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Search of human proteins with 20070380
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20070380 neuregulin 4 [Homo sapiens]
(115 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20070380 neuregulin 4 [Homo sapiens] 245 6e-66
gi|7669528 neuregulin 2 isoform 2 [Homo sapiens] 51 2e-07
gi|7669532 neuregulin 2 isoform 4 [Homo sapiens] 50 4e-07
gi|4557567 epiregulin preproprotein [Homo sapiens] 49 7e-07
gi|66730481 neuregulin 3 [Homo sapiens] 49 9e-07
gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens] 49 1e-06
gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens] 49 1e-06
gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens] 49 1e-06
gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens] 48 1e-06
gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens] 48 1e-06
gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens] 48 1e-06
gi|61806622 epithelial mitogen [Homo sapiens] 47 2e-06
gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens] 46 6e-06
gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens] 46 6e-06
gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens] 46 6e-06
gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens] 46 6e-06
gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens] 46 7e-06
gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens] 46 7e-06
gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens] 46 7e-06
gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens] 46 7e-06
gi|7669530 neuregulin 2 isoform 3 [Homo sapiens] 46 7e-06
gi|4758832 neuregulin 2 isoform 1 [Homo sapiens] 46 7e-06
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 43 5e-05
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa... 43 6e-05
gi|93102379 low density lipoprotein-related protein 1B precursor... 42 1e-04
gi|153791414 transforming growth factor, alpha isoform 2 [Homo s... 41 2e-04
gi|4507461 transforming growth factor, alpha isoform 1 [Homo sap... 41 2e-04
gi|24041035 notch 2 preproprotein [Homo sapiens] 39 9e-04
gi|4502199 amphiregulin preproprotein [Homo sapiens] 39 9e-04
gi|113415639 PREDICTED: amphiregulin B [Homo sapiens] 39 9e-04
>gi|20070380 neuregulin 4 [Homo sapiens]
Length = 115
Score = 245 bits (625), Expect = 6e-66
Identities = 115/115 (100%), Positives = 115/115 (100%)
Query: 1 MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSN 60
MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSN
Sbjct: 1 MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSN 60
Query: 61 LFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSHEQH 115
LFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSHEQH
Sbjct: 61 LFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSHEQH 115
>gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]
Length = 844
Score = 51.2 bits (121), Expect = 2e-07
Identities = 26/76 (34%), Positives = 38/76 (50%), Gaps = 4/76 (5%)
Query: 5 HEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEV----FLPGSSIQTKSN 60
H C + KS+C+NGG+CY I I C+C YTG RC++ F + K
