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Search of human proteins with 197276647
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|197276647 leucine rich repeat (in FLII) interacting protein
2 isoform 3 [Homo sapiens]
(424 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|197276647 leucine rich repeat (in FLII) interacting protein 2... 812 0.0
gi|8923224 leucine rich repeat (in FLII) interacting protein 2 i... 751 0.0
gi|212276088 leucine rich repeat (in FLII) interacting protein 1... 410 e-115
gi|212276078 leucine rich repeat (in FLII) interacting protein 1... 372 e-103
gi|212276096 leucine rich repeat (in FLII) interacting protein 1... 253 2e-67
gi|5453726 leucine rich repeat (in FLII) interacting protein 2 i... 225 7e-59
gi|212276104 leucine rich repeat (in FLII) interacting protein 1... 220 2e-57
gi|212276070 leucine rich repeat (in FLII) interacting protein 1... 203 2e-52
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 77 2e-14
gi|31982906 cingulin-like 1 [Homo sapiens] 67 2e-11
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 65 1e-10
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 65 2e-10
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 64 3e-10
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 61 2e-09
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 61 2e-09
gi|156104908 myosin heavy chain 6 [Homo sapiens] 60 3e-09
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 60 3e-09
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 60 4e-09
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 60 4e-09
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 60 4e-09
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 60 4e-09
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 60 4e-09
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 60 4e-09
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 60 4e-09
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 60 4e-09
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 60 5e-09
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 60 5e-09
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 60 5e-09
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 59 6e-09
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 59 6e-09
>gi|197276647 leucine rich repeat (in FLII) interacting protein 2
isoform 3 [Homo sapiens]
Length = 424
Score = 812 bits (2098), Expect = 0.0
Identities = 424/424 (100%), Positives = 424/424 (100%)
Query: 1 MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEL 60
MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEL
Sbjct: 1 MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEL 60
Query: 61 DEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKD 120
DEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKD
Sbjct: 61 DEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKD 120
Query: 121 QIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEE 180
QIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEE
Sbjct: 121 QIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEE 180
Query: 181 QMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGD 240
QMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGD
Sbjct: 181 QMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGD 240
Query: 241 VSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQK 300
VSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQK
Sbjct: 241 VSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQK 300
Query: 301 CSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQ 360
CSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQ
Sbjct: 301 CSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQ 360
Query: 361 VLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTAL 420
VLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTAL
Sbjct: 361 VLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTAL 420
Query: 421 LAQQ 424
LAQQ
Sbjct: 421 LAQQ 424
>gi|8923224 leucine rich repeat (in FLII) interacting protein 2
isoform 2 [Homo sapiens]
Length = 400
Score = 751 bits (1939), Expect = 0.0
Identities = 400/424 (94%), Positives = 400/424 (94%), Gaps = 24/424 (5%)
Query: 1 MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEL 60
MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEL
Sbjct: 1 MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEL 60
Query: 61 DEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKD 120
DEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELR
Sbjct: 61 DEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELR------- 113
Query: 121 QIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEE 180
ESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEE
Sbjct: 114 -----------------ESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEE 156
Query: 181 QMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGD 240
QMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGD
Sbjct: 157 QMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGD 216
