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Search of human proteins with 19924129
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19924129 RAD50 homolog isoform 1 [Homo sapiens]
(1312 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19924129 RAD50 homolog isoform 1 [Homo sapiens] 2554 0.0
gi|19924131 RAD50 homolog isoform 2 [Homo sapiens] 2280 0.0
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 149 1e-35
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 149 1e-35
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 147 9e-35
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 147 9e-35
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 144 6e-34
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 144 7e-34
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 143 9e-34
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 143 1e-33
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 143 1e-33
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 138 3e-32
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 137 9e-32
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 136 1e-31
gi|71061468 centromere protein E [Homo sapiens] 136 2e-31
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 135 2e-31
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 135 2e-31
gi|21735548 centrosomal protein 2 [Homo sapiens] 134 4e-31
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 134 4e-31
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 134 7e-31
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 133 1e-30
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 132 2e-30
gi|58530840 desmoplakin isoform I [Homo sapiens] 131 5e-30
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 131 5e-30
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 130 6e-30
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 129 2e-29
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 129 2e-29
gi|28416946 myosin 18A isoform a [Homo sapiens] 129 2e-29
gi|156104908 myosin heavy chain 6 [Homo sapiens] 128 3e-29
gi|118498356 kinectin 1 isoform a [Homo sapiens] 127 5e-29
>gi|19924129 RAD50 homolog isoform 1 [Homo sapiens]
Length = 1312
Score = 2554 bits (6620), Expect = 0.0
Identities = 1312/1312 (100%), Positives = 1312/1312 (100%)
Query: 1 MSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPG 60
MSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPG
Sbjct: 1 MSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPG 60
Query: 61 TKGNTFVHDPKVAQETDVRAQIRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITR 120
TKGNTFVHDPKVAQETDVRAQIRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITR
Sbjct: 61 TKGNTFVHDPKVAQETDVRAQIRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITR 120
Query: 121 TKHGEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIF 180
TKHGEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIF
Sbjct: 121 TKHGEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIF 180
Query: 181 SATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEI 240
SATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEI
Sbjct: 181 SATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEI 240
Query: 241 VKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGT 300
VKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGT
Sbjct: 241 VKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGT 300
Query: 301 DEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRH 360
DEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRH
Sbjct: 301 DEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRH 360
Query: 361 QEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAE 420
QEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAE
Sbjct: 361 QEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAE 420
Query: 421 KETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQE 480
KETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQE
Sbjct: 421 KETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQE 480
Query: 481 LIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEM 540
LIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEM
Sbjct: 481 LIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEM 540
Query: 541 LTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKE 600
LTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKE
Sbjct: 541 LTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKE 600
Query: 601 LASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLA 660
LASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLA
Sbjct: 601 LASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLA 660
Query: 661 GATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELK 720
GATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELK
Sbjct: 661 GATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELK 720
Query: 721 KKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMP 780
KKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMP
Sbjct: 721 KKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMP 780
Query: 781 EEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLD 840
EEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLD
Sbjct: 781 EEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLD 840
Query: 841 TVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQS 900
TVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQS
Sbjct: 841 TVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQS 900
Query: 901 LYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKD 960
LYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKD
Sbjct: 901 LYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKD 960
Query: 961 IENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQD 1020
IENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQD
Sbjct: 961 IENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQD 1020
Query: 1021 NLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKG 1080
NLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKG
Sbjct: 1021 NLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKG 1080
Query: 1081 YEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKM 1140
YEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKM
Sbjct: 1081 YEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKM 1140
Query: 1141 EEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGR 1200
EEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGR
Sbjct: 1141 EEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGR 1200
Query: 1201 CSAGQKVLASLIIRLALAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQR 1260
CSAGQKVLASLIIRLALAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQR
Sbjct: 1201 CSAGQKVLASLIIRLALAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQR 1260
Query: 1261 NFQLLVITHDEDFVELLGRSEYVEKFYRIKKNIDQCSEIVKCSVSSLGFNVH 1312
NFQLLVITHDEDFVELLGRSEYVEKFYRIKKNIDQCSEIVKCSVSSLGFNVH
Sbjct: 1261 NFQLLVITHDEDFVELLGRSEYVEKFYRIKKNIDQCSEIVKCSVSSLGFNVH 1312
>gi|19924131 RAD50 homolog isoform 2 [Homo sapiens]
Length = 1173
Score = 2280 bits (5908), Expect = 0.0
Identities = 1173/1173 (100%), Positives = 1173/1173 (100%)
Query: 140 MISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQ 199
MISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQ
Sbjct: 1 MISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQ 60
Query: 200 GQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIE 259
GQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIE
Sbjct: 61 GQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIE 120
Query: 260 HNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKE 319
HNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKE
Sbjct: 121 HNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKE 180
Query: 320 RKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLE 379
RKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLE
Sbjct: 181 RKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLE 240
Query: 380 LDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGL 439
LDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGL
Sbjct: 241 LDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGL 300
Query: 440 GRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVET 499
GRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVET
Sbjct: 301 GRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVET 360
Query: 500 LKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRH 559
LKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRH
Sbjct: 361 LKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRH 420
Query: 560 SDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKE 619
SDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKE
Sbjct: 421 SDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKE 480
Query: 620 EQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQS 679
EQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQS
Sbjct: 481 EQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQS 540
Query: 680 CCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSI 739
CCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSI
Sbjct: 541 CCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSI 600
Query: 740 IDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQ 799
IDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQ
Sbjct: 601 IDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQ 660
Query: 800 MELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQ 859
MELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQ
Sbjct: 661 MELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQ 720
Query: 860 IQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTL 919
IQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTL
Sbjct: 721 IQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTL 780
Query: 920 EKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETE 979
EKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETE
Sbjct: 781 EKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETE 840
Query: 980 LNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERK 1039
LNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERK
Sbjct: 841 LNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERK 900
Query: 1040 QHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRD 1099
QHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRD
Sbjct: 901 QHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRD 960
Query: 1100 AEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQD 1159
AEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQD
Sbjct: 961 AEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQD 1020
Query: 1160 IEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLALAE 1219
IEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLALAE
Sbjct: 1021 IEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLALAE 1080
Query: 1220 TFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGR 1279
TFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGR
Sbjct: 1081 TFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGR 1140
Query: 1280 SEYVEKFYRIKKNIDQCSEIVKCSVSSLGFNVH 1312
SEYVEKFYRIKKNIDQCSEIVKCSVSSLGFNVH
Sbjct: 1141 SEYVEKFYRIKKNIDQCSEIVKCSVSSLGFNVH 1173
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 149 bits (377), Expect = 1e-35
Identities = 187/882 (21%), Positives = 389/882 (44%), Gaps = 119/882 (13%)
Query: 187 KALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYEN 246
K E L+ ++ + LK +++ + ++++ + S+ A +++ +
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153
Query: 247 ELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLND 306
EL+ LK L++ LD+ + R K+ E++ + L++ +++ + + Q+ +
Sbjct: 1154 ELEALKTELEDT---------LDSTATQQELRAKR-EQEVTVLKKALDEETRSHEAQVQE 1203
Query: 307 LYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRA 366
+ H + V E +L R L+K + L +E ++L E R+ QA + EH +
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL-RVLGQAKQEVEHKKK 1262
Query: 367 R-DSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLK 425
+ ++ +Q L ++ R +++ HKL + E ++ ++N+ K
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDK----VHKL-----QNEVESVTGMLNEAEGKAIKL 1313
Query: 426 QKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAE 485
K + + + ++ E+L ++ + NV +L+QLE + + + E ++A+
Sbjct: 1314 AKDVASLSSQ-------LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1366
Query: 486 RELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDK 545
+ L + ++ TL +++ + + D T+ L++ ++ TQ ++K
Sbjct: 1367 QNLER-----HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY---EEK 1418
Query: 546 ADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQT--------------R 591
A +++ K K+R EL L+ N++QL L K ++ +Q R
Sbjct: 1419 AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1478
Query: 592 DRLAKLNKE-------LASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDR 644
DR +E LA + + EL+R + L + ++ D+ S+D D+ +
Sbjct: 1479 DRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKA---EMEDLVSSKD---DVGK 1532
Query: 645 LKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVF--------QTEAELQE 696
E+EKS +RA+ + +Q + +L DE Q+ R+ Q E +LQ
Sbjct: 1533 NVHELEKS--KRALETQMEEMKTQ-LEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1589
Query: 697 VISDLQSKLRLAPDKLKSTESELKKKEKRR-----------DEMLGLVPMRQSIIDLKEK 745
+ K R +L E+EL+ + K+R ++ L S I +E+
Sbjct: 1590 RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1649
Query: 746 EIPELRNKLQNVNRDIQRLKNDIE-EQETLLGTIMPEEESAKVCLTDVTIM-------ER 797
I +LR KLQ +D QR D ++ + T E+ AK D+ + ER
Sbjct: 1650 AIKQLR-KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1708
Query: 798 FQMELKDVERKIAQQ-AAKLQGID--------LDRTVQQVNQEKQEKQHKLDTVSSKIEL 848
+ + + ++A++ A+ L G + L+ + Q+ +E +E+Q ++ +S ++
Sbjct: 1709 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV-- 1766
Query: 849 NRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDA 908
RK Q Q EQ+ +NEL +E+ N RQQLE Q EL +++ + +K
Sbjct: 1767 -RKATQ-QAEQL------SNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK 1818
Query: 909 -KEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQD 967
K ++ LE + + +++ E+ +K + K + K +KE + + K E Y +
Sbjct: 1819 FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ 1878
Query: 968 GKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDID 1009
+ + K+ + QL E E+ ++IN + R +++++D
Sbjct: 1879 AEKGNARVKQLK-----RQLEEAEEESQRINANRRKLQRELD 1915
Score = 143 bits (360), Expect = 1e-33
Identities = 212/1057 (20%), Positives = 459/1057 (43%), Gaps = 163/1057 (15%)
Query: 185 YIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSY 244
+ K L+ RQ + + KE EL+ K+ ++KA ++ K +QLT K +++
Sbjct: 845 FTKVKPLLQVTRQEEEMQAKED--ELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 245 ---ENE-----------LDPLKNRLKEIEHNL-SKIMKLDNEIKALDSRKKQMEKDNSEL 289
E E L K L+EI H + +++ + ++ + L + +K+M + +L
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 290 EEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVE 349
EE++E+ + ++L + +++ E +++ + KL+KE +LL + S+L
Sbjct: 963 EEQLEEE-EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021
Query: 350 QGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAK 409
+ +A + +S+I L +L+ + E+ + KL R + EG+A
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKE--------EKSRQELEKLKR-KLEGDA- 1071
Query: 410 TANQLMNDFAEKETLKQKQIDEIR----DKKTGLGRIIELKSEILSKKQNELKNVKYELQ 465
+DF E+ Q QI E++ K+ L + + +++K N LK ++
Sbjct: 1072 ------SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR---- 1121
Query: 466 QLEGS-SDRILELDQE-LIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQ 523
+LEG SD +LD E + + E K + +E LK E+ + A K +Q
Sbjct: 1122 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ 1181
Query: 524 EMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSK 583
E+ L + L ++ + Q+++++ +H+ + L +QLE + +K
Sbjct: 1182 EVTVLK---------KALDEETRSHEAQVQEMRQKHAQAVEEL------TEQLEQFKRAK 1226
Query: 584 SKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLD 643
+ +++ + L K N +LA + E++ K+++L + +L C SD +
Sbjct: 1227 A-NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC------SDGE 1279
Query: 644 RLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQS 703
R + E+ + +L +E +S + +L + ++ L S
Sbjct: 1280 RARAELNDK-----------------VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322
Query: 704 KLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQR 763
+L+ D + + E ++K ++ L R S+ D ++E+ +N ++++ +
Sbjct: 1323 QLQ---DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 764 LKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDR 823
L + ++ + T+ EE K RFQ E++++ ++ ++AA
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKK----------RFQKEIENLTQQYEEKAA--------- 1420
Query: 824 TVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTN-LQ 882
++ + K Q +LD + ++ R+L+ + +++ + ++L +E+ IS+
Sbjct: 1421 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK----QRKFDQLLAEEKNISSKYAD 1476
Query: 883 RRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQD 942
R + E + E T+ SL R +++A E LE T + + E E+L++ K+
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD-------- 1528
Query: 943 KLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMR 1002
+ KN+H K K+ ET++ ++ QL E E + ED +
Sbjct: 1529 ------DVGKNVHELEKS------------KRALETQMEEMKTQLEELEDELQ-ATEDAK 1569
Query: 1003 LMRQDIDTQKIQERWLQDNLTLRKRNEELK------------EVEEERKQHLKEMGQMQV 1050
L R +++ Q ++ ++ +D ++NEE + E+E+ERKQ + +
Sbjct: 1570 L-RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ--RALAAAAK 1626
Query: 1051 LQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKEL------REPQFRDAEEKY 1104
+++ + + LE D+ + A+ + + + ++ F++EL R+ F A+E
Sbjct: 1627 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1686
Query: 1105 REMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKII-RDLWRSTYRGQDIEYI 1163
++ + + +DL + QA ++ + E + + R+ + R +
Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746
Query: 1164 EIRSDADE---NVSA-SDKRRNYNYRVVMLKGDTALD 1196
++ + +E N+ A SD+ R + L + A +
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1783
Score = 51.2 bits (121), Expect = 6e-06
Identities = 64/361 (17%), Positives = 151/361 (41%), Gaps = 28/361 (7%)
Query: 856 QQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPL 915
Q+E++Q + + K + + L+ +Q Q E +Q + + + +
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916
Query: 916 ETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQ 975
L +QE EE++++ + +D+ ++ + K + M D+E +++ ++ +Q
Sbjct: 917 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQ 974
Query: 976 KETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVE 1035
K +L KV A+ + E + D + + + + ++ER L + E+ K +
Sbjct: 975 K-LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 1036 EERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREP 1095
+ + +H + +++V K E K + ++ +KR G + E+I + ++ E
Sbjct: 1034 KLKNKHESMISELEVRLKKEE--KSRQELEKLKRKLE---GDASDFHEQIADLQAQIAEL 1088
Query: 1096 QFRDAEEKYREMMIVMRTTELVN---------KDLDIYYKTLDQAIMKFHSMKMEEINKI 1146
+ + A+++ + R + + ++L+ + L + + + + + K
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR-NKAEKQ 1147
Query: 1147 IRDLWRSTYRGQDIEYI--EIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAG 1204
RDL G+++E + E+ D + + R V +LK ALD R
Sbjct: 1148 KRDL------GEELEALKTELEDTLDSTATQQELRAKREQEVTVLK--KALDEETRSHEA 1199
Query: 1205 Q 1205
Q
Sbjct: 1200 Q 1200
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 149 bits (377), Expect = 1e-35
Identities = 187/882 (21%), Positives = 389/882 (44%), Gaps = 119/882 (13%)
Query: 187 KALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYEN 246
K E L+ ++ + LK +++ + ++++ + S+ A +++ +
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146
Query: 247 ELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLND 306
EL+ LK L++ LD+ + R K+ E++ + L++ +++ + + Q+ +
Sbjct: 1147 ELEALKTELEDT---------LDSTATQQELRAKR-EQEVTVLKKALDEETRSHEAQVQE 1196
Query: 307 LYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRA 366
+ H + V E +L R L+K + L +E ++L E R+ QA + EH +
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL-RVLGQAKQEVEHKKK 1255
Query: 367 R-DSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLK 425
+ ++ +Q L ++ R +++ HKL + E ++ ++N+ K
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDK----VHKL-----QNEVESVTGMLNEAEGKAIKL 1306
Query: 426 QKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAE 485
K + + + ++ E+L ++ + NV +L+QLE + + + E ++A+
Sbjct: 1307 AKDVASLSSQ-------LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1359
Query: 486 RELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDK 545
+ L + ++ TL +++ + + D T+ L++ ++ TQ ++K
Sbjct: 1360 QNLER-----HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY---EEK 1411
Query: 546 ADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQT--------------R 591
A +++ K K+R EL L+ N++QL L K ++ +Q R
Sbjct: 1412 AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1471
Query: 592 DRLAKLNKE-------LASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDR 644
DR +E LA + + EL+R + L + ++ D+ S+D D+ +
Sbjct: 1472 DRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKA---EMEDLVSSKD---DVGK 1525
Query: 645 LKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVF--------QTEAELQE 696
E+EKS +RA+ + +Q + +L DE Q+ R+ Q E +LQ
Sbjct: 1526 NVHELEKS--KRALETQMEEMKTQ-LEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1582
Query: 697 VISDLQSKLRLAPDKLKSTESELKKKEKRR-----------DEMLGLVPMRQSIIDLKEK 745
+ K R +L E+EL+ + K+R ++ L S I +E+
Sbjct: 1583 RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1642
Query: 746 EIPELRNKLQNVNRDIQRLKNDIE-EQETLLGTIMPEEESAKVCLTDVTIM-------ER 797
I +LR KLQ +D QR D ++ + T E+ AK D+ + ER
Sbjct: 1643 AIKQLR-KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1701
Query: 798 FQMELKDVERKIAQQ-AAKLQGID--------LDRTVQQVNQEKQEKQHKLDTVSSKIEL 848
+ + + ++A++ A+ L G + L+ + Q+ +E +E+Q ++ +S ++
Sbjct: 1702 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV-- 1759
Query: 849 NRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDA 908
RK Q Q EQ+ +NEL +E+ N RQQLE Q EL +++ + +K
Sbjct: 1760 -RKATQ-QAEQL------SNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK 1811
Query: 909 -KEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQD 967
K ++ LE + + +++ E+ +K + K + K +KE + + K E Y +
Sbjct: 1812 FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ 1871
Query: 968 GKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDID 1009
+ + K+ + QL E E+ ++IN + R +++++D
Sbjct: 1872 AEKGNARVKQLK-----RQLEEAEEESQRINANRRKLQRELD 1908
Score = 143 bits (360), Expect = 1e-33
Identities = 212/1057 (20%), Positives = 459/1057 (43%), Gaps = 163/1057 (15%)
Query: 185 YIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSY 244
+ K L+ RQ + + KE EL+ K+ ++KA ++ K +QLT K +++
Sbjct: 838 FTKVKPLLQVTRQEEEMQAKED--ELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895
Query: 245 ---ENE-----------LDPLKNRLKEIEHNL-SKIMKLDNEIKALDSRKKQMEKDNSEL 289
E E L K L+EI H + +++ + ++ + L + +K+M + +L
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 290 EEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVE 349
EE++E+ + ++L + +++ E +++ + KL+KE +LL + S+L
Sbjct: 956 EEQLEEE-EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014
Query: 350 QGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAK 409
+ +A + +S+I L +L+ + E+ + KL R + EG+A
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKE--------EKSRQELEKLKR-KLEGDA- 1064
Query: 410 TANQLMNDFAEKETLKQKQIDEIR----DKKTGLGRIIELKSEILSKKQNELKNVKYELQ 465
+DF E+ Q QI E++ K+ L + + +++K N LK ++
Sbjct: 1065 ------SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR---- 1114
Query: 466 QLEGS-SDRILELDQE-LIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQ 523
+LEG SD +LD E + + E K + +E LK E+ + A K +Q
Sbjct: 1115 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ 1174
Query: 524 EMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSK 583
E+ L + L ++ + Q+++++ +H+ + L +QLE + +K
Sbjct: 1175 EVTVLK---------KALDEETRSHEAQVQEMRQKHAQAVEEL------TEQLEQFKRAK 1219
Query: 584 SKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLD 643
+ +++ + L K N +LA + E++ K+++L + +L C SD +
Sbjct: 1220 A-NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC------SDGE 1272
Query: 644 RLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQS 703
R + E+ + +L +E +S + +L + ++ L S
Sbjct: 1273 RARAELNDK-----------------VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315
Query: 704 KLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQR 763
+L+ D + + E ++K ++ L R S+ D ++E+ +N ++++ +
Sbjct: 1316 QLQ---DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 764 LKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDR 823
L + ++ + T+ EE K RFQ E++++ ++ ++AA
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKK----------RFQKEIENLTQQYEEKAA--------- 1413
Query: 824 TVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTN-LQ 882
++ + K Q +LD + ++ R+L+ + +++ + ++L +E+ IS+
Sbjct: 1414 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK----QRKFDQLLAEEKNISSKYAD 1469
Query: 883 RRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQD 942
R + E + E T+ SL R +++A E LE T + + E E+L++ K+
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD-------- 1521
Query: 943 KLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMR 1002
+ KN+H K K+ ET++ ++ QL E E + ED +
Sbjct: 1522 ------DVGKNVHELEKS------------KRALETQMEEMKTQLEELEDELQ-ATEDAK 1562
Query: 1003 LMRQDIDTQKIQERWLQDNLTLRKRNEELK------------EVEEERKQHLKEMGQMQV 1050
L R +++ Q ++ ++ +D ++NEE + E+E+ERKQ + +
Sbjct: 1563 L-RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ--RALAAAAK 1619
Query: 1051 LQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKEL------REPQFRDAEEKY 1104
+++ + + LE D+ + A+ + + + ++ F++EL R+ F A+E
Sbjct: 1620 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1679
Query: 1105 REMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKII-RDLWRSTYRGQDIEYI 1163
++ + + +DL + QA ++ + E + + R+ + R +
Sbjct: 1680 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739
Query: 1164 EIRSDADE---NVSA-SDKRRNYNYRVVMLKGDTALD 1196
++ + +E N+ A SD+ R + L + A +
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1776
Score = 51.2 bits (121), Expect = 6e-06
Identities = 64/361 (17%), Positives = 151/361 (41%), Gaps = 28/361 (7%)
Query: 856 QQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPL 915
Q+E++Q + + K + + L+ +Q Q E +Q + + + +
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909
Query: 916 ETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQ 975
L +QE EE++++ + +D+ ++ + K + M D+E +++ ++ +Q
Sbjct: 910 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQ 967
Query: 976 KETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVE 1035
K +L KV A+ + E + D + + + + ++ER L + E+ K +
Sbjct: 968 K-LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 1036 EERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREP 1095
+ + +H + +++V K E K + ++ +KR G + E+I + ++ E
Sbjct: 1027 KLKNKHESMISELEVRLKKEE--KSRQELEKLKRKLE---GDASDFHEQIADLQAQIAEL 1081
Query: 1096 QFRDAEEKYREMMIVMRTTELVN---------KDLDIYYKTLDQAIMKFHSMKMEEINKI 1146
+ + A+++ + R + + ++L+ + L + + + + + K
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR-NKAEKQ 1140
Query: 1147 IRDLWRSTYRGQDIEYI--EIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAG 1204
RDL G+++E + E+ D + + R V +LK ALD R
Sbjct: 1141 KRDL------GEELEALKTELEDTLDSTATQQELRAKREQEVTVLK--KALDEETRSHEA 1192
Query: 1205 Q 1205
Q
Sbjct: 1193 Q 1193
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 147 bits (370), Expect = 9e-35
Identities = 207/1000 (20%), Positives = 435/1000 (43%), Gaps = 135/1000 (13%)
Query: 187 KALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYEN 246
K + ++Q Q V E Q +L+ K+ E +++ + +L S +E+V EN
Sbjct: 500 KISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELEN 559
Query: 247 ELDPLKNR--------------LKEIEHNLSK--------IMKLDNEIKALDSRKKQMEK 284
+ L+ + LKE+E ++ I KL N + +D+ K+ E+
Sbjct: 560 TIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCER 619
Query: 285 DNS---ELEEKMEKVFQGTDE---QLNDLYHNHQRTVREKER---KLVDCHRELEKLNKE 335
+ EL +K+E+ Q E ++N+L + T++EK++ KL +++ L+++
Sbjct: 620 EERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSED 679
Query: 336 SRLLNQEKSELLVEQGRL-----QLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSE 390
+L+ E L E +L QL D + D +++ TQLE ++
Sbjct: 680 KEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLE----KKLQLMV 735
Query: 391 RQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEIL 450
+ N +KL+ Q + QL E + ++ E ++K + +++ E L
Sbjct: 736 EEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGS----EVSEDSEEKDVVN-VLQAVGESL 790
Query: 451 SKKQNELKNVKYELQQLEGSSDRILELDQEL--IKAERELSKAEKNSNVETLKMEVISLQ 508
+K E N+ ++ +++LEL++E+ ++ E + E S + + E + L+
Sbjct: 791 AKINEEKCNLAFQ------RDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLR 844
Query: 509 NEKADLDRTLRKLDQEM-EQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLL 567
E ++ L ++ E N + TR + + L + + K + + E +
Sbjct: 845 KELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIK 904
Query: 568 GYFPNKKQLEDW-LHSKSKEINQTRDRLAKL----NKELASSEQNKNHINN---ELKRKE 619
+ K LE L + E+ +D LAK N L+S ++ + I N E K KE
Sbjct: 905 EHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKE 964
Query: 620 EQLSSYEDKLFDVCGSQDFES---DLDRLKEEIEK--------SSKQRAMLAGATAVYSQ 668
E+++ KL V ++ +S + +KEE+E S+ R ++ GA + Y
Sbjct: 965 EKINKI--KLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAES-YKN 1021
Query: 669 FITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDE 728
+ + +++ +R E ++ DL +LR + + ++ S+ ++
Sbjct: 1022 LLLEYEKQSEQLDVEKERANNFEHRIE----DLTRQLRNSTLQCETINSD-------NED 1070
Query: 729 MLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVC 788
+L + QS L E +I E++ V+++++ K E++ T + E E +V
Sbjct: 1071 LLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQ 1130
Query: 789 LTDVTIMERFQMELKDVERKIAQQAA--KLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKI 846
L + M+ ++ +K AQQ ++ D +R ++++NQ+ K +K++ + +I
Sbjct: 1131 LQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEI 1190
Query: 847 ELNRKLIQDQQEQIQHLKSTTNE-----LKSEKLQISTNLQRRQQLEEQTVELSTEVQSL 901
++ ++ + QE+I L+S+ + K ++L + T + + +T L + SL
Sbjct: 1191 KIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQA-SL 1249
Query: 902 YREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKV---------- 951
E++ +++QV + L + EK ++ TS + Q L+ +++V
Sbjct: 1250 KGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAA 1309
Query: 952 --------KNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRL 1003
Y + N ++ K+ Q ETE K + +H E + + +++
Sbjct: 1310 KAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAK------QEREHLEMLIDQLKI 1363
Query: 1004 MRQD------IDTQKIQERWLQDNLTLRKRNEELKEV---EEERKQHLKEMGQMQVLQMK 1054
QD I+ ++Q + + L + N+ L+E E E ++ L + Q + + MK
Sbjct: 1364 KLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSI-QSENMMMK 1422
Query: 1055 SEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELRE 1094
SEH + + + +N L + + +++ H ++E R+
Sbjct: 1423 SEHTQTVSQLTS--QNEVL----RNSFRDQVRHLQEEHRK 1456
Score = 120 bits (302), Expect = 7e-27
Identities = 237/1178 (20%), Positives = 491/1178 (41%), Gaps = 196/1178 (16%)
Query: 234 LTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMK-LDNEIKALDSRKKQMEKDNSELEEK 292
+ +K E E++ L++ K + I+K L + AL K + E+ L+++
Sbjct: 41 IQKAKSRCTELEKEIEELRS--KPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKE 98
Query: 293 MEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGR 352
K+ Q ++ + + H +E E+ ++ +E+E L E + + SE ++
Sbjct: 99 NIKMKQEVEDSVTKMGDAH----KELEQSHINYVKEIENLKNELMAVRSKYSE---DKAN 151
Query: 353 LQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTAN 412
LQ Q + +++ TQLEL E+ F N KL E ++
Sbjct: 152 LQKQLE-------------EAMNTQLELS--EQLKFQNNSEDNVKKLQEEIEK------- 189
Query: 413 QLMNDFAEKETLKQKQIDEIRDKK----TGLGRIIELKSEILSKKQNELKNVKYELQQLE 468
+ F E+ QKQ+D D+K T L IIE S+ K N L+ +L+ +
Sbjct: 190 -IRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIH 248
Query: 469 GSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQL 528
+ L E E E + N E L + +A +K + E+E L
Sbjct: 249 QEEVKELMCQIEASAKEHEAEINKLNELKENLVKQC------EASEKNIQKKYECELENL 302
Query: 529 NHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEIN 588
T+ A++D QI I + + + ++ K LED L + +
Sbjct: 303 RKATSN-----------ANQDNQICSILLQENTFVEQVVN--EKVKHLEDTLKELESQHS 349
Query: 589 QTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEE 648
+D + +N E + HI +E + E L ++L + ++ +++LK E
Sbjct: 350 ILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINEL--LLAKEEQGCVIEKLKSE 407
Query: 649 IEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLA 708
+ +KQ +++ + L +++Q F +++E +++ L +++
Sbjct: 408 LAGLNKQ---FCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLT--LMFEIQGL 462
Query: 709 PDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQ------------N 756
++ ++ + E +++ +L +R+ I+++ + E+ E K+ +
Sbjct: 463 KEQCENLQQE------KQEAILNYESLRE-IMEILQTELGESAGKISQEFESMKQQQASD 515
Query: 757 VNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERK-------I 809
V+ Q+L+ E++ LL T+ + + L+ ++ + +K+++ K +
Sbjct: 516 VHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSL 575
Query: 810 AQQAAKLQGIDLDRTVQQVNQEKQEKQHKL-------DTVSSKIELNRKLIQDQQEQIQH 862
+Q+ L+ +L+ + + +EK + +KL D K E +LI + ++++
Sbjct: 576 SQRDTMLK--ELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQ 633
Query: 863 LKSTTNELKSEKLQISTNL--------QRRQQLEEQTVE----------LSTEVQSLYRE 904
+EL+ + +++ L Q Q+LE+ V+ LS EV+SLY E
Sbjct: 634 TIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEE 693
Query: 905 IKDAKEQVSPLETTLEKFQQEKEELINKKNTSN---KIA-----QDKLNDIKEKVK---- 952
+ L LE F +KE++I K++ + K+ QD LN + E +
Sbjct: 694 NNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKL 753
Query: 953 ----NIHGYMKDIENYIQDGKDDYKKQKETELNKV---IAQLSECEKHKEKINEDMRLMR 1005
++G++K++ + + + D +K L V +A+++E EK D +++
Sbjct: 754 FVKTQLYGFLKEMGSEVSE--DSEEKDVVNVLQAVGESLAKINE-EKCNLAFQRDEKVLE 810
Query: 1006 QDIDTQKIQER--------------WLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVL 1051
+ + + +QE + Q+ + LRK EE++ +E + L EM
Sbjct: 811 LEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANE- 869
Query: 1052 QMKSEHQKLEENIDNIKRN------HNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYR 1105
+ + E+Q L ++ + + HN ++K + +E + K L + + RD +
Sbjct: 870 KTRLENQNLLIQVEEVSQTCSKSEIHN---EKEKCFIKEHENLKPLLEQKELRDRRAELI 926
Query: 1106 EMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSM---KMEEINKII-------RDLWRSTY 1155
+ + + V D K L++ I K E+INKI ++L S
Sbjct: 927 LLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRK 986
Query: 1156 RGQDI--EYIEIRSDADENVSASDK---RRNYNYRVVML---KGDTALDM-RGRCSAGQK 1206
Q + E +RS+ D+ +SAS + + +Y+ ++L K LD+ + R + +
Sbjct: 987 ETQTVKEELESLRSEKDQ-LSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEH 1045
Query: 1207 VLASLIIRLALAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLV 1266
+ L +L + C T N D E++ A +E ++S ++ Q+L
Sbjct: 1046 RIEDLTRQLRNSTLQC----------ETINSDNEDLL----ARIETLQSNAKLLEVQILE 1091
Query: 1267 ITHDEDFVELLGRSEYVEKFYRIKKNIDQCSEIVKCSV 1304
+ + V+ +E ++K +IK++ +E+ + V
Sbjct: 1092 VQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQV 1129
Score = 115 bits (288), Expect = 3e-25
Identities = 195/1026 (19%), Positives = 427/1026 (41%), Gaps = 154/1026 (15%)
Query: 181 SATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQ--YKEKACEIRDQITSKEAQLT--- 235
+ T+ +E Q Q ++E ++LK + Q KE C+I EA++
Sbjct: 215 TVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLN 274
Query: 236 ------------SSKEIVKSYENELDPLKNRLKEI--EHNLSKIMKLDN---------EI 272
S K I K YE EL+ L+ ++ + I+ +N ++
Sbjct: 275 ELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKV 334
Query: 273 KALDSRKKQMEKDNSELEEKMEKV------FQGTDEQLNDLYHNHQRTVREKERKLVDCH 326
K L+ K++E +S L++++ + + + + D + + + + K +L+
Sbjct: 335 KHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAK 394
Query: 327 RE----LEKLNKESRLLNQEKSELLVEQGR-LQLQADRHQEHIRA------RDSLIQSLA 375
E +EKL E LN++ + + R +Q ++HQ+ I DS + L
Sbjct: 395 EEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLT 454
Query: 376 TQLELDGFERGPFSERQIK--------NFHKLVRERQEGEAKTANQLMNDFAEKETLKQK 427
E+ G + + +Q K + +++ Q ++A ++ +F E++KQ+
Sbjct: 455 LMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEF---ESMKQQ 511
Query: 428 QIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERE 487
Q ++ + + L K +L + ++ E ++L + + EL+ + + +
Sbjct: 512 QASDVHELQQKLRTAFTEKDALLET----VNRLQGENEKLLSQQELVPELENTIKNLQEK 567
Query: 488 -----LSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLT 542
LS +++++ ++ L+ ++ SL EK D L+ +EM+ N H + E L
Sbjct: 568 NGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMD--NFHKKCERE-ERLI 624
Query: 543 KDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAK----LN 598
+ K EQ + S ++ L G + +D K +++ L++ L+
Sbjct: 625 LELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLS 684
Query: 599 KELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQ---DFESDLDRLKEEIEKSSK- 654
E+ S + N +++E K+ L + + DV + E L + EE + +K
Sbjct: 685 AEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKL 744
Query: 655 ----QRAMLAGATAVYSQFITQL------TDENQSCCPVCQRVFQTEAELQEVISDLQSK 704
Q L T +Y F+ ++ E + V Q V ++ A++ E +L +
Sbjct: 745 LENEQVQKLFVKTQLYG-FLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQ 803
Query: 705 LRLAPDKLKSTESELKKKEKRR----DEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRD 760
+K+ E E+K ++ +E+ L+ + L KE+ E++++ + + D
Sbjct: 804 ---RDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSD 860
Query: 761 IQRLKNDIE----EQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVE--------RK 808
+ +KN E E + LL + EE ++ C E+ + +K+ E ++
Sbjct: 861 LLEMKNANEKTRLENQNLLIQV---EEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKE 917
Query: 809 IAQQAAKLQGI-------------------DLDRTVQQVNQEKQEKQHKLDTVSSKIELN 849
+ + A+L + +L+ ++ + +E +EK+ K++ +
Sbjct: 918 LRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKA 977
Query: 850 RKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAK 909
+K + +++ Q +K L+SEK Q+S +++ Q E L E + ++ K
Sbjct: 978 KKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEK 1037
Query: 910 EQVSPLETTLEKFQQEKEELINKKNTSNKIAQD---KLNDIKEKVKNIHGYMKDIEN--- 963
E+ + E +E ++ + T N +D ++ ++ K + + +++
Sbjct: 1038 ERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKA 1097
Query: 964 YIQDGKDDYKKQKE----------TELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKI 1013
+ + K QKE EL ++ QL + +K +K +++ L+++D +
Sbjct: 1098 MVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTL 1157
Query: 1014 QERWLQD--------NLTLRKRNEELKEVEEERK--QHLKEMGQMQVLQMKSEHQKLEEN 1063
+ D N L +N +++++E+E K + +E Q ++ ++S Q+ EE
Sbjct: 1158 MNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEK 1217
Query: 1064 IDNIKR 1069
IK+
Sbjct: 1218 NTKIKQ 1223
Score = 95.1 bits (235), Expect = 4e-19
Identities = 170/872 (19%), Positives = 360/872 (41%), Gaps = 119/872 (13%)
Query: 151 LNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMEL 210
L I C QE+S E K+L + +++ R +++ + Q +K + Q +L
Sbjct: 811 LEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLR--------KELEEIQSEK-EALQSDL 861
Query: 211 KYLKQYKEKAC-----------EIRDQITSKEAQLTSSKEIVKSYEN-----ELDPLKNR 254
+K EK E+ + E K +K +EN E L++R
Sbjct: 862 LEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDR 921
Query: 255 LKEI---EHNLSKIMKLDNE----IKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDL 307
E+ + +L+K + N+ +K L+ + + +EK+ E EEK+ K+ + +L
Sbjct: 922 RAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKEL 981
Query: 308 YHNHQRTVREKERKLVDCHRELEKLNKESRLLNQ---EKSELLVEQGRLQLQADRHQEHI 364
+ + T KE +L E ++L+ R L Q LL+E + Q D +E
Sbjct: 982 DSSRKETQTVKE-ELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERA 1040
Query: 365 RARDSLIQSLATQLE--------LDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMN 416
+ I+ L QL ++ + + + + E Q E + A +++
Sbjct: 1041 NNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVD 1100
Query: 417 DFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILE 476
E E L+++Q +I++ T + + EL+ + L K++ +L+ EL+ ++ + +
Sbjct: 1101 KELEAEKLQKEQ--KIKEHATTVNELEELQVQ-LQKEKKQLQKTMQELELVKKDAQQTTL 1157
Query: 477 LDQELIKAERELSK-----AEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHH 531
++ E+ ER + + KN+ +E L+ E+ + ++ L + L ++Q
Sbjct: 1158 MNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEK 1217
Query: 532 TT------TRTQMEMLTKDKADKDEQIRKIKSRHSDELTS---------LLGYFPNKKQL 576
T +T+ E+ +A+ D I + + E + L K ++
Sbjct: 1218 NTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKI 1277
Query: 577 EDWLHSKSKEINQT----RDRLAKLNKELASS-----------EQNKNHINNELKRKEEQ 621
+ L + +++ +T + R+ L +E ++ E K ++N LK+++ +
Sbjct: 1278 HEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNK 1337
Query: 622 LSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAM-LAGATAVYSQFITQLTDENQSC 680
S + + E +D+LK +++ S + ++ + S+ T L N+
Sbjct: 1338 SMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNK-- 1395
Query: 681 CPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESEL-KKKEKRRDEMLGLVPMRQSI 739
+ Q EAEL+E + +QS+ + + T S+L + E R+ R +
Sbjct: 1396 --MLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSF------RDQV 1447
Query: 740 IDLKE---KEIPELRNKLQNVNRDIQRLKND------IEEQETLLGTIMPEEESAKVCLT 790
L+E K + L+ +L + + +LKN+ + Q++L + E + + L
Sbjct: 1448 RHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKN--LRERRNTDLPLL 1505
Query: 791 DVTIMERFQ---MELKDVERKIAQQAAKLQGID---------LDRTVQQVNQEKQEKQHK 838
D+ + R + ME D E ++ + Q ++ L+ + K+E K
Sbjct: 1506 DMHTVTREEGEGMETTDTE-SVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQK 1564
Query: 839 LDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEV 898
L + + + L+++ + L LKSE ++ N +R + + +
Sbjct: 1565 LSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLL 1624
Query: 899 QSLYREIKDAKEQVSP-LETTLEKFQQEKEEL 929
Q ++ + +E++ P + T L+ +EK +L
Sbjct: 1625 QFIFLKPGSERERLLPVINTMLQLSPEEKGKL 1656
Score = 51.6 bits (122), Expect = 5e-06
Identities = 81/384 (21%), Positives = 171/384 (44%), Gaps = 69/384 (17%)
Query: 779 MPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAK----------------LQGIDLD 822
+P+E+ K + ++++ + ++E++I + +K L + L+
Sbjct: 25 LPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLE 84
Query: 823 R--TVQQVNQEKQE----KQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNEL---KSE 873
+ T QQ K+E KQ D+V+ + +++L Q ++ +++ NEL +S+
Sbjct: 85 KAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSK 144
Query: 874 KLQISTNLQRRQQLEE---QTVELSTE----------VQSLYREIKDAK----EQVSPLE 916
+ NLQ+ QLEE +ELS + V+ L EI+ + EQ+ L+
Sbjct: 145 YSEDKANLQK--QLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQ 202
Query: 917 TTLEKFQQEKEELI----NKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDY 972
L+ EK+E + N +++ Q +N ++E++ + ++ + +
Sbjct: 203 KQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEAS 262
Query: 973 KKQKETELNKVIA----QLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDN---LTLR 1025
K+ E E+NK+ + +CE ++ I + +++ +K QDN L
Sbjct: 263 AKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENL--RKATSNANQDNQICSILL 320
Query: 1026 KRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEI 1085
+ N +++V E+ +HL++ + +++S+H L+ D + +NL L E +
Sbjct: 321 QENTFVEQVVNEKVKHLED----TLKELESQHSILK---DEVTYMNNLKL----KLEMDA 369
Query: 1086 IHFKKELREPQFRDAEEKYREMMI 1109
H K E + D E K E+++
Sbjct: 370 QHIKDEFFHER-EDLEFKINELLL 392
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 147 bits (370), Expect = 9e-35
Identities = 234/1083 (21%), Positives = 460/1083 (42%), Gaps = 194/1083 (17%)
Query: 109 TEFKTLEGVITRTKHGEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSE 168
T KTLE + R K E +L +C E I H+E SE
Sbjct: 276 TSVKTLETLQQRVKRQE--NLLKRCKE------------------TIQSHKEQCTLLTSE 315
Query: 169 GKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQIT 228
+AL+++ DE R + +K+K+ M K T
Sbjct: 316 KEALQEQLDE-----------------RLQELEKIKDLHMAEK----------------T 342
Query: 229 SKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSE 288
QL +K +++ E + + K H ++ + EI L SR KQM E
Sbjct: 343 KLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMK--EEEIAQLRSRIKQMTTQGEE 400
Query: 289 LEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLV----DCHRELEKLNKESRL-LNQEK 343
L E+ EK + E+L Q+T E RKL + + +EK ++E R+ L QE
Sbjct: 401 LREQKEKSERAAFEELEKALSTAQKT-EEARRKLKAEMDEQIKTIEKTSEEERISLQQEL 459
Query: 344 SELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRER 403
S V+Q + + +E I L + + E + ++ ER+ + K+ E+
Sbjct: 460 SR--VKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEK 517
Query: 404 QEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYE 463
+ E +Q EKE + ++E+ + K IL++ +N+L++++
Sbjct: 518 SQSEYLKISQ------EKEQQESLALEELELQ----------KKAILTESENKLRDLQ-- 559
Query: 464 LQQLEGSSDRILELDQELIKAERELS----------KAEKNSN-------VETLKMEVIS 506
Q+ E RILEL+ L K+ +E +AEKN + VE K E+ S
Sbjct: 560 -QEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELES 618
Query: 507 LQNEKADL-DRTLRKLDQ----EMEQLNHHTTTRTQMEMLTKDK-----ADKDEQIRKIK 556
L++++ L L+ L Q EME+L + E L KDK A +E K
Sbjct: 619 LKHQQDALWTEKLQVLKQQYQTEMEKLRE--KCEQEKETLLKDKEIIFQAHIEEMNEKTL 676
Query: 557 SRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKEL-ASSEQNKNH----I 611
+ + T L ++ H +E++ +D+ K+ +EL A ++ KNH +
Sbjct: 677 EKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQV 736
Query: 612 NNELKRKEEQLSSYEDKLFDVCGS------------QDFESDLDRLKEEIEKSSKQRAML 659
++ +K E + E L D ++ ++ ++ L+ +I++S +
Sbjct: 737 DSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQA 796
Query: 660 AGATAVYSQFITQLTDENQSCCPVCQRVFQTE-AELQEVISDLQSKLRLAPDKLKSTESE 718
+ V+ + QS + ++ + A+LQ+ + DL+++ L ++ E E
Sbjct: 797 SAKLDVFQSY--------QSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQV--AEVE 846
Query: 719 LKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDI-QRLKNDIEEQETLLGT 777
+KK+ + +D + ++ +L +L+ N ++ Q++K+ + E+ L
Sbjct: 847 AQKKDVCTE------------LDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLED 894
Query: 778 IMPEEESAKVCLTD-----VTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEK 832
E+E K L + + + E + E++ + +K++ + + ++ + + NQEK
Sbjct: 895 GNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEK 954
Query: 833 QEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQ---------------I 877
+ ++ K + L +KL+ + + + L++T EL ++ Q I
Sbjct: 955 KMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGI 1014
Query: 878 STNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSN 937
S + R + +++ +E TEV RE+ D + +K Q+ EEL
Sbjct: 1015 SDAVSRLETNQKEQIESLTEVHR--RELNDV------ISIWEKKLNQQAEELQEIHEIQL 1066
Query: 938 KIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKI 997
+ + ++ ++K+K+ +++ I K++ KQ +T LN++ QL + H +
Sbjct: 1067 QEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQ-DTTLNELQEQLKQKSAHVNSL 1125
Query: 998 NEDMRLMRQDIDTQKIQ-ERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSE 1056
+D ++ ++ ++ + L++N L+++ ELK + EE K+ +V ++ S+
Sbjct: 1126 AQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKR--------KVSELTSK 1177
Query: 1057 HQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFR-DAEEKYREMMIVMRTTE 1115
+ +E ++K +H + K E++ + FKK E + D K E ++ +T E
Sbjct: 1178 LKTTDEEFQSLKSSHEKS---NKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNE 1234
Query: 1116 LVN 1118
L+N
Sbjct: 1235 LIN 1237
Score = 135 bits (341), Expect = 2e-31
Identities = 225/1153 (19%), Positives = 482/1153 (41%), Gaps = 173/1153 (15%)
Query: 71 KVAQETDVRAQIRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITRTKHGEKVSLS 130
K++QE + + + L E + +Q+ + T+ K E RT+ E S
Sbjct: 524 KISQEKEQQESLAL-------EELELQKKAILTESENKLRDLQQEAETYRTRILELESSL 576
Query: 131 SKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGK----ALKQKFDEIFSATRYI 186
K + ++ L V N H ++ + + K +LK + D +++
Sbjct: 577 EKSLQENKNQSKDLAVHLEAEKNK---HNKEITVMVEKHKTELESLKHQQDALWT----- 628
Query: 187 KALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYEN 246
+ L+ L+Q QT+ +K++E K +EK ++D+ +A + E K+ E
Sbjct: 629 EKLQVLKQQYQTEMEKLRE--------KCEQEKETLLKDKEIIFQAHIEEMNE--KTLE- 677
Query: 247 ELDPLKNRLKEIEHNLSKIMKLDNEIKA-LDSRKKQMEKDNSELEEKMEKVFQGTDEQLN 305
+LD + L+ + LS+++K ++++ L K Q +K ELE KM++ +Q++
Sbjct: 678 KLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVD 737
Query: 306 DLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQE--------KSELLVEQGRLQ--- 354
+ H+ +++ E+ L D +LE L KE +E ++++ +G LQ
Sbjct: 738 SIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQAS 797
Query: 355 --------LQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEG 406
Q+ H++ + L Q L+L+ +ER + K V E +
Sbjct: 798 AKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLE-------TERIL--LTKQVAEVEAQ 848
Query: 407 EAKTANQLMNDFAEKETLKQ---KQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYE 463
+ +L + + L Q KQ E+ K L ++ E K E +K+Q + K + E
Sbjct: 849 KKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVE 908
Query: 464 -----LQQLEGSSDRILELDQELI------------------KAERELSKAEKNSN--VE 498
LQ EG I L Q+L E+++ K ++ + E
Sbjct: 909 KENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQE 968
Query: 499 TLKMEVISLQNE-KADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKS 557
TLK +++ + + K +L+ T +L Q+ +Q N +EM + A + + ++++
Sbjct: 969 TLKKKLLDQEAKLKKELENTALELSQKEKQFN-----AKMLEMAQANSAGISDAVSRLET 1023
Query: 558 RHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKR 617
+++ SL ++++L D + K++NQ + L ++++ +L+
Sbjct: 1024 NQKEQIESLTEV--HRRELNDVISIWEKKLNQQAEELQEIHE-------------IQLQE 1068
Query: 618 KEEQLSSYEDK-LFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDE 676
KE++++ + K L C ++ ++ LKEE K T L +
Sbjct: 1069 KEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQD-----------------TTLNE- 1110
Query: 677 NQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMR 736
+ +++ Q A + + D ++KL+ +KL E +L K K + +
Sbjct: 1111 ------LQEQLKQKSAHVNSLAQD-ETKLKAHLEKL---EVDLNKSLKENTFLQEQLVEL 1160
Query: 737 QSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIME 796
+ + + ++++ EL +KL+ + + Q LK+ E+ L E++S + +
Sbjct: 1161 KMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSL-----EDKSLEFKKLSEELAI 1215
Query: 797 RFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQ 856
+ + K E + + +L I +T + QH+ V + + + +
Sbjct: 1216 QLDICCKKTEALLEAKTNELINISSSKT-NAILSRISHCQHRTTKVKEALLIKTCTVSEL 1274
Query: 857 QEQIQHLKSTTNELKSEKLQISTNLQRRQ----QLEEQTVELSTEVQSLYREIKDAKEQV 912
+ Q++ L N L Q + L+ ++ ++ L TE ++L +E + ++
Sbjct: 1275 EAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAA 1334
Query: 913 SPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDY 972
S E+ + + ++E E IN + + +++L + K ++ ++ + D+ +Q+
Sbjct: 1335 SEKESCITQLKKELSENIN----AVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSIS-- 1388
Query: 973 KKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELK 1032
+KE ++ + Q E + +D+ + +KI D+ + K +E K
Sbjct: 1389 LSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWS-NKFSEWKK 1447
Query: 1033 EVEEERKQHLKEMGQMQV---LQMKSEHQK------LEENIDNIKRNHNLALGRQKG--- 1080
+ + QH + ++Q+ L+ K ++K L+E +D + + G +
Sbjct: 1448 KAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKS 1507
Query: 1081 -YEEEIIHFKKELREPQFRDAE------EKYREMMIVMRTTELVNKDLDIYYKTLDQAIM 1133
E++ + + EL+ R E +K E+ + + N+ DI +K L Q +
Sbjct: 1508 KMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQ 1567
Query: 1134 KFHSMKMEEINKI 1146
F + E+ N++
Sbjct: 1568 HFQELGEEKDNRV 1580
Score = 130 bits (327), Expect = 8e-30
Identities = 241/1140 (21%), Positives = 474/1140 (41%), Gaps = 183/1140 (16%)
Query: 103 TQKSKKTEFKTLEGVITRTKHGEKVSLSSKCAEIDREMISSLG-VSKAVLNNVIFCHQED 161
+QK K+ K LE + + S+ +E I SL V + LN+VI ++
Sbjct: 993 SQKEKQFNAKMLE--MAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKK 1050
Query: 162 SNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKAC 221
N E Q+ EI + + E L+Q G + +E E+ +LK E+
Sbjct: 1051 LNQQAEE----LQEIHEIQLQEKEQEVAE-LKQKILLFGCEKEEMNKEITWLK---EEGV 1102
Query: 222 EIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKA-LDSRKK 280
+ + + QL V S + LK L+++E +L+K +K + ++ L K
Sbjct: 1103 KQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKM 1162
Query: 281 QMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKL-------- 332
E+D ++ E K+ + TDE+ L +H+++ + E K ++ + E+L
Sbjct: 1163 LAEEDKRKVSELTSKL-KTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICC 1221
Query: 333 NKESRLLNQEKSELL-VEQGRLQLQADR--HQEH--IRARDSLIQSLATQLELDGFERGP 387
K LL + +EL+ + + R H +H + +++L+ T EL+ R
Sbjct: 1222 KKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQL 1281
Query: 388 FSERQIKNF------HKLVRERQEGEAKTAN-QLMNDFAEKETLKQKQIDEIRDKKTGLG 440
E+ N H+L E +E + K+ + + EKE L+++ ++ +
Sbjct: 1282 TEEQNTLNISFQQATHQL--EEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKES 1339
Query: 441 RIIELKSEI------LSKKQNELKNVKYELQQLEGS-SDRILELDQELIKAERELS---- 489
I +LK E+ ++ + ELK K E+ L +D ++L + +E+E +
Sbjct: 1340 CITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSL 1399
Query: 490 -------KAEKNSNVETLKMEVISLQNEK----ADLDRTLRKLDQ----EMEQLNHHTTT 534
K E V+ L +V +L EK +D K + + H T
Sbjct: 1400 RKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNT 1459
Query: 535 ----RTQMEMLTKDKADKDEQIR-------------------------KIKSRHSDELTS 565
+ Q+E+ +K+ +KDEQI K++ + S+ T
Sbjct: 1460 VKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETE 1519
Query: 566 LLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLN-------KELASSEQNKNHI----NNE 614
L +LED + K+ EI + L N KEL Q+ + +N
Sbjct: 1520 LKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNR 1579
Query: 615 LKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEK-----SSKQRAMLAGATAVYSQF 669
+K EE++ + E++++ + +++L+ K+E+E SK+ + A + S+
Sbjct: 1580 VKEAEEKILTLENQVYSM------KAELETKKKELEHVNLSVKSKEEELKALEDRLESES 1633
Query: 670 ITQLTD----ENQSCCPVCQRVFQTEAELQEV--------ISDLQSKLRLAPDKLKSTES 717
+L + Q + +++ E +E +S+L +KL+ ++ E
Sbjct: 1634 AAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEE 1693
Query: 718 ELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRD-IQRLKNDIEEQETLLG 776
+LK E + E L + +++ E+E + + +Q + I L+ ++ E+E LL
Sbjct: 1694 KLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQ 1753
Query: 777 TIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQ 836
+ E+E T+ F+M + ER I + A+ + + + + +E +EK
Sbjct: 1754 RVGQEKEE--------TVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKN 1805
Query: 837 HKLDTV----------SSKIELNRKL---IQDQQEQIQHLKSTTNELKSEKLQISTNLQR 883
K + + I+ + L D Q+ +Q + T L+ + ++ + L R
Sbjct: 1806 KKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVR 1865
Query: 884 RQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQE-KEELINKKNTSNKIAQD 942
++++ +E T + ++ + P E E +++ K L+ K SN AQ
Sbjct: 1866 QKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQH 1925
Query: 943 KLNDIKEKV-----------KNIHGYMKDIENYIQDGKDD---YKKQKETELNKVIAQLS 988
ND++ K+ K I KD+ ++ + + KK+ + E + I Q
Sbjct: 1926 --NDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQ-- 1981
Query: 989 ECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEE-RKQHLKEMGQ 1047
E E + K N ++ + ++ +TQ Q+ + +T+++ + +EVE E + H +E Q
Sbjct: 1982 EQEDLELKHNSTLKQLMREFNTQLAQKE-QELEMTIKETINKAQEVEAELLESHQEETNQ 2040
Query: 1048 MQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREM 1107
+ +K+ E D++KR K Y EEI+ ++E + RD + + E+
Sbjct: 2041 LL--------KKIAEKDDDLKRT-------AKRY-EEILDAREEEMTAKVRDLQTQLEEL 2084
Score = 97.8 bits (242), Expect = 6e-20
Identities = 141/693 (20%), Positives = 302/693 (43%), Gaps = 102/693 (14%)
Query: 491 AEKNSNVETLKMEVISLQNEKADLDRTLRK------LDQEMEQLNHHTTTRTQMEMLTKD 544
+ K S V T E ++ + DLD + +D E E L ++ + + +++ +
Sbjct: 88 SSKESLVRTSSRESLN----RLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRL 143
Query: 545 KADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASS 604
+ + + + ++S+ +T+ KK+L+ L S+ +++ R+A+L +EL
Sbjct: 144 RR-MERSLSSYRGKYSELVTAYQMLQREKKKLQGIL---SQSQDKSLRRIAELREELQMD 199
Query: 605 EQNKNHINNE----LKRKEE-------QLSSYEDKLFDVCGSQDFESDLDRL-------- 645
+Q K H+ E L+ K++ Q+S + +L + + D L +L
Sbjct: 200 QQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFT 259
Query: 646 KEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAE-----------L 694
KEE +S + + G + + + Q ++ C+ Q+ E L
Sbjct: 260 KEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEAL 319
Query: 695 QEVISDLQSKLRLAPD-------KLKSTESELKKKEKRRDEMLGLV-----PMRQSIIDL 742
QE + + +L D KL + + K ++ ++ G+V +++
Sbjct: 320 QEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEM 379
Query: 743 KEKEIPELRNKLQNVNRDIQRLKND--------IEEQETLLGTIMPEEESAKVCLTDVTI 794
KE+EI +LR++++ + + L+ EE E L T EE+ + ++
Sbjct: 380 KEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDE 439
Query: 795 MERFQMELKDVERKIAQQ---AAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRK 851
+ + + ER QQ K + +D+ + + K +K H+ + + EL +K
Sbjct: 440 QIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKK 499
Query: 852 LIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVEL---------STEVQSLY 902
L ++E + +K + +SE L+IS ++++ L + +EL +++ L