Sbjct: 341 HARKCNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQQFAMVNFSKAEELYQKRV 400
Query: 61 LFEAFVALAVLVTLII 76
L + +A+LV I+
Sbjct: 401 LTITGICVALLVVGIV 416
>gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]
Length = 852
Score = 50.1 bits (118), Expect = 4e-07
Identities = 23/60 (38%), Positives = 31/60 (51%)
Query: 5 HEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSNLFEA 64
H C + KS+C+NGG+CY I I C+C YTG RC++ + S L EA
Sbjct: 341 HARKCNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQQFAMVNFSKHLGFELKEA 400
>gi|4557567 epiregulin preproprotein [Homo sapiens]
Length = 169
Score = 49.3 bits (116), Expect = 7e-07
Identities = 21/76 (27%), Positives = 37/76 (48%), Gaps = 1/76 (1%)
Query: 9 CGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSNLFEAFVAL 68
C +CL+G Y++ + +CRC YTG RCE FL +K + + +
Sbjct: 68 CSSDMNGYCLHGQCIYLVD-MSQNYCRCEVGYTGVRCEHFFLTVHQPLSKEYVALTVILI 126
Query: 69 AVLVTLIIGAFYFLCR 84
+ + ++G+ Y+ CR
Sbjct: 127 ILFLITVVGSTYYFCR 142
>gi|66730481 neuregulin 3 [Homo sapiens]
Length = 696
Score = 48.9 bits (115), Expect = 9e-07
Identities = 22/51 (43%), Positives = 31/51 (60%), Gaps = 3/51 (5%)
Query: 3 TDHEEPCGPSHKSFCLNGGLCYVIPTIPS--PFCRCVENYTGARCEEVFLP 51
++H +PC ++CLN G C+VI T+ CRC E Y G RC++ FLP
Sbjct: 284 SEHFKPCRDKDLAYCLNDGECFVIETLTGSHKHCRCKEGYQGVRCDQ-FLP 333
>gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens]
Length = 308
Score = 48.5 bits (114), Expect = 1e-06
Identities = 19/48 (39%), Positives = 28/48 (58%), Gaps = 3/48 (6%)
Query: 3 TDHEEPCGPSHKSFCLNGGLCYVIPTIPSP---FCRCVENYTGARCEE 47
T H C K+FC+NGG C+++ + +P C+C +TGARC E
Sbjct: 22 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTE 69
>gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens]
Length = 640
Score = 48.5 bits (114), Expect = 1e-06
Identities = 19/48 (39%), Positives = 28/48 (58%), Gaps = 3/48 (6%)
Query: 3 TDHEEPCGPSHKSFCLNGGLCYVIPTIPSP---FCRCVENYTGARCEE 47
T H C K+FC+NGG C+++ + +P C+C +TGARC E
Sbjct: 176 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTE 223
>gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens]
Length = 462
Score = 48.5 bits (114), Expect = 1e-06
Identities = 19/48 (39%), Positives = 28/48 (58%), Gaps = 3/48 (6%)
Query: 3 TDHEEPCGPSHKSFCLNGGLCYVIPTIPSP---FCRCVENYTGARCEE 47
T H C K+FC+NGG C+++ + +P C+C +TGARC E
Sbjct: 176 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTE 223
>gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens]
Length = 459
Score = 48.1 bits (113), Expect = 1e-06
Identities = 30/120 (25%), Positives = 53/120 (44%), Gaps = 12/120 (10%)
Query: 3 TDHEEPCGPSHKSFCLNGGLCYVIPTIPSP---FCRCVENYTGARCEEV----FLPGSSI 55
T H C K+FC+NGG C+++ + +P C+C +TG RC+ F +
Sbjct: 176 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEEL 235
Query: 56 QTKSNLFEAFVALAVLVTLIIGAFYFL-----CRKGHFQRASSVQYDINLVETSSTSAHH 110
K L + +A+LV I+ + +K H + S++ + N + + HH
Sbjct: 236 YQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHH 295
>gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens]
Length = 420
