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Search of human proteins with 198041678
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|198041678 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 1 [Homo sapiens]
(1139 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|198041678 solute carrier family 12 (potassium-chloride transp... 2301 0.0
gi|11968148 solute carrier family 12 (potassium-chloride transpo... 2219 0.0
gi|123701900 solute carrier family 12 (potassium/chloride transp... 1584 0.0
gi|110224458 solute carrier family 12, member 6 isoform e [Homo ... 1558 0.0
gi|4826780 solute carrier family 12, member 6 isoform b [Homo sa... 1555 0.0
gi|110224456 solute carrier family 12, member 6 isoform d [Homo ... 1555 0.0
gi|110224454 solute carrier family 12, member 6 isoform c [Homo ... 1555 0.0
gi|110224452 solute carrier family 12, member 6 isoform c [Homo ... 1555 0.0
gi|110224449 solute carrier family 12, member 6 isoform a [Homo ... 1555 0.0
gi|4827006 solute carrier family 12, member 4 isoform a [Homo sa... 1508 0.0
gi|225579067 solute carrier family 12, member 4 isoform e [Homo ... 1506 0.0
gi|225579065 solute carrier family 12, member 4 isoform d [Homo ... 1506 0.0
gi|225579061 solute carrier family 12, member 4 isoform b [Homo ... 1491 0.0
gi|225579063 solute carrier family 12, member 4 isoform c [Homo ... 1473 0.0
gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo ... 225 2e-58
gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo ... 222 2e-57
gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo ... 222 2e-57
gi|4506975 solute carrier family 12 (sodium/potassium/chloride t... 221 3e-57
gi|134254459 sodium potassium chloride cotransporter 2 [Homo sap... 213 1e-54
gi|31881740 solute carrier family 12 (potassium/chloride transpo... 193 9e-49
gi|38569457 solute carrier family 12, member 8 [Homo sapiens] 100 8e-21
gi|33286430 solute carrier family 7 (cationic amino acid transpo... 45 5e-04
gi|33286428 solute carrier family 7 (cationic amino acid transpo... 45 5e-04
gi|195976805 hypoxia up-regulated 1 precursor [Homo sapiens] 42 0.003
gi|5453832 hypoxia up-regulated 1 precursor [Homo sapiens] 42 0.003
gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo s... 40 0.013
gi|187423910 solute carrier family 7, member 9 [Homo sapiens] 39 0.028
gi|7657591 solute carrier family 7, member 9 [Homo sapiens] 39 0.028
gi|56676330 HP1-BP74 [Homo sapiens] 39 0.037
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 38 0.063
>gi|198041678 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 1 [Homo sapiens]
Length = 1139
Score = 2301 bits (5963), Expect = 0.0
Identities = 1139/1139 (100%), Positives = 1139/1139 (100%)
Query: 1 MSRRFTVTSLPPAGPARSPDPESRRHSVADPRHLPGEDVKGDGNPKESSPFINSTDTEKG 60
MSRRFTVTSLPPAGPARSPDPESRRHSVADPRHLPGEDVKGDGNPKESSPFINSTDTEKG
Sbjct: 1 MSRRFTVTSLPPAGPARSPDPESRRHSVADPRHLPGEDVKGDGNPKESSPFINSTDTEKG 60
Query: 61 KEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRM 120
KEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRM
Sbjct: 61 KEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRM 120
Query: 121 GTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNG 180
GTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNG
Sbjct: 121 GTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNG 180
Query: 181 VVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAE 240
VVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAE
Sbjct: 181 VVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAE 240
Query: 241 DASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKS 300
DASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKS
Sbjct: 241 DASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKS 300
Query: 301 AFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNATCDEYFTR 360
AFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNATCDEYFTR
Sbjct: 301 AFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNATCDEYFTR 360
Query: 361 NNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDMT 420
NNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDMT
Sbjct: 361 NNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDMT 420
Query: 421 SYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACI 480
SYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACI
Sbjct: 421 SYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACI 480
Query: 481 EGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDG 540
EGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDG
Sbjct: 481 EGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDG 540
Query: 541 IVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACA 600
IVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACA
Sbjct: 541 IVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACA 600
Query: 601 VQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGA 660
VQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGA
Sbjct: 601 VQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGA 660
Query: 661 EKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQ 720
EKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQ
Sbjct: 661 EKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQ 720
Query: 721 LKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHL 780
LKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHL
Sbjct: 721 LKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHL 780
Query: 781 IQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGN 840
IQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGN
Sbjct: 781 IQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGN 840
Query: 841 PERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTT 900
PERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTT
Sbjct: 841 PERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTT 900
Query: 901 FLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDES 960
FLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDES
Sbjct: 901 FLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDES 960
Query: 961 RGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEG 1020
RGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEG
Sbjct: 961 RGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEG 1020
Query: 1021 ETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLN 1080
ETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLN
Sbjct: 1021 ETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLN 1080
Query: 1081 EVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS 1139
EVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS
Sbjct: 1081 EVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS 1139
>gi|11968148 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 2 [Homo sapiens]
Length = 1116
Score = 2219 bits (5750), Expect = 0.0
Identities = 1099/1099 (100%), Positives = 1099/1099 (100%)
Query: 41 GDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSRE 100
GDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSRE
Sbjct: 18 GDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSRE 77
Query: 101 HEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVF 160
HEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVF
Sbjct: 78 HEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVF 137
Query: 161 ICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYIL 220
ICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYIL
Sbjct: 138 ICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYIL 197
Query: 221 GTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFAL 280
GTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFAL
Sbjct: 198 GTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFAL 257
Query: 281 VFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRL 340
VFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRL
Sbjct: 258 VFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRL 317
Query: 341 WGLFCSSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSV 400
WGLFCSSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSV
Sbjct: 318 WGLFCSSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSV 377
Query: 401 GLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTIL 460
GLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTIL
Sbjct: 378 GLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTIL 437
Query: 461 AIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCG 520
AIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCG
Sbjct: 438 AIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCG 497
Query: 521 AGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEV 580
AGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEV
Sbjct: 498 AGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEV 557
Query: 581 APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYY 640
APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYY
Sbjct: 558 APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYY 617
Query: 641 ALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVL 700
ALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVL
Sbjct: 618 ALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVL 677
Query: 701 VRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEK 760
VRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEK
Sbjct: 678 VRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEK 737
Query: 761 VKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRE 820
VKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRE
Sbjct: 738 VKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRE 797
Query: 821 TTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMR 880
TTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMR
Sbjct: 798 TTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMR 857
Query: 881 IFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILK 940
IFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILK
Sbjct: 858 IFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILK 917
Query: 941 QMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQ 1000
QMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQ
Sbjct: 918 QMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQ 977
Query: 1001 SAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKP 1060
SAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKP
Sbjct: 978 SAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKP 1037
Query: 1061 EWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEH 1120
EWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEH
Sbjct: 1038 EWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEH 1097
Query: 1121 LDRVMLVRGGGREVITIYS 1139
LDRVMLVRGGGREVITIYS
Sbjct: 1098 LDRVMLVRGGGREVITIYS 1116
>gi|123701900 solute carrier family 12 (potassium/chloride
transporters), member 7 [Homo sapiens]
Length = 1083
Score = 1584 bits (4101), Expect = 0.0
Identities = 798/1140 (70%), Positives = 914/1140 (80%), Gaps = 58/1140 (5%)
Query: 1 MSRRFTVTSLPPAGPARSPDPESRRHSVADPRHL-PGEDVKGDGNPKESSPFINSTDTEK 59
M FTV + + R + P P GDGNP+E+SPF+N+ + E+
Sbjct: 1 MPTNFTVVPVEAHADGGGDETAERTEAPGTPEGPEPERPSPGDGNPRENSPFLNNVEVEQ 60