Sbjct: 500 LQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQ 559
Query: 903 REIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIE 962
+E + + ++ LE++LEK QE + K+ + + +K KE + + ++E
Sbjct: 560 QEAETYRTRILELESSLEKSLQENKN--QSKDLAVHLEAEKNKHNKEITVMVEKHKTELE 617
Query: 963 N--YIQDG-----KDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQ---DIDTQK 1012
+ + QD K+Q +TE+ K+ +CE+ KE + +D ++ Q + +K
Sbjct: 618 SLKHQQDALWTEKLQVLKQQYQTEMEKL---REKCEQEKETLLKDKEIIFQAHIEEMNEK 674
Query: 1013 IQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQM--------QVLQMKSEHQK--LEE 1062
E+ L + EL EV + R + +E+ + Q L+ K + QK ++
Sbjct: 675 TLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQ 734
Query: 1063 NIDNIKRNHNLALGR-QKGYEEEIIHFKKELRE 1094
+D+I + H +++ R +K +++I + L+E
Sbjct: 735 QVDSIIKEHEVSIQRTEKALKDQINQLELLLKE 767
Score = 84.3 bits (207), Expect = 7e-16
Identities = 146/695 (21%), Positives = 291/695 (41%), Gaps = 109/695 (15%)
Query: 204 KEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELD-------------- 249
KE +E + LK + E+ D IT K ++ S E++K+Y + D
Sbjct: 1512 KESNLETE-LKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQ 1570
Query: 250 ----PLKNRLKEIEHNLSKIMKLDNEIKA----LDSRKKQMEKDNSELEEKMEKVFQGTD 301
NR+KE E KI+ L+N++ + L+++KK++E N ++ K E++ D
Sbjct: 1571 ELGEEKDNRVKEAEE---KILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALED 1627
Query: 302 EQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQ 361
++ R+ E+K+ ++L +E ++ +E + + +LQ +
Sbjct: 1628 RLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERERE 1687
Query: 362 EHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEK 421
HI + L ++Q E R KN + ++ EA + + + EK
Sbjct: 1688 VHI-LEEKLKSVESSQSET------LIVPRSAKN---VAAYTEQEEADSQGCVQKTYEEK 1737
Query: 422 ETLKQKQIDEIRDKKTGLGRIIELKSEILSKK-----QNELKNVKYELQQLEGSSDRIL- 475
++ Q+ + E K+ L R+ + K E +S Q + + +K E + + D+ +
Sbjct: 1738 ISVLQRNLTE---KEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMI 1794
Query: 476 -ELDQELIKAERELS-----KAEKNSNVETLKMEVISLQNEKADLDRTLRK-------LD 522
L +EL + ++ S EK ++ + +L+N D+ +TL++ L+
Sbjct: 1795 GHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQ-NLENVFDDVQKTLQEKELTCQILE 1853
Query: 523 QEMEQLN-----HHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLE 577
Q++++L+ R +ME LT K +K + ++++ R+ T LL +K
Sbjct: 1854 QKIKELDSCLVRQKEVHRVEMEELTS-KYEKLQALQQMDGRNKP--TELLEENTEEKSKS 1910
Query: 578 DWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQD 637
+ K ++ + L +LA +E+ K + E+ R ++ L ++
Sbjct: 1911 HLVQPKL--LSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLR---------KE 1959
Query: 638 FESDLDRLKEEI--EKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQ 695
+ +L+ LK+E E+ K + ++ + QL E + + Q+ + E ++
Sbjct: 1960 HQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNT--QLAQKEQELEMTIK 2017
Query: 696 EVISDLQS-KLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKL 754
E I+ Q + L + T LKK ++ D++ + I+D +E+E+ L
Sbjct: 2018 ETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDL 2077
Query: 755 QNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAA 814
Q ++Q+ EQE G +VTIME ++ ++AQ+
Sbjct: 2078 QTQLEELQKKYQQKLEQEENPGN------------DNVTIME--------LQTQLAQKTT 2117
Query: 815 KLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELN 849
+ L QE +E+ H L+ K E N
Sbjct: 2118 LISDSKLK------EQEFREQIHNLEDRLKKYEKN 2146
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 144 bits (363), Expect = 6e-34
Identities = 195/989 (19%), Positives = 432/989 (43%), Gaps = 110/989 (11%)
Query: 234 LTSSKEIVKSYENELDPLKNRLKEIEHNLS----KIMKLDNEIKALDSRKKQMEKDNSEL 289
L S+ E+ K YE D + E NL+ + L E++ L + K+ + + EL
Sbjct: 50 LGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEEL 109
Query: 290 EEKMEKVFQGTDEQL---NDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSEL 346
++++EK +QG +Q + L + ++ E++L + E + + L Q+ ++L
Sbjct: 110 KKELEK-YQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQL 168
Query: 347 LVEQGRLQLQADRHQEHIRARDSLIQSLATQLE-----LDGFERGPFSERQIKNFHKLVR 401
E ++ + D + A + + L +L + + I++ L +
Sbjct: 169 ATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKK 228
Query: 402 ERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVK 461
E + + N + E E LK + + I +L+SE L+K E+
Sbjct: 229 ELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSE-LAKGPQEVAVYV 287
Query: 462 YELQQLEGSSDRILE----LDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRT 517
ELQ+L+ S + + + L + L+K E++ +K E+ N E++ K ++ T
Sbjct: 288 QELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVS---------KKNIQAT 338
Query: 518 LRKLDQEMEQLNHH-TTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQL 576
L + D + +QL + + T + + + ++K E +K+K S+ T KQL
Sbjct: 339 LHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQL 398
Query: 577 EDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGS- 635
+ K + Q + + +L+ +L +E+ + LK ++ QLSS +KL D
Sbjct: 399 QQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLK-EQRQLSS--EKLMDKEQQV 455
Query: 636 QDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQ 695
D + L RL+E++++ + +T + Q + + ++Q + Q T A+L+
Sbjct: 456 ADLQLKLSRLEEQLKEK------VTNSTELQHQ-LDKTKQQHQEQQALQQ---STTAKLR 505
Query: 696 EVISDLQSKLRLAPDK----------LKSTESELKKKEKRRDEMLGLVPMRQS----IID 741
E +DL+ LR DK L+ ++ + EK R+++ + + +
Sbjct: 506 EAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ 565
Query: 742 LKEK------EIPELRNKLQNVNRDIQRLKNDIEEQ------------------ETLLGT 777
L+EK ++ +L KL+N + ++ + ++ +Q ET +
Sbjct: 566 LQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNE 625
Query: 778 IMPE--EESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEK 835
+ + E KV D+ I + ++ L K AQ+A DL + Q+K
Sbjct: 626 LNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRA------DLQNHLDTAQNALQDK 679
Query: 836 QHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQ----QLEEQT 891
Q +L+ ++++++ +QD+QE L+S E K + L + + + +LE +
Sbjct: 680 QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADS 739
Query: 892 VELSTEVQSLYREIKDAKEQVSPLE---TTLEKFQQEKEELINKKNTSNKIAQDKLNDIK 948
+E+ + ++++ ++ + LE T L K + ++E+++ + + L IK
Sbjct: 740 LEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIK 799
Query: 949 EKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKV---IAQLSECEKHKEKINEDMRLMR 1005
+K+ + ++ + + K Q E N++ + +L + + KE + ++ ++
Sbjct: 800 QKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK 859
Query: 1006 QDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKS---EHQKLEE 1062
+ K+ + K N++ K + ++ KE+ +QM++ E ++L++
Sbjct: 860 DKL--SKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKK 917
Query: 1063 NIDNIKR-NHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDL 1121
+++ K +H L L +E++I + L++ + ++ ++ + + +++E K +
Sbjct: 918 SLEKEKEASHQLKL-ELNSMQEQLIQAQNTLKQNE-KEEQQLQGNINELKQSSEQKKKQI 975
Query: 1122 DIYYKTLDQAIMKFHSMKMEEINKIIRDL 1150
+ L A+++ K E NK+ + L
Sbjct: 976 EALQGELKIAVLQ----KTELENKLQQQL 1000
Score = 138 bits (348), Expect = 3e-32
Identities = 216/1091 (19%), Positives = 462/1091 (42%), Gaps = 116/1091 (10%)
Query: 71 KVAQETDVRAQIRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITRTKHGEKVSLS 130
K QE V Q + + EL +++ K+ ++ LE KH E+ S+S
Sbjct: 278 KGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLE-----EKHNEE-SVS 331
Query: 131 SKCAEID--------REMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSA 182
K + +++ S L S+ L+ + H E S + K LK++ E+ +
Sbjct: 332 KKNIQATLHQKDLDCQQLQSRLSASETSLHRI---HVELSEKGEATQK-LKEELSEVETK 387
Query: 183 TRYIKA-LETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEI- 240
+++KA + L+Q R+ + Q + Q E+ Q K E Q+ +L +++
Sbjct: 388 YQHLKAEFKQLQQQREEKEQHGLQLQSEIN---QLHSKLLETERQLGEAHGRLKEQRQLS 444
Query: 241 ---VKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVF 297
+ E ++ L+ +L +E L + + E++ + KQ ++ L++
Sbjct: 445 SEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKL 504
Query: 298 QGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQA 357
+ L + R + +K++K+ + L+K + LL +E+ +L + +QA
Sbjct: 505 REAQNDLEQVL----RQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAK-----IQA 555
Query: 358 DRHQ----EHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQ 413
+ ++ ++ +Q TQL + ++ +N H V+E Q+ + A
Sbjct: 556 GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQE-QKAHLRAAQD 614
Query: 414 LMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEIL-----------SKKQNELKNVKY 462
+ Q++E ++K + L I+ K+E+L + QN L +
Sbjct: 615 RVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQN 674
Query: 463 ELQQLEGSSDRIL-ELDQELIKAE-RELSKAEKNSNVETLKMEVISLQNEKADLDRTLRK 520
LQ + ++I +LDQ K + ++ ++ S+++ K + +SL+ + +L+ ++K
Sbjct: 675 ALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKK 734
Query: 521 LD-----------QEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKS-------RHSDE 562
L+ Q ++ L T +E+ + + + E ++I S + S+
Sbjct: 735 LEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEA 794
Query: 563 LTSLLGYFPNKKQLEDWLHSKSKEINQ-TRDRLAKLNKELASSEQNKNHINNELKRKEEQ 621
L S+ +++ + L + ++Q T+ + +LN + ++ + E + +
Sbjct: 795 LESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTE 854
Query: 622 LSSYEDKLFDVCGSQDFESDLDRLKEEIEKSS-KQRAMLAGATAVYSQFITQLTDENQSC 680
LS+ +DKL V S L K E EK + K +A + + QL + ++
Sbjct: 855 LSTVKDKLSKVSDS------LKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENT 908
Query: 681 CPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSII 740
+ + ++ + +E L+ +L ++L ++ LK+ EK ++ G + +
Sbjct: 909 LKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSS 968
Query: 741 DLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLG-TIMPEEESAKVCLTDVTIMERFQ 799
+ K+K+I L+ +L+ L+N +++Q T + E+E V + E+ Q
Sbjct: 969 EQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN---YEKSQ 1025
Query: 800 MELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQ 859
K ++ + ++L Q+ + + KL + NR I +Q +
Sbjct: 1026 ETFKQLQSDFYGRESELLA---------TRQDLKSVEEKLSLAQEDLISNRNQIGNQNKL 1076
Query: 860 IQHLKSTTNELKSEKLQISTNLQRR-QQLEEQTVELSTEVQSLYR------EIKDAK--- 909
IQ LK+ L+ + + LQ R + L++ E S + + L EI++ K
Sbjct: 1077 IQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQ 1136
Query: 910 -EQVSPLETTLEKFQQEK-EELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQD 967
++++ L L+ + E +E+ N K+ + Q KL +++ K ++ ++ + Q
Sbjct: 1137 EKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKL-ELQGKADSLKAAVEQEKRNQQI 1195
Query: 968 GKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKR 1027
KD KK++E EL K + E + H E + +++ +K +E + + +
Sbjct: 1196 LKDQVKKEEE-ELKKEFIE-KEAKLHSE-------IKEKEVGMKKHEENEAKLTMQITAL 1246
Query: 1028 NEELKEVEEERKQHLKEMGQM--QVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEI 1085
NE L V++E + + + ++ Q ++ E LE + N + L R E EI
Sbjct: 1247 NENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEI 1306
Query: 1086 IHFKKELREPQ 1096
+ ++ E Q
Sbjct: 1307 EKLQTKVLELQ 1317
Score = 94.4 bits (233), Expect = 7e-19
Identities = 131/592 (22%), Positives = 259/592 (43%), Gaps = 59/592 (9%)
Query: 131 SKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYI-KAL 189
SK E+++E++SS + + + ++ E + LKQ F+ + T+ + L
Sbjct: 771 SKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEEL 830
Query: 190 ETLRQVRQTQGQKVK-EYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENEL 248
Q T+ QKVK E + + L K+K ++ D + + +++ KE K L
Sbjct: 831 NNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEF--EKENQKGKAAIL 888
Query: 249 DPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLY 308
D L+ KE++H L ++++N +K KK +EK+ E +++ EQL
Sbjct: 889 D-LEKTCKELKHQLQ--VQMENTLKEQKELKKSLEKEK-EASHQLKLELNSMQEQLIQA- 943
Query: 309 HNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARD 368
Q T+++ E++ + +L + S Q+K ++ QG L++ + E
Sbjct: 944 ---QNTLKQNEKEEQQLQGNINELKQSSE---QKKKQIEALQGELKIAVLQKTELENKLQ 997
Query: 369 SLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDF--AEKETLKQ 426
+ A +L + K +++ E +T QL +DF E E L
Sbjct: 998 QQLTQAAQELAAE------------KEKISVLQNNYEKSQETFKQLQSDFYGRESELLAT 1045
Query: 427 KQIDEIRDKKTGLGR--IIELKSEILSKKQ--NELKNVKYELQQLEGSSDRILELDQELI 482
+Q + ++K L + +I +++I ++ + ELK K L+Q ++ L QE
Sbjct: 1046 RQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQL---QERC 1102
Query: 483 KAERELSKAE--KNSNVETLKMEVISLQNEKADLDRTLRKLDQEM-----EQLNHHTTTR 535
KA +++ K + K + K ++ ++ K ++ + KL++E+ E + T +
Sbjct: 1103 KALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLK 1162
Query: 536 TQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTR-DRL 594
++L + K + + +K+ E N++ L+D + + +E+ + ++
Sbjct: 1163 DAKQLLIQQKLELQGKADSLKAAVEQEKR-------NQQILKDQVKKEEEELKKEFIEKE 1215
Query: 595 AKLNKELASSEQN-KNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSS 653
AKL+ E+ E K H NE K Q+++ + L V ++++S R+ E
Sbjct: 1216 AKLHSEIKEKEVGMKKHEENEAKLTM-QITALNENLGTV--KKEWQSSQRRVSE----LE 1268
Query: 654 KQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKL 705
KQ L G AV + DE ++ C + +LQ + +LQ KL
Sbjct: 1269 KQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKL 1320
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 144 bits (362), Expect = 7e-34
Identities = 212/1072 (19%), Positives = 456/1072 (42%), Gaps = 175/1072 (16%)
Query: 186 IKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYE 245
IK L + + +E+Q L + + K E+ +++ + L ++ +
Sbjct: 839 IKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVT---LLKEKNDLQLQVQ 895
Query: 246 NELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLN 305
+E D L + + E + ++L+ +IK + R ++ E+ N+EL K K+ E
Sbjct: 896 SEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKK 955
Query: 306 DLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIR 365
D+ + + T+ + E++ +++ L +E L++ ++L E+ LQ + + ++
Sbjct: 956 DI-DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQ 1014
Query: 366 ARDSLIQSLA---TQLE--LDGFERGPFSERQIKNFHKLVRERQEGEAKTA--------- 411
A + + L T+LE +D E E++++ + + + EG+ K A
Sbjct: 1015 AEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMEN 1074
Query: 412 -NQLMNDFAEKETLK------------------QKQIDEIRDKKTGLGRIIELK--SEIL 450
Q +++ EK+ + QK+I E++ + LG IE + S
Sbjct: 1075 DKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAK 1134
Query: 451 SKKQ-----NELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKME-- 503
++KQ EL+ + L++ G++ +EL++ K E E K ++ TL+ E
Sbjct: 1135 AEKQRSDLSRELEEISERLEEAGGATSAQVELNK---KREAEFQKLRRDLEEATLQHEAM 1191
Query: 504 VISLQNEKAD-----------LDRTLRKLDQEMEQLNHHT-TTRTQMEMLTKDKAD---- 547
V +L+ + AD L R +KL++E +L T + E ++K K +
Sbjct: 1192 VAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKM 1251
Query: 548 ---KDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASS 604
++Q+ ++K++ ++ + + +L+ S+++++ +++L++ +S
Sbjct: 1252 CRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAS 1311
Query: 605 EQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATA 664
Q + ++L+ + + ++ L Q D D L+E+ E+ + +A L A +
Sbjct: 1312 TQQIEELKHQLEEETKAKNALAHAL------QSSRHDCDLLREQYEEEQEGKAELQRALS 1365
Query: 665 VYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEK 724
+ + Q + ++ Q EL+E L +L+ A + +++ ++ EK
Sbjct: 1366 KANSEVAQWRTKYET------DAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEK 1419
Query: 725 RRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEES 784
+ + V ++ L K +N ++ + K EE + L E S
Sbjct: 1420 TKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRS 1479
Query: 785 AKVCLTDVTIM---------------ERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVN 829
L V + + Q E+ D+ +IA+ ++ +L++ +QV
Sbjct: 1480 LSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIH--ELEKIKKQVE 1537
Query: 830 QEKQEKQHKLDTVSS------------KIELNR------KLIQDQQEQIQHLK------- 864
QEK E Q L+ + ++ELN+ + I ++ E+I LK
Sbjct: 1538 QEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVV 1597
Query: 865 ----STTN-ELKSEKLQISTNLQRRQQLEEQTVELS-------------TEVQSLYREI- 905
ST + E++S + + L E ++L+ Q + +E
Sbjct: 1598 ETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQ 1657
Query: 906 ----------KDAKEQVSPLETTLEKFQQEKEEL---INKKNTSNKIAQDKLNDIKEKVK 952
+D KEQ++ +E Q E EEL + + S KIA+ +L D E+V+
Sbjct: 1658 LHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQ 1717
Query: 953 NIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDI---- 1008
+H + N + ++D Q ++E+ +VI + E+ +K D +M +++
Sbjct: 1718 LLHTQNTSLINTKKKLENDV-SQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQ 1776
Query: 1009 DTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDN-I 1067
DT ER ++ L + ++L+ +E +Q + G+ Q+ ++++ ++LE ++N
Sbjct: 1777 DTSAHLERMKKN---LEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQ 1833
Query: 1068 KRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNK 1119
KRN G +K ++ ++E ++ E++ V+R +LV+K
Sbjct: 1834 KRNAEAVKGLRK--------HERRVKELTYQTEEDRKN----VLRLQDLVDK 1873
Score = 134 bits (337), Expect = 6e-31
Identities = 225/1083 (20%), Positives = 445/1083 (41%), Gaps = 216/1083 (19%)
Query: 190 ETLRQVRQTQGQKVK-EYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENEL 248
++L + Q +K + Q+E K +K+ E+A E ++I A+LT+ K + E+E
Sbjct: 899 DSLADAEERCEQLIKNKIQLEAK-IKEVTERA-EEEEEIN---AELTAKK---RKLEDEC 950
Query: 249 DPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLY 308
LK + ++E L+K+ K E A +++ K + ++ + L+E + K+ ++ L
Sbjct: 951 SELKKDIDDLELTLAKVEK---EKHATENKVKNLTEEMAGLDETIAKL----SKEKKALQ 1003
Query: 309 HNHQRTVREKERKLVDCHRELEKLN---KESRLLNQEKSEL---LVEQGRLQLQADRHQE 362
HQ+T L D E +K+N K L Q+ +L L ++ +L++ +R +
Sbjct: 1004 ETHQQT-------LDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKR 1056
Query: 363 HIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKE 422
+ L Q +E D ++Q+ KL E++E E + D E
Sbjct: 1057 KLEGDLKLAQESTMDMEND--------KQQLDE--KL--EKKEFEISNLISKIEDEQAVE 1104
Query: 423 TLKQKQIDEIRDKKTGLGRIIELK--SEILSKKQN-----ELKNVKYELQQLEGSSDRIL 475
QK+I E++ + LG IE + S ++KQ EL+ + L++ G++ +
Sbjct: 1105 IQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQV 1164
Query: 476 ELDQELIKAERELSKAEKNSNVETLKME--VISLQNEKAD-----------LDRTLRKLD 522
EL++ K E E K ++ TL+ E V +L+ + AD L R +KL+
Sbjct: 1165 ELNK---KREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLE 1221
Query: 523 QEMEQLNHHTTT-RTQMEMLTKDKADKD-------EQIRKIKSRHSDELTSLLGYFPNKK 574
+E +L T + E ++K K + + +Q+ ++K++ ++ + +
Sbjct: 1222 KEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRA 1281
Query: 575 QLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCG 634
+L+ S+++++ +++L++ +S Q + ++L+ + + ++ L
Sbjct: 1282 RLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHAL----- 1336
Query: 635 SQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAEL 694
Q D D L+E+ E+ + +A L A + + + Q + ++ Q EL
Sbjct: 1337 -QSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYET------DAIQRTEEL 1389
Query: 695 QEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKL 754
+E L +L+ A + +++ ++ EK + + V ++ L K
Sbjct: 1390 EEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQ 1449
Query: 755 QNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIM---------------ERFQ 799
+N ++ + K EE + L E S L V + + Q
Sbjct: 1450 RNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQ 1509
Query: 800 MELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSS------------KIE 847
E+ D+ +IA+ ++ +L++ +QV QEK E Q L+ + ++E
Sbjct: 1510 QEISDLTEQIAEGGKQIH--ELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLE 1567
Query: 848 LNR------KLIQDQQEQIQHLK-----------STTN-ELKSEKLQISTNLQRRQQLEE 889
LN+ + I ++ E+I LK ST + E++S + + L E
Sbjct: 1568 LNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNE 1627
Query: 890 QTVELS-------------TEVQSLYREIK-----------DAKEQVSPLETTLEKFQQE 925
++L+ Q + +E + D KEQ++ +E Q E
Sbjct: 1628 MEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAE 1687
Query: 926 KEEL---INKKNTSNKIAQDKLNDIKEKVKNIHGY------------------MKDIENY 964
EEL + + S KIA+ +L D E+V+ +H ++E
Sbjct: 1688 IEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEV 1747
Query: 965 IQDGKDDYKKQKET---------ELNKVIAQLSECEKHKEKINEDMRLMRQDIDT----- 1010
IQ+ ++ +K K+ EL K + E+ K+ + + ++ ++ +D
Sbjct: 1748 IQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLA 1807
Query: 1011 --------QKI--------------QERWLQDNLTLRKRNEELKEV----EEERKQHLKE 1044
QK+ Q+R + LRK +KE+ EE+RK L+
Sbjct: 1808 LKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRL 1867
Query: 1045 MGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKY 1104
+ LQ K + K + + N NL+ R+ +E E + ++ E Q K
Sbjct: 1868 QDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKS 1927
Query: 1105 REM 1107
RE+
Sbjct: 1928 REV 1930
Score = 117 bits (293), Expect = 7e-26
Identities = 189/894 (21%), Positives = 370/894 (41%), Gaps = 144/894 (16%)
Query: 314 TVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIR-ARDSLIQ 372
T++E+ +K D EL K + + L ++ LL E+ LQLQ + + A + Q
Sbjct: 854 TMKEEFQKTKD---ELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQ 910
Query: 373 SLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEI 432
+ +++L E +IK + E +E A+ + E LK K ID++
Sbjct: 911 LIKNKIQL---------EAKIKEVTERAEEEEEINAELTAKKRKLEDECSELK-KDIDDL 960
Query: 433 --------RDKKTGLGRIIELKSEI---------LSKKQNELKNVKYE-LQQLEGSSDRI 474
++K ++ L E+ LSK++ L+ + L L+ D++
Sbjct: 961 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKV 1020
Query: 475 LELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKA---DLDRTLRKLDQEMEQLNHH 531
L + K E+++ E SL+ EK DL+R RKL+ +++
Sbjct: 1021 NILTKAKTKLEQQVDDLEG------------SLEQEKKLRMDLERAKRKLEGDLKLAQES 1068
Query: 532 TTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTR 591
T M+M DK DE++ K + E+++L+ +++ +E L K KE+
Sbjct: 1069 T-----MDM-ENDKQQLDEKLEKKEF----EISNLISKIEDEQAVEIQLQKKIKELQA-- 1116
Query: 592 DRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEK 651
R+ +L +E+ + ++ + +L ++L + G+ + +L++ +E +
Sbjct: 1117 -RIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREA--E 1173
Query: 652 SSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDK 711
K R L AT + + L ++ + AEL E I +LQ K
Sbjct: 1174 FQKLRRDLEEATLQHEAMVAALRKKHAD----------SMAELGEQIDNLQR----VKQK 1219
Query: 712 LKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQ 771
L+ +SELK + + + ++ + + + ++L+ + QRL ND+ Q
Sbjct: 1220 LEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQ 1279
Query: 772 ETLLGTIMPEEESAKVCLTDVTIMERFQMELKDV---ERKIAQQAAKLQGIDLDRTVQQV 828
L T E Q++ KD + ++QA+ Q +L +++
Sbjct: 1280 RARLQTEAGEYSR--------------QLDEKDALVSQLSRSKQASTQQIEELKHQLEEE 1325
Query: 829 NQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTN-----LQR 883
+ K H L + +L R+ +++QE L+ ++ SE Q T +QR
Sbjct: 1326 TKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQR 1385
Query: 884 RQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDK 943
++LEE +L+ +Q ++ + + LE T ++ Q E E+L+ SN
Sbjct: 1386 TEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACA-- 1443
Query: 944 LNDIKEKVKNIHGYMKDIENYIQDGKDDYK-KQKE-----TELNKVIAQLSECEKHKEKI 997
+ +K +N + + + ++ + + + QKE TEL KV E E +
Sbjct: 1444 --ALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETL 1501
Query: 998 NEDMRLMRQDI---------------DTQKIQERWLQDNLTLRKRNEELKEVEEERKQHL 1042
+ + ++Q+I + +KI+++ Q+ ++ EE + E + +
Sbjct: 1502 RRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKI 1561
Query: 1043 KEMGQMQVLQMKSEHQK----LEENIDNIKRNHNLAL-GRQKGYEEEI------IHFKKE 1091
+ Q+++ Q+KSE + +E ID +KRNH + Q + EI + KK+
Sbjct: 1562 LRI-QLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKK 1620
Query: 1092 LR------EPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMK 1139
+ E Q A E + R T+ + K+ ++ LD A+ +K
Sbjct: 1621 MEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLH---LDDALRGQEDLK 1671
Score = 70.5 bits (171), Expect = 1e-11
Identities = 122/602 (20%), Positives = 256/602 (42%), Gaps = 92/602 (15%)
Query: 201 QKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEH 260
Q+ +E + K L Q ++A E + + +K A L +K+ + +NE++ L + ++E
Sbjct: 1384 QRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRL---QNEVEDL---MLDVER 1437
Query: 261 NLSKIMKLD----NEIKALDSRKKQMEKDNSELEE-------------KMEKVFQGTDEQ 303
+ + LD N K L K++ E+ +ELE K++ V++ + +Q
Sbjct: 1438 SNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQ 1497
Query: 304 LNDLYH---NHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRH 360
L L N Q+ + + ++ + +++ +L K + + QEK E+ Q L+ +A+
Sbjct: 1498 LETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEI---QAALE-EAEAS 1553
Query: 361 QEHIRARDSLIQSLATQLELDGFERGPFSER---QIKNFHKLVRERQEGEAKTANQLMND 417
EH + IQ Q++ + + + Q+K H V E + + ND
Sbjct: 1554 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRND 1613
Query: 418 FAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILEL 477
+K+K ++ + + L L +E L +N + L++ + D L
Sbjct: 1614 ALR---VKKKMEGDLNEMEIQLNHANRLAAESL----RNYRNTQGILKETQLHLDDALRG 1666
Query: 478 DQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLD----QEMEQLNH--H 531
++L + +L+ E+ +N+ ++E + E+ + R + + + E QL H +
Sbjct: 1667 QEDL---KEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQN 1723
Query: 532 TTTRTQMEMLTKDKADKDEQIRKI--KSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQ 589
T+ + L D + ++ ++ +SR+++E KK + D ++E+ +
Sbjct: 1724 TSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKA--------KKAITD-AAMMAEELKK 1774
Query: 590 TRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEI 649
+D A L + + EQ + + L E+ K Q E+ + L+ E+
Sbjct: 1775 EQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQI-----QKLEARVRELEGEV 1829
Query: 650 EKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAE------LQEVISDLQS 703
E K+ A + + + +LT +QTE + LQ+++ LQ+
Sbjct: 1830 ENEQKRNAEAVKGLRKHERRVKELT-------------YQTEEDRKNVLRLQDLVDKLQA 1876
Query: 704 KL----RLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNR 759
K+ R A + + + + L K K + E+ + D+ E ++ +LR K + V+
Sbjct: 1877 KVKSYKRQAEEAEEQSNANLSKFRKLQHEL----EEAEERADIAESQVNKLRVKSREVHT 1932
Query: 760 DI 761
I
Sbjct: 1933 KI 1934
Score = 38.9 bits (89), Expect = 0.033
Identities = 49/263 (18%), Positives = 118/263 (44%), Gaps = 20/263 (7%)
Query: 892 VELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKV 951
++L +++ L + + KE + T E+FQ+ K+EL K K ++K+ + ++
Sbjct: 833 MKLFFKIKPLLKSAETEKE----MATMKEEFQKTKDELA-KSEAKRKELEEKMVTLLKEK 887
Query: 952 KNIHGYMKDIENYIQDGKDDYKK--QKETELNKVIAQLSECEKHKEKINEDMRLMRQDID 1009
++ ++ + + D ++ ++ + + +L I +++E + +E+IN ++ ++ ++
Sbjct: 888 NDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLE 947
Query: 1010 TQKIQ-ERWLQD-NLTLRKRNEELKEVEEERKQHLKEMGQMQ--VLQMKSEHQKLEENID 1065
+ + ++ + D LTL K +E E + K +EM + + ++ E + L+E
Sbjct: 948 DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQE--- 1004
Query: 1066 NIKRNHNLALGRQKGYEEE--IIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDI 1123
H L + E++ I+ K E Q D E + + E + L+
Sbjct: 1005 ----THQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEG 1060
Query: 1124 YYKTLDQAIMKFHSMKMEEINKI 1146
K ++ M + K + K+
Sbjct: 1061 DLKLAQESTMDMENDKQQLDEKL 1083
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 143 bits (361), Expect = 9e-34
Identities = 175/1007 (17%), Positives = 437/1007 (43%), Gaps = 129/1007 (12%)
Query: 213 LKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNR-------LKEIEHNLSKI 265
+ Y ++ +++++I E + +KE ++ ENE + L ++ LK ++ ++K+
Sbjct: 1835 INNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKM 1894
Query: 266 MKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDC 325
L+ +I+ SR ++++ E ++ +E+ +LN N+ + V + + K
Sbjct: 1895 NLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELL 1954
Query: 326 HRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFER 385
E++ L K L +EK +L+ E + +++++ +E++ ++ G ++
Sbjct: 1955 ESEMKNLKKCVSELEEEKQQLVKE--KTKVESEIRKEYLE-------------KIQGAQK 1999
Query: 386 GPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIEL 445
P ++ K +L++E+Q+ E K + + EK + ++ + + +T + +E+
Sbjct: 2000 EPGNKSHAKELQELLKEKQQ-EVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEI 2058
Query: 446 KSEILS-------KKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVE 498
E L+ K Q EL + K L + + R+L A+ K E SN E
Sbjct: 2059 TKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVL--------ADNLKLKKELQSNKE 2110
Query: 499 TLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKA------------ 546
++K + ++ + DL+R L + ++ + L + +++ L ++K
Sbjct: 2111 SVKSQ---MKQKDEDLERRLEQAEE--KHLKEKKNMQEKLDALRREKVHLEETIGEIQVT 2165
Query: 547 --DKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASS 604
KD+++++++ +T L + + L+D + + I++ + K + + S
Sbjct: 2166 LNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD---DRDRVIDEAKKWERKFSDAIQSK 2222
Query: 605 EQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATA 664
E+ E++ KE+ S +D+L + ++ LK I + + +
Sbjct: 2223 EE-------EIRLKEDNCSVLKDQL------RQMSIHMEELKINISRLEHDKQIWESKAQ 2269
Query: 665 VYSQFITQLTD----ENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELK 720
Q ++ D EN+ + Q ++ L+S+L+ D+L + L+
Sbjct: 2270 TEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLE 2329
Query: 721 KKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIE-EQETLLGTIM 779
K ++++ + G++ +++ I + +L LQ RL +I +++ ++ +
Sbjct: 2330 KCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLS 2389
Query: 780 PEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLD--RTVQQVNQEKQE-KQ 836
+EE+ +V + + + ++ E+K++E ++Q+ + ++ + + V + NQ + K
Sbjct: 2390 GKEEAIQVAIAE--LRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKT 2447
Query: 837 HKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVE--- 893
K + + K +L+ + Q + + + E+ +S L++ Q ++E E
Sbjct: 2448 IKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNK 2507
Query: 894 LSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNT-----------SNKIAQD 942
L E++ L + D + + L+ L +++++ ++I K++ NK ++
Sbjct: 2508 LKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELEN 2567
Query: 943 KLNDIKEKVKNIHGYMKDIE---NYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINE 999
K ++EK+K +D+ N +Q+ K D K E+ + +S+ + + E
Sbjct: 2568 KYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSK----EIESLKVSISQLTRQVTALQE 2623
Query: 1000 DMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEE----RKQHLKEMGQMQVLQMKS 1055
+ L + +E + + + + E+EEE +K+ K++G+++
Sbjct: 2624 EGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIE------ 2677
Query: 1056 EHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFR-------------DAEE 1102
KL++ + ++ + + + EE + ++L E + + +
Sbjct: 2678 --DKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQS 2735
Query: 1103 KYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRD 1149
R M + + + N++LD + D ++ + +K + + RD
Sbjct: 2736 FGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERD 2782
Score = 124 bits (311), Expect = 6e-28
Identities = 236/1238 (19%), Positives = 507/1238 (40%), Gaps = 208/1238 (16%)
Query: 72 VAQETDVRA---QIRLQFRDVNGELIAVQRSMVCTQKSKKTEF-----------KTLEGV 117
+ QE ++A Q+ +Q ++ + E I + +C K K E + L+
Sbjct: 1430 IEQEDLIKALHTQLEMQAKE-HDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAA 1488
Query: 118 ITRTKHGEKVSLS-SKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKF 176
+ K K + S + + R I L S A + + + ++ + L L+++
Sbjct: 1489 LISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEER 1548
Query: 177 DEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKAC-EIRDQITSKEAQLT 235
D++ I ++ Q+ + ++ L+ L + KEK EI +SK A+ T
Sbjct: 1549 DKL------ITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAEST 1602
Query: 236 S----SKEIVKSYE---NELDPLKNRLKEIEHNLSKI----MKLDNEIKALDSRKKQMEK 284
KE+ K YE + + N + I+H + + +L ++++ ++ KK+ EK
Sbjct: 1603 EWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEK 1662
Query: 285 -------DNSELEEKMEKVFQGTDEQLNDLYHNHQR----------TVREKERKLVDCH- 326
+ E++EKM K + +++ +L + R T +E L+ +
Sbjct: 1663 QLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNA 1722
Query: 327 ---RELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSL--------A 375
ELE++ E L+++ L+ E+ L + + I S +L
Sbjct: 1723 SMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQ 1782
Query: 376 TQLELDGFERGPFSERQIKNFHKLVR---ERQEGEAKTANQLMN-DFAEKETLKQ--KQI 429
T + +G + P + + R AK+AN ++ DF+ + + +QI
Sbjct: 1783 TNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQI 1842
Query: 430 DEIRDKKTGLGRIIELKSEI--------------LSKKQNELKNVKYEL-------QQLE 468
D+++++ GL + E +S K ELK ++ E+ QQ++
Sbjct: 1843 DQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQ 1902
Query: 469 GSSDRILELDQELIKAERELSK------AEKNSNVETLKMEVISLQNEKADLDRTLRKLD 522
R+ +L + + + +L + AE N ++ +V Q + L+ ++ L
Sbjct: 1903 EELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLK 1962
Query: 523 QEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHS 582
+ + +L + + L K+K + +IRK G + K+L++ L
Sbjct: 1963 KCVSELEE------EKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKE 2016
Query: 583 KSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDL 642
K +E+ Q + + +++++ E+ + E + E Q +D E
Sbjct: 2017 KQQEVKQLQKDCIRYQEKISALERTVKAL--EFVQTESQ--------------KDLEITK 2060
Query: 643 DRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQ 702
+ L + +E K +A LA F L D V + + ELQ ++
Sbjct: 2061 ENLAQAVEHRKKAQAELA-------SFKVLLDDTQSEAARVLADNLKLKKELQSNKESVK 2113
Query: 703 SKLRLAPDKL-----KSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNV 757
S+++ + L ++ E LK+K+ +++ L +R+ + L E+ I E++ L
Sbjct: 2114 SQMKQKDEDLERRLEQAEEKHLKEKKNMQEK---LDALRREKVHL-EETIGEIQVTLNKK 2169
Query: 758 NRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQ-AAKL 816
++++Q+L+ +++ T L S + +R E K ERK + +K
Sbjct: 2170 DKEVQQLQENLDSTVTQLAAFTKSMSSLQ------DDRDRVIDEAKKWERKFSDAIQSKE 2223
Query: 817 QGIDL--DRTVQQVNQEKQEKQH--KLDTVSSKIELNRKLIQDQ-QEQIQHLKSTTNELK 871
+ I L D +Q +Q H +L S++E ++++ + + Q ++Q + + L+
Sbjct: 2224 EEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQ 2283
Query: 872 SEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEK----- 926
E ++ + L+ + L + E+ L E+K K+Q++ L +LEK +++K
Sbjct: 2284 GENKELLSQLEETRHLYHSS---QNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEG 2340
Query: 927 ----------------EELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKD 970
E+L S ++ +I K + I + E IQ
Sbjct: 2341 IIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIA 2400
Query: 971 DYKKQKETELNKVIAQLSE--------CEKHKEKINEDMRLMR--QDIDTQKIQERWLQD 1020
+ ++Q + E+ ++ LS+ E++K+ +++ +LM + I + IQ++ D
Sbjct: 2401 ELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLD 2460
Query: 1021 NL-----TLRKRNEEL----KEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNH 1071
+ +L+ + + +++EE + E Q+ + + +E+ KL+E I ++ +
Sbjct: 2461 SFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQL-IQEAAAENNKLKEEIRGLRSHM 2519
Query: 1072 NLALGRQKGYEEEIIHFKKELRE-----------------PQFRDAEEKYREMMIVMRTT 1114
+ + E+I ++++L + Q ++ E KY ++ ++ +
Sbjct: 2520 DDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKES 2579
Query: 1115 ELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWR 1152
E N+DL + L + S ++E + I L R
Sbjct: 2580 EEANEDLRRSFNALQEEKQDL-SKEIESLKVSISQLTR 2616
Score = 122 bits (306), Expect = 2e-27
Identities = 215/1099 (19%), Positives = 457/1099 (41%), Gaps = 149/1099 (13%)
Query: 73 AQETDVRAQIRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTL--EGVITRTKHGE-KVSL 129
+ + V++Q++ + D+ L + + +K+ + + L E V GE +V+L
Sbjct: 2107 SNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTL 2166
Query: 130 SSKCAEIDR--EMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKF-DEIFSATRYI 186
+ K E+ + E + S A + Q+D + + E K ++KF D I S I
Sbjct: 2167 NKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEI 2226
Query: 187 KALETLRQVRQTQGQKVKEYQMELKYL------------------KQYKEKAC------- 221
+ E V + Q +++ + ELK Q ++K C
Sbjct: 2227 RLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGEN 2286
Query: 222 -EIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKK 280
E+ Q+ SS+ + E+EL LK++L ++ ++L K + ++ + R++
Sbjct: 2287 KELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGI-IRQQ 2345
Query: 281 QMEKDNSELE-EKMEKVFQGTDEQLNDLYHNHQRTVREKERKLV---------------D 324
+ + NS+ E++E Q + E + L+ + KE+K++ +
Sbjct: 2346 EADIQNSKFSYEQLETDLQASRELTSRLHEE----INMKEQKIISLLSGKEEAIQVAIAE 2401
Query: 325 CHRELEKLNKE-SRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLI-QSLATQLELDG 382
++ +K KE LL+QE+ E +V + + D+ + + ++ +++ + +LD
Sbjct: 2402 LRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDS 2461
Query: 383 FERGPFS-----ERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKT 437
F + S +R + ++ +L ER +QL+ + A + +++I +R
Sbjct: 2462 FVKSMSSLQNDRDRIVGDYQQL-EERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMD 2520
Query: 438 GLG-RIIELKSEILSKKQ--NELKNVK--YELQQLEGSSDRILELDQELIKAERELSKAE 492
L +L +E++ ++ N++ +K + Q LE + EL+ + K E +L ++E
Sbjct: 2521 DLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESE 2580
Query: 493 KNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKAD---KD 549
+ + E L+ +LQ EK DL + + L + QL T + L A K+
Sbjct: 2581 EAN--EDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKE 2638
Query: 550 EQIRKIKSRHSD-----------------ELTSLLGYFPNK--KQLEDWLHSKSKEINQT 590
E++ ++ + S E +G +K K+L+ H N+T
Sbjct: 2639 EEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNET 2698
Query: 591 R---DRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESD-LDRLK 646
+R+A+L ++L EQ + E K Q+ S+ + + S+D ++ LD LK
Sbjct: 2699 ETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELK 2758
Query: 647 EEIEKSSKQRAMLAGA-------TAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVIS 699
+ + S K+ A L A+ S+ + ++ +++ Q E +
Sbjct: 2759 RKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLL 2818
Query: 700 DLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRN---KLQN 756
L S+L + ++++S + + RD + + + + K++ + ++Q+
Sbjct: 2819 HLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQS 2878
Query: 757 VNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKL 816
+ + + L+ND ++ LL + ++ ++T + + +L++ + K +A ++
Sbjct: 2879 LKKAMSSLQND---RDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKT--KAFQI 2933
Query: 817 QGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRK--------LIQDQQEQIQHLKSTTN 868
+ ++Q N Q + H+L S E++ + I D+ +Q+ HL++
Sbjct: 2934 ----MQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIR 2989
Query: 869 ELKSEKLQ---ISTNLQRR------------QQLEEQTVELSTEVQSLYREIKDAKEQVS 913
EL+S Q + QR+ Q L +T L T++ +EI + ++
Sbjct: 2990 ELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQ 3049
Query: 914 PLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYK 973
L + + +EK L +L D + ++ + D+ N+ + +
Sbjct: 3050 QLNSNFSQLLEEKNTL-----------SIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQ 3098
Query: 974 KQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKE 1033
+ + LN +A + EK+ D +R+ Q E Q T ++ NE K
Sbjct: 3099 ELQAGPLNIDVAPGAPQEKNGVHRKSDPEELRE--PQQSFSEAQQQLCNTRQEVNELRKL 3156
Query: 1034 VEEERKQHLKEMGQMQVLQ 1052
+EEER Q + + V +
Sbjct: 3157 LEEERDQRVAAENALSVAE 3175
Score = 110 bits (276), Expect = 7e-24
Identities = 227/1098 (20%), Positives = 455/1098 (41%), Gaps = 180/1098 (16%)
Query: 71 KVAQETDVRAQIRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITRTKHGEKVSLS 130
+V +E D R + +++ + EL+ + TQ +TE + V+ R + SL
Sbjct: 217 QVVREKDARFETQVRLHE--DELL-----QLVTQADVETEMQQKLRVLQRKLEEHEESLV 269
Query: 131 SKCAEID----------------REMISSLGVSKAVLNNVIFCHQEDSNWPLS----EGK 170
+ +D + + + L N + +E+S L E
Sbjct: 270 GRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVA 329
Query: 171 ALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQ-MELKYLKQYKEKACEIRD-QIT 228
K F + ++ LE Q Q Q + Y +E K+ + +EK I Q T
Sbjct: 330 ERKLSFHNLQEEMHHL--LEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKT 387
Query: 229 SKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSE 288
+E Q S+ + +K ++L L+++ ++ + I +L+++++ Q K+ S+
Sbjct: 388 GQELQ--SACDALKDQNSKL--LQDKNEQAVQSAQTIQQLEDQLQ-------QKSKEISQ 436
Query: 289 LEEKMEKVFQGTDEQLN--DLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSEL 346
++ T Q + D+Y+ + V E+ + L K L EK L
Sbjct: 437 FLNRLPLQQHETASQTSFPDVYNEGTQAVTEEN---------IASLQKRVVELENEKGAL 487
Query: 347 LVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKL-VRERQE 405
L+ L E ++A + + S T LE R ++R++ + + ++
Sbjct: 488 LLSSIEL--------EELKAENEKLSSQITLLEAQN--RTGEADREVSEISIVDIANKRS 537
Query: 406 GEAKTANQ--LMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYE 463
A+ + Q L N F++K K++ + ++E+K + Q E+ +K +
Sbjct: 538 SSAEESGQDVLENTFSQKH----KELSVL---------LLEMK-----EAQEEIAFLKLQ 579
Query: 464 LQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADL------DRT 517
LQ R E D E++ ++E+ + E + +KM+V L++ D + +
Sbjct: 580 LQ-----GKRAEEADHEVLD-QKEMKQME-GEGIAPIKMKVF-LEDTGQDFPLMPNEESS 631
Query: 518 LRKLDQEMEQLNHHTTTRTQMEM--------LTKDKADKD-EQIRKIKSRHSDELTSL-- 566
L +++E H + T ++ + TK DK + I H DEL L
Sbjct: 632 LPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKS 691
Query: 567 ------LGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEE 620
L + ++ E L K+KEI+ L +L +E + N + L + +
Sbjct: 692 QILELELNFHKAQEIYEKNLDEKAKEISN----LNQLIEEFKKNADNNSSAFTALSEERD 747
Query: 621 QLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQ----LTDE 676
QL S +L V + + + +L+ + ++ +QR + + + +T+ L+ E
Sbjct: 748 QLLSQVKELSMVT---ELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIE 804
Query: 677 NQSCCPVCQRVFQTEAE-LQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPM 735
+S V V Q E + +Q S+ + +R +L++ ESE+ + +R + V
Sbjct: 805 AKSK-DVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEE 863
Query: 736 RQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIM 795
+ KE EI ++ L RD++ L+ IEE++ + I V L +
Sbjct: 864 LSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNE---- 919
Query: 796 ERFQM--ELKDVERKI----AQQAAKLQGIDLDRTVQQVNQE------------KQEKQH 837
E+F + E+K ++ ++ + AK + ++ D V ++ K+E QH
Sbjct: 920 EKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQH 979
Query: 838 KLDTVSSKIELNRKLIQ----DQQEQIQHLKSTTNELKS----EKLQISTNLQRRQQLEE 889
+ D + + E ++ +Q +++E +Q + EL + K +I + R ++EE
Sbjct: 980 EFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEE 1039
Query: 890 --QTVELSTE-VQSLYREIK-DAKEQVSPLETTLEKFQQEKEELINKK-------NTSNK 938
+ E S + V S +EI+ K+ +S E L+ +++ EE + + N+
Sbjct: 1040 DKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQ 1099
Query: 939 IAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKE--K 996
QDK N I I I+ I D + + + C E K
Sbjct: 1100 TLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWK 1159
Query: 997 INEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSE 1056
+ +++ + + +++Q++ LQ+ LT RK + + +E+++HL+E ++ Q K +
Sbjct: 1160 PELEEKILALEKEKEQLQKK-LQEALTSRK---AILKKAQEKERHLRE----ELKQQKDD 1211
Query: 1057 HQKLEENID-NIKRNHNL 1073
+ +L+E D K N N+
Sbjct: 1212 YNRLQEQFDEQSKENENI 1229
Score = 107 bits (268), Expect = 6e-23
Identities = 214/1183 (18%), Positives = 495/1183 (41%), Gaps = 152/1183 (12%)
Query: 74 QETDVRAQIRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITRTKHGEKVSLSSKC 133
+E + ++R Q + + L +R +S+ + ++T H + SK
Sbjct: 754 KELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAH----DNLLTEQIHSLSIEAKSKD 809
Query: 134 AEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALET-L 192
+I+ V + L++V E S S L+ K E+ ++ + + +
Sbjct: 810 VKIE--------VLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKV 861
Query: 193 RQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLT----SSKEIVKSYENEL 248
++ Q QK E + L + K ++ I K+ Q+T S E + E
Sbjct: 862 EELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEK 921
Query: 249 DPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDN---SELEEKMEKVFQGTDEQLN 305
L +K ++ L+ + + + +++K+Q+E+DN S L++ +++
Sbjct: 922 FSLGVEIKTLKEQLNLLSRAE------EAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKE 975
Query: 306 DLYHNHQRTVREKERK-------LVDCHRELEKLNK-ESRLLN---QEKSEL-LVEQGRL 353
+L H +E E++ L++ L+++++ E L N + K E+ L E R
Sbjct: 976 ELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERG 1035
Query: 354 QLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFH-------KLVRERQ-E 405
+++ D+ E+ + + S ++E+ + + SE++++ H KL E Q +
Sbjct: 1036 EVEEDK--ENKEYSEKCVTSKCQEIEI--YLKQTISEKEVELQHIRKDLEEKLAAEEQFQ 1091
Query: 406 GEAKTANQLMND-----------FAEKETLKQKQIDEIRDKKTGLGRII----------- 443
K NQ + D +E + + QK I D G +
Sbjct: 1092 ALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPC 1151
Query: 444 ---------ELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKN 494
EL+ +IL+ ++ E + ++ +LQ+ S IL+ QE + RE K +K+
Sbjct: 1152 TGSSEHWKPELEEKILALEK-EKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKD 1210
Query: 495 SNVETLKMEVISLQNEKADLDRTLRKLD-QEMEQLNHHTTTRTQMEMLTKD--------K 545
+ L+ + E ++ LR+L Q E ++ + Q E + K
Sbjct: 1211 -DYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFK 1269
Query: 546 ADKDEQIRKIKSR--------HSDELTSLLG-------------YFPNKKQLE------- 577
A + + + HS++ ++L G K +LE
Sbjct: 1270 ATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTT 1329
Query: 578 DWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQD 637
L KS+E+ Q ++++ K E+ S + + + +++L S + ++ + ++
Sbjct: 1330 SELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRE 1389
Query: 638 FESDLDRLKEEIEKSSKQRAMLAGAT----AVYSQFITQLTDENQSCCPVCQRVFQTEAE 693
+ LD L++ I K + + L+G A ++ T++ ++ + ++ E
Sbjct: 1390 LQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKE 1449
Query: 694 LQEVISDLQSKLRLAPDKLKSTESELKKKEK-RRDEMLGLVPMRQSIIDLK--EKEIPEL 750
E I LQ +L K + E + K++ +R L+ ++++ + K ++E+
Sbjct: 1450 HDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLA 1509
Query: 751 RNKLQNVNRDIQRLKNDI----EEQETLLGTI-MPEEESAKVCLTDVTIMERFQMELKDV 805
R ++ + + + +++ + +E++T+LG + + +EE K+ +T M+R +E + +
Sbjct: 1510 RGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKL----ITEMDRSLLENQSL 1565
Query: 806 ERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKS 865
L+G+ D+ + V + + K K+ + E +++L ++ + +Q ++
Sbjct: 1566 SSSCESLKLALEGLTEDKE-KLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYEN 1624
Query: 866 TTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQE 925
+NE + + + Q +Q+L + + +++++A++++ ++ + KF +
Sbjct: 1625 VSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKS 1684
Query: 926 KEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIA 985
K++ I + N + +++ + K + +++ + K + ET K +
Sbjct: 1685 KQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQS 1744
Query: 986 QLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEM 1045
+SE K+ ++E+++ ++ I+ + Q NL ++++ V EE Q +
Sbjct: 1745 LMSE----KDSLSEEVQDLKHQIEGNVSK----QANLEATEKHDNQTNVTEEGTQSIPGE 1796
Query: 1046 GQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDA--EEK 1103
+ Q S E++ + K + N A+ + +EI ++ +++ + + R A EE+
Sbjct: 1797 TEEQDSLSMSTRPTCSESVPSAK-SANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEE 1855
Query: 1104 YREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKI 1146
++ +T E L T D + M EE+ K+
Sbjct: 1856 KQKNKEFSQTLENEKNTLLSQISTKDGEL----KMLQEEVTKM 1894
Score = 102 bits (254), Expect = 2e-21
Identities = 222/1081 (20%), Positives = 438/1081 (40%), Gaps = 183/1081 (16%)
Query: 191 TLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDP 250
T Q R ++ + + +ELK KQ +K+ L++ +I + +++EL+
Sbjct: 642 TEHQSRTSEEISLNDAGVELKSTKQDGDKS-------------LSAVPDIGQCHQDELER 688
Query: 251 LKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEE------KMEKVFQGTDEQL 304
LK+++ E+E N K ++ K LD + K++ N +EE F E+
Sbjct: 689 LKSQILELELNFHKAQEIYE--KNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEER 746
Query: 305 NDLYHNHQRT---------VREKERKLVDCHRELEKLNKESR-----LLNQEKSELLVEQ 350
+ L + V++ E L + R+ +L+ ES+ LL ++ L +E
Sbjct: 747 DQLLSQVKELSMVTELRAQVKQLEMNLAEAERQ-RRLDYESQTAHDNLLTEQIHSLSIEA 805
Query: 351 GR-------LQLQADRHQEHIRARDSLIQSLATQLE------LDGFERGPFSERQIKNFH 397
LQ + D Q + +LI+SL +QL+ L+G ER +++
Sbjct: 806 KSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELS 865
Query: 398 KLVRERQEGEAKTANQLMNDFAEKETLKQ------KQIDEIRDKKTGLGRIIELKSEILS 451
+ + +++ K L+ + ETL+Q +Q+ EI T ++++L E S
Sbjct: 866 QALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTE--KMVQLNEEKFS 923
Query: 452 KKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEK 511
E+K +K +L L R E +E ++ + E+S K + E IS + +
Sbjct: 924 LGV-EIKTLKEQLNLLS----RAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQ 978
Query: 512 ADLDRTLRKLDQEMEQLNHHTTTRTQM----EMLTKDKADKDEQIRKIKSRHSDELTSLL 567
+ D ++ +Q +L R ++ L ++ A+ ++ +K E +
Sbjct: 979 HEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVE 1038
Query: 568 GYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRK---EEQLSS 624
NK+ E + SK +EI L + ++ E HI +L+ K EEQ +
Sbjct: 1039 EDKENKEYSEKCVTSKCQEIE------IYLKQTISEKEVELQHIRKDLEEKLAAEEQFQA 1092
Query: 625 YEDKLFDVCGSQDFESDLDRLKEEI-EKSSKQRAMLAGATAVYSQFITQLTDENQSCCPV 683
++ QD + +D L+ EI E + + ++ T L E P
Sbjct: 1093 LVKQMNQTL--QDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPP 1150
Query: 684 CQRVFQT-EAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDL 742
C + + EL+E I L+ K+KE+ + ++ + R++I+
Sbjct: 1151 CTGSSEHWKPELEEKILALE-----------------KEKEQLQKKLQEALTSRKAILKK 1193
Query: 743 KEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMEL 802
+++ LR +L+ D RL+ +EQ E E+ L + I R ++
Sbjct: 1194 AQEKERHLREELKQQKDDYNRLQEQFDEQSK-------ENENIGDQLRQLQIQVRESIDG 1246
Query: 803 KDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQD---QQEQ 859
K + + G++ K +QH V L L D E
Sbjct: 1247 KLPSTDQQESCSSTPGLEEPLF-------KATEQHHTQPV-----LESNLCPDWPSHSED 1294
Query: 860 IQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTL 919
L+ T+ QI L+ ++E + VEL +V S E+ E+V L+ +
Sbjct: 1295 ASALQGGTSVA-----QIKAQLK---EIEAEKVELELKVSSTTSELTKKSEEVFQLQEQI 1346
Query: 920 EKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENY--IQDGKDDYKK--- 974
K E E L T + A+ +++K+++ + +E+ +Q D+ +K
Sbjct: 1347 NKQGLEIESL----KTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLIS 1402
Query: 975 QKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEV 1034
+KE +++ + QLSE E KI ++ + ++D+ I+ Q + ++ +E +K++
Sbjct: 1403 KKEEDVSYLSGQLSEKEAALTKIQTEI-IEQEDL----IKALHTQLEMQAKEHDERIKQL 1457
Query: 1035 EE---ERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEE------- 1084
+ E KQ +E+G + Q+++ + + AL K +EE
Sbjct: 1458 QVELCEMKQKPEEIG-----EESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGT 1512
Query: 1085 IIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMK----- 1139
I K L + + + + + +E V+ L+ ++ D +D+++++ S+
Sbjct: 1513 IERLTKSLADVESQVSAQN-KEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCES 1571
Query: 1140 --------MEEINKIIRDL-------------WRSTYRGQDIEYIEIRSDADENVSASDK 1178
E+ K+++++ W+ ++ EY EI + ENVS +
Sbjct: 1572 LKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEY-EILLQSYENVSNEAE 1630
Query: 1179 R 1179
R
Sbjct: 1631 R 1631
Score = 88.2 bits (217), Expect = 5e-17
Identities = 133/638 (20%), Positives = 266/638 (41%), Gaps = 100/638 (15%)
Query: 464 LQQLEGSSDRILELDQELIKAERELSKAE-KNSNVETLKMEVISLQNEKADLDRTLRKLD 522
L +L G D + L + S E N+ E ++ + + +L +R+ D
Sbjct: 13 LHELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKD 72
Query: 523 QEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHS 582
+++Q + E L +++ D +I+K+K +LTSL Y K +
Sbjct: 73 VQLQQKD---------EALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLP 123
Query: 583 KSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDL 642
Q+ ++L+K +K E I ++L+ KEE +S+ + +L Q +S
Sbjct: 124 TEP---QSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSST 180
Query: 643 D---------RLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTE-- 691
+ +L+E+ E S +A L+ A Q Q+ E + R+ + E
Sbjct: 181 EMEEFVMMKQQLQEKEEFISTLQAQLSQTQA--EQAAQQVVREKDARFETQVRLHEDELL 238
Query: 692 --AELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPE 749
+V +++Q KLR+ KL E+ + ++G R ++DL ++E+
Sbjct: 239 QLVTQADVETEMQQKLRVLQRKL----------EEHEESLVG----RAQVVDLLQQELTA 284
Query: 750 LRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKI 809
+ Q +++ +Q+++ E TL T+ E E +K+ L +MEL+ ERK+
Sbjct: 285 AEQRNQILSQQLQQME---AEHNTLRNTVETEREESKILLE--------KMELEVAERKL 333
Query: 810 A---------------QQAAKLQGIDLDRTVQQVNQ----EKQEK-QHKLDTVSSKIEL- 848
+ +QA + Q +L+ + Q E +EK H L + EL
Sbjct: 334 SFHNLQEEMHHLLEQFEQAGQAQA-ELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQ 392
Query: 849 ---------NRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQR---RQQLEEQTVELST 896
N KL+QD+ EQ T +L+ + Q S + + R L++ T
Sbjct: 393 SACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQT 452
Query: 897 EVQSLYREIKDA--KEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNI 954
+Y E A +E ++ L+ + + + EK L+ ++ +L ++K + + +
Sbjct: 453 SFPDVYNEGTQAVTEENIASLQKRVVELENEKGALL--------LSSIELEELKAENEKL 504
Query: 955 HGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINED-MRLMRQDIDTQKI 1013
+ +E + G+ D + + + ++ + S E+ + + E+ +++ +
Sbjct: 505 SSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLL 564
Query: 1014 QERWLQDNLTLRKRNEELKEVEEERKQHL--KEMGQMQ 1049
+ + Q+ + K + K EE + L KEM QM+
Sbjct: 565 EMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQME 602
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 143 bits (360), Expect = 1e-33
Identities = 212/1057 (20%), Positives = 459/1057 (43%), Gaps = 163/1057 (15%)
Query: 185 YIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSY 244
+ K L+ RQ + + KE EL+ K+ ++KA ++ K +QLT K +++
Sbjct: 838 FTKVKPLLQVTRQEEEMQAKED--ELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895
Query: 245 ---ENE-----------LDPLKNRLKEIEHNL-SKIMKLDNEIKALDSRKKQMEKDNSEL 289
E E L K L+EI H + +++ + ++ + L + +K+M + +L
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 290 EEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVE 349
EE++E+ + ++L + +++ E +++ + KL+KE +LL + S+L
Sbjct: 956 EEQLEEE-EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014
Query: 350 QGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAK 409
+ +A + +S+I L +L+ + E+ + KL R + EG+A
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKE--------EKSRQELEKLKR-KLEGDA- 1064
Query: 410 TANQLMNDFAEKETLKQKQIDEIR----DKKTGLGRIIELKSEILSKKQNELKNVKYELQ 465
+DF E+ Q QI E++ K+ L + + +++K N LK ++
Sbjct: 1065 ------SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR---- 1114
Query: 466 QLEGS-SDRILELDQE-LIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQ 523
+LEG SD +LD E + + E K + +E LK E+ + A K +Q
Sbjct: 1115 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ 1174
Query: 524 EMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSK 583
E+ L + L ++ + Q+++++ +H+ + L +QLE + +K
Sbjct: 1175 EVTVLK---------KALDEETRSHEAQVQEMRQKHAQAVEEL------TEQLEQFKRAK 1219
Query: 584 SKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLD 643
+ +++ + L K N +LA + E++ K+++L + +L C SD +
Sbjct: 1220 A-NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC------SDGE 1272
Query: 644 RLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQS 703
R + E+ + +L +E +S + +L + ++ L S
Sbjct: 1273 RARAELNDK-----------------VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315
Query: 704 KLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQR 763
+L+ D + + E ++K ++ L R S+ D ++E+ +N ++++ +
Sbjct: 1316 QLQ---DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 764 LKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDR 823
L + ++ + T+ EE K RFQ E++++ ++ ++AA
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKK----------RFQKEIENLTQQYEEKAA--------- 1413
Query: 824 TVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTN-LQ 882
++ + K Q +LD + ++ R+L+ + +++ + ++L +E+ IS+
Sbjct: 1414 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK----QRKFDQLLAEEKNISSKYAD 1469
Query: 883 RRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQD 942
R + E + E T+ SL R +++A E LE T + + E E+L++ K+
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD-------- 1521
Query: 943 KLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMR 1002
+ KN+H K K+ ET++ ++ QL E E + ED +
Sbjct: 1522 ------DVGKNVHELEKS------------KRALETQMEEMKTQLEELEDELQ-ATEDAK 1562
Query: 1003 LMRQDIDTQKIQERWLQDNLTLRKRNEELK------------EVEEERKQHLKEMGQMQV 1050
L R +++ Q ++ ++ +D ++NEE + E+E+ERKQ + +
Sbjct: 1563 L-RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ--RALAAAAK 1619
Query: 1051 LQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKEL------REPQFRDAEEKY 1104
+++ + + LE D+ + A+ + + + ++ F++EL R+ F A+E
Sbjct: 1620 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1679
Query: 1105 REMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKII-RDLWRSTYRGQDIEYI 1163
++ + + +DL + QA ++ + E + + R+ + R +
Sbjct: 1680 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739
Query: 1164 EIRSDADE---NVSA-SDKRRNYNYRVVMLKGDTALD 1196
++ + +E N+ A SD+ R + L + A +
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1776
Score = 120 bits (301), Expect = 9e-27
Identities = 211/981 (21%), Positives = 406/981 (41%), Gaps = 157/981 (16%)
Query: 74 QETDVRAQI---RLQFRDVNGELIAVQRSM---VCTQKSKKTEFKTLEGVITRTKHG--E 125
Q D++AQI ++Q EL A + + + + + + LEG I+ +
Sbjct: 1070 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1129
Query: 126 KVSLSSKCAEIDREMISSLGVSKAVLNNVI---FCHQEDSNWPLSEGKALKQKFDEIFSA 182
+ + +K + R++ L K L + + QE E LK+ DE
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE---E 1186
Query: 183 TRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVK 242
TR +A ++++RQ Q V+E +L+ K+ K + + + + A L
