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Search of human proteins with 20127541
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20127541 serum/glucocorticoid regulated kinase 2 isoform
beta [Homo sapiens]
(427 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 894 0.0
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 757 0.0
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 546 e-155
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 546 e-155
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 546 e-155
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 546 e-155
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 513 e-145
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 513 e-145
gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [H... 434 e-122
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 342 4e-94
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 342 4e-94
gi|4502023 AKT2 kinase [Homo sapiens] 338 7e-93
gi|62241015 AKT1 kinase [Homo sapiens] 333 2e-91
gi|62241013 AKT1 kinase [Homo sapiens] 333 2e-91
gi|62241011 AKT1 kinase [Homo sapiens] 333 2e-91
gi|133908623 protein kinase C, iota [Homo sapiens] 303 2e-82
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 302 3e-82
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 299 4e-81
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] 295 4e-80
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] 295 4e-80
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 295 4e-80
gi|4885563 protein kinase C, epsilon [Homo sapiens] 293 2e-79
gi|28557781 protein kinase C, eta [Homo sapiens] 289 4e-78
gi|13384594 protein kinase C, gamma [Homo sapiens] 284 9e-77
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 283 2e-76
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 283 2e-76
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 281 8e-76
gi|4506067 protein kinase C, alpha [Homo sapiens] 279 3e-75
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 278 7e-75
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 278 9e-75
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 894 bits (2311), Expect = 0.0
Identities = 427/427 (100%), Positives = 427/427 (100%)
Query: 1 MQGLLTSGRKPSGGGRCTGRGGWRGQWCLKPWMGGADPPTPTLSCLLLPVPPELPDHCYR 60
MQGLLTSGRKPSGGGRCTGRGGWRGQWCLKPWMGGADPPTPTLSCLLLPVPPELPDHCYR
Sbjct: 1 MQGLLTSGRKPSGGGRCTGRGGWRGQWCLKPWMGGADPPTPTLSCLLLPVPPELPDHCYR 60
Query: 61 MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAF 120
MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAF
Sbjct: 61 MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAF 120
Query: 121 YAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGE 180
YAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGE
Sbjct: 121 YAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGE 180
Query: 181 LFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL 240
LFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL
Sbjct: 181 LFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL 240
Query: 241 CKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVS 300
CKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVS
Sbjct: 241 CKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVS 300
Query: 301 QMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDL 360
QMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDL
Sbjct: 301 QMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDL 360
Query: 361 YHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPE 420
YHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPE
Sbjct: 361 YHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPE 420
Query: 421 DDDILDC 427
DDDILDC
Sbjct: 421 DDDILDC 427
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 757 bits (1954), Expect = 0.0
Identities = 367/367 (100%), Positives = 367/367 (100%)
Query: 61 MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAF 120
MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAF
Sbjct: 1 MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAF 60
Query: 121 YAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGE 180
YAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGE
Sbjct: 61 YAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGE 120
Query: 181 LFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL 240
LFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL
Sbjct: 121 LFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL 180
Query: 241 CKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVS 300
CKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVS
Sbjct: 181 CKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVS 240
Query: 301 QMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDL 360
QMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDL
Sbjct: 241 QMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDL 300
Query: 361 YHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPE 420
YHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPE
Sbjct: 301 YHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPE 360
Query: 421 DDDILDC 427
DDDILDC
Sbjct: 361 DDDILDC 367
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 546 bits (1408), Expect = e-155
Identities = 266/391 (68%), Positives = 321/391 (82%), Gaps = 14/391 (3%)
Query: 38 PPTPTLSCLLLPVPPELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDF 97
P ++ + P PEL MN++P+ PSP INLGPS+NP+A+P+DF F
Sbjct: 52 PEVQSILKISQPQEPEL------MNANPSPPPSPSQQ-----INLGPSSNPHAKPSDFHF 100
Query: 98 LKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLV 157
LKVIGKG++GKVLLA+ K++ FYAVKVLQKK+ILKKKE+ HIM+ER+VLLKNV+HPFLV
Sbjct: 101 LKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLV 160
Query: 158 GLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIY 217
GL +SFQT +KLYFVLDY+NGGELF+HLQRER FLEPRARFYAAE+ASA+GYLHSLNI+Y
Sbjct: 161 GLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVY 220
Query: 218 RDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDW 277
RDLKPENILLD QGH+VLTDFGLCKE +E TTSTFCGTPEYLAPEVL K+PYDR VDW
Sbjct: 221 RDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDW 280
