E+F++VYLVT LMGADLNNIVKCQ
Sbjct: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120
Query: 121 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT 180
L+D+HVQFL+YQ+LRGLKYIHSA IIHRDLKPSN+AVNEDCEL+ILDFGLAR D+EMT
Sbjct: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180
Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG 240
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL G+ LFPG+D+I+QL++IM + G
Sbjct: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTG 240
Query: 241 TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA 300
TP ++ ++ S AR YIQSL MP+ + +++F GANPLA+DLL +MLVLDSD+R++AA
Sbjct: 241 TPPAYLINRMPSHEARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA 300
Query: 301 EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPP 351
+ALAHAYF+QYHDP+DEP A+PYD+S E+++ ++EWK LTY EV+SF PP
Sbjct: 301 QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPP 351
>gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]
Length = 367
Score = 479 bits (1234), Expect = e-135
Identities = 225/354 (63%), Positives = 284/354 (80%), Gaps = 3/354 (0%)
Query: 1 MSGP---RAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR 57
MS P R+GFYRQE+ KT WEV + L+PVGSGAYG+VCSA D R KVA+KKL R
Sbjct: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60
Query: 58 PFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV 117
PFQS + A+R YRELRLLKH++HENVIGLLDVFTP +++DF++ YLV MG DL ++
Sbjct: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM 120
Query: 118 KCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE 177
K + L ++ +QFLVYQ+L+GL+YIH+AGIIHRDLKP N+AVNEDCEL+ILDFGLARQAD
Sbjct: 121 KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS 180
Query: 178 EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIME 237
EMTGYV TRWYRAPE++LNWM Y QTVDIWSVGCIMAE++ GK LF GSD++DQLK IM+
Sbjct: 181 EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240
Query: 238 VVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV 297
V GTP E + ++ S+ A+ Y++ LP + +KD +SI A+PLA++LL +MLVLD++QRV
Sbjct: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300
Query: 298 SAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPP 351
+A EALAH YF HD EDEP+ + YD+S + +RTL+EWK +TY+EVLSFKPP
Sbjct: 301 TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPP 354
>gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo
sapiens]
Length = 297
Score = 456 bits (1174), Expect = e-128
Identities = 218/280 (77%), Positives = 249/280 (88%)
Query: 1 MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ 60
MS R FYRQELNKT+WEVP+R Q L PVGSGAYGSVC+A+D + +VAVKKLSRPFQ
Sbjct: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60
Query: 61 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ 120
S+IHA+RTYRELRLLKH+KHENVIGLLDVFTPA S+E+F++VYLVT LMGADLNNIVKCQ
Sbjct: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120
Query: 121 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT 180
L+D+HVQFL+YQ+LRGLKYIHSA IIHRDLKPSN+AVNEDCEL+ILDFGLAR D+EMT
Sbjct: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180
Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG 240
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL G+ LFPG+D+IDQLK I+ +VG
Sbjct: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240
Query: 241 TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPL 280
TP E+L KISSE AR YIQSL MP+ + +++F GANPL
Sbjct: 241 TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPL 280
>gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]
Length = 365
Score = 445 bits (1144), Expect = e-125
Identities = 210/347 (60%), Positives = 275/347 (79%), Gaps = 2/347 (0%)
Query: 5 RAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH 64
+ GFY+Q++NKT WE+P+ VGSGAYGSVCSA D R +KVA+KKLSRPFQS I
Sbjct: 6 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 65
Query: 65 ARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSD 124
A+R YREL LLKH++HENVIGLLDVFTPA+S+ +F + YLV M DL I+ + S+
Sbjct: 66 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSE 124
Query: 125 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVA 184
E +Q+LVYQ+L+GLKYIHSAG++HRDLKP N+AVNEDCEL+ILDFGLAR AD EMTGYV
Sbjct: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVV 184
Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSP 244
TRWYRAPE++L+WMHYNQTVDIWSVGCIMAE+L GK LF G DY+DQL +I++V G P
Sbjct: 185 TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGT 244
Query: 245 EVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 304
E + K++ + A++YIQSLP P+KD + +F A+P A DLL +ML LD D+R++AA+AL