Sbjct: 1187 TRSHEA--QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG------ 1238
Query: 243 SYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDE 302
EL L +E+EH K KL+ +++ L S+ E+ +EL +K+ K+ Q E
Sbjct: 1239 ----ELRVLGQAKQEVEH---KKKKLEAQVQELQSKCSDGERARAELNDKVHKL-QNEVE 1290
Query: 303 QLNDLYHNHQ-------RTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQL 355
+ + + + + V +L D L++ ++ ++ + +L E+ LQ
Sbjct: 1291 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1350
Query: 356 QADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLM 415
Q D E + + I +L QL S++++++F V +EG+ + ++
Sbjct: 1351 QLDEEMEAKQNLERHISTLNIQLS--------DSKKKLQDFASTVEALEEGKKRFQKEIE 1402
Query: 416 N---DFAEK-------ETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQ 465
N + EK E K + E+ D L +L S L KKQ + + E +
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN-LEKKQRKFDQLLAEEK 1461
Query: 466 QLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEM 525
+ + E +AE E EK + +L + K +L+RT + L EM
Sbjct: 1462 NISS------KYADERDRAEAEAR--EKETKALSLARALEEALEAKEELERTNKMLKAEM 1513
Query: 526 EQL-NHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKS 584
E L + + L K K + Q+ ++K++ ++LED
Sbjct: 1514 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ--------------LEELED------ 1553
Query: 585 KEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDR 644
E+ T D AKL E+ + + K +L+ ++EQ E+K + + L
Sbjct: 1554 -ELQATED--AKLRLEV-NMQALKGQFERDLQARDEQ---NEEK------RRQLQRQLHE 1600
Query: 645 LKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSK 704
+ E+E KQRA+ A A + L + S + + +LQ + D Q +
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660
Query: 705 L---RLAPDKLKSTESELKKKEKRRD-------EMLGLVPMRQSIIDLKEKEIPEL---- 750
L R + D++ +T E +KK K + E L + DL+++E+ E
Sbjct: 1661 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1720
Query: 751 ---RNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVER 807
RN LQ+ R ++ +EE+ + EE+ ++D + + + + +
Sbjct: 1721 LSGRNALQDEKRRLEARIAQLEEE-------LEEEQGNMEAMSDR--VRKATQQAEQLSN 1771
Query: 808 KIAQQAAKLQGIDLDRT-VQQVNQEKQEKQHKLD-TVSSKIE-----LNRKLIQ------ 854
++A + + Q + R +++ N+E + K H+++ V SK + L K+ Q
Sbjct: 1772 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1831
Query: 855 ----DQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKE 910
++Q + LK +LK LQ+ + +Q +EQ + + V+ L R++++A+E
Sbjct: 1832 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1891
Query: 911 QVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIH----------GYMKD 960
+ + K Q+E +E SN+ ++N +K K++ + G +
Sbjct: 1892 ESQRINANRRKLQRELDE----ATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRV 1947
Query: 961 IENYIQDGKDDYKKQKETELN 981
IEN DG ++ ++ + N
Sbjct: 1948 IEN--ADGSEEETDTRDADFN 1966
Score = 51.2 bits (121), Expect = 6e-06
Identities = 64/361 (17%), Positives = 151/361 (41%), Gaps = 28/361 (7%)
Query: 856 QQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPL 915
Q+E++Q + + K + + L+ +Q Q E +Q + + + +
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909
Query: 916 ETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQ 975
L +QE EE++++ + +D+ ++ + K + M D+E +++ ++ +Q
Sbjct: 910 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQ 967
Query: 976 KETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVE 1035
K +L KV A+ + E + D + + + + ++ER L + E+ K +
Sbjct: 968 K-LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 1036 EERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREP 1095
+ + +H + +++V K E K + ++ +KR G + E+I + ++ E
Sbjct: 1027 KLKNKHESMISELEVRLKKEE--KSRQELEKLKRKLE---GDASDFHEQIADLQAQIAEL 1081
Query: 1096 QFRDAEEKYREMMIVMRTTELVN---------KDLDIYYKTLDQAIMKFHSMKMEEINKI 1146
+ + A+++ + R + + ++L+ + L + + + + + K
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR-NKAEKQ 1140
Query: 1147 IRDLWRSTYRGQDIEYI--EIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAG 1204
RDL G+++E + E+ D + + R V +LK ALD R
Sbjct: 1141 KRDL------GEELEALKTELEDTLDSTATQQELRAKREQEVTVLK--KALDEETRSHEA 1192
Query: 1205 Q 1205
Q
Sbjct: 1193 Q 1193
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 143 bits (360), Expect = 1e-33
Identities = 212/1057 (20%), Positives = 459/1057 (43%), Gaps = 163/1057 (15%)
Query: 185 YIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSY 244
+ K L+ RQ + + KE EL+ K+ ++KA ++ K +QLT K +++
Sbjct: 845 FTKVKPLLQVTRQEEEMQAKED--ELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 245 ---ENE-----------LDPLKNRLKEIEHNL-SKIMKLDNEIKALDSRKKQMEKDNSEL 289
E E L K L+EI H + +++ + ++ + L + +K+M + +L
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 290 EEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVE 349
EE++E+ + ++L + +++ E +++ + KL+KE +LL + S+L
Sbjct: 963 EEQLEEE-EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021
Query: 350 QGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAK 409
+ +A + +S+I L +L+ + E+ + KL R + EG+A
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKE--------EKSRQELEKLKR-KLEGDA- 1071
Query: 410 TANQLMNDFAEKETLKQKQIDEIR----DKKTGLGRIIELKSEILSKKQNELKNVKYELQ 465
+DF E+ Q QI E++ K+ L + + +++K N LK ++
Sbjct: 1072 ------SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR---- 1121
Query: 466 QLEGS-SDRILELDQE-LIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQ 523
+LEG SD +LD E + + E K + +E LK E+ + A K +Q
Sbjct: 1122 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ 1181
Query: 524 EMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSK 583
E+ L + L ++ + Q+++++ +H+ + L +QLE + +K
Sbjct: 1182 EVTVLK---------KALDEETRSHEAQVQEMRQKHAQAVEEL------TEQLEQFKRAK 1226
Query: 584 SKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLD 643
+ +++ + L K N +LA + E++ K+++L + +L C SD +
Sbjct: 1227 A-NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC------SDGE 1279
Query: 644 RLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQS 703
R + E+ + +L +E +S + +L + ++ L S
Sbjct: 1280 RARAELNDK-----------------VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322
Query: 704 KLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQR 763
+L+ D + + E ++K ++ L R S+ D ++E+ +N ++++ +
Sbjct: 1323 QLQ---DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 764 LKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDR 823
L + ++ + T+ EE K RFQ E++++ ++ ++AA
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKK----------RFQKEIENLTQQYEEKAA--------- 1420
Query: 824 TVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTN-LQ 882
++ + K Q +LD + ++ R+L+ + +++ + ++L +E+ IS+
Sbjct: 1421 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK----QRKFDQLLAEEKNISSKYAD 1476
Query: 883 RRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQD 942
R + E + E T+ SL R +++A E LE T + + E E+L++ K+
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD-------- 1528
Query: 943 KLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMR 1002
+ KN+H K K+ ET++ ++ QL E E + ED +
Sbjct: 1529 ------DVGKNVHELEKS------------KRALETQMEEMKTQLEELEDELQ-ATEDAK 1569
Query: 1003 LMRQDIDTQKIQERWLQDNLTLRKRNEELK------------EVEEERKQHLKEMGQMQV 1050
L R +++ Q ++ ++ +D ++NEE + E+E+ERKQ + +
Sbjct: 1570 L-RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ--RALAAAAK 1626
Query: 1051 LQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKEL------REPQFRDAEEKY 1104
+++ + + LE D+ + A+ + + + ++ F++EL R+ F A+E
Sbjct: 1627 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1686
Query: 1105 REMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKII-RDLWRSTYRGQDIEYI 1163
++ + + +DL + QA ++ + E + + R+ + R +
Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746
Query: 1164 EIRSDADE---NVSA-SDKRRNYNYRVVMLKGDTALD 1196
++ + +E N+ A SD+ R + L + A +
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1783
Score = 120 bits (301), Expect = 9e-27
Identities = 211/981 (21%), Positives = 406/981 (41%), Gaps = 157/981 (16%)
Query: 74 QETDVRAQI---RLQFRDVNGELIAVQRSM---VCTQKSKKTEFKTLEGVITRTKHG--E 125
Q D++AQI ++Q EL A + + + + + + LEG I+ +
Sbjct: 1077 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1136
Query: 126 KVSLSSKCAEIDREMISSLGVSKAVLNNVI---FCHQEDSNWPLSEGKALKQKFDEIFSA 182
+ + +K + R++ L K L + + QE E LK+ DE
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE---E 1193
Query: 183 TRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVK 242
TR +A ++++RQ Q V+E +L+ K+ K + + + + A L
Sbjct: 1194 TRSHEA--QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG------ 1245
Query: 243 SYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDE 302
EL L +E+EH K KL+ +++ L S+ E+ +EL +K+ K+ Q E
Sbjct: 1246 ----ELRVLGQAKQEVEH---KKKKLEAQVQELQSKCSDGERARAELNDKVHKL-QNEVE 1297
Query: 303 QLNDLYHNHQ-------RTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQL 355
+ + + + + V +L D L++ ++ ++ + +L E+ LQ
Sbjct: 1298 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1357
Query: 356 QADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLM 415
Q D E + + I +L QL S++++++F V +EG+ + ++
Sbjct: 1358 QLDEEMEAKQNLERHISTLNIQLS--------DSKKKLQDFASTVEALEEGKKRFQKEIE 1409
Query: 416 N---DFAEK-------ETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQ 465
N + EK E K + E+ D L +L S L KKQ + + E +
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN-LEKKQRKFDQLLAEEK 1468
Query: 466 QLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEM 525
+ + E +AE E EK + +L + K +L+RT + L EM
Sbjct: 1469 NISS------KYADERDRAEAEAR--EKETKALSLARALEEALEAKEELERTNKMLKAEM 1520
Query: 526 EQL-NHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKS 584
E L + + L K K + Q+ ++K++ ++LED
Sbjct: 1521 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ--------------LEELED------ 1560
Query: 585 KEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDR 644
E+ T D AKL E+ + + K +L+ ++EQ E+K + + L
Sbjct: 1561 -ELQATED--AKLRLEV-NMQALKGQFERDLQARDEQ---NEEK------RRQLQRQLHE 1607
Query: 645 LKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSK 704
+ E+E KQRA+ A A + L + S + + +LQ + D Q +
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667
Query: 705 L---RLAPDKLKSTESELKKKEKRRD-------EMLGLVPMRQSIIDLKEKEIPEL---- 750
L R + D++ +T E +KK K + E L + DL+++E+ E
Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1727
Query: 751 ---RNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVER 807
RN LQ+ R ++ +EE+ + EE+ ++D + + + + +
Sbjct: 1728 LSGRNALQDEKRRLEARIAQLEEE-------LEEEQGNMEAMSDR--VRKATQQAEQLSN 1778
Query: 808 KIAQQAAKLQGIDLDRT-VQQVNQEKQEKQHKLD-TVSSKIE-----LNRKLIQ------ 854
++A + + Q + R +++ N+E + K H+++ V SK + L K+ Q
Sbjct: 1779 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1838
Query: 855 ----DQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKE 910
++Q + LK +LK LQ+ + +Q +EQ + + V+ L R++++A+E
Sbjct: 1839 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1898
Query: 911 QVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIH----------GYMKD 960
+ + K Q+E +E SN+ ++N +K K++ + G +
Sbjct: 1899 ESQRINANRRKLQRELDE----ATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRV 1954
Query: 961 IENYIQDGKDDYKKQKETELN 981
IEN DG ++ ++ + N
Sbjct: 1955 IEN--ADGSEEETDTRDADFN 1973
Score = 51.2 bits (121), Expect = 6e-06
Identities = 64/361 (17%), Positives = 151/361 (41%), Gaps = 28/361 (7%)
Query: 856 QQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPL 915
Q+E++Q + + K + + L+ +Q Q E +Q + + + +
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916
Query: 916 ETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQ 975
L +QE EE++++ + +D+ ++ + K + M D+E +++ ++ +Q
Sbjct: 917 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQ 974
Query: 976 KETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVE 1035
K +L KV A+ + E + D + + + + ++ER L + E+ K +
Sbjct: 975 K-LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 1036 EERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREP 1095
+ + +H + +++V K E K + ++ +KR G + E+I + ++ E
Sbjct: 1034 KLKNKHESMISELEVRLKKEE--KSRQELEKLKRKLE---GDASDFHEQIADLQAQIAEL 1088
Query: 1096 QFRDAEEKYREMMIVMRTTELVN---------KDLDIYYKTLDQAIMKFHSMKMEEINKI 1146
+ + A+++ + R + + ++L+ + L + + + + + K
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR-NKAEKQ 1147
Query: 1147 IRDLWRSTYRGQDIEYI--EIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAG 1204
RDL G+++E + E+ D + + R V +LK ALD R
Sbjct: 1148 KRDL------GEELEALKTELEDTLDSTATQQELRAKREQEVTVLK--KALDEETRSHEA 1199
Query: 1205 Q 1205
Q
Sbjct: 1200 Q 1200
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 138 bits (348), Expect = 3e-32
Identities = 226/1083 (20%), Positives = 463/1083 (42%), Gaps = 136/1083 (12%)
Query: 139 EMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQT 198
++ISS + N V E +W + Q D + K +++++Q
Sbjct: 166 DIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNS-DQSEICKLQNIIKELKQN 224
Query: 199 QGQKVKEYQMELKYLKQ-YKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKE 257
+ Q++ ++Q E+ L+ +++K EI + +E + YE ++ L+N L++
Sbjct: 225 RSQEIDDHQHEMSVLQNAHQQKLTEISRR----------HREELSDYEERIEELENLLQQ 274
Query: 258 -----IEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQ 312
IE +LSKI ++ I+ L K + K +LE+K++ + N +
Sbjct: 275 GGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDI-------------NKK 321
Query: 313 RTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQ 372
+ E +R ++ RE E+LN E R + +E L +E +LQ A + + + ++ ++
Sbjct: 322 LSSAENDRDIL--RREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILA 379
Query: 373 SLATQLELDGFERG-PFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDE 431
A+ E+ ++ +E +I L ++ N AE + LK K E
Sbjct: 380 QSASVEEVFRLQQALSDAENEIMRLSSLNQD-------------NSLAE-DNLKLKMRIE 425
Query: 432 IRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQEL--IKAERELS 489
+ +K+ L + + K E+ Q L + E + ++ ++ R + LD EL ++ E
Sbjct: 426 VLEKEKSL--LSQEKEEL----QMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAK 479
Query: 490 KAEKNSNV---ETL--KMEVISLQNEKADLDRTLRKLDQEMEQLNHHTT----------- 533
+ E N ++ ETL ++E + QN++A L K DQ +Q N +
Sbjct: 480 EQELNQSISEKETLIAEIEELDRQNQEATKHMILIK-DQLSKQQNEGDSIISKLKQDLND 538
Query: 534 TRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDR 593
+ ++ L DK D +++ K + +L K++LED + + ++N++++
Sbjct: 539 EKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQES 598
Query: 594 LAKLNKE-------LASSEQNKNHINNELKR--KEEQLSSYEDKLF-----DVCGSQDFE 639
+ KE + +E+ + I NEL + ++ S+++D L +V +
Sbjct: 599 NVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNL 658
Query: 640 SDLDRLKEEIEK-----SSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAEL 694
S+L++L E ++K + ++ V Q L NQ V + E
Sbjct: 659 SELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEK 718
Query: 695 QEVISDL-QSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNK 753
E+ ++L +K RL E K EK +E+ + S + L+ + + +L K
Sbjct: 719 GEIEAELCWAKKRLL--------EEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQK 770
Query: 754 ----LQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKI 809
+ + ++I+++ D +E + +L + + E++ LT + + +E K+
Sbjct: 771 KDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQ----LTQLINKKEIFIE------KL 820
Query: 810 AQQAAKLQGIDLDRTVQQVNQE---KQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKST 866
++++KLQ +LD+ Q + + +Q + K ++ S E N L Q++ E+++ +S
Sbjct: 821 KERSSKLQE-ELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHL-QEELERLREEQSR 878
Query: 867 TNELKSEK-LQISTNLQRR-QQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQ 924
T + K L T L QL L E++ + I+D + L +L++ ++
Sbjct: 879 TAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKK 938
Query: 925 EKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVI 984
E +E + N + E++K++ ++ I+ + + + D + +
Sbjct: 939 EMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETK 998
Query: 985 AQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKE 1044
Q E EK D+ + + I+ER L+ L K K++++ K E
Sbjct: 999 VQSLNIENGSEK--HDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKD---E 1053
Query: 1045 MGQM-QVLQMKS-EHQKLEENIDNIKRNHNLALGRQK----GYEEEIIHFKKELREPQFR 1098
+G++ Q++Q K E Q L I + ++ +Q+ E E + + +
Sbjct: 1054 VGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENS 1113
Query: 1099 DAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQ 1158
+ +Y +MM ++ E L K L +F S + + I++L R R +
Sbjct: 1114 HLKTEYHKMMDIVAAKEAALIKLQDENKKLS---TRFESSGQDMFRETIQNLSR-IIREK 1169
Query: 1159 DIE 1161
DIE
Sbjct: 1170 DIE 1172
Score = 116 bits (290), Expect = 2e-25
Identities = 159/789 (20%), Positives = 337/789 (42%), Gaps = 79/789 (10%)
Query: 203 VKEYQMELKYLKQYKEKACEIRDQITSKEA-QLTSSKEIVKSYENELDPLKNRLKEIEHN 261
+KE ++E+K L + + DQ++ E +LT +I++ + E+ L R+ H
Sbjct: 1025 IKERELEIKLLNEKNISLTKQIDQLSKDEVGKLT---QIIQQKDLEIQALHARISSTSHT 1081
Query: 262 LSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERK 321
++ L +++A + EK + L EK + + L YH V KE
Sbjct: 1082 -QDVVYLQQQLQAYAMER---EKVFAVLNEKTRE-----NSHLKTEYHKMMDIVAAKEAA 1132
Query: 322 LVDCHRELEKLNKESRLLNQEK-SELLVEQGRL----QLQADRHQEHIRARDSLIQSLAT 376
L+ E +KL+ Q+ E + R+ ++ D + + +++Q+ +T
Sbjct: 1133 LIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSST 1192
Query: 377 QLELDGFERGPFSER-----QIKNFHKLVRERQEGEAKTANQLMNDFAE-KETLKQKQID 430
E G F E ++K K + E ++ T + ++ A+ +E L Q Q
Sbjct: 1193 GNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQ 1252
Query: 431 EIRDKKTGLGRIIELKSEILSKKQNE--LKNVKYELQQLEGSSDRILELDQELIKAEREL 488
+ D ++ I S +QNE LKN EL Q++ S ++ ++L+ + ++
Sbjct: 1253 VLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNT-KDLLLGKLDI 1311
Query: 489 SKAEKNSNVETLKMEVISLQNEKAD-LDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKAD 547
+ +S L+ K++ L + L QE+E+L K +
Sbjct: 1312 ISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELR-------------KSLQE 1358
Query: 548 KDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKE------- 600
KD IR ++ + S+ +++ + S+ K++ + +D L KL KE
Sbjct: 1359 KDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKA 1418
Query: 601 -----LASSEQNKNHIN-NELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSK 654
L+S+E N +N NEL R + +++ ++++ + E D+ +LK E EK +
Sbjct: 1419 KSDQLLSSNENFTNKVNENELLR--QAVTNLKERILIL------EMDIGKLKGENEKIVE 1470
Query: 655 ----QRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPD 710
+ +F L ++ C + ++ E L+E +L +
Sbjct: 1471 TYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLN 1530
Query: 711 KLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKND-IE 769
+KS + + ++ RD+++ + +Q + E+ LR+K N++++RL+N +E
Sbjct: 1531 AVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLE 1590
Query: 770 EQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVN 829
+++ + E+ VT++E + + + QA+ +Q L + V+
Sbjct: 1591 SEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQAS-VQVESLQEQLNVVS 1649
Query: 830 QEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQL-- 887
+++ E +L +++ + + Q ++H + + EK S L++++QL
Sbjct: 1650 KQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQ------QEEKAMYSAELEKQKQLIA 1703
Query: 888 --EEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLN 945
++ L +V SL + +A + E+ KEE I + N++ Q+ L+
Sbjct: 1704 EWKKNAENLEGKVISLQECLDEANAALDSASRLTEQL-DVKEEQIEELKRQNELRQEMLD 1762
Query: 946 DIKEKVKNI 954
D+++K+ ++
Sbjct: 1763 DVQKKLMSL 1771
Score = 105 bits (261), Expect = 4e-22
Identities = 193/1017 (18%), Positives = 408/1017 (40%), Gaps = 125/1017 (12%)
Query: 173 KQKFDEIFSATRYIKALETLRQVRQTQGQKVKE----YQMELKYLKQYKEKACEIRDQIT 228
K+ D + S+ K L L ++ +K+KE Q EL Q K +R I
Sbjct: 790 KETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIE 849
Query: 229 SKEAQLTSSKEIVKSYENELDPLKNRLKEIE-----HNLSKIMKLDNEIKALDSRKKQME 283
K+ L S KE + EL+ L+ L + +L +E+ L++ K+ +E
Sbjct: 850 EKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLE 909
Query: 284 KDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEK 343
++ ++ +E Q + L L +E+++++ + + E++N L EK
Sbjct: 910 EEIKHHQKIIEDQNQSKMQLLQSL--------QEQKKEMDEFRYQHEQMNATHTQLFLEK 961
Query: 344 SELL------VEQGRLQLQADRHQEHIRARDSLIQSLATQLELD-GFERGPFSERQIKNF 396
E + +EQ + QL +R D ++ L ++ G E+ S+ + +
Sbjct: 962 DEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERL 1021
Query: 397 HKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNE 456
K ++ER E E K N EK KQID++ K +G++ ++I+ +K E
Sbjct: 1022 VKGIKER-ELEIKLLN-------EKNISLTKQIDQL--SKDEVGKL----TQIIQQKDLE 1067
Query: 457 LKNVKYELQQLEGSSDRILELDQEL--IKAEREL------SKAEKNSNVET--------- 499
++ + + + D ++ L Q+L ERE K +NS+++T
Sbjct: 1068 IQALHARISSTSHTQD-VVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIV 1126
Query: 500 --LKMEVISLQNEKA-------------------DLDRTLRKLDQEMEQLNHHTTT---- 534
+ +I LQ+E +L R +R+ D E++ L+ T
Sbjct: 1127 AAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAV 1186
Query: 535 --------------RTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWL 580
Q E L +++ +Q++K++ +T++ QL++ L
Sbjct: 1187 LQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEEL 1246
Query: 581 HSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFE- 639
H ++ D +KL + Q+ +LK ++L+ + + +C ++D
Sbjct: 1247 HQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLL 1306
Query: 640 SDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVIS 699
LD + ++ +S A + L++ ++ + + ++ E I
Sbjct: 1307 GKLDIISPQLSSASLLTPQSAECLRASKSEV--LSESSELLQQELEELRKSLQEKDATIR 1364
Query: 700 DLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIID--LKEKEIPELRNKLQNV 757
LQ D + +T +K+ ++ D + + +Q ++ LKEK++ ++ K +
Sbjct: 1365 TLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL-IKAKSDQL 1423
Query: 758 NRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQ--QAAK 815
+ N + E E L + +E + I+E +LK KI + + +
Sbjct: 1424 LSSNENFTNKVNENELLRQAVTNLKER-------ILILEMDIGKLKGENEKIVETYRGKE 1476
Query: 816 LQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQE-QIQHLKSTTNELKSEK 874
+ L T + + +EK+ + ++ K +L++++++ + L N +KS +
Sbjct: 1477 TEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQ 1536
Query: 875 LQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKN 934
+ Q R Q+ + E +L E++ +++ LE+ + E +
Sbjct: 1537 EKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYT 1596
Query: 935 TSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKET---ELNKVIAQLSECE 991
A+D+ +++KV + + N +++ Q E+ +LN V Q E
Sbjct: 1597 REALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETA 1656
Query: 992 KHKEKINEDMRLMRQDI-DTQKIQERWLQDNLTLRKRN-EELKEVEEERKQHLKEMGQMQ 1049
E ++ + + Q + E + Q+ + E+ K++ E K++ + + + +
Sbjct: 1657 LQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENL-EGK 1715
Query: 1050 VLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKK---ELREPQFRDAEEK 1103
V+ ++ + +D+ R L Q +EE I K ELR+ D ++K
Sbjct: 1716 VISLQECLDEANAALDSASR-----LTEQLDVKEEQIEELKRQNELRQEMLDDVQKK 1767
Score = 96.7 bits (239), Expect = 1e-19
Identities = 217/1080 (20%), Positives = 452/1080 (41%), Gaps = 182/1080 (16%)
Query: 190 ETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELD 249
+TL + R+ + + +K+ L L+Q E ++ + + +L + E V+ E
Sbjct: 641 DTLLKEREAEVRNLKQ---NLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECL 697
Query: 250 PLKNRLKEIEHNLSKIMKLDN-EIKA-LDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDL 307
N+L ++ + + +K++ EI+A L KK++ ++ ++ E+ +E++ + + L
Sbjct: 698 AGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSAL 757
Query: 308 YHNHQRTVR---EKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQ--- 361
H+ ++ +K+ ++ + + +E+++ + + S L EQ +L ++ +
Sbjct: 758 QLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFI 817
Query: 362 EHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEK 421
E ++ R S +Q ELD + + + +I ++R G K N + + E+
Sbjct: 818 EKLKERSSKLQE-----ELDKYSQA-LRKNEILRQTIEEKDRSLGSMKEENNHLQEELER 871
Query: 422 ETLKQKQIDEIRDKKTGLGRIIELKSEILSK---KQNELKNVKYELQQLEGSSDRILELD 478
+Q + + D KT L + EL SE+ K++ + +K+ + +E + ++L
Sbjct: 872 LREEQSRTAPVADPKT-LDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLL 930
Query: 479 QELIKAERELSK----------------AEKNSNVETLKMEV----ISLQNEKADLDRTL 518
Q L + ++E+ + EK+ +++L+ + L E+ D+
Sbjct: 931 QSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDN 990
Query: 519 RKLDQE--MEQLN------HHTTTRTQMEMLTKDKADKDEQIRKIKSRH----------- 559
+ QE ++ LN H ++ + E L K +++ +I+ + ++
Sbjct: 991 SDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLS 1050
Query: 560 SDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHIN---NELK 616
DE+ L K LH++ + T+D + L ++L + + + NE
Sbjct: 1051 KDEVGKLTQIIQQKDLEIQALHARISSTSHTQD-VVYLQQQLQAYAMEREKVFAVLNEKT 1109
Query: 617 RKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQ-----RAMLAGATAVYSQFIT 671
R+ L + K+ D+ ++ E+ L +L++E +K S + + M S+ I
Sbjct: 1110 RENSHLKTEYHKMMDIVAAK--EAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIR 1167
Query: 672 QLTDENQSCCPVCQR---VFQTEAELQE---VISDLQSKLRLAPDKLKSTESELKKKEKR 725
+ E + CQ V QT + E V S+ +L DKLK ++KK E+
Sbjct: 1168 EKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQ---QVKKMEEW 1224
Query: 726 RDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESA 785
+ +++ V Q ++E+ +L+ ++ V+ D N+ + Q G I E++
Sbjct: 1225 KQQVMTTVQNMQHESAQLQEELHQLQAQVL-VDSD-----NNSKLQVDYTGLIQSYEQNE 1278
Query: 786 KVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSK 845
T ++ F EL V+ I Q K KLD +S +
Sbjct: 1279 -------TKLKNFGQELAQVQHSIGQLC----------------NTKDLLLGKLDIISPQ 1315
Query: 846 IELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREI 905
+ L E ++ KS SE LQ + R+ L+E+ + T ++ +R +
Sbjct: 1316 LSSASLLTPQSAECLRASKSEVLSESSELLQQELE-ELRKSLQEKDATIRTLQENNHR-L 1373
Query: 906 KDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYI 965
D+ S LE ++E E+ ++ +KEK +D+ +
Sbjct: 1374 SDSIAATSELE------RKEHEQ-----------TDSEIKQLKEK--------QDVLQKL 1408
Query: 966 QDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLR 1025
KD K K +L LS E K+NE+ L+RQ + ++ER L + +
Sbjct: 1409 LKEKDLLIKAKSDQL------LSSNENFTNKVNEN-ELLRQAV--TNLKERILILEMDIG 1459
Query: 1026 K-RNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYE-- 1082
K + E K VE R + ++E+Q L+E N+K + L R+K +E
Sbjct: 1460 KLKGENEKIVETYRGK-------------ETEYQALQET--NMKFSMML---REKEFECH 1501
Query: 1083 ---EEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMK 1139
E+ + F++ L+E + + K E+ ++ + + + ++ + DQ ++ +
Sbjct: 1502 SMKEKALAFEQLLKEKE----QGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQ 1557
Query: 1140 MEEI---NKIIRDLWRSTYRGQDIEYIEIR------SDADENVSASDKRRNYNYRVVMLK 1190
ME N++ R + Q++E + S E ++A D+ +V +L+
Sbjct: 1558 MENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLE 1617
Score = 62.8 bits (151), Expect = 2e-09
Identities = 133/649 (20%), Positives = 276/649 (42%), Gaps = 102/649 (15%)
Query: 190 ETLRQVRQTQGQKVKEY----QMELKYLKQYKEKACEIRDQITSKEAQLTSSKE------ 239
E L Q R Q+VK+ Q + ++ + ++ ++++++ +AQ+ +
Sbjct: 1205 EELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQ 1264
Query: 240 -----IVKSYENELDPLKN---RLKEIEHNLSKIM--------KLDNEIKALDSRKKQME 283
+++SYE LKN L +++H++ ++ KLD L S
Sbjct: 1265 VDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTP 1324
Query: 284 KDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKL----VDCHRELEKLNKESRLL 339
+ L +V + E L +++++EK+ + + HR + + S L
Sbjct: 1325 QSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELE 1384
Query: 340 NQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKL 399
+E + E +L+ + D Q+ ++ +D LI++ + QL L E F+ + +N +L
Sbjct: 1385 RKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQL-LSSNEN--FTNKVNEN--EL 1439
Query: 400 VRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELK---SEILSKKQNE 456
+R+ + L D + + +K ++ R K+T + E S +L +K+ E
Sbjct: 1440 LRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFE 1499
Query: 457 LKNVK-----YELQQLEGSSDRILELDQEL--IKAERELS---KAEKNSNVETLK---ME 503
++K +E E + EL+Q L +K+ +E + + E++ + LK ME
Sbjct: 1500 CHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQME 1559
Query: 504 VISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQM---EMLTKDKADKDEQIRKIKSRHS 560
+LQNE L + +QE+E+L +H E L + D++ ++RK +
Sbjct: 1560 NTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAE--DREAKLRKKVTVLE 1617
Query: 561 DELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEE 620
++L S + +E+ H S ++ +++L ++K+ ++ +L +E
Sbjct: 1618 EKLVS------SSNAMENASHQASVQVESLQEQLNVVSKQ-------RDETALQLSVSQE 1664
Query: 621 QLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSC 680
Q+ Y L ++L + E ++ K AM + Q I + ++
Sbjct: 1665 QVKQYALSL----------ANLQMVLEHFQQEEK--AMYSAELEKQKQLIAEWKKNAEN- 1711
Query: 681 CPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSII 740
+ +V + L E + L S RL +L KE++ +E+ +RQ ++
Sbjct: 1712 --LEGKVISLQECLDEANAALDSASRLT--------EQLDVKEEQIEELKRQNELRQEML 1761
Query: 741 DLKEKEIPELRNKLQ-NVNRDIQR---------LKNDIEEQETLLGTIM 779
D +K++ L N + V++ + R KN E L+G+I+
Sbjct: 1762 DDVQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGSIL 1810
Score = 48.9 bits (115), Expect = 3e-05
Identities = 100/519 (19%), Positives = 208/519 (40%), Gaps = 115/519 (22%)
Query: 729 MLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVC 788
M G + + D + KEI + L++ N +++L D+EE + E++++
Sbjct: 39 MEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEE----------KHEASEIQ 88
Query: 789 LTDVTIMERFQMELKDVE------RKIA--QQAAKLQ--------GIDLDRTVQQVNQEK 832
+ + R Q++ K+VE R+IA Q KLQ G + T +
Sbjct: 89 IKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAY 148
Query: 833 QEKQHKL----------DTVSSKIELNR--KLIQDQQEQIQH---------LKSTTNELK 871
H D +SS+ E+NR + + ++ H + T N +
Sbjct: 149 GISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQ 208
Query: 872 SEKLQISTNLQ-----RRQQLEEQTVELS----------TEVQSLYR-EIKDAKEQVSPL 915
SE ++ ++ R Q++++ E+S TE+ +R E+ D +E++ L
Sbjct: 209 SEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEEL 268
Query: 916 ETTLEK-----FQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKD 970
E L++ + + ++ + T + +K+ K K++ + +KDI + ++
Sbjct: 269 ENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTK-KMEQLEDKIKDINKKLSSAEN 327
Query: 971 --DYKKQKETELNKVIAQ-LSECE--------------KHKEKINEDMRLMRQDIDTQKI 1013
D ++++ +LN Q + ECE K + + E R++ Q +++
Sbjct: 328 DRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEV 387
Query: 1014 ---------------------QERWL-QDNLTLRKRNEELKEVEEERKQHLKEMGQMQVL 1051
Q+ L +DNL L+ R E L++ + Q +E+ QM +L
Sbjct: 388 FRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEEL-QMSLL 446
Query: 1052 QMKSEHQKLE----ENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREM 1107
++ +E++ ++ +I H+L L + +E+ ++ +E + EE R+
Sbjct: 447 KLNNEYEVIKSTATRDISLDSELHDLRLNLEA--KEQELNQSISEKETLIAEIEELDRQN 504
Query: 1108 MIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKI 1146
+ L+ L D I K +E ++
Sbjct: 505 QEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRV 543
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 137 bits (344), Expect = 9e-32
Identities = 208/1042 (19%), Positives = 442/1042 (42%), Gaps = 179/1042 (17%)
Query: 190 ETLRQVRQTQGQKVK-EYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENEL 248
E L + Q +K ++Q+E K +K+ E+A E ++I A+LT+ K + E+E
Sbjct: 897 ENLLDAEERCDQLIKAKFQLEAK-IKEVTERA-EDEEEIN---AELTAKK---RKLEDEC 948
Query: 249 DPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLY 308
LK + ++E L+K+ K E A +++ K + ++ S G DE + L
Sbjct: 949 SELKKDIDDLELTLAKVEK---EKHATENKVKNLTEELS-----------GLDETIAKLT 994
Query: 309 HNHQRTVREKERKLVDCHRELEK---LNKESRLLNQEKSEL---LVEQGRLQLQADRHQE 362
+ ++ L D E +K LNK L Q+ +L L ++ +L++ +R++
Sbjct: 995 REKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKR 1054
Query: 363 HIRARDSLIQSLATQLELD------GFERGPFSERQIKN-----------FHKLVRERQE 405
+ L Q LE D ++ F Q+++ F K ++E Q
Sbjct: 1055 KLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQA 1114
Query: 406 GEAKTANQLMNDFAEK-ETLKQ-----KQIDEIRDKKTGLGRIIELKSEILSKKQNELKN 459
+ ++ + A + +T KQ ++++E+ ++ G + + E+ K++ E
Sbjct: 1115 RIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLK 1174
Query: 460 VKYELQQL------------EGSSDRILELDQEL-----IKAERELSKAEKNSNVETLKM 502
++ +L++ + +D + EL +++ +K + E K+E ++ L
Sbjct: 1175 LRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSS 1234
Query: 503 EVISLQNEKADLDRTLRKL-DQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSD 561
+ S+ KA+L++ R L DQ E + + + LT K+ + ++ SR +
Sbjct: 1235 SMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGEL-SRQLE 1293
Query: 562 ELTSLLGYFPNKKQL----EDWLHSKSKEINQTRDRLAK-----------LNKELASSEQ 606
E S++ KQ + L + +E N+ ++ LA L ++ ++
Sbjct: 1294 EKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQE 1353
Query: 607 NKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVY 666
K + L + +++ + K +E+D + EE+E++ K+ A
Sbjct: 1354 GKAELQRALSKANSEVAQWRTK---------YETDAIQRTEELEEAKKKLA--------- 1395
Query: 667 SQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRR 726
Q + ++ ++ C + +T+ LQ + DL + ++ S + L KK++
Sbjct: 1396 -QRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDV----ERANSLAAALDKKQRNF 1450
Query: 727 DEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAK 786
D++L ++ + + E+ + ++++ ++ +LKN EE L T+ E ++ +
Sbjct: 1451 DKVLA---EWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLE 1507
Query: 787 VCLTDVT--IMER--------------------FQMELKDVERKIAQQAAKLQGIDLDRT 824
+ D+T I E Q+ L++ E + + AK+ I L+ T
Sbjct: 1508 QEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELT 1567
Query: 825 V-------------QQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELK 871
+++ Q K+ Q ++T+ S ++ ++ + E I+ K +L
Sbjct: 1568 QVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAE---VRSRNEAIRLKKKMEGDLN 1624
Query: 872 SEKLQIS-------TNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQ 924
++Q+S L+ + ++ Q + + R +D KEQ++ +E Q
Sbjct: 1625 EIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQA 1684
Query: 925 EKEEL---INKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELN 981
E EEL + + + K+A+ +L D E+V+ +H + + KK+ ET+L
Sbjct: 1685 EVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIH--------TKKKLETDLM 1736
Query: 982 KVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQD-NLTLRKRNEELKEVEEERKQ 1040
++ +++ + + E + D + + QD + L + + L++ ++ +
Sbjct: 1737 QLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQH 1796
Query: 1041 HLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDA 1100
L E Q+ + K + QKLE I ++ G QK E + K LR+ + R
Sbjct: 1797 RLDEAEQLALKGGKKQIQKLETRIRELEFELE---GEQKKNTESV----KGLRKYERRVK 1849
Query: 1101 EEKYR---EMMIVMRTTELVNK 1119
E Y+ + V+R +LV+K
Sbjct: 1850 ELTYQSEEDRKNVLRLQDLVDK 1871
Score = 81.6 bits (200), Expect = 4e-15
Identities = 123/601 (20%), Positives = 261/601 (43%), Gaps = 113/601 (18%)
Query: 575 QLEDWLHSKSKEINQTRDRLAK-------LNKELASSEQNKNHINNELKRKEEQLSSYED 627
+ E + + +E +T+D LAK L ++L + Q KN + +++ + E L E+
Sbjct: 845 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEE 904
Query: 628 KLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRV 687
+ D F+ + ++KE E++ + + A TA +L DE C +
Sbjct: 905 RC-DQLIKAKFQLEA-KIKEVTERAEDEEEINAELTAKK----RKLEDE-------CSEL 951
Query: 688 FQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEI 747
+ +L+ ++ ++ + +K+K+ EL + + + L ++++ + ++ +
Sbjct: 952 KKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLD---ETIAKLTREKKALQEAHQQAL 1008
Query: 748 PELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVER 807
+L+ + VN + + K+ +E+Q L + + +E+ +V L ER + +L+ +
Sbjct: 1009 DDLQAEEDKVN-SLNKTKSKLEQQVEDLESSLEQEKKLRVDL------ERNKRKLEG-DL 1060
Query: 808 KIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTT 867
K+AQ++ +DL+ QQ+++ ++K + + SK+E + L Q++I+ L++
Sbjct: 1061 KLAQESI----LDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARI 1116
Query: 868 NELKSE------------------------------------KLQISTNLQR-------R 884
EL+ E QI N +R R
Sbjct: 1117 EELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLR 1176
Query: 885 QQLEEQTVELSTEVQSLYRE----IKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIA 940
+ LEE T++ V +L ++ + + EQ+ L+ +K ++EK E K+
Sbjct: 1177 RDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEF--------KLE 1228
Query: 941 QDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKI-NE 999
D L+ E V ++ I ++D + + + E ++ LSE K ++ E
Sbjct: 1229 IDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNE----EIQRSLSELTTQKSRLQTE 1284
Query: 1000 DMRLMRQDIDTQKIQERWLQDNLTLRKRNEELK-EVEEERK-----QHLKEMGQMQVLQM 1053
L RQ + + I + + ++ EELK ++EEE K H + + +
Sbjct: 1285 AGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLL 1344
Query: 1054 KSEHQKLEENIDNIKR-----NHNLALGRQKGYEEEIIHFKKELRE------PQFRDAEE 1102
+ ++++ +E ++R N +A R K YE + I +EL E + +D+EE
Sbjct: 1345 REQYEEEQEGKAELQRALSKANSEVAQWRTK-YETDAIQRTEELEEAKKKLAQRLQDSEE 1403
Query: 1103 K 1103
+
Sbjct: 1404 Q 1404
Score = 47.8 bits (112), Expect = 7e-05
Identities = 72/323 (22%), Positives = 139/323 (43%), Gaps = 57/323 (17%)
Query: 187 KALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYEN 246
+A ETL+ +R QGQ +K+ Q+ L + +E ++++Q+ E + + V+
Sbjct: 1636 QAAETLKHLRSVQGQ-LKDTQLHLDDALRGQE---DLKEQLAIVERRANLLQAEVEELRA 1691
Query: 247 ELDPLKNRLKEIEHNL----SKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDE 302
L+ + K E L ++ L + +L KK++E D +L+ ++E +
Sbjct: 1692 TLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDA-- 1749
Query: 303 QLNDLYHNHQRTVREKERK-LVDCHRELEKLNKE---SRLLNQEKSELLVEQGRLQLQAD 358
R EK +K + D E+L KE S L + K L LQ + D
Sbjct: 1750 ----------RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLD 1799
Query: 359 RHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQ---EGEAKTANQLM 415
A QL L G ++QI+ +RE + EGE K + +
Sbjct: 1800 E---------------AEQLALKG------GKKQIQKLETRIRELEFELEGEQKKNTESV 1838
Query: 416 NDFAEKE-TLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRI 474
+ E +K+ D+K ++ L+ +++ K Q ++K+ K + ++ + ++
Sbjct: 1839 KGLRKYERRVKELTYQSEEDRK----NVLRLQ-DLVDKLQVKVKSYKRQAEEADEQANAH 1893
Query: 475 LELDQELIKAERELSKAEKNSNV 497
L + KA+ EL +AE+ +++
Sbjct: 1894 L---TKFRKAQHELEEAEERADI 1913
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 136 bits (343), Expect = 1e-31
Identities = 198/1010 (19%), Positives = 436/1010 (43%), Gaps = 157/1010 (15%)
Query: 201 QKVKEYQMELKYLKQYKEKACE-IRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIE 259
++ +E EL K+ E C ++ I E LT ++ + EN++ L + +E
Sbjct: 931 EEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALE 990
Query: 260 HNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKME---KVFQGTDEQLNDLYHNHQRTVR 316
N+SK+ K E K+L +Q D E+K+ K+ ++Q +DL +
Sbjct: 991 ENISKLTK---EKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGS-----L 1042
Query: 317 EKERKL-VDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLA 375
E+E+KL D R KL E L ++S + +E + Q++ E ++ ++ + L
Sbjct: 1043 EQEKKLRADLERAKRKL--EGDLKMSQESIMDLENDKQQIE-----EKLKKKEFELSQLQ 1095
Query: 376 TQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDK 435
+++ + F +++IK + E +E E + + L ++ + ++++EI ++
Sbjct: 1096 AKIDDEQVHSLQF-QKKIKELQARIEELEE-EIEAEHTLRAKIEKQRSDLARELEEISER 1153
Query: 436 KTGLGRIIELKSEILSKKQNELKNVKYELQQL------------EGSSDRILELDQEL-- 481
+ E+ K++ E + ++ +L++ + +D + EL +++
Sbjct: 1154 LEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDN 1213
Query: 482 ---IKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQM 538
+K + E K+E ++ + + +L K++++RT R ++ + ++ +TQ+
Sbjct: 1214 LQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQL 1273
Query: 539 -EMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKL 597
L KA Q ++ R +E SL+ KQ L + +E+ + + K
Sbjct: 1274 IHDLNMQKARLQTQNGELSHR-VEEKESLISQLTKSKQA---LTQQLEELKRQMEEETKA 1329
Query: 598 NKELASSEQNKNH---INNELKRKEEQLSSYEDKLFDVCGSQ------DFESDLDRLKEE 648
+A + Q+ H + E +E++ + + S+ +E+D + EE
Sbjct: 1330 KNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEE 1389
Query: 649 IEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLA 708
+E++ K+ A Q + + + ++ C + +T+ LQ + DL L +
Sbjct: 1390 LEEAKKKLA----------QRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERS 1439
Query: 709 ---------------------PDKLKSTESELKKKEKR-RDEMLGLVPMR---QSIIDLK 743
KL +++EL+ +K R L MR + ++D
Sbjct: 1440 HTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQL 1499
Query: 744 E---KEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVT-IMERFQ 799
E +E L+ ++ ++ I +++E E + E+ +V L +V +E +
Sbjct: 1500 ETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEE 1559
Query: 800 MELKDVERKIAQQAAKLQG--IDLDRTVQQVNQEKQEKQHKLDTV--------SSKIELN 849
++ V+ +++Q ++L I+ D ++Q+ + Q L +V + + L
Sbjct: 1560 SKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLK 1619
Query: 850 RKLIQDQQE-QIQ-------------HLKSTTNELKSEKLQISTNLQRRQQLEEQTVELS 895
+K+ D E +IQ HL++ +LK +L + L+ + L+EQ +
Sbjct: 1620 KKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVE 1679
Query: 896 TEVQSLYREIKDAKEQVSPLETTLEKFQQE------KEELINKKNTSNKIAQDKLNDIKE 949
L E+++ K + E T +QE + +L++ +NTS +N K+
Sbjct: 1680 RRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTS------LINTKKK 1733
Query: 950 KVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDID 1009
+I ++EN IQ+ ++ +K K+ + A ++E K ++ + + M+++++
Sbjct: 1734 LEADIAQCQAEVENSIQESRNAEEKAKKAITD--AAMMAEELKKEQDTSAHLERMKKNLE 1791
Query: 1010 TQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKR 1069
Q +++ LQ L +E +Q + G+ Q+ ++++ ++LE +D ++
Sbjct: 1792 -QTVKD--LQHRL-------------DEAEQLALKGGKKQIQKLENRVRELENELDVEQK 1835
Query: 1070 NHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNK 1119
AL YE ++ KE+ AEE ++ ++R +LV+K
Sbjct: 1836 RGAEALKGAHKYERKV----KEMT----YQAEEDHKN---ILRLQDLVDK 1874
Score = 126 bits (316), Expect = 2e-28
Identities = 210/989 (21%), Positives = 400/989 (40%), Gaps = 141/989 (14%)
Query: 74 QETDVRAQIRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITRTKHGEKVSLSSKC 133
QE +RA + R + G+L Q S++ + K+ + L+ ++ LS
Sbjct: 1044 QEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKK--------KEFELSQLQ 1095
Query: 134 AEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLR 193
A+ID E + SL K + K L+ + +E+ I+A TLR
Sbjct: 1096 AKIDDEQVHSLQFQKKI-------------------KELQARIEEL---EEEIEAEHTLR 1133
Query: 194 QVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKN 253
K+++ + +L + EI +++ ++ E+ K E E ++
Sbjct: 1134 A-------KIEKQRSDLA------RELEEISERLEEASGATSAQIEMNKKREAEFQKMRR 1180
Query: 254 RLKE--IEHNLS----------KIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTD 301
L+E ++H + + +L +I L K+++EK+ SEL+ +++ +
Sbjct: 1181 DLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNI- 1239
Query: 302 EQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQ 361
E L+ N +RT R E + + + E+ + LN +K+ L + G L + + +
Sbjct: 1240 EALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKE 1299
Query: 362 EHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEK 421
I Q+L QLE +L R+ +E E K N + +
Sbjct: 1300 SLISQLTKSKQALTQQLE------------------ELKRQMEE-ETKAKNAMAHALQSS 1340
Query: 422 E---TLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKN--VKYELQQLEGSSDRILE 476
L ++Q +E ++ K L R LSK +E+ KYE ++ R E
Sbjct: 1341 RHDCDLLREQYEEEQEAKAELQRA-------LSKANSEVAQWRTKYETDAIQ----RTEE 1389
Query: 477 LDQELIKAERELSKAEKNSNVETLKMEVIS-----LQNEKADLDRTLRKLDQEMEQLNHH 531
L++ K + L +AE+N+ K + LQ E DL R L + L+
Sbjct: 1390 LEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKK 1449
Query: 532 TTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNK-KQLEDWLHSKSKEINQT 590
++ K K D+ + + + S L++ L N +++ D L + +E
Sbjct: 1450 QRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNL 1509
Query: 591 RDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFE-SDLDRLKEEI 649
++ ++ L +++A + +N K E++ S + L +V GS + E S + R++ E+
Sbjct: 1510 QEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLEL 1569
Query: 650 EKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAP 709
S+ ++ L + I QL +Q Q V E I LRL
Sbjct: 1570 ---SQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAE------IRSRNDALRLK- 1619
Query: 710 DKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIE 769
K E +L + E + + Q + + ++ + + L + R + LK +
Sbjct: 1620 ---KKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLA 1676
Query: 770 EQETLLGTIMPEEESAKVCLTDVTIMERF-QMELKDVERKIAQQAAKLQGIDLDRTVQQV 828
E G ++ E E KV L R + EL D ++ Q Q L T +++
Sbjct: 1677 IVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRV--QLLHSQNTSLINTKKKL 1734
Query: 829 NQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLE 888
+ + Q + V + I+ +R + ++ I ELK E+ S +L+R ++
Sbjct: 1735 EADIAQCQAE---VENSIQESRNAEEKAKKAITDAAMMAEELKKEQ-DTSAHLERMKKNL 1790
Query: 889 EQTVE----LSTEVQSLY-----REIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKI 939
EQTV+ E + L ++I+ + +V LE L+ Q+ E + + +
Sbjct: 1791 EQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERK 1850
Query: 940 AQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINE 999
++ +E KNI ++D+ + +Q YK+Q E + QLS C + + ++ E
Sbjct: 1851 VKEMTYQAEEDHKNILR-LQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEE 1909
Query: 1000 -------------DMRLMRQDIDTQKIQE 1015
+R +D+ +QK++E
Sbjct: 1910 AAERADIAESQVNKLRAKSRDVGSQKMEE 1938
Score = 84.3 bits (207), Expect = 7e-16
Identities = 156/802 (19%), Positives = 326/802 (40%), Gaps = 150/802 (18%)
Query: 488 LSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQL-NHHTTTRTQMEMLTKDKA 546
L AE + T+K + + E A + ++L+++M L + Q++ T++
Sbjct: 844 LKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLM 903
Query: 547 DKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQ 606
D +E+ G +K LE +K KE+ + + ++N EL + ++
Sbjct: 904 DAEERCE--------------GLIKSKILLE----AKVKELTERLEEEEEMNSELVAKKR 945
Query: 607 NKNHINNELKRK-----------EEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQ 655
N + LKR E++ + E+K+ ++ ++ L+E I K +K+
Sbjct: 946 NLEDKCSSLKRDIDDLELTLTKVEKEKHATENKV------KNLSEEMTALEENISKLTKE 999
Query: 656 RAMLAGA-----------------TAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVI 698
+ L A + + Q TD+ + ++ + A+L+
Sbjct: 1000 KKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGS---LEQEKKLRADLERAK 1056
Query: 699 SDLQSKLRLAPDKL-------KSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELR 751
L+ L+++ + + + E +LKKKE ++ + Q +K+I EL+
Sbjct: 1057 RKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQ 1116
Query: 752 NKLQNVNRDIQ---RLKNDIEEQETLLGTIMPE-----EESAKVCLTDVTIMER----FQ 799
+++ + +I+ L+ IE+Q + L + E EE++ + + ++ FQ
Sbjct: 1117 ARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQ 1176
Query: 800 MELKDVE--------------RKIAQQAAKL--QGIDLDRTVQQVNQEKQEKQHKLDTVS 843
+D+E +K A A+L Q +L R Q++ +EK E + ++D ++
Sbjct: 1177 KMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMA 1236
Query: 844 SKIELNRKLIQDQQEQIQHLKSTTNELKS---EKLQISTNL-QRRQQLEEQTVELSTEVQ 899
S IE K + + + ++ +E+K+ ++ Q+ +L ++ +L+ Q ELS V+
Sbjct: 1237 SNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVE 1296
Query: 900 SLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLND---IKEKVKNIHG 956
I + L LE+ +++ EE KN Q +D ++E+ +
Sbjct: 1297 EKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQE 1356
Query: 957 YMKDIENYIQDGKDD---YKKQKET----------ELNKVIAQ-LSECEKHKEKINE--- 999
+++ + + ++ + ET E K +AQ L E E++ E N
Sbjct: 1357 AKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCA 1416
Query: 1000 -----DMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMG-------- 1046
RL + D + ER TL K+ +V E KQ L E
Sbjct: 1417 SLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQK 1476
Query: 1047 -----QMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQ--FRD 1099
++ +M++ ++++ + ++ ++R + E+I K L+E + +
Sbjct: 1477 ESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKL 1536
Query: 1100 AEEKYREMMIVMRTTE-----------LVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIR 1148
E++ ++ + + E V +L LD+ +++ K EEI ++ R
Sbjct: 1537 VEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIE----KDEEIEQLKR 1592
Query: 1149 DLWRSTYRGQDIEYIEIRSDAD 1170
+ R+ Q + EIRS D
Sbjct: 1593 NSQRAAEALQSVLDAEIRSRND 1614
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 136 bits (342), Expect = 2e-31
Identities = 250/1230 (20%), Positives = 518/1230 (42%), Gaps = 204/1230 (16%)
Query: 67 VHDPKVAQETDVRAQ-IRLQ-------FRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVI 118
+ DPK ++T A+ + L R N EL + + T K + + + + +
Sbjct: 617 IEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQL 676
Query: 119 TRTKHGEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCH----------QEDSNWPLSE 168
K +V L + E+ + + + C+ Q++ N + E
Sbjct: 677 -EAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEE 735
Query: 169 GKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQ---YKEKACE-IR 224
+AL+++ + +E LR+ Q + +++ E L +KE + +
Sbjct: 736 NEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLL 795
Query: 225 DQITSKEAQLTSSKEIVKSYENELDPLKNR-----------LKEIEHNLSKIMKLDNEIK 273
++I + L +++ KS + E K L+E E +I+ L E +
Sbjct: 796 EEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQ 855
Query: 274 ALDSR----KKQMEKDNSELEEKMEKVFQGTDE--QLNDLYHNHQRTVREKERKLVDCHR 327
DS K ++ EL+EK +V + +E QL + N T++ ER+
Sbjct: 856 KFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITE 915
Query: 328 ELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGP 387
+L++ +E + L QEK +L Q LQ++ D+ + I D++ ++ TQ
Sbjct: 916 KLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIH--DTVNMNIDTQ---------- 963
Query: 388 FSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKS 447
Q++N + +++ QE T N TLK K +E+ S
Sbjct: 964 ---EQLRNALESLKQHQE----TIN----------TLKSKISEEV--------------S 992
Query: 448 EILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISL 507
L ++N K E QQ D+ +L+ K + L+ K++ + + ++ SL
Sbjct: 993 RNLHMEENT-GETKDEFQQKMVGIDKKQDLEA---KNTQTLTADVKDNEIIEQQRKIFSL 1048
Query: 508 QNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLL 567
EK +L + L + E EQL T + +EM +++ E++R + DEL
Sbjct: 1049 IQEKNELQQMLESVIAEKEQLK--TDLKENIEMTIENQ----EELRLL----GDELKKQQ 1098
Query: 568 GYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYED 627
+K + K E+++T DRLA++ ++L Q +L +E++S +
Sbjct: 1099 EIVAQEK---NHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQK 1155
Query: 628 KLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRV 687
K+ ++ ++ +++L + +E +R LA + + +T E + + Q+
Sbjct: 1156 KINEI---ENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKEL-QKS 1211
Query: 688 FQTEAE-LQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKE 746
F+TE + L+ I ++++ ++LK LK+ ++ DE+ V + + I + ++
Sbjct: 1212 FETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQI-INTQD 1270
Query: 747 IPELRNKLQN---VNRDIQRLKNDIEE----QETLLGTIMPEEESAKVCLTDVTIMERFQ 799
+ + KLQ V + Q L +++E QET+ + E+S D T + R +
Sbjct: 1271 LEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTT---KDSTTLARIE 1327
Query: 800 MELKDVERKIAQQAAKLQGIDLDR----TVQQVNQEKQE--KQHKLDTVSSKIELNRKLI 853
ME + K + +++ + +R T+++ + K + K+H +T++ E K
Sbjct: 1328 MERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSK-- 1385
Query: 854 QDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVS 913
Q+Q ++ + T ++ SE Q ++E + + LS +Q + E+K ++
Sbjct: 1386 QEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKD 1445
Query: 914 PLETTLEKFQ-------------------------------QEKEELINKKNTS------ 936
L+ E Q +E+EE IN+ +
Sbjct: 1446 DLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKET 1505
Query: 937 ------------NKIAQDKLNDIKEKVKNIH-GYMKDIENYIQDGKD--DYKKQKETELN 981
N Q+K+ +I EK + + + +++ + + K +++K K++ L
Sbjct: 1506 EISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQ 1565
Query: 982 KVIAQLSECEKHKEKINEDMRLM-RQDIDTQKIQERWLQDNLTLRKRNEE----LKEVEE 1036
+ +++ E ++ E++++M ++ + +++QE + L++ +E +KE +E
Sbjct: 1566 SIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQE 1625
Query: 1037 ERKQHLK---------EMGQMQVLQMKSEHQKLE-ENI--DNIK----RNHNLALGRQKG 1080
+ Q LK +M +++ L+ + E QKL ENI +NI+ + NL R
Sbjct: 1626 KEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVT 1685
Query: 1081 YEEEIIHFKKELREPQFRDAEEKYREMMI----VMRTTELVNKDLDIYYKTLDQAIMKFH 1136
E + + +E + + +E RE + ++V+ L + +T+D+ +
Sbjct: 1686 KERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDK-LRGIV 1744
Query: 1137 SMKMEEINKIIRDLWRS--TYRGQDIEYIE 1164
S K EI+ + +DL S + QD++ E
Sbjct: 1745 SEKTNEISNMQKDLEHSNDALKAQDLKIQE 1774
Score = 123 bits (308), Expect = 1e-27
Identities = 199/980 (20%), Positives = 435/980 (44%), Gaps = 124/980 (12%)
Query: 166 LSEGKALKQKFDEIFSATRYIKA-----LETLRQVRQTQGQKVKEYQMELKYLKQYKEKA 220
L E +++ ++ D++ S +K E LR+ +K +E ++ +LK+++E
Sbjct: 1678 LEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETI 1737
Query: 221 CEIR-------DQITSKEAQLTSSKEIVKSYE----NELDPLKNRLKEIEHNLSKIMKLD 269
++R ++I++ + L S + +K+ + EL LKE + + K+ +
Sbjct: 1738 DKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIV 1797
Query: 270 NE-IKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRE 328
+E L + +K +E N++L+EK++++ + + QL L ++ V E ++K+ + +
Sbjct: 1798 SEKTDKLSNMQKDLENSNAKLQEKIQEL-KANEHQLITL----KKDVNETQKKVSEMEQL 1852
Query: 329 LEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLAT-QLELDGFERGP 387
+++ +S L++ + E L +L + + ++ RD+L + T +LE D
Sbjct: 1853 KKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERD------ 1906
Query: 388 FSERQIKNFHKLVRERQ---EGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIE 444
Q+K + + R + E KTA L + KET +D++R+K
Sbjct: 1907 ----QLKESLQETKARDLEIQQELKTARMLSKE--HKET-----VDKLREK--------- 1946
Query: 445 LKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEV 504
+S+K ++ +++ +L + S D + + QEL K E +L + +++ N+ K+
Sbjct: 1947 -----ISEKTIQISDIQKDLDK---SKDELQKKIQELQKKELQLLRVKEDVNMSHKKI-- 1996
Query: 505 ISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELT 564
NE L + + M+ + R LTK + E+IR I ++ DEL
Sbjct: 1997 ----NEMEQLKKQFEAQNLSMQSV------RMDNFQLTKKLHESLEEIR-IVAKERDELR 2045
Query: 565 SLLGYFPNKKQLEDWLHSKSKEINQTR-DRLAKLNKELASSEQNKNHINNELKRKEEQLS 623
+ K + + ++ + + I + R + K K L S Q H+ L+ E+ S
Sbjct: 2046 RIKESL--KMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQ--HLTESLR---EKCS 2098
Query: 624 SYEDKLFDVCGSQDFESDLDRLKEEIEKS---SKQRAMLAGATA----VYSQFITQLTDE 676
++ L D L+RL ++EK K+ +M A + ++ I +L
Sbjct: 2099 RIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTA 2158
Query: 677 NQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMR 736
NQ C R+ + +L+ V+S + + + E + + +++ E+L +
Sbjct: 2159 NQRCSMEFHRIMK---KLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHL 2215
Query: 737 QSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVT--- 793
Q D+ +E+ +L+ QN++ I+ + D E E +I E + ++T
Sbjct: 2216 QQDCDVPSRELRDLKLN-QNMDLHIEEILKDFSESE--FPSIKTEFQQVLSNRKEMTQFL 2272
Query: 794 ---IMERFQME-LKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELN 849
+ RF +E LK+ +K + ++ +R + +N E E + + T+S + E +
Sbjct: 2273 EEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMN-ESTEFEERSATISKEWEQD 2331
Query: 850 RKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQ--RRQQLEEQTVELSTE-VQSLYREIK 906
K ++++ E++ T + Q++ Q + + + +L+TE ++ L +
Sbjct: 2332 LKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLH 2391
Query: 907 DAKEQVSPLETTLEKFQQEKEELINKKNTSNKIA--QDKLNDIKEKVKNIHGYMKDIENY 964
+AKE E+ + K Q+E E T++ IA Q K+++ + ++ ++ +++
Sbjct: 2392 EAKESAMHKESKIIKMQKELEV------TNDIIAKLQAKVHESNKCLEKTKETIQVLQDK 2445
Query: 965 IQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTL 1024
+ G YK++ E K++ E K+ ++ +++ + ++ QK R L++NL
Sbjct: 2446 VALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRR 2505
Query: 1025 RKRNEELKEVEEERKQHLKE-----------MGQMQVLQMKSEHQKLEENIDNIKRNHNL 1073
++ ++ + E + + L +KSEH +LE+ I +K+ +
Sbjct: 2506 SQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQ 2565
Query: 1074 ALGRQKGYEEEIIHFKKELR 1093
+ ++ H E++
Sbjct: 2566 LIKQKNELLSNNQHLSNEVK 2585
Score = 122 bits (307), Expect = 2e-27
Identities = 220/1041 (21%), Positives = 450/1041 (43%), Gaps = 175/1041 (16%)
Query: 159 QEDSNWPLSEGKALKQKF--DEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQY 216
++D L E K L QK ++I + TR + +L ++ + ++ + L + +
Sbjct: 372 EKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKM 431
Query: 217 KEK----ACEIRDQITSKEAQLTSS--KEIVKSYENELDPLKNRL---KEIEHN-LSKIM 266
K I IT+K +L+ + +EI +S +E D N L EIE N +K++
Sbjct: 432 KNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLL 491
Query: 267 KLDNEIKALDSRK----------KQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVR 316
+N L+S + +Q+ + E+E K+++ L++ ++T +
Sbjct: 492 NQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKE-----KNDLDEFEALERKTKK 546
Query: 317 EKERKLVDCHRELEKLNKESRLLNQE-------KSELLVEQG----RLQLQADRHQ---- 361
++E +L+ L+ L K + + NQ+ K ELL E+ +LQ D +
Sbjct: 547 DQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENI 606
Query: 362 --------EHIRARDSLIQSL--ATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTA 411
E I + Q+L A + LD F +++ + ++E+ + A T
Sbjct: 607 KMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAF----LRSENLELKEKMKELATTY 662
Query: 412 NQLMNDF----AEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELK-NVKYELQQ 466
Q+ ND ++ E K+ Q+D ++ ++ I +L S I K +L N+ +
Sbjct: 663 KQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNL-----E 717
Query: 467 LEGS-SDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEM 525
LEG +D EL++E+ + E + S +++L EV L+ E D L + E
Sbjct: 718 LEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEK 777
Query: 526 EQLNH---HTTTRTQ--MEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWL 580
++L H +R Q +E + K K D KS + F N K L
Sbjct: 778 DKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQE--------FQNFKTLHMDF 829