Query: 60 GKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPR 119
++GKNMALFEEEMD++PMVSSLL+ LANYTNL QG EHEE E + +++ +APR
Sbjct: 61 ESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEDEES---RRREAKAPR 117
Query: 120 MGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATN 179
MGTF+GVYLPCLQNI GVILFLRLTW+VG+AG++ESF +V +CC+CTMLTAISMSAIATN
Sbjct: 118 MGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIATN 177
Query: 180 GVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKA 239
GVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEI L Y+ P AIF+A
Sbjct: 178 GVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIFQA 237
Query: 240 EDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIK 299
E A GEAAAML+NMRVYGTC L MA VVFVGVKYVNK ALVFL CV+LSILAIYAGVIK
Sbjct: 238 EAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLSILAIYAGVIK 297
Query: 300 SAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNATCDEYFT 359
SAFDPP+ P+CLLGNRTLSR FD C K N + T+ LWGLFC+ +A CDEYF
Sbjct: 298 SAFDPPDIPVCLLGNRTLSRRSFDACVKAYGIHNNSATSALWGLFCNGSQPSAACDEYFI 357
Query: 360 RNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDM 419
+NNVTEIQGIPGAASG+ ENLWS+Y G VE+ G+ SV +A+ + PYV +D+
Sbjct: 358 QNNVTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVPSVPVAEESRASA-LPYVLTDI 416
Query: 420 TSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGAC 479
+ FTLLVGIYFPSVTGIMAGSNRSGDL+DAQKSIPTGTILAI TTS +Y+S +VLFGAC
Sbjct: 417 AASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGAC 476
Query: 480 IEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRD 539
IEGVVLRDKFGEA+ GNLV+G LAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAI+RD
Sbjct: 477 IEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARD 536
Query: 540 GIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLAC 599
GIVPFLQVFGHGKANGEPTWALLLT ICE GILIASLD VAPILSMFFLMCY+FVNLAC
Sbjct: 537 GIVPFLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLFVNLAC 596
Query: 600 AVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRG 659
AVQTLLRTPNWRPRF++YHWTLSFLGMSLCLALMFICSWYYAL AMLIAG IYKYIEYRG
Sbjct: 597 AVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRG 656
Query: 660 AEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTS 719
AEKEWGDGIRGLSL+AARYALLR+E GPPHTKNWRPQ+LV++ +D +Q V HP+LLS TS
Sbjct: 657 AEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTS 716
Query: 720 QLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSH 779
QLKAGKGLTIVGSVLEGT+L+ H +AQRAEE+IR LM EK KGFCQ+V+SS+LRDG+SH
Sbjct: 717 QLKAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSH 776
Query: 780 LIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPG 839
LIQS GLGGL+HNTVL+ WP +W+Q+++ +W+NF++ VR+TTA H ALLV KNV FP
Sbjct: 777 LIQSAGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQ 836
Query: 840 NPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLT 899
N ERF G IDVWWIVHDGGMLMLLPFLLR HKVWRKC+MRIFTVAQ+DDNSIQMKKDL
Sbjct: 837 NQERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQ 896
Query: 900 TFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDE 959
FLYHLRI+AEVEVVEM E+DISA+TYE+TL+MEQRSQ+LKQM L+KNE+ERE Q
Sbjct: 897 MFLYHLRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQMQLSKNEQEREAQ----- 951
Query: 960 SRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGE 1019
LIHD++ S +++ P
Sbjct: 952 ------------------------------------LIHDRNTASHTAAAARTQAPP--- 972
Query: 1020 GETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRL 1079
P+KV +TWT++K +AEK + S G KD FSMKP+ QSNVRRMHTAV+L
Sbjct: 973 ---TPDKVQMTWTREKLIAEKYRS-RDTSLSGFKDLFSMKPD-----QSNVRRMHTAVKL 1023
Query: 1080 NEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS 1139
N V++ KS+DA+LVLLNMPGPP+NR GDENYMEFLEVLTE L+RV+LVRGGGREVITIYS
Sbjct: 1024 NGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVITIYS 1083
>gi|110224458 solute carrier family 12, member 6 isoform e [Homo
sapiens]
Length = 1135
Score = 1558 bits (4033), Expect = 0.0
Identities = 781/1121 (69%), Positives = 906/1121 (80%), Gaps = 62/1121 (5%)
Query: 20 DPESRRHSVADPRHLPGEDVKGDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSP 79
DP S R S P + ++ DG+ K + ++N+++ E+G EY KN+ALFEEEMDT P
Sbjct: 76 DPPSDRTSH------PQDVIEDDGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRP 129
Query: 80 MVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVIL 139
VSSLL+ +ANYTNL QG++EHEEAEN GKKKP + P+MGTFMGVYLPCLQNIFGVIL
Sbjct: 130 KVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVIL 189
Query: 140 FLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEF 199
FLRLTWVVG AG++++F +V ICC CTMLTAISMSAIATNGVVPAGGSY+MISR+LGPEF
Sbjct: 190 FLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEF 249
Query: 200 GGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTC 259
GGAVGLCFYLGTTFA AMYILG IEI L Y+ P AIF ++DA E+AAMLNNMRVYGT
Sbjct: 250 GGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTA 309
Query: 260 VLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSR 319
L M VVF+GV+YVNKFA +FL CVI+SILAIYAG IKS+F PP+FP+C+LGNRTLS
Sbjct: 310 FLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSS 369
Query: 320 HGFDVCAKLAWEGNETVTTRLWGLFC-SSRFLNATCDEYFTRNNVTEIQGIPGAASGLIK 378
DVC+K N TV ++LWG FC SS+F NATCDEYF NNVT IQGIPG ASG+I
Sbjct: 370 RHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIIT 429
Query: 379 ENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIM 438
ENLWS+YL KG I+E+ S + ++H YV D+T+ FTLLVGI+FPSVTGIM
Sbjct: 430 ENLWSNYLPKGEIIEKPSAKSSDVLGS----LNHEYVLVDITTSFTLLVGIFFPSVTGIM 485
Query: 439 AGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLV 498
AGSNRSGDL+DAQKSIP GTILAI TTS VY+S+VVLFGACIEGVVLRDKFG+AV GNLV
Sbjct: 486 AGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLV 545
Query: 499 VGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPT 558
VGTL+WPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAI++D I+PFL+VFGH KANGEPT
Sbjct: 546 VGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPT 605
Query: 559 WALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYH 618
WALLLTA I E+GILIASLD VAPILSMFFLMCY+FVNLACA+QTLLRTPNWRPRFRYYH
Sbjct: 606 WALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYH 665
Query: 619 WTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARY 678
W LSF+GMS+CLALMFI SWYYA+VAM+IAG+IYKYIEY+GAEKEWGDGIRGLSLSAAR+
Sbjct: 666 WALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARF 725
Query: 679 ALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTF 738
ALLRLEEGPPHTKNWRPQLLVL+++D+D +V HP+LL+ SQLKAGKGLTIVGSV+ G F
Sbjct: 726 ALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNF 785
Query: 739 LENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGW 798
LEN+ +A AE++I+ LMEAEKVKGFCQ+V+++ LR+G+SHLIQS GLGG++HNTV++GW
Sbjct: 786 LENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGW 845
Query: 799 PRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDG 858
P WRQ ED + W+ FI VR TTA HLALLV KN+S FP N E+FSEG+IDVWWIVHDG
Sbjct: 846 PNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDG 905
Query: 859 GMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHE 918
GMLMLLPFLL+ HKVWRKC +RIFTVAQ++DNSIQMKKDL TFLYHLRI AEVEVVEMH+
Sbjct: 906 GMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHD 965
Query: 919 SDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNV 978
SDISAYTYE+TL+MEQRSQ+L+ M L+K ER+RE Q + D N+ LRL
Sbjct: 966 SDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDR-----------NSMLRLT- 1013
Query: 979 PEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVA 1038
S G + + E ET EKVH+TWTKDK +A
Sbjct: 1014 --------------------------------SIGSDEDEETETYQEKVHMTWTKDKYMA 1041
Query: 1039 EKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMP 1098
++G S EG +D +M+P+ QSNVRRMHTAV+LNEVIV KS +AKLVLLNMP
Sbjct: 1042 --SRGQKAKSMEGFQDLLNMRPD-----QSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMP 1094
Query: 1099 GPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS 1139
GPPRN GDENYMEFLEVLTE L+RV+LVRGGG EVITIYS
Sbjct: 1095 GPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1135
>gi|4826780 solute carrier family 12, member 6 isoform b [Homo
sapiens]
Length = 1099
Score = 1555 bits (4026), Expect = 0.0
Identities = 778/1123 (69%), Positives = 906/1123 (80%), Gaps = 60/1123 (5%)
Query: 18 SPDPESRRHSVADPRHLPGEDVKGDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDT 77
S +P+ ++S+ + DG+ K + ++N+++ E+G EY KN+ALFEEEMDT
Sbjct: 36 SDEPDLSQNSITGEH----SQLLDDGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDT 91
Query: 78 SPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGV 137
P VSSLL+ +ANYTNL QG++EHEEAEN GKKKP + P+MGTFMGVYLPCLQNIFGV
Sbjct: 92 RPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGV 151
Query: 138 ILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGP 197
ILFLRLTWVVG AG++++F +V ICC CTMLTAISMSAIATNGVVPAGGSY+MISR+LGP
Sbjct: 152 ILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGP 211
Query: 198 EFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYG 257
EFGGAVGLCFYLGTTFA AMYILG IEI L Y+ P AIF ++DA E+AAMLNNMRVYG
Sbjct: 212 EFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYG 271
Query: 258 TCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTL 317
T L M VVF+GV+YVNKFA +FL CVI+SILAIYAG IKS+F PP+FP+C+LGNRTL
Sbjct: 272 TAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTL 331
Query: 318 SRHGFDVCAKLAWEGNETVTTRLWGLFC-SSRFLNATCDEYFTRNNVTEIQGIPGAASGL 376
S DVC+K N TV ++LWG FC SS+F NATCDEYF NNVT IQGIPG ASG+
Sbjct: 332 SSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGI 391
Query: 377 IKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTG 436
I ENLWS+YL KG I+E+ S + ++H YV D+T+ FTLLVGI+FPSVTG
Sbjct: 392 ITENLWSNYLPKGEIIEKPSAKSSDVLGS----LNHEYVLVDITTSFTLLVGIFFPSVTG 447
Query: 437 IMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGN 496
IMAGSNRSGDL+DAQKSIP GTILAI TTS VY+S+VVLFGACIEGVVLRDKFG+AV GN
Sbjct: 448 IMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGN 507
Query: 497 LVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGE 556
LVVGTL+WPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAI++D I+PFL+VFGH KANGE
Sbjct: 508 LVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGE 567
Query: 557 PTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRY 616
PTWALLLTA I E+GILIASLD VAPILSMFFLMCY+FVNLACA+QTLLRTPNWRPRFRY
Sbjct: 568 PTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRY 627
Query: 617 YHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAA 676
YHW LSF+GMS+CLALMFI SWYYA+VAM+IAG+IYKYIEY+GAEKEWGDGIRGLSLSAA
Sbjct: 628 YHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAA 687
Query: 677 RYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEG 736
R+ALLRLEEGPPHTKNWRPQLLVL+++D+D +V HP+LL+ SQLKAGKGLTIVGSV+ G
Sbjct: 688 RFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVG 747
Query: 737 TFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLV 796
FLEN+ +A AE++I+ LMEAEKVKGFCQ+V+++ LR+G+SHLIQS GLGG++HNTV++
Sbjct: 748 NFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVM 807
Query: 797 GWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVH 856
GWP WRQ ED + W+ FI VR TTA HLALLV KN+S FP N E+FSEG+IDVWWIVH