Query: 278 WCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRL 337
WCLGAVLYEML+GLPPFYS++ ++MY+NIL++PLQ+ T +A LL+ LL KD+ +RL
Sbjct: 281 WCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL 340
Query: 338 GSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGC 397
G+K DF+EIK+HVFFS INWDDL +K++TPPFNPNV+GP DL+HFDPEFT+E V SIG
Sbjct: 341 GAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGK 400
Query: 398 TPDTV---ASSSGASSAFLGFSYAPEDDDIL 425
+PD+V AS A+ AFLGFSYAP D L
Sbjct: 401 SPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 431
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 546 bits (1408), Expect = e-155
Identities = 266/391 (68%), Positives = 321/391 (82%), Gaps = 14/391 (3%)
Query: 38 PPTPTLSCLLLPVPPELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDF 97
P ++ + P PEL MN++P+ PSP INLGPS+NP+A+P+DF F
Sbjct: 66 PEVQSILKISQPQEPEL------MNANPSPPPSPSQQ-----INLGPSSNPHAKPSDFHF 114
Query: 98 LKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLV 157
LKVIGKG++GKVLLA+ K++ FYAVKVLQKK+ILKKKE+ HIM+ER+VLLKNV+HPFLV
Sbjct: 115 LKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLV 174
Query: 158 GLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIY 217
GL +SFQT +KLYFVLDY+NGGELF+HLQRER FLEPRARFYAAE+ASA+GYLHSLNI+Y
Sbjct: 175 GLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVY 234
Query: 218 RDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDW 277
RDLKPENILLD QGH+VLTDFGLCKE +E TTSTFCGTPEYLAPEVL K+PYDR VDW
Sbjct: 235 RDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDW 294
Query: 278 WCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRL 337
WCLGAVLYEML+GLPPFYS++ ++MY+NIL++PLQ+ T +A LL+ LL KD+ +RL
Sbjct: 295 WCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL 354
Query: 338 GSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGC 397
G+K DF+EIK+HVFFS INWDDL +K++TPPFNPNV+GP DL+HFDPEFT+E V SIG
Sbjct: 355 GAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGK 414
Query: 398 TPDTV---ASSSGASSAFLGFSYAPEDDDIL 425
+PD+V AS A+ AFLGFSYAP D L
Sbjct: 415 SPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 445
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 546 bits (1408), Expect = e-155
Identities = 266/391 (68%), Positives = 321/391 (82%), Gaps = 14/391 (3%)
Query: 38 PPTPTLSCLLLPVPPELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDF 97
P ++ + P PEL MN++P+ PSP INLGPS+NP+A+P+DF F
Sbjct: 80 PEVQSILKISQPQEPEL------MNANPSPPPSPSQQ-----INLGPSSNPHAKPSDFHF 128
Query: 98 LKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLV 157
LKVIGKG++GKVLLA+ K++ FYAVKVLQKK+ILKKKE+ HIM+ER+VLLKNV+HPFLV
Sbjct: 129 LKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLV 188
Query: 158 GLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIY 217
GL +SFQT +KLYFVLDY+NGGELF+HLQRER FLEPRARFYAAE+ASA+GYLHSLNI+Y
Sbjct: 189 GLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVY 248
Query: 218 RDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDW 277
RDLKPENILLD QGH+VLTDFGLCKE +E TTSTFCGTPEYLAPEVL K+PYDR VDW
Sbjct: 249 RDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDW 308
Query: 278 WCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRL 337
WCLGAVLYEML+GLPPFYS++ ++MY+NIL++PLQ+ T +A LL+ LL KD+ +RL
Sbjct: 309 WCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL 368
Query: 338 GSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGC 397
G+K DF+EIK+HVFFS INWDDL +K++TPPFNPNV+GP DL+HFDPEFT+E V SIG
Sbjct: 369 GAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGK 428
Query: 398 TPDTV---ASSSGASSAFLGFSYAPEDDDIL 425
+PD+V AS A+ AFLGFSYAP D L
Sbjct: 429 SPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 459
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 546 bits (1408), Expect = e-155
Identities = 266/391 (68%), Positives = 321/391 (82%), Gaps = 14/391 (3%)
Query: 38 PPTPTLSCLLLPVPPELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDF 97
P ++ + P PEL MN++P+ PSP INLGPS+NP+A+P+DF F
Sbjct: 147 PEVQSILKISQPQEPEL------MNANPSPPPSPSQQ-----INLGPSSNPHAKPSDFHF 195
Query: 98 LKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLV 157
LKVIGKG++GKVLLA+ K++ FYAVKVLQKK+ILKKKE+ HIM+ER+VLLKNV+HPFLV
Sbjct: 196 LKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLV 255
Query: 158 GLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIY 217
GL +SFQT +KLYFVLDY+NGGELF+HLQRER FLEPRARFYAAE+ASA+GYLHSLNI+Y
Sbjct: 256 GLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVY 315
Query: 218 RDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDW 277
RDLKPENILLD QGH+VLTDFGLCKE +E TTSTFCGTPEYLAPEVL K+PYDR VDW
Sbjct: 316 RDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDW 375
Query: 278 WCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRL 337
WCLGAVLYEML+GLPPFYS++ ++MY+NIL++PLQ+ T +A LL+ LL KD+ +RL
Sbjct: 376 WCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL 435
Query: 338 GSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGC 397
G+K DF+EIK+HVFFS INWDDL +K++TPPFNPNV+GP DL+HFDPEFT+E V SIG
Sbjct: 436 GAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGK 495
Query: 398 TPDTV---ASSSGASSAFLGFSYAPEDDDIL 425
+PD+V AS A+ AFLGFSYAP D L
Sbjct: 496 SPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 526
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 513 bits (1321), Expect = e-145
Identities = 244/349 (69%), Positives = 289/349 (82%), Gaps = 3/349 (0%)
Query: 79 NINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQS 138
NINLGPS NP+A+PTDFDFLKVIGKG++GKVLLAKRK DG FYAVKVLQKK +L +KEQ
Sbjct: 146 NINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQK 205
Query: 139 HIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARF 198
HIMAER+VLLKNV+HPFLVGL YSFQT EKLYFVLD+VNGGELFFHLQRER F E RARF
Sbjct: 206 HIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARF 265
Query: 199 YAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTP 258
YAAE+ASA+GYLHS+ I+YRDLKPENILLD GHVVLTDFGLCKEG+ DTT+TFCGTP
Sbjct: 266 YAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP 325
Query: 259 EYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRT 318
EYLAPEV+RK+PYD VDWWCLGAVLYEML+GLPPFY +DV++MY+NILH+PL + G +