Score = 48.1 bits (113), Expect = 1e-06
Identities = 30/120 (25%), Positives = 53/120 (44%), Gaps = 12/120 (10%)
Query: 3 TDHEEPCGPSHKSFCLNGGLCYVIPTIPSP---FCRCVENYTGARCEEV----FLPGSSI 55
T H C K+FC+NGG C+++ + +P C+C +TG RC+ F +
Sbjct: 176 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEEL 235
Query: 56 QTKSNLFEAFVALAVLVTLIIGAFYFL-----CRKGHFQRASSVQYDINLVETSSTSAHH 110
K L + +A+LV I+ + +K H + S++ + N + + HH
Sbjct: 236 YQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHH 295
>gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens]
Length = 637
Score = 48.1 bits (113), Expect = 1e-06
Identities = 30/120 (25%), Positives = 53/120 (44%), Gaps = 12/120 (10%)
Query: 3 TDHEEPCGPSHKSFCLNGGLCYVIPTIPSP---FCRCVENYTGARCEEV----FLPGSSI 55
T H C K+FC+NGG C+++ + +P C+C +TG RC+ F +
Sbjct: 176 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEEL 235
Query: 56 QTKSNLFEAFVALAVLVTLIIGAFYFL-----CRKGHFQRASSVQYDINLVETSSTSAHH 110
K L + +A+LV I+ + +K H + S++ + N + + HH
Sbjct: 236 YQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHH 295
>gi|61806622 epithelial mitogen [Homo sapiens]
Length = 133
Score = 47.4 bits (111), Expect = 2e-06
Identities = 22/71 (30%), Positives = 36/71 (50%), Gaps = 5/71 (7%)
Query: 9 CGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSNLFEAFVAL 68
C H S+C+NG C + CRC YTG RCE + L ++ + +E ++A+
Sbjct: 51 CLEDHNSYCINGA-CAFHHELEKAICRCFTGYTGERCEHLTLTSYAVDS----YEKYIAI 105
Query: 69 AVLVTLIIGAF 79
+ V L++ F
Sbjct: 106 GIGVGLLLSGF 116
>gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens]
Length = 590
Score = 46.2 bits (108), Expect = 6e-06
Identities = 30/128 (23%), Positives = 54/128 (42%), Gaps = 20/128 (15%)
Query: 3 TDHEEPCGPSHKSFCLNGGLCYVIPTIPSP---FCRCVENYTGARCEEV----------- 48
T H C K+FC+NGG C+++ + +P C+C +TG RC+
Sbjct: 121 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGI 180
Query: 49 -FLPGSSIQTKSNLFEAFVALAVLVTLIIGAFYFL-----CRKGHFQRASSVQYDINLVE 102
F+ + K L + +A+LV I+ + +K H + S++ + N +
Sbjct: 181 EFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMM 240
Query: 103 TSSTSAHH 110
+ HH
Sbjct: 241 NIANGPHH 248
>gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens]
Length = 624
Score = 46.2 bits (108), Expect = 6e-06
Identities = 30/128 (23%), Positives = 54/128 (42%), Gaps = 20/128 (15%)
Query: 3 TDHEEPCGPSHKSFCLNGGLCYVIPTIPSP---FCRCVENYTGARCEEV----------- 48
T H C K+FC+NGG C+++ + +P C+C +TG RC+
Sbjct: 155 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGI 214
Query: 49 -FLPGSSIQTKSNLFEAFVALAVLVTLIIGAFYFL-----CRKGHFQRASSVQYDINLVE 102
F+ + K L + +A+LV I+ + +K H + S++ + N +
Sbjct: 215 EFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMM 274
Query: 103 TSSTSAHH 110
+ HH
Sbjct: 275 NIANGPHH 282
>gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens]
Length = 607
Score = 46.2 bits (108), Expect = 6e-06
Identities = 30/128 (23%), Positives = 54/128 (42%), Gaps = 20/128 (15%)
Query: 3 TDHEEPCGPSHKSFCLNGGLCYVIPTIPSP---FCRCVENYTGARCEEV----------- 48
T H C K+FC+NGG C+++ + +P C+C +TG RC+
Sbjct: 138 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGI 197