Sbjct: 245 EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304
Query: 305 HAYFSQYHDPEDEPEA-EPYDESVEAKERTLEEWKELTYQEVLSFKP 350
H +F + DPE+E EA +P+D+S+E ++ T++EWK+ Y+E+++F P
Sbjct: 305 HPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351
>gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo
sapiens]
Length = 307
Score = 427 bits (1098), Expect = e-120
Identities = 204/257 (79%), Positives = 230/257 (89%)
Query: 1 MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ 60
MS R FYRQELNKT+WEVP+R Q L PVGSGAYGSVC+A+D + +VAVKKLSRPFQ
Sbjct: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60
Query: 61 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ 120
S+IHA+RTYRELRLLKH+KHENVIGLLDVFTPA S+E+F++VYLVT LMGADLNNIVKCQ
Sbjct: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120
Query: 121 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT 180
L+D+HVQFL+YQ+LRGLKYIHSA IIHRDLKPSN+AVNEDCEL+ILDFGLAR D+EMT
Sbjct: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180
Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG 240
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL G+ LFPG+D+IDQLK I+ +VG
Sbjct: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240
Query: 241 TPSPEVLAKISSEHART 257
TP E+L KISSE T
Sbjct: 241 TPGAELLKKISSESLST 257
>gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta2
[Homo sapiens]
Length = 427
Score = 334 bits (856), Expect = 8e-92
Identities = 175/359 (48%), Positives = 244/359 (67%), Gaps = 21/359 (5%)
Query: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67
FY E+ + + V +R Q L+P+GSGA G VC+AYDA L + VA+KKLSRPFQ+ HA+R
Sbjct: 10 FYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKR 69
Query: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127
YREL L+K + H+N+IGLL+VFTP S+E+F +VY+V LM A+L +++ + L E +
Sbjct: 70 AYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERM 128
Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVAT 185
+L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A MT YV T
Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 188
Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245
R+YRAPE++L M Y + VDIWSVGCIM E+++G LFPG+D+IDQ +++E +GTP PE
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPE 247
Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGA--------NPL----AIDLLGRMLVLDS 293
+ K+ RTY+++ P +F N L A DLL +MLV+D+
Sbjct: 248 FMKKLQPT-VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDA 306
Query: 294 DQRVSAAEALAHAYFSQYHDPEDEPEAEP---YDESVEAKERTLEEWKELTYQEVLSFK 349
+R+S EAL H Y + ++DP E EA P D+ ++ +E T+EEWKEL Y+EV+ +
Sbjct: 307 SKRISVDEALQHPYINVWYDP-SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLE 364
>gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta1
[Homo sapiens]
Length = 384
Score = 334 bits (856), Expect = 8e-92
Identities = 175/359 (48%), Positives = 244/359 (67%), Gaps = 21/359 (5%)
Query: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67
FY E+ + + V +R Q L+P+GSGA G VC+AYDA L + VA+KKLSRPFQ+ HA+R
Sbjct: 10 FYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKR 69
Query: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127
YREL L+K + H+N+IGLL+VFTP S+E+F +VY+V LM A+L +++ + L E +
Sbjct: 70 AYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERM 128
Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVAT 185
+L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A MT YV T
Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 188
Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245
R+YRAPE++L M Y + VDIWSVGCIM E+++G LFPG+D+IDQ +++E +GTP PE
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPE 247
Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGA--------NPL----AIDLLGRMLVLDS 293
+ K+ RTY+++ P +F N L A DLL +MLV+D+
Sbjct: 248 FMKKLQPT-VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDA 306
Query: 294 DQRVSAAEALAHAYFSQYHDPEDEPEAEP---YDESVEAKERTLEEWKELTYQEVLSFK 349
+R+S EAL H Y + ++DP E EA P D+ ++ +E T+EEWKEL Y+EV+ +
Sbjct: 307 SKRISVDEALQHPYINVWYDP-SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLE 364
>gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alpha2
[Homo sapiens]
Length = 427
Score = 332 bits (850), Expect = 4e-91
Identities = 175/359 (48%), Positives = 242/359 (67%), Gaps = 21/359 (5%)
Query: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67
FY E+ + + V +R Q L+P+GSGA G VC+AYDA L + VA+KKLSRPFQ+ HA+R
Sbjct: 10 FYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKR 69
Query: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127