Query: 581 HSKSKEINQTRDRL----AKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQ 636
K K + + +R+ L+KE + + + EL K ++L ++K +V Q
Sbjct: 830 EQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQEL---QEKTREV---Q 883
Query: 637 DFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQ- 695
+ +++++LKE++E + + ++ + Q +E ++ + Q + LQ
Sbjct: 884 ERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQI 943
Query: 696 -------------EVISDLQSKLRLAPDKLKSTESELKK-KEKRRDEMLGLVPM------ 735
+ D Q +LR A + LK + + K K +E+ + M
Sbjct: 944 ERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGE 1003
Query: 736 -----RQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLT 790
+Q ++ + +K+ E +N Q + D++ N+I EQ+ + +++ E+ + L
Sbjct: 1004 TKDEFQQKMVGIDKKQDLEAKNT-QTLTADVK--DNEIIEQQRKIFSLIQEKNELQQMLE 1060
Query: 791 DVTI-MERFQMELKD-VERKIA-QQAAKLQGIDLDRTVQQVNQEKQ-------------- 833
V E+ + +LK+ +E I Q+ +L G +L + + V QEK
Sbjct: 1061 SVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCD 1120
Query: 834 ---EKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQ 890
E + KL S +++ ++ + + QE++ ++ NE+++ K ++ + +E +
Sbjct: 1121 RLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETE 1180
Query: 891 TVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEK 950
+EL+ ++ Y E+K ++ L+ + F+ E++ L + +I L KE+
Sbjct: 1181 RLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHL---RGYIREIEATGL-QTKEE 1236
Query: 951 VKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQD--- 1007
+K H ++K+ + I D ++ +E I + EK K+ E++ ++ ++
Sbjct: 1237 LKIAHIHLKEHQETI-----DELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQEL 1291
Query: 1008 -------IDTQK--------IQERWLQDNLTLR-------KRNEELKEVEEERKQHLKEM 1045
+TQ+ ++ +D+ TL + NE+ +E +EE K KE
Sbjct: 1292 LPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKER 1351
Query: 1046 GQMQVLQ--MKSEHQKLEENI 1064
++ ++ ++ +H +L+E+I
Sbjct: 1352 DNLKTIKEALEVKHDQLKEHI 1372
Score = 110 bits (276), Expect = 7e-24
Identities = 195/1029 (18%), Positives = 448/1029 (43%), Gaps = 152/1029 (14%)
Query: 187 KALETLRQVRQTQGQKV--KEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSY 244
K LE + Q + Q++ KE Q +K + + +EK E++ ++A+ ++S
Sbjct: 1512 KQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK----DSALQSI 1567
Query: 245 ENELDPLKNRLKEIEHNLSKIMKLDNEIK----ALDSRKKQMEKDNSELEEKM----EKV 296
E+++ L NRL+E + + ++K E+K AL + Q++++ E+ KM EK
Sbjct: 1568 ESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKE 1627
Query: 297 FQ--------GTDEQLNDLYHNHQRTVREK------ERKLVDCHRELEKLNKESRLLNQE 342
+Q T E++ ++ H ++ +K E + + + L + +E R + +E
Sbjct: 1628 YQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKE 1687
Query: 343 KSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFE-------------RGPFS 389
+ +L + L+++ D+ +E++ R+++ + L Q EL RG S
Sbjct: 1688 RDDLRSVEETLKVERDQLKENL--RETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVS 1745
Query: 390 ER--QIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKS 447
E+ +I N K + E K + + + + K+ E DK G I+ K+
Sbjct: 1746 EKTNEISNMQKDL-EHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRG---IVSEKT 1801
Query: 448 EILSKKQNELKN----VKYELQQLEGSSDRILELDQELIKAERELSKAEK-NSNVETLKM 502
+ LS Q +L+N ++ ++Q+L+ + +++ L +++ + ++++S+ E+ ++ +
Sbjct: 1802 DKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSL 1861
Query: 503 EVISLQNEKADLDRTLRKLDQEMEQ-LNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSD 561
+ L+ E +L + L + +EM+ + R E L ++ E +++ K+R +
Sbjct: 1862 TLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLE 1921
Query: 562 ELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQ 621
L K+ ++ + ++I++ +++ + K+L S+ EL++KE Q
Sbjct: 1922 IQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQ 1981
Query: 622 LSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCC 681
L ++ DV S +++++LK++ E + L+ + F QLT +
Sbjct: 1982 LLRVKE---DVNMSHKKINEMEQLKKQFEAQN-----LSMQSVRMDNF--QLTKKLHESL 2031
Query: 682 PVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIID 741
+ V + EL+ + + L++ D+ +T E+ ++++ + + P ++ + D
Sbjct: 2032 EEIRIVAKERDELRRI----KESLKMERDQFIATLREMIARDRQNHQ---VKPEKRLLSD 2084
Query: 742 LKEKEIPELRNKLQNVNRDIQR-----------------LKNDIEEQETLLGTI-----M 779
++ LR K + ++R L+ +IE Q+ L + +
Sbjct: 2085 GQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSL 2144
Query: 780 PEEESAKV---------CLTDV-TIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVN 829
P ++ + C + IM++ + L V + +Q + ++D + +V
Sbjct: 2145 PYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMD-FIDEVE 2203
Query: 830 QEK------QEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNE-----LKSEKLQIS 878
++K Q Q D S ++ + KL Q+ I+ + +E +K+E Q+
Sbjct: 2204 KQKELLIKIQHLQQDCDVPSRELR-DLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVL 2262
Query: 879 TNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEK----FQQEKEELINKKN 934
+N + Q E+ + +++ L I+ +++ + E E +
Sbjct: 2263 SNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSA 2322
Query: 935 TSNKIAQDKLNDIKEKVKNIHGYMKDIENYI----------QDGKDDYKKQKET------ 978
T +K + L +KEK + + + ++ + QD K+ + + T
Sbjct: 2323 TISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEK 2382
Query: 979 --ELNKVIAQLSECEKHKE----KINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELK 1032
EL + + E HKE K+ +++ + I K+Q + + N L K E ++
Sbjct: 2383 IRELENSLHEAKESAMHKESKIIKMQKELEVTNDII--AKLQAKVHESNKCLEKTKETIQ 2440
Query: 1033 EVEEE----RKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHF 1088
++++ K + +E+ +++ +K + +K+ +N ++ + A Y++E+I
Sbjct: 2441 VLQDKVALGAKPYKEEIEDLKMKLVKIDLEKM-KNAKEFEKEIS-ATKATVEYQKEVIRL 2498
Query: 1089 KKE-LREPQ 1096
+E LR Q
Sbjct: 2499 LRENLRRSQ 2507
Score = 102 bits (254), Expect = 2e-21
Identities = 185/913 (20%), Positives = 399/913 (43%), Gaps = 165/913 (18%)
Query: 315 VREKERKLVDCHRELEKLNKESRLLNQEK---SELLVEQGRLQLQADRHQEHIRARDSLI 371
++ ++++D ++LE+++ E+R EK ++LL E+ LQ + E++
Sbjct: 345 LKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTS 404
Query: 372 QSLATQLELDGFER-------GPFSERQIKNF--------------HK----LVRERQE- 405
SL Q EL + G ++ + N+ HK L+RE E
Sbjct: 405 SSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDES 464
Query: 406 --GEAKTANQLMNDFAEKE------TLKQKQID-EIRDKKTGLGRII----ELKSEILSK 452
E+ + ++ +E E L Q+ I+ E+ + ++ +L++E K
Sbjct: 465 VCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTE---K 521
Query: 453 KQNELK-NVKYELQQLEGSSDRILELDQE------------LIK--------AERELSK- 490
++ ELK K +L + E + +R + DQE L+K E ELS
Sbjct: 522 EEMELKLKEKNDLDEFE-ALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSK 580
Query: 491 ----AEKNSNVETLKMEVIS--LQNEKADLDRTLRKLD--QEMEQLNHHTTT-----RTQ 537
EK ++ L+ + S L+N K DL +L ++ ++M+Q T + +
Sbjct: 581 VELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRE 640
Query: 538 MEMLTKDKADKDEQIRKIKSRH---SDELTSLLGYFPNKKQ----LEDWLHSKSKEINQT 590
L + + E+++++ + + +++ KK+ LE L S EI +
Sbjct: 641 SAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKL 700
Query: 591 RDRL-AKLNKELASS---EQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLK 646
+ K+ K+L + E + EL ++ E+ + +++ + + S+++RL+
Sbjct: 701 TSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLR 760
Query: 647 EEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVIS------- 699
+EI+ S++ ++ T+ + +++ + + + + +T+ +L S
Sbjct: 761 KEIQDKSEELHII---TSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQ 817
Query: 700 ----------DLQSKLRLAPDKLKSTESE---LKKKEKRRDEMLGLVPMRQSIIDLKEKE 746
D + K ++ ++ + E L K+ ++ D LG + ++ + K +E
Sbjct: 818 EFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGAL---KTELSYKTQE 874
Query: 747 IPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEE----ESAKVCLTDVTIMERFQMEL 802
+ E ++Q ++++LK +E +++ L T+ E+ E + L +V + + + +L
Sbjct: 875 LQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDL 934
Query: 803 KDVERKIAQQAAKLQ-------GIDLDRTVQQVNQEKQEKQHK--LDTVSSKI--ELNRK 851
K ++ + + +L+ +++D Q N + KQH+ ++T+ SKI E++R
Sbjct: 935 KQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRN 994
Query: 852 LIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELST------EVQSLYREI 905
L H++ T E K E Q + ++Q LE + + T E+ R+I
Sbjct: 995 L---------HMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKI 1045
Query: 906 KDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYI 965
++ + L+ LE EKE+L T K + + +E+++ + +K + +
Sbjct: 1046 FSLIQEKNELQQMLESVIAEKEQL----KTDLKENIEMTIENQEELRLLGDELKKQQEIV 1101
Query: 966 QDGKDDYKKQKETELNKVIAQLSEC-EKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTL 1024
K ++ +KE EL++ +L+E EK KEK + +Q ++ Q ++ +
Sbjct: 1102 AQEK-NHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQ-------EEMSEM 1153
Query: 1025 RKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIK---RNHNLALGRQKGY 1081
+K+ E++ ++ E K + M+ +++ QKL EN + +K + + QK +
Sbjct: 1154 QKKINEIENLKNELKNKELTLEHMETERLELA-QKLNENYEEVKSITKERKVLKELQKSF 1212
Query: 1082 EEEIIHFKKELRE 1094
E E H + +RE
Sbjct: 1213 ETERDHLRGYIRE 1225
Score = 96.3 bits (238), Expect = 2e-19
Identities = 187/922 (20%), Positives = 405/922 (43%), Gaps = 132/922 (14%)
Query: 72 VAQETDVRAQIRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITRTKHGEKVSLSS 131
V+++TD + ++ + N +L + + K+ + + TL+ + T+ +KVS
Sbjct: 1797 VSEKTDKLSNMQKDLENSNAKL----QEKIQELKANEHQLITLKKDVNETQ--KKVSEME 1850
Query: 132 KCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKA-LE 190
+ + ++ SL +SK + N+ + N L E K++ ++ D + +K +
Sbjct: 1851 QLKKQIKDQ--SLTLSKLEIENLNLAQKLHEN--LEEMKSVMKERDNLRRVEETLKLERD 1906
Query: 191 TLRQVRQTQGQKVKEYQMELKYL----KQYKEKACEIRDQITSKEAQLTSSKEIVKSYEN 246
L++ Q + E Q ELK K++KE ++R++I+ K Q++ +I K +
Sbjct: 1907 QLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQIS---DIQKDLDK 1963
Query: 247 ELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLND 306
D L+ +++E++ +++++ ++ + +ME+ ++K F+ + +
Sbjct: 1964 SKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQ--------LKKQFEAQNLSMQS 2015
Query: 307 L-YHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIR 365
+ N Q T +KL H LE++ R++ +E+ EL + L+++ D
Sbjct: 2016 VRMDNFQLT-----KKL---HESLEEI----RIVAKERDELRRIKESLKMERD------- 2056
Query: 366 ARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLK 425
Q +AT E+ +R Q+K +L+ + Q+ ++ + + KE LK
Sbjct: 2057 ------QFIATLREMIARDR---QNHQVKPEKRLLSDGQQHLTESLREKCSRI--KELLK 2105
Query: 426 QKQIDEIRDKKTGLGRI-IELKSEILSKKQNELK-----NVKY----ELQQLEGSSDRI- 474
+ E+ D L R+ ++L+ EI +K+ ++ ++ Y +++L ++ R
Sbjct: 2106 R--YSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCS 2163
Query: 475 LELDQELIKAERELS-----KAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQ------ 523
+E + + K + LS K E++ ++ +M+ I ++ +L ++ L Q
Sbjct: 2164 MEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPS 2223
Query: 524 -EMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQ----LED 578
E+ L + +E + KD ++ + IK+ L+ N+K+ LE+
Sbjct: 2224 RELRDLKLNQNMDLHIEEILKDFSESE--FPSIKTEFQQVLS-------NRKEMTQFLEE 2274
Query: 579 WLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDF 638
WL+++ +I + ++ + K N + Q N NN + + + +E++ + S+++
Sbjct: 2275 WLNTRF-DIEKLKNGIQKENDRIC---QVNNFFNNRIIAIMNESTEFEERSATI--SKEW 2328
Query: 639 ESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVI 698
E DL LKE+ EK K L + A +Q + T +N++ V R Q E I
Sbjct: 2329 EQDLKSLKEKNEKLFKNYQTLKTSLASGAQ-VNPTTQDNKNP-HVTSRATQLTTEK---I 2383
Query: 699 SDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVN 758
+L++ L A + ES++ K +K +++ I +L+ K+ N
Sbjct: 2384 RELENSLHEAKESAMHKESKIIKMQKE--------------LEVTNDIIAKLQAKVHESN 2429
Query: 759 RDIQRLKNDIE--EQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKL 816
+ +++ K I+ + + LG +EE + + V I K+ E++I+ A +
Sbjct: 2430 KCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATV 2489
Query: 817 QGIDLDRTVQQVNQEKQEKQHKLDTVSSKIE---LNRKLIQDQQEQI-QHLKSTTNELKS 872
+ + + N + ++ +S + N+ L I Q+ K+ LKS
Sbjct: 2490 EYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALI--LKS 2547
Query: 873 EKLQISTNLQRRQQLEEQTVELSTEV----QSLYREIKDAKEQVSPLETTLEKFQQEKEE 928
E +++ + + +Q EQ ++ E+ Q L E+K KE+ E + + +
Sbjct: 2548 EHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPK 2607
Query: 929 LINKKNTSNKIAQDKLNDIKEK 950
T++K Q + KE+
Sbjct: 2608 SPKVTGTASKKKQITPSQCKER 2629
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 135 bits (341), Expect = 2e-31
Identities = 224/1130 (19%), Positives = 479/1130 (42%), Gaps = 197/1130 (17%)
Query: 125 EKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPL-----SEGKA-LKQKFDE 178
E ++ + +I E+ S K + ++ +E ++ L +EG A +++ D+
Sbjct: 854 EMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQ 913
Query: 179 IFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKAC-EIRDQITSKEAQLTSS 237
+ ++A +++V + + + +E EL K+ E C E++ I E L
Sbjct: 914 LIKTKIQLEA--KIKEVTE-RAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKV 970
Query: 238 KEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVF 297
++ + EN++ L + ++ ++K+ K E KAL +Q D E+K+ +
Sbjct: 971 EKEKHATENKVKNLTEEMAGLDETIAKLTK---EKKALQEAHQQTLDDLQAEEDKVNTLT 1027
Query: 298 QGT---DEQLNDLYHNHQRTVREKERKL-VDCHRELEKLNKESRLLNQEKSELLVEQGRL 353
+ ++Q++DL + E+E+KL +D R KL + +L ++S + +E +
Sbjct: 1028 KAKIKLEQQVDDLEGS-----LEQEKKLRMDLERAKRKLEGDLKLA--QESIMDIENEKQ 1080
Query: 354 QLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEG-EAKTAN 412
QL E ++ ++ I +L +++E D G +++IK + E +E EA+ A+
Sbjct: 1081 QLD-----EKLKKKEFEISNLQSKIE-DEQALGIQLQKKIKELQARIEELEEEIEAERAS 1134
Query: 413 QLMNDFAEKETLK-QKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQL---- 467
+ AEK+ ++++EI ++ G + E+ K++ E + ++ +L++
Sbjct: 1135 RAK---AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQH 1191
Query: 468 --------EGSSDRILELDQEL-----IKAERELSKAEKNSNVETLKMEVISLQNEKADL 514
+ +D + EL +++ +K + E K+E ++ L V ++ K +L
Sbjct: 1192 EATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNL 1251
Query: 515 DRTLRKLDQEMEQL-----------NHHTTTRTQMEMLTKD---KADKDEQIRKIKSRHS 560
++ R L+ ++ +L N T R +++ + + + D+ E + SR
Sbjct: 1252 EKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGK 1311
Query: 561 DELTSLLGYFPNKKQLEDWLHSKSK---EINQTRDRLAKLNKELASSEQNKNHINNELKR 617
T + K+QLE+ + +K+ + +R L ++ +++K + L +
Sbjct: 1312 QAFTQQIEEL--KRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSK 1369
Query: 618 KEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDEN 677
+++ + K +E+D + EE+E++ K+ A A + + +
Sbjct: 1370 ANTEVAQWRTK---------YETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAK---- 1416
Query: 678 QSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQ 737
C + +T+ LQ + DL L ++ + + L KK++ D++L +
Sbjct: 1417 ------CASLEKTKQRLQNEVEDLM----LDVERTNAACAALDKKQRNFDKILAEWKQK- 1465
Query: 738 SIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVT--IM 795
+ E+ + + +++ ++ ++KN EE L T+ E ++ + ++D+T I
Sbjct: 1466 --CEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIA 1523
Query: 796 ERFQM--ELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLI 853
E + EL+ +++++ Q+ +LQ + ++E + + +L+ K E++RK+
Sbjct: 1524 EGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIA 1583
Query: 854 QDQQEQ----------IQHLKSTTN-ELKSEKLQISTNLQRRQQLEEQTVELS------- 895
+ +E ++ ++ST + E++S I + L E ++L+
Sbjct: 1584 EKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAA 1643
Query: 896 -----------------TEVQSLYREIKDAKEQVSPLETTLEKFQQEKEEL---INKKNT 935
+ R +D KEQ++ +E Q E EEL + +
Sbjct: 1644 EALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTER 1703
Query: 936 SNKIAQDKLNDIKEKVKNIH---------------------GYMKDIENYIQDGKDDYKK 974
S KIA+ +L D E+V+ +H G M+DI ++ ++ KK
Sbjct: 1704 SRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKK 1763
Query: 975 ------QKETELNK---VIAQLSECEKHKEKINEDMRLMRQDIDT----------QKI-- 1013
EL K A L +K+ E+ +D++L + + QK+
Sbjct: 1764 AITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEA 1823
Query: 1014 ------------QERWLQDNLTLRKRNEELKEV----EEERKQHLKEMGQMQVLQMKSEH 1057
Q+R + LRK +KE+ EE+RK L+ + LQ K +
Sbjct: 1824 RVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKS 1883
Query: 1058 QKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREM 1107
K + + N NLA R+ +E E + ++ E Q K RE+
Sbjct: 1884 YKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREV 1933
Score = 128 bits (322), Expect = 3e-29
Identities = 182/837 (21%), Positives = 365/837 (43%), Gaps = 113/837 (13%)
Query: 394 KNFHKLVRERQEGEAKTAN---QLMNDFAEKETLK---QKQIDEIRDKKTGLGRIIELKS 447
+ F K+ E + EAK +++ EK L+ Q + + + D + ++I+ K
Sbjct: 860 EEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKI 919
Query: 448 EILSK------KQNELKNVKYELQQLEGS-SDRILELDQELIKAERELSKAEKNSNVETL 500
++ +K + + + + EL + D EL +++ E L+K EK +
Sbjct: 920 QLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 979
Query: 501 KMEVISLQNEKADLDRTLRKLDQEMEQLNH-HTTTRTQMEMLTKDKADKDEQIRKIKSRH 559
K++ +L E A LD T+ KL +E + L H T ++ + DK + K K +
Sbjct: 980 KVK--NLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQA----EEDKVNTLTKAKIKL 1033
Query: 560 SDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKE 619
++ L G +K+L L +++ L + + E K ++ +LK+KE
Sbjct: 1034 EQQVDDLEGSLEQEKKLRMDLERAKRKLEGD---LKLAQESIMDIENEKQQLDEKLKKKE 1090
Query: 620 EQLSSYEDKLFD--VCGSQ------DFESDLDRLKEEIE-------KSSKQRAMLAGATA 664
++S+ + K+ D G Q + ++ ++ L+EEIE K+ KQR+ L+
Sbjct: 1091 FEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELE 1150
Query: 665 VYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEK 724
S+ +L + + + + EAE Q++ DL+ A + ++T + L+KK
Sbjct: 1151 EISE---RLEEAGGATSAQIEMNKKREAEFQKMRRDLEE----ATLQHEATAATLRKKHA 1203
Query: 725 RRDEMLG-LVPMRQSIIDLKEKEIPELRNKLQNVNRDIQ---RLKNDIEEQ----ETLLG 776
LG + Q + EKE E++ ++ ++ +++ + K ++E+ E L
Sbjct: 1204 DSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLS 1263
Query: 777 TIMPEEESAKVCLTDVTIME--------RFQMELKDVERKIAQ-----QAAKLQGIDLDR 823
+ +EE + + D+T F +L + E ++Q QA Q +L R
Sbjct: 1264 ELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKR 1323
Query: 824 TVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTN--- 880
+++ + K H L + +L R+ +++QE L+ ++ +E Q T
Sbjct: 1324 QLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYET 1383
Query: 881 --LQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNK 938
+QR ++LEE +L+ +Q+ ++ + + LE T ++ Q E E+L+ +N
Sbjct: 1384 DAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNA 1443
Query: 939 --IAQDK--------LNDIKEKVKNIHGYMKDIENYIQD-GKDDYKKQKETELNKVIAQL 987
A DK L + K+K + H ++ + + G + +K + E + + QL
Sbjct: 1444 ACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYE--ESLDQL 1501
Query: 988 SECEKHKEKINEDMRLMRQDI--------DTQKIQERWLQDNLTLRKRNEELKEVEEERK 1039
++ + + +++ + + I + +KI+++ Q+ L+ EE + E +
Sbjct: 1502 ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEE 1561
Query: 1040 QHLKEMGQMQVLQMKSEHQK----LEENIDNIKRNH-NLALGRQKGYEEEI------IHF 1088
+ + Q+++ Q+KSE + +E ID +KRNH + Q + EI I
Sbjct: 1562 GKILRI-QLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL 1620
Query: 1089 KKELR------EPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMK 1139
KK++ E Q A E + R T+ + KD I+ LD A+ +K
Sbjct: 1621 KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIH---LDDALRSQEDLK 1674
Score = 82.4 bits (202), Expect = 3e-15
Identities = 103/512 (20%), Positives = 219/512 (42%), Gaps = 74/512 (14%)
Query: 595 AKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSK 654
A+ KE+A+ ++ I +EL + E + E+K+ + LKE+ + +
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTL------------LKEKNDLQLQ 896
Query: 655 QRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVIS------DLQSKLRLA 708
+A G L D + C + + Q EA+++EV ++ ++L
Sbjct: 897 VQAEAEG-----------LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAK 945
Query: 709 PDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDI 768
KL+ SELKK + L V + + K K + E L + + K +
Sbjct: 946 KRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKAL 1005
Query: 769 EE-QETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAA----------KLQ 817
+E + L + EE+ LT I + + ++ D+E + Q+ KL+
Sbjct: 1006 QEAHQQTLDDLQAEEDKVNT-LTKAKI--KLEQQVDDLEGSLEQEKKLRMDLERAKRKLE 1062
Query: 818 G---------IDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTN 868
G +D++ QQ++++ ++K+ ++ + SKIE + L Q++I+ L++
Sbjct: 1063 GDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIE 1122
Query: 869 ELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAK-------EQVSPLETTLEK 921
EL+ E I R + E+Q +LS E++ + +++A E E +K
Sbjct: 1123 ELEEE---IEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQK 1179
Query: 922 FQQEKEELINKKN----TSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKE 977
+++ EE + T K D + ++ E++ N+ + +E + K +
Sbjct: 1180 MRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK-----EKSEMKMEI 1234
Query: 978 TELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEE 1037
+L + +S+ + + EK+ + ++ +++ +++ L ++LT ++ + + E
Sbjct: 1235 DDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFS 1294
Query: 1038 RKQHLKEMGQMQVLQMKSEHQKLEENIDNIKR 1069
R+ KE V Q+ Q + I+ +KR
Sbjct: 1295 RQLDEKE---ALVSQLSRGKQAFTQQIEELKR 1323
Score = 66.6 bits (161), Expect = 1e-10
Identities = 118/595 (19%), Positives = 242/595 (40%), Gaps = 78/595 (13%)
Query: 201 QKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEH 260
Q+ +E + K L Q + A E + + +K A L +K+ + +NE++ L + ++E
Sbjct: 1387 QRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRL---QNEVEDL---MLDVER 1440
Query: 261 NLSKIMKLD----NEIKALDSRKKQMEKDNSELEE-------------KMEKVFQGTDEQ 303
+ LD N K L K++ E+ ++ELE K++ ++ + +Q
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ 1500
Query: 304 LNDLYH---NHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRH 360
L L N Q+ + + ++ + + + +L K + + QEK EL Q L+ +A+
Sbjct: 1501 LETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCEL---QAALE-EAEAS 1556
Query: 361 QEHIRARDSLIQSLATQLELDGFERGPFSER---QIKNFHKLVRERQEGEAKTANQLMND 417
EH + IQ Q++ + + + Q+K H + E + + ND
Sbjct: 1557 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRND 1616
Query: 418 FAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILEL 477
LK+K ++ + + L + +E L +N + L+ + D L
Sbjct: 1617 AIR---LKKKMEGDLNEMEIQLNHANRMAAEAL----RNYRNTQGILKDTQIHLDDALRS 1669
Query: 478 DQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTT-RT 536
++L + +L+ E+ +N+ L+ E+ L+ +R+ + +QE+ + T
Sbjct: 1670 QEDL---KEQLAMVERRANL--LQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHT 1724
Query: 537 QMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAK 596
Q L K + I +++ D L K+ ++E+ + +D A
Sbjct: 1725 QNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAH 1784
Query: 597 LNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQR 656
L + + EQ + L E+ K Q E+ + L+ E+E K+
Sbjct: 1785 LERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQI-----QKLEARVRELEGEVESEQKRN 1839
Query: 657 AMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAE------LQEVISDLQSKL----R 706
A + + + +LT +QTE + LQ+++ LQ+K+ R
Sbjct: 1840 AEAVKGLRKHERRVKELT-------------YQTEEDRKNILRLQDLVDKLQAKVKSYKR 1886
Query: 707 LAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDI 761
A + + + + L K K + E+ + D+ E ++ +LR K + V+ +
Sbjct: 1887 QAEEAEEQSNTNLAKFRKLQHEL----EEAEERADIAESQVNKLRVKSREVHTKV 1937
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 135 bits (341), Expect = 2e-31
Identities = 224/1130 (19%), Positives = 479/1130 (42%), Gaps = 197/1130 (17%)
Query: 125 EKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPL-----SEGKA-LKQKFDE 178
E ++ + +I E+ S K + ++ +E ++ L +EG A +++ D+
Sbjct: 854 EMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQ 913
Query: 179 IFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKAC-EIRDQITSKEAQLTSS 237
+ ++A +++V + + + +E EL K+ E C E++ I E L
Sbjct: 914 LIKTKIQLEA--KIKEVTE-RAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKV 970
Query: 238 KEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVF 297
++ + EN++ L + ++ ++K+ K E KAL +Q D E+K+ +
Sbjct: 971 EKEKHATENKVKNLTEEMAGLDETIAKLTK---EKKALQEAHQQTLDDLQAEEDKVNTLT 1027
Query: 298 QGT---DEQLNDLYHNHQRTVREKERKL-VDCHRELEKLNKESRLLNQEKSELLVEQGRL 353
+ ++Q++DL + E+E+KL +D R KL + +L ++S + +E +
Sbjct: 1028 KAKIKLEQQVDDLEGS-----LEQEKKLRMDLERAKRKLEGDLKLA--QESIMDIENEKQ 1080
Query: 354 QLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEG-EAKTAN 412
QL E ++ ++ I +L +++E D G +++IK + E +E EA+ A+
Sbjct: 1081 QLD-----EKLKKKEFEISNLQSKIE-DEQALGIQLQKKIKELQARIEELEEEIEAERAS 1134
Query: 413 QLMNDFAEKETLK-QKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQL---- 467
+ AEK+ ++++EI ++ G + E+ K++ E + ++ +L++
Sbjct: 1135 RAK---AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQH 1191
Query: 468 --------EGSSDRILELDQEL-----IKAERELSKAEKNSNVETLKMEVISLQNEKADL 514
+ +D + EL +++ +K + E K+E ++ L V ++ K +L
Sbjct: 1192 EATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNL 1251
Query: 515 DRTLRKLDQEMEQL-----------NHHTTTRTQMEMLTKD---KADKDEQIRKIKSRHS 560
++ R L+ ++ +L N T R +++ + + + D+ E + SR
Sbjct: 1252 EKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGK 1311
Query: 561 DELTSLLGYFPNKKQLEDWLHSKSK---EINQTRDRLAKLNKELASSEQNKNHINNELKR 617
T + K+QLE+ + +K+ + +R L ++ +++K + L +
Sbjct: 1312 QAFTQQIEEL--KRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSK 1369
Query: 618 KEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDEN 677
+++ + K +E+D + EE+E++ K+ A A + + +
Sbjct: 1370 ANTEVAQWRTK---------YETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAK---- 1416
Query: 678 QSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQ 737
C + +T+ LQ + DL L ++ + + L KK++ D++L +
Sbjct: 1417 ------CASLEKTKQRLQNEVEDLM----LDVERTNAACAALDKKQRNFDKILAEWKQK- 1465
Query: 738 SIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVT--IM 795
+ E+ + + +++ ++ ++KN EE L T+ E ++ + ++D+T I
Sbjct: 1466 --CEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIA 1523
Query: 796 ERFQM--ELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLI 853
E + EL+ +++++ Q+ +LQ + ++E + + +L+ K E++RK+
Sbjct: 1524 EGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIA 1583
Query: 854 QDQQEQ----------IQHLKSTTN-ELKSEKLQISTNLQRRQQLEEQTVELS------- 895
+ +E ++ ++ST + E++S I + L E ++L+
Sbjct: 1584 EKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAA 1643
Query: 896 -----------------TEVQSLYREIKDAKEQVSPLETTLEKFQQEKEEL---INKKNT 935
+ R +D KEQ++ +E Q E EEL + +
Sbjct: 1644 EALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTER 1703
Query: 936 SNKIAQDKLNDIKEKVKNIH---------------------GYMKDIENYIQDGKDDYKK 974
S KIA+ +L D E+V+ +H G M+DI ++ ++ KK
Sbjct: 1704 SRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKK 1763
Query: 975 ------QKETELNK---VIAQLSECEKHKEKINEDMRLMRQDIDT----------QKI-- 1013
EL K A L +K+ E+ +D++L + + QK+
Sbjct: 1764 AITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEA 1823
Query: 1014 ------------QERWLQDNLTLRKRNEELKEV----EEERKQHLKEMGQMQVLQMKSEH 1057
Q+R + LRK +KE+ EE+RK L+ + LQ K +
Sbjct: 1824 RVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKS 1883
Query: 1058 QKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREM 1107
K + + N NLA R+ +E E + ++ E Q K RE+
Sbjct: 1884 YKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREV 1933
Score = 128 bits (322), Expect = 3e-29
Identities = 182/837 (21%), Positives = 365/837 (43%), Gaps = 113/837 (13%)
Query: 394 KNFHKLVRERQEGEAKTAN---QLMNDFAEKETLK---QKQIDEIRDKKTGLGRIIELKS 447
+ F K+ E + EAK +++ EK L+ Q + + + D + ++I+ K
Sbjct: 860 EEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKI 919
Query: 448 EILSK------KQNELKNVKYELQQLEGS-SDRILELDQELIKAERELSKAEKNSNVETL 500
++ +K + + + + EL + D EL +++ E L+K EK +
Sbjct: 920 QLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 979
Query: 501 KMEVISLQNEKADLDRTLRKLDQEMEQLNH-HTTTRTQMEMLTKDKADKDEQIRKIKSRH 559
K++ +L E A LD T+ KL +E + L H T ++ + DK + K K +
Sbjct: 980 KVK--NLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQA----EEDKVNTLTKAKIKL 1033
Query: 560 SDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKE 619
++ L G +K+L L +++ L + + E K ++ +LK+KE
Sbjct: 1034 EQQVDDLEGSLEQEKKLRMDLERAKRKLEGD---LKLAQESIMDIENEKQQLDEKLKKKE 1090
Query: 620 EQLSSYEDKLFD--VCGSQ------DFESDLDRLKEEIE-------KSSKQRAMLAGATA 664
++S+ + K+ D G Q + ++ ++ L+EEIE K+ KQR+ L+
Sbjct: 1091 FEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELE 1150
Query: 665 VYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEK 724
S+ +L + + + + EAE Q++ DL+ A + ++T + L+KK
Sbjct: 1151 EISE---RLEEAGGATSAQIEMNKKREAEFQKMRRDLEE----ATLQHEATAATLRKKHA 1203
Query: 725 RRDEMLG-LVPMRQSIIDLKEKEIPELRNKLQNVNRDIQ---RLKNDIEEQ----ETLLG 776
LG + Q + EKE E++ ++ ++ +++ + K ++E+ E L
Sbjct: 1204 DSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLS 1263
Query: 777 TIMPEEESAKVCLTDVTIME--------RFQMELKDVERKIAQ-----QAAKLQGIDLDR 823
+ +EE + + D+T F +L + E ++Q QA Q +L R
Sbjct: 1264 ELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKR 1323
Query: 824 TVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTN--- 880
+++ + K H L + +L R+ +++QE L+ ++ +E Q T
Sbjct: 1324 QLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYET 1383
Query: 881 --LQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNK 938
+QR ++LEE +L+ +Q+ ++ + + LE T ++ Q E E+L+ +N
Sbjct: 1384 DAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNA 1443
Query: 939 --IAQDK--------LNDIKEKVKNIHGYMKDIENYIQD-GKDDYKKQKETELNKVIAQL 987
A DK L + K+K + H ++ + + G + +K + E + + QL
Sbjct: 1444 ACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYE--ESLDQL 1501
Query: 988 SECEKHKEKINEDMRLMRQDI--------DTQKIQERWLQDNLTLRKRNEELKEVEEERK 1039
++ + + +++ + + I + +KI+++ Q+ L+ EE + E +
Sbjct: 1502 ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEE 1561
Query: 1040 QHLKEMGQMQVLQMKSEHQK----LEENIDNIKRNH-NLALGRQKGYEEEI------IHF 1088
+ + Q+++ Q+KSE + +E ID +KRNH + Q + EI I
Sbjct: 1562 GKILRI-QLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL 1620
Query: 1089 KKELR------EPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMK 1139
KK++ E Q A E + R T+ + KD I+ LD A+ +K
Sbjct: 1621 KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIH---LDDALRSQEDLK 1674
Score = 82.4 bits (202), Expect = 3e-15
Identities = 103/512 (20%), Positives = 219/512 (42%), Gaps = 74/512 (14%)
Query: 595 AKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSK 654
A+ KE+A+ ++ I +EL + E + E+K+ + LKE+ + +
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTL------------LKEKNDLQLQ 896
Query: 655 QRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVIS------DLQSKLRLA 708
+A G L D + C + + Q EA+++EV ++ ++L
Sbjct: 897 VQAEAEG-----------LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAK 945
Query: 709 PDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDI 768
KL+ SELKK + L V + + K K + E L + + K +
Sbjct: 946 KRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKAL 1005
Query: 769 EE-QETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAA----------KLQ 817
+E + L + EE+ LT I + + ++ D+E + Q+ KL+
Sbjct: 1006 QEAHQQTLDDLQAEEDKVNT-LTKAKI--KLEQQVDDLEGSLEQEKKLRMDLERAKRKLE 1062
Query: 818 G---------IDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTN 868
G +D++ QQ++++ ++K+ ++ + SKIE + L Q++I+ L++
Sbjct: 1063 GDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIE 1122
Query: 869 ELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAK-------EQVSPLETTLEK 921
EL+ E I R + E+Q +LS E++ + +++A E E +K
Sbjct: 1123 ELEEE---IEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQK 1179
Query: 922 FQQEKEELINKKN----TSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKE 977
+++ EE + T K D + ++ E++ N+ + +E + K +
Sbjct: 1180 MRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK-----EKSEMKMEI 1234
Query: 978 TELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEE 1037
+L + +S+ + + EK+ + ++ +++ +++ L ++LT ++ + + E
Sbjct: 1235 DDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFS 1294
Query: 1038 RKQHLKEMGQMQVLQMKSEHQKLEENIDNIKR 1069
R+ KE V Q+ Q + I+ +KR
Sbjct: 1295 RQLDEKE---ALVSQLSRGKQAFTQQIEELKR 1323
Score = 66.6 bits (161), Expect = 1e-10
Identities = 118/595 (19%), Positives = 242/595 (40%), Gaps = 78/595 (13%)
Query: 201 QKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEH 260
Q+ +E + K L Q + A E + + +K A L +K+ + +NE++ L + ++E
Sbjct: 1387 QRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRL---QNEVEDL---MLDVER 1440
Query: 261 NLSKIMKLD----NEIKALDSRKKQMEKDNSELEE-------------KMEKVFQGTDEQ 303
+ LD N K L K++ E+ ++ELE K++ ++ + +Q
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ 1500
Query: 304 LNDLYH---NHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRH 360
L L N Q+ + + ++ + + + +L K + + QEK EL Q L+ +A+
Sbjct: 1501 LETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCEL---QAALE-EAEAS 1556
Query: 361 QEHIRARDSLIQSLATQLELDGFERGPFSER---QIKNFHKLVRERQEGEAKTANQLMND 417
EH + IQ Q++ + + + Q+K H + E + + ND
Sbjct: 1557 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRND 1616
Query: 418 FAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILEL 477
LK+K ++ + + L + +E L +N + L+ + D L
Sbjct: 1617 AIR---LKKKMEGDLNEMEIQLNHANRMAAEAL----RNYRNTQGILKDTQIHLDDALRS 1669
Query: 478 DQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTT-RT 536
++L + +L+ E+ +N+ L+ E+ L+ +R+ + +QE+ + T
Sbjct: 1670 QEDL---KEQLAMVERRANL--LQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHT 1724
Query: 537 QMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAK 596
Q L K + I +++ D L K+ ++E+ + +D A
Sbjct: 1725 QNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAH 1784
Query: 597 LNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQR 656
L + + EQ + L E+ K Q E+ + L+ E+E K+
Sbjct: 1785 LERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQI-----QKLEARVRELEGEVESEQKRN 1839
Query: 657 AMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAE------LQEVISDLQSKL----R 706
A + + + +LT +QTE + LQ+++ LQ+K+ R
Sbjct: 1840 AEAVKGLRKHERRVKELT-------------YQTEEDRKNILRLQDLVDKLQAKVKSYKR 1886
Query: 707 LAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDI 761
A + + + + L K K + E+ + D+ E ++ +LR K + V+ +
Sbjct: 1887 QAEEAEEQSNTNLAKFRKLQHEL----EEAEERADIAESQVNKLRVKSREVHTKV 1937
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 134 bits (338), Expect = 4e-31
Identities = 195/988 (19%), Positives = 440/988 (44%), Gaps = 113/988 (11%)
Query: 223 IRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSK-----------IMKLDNE 271
+RDQ+ E +LT ++ EL L+ +L + + SK +M+L
Sbjct: 1262 LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHET 1321
Query: 272 IKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKL--------- 322
+ +L SR ++ E E + + E + Q E L + Q V E +
Sbjct: 1322 MASLQSRLRRAELQRMEAQGERE-LLQAAKENLTAQVEHLQAAVVEARAQASAAGILEED 1380
Query: 323 VDCHRELEKLNKESRLLNQEKSELLVEQGRLQL-QADRHQEHIRARDSLIQSLATQLELD 381
+ R KL E +E+++ L EQG L++ Q QE++ L Q+LA + E
Sbjct: 1381 LRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLAL---LTQTLAEREEEV 1437
Query: 382 GFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGR 441
RG E + + RE Q+ + + + ++ L+Q+QI E+ ++
Sbjct: 1438 ETLRGQIQELEKQ------REMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRS---- 1487
Query: 442 IIELKSEILSKKQNELKNVKYELQQLEGSSDRILE---LDQELIKAERELSKAE-KNSNV 497
++E + +++ +L + ++++LE DR + L+ +L++ E++ E + V
Sbjct: 1488 VLEHLPMAVQEREQKLTVQREQIRELE--KDRETQRNVLEHQLLELEKKDQMIESQRGQV 1545
Query: 498 ETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTR-TQMEMLTKDKADKDEQIRKIK 556
+ LK ++++L+ +L+ K++ + + + R TQ LT D +E+ ++++
Sbjct: 1546 QDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQ 1605
Query: 557 SRHSD--ELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNE 614
++ S +L S + L L + +E+ R+++ +L ++ Q+ + E
Sbjct: 1606 AQSSQIHDLES------HSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQE 1659
Query: 615 LKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLT 674
L ++E++ ED+ ++ E DL+++K + + ++ Q + +
Sbjct: 1660 LMLQKERIQVLEDQR--TRQTKILEEDLEQIKLSLRERGRE-------LTTQRQLMQERA 1710
Query: 675 DENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVP 734
+E + + + ++ ++ D + ++ + + + + E++ + V
Sbjct: 1711 EEGKGPSKAQRGSLE---HMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVG 1767
Query: 735 MRQSIIDLKEKEIPELRNKLQNVNRD----IQRLKNDIEEQETLLGTIMPEEESAKVCLT 790
++ +E+EI L+ +LQ Q L++ ++E + L E E+
Sbjct: 1768 ETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEA------ 1821
Query: 791 DVTIMERFQMELKDVERKIAQQAAKLQGI--DLDRTVQQVNQEKQEKQHKLDTVSSKIEL 848
+++ Q + + E ++ ++A LQG T+++ + E Q+ + + + ++ +
Sbjct: 1822 ----LQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAV 1877
Query: 849 NRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDA 908
+ +Q +E + L++ + E + L + +QQ EQ E E ++L A
Sbjct: 1878 EGRRVQALEEVLGDLRAESREQEKALLAL------QQQCAEQAQEHEVETRALQDSWLQA 1931
Query: 909 KEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDG 968
+ + + LE + E + +++ A+ + ++E + H ++ E ++ +
Sbjct: 1932 QAVLKERDQELEALRAESQSSRHQEEA----ARARAEALQEALGKAHAALQGKEQHLLE- 1986
Query: 969 KDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKI--QERWLQDNLTLRK 1026
+ + + E + A L C+ H ++ E +R+ +I Q + QE Q L +
Sbjct: 1987 QAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQ 2046
Query: 1027 RNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEII 1086
R+EEL+ ++ER+Q L+ KS Q+++EN+ K+N LG+++ EEEI
Sbjct: 2047 RDEELRH-QQEREQLLE----------KSLAQRVQENMIQEKQN----LGQER-EEEEIR 2090
Query: 1087 HFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEIN-K 1145
+ +RE Q A+++ + ++ +R T+ N +L+ + + M+ S+K++ + +
Sbjct: 2091 GLHQSVRELQLTLAQKE--QEILELRETQQRN-NLEALPHSHKTSPMEEQSLKLDSLEPR 2147
Query: 1146 IIRDLWR--STYRGQDIEYIEIRSDADE 1171
+ R+L R + R + IE R A +
Sbjct: 2148 LQRELERLQAALRQTEAREIEWREKAQD 2175
Score = 125 bits (314), Expect = 3e-28
Identities = 264/1436 (18%), Positives = 592/1436 (41%), Gaps = 234/1436 (16%)
Query: 69 DPKVAQETDVRAQIRLQFRDVNGELIAVQRSMVCTQKSKKT----------EFKTLEGVI 118
+ ++ + + A+++ RD+ E +Q+ + ++ ++ E K E V+
Sbjct: 665 EAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVL 724
Query: 119 TRTKHGEKVSLSSKCA--------EIDR----EMISSLGVSKAVLNNVIF-CHQEDSNWP 165
R ++ + K A E DR E + L +K +L + +F Q++S
Sbjct: 725 ARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIE 784
Query: 166 LSEGKALKQKFDEIFSATRYI----KALETLRQVRQTQGQKVKEYQM-ELKYLKQYKEKA 220
+++G+ L+ + + A I + L+ ++Q ++ ++ +L +Q + A
Sbjct: 785 VTKGQ-LEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTA 843
Query: 221 CEIRDQITSKEA-QLTSSKEIVKSYENELDPLKNRLKEIEHNLSKI-MKLDNEIKALDSR 278
E + KE QL E +S+ + L L+ +E ++ M+L + +++
Sbjct: 844 LEQQKAAHEKEVNQLREKWEKERSWHQQ--ELAKALESLEREKMELEMRLKEQQTEMEAI 901
Query: 279 KKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRL 338
+ Q E++ ++ E + ++ T+++ L T+ + +++L D ++LE+L ++ ++
Sbjct: 902 QAQREEERTQAESALCQMQLETEKERVSLLE----TLLQTQKELADASQQLERLRQDMKV 957
Query: 339 LNQEKSELLVEQGRLQLQADRHQEHIRA-----RDSL--IQSLATQLELDGFERGPFSER 391
++ E G LQ Q Q ++ RD L +Q ++ L D + ++
Sbjct: 958 QKLKEQETT---GILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDL----QK 1010
Query: 392 QIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEIL- 450
Q+++ + + + + ++ E + + Q + R+K + ++E + +L
Sbjct: 1011 QVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLV 1070
Query: 451 -----SKKQNELKNVKYELQQLEGSSDRI---LELDQELIKAERELSKAEKNSNVETLKM 502
S +Q EL ++ ++Q+ +G + +EL ++ +K + A++ +E L+
Sbjct: 1071 LQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEA 1130
Query: 503 EVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDE------------ 550
I+ Q +A L K Q +L +T +Q+E L ++ ++
Sbjct: 1131 SHITEQQLRASLWAQEAKAAQLQLRLR---STESQLEALAAEQQPGNQAQAQAQLASLYS 1187
Query: 551 ----------QIRKIKSRHSDELTSLLGYFPNK------------------KQLEDWLHS 582
+ R S D S+ G P++ + + LH
Sbjct: 1188 ALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHK 1247
Query: 583 KSKEINQT-------RDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGS 635
+++ +T RD++ KL + L +E K+ ++ EL+ + QLS +++ G
Sbjct: 1248 LHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGK 1307
Query: 636 QD-FESDLDRLKEEIE--KSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEA 692
Q+ ES+L L E + +S +RA L A + + Q EN + + EA
Sbjct: 1308 QNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEA 1367
Query: 693 ELQEVISD-LQSKLRLAPDKLKSTESELKKKEKRRDEML---------------GLVPMR 736
Q + L+ LR A LK E++ + +R + L +
Sbjct: 1368 RAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLT 1427
Query: 737 QSIIDLKEKEIPELRNKLQNVNRD-------IQRLKNDIEEQETLLGTIMPEEESAKVCL 789
Q++ + +E+E+ LR ++Q + + ++ L D++++ + + + + C
Sbjct: 1428 QTLAE-REEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCR 1486
Query: 790 TDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQ----EKQHK------- 838
+ ++E M +++ E+K+ Q +++ ++ DR Q+ E Q EK+ +
Sbjct: 1487 S---VLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRG 1543
Query: 839 -----------LDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQ- 886
L+ ++ ++E N ++ QQ+ I+ L+ + ++ +L+ R Q
Sbjct: 1544 QVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQE 1603
Query: 887 ----------LEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEE-------- 928
LE + L+ E+Q +E+K +EQ+ L+ E Q+ E
Sbjct: 1604 LQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQ 1663
Query: 929 ------LINKKNTSNKIAQDKLNDIK----EKVKNIHGYMKDIENYIQDGKDDYKKQK-E 977
L +++ KI ++ L IK E+ + + + ++ ++GK K Q+
Sbjct: 1664 KERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGS 1723
Query: 978 TELNKVIA--QLSECEKHKEKINEDMRLMRQ-DIDTQKIQERWLQDNLTLRKRNEEL--- 1031
E K+I + E E +E I+E L Q + Q + + + +L L +R +E+
Sbjct: 1724 LEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVL 1783
Query: 1032 -KEVEEERKQ-HLKEMG-QMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEE----- 1083
++++E R+Q LKE Q Q+ + + + ++ ++ +++ A G+++ +E
Sbjct: 1784 QQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADAL 1843
Query: 1084 ----EIIHFKKELREPQFRDAEEKYR----EMMIVMRTTELVNK---DLDIYYKTLDQAI 1132
E H + R + +D +E+ R E+ + R + + + DL + ++A+
Sbjct: 1844 QGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKAL 1903
Query: 1133 MKFHSMKMEEI------NKIIRDLWRSTY-----RGQDIEYIEIRSDADENVSASDKRRN 1181
+ E+ + ++D W R Q++E + S + + + + R
Sbjct: 1904 LALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARA 1963
Query: 1182 YNYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGIIALDEPTTNLDREN 1241
+ + K AL + + Q L+ R A T L + A + L+
Sbjct: 1964 EALQEALGKAHAALQGKEQHLLEQAELS----RSLEASTATLQASLDACQAHSRQLEEAL 2019
Query: 1242 IESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEK--FYRIKKNIDQ 1295
+ ++ + + Q + DE+ R + +EK R+++N+ Q
Sbjct: 2020 RIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQ 2075
Score = 121 bits (304), Expect = 4e-27
Identities = 205/1055 (19%), Positives = 428/1055 (40%), Gaps = 171/1055 (16%)
Query: 190 ETLRQVRQTQGQKVKEYQMELKYLKQYKEKAC----EIRDQITSKEAQLTSSKEIVKSY- 244
E+L +V +++ + K L++ EK RD++ KE+Q +E K Y
Sbjct: 111 ESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYL 170
Query: 245 ENELDPLKNRLKEI----EHNLSKIMKLDN---EIKA----------------------- 274
+ E L + +E+ H L D E+KA
Sbjct: 171 KGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSR 230
Query: 275 -------LDSRK-----------KQMEKDNSELEEKMEKVFQGTD---EQLNDLYHNHQR 313
+D R+ +++EK+ E +++ ++ D +L D
Sbjct: 231 EPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSA 290
Query: 314 TVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQS 373
+ + +++ D + ++ L + +L +EL+ + L A QE + +I+
Sbjct: 291 LLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNA---QEEKLSLQQVIKD 347
Query: 374 LATQL--ELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDE 431
+ + E D +G E ++ + + +A A L+ T +++ + +
Sbjct: 348 ITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVL---TRRRQAVQD 404
Query: 432 IRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKA 491
+R + G + L + + + E K ++ LQ+L G D + +L
Sbjct: 405 LRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDL---------- 454
Query: 492 EKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQ 551
V++L E LQ + +L + L L+QE +L R +E+ + + + +
Sbjct: 455 --QGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLR-----RVNVELQLQGDSAQGQ- 506
Query: 552 IRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHI 611
K +EL + +++L++ L + +++ L L + L SS H+
Sbjct: 507 ----KEEQQEELHLAV---RERERLQEMLMGLEAKQSESLSELITLREALESS-----HL 554
Query: 612 NNELKRKEE-----QLSSYEDKLFDVCGSQD-FESDLDRLKEEIEKSSKQRAMLAGATAV 665
EL R+E+ L+ E + ++ S++ ++++ L+ K S LA
Sbjct: 555 EGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVG 614
Query: 666 YSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKR 725
+Q + QL +ENQS C + Q LQ +++ + + +K E++L+K E+
Sbjct: 615 LNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEA 674
Query: 726 RDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESA 785
E+ + Q + +K++ E R++ + +++L + + QE +L + E+E+
Sbjct: 675 GAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEAL 734
Query: 786 KVCLTDVTIMERFQMELKDVERKIAQQAAKLQGI-------------------------- 819
V ++ L+ VER A +LQG+
Sbjct: 735 ------VREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKG 788
Query: 820 DLDRTVQQVNQEKQEKQH-------KLDTVSSKIELN-----RKLIQDQQEQIQHLKSTT 867
L+ +Q V Q K+ Q +LDT S+ E R+L Q +QE L+
Sbjct: 789 QLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQK 848
Query: 868 NELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKE 927
+ E Q+ ++ + +Q EL+ ++SL RE + + ++ +T +E Q ++E
Sbjct: 849 AAHEKEVNQLREKWEKERSWHQQ--ELAKALESLEREKMELEMRLKEQQTEMEAIQAQRE 906
Query: 928 ELINKKNTSNKIAQDKLNDIKEKVKNIHGYMK------DIENYIQDGKDDYKKQKETELN 981
E + + + Q +L KE+V + ++ D ++ + D K QK E
Sbjct: 907 E--ERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQE 964
Query: 982 KVIAQLSECEKHKEKINEDMRLMRQDIDT-QKIQERWLQDNLTLRKRNEELKE--VEEER 1038
++ ++ + ++ E R R D+ Q+ LQD + L+K+ E+LK V ++
Sbjct: 965 TTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDD 1024
Query: 1039 KQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKG-----------YEEEIIH 1087
Q L E + L+ E+ ++++ ++ K + L+L ++ ++E+
Sbjct: 1025 SQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSA 1084
Query: 1088 FKKELREPQFRDAEEKYREMMIVMRTTELVNKDLD 1122
+++++E Q E+K + + E+ K+ D
Sbjct: 1085 LRQDMQEAQ---GEQKELSAQMELLRQEVKEKEAD 1116
Score = 111 bits (277), Expect = 5e-24
Identities = 191/938 (20%), Positives = 393/938 (41%), Gaps = 103/938 (10%)
Query: 228 TSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNS 287
T EAQL ++E + +L ++ +EI+ LS+ ++ +A ++ +Q+ ++
Sbjct: 662 THLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESR---HQQEAATTQLEQLHQEAK 718
Query: 288 ELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLL-------N 340
EE + + Q + + + R ++ ER D +L+ L+ LL
Sbjct: 719 RQEEVLARAVQEKEALVREKAALEVR-LQAVERDRQDLAEQLQGLSSAKELLESSLFEAQ 777
Query: 341 QEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLV 400
Q+ S + V +G+L++Q + ++ L +LELD ER + + +L
Sbjct: 778 QQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCL--KLELD-TERSQAEQERDAAARQLA 834
Query: 401 RERQEGEA----------KTANQLMNDFAEKETLKQKQIDEI-----RDKKTGLGRIIEL 445
+ QEG+ K NQL + ++ + Q+++ + R+K R+ E
Sbjct: 835 QAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQ 894
Query: 446 KSE---ILSKKQNELKNVKYEL--QQLEGSSDRI------LELDQELIKAERELSKAEKN 494
++E I ++++ E + L QLE +R+ L+ +EL A ++L + ++
Sbjct: 895 QTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQD 954
Query: 495 SNVETLKMEVIS------LQNEKADLDRTLRKLDQEMEQLNHHTTT--------RTQMEM 540
V+ LK + + LQ + +L R+ ++ L +++ + Q+E
Sbjct: 955 MKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVED 1014
Query: 541 LTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKL--- 597
L +D+ R ++ ++L Y +K+LE S + + + RL L
Sbjct: 1015 LKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEA 1074
Query: 598 ----NKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKS- 652
+EL++ Q+ E K Q+ ++ + DF + +L EE+E S
Sbjct: 1075 DSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKE--KEADFLAQEAQLLEELEASH 1132
Query: 653 ---SKQRAMLAGATAVYSQFITQL-TDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLA 708
+ RA L A +Q +L + E+Q ++ +A+ Q ++ L S L+ A
Sbjct: 1133 ITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQA 1192
Query: 709 PDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDI 768
+ + EL + GL P + L ++ + V + +L D+
Sbjct: 1193 LGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDL 1252
Query: 769 EEQETLLGTIMPEEESAKVCLTDVTIMERFQM--ELKDVERKIAQ-QAAKLQGIDLDRTV 825
+ + + + + + LTD T E+ Q+ EL+D++R+++Q Q K + ++
Sbjct: 1253 WKTQQTRDVLRDQVQKLEERLTD-TEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSL 1311
Query: 826 QQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQE-----------QIQHLKSTTNELKSEK 874
+ E E L + + EL R Q ++E Q++HL++ E +++
Sbjct: 1312 ESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQ- 1370
Query: 875 LQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKN 934
+ L+ + ++L E RE A ++ L+ K QE L+ +
Sbjct: 1371 ASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQ-- 1428
Query: 935 TSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGK--------DDYKKQKETEL-NKVIA 985
L + +E+V+ + G ++++E + K D K+ +E +L + I
Sbjct: 1429 --------TLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480
Query: 986 QLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEM 1045
+L +C E + ++ Q + Q+ Q R L+ + ++ E + +E E+K + E
Sbjct: 1481 ELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIES 1540
Query: 1046 GQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEE 1083
+ QV +K + LE ++ NH+ +QK +E
Sbjct: 1541 QRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKE 1578
Score = 100 bits (248), Expect = 1e-20
Identities = 177/937 (18%), Positives = 379/937 (40%), Gaps = 113/937 (12%)
Query: 271 EIKALDSRKKQMEKDNSELEEKMEKVFQGTD---EQLNDLYHNHQRTVREKERKLVDCHR 327
++ L ++ +++EK+ E +++ ++ D +L D + + +++ D +
Sbjct: 245 QLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEK 304
Query: 328 ELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQL--ELDGFER 385
++ L + +L +EL+ + L A QE + +I+ + + E D +
Sbjct: 305 MIKALRETVEILETNHTELMEHEASLSRNA---QEEKLSLQQVIKDITQVMVEEGDNIAQ 361
Query: 386 GPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIEL 445
G E ++ + + +A A L+ T +++ + ++R + G + L
Sbjct: 362 GSGHENSLELDSSIFSQFDYQDADKALTLVRSVL---TRRRQAVQDLRQQLAGCQEAVNL 418
Query: 446 KSEILSKKQNELKNVKYELQQLEGSSDRI------LELDQELIKAEREL---SKAEKNSN 496
+ + + E K ++ LQ+L G D + L+ + + + EREL ++ E
Sbjct: 419 LQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQ 478
Query: 497 VETLKMEVISLQNEKADL----DRTLRKLDQEMEQLNHHTTTRTQM-EMLTKDKADKDEQ 551
+E L+ E L+ +L D + +++ E+L+ R ++ EML +A + E
Sbjct: 479 LEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSES 538
Query: 552 IRK-IKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNH 610
+ + I R + E + L G + L + E+ R + EL+SSE
Sbjct: 539 LSELITLREALESSHLEG---------ELLRQEQTEVTAALARAEQSIAELSSSENTLKT 589
Query: 611 INNELKRKEEQLSSYEDKL-FDVCGSQD----FESDLDRLKEEIEKSSKQRAMLAGATAV 665
+L+ +LS+ + L D G E + + +E + + R L A
Sbjct: 590 EVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAE 649
Query: 666 YSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTE--------- 716
+ L ++N Q+ + AELQ + D+Q + KL +
Sbjct: 650 AEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQ 709
Query: 717 -SELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIE----EQ 771
+L ++ KR++E+L + + ++EK E+R LQ V RD Q L ++ +
Sbjct: 710 LEQLHQEAKRQEEVLARAVQEKEAL-VREKAALEVR--LQAVERDRQDLAEQLQGLSSAK 766
Query: 772 ETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQE 831
E L ++ ++ V +E Q++ +++ Q + ++LD Q QE
Sbjct: 767 ELLESSLFEAQQQNSVIEVTKGQLE-VQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQE 825
Query: 832 KQE----------------KQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKL 875
+ +Q K +L K +++ Q L L+ EK+
Sbjct: 826 RDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKM 885
Query: 876 QISTNLQRRQ--------------------------QLEEQTVELSTEVQSLYREIKDAK 909
++ L+ +Q + E++ V L + +E+ DA
Sbjct: 886 ELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADAS 945
Query: 910 EQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGK 969
+Q+ L ++ + +++E T + AQ +L + + ++ +++ + + K
Sbjct: 946 QQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDK 1005
Query: 970 DDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNE 1029
D +KQ E ++++AQ ++++ E +R ++ QK ER + +LTL +
Sbjct: 1006 MDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELER-EKASLTLSLMEK 1064
Query: 1030 E-----LKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHN------LALGRQ 1078
E L+E + R+Q L + Q + + + E ++L ++ +++ LA Q
Sbjct: 1065 EQRLLVLQEADSIRQQELSALRQ-DMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQ 1123
Query: 1079 KGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTE 1115
E E H ++ E K ++ + +R+TE
Sbjct: 1124 LLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTE 1160
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 134 bits (338), Expect = 4e-31
Identities = 204/1065 (19%), Positives = 434/1065 (40%), Gaps = 182/1065 (17%)
Query: 202 KVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENEL--------DPLKN 253
K E + E+ +K+ EK E + +K +L + +N+L D L +
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLAD 904
Query: 254 RLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQR 313
+ + + ++L+ +IK + R + E+ N+EL K K+ E D+ + +
Sbjct: 905 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI-DDLEL 963
Query: 314 TVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQS 373
T+ + E++ +++ L +E L++ ++L E+ LQ + + ++A + + +
Sbjct: 964 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1023
Query: 374 LAT-----QLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQ 428
L + ++D E E++I+ + + + EG+ K A + D + ++
Sbjct: 1024 LTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEK 1083
Query: 429 IDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAER-E 487
+ + + +GL IE + + + Q ++K ++ +++LE E I+AER
Sbjct: 1084 LKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELE-----------EEIEAERAS 1132
Query: 488 LSKAEKNSNVETLKMEVISLQ--------------NEKADLDRTLRKLDQEMEQLNHHTT 533
+KAEK + + ++E IS + N+K + + + D E L H T
Sbjct: 1133 RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEAT 1192
Query: 534 TRTQMEMLTKDKADKDEQI---RKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQT 590
T + A+ EQI +++K + E + + K +++D L S + +++
Sbjct: 1193 AATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEM------KMEIDD-LASNMETVSKA 1245
Query: 591 RDRLAKLNK-------ELASSEQNKNHINNELKRKEEQLSS----YEDKLFD-------- 631
+ L K+ + E+ + E+ + + N+L + +L + Y +L +
Sbjct: 1246 KGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQL 1305
Query: 632 VCGSQDFESDLDRLKEEIEKSSKQRAMLAGA---TAVYSQFITQLTDENQSCCPVCQRV- 687
G Q F ++ LK ++E+ K ++ LA A + + + +E Q QR
Sbjct: 1306 SRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAM 1365
Query: 688 -------------FQTEA-----ELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEM 729
++T+A EL+E L +L+ A + +++ ++ EK + +
Sbjct: 1366 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRL 1425
Query: 730 LGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKV-- 787
V ++ L K +N ++ + K EE L E S
Sbjct: 1426 QNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTEL 1485
Query: 788 ---------CLTDVTIMER----FQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQE 834
L + ++R Q E+ D+ +IA+ ++ +L++ +QV QEK E
Sbjct: 1486 FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIH--ELEKIKKQVEQEKSE 1543
Query: 835 KQHKLDTVSS-------------------KIELNRKLIQDQQE----------QIQHLKS 865
Q L+ + K E++RK+ + +E ++ ++S
Sbjct: 1544 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQS 1603
Query: 866 TTN-ELKSEKLQISTNLQRRQQLEEQTVELS------------------------TEVQS 900
T + E++S I + L E ++L+ +
Sbjct: 1604 TLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDD 1663
Query: 901 LYREIKDAKEQVSPLETTLEKFQQEKEEL---INKKNTSNKIAQDKLNDIKEKVKNIHGY 957
R +D KEQ++ +E Q E EEL + + S KIA+ +L D E+V+ +H
Sbjct: 1664 ALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQ 1723
Query: 958 MKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERW 1017
+ N + + D Q + E+ +I + E+ +K D +M +++ ++
Sbjct: 1724 NTSLINTKKKLETDI-SQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQ----- 1777
Query: 1018 LQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGR 1077
+ L + + L++ ++ + L E Q+ + K + QKLE + ++ G
Sbjct: 1778 -DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELE-------GE 1829
Query: 1078 QKGYEEEIIHFKKELREPQFRDAEEKYR---EMMIVMRTTELVNK 1119
+ ++ + K LR+ + + E Y+ + ++R +LV+K
Sbjct: 1830 VESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDK 1874
Score = 132 bits (333), Expect = 2e-30
Identities = 204/1073 (19%), Positives = 460/1073 (42%), Gaps = 196/1073 (18%)
Query: 190 ETLRQVRQTQGQKVK-EYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENEL 248
++L + Q +K + Q+E K +K+ E+A E ++I A+LT+ K + E+E
Sbjct: 900 DSLADAEERCDQLIKTKIQLEAK-IKEVTERA-EDEEEIN---AELTAKK---RKLEDEC 951
Query: 249 DPLKNRLKEIEHNLSKIMK----LDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQL 304
LK + ++E L+K+ K +N++K L +++ ++L ++ + + + + L
Sbjct: 952 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTL 1011
Query: 305 NDLYHNHQRTVR------EKERKLVDCHRELEKLNKESRLLNQEKSEL-----LVEQGRL 353
+DL + + E+++ D LE+ K L + K +L L ++ +
Sbjct: 1012 DDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTM 1071