Sbjct: 326 EYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVS 385
Query: 319 VAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPAD 378
+ A +L+ LL KD++ RLG+K DFLEI+NH FF ++W DL K++ PPFNPNV GP D
Sbjct: 386 LTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDD 445
Query: 379 LKHFDPEFTQEAVSKSIGCTPD---TVASSSGASSAFLGFSYAPEDDDI 424
+++FD FT+E V S+ + D AS A AF+GFSYAP +D+
Sbjct: 446 IRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDL 494
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 513 bits (1321), Expect = e-145
Identities = 244/349 (69%), Positives = 289/349 (82%), Gaps = 3/349 (0%)
Query: 79 NINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQS 138
NINLGPS NP+A+PTDFDFLKVIGKG++GKVLLAKRK DG FYAVKVLQKK +L +KEQ
Sbjct: 146 NINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQK 205
Query: 139 HIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARF 198
HIMAER+VLLKNV+HPFLVGL YSFQT EKLYFVLD+VNGGELFFHLQRER F E RARF
Sbjct: 206 HIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARF 265
Query: 199 YAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTP 258
YAAE+ASA+GYLHS+ I+YRDLKPENILLD GHVVLTDFGLCKEG+ DTT+TFCGTP
Sbjct: 266 YAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP 325
Query: 259 EYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRT 318
EYLAPEV+RK+PYD VDWWCLGAVLYEML+GLPPFY +DV++MY+NILH+PL + G +
Sbjct: 326 EYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVS 385
Query: 319 VAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPAD 378
+ A +L+ LL KD++ RLG+K DFLEI+NH FF ++W DL K++ PPFNPNV GP D
Sbjct: 386 LTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDD 445
Query: 379 LKHFDPEFTQEAVSKSIGCTPD---TVASSSGASSAFLGFSYAPEDDDI 424
+++FD FT+E V S+ + D AS A AF+GFSYAP +D+
Sbjct: 446 IRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDL 494
>gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [Homo
sapiens]
Length = 464
Score = 434 bits (1117), Expect = e-122
Identities = 217/349 (62%), Positives = 259/349 (74%), Gaps = 35/349 (10%)
Query: 79 NINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQS 138
NINLGPS NP+A+PTDFDFLKVIGKG++GKVLLAKRK DG FYAVKVLQKK +L +KEQ
Sbjct: 146 NINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQK 205
Query: 139 HIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARF 198
HIMAER+VLLKNV+HPFLVGL YSFQT EKLYFVLD+VNGGELFFHLQRER F E RARF
Sbjct: 206 HIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARF 265
Query: 199 YAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTP 258
YAAE+ASA+GYLHS+ I+YRDLKPENILLD GHVVLTDFGLCKEG+ DTT+TFCGTP
Sbjct: 266 YAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP 325
Query: 259 EYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRT 318
E PPFY +DV++MY+NILH+PL + G +
Sbjct: 326 E--------------------------------PPFYCRDVAEMYDNILHKPLSLRPGVS 353
Query: 319 VAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPAD 378
+ A +L+ LL KD++ RLG+K DFLEI+NH FF ++W DL K++ PPFNPNV GP D
Sbjct: 354 LTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDD 413
Query: 379 LKHFDPEFTQEAVSKSIGCTPD---TVASSSGASSAFLGFSYAPEDDDI 424
+++FD FT+E V S+ + D AS A AF+GFSYAP +D+
Sbjct: 414 IRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDL 462
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 342 bits (877), Expect = 4e-94
Identities = 170/334 (50%), Positives = 222/334 (66%), Gaps = 5/334 (1%)
Query: 60 RMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGA 119
RMN SP S + ++ + + DFD+LK++GKG +GKV+L + K+ G
Sbjct: 116 RMNCSPT---SQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGK 172
Query: 120 FYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGG 179
+YA+K+L+K+ I+ K E +H + E VL KN RHPFL L+YSFQT ++L FV++YVNGG
Sbjct: 173 YYAMKILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDRLCFVMEYVNGG 231
Query: 180 ELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFG 239
ELFFHL RER F E R RFY AE+ SA+ YLHS I+YRDLK EN++LD GH+ +TDFG
Sbjct: 232 ELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFG 291
Query: 240 LCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDV 299
LCKEG+ T TFCGTPEYLAPEVL Y RAVDWW LG V+YEM+ G PFY+QD
Sbjct: 292 LCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH 351
Query: 300 SQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRL-GSKADFLEIKNHVFFSPINWD 358
+++E IL + ++ P + A LL LL KD +RL G D EI H FFS +NW
Sbjct: 352 EKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQ 411
Query: 359 DLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVS 392
D+Y K+L PPF P VT D ++FD EFT + ++
Sbjct: 412 DVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTIT 445
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 342 bits (877), Expect = 4e-94
Identities = 170/334 (50%), Positives = 222/334 (66%), Gaps = 5/334 (1%)
Query: 60 RMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGA 119
RMN SP S + ++ + + DFD+LK++GKG +GKV+L + K+ G
Sbjct: 116 RMNCSPT---SQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGK 172
Query: 120 FYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGG 179
+YA+K+L+K+ I+ K E +H + E VL KN RHPFL L+YSFQT ++L FV++YVNGG
Sbjct: 173 YYAMKILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDRLCFVMEYVNGG 231
Query: 180 ELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFG 239
ELFFHL RER F E R RFY AE+ SA+ YLHS I+YRDLK EN++LD GH+ +TDFG
Sbjct: 232 ELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFG 291
Query: 240 LCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDV 299
LCKEG+ T TFCGTPEYLAPEVL Y RAVDWW LG V+YEM+ G PFY+QD
Sbjct: 292 LCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH 351
Query: 300 SQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRL-GSKADFLEIKNHVFFSPINWD 358
+++E IL + ++ P + A LL LL KD +RL G D EI H FFS +NW
Sbjct: 352 EKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQ 411
Query: 359 DLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVS 392
D+Y K+L PPF P VT D ++FD EFT + ++
Sbjct: 412 DVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTIT 445
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 338 bits (866), Expect = 7e-93