Sbjct: 808 GWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVH 867
Query: 857 DGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEM 916
DGGMLMLLPFLL+ HKVWRKC +RIFTVAQ++DNSIQMKKDL TFLYHLRI AEVEVVEM
Sbjct: 868 DGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEM 927
Query: 917 HESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRL 976
H+SDISAYTYE+TL+MEQRSQ+L+ M L+K ER+RE Q + D N+ LRL
Sbjct: 928 HDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDR-----------NSMLRL 976
Query: 977 NVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKS 1036
S G + + E ET EKVH+TWTKDK
Sbjct: 977 T---------------------------------SIGSDEDEETETYQEKVHMTWTKDKY 1003
Query: 1037 VAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLN 1096
+A ++G S EG +D +M+P+ QSNVRRMHTAV+LNEVIV KS +AKLVLLN
Sbjct: 1004 MA--SRGQKAKSMEGFQDLLNMRPD-----QSNVRRMHTAVKLNEVIVNKSHEAKLVLLN 1056
Query: 1097 MPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS 1139
MPGPPRN GDENYMEFLEVLTE L+RV+LVRGGG EVITIYS
Sbjct: 1057 MPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1099
>gi|110224456 solute carrier family 12, member 6 isoform d [Homo
sapiens]
Length = 1141
Score = 1555 bits (4025), Expect = 0.0
Identities = 775/1099 (70%), Positives = 897/1099 (81%), Gaps = 56/1099 (5%)
Query: 42 DGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREH 101
DG+ K + ++N+++ E+G EY KN+ALFEEEMDT P VSSLL+ +ANYTNL QG++EH
Sbjct: 98 DGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEH 157
Query: 102 EEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFI 161
EEAEN GKKKP + P+MGTFMGVYLPCLQNIFGVILFLRLTWVVG AG++++F +V I
Sbjct: 158 EEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLI 217
Query: 162 CCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILG 221
CC CTMLTAISMSAIATNGVVPAGGSY+MISR+LGPEFGGAVGLCFYLGTTFA AMYILG
Sbjct: 218 CCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILG 277
Query: 222 TIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALV 281
IEI L Y+ P AIF ++DA E+AAMLNNMRVYGT L M VVF+GV+YVNKFA +
Sbjct: 278 AIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASL 337
Query: 282 FLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLW 341
FL CVI+SILAIYAG IKS+F PP+FP+C+LGNRTLS DVC+K N TV ++LW
Sbjct: 338 FLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLW 397
Query: 342 GLFC-SSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSV 400
G FC SS+F NATCDEYF NNVT IQGIPG ASG+I ENLWS+YL KG I+E+ S
Sbjct: 398 GFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSS 457
Query: 401 GLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTIL 460
+ ++H YV D+T+ FTLLVGI+FPSVTGIMAGSNRSGDL+DAQKSIP GTIL
Sbjct: 458 DVLGS----LNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTIL 513
Query: 461 AIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCG 520
AI TTS VY+S+VVLFGACIEGVVLRDKFG+AV GNLVVGTL+WPSPWVIVIGSFFSTCG
Sbjct: 514 AILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCG 573
Query: 521 AGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEV 580
AGLQSLTGAPRLLQAI++D I+PFL+VFGH KANGEPTWALLLTA I E+GILIASLD V
Sbjct: 574 AGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLV 633
Query: 581 APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYY 640
APILSMFFLMCY+FVNLACA+QTLLRTPNWRPRFRYYHW LSF+GMS+CLALMFI SWYY
Sbjct: 634 APILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYY 693
Query: 641 ALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVL 700
A+VAM+IAG+IYKYIEY+GAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHTKNWRPQLLVL
Sbjct: 694 AIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVL 753
Query: 701 VRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEK 760
+++D+D +V HP+LL+ SQLKAGKGLTIVGSV+ G FLEN+ +A AE++I+ LMEAEK
Sbjct: 754 LKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEK 813
Query: 761 VKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRE 820
VKGFCQ+V+++ LR+G+SHLIQS GLGG++HNTV++GWP WRQ ED + W+ FI VR
Sbjct: 814 VKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRV 873
Query: 821 TTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMR 880
TTA HLALLV KN+S FP N E+FSEG+IDVWWIVHDGGMLMLLPFLL+ HKVWRKC +R
Sbjct: 874 TTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIR 933
Query: 881 IFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILK 940
IFTVAQ++DNSIQMKKDL TFLYHLRI AEVEVVEMH+SDISAYTYE+TL+MEQRSQ+L+
Sbjct: 934 IFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLR 993
Query: 941 QMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQ 1000
M L+K ER+RE Q + D N+ LRL
Sbjct: 994 HMRLSKTERDREAQLVKDR-----------NSMLRLT----------------------- 1019
Query: 1001 SAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKP 1060
S G + + E ET EKVH+TWTKDK +A ++G S EG +D +M+P
Sbjct: 1020 ----------SIGSDEDEETETYQEKVHMTWTKDKYMA--SRGQKAKSMEGFQDLLNMRP 1067
Query: 1061 EWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEH 1120
+ QSNVRRMHTAV+LNEVIV KS +AKLVLLNMPGPPRN GDENYMEFLEVLTE
Sbjct: 1068 D-----QSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEG 1122
Query: 1121 LDRVMLVRGGGREVITIYS 1139
L+RV+LVRGGG EVITIYS
Sbjct: 1123 LERVLLVRGGGSEVITIYS 1141
>gi|110224454 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 1555 bits (4025), Expect = 0.0
Identities = 775/1099 (70%), Positives = 897/1099 (81%), Gaps = 56/1099 (5%)
Query: 42 DGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREH 101
DG+ K + ++N+++ E+G EY KN+ALFEEEMDT P VSSLL+ +ANYTNL QG++EH
Sbjct: 48 DGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEH 107
Query: 102 EEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFI 161
EEAEN GKKKP + P+MGTFMGVYLPCLQNIFGVILFLRLTWVVG AG++++F +V I
Sbjct: 108 EEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLI 167
Query: 162 CCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILG 221
CC CTMLTAISMSAIATNGVVPAGGSY+MISR+LGPEFGGAVGLCFYLGTTFA AMYILG
Sbjct: 168 CCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILG 227
Query: 222 TIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALV 281
IEI L Y+ P AIF ++DA E+AAMLNNMRVYGT L M VVF+GV+YVNKFA +
Sbjct: 228 AIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASL 287
Query: 282 FLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLW 341
FL CVI+SILAIYAG IKS+F PP+FP+C+LGNRTLS DVC+K N TV ++LW
Sbjct: 288 FLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLW 347
Query: 342 GLFC-SSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSV 400
G FC SS+F NATCDEYF NNVT IQGIPG ASG+I ENLWS+YL KG I+E+ S
Sbjct: 348 GFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSS 407
Query: 401 GLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTIL 460
+ ++H YV D+T+ FTLLVGI+FPSVTGIMAGSNRSGDL+DAQKSIP GTIL
Sbjct: 408 DVLGS----LNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTIL 463
Query: 461 AIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCG 520
AI TTS VY+S+VVLFGACIEGVVLRDKFG+AV GNLVVGTL+WPSPWVIVIGSFFSTCG
Sbjct: 464 AILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCG 523
Query: 521 AGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEV 580
AGLQSLTGAPRLLQAI++D I+PFL+VFGH KANGEPTWALLLTA I E+GILIASLD V
Sbjct: 524 AGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLV 583
Query: 581 APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYY 640
APILSMFFLMCY+FVNLACA+QTLLRTPNWRPRFRYYHW LSF+GMS+CLALMFI SWYY
Sbjct: 584 APILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYY 643
Query: 641 ALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVL 700
A+VAM+IAG+IYKYIEY+GAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHTKNWRPQLLVL
Sbjct: 644 AIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVL 703
Query: 701 VRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEK 760
+++D+D +V HP+LL+ SQLKAGKGLTIVGSV+ G FLEN+ +A AE++I+ LMEAEK
Sbjct: 704 LKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEK 763
Query: 761 VKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRE 820
VKGFCQ+V+++ LR+G+SHLIQS GLGG++HNTV++GWP WRQ ED + W+ FI VR
Sbjct: 764 VKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRV 823
Query: 821 TTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMR 880
TTA HLALLV KN+S FP N E+FSEG+IDVWWIVHDGGMLMLLPFLL+ HKVWRKC +R
Sbjct: 824 TTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIR 883
Query: 881 IFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILK 940
IFTVAQ++DNSIQMKKDL TFLYHLRI AEVEVVEMH+SDISAYTYE+TL+MEQRSQ+L+
Sbjct: 884 IFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLR 943
Query: 941 QMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQ 1000
M L+K ER+RE Q + D N+ LRL
Sbjct: 944 HMRLSKTERDREAQLVKDR-----------NSMLRLT----------------------- 969
Query: 1001 SAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKP 1060
S G + + E ET EKVH+TWTKDK +A ++G S EG +D +M+P
Sbjct: 970 ----------SIGSDEDEETETYQEKVHMTWTKDKYMA--SRGQKAKSMEGFQDLLNMRP 1017
Query: 1061 EWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEH 1120
+ QSNVRRMHTAV+LNEVIV KS +AKLVLLNMPGPPRN GDENYMEFLEVLTE
Sbjct: 1018 D-----QSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEG 1072
Query: 1121 LDRVMLVRGGGREVITIYS 1139
L+RV+LVRGGG EVITIYS
Sbjct: 1073 LERVLLVRGGGSEVITIYS 1091
>gi|110224452 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 1555 bits (4025), Expect = 0.0
Identities = 775/1099 (70%), Positives = 897/1099 (81%), Gaps = 56/1099 (5%)
Query: 42 DGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREH 101
DG+ K + ++N+++ E+G EY KN+ALFEEEMDT P VSSLL+ +ANYTNL QG++EH
Sbjct: 48 DGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEH 107
Query: 102 EEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFI 161
EEAEN GKKKP + P+MGTFMGVYLPCLQNIFGVILFLRLTWVVG AG++++F +V I
Sbjct: 108 EEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLI 167
Query: 162 CCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILG 221
CC CTMLTAISMSAIATNGVVPAGGSY+MISR+LGPEFGGAVGLCFYLGTTFA AMYILG
Sbjct: 168 CCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILG 227
Query: 222 TIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALV 281
IEI L Y+ P AIF ++DA E+AAMLNNMRVYGT L M VVF+GV+YVNKFA +
Sbjct: 228 AIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASL 287
Query: 282 FLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLW 341
FL CVI+SILAIYAG IKS+F PP+FP+C+LGNRTLS DVC+K N TV ++LW
Sbjct: 288 FLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLW 347
Query: 342 GLFC-SSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSV 400
G FC SS+F NATCDEYF NNVT IQGIPG ASG+I ENLWS+YL KG I+E+ S
Sbjct: 348 GFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSS 407
Query: 401 GLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTIL 460
+ ++H YV D+T+ FTLLVGI+FPSVTGIMAGSNRSGDL+DAQKSIP GTIL
Sbjct: 408 DVLGS----LNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTIL 463
Query: 461 AIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCG 520
AI TTS VY+S+VVLFGACIEGVVLRDKFG+AV GNLVVGTL+WPSPWVIVIGSFFSTCG
Sbjct: 464 AILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCG 523
Query: 521 AGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEV 580
AGLQSLTGAPRLLQAI++D I+PFL+VFGH KANGEPTWALLLTA I E+GILIASLD V