Query: 354 QLQADRHQ--EHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEG-EAKT 410
++ D+ Q E ++ ++ + L +++E D G +++IK + E +E EA+
Sbjct: 1072 DIENDKQQLDEKLKKKEFEMSGLQSKIE-DEQALGMQLQKKIKELQARIEELEEEIEAER 1130
Query: 411 ANQLMNDFAEKETLK-QKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQL-- 467
A++ AEK+ ++++EI ++ G + E+ K++ E + ++ +L++
Sbjct: 1131 ASRAK---AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL 1187
Query: 468 ----------EGSSDRILELDQEL-----IKAERELSKAEKNSNVETLKMEVISLQNEKA 512
+ +D + EL +++ +K + E K+E ++ L + ++ K
Sbjct: 1188 QHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKG 1247
Query: 513 DLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIK---SRHSDELTSLLGY 569
+L++ R L+ ++ ++ T + + L D + +++ SR DE +L+
Sbjct: 1248 NLEKMCRALEDQLSEIK---TKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQ 1304
Query: 570 FPN------------KKQLEDWLHSKSK---EINQTRDRLAKLNKELASSEQNKNHINNE 614
K+QLE+ + +KS + +R L ++ ++ K +
Sbjct: 1305 LSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRA 1364
Query: 615 LKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLT 674
+ + +++ + K +E+D + EE+E++ K+ A Q +
Sbjct: 1365 MSKANSEVAQWRTK---------YETDAIQRTEELEEAKKKLA----------QRLQDAE 1405
Query: 675 DENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVP 734
+ ++ C + +T+ LQ + DL + ++ + + L KK++ D++L
Sbjct: 1406 EHVEAVNAKCASLEKTKQRLQNEVEDLMIDV----ERTNAACAALDKKQRNFDKILAEWK 1461
Query: 735 MRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVT- 793
+ + E+ + + ++++ ++ ++KN EE L T+ E ++ + ++D+T
Sbjct: 1462 QK---CEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE 1518
Query: 794 -IMERFQM--ELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNR 850
I E + EL+ +++++ Q+ ++LQ + ++E + + +L+ K E++R
Sbjct: 1519 QIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1578
Query: 851 KLIQDQQEQ----------IQHLKSTTN-ELKSEKLQISTNLQRRQQLEEQTVELS---- 895
K+ + +E ++ ++ST + E++S I + L E ++L+
Sbjct: 1579 KIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANR 1638
Query: 896 --------------------TEVQSLYREIKDAKEQVSPLETTLEKFQQEKEEL---INK 932
+ R +D KEQ++ +E Q E EEL + +
Sbjct: 1639 MAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQ 1698
Query: 933 KNTSNKIAQDKLNDIKEKVKNIHGY------------------MKDIENYIQDGKDDYKK 974
S KIA+ +L D E+V+ +H ++E+ IQ+ ++ +K
Sbjct: 1699 TERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEK 1758
Query: 975 QKET---------ELNKVIAQLSECEKHKEKINEDMRLMRQDIDT-------------QK 1012
K+ EL K + E+ K+ + + ++ ++ +D QK
Sbjct: 1759 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK 1818
Query: 1013 I--------------QERWLQDNLTLRKRNEELKEV----EEERKQHLKEMGQMQVLQMK 1054
+ Q+R ++ LRK ++KE+ EE+RK L+ + LQ K
Sbjct: 1819 LEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAK 1878
Query: 1055 SEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREM 1107
+ K + + N NL+ R+ +E E + ++ E Q K RE+
Sbjct: 1879 VKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKSREV 1931
Score = 130 bits (327), Expect = 8e-30
Identities = 189/861 (21%), Positives = 362/861 (42%), Gaps = 122/861 (14%)
Query: 370 LIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQI 429
L++S T+ E+ + E+ + K +R+E E K LM + + + Q +
Sbjct: 843 LLKSAETEKEMANMKEE--FEKTKEELAKTEAKRKELEEKMVT-LMQEKNDLQLQVQAEA 899
Query: 430 DEIRDKKTGLGRIIELKSEILSK------KQNELKNVKYELQQLEGS-SDRILELDQELI 482
D + D + ++I+ K ++ +K + + + + EL + D EL +++
Sbjct: 900 DSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDID 959
Query: 483 KAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNH-HTTTRTQMEML 541
E L+K EK + K++ +L E A LD T+ KL +E + L H T ++
Sbjct: 960 DLELTLAKVEKEKHATENKVK--NLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQA- 1016
Query: 542 TKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKEL 601
+ DK + K K + ++ L G +K++ L +++ L +
Sbjct: 1017 ---EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGD---LKLAQEST 1070
Query: 602 ASSEQNKNHINNELKRKEEQLSSYEDKLFD--VCGSQ------DFESDLDRLKEEIE--- 650
E +K ++ +LK+KE ++S + K+ D G Q + ++ ++ L+EEIE
Sbjct: 1071 MDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAER 1130
Query: 651 ----KSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLR 706
K+ KQR+ L+ S+ +L + + + + EAE Q++ DL+
Sbjct: 1131 ASRAKAEKQRSDLSRELEEISE---RLEEAGGATSAQIEMNKKREAEFQKMRRDLEE--- 1184
Query: 707 LAPDKLKSTESELKKKEKRRDEMLG-----LVPMRQSIIDLKEK---EIPELRNKLQNVN 758
A + ++T + L+KK LG L ++Q + K + EI +L + ++ V+
Sbjct: 1185 -ATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVS 1243
Query: 759 RDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIME-RFQMELKDVERKI-------- 809
+ L+ E L I +EE + + D+T R Q E + R++
Sbjct: 1244 KAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVS 1303
Query: 810 ----AQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKS 865
+QA Q +L R +++ + K H L + +L R+ +++QE L+
Sbjct: 1304 QLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQR 1363
Query: 866 TTNELKSEKLQISTN-----LQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLE 920
++ SE Q T +QR ++LEE +L+ +Q ++ + + LE T +
Sbjct: 1364 AMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQ 1423
Query: 921 KFQQEKEELINKKNTSNK--IAQDK--------LNDIKEKVKNIHGYMKDIENYIQDGKD 970
+ Q E E+L+ +N A DK L + K+K + H + +
Sbjct: 1424 RLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAEL--------EASQ 1475
Query: 971 DYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDI---------------DTQKIQE 1015
+ TEL K+ E E + + + ++Q+I + +KI++
Sbjct: 1476 KESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKK 1535
Query: 1016 RWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQK----LEENIDNIKRNH 1071
+ Q+ L+ EE + E + + + Q+++ Q+KSE + +E ID +KRNH
Sbjct: 1536 QVEQEKSELQAALEEAEASLEHEEGKILRI-QLELNQVKSEVDRKIAEKDEEIDQMKRNH 1594
Query: 1072 -NLALGRQKGYEEEI------IHFKKELR------EPQFRDAEEKYREMMIVMRTTELVN 1118
+ Q + EI I KK++ E Q A E + R T+ +
Sbjct: 1595 IRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAIL 1654
Query: 1119 KDLDIYYKTLDQAIMKFHSMK 1139
KD ++ LD A+ +K
Sbjct: 1655 KDTQLH---LDDALRSQEDLK 1672
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 134 bits (336), Expect = 7e-31
Identities = 211/1059 (19%), Positives = 433/1059 (40%), Gaps = 145/1059 (13%)
Query: 190 ETLRQVRQTQGQKVK-EYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENEL 248
+ L + Q +K + Q+E K +K+ E+A E ++I A+LT+ K + E+E
Sbjct: 900 DALADAEERCDQLIKTKIQLEAK-IKEVTERA-EDEEEIN---AELTAKK---RKLEDEC 951
Query: 249 DPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLY 308
LK + ++E L+K+ K E A +++ K + ++ + L+E + K+ ++ L
Sbjct: 952 SELKKDIDDLELTLAKVEK---EKHATENKVKNLTEEMAGLDETIAKL----TKEKKALQ 1004
Query: 309 HNHQRTVREKERKLVDCHRELEKLN---KESRLLNQEKSEL---LVEQGRLQLQADRHQE 362
HQ+T L D E +K+N K L Q+ +L L ++ +L + +R +
Sbjct: 1005 EAHQQT-------LDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKR 1057
Query: 363 HIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKL--VRERQEGEAKTANQLMNDFAE 420
+ L Q E D + +E+ K ++ ++ + E E A QL E
Sbjct: 1058 KLEGDLKLAQESTMDTEND---KQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKE 1114
Query: 421 KETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQE 480
+ ++ +EI ++ + + +S++ EL+ + L++ G++ +E+++
Sbjct: 1115 LQARIEELEEEIEAERASRAKAEKQRSDL----SRELEEISERLEEAGGATSAQIEMNK- 1169
Query: 481 LIKAERELSKAEKNSNVETLKME--VISLQNEKAD-----------LDRTLRKLDQEMEQ 527
K E E K ++ TL+ E +L+ + AD L R +KL++E +
Sbjct: 1170 --KREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSE 1227
Query: 528 LNHH-TTTRTQMEMLTKDKAD-------KDEQIRKIKSRHSDELTSLLGYFPNKKQLEDW 579
L + ME ++K KA+ ++Q+ +IK++ ++ + K +
Sbjct: 1228 LKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKAR---- 1283
Query: 580 LHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFE 639
LH++S E ++ D + +L+ +Q ELKR+ E+ + + L Q
Sbjct: 1284 LHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHAL--QSAR 1341
Query: 640 SDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVIS 699
D D L+E+ E+ + +A L + + + Q + ++ Q EL+E
Sbjct: 1342 HDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYET------DAIQRTEELEEAKK 1395
Query: 700 DLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNR 759
L +L+ A + +++ S+ EK + + V ++ L K +N ++
Sbjct: 1396 KLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDK 1455
Query: 760 DIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIM---------------ERFQMELKD 804
+ K EE + L E S L V + Q E+ D
Sbjct: 1456 VLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISD 1515
Query: 805 VERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLK 864
+ +IA+ + +L++ +Q++ EK E Q L+ + +E I Q ++ +K
Sbjct: 1516 LTEQIAEGGKHIH--ELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVK 1573
Query: 865 STTNELKSEKLQISTNLQRR--QQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKF 922
S + +EK + L+R + +E L E++S ++ K K
Sbjct: 1574 SEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKK-----------KM 1622
Query: 923 QQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQD---GKDDYKKQKETE 979
+ + E+ + N +N+ A + L ++ +N G +KD + ++ D G+DD K+
Sbjct: 1623 EGDLNEMEIQLNHANRQAAEALRNL----RNTQGILKDTQLHLDDAIRGQDDLKE----- 1673
Query: 980 LNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERK 1039
QL+ E+ + ++ +R ++ + + + L +L +
Sbjct: 1674 ------QLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSL 1727
Query: 1040 QHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRD 1099
+ K+ + + Q++ E + + + N + A+ EE+ KKE +
Sbjct: 1728 INTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEEL---KKEQDTSAHLE 1784
Query: 1100 AEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQD 1159
+K E + KDL + +Q +K +++++ +R+L
Sbjct: 1785 RMKKNMEQTV---------KDLQLRLDEAEQLALKGGKKQIQKLEARVREL--------- 1826
Query: 1160 IEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMR 1198
E+ S+ NV A R + RV L T D +
Sbjct: 1827 --ESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRK 1863
Score = 107 bits (268), Expect = 6e-23
Identities = 206/1030 (20%), Positives = 403/1030 (39%), Gaps = 215/1030 (20%)
Query: 88 DVNGELIAVQRSMVCTQKSKKTEFKTLEGVITRTKHGEKVSLSSKCAEIDREM------I 141
++N EL A +R + K + LE + + + EK + +K + EM I
Sbjct: 935 EINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK-EKHATENKVKNLTEEMAGLDETI 993
Query: 142 SSLGVSKAVLNNVIFCHQ---------EDSNWPLSEGKA-LKQKFDEIFSATRYIKAL-- 189
+ L K L HQ ED L++ K L+Q+ D++ + K L
Sbjct: 994 AKLTKEKKALQEA---HQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCM 1050
Query: 190 ETLRQVRQTQG--QKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENE 247
+ R R+ +G + +E M+ + KQ ++ +++ KE ++++ + ++ +
Sbjct: 1051 DLERAKRKLEGDLKLAQESTMDTENDKQ------QLNEKLKKKEFEMSNLQGKIEDEQAL 1104
Query: 248 LDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKV----------- 296
L+ ++KE++ ++I +L+ EI+A + + + EK S+L ++E++
Sbjct: 1105 AIQLQKKIKELQ---ARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT 1161
Query: 297 -------------FQGTDEQLNDLYHNHQRTVREKERKLVDCHREL----EKLNKESRLL 339
FQ L + H+ T +K D EL + L + + L
Sbjct: 1162 SAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKL 1221
Query: 340 NQEKSELLVEQGRL-----------------------QLQADRHQEHIRARDSLIQSLAT 376
+EKSEL +E L QL + +E + R LI L+
Sbjct: 1222 EKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQR--LINELSA 1279
Query: 377 QLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKK 436
Q E G FS RQ+ +V + G+ Q+ E LK++ +E + K
Sbjct: 1280 QKARLHTESGEFS-RQLDEKDAMVSQLSRGKQAFTQQI-------EELKRQLEEETKAKS 1331
Query: 437 TGLGRIIELKSE--ILSKKQNELKNVKYELQQLEGSSD----------------RILELD 478
T + + + +L ++ E + K ELQ+ ++ R EL+
Sbjct: 1332 TLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELE 1391
Query: 479 QELIKAERELSKAEK-----NSNVETLKMEVISLQNEKADL--------------DRTLR 519
+ K + L AE+ NS +L+ LQNE DL D+ R
Sbjct: 1392 EAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQR 1451
Query: 520 KLDQEM-EQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLED 578
D+ + E + T+ ++E K+ ++ K+K+ + + L L K L+
Sbjct: 1452 NFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQ 1511
Query: 579 WLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDF 638
+ +++I + + +L K + K+ + L+ E L E K+ +
Sbjct: 1512 EISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRI------ 1565
Query: 639 ESDLDRLKEEI-----EKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAE 693
+ +L+++K EI EK + + V + L E +S + + E +
Sbjct: 1566 QLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGD 1625
Query: 694 LQEVISDLQSKLRLAPDKL----------KSTESELKKKEKRRDEMLGLVPMRQSIIDLK 743
L E+ L R A + L K T+ L + +D++ + M + +L
Sbjct: 1626 LNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLM 1685
Query: 744 EKEIPELRNKLQNVNRDIQ----------------------------RLKNDIEEQETLL 775
+ E+ ELR L+ R + +L+ DI + + +
Sbjct: 1686 QAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEM 1745
Query: 776 GTIMPE----EESAKVCLTDVTIM------------------ERFQMELKDVE------R 807
I+ E EE AK +TD +M + + +KD++
Sbjct: 1746 EDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAE 1805
Query: 808 KIAQQAAKLQGIDLDRTVQQVNQE-KQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKST 866
++A + K Q L+ V+++ E + E++H ++ V + + + +++ Q + +
Sbjct: 1806 QLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKG-LRKHERRVKELTYQTEEDRKN 1864
Query: 867 TNELKS--EKLQISTNLQRRQ--QLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKF 922
L+ +KLQ +RQ + EEQ+ + + L E+++AKE+ E+ + K
Sbjct: 1865 ILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKL 1924
Query: 923 QQEKEELINK 932
+ + E+ K
Sbjct: 1925 RVKSREVHTK 1934
Score = 107 bits (266), Expect = 1e-22
Identities = 159/808 (19%), Positives = 316/808 (39%), Gaps = 129/808 (15%)
Query: 477 LDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRT 536
+ +E K + EL+K E + L+ ++++L EK DL Q + +
Sbjct: 856 MKEEFEKTKEELAKTEAKR--KELEEKMVTLMQEKNDLQL------QVQAEADALADAEE 907
Query: 537 QMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAK 596
+ + L K K + +I+++ R DE K++LED K+I+ LAK
Sbjct: 908 RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 967
Query: 597 LNKELASSEQNKNHINNELKRKEEQLS--SYEDKLFDVCGSQDFESDLDRLKEEIEKSSK 654
+ KE ++E ++ E+ +E ++ + E K Q + DL ++++ +K
Sbjct: 968 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD-DLQMEEDKVNTLTK 1026
Query: 655 QRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKS 714
+ L Q + L + +C +L+ L+ L+LA +
Sbjct: 1027 AKTKL-------EQQVDDLEGSLEQEKKLCM-------DLERAKRKLEGDLKLAQESTMD 1072
Query: 715 TESE-------LKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQ---RL 764
TE++ LKKKE + G + Q++ +K+I EL+ +++ + +I+
Sbjct: 1073 TENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERAS 1132
Query: 765 KNDIEEQETLLGTIMPE-----EESAKVCLTDVTIMER----FQMELKDVERKIAQQAAK 815
+ E+Q + L + E EE+ + + ++ FQ +D+E Q A
Sbjct: 1133 RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEAT 1192
Query: 816 LQGI----------------DLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQ 859
+ L R Q++ +EK E + +++ ++S +E K + ++
Sbjct: 1193 AAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKM 1252
Query: 860 IQHLKSTTNELKSEKLQISTNLQRR--QQLEEQTVELSTEVQSLYREIKDAKEQVSPLET 917
+ L+ +E+K+++ + Q+R +L Q L TE R++ + VS L
Sbjct: 1253 CRTLEDQLSEIKTKEEE-----QQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSR 1307
Query: 918 TLEKFQQEKEELINKKNTSNK-----------------IAQDKLNDIKEKVKNIHGYMKD 960
+ F Q+ EEL + K + +++ + +E + M
Sbjct: 1308 GKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSK 1367
Query: 961 IENYIQDGKDDYK-------KQKETELNKVIAQLSECEKHKEKINE--------DMRLMR 1005
+ + + Y+ ++ E K+ +L + E+H E +N RL
Sbjct: 1368 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQN 1427
Query: 1006 QDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENID 1065
+ D ER + L K+ +V E KQ +E Q ++ + E + L +
Sbjct: 1428 EVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEET-QAELEASQKESRSLSTELF 1486
Query: 1066 NIKRNHNLALGRQKGYEEEIIHFKKELRE-----PQFRDAEEKYREMMIVMRTTELVNKD 1120
+K YEE + H + RE + D E+ E + E V K
Sbjct: 1487 KVK----------NAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQ 1536
Query: 1121 LDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDK-- 1178
LD L ++ + + E KI+R +E +++S+ D ++ D+
Sbjct: 1537 LDHEKSELQTSLEEAEASLEHEEGKILR---------IQLELNQVKSEIDRKIAEKDEEL 1587
Query: 1179 ---RRNYNYRVVMLKGDTALDMRGRCSA 1203
+RN+ V ++ ++R R A
Sbjct: 1588 DQLKRNHLRVVESMQSTLDAEIRSRNDA 1615
Score = 85.5 bits (210), Expect = 3e-16
Identities = 134/744 (18%), Positives = 312/744 (41%), Gaps = 88/744 (11%)
Query: 595 AKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQD-----FESDLDRLKEEI 649
A+ KE+A+ ++ EL + E + E+K+ + ++ +++ D L +
Sbjct: 847 AETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAE 906
Query: 650 EKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTE---AELQEVISDLQSKLR 706
E+ + A + + DE + + + + E +EL++ I DL+ L
Sbjct: 907 ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 966
Query: 707 LAPDKLKSTESELKKKEKRR---DEMLG-LVPMRQSIIDLKEKEIPELRNKLQNVNRDIQ 762
+ +TE+++K + DE + L ++++ + ++ + +L+ + VN +
Sbjct: 967 KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNT-LT 1025
Query: 763 RLKNDIEEQ-ETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDL 821
+ K +E+Q + L G++ E+ K+C+ +ER + +L+ + K+AQ++ +D
Sbjct: 1026 KAKTKLEQQVDDLEGSL---EQEKKLCMD----LERAKRKLEG-DLKLAQEST----MDT 1073
Query: 822 DRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNL 881
+ QQ+N++ ++K+ ++ + KIE + L Q++I+ L++ EL+ E I
Sbjct: 1074 ENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEE---IEAER 1130
Query: 882 QRRQQLEEQTVELSTEVQSLYREIKDAK-------EQVSPLETTLEKFQQEKEE-LINKK 933
R + E+Q +LS E++ + +++A E E +K +++ EE + +
Sbjct: 1131 ASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHE 1190
Query: 934 NTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKH 993
T+ + + + + E + I + ++ + K + + E+N + + + K
Sbjct: 1191 ATAAALRKKHADSVAELGEQIDSLQR-----VKQKLEKEKSELKMEINDLASNMETVSKA 1245
Query: 994 KEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQM 1053
K + R TL + E+K EEE+++ + E+ Q ++
Sbjct: 1246 KANFEKMCR--------------------TLEDQLSEIKTKEEEQQRLINEL-SAQKARL 1284
Query: 1054 KSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRT 1113
+E + +D + ++ + ++I K++L EE+ + +
Sbjct: 1285 HTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQL--------EEETKAKSTLAHA 1336
Query: 1114 TELVNKDLDIYYKTLDQAIMKFHSMK--MEEINKIIRDLWRSTYRGQDIEYIEIRSDADE 1171
+ D D+ + ++ ++ M + N + WR+ Y I+ E +A +
Sbjct: 1337 LQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQ-WRTKYETDAIQRTEELEEAKK 1395
Query: 1172 NVSASDKRRNYNYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGIIALD 1231
++ + + V K + + R Q + L+I + + C IALD
Sbjct: 1396 KLAQRLQDAEEHVEAVNSKCASLEKTKQRL---QNEVEDLMIDVERSNAAC-----IALD 1447
Query: 1232 EPTTNLDR---ENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYR 1288
+ N D+ E + E+ S+ + R+ + + E L +++E R
Sbjct: 1448 KKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESL---DHLETLKR 1504
Query: 1289 IKKNIDQCSEIVKCSVSSLGFNVH 1312
KN+ Q + ++ G ++H
Sbjct: 1505 ENKNLQQEISDLTEQIAEGGKHIH 1528
Score = 40.0 bits (92), Expect = 0.015
Identities = 40/203 (19%), Positives = 92/203 (45%), Gaps = 32/203 (15%)
Query: 890 QTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQ---DKLND 946
++ E E+ ++ E + KE+++ E ++ +++ L+ +KN Q D L D
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALAD 904
Query: 947 IKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQ 1006
+E+ + +E I++ + + + E E+N +E K K+ ++ +++
Sbjct: 905 AEERCDQLIKTKIQLEAKIKEVTE--RAEDEEEIN------AELTAKKRKLEDECSELKK 956
Query: 1007 DIDTQKI------QERWLQDNL-------------TLRKRNEELKEVEEERKQHLK--EM 1045
DID ++ +E+ +N T+ K +E K ++E +Q L +M
Sbjct: 957 DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQM 1016
Query: 1046 GQMQVLQMKSEHQKLEENIDNIK 1068
+ +V + KLE+ +D+++
Sbjct: 1017 EEDKVNTLTKAKTKLEQQVDDLE 1039
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 133 bits (334), Expect = 1e-30
Identities = 202/1008 (20%), Positives = 417/1008 (41%), Gaps = 154/1008 (15%)
Query: 215 QYKEKACEIRDQITSKE---AQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNE 271
Q + K E+ +++ +E A+LT+ K + E+E LK + ++E L+K+ K E
Sbjct: 914 QLEAKVKEMNERLEDEEEMNAELTAKK---RKLEDECSELKRDIDDLELTLAKVEK---E 967
Query: 272 IKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEK 331
A +++ K + ++ + L+E + K+ ++ L HQ+ L D E +K
Sbjct: 968 KHATENKVKNLTEEMAGLDEIIAKL----TKEKKALQEAHQQA-------LDDLQAEEDK 1016
Query: 332 LN---KESRLLNQEKSEL---LVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFER 385
+N K L Q+ +L L ++ ++++ +R + + L Q LE D +
Sbjct: 1017 VNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEND---K 1073
Query: 386 GPFSERQIKNFHKL--VRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRII 443
ER K +L + R E E +QL E + ++ +E+ ++T ++
Sbjct: 1074 QQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVE 1133
Query: 444 ELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKME 503
+L+S++ EL+ + L++ G++ +E+++ K E E K ++ TL+ E
Sbjct: 1134 KLRSDL----SRELEEISERLEEAGGATSVQIEMNK---KREAEFQKMRRDLEEATLQHE 1186
Query: 504 --VISLQNEKAD-----------LDRTLRKLDQEMEQLNHHTTTRT-QMEMLTKDKADKD 549
+L+ + AD L R +KL++E + T ME + K KA+ +
Sbjct: 1187 ATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLE 1246
Query: 550 EQIRKIK---SRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQ 606
+ R ++ + H + + L +++ E+++ D L +L +
Sbjct: 1247 KMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKL 1306
Query: 607 NKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDL--DRLKEEIEKSSKQRAMLAGATA 664
+LKR+ E+ ++ L S + DL ++ +EE E ++ + +L+ A +
Sbjct: 1307 TYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANS 1366
Query: 665 VYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEK 724
+Q+ T+ + Q EL+E L +L+ A + +++ ++ EK
Sbjct: 1367 EVAQWRTKYETD----------AIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEK 1416
Query: 725 RRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEES 784
+ + + ++ L K +N ++ + K EE ++ L + E S
Sbjct: 1417 TKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARS 1476
Query: 785 AKVCL--------TDVTIMERFQMELKDVERKIAQQAAKLQGI-----DLDRTVQQVNQE 831
L + +E F+ E K+++ +I+ +L +L++ +Q+ E
Sbjct: 1477 LSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAE 1536
Query: 832 KQEKQHKLDTVSS-------------------KIELNRKLIQDQQEQIQ----HLK---- 864
K E Q L+ + K E+ RKL + +E Q HL+
Sbjct: 1537 KMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDS 1596
Query: 865 ---STTNELKSEKLQISTNLQRRQQLEEQTVELS----------TEVQSLYREIKDA--- 908
S E +S + + L E ++LS +V+SL +KD
Sbjct: 1597 LQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 1656
Query: 909 -----------KEQVSPLETTLEKFQQEKEEL---INKKNTSNKIAQDKLNDIKEKVKNI 954
KE ++ +E Q E EEL + + S K+A+ +L + E+V+ +
Sbjct: 1657 LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLL 1716
Query: 955 HGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQ 1014
H + N + D Q +TE+ + + + E+ +K D +M +++ ++
Sbjct: 1717 HSQNTSLINQ-KKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQ-- 1773
Query: 1015 ERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLA 1074
+ L + + +++ ++ + L E Q+ + K + QKLE + ++ N
Sbjct: 1774 ----DTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELE---NEL 1826
Query: 1075 LGRQKGYEEEIIHFKKELREPQFRDAEEKYR---EMMIVMRTTELVNK 1119
QK E + K +R+ + R E Y+ + ++R +LV+K
Sbjct: 1827 EAEQKRNAESV----KGMRKSERRIKELTYQTEEDRKNLLRLQDLVDK 1870
Score = 113 bits (283), Expect = 1e-24
Identities = 188/899 (20%), Positives = 379/899 (42%), Gaps = 150/899 (16%)
Query: 317 EKERKLVDCHRE-------LEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIR-ARD 368
E+E+++ E LEK + L ++ LL E+ LQLQ Q+++ A +
Sbjct: 844 EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEE 903
Query: 369 SLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQ 428
Q + +++L E ++K ++ + + +E MN AE K+K
Sbjct: 904 RCDQLIKNKIQL---------EAKVKEMNERLEDEEE---------MN--AELTAKKRKL 943
Query: 429 IDEIRDKKTGLGRIIELKSEILSKK---QNELKNVKYELQQLEGSSDRILELDQELIKAE 485
DE + K + + +++ +K +N++KN+ E+ L+ E+ +L K +
Sbjct: 944 EDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD-------EIIAKLTKEK 996
Query: 486 RELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDK 545
+ L +A + + ++ L+ E +++ L + KL+Q+++ L +E K +
Sbjct: 997 KALQEAHQQA-LDDLQAE----EDKVNTLTKAKVKLEQQVDDL------EGSLEQEKKVR 1045
Query: 546 ADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSE 605
D + RK++ S++ +K+QL++ L K E+N A++ E A
Sbjct: 1046 MDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALN---ARIEDEQALGS 1102
Query: 606 QNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAV 665
Q + + R EE E + + SDL R E+E+ S++ GAT+V
Sbjct: 1103 QLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSR---ELEEISERLEEAGGATSV 1159
Query: 666 YSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKR 725
+ + EAE Q++ DL+ A + ++T + L+KK
Sbjct: 1160 QIEMNK-----------------KREAEFQKMRRDLEE----ATLQHEATAAALRKKHAD 1198
Query: 726 RDEMLG-LVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRL---KNDIEEQETLLGTIMPE 781
LG + Q + EKE E + +L +V +++++ K ++E+ L M E
Sbjct: 1199 SVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNE 1258
Query: 782 E----ESAKVCLTDVTIME-RFQMELKDVERKIAQQAAKLQGI------------DLDRT 824
E + + D+T + Q E ++ R++ ++ A + + DL R
Sbjct: 1259 HRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQ 1318
Query: 825 VQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTN---- 880
+++ + K H L + +L R+ +++ E L+ ++ SE Q T
Sbjct: 1319 LEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETD 1378
Query: 881 -LQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKI 939
+QR ++LEE +L+ +Q ++ + S LE T + Q E E+L+ SN
Sbjct: 1379 AIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAA 1438
Query: 940 AQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYK-KQKE-----TELNKVIAQLSECEKH 993
A + +K +N + + + ++ + + + QKE TEL K+ E +H
Sbjct: 1439 AA----ALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH 1494
Query: 994 KEKINEDMRLMRQDI---------------DTQKIQERWLQDNLTLRKRNEELK-EVEEE 1037
E + + ++++I + +K++++ + + L+ EE + +E E
Sbjct: 1495 LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE 1554
Query: 1038 RKQHLKEMGQMQVLQMKSEHQK----LEENIDNIKRNH-------NLALGRQKGYEEEII 1086
+ L+ Q++ Q+K+E ++ +E ++ KRNH +L + E +
Sbjct: 1555 EGKILR--AQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEAL 1612
Query: 1087 HFKKELR------EPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMK 1139
KK++ E Q A E +++ + + KD I LD A+ +K
Sbjct: 1613 RVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQI---QLDDAVRANDDLK 1668
Score = 100 bits (248), Expect = 1e-20
Identities = 173/819 (21%), Positives = 333/819 (40%), Gaps = 126/819 (15%)
Query: 462 YELQQLEGSSDRILEL---DQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTL 518
++++ L S++R E+ +E + + L K+E + L+ +++SL EK DL
Sbjct: 834 FKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARR--KELEEKMVSLLQEKNDL---- 887
Query: 519 RKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLED 578
+L + EQ N + + L K+K + +++++ R DE K++LED
Sbjct: 888 -QLQVQAEQDNL-ADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLED 945
Query: 579 WLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNEL-----------KRKEEQLSSYED 627
++I+ LAK+ KE ++E ++ E+ K K+ +++
Sbjct: 946 ECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQ 1005
Query: 628 KLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRV 687
L D+ +D + L + K ++E +Q L G+ L E + + +
Sbjct: 1006 ALDDLQAEEDKVNTLTKAKVKLE---QQVDDLEGS----------LEQEKKVRMDLERAK 1052
Query: 688 FQTEAEL---QEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKE 744
+ E +L QE I DL++ + ++LK + EL R ++ L Q + +
Sbjct: 1053 RKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQ 1112
Query: 745 KEIPELRNKLQ---NVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIME--RFQ 799
I EL +L+ +++L++D+ + + + E A ++ FQ
Sbjct: 1113 ARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQ 1172
Query: 800 MELKDVE--------------RKIAQQAAKL--QGIDLDRTVQQVNQEKQEKQHKLDTVS 843
+D+E +K A A+L Q +L R Q++ +EK E + +LD V+
Sbjct: 1173 KMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVT 1232
Query: 844 SKIELNRKLIQDQQEQIQHLKSTTNE--LKSEKLQISTNLQRRQQLEEQTVELSTEVQSL 901
S +E K + ++ + L+ NE K+E+ Q S N L Q +L TE L
Sbjct: 1233 SNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVN-----DLTSQRAKLQTENGEL 1287
Query: 902 YREIKDAKEQVSPL-------ETTLEKFQQEKEELINKKNTSNKIAQDKLND---IKEKV 951
R++ + + +S L LE +++ EE + KN Q +D ++E+
Sbjct: 1288 SRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQY 1347
Query: 952 KNIHGYMKDIENYIQDGKDD---YKKQKET----------ELNKVIAQ-LSECEKHKEKI 997
+ +++ + + ++ + ET E K +AQ L E E+ E +
Sbjct: 1348 EEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAV 1407
Query: 998 NEDM--------RLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQ 1049
N RL + D ER L K+ ++ E KQ +E Q +
Sbjct: 1408 NAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEE-SQSE 1466
Query: 1050 VLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIH---FKKELR--EPQFRDAEEKY 1104
+ + E + L + +K YEE + H FK+E + + + D E+
Sbjct: 1467 LESSQKEARSLSTELFKLK----------NAYEESLEHLETFKRENKNLQEEISDLTEQL 1516
Query: 1105 REMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIE 1164
+ E V K L+ L A+ + + E KI+R +E+ +
Sbjct: 1517 GSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILR---------AQLEFNQ 1567
Query: 1165 IRSDADENVSASD---KRRNYNYRVVMLKGDTALDMRGR 1200
I+++ + ++ D ++ N+ V+ T+LD R
Sbjct: 1568 IKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETR 1606
Score = 67.4 bits (163), Expect = 9e-11
Identities = 153/709 (21%), Positives = 292/709 (41%), Gaps = 151/709 (21%)
Query: 74 QETDVRAQIRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITRTKHGEKVSLSSKC 133
+ET+ +A+++ N E +A R+ T ++TE E + K +++ + +
Sbjct: 1349 EETEAKAELQRVLSKANSE-VAQWRTKYETDAIQRTE----ELEEAKKKLAQRLQEAEEA 1403
Query: 134 AEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQK---FDEIFSATRYIKALE 190
E SSL +K L N I D + AL +K FD+I + +
Sbjct: 1404 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWK------ 1457
Query: 191 TLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSK--EIVKSYENEL 248
QK +E Q EL + + KEA+ S++ ++ +YE L
Sbjct: 1458 ----------QKYEESQSEL---------------ESSQKEARSLSTELFKLKNAYEESL 1492
Query: 249 DPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELE-EKMEKVFQGTDEQLNDL 307
+ L+ +E ++ +I L ++ + ++EK +LE EKME L
Sbjct: 1493 EHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKME---------LQSA 1543
Query: 308 YHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRAR 367
+ ++ +E K++ E ++ E EK E + EQ + + H+R
Sbjct: 1544 LEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEM-EQAK--------RNHLRVV 1594
Query: 368 DSLIQSLATQ-------LELDGFERGPFSERQIKNFH--KLVRERQEGEAKTANQLMNDF 418
DSL SL + L + G +E +I+ H ++ E Q+ + K+ L+ D
Sbjct: 1595 DSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQK-QVKSLQSLLKDT 1653
Query: 419 AEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELD 478
+ + D++++ I+E ++ +L Q EL+ ++ ++Q E S +
Sbjct: 1654 QIQLDDAVRANDDLKENIA----IVERRNNLL---QAELEELRAVVEQTERSRKL---AE 1703
Query: 479 QELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQM 538
QELI E + V+ L + SL N+K +K+D ++ QL +T++
Sbjct: 1704 QELI---------ETSERVQLLHSQNTSLINQK-------KKMDADLSQL------QTEV 1741
Query: 539 EMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLN 598
E ++ + +E+ KK + D ++E+ + +D A L
Sbjct: 1742 EEAVQECRNAEEKA--------------------KKAITD-AAMMAEELKKEQDTSAHLE 1780
Query: 599 KELASSEQNKNHINNELKRKEE-QLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRA 657
+ + EQ + + L E+ L + +L Q E+ + L+ E+E K+ A
Sbjct: 1781 RMKKNMEQTIKDLQHRLDEAEQIALKGGKKQL------QKLEARVRELENELEAEQKRNA 1834
Query: 658 MLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEV--ISDLQSKLRLAPDKLKST 715
+ I +LT +QTE + + + + DL KL+L K+K+
Sbjct: 1835 ESVKGMRKSERRIKELT-------------YQTEEDRKNLLRLQDLVDKLQL---KVKAY 1878
Query: 716 ESELKKKEKRRDEMLGLVPMRQSIIDLKEK--EIPELR-NKLQNVNRDI 761
+ + ++ E++ + L Q +D E+ +I E + NKL+ +RDI
Sbjct: 1879 KRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDI 1927
Score = 45.4 bits (106), Expect = 3e-04
Identities = 67/353 (18%), Positives = 154/353 (43%), Gaps = 44/353 (12%)
Query: 845 KIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTV-------ELSTE 897
K+ K + E+ + + S E K + + RR++LEE+ V +L +
Sbjct: 831 KLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQ 890
Query: 898 VQSLYREIKDAKEQVS-------PLETTLEKFQQ--EKEELINKKNTSNK-IAQDKLNDI 947
VQ+ + DA+E+ LE +++ + E EE +N + T+ K +D+ +++
Sbjct: 891 VQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSEL 950
Query: 948 KEKVKNIHGYMKDI--ENYIQDGKDDYKKQKETELNKVIAQLSECEK-----HKEKINED 1000
K + ++ + + E + + K ++ L+++IA+L++ +K H++ + +D
Sbjct: 951 KRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQAL-DD 1009
Query: 1001 MRLMRQDIDT---QKIQERWLQDNLTLRKRNEELKEVEEERKQHLKE----MGQMQVLQM 1053
++ ++T K++ D+L E+ ++ ER + E + Q ++ +
Sbjct: 1010 LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL 1069
Query: 1054 KSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFR--DAEEKYREMMIVM 1111
+++ Q+L+E + N R + + +K+L+E Q R + EE+
Sbjct: 1070 ENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTAR 1129
Query: 1112 RTTELVNKDLDIYYKTLDQAI----------MKFHSMKMEEINKIIRDLWRST 1154
E + DL + + + + ++ + + E K+ RDL +T
Sbjct: 1130 AKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEAT 1182
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 132 bits (332), Expect = 2e-30
Identities = 202/1055 (19%), Positives = 452/1055 (42%), Gaps = 182/1055 (17%)
Query: 181 SATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSK---------- 230
+A + +ETL+ Q +K+ + Q +L+ + +A E+R ++T+K
Sbjct: 863 AAENRLTEMETLQS--QLMAEKL-QLQEQLQAETELCAEAEELRARLTAKKQELEEICHD 919
Query: 231 -EAQLTSSKEIVKSYENELDPLKNRLKEIEHNL------------------SKIMKLDNE 271
EA++ +E + + E ++ ++E+E L +K+ KL+ E
Sbjct: 920 LEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEE 979
Query: 272 IKALDSRKKQMEKDNSELEEKMEKVFQGTDEQ------LNDLYHNHQRTVREKERKLVDC 325
L+ + ++ K+ LE+++ + E+ L L + H+ + + E +L
Sbjct: 980 QIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRRE 1039
Query: 326 HRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFER 385
++ ++L K R L + ++L + LQ Q + + ++ +Q+ ++E + ++
Sbjct: 1040 EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQK 1099
Query: 386 GPFSERQIKNFHKLVRERQEG-EAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIE 444
+ ++I+ + E QE E++ A++ + AEK+ K+ +E+ KT L ++
Sbjct: 1100 N-MALKKIRELESQISELQEDLESERASR---NKAEKQ--KRDLGEELEALKTELEDTLD 1153
Query: 445 ---LKSEILSKKQNELKNVKYELQQLEGSSD-RILELDQELIKAERELSKA-EKNSNVET 499
+ E+ SK++ E+ +K L++ + + +I E+ Q+ +A EL++ E+ V+
Sbjct: 1154 STAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKA 1213
Query: 500 -LKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSR 558
L+ +L+NE+ +L ++ L Q H R ++E ++ K + ++++
Sbjct: 1214 NLEKAKQTLENERGELANEVKVLLQGKGDSEHK---RKKVEAQLQELQVKFNEGERVRTE 1270
Query: 559 HSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRK 618
+D++T L Q+E L + + ++Q+ + +KL K+ ++ E L+ +
Sbjct: 1271 LADKVTKL--------QVE--LDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEE 1320
Query: 619 EEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQ 678
Q S KL V + S ++L+EE E +A A + ++ D +
Sbjct: 1321 NRQKLSLSTKLKQV--EDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMED-SV 1377
Query: 679 SCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQS 738
C + V + + E +S + A DKL+ T++ L+ ++ D ++ L RQS
Sbjct: 1378 GCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQ--QELDDLLVDLDHQRQS 1435
Query: 739 IIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERF 798
+L++K+ ++ + E++T+ E + A+ E
Sbjct: 1436 ACNLEKKQ---------------KKFDQLLAEEKTISAKYAEERDRAEA--------EAR 1472
Query: 799 QMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQE 858
+ E K + A + A Q +L+R +Q E ++ D V + K + ++
Sbjct: 1473 EKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQ 1532
Query: 859 QIQHLKSTTNELKSE-------KLQISTNLQ------------RRQQLEEQTVELSTEVQ 899
Q++ +K+ EL+ E KL++ NLQ R +Q EE+ +L +V+
Sbjct: 1533 QVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVR 1592
Query: 900 SLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMK 959
+ E++D ++Q S +K + + ++L +++NK + + +++ + M+
Sbjct: 1593 EMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMR 1652
Query: 960 DI-------ENYIQDGKDDYKKQK--ETELNKVIAQLSECEKHKEKINEDMRLMRQDI-- 1008
++ E + K++ KK K E E+ ++ +L+ E+ K + ++ + +I
Sbjct: 1653 ELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIAN 1712
Query: 1009 -------------------------------DTQKIQERWLQDNLT-------------- 1023
+T+ I +R + NL
Sbjct: 1713 SSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSH 1772
Query: 1024 ----------LRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNL 1073
L ++N+ELK +E + +K + + ++++ +LEE +DN +
Sbjct: 1773 AQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQA 1832
Query: 1074 ALGR----QKGYEEEIIHFKKELRE-PQFRDAEEK 1103
A + +K ++ ++ E R Q++D +K
Sbjct: 1833 ACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADK 1867
Score = 132 bits (331), Expect = 3e-30
Identities = 199/938 (21%), Positives = 418/938 (44%), Gaps = 135/938 (14%)
Query: 230 KEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSEL 289
+E + +E+VK E +L +NRL E+E S++M +++ + Q E +
Sbjct: 844 EEEMMAKEEELVKVREKQL-AAENRLTEMETLQSQLMAEKLQLQ----EQLQAETELCAE 898
Query: 290 EEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVE 349
E++ ++L ++ H+ + V E+E + E +K+ + + L ++ E E
Sbjct: 899 AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEE--EE 956
Query: 350 QGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQI---KNFHKLVRERQEG 406
R +LQ ++ + T+ +L E E QI KL +E++
Sbjct: 957 SARQKLQ--------------LEKVTTEAKLKKLE-----EEQIILEDQNCKLAKEKKLL 997
Query: 407 EAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQ 466
E + A N E+E K K + ++++K + +E + K++ EL+ + ++
Sbjct: 998 EDRIAEFTTNLTEEEE--KSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTR---RK 1052
Query: 467 LEGS----SDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLD 522
LEG SD+I EL ++ + + +L+K E E L+ + ++ E A + L+K+
Sbjct: 1053 LEGDSTDLSDQIAELQAQIAELKMQLAKKE-----EELQAALARVEEEAAQKNMALKKI- 1106
Query: 523 QEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHS 582
+E+E + E +++KA+K K +EL +L K +LED L S
Sbjct: 1107 RELESQISELQEDLESERASRNKAEKQ------KRDLGEELEAL------KTELEDTLDS 1154
Query: 583 KSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDL 642
+ + +EL S + + +N K EE+ ++E ++ ++ Q +
Sbjct: 1155 TAAQ------------QELRSKREQE--VNILKKTLEEEAKTHEAQIQEM--RQKHSQAV 1198
Query: 643 DRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQ 702
+ L E++E++ + +A L A +L +E + +++ + +LQ
Sbjct: 1199 EELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQ 1258
Query: 703 SKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQ 762
K ++ K + D + GL+ S K+ L ++LQ+ +Q
Sbjct: 1259 VKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQ 1318
Query: 763 -----------RLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQ 811
+LK +E+++ + EEE AK L + ++ D+++K+
Sbjct: 1319 EENRQKLSLSTKLK-QVEDEKNSFREQLEEEEEAKHNLEKQ--IATLHAQVADMKKKMED 1375
Query: 812 QAAKLQGID-----LDRTVQQVNQEKQEK---QHKLDTVSSKI--ELNRKLIQ-DQQEQ- 859
L+ + L + ++ ++Q +EK KL+ +++ EL+ L+ D Q Q
Sbjct: 1376 SVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQS 1435
Query: 860 ---IQHLKSTTNELKSEKLQISTN-LQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPL 915
++ + ++L +E+ IS + R + E + E T+ SL R +++A EQ + L
Sbjct: 1436 ACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAEL 1495
Query: 916 ETTLEKFQQEKEELINKKNTSNKIAQD---KLNDIKEKVKNIHGYMKDIENYIQDGKDDY 972
E ++F+ E E+L++ K+ K + ++++V+ + ++++E+ +Q +D
Sbjct: 1496 ERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQ-ATEDA 1554
Query: 973 KKQKETELNKVIAQL--------SECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTL 1024
K + E L + AQ + E+ K+++ +R M +++ ++ Q +
Sbjct: 1555 KLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMA---VAA 1611
Query: 1025 RKRNE-ELKEVE-------EERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALG 1076
RK+ E +LK++E + R + +K++ ++Q QMK ++L++ R LA
Sbjct: 1612 RKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQA-QMKDCMRELDDT--RASREEILAQA 1668
Query: 1077 RQ-----KGYEEEIIHFKKEL--REPQFRDAEEKYREM 1107
++ K E E+I ++EL E R A+++ E+
Sbjct: 1669 KENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDEL 1706
Score = 117 bits (292), Expect = 9e-26
Identities = 204/993 (20%), Positives = 422/993 (42%), Gaps = 164/993 (16%)
Query: 125 EKVSLSSKCAEIDREMI------SSLGVSKAVLNNVI------FCHQEDSNWPLSEGKAL 172
EKV+ +K +++ E I L K +L + I +E+ + L++ L
Sbjct: 965 EKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAK---L 1021
Query: 173 KQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEA 232
K K + + I LE + + Q Q++++ + +L+ + ++ DQI +A
Sbjct: 1022 KNKHEAM------ITDLEERLRREEKQRQELEKTRRKLE------GDSTDLSDQIAELQA 1069
Query: 233 QLTSSKEIVKSYENELDPLKNR-----------LKEIEHNLSKIMKLDNEIKALDSRKKQ 281
Q+ K + E EL R LK+I S+I +L ++++ + + +
Sbjct: 1070 QIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNK 1129
Query: 282 MEKDNSELEEKMEKVFQGTDEQLNDLYHNHQ-RTVREKERKLVDCHRELEKLNKESRL-- 338
EK +L E++E + ++ L+ + R+ RE+E ++ E E E+++
Sbjct: 1130 AEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQE 1189
Query: 339 LNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQS----LATQLELDGFERGPFSERQIK 394
+ Q+ S+ + E Q R + ++ +++ LA ++++ +G SE + K
Sbjct: 1190 MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGD-SEHKRK 1248
Query: 395 NFHKLVRERQ----EGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEIL 450
++E Q EGE ++ + A+K T Q ++D + TGL + KS L
Sbjct: 1249 KVEAQLQELQVKFNEGE-----RVRTELADKVTKLQVELDNV----TGLLSQSDSKSSKL 1299
Query: 451 SKKQNELKNVKYELQQLEGSSDR-ILELDQELIKAERELSK-----AEKNSNVETLKMEV 504
+K + L++ + Q+L +R L L +L + E E + E+ L+ ++
Sbjct: 1300 TKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQI 1359
Query: 505 ISLQNEKADLDRTL--------------RKLDQEMEQLNHHTTTRTQMEMLTKDKADKDE 550
+L + AD+ + + RKL +++E L+ ++K +
Sbjct: 1360 ATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQR----------HEEKVAAYD 1409
Query: 551 QIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQ--------------TRDRLAK 596
++ K K+R EL LL +++Q L K K+ +Q RDR
Sbjct: 1410 KLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEA 1469
Query: 597 LNKE-------LASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEI 649
+E LA + + EL+R +Q + ++ D+ S+D D+ + E+
Sbjct: 1470 EAREKETKALSLARALEEAMEQKAELERLNKQ---FRTEMEDLMSSKD---DVGKSVHEL 1523
Query: 650 EKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRV-FQTEAELQEVISDLQSKLRLA 708
EKS +RA+ + +Q + +L DE Q+ R+ +A + DLQ + +
Sbjct: 1524 EKS--KRALEQQVEEMKTQ-LEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQS 1580
Query: 709 PDKLKS-----TESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQR 763
+K K E E + +++R+ + + ++ +DLK +L + + N++
Sbjct: 1581 EEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLK-----DLEAHIDSANKNRDE 1635
Query: 764 LKNDIEEQETLLGTIMPEEESAKVCLTDVTIM-ERFQMELKDVERKIAQQAAKLQGIDLD 822
+ + + + M E + + ++ + + +LK +E ++ Q +L +
Sbjct: 1636 AIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAA--AE 1693
Query: 823 RTVQQVNQEKQEKQHKLDTVSSK----IELNRKL---IQDQQEQIQHLKSTT----NELK 871
R +Q QE+ E ++ S K +E R+L I +E+++ + T + LK
Sbjct: 1694 RAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLK 1753
Query: 872 SEKLQI-----STNLQR---------RQQLEEQTVELSTEVQSLYREIKDA-KEQVSPLE 916
LQI NL+R RQQLE Q EL ++Q + +K K ++ LE
Sbjct: 1754 KANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALE 1813
Query: 917 TTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQK 976
+ + +++ + ++ + K + +K+ + + ++ E Y D +
Sbjct: 1814 AKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQY-----KDQADKA 1868
Query: 977 ETELNKVIAQLSECEKHKEKINEDMRLMRQDID 1009
T L ++ QL E E+ ++ N R ++++++
Sbjct: 1869 STRLKQLKRQLEEAEEEAQRANASRRKLQRELE 1901
Score = 108 bits (271), Expect = 3e-23
Identities = 170/851 (19%), Positives = 354/851 (41%), Gaps = 125/851 (14%)
Query: 104 QKSKKTEFKTLEGVIT--RTKHGEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQED 161
+K+ + E KT E I R KH + V ++ E + + ++L +K L N +
Sbjct: 1173 KKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLEN-------E 1225
Query: 162 SNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVK--------EYQMELK-- 211
+E K L Q + + ++A QV+ +G++V+ + Q+EL
Sbjct: 1226 RGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNV 1285
Query: 212 --YLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLD 269
L Q K+ ++ ++ E+QL ++E+++ + L +LK++E +
Sbjct: 1286 TGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKN------ 1339
Query: 270 NEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHREL 329
S ++Q+E++ E + +EK Q+ D+ ++K V C
Sbjct: 1340 -------SFREQLEEEE-EAKHNLEKQIATLHAQVADM--------KKKMEDSVGCLETA 1383
Query: 330 E----KLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFER 385
E KL K+ L+Q E + +L+ R Q+ + D L+ L Q +
Sbjct: 1384 EEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQEL---DDLLVDLDHQRQ-----S 1435
Query: 386 GPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIEL 445
E++ K F +L+ E + AK +AE+ + + E K L R +E
Sbjct: 1436 ACNLEKKQKKFDQLLAEEKTISAK--------YAEERDRAEAEAREKETKALSLARALEE 1487
Query: 446 KSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKA--EKNSNVETLKME 503
E ++ + K + E++ L S D + + EL K++R L + E + +E L+ E
Sbjct: 1488 AMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDE 1547
Query: 504 VISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDEL 563
+ + ++ K L+ L+ + + E+ + + E + K Q+R++++ DE
Sbjct: 1548 LQATEDAKLRLEVNLQAMKAQFER-----DLQGRDEQSEEKKKQLVRQVREMEAELEDE- 1601
Query: 564 TSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLS 623
+KQ + ++ K +D L + S+ +N++ +L++ + Q+
Sbjct: 1602 ---------RKQRSMAVAARKKLEMDLKD----LEAHIDSANKNRDEAIKQLRKLQAQMK 1648
Query: 624 SYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPV 683
+L D S+ E L + KE +K A + QL +E +
Sbjct: 1649 DCMRELDDTRASR--EEILAQAKENEKKLKSMEAEMI-----------QLQEELAAAERA 1695
Query: 684 CQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLK 743
++ Q EL + I++ K LA ++ + E+ + + E+ +E Q +L
Sbjct: 1696 KRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEE-------EQGNTELI 1748
Query: 744 EKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDV--TIMERFQME 801
+ + ++ +N D+ ++ ++ E + + + KV L ++ T+ +++
Sbjct: 1749 NDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKAS 1808
Query: 802 LKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQ 861
+ +E KIAQ +L +R Q ++ + + KL V +++ R+ + ++Q
Sbjct: 1809 ITALEAKIAQLEEQLDNETKER--QAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQAD 1866
Query: 862 HLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEK 921
+ +LK ++ ++ EE+ + + L RE++DA E T +
Sbjct: 1867 KASTRLKQLK----------RQLEEAEEEAQRANASRRKLQRELEDATE-------TADA 1909
Query: 922 FQQEKEELINK 932
+E L NK
Sbjct: 1910 MNREVSSLKNK 1920
Score = 105 bits (262), Expect = 3e-22
Identities = 155/745 (20%), Positives = 315/745 (42%), Gaps = 115/745 (15%)
Query: 77 DVRAQIRLQFRDVNGELIAVQRSMVCTQKSKKT-EFKTLEGVITRTK------HGEKVSL 129
D +++++ +V G L S ++ SK T +F LE + T+ + +K+SL
Sbjct: 1273 DKVTKLQVELDNVTGLL-----SQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSL 1327
Query: 130 SSKCAEID------REMISSLGVSKAVLNNVIFC----------HQEDSNWPLSEGKALK 173
S+K +++ RE + +K L I EDS L + +K
Sbjct: 1328 STKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVK 1387
Query: 174 QKFDEIFS--ATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKE 231
+K + + R+ + + ++ +T+ + +E L L ++ AC + + +
Sbjct: 1388 RKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFD 1447
Query: 232 AQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEE 291
L K I Y E D + +E E +K + L ++ +K ++E+ N +
Sbjct: 1448 QLLAEEKTISAKYAEERDRAEAEAREKE---TKALSLARALEEAMEQKAELERLNKQFRT 1504
Query: 292 KMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQG 351
+ME + D+ + H +++ R E+++ + +LE+L E + E
Sbjct: 1505 EMEDLMSSKDD-VGKSVHELEKSKRALEQQVEEMKTQLEELEDELQA---------TEDA 1554
Query: 352 RLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTA 411
+L+L+ + +Q++ Q E D R SE + K +LVR+ +E EA+
Sbjct: 1555 KLRLEVN------------LQAMKAQFERDLQGRDEQSEEKKK---QLVRQVREMEAELE 1599
Query: 412 NQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGS- 470
++ KQ+ + KK + + +L++ I S +N + +K +L++L+
Sbjct: 1600 DER----------KQRSMAVAARKKLEMD-LKDLEAHIDSANKNRDEAIK-QLRKLQAQM 1647
Query: 471 SDRILELDQELIKAERELSKAEKNSN-VETLKMEVISLQNEKADLDRTLRKLDQEMEQLN 529
D + ELD E L++A++N +++++ E+I LQ E A +R R+ QE ++L
Sbjct: 1648 KDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELA 1707
Query: 530 HHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQ 589
+ L E+ R++++R + QLE+ L +
Sbjct: 1708 DEIANSSGKGALAL------EEKRRLEARIA--------------QLEEELEEEQGNTEL 1747
Query: 590 TRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEI 649
DRL K N ++ + IN +L + E+ Q E LK ++
Sbjct: 1748 INDRLKKANLQI-------DQINTDLNLERSHAQKNEN------ARQQLERQNKELKVKL 1794
Query: 650 EK-----SSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSK 704
++ SK +A + A +Q QL +E + C++V +TE +L++V+ + +
Sbjct: 1795 QEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDE 1854
Query: 705 LRLA---PDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDI 761
R A D+ + LK+ +++ +E + ++E+ + +NR++
Sbjct: 1855 RRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREV 1914
Query: 762 QRLKNDIEEQETLLGTIMPEEESAK 786
LKN + + L ++P + K
Sbjct: 1915 SSLKNKLRRGD--LPFVVPRRMARK 1937
Score = 99.8 bits (247), Expect = 2e-20
Identities = 139/683 (20%), Positives = 294/683 (43%), Gaps = 106/683 (15%)
Query: 464 LQQLEGSSDRILELDQELIKA-ERELSKAEKNSNVETLKMEVISLQNEKADLDRTLR--- 519
L Q+ + ++ ++EL+K E++L+ + + +ETL+ ++++ EK L L+
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMA---EKLQLQEQLQAET 893
Query: 520 KLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDW 579
+L E E+L T + K++LE+
Sbjct: 894 ELCAEAEELRARLTAK-------------------------------------KQELEEI 916
Query: 580 LHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYE-DKLFDVCGSQDF 638
H + + +R L E +QN + +L+ +E + +K+ +
Sbjct: 917 CHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKL 976
Query: 639 ESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVI 698
E + L+++ K +K++ +L A +F T LT+E + + + + EA +I
Sbjct: 977 EEEQIILEDQNCKLAKEKKLLEDRIA---EFTTNLTEEEEKSKSLAKLKNKHEA----MI 1029
Query: 699 SDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVN 758
+DL+ +LR E + ++ EK R ++ G DL + +I EL+ ++ +
Sbjct: 1030 TDLEERLR-------REEKQRQELEKTRRKLEG------DSTDLSD-QIAELQAQIAELK 1075
Query: 759 RDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMEL-KDVE-RKIAQQAAKL 816
+ + + EE + L + E + L + +E EL +D+E + ++ A+
Sbjct: 1076 MQLAKKE---EELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEK 1132
Query: 817 QGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKST-TNELKSEKL 875
Q DL ++ + K E + LD+ +++ EL K +++++ LK T E K+ +
Sbjct: 1133 QKRDLGEELEAL---KTELEDTLDSTAAQQELRSK----REQEVNILKKTLEEEAKTHEA 1185
Query: 876 QISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNT 935
QI Q+ Q E+ E +++ K + LE + + E+ EL N+
Sbjct: 1186 QIQEMRQKHSQAVEELAE----------QLEQTKRVKANLEKAKQTLENERGELANEV-- 1233
Query: 936 SNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGK------DDYKKQKETELNKVIAQLSE 989
K+ D + K K + +++++ +G+ D + + EL+ V LS+
Sbjct: 1234 --KVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQ 1291
Query: 990 CEKHKEKINEDMRLMRQDI-DTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQM 1048
+ K+ +D + + DTQ++ + + L+L + +LK+VE+E+ +++ +
Sbjct: 1292 SDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSL---STKLKQVEDEKNSFREQLEEE 1348
Query: 1049 QVLQMKSEHQ--KLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYRE 1106
+ + E Q L + ++K+ ++G + EE +K+L E + EEK
Sbjct: 1349 EEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDL-EGLSQRHEEKVAA 1407
Query: 1107 MMIVMRTTELVNKDLDIYYKTLD 1129
+ +T + ++LD LD
Sbjct: 1408 YDKLEKTKTRLQQELDDLLVDLD 1430
Score = 75.5 bits (184), Expect = 3e-13
Identities = 89/418 (21%), Positives = 190/418 (45%), Gaps = 70/418 (16%)
Query: 740 IDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQ 799
+ +E+E+ +L V +N + E ETL +M E+ + + E+ Q
Sbjct: 840 VSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEK---------LQLQEQLQ 890
Query: 800 MELK---DVERKIAQQAAKLQGID-LDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQD 855
E + + E A+ AK Q ++ + ++ +E++E+ L K++ N IQ+
Sbjct: 891 AETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQN---IQE 947
Query: 856 QQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPL 915
+EQ++ +S +L+ EK+ L++ LEE+ + L + L +E K +++++
Sbjct: 948 LEEQLEEEESARQKLQLEKVTTEAKLKK---LEEEQIILEDQNCKLAKEKKLLEDRIAEF 1004
Query: 916 ETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQ 975
T L + +++ + L KN + + D++E+++ +KQ
Sbjct: 1005 TTNLTEEEEKSKSLAKLKNKHEAM----ITDLEERLRR------------------EEKQ 1042
Query: 976 KETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELK--- 1032
++ E EK + K+ D + I ++Q + + + L K+ EEL+
Sbjct: 1043 RQ-----------ELEKTRRKLEGDSTDLSDQI--AELQAQIAELKMQLAKKEEELQAAL 1089
Query: 1033 -EVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKE 1091
VEEE Q K M ++ +++S+ +L+E++++ + + N A +++ EE+ K E
Sbjct: 1090 ARVEEEAAQ--KNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTE 1147
Query: 1092 LRE------PQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEI 1143
L + Q ++ +E+ I+ +T E K ++ Q + + HS +EE+
Sbjct: 1148 LEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKT----HEAQIQEMRQKHSQAVEEL 1201
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 131 bits (329), Expect = 5e-30
Identities = 200/961 (20%), Positives = 418/961 (43%), Gaps = 136/961 (14%)
Query: 190 ETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELD 249
E LR R + + + + L++Y+ + + + ++ S E ++ KS + LD
Sbjct: 1039 EELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLD 1098
Query: 250 PLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELE---EKMEKVFQGTDEQLND 306
++KE+ KI +L EI+ R+K +E + + ++++K Q E L
Sbjct: 1099 KCYGQIKELNE---KITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGW 1155
Query: 307 LYHNHQRTVREKERKLVDCH----------RELE-KLNKESRLLNQEKSELLVE-QGRLQ 354
++ ++EKE ++ RE E +L K N+E S L + + +
Sbjct: 1156 QKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEIN 1215
Query: 355 LQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQL 414
+ +E ++ ++L QL+ E + ++ +++ ++ N L
Sbjct: 1216 ITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENAL 1275
Query: 415 MNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRI 474
E +++KQ EI L ++++ +SE ++ + L+ +Q +R+
Sbjct: 1276 QQKACGSEIMQKKQHLEIE-----LKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERL 1330
Query: 475 LELDQELIKA----ERELSKAEKNSNVETLKMEVISLQNE-KADLDRTLRKLDQEMEQLN 529
QE K E ELSK N + E +ISL+N+ + +++ T + Q Q
Sbjct: 1331 KAEFQEEAKRRWEYENELSKVRNNYDEE-----IISLKNQFETEINITKTTIHQLTMQKE 1385
Query: 530 HHTTT-RTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEIN 588
T+ R Q++ LT++ E+I+++K+ +L N +++E+ + + +
Sbjct: 1386 EDTSGYRAQIDNLTRENRSLSEEIKRLKN-------TLTQTTENLRRVEEDIQQQKATGS 1438
Query: 589 QTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGS-QDFESDLDRLKE 647
+ R +L EL Q + E+ Y+ L D + QD +++RLK+
Sbjct: 1439 EVSQRKQQLEVELRQVTQMRT----------EESVRYKQSLDDAAKTIQDKNKEIERLKQ 1488
Query: 648 EIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAEL------------- 694
I+K + R L A + L N S ++ E EL
Sbjct: 1489 LIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQE 1548
Query: 695 -----------QEVISDLQ---SKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSII 740
Q + +LQ K+ ++LK T SE K K+ +E L MR+S
Sbjct: 1549 RTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELE--GMRRS-- 1604
Query: 741 DLKEK--EIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERF 798
LKE+ +I L +L+ + +R ++D+ +Q +L + E++ + L R
Sbjct: 1605 -LKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEEL------RRL 1657
Query: 799 QMELKDVERKIAQQA-----AKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLI 853
E++ + R++ Q+ A L+ + ++ ++ E + +++ + S E K
Sbjct: 1658 SSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEH 1717
Query: 854 QDQQEQIQHLKSTTNELKSEKLQI-----STNLQRRQQLE---EQTVELSTEVQSLYREI 905
+E++++L+ ++L+ + + +T L+ R QL+ +T+EL + L RE
Sbjct: 1718 LMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRER 1777
Query: 906 KDAKEQVSPLETTLEKFQQEKEELINK----KNTSNKIAQDKLNDIKEKVKNIHGYMKDI 961
++ ++++ EKFQ++ E N+ KN ++ Q++ + K+K ++
Sbjct: 1778 ENLRQEI-------EKFQKQALEASNRIQESKNQCTQVVQER-ESLLVKIK----VLEQD 1825
Query: 962 ENYIQDGKDDYKKQKET-ELNKVIAQLSECEKHKEKINEDM-----RLMRQDIDTQKIQ- 1014
+ +Q +D+ + K T E + Q ECEK ++I D+ + R++ +KI+
Sbjct: 1826 KARLQRLEDELNRAKSTLEAETRVKQRLECEK--QQIQNDLNQWKTQYSRKEEAIRKIES 1883
Query: 1015 --ERWLQDNLTLRKRNE----ELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIK 1068
E+ ++ +LR E E+K +EE ++ L++ + Q+++E + + ID ++
Sbjct: 1884 EREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLR 1943
Query: 1069 R 1069
+
Sbjct: 1944 Q 1944
Score = 128 bits (321), Expect = 4e-29
Identities = 195/1043 (18%), Positives = 446/1043 (42%), Gaps = 107/1043 (10%)