Identities = 164/325 (50%), Positives = 220/325 (67%), Gaps = 3/325 (0%)
Query: 70 SPQPSRANGNINLGPS-ANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQK 128
SP S + + S A DFD+LK++GKG +GKV+L + K+ G +YA+K+L+K
Sbjct: 126 SPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRK 185
Query: 129 KSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRE 188
+ I+ K E +H + E VL +N RHPFL L+Y+FQT ++L FV++Y NGGELFFHL RE
Sbjct: 186 EVIIAKDEVAHTVTESRVL-QNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRE 244
Query: 189 RRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPE 248
R F E RARFY AE+ SA+ YLHS +++YRD+K EN++LD GH+ +TDFGLCKEG+
Sbjct: 245 RVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDG 304
Query: 249 DTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILH 308
T TFCGTPEYLAPEVL Y RAVDWW LG V+YEM+ G PFY+QD +++E IL
Sbjct: 305 ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILM 364
Query: 309 QPLQIPGGRTVAACDLLQSLLHKDQRQRL-GSKADFLEIKNHVFFSPINWDDLYHKRLTP 367
+ ++ P + A LL LL KD +QRL G +D E+ H FF INW D+ K+L P
Sbjct: 365 EEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLP 424
Query: 368 PFNPNVTGPADLKHFDPEFTQEAVS 392
PF P VT D ++FD EFT ++++
Sbjct: 425 PFKPQVTSEVDTRYFDDEFTAQSIT 449
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 333 bits (854), Expect = 2e-91
Identities = 168/331 (50%), Positives = 224/331 (67%), Gaps = 8/331 (2%)
Query: 66 AGTPSPQPSRANGNINLGPSANPNAQPT--DFDFLKVIGKGNYGKVLLAKRKSDGAFYAV 123
+G+PS ++L A P + T +F++LK++GKG +GKV+L K K+ G +YA+
Sbjct: 122 SGSPSDNSGAEEMEVSL---AKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAM 178
Query: 124 KVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFF 183
K+L+K+ I+ K E +H + E VL +N RHPFL L+YSFQT ++L FV++Y NGGELFF
Sbjct: 179 KILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFF 237
Query: 184 HLQRERRFLEPRARFYAAEVASAIGYLHS-LNIIYRDLKPENILLDCQGHVVLTDFGLCK 242
HL RER F E RARFY AE+ SA+ YLHS N++YRDLK EN++LD GH+ +TDFGLCK
Sbjct: 238 HLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK 297
Query: 243 EGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQM 302
EG++ T TFCGTPEYLAPEVL Y RAVDWW LG V+YEM+ G PFY+QD ++
Sbjct: 298 EGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 357
Query: 303 YENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRL-GSKADFLEIKNHVFFSPINWDDLY 361
+E IL + ++ P A LL LL KD +QRL G D EI H FF+ I W +Y
Sbjct: 358 FELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVY 417
Query: 362 HKRLTPPFNPNVTGPADLKHFDPEFTQEAVS 392
K+L+PPF P VT D ++FD EFT + ++
Sbjct: 418 EKKLSPPFKPQVTSETDTRYFDEEFTAQMIT 448
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 333 bits (854), Expect = 2e-91
Identities = 168/331 (50%), Positives = 224/331 (67%), Gaps = 8/331 (2%)
Query: 66 AGTPSPQPSRANGNINLGPSANPNAQPT--DFDFLKVIGKGNYGKVLLAKRKSDGAFYAV 123
+G+PS ++L A P + T +F++LK++GKG +GKV+L K K+ G +YA+
Sbjct: 122 SGSPSDNSGAEEMEVSL---AKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAM 178
Query: 124 KVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFF 183
K+L+K+ I+ K E +H + E VL +N RHPFL L+YSFQT ++L FV++Y NGGELFF
Sbjct: 179 KILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFF 237
Query: 184 HLQRERRFLEPRARFYAAEVASAIGYLHS-LNIIYRDLKPENILLDCQGHVVLTDFGLCK 242
HL RER F E RARFY AE+ SA+ YLHS N++YRDLK EN++LD GH+ +TDFGLCK
Sbjct: 238 HLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK 297
Query: 243 EGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQM 302
EG++ T TFCGTPEYLAPEVL Y RAVDWW LG V+YEM+ G PFY+QD ++
Sbjct: 298 EGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 357
Query: 303 YENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRL-GSKADFLEIKNHVFFSPINWDDLY 361
+E IL + ++ P A LL LL KD +QRL G D EI H FF+ I W +Y
Sbjct: 358 FELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVY 417
Query: 362 HKRLTPPFNPNVTGPADLKHFDPEFTQEAVS 392
K+L+PPF P VT D ++FD EFT + ++
Sbjct: 418 EKKLSPPFKPQVTSETDTRYFDEEFTAQMIT 448
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 333 bits (854), Expect = 2e-91
Identities = 168/331 (50%), Positives = 224/331 (67%), Gaps = 8/331 (2%)
Query: 66 AGTPSPQPSRANGNINLGPSANPNAQPT--DFDFLKVIGKGNYGKVLLAKRKSDGAFYAV 123
+G+PS ++L A P + T +F++LK++GKG +GKV+L K K+ G +YA+
Sbjct: 122 SGSPSDNSGAEEMEVSL---AKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAM 178
Query: 124 KVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFF 183
K+L+K+ I+ K E +H + E VL +N RHPFL L+YSFQT ++L FV++Y NGGELFF
Sbjct: 179 KILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFF 237
Query: 184 HLQRERRFLEPRARFYAAEVASAIGYLHS-LNIIYRDLKPENILLDCQGHVVLTDFGLCK 242
HL RER F E RARFY AE+ SA+ YLHS N++YRDLK EN++LD GH+ +TDFGLCK
Sbjct: 238 HLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK 297
Query: 243 EGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQM 302
EG++ T TFCGTPEYLAPEVL Y RAVDWW LG V+YEM+ G PFY+QD ++
Sbjct: 298 EGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 357
Query: 303 YENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRL-GSKADFLEIKNHVFFSPINWDDLY 361
+E IL + ++ P A LL LL KD +QRL G D EI H FF+ I W +Y
Sbjct: 358 FELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVY 417
Query: 362 HKRLTPPFNPNVTGPADLKHFDPEFTQEAVS 392
K+L+PPF P VT D ++FD EFT + ++
Sbjct: 418 EKKLSPPFKPQVTSETDTRYFDEEFTAQMIT 448
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 303 bits (776), Expect = 2e-82
Identities = 160/376 (42%), Positives = 230/376 (61%), Gaps = 27/376 (7%)
Query: 48 LPVPPELPDHCYRMNSSPAGTPSP-QPSRANGNINLGPS-----------ANPNAQPTDF 95
LP P +P M+S A T P PS +G A+ + DF
Sbjct: 195 LPQEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDF 254
Query: 96 DFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPF 155
D L+VIG+G+Y KVLL + K YA+KV++K+ + ++ + E+ V + HPF
Sbjct: 255 DLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPF 314
Query: 156 LVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNI 215
LVGL FQT +L+FV++YVNGG+L FH+QR+R+ E ARFY+AE++ A+ YLH I
Sbjct: 315 LVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGI 374
Query: 216 IYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAV 275
IYRDLK +N+LLD +GH+ LTD+G+CKEG+ P DTTSTFCGTP Y+APE+LR E Y +V