Query: 49 -FLPGSSIQTKSNLFEAFVALAVLVTLIIGAFYFL-----CRKGHFQRASSVQYDINLVE 102
F+ + K L + +A+LV I+ + +K H + S++ + N +
Sbjct: 198 EFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMM 257
Query: 103 TSSTSAHH 110
+ HH
Sbjct: 258 NIANGPHH 265
>gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens]
Length = 645
Score = 46.2 bits (108), Expect = 6e-06
Identities = 30/128 (23%), Positives = 54/128 (42%), Gaps = 20/128 (15%)
Query: 3 TDHEEPCGPSHKSFCLNGGLCYVIPTIPSP---FCRCVENYTGARCEEV----------- 48
T H C K+FC+NGG C+++ + +P C+C +TG RC+
Sbjct: 176 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGI 235
Query: 49 -FLPGSSIQTKSNLFEAFVALAVLVTLIIGAFYFL-----CRKGHFQRASSVQYDINLVE 102
F+ + K L + +A+LV I+ + +K H + S++ + N +
Sbjct: 236 EFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMM 295
Query: 103 TSSTSAHH 110
+ HH
Sbjct: 296 NIANGPHH 303
>gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens]
Length = 207
Score = 45.8 bits (107), Expect = 7e-06
Identities = 17/47 (36%), Positives = 27/47 (57%), Gaps = 3/47 (6%)
Query: 3 TDHEEPCGPSHKSFCLNGGLCYVIPTIPSP---FCRCVENYTGARCE 46
T H C K+FC+NGG C+++ + +P C+C +TG RC+
Sbjct: 142 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQ 188
>gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens]
Length = 241
Score = 45.8 bits (107), Expect = 7e-06
Identities = 17/47 (36%), Positives = 27/47 (57%), Gaps = 3/47 (6%)
Query: 3 TDHEEPCGPSHKSFCLNGGLCYVIPTIPSP---FCRCVENYTGARCE 46
T H C K+FC+NGG C+++ + +P C+C +TG RC+
Sbjct: 176 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQ 222
>gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens]
Length = 296
Score = 45.8 bits (107), Expect = 7e-06
Identities = 17/47 (36%), Positives = 27/47 (57%), Gaps = 3/47 (6%)
Query: 3 TDHEEPCGPSHKSFCLNGGLCYVIPTIPSP---FCRCVENYTGARCE 46
T H C K+FC+NGG C+++ + +P C+C +TG RC+
Sbjct: 231 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQ 277
>gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens]
Length = 422
Score = 45.8 bits (107), Expect = 7e-06
Identities = 17/47 (36%), Positives = 27/47 (57%), Gaps = 3/47 (6%)
Query: 3 TDHEEPCGPSHKSFCLNGGLCYVIPTIPSP---FCRCVENYTGARCE 46
T H C K+FC+NGG C+++ + +P C+C +TG RC+
Sbjct: 357 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQ 403
>gi|7669530 neuregulin 2 isoform 3 [Homo sapiens]
Length = 858
Score = 45.8 bits (107), Expect = 7e-06
Identities = 18/43 (41%), Positives = 24/43 (55%)
Query: 5 HEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEE 47
H C + KS+C+NGG+CY I I C+C + G RC E
Sbjct: 341 HARKCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLE 383
>gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]
Length = 850
Score = 45.8 bits (107), Expect = 7e-06
Identities = 18/43 (41%), Positives = 24/43 (55%)
Query: 5 HEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEE 47
H C + KS+C+NGG+CY I I C+C + G RC E
Sbjct: 341 HARKCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLE 383
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 43.1 bits (100), Expect = 5e-05