YREL L+K + H+N+IGLL+VFTP S+E+F +VY+V LM A+L +++ + L E +
Sbjct: 70 AYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERM 128
Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVAT 185
+L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A MT YV T
Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 188
Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245
R+YRAPE++L M Y + VD+WSVGCIM E++ K LFPG DYIDQ +++E +GTP PE
Sbjct: 189 RYYRAPEVILG-MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPE 247
Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGA--------NPL----AIDLLGRMLVLDS 293
+ K+ RTY+++ P +F N L A DLL +MLV+D+
Sbjct: 248 FMKKLQPT-VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDA 306
Query: 294 DQRVSAAEALAHAYFSQYHDPEDEPEAEP---YDESVEAKERTLEEWKELTYQEVLSFK 349
+R+S EAL H Y + ++DP E EA P D+ ++ +E T+EEWKEL Y+EV+ +
Sbjct: 307 SKRISVDEALQHPYINVWYDP-SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLE 364
>gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha1
[Homo sapiens]
Length = 384
Score = 332 bits (850), Expect = 4e-91
Identities = 175/359 (48%), Positives = 242/359 (67%), Gaps = 21/359 (5%)
Query: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67
FY E+ + + V +R Q L+P+GSGA G VC+AYDA L + VA+KKLSRPFQ+ HA+R
Sbjct: 10 FYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKR 69
Query: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127
YREL L+K + H+N+IGLL+VFTP S+E+F +VY+V LM A+L +++ + L E +
Sbjct: 70 AYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERM 128
Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVAT 185
+L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A MT YV T
Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 188
Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245
R+YRAPE++L M Y + VD+WSVGCIM E++ K LFPG DYIDQ +++E +GTP PE
Sbjct: 189 RYYRAPEVILG-MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPE 247
Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGA--------NPL----AIDLLGRMLVLDS 293
+ K+ RTY+++ P +F N L A DLL +MLV+D+
Sbjct: 248 FMKKLQPT-VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDA 306
Query: 294 DQRVSAAEALAHAYFSQYHDPEDEPEAEP---YDESVEAKERTLEEWKELTYQEVLSFK 349
+R+S EAL H Y + ++DP E EA P D+ ++ +E T+EEWKEL Y+EV+ +
Sbjct: 307 SKRISVDEALQHPYINVWYDP-SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLE 364
>gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo
sapiens]
Length = 422
Score = 328 bits (841), Expect = 5e-90
Identities = 171/356 (48%), Positives = 241/356 (67%), Gaps = 19/356 (5%)
Query: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67
FY E+ + + V +R Q L+P+GSGA G VC+AYDA L + VA+KKLSRPFQ+ HA+R
Sbjct: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107
Query: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127
YREL L+K + H+N+I LL+VFTP ++E+F +VYLV LM A+L +++ + L E +
Sbjct: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERM 166
Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVAT 185
+L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A MT YV T
Sbjct: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226
Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245
R+YRAPE++L M Y + VDIWSVGCIM E+++ K LFPG DYIDQ +++E +GTP PE
Sbjct: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285
Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGA--------NPL----AIDLLGRMLVLDS 293
+ K+ R Y+++ P +F + N L A DLL +MLV+D
Sbjct: 286 FMKKLQPT-VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344
Query: 294 DQRVSAAEALAHAYFSQYHDPE--DEPEAEPYDESVEAKERTLEEWKELTYQEVLS 347
+R+S +AL H Y + ++DP + P + YD+ ++ +E T+EEWKEL Y+EV++
Sbjct: 345 AKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400
>gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo
sapiens]
Length = 464
Score = 328 bits (841), Expect = 5e-90
Identities = 171/356 (48%), Positives = 241/356 (67%), Gaps = 19/356 (5%)
Query: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67
FY E+ + + V +R Q L+P+GSGA G VC+AYDA L + VA+KKLSRPFQ+ HA+R
Sbjct: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107
Query: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127
YREL L+K + H+N+I LL+VFTP ++E+F +VYLV LM A+L +++ + L E +
Sbjct: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERM 166
Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVAT 185
+L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A MT YV T
Sbjct: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226
Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245
R+YRAPE++L M Y + VDIWSVGCIM E+++ K LFPG DYIDQ +++E +GTP PE