Sbjct: 375 IYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSV 434
Query: 276 DWWCLGAVLYEMLHGLPPF----YSQDVSQ-----MYENILHQPLQIPGGRTVAACDLLQ 326
DWW LG +++EM+ G PF S + Q +++ IL + ++IP +V A +L+
Sbjct: 435 DWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLK 494
Query: 327 SLLHKDQRQRLG--SKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDP 384
S L+KD ++RLG + F +I+ H FF ++WD + K++ PPF PN++G L +FD
Sbjct: 495 SFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDS 554
Query: 385 EFTQEAVSKSIGCTPD 400
+FT E V TPD
Sbjct: 555 QFTNEPVQ----LTPD 566
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 302 bits (774), Expect = 3e-82
Identities = 158/344 (45%), Positives = 221/344 (64%), Gaps = 13/344 (3%)
Query: 79 NINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSD---GAFYAVKVLQKKSILKK- 134
++N+GP P F+ L+V+GKG YGKV ++ G YA+KVL+K I++
Sbjct: 54 SVNVGPE---RIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNA 110
Query: 135 KEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEP 194
K+ +H AER++L ++V+HPF+V L Y+FQT KLY +L+ ++GGELF HL+RE FLE
Sbjct: 111 KDTAHTRAERNIL-ESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLED 169
Query: 195 RARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTF 254
A FY AE+ A+G+LHS IIYRDLKPENI+L QGH+ LTDFGLCKE + T TF
Sbjct: 170 TACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTF 229
Query: 255 CGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIP 314
CGT EY+APE+L + ++RAVDWW LGA++Y+ML G PPF +++ + + I+ L +P
Sbjct: 230 CGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALP 289
Query: 315 GGRTVAACDLLQSLLHKDQRQRL-GSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNV 373
T A DL++ L ++ QR+ G D +++ H FF +NWDDL R+ PPF P +
Sbjct: 290 PYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCL 349
Query: 374 TGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 417
D+ FD FT++ S PD A S A+ AFLGF+Y
Sbjct: 350 QSEEDVSQFDTRFTRQTPVDS----PDDTALSESANQAFLGFTY 389
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 299 bits (765), Expect = 4e-81
Identities = 156/344 (45%), Positives = 222/344 (64%), Gaps = 13/344 (3%)
Query: 79 NINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKR---KSDGAFYAVKVLQKKSILKK- 134
++N GP +P F+ L+V+GKG YGKV ++ + G +A+KVL+K I++
Sbjct: 78 SVNRGPE---KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNA 134
Query: 135 KEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEP 194
K+ +H AER++L + V+HPF+V L Y+FQT KLY +L+Y++GGELF L+RE F+E
Sbjct: 135 KDTAHTKAERNIL-EEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMED 193
Query: 195 RARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTF 254
A FY AE++ A+G+LH IIYRDLKPENI+L+ QGHV LTDFGLCKE + T TF
Sbjct: 194 TACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTF 253
Query: 255 CGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIP 314
CGT EY+APE+L + ++RAVDWW LGA++Y+ML G PPF ++ + + IL L +P
Sbjct: 254 CGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLP 313
Query: 315 GGRTVAACDLLQSLLHKDQRQRLGS-KADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNV 373
T A DLL+ LL ++ RLG+ D E++ H FF INW++L +++ PPF P +
Sbjct: 314 PYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLL 373
Query: 374 TGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 417
D+ FD +FT++ S PD S A+ FLGF+Y
Sbjct: 374 QSEEDVSQFDSKFTRQTPVDS----PDDSTLSESANQVFLGFTY 413
>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 295 bits (756), Expect = 4e-80
Identities = 151/334 (45%), Positives = 215/334 (64%), Gaps = 14/334 (4%)
Query: 94 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 153
DFD ++VIG+G+Y KVLL + K + YA+KV++K+ + ++ + E+ V + +
Sbjct: 68 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
Query: 154 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 213
PFLVGL FQT +L+ V++YVNGG+L FH+QR+R+ E ARFYAAE+ A+ +LH
Sbjct: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
Query: 214 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDR 273
IIYRDLK +N+LLD GH+ LTD+G+CKEG+ P DTTSTFCGTP Y+APE+LR E Y
Sbjct: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
Query: 274 AVDWWCLGAVLYEMLHGLPPF----YSQDVS---QMYENILHQPLQIPGGRTVAACDLLQ 326
+VDWW LG +++EM+ G PF + D++ +++ IL +P++IP +V A +L+
Sbjct: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
Query: 327 SLLHKDQRQRLGSK--ADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDP 384
L+KD ++RLG + F +IK+H FF I+WD L K+ PPF P +T L +FD
Sbjct: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
Query: 385 EFTQEAVSKSIGCTPDTV-ASSSGASSAFLGFSY 417
+FT E V TPD A S F GF Y
Sbjct: 368 QFTSEPVQ----LTPDDEDAIKRIDQSEFEGFEY 397
>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 295 bits (756), Expect = 4e-80
Identities = 151/334 (45%), Positives = 215/334 (64%), Gaps = 14/334 (4%)
Query: 94 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 153
DFD ++VIG+G+Y KVLL + K + YA+KV++K+ + ++ + E+ V + +
Sbjct: 68 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
Query: 154 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 213
PFLVGL FQT +L+ V++YVNGG+L FH+QR+R+ E ARFYAAE+ A+ +LH
Sbjct: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
Query: 214 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDR 273
IIYRDLK +N+LLD GH+ LTD+G+CKEG+ P DTTSTFCGTP Y+APE+LR E Y
Sbjct: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
Query: 274 AVDWWCLGAVLYEMLHGLPPF----YSQDVS---QMYENILHQPLQIPGGRTVAACDLLQ 326
+VDWW LG +++EM+ G PF + D++ +++ IL +P++IP +V A +L+
Sbjct: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
Query: 327 SLLHKDQRQRLGSK--ADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDP 384
L+KD ++RLG + F +IK+H FF I+WD L K+ PPF P +T L +FD
Sbjct: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
Query: 385 EFTQEAVSKSIGCTPDTV-ASSSGASSAFLGFSY 417
+FT E V TPD A S F GF Y
Sbjct: 368 QFTSEPVQ----LTPDDEDAIKRIDQSEFEGFEY 397
>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
Length = 592
Score = 295 bits (756), Expect = 4e-80
Identities = 151/334 (45%), Positives = 215/334 (64%), Gaps = 14/334 (4%)
Query: 94 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 153
DFD ++VIG+G+Y KVLL + K + YA+KV++K+ + ++ + E+ V + +