Sbjct: 524 AGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLV 583
Query: 581 APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYY 640
APILSMFFLMCY+FVNLACA+QTLLRTPNWRPRFRYYHW LSF+GMS+CLALMFI SWYY
Sbjct: 584 APILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYY 643
Query: 641 ALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVL 700
A+VAM+IAG+IYKYIEY+GAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHTKNWRPQLLVL
Sbjct: 644 AIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVL 703
Query: 701 VRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEK 760
+++D+D +V HP+LL+ SQLKAGKGLTIVGSV+ G FLEN+ +A AE++I+ LMEAEK
Sbjct: 704 LKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEK 763
Query: 761 VKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRE 820
VKGFCQ+V+++ LR+G+SHLIQS GLGG++HNTV++GWP WRQ ED + W+ FI VR
Sbjct: 764 VKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRV 823
Query: 821 TTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMR 880
TTA HLALLV KN+S FP N E+FSEG+IDVWWIVHDGGMLMLLPFLL+ HKVWRKC +R
Sbjct: 824 TTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIR 883
Query: 881 IFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILK 940
IFTVAQ++DNSIQMKKDL TFLYHLRI AEVEVVEMH+SDISAYTYE+TL+MEQRSQ+L+
Sbjct: 884 IFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLR 943
Query: 941 QMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQ 1000
M L+K ER+RE Q + D N+ LRL
Sbjct: 944 HMRLSKTERDREAQLVKDR-----------NSMLRLT----------------------- 969
Query: 1001 SAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKP 1060
S G + + E ET EKVH+TWTKDK +A ++G S EG +D +M+P
Sbjct: 970 ----------SIGSDEDEETETYQEKVHMTWTKDKYMA--SRGQKAKSMEGFQDLLNMRP 1017
Query: 1061 EWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEH 1120
+ QSNVRRMHTAV+LNEVIV KS +AKLVLLNMPGPPRN GDENYMEFLEVLTE
Sbjct: 1018 D-----QSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEG 1072
Query: 1121 LDRVMLVRGGGREVITIYS 1139
L+RV+LVRGGG EVITIYS
Sbjct: 1073 LERVLLVRGGGSEVITIYS 1091
>gi|110224449 solute carrier family 12, member 6 isoform a [Homo
sapiens]
Length = 1150
Score = 1555 bits (4025), Expect = 0.0
Identities = 775/1099 (70%), Positives = 897/1099 (81%), Gaps = 56/1099 (5%)
Query: 42 DGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREH 101
DG+ K + ++N+++ E+G EY KN+ALFEEEMDT P VSSLL+ +ANYTNL QG++EH
Sbjct: 107 DGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEH 166
Query: 102 EEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFI 161
EEAEN GKKKP + P+MGTFMGVYLPCLQNIFGVILFLRLTWVVG AG++++F +V I
Sbjct: 167 EEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLI 226
Query: 162 CCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILG 221
CC CTMLTAISMSAIATNGVVPAGGSY+MISR+LGPEFGGAVGLCFYLGTTFA AMYILG
Sbjct: 227 CCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILG 286
Query: 222 TIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALV 281
IEI L Y+ P AIF ++DA E+AAMLNNMRVYGT L M VVF+GV+YVNKFA +
Sbjct: 287 AIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASL 346
Query: 282 FLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLW 341
FL CVI+SILAIYAG IKS+F PP+FP+C+LGNRTLS DVC+K N TV ++LW
Sbjct: 347 FLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLW 406
Query: 342 GLFC-SSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSV 400
G FC SS+F NATCDEYF NNVT IQGIPG ASG+I ENLWS+YL KG I+E+ S
Sbjct: 407 GFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSS 466
Query: 401 GLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTIL 460
+ ++H YV D+T+ FTLLVGI+FPSVTGIMAGSNRSGDL+DAQKSIP GTIL
Sbjct: 467 DVLGS----LNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTIL 522
Query: 461 AIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCG 520
AI TTS VY+S+VVLFGACIEGVVLRDKFG+AV GNLVVGTL+WPSPWVIVIGSFFSTCG
Sbjct: 523 AILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCG 582
Query: 521 AGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEV 580
AGLQSLTGAPRLLQAI++D I+PFL+VFGH KANGEPTWALLLTA I E+GILIASLD V
Sbjct: 583 AGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLV 642
Query: 581 APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYY 640
APILSMFFLMCY+FVNLACA+QTLLRTPNWRPRFRYYHW LSF+GMS+CLALMFI SWYY
Sbjct: 643 APILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYY 702
Query: 641 ALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVL 700
A+VAM+IAG+IYKYIEY+GAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHTKNWRPQLLVL
Sbjct: 703 AIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVL 762
Query: 701 VRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEK 760
+++D+D +V HP+LL+ SQLKAGKGLTIVGSV+ G FLEN+ +A AE++I+ LMEAEK
Sbjct: 763 LKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEK 822
Query: 761 VKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRE 820
VKGFCQ+V+++ LR+G+SHLIQS GLGG++HNTV++GWP WRQ ED + W+ FI VR
Sbjct: 823 VKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRV 882
Query: 821 TTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMR 880
TTA HLALLV KN+S FP N E+FSEG+IDVWWIVHDGGMLMLLPFLL+ HKVWRKC +R
Sbjct: 883 TTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIR 942
Query: 881 IFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILK 940
IFTVAQ++DNSIQMKKDL TFLYHLRI AEVEVVEMH+SDISAYTYE+TL+MEQRSQ+L+
Sbjct: 943 IFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLR 1002
Query: 941 QMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQ 1000
M L+K ER+RE Q + D N+ LRL
Sbjct: 1003 HMRLSKTERDREAQLVKDR-----------NSMLRLT----------------------- 1028
Query: 1001 SAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKP 1060
S G + + E ET EKVH+TWTKDK +A ++G S EG +D +M+P
Sbjct: 1029 ----------SIGSDEDEETETYQEKVHMTWTKDKYMA--SRGQKAKSMEGFQDLLNMRP 1076
Query: 1061 EWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEH 1120
+ QSNVRRMHTAV+LNEVIV KS +AKLVLLNMPGPPRN GDENYMEFLEVLTE
Sbjct: 1077 D-----QSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEG 1131
Query: 1121 LDRVMLVRGGGREVITIYS 1139
L+RV+LVRGGG EVITIYS
Sbjct: 1132 LERVLLVRGGGSEVITIYS 1150
>gi|4827006 solute carrier family 12, member 4 isoform a [Homo
sapiens]
Length = 1085
Score = 1508 bits (3903), Expect = 0.0
Identities = 761/1105 (68%), Positives = 885/1105 (80%), Gaps = 56/1105 (5%)
Query: 37 EDVKGDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQ 96
+D G GN +ESSPF++ + +G +Y +N+ALFEEE+D P VSSLL L +YTNL Q
Sbjct: 35 DDSDGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQ 94
Query: 97 GSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESF 156
G++EHEEAE+ EG +++ +AP MGT MGVYLPCLQNIFGVILFLRLTW+VG AG++++
Sbjct: 95 GAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQAL 154
Query: 157 CMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGA 216
+V ICC CT+LTAISMSAIATNGVVPAGGSY+MISRSLGPEFGGAVGLCFYLGTTFA A
Sbjct: 155 LIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAA 214
Query: 217 MYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVN 276
MYILG IEILL Y+ P AIF A + A LNNMRVYGT LT M VVFVGVKYVN
Sbjct: 215 MYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVN 274
Query: 277 KFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETV 336
KFA +FL CVI+SIL+IYAG IKS FDPP FP+C+LGNRTLSR FD+CAK A NETV
Sbjct: 275 KFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETV 334
Query: 337 TTRLWGLFCSSRFLNA-TCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERS 395
T+LW FC S L +CD YF NNVTEI GIPGAA+G+++ENLWS+YL KG IVE+
Sbjct: 335 ATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKH 394
Query: 396 GMTSVGLADGTPIDMDHP-YVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSI 454
G+ S AD + P YV +D+ + FT+LVGI+FPSVTGIMAGSNRSGDLRDAQKSI
Sbjct: 395 GLPS---ADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSI 451
Query: 455 PTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGS 514
P GTILAI TTS VY SSVVLFGACIEGVVLRDK+G+ V+ NLVVGTLAWPSPWVIVIGS
Sbjct: 452 PVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGS 511
Query: 515 FFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILI 574
FFSTCGAGLQSLTGAPRLLQAI++D I+PFL+VFGHGK NGEPTWALLLTA I E+GILI
Sbjct: 512 FFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILI 571
Query: 575 ASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMF 634
ASLD VAPILSMFFLMCY+FVNLACAVQTLLRTPNWRPRF+YYHW LSFLGMSLCLALMF
Sbjct: 572 ASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMF 631
Query: 635 ICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWR 694
+ SWYYALVAMLIAG+IYKYIEY+GAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWR
Sbjct: 632 VSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWR 691
Query: 695 PQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRR 754
PQLLVL+++D+D +V +P+LL+ SQLKAGKGLTIVGSV++G+FLE++ +AQ AE++I+
Sbjct: 692 PQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKN 751
Query: 755 LMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNF 814
+ME EKVKGFCQVV++S +R+G++HLIQS GLGG++HN+V++GWP WRQ ED + W+ F
Sbjct: 752 MMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTF 811
Query: 815 IELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVW 874
I+ VR TTA HLALLV KN++ +P N ER+ EG IDVWWIVHDGGMLMLLPFLLR HKVW
Sbjct: 812 IDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVW 871
Query: 875 RKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQ 934
RKC+MRIFTVAQMDDNSIQMKKDL FLYHLR+ AEVEVVEMH SDISAYTYE+TL+MEQ
Sbjct: 872 RKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQ 931
Query: 935 RSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEV 994
RSQ+L+QM LTK ERERE Q + D ++ LRL E D E+
Sbjct: 932 RSQMLRQMRLTKTEREREAQLVKDR-----------HSALRL---ESLYSDEED------ 971
Query: 995 QLIHDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKD 1054
E +K+ +TWT+DK + E PS + + ++
Sbjct: 972 ------------------------ESAVGADKIQMTWTRDKYMTE-TWDPSH-APDNFRE 1005
Query: 1055 FFSMKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFL 1114
+KP+ QSNVRRMHTAV+LNEVIV +S DA+LVLLNMPGPPRN GDENYMEFL
Sbjct: 1006 LVHIKPD-----QSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFL 1060
Query: 1115 EVLTEHLDRVMLVRGGGREVITIYS 1139
EVLTE L+RV+LVRGGGREVITIYS
Sbjct: 1061 EVLTEGLERVLLVRGGGREVITIYS 1085
>gi|225579067 solute carrier family 12, member 4 isoform e [Homo
sapiens]
Length = 1054
Score = 1506 bits (3898), Expect = 0.0
Identities = 760/1101 (69%), Positives = 883/1101 (80%), Gaps = 56/1101 (5%)
Query: 41 GDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSRE 100
G GN +ESSPF++ + +G +Y +N+ALFEEE+D P VSSLL L +YTNL QG++E
Sbjct: 8 GHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKE 67
Query: 101 HEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVF 160
HEEAE+ EG +++ +AP MGT MGVYLPCLQNIFGVILFLRLTW+VG AG++++ +V
Sbjct: 68 HEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVL 127
Query: 161 ICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYIL 220
ICC CT+LTAISMSAIATNGVVPAGGSY+MISRSLGPEFGGAVGLCFYLGTTFA AMYIL
Sbjct: 128 ICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYIL 187
Query: 221 GTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFAL 280
G IEILL Y+ P AIF A + A LNNMRVYGT LT M VVFVGVKYVNKFA
Sbjct: 188 GAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFAS 247