Sbjct: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285
Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGA--------NPL----AIDLLGRMLVLDS 293
+ K+ R Y+++ P +F + N L A DLL +MLV+D
Sbjct: 286 FMKKLQPT-VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344
Query: 294 DQRVSAAEALAHAYFSQYHDPE--DEPEAEPYDESVEAKERTLEEWKELTYQEVLS 347
+R+S +AL H Y + ++DP + P + YD+ ++ +E T+EEWKEL Y+EV++
Sbjct: 345 AKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400
>gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo
sapiens]
Length = 426
Score = 328 bits (841), Expect = 5e-90
Identities = 171/356 (48%), Positives = 241/356 (67%), Gaps = 19/356 (5%)
Query: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67
FY E+ + + V +R Q L+P+GSGA G VC+AYDA L + VA+KKLSRPFQ+ HA+R
Sbjct: 10 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 69
Query: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127
YREL L+K + H+N+I LL+VFTP ++E+F +VYLV LM A+L +++ + L E +
Sbjct: 70 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERM 128
Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVAT 185
+L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A MT YV T
Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 188
Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245
R+YRAPE++L M Y + VDIWSVGCIM E+++ K LFPG DYIDQ +++E +GTP PE
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 247
Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGA--------NPL----AIDLLGRMLVLDS 293
+ K+ R Y+++ P +F + N L A DLL +MLV+D
Sbjct: 248 FMKKLQPT-VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 306
Query: 294 DQRVSAAEALAHAYFSQYHDPE--DEPEAEPYDESVEAKERTLEEWKELTYQEVLS 347
+R+S +AL H Y + ++DP + P + YD+ ++ +E T+EEWKEL Y+EV++
Sbjct: 307 AKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 362
>gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta2
[Homo sapiens]
Length = 424
Score = 326 bits (835), Expect = 2e-89
Identities = 175/359 (48%), Positives = 239/359 (66%), Gaps = 21/359 (5%)
Query: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67
FY ++ + + V +R Q L+P+GSGA G VC+A+D L VAVKKLSRPFQ+ HA+R
Sbjct: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
Query: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127
YREL LLK + H+N+I LL+VFTP ++E+F +VYLV LM A+L ++ + L E +
Sbjct: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERM 128
Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA--DEEMTGYVAT 185
+L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A + MT YV T
Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188
Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245
R+YRAPE++L M Y + VDIWSVGCIMAE++ K LFPG DYIDQ +++E +GTPS E
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAE 247
Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIF------------RGANPLAIDLLGRMLVLDS 293
+ K+ R Y+++ P P +F + A DLL +MLV+D
Sbjct: 248 FMKKLQPT-VRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 306
Query: 294 DQRVSAAEALAHAYFSQYHDPEDEPEAEP---YDESVEAKERTLEEWKELTYQEVLSFK 349
D+R+S EAL H Y + ++DP E EA P YD +E +E +EEWKEL Y+EV+ ++
Sbjct: 307 DKRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWE 364
>gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta1
[Homo sapiens]
Length = 382
Score = 326 bits (835), Expect = 2e-89
Identities = 175/359 (48%), Positives = 239/359 (66%), Gaps = 21/359 (5%)
Query: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67
FY ++ + + V +R Q L+P+GSGA G VC+A+D L VAVKKLSRPFQ+ HA+R
Sbjct: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
Query: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127
YREL LLK + H+N+I LL+VFTP ++E+F +VYLV LM A+L ++ + L E +
Sbjct: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERM 128
Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA--DEEMTGYVAT 185
+L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A + MT YV T
Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188
Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245
R+YRAPE++L M Y + VDIWSVGCIMAE++ K LFPG DYIDQ +++E +GTPS E
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAE 247
Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIF------------RGANPLAIDLLGRMLVLDS 293
+ K+ R Y+++ P P +F + A DLL +MLV+D
Sbjct: 248 FMKKLQPT-VRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 306
Query: 294 DQRVSAAEALAHAYFSQYHDPEDEPEAEP---YDESVEAKERTLEEWKELTYQEVLSFK 349
D+R+S EAL H Y + ++DP E EA P YD +E +E +EEWKEL Y+EV+ ++
Sbjct: 307 DKRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWE 364
>gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alpha1
[Homo sapiens]
Length = 382
Score = 321 bits (823), Expect = 6e-88
Identities = 172/359 (47%), Positives = 239/359 (66%), Gaps = 21/359 (5%)
Query: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67
FY ++ + + V +R Q L+P+GSGA G VC+A+D L VAVKKLSRPFQ+ HA+R
Sbjct: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
Query: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127
YREL LLK + H+N+I LL+VFTP ++E+F +VYLV LM A+L ++ + L E +
Sbjct: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERM 128
Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA--DEEMTGYVAT 185
+L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A + MT YV T
Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188
Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245
R+YRAPE++L M Y + VDIWSVGCIM EL++G +F G+D+IDQ +++E +GTPS E
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAE 247
Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIF------------RGANPLAIDLLGRMLVLDS 293
+ K+ R Y+++ P P +F + A DLL +MLV+D
Sbjct: 248 FMKKLQPT-VRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 306
Query: 294 DQRVSAAEALAHAYFSQYHDPEDEPEAEP---YDESVEAKERTLEEWKELTYQEVLSFK 349
D+R+S EAL H Y + ++DP E EA P YD +E +E +EEWKEL Y+EV+ ++
Sbjct: 307 DKRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWE 364
>gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alpha2
[Homo sapiens]
Length = 424
Score = 321 bits (823), Expect = 6e-88
Identities = 172/359 (47%), Positives = 239/359 (66%), Gaps = 21/359 (5%)
Query: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67
FY ++ + + V +R Q L+P+GSGA G VC+A+D L VAVKKLSRPFQ+ HA+R
Sbjct: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
Query: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127
YREL LLK + H+N+I LL+VFTP ++E+F +VYLV LM A+L ++ + L E +
Sbjct: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERM 128
Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA--DEEMTGYVAT 185
+L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A + MT YV T
Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188
Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 245
R+YRAPE++L M Y + VDIWSVGCIM EL++G +F G+D+IDQ +++E +GTPS E
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAE 247
Query: 246 VLAKISSEHARTYIQSLPPMPQKDLSSIF------------RGANPLAIDLLGRMLVLDS 293
+ K+ R Y+++ P P +F + A DLL +MLV+D
Sbjct: 248 FMKKLQPT-VRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 306
Query: 294 DQRVSAAEALAHAYFSQYHDPEDEPEAEP---YDESVEAKERTLEEWKELTYQEVLSFK 349
D+R+S EAL H Y + ++DP E EA P YD +E +E +EEWKEL Y+EV+ ++
Sbjct: 307 DKRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWE 364
>gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo
sapiens]
Length = 379
Score = 317 bits (813), Expect = 8e-87
Identities = 162/340 (47%), Positives = 231/340 (67%), Gaps = 9/340 (2%)
Query: 18 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77
++V R L+ +G GAYG V SAYD + +VA+KK+S PF+ + +RT RE+++L
Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94
Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRG 137
+HENVIG+ D+ A+++E +VY+V LM DL ++K Q LS++H+ + +YQ+LRG
Sbjct: 95 FRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE------MTGYVATRWYRAP 191
LKYIHSA ++HRDLKPSN+ +N C+L+I DFGLAR AD E +T YVATRWYRAP
Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251
EIMLN Y +++DIWSVGCI+AE+L + +FPG Y+DQL I+ ++G+PS E L I
Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273
Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311
+ AR Y+QSLP + + +F ++ A+DLL RML + ++R++ EALAH Y QY
Sbjct: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 333
Query: 312 HDPEDEPEA-EPYDESVEAKERTLEEWKELTYQEVLSFKP 350
+DP DEP A EP+ ++E + E KEL +QE F+P
Sbjct: 334 YDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQP 373
>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 316 bits (810), Expect = 2e-86
Identities = 161/340 (47%), Positives = 226/340 (66%), Gaps = 9/340 (2%)
Query: 18 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77
++V + + +G+GAYG V SA Q+VA+KK+ F + +A+RT REL++LKH
Sbjct: 49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 108
Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV-KCQALSDEHVQFLVYQLLR 136
KH+N+I + D+ P +F VY+V LM +DL+ I+ Q L+ EHV++ +YQLLR
Sbjct: 109 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLR 168
Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR-----QADEE--MTGYVATRWYR 189
GLKY+HSA +IHRDLKPSN+ VNE+CEL+I DFG+AR A+ + MT YVATRWYR