Query: 190 ETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEI---RDQITSKEAQLTSSKEIVKS--- 243
E ++++ + +K+Y+++L E I R I S + V +
Sbjct: 945 EEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYI 1004
Query: 244 --------YENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEK 295
Y L + L++++ +KI L+ E++ + N L++ ++K
Sbjct: 1005 ELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQK 1064
Query: 296 V------FQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKE-SRL---LNQEKSE 345
F+ L +L + + ++ L C+ ++++LN++ +RL + EK
Sbjct: 1065 YQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRR 1124
Query: 346 LLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQE 405
+ R Q + + + +AR ++L Q +L+ + E +I+ L++E
Sbjct: 1125 RKSVEDRFDQQKNDYDQLQKARQCEKENLGWQ-KLESEKAIKEKEYEIERLRVLLQEEGT 1183
Query: 406 GEAKTANQLM---NDFAEK-ETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVK 461
+ + N+L N + E+ L+ K EI KT + EI +K+++ KN++
Sbjct: 1184 RKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTI-------KEISMQKEDDSKNLR 1236
Query: 462 YELQQLEGSS----DRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRT 517
+L +L + D I+ L+ +++A + +AE+N+ + K + +K L+
Sbjct: 1237 NQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQ--KACGSEIMQKKQHLEIE 1294
Query: 518 LRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLE 577
L+++ Q+ + N + +E K DK+++I ++K+ +E K+
Sbjct: 1295 LKQVMQQRSEDN--ARHKQSLEEAAKTIQDKNKEIERLKAEFQEEA----------KRRW 1342
Query: 578 DWLHSKSKEINQTRDRLAKLNKELASSEQ-NKNHINNELKRKEEQLSSYEDKLFDVCG-S 635
++ + SK N + + L + + K I+ +KEE S Y ++ ++ +
Sbjct: 1343 EYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTREN 1402
Query: 636 QDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQ 695
+ ++ RLK + ++++ + + + + V QR Q E EL+
Sbjct: 1403 RSLSEEIKRLKNTLTQTTENLRRVE----------EDIQQQKATGSEVSQRKQQLEVELR 1452
Query: 696 EVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQ 755
+V + L ++ K K + + L+ + K + + +LQ
Sbjct: 1453 QVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETN----DRKCLEDENARLQ 1508
Query: 756 NVNRDIQRLKND---------IEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVE 806
V D+Q+ + ++EQE I E S + + D I RFQ LK+++
Sbjct: 1509 RVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDIT-RFQNSLKELQ 1567
Query: 807 RKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHL--- 863
+ +Q + + L RT + + ++++ + +L+ + ++ I + +Q++
Sbjct: 1568 --LQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIV 1625
Query: 864 -KSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKF 922
K + ++L+ ++ + +L+ +Q+ +E+ LS+EV++L R++ +E V E F
Sbjct: 1626 KKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHF 1685
Query: 923 QQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKK---QKETE 979
Q+ E+ N S KI ++L + E + H +++ ++ DD ++ + +++
Sbjct: 1686 QKAIEDKSRSLNES-KIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD 1744
Query: 980 LNKVIAQL-SECEKHKEKINE------DMRLMRQDI--DTQKIQERWLQDNLTLRKRNEE 1030
N I +L S+ + + E D++ R+++ + +K Q++ L+ + +++ +
Sbjct: 1745 KNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQ 1804
Query: 1031 LKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKK 1090
+V +ER+ L ++ ++ Q K+ Q+LE+ ++ K ++ E E +
Sbjct: 1805 CTQVVQERESLLVKIKVLE--QDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQN 1862
Query: 1091 ELRE--PQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIR 1148
+L + Q+ EE R++ +E L + L I + E + +
Sbjct: 1863 DLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE----ERCRRKLE 1918
Query: 1149 DLWRSTYRGQDIEYIEIRSDADE 1171
D R T + E + + D+
Sbjct: 1919 DSTRETQSQLETERSRYQREIDK 1941
Score = 120 bits (302), Expect = 7e-27
Identities = 180/941 (19%), Positives = 392/941 (41%), Gaps = 146/941 (15%)
Query: 157 CHQEDSNWP-LSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMEL-KYLK 214
C +E+ W L KA+K+K EI E LR + Q +G + +EY+ EL K
Sbjct: 1148 CEKENLGWQKLESEKAIKEKEYEI----------ERLRVLLQEEGTRKREYENELAKVRN 1197
Query: 215 QYKEKACEIRDQI-TSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHN----LSKIMKLD 269
Y E+ +R++ T T+ KEI E++ L+N+L + +I++L+
Sbjct: 1198 HYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLN 1257
Query: 270 NEIKALDSRKKQMEKD-------NSELEEK---MEKVFQGTDEQLNDLYHNHQRTVREKE 319
+ I ++++ E++ SE+ +K +E + +Q ++ H++++ E
Sbjct: 1258 DSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAA 1317
Query: 320 RKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRAR-DSLIQSLATQL 378
+ + D ++E+E+L E + E+ + + + + +R D I SL Q
Sbjct: 1318 KTIQDKNKEIERLKAEFQ-----------EEAKRRWEYENELSKVRNNYDEEIISLKNQF 1366
Query: 379 ELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTG 438
E + N K T +QL E + + QID + +
Sbjct: 1367 ETE------------INITKT----------TIHQLTMQKEEDTSGYRAQIDNLTRENRS 1404
Query: 439 LGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVE 498
L I+ L++ L+ V+ ++QQ + + + + Q+L R++++ +V
Sbjct: 1405 LSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVR 1464
Query: 499 TLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSR 558
+ D +T++ ++E+E+L T +D+ + ++++ +
Sbjct: 1465 --------YKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQK 1516
Query: 559 HSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRK 618
+ T + NK ++++ +E+ + R ++++E +Q+ N LK
Sbjct: 1517 ANSSATETI----NKLKVQE------QELTRLRIDYERVSQERTVKDQDITRFQNSLKEL 1566
Query: 619 EEQLSSYEDKLF--------DVCGSQDFESDLD----RLKEEIEKSSKQRAMLAGATAVY 666
+ Q E++L D C + E +L+ LKE+ K + L A+ V
Sbjct: 1567 QLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVK 1626
Query: 667 SQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRR 726
+ L + + +T+ EL+ + S++++ R +L + +K+ R
Sbjct: 1627 KRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRR----QLLQEQESVKQAHLRN 1682
Query: 727 DEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIM---PEEE 783
+ + + ++ + EI L++ +N+ ++ L+ ++ + E +
Sbjct: 1683 EHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEAD 1742
Query: 784 SAKVCLTDVTIME-RFQMELKDVERKIAQQAAKLQGI--DLDRTVQQVNQEKQEKQHKLD 840
S K + TI+E R Q+++ + + +LQG+ DL R + + QE ++ Q +
Sbjct: 1743 SDK----NATILELRSQLQISN------NRTLELQGLINDLQRERENLRQEIEKFQKQAL 1792
Query: 841 TVSSKIELNR-----------------KLIQDQQEQIQHLKSTTNELKSEKLQISTNLQR 883
S++I+ ++ K+++ + ++Q L+ N KS L+ T +++
Sbjct: 1793 EASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKST-LEAETRVKQ 1851
Query: 884 RQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDK 943
R + E+Q ++ ++ K Q S E + K + E+E+ +KN+ +
Sbjct: 1852 RLECEKQQIQ---------NDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERL 1902
Query: 944 LNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQ--------LSECEKHKE 995
+IK + ++D Q + + + + E++K+ + +ECE +
Sbjct: 1903 QAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVD 1962
Query: 996 KINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEE 1036
+R+ + ++ E L D TL K + K VEE
Sbjct: 1963 TSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEE 2003
Score = 39.7 bits (91), Expect = 0.019
Identities = 143/799 (17%), Positives = 293/799 (36%), Gaps = 116/799 (14%)
Query: 227 ITSKEAQLTSSKEIVKS---YENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQME 283
+ S E + S + I S Y +LD +K L+E + +N +KA R +
Sbjct: 211 LASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLR 270
Query: 284 KDNSELEEKMEKVFQGTDEQLNDLYHN---HQRTVREKERKLVDCHRELEKLNKESRLLN 340
+ + ++ ++ D + +L ++ + +K+ +LE KE L
Sbjct: 271 QLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLK 330
Query: 341 QEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLV 400
QE +L++ Q + + + + ++ + S I + +++ E + +
Sbjct: 331 QESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAA--------YFQFF 382
Query: 401 RERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNV 460
E Q EA L + +K DK L ++E E L K++ ++
Sbjct: 383 EEAQSTEAYLKG-LQDSIRKKYPC---------DKNMPLQHLLEQIKE-LEKEREKILEY 431
Query: 461 KYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRK 520
K ++Q L S +I++L +N + + K ++ + + + K
Sbjct: 432 KRQVQNLVNKSKKIVQL-------------KPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
Query: 521 LDQ-----EMEQLNHHTTTRTQMEMLTKD--------KADKDEQIRKIKSRHSDELTSLL 567
D+ E+ + T ++ML + KI+ + L
Sbjct: 479 GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
Query: 568 GYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYED 627
+ N K L W H +I + R K + + K + EL +E +S
Sbjct: 539 QLYINMKSLVSW-HYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGS 597
Query: 628 KLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDE---NQSCCPV- 683
++F + D +++ + + K L Y Q T T E + +C V
Sbjct: 598 EMFG-------DDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVN 650
Query: 684 CQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLK 743
+V +T E + + + +L+ +++ E + K L L S
Sbjct: 651 HNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKN------LPLADQGSS----- 699
Query: 744 EKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELK 803
I N+L++V D Q + + + + +L E K C + FQ +L+
Sbjct: 700 -HHITVKINELKSVQNDSQAIAEVLNQLKDMLANFRGSE---KYCYLQNEVFGLFQ-KLE 754
Query: 804 DVE-------RKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQ 856
++ + A LQ I + +V + + ++ + K+E R
Sbjct: 755 NINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRC----- 809
Query: 857 QEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLE 916
++ +K+ N KS + T LQ+ QQ+ QT +Q +
Sbjct: 810 --GLKKIKNDLNLKKSLLATMKTELQKAQQIHSQT-----------------SQQYPLYD 850
Query: 917 TTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIE---NYIQDGK---D 970
L KF ++ +L ++ +K +L D+++++K + Y + + ++ D K D
Sbjct: 851 LDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQD 910
Query: 971 DYKKQKETELNKVIAQLSE 989
+ K + N V+ L+E
Sbjct: 911 SLESMKFGDSNTVMRFLNE 929
Score = 37.7 bits (86), Expect = 0.073
Identities = 79/428 (18%), Positives = 168/428 (39%), Gaps = 52/428 (12%)
Query: 661 GATAVYSQFITQLTDENQS--CCPVCQRVFQTEAELQEVISD-----LQSKLRLAPDKLK 713
G + +Y +TD+N C Q + +QE++ + ++++L + P+ LK
Sbjct: 36 GTSRMYYSRRGVITDQNSDGYCQTGTMSRHQNQNTIQELLQNCSDCLMRAELIVQPE-LK 94
Query: 714 STESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQET 773
+ + + DE + I+D +E+ ++ + + +L+ +
Sbjct: 95 YGDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYK 154
Query: 774 LLGTIMPEEESAK-----VCLTDVTIMERFQMELKDVERKIAQQAAKLQ----GIDLDRT 824
+ S+K C + E + + + QQ A++ G+DL
Sbjct: 155 AISVPRVRRASSKGGGGYTCQSGSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASV 214
Query: 825 VQQVNQEKQ------EKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQIS 878
Q +N + + + +LD + + + + Q ++E LK++ + + L+
Sbjct: 215 EQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERM--DHLRQL 272
Query: 879 TNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNK 938
N+ + E + E + LY D ++ + + E F +L K+ NK
Sbjct: 273 QNIIQATSREIMWINDCEEEELLY----DWSDKNTNIAQKQEAFSIRMSQLEVKEKELNK 328
Query: 939 IAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKIN 998
+ Q+ + V N H IE Y+ + + I Q+++C K N
Sbjct: 329 LKQES----DQLVLNQHPASDKIEAYMDTLQTQWSW---------ILQITKCIDVHLKEN 375
Query: 999 EDMRLMRQDIDTQKIQERWLQD----------NLTLRKRNEELKEVEEERKQHLKEMGQM 1048
++ + + + LQD N+ L+ E++KE+E+ER++ L+ Q+
Sbjct: 376 AAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQV 435
Query: 1049 QVLQMKSE 1056
Q L KS+
Sbjct: 436 QNLVNKSK 443
Score = 37.4 bits (85), Expect = 0.095
Identities = 74/395 (18%), Positives = 158/395 (40%), Gaps = 53/395 (13%)
Query: 744 EKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELK 803
+ E+ L KL+N+N N + LL I+ E+ KV +T E ++L
Sbjct: 743 QNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLD 802
Query: 804 DVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHL 863
VE A + ++++ + K+ L T+ ++++ +++ +Q
Sbjct: 803 KVE---AYRCG----------LKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLY 849
Query: 864 KSTTNELKSEKLQISTNLQR-RQQLEEQTVELSTEVQSL--YRE--------IKDAKEQV 912
+ + Q++ QR +Q++ + +L +++ L YR+ + DAK +
Sbjct: 850 DLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQ 909
Query: 913 SPLET-------TLEKFQQEKE----ELINKKNTS---NKIAQDKLNDIKEKVKNIHGYM 958
LE+ T+ +F E++ E+ K++ S KIA+ N IK+ + Y
Sbjct: 910 DSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYT 969
Query: 959 KDIENYIQ--------DGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDT 1010
+E + Q+ +++ +L + +M +D+
Sbjct: 970 SGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKL 1029
Query: 1011 QKIQERWLQDNLTL-RKRNEE----LKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENID 1065
+ + L++ L L R N E K +++ +++ E Q + E K + +D
Sbjct: 1030 KNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELD 1089
Query: 1066 --NIKRNHNLALGRQKGYEEEIIHFKKELREPQFR 1098
+ K+N + G+ K E+I E+ + + R
Sbjct: 1090 GKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRR 1124
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 131 bits (329), Expect = 5e-30
Identities = 194/960 (20%), Positives = 405/960 (42%), Gaps = 121/960 (12%)
Query: 125 EKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATR 184
EK SL + E+ R + + NV E L K+LK D +
Sbjct: 1369 EKKSLECEVEELHRTVQKRQQQKDFIDGNV-----ESLMTELEIEKSLKHHEDIVDEIEC 1423
Query: 185 YIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSY 244
K L R + + + E + EL K+ + A E + T +K +
Sbjct: 1424 IEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVE----------KFTDAKRSLLQT 1473
Query: 245 ENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEE---KMEKVFQGTD 301
E++ + L+ R +E NL +K D ++++L + K +E+ + EE ++ K+ D
Sbjct: 1474 ESDAEELERRAQETAVNL---VKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKD 1530
Query: 302 EQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQA---- 357
L ++ E ++ D E+ + N++ L ++SE+L++ R +L+
Sbjct: 1531 SDFQCLSKKKEKLTEELQKLQKDI--EMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQ 1588
Query: 358 -----------DRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEG 406
DR H + L+Q Q + D E E ++ +RE
Sbjct: 1589 VTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIRE---- 1644
Query: 407 EAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEIL-------SKKQNELKN 459
L+ + + ++ QI E + + T + + IE + E L SK + ELKN
Sbjct: 1645 ----VKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKN 1700
Query: 460 VKYELQQLEGSSDRILELDQELIKAERELSK-AEKNSNVETLKMEVISLQNEKADLDRTL 518
+ ++ QLE + L+L + +E E ++ A +E ++ IS Q +K +++
Sbjct: 1701 I-LDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQIS-QQQKGEIEWQK 1758
Query: 519 RKLDQEMEQLNHHTTT----RTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKK 574
+ L+++ ++ T ++ +E L+K+K D E+ + + + L N K
Sbjct: 1759 QLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSK 1818
Query: 575 QLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCG 634
+ L + + + L +LN++ S + + + +L+ K E ++S +++L +V
Sbjct: 1819 MEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANV-- 1876
Query: 635 SQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQ------RVF 688
+ L+ K+++ ++K + +L + I++ + + C + +V
Sbjct: 1877 ----QDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVL 1932
Query: 689 QTEAE---------------LQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLV 733
Q E E LQ+ +SKL + LK + +L+K+ + L V
Sbjct: 1933 QNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQV 1992
Query: 734 PMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLL----GTIMPEEESAKVCL 789
+ + + + + E +++ + + + K + E+E L G ++ ++ A
Sbjct: 1993 LSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMR 2052
Query: 790 TDVTIME-RFQMELKDVERKIA--QQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKI 846
D +++ +F E K E+++A ++A K+Q L++ + + QE Q ++ T I
Sbjct: 2053 ADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMAT----I 2108
Query: 847 ELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIK 906
EL + QD E+ + L N+++ E ++ + ++ LE + +E+S +++L E+K
Sbjct: 2109 EL---VAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVK 2165
Query: 907 D------------AKEQVSPLETTLEKFQQEKEELINKKN----TSNK-IAQDKLNDIKE 949
D E + LE LE+ + + EL + K T N+ ++KLN +
Sbjct: 2166 DEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQV 2225
Query: 950 KVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDID 1009
+ + H + + ++ +D K Q ++K Q K K + + +R+ +D
Sbjct: 2226 HIMDEHWRGEALREKLRHREDRLKAQLRHCMSK---QAEVLIKGKRQTEGTLHSLRRQVD 2282
Score = 119 bits (299), Expect = 1e-26
Identities = 175/910 (19%), Positives = 394/910 (43%), Gaps = 107/910 (11%)
Query: 261 NLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKER 320
N+ + L+NE+ L+ + ++ E E M + +++++ +L+HN ++EK
Sbjct: 1314 NVPEHHNLENEVSRLEDIMQHLKSKKRE-ERWMRASKRQSEKEMEELHHNIDDLLQEK-- 1370
Query: 321 KLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLEL 380
K ++C E+E+L++ + Q+K + D ++SL T+LE+
Sbjct: 1371 KSLEC--EVEELHRTVQKRQQQKDFI---------------------DGNVESLMTELEI 1407
Query: 381 DGFERGPFSERQIKNFHKLVRE---------RQEGEAKTANQLMNDFAEKETLKQKQ--- 428
E+ +K+ +V E ++ E + A++L+ + AE E K+
Sbjct: 1408 ---------EKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAE-AESELSCTKEKTK 1457
Query: 429 --IDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAER 486
+++ D K L + E+ + Q N+ QQL +L+Q IK E
Sbjct: 1458 NAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEE 1517
Query: 487 ELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQL----NHHTTTRTQMEMLT 542
L + K + + +S + EK L L+KL +++E +HH + E+L
Sbjct: 1518 ILKEINKIVAAKDSDFQCLSKKKEK--LTEELQKLQKDIEMAERNEDHHLQVLKESEVLL 1575
Query: 543 KDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELA 602
+ K + E+++ + E+ L +KK+ L + +L +
Sbjct: 1576 QAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGE--T 1633
Query: 603 SSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGA 662
+ NHI E+K E+LS + +L + ++ L +K+EIEK + ++
Sbjct: 1634 EVTEKCNHI-REVKSLLEELSFQKGELNVQISER--KTQLTLIKQEIEKEEENLQVVLRQ 1690
Query: 663 TAVYSQFITQLTD----ENQSCCPVCQRVFQTEAELQEV-ISDLQSKLRLAPDKLKSTES 717
+ + + + D EN + + Q +EL++ ++ L+ KL
Sbjct: 1691 MSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKL------------ 1738
Query: 718 ELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPEL---RNKLQNVNRDIQRLKNDIEEQETL 774
EL+ ++ + G + ++ +++ ++EI + LQ+ + + K D++E+ +
Sbjct: 1739 ELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDI 1798
Query: 775 LGTIMPEEESAKVCLTDVTIMERFQMELKDVE-RKIAQQAAKL--QGIDLDRTVQQVNQE 831
+ + + + + ME+ +E ++ RK+ Q+ +L + L + + Q+
Sbjct: 1799 WEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQ 1858
Query: 832 KQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNL----QRRQQL 887
QEK+ ++++ ++ + + ++ + H + L SE+ ++ ++ R +
Sbjct: 1859 LQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDC 1918
Query: 888 EEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQD----- 942
+++ ++Q L EI++ K ++ E ++ Q+E+E +K TS ++
Sbjct: 1919 QKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQL 1978
Query: 943 --KLNDIKEKVKNIHGYMKDIENYIQDGKDDYK--KQKETELNKVIAQLSECEKHKEKIN 998
+L D K K+ + + E ++ +++ + + E L++ QLSE E+ + +
Sbjct: 1979 EKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKS 2038
Query: 999 EDMRLMRQDIDTQKIQERWLQDN-LTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEH 1057
++ ++++ D+ + L++ LT RK+ E+ +E + + + +L+ K E+
Sbjct: 2039 GELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQEN 2098
Query: 1058 QKLEENIDNI----KRNHNLALGRQKGYEE---EIIHFKKELREPQFRDAEEKYREMMIV 1110
+++ + I + NH A K + E KK++ +D E + E+
Sbjct: 2099 SCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQ--KDLERRQMEISDA 2156
Query: 1111 MRTTELVNKD 1120
MRT + KD
Sbjct: 2157 MRTLKSEVKD 2166
Score = 118 bits (296), Expect = 3e-26
Identities = 193/1003 (19%), Positives = 424/1003 (42%), Gaps = 155/1003 (15%)
Query: 251 LKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQ---GTDEQLNDL 307
L+N + +E + + E + + + K+Q EK+ EL ++ + Q + ++ +L
Sbjct: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEEL 1380
Query: 308 YHNHQRTVREKERKLVDCHRE--LEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIR 365
+ Q+ R++++ +D + E + +L E L + E +++ E ++ + + +R
Sbjct: 1381 HRTVQK--RQQQKDFIDGNVESLMTELEIEKSLKHHE--DIVDEIECIEKTLLKRRSELR 1436
Query: 366 ARDSLIQSLATQLEL------DGFERGPFSERQI----KNFHKLVRERQE---GEAKTAN 412
D L+ ++L + E+ ++R + + +L R QE K
Sbjct: 1437 EADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQ 1496
Query: 413 QLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKS---EILSKKQ----NELKNVKYELQ 465
QL + A+ + L+Q +I + K + +I+ K + LSKK+ EL+ ++ +++
Sbjct: 1497 QLRSLQADAKDLEQHKIKQEEILKE-INKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIE 1555
Query: 466 QLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEM 525
E + D L+ + E E+ K + +E LK +V S Q E A LDR L +E+
Sbjct: 1556 MAERNEDHHLQ-----VLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEEL 1610
Query: 526 --------------------------EQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRH 559
E+ NH ++ +E L+ K + + QI S
Sbjct: 1611 HLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQI----SER 1666
Query: 560 SDELTSLLGYFPNKKQ-LEDWLHSKSK---EINQTRDRLAKLNKELASSEQNKNHINNEL 615
+LT + +++ L+ L SK E+ D L N EL + + +EL
Sbjct: 1667 KTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSEL 1726
Query: 616 KRKEEQLSSYEDKLFDVCG-SQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLT 674
++ + + + +L ++ SQ + +++ K+ +E+ ++ + + + L+
Sbjct: 1727 EKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLS 1786
Query: 675 DENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEM----L 730
E + C + A+ + V++ + ++ L+ E ++K ++ D++ L
Sbjct: 1787 KEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKL 1846
Query: 731 GL---VPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDI----EEQETLLG--TIMPE 781
L + Q + K + + L+ +L NV + K D+ + Q+ LL T + +
Sbjct: 1847 SLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQK 1906
Query: 782 ---------EESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQ------ 826
E+ K T ++ Q E+++ + K+ QQ Q + +R +
Sbjct: 1907 DISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLET 1966
Query: 827 ----------QVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQ 876
Q+ +E +++ KLD V SK+ + ++ QE+ + +S L K Q
Sbjct: 1967 SKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQ 2026
Query: 877 ISTNLQRRQQLEEQTVE---LSTEVQSL-----------YREIKDAKEQVSPLETTLEKF 922
+S +R QQL E++ E L E S+ E K A++QV+ L+ L+
Sbjct: 2027 LS---EREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQ 2083
Query: 923 QQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNK 982
+ + E+ + ++ N Q ++ I+ ++ H + + + + +Y TEL K
Sbjct: 2084 RSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEY-----TELKK 2138
Query: 983 VIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHL 1042
+A + E+ + +I++ MR ++ ++ + +L+ N+ L E+ + + L
Sbjct: 2139 QMANQKDLERRQMEISDAMRTLKSEVKD--------EIRTSLKNLNQFLPELPADLEAIL 2190
Query: 1043 KEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEI----IHFKKELREPQFR 1098
+ ++ LE ++++K N + + +EE++ +H E +
Sbjct: 2191 E------------RNENLEGELESLKENLPFTM-NEGPFEEKLNFSQVHIMDEHWRGEAL 2237
Query: 1099 DAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKME 1141
+ ++RE + + ++K ++ K Q HS++ +
Sbjct: 2238 REKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQ 2280
Score = 104 bits (260), Expect = 5e-22
Identities = 176/888 (19%), Positives = 365/888 (41%), Gaps = 151/888 (17%)
Query: 392 QIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILS 451
Q FH E EG+ T +E ++ ++E+ + L + + E+ S
Sbjct: 238 QFTIFHLRSLESLEGQPVTTQD------RQEAFERFSLEEVERLERDLEKKMIETEELKS 291
Query: 452 KKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQN-- 509
K+ L+ +K + ++ L+ + L K E K++ N+ E LK + I L
Sbjct: 292 KQTRFLEEIKNQ-----DKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRAC 346
Query: 510 -EKADLDRTLR--KLDQEMEQLNHHTTTRTQME------------------MLTKDKADK 548
++ +L++ L K+D + E LN++ + +++ T+
Sbjct: 347 QKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIID 406
Query: 549 DEQIRKIKSRHSDEL-----TSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELAS 603
Q +IK DE +L G+ P QLED K K+I+ + RL++L+ E+
Sbjct: 407 SAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLED----KEKKISAAQTRLSELHDEIEK 462
Query: 604 SEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGAT 663
+EQ E K+ EE + +++K S+ AG
Sbjct: 463 AEQQILRATEEFKQLEEAI-------------------------QLKKISE-----AGKD 492
Query: 664 AVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKE 723
+Y Q +L N+ + Q E ++++ ++ K + D L+ L K+
Sbjct: 493 LLYKQLSGRLQLVNK----LRQEALDLELQMEKQKQEIAGKQKEIKD-LQIAIDSLDSKD 547
Query: 724 KRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLL--GTIMPE 781
+ M ++ +D+ K+ +L ++L + I + +I++ E L G I
Sbjct: 548 PKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAAN 607
Query: 782 EESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDT 841
E K ++ ++ + +K + + KL+ D T+ Q E ++++ +L+
Sbjct: 608 EALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLR--DEKETLLQRLTEVEQERDQLEI 665
Query: 842 VSSKIELNRK-------LIQDQQEQIQHLKSTTNELKSEKLQISTNL--------QRRQQ 886
V+ E RK +Q+Q E L+ T +L + + ++ L Q +++
Sbjct: 666 VAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEE 725
Query: 887 LEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEK--FQQEKEELINKKNTSNKIAQDKL 944
LE+ T E +L E++ ++ L+ L K F +EKE+ ++ + K QD
Sbjct: 726 LEKVTRLTQLEQSALQAELEKERQ---ALKNALGKAQFSEEKEQENSELHAKLKHLQDDN 782
Query: 945 NDIKEKVKNIHGYMKDIENYIQDG---KDDYKKQKETELNKVIAQLSECEKH-------- 993
N +K+++K+ ++ N++ DG ++ + + K+ E H
Sbjct: 783 NLLKQQLKDFQNHL----NHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGK 838
Query: 994 -----KEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKR-----NEELKE----VEEERK 1039
+++ +E + + + D +++ER LQ+ + L++ EE ++ E R
Sbjct: 839 SLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARM 898
Query: 1040 QHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELRE----P 1095
K + ++ QM++E L+EN+ +++ L + + +EE +LRE
Sbjct: 899 NFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKK 958
Query: 1096 QFRDA----------EEKYREMMIVMRTTELVNKDLDI---YYKTLDQAIMKFHSMKMEE 1142
+ DA +E + V + +L +L I K+L +MK + + EE
Sbjct: 959 KLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEE 1018
Query: 1143 INKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLK 1190
+ + R ++ +D+ E + +N+ +++ +R+ M K
Sbjct: 1019 LQEAERFSRKAAQAARDLTRAEAEIELLQNLL---RQKGEQFRLEMEK 1063
Score = 103 bits (257), Expect = 1e-21
Identities = 192/940 (20%), Positives = 401/940 (42%), Gaps = 134/940 (14%)
Query: 187 KALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYEN 246
K +ET +++ Q + ++E + + K K KE+A + ++ L + E++K
Sbjct: 282 KMIET-EELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTI 340
Query: 247 ELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLND 306
EL + E+E L+ +D++ + + SE E + + DE
Sbjct: 341 ELTRACQKQYELEQELA--------FYKIDAKFEPLNYYPSEYAE----IDKAPDESPYI 388
Query: 307 LYHNHQRTVREKERKLVDCHR--ELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHI 364
++R + E ++D + +++K+ + +L N + L L Q + ++ I
Sbjct: 389 GKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMN--LRGHTPLDTQLEDKEKKI 446
Query: 365 RARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEG-EAKTANQLMNDFAEKET 423
A + + L ++E +E+QI + ++ +E + K ++ D K+
Sbjct: 447 SAAQTRLSELHDEIEK--------AEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQL 498
Query: 424 LKQKQ-IDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELI 482
+ Q ++++R + L +E + + ++ KQ E+K+++ + L+ + +
Sbjct: 499 SGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHM----- 553
Query: 483 KAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLT 542
KA+K+ + L + Q ++ LD L ++ +E E++ T+ ++
Sbjct: 554 -------KAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAA 606
Query: 543 KDKADKD---------EQIRKIKSRHS----------DELTSLLGYFPNKKQLEDWLHSK 583
+ KD E + IK + + DE +LL +Q D L
Sbjct: 607 NEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIV 666
Query: 584 SKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLD 643
+ + R LA EL S+ Q ++ +N L++ + LS+YE +L +D E++
Sbjct: 667 AMDAENMRKELA----ELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEAN-- 720
Query: 644 RLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQS 703
+LKEE+EK ++ + A +L E Q+ + +E + QE S+L +
Sbjct: 721 QLKEELEKVTRLTQLEQSALQA------ELEKERQALKNALGKAQFSEEKEQEN-SELHA 773
Query: 704 KLRLAPDKLKSTESELKKKEKRRDEML-GLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQ 762
KL+ D + +LK + + ++ GLV + + ELR KL+ ++
Sbjct: 774 KLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAA-----RVDELRRKLKLGTGEM- 827
Query: 763 RLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLD 822
+I +LG + + + + + ER + +++ ERK+ ++ A Q +
Sbjct: 828 ----NIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVR--ERKLQEEMALQQ----E 877
Query: 823 RTVQQVNQEKQEKQHKLDT-VSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNL 881
+ + +Q + L+ ++ + IQ + +I +L+ + E++Q T+L
Sbjct: 878 KLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSM--EEIQGLTDL 935
Query: 882 QRRQQLEEQTVELSTEVQSLYRE--IKDAK--EQVSPLETTLEKFQQEKEELINKKNTSN 937
Q Q+ +E+ + +++ L ++ ++DAK EQV L+ L+K ++ TS+
Sbjct: 936 QL-QEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVA-------TSD 987
Query: 938 KIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKI 997
K+A +L K+++K++HG + I Q+ E +L E E+ K
Sbjct: 988 KLATAELTIAKDQLKSLHGTVMKI------------NQERAE------ELQEAERFSRKA 1029
Query: 998 NEDMR-LMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSE 1056
+ R L R + + + +Q LR++ E+ + E K + QVL+++
Sbjct: 1030 AQAARDLTRAEAEIELLQN-------LLRQKGEQFR--LEMEKTGVGTGANSQVLEIEKL 1080
Query: 1057 HQKLEENIDNIKRNHN---LALGRQKGYEEEIIHFKKELR 1093
++ +E I R N L KG E ++ ELR
Sbjct: 1081 NETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELR 1120
Score = 66.2 bits (160), Expect = 2e-10
Identities = 80/413 (19%), Positives = 178/413 (43%), Gaps = 54/413 (13%)
Query: 197 QTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDP-LKNRL 255
+ + K+K Q E+ + + KE+ S+E++L +SK +K +++L+ L ++
Sbjct: 1935 EIEENKLKLVQQEMMFQRLQKERE--------SEESKLETSKVTLKEQQHQLEKELTDQK 1986
Query: 256 KEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTV 315
+++ LSK++ + ++ L ++ E +EK T QL++ ++ +
Sbjct: 1987 SKLDQVLSKVLAAEERVRTLQEEERWCES--------LEKTLSQTKRQLSE----REQQL 2034
Query: 316 REKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLA 375
EK +L+ +E + + + LL +++ L E+ + + Q +E ++ + S ++
Sbjct: 2035 VEKSGELLALQKEADSMRADFSLL---RNQFLTERKKAEKQVASLKEALKIQRSQLEKNL 2091
Query: 376 TQLELDGFERGPFSERQIKNFHKLVRERQEGEA---KTANQLMNDFAEKETLKQKQIDEI 432
L+ + ++++ + ++ E K NQ+ ++ E + Q D
Sbjct: 2092 ----LEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLE 2147
Query: 433 RDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAE 492
R + + LKSE+ + + LKN+ L +L + ILE ++ L
Sbjct: 2148 RRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENL----------- 2196
Query: 493 KNSNVETLKMEVISLQNEKADLDRTLRKLD-QEMEQLNHHTTTRTQMEMLTKDKADKDEQ 551
+E+LK + NE + KL+ ++ ++ H E L + Q
Sbjct: 2197 -EGELESLKENLPFTMNEGPFEE----KLNFSQVHIMDEHWRGEALREKLRHREDRLKAQ 2251
Query: 552 IRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASS 604
+R S+ ++ L K+Q E LHS ++++ + + + + ASS
Sbjct: 2252 LRHCMSKQAEVLIK------GKRQTEGTLHSLRRQVDALGELVTSTSADSASS 2298
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 130 bits (328), Expect = 6e-30
Identities = 275/1389 (19%), Positives = 561/1389 (40%), Gaps = 247/1389 (17%)
Query: 71 KVAQETDVRAQIRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITRTKHGEKVS-- 128
++AQ+ ++ I+ QF EL A +R ++ T + E + L + R K S
Sbjct: 100 EIAQDRNIA--IQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNT 157
Query: 129 ----LSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATR 184
L K E+ +S K + H +++ W +E LK K DE+ + R
Sbjct: 158 TKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNT-WLNTE---LKTKTDELLALGR 213
Query: 185 YI-------------KALETLRQVRQTQGQKVKEYQME------LKYLKQYKEKACEIRD 225
K E R Q G K ++ L LK+ KE+ + +
Sbjct: 214 EKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEE 273
Query: 226 QITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMK--------LDNEIKALDS 277
+ ++ + KS ++ + N L L K++K + + + ++
Sbjct: 274 KFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQ 333
Query: 278 RKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESR 337
K QMEK+ E ++EK + ++ L+ E+ + + K+ K
Sbjct: 334 SKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGM 393
Query: 338 LLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQ----- 392
L + + + Q +L L+ ++ + D +++ + + + +R + Q
Sbjct: 394 KLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVAS 453
Query: 393 ----IKNFHKLVRERQEGEAKTANQ-------------LMNDFAEKETLKQKQIDE---- 431
++ K ++ QE K Q + D +++ + +++E
Sbjct: 454 LSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGN 513
Query: 432 --IRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELS 489
IRD++ I SE++S+ +N++ ELQQ +Q L+ A REL
Sbjct: 514 HVIRDEEVS-SADISSSSEVISQHLVSYRNIE-ELQQ----------QNQRLLVALRELG 561
Query: 490 KAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKD 549
+ + ET ++ LQ L+ L +L+Q + H QM+++ +D
Sbjct: 562 ETREREEQETTSSKITELQ---LKLESALTELEQLRKSRQH------QMQLVDSIVRQRD 612
Query: 550 EQIRKIKSR--------HSDELTSL-LGYFPNKKQLEDWLHS-------KSKEINQTRDR 593
R + S+ H+ L + L P + + + +S E + +
Sbjct: 613 -MYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAA 671
Query: 594 LAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSS 653
L +L + + ++ K NE K + EQL ++++ D S ++ +++ +S
Sbjct: 672 LKQLQEIFENYKKEK--AENE-KIQNEQLEKLQEQV------TDLRSQNTKISTQLDFAS 722
Query: 654 KQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLK 713
K+ ML Y + IT L + N Q++ T + +++I+ + LR A +KL
Sbjct: 723 KRYEMLQDNVEGYRREITSLHERN-------QKLTATTQKQEQIINTMTQDLRGANEKLA 775
Query: 714 STE--SELKKKEKRRDEMLGLVPMR-------------------------QSIIDLKEKE 746
E +E KKEK EML L +R Q I++ E E
Sbjct: 776 VAEVRAENLKKEK---EMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETE 832
Query: 747 IPE-LRNKLQNVNRDIQRLK----NDIEEQET--------LLGTIMPEEESAKVCLTDVT 793
+ L ++++ + +I LK N++E++ T LL T + + L
Sbjct: 833 TKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKE 892
Query: 794 IMERFQME-------LKDVERKIAQQAAKLQG-------IDLDRTVQQVNQEKQ---EKQ 836
+++ Q E L ++E ++A Q+++ G D+D V Q+ Q ++ + +
Sbjct: 893 LLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLK 952
Query: 837 HKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNEL-KSEKLQISTNLQRRQQLEEQTVELS 895
+L T +S +E + ++ +E + K T E+ K+ ++++ + + + QLE++ +E+
Sbjct: 953 ERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVE 1012
Query: 896 TEVQSLY----REIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKV 951
E Q L R I+ ++Q+S L+ TL Q E +E + + +T+ Q D +E+
Sbjct: 1013 KEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQA 1072
Query: 952 KNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDID-- 1009
K + ++ Y E EL A + + KE++++ M +RQ ++
Sbjct: 1073 K-----------IAVEAQNKY----ERELMLHAADVEALQAAKEQVSK-MASVRQHLEET 1116
Query: 1010 TQKIQERWLQDNLTLRKRNEELKEVEEE---RKQHLKEMGQMQVLQMKSEHQKLEENI-D 1065
TQK + + L+ + +R LK+ + R + L++ ++ Q++ K+ ++ +
Sbjct: 1117 TQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKE 1176
Query: 1066 NIKRNHNLALGRQKGYEEEIIHF------KKELREPQFRDAEEK-----------YREMM 1108
++ N++L + +E+I+ +KE+ E +F A+ + RE+
Sbjct: 1177 GVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQ 1236
Query: 1109 IVMRTTELVNKDLDIYYKTLDQ------------AIMKFHSMKMEEINKIIRDLWRSTYR 1156
+ + + + + KT+ Q +M+ + M EE ++ +DL + +
Sbjct: 1237 ELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAK 1296
Query: 1157 GQDIEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLA 1216
+ +E ++I + N S+K +L+ D R A + L S
Sbjct: 1297 VRKLE-LDILPLQEANAELSEKSGMLQAEKKLLEEDVK-----RWKARNQHLVSQQKDPD 1350
Query: 1217 LAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVEL 1276
E L ++ E T ++ E + EI +S + N Q L+ + ED ++
Sbjct: 1351 TEEYRKL----LSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKV 1406
Query: 1277 LGRSEYVEK 1285
E ++K
Sbjct: 1407 RTEKETIQK 1415
Score = 127 bits (320), Expect = 5e-29
Identities = 218/1057 (20%), Positives = 440/1057 (41%), Gaps = 132/1057 (12%)
Query: 231 EAQLTSSKEIVKSYENEL---DPLKN-RLKEIEHNLSKIMKLDNEIKA-LD--SRKKQME 283
+A L +EI ++Y+ E + ++N +L++++ ++ + + +I LD S++ +M
Sbjct: 669 KAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEML 728
Query: 284 KDNSE--------LEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKE 335
+DN E L E+ +K+ T +Q + + + +R KL E L KE
Sbjct: 729 QDNVEGYRREITSLHERNQKLTATTQKQ-EQIINTMTQDLRGANEKLAVAEVRAENLKKE 787
Query: 336 SRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKN 395
+L + SE+ + Q R L A++ +++ + +Q++ LE E +R
Sbjct: 788 KEML--KLSEVRLSQQRESLLAEQRGQNLLLTN--LQTIQGILERSETET---KQRLSSQ 840
Query: 396 FHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQN 455
KL E + K N++ L + +D R T + K E+L Q
Sbjct: 841 IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTK-ELLKNAQK 899
Query: 456 ELKNVKYELQQLE----------------GSSDRILELDQELIKAERELSKAEKN----- 494
E+ +K L +E + + + +L +L + E +++ ++
Sbjct: 900 EIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTST 959
Query: 495 SNVETLKMEVISLQNEKADLDRTLRKLDQEME-QLNHHTTTRTQMEMLTKDKADKDEQIR 553
SNVE + V SL+ + ++ + +E +L +TQ+E + + ++++
Sbjct: 960 SNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQ 1019
Query: 554 KIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINN 613
K R + + ++QL + + S N+ ++ L + + L++ +Q +
Sbjct: 1020 DDKRRAIESM---------EQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQE 1070
Query: 614 ELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGAT---------- 663
+ K E + YE +L + + D E+ L KE++ K + R L T
Sbjct: 1071 QAKIAVEAQNKYEREL--MLHAADVEA-LQAAKEQVSKMASVRQHLEETTQKAESQLLEC 1127
Query: 664 -AVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDK-----LKSTES 717
A + + L DE C C+ + + L + I L K+ + + L + S
Sbjct: 1128 KASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLS 1187
Query: 718 ELKKKEKRRDEMLGLVPMRQSIIDLK----EKEIPELRNKLQNVNRDIQRLKNDI----E 769
E K +++ E+L + + I + + + E R +++ + R++Q L++ + E
Sbjct: 1188 EEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAERE 1247
Query: 770 EQETLLGTIMPEEESAKVCLTDVTIMERFQM---ELKDVERKIAQQAAKLQGIDLD-RTV 825
+ + T+ EE K T +ME +M E + +E+ + Q AK++ ++LD +
Sbjct: 1248 KVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPL 1307
Query: 826 QQVNQEKQEKQHKLDTVSSKIE--LNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQR 883
Q+ N E EK L +E + R ++Q Q T E + + + +R
Sbjct: 1308 QEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKR 1367
Query: 884 RQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDK 943
QQL E+ L E+ + + + + L+ L K + EKE T K K
Sbjct: 1368 IQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKE-------TIQKDLDAK 1420
Query: 944 LNDIKEKVKNIHGYMKDIENYIQDGKDDYK--KQKETELNKVIAQLSECEKHKEKINEDM 1001
+ DI+EKVK I K Y K Y+ K ++ ++ + AQ S + + ++M
Sbjct: 1421 IIDIQEKVKTITQVKKIGRRY----KTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEM 1476
Query: 1002 RLMRQDIDTQKIQERWLQDNL-----TLRKRNEELKEVEEERKQHLKEMGQM-QVLQMK- 1054
+ +++ ++ + + + L+ + TL ++ E + ++E+ Q E+ ++ Q LQ +
Sbjct: 1477 QELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRT 1536
Query: 1055 SEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTT 1114
++ ++L + I + A+ K + K +L + + E K R
Sbjct: 1537 TQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTK---ENEELKQR--------- 1584
Query: 1115 ELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVS 1174
N LD LD I S I+++ R+L R ++E R + E +
Sbjct: 1585 ---NGALDQQKDELDVRITALKSQYEGRISRLEREL-----REHQERHLEQRDEPQEPSN 1636
Query: 1175 ASDKRRNYNYRVVMLKGDTALDMRGRCSAGQKVLASL 1211
+++ R + LK A RG S A++
Sbjct: 1637 KVPEQQ----RQITLKTTPASGERGIASTSDPPTANI 1669
Score = 124 bits (311), Expect = 6e-28
Identities = 190/946 (20%), Positives = 392/946 (41%), Gaps = 130/946 (13%)
Query: 64 NTFVHDPKVAQETDVRAQIRLQFRDVNGELIAV--------QRSMVCTQKSKK---TEFK 112
NT D + A E A++R + E++ + + S++ Q+ + T +
Sbjct: 761 NTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQ 820
Query: 113 TLEGVITRTKHGEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCH-------------- 158
T++G++ R++ K LSS+ +++ E IS L K + N V H
Sbjct: 821 TIQGILERSETETKQRLSSQIEKLEHE-ISHL--KKKLENEVEQRHTLTRNLDVQLLDTK 877
Query: 159 ---QEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELK---- 211
++N L+ + LK EI + +++ +E QV Q+ + Q K
Sbjct: 878 RQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEV--QVASQSSQRTGKGQPSNKEDVD 935
Query: 212 ----YLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMK 267
L+Q +E+ ++++++ + + + + +V S E L+ K +E+ N+ +K
Sbjct: 936 DLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLK 995
Query: 268 LDNEIKA-LDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCH 326
E + L+ + ++EK+ EL++ + + ++QL++L E + L
Sbjct: 996 ESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRAS 1055
Query: 327 RELEKLNKESRLLNQEKSELLVE-QGRLQLQADRHQEHIRA------RDSLIQSLATQLE 379
L +++R QE++++ VE Q + + + H + A + S + S+ LE
Sbjct: 1056 TALSN-EQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLE 1114
Query: 380 LDGFERGPFSERQIKNFHKLVRERQ---EGEAKTANQLMNDFAEKETLKQKQIDEIRDK- 435
E +E Q+ ER+ + E D ++ L QI+++ DK
Sbjct: 1115 ----ETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKV 1170
Query: 436 ----KTGL-----------GRIIELKSEILS--KKQNELKNVKYELQQLEGSSDRILELD 478
K G+ G+ E EIL +++ E+ ++E+ Q+E L
Sbjct: 1171 VASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVES-----LRYR 1225
Query: 479 QELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQM 538
Q + EREL + + + N E K++V + A + ++K + + + R +
Sbjct: 1226 QRVELLERELQELQDSLNAEREKVQVTA--KTMAQHEELMKKTETMNVVMETNKMLREEK 1283
Query: 539 EMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLN 598
E L +D ++RK++ ++ L + L ++ K + + R N
Sbjct: 1284 ERLEQDLQQMQAKVRKLEL----DILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARN 1339
Query: 599 KELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAM 658
+ L S +++ + EE +K Q ++ RLK EI +S+
Sbjct: 1340 QHLVSQQKDPD--------TEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSN----- 1386
Query: 659 LAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESE 718
A+ +Q + Q E+ + + E + + DL +K+ +K+K T ++
Sbjct: 1387 ---ASLTNNQNLIQSLKEDLN---------KVRTEKETIQKDLDAKIIDIQEKVK-TITQ 1433
Query: 719 LKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTI 778
+KK +R + +LK ++ + Q+ + D Q ++E + L T+
Sbjct: 1434 VKKIGRR---------YKTQYEELKAQQDKVMETSAQS-SGDHQEQHVSVQEMQELKETL 1483
Query: 779 MPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHK 838
E +K + V +++ E + R + +Q +LQ +L R Q + +++
Sbjct: 1484 NQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQS-ELSRLRQDLQDRTTQEEQL 1542
Query: 839 LDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEV 898
++ K E RK I + +I HL ++L E ++ QR L++Q EL +
Sbjct: 1543 RQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELK---QRNGALDQQKDELDVRI 1599
Query: 899 QSLYREIKDAKEQVSPLETTLEKFQQEK-EELINKKNTSNKIAQDK 943
+L + + ++S LE L + Q+ E+ + SNK+ + +
Sbjct: 1600 TALKSQYEG---RISRLERELREHQERHLEQRDEPQEPSNKVPEQQ 1642
Score = 118 bits (296), Expect = 3e-26
Identities = 216/1100 (19%), Positives = 456/1100 (41%), Gaps = 157/1100 (14%)
Query: 239 EIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQME---KDNSELEEKMEK 295
EI K + + L N +E + ++ KL+N++KAL + K++E N ++ + +
Sbjct: 56 EIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTR 115
Query: 296 VFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQ- 354
+ + + DL ++R +E E D R EKL KES N K EL ++ LQ
Sbjct: 116 TKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKL-KES---NTTKGELQLKLDELQA 171
Query: 355 --LQADRHQEHIRARDSLIQSLATQLELD-----------GFERGPFSERQIKNFHKLVR 401
+ ++ + L+ S T L + G E+G +I K
Sbjct: 172 SDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKG----NEILEL-KCNL 226
Query: 402 ERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVK 461
E ++ E + MN QK ++++ K L E ++ + K NEL N
Sbjct: 227 ENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTK---LKEAKEQQASMEEKFHNEL-NAH 282
Query: 462 YELQQL--------EGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKAD 513
+L L E S+ + +EL K +E +A K L++E Q EK
Sbjct: 283 IKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEM 342
Query: 514 LDRTLRKLDQEMEQLNH-HTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPN 572
L++ + +L++E+E N + T+ + +L++++ ++ L +
Sbjct: 343 LEK-IGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNA 401
Query: 573 KKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDV 632
+ +D L + E + L ++ KE+ + E +R ++ ++S KL
Sbjct: 402 YVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKL--- 458
Query: 633 CGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEA 692
+ ++ RL+E+ +K++KQ ++L + L+ + + +
Sbjct: 459 ---EQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHV 515
Query: 693 ELQEVIS--DLQSKLRLAPDKLKSTES--ELKKKEKRRDEMLGLVPMRQSIIDLKEKE-- 746
E +S D+ S + L S + EL+++ +R LV +R+ + + +E+E
Sbjct: 516 IRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRL-----LVALRE-LGETREREEQ 569
Query: 747 ------IPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVT--IMERF 798
I EL+ KL++ ++++L+ + Q L+ +I+ + + ++ L+ T +
Sbjct: 570 ETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLH 629
Query: 799 QMELKDVE----------RKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIEL 848
L DV + A + I+ ++ KQ ++ + K E
Sbjct: 630 ASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAE- 688
Query: 849 NRKLIQDQQEQIQHLKSTTNELKSEKLQISTNL-------------------------QR 883
N K+ Q EQ++ L+ +L+S+ +IST L +R
Sbjct: 689 NEKI---QNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHER 745
Query: 884 RQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDK 943
Q+L T + + ++ ++++ A E+++ E E ++EKE L K + +++Q +
Sbjct: 746 NQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEML---KLSEVRLSQQR 802
Query: 944 LNDIKEK--VKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDM 1001
+ + E+ + ++ I+ ++ + + K++ +++ K+ ++S +K E E
Sbjct: 803 ESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQR 862
Query: 1002 RLMRQDIDTQKIQ-ERWLQDNLTLRKRNEE-LKEVEEE---RKQHLKEMGQMQVLQMKSE 1056
+ +++D Q + +R L L +E LK ++E KQHL M ++QV S+
Sbjct: 863 HTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNM-EVQVASQSSQ 921
Query: 1057 H-------------------QKLEENIDNIKRNHNLALGRQKGYE------EEIIHFKKE 1091
++ EE ++++K + + Y+ EE ++ +K+
Sbjct: 922 RTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQ 981
Query: 1092 LREPQFRDAEEKYRE-----------MMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKM 1140
+ E ++ E + +E +M V + + + D ++++Q + +
Sbjct: 982 VTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLS 1041
Query: 1141 EEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGR 1200
N++ L R++ + + + R D E + + +N R +ML A D+
Sbjct: 1042 SVQNEVQEALQRASTALSNEQ--QARRDCQEQAKIAVEAQNKYERELMLH---AADVEAL 1096
Query: 1201 CSAGQKVLASLIIRLALAET 1220
+A ++V +R L ET
Sbjct: 1097 QAAKEQVSKMASVRQHLEET 1116
Score = 95.5 bits (236), Expect = 3e-19
Identities = 171/836 (20%), Positives = 360/836 (43%), Gaps = 97/836 (11%)
Query: 279 KKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRL 338
+ ++ K ++ K+EK +++ L H++ E E++ + + L + + RL
Sbjct: 11 RTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLS--HSQERL 68
Query: 339 LNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHK 398
+N+ + E L+L+ ++ ++A + +LE+ +R I +
Sbjct: 69 VNETR-----ECQSLRLELEKLNNQLKA----LTEKNKELEI-------AQDRNIAIQSQ 112
Query: 399 LVRERQEGEAK-----TANQLMNDFAEKETLKQKQIDE-IRDKKTGLGRIIELKSEILSK 452
R ++E EA+ N+ ++ E T K+++E +++ T G ++LK L +
Sbjct: 113 FTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGE-LQLK---LDE 168
Query: 453 KQNELKNVKYELQQLEGSSDRILE----LDQELIKAERELSKAEKNSNVETLKMEVISLQ 508
Q +VKY ++LE + + L+ EL EL + E L+++ +L+
Sbjct: 169 LQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELK-CNLE 227
Query: 509 NEKADLDRTLRKLDQEMEQL---NHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTS 565
N+K ++ R L+++M L N H + ++LTK K K++Q ++ + +EL +
Sbjct: 228 NKKEEVSR----LEEQMNGLKTSNEHLQKHVE-DLLTKLKEAKEQQ-ASMEEKFHNELNA 281
Query: 566 LLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSY 625
+ K D +KS E+ + + L KL KE + E NK I + L E+
Sbjct: 282 HIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKE--AGEANK-AIQDHLLEVEQSKDQM 338
Query: 626 EDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQ 685
E ++ + G RL++E+E ++ + A+ S+ +
Sbjct: 339 EKEMLEKIG---------RLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIV 389
Query: 686 RVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEK 745
+ EL + Q +L L + K L + K + ++ ++ + +K
Sbjct: 390 KPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQK 449
Query: 746 EIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMER-FQMELKD 804
+ L KL+ ++IQRL+ D ++ + + ++ + D++ R MEL++
Sbjct: 450 AVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEE 509
Query: 805 VERKIAQQAAKLQGIDLDRTVQQVNQ--------EKQEKQHKLDTVSSKIELNRKLIQDQ 856
+ ++ D+ + + ++Q E+ ++Q++ V+ + EL +++
Sbjct: 510 ARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALR-ELGETREREE 568
Query: 857 QEQIQHLKSTTNELKSEK-LQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPL 915
QE K T +LK E L L++ +Q + Q V+ + +YR + Q + +
Sbjct: 569 QETTSS-KITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRIL---LSQTTGV 624
Query: 916 ETTLEKFQQEKEELIN---KKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDY 972
L + L + + +TS ++ + E + I K +Q+ ++Y
Sbjct: 625 AIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEA--KAALKQLQEIFENY 682
Query: 973 KKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQ----KIQERWLQDNL------ 1022
KK+K E K+ Q + EK +E++ D+R I TQ + LQDN+
Sbjct: 683 KKEK-AENEKI--QNEQLEKLQEQVT-DLRSQNTKISTQLDFASKRYEMLQDNVEGYRRE 738
Query: 1023 --TLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKL---EENIDNIKRNHNL 1073
+L +RN++L ++++Q + M Q ++ ++KL E +N+K+ +
Sbjct: 739 ITSLHERNQKLTATTQKQEQIINTMTQ----DLRGANEKLAVAEVRAENLKKEKEM 790
Score = 80.5 bits (197), Expect = 1e-14
Identities = 139/676 (20%), Positives = 284/676 (42%), Gaps = 105/676 (15%)
Query: 521 LDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSD-ELTSLLGYFPNKKQLEDW 579
L Q +E+ + ++ L K AD+ +I +K RH ++ S YF +K+L
Sbjct: 5 LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLS-- 62
Query: 580 LHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELK---RKEEQLSSYEDKLFDVCGSQ 636
HS+ + +N+TR E S +NN+LK K ++L +D+ +
Sbjct: 63 -HSQERLVNETR--------ECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAI---- 109
Query: 637 DFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQE 696
+S R KEE+E + L SQ + LT++ +R+ + E
Sbjct: 110 --QSQFTRTKEELEAEKRD---LIRTNERLSQELEYLTED-------VKRLNEKLKESNT 157
Query: 697 VISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSII--DLKEK--------- 745
+LQ KL D+L++++ +K +EKR ++ L+ + + + +LK K
Sbjct: 158 TKGELQLKL----DELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGR 213
Query: 746 ----EIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQME 801
EI EL+ L+N ++ RL +E + G E K +E +
Sbjct: 214 EKGNEILELKCNLENKKEEVSRL------EEQMNGLKTSNEHLQK-------HVEDLLTK 260
Query: 802 LKDVERKIAQQAAKLQGIDLDRTVQQVNQEK---QEKQHKLDTVSSKIELNRKLIQDQQE 858
LK+ + + A K +L+ ++ N K + + K + ++ +E KL+++ E
Sbjct: 261 LKEAKEQQASMEEKFHN-ELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGE 319
Query: 859 QIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYRE-----IKDAKEQVS 913
+ ++ E++ K Q+ + + E+ +E + ++ S + ++ +S
Sbjct: 320 ANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMS 379
Query: 914 PLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYK 973
P + K + +L N + QD+L K + K I+ Y+ +I ++ K
Sbjct: 380 PTAAAVAKIVKPGMKLTELYNAYVE-TQDQLLLEKLENKRINKYLDEIVKEVEAKAPILK 438
Query: 974 KQKE-------------TELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQD 1020
+Q+E +L + + ++ ++ +K N+ ++ +D +IQ + L
Sbjct: 439 RQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQ 498
Query: 1021 NLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKG 1080
+ + L E+EE R H+ ++ + S + + +++ + + L Q+
Sbjct: 499 QIRVL-----LMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQR- 552
Query: 1081 YEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKM 1140
++ +EL E + R+ +E + TEL K L+ L+Q + K +M
Sbjct: 553 ----LLVALRELGETREREEQETTSS-----KITELQLK-LESALTELEQ-LRKSRQHQM 601
Query: 1141 EEINKIIRDLWRSTYR 1156
+ ++ I+R R YR
Sbjct: 602 QLVDSIVRQ--RDMYR 615
Score = 73.6 bits (179), Expect = 1e-12
Identities = 115/529 (21%), Positives = 230/529 (43%), Gaps = 76/529 (14%)
Query: 683 VCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDL 742
V Q+V + EL ++ +Q+KL L +SE+ + R ++ V Q ++
Sbjct: 4 VLQQVLE-RTELNKLPKSVQNKLEKF---LADQQSEIDGLKGRHEKFK--VESEQQYFEI 57
Query: 743 KEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLT-DVTIMERF--- 798
EK + + +L N R+ Q L+ ++E+ L + + + ++ ++ I +F
Sbjct: 58 -EKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRT 116
Query: 799 ----QMELKDVERKIAQQAAKLQGID-----LDRTVQQVNQEKQEKQHKLDTVSS----- 844
+ E +D+ R + + +L+ + L+ +++ N K E Q KLD + +
Sbjct: 117 KEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSV 176
Query: 845 -----KIELNRKLIQDQQEQIQ-HLKSTTNELKS-------EKLQISTNLQRRQQ----L 887
++E ++L+ Q + LK+ T+EL + E L++ NL+ +++ L
Sbjct: 177 KYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRL 236
Query: 888 EEQTVELSTE-------VQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIA 940
EEQ L T V+ L ++K+AKEQ + +E EKF E I N A
Sbjct: 237 EEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASME---EKFHNELNAHIKLSNLYKSAA 293
Query: 941 QD---KLNDIKEKVKNIHGYMK---DIENYIQDGKDDYKKQKETELNKVIAQLSECEKHK 994
D K N++ V+ +H +K + IQD + ++ K+ +++ ++ EK
Sbjct: 294 DDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKEL 353
Query: 995 EKINEDMRLMRQD--IDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQ 1052
E N+ + ++ I +++ + K + ++ E +++ Q Q+L
Sbjct: 354 ENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVET--QDQLLL 411
Query: 1053 MKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMR 1112
K E++++ + +D I + K EE +K + + E+ +E+ +
Sbjct: 412 EKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVK-LEQAMKEIQRLQE 470
Query: 1113 TTELVNKD----------LDIYYKTLDQAIMKFHSMKMEEI--NKIIRD 1149
T+ NK ++I K L Q I + M++EE N +IRD
Sbjct: 471 DTDKANKQSSVLERDNRRMEIQVKDLSQQI-RVLLMELEEARGNHVIRD 518
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 129 bits (323), Expect = 2e-29
Identities = 185/926 (19%), Positives = 403/926 (43%), Gaps = 104/926 (11%)
Query: 217 KEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDN-----E 271
+E+ + D + + AQ S ++ E+EL ++ ++E+ L ++ +
Sbjct: 135 REEEFGVDDSYSEQGAQ--DSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQ 192
Query: 272 IKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEK 331
++ ++ KQ + ++L +++ + DE + + + E+ +KL + ++
Sbjct: 193 LQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE-----LTEQSQKL---QIQFQQ 244
Query: 332 LNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSER 391
L L N S + + + Q HQ+ + +D L++ + E D + F +
Sbjct: 245 LQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKE-DFTMQISFLQE 303
Query: 392 QIKNFHKLVRERQEGEAKTANQLMNDFAEKETL----------KQKQIDEIRDKKTGLGR 441
+IK + E + K N + EKET+ ++K+ E++DK T +
Sbjct: 304 KIKVYE------MEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADK 357
Query: 442 II-ELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETL 500
++ EL+ +I+ K Q E+KN+K EL + + E ++L+ EL K N +
Sbjct: 358 LLGELQEQIVQKNQ-EIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQK----RNHKDS 412
Query: 501 KMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHS 560
+ E +Q + + R L +L E++++ + + E++ + A Q+ ++K+RH
Sbjct: 413 QFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMA----QMEEMKTRHK 468
Query: 561 DELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEE 620
E+ + L + N ED + + IN+ LN +L + K + EL E
Sbjct: 469 GEMENALRSYSNITVNEDQIKLMNVAINE-------LNIKLQDTNSQKEKLKEELGLILE 521
Query: 621 QLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSC 680
+ + + +L +D +L +E+I+++ + A + ++ + D
Sbjct: 522 EKCALQRQL------EDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575
Query: 681 CPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSII 740
+ + E + + +++ + KL + + + + + ++ E L R ++
Sbjct: 576 VSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERL-----RTQLL 630
Query: 741 DLKEKEIPELRNKLQNVNR-DIQRLKNDI----EEQETLLGTIMPEEESAKVCLTDVTIM 795
E+E+ +L+ L+ +R +I++LK+++ ++Q L M ++ D I
Sbjct: 631 FSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLIT 690
Query: 796 ERFQM-----ELKDVERKIAQQAAK---LQGIDLDRTVQQVNQEKQEK---QHKLDTVSS 844
++ Q+ +LKD+++ + ++ LQ +L + ++ + QE++EK + ++ +
Sbjct: 691 KQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQL 750
Query: 845 KIELNRKLIQ----DQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQS 900
K EL K ++ D QE+ L++ + LK EK + L+ +S E +
Sbjct: 751 KTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIH-------TPVSQEERL 803
Query: 901 LYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIH-GYMK 959
++ + +K + S E +E +E E+L + N+ + + N KN Y +
Sbjct: 804 IFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQE 863
Query: 960 DIENY-----IQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDI------ 1008
E Y ++D +D K ++E E + L+E E H ++IN M+ +
Sbjct: 864 LQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNE-ELHLQRINPTTVKMKSSVFDEDKT 922