Query: 281 VFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRL 340
+FL CVI+SIL+IYAG IKS FDPP FP+C+LGNRTLSR FD+CAK A NETV T+L
Sbjct: 248 LFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQL 307
Query: 341 WGLFCSSRFLNA-TCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTS 399
W FC S L +CD YF NNVTEI GIPGAA+G+++ENLWS+YL KG IVE+ G+ S
Sbjct: 308 WSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPS 367
Query: 400 VGLADGTPIDMDHP-YVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGT 458
AD + P YV +D+ + FT+LVGI+FPSVTGIMAGSNRSGDLRDAQKSIP GT
Sbjct: 368 ---ADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGT 424
Query: 459 ILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFST 518
ILAI TTS VY SSVVLFGACIEGVVLRDK+G+ V+ NLVVGTLAWPSPWVIVIGSFFST
Sbjct: 425 ILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFST 484
Query: 519 CGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLD 578
CGAGLQSLTGAPRLLQAI++D I+PFL+VFGHGK NGEPTWALLLTA I E+GILIASLD
Sbjct: 485 CGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLD 544
Query: 579 EVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSW 638
VAPILSMFFLMCY+FVNLACAVQTLLRTPNWRPRF+YYHW LSFLGMSLCLALMF+ SW
Sbjct: 545 MVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSW 604
Query: 639 YYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLL 698
YYALVAMLIAG+IYKYIEY+GAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLL
Sbjct: 605 YYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLL 664
Query: 699 VLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEA 758
VL+++D+D +V +P+LL+ SQLKAGKGLTIVGSV++G+FLE++ +AQ AE++I+ +ME
Sbjct: 665 VLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEI 724
Query: 759 EKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELV 818
EKVKGFCQVV++S +R+G++HLIQS GLGG++HN+V++GWP WRQ ED + W+ FI+ V
Sbjct: 725 EKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTV 784
Query: 819 RETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCK 878
R TTA HLALLV KN++ +P N ER+ EG IDVWWIVHDGGMLMLLPFLLR HKVWRKC+
Sbjct: 785 RCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCR 844
Query: 879 MRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQI 938
MRIFTVAQMDDNSIQMKKDL FLYHLR+ AEVEVVEMH SDISAYTYE+TL+MEQRSQ+
Sbjct: 845 MRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQM 904
Query: 939 LKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIH 998
L+QM LTK ERERE Q + D ++ LRL E D E+
Sbjct: 905 LRQMRLTKTEREREAQLVKDR-----------HSALRL---ESLYSDEED---------- 940
Query: 999 DQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSM 1058
E +K+ +TWT+DK + E PS + + ++ +
Sbjct: 941 --------------------ESAVGADKIQMTWTRDKYMTE-TWDPSH-APDNFRELVHI 978
Query: 1059 KPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLT 1118
KP+ QSNVRRMHTAV+LNEVIV +S DA+LVLLNMPGPPRN GDENYMEFLEVLT
Sbjct: 979 KPD-----QSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLT 1033
Query: 1119 EHLDRVMLVRGGGREVITIYS 1139
E L+RV+LVRGGGREVITIYS
Sbjct: 1034 EGLERVLLVRGGGREVITIYS 1054
>gi|225579065 solute carrier family 12, member 4 isoform d [Homo
sapiens]
Length = 1079
Score = 1506 bits (3898), Expect = 0.0
Identities = 760/1101 (69%), Positives = 883/1101 (80%), Gaps = 56/1101 (5%)
Query: 41 GDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSRE 100
G GN +ESSPF++ + +G +Y +N+ALFEEE+D P VSSLL L +YTNL QG++E
Sbjct: 33 GHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKE 92
Query: 101 HEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVF 160
HEEAE+ EG +++ +AP MGT MGVYLPCLQNIFGVILFLRLTW+VG AG++++ +V
Sbjct: 93 HEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVL 152
Query: 161 ICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYIL 220
ICC CT+LTAISMSAIATNGVVPAGGSY+MISRSLGPEFGGAVGLCFYLGTTFA AMYIL
Sbjct: 153 ICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYIL 212
Query: 221 GTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFAL 280
G IEILL Y+ P AIF A + A LNNMRVYGT LT M VVFVGVKYVNKFA
Sbjct: 213 GAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFAS 272
Query: 281 VFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRL 340
+FL CVI+SIL+IYAG IKS FDPP FP+C+LGNRTLSR FD+CAK A NETV T+L
Sbjct: 273 LFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQL 332
Query: 341 WGLFCSSRFLNA-TCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTS 399
W FC S L +CD YF NNVTEI GIPGAA+G+++ENLWS+YL KG IVE+ G+ S
Sbjct: 333 WSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPS 392
Query: 400 VGLADGTPIDMDHP-YVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGT 458
AD + P YV +D+ + FT+LVGI+FPSVTGIMAGSNRSGDLRDAQKSIP GT
Sbjct: 393 ---ADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGT 449
Query: 459 ILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFST 518
ILAI TTS VY SSVVLFGACIEGVVLRDK+G+ V+ NLVVGTLAWPSPWVIVIGSFFST
Sbjct: 450 ILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFST 509
Query: 519 CGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLD 578
CGAGLQSLTGAPRLLQAI++D I+PFL+VFGHGK NGEPTWALLLTA I E+GILIASLD
Sbjct: 510 CGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLD 569
Query: 579 EVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSW 638
VAPILSMFFLMCY+FVNLACAVQTLLRTPNWRPRF+YYHW LSFLGMSLCLALMF+ SW
Sbjct: 570 MVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSW 629
Query: 639 YYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLL 698
YYALVAMLIAG+IYKYIEY+GAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLL
Sbjct: 630 YYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLL 689
Query: 699 VLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEA 758
VL+++D+D +V +P+LL+ SQLKAGKGLTIVGSV++G+FLE++ +AQ AE++I+ +ME
Sbjct: 690 VLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEI 749
Query: 759 EKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELV 818
EKVKGFCQVV++S +R+G++HLIQS GLGG++HN+V++GWP WRQ ED + W+ FI+ V
Sbjct: 750 EKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTV 809
Query: 819 RETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCK 878
R TTA HLALLV KN++ +P N ER+ EG IDVWWIVHDGGMLMLLPFLLR HKVWRKC+
Sbjct: 810 RCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCR 869
Query: 879 MRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQI 938
MRIFTVAQMDDNSIQMKKDL FLYHLR+ AEVEVVEMH SDISAYTYE+TL+MEQRSQ+
Sbjct: 870 MRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQM 929
Query: 939 LKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIH 998
L+QM LTK ERERE Q + D ++ LRL E D E+
Sbjct: 930 LRQMRLTKTEREREAQLVKDR-----------HSALRL---ESLYSDEED---------- 965
Query: 999 DQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSM 1058
E +K+ +TWT+DK + E PS + + ++ +
Sbjct: 966 --------------------ESAVGADKIQMTWTRDKYMTE-TWDPSH-APDNFRELVHI 1003
Query: 1059 KPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLT 1118
KP+ QSNVRRMHTAV+LNEVIV +S DA+LVLLNMPGPPRN GDENYMEFLEVLT
Sbjct: 1004 KPD-----QSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLT 1058
Query: 1119 EHLDRVMLVRGGGREVITIYS 1139
E L+RV+LVRGGGREVITIYS
Sbjct: 1059 EGLERVLLVRGGGREVITIYS 1079
>gi|225579061 solute carrier family 12, member 4 isoform b [Homo
sapiens]
Length = 1079
Score = 1491 bits (3859), Expect = 0.0
Identities = 755/1105 (68%), Positives = 879/1105 (79%), Gaps = 62/1105 (5%)
Query: 37 EDVKGDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQ 96
+D G GN +ESSPF++ + +G +Y +N+ALFEEE+D P VSSLL L +YTNL Q
Sbjct: 35 DDSDGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQ 94
Query: 97 GSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESF 156
G++EHEEAE+ EG +++ +AP MGT MGVYLPCLQNIFGVILFLRLTW+VG AG++++
Sbjct: 95 GAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQAL 154
Query: 157 CMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGA 216
+V ICC CT+LTAISMSAIATNGVVPAGGSY+MISRSLGPEFGGAVGLCFYLGTTFA A
Sbjct: 155 LIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAA 214
Query: 217 MYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVN 276
MYILG IEILL Y+ P AIF A + A LNNMRVYGT LT M VVFVGVKYVN
Sbjct: 215 MYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVN 274
Query: 277 KFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETV 336
KFA +FL CVI+SIL+IYAG IKS FDPP FP+C+LGNRTLSR FD+CAK A NETV
Sbjct: 275 KFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETV 334
Query: 337 TTRLWGLFCSSRFLNA-TCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERS 395
T+LW FC S L +CD YF NNVTEI GIPGAA+G+++ENLWS+YL KG IVE+
Sbjct: 335 ATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKH 394
Query: 396 GMTSVGLADGTPIDMDHP-YVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSI 454
G+ S AD + P YV +D+ + FT+LVGI+FPSVTGIMAGSNRSGDLRDAQKSI
Sbjct: 395 GLPS---ADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSI 451
Query: 455 PTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGS 514
P GTILAI TTS VY SSVVLFGACIEGVVLRDK+G+ V+ NLVVGTLAWPSPWVIVIGS
Sbjct: 452 PVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGS 511
Query: 515 FFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILI 574
FFSTCGAGLQSLTGAPRLLQAI++D I+PFL+VFGHGK NGEPTWALLLTA I E+GILI
Sbjct: 512 FFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILI 571
Query: 575 ASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMF 634
ASLD VAPILSMFFLMCY+FVNLACAVQTLLRTPNWRPRF+YYHW LSFLGMSLCLALMF
Sbjct: 572 ASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMF 631
Query: 635 ICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWR 694
+ SWYYALVAMLIAG+IYKYIEY+GAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWR
Sbjct: 632 VSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWR 691
Query: 695 PQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRR 754
PQLLVL+++D+D +V +P+LL+ SQLKAGKGLTIVGSV++G+FLE++ +AQ AE++I+
Sbjct: 692 PQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKN 751
Query: 755 LMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNF 814
+ME EKVKGFCQVV++S +R+G++HLIQS GLGG++HN+V++GWP WRQ ED + W+ F
Sbjct: 752 MMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTF 811
Query: 815 IELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVW 874
I+ VR TTA HLALLV KN++ +P N ER+ EG IDVWWIVHDGGMLMLLPFLLR HKVW
Sbjct: 812 IDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVW 871
Query: 875 RKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQ 934
RKC+MRIFTVAQMDDNSIQMKKDL FLYHLR+ AE H SDISAYTYE+TL+MEQ
Sbjct: 872 RKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAE------HNSDISAYTYERTLMMEQ 925
Query: 935 RSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEV 994
RSQ+L+QM LTK ERERE Q + D ++ LRL E D E+
Sbjct: 926 RSQMLRQMRLTKTEREREAQLVKDR-----------HSALRL---ESLYSDEED------ 965
Query: 995 QLIHDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKD 1054
E +K+ +TWT+DK + E PS + + ++
Sbjct: 966 ------------------------ESAVGADKIQMTWTRDKYMTE-TWDPSH-APDNFRE 999
Query: 1055 FFSMKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFL 1114
+KP+ QSNVRRMHTAV+LNEVIV +S DA+LVLLNMPGPPRN GDENYMEFL
Sbjct: 1000 LVHIKPD-----QSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFL 1054
Query: 1115 EVLTEHLDRVMLVRGGGREVITIYS 1139