Sbjct: 169 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 228
Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAK 249
APE+ML+ Y Q +D+WSVGCI E+L + LFPG +Y+ QL+ IM V+GTPSP V+
Sbjct: 229 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 288
Query: 250 ISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS 309
+ +E R YIQSLPP +++ GA+ A+ LLGRML + R+SAA AL H + +
Sbjct: 289 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 348
Query: 310 QYHDPEDEPE-AEPYDESVEAKERTLEEWKELTYQEVLSF 348
+YHDP+DEP+ A P+D + + + T E KE E+ F
Sbjct: 349 KYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDF 388
>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 316 bits (810), Expect = 2e-86
Identities = 161/340 (47%), Positives = 226/340 (66%), Gaps = 9/340 (2%)
Query: 18 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77
++V + + +G+GAYG V SA Q+VA+KK+ F + +A+RT REL++LKH
Sbjct: 49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 108
Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV-KCQALSDEHVQFLVYQLLR 136
KH+N+I + D+ P +F VY+V LM +DL+ I+ Q L+ EHV++ +YQLLR
Sbjct: 109 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLR 168
Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR-----QADEE--MTGYVATRWYR 189
GLKY+HSA +IHRDLKPSN+ VNE+CEL+I DFG+AR A+ + MT YVATRWYR
Sbjct: 169 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 228
Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAK 249
APE+ML+ Y Q +D+WSVGCI E+L + LFPG +Y+ QL+ IM V+GTPSP V+
Sbjct: 229 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 288
Query: 250 ISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS 309
+ +E R YIQSLPP +++ GA+ A+ LLGRML + R+SAA AL H + +
Sbjct: 289 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 348
Query: 310 QYHDPEDEPE-AEPYDESVEAKERTLEEWKELTYQEVLSF 348
+YHDP+DEP+ A P+D + + + T E KE E+ F
Sbjct: 349 KYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDF 388
>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 316 bits (810), Expect = 2e-86
Identities = 161/340 (47%), Positives = 226/340 (66%), Gaps = 9/340 (2%)
Query: 18 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77
++V + + +G+GAYG V SA Q+VA+KK+ F + +A+RT REL++LKH
Sbjct: 49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 108
Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV-KCQALSDEHVQFLVYQLLR 136
KH+N+I + D+ P +F VY+V LM +DL+ I+ Q L+ EHV++ +YQLLR
Sbjct: 109 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLR 168
Query: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR-----QADEE--MTGYVATRWYR 189
GLKY+HSA +IHRDLKPSN+ VNE+CEL+I DFG+AR A+ + MT YVATRWYR
Sbjct: 169 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 228
Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAK 249
APE+ML+ Y Q +D+WSVGCI E+L + LFPG +Y+ QL+ IM V+GTPSP V+
Sbjct: 229 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 288
Query: 250 ISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS 309
+ +E R YIQSLPP +++ GA+ A+ LLGRML + R+SAA AL H + +
Sbjct: 289 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 348
Query: 310 QYHDPEDEPE-AEPYDESVEAKERTLEEWKELTYQEVLSF 348
+YHDP+DEP+ A P+D + + + T E KE E+ F
Sbjct: 349 KYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDF 388
>gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 315 bits (806), Expect = 5e-86
Identities = 162/352 (46%), Positives = 232/352 (65%), Gaps = 9/352 (2%)
Query: 6 AGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHA 65
AG + + V++V R L +G GAYG VCSAYD + +VA+KK+S PF+ +
Sbjct: 7 AGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYC 65
Query: 66 RRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDE 125
+RT RE+++L +HEN+IG+ D+ A +IE +VY+V LM DL ++K Q LS++
Sbjct: 66 QRTLREIKILLRFRHENIIGINDIIR-APTIEQMKDVYIVQDLMETDLYKLLKTQHLSND 124
Query: 126 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE------M 179
H+ + +YQ+LRGLKYIHSA ++HRDLKPSN+ +N C+L+I DFGLAR AD + +
Sbjct: 125 HICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFL 184
Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVV 239
T YVATRWYRAPEIMLN Y +++DIWSVGCI+AE+L + +FPG Y+DQL I+ ++
Sbjct: 185 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGIL 244
Query: 240 GTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSA 299
G+PS E L I + AR Y+ SLP + + +F A+ A+DLL +ML + +R+
Sbjct: 245 GSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEV 304
Query: 300 AEALAHAYFSQYHDPEDEPEAE-PYDESVEAKERTLEEWKELTYQEVLSFKP 350
+ALAH Y QY+DP DEP AE P+ +E + E+ KEL ++E F+P