Sbjct: 251 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 310
Query: 154 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 213
PFLVGL FQT +L+ V++YVNGG+L FH+QR+R+ E ARFYAAE+ A+ +LH
Sbjct: 311 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 370
Query: 214 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDR 273
IIYRDLK +N+LLD GH+ LTD+G+CKEG+ P DTTSTFCGTP Y+APE+LR E Y
Sbjct: 371 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 430
Query: 274 AVDWWCLGAVLYEMLHGLPPF----YSQDVS---QMYENILHQPLQIPGGRTVAACDLLQ 326
+VDWW LG +++EM+ G PF + D++ +++ IL +P++IP +V A +L+
Sbjct: 431 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 490
Query: 327 SLLHKDQRQRLGSK--ADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDP 384
L+KD ++RLG + F +IK+H FF I+WD L K+ PPF P +T L +FD
Sbjct: 491 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 550
Query: 385 EFTQEAVSKSIGCTPDTV-ASSSGASSAFLGFSY 417
+FT E V TPD A S F GF Y
Sbjct: 551 QFTSEPVQ----LTPDDEDAIKRIDQSEFEGFEY 580
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 293 bits (750), Expect = 2e-79
Identities = 157/367 (42%), Positives = 225/367 (61%), Gaps = 12/367 (3%)
Query: 59 YRMNSSPAGT-PSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSD 117
+R SSP G SP NG + G + +F+F+KV+GKG++GKV+LA+ K
Sbjct: 376 HRAASSPDGQLMSPGE---NGEVRQGQAKRLGLD--EFNFIKVLGKGSFGKVMLAELKGK 430
Query: 118 GAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVN 177
YAVKVL+K IL+ + M E+ +L +HP+L L FQT ++L+FV++YVN
Sbjct: 431 DEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVN 490
Query: 178 GGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTD 237
GG+L F +QR R+F EPR+RFYAAEV SA+ +LH +IYRDLK +NILLD +GH L D
Sbjct: 491 GGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLAD 550
Query: 238 FGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQ 297
FG+CKEG+ TT+TFCGTP+Y+APE+L++ Y +VDWW LG ++YEM+ G PPF +
Sbjct: 551 FGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEAD 610
Query: 298 DVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLG---SKADFLEIKNHVFFSP 354
+ ++E+ILH + P + A +L++ + K+ +RLG S+ IK H FF
Sbjct: 611 NEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKE 670
Query: 355 INWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLG 414
I+W L K++ PPF P + D+ +FD +FT+E + + D F G
Sbjct: 671 IDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTRE---EPVLTLVDEAIVKQINQEEFKG 727
Query: 415 FSYAPED 421
FSY ED
Sbjct: 728 FSYFGED 734
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 289 bits (739), Expect = 4e-78
Identities = 145/318 (45%), Positives = 208/318 (65%), Gaps = 3/318 (0%)
Query: 74 SRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILK 133
S GN +G +++ +F+F++V+GKG++GKV+LA+ K G YAVKVL+K IL+
Sbjct: 335 SSKEGN-GIGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQ 393
Query: 134 KKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLE 193
+ M E+ +L HPFL L FQTP++L+FV+++VNGG+L FH+Q+ RRF E
Sbjct: 394 DDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDE 453
Query: 194 PRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTST 253
RARFYAAE+ SA+ +LH IIYRDLK +N+LLD +GH L DFG+CKEG+ TT+T
Sbjct: 454 ARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTAT 513
Query: 254 FCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQI 313
FCGTP+Y+APE+L++ Y AVDWW +G +LYEML G PF +++ ++E IL+ +
Sbjct: 514 FCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVY 573
Query: 314 PGGRTVAACDLLQSLLHKDQRQRLGSKADFLE--IKNHVFFSPINWDDLYHKRLTPPFNP 371
P A +L+S + K+ RLGS E I H FF I+W L H+++ PPF P
Sbjct: 574 PTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRP 633
Query: 372 NVTGPADLKHFDPEFTQE 389
+ D+ +FDP+F +E
Sbjct: 634 RIKSREDVSNFDPDFIKE 651
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 284 bits (727), Expect = 9e-77
Identities = 149/368 (40%), Positives = 222/368 (60%), Gaps = 10/368 (2%)
Query: 60 RMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGA 119
RM S + PSP PS + ++ +DF FL V+GKG++GKV+LA+R+
Sbjct: 316 RMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDE 375
Query: 120 FYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHP-----FLVGLRYSFQTPEKLYFVLD 174
YA+K+L+K I++ + + E+ VL R P FL L +FQTP++LYFV++
Sbjct: 376 LYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVME 435
Query: 175 YVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVV 234
YV GG+L +H+Q+ +F EP A FYAAE+A + +LH+ IIYRDLK +N++LD +GH+
Sbjct: 436 YVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIK 495
Query: 235 LTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPF 294
+TDFG+CKE V P TT TFCGTP+Y+APE++ +PY ++VDWW G +LYEML G PPF
Sbjct: 496 ITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPF 555
Query: 295 YSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKAD-FLEIKNHVFFS 353
+D ++++ I+ Q + P + A + + L K +RLGS D I+ H FF
Sbjct: 556 DGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFR 615
Query: 354 PINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFL 413
I+W+ L + PPF P G + ++FD FT+ A + + PD + +S + F
Sbjct: 616 WIDWERLERLEIPPPFRPRPCGRSG-ENFDKFFTRAAPALT---PPDRLVLASIDQADFQ 671
Query: 414 GFSYAPED 421
GF+Y D
Sbjct: 672 GFTYVNPD 679
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 283 bits (725), Expect = 2e-76
Identities = 163/404 (40%), Positives = 226/404 (55%), Gaps = 25/404 (6%)
Query: 27 WCLKPWMGGADPPTPTLSCLLLPVPPELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSA 86
W L PW+ P + + L +P P S P + + +
Sbjct: 13 WALIPWLPRKQRPRISQTSLPVPGP----------GSGPQRDSDEGVLKEISITHHVKAG 62
Query: 87 NPNAQPTDFDFLKVIGKGNYGKVLLAK---RKSDGAFYAVKVLQKKSILKKKEQSHIMAE 143
+ A P+ F+ LKV+G+G++GKV L + R G YA+KVL KK+ LK +++ E
Sbjct: 63 SEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTKME 121
Query: 144 RSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEV 203
R +L +V HPF+V L Y+FQT KLY +LD++ GG+LF L +E F E +FY AE+
Sbjct: 122 RDILA-DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAEL 180
Query: 204 ASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAP 263
A + +LHSL IIYRDLKPENILLD +GH+ LTDFGL KE ++ E +FCGT EY+AP
Sbjct: 181 ALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAP 240