EVLTE L+RV+LVRGGGREVITIYS
Sbjct: 1055 EVLTEGLERVLLVRGGGREVITIYS 1079
>gi|225579063 solute carrier family 12, member 4 isoform c [Homo
sapiens]
Length = 1087
Score = 1473 bits (3813), Expect = 0.0
Identities = 745/1069 (69%), Positives = 860/1069 (80%), Gaps = 56/1069 (5%)
Query: 73 EEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQ 132
EE+D P VSSLL L +YTNL QG++EHEEAE+ EG +++ +AP MGT MGVYLPCLQ
Sbjct: 73 EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ 132
Query: 133 NIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMIS 192
NIFGVILFLRLTW+VG AG++++ +V ICC CT+LTAISMSAIATNGVVPAGGSY+MIS
Sbjct: 133 NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS 192
Query: 193 RSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNN 252
RSLGPEFGGAVGLCFYLGTTFA AMYILG IEILL Y+ P AIF A + A LNN
Sbjct: 193 RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN 252
Query: 253 MRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLL 312
MRVYGT LT M VVFVGVKYVNKFA +FL CVI+SIL+IYAG IKS FDPP FP+C+L
Sbjct: 253 MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML 312
Query: 313 GNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNA-TCDEYFTRNNVTEIQGIPG 371
GNRTLSR FD+CAK A NETV T+LW FC S L +CD YF NNVTEI GIPG
Sbjct: 313 GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 372
Query: 372 AASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHP-YVFSDMTSYFTLLVGIY 430
AA+G+++ENLWS+YL KG IVE+ G+ S AD + P YV +D+ + FT+LVGI+
Sbjct: 373 AAAGVLQENLWSAYLEKGDIVEKHGLPS---ADAPSLKESLPLYVVADIATSFTVLVGIF 429
Query: 431 FPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFG 490
FPSVTGIMAGSNRSGDLRDAQKSIP GTILAI TTS VY SSVVLFGACIEGVVLRDK+G
Sbjct: 430 FPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYG 489
Query: 491 EAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGH 550
+ V+ NLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAI++D I+PFL+VFGH
Sbjct: 490 DGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGH 549
Query: 551 GKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNW 610
GK NGEPTWALLLTA I E+GILIASLD VAPILSMFFLMCY+FVNLACAVQTLLRTPNW
Sbjct: 550 GKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNW 609
Query: 611 RPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRG 670
RPRF+YYHW LSFLGMSLCLALMF+ SWYYALVAMLIAG+IYKYIEY+GAEKEWGDGIRG
Sbjct: 610 RPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRG 669
Query: 671 LSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIV 730
LSLSAARYALLRLEEGPPHTKNWRPQLLVL+++D+D +V +P+LL+ SQLKAGKGLTIV
Sbjct: 670 LSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIV 729
Query: 731 GSVLEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQ 790
GSV++G+FLE++ +AQ AE++I+ +ME EKVKGFCQVV++S +R+G++HLIQS GLGG++
Sbjct: 730 GSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMR 789
Query: 791 HNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSID 850
HN+V++GWP WRQ ED + W+ FI+ VR TTA HLALLV KN++ +P N ER+ EG ID
Sbjct: 790 HNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHID 849
Query: 851 VWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAE 910
VWWIVHDGGMLMLLPFLLR HKVWRKC+MRIFTVAQMDDNSIQMKKDL FLYHLR+ AE
Sbjct: 850 VWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAE 909
Query: 911 VEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPA 970
VEVVEMH SDISAYTYE+TL+MEQRSQ+L+QM LTK ERERE Q + D
Sbjct: 910 VEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDR----------- 958
Query: 971 NTRLRLNVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLT 1030
++ LRL E D E+ E +K+ +T
Sbjct: 959 HSALRL---ESLYSDEED------------------------------ESAVGADKIQMT 985
Query: 1031 WTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDA 1090
WT+DK + E PS + + ++ +KP+ QSNVRRMHTAV+LNEVIV +S DA
Sbjct: 986 WTRDKYMTE-TWDPSH-APDNFRELVHIKPD-----QSNVRRMHTAVKLNEVIVTRSHDA 1038
Query: 1091 KLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS 1139
+LVLLNMPGPPRN GDENYMEFLEVLTE L+RV+LVRGGGREVITIYS
Sbjct: 1039 RLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1087
>gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo
sapiens]
Length = 1021
Score = 225 bits (573), Expect = 2e-58
Identities = 161/557 (28%), Positives = 253/557 (45%), Gaps = 86/557 (15%)
Query: 426 LVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVL 485
+ I+FPS TGI+AG+N SGDL+D +IP GT++AI T+ Y++ G+C V+
Sbjct: 343 MFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC----VV 398
Query: 486 RDKFGEAVNGNLVVGT-----LAWPSPW------------------------------VI 510
RD G +N + G LA W +I
Sbjct: 399 RDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLI 457
Query: 511 VIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKA-NGEPTWALLLTACICE 569
G F +T + L L A ++ Q + D + P + FG G N EP LL I
Sbjct: 458 TAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAV 517
Query: 570 IGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLC 629
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G +
Sbjct: 518 AFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIIS 577
Query: 630 LALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPH 689
+ +MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 578 VVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDH 637
Query: 690 TKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAE 749
KN+RPQ LVL P L+ L I G VL G + P+ Q
Sbjct: 638 IKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIA 693
Query: 750 ESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQ 809
+ + K+K F VI+ +LR GV L+Q+ GLG ++ N ++VG+ +NW Q
Sbjct: 694 NGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPA 752
Query: 810 TWRNFIELVRETTAGHLALLVTK-----NVSMFPG---NP-----ERFSEGS-------- 848
T ++I ++ + + + V + NVS NP E E S
Sbjct: 753 TVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARVDPKAL 812
Query: 849 ------------------IDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDN 890
ID++W+ DGG+ +L+P+LL + W KCK+R+F Q+ +
Sbjct: 813 VKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQI-NR 871
Query: 891 SIQMKKDLTTFLYHLRI 907
Q +K + + L R+
Sbjct: 872 MDQERKAIISLLSKFRL 888
Score = 120 bits (302), Expect = 6e-27
Identities = 65/204 (31%), Positives = 111/204 (54%), Gaps = 13/204 (6%)
Query: 103 EAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFIC 162
E E +K P + R G GV + C+ NI+GVIL+LRL W+ AGI+ ++ ++ +
Sbjct: 119 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 178
Query: 163 CSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGT 222
+ T +T +S+SAI+TNG V +GG+Y++ISRSLGPE GG++GL F AM+ +G
Sbjct: 179 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 238
Query: 223 IEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVF 282
E + L ++ +N++R+ G +T + + G+++ +K ++F
Sbjct: 239 AETVRDLL---------QEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLF 289
Query: 283 LGCVILSILAIYAGVIKSAFDPPN 306
L I+ +A + PP+
Sbjct: 290 ----FLVIMVSFANYLVGTLIPPS 309
Score = 47.4 bits (111), Expect = 8e-05
Identities = 26/77 (33%), Positives = 46/77 (59%), Gaps = 2/77 (2%)
Query: 1063 ENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHL- 1121
E + ++ V+ + VRLNE+++ SRDA L+++ +P + + YM +LE L++ L
Sbjct: 944 EEITKNRVKSLRQ-VRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLR 1002
Query: 1122 DRVMLVRGGGREVITIY 1138
V+L+RG V+T Y
Sbjct: 1003 PPVILIRGNQENVLTFY 1019
>gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo
sapiens]
Length = 1029
Score = 222 bits (565), Expect = 2e-57
Identities = 160/566 (28%), Positives = 254/566 (44%), Gaps = 95/566 (16%)
Query: 426 LVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVL 485
+ I+FPS TGI+AG+N SGDL+D +IP GT++AI T+ Y++ G+C V+
Sbjct: 342 MFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC----VV 397
Query: 486 RDKFGEAVNGNLVVGT-----LAWPSPW------------------------------VI 510
RD G +N + G LA W +I
Sbjct: 398 RDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLI 456
Query: 511 VIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKA-NGEPTWALLLTACICE 569
G F +T + L L A ++ Q + D + P + FG G N EP LL I
Sbjct: 457 TAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAV 516
Query: 570 IGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLC 629
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G +
Sbjct: 517 AFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIIS 576
Query: 630 LALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPH 689
+ +MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 577 VVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDH 636
Query: 690 TKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAE 749
KN+RPQ LVL P L+ L I G VL G + P+ Q
Sbjct: 637 IKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIA 692
Query: 750 ESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQ 809
+ + K+K F VI+ +LR GV L+Q+ GLG ++ N ++VG+ +NW Q
Sbjct: 693 NGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPA 751
Query: 810 TWRNFIELVRETTAGHLALLVTK-----NVSMFPG---NP---------ERFSEG----- 847
T ++I ++ + + + V + NVS NP E + G
Sbjct: 752 TVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSV 811
Query: 848 --------------------------SIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRI 881
+ID++W+ DGG+ +L+P+LL + W KCK+R+
Sbjct: 812 SGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRV 871
Query: 882 FTVAQMDDNSIQMKKDLTTFLYHLRI 907
F Q+ + Q +K + + L R+
Sbjct: 872 FVGGQI-NRMDQERKAIISLLSKFRL 896
Score = 120 bits (302), Expect = 6e-27
Identities = 65/204 (31%), Positives = 111/204 (54%), Gaps = 13/204 (6%)
Query: 103 EAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFIC 162
E E +K P + R G GV + C+ NI+GVIL+LRL W+ AGI+ ++ ++ +
Sbjct: 118 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 177
Query: 163 CSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGT 222
+ T +T +S+SAI+TNG V +GG+Y++ISRSLGPE GG++GL F AM+ +G
Sbjct: 178 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 237
Query: 223 IEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVF 282
E + L ++ +N++R+ G +T + + G+++ +K ++F
Sbjct: 238 AETVRDLL---------QEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLF 288
Query: 283 LGCVILSILAIYAGVIKSAFDPPN 306
L I+ +A + PP+
Sbjct: 289 ----FLVIMVSFANYLVGTLIPPS 308
Score = 47.4 bits (111), Expect = 8e-05
Identities = 26/77 (33%), Positives = 46/77 (59%), Gaps = 2/77 (2%)
Query: 1063 ENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHL- 1121
E + ++ V+ + VRLNE+++ SRDA L+++ +P + + YM +LE L++ L
Sbjct: 952 EEITKNRVKSLRQ-VRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLR 1010
Query: 1122 DRVMLVRGGGREVITIY 1138
V+L+RG V+T Y
Sbjct: 1011 PPVILIRGNQENVLTFY 1027
>gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo
sapiens]
Length = 1030
Score = 222 bits (565), Expect = 2e-57
Identities = 160/566 (28%), Positives = 254/566 (44%), Gaps = 95/566 (16%)
Query: 426 LVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVL 485
+ I+FPS TGI+AG+N SGDL+D +IP GT++AI T+ Y++ G+C V+
Sbjct: 343 MFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC----VV 398
Query: 486 RDKFGEAVNGNLVVGT-----LAWPSPW------------------------------VI 510
RD G +N + G LA W +I
Sbjct: 399 RDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLI 457