Sbjct: 305 EQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQP 356
>gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 315 bits (806), Expect = 5e-86
Identities = 162/352 (46%), Positives = 232/352 (65%), Gaps = 9/352 (2%)
Query: 6 AGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHA 65
AG + + V++V R L +G GAYG VCSAYD + +VA+KK+S PF+ +
Sbjct: 7 AGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYC 65
Query: 66 RRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDE 125
+RT RE+++L +HEN+IG+ D+ A +IE +VY+V LM DL ++K Q LS++
Sbjct: 66 QRTLREIKILLRFRHENIIGINDIIR-APTIEQMKDVYIVQDLMETDLYKLLKTQHLSND 124
Query: 126 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE------M 179
H+ + +YQ+LRGLKYIHSA ++HRDLKPSN+ +N C+L+I DFGLAR AD + +
Sbjct: 125 HICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFL 184
Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVV 239
T YVATRWYRAPEIMLN Y +++DIWSVGCI+AE+L + +FPG Y+DQL I+ ++
Sbjct: 185 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGIL 244
Query: 240 GTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSA 299
G+PS E L I + AR Y+ SLP + + +F A+ A+DLL +ML + +R+
Sbjct: 245 GSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEV 304
Query: 300 AEALAHAYFSQYHDPEDEPEAE-PYDESVEAKERTLEEWKELTYQEVLSFKP 350
+ALAH Y QY+DP DEP AE P+ +E + E+ KEL ++E F+P
Sbjct: 305 EQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQP 356
>gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo
sapiens]
Length = 357
Score = 299 bits (765), Expect = 3e-81
Identities = 152/321 (47%), Positives = 217/321 (67%), Gaps = 8/321 (2%)
Query: 18 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77
++V R L+ +G GAYG V SAYD + +VA+KK+S PF+ + +RT RE+++L
Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94
Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRG 137
+HENVIG+ D+ A+++E +VY+V LM DL ++K Q LS++H+ + +YQ+LRG
Sbjct: 95 FRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE------MTGYVATRWYRAP 191
LKYIHSA ++HRDLKPSN+ +N C+L+I DFGLAR AD E +T YVATRWYRAP
Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251
EIMLN Y +++DIWSVGCI+AE+L + +FPG Y+DQL I+ ++G+PS E L I
Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273
Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311
+ AR Y+QSLP + + +F ++ A+DLL RML + ++R++ EALAH Y QY
Sbjct: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 333
Query: 312 HDPEDEPEAEPYDESVEAKER 332
+DP DE P + A E+
Sbjct: 334 YDPTDEVGQSPAAVGLGAGEQ 354
>gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo
sapiens]
Length = 335
Score = 276 bits (706), Expect = 2e-74
Identities = 149/340 (43%), Positives = 207/340 (60%), Gaps = 53/340 (15%)
Query: 18 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77
++V R L+ +G GAYG V SAYD + +VA+KK+S PF+ + +RT RE+++L
Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94
Query: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRG 137
+HENVIG+ D+ A+++E +VY+V LM DL ++K Q LS++H+ + +YQ+LRG
Sbjct: 95 FRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
Query: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE------MTGYVATRWYRAP 191
LKYIHSA ++HRDLKPSN+ +N C+L+I DFGLAR AD E +T YVATRWYRAP
Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251
EIMLN Y +++DIWSVGCI+AE+L + +FPG Y+DQL I
Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI---------------- 257
Query: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311
LA+DLL RML + ++R++ EALAH Y QY
Sbjct: 258 ----------------------------LALDLLDRMLTFNPNKRITVEEALAHPYLEQY 289
Query: 312 HDPEDEPEA-EPYDESVEAKERTLEEWKELTYQEVLSFKP 350
+DP DEP A EP+ ++E + E KEL +QE F+P
Sbjct: 290 YDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQP 329
>gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo
sapiens]
Length = 677
Score = 246 bits (628), Expect = 2e-65
Identities = 126/249 (50%), Positives = 171/249 (68%), Gaps = 9/249 (3%)
Query: 109 MGADLNNIV-KCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRIL 167
M +DL+ I+ Q L+ EHV++ +YQLLRGLKY+HSA +IHRDLKPSN+ VNE+CEL+I
Sbjct: 1 MESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIG 60
Query: 168 DFGLAR-----QADEE--MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGK 220
DFG+AR A+ + MT YVATRWYRAPE+ML+ Y Q +D+WSVGCI E+L +
Sbjct: 61 DFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARR 120
Query: 221 ALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPL 280
LFPG +Y+ QL+ IM V+GTPSP V+ + +E R YIQSLPP +++ GA+
Sbjct: 121 QLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQ 180
Query: 281 AIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPE-AEPYDESVEAKERTLEEWKE 339