Query: 264 EVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACD 323
EV+ ++ + + DWW G +++EML G PF +D + IL L +P + A
Sbjct: 241 EVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQS 300
Query: 324 LLQSLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHF 382
LL++L ++ RLGS D EIK HVF+S I+W+ LY + + PPF P V P D +F
Sbjct: 301 LLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYF 360
Query: 383 DPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAP----EDD 422
D EFT S G P S+GA F GFS+ EDD
Sbjct: 361 DTEFTSRTPKDSPGIPP-----SAGAHQLFRGFSFVATGLMEDD 399
Score = 124 bits (312), Expect = 1e-28
Identities = 83/253 (32%), Positives = 127/253 (50%), Gaps = 18/253 (7%)
Query: 99 KVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVG 158
+ IG G+Y + K+ YAVKV+ K K++ S E +LL+ +HP ++
Sbjct: 431 ETIGVGSYSECKRCVHKATNMEYAVKVIDKS----KRDPSE---EIEILLRYGQHPNIIT 483
Query: 159 LRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYR 218
L+ + + +Y V + + GGEL + R++ F E A F + + YLHS +++R
Sbjct: 484 LKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 543
Query: 219 DLKPENIL-LDCQGH---VVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRA 274
DLKP NIL +D G+ + + DFG K+ T C T ++APEVL+++ YD
Sbjct: 544 DLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEG 603
Query: 275 VDWWCLGAVLYEMLHGLPPFY---SQDVSQMYENILHQPLQIPGGR----TVAACDLLQS 327
D W LG +LY ML G PF S ++ I + GG + A DL+
Sbjct: 604 CDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSK 663
Query: 328 LLHKDQRQRLGSK 340
+LH D QRL +K
Sbjct: 664 MLHVDPHQRLTAK 676
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 283 bits (724), Expect = 2e-76
Identities = 148/379 (39%), Positives = 221/379 (58%), Gaps = 13/379 (3%)
Query: 48 LPVPPELPDHCYRMNSS------PAGTPSPQPSRANGNINLGPSANPNAQP-TDFDFLKV 100
+PVPPE + + GT P+ N + N + TDF+FL V
Sbjct: 288 VPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMV 347
Query: 101 IGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLR 160
+GKG++GKV+L++RK YAVK+L+K +++ + M E+ VL + PFL L
Sbjct: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407
Query: 161 YSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDL 220
FQT ++LYFV++YVNGG+L +H+Q+ RF EP A FYAAE+A + +L S IIYRDL
Sbjct: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467
Query: 221 KPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCL 280
K +N++LD +GH+ + DFG+CKE + TT TFCGTP+Y+APE++ +PY ++VDWW
Sbjct: 468 KLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAF 527
Query: 281 GAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSK 340
G +LYEML G PF +D +++++I+ + P + A + + L+ K +RLG
Sbjct: 528 GVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCG 587
Query: 341 AD-FLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTP 399
+ +IK H FF I+W+ L K + PP+ P D +FD EFT++ V TP
Sbjct: 588 PEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVE----LTP 643
Query: 400 -DTVASSSGASSAFLGFSY 417
D + + + F GFSY
Sbjct: 644 TDKLFIMNLDQNEFAGFSY 662
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 281 bits (719), Expect = 8e-76
Identities = 153/346 (44%), Positives = 210/346 (60%), Gaps = 15/346 (4%)
Query: 85 SANPNAQPTDFDFLKVIGKGNYGKVLLAK---RKSDGAFYAVKVLQKKSILKKKEQSHIM 141
+ + A P+ F+ LKV+G+G++GKV L + R G YA+KVL KK+ LK +++
Sbjct: 52 AGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTK 110
Query: 142 AERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAA 201
ER +L +V HPF+V L Y+FQT KLY +LD++ GG+LF L +E F E +FY A
Sbjct: 111 MERDILA-DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 169
Query: 202 EVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYL 261
E+A + +LHSL IIYRDLKPENILLD +GH+ LTDFGL KE ++ E +FCGT EY+
Sbjct: 170 ELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYM 229
Query: 262 APEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAA 321
APEV+ ++ + + DWW G +++EML G PF +D + IL L +P + A
Sbjct: 230 APEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEA 289
Query: 322 CDLLQSLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLK 380
LL++L ++ RLGS D EIK HVF+S I+W+ LY + + PPF P V P D
Sbjct: 290 QSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTF 349
Query: 381 HFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAP----EDD 422
+FD EFT S G P S+GA F GFS+ EDD
Sbjct: 350 YFDTEFTSRTPKDSPGIPP-----SAGAHQLFRGFSFVATGLMEDD 390
Score = 124 bits (312), Expect = 1e-28
Identities = 83/253 (32%), Positives = 127/253 (50%), Gaps = 18/253 (7%)
Query: 99 KVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVG 158
+ IG G+Y + K+ YAVKV+ K K++ S E +LL+ +HP ++
Sbjct: 422 ETIGVGSYSECKRCVHKATNMEYAVKVIDKS----KRDPSE---EIEILLRYGQHPNIIT 474
Query: 159 LRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYR 218
L+ + + +Y V + + GGEL + R++ F E A F + + YLHS +++R
Sbjct: 475 LKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 534
Query: 219 DLKPENIL-LDCQGH---VVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRA 274
DLKP NIL +D G+ + + DFG K+ T C T ++APEVL+++ YD
Sbjct: 535 DLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEG 594
Query: 275 VDWWCLGAVLYEMLHGLPPFY---SQDVSQMYENILHQPLQIPGGR----TVAACDLLQS 327
D W LG +LY ML G PF S ++ I + GG + A DL+
Sbjct: 595 CDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSK 654
Query: 328 LLHKDQRQRLGSK 340
+LH D QRL +K
Sbjct: 655 MLHVDPHQRLTAK 667
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 279 bits (714), Expect = 3e-75
Identities = 144/368 (39%), Positives = 221/368 (60%), Gaps = 12/368 (3%)
Query: 53 ELPDHCYRMNSSPAGTP--SPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVL 110
EL + PAG SP R + NL + TDF+FL V+GKG++GKV+
Sbjct: 300 ELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLD-----RVKLTDFNFLMVLGKGSFGKVM 354
Query: 111 LAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLY 170
LA RK YA+K+L+K +++ + M E+ VL + PFL L FQT ++LY
Sbjct: 355 LADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLY 414
Query: 171 FVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQ 230
FV++YVNGG+L +H+Q+ +F EP+A FYAAE++ + +LH IIYRDLK +N++LD +
Sbjct: 415 FVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSE 474