Identities = 30/94 (31%), Positives = 44/94 (46%), Gaps = 12/94 (12%)
Query: 1 MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSN 60
+P + PC C++GG CY T P C+C YTG CE F G S T +
Sbjct: 4373 LPINLPPPCR------CMHGGNCYFDET-DLPKCKCPSGYTGKYCEMAFSKGISPGTTA- 4424
Query: 61 LFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSV 94
V L +L+ ++IGA + H++R S+
Sbjct: 4425 ---VAVLLTILLIVVIGAL-AIAGFFHYRRTGSL 4454
>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
sapiens]
Length = 1207
Score = 42.7 bits (99), Expect = 6e-05
Identities = 28/91 (30%), Positives = 41/91 (45%), Gaps = 13/91 (14%)
Query: 6 EEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCE-------EVFLPGSSIQTK 58
+ C SH +CL+ G+C I + C CV Y G RC+ E+ G Q K
Sbjct: 973 DSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELRHAGHGQQQK 1032
Query: 59 SNLFEAFVALAVLVTLII----GAFYFLCRK 85
+ V + VLV L++ GA Y+ +K
Sbjct: 1033 --VIVVAVCVVVLVMLLLLSLWGAHYYRTQK 1061
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 41.6 bits (96), Expect = 1e-04
Identities = 26/64 (40%), Positives = 33/64 (51%), Gaps = 7/64 (10%)
Query: 16 FCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSS----IQTKSNLFEAFVALAVL 71
+C NGG C + P P C C N++G +CE P SS I T+S V L +L
Sbjct: 4397 YCYNGGTCQLDPETNVPVCLCSTNWSGTQCERP-APKSSKSDHISTRS--IAIIVPLVLL 4453
Query: 72 VTLI 75
VTLI
Sbjct: 4454 VTLI 4457
Score = 37.0 bits (84), Expect = 0.003
Identities = 14/33 (42%), Positives = 19/33 (57%), Gaps = 1/33 (3%)
Query: 14 KSFCLNGGLCYVIPTIPSPFCRCVENYTGARCE 46
+ FC NGG C ++ P+C C YTG RC+
Sbjct: 4290 EDFCQNGGTC-IVTAGNQPYCHCQPEYTGDRCQ 4321
Score = 32.3 bits (72), Expect = 0.083
Identities = 17/45 (37%), Positives = 22/45 (48%), Gaps = 2/45 (4%)
Query: 2 PTDHEEPCGPSHKS-FCLNGGLCYVIPTIPSPFCRCVENYTGARC 45
P+ E C +H S +C NGG C V + P C C +TG C
Sbjct: 4241 PSYSGERCEVNHCSNYCQNGGTC-VPSVLGRPTCSCALGFTGPNC 4284
Score = 27.3 bits (59), Expect = 2.7
Identities = 14/35 (40%), Positives = 18/35 (51%), Gaps = 1/35 (2%)
Query: 12 SHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCE 46
S K C NGG C ++ C C +Y+G RCE
Sbjct: 4216 SCKLTCENGGRC-ILNEKGDLRCHCWPSYSGERCE 4249
>gi|153791414 transforming growth factor, alpha isoform 2 [Homo
sapiens]
Length = 159
Score = 41.2 bits (95), Expect = 2e-04
Identities = 24/79 (30%), Positives = 32/79 (40%), Gaps = 3/79 (3%)
Query: 5 HEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSNLFEA 64
H C SH FC +G C + P C C Y GARCE L ++ S +A
Sbjct: 42 HFNDCPDSHTQFCFHG-TCRFLVQEDKPACVCHSGYVGARCEHADL--LAVVAASQKKQA 98
Query: 65 FVALAVLVTLIIGAFYFLC 83
AL V+ + + C
Sbjct: 99 ITALVVVSIVALAVLIITC 117
>gi|4507461 transforming growth factor, alpha isoform 1 [Homo
sapiens]
Length = 160
Score = 41.2 bits (95), Expect = 2e-04
Identities = 24/79 (30%), Positives = 32/79 (40%), Gaps = 3/79 (3%)
Query: 5 HEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSNLFEA 64
H C SH FC +G C + P C C Y GARCE L ++ S +A
Sbjct: 43 HFNDCPDSHTQFCFHG-TCRFLVQEDKPACVCHSGYVGARCEHADL--LAVVAASQKKQA 99
Query: 65 FVALAVLVTLIIGAFYFLC 83
AL V+ + + C
Sbjct: 100 ITALVVVSIVALAVLIITC 118