A+ LLGRML + R+SAA AL H + ++YHDP+DEP+ A P+D + + + T E KE
Sbjct: 181 ALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKE 240
Query: 340 LTYQEVLSF 348
E+ F
Sbjct: 241 AIVAEIEDF 249
>gi|149408126 nemo like kinase [Homo sapiens]
Length = 527
Score = 246 bits (627), Expect = 3e-65
Identities = 147/349 (42%), Positives = 211/349 (60%), Gaps = 34/349 (9%)
Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLL 87
RP+G GA+G V S D R ++VA+KK+ FQ+L+ +R +REL++L KH+NV+ L
Sbjct: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201
Query: 88 DVFTPATSIEDFSEVYLVTTLMGADLNNI-VKCQALSDEHVQFLVYQLLRGLKYIHSAGI 146
D+ P I+ F E+Y+VT LM +DL+ I V Q LS +HV+ +YQ+LRGLKY+HSAGI
Sbjct: 202 DILQPP-HIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260
Query: 147 IHRDLKPSNVAVNEDCELRILDFGLAR--QADE--EMTGYVATRWYRAPEIMLNWMHYNQ 202
+HRD+KP N+ VN +C L+I DFGLAR + DE MT V T++YRAPEI++ HY+
Sbjct: 261 LHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSN 320
Query: 203 TVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYI--- 259
+DIWSVGCI AELL + LF I QL I +++GTPS E + + + E A+ +I
Sbjct: 321 AIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAM-RTACEGAKAHILRG 379
Query: 260 -QSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ----YH-- 312
P +P L ++ A A+ LL RMLV D +R+SA +ALAH Y + YH
Sbjct: 380 PHKQPSLPV--LYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTC 437
Query: 313 --------------DPEDEPEAEP-YDESVEAKERTLEEWKELTYQEVL 346
+ EP P +D++ E ++ + KE+ +Q +L
Sbjct: 438 MCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFIL 486
>gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gamma
[Homo sapiens]
Length = 242
Score = 239 bits (611), Expect = 2e-63
Identities = 123/224 (54%), Positives = 164/224 (73%), Gaps = 4/224 (1%)
Query: 8 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67
FY ++ + + V +R Q L+P+GSGA G VC+A+D L VAVKKLSRPFQ+ HA+R
Sbjct: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
Query: 68 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHV 127
YREL LLK + H+N+I LL+VFTP ++E+F +VYLV LM A+L ++ + L E +
Sbjct: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERM 128
Query: 128 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA--DEEMTGYVAT 185
+L+YQ+L G+K++HSAGIIHRDLKPSN+ V DC L+ILDFGLAR A + MT YV T
Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188
Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYI 229
R+YRAPE++L M Y + VDIWSVGCIM EL++G +F G+D I
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDRI 231
>gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]
Length = 544
Score = 237 bits (604), Expect = 1e-62
Identities = 132/332 (39%), Positives = 199/332 (59%), Gaps = 17/332 (5%)
Query: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL-KHENVIGL 86
R +G GAYG V A D R + VA+KK+ F+ A+RT+RE+ LL+ H N+I L
Sbjct: 17 RQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNIISL 76
Query: 87 LDVFTPATSIEDFSEVYLVTTLMGADLNNIV-KCQALSDEHVQFLVYQLLRGLKYIHSAG 145
LDV E+ ++YLV M DLN ++ K L D HV+ + YQLLR +++HS
Sbjct: 77 LDVIRA----ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGH 132
Query: 146 IIHRDLKPSNVAVNEDCELRILDFGLARQA--------DEEMTGYVATRWYRAPEIMLNW 197
++HRD KPSNV ++ +C +++ DFGLAR D+ +T YVATRWYRAPE++L+
Sbjct: 133 VVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSS 192
Query: 198 MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHART 257
Y VD+WS+GCI+ E+L+G+ LFPG+ + QL+ I+E + PS E L + S +
Sbjct: 193 HRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRAS 252
Query: 258 YIQSLPPMPQKDLSSIF-RGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPED 316
+ L P++ L ++ +P A+DLL R+LV D+R+SA +AL H Y ++H P D
Sbjct: 253 VLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQRFHCPSD 312
Query: 317 E--PEAEPYDESVEAKERTLEEWKELTYQEVL 346
E EA+ + E + ++ E++ YQ +L
Sbjct: 313 EWAREADVRPRAHEGVQLSVPEYRSRVYQMIL 344
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,281,562
Number of Sequences: 37866
Number of extensions: 705340
Number of successful extensions: 5278
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 739
Number of HSP's successfully gapped in prelim test: 89
Number of HSP's that attempted gapping in prelim test: 3033
Number of HSP's gapped (non-prelim): 1139
length of query: 364
length of database: 18,247,518
effective HSP length: 104
effective length of query: 260
effective length of database: 14,309,454
effective search space: 3720458040
effective search space used: 3720458040
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.