Query: 511 VIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKA-NGEPTWALLLTACICE 569
G F +T + L L A ++ Q + D + P + FG G N EP LL I
Sbjct: 458 TAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAV 517
Query: 570 IGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLC 629
I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G +
Sbjct: 518 AFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIIS 577
Query: 630 LALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPH 689
+ +MF+ +W+ AL+A+ + + Y+ Y+ E WG ++ S + A + L E H
Sbjct: 578 VVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDH 637
Query: 690 TKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAE 749
KN+RPQ LVL P L+ L I G VL G + P+ Q
Sbjct: 638 IKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIA 693
Query: 750 ESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQ 809
+ + K+K F VI+ +LR GV L+Q+ GLG ++ N ++VG+ +NW Q
Sbjct: 694 NGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNW-QSAHPA 752
Query: 810 TWRNFIELVRETTAGHLALLVTK-----NVSMFPG---NP---------ERFSEG----- 847
T ++I ++ + + + V + NVS NP E + G
Sbjct: 753 TVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGARPSV 812
Query: 848 --------------------------SIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRI 881
+ID++W+ DGG+ +L+P+LL + W KCK+R+
Sbjct: 813 SGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRV 872
Query: 882 FTVAQMDDNSIQMKKDLTTFLYHLRI 907
F Q+ + Q +K + + L R+
Sbjct: 873 FVGGQI-NRMDQERKAIISLLSKFRL 897
Score = 120 bits (302), Expect = 6e-27
Identities = 65/204 (31%), Positives = 111/204 (54%), Gaps = 13/204 (6%)
Query: 103 EAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFIC 162
E E +K P + R G GV + C+ NI+GVIL+LRL W+ AGI+ ++ ++ +
Sbjct: 119 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 178
Query: 163 CSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGT 222
+ T +T +S+SAI+TNG V +GG+Y++ISRSLGPE GG++GL F AM+ +G
Sbjct: 179 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 238
Query: 223 IEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVF 282
E + L ++ +N++R+ G +T + + G+++ +K ++F
Sbjct: 239 AETVRDLL---------QEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLF 289
Query: 283 LGCVILSILAIYAGVIKSAFDPPN 306
L I+ +A + PP+
Sbjct: 290 ----FLVIMVSFANYLVGTLIPPS 309
Score = 47.4 bits (111), Expect = 8e-05
Identities = 26/77 (33%), Positives = 46/77 (59%), Gaps = 2/77 (2%)
Query: 1063 ENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHL- 1121
E + ++ V+ + VRLNE+++ SRDA L+++ +P + + YM +LE L++ L
Sbjct: 953 EEITKNRVKSLRQ-VRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLR 1011
Query: 1122 DRVMLVRGGGREVITIY 1138
V+L+RG V+T Y
Sbjct: 1012 PPVILIRGNQENVLTFY 1028
>gi|4506975 solute carrier family 12 (sodium/potassium/chloride
transporters), member 2 [Homo sapiens]
Length = 1212
Score = 221 bits (563), Expect = 3e-57
Identities = 140/427 (32%), Positives = 218/427 (51%), Gaps = 47/427 (11%)
Query: 416 FSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVL 475
F + ++F++ I+FP+ TGI+AG+N SGDL D Q +IP GT+LAI T+ VY+ V
Sbjct: 481 FREEETFFSVFA-IFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVS 539
Query: 476 FGACIEGVVLRDKFGEA----------------------------------VNGNLVVGT 501
G+C V+RD G +N V+
Sbjct: 540 VGSC----VVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSM 595
Query: 502 LAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVF--GHGKANGEPTW 559
++ +P +I G F +T + L SL AP++ QA+ +D I P Q+F G+GK N EP
Sbjct: 596 VSGFTP-LISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGK-NNEPLR 653
Query: 560 ALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHW 619
+LT I ILIA L+ +API+S FFL Y +N + +L ++P WRP F+YY+
Sbjct: 654 GYILTFLIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNM 713
Query: 620 TLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYA 679
+S LG LC +MF+ +W+ AL+ +I +Y Y+ Y+ + WG + L+ A
Sbjct: 714 WISLLGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQH 773
Query: 680 LLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFL 739
+RL H KN+RPQ LV+ + P LL L GL I G V G
Sbjct: 774 SIRLSGVEDHVKNFRPQCLVMTGAPNSR----PALLHLVHDFTKNVGLMICGHVHMGPRR 829
Query: 740 ENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWP 799
+ + + +R + K+K F V + +LR+G +L+Q+ GLG ++ NT+++G+
Sbjct: 830 QAMKEMSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFK 889
Query: 800 RNWRQKE 806
++W Q +
Sbjct: 890 KDWLQAD 896
Score = 122 bits (306), Expect = 2e-27
Identities = 66/172 (38%), Positives = 101/172 (58%), Gaps = 9/172 (5%)
Query: 119 RMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIAT 178
+ G GV + C+ NI+GV+LF+RL+W+VG AGI S ++ + T +T +S SAIAT
Sbjct: 284 KFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIAT 343
Query: 179 NGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFK 238
NG V GG+YY+ISRSLGPEFGGA+GL F A AMY++G E ++ L +
Sbjct: 344 NGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMI 403
Query: 239 AEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSI 290
E +N++R+ G + + + G+++ K +V L ++L+I
Sbjct: 404 DE---------INDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAI 446
Score = 53.9 bits (128), Expect = 8e-07
Identities = 31/110 (28%), Positives = 65/110 (59%), Gaps = 10/110 (9%)
Query: 846 EGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQM-KKDLTTFLYH 904
+ +IDVWW+ DGG+ +L+P+LL K W+ CK+R+F ++ N I ++ + T L
Sbjct: 1021 KNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKI--NRIDHDRRAMATLLSK 1078
Query: 905 LRIT-AEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREI 953
RI +++ V+ DI+ ++ ++ + +I++ L ++++E++I
Sbjct: 1079 FRIDFSDIMVL----GDINTKPKKENIIAFE--EIIEPYRLHEDDKEQDI 1122
Score = 46.6 bits (109), Expect = 1e-04
Identities = 21/68 (30%), Positives = 41/68 (60%)
Query: 1072 RMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGG 1131
+ + +RLNE++ + S A ++++++P + YM +LE L++ L ++LVRG
Sbjct: 1145 KTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNH 1204
Query: 1132 REVITIYS 1139
+ V+T YS
Sbjct: 1205 QSVLTFYS 1212
>gi|134254459 sodium potassium chloride cotransporter 2 [Homo
sapiens]
Length = 1099
Score = 213 bits (541), Expect = 1e-54
Identities = 138/445 (31%), Positives = 214/445 (48%), Gaps = 45/445 (10%)
Query: 423 FTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEG 482
F + I+FP+ TGI+AG+N SGDL D Q +IP GT+LAI T+ Y+ + GAC
Sbjct: 380 FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGAC--- 436
Query: 483 VVLRDKFGEA---------VNGNLVVG----------------------TLAWPSPW--V 509
V+RD G NG+ G ++ S + +
Sbjct: 437 -VVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPL 495
Query: 510 IVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVF--GHGKANGEPTWALLLTACI 567
I G F +T + L SL AP++ QA+ +D I LQ F G+GK N EP +LT I
Sbjct: 496 ITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGK-NNEPLRGYILTFLI 554
Query: 568 CEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMS 627
ILIA L+ +API+S FFL Y +N +C + ++P WRP + Y+ +S G
Sbjct: 555 AMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAV 614
Query: 628 LCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGP 687
LC A+MF+ +W+ A++ +I +Y Y+ + + WG + LS +A L L
Sbjct: 615 LCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVE 674
Query: 688 PHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQR 747
H KN+RPQ +VL + P LL +T GL I V G +
Sbjct: 675 DHVKNFRPQCIVLT----GGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNS 730
Query: 748 AEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKED 807
+ + K+K F V + RDGV L+Q+ GLG ++ NT+++G+ +NWR K
Sbjct: 731 GMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWR-KAP 789
Query: 808 HQTWRNFIELVRETTAGHLALLVTK 832
N++ ++ + + +++ +
Sbjct: 790 LTEIENYVGIIHDAFDFEIGVVIVR 814
Score = 127 bits (318), Expect = 8e-29
Identities = 78/251 (31%), Positives = 129/251 (51%), Gaps = 26/251 (10%)
Query: 48 SSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENN 107
S P +N + E KN+A+ D +AN +P G + E E++
Sbjct: 122 SGPKVNRPSLLEIHEQLAKNVAVTPSSADR----------VANGDGIP-GDEQAENKEDD 170
Query: 108 EGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTM 167
+ G K G GV + C+ NI+GV+LF+RL+W+VG AGI ++ + T
Sbjct: 171 QAGVVK------FGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTS 224
Query: 168 LTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILL 227
+T +S SAIATNG V GG+YY+ISRSLGPEFGG++GL F A AMY++G E ++
Sbjct: 225 ITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVV 284
Query: 228 AYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVI 287
L +++ N++R+ G+ + + + G+++ K ++ L ++
Sbjct: 285 DLL---------KESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILL 335
Query: 288 LSILAIYAGVI 298
++I + G +
Sbjct: 336 IAIANFFIGTV 346
Score = 59.3 bits (142), Expect = 2e-08
Identities = 42/117 (35%), Positives = 67/117 (57%), Gaps = 13/117 (11%)
Query: 1023 DPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEV 1082
+P ++H + KD + AEK K +P I D E E + + + R+ VRLNE+
Sbjct: 996 EPYRLHES-CKDLTTAEKLKRETPWK---ITD-----AELEAVKEKSYRQ----VRLNEL 1042
Query: 1083 IVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS 1139
+ + SR A L++L++P + D YM +LE+LT++L V+LVRG + V+T YS
Sbjct: 1043 LQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099
Score = 58.5 bits (140), Expect = 3e-08
Identities = 31/132 (23%), Positives = 64/132 (48%), Gaps = 3/132 (2%)
Query: 846 EGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFT---VAQMDDNSIQMKKDLTTFL 902
+G+IDVWW+ DGG+ +L+P++L K W+ CK+RI+ + ++++ I M L+ F
Sbjct: 908 KGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFR 967
Query: 903 YHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRG 962
+ + + + S +E+ + + + K + + + ITD
Sbjct: 968 IKFADIHIIGDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWKITDAELE 1027
Query: 963 SIRRKNPANTRL 974
+++ K+ RL
Sbjct: 1028 AVKEKSYRQVRL 1039
>gi|31881740 solute carrier family 12 (potassium/chloride
transporters), member 9 [Homo sapiens]
Length = 914
Score = 193 bits (490), Expect = 9e-49
Identities = 156/549 (28%), Positives = 252/549 (45%), Gaps = 71/549 (12%)
Query: 423 FTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEG 482
F + + F TGIMAG+N SG+L+D ++IP GTI+A+A T VY+ L +
Sbjct: 267 FASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDR 326
Query: 483 VVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIV 542
+L++ +G WP +++IG + + A + SL GA R+L A++RD +
Sbjct: 327 TLLQEDYG------FFRAISLWPP--LVLIGIYATALSASMSSLIGASRILHALARDDLF 378
Query: 543 PFLQVFGHGKANGEPTWALLLTAC-ICEIGILIASLDEVAPILSMFFLMCYMFVNLACAV 601
+ + G WA +L + + ++ +L L+ +A ++++F+L+ Y V+L+C
Sbjct: 379 GVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLS 438
Query: 602 QTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAE 661
PN+RP F + W LG++ CL +MF+ S A ++L+ GL+ + RG
Sbjct: 439 LEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLAALLTARGGP 498
Query: 662 KEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQL 721
WG + L R LLRL+ H K WRPQLL+LV + LL L +QL
Sbjct: 499 SSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGA----LPLLRLANQL 554
Query: 722 KAGKGLTIVGSVLEGTFLENHPQ--AQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSH 779
K G GL ++G V G L++ P Q + L++ +VK F + +S ++R G H