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 38.9 bits (89), Expect = 9e-04
Identities = 16/31 (51%), Positives = 20/31 (64%), Gaps = 1/31 (3%)
Query: 17 CLNGGLCYVIPTIPSPF-CRCVENYTGARCE 46
CLNGG C V +P F CRC ++GARC+
Sbjct: 1313 CLNGGTCAVASNMPDGFICRCPPGFSGARCQ 1343
Score = 37.0 bits (84), Expect = 0.003
Identities = 15/42 (35%), Positives = 20/42 (47%), Gaps = 3/42 (7%)
Query: 5 HEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCE 46
H +PC K+ C NGG C + CRC +TG C+
Sbjct: 64 HRDPC---EKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQ 102
Score = 33.5 bits (75), Expect = 0.037
Identities = 18/53 (33%), Positives = 25/53 (47%), Gaps = 3/53 (5%)
Query: 2 PTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSS 54
P D E C S C +GG C+ P C+C ++G+RCE P S+
Sbjct: 1371 PRDCESGCASSP---CQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPST 1420
Score = 32.7 bits (73), Expect = 0.063
Identities = 17/49 (34%), Positives = 26/49 (53%), Gaps = 5/49 (10%)
Query: 3 TDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLP 51
TD E P H C +GG C +P S C+C + +TG C+ +++P
Sbjct: 181 TDVNECDIPGH---CQHGGTCLNLPG--SYQCQCPQGFTGQYCDSLYVP 224
Score = 32.7 bits (73), Expect = 0.063
Identities = 19/59 (32%), Positives = 27/59 (45%), Gaps = 9/59 (15%)
Query: 17 CLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLP-------GSSIQTKSNLFEAFVAL 68
CLN G C+ I C CV YTG C+ V P +++ +S FE++ L
Sbjct: 804 CLNQGTCF--DDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCL 860
Score = 32.0 bits (71), Expect = 0.11
Identities = 14/30 (46%), Positives = 17/30 (56%), Gaps = 2/30 (6%)
Query: 17 CLNGGLCYVIPTIPSPFCRCVENYTGARCE 46
CLNGG C + I CRC+ + G RCE
Sbjct: 1235 CLNGGQC--MDRIGGYSCRCLPGFAGERCE 1262
Score = 30.0 bits (66), Expect = 0.41
Identities = 13/44 (29%), Positives = 23/44 (52%), Gaps = 2/44 (4%)
Query: 3 TDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCE 46
T+ + C ++ + C + G C + T + C C++ Y G RCE
Sbjct: 413 TEDVDECAMANSNPCEHAGKC--VNTDGAFHCECLKGYAGPRCE 454
Score = 29.6 bits (65), Expect = 0.54
Identities = 14/37 (37%), Positives = 21/37 (56%), Gaps = 4/37 (10%)
Query: 11 PSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEE 47
P+H+ C NGG+C + + + CRC +TG C E
Sbjct: 265 PNHR--CQNGGVC--VDGVNTYNCRCPPQWTGQFCTE 297
Score = 29.3 bits (64), Expect = 0.70
Identities = 15/41 (36%), Positives = 22/41 (53%), Gaps = 8/41 (19%)
Query: 17 CLNGGLCYVIPTIPSPF-CRCVENYTGARCE----EVFLPG 52
C NG C T+ + F C+C+ +TG +CE E +PG
Sbjct: 153 CANGSTC---TTVANQFSCKCLTGFTGQKCETDVNECDIPG 190
Score = 29.3 bits (64), Expect = 0.70
Identities = 13/38 (34%), Positives = 16/38 (42%), Gaps = 3/38 (7%)
Query: 8 PCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARC 45
PC P+ C N +C P S C C + G RC
Sbjct: 836 PCSPNP---CENAAVCKESPNFESYTCLCAPGWQGQRC 870
Score = 28.9 bits (63), Expect = 0.92
Identities = 14/39 (35%), Positives = 18/39 (46%), Gaps = 4/39 (10%)
Query: 8 PCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCE 46
PC PS C+NGG C C C+ + G+ CE
Sbjct: 224 PCAPSP---CVNGGTCRQTGDFTFE-CNCLPGFEGSTCE 258
Score = 28.9 bits (63), Expect = 0.92