Query: 1009 ---DTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENID 1065
+T ++ E +D L ++ E K + E Q L ++ + Q+ Q E L E +
Sbjct: 923 FVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSE-QLKQKHGEISFLNEEVK 981
Query: 1066 NIKRNHNLALGRQKGYEEEIIHFKKE 1091
++K+ R + E I H + E
Sbjct: 982 SLKQEKEQVSLRCRELEIIINHNRAE 1007
Score = 124 bits (312), Expect = 5e-28
Identities = 202/960 (21%), Positives = 419/960 (43%), Gaps = 133/960 (13%)
Query: 166 LSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRD 225
+++ + +++ F + AT +K E LR+ + + ++ +EL + + D
Sbjct: 1873 VTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYA---D 1929
Query: 226 QITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMK----LDNEIKALDSRKKQ 281
+ T E Q+ +I+ E EL NRL+E+E +I + L + +A+ +
Sbjct: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGP 1989
Query: 282 ME-----------KDNSELEEKMEKVFQGTDEQLNDLYHNHQRTV-------REKERKLV 323
+E K+ E++ + EKV +Q+ L + + V +EK +L+
Sbjct: 1990 VEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELM 2049
Query: 324 DCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLE-LDG 382
D ++ + L K+ + + E +++ H+ + ++ IQ L QL+ +
Sbjct: 2050 DLRQQNQALEKQLEKMRKFLDEQAIDR--------EHERDVFQQE--IQKLEQQLKVVPR 2099
Query: 383 FERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLG-R 441
F+ P SE Q + +L +E K + L++ KE L Q+ I E ++ L R
Sbjct: 2100 FQ--PISEHQTREVEQLANHLKEKTDKCSELLLS----KEQL-QRDIQERNEEIEKLEFR 2152
Query: 442 IIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQEL-IKAERELSKAEKNSNVETL 500
+ EL+ +L K E ++ G+ + EL E+ ++AER+ + K + L
Sbjct: 2153 VRELEQALLVSADT---FQKVEDRKHFGAVEAKPELSLEVQLQAERD-AIDRKEKEITNL 2208
Query: 501 KMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQ------IRK 554
+ ++ + E + + +++L ++E +TTR Q E+ ++K KD+ I++
Sbjct: 2209 EEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQ-ELEQENKLFKDDMEKLGLAIKE 2267
Query: 555 IKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQN-----KN 609
+ + + L G F + K EI+Q +++ KL ++L + N KN
Sbjct: 2268 SDAMSTQDQHVLFGKF------AQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKN 2321
Query: 610 HINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQF 669
+ +L+ + E L S ++ C ++ E ++++L E IEK ++ A + T++ +
Sbjct: 2322 ELIRDLETQIECLMSDQE-----CVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAH- 2375
Query: 670 ITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEM 729
L++E S V + L++ + ++ + LK T K + E+
Sbjct: 2376 --SLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNF---KMNQLTQEL 2430
Query: 730 LGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCL 789
L R+S+ K + IPE +VN I L D E E +L E A L
Sbjct: 2431 FSLKRERESV--EKIQSIPE-----NSVNVAIDHLSKDKPELEVVL------TEDALKSL 2477
Query: 790 TDVTIMERFQMELK----DVERKIAQQAAKLQGIDLDRT--VQQVNQEKQEKQHKLDTVS 843
+ T + F+ K ++E ++ Q + + DL+ T +Q+ +++ Q + + +
Sbjct: 2478 ENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQ 2537
Query: 844 SKIELNRKLIQDQ-------QEQIQHLKSTTNELKSEKLQIS----TNLQRRQQLEEQTV 892
KI +K+++++ Q Q++ ++ + + S TN+Q QL E
Sbjct: 2538 KKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED-- 2595
Query: 893 ELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVK 952
EL +++ +L I + + QV + T+L ++E+ E+ K ++ EK K
Sbjct: 2596 ELGSDISALTLRISELESQVVEMHTSL-ILEKEQVEIAEK-------------NVLEKEK 2641
Query: 953 NIHGYMKDIENYIQDGKDDYKKQ--KETELNKVIAQLSECEKHKEKINEDMRLMRQDIDT 1010
+ K +E + ++ KK+ ++ E+ K +L + NE L + + T
Sbjct: 2642 KLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVAT 2701
Query: 1011 Q------KIQERWLQDNLTLRKRN-EELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEEN 1063
+ K + LQ+ L +++ N L++ + + HL E + + K + +++E+
Sbjct: 2702 KAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQES 2761
Score = 122 bits (306), Expect = 2e-27
Identities = 202/1044 (19%), Positives = 446/1044 (42%), Gaps = 137/1044 (13%)
Query: 229 SKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSE 288
++E L S + + E L+ + ++EH +K+ + E+ R+KQ ++ +
Sbjct: 1839 NEELMLNISSRLQAAVEKLLEAISETSSQLEH--AKVTQ--TELMRESFRQKQEATESLK 1894
Query: 289 LEEKMEKVFQGTDEQLNDLYHNHQRTVRE--KERKLVDCHRELEKL-----NKESRLLNQ 341
+E++ E+L++ ++ E K ++D + + + L +++ ++++
Sbjct: 1895 CQEELR-------ERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDR 1947
Query: 342 EKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVR 401
+ ELL RLQ + + Q+ I+ L L+ Q E E GP ++ ++ KL++
Sbjct: 1948 LEQELLCASNRLQ-ELEAEQQQIQEEREL---LSRQKEAMKAEAGPVEQQLLQETEKLMK 2003
Query: 402 ERQEGEAKTANQLMNDFAEKETLKQKQIDEIR-DKKTGLGRIIELKSEILSKKQNELKNV 460
E+ E + + A ++ +D QKQ+ + D + + R IEL+ E K EL ++
Sbjct: 2004 EKLEVQCQ-AEKVRDDL-------QKQVKALEIDVEEQVSRFIELEQE----KNTELMDL 2051
Query: 461 KYELQQLEGSSDRILE-LDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLR 519
+ + Q LE +++ + LD++ I E E ++ ++ L+ ++ + + + R
Sbjct: 2052 RQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQE--IQKLEQQLKVVPRFQPISEHQTR 2109
Query: 520 KLDQEMEQLNHHTTTRTQM----EMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQ 575
+++Q L T +++ E L +D +++E+I K++ R + +LL ++
Sbjct: 2110 EVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQK 2169
Query: 576 LEDWLH----------SKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSY 625
+ED H S ++ RD + + KE+ + E+ EL+ K E++
Sbjct: 2170 VEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQL 2229
Query: 626 E-----DKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSC 680
K Q+ E + K+++EK A+ D++
Sbjct: 2230 HMQLEIQKKESTTRLQELEQENKLFKDDMEKLG---------LAIKESDAMSTQDQHVLF 2280
Query: 681 CPVCQRVFQTEAE---LQEVISDLQSKLRLAPD-KLKSTESELKKKEKRRDEMLGLVPMR 736
Q + + E E L E ++ LQ +L++ D K+ ++EL + + + E L + +
Sbjct: 2281 GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECL--MSDQ 2338
Query: 737 QSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIME 796
+ + +E+EI +L ++ + +++ +I ++ ++ + EE + DV I E
Sbjct: 2339 ECVKRNREEEIEQLNEVIEKLQQELA----NIGQKTSMNAHSLSEEADSLKHQLDVVIAE 2394
Query: 797 RF----QMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQ--HKLDTV-------- 842
+ Q+E + E + K +++ Q++ K+E++ K+ ++
Sbjct: 2395 KLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVA 2454
Query: 843 -----SSKIELNRKLIQDQQEQIQ---HLKSTTNELKSEKLQISTNLQRRQQLEEQTVEL 894
K EL L +D + ++ + KS K + + T L QLE
Sbjct: 2455 IDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLL---QLESTVSAK 2511
Query: 895 STEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNI 954
E+ Y++IKD +EQ L+K ++++ +K + ++Q +L ++E K
Sbjct: 2512 DLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAK-- 2569
Query: 955 HGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQ 1014
+ QD + + + T + + QL E +++ D+ + I + Q
Sbjct: 2570 ---------FCQDNQTISSEPERTNIQN-LNQLRE-----DELGSDISALTLRISELESQ 2614
Query: 1015 ERWLQDNLTLRKRNEELKE---VEEERK----QHLKEMGQMQVLQMKSEHQKLEENIDNI 1067
+ +L L K E+ E +E+E+K Q L E + + Q + E ++ ++++ +
Sbjct: 2615 VVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKK--QREKEKKRSPQDVEVL 2672
Query: 1068 KRNHNL-ALGRQKGYEEEIIHFKKE-----LREPQFRDAEEKYREMMIVMRTT-ELVNKD 1120
K L + G+ E+ + E +++ EK +E ++V T + KD
Sbjct: 2673 KTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKD 2732
Query: 1121 LDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIE-IRSDADENVSASDKR 1179
L L +A K ++ E+ ++ + I+ + I S D + S
Sbjct: 2733 LSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSS- 2791
Query: 1180 RNYNYRVVMLKGDTALDMRGRCSA 1203
N ++++ ++++ CS+
Sbjct: 2792 -NQTPQILVKNAGIQINLQSECSS 2814
Score = 105 bits (262), Expect = 3e-22
Identities = 148/707 (20%), Positives = 306/707 (43%), Gaps = 121/707 (17%)
Query: 476 ELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTR 535
EL Q L+++ + E + E L + + S +A +++ L + + QL H T+
Sbjct: 1820 ELSQRLVRSG--FAGTEIDPENEELMLNISS--RLQAAVEKLLEAISETSSQLEHAKVTQ 1875
Query: 536 TQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLA 595
T E++ + K E +K + ++L + LH +S+ Q L+
Sbjct: 1876 T--ELMRESFRQKQEATESLKCQ---------------EELRERLHEESRAREQLAVELS 1918
Query: 596 KLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGS---QDFESDLDRLKEEIEKS 652
K + K +++ K + + E +L +C S Q+ E++ +++EE E
Sbjct: 1919 KAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL--LCASNRLQELEAEQQQIQEERELL 1976
Query: 653 SKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKL 712
S+Q+ + Q + Q T++ + + + + + ++V DLQ ++
Sbjct: 1977 SRQKEAMKAEAGPVEQQLLQETEK------LMKEKLEVQCQAEKVRDDLQKQV------- 2023
Query: 713 KSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQE 772
K+ E +++++ R + + Q K E+ +LR + Q + + +++++ ++EQ
Sbjct: 2024 KALEIDVEEQVSR------FIELEQE----KNTELMDLRQQNQALEKQLEKMRKFLDEQ- 2072
Query: 773 TLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRT--VQQVNQ 830
I E E + FQ E++ +E+++ + + Q I +T V+Q+
Sbjct: 2073 ----AIDREHER-----------DVFQQEIQKLEQQL-KVVPRFQPISEHQTREVEQLAN 2116
Query: 831 EKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLE-- 888
+EK K + E ++ IQ++ E+I+ L+ EL+ L + Q+ + +
Sbjct: 2117 HLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHF 2176
Query: 889 ---EQTVELSTEVQ---------SLYREIKDAKEQVSPLETTLEKFQQEKEEL-----IN 931
E ELS EVQ +EI + +EQ+ LE +E ++L I
Sbjct: 2177 GAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQ 2236
Query: 932 KKNTS---------NKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGK-DDYKKQKETELN 981
KK ++ NK+ +D + + +K M + ++ GK ++KE E++
Sbjct: 2237 KKESTTRLQELEQENKLFKDDMEKLGLAIKESDA-MSTQDQHVLFGKFAQIIQEKEVEID 2295
Query: 982 KVIAQLSECEKH-----KEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEE----LK 1032
++ Q+++ ++ K+ E+ + +D++TQ E + D +++ EE L
Sbjct: 2296 QLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQ--IECLMSDQECVKRNREEEIEQLN 2353
Query: 1033 EVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYE-------EEI 1085
EV E+ +Q L +GQ + S L E D++K ++ + + E EE+
Sbjct: 2354 EVIEKLQQELANIGQKTSMNAHS----LSEEADSLKHQLDVVIAEKLALEQQVETANEEM 2409
Query: 1086 IHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAI 1132
K L+E F+ + +E+ + R E V K I +++ AI
Sbjct: 2410 TFMKNVLKETNFK-MNQLTQELFSLKRERESVEKIQSIPENSVNVAI 2455
Score = 102 bits (253), Expect = 3e-21
Identities = 189/978 (19%), Positives = 406/978 (41%), Gaps = 114/978 (11%)
Query: 211 KYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDN 270
K L + +E+ + +I + + +LT+SK+ + E+ L ++E++ K + +
Sbjct: 357 KLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFET 416
Query: 271 EIKALDSRKKQMEKDNSELEEKMEKVF-QGTDEQLNDLYHNHQRTVRE-KERKLVDCHRE 328
+I + +++ ++ +L ++++++ Q + +L H + E K R +
Sbjct: 417 DI--VQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENA 474
Query: 329 LEKLNK------ESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDG 382
L + + +L+N +EL ++ Q ++ +E + +L QLE D
Sbjct: 475 LRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLE-DL 533
Query: 383 FERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRI 442
E FS QI+ + + E QE + A+ K + + D K +
Sbjct: 534 VEELSFSREQIQRARQTIAE-QESKLNEAH--------------KSLSTVEDLKAEIVSA 578
Query: 443 IELKSEILSKKQNELKNVKYELQQLEGSSDRIL---------ELD----QELIKAERELS 489
E + E+ K + E+ N K +L+ LE + +L EL+ Q L E ELS
Sbjct: 579 SESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELS 638
Query: 490 KAEKNSNVETLKMEVISLQNE-----KADLDRTLRKLDQEME--QLNHHTTTRTQMEMLT 542
K +++ +E ++ + L++ K +D ++ Q++E Q Q +++
Sbjct: 639 KLKEDLEIEH-RINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLIL 697
Query: 543 KDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLE-DWLHSKSKEINQTRDRLAKLNKEL 601
+ KD Q + S+ S+E+T + N+ Q E + L + KE + +L +
Sbjct: 698 EISKLKDLQQSLVNSK-SEEMTLQI----NELQKEIEILRQEEKEKGTLEQEVQELQLKT 752
Query: 602 ASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAG 661
E+ N+L+ K QL + L D + ++ D LK S ++R +
Sbjct: 753 ELLEKQMKEKENDLQEKFAQLEAENSILKD-----EKKTLEDMLKIHTPVSQEERLIFLD 807
Query: 662 A------TAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKST 715
+ +V+ + I L +EN+ C +L E I ++ A +
Sbjct: 808 SIKSKSKDSVWEKEIEILIEENEDLKQQC-------IQLNEEIEKQRNTFSFAEKNFEVN 860
Query: 716 ESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQ---------RLKN 766
EL ++E L+ ++ + D K K+ E ++KL+ +N ++ ++K+
Sbjct: 861 YQEL------QEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKS 914
Query: 767 DIEEQ------ETL-LGTIMPEEESAKVCLTDVTIMERFQM--ELKDVERKIAQQAAKLQ 817
+ ++ ETL +G ++ ++ + + +VT E+ ++ L D+ ++ Q+ ++
Sbjct: 915 SVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEIS 974
Query: 818 GIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNR-KLIQDQQEQIQHLKSTTNELKSEKLQ 876
L+ V+ + QEK++ + + I NR + +Q Q+ L + S +
Sbjct: 975 --FLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAE 1032
Query: 877 ISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTS 936
S + + EE + + +V + + +Q + L +E + + +
Sbjct: 1033 GSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSEN 1092
Query: 937 NKIAQDKLNDIKEKVKNIHGYMKD----IENYIQDGKDDYKKQKETELNKVIAQLSE--C 990
+K+ Q +LN +K + ++ M+ + D ++ E E +K + L E
Sbjct: 1093 DKL-QKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELI 1151
Query: 991 EKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKE----MG 1046
+EKI E ++ + ++ T K QE + + K V EE L+ +G
Sbjct: 1152 FAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLG 1211
Query: 1047 QMQVLQMKSE--HQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKY 1104
+ +K E + E + D I N + L + Y E+ F++ + + EE
Sbjct: 1212 EYYTPALKCEVNAEDKENSGDYISENEDPEL---QDYRYEVQDFQENMHTLLNKVTEEYN 1268
Query: 1105 REMMIVMRTTELVNKDLD 1122
+ +++ R +++ + D
Sbjct: 1269 KLLVLQTRLSKIWGQQTD 1286
Score = 79.7 bits (195), Expect = 2e-14
Identities = 206/998 (20%), Positives = 428/998 (42%), Gaps = 157/998 (15%)
Query: 187 KALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYEN 246
K + L+++ + + Q++L+ +++Y K C+ +Q S E + T+ + + + E+
Sbjct: 2538 KKIVNLQKIVEEKVAAALVSQIQLEAVQEYA-KFCQ-DNQTISSEPERTNIQNLNQLRED 2595
Query: 247 EL----DPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDE 302
EL L R+ E+E S+++++ +L K+Q+E + EK +K+ +
Sbjct: 2596 ELGSDISALTLRISELE---SQVVEMHT---SLILEKEQVEIAEKNVLEKEKKLLE---- 2645
Query: 303 QLNDLYHNHQRTVREKERK-------LVDCHRELEKLNKESRLLNQ------EKSELLVE 349
L L +++ REKE+K ++ EL N+ES N+ E E
Sbjct: 2646 -LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAE 2704
Query: 350 QGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAK 409
+ +A++ QE + +++ + SL L R +E + K ++ + E E +
Sbjct: 2705 LASYKEKAEKLQEELLVKETNMTSLQKDLSQ---VRDHLAEAKEKL--SILEKEDETEVQ 2759
Query: 410 TANQ----------LMNDFAEKE--TLK---QKQIDEIRDKKTGLGRIIELKSEILSKKQ 454
+ + L A + TLK Q +I K G+ I L+SE S++
Sbjct: 2760 ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ--INLQSECSSEEV 2817
Query: 455 NELKNVKYE----LQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNE 510
E+ + E +Q+L + IL+++ I +E E K E V+ LK E +L
Sbjct: 2818 TEIISQFTEKIEKMQELHAAE--ILDMESRHI-SETETLKREHYVAVQLLKEECGTL--- 2871
Query: 511 KADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSD--------E 562
KA + K + +L H +T+ + +D + I S+ D E
Sbjct: 2872 KAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEE 2931
Query: 563 LTSLLGYFPNK-KQLEDWLHSKSKEINQTRDRLAKLNKELASS-------EQNKNHINNE 614
S FP K K L +H++ ++ + ++ + E+ K +IN
Sbjct: 2932 SESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTI 2991
Query: 615 LKRKE---EQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFIT 671
K+ + E +++D SQ ES D E + + Q+ L + + + F T
Sbjct: 2992 SSLKDLITKMQLQREAEVYD--SSQSHESFSDWRGELL--LALQQVFLEERSVLLAAFRT 3047
Query: 672 QLT-----DENQSCCPVCQRVFQTEAELQEVISDLQ--------SKLRLAPDKLKSTESE 718
+LT D + QR+ + E Q + LQ S+++ ++ +
Sbjct: 3048 ELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKIT 3107
Query: 719 LKKK---EKRRDEMLGL-VPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETL 774
LK++ EK E+L + +QS + + E+ ++++ + + K + E ++
Sbjct: 3108 LKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSE 3167
Query: 775 LG-TIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQ 833
L T + E + K + +E F++E+KD ++ L+ T+ ++ +
Sbjct: 3168 LAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHL---------LNDTLASEQKKSR 3218
Query: 834 EKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVE 893
E Q L+ K +L R +D++E ++ LK + K LQ++ L++++QL ++ +
Sbjct: 3219 ELQWALE--KEKAKLGRSEERDKEE-LEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQ 3275
Query: 894 LSTEVQSLY-REIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVK 952
+ LY ++ + + + L+ LE S K+ +++ ++ +
Sbjct: 3276 KIESQRMLYDAQLSEEQGRNLELQVLLE---------------SEKVRIREMSSTLDRER 3320
Query: 953 NIHGYMKDIENYIQ--------DGKDDYKKQKETELNKVIAQLSECEKHK-------EKI 997
+H ++ + Q D + +KQ E + ++++ L+E EK+K +++
Sbjct: 3321 ELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQM 3380
Query: 998 NEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEH 1057
+D ++ R+ + T++ + N +K+ EL+ E+ ++ L+E Q QV ++ E
Sbjct: 3381 EKDRQVHRKTLQTEQ------EANTEGQKKMHELQSKVEDLQRQLEEKRQ-QVYKLDLEG 3433
Query: 1058 QKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREP 1095
Q+L+ + ++ L R++ E I + + L EP
Sbjct: 3434 QRLQGIMQEFQKQE---LEREEKRESRRILY-QNLNEP 3467
Score = 76.3 bits (186), Expect = 2e-13
Identities = 178/958 (18%), Positives = 383/958 (39%), Gaps = 125/958 (13%)
Query: 195 VRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNR 254
V QT+ K+ Q + L+ +E + + S +Q+T+ ++I +++++L L++
Sbjct: 1272 VLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDL 1331
Query: 255 LKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHN---- 310
K KL+ +++ L+S +++ E E+ E ++L + +
Sbjct: 1332 EKT---------KLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPP 1382
Query: 311 ----HQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRA 366
+ E + + K N + + + + E ++L ++QE +
Sbjct: 1383 SLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEE 1442
Query: 367 RD-----SLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQE--GEAKTANQLMNDFA 419
S+ + A Q EL G + K H + ++ Q E K + + F
Sbjct: 1443 EVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIG-FQ 1501
Query: 420 EKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQ 479
ET+ K +E + LG E EIL + + S D +L + +
Sbjct: 1502 TFETVDVKFKEEFKPLSKELG---EHGKEILLSNSDP--------HDIPESKDCVLTISE 1550
Query: 480 ELIKAER----------ELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLN 529
E+ ++ E+S + +++ + + E L++ + +L R ++ Q E L
Sbjct: 1551 EMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEE-QLEDMRQELVRQYQEHQQATELLR 1609
Query: 530 HHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQ 589
QME +D+ E+I+++ +QL ++ +
Sbjct: 1610 Q--AHMRQMERQREDQEQLQEEIKRLN-----------------RQLAQRSSIDNENLVS 1650
Query: 590 TRDRLAKLNKELASSEQ----NKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRL 645
R+R+ L +EL + +Q + + EL+ Q + + +V E +LDR
Sbjct: 1651 ERERV--LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708
Query: 646 KEEI--EKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVIS---- 699
E++ E S +R L A N + V +T A ++E I
Sbjct: 1709 PEDVPPEILSNERYALQKA--------------NNRLLKILLEVVKTTAAVEETIGRHVL 1754
Query: 700 ---DLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELR-NKLQ 755
D SK + + + +E+E K +E + +SI ++P N
Sbjct: 1755 GILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTD--ESIPSYSGSDMPRNDINMWS 1812
Query: 756 NVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAK 815
V + L + I PE E + I R Q ++ + I++ +++
Sbjct: 1813 KVTEEGTELSQRLVRSGFAGTEIDPENEELML-----NISSRLQAAVEKLLEAISETSSQ 1867
Query: 816 LQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKL 875
L+ + +T + + + ++KQ +++ + EL +L ++ + + Q EL +
Sbjct: 1868 LEHAKVTQT-ELMRESFRQKQEATESLKCQEELRERLHEESRAREQ----LAVELSKAEG 1922
Query: 876 QISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNT 935
I + E Q E + + L +E+ A ++ LE ++ Q+E+E L +K
Sbjct: 1923 VIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEA 1982
Query: 936 SNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQ---KETELNKVIAQLSECEK 992
A + ++ + + +++ + +DD +KQ E ++ + +++ E E+
Sbjct: 1983 MKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ 2042
Query: 993 HKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVL- 1051
K D+R Q ++ Q + R D + + +E ++V ++ Q L++ Q++V+
Sbjct: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHE--RDVFQQEIQKLEQ--QLKVVP 2098
Query: 1052 --QMKSEHQ--KLEENIDNIKRN----HNLALGRQKGYEEEIIHFKKELREPQFRDAE 1101
Q SEHQ ++E+ +++K L L +++ + +I +E+ + +FR E
Sbjct: 2099 RFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQ-LQRDIQERNEEIEKLEFRVRE 2155
Score = 68.9 bits (167), Expect = 3e-11
Identities = 200/996 (20%), Positives = 408/996 (40%), Gaps = 154/996 (15%)
Query: 202 KVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHN 261
++ E Q E++ L+Q +++ + ++ +E QL + + L+ ++KE E++
Sbjct: 720 QINELQKEIEILRQEEKEKGTLEQEV--QELQL------------KTELLEKQMKEKEND 765
Query: 262 L-SKIMKLDNEIKALDSRKKQME---KDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVRE 317
L K +L+ E L KK +E K ++ + ++ +F L+ + + +V E
Sbjct: 766 LQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF------LDSIKSKSKDSVWE 819
Query: 318 KERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQ 377
KE +++ E E L ++ LN+E +E+ R + ++ L + A
Sbjct: 820 KEIEIL--IEENEDLKQQCIQLNEE-----IEKQRNTFSFAEKNFEVNYQE-LQEEYACL 871
Query: 378 LELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKT 437
L++ ++++++ KL +E + N T+K K + KT
Sbjct: 872 LKVKDDLEDSKNKQELEYKSKLKALNEELHLQRIN--------PTTVKMKS-SVFDEDKT 922
Query: 438 GLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNV 497
+ +E+ E++ K EL +++LE + LEL Q L +L +K+ +
Sbjct: 923 FVAETLEM-GEVVEKDTTEL------MEKLEVTKREKLELSQRLSDLSEQLK--QKHGEI 973
Query: 498 ETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQM----------EMLTKDKAD 547
L EV SL+ EK + R+L+ +NH+ Q ++T
Sbjct: 974 SFLNEEVKSLKQEKEQVSLRCRELE---IIINHNRAENVQSCDTQVSSLLDGVVTMTSRG 1030
Query: 548 KDEQIRKIKSRHSDELTSLLGYFPNKKQLEDW-LHSKSKEINQTRDRLAKLNKELASSEQ 606
+ + K+ +E ++ +K E+ + +SK+ D L + KE +S
Sbjct: 1031 AEGSVSKVNKSFGEESKIMV---EDKVSFENMTVGEESKQEQLILDHLPSVTKE-SSLRA 1086
Query: 607 NKNHINNELKRKEEQLSSYEDKL------FDVCGSQDFESDLDRLKEEIEKSSKQRAMLA 660
+ N++L+++ L S ++ L +C S + + +D+++E +E +
Sbjct: 1087 TQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSL 1146
Query: 661 GATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEV--ISDLQSKLRLAPDKL-KSTES 717
+++Q + Q++ Q E + + D L L KL K+
Sbjct: 1147 KEELIFAQ---------EEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSE 1197
Query: 718 ELKKKEKRRDEMLG--LVPMRQSIIDLKEKE-----IPELRN-KLQNVNRDIQRLKNDIE 769
E + +LG P + ++ ++KE I E + +LQ+ ++Q + E
Sbjct: 1198 ECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQ---E 1254
Query: 770 EQETLLGTIMPEEESAKVCLTDVTIMERFQ---MELKDVERKIAQQAAKLQGIDLDRTVQ 826
TLL + E V T ++ + Q M+L+ E + ++ + I Q
Sbjct: 1255 NMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIH----SQ 1310
Query: 827 QVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSE-----KLQISTNL 881
N E + HK +SS +L + +++Q ++++ L S+ + E + +I
Sbjct: 1311 MTNLEDIDVNHK-SKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQ 1369
Query: 882 QRRQQLEEQTVELSTEVQSLYREIKDAKEQVSP-------LETTLEKFQQE---KEELIN 931
+R Q + E TV S V S+ DA+ + P ++ T+E F E KEE N
Sbjct: 1370 KRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIE-FSGEFGVKEE-TN 1427
Query: 932 KKNTSNKIAQDKLNDIKEKV---KNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLS 988
K Q++L + KV +I + + I GK++ K+ +
Sbjct: 1428 IVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH--------A 1479
Query: 989 ECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQM 1048
C++ + NE M+L + I Q + + K EE K + +E +H KE
Sbjct: 1480 VCQQEQHYFNE-MKLSQDQIGFQTFETVDV-------KFKEEFKPLSKELGEHGKE---- 1527
Query: 1049 QVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMM 1108
+L S+ + E+ D + L + + +++ ++ + + + + R++M
Sbjct: 1528 -ILLSNSDPHDIPESKDCV-----LTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLM 1581
Query: 1109 IVMRTTELVNKDLDIYYKTLDQA---IMKFHSMKME 1141
+ E + ++L Y+ QA + + H +ME
Sbjct: 1582 LNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQME 1617
Score = 68.6 bits (166), Expect = 4e-11
Identities = 167/863 (19%), Positives = 339/863 (39%), Gaps = 127/863 (14%)
Query: 166 LSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMEL---------KYLKQY 216
L EG KQ+ E + + ++ L+T ++ + + ++E L Y
Sbjct: 2649 LLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASY 2708
Query: 217 KEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEH---------------- 260
KEKA ++++++ KE +TS ++ + + L K +L +E
Sbjct: 2709 KEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFE 2768
Query: 261 ----NLSKIM--KLDNEIKALDSRKK----------QMEKDNSELEEKMEKVFQGTDEQL 304
LSK + + D +K S + Q+ + E++ ++ E++
Sbjct: 2769 PLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKI 2828
Query: 305 NDLYHNHQRTVREKERKLVDCHRELEKLNKES----RLLNQEKSELLVEQGRLQ------ 354
+ H + + E + + E E L +E +LL +E L L+
Sbjct: 2829 EKMQELHAAEILDMESRHIS---ETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSS 2885
Query: 355 ----LQADRHQ-EHIRARDS---------LIQSLATQLELDGFERGPFSERQIKNFHKLV 400
+D +Q I + DS L S + +G RG SE +F K +
Sbjct: 2886 IPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEG--RGEESESATDSFPKKI 2943
Query: 401 RERQEGEAKTANQLM----NDFAEKETLKQKQIDE--IRDKKTGLGRIIELKSEILSKKQ 454
+ Q++ + +++ E +Q+ E + ++K + I LK ++++K Q
Sbjct: 2944 KGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLK-DLITKMQ 3002
Query: 455 NELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADL 514
+ + Y+ Q S + + EL+ A +++ E++ + + E+ +L D
Sbjct: 3003 LQREAEVYDSSQ---SHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGT--TDA 3057
Query: 515 DRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKK 574
L L+Q +++ Q M KAD+ + +I++ H+ + ++
Sbjct: 3058 VGLLNCLEQRIQEQG----VEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQE 3113
Query: 575 QLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCG 634
+ I Q + ++ ++ EL+S + + +EQLSS +K+
Sbjct: 3114 SEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL-------QEQLSS--EKMV---- 3160
Query: 635 SQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAEL 694
+ +S+L + K E+E + K + + + TDE + T A
Sbjct: 3161 VAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDE-------VHLLNDTLASE 3213
Query: 695 QEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKL 754
Q+ +LQ L +K K SE + KE+ D L +Q + L L +
Sbjct: 3214 QKKSRELQ--WALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLL----LEQQK 3267
Query: 755 QNVNRDIQRLKNDIEEQETLLGTIMPEEE----SAKVCLTDVTIMERFQMELKDVERKIA 810
Q +N Q+ IE Q L + EE+ +V L + R D ER++
Sbjct: 3268 QLLNESQQK----IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELH 3323
Query: 811 QQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKI-ELNRKLIQDQQEQIQHLKSTTNE 869
Q G R +E Q +L+ S+I EL + + + + +Q + +
Sbjct: 3324 AQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKD 3383
Query: 870 LKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQ------ 923
+ + + T + + +++ EL ++V+ L R++++ ++QV L+ ++ Q
Sbjct: 3384 RQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEF 3443
Query: 924 QEKEELINKKNTSNKIAQDKLND 946
Q++E +K S +I LN+
Sbjct: 3444 QKQELEREEKRESRRILYQNLNE 3466
Score = 65.1 bits (157), Expect = 4e-10
Identities = 140/695 (20%), Positives = 289/695 (41%), Gaps = 117/695 (16%)
Query: 440 GRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVET 499
GR I LK E S+K ++ + ++Y +QQ + ++LE+ EL + ++ ++ + E
Sbjct: 3103 GRKITLKREQESEKPSQ-ELLEYNIQQKQS---QMLEMQVELSSMKDRATELQEQLSSE- 3157
Query: 500 LKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRH 559
KM V L K++L +T +L+ ++ + H + KDK D+ +
Sbjct: 3158 -KMVVAEL---KSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLL------- 3206
Query: 560 SDELTSLLGYFPNKKQLE-DWLHSKSK-----EINQTRDRLAKLNKELASSEQNKNHINN 613
+D L S KK E W K K + ++ L L L S +Q +N
Sbjct: 3207 NDTLAS-----EQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNL 3261
Query: 614 ELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQL 673
L+++++ L+ + K+ SQ D +L EE ++ + + +L + + L
Sbjct: 3262 LLEQQKQLLNESQQKI----ESQRMLYDA-QLSEEQGRNLELQVLLESEKVRIREMSSTL 3316
Query: 674 TDENQSCCPVCQRVFQTEAELQEVISDLQSKLRL-APDKLKSTESELKKKEKRRDEMLGL 732
E + A+LQ QS+ L + D LK + +L++K R
Sbjct: 3317 DRERE-----------LHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSR------- 3358
Query: 733 VPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDV 792
I EL N+ + D + + +E+ + + E+ A
Sbjct: 3359 --------------IVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANT--EGQ 3402
Query: 793 TIMERFQMELKDVERKIAQQAAKLQGIDLD-RTVQQVNQEKQEKQHKLDTVSSKIELNRK 851
M Q +++D++R++ ++ ++ +DL+ + +Q + QE Q+++ + + K E R
Sbjct: 3403 KKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE---EKRESRRI 3459
Query: 852 LIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQ 911
L Q+ E T++ ++ LQ + ++ + +E++ E++ +++
Sbjct: 3460 LYQNLNEPTTW-SLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQK 3518
Query: 912 VSPLETTLEKFQQEKEELINKKNTSNKI---AQDKLNDIKEKVKNIHGYMKDIENYIQDG 968
+ + + L+ Q+ E + + ++ Q+ +++I +++ + G + + +
Sbjct: 3519 LQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3578
Query: 969 KD-----DYKKQKETELNKVIAQLSECEKHK-----EKINEDMRLMRQD----------- 1007
+ ++ EL I+QL+E EK+ K+ E +R RQ
Sbjct: 3579 TSCGSLTERLLRQNAELTGHISQLTE-EKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3637
Query: 1008 ----------IDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEH 1057
I ++K E W ++ LTL+K + + + K L+ +Q L SEH
Sbjct: 3638 LNGGANIEAIIASEK--EVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEH 3695
Query: 1058 QKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKEL 1092
L KR + L R + + + +I+ KK L
Sbjct: 3696 VTL-------KRIYGKYL-RAESFRKALIYQKKYL 3722
Score = 59.7 bits (143), Expect = 2e-08
Identities = 109/507 (21%), Positives = 222/507 (43%), Gaps = 68/507 (13%)
Query: 805 VERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQ-EQIQHL 863
V+ ++Q A+ D ++ + E KQH+++ ++ ++E R + +Q+Q
Sbjct: 141 VDDSYSEQGAQ----DSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEF 196
Query: 864 KSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQ 923
++ + Q++ NLQ+ ++ +++T+ RE + EQ L+ +FQ
Sbjct: 197 EAAIKQRDGIITQLTANLQQARREKDETM----------REFLELTEQSQKLQI---QFQ 243
Query: 924 QEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKV 983
Q + + +T + A D L K+++ +++ ++ ++D Y+K+KE +
Sbjct: 244 QLQASETLRNSTHSSTAADLLQ-AKQQILTHQQQLEEQDHLLED----YQKKKE-DFTMQ 297
Query: 984 IAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEEL--KEVEEERKQ- 1040
I+ L E K K+ E M QD + + +Q+ T+ EEL K +EEE+K
Sbjct: 298 ISFLQE----KIKVYE----MEQDKKVENSNKEEIQEKETII---EELNTKIIEEEKKTL 346
Query: 1041 HLKE-MGQMQVLQMKSEHQKLEEN--IDNIKRNHNLALGRQKGYEEEIIHFKKELREPQF 1097
LK+ + L + + Q +++N I N+K + +++ EEI + E Q
Sbjct: 347 ELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQK 406
Query: 1098 RDAEEKYREMMIVMRTTELVNKDLDIYYKTLD-----------QAIMKFHSMKMEEINKI 1146
R+ ++ E IV R + + L+ LD Q +++ H +MEE+
Sbjct: 407 RNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTR 466
Query: 1147 IRDLWRSTYRGQDIEYIEIRSDADE----NVSASD---KRRNYNYRVVMLKGDTALDMRG 1199
+ + R Y I + D+ NV+ ++ K ++ N + LK + L +
Sbjct: 467 HKGEMENALR----SYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEE 522
Query: 1200 RCSAGQKVLASLIIRLALA-ETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQ 1258
+C A Q+ L L+ L+ + E IA E N +++ ++ EI+ +
Sbjct: 523 KC-ALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASES 581
Query: 1259 QRNFQLLVITHDEDFVELLGRSEYVEK 1285
++ +L H+ + + E +EK
Sbjct: 582 RKELEL---KHEAEVTNYKIKLEMLEK 605
Score = 51.2 bits (121), Expect = 6e-06
Identities = 196/1039 (18%), Positives = 414/1039 (39%), Gaps = 144/1039 (13%)
Query: 176 FDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLT 235
FDE T + LE V + + +++ ++ + + ++ ++ +Q+ K +++
Sbjct: 917 FDE--DKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEIS 974
Query: 236 SSKEIVKSYENELDPLKNRLKEIE----HNLSK-IMKLDNEIKAL--------------- 275
E VKS + E + + R +E+E HN ++ + D ++ +L
Sbjct: 975 FLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGS 1034
Query: 276 --DSRKKQMEKDNSELEEKM--EKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEK 331
K E+ +E+K+ E + G + + L +H +V ++ E +K
Sbjct: 1035 VSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDK 1094
Query: 332 LNKESRLLNQEKSELLVEQGRLQLQADR---------HQEHIR-----ARDSLIQSLATQ 377
L KE +L E+++L RLQ++A R H + +R +D + SL +
Sbjct: 1095 LQKELNVLKSEQNDL-----RLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEE 1149
Query: 378 LELDGFERGPFSERQIKNFHKL----VRERQEG-EAKTANQLMNDFAEKETLKQKQIDEI 432
L E+ ++++ H+L ++ ++ G E K + L+ + + + +
Sbjct: 1150 LIFAQEEK----IKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQT 1205
Query: 433 RDKKTGLGRIIELKSEILSK-KQN-----------ELKNVKYELQQLEGSS----DRILE 476
G LK E+ ++ K+N EL++ +YE+Q + + +++ E
Sbjct: 1206 LCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTE 1265
Query: 477 LDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRT 536
+L+ + LSK + +K+E + L K + E ++ T
Sbjct: 1266 EYNKLLVLQTRLSKI-WGQQTDGMKLEF---------GEENLPKEETEFLSIHSQMTNLE 1315
Query: 537 QMEMLTKDKADKDEQIRKIK-SRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLA 595
+++ K K + + K K EL SL+ ++QL++ + EI+ + RL
Sbjct: 1316 DIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSL--QQQLKETEQNYEAEIHCLQKRLQ 1373
Query: 596 KLNKELASSEQNKNHINNELKRKEEQLSSYEDKLF--DVCGSQDFESDLDRLKEE----- 648
+++ + + + + Q + Y ++ G+ +F + +KEE
Sbjct: 1374 AVSESTVPPSLPVDSV--VITESDAQRTMYPGSCVKKNIDGTIEFSGEFG-VKEETNIVK 1430
Query: 649 -IEKSSKQRAMLAGATAVYSQFI-----TQLT-----DENQSCCPVCQRVFQTEAELQEV 697
+EK +++ A + S I T+L+ EN + V Q E Q
Sbjct: 1431 LLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQE---QHY 1487
Query: 698 ISDLQ-SKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQN 756
++++ S+ ++ ++ + + K++ K + LG + + +IPE ++ +
Sbjct: 1488 FNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLT 1547
Query: 757 VNRDI-QRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAK 815
++ ++ + K I Q + ++++ + + +E + EL + Q
Sbjct: 1548 ISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQEL------VRQYQEH 1601
Query: 816 LQGIDLDRTVQQVNQEKQ-EKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEK 874
Q +L R E+Q E Q +L + LNR+L Q ++L S + E+
Sbjct: 1602 QQATELLRQAHMRQMERQREDQEQLQEEIKR--LNRQLAQRSSIDNENLVSERERVLLEE 1659
Query: 875 LQI--STNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQE--KEELI 930
L+ +L R++L + ST+ Q+ + +EQ E L++ ++ E L
Sbjct: 1660 LEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFK-EKELDRKPEDVPPEILS 1718
Query: 931 NKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKD-DYKKQKETEL---NKVIAQ 986
N++ K L + E VK + I ++ D K Q L ++ A
Sbjct: 1719 NERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEAS 1778
Query: 987 LSEC--EKHKEKINEDM------RLMRQDIDT-QKIQERWLQDNLTLRKRNEELKEVEEE 1037
+ C E+H +E + + R DI+ K+ E + + L + E++ E
Sbjct: 1779 VKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPE 1838
Query: 1038 RKQHLKEMGQM------QVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKE 1091
++ + + ++L+ SE E+ + RQK E + ++E
Sbjct: 1839 NEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEE 1898
Query: 1092 LREPQFRDAEEKYREMMIV 1110
LRE E + RE + V
Sbjct: 1899 LRERLHE--ESRAREQLAV 1915
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 129 bits (323), Expect = 2e-29
Identities = 185/926 (19%), Positives = 403/926 (43%), Gaps = 104/926 (11%)
Query: 217 KEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDN-----E 271
+E+ + D + + AQ S ++ E+EL ++ ++E+ L ++ +
Sbjct: 135 REEEFGVDDSYSEQGAQ--DSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQ 192
Query: 272 IKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEK 331
++ ++ KQ + ++L +++ + DE + + + E+ +KL + ++
Sbjct: 193 LQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE-----LTEQSQKL---QIQFQQ 244
Query: 332 LNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSER 391
L L N S + + + Q HQ+ + +D L++ + E D + F +
Sbjct: 245 LQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKE-DFTMQISFLQE 303
Query: 392 QIKNFHKLVRERQEGEAKTANQLMNDFAEKETL----------KQKQIDEIRDKKTGLGR 441
+IK + E + K N + EKET+ ++K+ E++DK T +
Sbjct: 304 KIKVYE------MEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADK 357
Query: 442 II-ELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETL 500
++ EL+ +I+ K Q E+KN+K EL + + E ++L+ EL K N +
Sbjct: 358 LLGELQEQIVQKNQ-EIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQK----RNHKDS 412
Query: 501 KMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHS 560
+ E +Q + + R L +L E++++ + + E++ + A Q+ ++K+RH
Sbjct: 413 QFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMA----QMEEMKTRHK 468
Query: 561 DELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEE 620
E+ + L + N ED + + IN+ LN +L + K + EL E
Sbjct: 469 GEMENALRSYSNITVNEDQIKLMNVAINE-------LNIKLQDTNSQKEKLKEELGLILE 521
Query: 621 QLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSC 680
+ + + +L +D +L +E+I+++ + A + ++ + D
Sbjct: 522 EKCALQRQL------EDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575
Query: 681 CPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSII 740
+ + E + + +++ + KL + + + + + ++ E L R ++
Sbjct: 576 VSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERL-----RTQLL 630
Query: 741 DLKEKEIPELRNKLQNVNR-DIQRLKNDI----EEQETLLGTIMPEEESAKVCLTDVTIM 795
E+E+ +L+ L+ +R +I++LK+++ ++Q L M ++ D I
Sbjct: 631 FSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLIT 690
Query: 796 ERFQM-----ELKDVERKIAQQAAK---LQGIDLDRTVQQVNQEKQEK---QHKLDTVSS 844
++ Q+ +LKD+++ + ++ LQ +L + ++ + QE++EK + ++ +
Sbjct: 691 KQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQL 750
Query: 845 KIELNRKLIQ----DQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQS 900
K EL K ++ D QE+ L++ + LK EK + L+ +S E +
Sbjct: 751 KTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIH-------TPVSQEERL 803
Query: 901 LYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIH-GYMK 959
++ + +K + S E +E +E E+L + N+ + + N KN Y +
Sbjct: 804 IFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQE 863
Query: 960 DIENY-----IQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDI------ 1008
E Y ++D +D K ++E E + L+E E H ++IN M+ +
Sbjct: 864 LQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNE-ELHLQRINPTTVKMKSSVFDEDKT 922
Query: 1009 ---DTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENID 1065
+T ++ E +D L ++ E K + E Q L ++ + Q+ Q E L E +
Sbjct: 923 FVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSE-QLKQKHGEISFLNEEVK 981
Query: 1066 NIKRNHNLALGRQKGYEEEIIHFKKE 1091
++K+ R + E I H + E
Sbjct: 982 SLKQEKEQVSLRCRELEIIINHNRAE 1007
Score = 127 bits (320), Expect = 5e-29
Identities = 199/959 (20%), Positives = 420/959 (43%), Gaps = 139/959 (14%)
Query: 166 LSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRD 225
+++ + +++ F + AT +K E LR+ + + ++ +EL + + D
Sbjct: 1873 VTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYA---D 1929
Query: 226 QITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKD 285
+ T E Q+ +I+ E EL NRL+E+E ++ ++ E + L +K+ M+ +
Sbjct: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELE---AEQQQIQEERELLSRQKEAMKAE 1986
Query: 286 NSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRE--LEKLNKESRLLNQEK 343
+E+++ Q T++ + KE+ V C E + L K+ + L +
Sbjct: 1987 AGPVEQQL---LQETEKLM-------------KEKLEVQCQAEKVRDDLQKQVKALEIDV 2030
Query: 344 SELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRER 403
E + ++L+ +++ E + R Q+L QLE R E+ I H+ R+
Sbjct: 2031 EEQV--SRFIELEQEKNTELMDLRQQ-NQALEKQLEK---MRKFLDEQAIDREHE--RDV 2082
Query: 404 QEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYE 463
+ E + Q + + + + Q E+ L + SE+L K+ ++++
Sbjct: 2083 FQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQER 2142
Query: 464 LQQLEGSSDRILELDQEL----------IKAERELS-----KAEKNSNVETLKMEVISLQ 508
+++E R+ EL+Q L ++A+ ELS +AE+++ ++ + E+ +L+
Sbjct: 2143 NEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDA-IDRKEKEITNLE 2201
Query: 509 NEKADLDRTLRKLDQEMEQLN-------HHTTTRTQMEMLTKDKADKDEQ------IRKI 555
+ L ++E++QL+ +TTR Q E+ ++K KD+ I++
Sbjct: 2202 EQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQ-ELEQENKLFKDDMEKLGLAIKES 2260
Query: 556 KSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQN-----KNH 610
+ + + L G F + K EI+Q +++ KL ++L + N KN
Sbjct: 2261 DAMSTQDQHVLFGKF------AQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNE 2314
Query: 611 INNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFI 670
+ +L+ + E L S ++ C ++ E ++++L E IEK ++ A + T++ +
Sbjct: 2315 LIRDLETQIECLMSDQE-----CVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAH-- 2367
Query: 671 TQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEML 730
L++E S V + L++ + ++ + LK T K + E+
Sbjct: 2368 -SLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNF---KMNQLTQELF 2423
Query: 731 GLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLT 790
L R+S+ K + IPE +VN I L D E E +L E A L
Sbjct: 2424 SLKRERESV--EKIQSIPE-----NSVNVAIDHLSKDKPELEVVL------TEDALKSLE 2470
Query: 791 DVTIMERFQMELK----DVERKIAQQAAKLQGIDLDRT--VQQVNQEKQEKQHKLDTVSS 844
+ T + F+ K ++E ++ Q + + DL+ T +Q+ +++ Q + + +
Sbjct: 2471 NQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK 2530
Query: 845 KIELNRKLIQDQ-------QEQIQHLKSTTNELKSEKLQIS----TNLQRRQQLEEQTVE 893
KI +K+++++ Q Q++ ++ + + S TN+Q QL E E
Sbjct: 2531 KIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED--E 2588
Query: 894 LSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKN 953
L +++ +L I + + QV + T+L ++E+ E+ K ++ EK K
Sbjct: 2589 LGSDISALTLRISELESQVVEMHTSL-ILEKEQVEIAEK-------------NVLEKEKK 2634
Query: 954 IHGYMKDIENYIQDGKDDYKKQ--KETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQ 1011
+ K +E + ++ KK+ ++ E+ K +L + NE L + + T+
Sbjct: 2635 LLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATK 2694
Query: 1012 ------KIQERWLQDNLTLRKRN-EELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEEN 1063
K + LQ+ L +++ N L++ + + HL E + + K + +++E+
Sbjct: 2695 AELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQES 2753
Score = 119 bits (297), Expect = 2e-26
Identities = 209/1048 (19%), Positives = 452/1048 (43%), Gaps = 153/1048 (14%)
Query: 229 SKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSE 288
++E L S + + E L+ + ++EH +K+ + E+ R+KQ ++ +
Sbjct: 1839 NEELMLNISSRLQAAVEKLLEAISETSSQLEH--AKVTQ--TELMRESFRQKQEATESLK 1894
Query: 289 LEEKMEKVFQGTDEQLNDLYHNHQRTVRE--KERKLVDCHRELEKL-----NKESRLLNQ 341
+E++ E+L++ ++ E K ++D + + + L +++ ++++
Sbjct: 1895 CQEELR-------ERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDR 1947
Query: 342 EKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVR 401
+ ELL RLQ + + Q+ I+ L L+ Q E E GP ++ ++ KL++
Sbjct: 1948 LEQELLCASNRLQ-ELEAEQQQIQEEREL---LSRQKEAMKAEAGPVEQQLLQETEKLMK 2003
Query: 402 ERQEGEAKTANQLMNDFAEKETLKQKQIDEIR-DKKTGLGRIIELKSEILSKKQNELKNV 460
E+ E + + A ++ +D QKQ+ + D + + R IEL+ E K EL ++
Sbjct: 2004 EKLEVQCQ-AEKVRDDL-------QKQVKALEIDVEEQVSRFIELEQE----KNTELMDL 2051
Query: 461 KYELQQLEGSSDRILE-LDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLR 519
+ + Q LE +++ + LD++ I E E ++ ++ L+ ++ + + + R
Sbjct: 2052 RQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQE--IQKLEQQLKVVPRFQPISEHQTR 2109
Query: 520 KLDQEMEQLNHHTTTRTQM----EMLTKDKADKDEQIRKIKSRHSDELTSLL-------G 568
+++Q L T +++ E L +D +++E+I K++ R + +LL G
Sbjct: 2110 EVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFG 2169
Query: 569 YFPNKKQLE---------DWLHSKSKEINQTRDRLAKLNKELASS--EQNKNHINNELKR 617
K +L D + K KEI ++L + +EL + E + H+ E+++
Sbjct: 2170 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2229
Query: 618 KEE----QLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQL 673
KE Q E+KLF D E +KE S++ + +L G ++Q I +
Sbjct: 2230 KESTTRLQELEQENKLF----KDDMEKLGLAIKESDAMSTQDQHVLFGK---FAQIIQEK 2282
Query: 674 TDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPD-KLKSTESELKKKEKRRDEMLGL 732
E +L E ++ LQ +L++ D K+ ++EL + + + E L
Sbjct: 2283 EVEID--------------QLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECL-- 2326
Query: 733 VPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDV 792
+ ++ + +E+EI +L ++ + +++ +I ++ ++ + EE + DV
Sbjct: 2327 MSDQECVKRNREEEIEQLNEVIEKLQQELA----NIGQKTSMNAHSLSEEADSLKHQLDV 2382
Query: 793 TIMERF----QMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQ--HKLDTV---- 842
I E+ Q+E + E + K +++ Q++ K+E++ K+ ++
Sbjct: 2383 VIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENS 2442
Query: 843 ---------SSKIELNRKLIQDQQEQIQ---HLKSTTNELKSEKLQISTNLQRRQQLEEQ 890
K EL L +D + ++ + KS K + + T L QLE
Sbjct: 2443 VNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLL---QLEST 2499
Query: 891 TVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEK 950
E+ Y++IKD +EQ L+K ++++ +K + ++Q +L ++E
Sbjct: 2500 VSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEY 2559
Query: 951 VKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDT 1010
K + QD + + + T + + QL E +++ D+ + I
Sbjct: 2560 AK-----------FCQDNQTISSEPERTNIQN-LNQLRE-----DELGSDISALTLRISE 2602
Query: 1011 QKIQERWLQDNLTLRKRNEELKE---VEEERK----QHLKEMGQMQVLQMKSEHQKLEEN 1063
+ Q + +L L K E+ E +E+E+K Q L E + + Q + E ++ ++
Sbjct: 2603 LESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKK--QREKEKKRSPQD 2660
Query: 1064 IDNIKRNHNL-ALGRQKGYEEEIIHFKKE-----LREPQFRDAEEKYREMMIVMRTT-EL 1116
++ +K L + G+ E+ + E +++ EK +E ++V T
Sbjct: 2661 VEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTS 2720
Query: 1117 VNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIE-IRSDADENVSA 1175
+ KDL L +A K ++ E+ ++ + I+ + I S D +
Sbjct: 2721 LQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKI 2780
Query: 1176 SDKRRNYNYRVVMLKGDTALDMRGRCSA 1203
S N ++++ ++++ CS+
Sbjct: 2781 SSS--NQTPQILVKNAGIQINLQSECSS 2806
Score = 102 bits (253), Expect = 3e-21
Identities = 189/978 (19%), Positives = 406/978 (41%), Gaps = 114/978 (11%)
Query: 211 KYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDN 270
K L + +E+ + +I + + +LT+SK+ + E+ L ++E++ K + +
Sbjct: 357 KLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFET 416
Query: 271 EIKALDSRKKQMEKDNSELEEKMEKVF-QGTDEQLNDLYHNHQRTVRE-KERKLVDCHRE 328
+I + +++ ++ +L ++++++ Q + +L H + E K R +
Sbjct: 417 DI--VQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENA 474
Query: 329 LEKLNK------ESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDG 382
L + + +L+N +EL ++ Q ++ +E + +L QLE D
Sbjct: 475 LRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLE-DL 533
Query: 383 FERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRI 442
E FS QI+ + + E QE + A+ K + + D K +
Sbjct: 534 VEELSFSREQIQRARQTIAE-QESKLNEAH--------------KSLSTVEDLKAEIVSA 578
Query: 443 IELKSEILSKKQNELKNVKYELQQLEGSSDRIL---------ELD----QELIKAERELS 489
E + E+ K + E+ N K +L+ LE + +L EL+ Q L E ELS
Sbjct: 579 SESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELS 638
Query: 490 KAEKNSNVETLKMEVISLQNE-----KADLDRTLRKLDQEME--QLNHHTTTRTQMEMLT 542
K +++ +E ++ + L++ K +D ++ Q++E Q Q +++
Sbjct: 639 KLKEDLEIEH-RINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLIL 697
Query: 543 KDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLE-DWLHSKSKEINQTRDRLAKLNKEL 601
+ KD Q + S+ S+E+T + N+ Q E + L + KE + +L +
Sbjct: 698 EISKLKDLQQSLVNSK-SEEMTLQI----NELQKEIEILRQEEKEKGTLEQEVQELQLKT 752
Query: 602 ASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAG 661
E+ N+L+ K QL + L D + ++ D LK S ++R +
Sbjct: 753 ELLEKQMKEKENDLQEKFAQLEAENSILKD-----EKKTLEDMLKIHTPVSQEERLIFLD 807
Query: 662 A------TAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKST 715
+ +V+ + I L +EN+ C +L E I ++ A +
Sbjct: 808 SIKSKSKDSVWEKEIEILIEENEDLKQQC-------IQLNEEIEKQRNTFSFAEKNFEVN 860
Query: 716 ESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQ---------RLKN 766
EL ++E L+ ++ + D K K+ E ++KL+ +N ++ ++K+
Sbjct: 861 YQEL------QEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKS 914
Query: 767 DIEEQ------ETL-LGTIMPEEESAKVCLTDVTIMERFQM--ELKDVERKIAQQAAKLQ 817
+ ++ ETL +G ++ ++ + + +VT E+ ++ L D+ ++ Q+ ++
Sbjct: 915 SVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEIS 974
Query: 818 GIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNR-KLIQDQQEQIQHLKSTTNELKSEKLQ 876
L+ V+ + QEK++ + + I NR + +Q Q+ L + S +
Sbjct: 975 --FLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAE 1032
Query: 877 ISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTS 936
S + + EE + + +V + + +Q + L +E + + +
Sbjct: 1033 GSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSEN 1092
Query: 937 NKIAQDKLNDIKEKVKNIHGYMKD----IENYIQDGKDDYKKQKETELNKVIAQLSE--C 990
+K+ Q +LN +K + ++ M+ + D ++ E E +K + L E
Sbjct: 1093 DKL-QKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELI 1151
Query: 991 EKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKE----MG 1046
+EKI E ++ + ++ T K QE + + K V EE L+ +G
Sbjct: 1152 FAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLG 1211
Query: 1047 QMQVLQMKSE--HQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKY 1104
+ +K E + E + D I N + L + Y E+ F++ + + EE
Sbjct: 1212 EYYTPALKCEVNAEDKENSGDYISENEDPEL---QDYRYEVQDFQENMHTLLNKVTEEYN 1268
Query: 1105 REMMIVMRTTELVNKDLD 1122
+ +++ R +++ + D
Sbjct: 1269 KLLVLQTRLSKIWGQQTD 1286
Score = 79.7 bits (195), Expect = 2e-14
Identities = 206/998 (20%), Positives = 428/998 (42%), Gaps = 157/998 (15%)
Query: 187 KALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYEN 246
K + L+++ + + Q++L+ +++Y K C+ +Q S E + T+ + + + E+
Sbjct: 2530 KKIVNLQKIVEEKVAAALVSQIQLEAVQEYA-KFCQ-DNQTISSEPERTNIQNLNQLRED 2587
Query: 247 EL----DPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDE 302
EL L R+ E+E S+++++ +L K+Q+E + EK +K+ +
Sbjct: 2588 ELGSDISALTLRISELE---SQVVEMHT---SLILEKEQVEIAEKNVLEKEKKLLE---- 2637
Query: 303 QLNDLYHNHQRTVREKERK-------LVDCHRELEKLNKESRLLNQ------EKSELLVE 349
L L +++ REKE+K ++ EL N+ES N+ E E
Sbjct: 2638 -LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAE 2696
Query: 350 QGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAK 409
+ +A++ QE + +++ + SL L R +E + K ++ + E E +
Sbjct: 2697 LASYKEKAEKLQEELLVKETNMTSLQKDLSQ---VRDHLAEAKEKL--SILEKEDETEVQ 2751
Query: 410 TANQ----------LMNDFAEKE--TLK---QKQIDEIRDKKTGLGRIIELKSEILSKKQ 454
+ + L A + TLK Q +I K G+ I L+SE S++
Sbjct: 2752 ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ--INLQSECSSEEV 2809
Query: 455 NELKNVKYE----LQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNE 510
E+ + E +Q+L + IL+++ I +E E K E V+ LK E +L
Sbjct: 2810 TEIISQFTEKIEKMQELHAAE--ILDMESRHI-SETETLKREHYVAVQLLKEECGTL--- 2863
Query: 511 KADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSD--------E 562
KA + K + +L H +T+ + +D + I S+ D E
Sbjct: 2864 KAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEE 2923
Query: 563 LTSLLGYFPNK-KQLEDWLHSKSKEINQTRDRLAKLNKELASS-------EQNKNHINNE 614
S FP K K L +H++ ++ + ++ + E+ K +IN
Sbjct: 2924 SESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTI 2983
Query: 615 LKRKE---EQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFIT 671
K+ + E +++D SQ ES D E + + Q+ L + + + F T
Sbjct: 2984 SSLKDLITKMQLQREAEVYD--SSQSHESFSDWRGELL--LALQQVFLEERSVLLAAFRT 3039
Query: 672 QLT-----DENQSCCPVCQRVFQTEAELQEVISDLQ--------SKLRLAPDKLKSTESE 718
+LT D + QR+ + E Q + LQ S+++ ++ +
Sbjct: 3040 ELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKIT 3099
Query: 719 LKKK---EKRRDEMLGL-VPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETL 774
LK++ EK E+L + +QS + + E+ ++++ + + K + E ++
Sbjct: 3100 LKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSE 3159
Query: 775 LG-TIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQ 833
L T + E + K + +E F++E+KD ++ L+ T+ ++ +
Sbjct: 3160 LAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHL---------LNDTLASEQKKSR 3210
Query: 834 EKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVE 893
E Q L+ K +L R +D++E ++ LK + K LQ++ L++++QL ++ +
Sbjct: 3211 ELQWALE--KEKAKLGRSEERDKEE-LEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQ 3267
Query: 894 LSTEVQSLY-REIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVK 952
+ LY ++ + + + L+ LE S K+ +++ ++ +
Sbjct: 3268 KIESQRMLYDAQLSEEQGRNLELQVLLE---------------SEKVRIREMSSTLDRER 3312
Query: 953 NIHGYMKDIENYIQ--------DGKDDYKKQKETELNKVIAQLSECEKHK-------EKI 997
+H ++ + Q D + +KQ E + ++++ L+E EK+K +++
Sbjct: 3313 ELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQM 3372
Query: 998 NEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEH 1057
+D ++ R+ + T++ + N +K+ EL+ E+ ++ L+E Q QV ++ E
Sbjct: 3373 EKDRQVHRKTLQTEQ------EANTEGQKKMHELQSKVEDLQRQLEEKRQ-QVYKLDLEG 3425
Query: 1058 QKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREP 1095
Q+L+ + ++ L R++ E I + + L EP
Sbjct: 3426 QRLQGIMQEFQKQE---LEREEKRESRRILY-QNLNEP 3459
Score = 76.3 bits (186), Expect = 2e-13
Identities = 178/958 (18%), Positives = 383/958 (39%), Gaps = 125/958 (13%)
Query: 195 VRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNR 254
V QT+ K+ Q + L+ +E + + S +Q+T+ ++I +++++L L++
Sbjct: 1272 VLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDL 1331
Query: 255 LKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHN---- 310
K KL+ +++ L+S +++ E E+ E ++L + +
Sbjct: 1332 EKT---------KLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPP 1382
Query: 311 ----HQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRA 366
+ E + + K N + + + + E ++L ++QE +
Sbjct: 1383 SLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEE 1442
Query: 367 RD-----SLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQE--GEAKTANQLMNDFA 419
S+ + A Q EL G + K H + ++ Q E K + + F
Sbjct: 1443 EVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIG-FQ 1501
Query: 420 EKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQ 479
ET+ K +E + LG E EIL + + S D +L + +
Sbjct: 1502 TFETVDVKFKEEFKPLSKELG---EHGKEILLSNSDP--------HDIPESKDCVLTISE 1550
Query: 480 ELIKAER----------ELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLN 529
E+ ++ E+S + +++ + + E L++ + +L R ++ Q E L
Sbjct: 1551 EMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEE-QLEDMRQELVRQYQEHQQATELLR 1609
Query: 530 HHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQ 589
QME +D+ E+I+++ +QL ++ +
Sbjct: 1610 Q--AHMRQMERQREDQEQLQEEIKRLN-----------------RQLAQRSSIDNENLVS 1650
Query: 590 TRDRLAKLNKELASSEQ----NKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRL 645
R+R+ L +EL + +Q + + EL+ Q + + +V E +LDR
Sbjct: 1651 ERERV--LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708
Query: 646 KEEI--EKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVIS---- 699
E++ E S +R L A N + V +T A ++E I
Sbjct: 1709 PEDVPPEILSNERYALQKA--------------NNRLLKILLEVVKTTAAVEETIGRHVL 1754
Query: 700 ---DLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELR-NKLQ 755
D SK + + + +E+E K +E + +SI ++P N
Sbjct: 1755 GILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTD--ESIPSYSGSDMPRNDINMWS 1812
Query: 756 NVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAK 815
V + L + I PE E + I R Q ++ + I++ +++
Sbjct: 1813 KVTEEGTELSQRLVRSGFAGTEIDPENEELML-----NISSRLQAAVEKLLEAISETSSQ 1867
Query: 816 LQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKL 875
L+ + +T + + + ++KQ +++ + EL +L ++ + + Q EL +
Sbjct: 1868 LEHAKVTQT-ELMRESFRQKQEATESLKCQEELRERLHEESRAREQ----LAVELSKAEG 1922
Query: 876 QISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNT 935
I + E Q E + + L +E+ A ++ LE ++ Q+E+E L +K
Sbjct: 1923 VIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEA 1982
Query: 936 SNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQ---KETELNKVIAQLSECEK 992
A + ++ + + +++ + +DD +KQ E ++ + +++ E E+
Sbjct: 1983 MKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ 2042
Query: 993 HKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVL- 1051
K D+R Q ++ Q + R D + + +E ++V ++ Q L++ Q++V+
Sbjct: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHE--RDVFQQEIQKLEQ--QLKVVP 2098
Query: 1052 --QMKSEHQ--KLEENIDNIKRN----HNLALGRQKGYEEEIIHFKKELREPQFRDAE 1101
Q SEHQ ++E+ +++K L L +++ + +I +E+ + +FR E
Sbjct: 2099 RFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQ-LQRDIQERNEEIEKLEFRVRE 2155
Score = 68.9 bits (167), Expect = 3e-11
Identities = 200/996 (20%), Positives = 408/996 (40%), Gaps = 154/996 (15%)
Query: 202 KVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHN 261
++ E Q E++ L+Q +++ + ++ +E QL + + L+ ++KE E++
Sbjct: 720 QINELQKEIEILRQEEKEKGTLEQEV--QELQL------------KTELLEKQMKEKEND 765
Query: 262 L-SKIMKLDNEIKALDSRKKQME---KDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVRE 317
L K +L+ E L KK +E K ++ + ++ +F L+ + + +V E
Sbjct: 766 LQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF------LDSIKSKSKDSVWE 819
Query: 318 KERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQ 377
KE +++ E E L ++ LN+E +E+ R + ++ L + A
Sbjct: 820 KEIEIL--IEENEDLKQQCIQLNEE-----IEKQRNTFSFAEKNFEVNYQE-LQEEYACL 871
Query: 378 LELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKT 437
L++ ++++++ KL +E + N T+K K + KT
Sbjct: 872 LKVKDDLEDSKNKQELEYKSKLKALNEELHLQRIN--------PTTVKMKS-SVFDEDKT 922
Query: 438 GLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNV 497
+ +E+ E++ K EL +++LE + LEL Q L +L +K+ +
Sbjct: 923 FVAETLEM-GEVVEKDTTEL------MEKLEVTKREKLELSQRLSDLSEQLK--QKHGEI 973
Query: 498 ETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQM----------EMLTKDKAD 547
L EV SL+ EK + R+L+ +NH+ Q ++T
Sbjct: 974 SFLNEEVKSLKQEKEQVSLRCRELE---IIINHNRAENVQSCDTQVSSLLDGVVTMTSRG 1030