Sbjct: 555 KKG-GLYVLGHVTLGD-LDSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGAQH 612
Query: 780 LIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHL------------- 826
L++ GLGG++ NT+++G+ + ++ T F E T G
Sbjct: 613 LLRISGLGGMKPNTLVLGFYDDAPPQDHFLTDPAFSEPADSTREGSSPALSTLFPPPRAP 672
Query: 827 -----------------ALLVTKNVSMFPGN----PERFSEGS--------IDVW----- 852
AL + KNV + + PER S GS +DVW
Sbjct: 673 GSPRALNPQDYVATVADALKMNKNVVLARASGALPPERLSRGSGGTSQLHHVDVWPLNLL 732
Query: 853 -------WIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHL 905
++ G L+ + +L W ++RIF + + L L L
Sbjct: 733 RPRGGPGYVDVCGLFLLQMATILGMVPAWHSARLRIFLCLGPREAPGAAEGRLRALLSQL 792
Query: 906 RITAEVEVV 914
RI AEV+ V
Sbjct: 793 RIRAEVQEV 801
Score = 108 bits (270), Expect = 3e-23
Identities = 51/121 (42%), Positives = 80/121 (66%)
Query: 107 NEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCT 166
N G A ++ TF+GV +P + ++F +++FLR+ +VVG AG++++ M+ +
Sbjct: 24 NGAGGPGGASARKLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFIL 83
Query: 167 MLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIL 226
LT +S+ AIATNG V GG+Y+MISR+LGPE GG++GL FYL A+ +LG +E +
Sbjct: 84 ALTVLSVCAIATNGAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESV 143
Query: 227 L 227
L
Sbjct: 144 L 144
>gi|38569457 solute carrier family 12, member 8 [Homo sapiens]
Length = 714
Score = 100 bits (249), Expect = 8e-21
Identities = 59/182 (32%), Positives = 103/182 (56%), Gaps = 10/182 (5%)
Query: 416 FSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVL 475
+S S+FT+ G++FP+ TG+MAG N GDLR+ SIP G++ A+ + +YI V L
Sbjct: 227 YSPGESFFTVF-GVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFL 285
Query: 476 FGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQA 535
GA LR F A +L+ ++ ++G + S+ + + L GAPR+LQ
Sbjct: 286 LGAICTREALRYDFLIAEKVSLM--------GFLFLLGLYISSLASCMGGLYGAPRILQC 337
Query: 536 ISRDGIVPFLQVFGHGKA-NGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMF 594
I+++ ++P L G GK N P A+ LT+ + + + ++ +API+++ F++ Y+
Sbjct: 338 IAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVA 397
Query: 595 VN 596
V+
Sbjct: 398 VD 399
Score = 87.4 bits (215), Expect = 7e-17
Identities = 54/176 (30%), Positives = 82/176 (46%), Gaps = 15/176 (8%)
Query: 121 GTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNG 180
GT+ GV+ C+ NIFGV+LFLR W+VG G++ +V ++T +S +
Sbjct: 40 GTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERS 99
Query: 181 VVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAE 240
+ +GG Y MIS LG + GG +GL + G AGAMYI G E + L
Sbjct: 100 SIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLL---------- 149
Query: 241 DASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAG 296
+ +R VL + + GVK++ + L+ L + +S L G
Sbjct: 150 -----GLGNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVG 200
Score = 36.2 bits (82), Expect = 0.18
Identities = 34/122 (27%), Positives = 52/122 (42%), Gaps = 30/122 (24%)
Query: 610 WRPRFRYYH-----WTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEW 664
WR +Y W +S LG L +MF+ W Y LV M +A ++Y YI
Sbjct: 582 WRRSTSFYTHMCNPW-VSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYI--------- 631
Query: 665 GDGIRGLSL-SAARYALLRLEEGPPHTKNWRPQLLV----LVRVDQDQNVVHPQLLSLTS 719
G GL L SA+ ++ R W LL+ +R Q+Q ++ P L +
Sbjct: 632 GRASPGLHLGSASNFSFFR----------WMRSLLLPSCRSLRSPQEQIILAPSLAKVDM 681
Query: 720 QL 721
++
Sbjct: 682 EM 683
>gi|33286430 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 8 isoform b [Homo
sapiens]
Length = 332
Score = 44.7 bits (104), Expect = 5e-04
Identities = 53/206 (25%), Positives = 92/206 (44%), Gaps = 25/206 (12%)
Query: 446 DLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVN-GNLVVGTLAW 504
+L D K++P ++I + VY+ + V + + L AV G ++G +AW
Sbjct: 54 ELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAW 113
Query: 505 PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLT 564
P I ST G SL + RL A +R+G +P + H K P ALL T
Sbjct: 114 IMP----ISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVK-RCTPIPALLFT 168
Query: 565 ACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWR----PRFRYYHWT 620
CI + +L+ S ++ +++ + Y+F + A Q +LR W+ PR
Sbjct: 169 -CISTLLMLVTS--DMYTLINYVGFINYLFYGVTVAGQIVLR---WKKPDIPR------- 215
Query: 621 LSFLGMSLCLALMFICSWYYALVAML 646
+ ++L ++++ W + LV L
Sbjct: 216 --PIKINLLFPIIYLLFWAFLLVFSL 239
>gi|33286428 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 8 isoform a [Homo
sapiens]
Length = 535
Score = 44.7 bits (104), Expect = 5e-04
Identities = 53/206 (25%), Positives = 92/206 (44%), Gaps = 25/206 (12%)
Query: 446 DLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVN-GNLVVGTLAW 504
+L D K++P ++I + VY+ + V + + L AV G ++G +AW
Sbjct: 257 ELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAW 316
Query: 505 PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLT 564
P I ST G SL + RL A +R+G +P + H K P ALL T
Sbjct: 317 IMP----ISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVK-RCTPIPALLFT 371
Query: 565 ACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWR----PRFRYYHWT 620
CI + +L+ S ++ +++ + Y+F + A Q +LR W+ PR
Sbjct: 372 -CISTLLMLVTS--DMYTLINYVGFINYLFYGVTVAGQIVLR---WKKPDIPR------- 418
Query: 621 LSFLGMSLCLALMFICSWYYALVAML 646
+ ++L ++++ W + LV L
Sbjct: 419 --PIKINLLFPIIYLLFWAFLLVFSL 442
>gi|195976805 hypoxia up-regulated 1 precursor [Homo sapiens]
Length = 999
Score = 42.0 bits (97), Expect = 0.003
Identities = 36/125 (28%), Positives = 58/125 (46%), Gaps = 15/125 (12%)
Query: 980 EETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAE 1039
E A S+++P E+V+L + AP S P P EP+G+ + EK DKS A+
Sbjct: 606 ESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPP-PEPKGDATPEGEKATEKENGDKSEAQ 664
Query: 1040 KNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPG 1099
K + EG+ + PE E + +R R+ E I +LV+L++P
Sbjct: 665 KPSEKAEAGPEGV----APAPEGEKKQKPARKR-----RMVEEI-----GVELVVLDLPD 710
Query: 1100 PPRNR 1104
P ++
Sbjct: 711 LPEDK 715
>gi|5453832 hypoxia up-regulated 1 precursor [Homo sapiens]
Length = 999
Score = 42.0 bits (97), Expect = 0.003
Identities = 36/125 (28%), Positives = 58/125 (46%), Gaps = 15/125 (12%)
Query: 980 EETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAE 1039
E A S+++P E+V+L + AP S P P EP+G+ + EK DKS A+
Sbjct: 606 ESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPP-PEPKGDATPEGEKATEKENGDKSEAQ 664
Query: 1040 KNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPG 1099
K + EG+ + PE E + +R R+ E I +LV+L++P
Sbjct: 665 KPSEKAEAGPEGV----APAPEGEKKQKPARKR-----RMVEEI-----GVELVVLDLPD 710
Query: 1100 PPRNR 1104
P ++
Sbjct: 711 LPEDK 715
>gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo
sapiens]
Length = 697
Score = 40.0 bits (92), Expect = 0.013
Identities = 37/157 (23%), Positives = 66/157 (42%), Gaps = 8/157 (5%)
Query: 446 DLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAW- 504
++R+ QK+IP G + ++ Y + +L +K V V W
Sbjct: 320 EVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYV----GWG 375
Query: 505 PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLT 564
P+ +V+ GS + + L S+ PR+L A++RDG++ + P A L
Sbjct: 376 PAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGLL--FRFLARVSKRQSPVAATLTA 433
Query: 565 ACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAV 601
I + + L + ++S+ LM Y V AC +
Sbjct: 434 GVISALMAFLFDLKALVDMMSIGTLMAYSLV-AACVL 469
>gi|187423910 solute carrier family 7, member 9 [Homo sapiens]
Length = 487
Score = 38.9 bits (89), Expect = 0.028
Identities = 50/216 (23%), Positives = 88/216 (40%), Gaps = 12/216 (5%)
Query: 446 DLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVN-GNLVVGTLAW 504
+LR+ +++P I+ I +A YI V + + L AV G+ V+ +
Sbjct: 244 ELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATELLQSQAVAVTFGDRVL----Y 299
Query: 505 PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANG-EPTWALLL 563
P+ W++ + FST GA + A RL+ R+G L+V + P A++
Sbjct: 300 PASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREG--HMLKVLSYISVRRLTPAPAIIF 357
Query: 564 TACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSF 623
I I I+ ++ + S + Y L V R RP +
Sbjct: 358 YGIIATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRFTRKELERPIKVPVVIPVLM 417
Query: 624 LGMSLCLALMFICS---W-YYALVAMLIAGLIYKYI 655
+S+ L L I S W Y V +++GL++ ++
Sbjct: 418 TLISVFLVLAPIISKPTWEYLYCVLFILSGLLFYFL 453
>gi|7657591 solute carrier family 7, member 9 [Homo sapiens]
Length = 487
Score = 38.9 bits (89), Expect = 0.028
Identities = 50/216 (23%), Positives = 88/216 (40%), Gaps = 12/216 (5%)
Query: 446 DLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVN-GNLVVGTLAW 504
+LR+ +++P I+ I +A YI V + + L AV G+ V+ +
Sbjct: 244 ELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATELLQSQAVAVTFGDRVL----Y 299
Query: 505 PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANG-EPTWALLL 563
P+ W++ + FST GA + A RL+ R+G L+V + P A++
Sbjct: 300 PASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREG--HMLKVLSYISVRRLTPAPAIIF 357
Query: 564 TACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSF 623
I I I+ ++ + S + Y L V R RP +
Sbjct: 358 YGIIATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRFTRKELERPIKVPVVIPVLM 417
Query: 624 LGMSLCLALMFICS---W-YYALVAMLIAGLIYKYI 655
+S+ L L I S W Y V +++GL++ ++
Sbjct: 418 TLISVFLVLAPIISKPTWEYLYCVLFILSGLLFYFL 453
>gi|56676330 HP1-BP74 [Homo sapiens]
Length = 553
Score = 38.5 bits (88), Expect = 0.037
Identities = 29/121 (23%), Positives = 52/121 (42%), Gaps = 7/121 (5%)
Query: 952 EIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPS 1011
+++ T R ++ + +L EE + + EE V + +Q + P++S S
Sbjct: 33 KVEDSTMPIRRTVNSTRETPPKSKLAEGEEEKPEPDISSEESVSTVEEQENETPPATS-S 91
Query: 1012 PGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVR 1071
E+P+GE E + ++ ++KS E K S E K P W L+ S +
Sbjct: 92 EAEQPKGEPENEEKE------ENKSSEETKKDEKDQSKEKEKKVKKTIPSWATLSASQLA 145
Query: 1072 R 1072
R
Sbjct: 146 R 146
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 37.7 bits (86), Expect = 0.063
Identities = 40/140 (28%), Positives = 62/140 (44%), Gaps = 12/140 (8%)
Query: 978 VPEETAGDSE-EKPEEEVQLIHDQSAPSCPSSSP-SPGEEPEGEGETDPEKVHLTWTKDK 1035
+P+E GD+ EKPE+ L S S S + +G+ ET P K + T K
Sbjct: 796 IPDE--GDTTPEKPEDPSALSKQSSEVSMREESDIDQNQSDDGDTETSPTK---SPTTPK 850
Query: 1036 SVAEKNKGPSPVSSEGIKDFFSMKPEWEN----LNQSNVRRMHTAVRLNEVIVKKSRDAK 1091
SV KN P+ S + E +N L+ ++ + TA NE K + +
Sbjct: 851 SVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSALSAASAFAIATA-GANEGTPNKEKYRR 909
Query: 1092 LVLLNMPGPPRNRNGDENYM 1111
+ L + PP RNGD+ ++
Sbjct: 910 MSLASAGFPPDQRNGDKEFV 929
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,568,990
Number of Sequences: 37866
Number of extensions: 2112735
Number of successful extensions: 8386
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 27
Number of HSP's successfully gapped in prelim test: 94
Number of HSP's that attempted gapping in prelim test: 8137
Number of HSP's gapped (non-prelim): 263
length of query: 1139
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1026
effective length of database: 13,968,660
effective search space: 14331845160
effective search space used: 14331845160
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.