Identities = 13/31 (41%), Positives = 17/31 (54%), Gaps = 2/31 (6%)
Query: 17 CLNGGLCYVIPTIPSPFCRCVENYTGARCEE 47
C+N GLC+ T S C C ++G CEE
Sbjct: 882 CMNHGLCH--NTQGSYMCECPPGFSGMDCEE 910
Score = 28.5 bits (62), Expect = 1.2
Identities = 14/39 (35%), Positives = 21/39 (53%), Gaps = 5/39 (12%)
Query: 12 SHKSF----CLNGGLCYVIPTIPSPFCRCVENYTGARCE 46
SH F CLNGG C+++ + + C C +TG C+
Sbjct: 106 SHPCFVSRPCLNGGTCHML-SRDTYECTCQVGFTGKECQ 143
Score = 28.5 bits (62), Expect = 1.2
Identities = 13/31 (41%), Positives = 15/31 (48%), Gaps = 2/31 (6%)
Query: 17 CLNGGLCYVIPTIPSPFCRCVENYTGARCEE 47
CLNG C P C+C +TG CEE
Sbjct: 541 CLNGAKCIDHPN--GYECQCATGFTGVLCEE 569
Score = 28.5 bits (62), Expect = 1.2
Identities = 12/35 (34%), Positives = 17/35 (48%), Gaps = 8/35 (22%)
Query: 13 HKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEE 47
H C+N G + +C+C YTG+ CEE
Sbjct: 1122 HSGVCINAGNTH--------YCQCPLGYTGSYCEE 1148
Score = 28.1 bits (61), Expect = 1.6
Identities = 12/31 (38%), Positives = 13/31 (41%)
Query: 17 CLNGGLCYVIPTIPSPFCRCVENYTGARCEE 47
C G LC P C C + Y GA C E
Sbjct: 384 CHKGALCDTNPLNGQYICTCPQGYKGADCTE 414
Score = 25.8 bits (55), Expect = 7.7
Identities = 13/43 (30%), Positives = 21/43 (48%), Gaps = 2/43 (4%)
Query: 4 DHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCE 46
D EE + C NGG C + + + C C+ +TG +C+
Sbjct: 907 DCEEDIDDCLANPCQNGGSC--MDGVNTFSCLCLPGFTGDKCQ 947
>gi|4502199 amphiregulin preproprotein [Homo sapiens]
Length = 252
Score = 38.9 bits (89), Expect = 9e-04
Identities = 20/71 (28%), Positives = 35/71 (49%), Gaps = 1/71 (1%)
Query: 6 EEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSNLFEAF 65
+ PC ++FC++G C I + + C+C + Y G RC E + S+ S A
Sbjct: 143 KNPCNAEFQNFCIHGE-CKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIAL 201
Query: 66 VALAVLVTLII 76
A+A ++ +I
Sbjct: 202 AAIAAFMSAVI 212
>gi|113415639 PREDICTED: amphiregulin B [Homo sapiens]
Length = 252
Score = 38.9 bits (89), Expect = 9e-04
Identities = 20/71 (28%), Positives = 35/71 (49%), Gaps = 1/71 (1%)
Query: 6 EEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSNLFEAF 65
+ PC ++FC++G C I + + C+C + Y G RC E + S+ S A
Sbjct: 143 KNPCNAEFQNFCIHGE-CKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIAL 201
Query: 66 VALAVLVTLII 76
A+A ++ +I
Sbjct: 202 AAIAAFMSAVI 212
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.136 0.436
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 4,692,292
Number of Sequences: 37866
Number of extensions: 187516
Number of successful extensions: 1084
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 72
Number of HSP's successfully gapped in prelim test: 80
Number of HSP's that attempted gapping in prelim test: 671
Number of HSP's gapped (non-prelim): 452
length of query: 115
length of database: 18,247,518
effective HSP length: 85
effective length of query: 30
effective length of database: 15,028,908
effective search space: 450867240
effective search space used: 450867240
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 55 (25.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.