Query: 548 KDEQIRKIKSRHSDELTSLLGYFPNKKQLEDW-LHSKSKEINQTRDRLAKLNKELASSEQ 606
+ + K+ +E ++ +K E+ + +SK+ D L + KE +S
Sbjct: 1031 AEGSVSKVNKSFGEESKIMV---EDKVSFENMTVGEESKQEQLILDHLPSVTKE-SSLRA 1086
Query: 607 NKNHINNELKRKEEQLSSYEDKL------FDVCGSQDFESDLDRLKEEIEKSSKQRAMLA 660
+ N++L+++ L S ++ L +C S + + +D+++E +E +
Sbjct: 1087 TQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSL 1146
Query: 661 GATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEV--ISDLQSKLRLAPDKL-KSTES 717
+++Q + Q++ Q E + + D L L KL K+
Sbjct: 1147 KEELIFAQ---------EEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSE 1197
Query: 718 ELKKKEKRRDEMLG--LVPMRQSIIDLKEKE-----IPELRN-KLQNVNRDIQRLKNDIE 769
E + +LG P + ++ ++KE I E + +LQ+ ++Q + E
Sbjct: 1198 ECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQ---E 1254
Query: 770 EQETLLGTIMPEEESAKVCLTDVTIMERFQ---MELKDVERKIAQQAAKLQGIDLDRTVQ 826
TLL + E V T ++ + Q M+L+ E + ++ + I Q
Sbjct: 1255 NMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIH----SQ 1310
Query: 827 QVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSE-----KLQISTNL 881
N E + HK +SS +L + +++Q ++++ L S+ + E + +I
Sbjct: 1311 MTNLEDIDVNHK-SKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQ 1369
Query: 882 QRRQQLEEQTVELSTEVQSLYREIKDAKEQVSP-------LETTLEKFQQE---KEELIN 931
+R Q + E TV S V S+ DA+ + P ++ T+E F E KEE N
Sbjct: 1370 KRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIE-FSGEFGVKEE-TN 1427
Query: 932 KKNTSNKIAQDKLNDIKEKV---KNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLS 988
K Q++L + KV +I + + I GK++ K+ +
Sbjct: 1428 IVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH--------A 1479
Query: 989 ECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQM 1048
C++ + NE M+L + I Q + + K EE K + +E +H KE
Sbjct: 1480 VCQQEQHYFNE-MKLSQDQIGFQTFETVDV-------KFKEEFKPLSKELGEHGKE---- 1527
Query: 1049 QVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMM 1108
+L S+ + E+ D + L + + +++ ++ + + + + R++M
Sbjct: 1528 -ILLSNSDPHDIPESKDCV-----LTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLM 1581
Query: 1109 IVMRTTELVNKDLDIYYKTLDQA---IMKFHSMKME 1141
+ E + ++L Y+ QA + + H +ME
Sbjct: 1582 LNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQME 1617
Score = 68.6 bits (166), Expect = 4e-11
Identities = 167/863 (19%), Positives = 339/863 (39%), Gaps = 127/863 (14%)
Query: 166 LSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMEL---------KYLKQY 216
L EG KQ+ E + + ++ L+T ++ + + ++E L Y
Sbjct: 2641 LLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASY 2700
Query: 217 KEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEH---------------- 260
KEKA ++++++ KE +TS ++ + + L K +L +E
Sbjct: 2701 KEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFE 2760
Query: 261 ----NLSKIM--KLDNEIKALDSRKK----------QMEKDNSELEEKMEKVFQGTDEQL 304
LSK + + D +K S + Q+ + E++ ++ E++
Sbjct: 2761 PLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKI 2820
Query: 305 NDLYHNHQRTVREKERKLVDCHRELEKLNKES----RLLNQEKSELLVEQGRLQ------ 354
+ H + + E + + E E L +E +LL +E L L+
Sbjct: 2821 EKMQELHAAEILDMESRHIS---ETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSS 2877
Query: 355 ----LQADRHQ-EHIRARDS---------LIQSLATQLELDGFERGPFSERQIKNFHKLV 400
+D +Q I + DS L S + +G RG SE +F K +
Sbjct: 2878 IPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEG--RGEESESATDSFPKKI 2935
Query: 401 RERQEGEAKTANQLM----NDFAEKETLKQKQIDE--IRDKKTGLGRIIELKSEILSKKQ 454
+ Q++ + +++ E +Q+ E + ++K + I LK ++++K Q
Sbjct: 2936 KGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLK-DLITKMQ 2994
Query: 455 NELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADL 514
+ + Y+ Q S + + EL+ A +++ E++ + + E+ +L D
Sbjct: 2995 LQREAEVYDSSQ---SHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGT--TDA 3049
Query: 515 DRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKK 574
L L+Q +++ Q M KAD+ + +I++ H+ + ++
Sbjct: 3050 VGLLNCLEQRIQEQG----VEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQE 3105
Query: 575 QLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCG 634
+ I Q + ++ ++ EL+S + + +EQLSS +K+
Sbjct: 3106 SEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL-------QEQLSS--EKMV---- 3152
Query: 635 SQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAEL 694
+ +S+L + K E+E + K + + + TDE + T A
Sbjct: 3153 VAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDE-------VHLLNDTLASE 3205
Query: 695 QEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKL 754
Q+ +LQ L +K K SE + KE+ D L +Q + L L +
Sbjct: 3206 QKKSRELQ--WALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLL----LEQQK 3259
Query: 755 QNVNRDIQRLKNDIEEQETLLGTIMPEEE----SAKVCLTDVTIMERFQMELKDVERKIA 810
Q +N Q+ IE Q L + EE+ +V L + R D ER++
Sbjct: 3260 QLLNESQQK----IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELH 3315
Query: 811 QQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKI-ELNRKLIQDQQEQIQHLKSTTNE 869
Q G R +E Q +L+ S+I EL + + + + +Q + +
Sbjct: 3316 AQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKD 3375
Query: 870 LKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQ------ 923
+ + + T + + +++ EL ++V+ L R++++ ++QV L+ ++ Q
Sbjct: 3376 RQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEF 3435
Query: 924 QEKEELINKKNTSNKIAQDKLND 946
Q++E +K S +I LN+
Sbjct: 3436 QKQELEREEKRESRRILYQNLNE 3458
Score = 65.1 bits (157), Expect = 4e-10
Identities = 140/695 (20%), Positives = 289/695 (41%), Gaps = 117/695 (16%)
Query: 440 GRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVET 499
GR I LK E S+K ++ + ++Y +QQ + ++LE+ EL + ++ ++ + E
Sbjct: 3095 GRKITLKREQESEKPSQ-ELLEYNIQQKQS---QMLEMQVELSSMKDRATELQEQLSSE- 3149
Query: 500 LKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRH 559
KM V L K++L +T +L+ ++ + H + KDK D+ +
Sbjct: 3150 -KMVVAEL---KSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLL------- 3198
Query: 560 SDELTSLLGYFPNKKQLE-DWLHSKSK-----EINQTRDRLAKLNKELASSEQNKNHINN 613
+D L S KK E W K K + ++ L L L S +Q +N
Sbjct: 3199 NDTLAS-----EQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNL 3253
Query: 614 ELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQL 673
L+++++ L+ + K+ SQ D +L EE ++ + + +L + + L
Sbjct: 3254 LLEQQKQLLNESQQKI----ESQRMLYDA-QLSEEQGRNLELQVLLESEKVRIREMSSTL 3308
Query: 674 TDENQSCCPVCQRVFQTEAELQEVISDLQSKLRL-APDKLKSTESELKKKEKRRDEMLGL 732
E + A+LQ QS+ L + D LK + +L++K R
Sbjct: 3309 DRERE-----------LHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSR------- 3350
Query: 733 VPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDV 792
I EL N+ + D + + +E+ + + E+ A
Sbjct: 3351 --------------IVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANT--EGQ 3394
Query: 793 TIMERFQMELKDVERKIAQQAAKLQGIDLD-RTVQQVNQEKQEKQHKLDTVSSKIELNRK 851
M Q +++D++R++ ++ ++ +DL+ + +Q + QE Q+++ + + K E R
Sbjct: 3395 KKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE---EKRESRRI 3451
Query: 852 LIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQ 911
L Q+ E T++ ++ LQ + ++ + +E++ E++ +++
Sbjct: 3452 LYQNLNEPTTW-SLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQK 3510
Query: 912 VSPLETTLEKFQQEKEELINKKNTSNKI---AQDKLNDIKEKVKNIHGYMKDIENYIQDG 968
+ + + L+ Q+ E + + ++ Q+ +++I +++ + G + + +
Sbjct: 3511 LQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3570
Query: 969 KD-----DYKKQKETELNKVIAQLSECEKHK-----EKINEDMRLMRQD----------- 1007
+ ++ EL I+QL+E EK+ K+ E +R RQ
Sbjct: 3571 TSCGSLTERLLRQNAELTGHISQLTE-EKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3629
Query: 1008 ----------IDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEH 1057
I ++K E W ++ LTL+K + + + K L+ +Q L SEH
Sbjct: 3630 LNGGANIEAIIASEK--EVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEH 3687
Query: 1058 QKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKEL 1092
L KR + L R + + + +I+ KK L
Sbjct: 3688 VTL-------KRIYGKYL-RAESFRKALIYQKKYL 3714
Score = 59.7 bits (143), Expect = 2e-08
Identities = 109/507 (21%), Positives = 222/507 (43%), Gaps = 68/507 (13%)
Query: 805 VERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQ-EQIQHL 863
V+ ++Q A+ D ++ + E KQH+++ ++ ++E R + +Q+Q
Sbjct: 141 VDDSYSEQGAQ----DSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEF 196
Query: 864 KSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQ 923
++ + Q++ NLQ+ ++ +++T+ RE + EQ L+ +FQ
Sbjct: 197 EAAIKQRDGIITQLTANLQQARREKDETM----------REFLELTEQSQKLQI---QFQ 243
Query: 924 QEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKV 983
Q + + +T + A D L K+++ +++ ++ ++D Y+K+KE +
Sbjct: 244 QLQASETLRNSTHSSTAADLLQ-AKQQILTHQQQLEEQDHLLED----YQKKKE-DFTMQ 297
Query: 984 IAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEEL--KEVEEERKQ- 1040
I+ L E K K+ E M QD + + +Q+ T+ EEL K +EEE+K
Sbjct: 298 ISFLQE----KIKVYE----MEQDKKVENSNKEEIQEKETII---EELNTKIIEEEKKTL 346
Query: 1041 HLKE-MGQMQVLQMKSEHQKLEEN--IDNIKRNHNLALGRQKGYEEEIIHFKKELREPQF 1097
LK+ + L + + Q +++N I N+K + +++ EEI + E Q
Sbjct: 347 ELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQK 406
Query: 1098 RDAEEKYREMMIVMRTTELVNKDLDIYYKTLD-----------QAIMKFHSMKMEEINKI 1146
R+ ++ E IV R + + L+ LD Q +++ H +MEE+
Sbjct: 407 RNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTR 466
Query: 1147 IRDLWRSTYRGQDIEYIEIRSDADE----NVSASD---KRRNYNYRVVMLKGDTALDMRG 1199
+ + R Y I + D+ NV+ ++ K ++ N + LK + L +
Sbjct: 467 HKGEMENALR----SYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEE 522
Query: 1200 RCSAGQKVLASLIIRLALA-ETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQ 1258
+C A Q+ L L+ L+ + E IA E N +++ ++ EI+ +
Sbjct: 523 KC-ALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASES 581
Query: 1259 QRNFQLLVITHDEDFVELLGRSEYVEK 1285
++ +L H+ + + E +EK
Sbjct: 582 RKELEL---KHEAEVTNYKIKLEMLEK 605
Score = 51.2 bits (121), Expect = 6e-06
Identities = 196/1039 (18%), Positives = 414/1039 (39%), Gaps = 144/1039 (13%)
Query: 176 FDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLT 235
FDE T + LE V + + +++ ++ + + ++ ++ +Q+ K +++
Sbjct: 917 FDE--DKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEIS 974
Query: 236 SSKEIVKSYENELDPLKNRLKEIE----HNLSK-IMKLDNEIKAL--------------- 275
E VKS + E + + R +E+E HN ++ + D ++ +L
Sbjct: 975 FLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGS 1034
Query: 276 --DSRKKQMEKDNSELEEKM--EKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEK 331
K E+ +E+K+ E + G + + L +H +V ++ E +K
Sbjct: 1035 VSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDK 1094
Query: 332 LNKESRLLNQEKSELLVEQGRLQLQADR---------HQEHIR-----ARDSLIQSLATQ 377
L KE +L E+++L RLQ++A R H + +R +D + SL +
Sbjct: 1095 LQKELNVLKSEQNDL-----RLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEE 1149
Query: 378 LELDGFERGPFSERQIKNFHKL----VRERQEG-EAKTANQLMNDFAEKETLKQKQIDEI 432
L E+ ++++ H+L ++ ++ G E K + L+ + + + +
Sbjct: 1150 LIFAQEEK----IKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQT 1205
Query: 433 RDKKTGLGRIIELKSEILSK-KQN-----------ELKNVKYELQQLEGSS----DRILE 476
G LK E+ ++ K+N EL++ +YE+Q + + +++ E
Sbjct: 1206 LCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTE 1265
Query: 477 LDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRT 536
+L+ + LSK + +K+E + L K + E ++ T
Sbjct: 1266 EYNKLLVLQTRLSKI-WGQQTDGMKLEF---------GEENLPKEETEFLSIHSQMTNLE 1315
Query: 537 QMEMLTKDKADKDEQIRKIK-SRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLA 595
+++ K K + + K K EL SL+ ++QL++ + EI+ + RL
Sbjct: 1316 DIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSL--QQQLKETEQNYEAEIHCLQKRLQ 1373
Query: 596 KLNKELASSEQNKNHINNELKRKEEQLSSYEDKLF--DVCGSQDFESDLDRLKEE----- 648
+++ + + + + Q + Y ++ G+ +F + +KEE
Sbjct: 1374 AVSESTVPPSLPVDSV--VITESDAQRTMYPGSCVKKNIDGTIEFSGEFG-VKEETNIVK 1430
Query: 649 -IEKSSKQRAMLAGATAVYSQFI-----TQLT-----DENQSCCPVCQRVFQTEAELQEV 697
+EK +++ A + S I T+L+ EN + V Q E Q
Sbjct: 1431 LLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQE---QHY 1487
Query: 698 ISDLQ-SKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQN 756
++++ S+ ++ ++ + + K++ K + LG + + +IPE ++ +
Sbjct: 1488 FNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLT 1547
Query: 757 VNRDI-QRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAK 815
++ ++ + K I Q + ++++ + + +E + EL + Q
Sbjct: 1548 ISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQEL------VRQYQEH 1601
Query: 816 LQGIDLDRTVQQVNQEKQ-EKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEK 874
Q +L R E+Q E Q +L + LNR+L Q ++L S + E+
Sbjct: 1602 QQATELLRQAHMRQMERQREDQEQLQEEIKR--LNRQLAQRSSIDNENLVSERERVLLEE 1659
Query: 875 LQI--STNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQE--KEELI 930
L+ +L R++L + ST+ Q+ + +EQ E L++ ++ E L
Sbjct: 1660 LEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFK-EKELDRKPEDVPPEILS 1718
Query: 931 NKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKD-DYKKQKETEL---NKVIAQ 986
N++ K L + E VK + I ++ D K Q L ++ A
Sbjct: 1719 NERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEAS 1778
Query: 987 LSEC--EKHKEKINEDM------RLMRQDIDT-QKIQERWLQDNLTLRKRNEELKEVEEE 1037
+ C E+H +E + + R DI+ K+ E + + L + E++ E
Sbjct: 1779 VKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPE 1838
Query: 1038 RKQHLKEMGQM------QVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKE 1091
++ + + ++L+ SE E+ + RQK E + ++E
Sbjct: 1839 NEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEE 1898
Query: 1092 LREPQFRDAEEKYREMMIV 1110
LRE E + RE + V
Sbjct: 1899 LRERLHE--ESRAREQLAV 1915
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 129 bits (323), Expect = 2e-29
Identities = 165/798 (20%), Positives = 351/798 (43%), Gaps = 109/798 (13%)
Query: 425 KQKQIDEIRDKKTGLGRI---IELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQ-E 480
K ++I ++R K + + L S+ L + +EL + + + S+ ++L+ + E
Sbjct: 1259 KDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAE 1318
Query: 481 LIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEM 540
++AE+E+ + + + +MEV+ ++ +A L R +++ E++ + R + E
Sbjct: 1319 RLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAA-EINGEVDDDDAGGEWRLKYER 1377
Query: 541 LTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKE 600
++ D ++++ D+L NK+QLE L + +++ L +L K+
Sbjct: 1378 AVREV---DFTKKRLQQEFEDKLEVEQ---QNKRQLERRLGDLQADSEESQRALQQLKKK 1431
Query: 601 L----ASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQR 656
A + K H+ + R E + + FD SQ E + R K + EK +++
Sbjct: 1432 CQRLTAELQDTKLHLEGQQVRNHEL--EKKQRRFDSELSQAHE-EAQREKLQREKLQREK 1488
Query: 657 AMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDL---QSKLRLAPDKLK 713
ML Q QL +++ Q+V EAELQ++ S ++ L +L+
Sbjct: 1489 DMLLAEAFSLKQ---QLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLR 1545
Query: 714 STESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQET 773
E+++K +E+ DE G + M + E E+ +R Q +++++ ++EE
Sbjct: 1546 DLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMR---QTHSKEMESRDEEVEE--- 1599
Query: 774 LLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQ 833
+ + C + ME E + ++K+ ++ +L+G L QVN+
Sbjct: 1600 ----------ARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEG-KLATLSDQVNRRDF 1648
Query: 834 EKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVE 893
E + +L ++ + L+ D Q + HLK++ K E Q+ L+ + V+
Sbjct: 1649 ESEKRL---RKDLKRTKALLADAQLMLDHLKNSAPS-KREIAQLKNQLEESEFTCAAAVK 1704
Query: 894 ----LSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKE 949
+ E++ L+ +I D + + LE L + Q+EK E+ N+ Q+ +N++ +
Sbjct: 1705 ARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEED----QEDMNELMK 1760
Query: 950 KVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDID 1009
K K Q +D ++N + AQL E K K+++ E ++ ++ ++
Sbjct: 1761 KHKAA---------VAQASRD------LAQINDLQAQLEEANKEKQELQEKLQALQSQVE 1805
Query: 1010 TQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKR 1069
E+ + D + ++ +++E+E E + QV +++S +L+EN++ +
Sbjct: 1806 ---FLEQSMVDKSLVSRQEAKIRELETRL-----EFERTQVKRLESLASRLKENMEKLTE 1857
Query: 1070 NHNLALGRQKGYEEEIIHFKKELREPQFR---------DAEEKYREMMIVMRTTELVNKD 1120
+ + + +E+ +++LR+ + +A K E+ + + + E N+
Sbjct: 1858 ERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQS 1917
Query: 1121 LDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENV--SASDK 1178
L QA +K ++ ++ I D E+ SD +E++ S D
Sbjct: 1918 L--------QADLKLAFKRIGDLQAAIED--------------EMESDENEDLINSLQDM 1955
Query: 1179 RRNYNYRVVMLKGDTALD 1196
Y R L+GD+ +D
Sbjct: 1956 VTKYQKRKNKLEGDSDVD 1973
Score = 120 bits (300), Expect = 1e-26
Identities = 183/811 (22%), Positives = 346/811 (42%), Gaps = 110/811 (13%)
Query: 255 LKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRT 314
L E++ + +I D EI+ L S+ ++ EK+ +EL +++ E ++L +R
Sbjct: 1246 LIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSEL--TDERN 1303
Query: 315 VREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQAD-RHQEHIRARDSLIQS 373
E +L+D E+L E +E EL + L+ Q + E + AR LI++
Sbjct: 1304 TGESASQLLDAETA-ERLRAE-----KEMKELQTQYDALKKQMEVMEMEVMEAR--LIRA 1355
Query: 374 LATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIR 433
E+D + G E ++K + + VRE T +L +F +K ++Q+ ++
Sbjct: 1356 AEINGEVDDDDAG--GEWRLK-YERAVREVDF----TKKRLQQEFEDKLEVEQQNKRQLE 1408
Query: 434 DKKTGLGRIIELKSEILSKKQNELKNVKYELQQ----LEGSSDRILELDQELIKAERELS 489
+ L E L + + + + + ELQ LEG R EL+++ + + ELS
Sbjct: 1409 RRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELS 1468
Query: 490 KAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKD 549
+A + + E L+ E LQ EK L L Q++E+ + TQ + +
Sbjct: 1469 QAHEEAQREKLQRE--KLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVV------SLE 1520
Query: 550 EQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKN 609
+++ I S+ S + SL KKQL D L +K K+ + D A + L EQ K
Sbjct: 1521 AELQDISSQESKDEASLAKV---KKQLRD-LEAKVKDQEEELDEQAGTIQML---EQAKL 1573
Query: 610 HINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQF 669
+ E++R + S++ ES + ++E + K+ Q
Sbjct: 1574 RLEMEMERMRQT------------HSKEMESRDEEVEEARQSCQKK----------LKQM 1611
Query: 670 ITQLTDENQSCCPVCQRVFQTEAELQEVIS-----DLQSKLRLAPDKLKSTESELKKKEK 724
QL +E + V + + E +L + D +S+ RL D LK T++ L +
Sbjct: 1612 EVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKD-LKRTKALLADAQL 1670
Query: 725 RRDEMLGLVPMRQSIIDLK----EKEIP-----ELRNKLQNVNRDIQRLKNDIEEQETLL 775
D + P ++ I LK E E + R ++ D+ +DI + +T L
Sbjct: 1671 MLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTAL 1730
Query: 776 GTIMPEEESAKVCLTDVTIMERFQMELKDVER-------KIAQQAAKLQGI-DLDRTVQQ 827
EE+ +++ I R + + +D+ +AQ + L I DL +++
Sbjct: 1731 -----EEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEE 1785
Query: 828 VNQEKQEKQHKLDTVSSKIE------LNRKLIQDQQEQIQHL-------KSTTNELKSEK 874
N+EKQE Q KL + S++E +++ L+ Q+ +I+ L ++ L+S
Sbjct: 1786 ANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLA 1845
Query: 875 LQISTNLQRRQQLEEQTVELST----EVQSLYREIKDAKEQVSPLETTLEKFQQEKEELI 930
++ N+++ + +Q + + + L R+++D KE++ L + ++K EL
Sbjct: 1846 SRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELE 1905
Query: 931 NKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSEC 990
+ Q D+K K I IE+ ++ + E +N + +++
Sbjct: 1906 MDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEME------SDENEDLINSLQDMVTKY 1959
Query: 991 EKHKEKINEDMRLMRQDIDTQKIQERWLQDN 1021
+K K K+ D + + D + WL N
Sbjct: 1960 QKRKNKLEGDSDVDSELEDRVDGVKSWLSKN 1990
Score = 82.8 bits (203), Expect = 2e-15
Identities = 134/764 (17%), Positives = 312/764 (40%), Gaps = 96/764 (12%)
Query: 160 EDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEK 219
++ N S + L + E A + +K L+T + Q + ++ ME + ++ +
Sbjct: 1300 DERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEIN 1359
Query: 220 ACEIRDQITSKEAQLT----------SSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLD 269
E+ D E +L + K + + +E++L+ + +++E L +
Sbjct: 1360 G-EVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADS 1418
Query: 270 NEI-KALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRE 328
E +AL KK+ ++ +EL++ + +Q+ + H ++ R + +L H E
Sbjct: 1419 EESQRALQQLKKKCQRLTAELQDTKLHL---EGQQVRN--HELEKKQRRFDSELSQAHEE 1473
Query: 329 LEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPF 388
++ + L +EK LL E L+ Q + I + SL +L+ +
Sbjct: 1474 AQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQ----DISSQ 1529
Query: 389 SERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSE 448
+ + K+ ++ ++ EAK +Q + T++ + ++R + + R+ + S+
Sbjct: 1530 ESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLR-LEMEMERMRQTHSK 1588
Query: 449 ILSKKQNELKNVKY----ELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEV 504
+ + E++ + +L+Q+E + E Q++++ +REL + + + +
Sbjct: 1589 EMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDF 1648
Query: 505 ISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELT 564
S + + DL RT L L+H K+ A +I ++K++ +
Sbjct: 1649 ESEKRLRKDLKRTKALLADAQLMLDH-----------LKNSAPSKREIAQLKNQLEESEF 1697
Query: 565 SLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSS 624
+ +K +E + +I+ L ++L+ ++ KN I N L+ +E
Sbjct: 1698 TCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQE---- 1753
Query: 625 YEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVC 684
D + + K + ++S+ A + A QL + N+
Sbjct: 1754 ------------DMNELMKKHKAAVAQASRDLAQINDLQA-------QLEEANKE----- 1789
Query: 685 QRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKE 744
+ ELQE + LQS++ + +++ K R+ ++ ++ +
Sbjct: 1790 ------KQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRE--------LETRLEFER 1835
Query: 745 KEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKD 804
++ L + + ++++L EE++ + E+E K R Q +L+D
Sbjct: 1836 TQVKRLESLASRLKENMEKL---TEERDQRIAAENREKEQNK----------RLQRQLRD 1882
Query: 805 VERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQ-HL 863
+ ++ + A K + R ++ + + + ++ + ++L K I D Q I+ +
Sbjct: 1883 TKEEMGELARK--EAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEM 1940
Query: 864 KSTTNELKSEKLQ-ISTNLQRRQQLEEQTVELSTEVQSLYREIK 906
+S NE LQ + T Q+R+ E ++ +E++ +K
Sbjct: 1941 ESDENEDLINSLQDMVTKYQKRKNKLEGDSDVDSELEDRVDGVK 1984
Score = 68.6 bits (166), Expect = 4e-11
Identities = 134/642 (20%), Positives = 255/642 (39%), Gaps = 139/642 (21%)
Query: 637 DFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVF---QTEAE 693
+F D L + K + ++ + + L E SCC RVF T A
Sbjct: 1120 EFRRRFDVLAPHLTKKHGRNYIVVDERRAVEELLECLDLEKSSCCMGLSRVFFRAGTLAR 1179
Query: 694 LQEVISDLQS--------------------KLRLAPDKLKSTESELKKKEKRRD------ 727
L+E + S K ++ ++ + +KK + +D
Sbjct: 1180 LEEQRDEQTSRNLTLFQAACRGYLARQHFKKRKIQDLAIRCVQKNIKKNKGVKDWPWWKL 1239
Query: 728 ----EMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPE-- 781
L V + + I K++EI +LR+KL+ ++ L+ + + E+ + + E
Sbjct: 1240 FTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELT 1299
Query: 782 -----EESAKVCLTDVTIMERF------------------QMELKDVERKIAQ--QAAKL 816
ESA L D ER QME+ ++E A+ +AA++
Sbjct: 1300 DERNTGESASQ-LLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEI 1358
Query: 817 QG------------IDLDRTVQQVNQEK----QEKQHKLDT-VSSKIELNRKL------I 853
G + +R V++V+ K QE + KL+ +K +L R+L
Sbjct: 1359 NGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADS 1418
Query: 854 QDQQEQIQHLKS----TTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAK 909
++ Q +Q LK T EL+ KL + R +LE++ +E+ + E + K
Sbjct: 1419 EESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREK 1478
Query: 910 EQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDI---KEKVKNIHGYMKDIENYIQ 966
Q EK Q+EK+ L+ + + + ++K DI +KV ++ ++DI + Q
Sbjct: 1479 LQ-------REKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISS--Q 1529
Query: 967 DGKDDYK---------------KQKETELNKVIAQLSECEKHKEKINEDMRLMRQ----- 1006
+ KD+ K +E EL++ + E+ K ++ +M MRQ
Sbjct: 1530 ESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKE 1589
Query: 1007 -DIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQM---------QVLQMKSE 1056
+ ++++E L++ +L+E E++++ L+E ++ QV + E
Sbjct: 1590 MESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFE 1649
Query: 1057 HQK-LEENIDNIK---RNHNLALGRQKG---YEEEIIHFKKELREPQF--RDAEEKYREM 1107
+K L +++ K + L L K + EI K +L E +F A + + M
Sbjct: 1650 SEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAM 1709
Query: 1108 MIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRD 1149
+ + L D+ L++ + + K E N++ D
Sbjct: 1710 EVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEED 1751
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 128 bits (322), Expect = 3e-29
Identities = 195/1007 (19%), Positives = 428/1007 (42%), Gaps = 152/1007 (15%)
Query: 215 QYKEKACEIRDQITSKE---AQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNE 271
Q + K E+ +++ +E A+LT+ K + E+E LK + ++E L+K+ K E
Sbjct: 916 QLEAKVKEMNERLEDEEEMNAELTAKK---RKLEDECSELKKDIDDLELTLAKVEK---E 969
Query: 272 IKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEK 331
A +++ K + ++ + L+E + K+ ++ L HQ+ L D E +K
Sbjct: 970 KHATENKVKNLTEEMAGLDEIIAKL----TKEKKALQEAHQQA-------LDDLQVEEDK 1018
Query: 332 LNKESR---LLNQEKSEL---LVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFER 385
+N S+ L Q+ +L L ++ ++++ +R + + L Q LE D +
Sbjct: 1019 VNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQ- 1077
Query: 386 GPFSERQIKNFHKLVRERQ---EGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRI 442
E ++K + ++ E E A QL E + ++ +E+ ++T ++
Sbjct: 1078 ---LEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKV 1134
Query: 443 IELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKM 502
+L+S++ EL+ + L++ G++ +E+++ K E E K ++ TL+
Sbjct: 1135 EKLRSDL----SRELEEISERLEEAGGATSVQIEMNK---KREAEFQKMRRDLEEATLQH 1187
Query: 503 E--VISLQNEKAD-----------LDRTLRKLDQEMEQLNHHTTTRT-QMEMLTKDKADK 548
E +L+ + AD L R +KL++E + T ME + K KA+
Sbjct: 1188 EATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANL 1247
Query: 549 DEQIRKIKSRHSDELTSLLGYFPNKKQLEDW------LHSKSKEINQTRDRLAKLNKELA 602
++ R ++ + ++ L ++ L D+ L +++ E+ + + L +L
Sbjct: 1248 EKVSRTLEDQANEYRVKL---EEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLT 1304
Query: 603 SSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDL--DRLKEEIEKSSKQRAMLA 660
+ + +LKR+ E+ ++ L S + DL ++ +EE E ++ + +L+
Sbjct: 1305 RGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLS 1364
Query: 661 GATAVYSQFIT-------QLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLK 713
A + +Q+ T Q T+E + + Q E E ++ S L +L+
Sbjct: 1365 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQ 1424
Query: 714 STESELKKKEKRRDEMLGLVPMRQSIIDL-----------KEKEIPELRNKLQNVNRDIQ 762
+ +L +R + + +Q D + E+ + + ++++ ++
Sbjct: 1425 NEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELF 1484
Query: 763 RLKNDIEEQETLLGTIMPEEESAKVCLTDVTIM----ERFQMELKDVERKIAQQAAKLQG 818
+LKN EE L T E ++ + ++D+T + EL+ V +++ + +LQ
Sbjct: 1485 KLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQS 1544
Query: 819 IDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQIS 878
+ ++E + + +L+ K E+ RKL + +E Q ++ + S + +
Sbjct: 1545 ALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLD 1604
Query: 879 TNLQRRQQ-----------LEEQTVELS----------TEVQSLYREIKDA--------- 908
+ R + L E ++LS +V+SL +KD
Sbjct: 1605 AETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVR 1664
Query: 909 -----KEQVSPLETTLEKFQQEKEEL---INKKNTSNKIAQDKLNDIKEKVKNIHGYMKD 960
KE ++ +E Q E EEL + + S K+A+ +L + E+V+ +H
Sbjct: 1665 ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTS 1724
Query: 961 IENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQD 1020
+ N + + D Q ++E+ + + + E+ +K D +M +++ ++
Sbjct: 1725 LINQKKKMESDL-TQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQ------DT 1777
Query: 1021 NLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNI--------KRNHN 1072
+ L + + +++ ++ + L E Q+ + K + QKLE + + KRN
Sbjct: 1778 SAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAE 1837
Query: 1073 LALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNK 1119
G +K ++ ++E ++ E+K ++R +LV+K
Sbjct: 1838 SVKGMRKS--------ERRIKELTYQTEEDKKN----LLRLQDLVDK 1872
Score = 121 bits (304), Expect = 4e-27
Identities = 193/1051 (18%), Positives = 435/1051 (41%), Gaps = 200/1051 (19%)
Query: 204 KEYQMELKYLKQYKEKAC-EIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNL 262
+E EL K+ E C E++ I E L ++ + EN++ L + ++ +
Sbjct: 932 EEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII 991
Query: 263 SKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGT---DEQLNDLYHNHQRTVREKE 319
+K+ K E KAL +Q D E+K+ + + ++Q++DL + ++ +++
Sbjct: 992 AKLTK---EKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDL----EGSLEQEK 1044
Query: 320 RKLVDCHRELEKLNKESRLLNQ-----EKSELLVEQGRLQLQADRHQEHIRARDSLIQSL 374
+ +D R KL + +L + E +L +E+ + + D +Q++ + D + +L
Sbjct: 1045 KVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLAL 1104
Query: 375 ATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRD 434
Q +L ++ +I+ + + + AK +L +D + ++++EI +
Sbjct: 1105 QLQKKLKE------NQARIEELEEELEAERTARAKV-EKLRSDLS-------RELEEISE 1150
Query: 435 KKTGLGRIIELKSEILSKKQNELKNVKYELQQL------------EGSSDRILELDQELI 482
+ G ++ E+ K++ E + ++ +L++ + +D + EL +++
Sbjct: 1151 RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQID 1210
Query: 483 KAERELSKAEKNSNVETLKMEVISLQNE-----KADLDRTLR-----------KLDQEME 526
+R K EK + L+++ ++ E KA+L++ R KL++
Sbjct: 1211 NLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQR 1270
Query: 527 QLNHHTTTRTQMEM----LTKDKADKD---EQIRKIKSRHSDELTSLLGYFPNKKQLEDW 579
LN TT R +++ L + +K+ Q+ + K ++ ++ L K+QLE+
Sbjct: 1271 SLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDL------KRQLEEE 1324
Query: 580 LHSKSK---EINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQ 636
+K+ + R L ++ + K + L + +++ + K
Sbjct: 1325 GKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTK-------- 1376
Query: 637 DFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQE 696
+E+D + EE+E++ K+ A Q + + ++ C + +T+ LQ
Sbjct: 1377 -YETDAIQRTEELEEAKKKLA----------QRLQDAEEAVEAVNAKCSSLEKTKHRLQN 1425
Query: 697 VISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQN 756
I DL + ++ + + L KK++ D++L + + + E+ + + ++
Sbjct: 1426 EIEDLMVDV----ERSNAAAAALDKKQRNFDKILAEWKQKY---EESQSELESSQKEARS 1478
Query: 757 VNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIM----ERFQMELKDVERKIAQQ 812
++ ++ +LKN EE L T E ++ + ++D+T + EL+ V +++ +
Sbjct: 1479 LSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVE 1538
Query: 813 AAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKS 872
+LQ + ++E + + +L+ K E+ RKL + +E Q ++ + S
Sbjct: 1539 KLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDS 1598
Query: 873 EKLQISTNLQRRQQ-----------LEEQTVELS----------TEVQSLYREIKDA--- 908
+ + + R + L E ++LS +V+SL +KD
Sbjct: 1599 LQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 1658
Query: 909 -----------KEQVSPLETTLEKFQQEKEEL---INKKNTSNKIAQDKLNDIKEKVKNI 954
KE ++ +E Q E EEL + + S K+A+ +L + E+V+ +
Sbjct: 1659 LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLL 1718
Query: 955 HGY------------------MKDIENYIQDGKDDYKKQKET---------ELNKVIAQL 987
H ++E +Q+ ++ +K K+ EL K
Sbjct: 1719 HSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTS 1778
Query: 988 SECEKHKEKINEDMRLMRQDIDT-------------QKI--------------QERWLQD 1020
+ E+ K+ + + ++ ++ +D QK+ Q+R +
Sbjct: 1779 AHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAES 1838
Query: 1021 NLTLRKRNEELKEV----EEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALG 1076
+RK +KE+ EE++K L+ + LQ+K + K + + N NL+
Sbjct: 1839 VKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKF 1898
Query: 1077 RQKGYEEEIIHFKKELREPQFRDAEEKYREM 1107
R+ +E + + ++ E Q K R++
Sbjct: 1899 RKVQHELDEAEERADIAESQVNKLRAKSRDI 1929
Score = 119 bits (297), Expect = 2e-26
Identities = 186/880 (21%), Positives = 372/880 (42%), Gaps = 143/880 (16%)
Query: 329 LEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIR-ARDSLIQSLATQLELDGFERGP 387
LEK + L ++ LL E+ LQLQ Q+++ A + Q + +++L
Sbjct: 865 LEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQL------- 917
Query: 388 FSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKS 447
E ++K ++ + + +E MN AE K+K DE + K + + +
Sbjct: 918 --EAKVKEMNERLEDEEE---------MN--AELTAKKRKLEDECSELKKDIDDLELTLA 964
Query: 448 EILSKK---QNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEV 504
++ +K +N++KN+ E+ L+ E+ +L K ++ L +A + + ++ L++E
Sbjct: 965 KVEKEKHATENKVKNLTEEMAGLD-------EIIAKLTKEKKALQEAHQQA-LDDLQVE- 1015
Query: 505 ISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELT 564
+++ L ++ KL+Q+++ L +E K + D + RK++
Sbjct: 1016 ---EDKVNSLSKSKVKLEQQVDDL------EGSLEQEKKVRMDLERAKRKLEGDLKLTQE 1066
Query: 565 SLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSS 624
S++ +K QLE+ L K +INQ +K+ E + Q + + R EE
Sbjct: 1067 SIMDLENDKLQLEEKLKKKEFDINQQN---SKIEDEQVLALQLQKKLKENQARIEELEEE 1123
Query: 625 YEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVC 684
E + + SDL R E+E+ S++ GAT+V +
Sbjct: 1124 LEAERTARAKVEKLRSDLSR---ELEEISERLEEAGGATSVQIEMNK------------- 1167
Query: 685 QRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLG-LVPMRQSIIDLK 743
+ EAE Q++ DL+ A + ++T + L+KK LG + Q +
Sbjct: 1168 ----KREAEFQKMRRDLEE----ATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKL 1219
Query: 744 EKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEE-------ESAKVCLTDVTIME 796
EKE E + +L +V +++++ E + T+ + E A+ L D T
Sbjct: 1220 EKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQR 1279
Query: 797 -RFQMELKDVERKIAQQAAKLQGI------------DLDRTVQQVNQEKQEKQHKLDTVS 843
+ Q E ++ R++ ++ A + + DL R +++ + K H L +
Sbjct: 1280 AKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSAR 1339
Query: 844 SKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTN-----LQRRQQLEEQTVELSTEV 898
+L R+ +++ E L+ ++ SE Q T +QR ++LEE +L+ +
Sbjct: 1340 HDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1399
Query: 899 QSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYM 958
Q ++ + S LE T + Q E E+L+ SN A + +K +N +
Sbjct: 1400 QDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAA----ALDKKQRNFDKIL 1455
Query: 959 KDIENYIQDGKDDYK-KQKE-----TELNKVIAQLSECEKHKEKINEDMRLMRQDI---- 1008
+ + ++ + + + QKE TEL K+ E +H E + + ++++I
Sbjct: 1456 AEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLT 1515
Query: 1009 -----------DTQKIQERWLQDNLTLRKRNEELK-EVEEERKQHLKEMGQMQVLQMKSE 1056
+ +K++++ + L L+ EE + +E E + L+ Q++ Q+K+E
Sbjct: 1516 EQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILR--AQLEFNQIKAE 1573
Query: 1057 HQK----LEENIDNIKRNH-------NLALGRQKGYEEEIIHFKKELR------EPQFRD 1099
++ +E ++ KRNH +L + E++ KK++ E Q
Sbjct: 1574 IERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSH 1633
Query: 1100 AEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMK 1139
A E +++ + + KD I LD A+ +K
Sbjct: 1634 ANRMAAEAQKQVKSLQSLLKDTQI---QLDDAVRANDDLK 1670
Score = 112 bits (279), Expect = 3e-24
Identities = 206/1042 (19%), Positives = 436/1042 (41%), Gaps = 114/1042 (10%)
Query: 88 DVNGELIAVQRSMVCTQKSKKTEFKTLE---GVITRTKHGEK---VSLSSKCAEIDREMI 141
++N EL A +R + K + LE + + KH + +L+ + A +D E+I
Sbjct: 933 EMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD-EII 991
Query: 142 SSLGVSKAVLNNVIFCHQ---------EDSNWPLSEGKA-LKQKFDEIFSATRYIKA--L 189
+ L K L HQ ED LS+ K L+Q+ D++ + K +
Sbjct: 992 AKLTKEKKALQEA---HQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRM 1048
Query: 190 ETLRQVRQTQG--QKVKEYQMELKYLK-QYKEKACEIRDQITSKEAQLTSSKEIVKSYEN 246
+ R R+ +G + +E M+L+ K Q +EK + I + +++ + + +
Sbjct: 1049 DLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQK 1108
Query: 247 ELDPLKNRLKEIEHNL-------SKIMKLDNEI-KALDSRKKQMEKDNS------ELEEK 292
+L + R++E+E L +K+ KL +++ + L+ +++E+ E+ +K
Sbjct: 1109 KLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKK 1168
Query: 293 MEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHREL----EKLNKESRLLNQEKSELLV 348
E FQ L + H+ T +K D EL + L + + L +EKSE +
Sbjct: 1169 REAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKL 1228
Query: 349 EQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEA 408
E L ++ I+A+ +L + ++ LE E E ++ + +R + +
Sbjct: 1229 E---LDDVTSNMEQIIKAKANL-EKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQT 1284
Query: 409 KTANQLMNDFAEKETL-------KQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVK 461
+ +L EKE L K ++ D K L + K+ + Q+ +
Sbjct: 1285 ENG-ELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCD 1343
Query: 462 YELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKL 521
+Q E ++ EL + L KA E+++ + ++ L+ K L + L+
Sbjct: 1344 LLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQ-RTEELEEAKKKLAQRLQDA 1402
Query: 522 DQEMEQLN------HHTTTRTQME----MLTKDKADKDEQIRKIKSRHSDELTSLLGYFP 571
++ +E +N T R Q E M+ ++++ K R+ D++ L +
Sbjct: 1403 EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKI--LAEWKQ 1460
Query: 572 NKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFD 631
++ + L S KE L KL S ++ E K +E++S ++L +
Sbjct: 1461 KYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGE 1520
Query: 632 VCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTE 691
G E + R + E+EK Q A+ + L E Q +
Sbjct: 1521 G-GKNVHELEKVRKQLEVEKLELQSAL--------EEAEASLEHEEGKILRAQLEFNQIK 1571
Query: 692 AELQEVISDLQSKLRLAPDK----LKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEI 747
AE++ +++ ++ A + S ++ L + + R+E+L + + DL E EI
Sbjct: 1572 AEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEG--DLNEMEI 1629
Query: 748 PELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVER 807
+L + NR + ++ ++LL + + A V + + + VER
Sbjct: 1630 -----QLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDA------VRANDDLKENIAIVER 1678
Query: 808 KIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTT 867
+ A+L+ +L V+Q + ++ + +L S +++L Q + ++S
Sbjct: 1679 RNNLLQAELE--ELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDL 1736
Query: 868 NELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKE 927
+L+SE + +Q + EE+ + T+ + E+K ++ + LE + +Q +
Sbjct: 1737 TQLQSE---VEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIK 1793
Query: 928 ELINKKNTSNKIA----QDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKV 983
+L ++ + + +IA + +L ++ +V+ + G ++ + + +K E + ++
Sbjct: 1794 DLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRK-SERRIKEL 1852
Query: 984 IAQLSECEKHKEKINEDMRLMRQDIDTQKIQ----ERWLQDNLT-LRKRNEELKEVEEER 1038
Q E +K+ ++ + + ++ + K Q E NL+ RK EL E EE
Sbjct: 1853 TYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEER- 1911
Query: 1039 KQHLKEMGQMQVLQMKSEHQKL 1060
++ + QV +++++ + +
Sbjct: 1912 ----ADIAESQVNKLRAKSRDI 1929
Score = 97.1 bits (240), Expect = 1e-19
Identities = 158/792 (19%), Positives = 317/792 (40%), Gaps = 105/792 (13%)
Query: 477 LDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRT 536
+ +E + + L K+E + L+ +++SL EK DL ++ E + LN
Sbjct: 854 MKEEFGRIKETLEKSEARR--KELEEKMVSLLQEKNDLQL---QVQAEQDNLND---AEE 905
Query: 537 QMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAK 596
+ + L K+K + +++++ R DE K++LED K+I+ LAK
Sbjct: 906 RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAK 965
Query: 597 LNKELASSEQNKNHINNELKRKEEQLS--SYEDKLFDVCGSQDFESDLDRLKEEIEKSSK 654
+ KE ++E ++ E+ +E ++ + E K Q + DL ++++ SK
Sbjct: 966 VEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD-DLQVEEDKVNSLSK 1024
Query: 655 QRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAEL---QEVISDLQSKLRLAPDK 711
+ L L E + + + + E +L QE I DL++ +K
Sbjct: 1025 SKVKLEQQV---DDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEK 1081
Query: 712 LKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQ---NVNRDIQRLKNDI 768
LK E ++ ++ + ++ L Q + + I EL +L+ +++L++D+
Sbjct: 1082 LKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDL 1141
Query: 769 EEQETLLGTIMPEEESAKVCLTDVTIME--RFQMELKDVE--------------RKIAQQ 812
+ + + E A ++ FQ +D+E +K A
Sbjct: 1142 SRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADS 1201
Query: 813 AAKL--QGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNE- 869
A+L Q +L R Q++ +EK E + +LD V+S +E K + ++ + L+ NE
Sbjct: 1202 VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEY 1261
Query: 870 -LKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEE 928
+K E+ Q S N Q +L TE L R++++ + +S L + Q+ E+
Sbjct: 1262 RVKLEEAQRSLN-----DFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMED 1316
Query: 929 LINKKNTSNK-----------------IAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDD 971
L + K + +++ + E + + + + +
Sbjct: 1317 LKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTK 1376
Query: 972 YK-------KQKETELNKVIAQLSECEKHKEKINEDM--------RLMRQDIDTQKIQER 1016
Y+ ++ E K+ +L + E+ E +N RL + D ER
Sbjct: 1377 YETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVER 1436
Query: 1017 WLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALG 1076
L K+ ++ E KQ +E Q ++ + E + L + +K
Sbjct: 1437 SNAAAAALDKKQRNFDKILAEWKQKYEE-SQSELESSQKEARSLSTELFKLK-------- 1487
Query: 1077 RQKGYEEEIIH---FKKELR--EPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQA 1131
YEE + H FK+E + + + D E+ E + E V K L++ L A
Sbjct: 1488 --NAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSA 1545
Query: 1132 IMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASD---KRRNYNYRVVM 1188
+ + + E KI+R +E+ +I+++ + ++ D ++ N++ V+
Sbjct: 1546 LEEAEASLEHEEGKILR---------AQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVV 1596
Query: 1189 LKGDTALDMRGR 1200
T+LD R
Sbjct: 1597 DSLQTSLDAETR 1608
Score = 78.2 bits (191), Expect = 5e-14
Identities = 118/576 (20%), Positives = 257/576 (44%), Gaps = 84/576 (14%)
Query: 595 AKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQD-----FESDLDRLKEEI 649
A+ KE+A+ ++ I L++ E + E+K+ + ++ +++ D L +
Sbjct: 845 AETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAE 904
Query: 650 EKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTE---AELQEVISDLQSKLR 706
E+ + A + +L DE + + + + E +EL++ I DL+ L
Sbjct: 905 ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLA 964
Query: 707 LAPDKLKSTESELKKKEKRR---DEMLG-LVPMRQSIIDLKEKEIPELRNKLQNVNRDIQ 762
+ +TE+++K + DE++ L ++++ + ++ + +L+ + VN +
Sbjct: 965 KVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVN-SLS 1023
Query: 763 RLKNDIEEQ-ETLLGTIMPEE------ESAK------VCLTDVTIM----ERFQME--LK 803
+ K +E+Q + L G++ E+ E AK + LT +IM ++ Q+E LK
Sbjct: 1024 KSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLK 1083
Query: 804 DVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNR-------KLIQDQ 856
E I QQ +K++ D Q+ ++ +E Q +++ + ++E R KL D
Sbjct: 1084 KKEFDINQQNSKIE--DEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDL 1141
Query: 857 QEQIQHLKSTTNEL-KSEKLQISTNLQR-------RQQLEEQTVELSTEVQSLYRE---- 904
+++ + E + +QI N +R R+ LEE T++ +L ++
Sbjct: 1142 SRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADS 1201
Query: 905 IKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENY 964
+ + EQ+ L+ +K ++EK E K+ D + E++ ++ +
Sbjct: 1202 VAELGEQIDNLQRVKQKLEKEKSEF--------KLELDDVTSNMEQIIKAKANLEKVSRT 1253
Query: 965 IQDGKDDYKKQKETELNKVIAQLSECEKHKEKI-NEDMRLMRQDIDTQKIQERWLQDNLT 1023
++D ++Y+ +L + L++ + K+ E+ L RQ + + + + + L+
Sbjct: 1254 LEDQANEYR----VKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLS 1309
Query: 1024 LRKRNEELK-EVEEERK-----QHLKEMGQMQVLQMKSEHQKLEENIDNIKR-----NHN 1072
++ E+LK ++EEE K H + + ++ ++++ E ++R N
Sbjct: 1310 YTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSE 1369
Query: 1073 LALGRQKGYEEEIIHFKKELRE------PQFRDAEE 1102
+A R K YE + I +EL E + +DAEE
Sbjct: 1370 VAQWRTK-YETDAIQRTEELEEAKKKLAQRLQDAEE 1404
Score = 74.3 bits (181), Expect = 7e-13
Identities = 126/608 (20%), Positives = 259/608 (42%), Gaps = 85/608 (13%)
Query: 74 QETDVRAQIRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITRTKHGEKVSLSSKC 133
+ET+ +A+++ N E +A R+ T ++TE E + K +++ + +
Sbjct: 1351 EETEAKAELQRVLSKANSE-VAQWRTKYETDAIQRTE----ELEEAKKKLAQRLQDAEEA 1405
Query: 134 AEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQK---FDEIFSATRYIKALE 190
E SSL +K L N I D + AL +K FD+I + + K E
Sbjct: 1406 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQ-KYEE 1464
Query: 191 TLRQVRQTQGQ---------KVKE-YQMELKYLKQYKEKACEIRDQITSKEAQLTSS--- 237
+ ++ +Q + K+K Y+ L++L+ +K + ++++I+ QL
Sbjct: 1465 SQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKN 1524
Query: 238 ----KEIVKSYENELDPLKNRLKE----IEHNLSKIMKLDNEIKALDSRKKQMEKDNSEL 289
+++ K E E L++ L+E +EH KI++ E + +E+
Sbjct: 1525 VHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQI----------KAEI 1574
Query: 290 EEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVE 349
E K+ + DE++ NHQR V + L R ++ + + + + +E+ ++
Sbjct: 1575 ERKLAE----KDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQ 1630
Query: 350 QGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAK 409
A Q+ +++ SL++ TQ++LD R + +K +V R
Sbjct: 1631 LSHANRMAAEAQKQVKSLQSLLKD--TQIQLDDAVR---ANDDLKENIAIVERR------ 1679
Query: 410 TANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIEL--KSEILSKKQNELKNVKYELQ-Q 466
N L+ AE E L+ R +K +IE + ++L + L N K +++
Sbjct: 1680 --NNLLQ--AELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESD 1735
Query: 467 LEGSSDRILELDQELIKAERELSKAEKNSNV--ETLKMEVISLQNEKADLDRTLRKLDQE 524
L + E QE AE + KA ++ + E LK E Q+ A L+R + ++Q
Sbjct: 1736 LTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKE----QDTSAHLERMKKNMEQT 1791
Query: 525 MEQLNHHTTTRTQM------EMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLED 578
++ L H Q+ + L K +A E ++++ S+ G +++++++
Sbjct: 1792 IKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKE 1851
Query: 579 WLH---SKSKEINQTRDRLAKL-------NKELASSEQNKNHINNELKRKEEQLSSYEDK 628
+ K + + +D + KL ++ +E+ N ++ ++ + +L E++
Sbjct: 1852 LTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEER 1911
Query: 629 LFDVCGSQ 636
D+ SQ
Sbjct: 1912 A-DIAESQ 1918
Score = 45.4 bits (106), Expect = 3e-04
Identities = 66/357 (18%), Positives = 160/357 (44%), Gaps = 52/357 (14%)
Query: 845 KIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTV-------ELSTE 897
K+ K + E + + + E K + + RR++LEE+ V +L +
Sbjct: 833 KLYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQ 892
Query: 898 VQSLYREIKDAKEQVS-------PLETTLEKFQQ--EKEELINKKNTSNK-IAQDKLNDI 947
VQ+ + DA+E+ LE +++ + E EE +N + T+ K +D+ +++
Sbjct: 893 VQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSEL 952
Query: 948 KEKVKNIHGYMKDI--ENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMR 1005
K+ + ++ + + E + + K ++ L+++IA+L+ K K+ + E +
Sbjct: 953 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLT---KEKKALQEAHQQAL 1009
Query: 1006 QDIDTQKIQERWL-QDNLTLRKRNEELK-EVEEERKQHLK------------EMGQMQVL 1051
D+ ++ + L + + L ++ ++L+ +E+E+K + ++ Q ++
Sbjct: 1010 DDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIM 1069
Query: 1052 QMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEI--IHFKKELREPQFR--DAEEKYREM 1107
++++ +LEE + K+ ++ K +E++ + +K+L+E Q R + EE+
Sbjct: 1070 DLENDKLQLEEKLK--KKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAE 1127
Query: 1108 MIVMRTTELVNKDLDIYYKTLDQAI----------MKFHSMKMEEINKIIRDLWRST 1154
E + DL + + + + ++ + + E K+ RDL +T
Sbjct: 1128 RTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEAT 1184
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 127 bits (320), Expect = 5e-29
Identities = 231/1164 (19%), Positives = 476/1164 (40%), Gaps = 209/1164 (17%)
Query: 71 KVAQETDVRAQIRLQFRDVNGELIAVQRS---MVCTQKSKKTEFKTLEGVITRTKHGEKV 127
K+ ETD + ++F+D L + S +C K + ++ + ++ GE
Sbjct: 270 KLKTETD-KENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELT 328
Query: 128 SLSSKCAEIDREMISSLGVSKAV------LNNVIFCHQEDSNWPLSEGK---ALKQKFDE 178
+L + E D+ + + + A L + +E SN ++ K +K
Sbjct: 329 TLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHN 388
Query: 179 IFSATRYIKALETLRQVRQTQGQKVKEY-QMELKYLKQ----YKEKACEIRDQITSKE-A 232
+F ++ ET Q Q + Q+V+E + E+ +LKQ ++ +Q+ SK+ A
Sbjct: 389 VFQNKIHVSYQET--QQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSA 446
Query: 233 QLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEK 292
+L ++ NEL +L++ E ++ N +A K Q+++ EE
Sbjct: 447 ELNKLRQDYARLVNELTEKTGKLQQEE------VQKKNAEQAATQLKVQLQEAERRWEEV 500
Query: 293 MEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGR 352
+ + T E H+ ++ + K V E++ L+ S+L + S+ +EQ
Sbjct: 501 QSYIRKRTAE--------HEAAQQDLQSKFVAKENEVQSLH--SKLTDTLVSKQQLEQRL 550
Query: 353 LQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTAN 412
+QL + Q+ + +SL + D E+ + QI+ FH + Q + A
Sbjct: 551 MQLM-ESEQKRVNKEESLQMQVQ-----DILEQNEALKAQIQQFHSQIAA-QTSASVLAE 603
Query: 413 QLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSD 472
+L AEK+ KQI + D + + + L+ K+ ELK+++ L+
Sbjct: 604 ELHKVIAEKD----KQIKQTEDS-------LASERDRLTSKEEELKDIQNMNFLLKAEVQ 652
Query: 473 RILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHT 532
++ L E A EL K +++ V+ K+ ++ EQL H
Sbjct: 653 KLQALANEQAAAAHELEKMQQSVYVKDDKIRLLE-------------------EQLQHEI 693
Query: 533 TTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNK---KQLEDWLHSKSKEINQ 589
+ + + + D Q + +KS +L +L+ PNK +Q+E + K +++
Sbjct: 694 SNKMEEFKILND------QNKALKSE-VQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKT 746
Query: 590 TRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEI 649
+ L ++A+ E+ N I E SS ++ D+ Q+ + L EE+
Sbjct: 747 VEELLETGLIQVATKEEELNAIRTEN-------SSLTKEVQDLKAKQNDQVSFASLVEEL 799
Query: 650 EKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAP 709
+K + + + +++ V L+++L
Sbjct: 800 KKV----------------------------------IHEKDGKIKSVEELLEAELLKVA 825
Query: 710 DKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIE 769
+K K+ + +LK++ K E +G V + ++ ++ EL+N L+ + +K +E
Sbjct: 826 NKEKTVQ-DLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLE 884
Query: 770 EQETLLGT-------IMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLD 822
E+E L + E ES K + +V Q LK+ A A++ + +L+
Sbjct: 885 EKEKDLANTGKWLQDLQEENESLKAHVQEVA-----QHNLKE-----ASSASQFE--ELE 932
Query: 823 RTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQ 882
+++ E + + L S + +L+QD Q++ + KS +LK + Q +++
Sbjct: 933 IVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFP 992
Query: 883 RRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQD 942
++L + E E+ L+ E+ K+ V +++ E + ++ K+ QD
Sbjct: 993 PHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQD 1052
Query: 943 KLN---------------DIKEKVKN----------------IHGYMKDIENYI--QDGK 969
K+N + KE +K +HG+ K + + G
Sbjct: 1053 KVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGS 1112
Query: 970 DDYK----KQKETELNKVIAQLSECEKHKEKINEDMRLMRQ-DIDTQKIQERWL----QD 1020
++ K K KE + + QL ECEK+K + E ++++ ++ + +W +
Sbjct: 1113 EEVKVLEHKLKEADEMHTLLQL-ECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDES 1171
Query: 1021 NLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKG 1080
+ T+++ E+E ++ E ++ L+ + EH ++E ++R+
Sbjct: 1172 HKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERS---------T 1222
Query: 1081 YEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKM 1140
Y E+ K L E Q + ++ Y E + N++L++ L++ + K + +
Sbjct: 1223 YVTEVRELKDLLTELQ-KKLDDSYSEAV-------RQNEELNLLKAQLNETLTKLRT-EQ 1273
Query: 1141 EEINKIIRDLWRSTYRGQDIEYIE 1164
E K+ DL ++ Q +E I+
Sbjct: 1274 NERQKVAGDLHKAQ---QSLELIQ 1294
Score = 70.9 bits (172), Expect = 8e-12
Identities = 130/618 (21%), Positives = 267/618 (43%), Gaps = 92/618 (14%)
Query: 92 ELIAVQRSMVCTQKSKKTEFKTLEGVITR------TKHGEKVSLSSKCAEIDREMISSLG 145
EL+ V T++ + +T +T+ K ++VS +S E+ + + G
Sbjct: 749 ELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDG 808
Query: 146 VSKAV-----LNNVIFCHQEDSNWPLS-EGKALKQKFDEI-------FSATRYIKALETL 192
K+V + ++E + L E KALK++ + S T ++ L+ L
Sbjct: 809 KIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNL 868
Query: 193 RQVRQTQ------------------GQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQL 234
+ ++ Q G+ +++ Q E + LK + ++ + + S +Q
Sbjct: 869 LKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQF 928
Query: 235 TSSKEIVKSYENELDPLKNRLKEIEHNLSK----IMKLDNEIKALDSRKKQMEKDNSEL- 289
+ ++K ENEL L+ LKE E +LS + + +E K S+ +Q+++ N +
Sbjct: 929 EELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQA 988
Query: 290 -----EEKMEKVFQGTDEQLNDLYH---------NHQR----TVREKERKLVDCHRELEK 331
E++ KV +++++ L++ HQR +REK + ++ EK
Sbjct: 989 SSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEK 1048
Query: 332 LNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFER------ 385
+ ++ +N+ E + ++L+A + + + S+ +L+ L GFE+
Sbjct: 1049 MLQDK--VNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECM 1106
Query: 386 -GPFSERQIKNF-HKLVRERQEGEAKTANQL-----MNDFAEKETLKQKQIDEIRDKKTG 438
G ++K HKL ++ E T QL + AE E + QK + ++
Sbjct: 1107 AGTSGSEEVKVLEHKL---KEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENK 1163
Query: 439 LGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAE-KNSNV 497
++ + + + Q+ + + EL++L + I L +E E EL KAE + S
Sbjct: 1164 WKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTY 1223
Query: 498 ETLKMEVISLQNE-KADLDRTLRKLDQEMEQLNHHTTTRTQM-EMLTKDKADKDEQIRKI 555
T E+ L E + LD + + ++ E+LN + Q+ E LTK + +++E+ +K+
Sbjct: 1224 VTEVRELKDLLTELQKKLDDSYSEAVRQNEELN---LLKAQLNETLTKLRTEQNER-QKV 1279
Query: 556 -----KSRHSDEL--TSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNK 608
K++ S EL + ++ + +E+ S E ++ LN+ + +Q
Sbjct: 1280 AGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLL 1339
Query: 609 NHINNELKRKEEQLSSYE 626
+N +L +++E E
Sbjct: 1340 QAVNQQLTKEKEHYQVLE 1357
Score = 49.7 bits (117), Expect = 2e-05
Identities = 98/495 (19%), Positives = 191/495 (38%), Gaps = 81/495 (16%)
Query: 687 VFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGL-------VPMRQSI 739
+F E EV++ + + +L P K ++E KK +K+ + L VP +
Sbjct: 27 LFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKL 86
Query: 740 IDL----KEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESA-----KVCLT 790
D ++ P N ++ + +R K + +++ L ++ E +++ KV
Sbjct: 87 SDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPV 146
Query: 791 DVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNR 850
VT E ++K Q+ +K D D+ V+ + V SK
Sbjct: 147 PVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETL------------MVPSK----- 189
Query: 851 KLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQ--LEEQTVELSTEVQSL----YRE 904
+QE + + T E S K + S+ Q+ + ++E + +T + +
Sbjct: 190 -----RQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSP 244
Query: 905 IKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKN----------I 954
+ D +E + L+ + Q+ K T + A+ K D +K +
Sbjct: 245 VVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCV 304
Query: 955 HGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDID--TQK 1012
+K+ IQD KK + EL +I QL E +K + ED + TQ+
Sbjct: 305 VDLLKEKSGVIQDA---LKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQE 361
Query: 1013 IQERWLQDNLTLRKRNEELKEVEEERK--QHLKEMGQMQVLQMKSEHQKLEENIDNIKRN 1070
+ + N+ + + + + +E+E Q+ + + QM+ + Q++ E +
Sbjct: 362 MMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQM------ 415
Query: 1071 HNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQ 1130
E EI H K+E RDA + ++ EL NK Y + +++
Sbjct: 416 -----------EAEIAHLKQE--NGILRDAVSNTTNQLESKQSAEL-NKLRQDYARLVNE 461
Query: 1131 AIMKFHSMKMEEINK 1145
K ++ EE+ K
Sbjct: 462 LTEKTGKLQQEEVQK 476
Score = 42.0 bits (97), Expect = 0.004
Identities = 82/461 (17%), Positives = 190/461 (41%), Gaps = 35/461 (7%)
Query: 714 STESELKKKEKRRDEMLGLVPMRQSI-----------IDLKEKEIPELRNKLQNVNRDIQ 762
S+ E KKKEK++ +L +++S + + ++ P +
Sbjct: 109 SSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQK 168
Query: 763 RLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLD 822
+ KN ++Q+ + T+M + + + + + + E ++K + + K + + +D
Sbjct: 169 KSKNGSDDQDKKVETLMVPSKRQEA----LPLHQETKQESGSGKKKASSKKQKTENVFVD 224
Query: 823 RT-VQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNL 881
+ V K E+ L DQ E IQ KS T +LK+E + + +
Sbjct: 225 EPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQ--KSGTKKLKTETDKENAEV 282
Query: 882 QRRQQLEEQTVELSTE-----VQSLYRE----IKDAKEQVSPLE-TTLEKFQQEKEELIN 931
+ + L + +E V L +E I+DA ++ S E TTL QEK++L+
Sbjct: 283 KFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLA 342
Query: 932 KKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECE 991
+D+ + +++ + ++D +K+ NK+ E +
Sbjct: 343 AVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQ 402
Query: 992 KHKEKINEDMRLMRQDIDTQKIQERWLQD---NLTLRKRNEELKEVEEERKQHLKEMGQM 1048
+ + K + M +I K + L+D N T + +++ E+ + R+ + + + ++
Sbjct: 403 QMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNEL 462
Query: 1049 QVLQMKSEHQKLE-ENIDNIKRNHNLALGR-QKGYEEEIIHFKKELREPQF--RDAEEKY 1104
K + ++++ +N + + L ++ +EE + +K E + +D + K+
Sbjct: 463 TEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKF 522
Query: 1105 REMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINK 1145
+++ D + + L+Q +M+ + + +NK
Sbjct: 523 VAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNK 563
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.129 0.344
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,221,336
Number of Sequences: 37866
Number of extensions: 1986469
Number of successful extensions: 27774
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 384
Number of HSP's successfully gapped in prelim test: 1406
Number of HSP's that attempted gapping in prelim test: 10051
Number of HSP's gapped (non-prelim): 8322
length of query: 1312
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1198
effective length of database: 13,930,794
effective search space: 16689091212
effective search space used: 16689091212
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.