Query: 231 GHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHG 290
GH+ + DFG+CKE + TT TFCGTP+Y+APE++ +PY ++VDWW G +LYEML G
Sbjct: 475 GHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAG 534
Query: 291 LPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKAD-FLEIKNH 349
PPF +D +++++I+ + P + A + + L+ K +RLG + +++ H
Sbjct: 535 QPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREH 594
Query: 350 VFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGAS 409
FF I+W+ L ++ + PPF P V G ++FD FT+ + + PD + ++
Sbjct: 595 AFFRRIDWEKLENREIQPPFKPKVCGKG-AENFDKFFTR---GQPVLTPPDQLVIANIDQ 650
Query: 410 SAFLGFSY 417
S F GFSY
Sbjct: 651 SDFEGFSY 658
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 278 bits (711), Expect = 7e-75
Identities = 150/338 (44%), Positives = 207/338 (61%), Gaps = 11/338 (3%)
Query: 90 AQPTDFDFLKVIGKGNYGKVLLAKRKSDG---AFYAVKVLQKKSILKKKEQSHIMAERSV 146
A P+ F+ LKV+G+G++GKV L K+ S YA+KVL KK+ LK +++ ER +
Sbjct: 63 ADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVL-KKATLKVRDRVRTKMERDI 121
Query: 147 LLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASA 206
L++ V HPF+V L Y+FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 122 LVE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 180
Query: 207 IGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVL 266
+ +LHSL IIYRDLKPENILLD +GH+ LTDFGL KE ++ E +FCGT EY+APEV+
Sbjct: 181 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV 240
Query: 267 RKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQ 326
+ + ++ DWW G +++EML G PF +D + IL L +P + A LL+
Sbjct: 241 NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLR 300
Query: 327 SLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPE 385
L ++ RLG+ D + EIK H FFS I+W+ LY + + PPF P P D +FDPE
Sbjct: 301 MLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPE 360
Query: 386 FTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPEDDD 423
FT + S G P S+ A F GFS+ D
Sbjct: 361 FTAKTPKDSPGIPP-----SANAHQLFRGFSFVAITSD 393
Score = 114 bits (286), Expect = 1e-25
Identities = 83/284 (29%), Positives = 137/284 (48%), Gaps = 24/284 (8%)
Query: 101 IGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLR 160
IG G+Y K+ +AVK++ K K++ + E +LL+ +HP ++ L+
Sbjct: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKS----KRDPTE---EIEILLRYGQHPNIITLK 480
Query: 161 YSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDL 220
+ + +Y V + + GGEL + R++ F E A + + YLH+ +++RDL
Sbjct: 481 DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL 540
Query: 221 KPENIL-LDCQGH---VVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVD 276
KP NIL +D G+ + + DFG K+ T C T ++APEVL+++ YD A D
Sbjct: 541 KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACD 600
Query: 277 WWCLGAVLYEMLHGLPPFYS---QDVSQMYENILHQPLQIPGGR----TVAACDLLQSLL 329
W LG +LY ML G PF + ++ I + GG + A DL+ +L
Sbjct: 601 IWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKML 660
Query: 330 HKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNV 373
H D QRL + + H + ++WD L +L P++
Sbjct: 661 HVDPHQRLTAAL----VLRHPWI--VHWDQLPQYQLNRQDAPHL 698
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 278 bits (710), Expect = 9e-75
Identities = 149/332 (44%), Positives = 206/332 (62%), Gaps = 11/332 (3%)
Query: 90 AQPTDFDFLKVIGKGNYGKVLLAKR---KSDGAFYAVKVLQKKSILKKKEQSHIMAERSV 146
A P+ F+ LKV+G+G+YGKV L ++ G YA+KVL KK+ LK +++ ER +
Sbjct: 62 ADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL-KKATLKVRDRVRSKMERDI 120
Query: 147 LLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASA 206
L + V HPF+V L Y+FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 121 LAE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 179
Query: 207 IGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVL 266
+ +LHSL IIYRDLKPENILLD +GH+ +TDFGL KE ++ + +FCGT EY+APEV+
Sbjct: 180 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 239
Query: 267 RKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQ 326
+ + ++ DWW G +++EML G PF +D + IL L +P + A LL+
Sbjct: 240 NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLR 299
Query: 327 SLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPE 385
+L ++ RLG+ D + EIK H FF I+W+ LY K + PPF P V P D HFDPE
Sbjct: 300 ALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPE 359
Query: 386 FTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 417
FT + S G P S+ A F GFS+
Sbjct: 360 FTARTPTDSPGVPP-----SANAHHLFRGFSF 386
Score = 119 bits (298), Expect = 5e-27
Identities = 79/254 (31%), Positives = 125/254 (49%), Gaps = 18/254 (7%)
Query: 95 FDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHP 154
++ + IG G+Y K+ YAVK++ K K++ S E +LL+ +HP
Sbjct: 423 YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKS----KRDPSE---EIEILLRYGQHP 475
Query: 155 FLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLN 214
++ L+ + + +Y V++ + GGEL + R+R F E A + + YLHS
Sbjct: 476 NIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQG 535
Query: 215 IIYRDLKPENILLDCQG----HVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEP 270
+++RDLKP NIL + + + DFG K+ T C T ++APEVL+++
Sbjct: 536 VVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQG 595
Query: 271 YDRAVDWWCLGAVLYEMLHGLPPFYS---QDVSQMYENILHQPLQIPGGR----TVAACD 323
YD A D W LG +LY ML G PF + ++ I + GG + AA D
Sbjct: 596 YDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKD 655
Query: 324 LLQSLLHKDQRQRL 337
++ +LH D QRL
Sbjct: 656 VVSKMLHVDPHQRL 669
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.139 0.440
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,856,063
Number of Sequences: 37866
Number of extensions: 1099265
Number of successful extensions: 6007
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 713
Number of HSP's successfully gapped in prelim test: 124
Number of HSP's that attempted gapping in prelim test: 3620
Number of HSP's gapped (non-prelim): 1105
length of query: 427
length of database: 18,247,518
effective HSP length: 105
effective length of query: 322
effective length of database: 14,271,588
effective search space: 4595451336
effective search space used: 4595451336
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.