Query: 241 VSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQK 300
VSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQK
Sbjct: 217 VSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQK 276
Query: 301 CSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQ 360
CSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQ
Sbjct: 277 CSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQ 336
Query: 361 VLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTAL 420
VLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTAL
Sbjct: 337 VLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTAL 396
Query: 421 LAQQ 424
LAQQ
Sbjct: 397 LAQQ 400
>gi|212276088 leucine rich repeat (in FLII) interacting protein 1
isoform 2 [Homo sapiens]
Length = 394
Score = 410 bits (1055), Expect = e-115
Identities = 229/411 (55%), Positives = 298/411 (72%), Gaps = 29/411 (7%)
Query: 18 SAEDEALSNIARE-AEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYTRPS 76
S E + LS A++ AEARLAAKRAARAEAR+IRM+ELERQQKE++E+ +K + E +R
Sbjct: 9 SREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKEVEERPEKDFTEKGSRNM 68
Query: 77 SRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKEL 136
SA+ L G SSRRGSGDTS ID + S+ +E+
Sbjct: 69 PGLSAATLASLGGTSSRRGSGDTSISIDTEASI------------------------REI 104
Query: 137 KESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKEL 196
K+SL+EVEEKYKKAMVSNAQLDNEK N +YQVDTLKD++ E EEQ+AE R+ EEK+KE
Sbjct: 105 KDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEF 164
Query: 197 ERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVS---HEPVAGAITVV 253
ER+KH S+LQ + E+KE L+QR+E++EKHG+++ + NG+ S + T +
Sbjct: 165 EREKHAHSILQFQFAEVKEALKQREEMLEKHGIILNSEIATNGETSDTLNNVGYQGPTKM 224
Query: 254 SQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAG 313
++E L+S G+G LD+RL+KL E+E LL QI+KLK QLEE RQK + D +
Sbjct: 225 TKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEE-RQKIGKLDNLRSEDDV 283
Query: 314 LQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEK 373
L+NG+D+ +++QRDANRQIS+ KFKL+K+EQ+IT LEQ++ RLE QV RYK+AAENAEK
Sbjct: 284 LENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEK 343
Query: 374 VEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 424
+EDELKAEKRKLQRELR+ALDK EE+E++N HL KRLEKMKANR+ALL+QQ
Sbjct: 344 IEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQQ 394
>gi|212276078 leucine rich repeat (in FLII) interacting protein 1
isoform 1 [Homo sapiens]
Length = 640
Score = 372 bits (956), Expect = e-103
Identities = 215/435 (49%), Positives = 284/435 (65%), Gaps = 66/435 (15%)
Query: 55 RQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRD 114
R ++E+ +K + E +R SA+ L G SSRRGSGDTS ID + S+ E+++
Sbjct: 207 RASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKE 266
Query: 115 IYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDV 174
+ +LKDQIQDVEG+YMQGLKE+K+SL+EVEEKYKKAMVSNAQLDNEK N +YQVDTLKD+
Sbjct: 267 LNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDM 326
Query: 175 IEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKM----------EELKEGLRQ----- 219
+ E EEQ+AE R+ EEK+KE ER+KH S+LQ + EE+ E +RQ
Sbjct: 327 LLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQ 386
Query: 220 -------------------------------------RDEL----------IEKHGLVII 232
RD+L ++KHG+++
Sbjct: 387 ASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILN 446
Query: 233 PDGTPNGDVS---HEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRK 289
+ NG+ S + T +++E L+S G+G LD+RL+KL E+E LL QI+K
Sbjct: 447 SEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKK 506
Query: 290 LKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITT 349
LK QLEE RQK + D + L+NG+D+ +++QRDANRQIS+ KFKL+K+EQ+IT
Sbjct: 507 LKGQLEE-RQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITA 565
Query: 350 LEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKR 409
LEQ++ RLE QV RYK+AAENAEK+EDELKAEKRKLQRELR+ALDK EE+E++N HL KR
Sbjct: 566 LEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKR 625
Query: 410 LEKMKANRTALLAQQ 424
LEKMKANR+ALL+QQ
Sbjct: 626 LEKMKANRSALLSQQ 640
Score = 99.4 bits (246), Expect = 6e-21
Identities = 57/111 (51%), Positives = 73/111 (65%), Gaps = 15/111 (13%)
Query: 1 MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEL 60
MGT SGRKR P ++R +AED+AL+ IAREAEARLAAKRAARAEAR+IRM+ELERQQKE+
Sbjct: 3 MGTQGSGRKRLPNRERLTAEDDALNQIAREAEARLAAKRAARAEAREIRMKELERQQKEI 62
Query: 61 DEKSDKQY---------------AENYTRPSSRNSASATTPLSGNSSRRGS 96
+ K Y +E Y+R S RN++++ + RGS
Sbjct: 63 YQVQKKYYGLDTKWGDIEQWMEDSERYSRRSRRNTSASDEDERMSVGSRGS 113
>gi|212276096 leucine rich repeat (in FLII) interacting protein 1
isoform 3 [Homo sapiens]
Length = 808
Score = 253 bits (646), Expect = 2e-67
Identities = 164/394 (41%), Positives = 237/394 (60%), Gaps = 49/394 (12%)
Query: 18 SAEDEALSNIARE-AEARLAAKRAARAEARDIRMRELERQQKELD--------------- 61
S E + LS A++ AEARLAAKRAARAEAR+IRM+ELERQQKE D
Sbjct: 9 SREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKEEDSERYSRRSRRNTSAS 68
Query: 62 -----------------EKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLID 104
E+ +K + E +R SA+ L G SSRRGSGDTS ID
Sbjct: 69 DEDERMSVGSRGSLRVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISID 128
Query: 105 PDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNL 164
+ S+ E++++ +LKDQIQDVEG+YMQGLKE+K+SL+EVEEKYKKAMVSNAQLDNEK N
Sbjct: 129 TEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNF 188
Query: 165 IYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELI 224
+YQVDTLKD++ E EEQ+AE R+ EEK+KE ER+KH S+LQ + E+KE L+QR+E++
Sbjct: 189 MYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEML 248
Query: 225 EKHGLVIIPDGTPNGDVS---HEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKE 281
EKHG+++ + NG+ S + T +++E L+S G+G L R ++ K
Sbjct: 249 EKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLG-RASEVE-VKN 306
Query: 282 ELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLS 341
E+++ + K ++ E+++ + TV D ++ + E Q+ ++ + + L+
Sbjct: 307 EIVANVGKREILHNTEKEQ--HTEDTVKDCVDIEVFPAGENTEDQK-SSEDTAPFLGTLA 363
Query: 342 KAEQDITTLEQSISRLEGQVLRYKTAAENAEKVE 375
A T E+ + + Q+L + EN +VE
Sbjct: 364 GA-----TYEEQV---QSQILESSSLPENTVQVE 389
>gi|5453726 leucine rich repeat (in FLII) interacting protein 2
isoform 1 [Homo sapiens]
Length = 721
Score = 225 bits (573), Expect = 7e-59
Identities = 135/219 (61%), Positives = 139/219 (63%), Gaps = 74/219 (33%)
Query: 43 AEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSL 102
+E DI + +L LDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSL
Sbjct: 279 SEVDDISIPDLS----SLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSL 334
Query: 103 IDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLS--------------------- 141
IDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLS
Sbjct: 335 IDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKN 394
Query: 142 --------------EVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYR 187
E QEEQMAEFYR
Sbjct: 395 NLIYQVDTLKDVIEE-----------------------------------QEEQMAEFYR 419
Query: 188 ENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEK 226
ENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIE+
Sbjct: 420 ENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEE 458
Score = 114 bits (285), Expect = 2e-25
Identities = 59/59 (100%), Positives = 59/59 (100%)
Query: 1 MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKE 59
MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKE
Sbjct: 1 MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKE 59
>gi|212276104 leucine rich repeat (in FLII) interacting protein 1
isoform 5 [Homo sapiens]
Length = 752
Score = 220 bits (560), Expect = 2e-57
Identities = 146/362 (40%), Positives = 216/362 (59%), Gaps = 41/362 (11%)
Query: 18 SAEDEALSNIARE-AEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYTRPS 76
S E + LS A++ AEARLAAKRAARAEAR+IRM+ELERQQKE++E+ +K + E +R
Sbjct: 9 SREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKEVEERPEKDFTEKGSRNM 68
Query: 77 SRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKEL 136
SA+ L G SSRRGSGDTS ID + S+ +E+
Sbjct: 69 PGLSAATLASLGGTSSRRGSGDTSISIDTEASI------------------------REI 104
Query: 137 KESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKEL 196
K+SL+EVEEKYKKAMVSNAQLDNEK N +YQVDTLKD++ E EEQ+AE R+ EEK+KE
Sbjct: 105 KDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEF 164
Query: 197 ERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVS---HEPVAGAITVV 253
ER+KH S+LQ + E+KE L+QR+E++EKHG+++ + NG+ S + T +
Sbjct: 165 EREKHAHSILQFQFAEVKEALKQREEMLEKHGIILNSEIATNGETSDTLNNVGYQGPTKM 224
Query: 254 SQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAG 313
++E L+S G+G L R ++ K E+++ + K ++ E+++ + TV D
Sbjct: 225 TKEELNALKSTGDGTLG-RASEVE-VKNEIVANVGKREILHNTEKEQ--HTEDTVKDCVD 280
Query: 314 LQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEK 373
++ + E Q+ ++ + + L+ A T E+ + + Q+L + EN +
Sbjct: 281 IEVFPAGENTEDQK-SSEDTAPFLGTLAGA-----TYEEQV---QSQILESSSLPENTVQ 331
Query: 374 VE 375
VE
Sbjct: 332 VE 333
>gi|212276070 leucine rich repeat (in FLII) interacting protein 1
isoform 4 [Homo sapiens]
Length = 784
Score = 203 bits (517), Expect = 2e-52
Identities = 147/394 (37%), Positives = 215/394 (54%), Gaps = 73/394 (18%)
Query: 18 SAEDEALSNIARE-AEARLAAKRAARAEARDIRMRELERQQKELD--------------- 61
S E + LS A++ AEARLAAKRAARAEAR+IRM+ELERQQKE D
Sbjct: 9 SREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKEEDSERYSRRSRRNTSAS 68
Query: 62 -----------------EKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLID 104
E+ +K + E +R SA+ L G SSRRGSGDTS ID
Sbjct: 69 DEDERMSVGSRGSLRVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISID 128
Query: 105 PDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNL 164
+ S+ +E+K+SL+EVEEKYKKAMVSNAQLDNEK N
Sbjct: 129 TEASI------------------------REIKDSLAEVEEKYKKAMVSNAQLDNEKTNF 164
Query: 165 IYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELI 224
+YQVDTLKD++ E EEQ+AE R+ EEK+KE ER+KH S+LQ + E+KE L+QR+E++
Sbjct: 165 MYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEML 224
Query: 225 EKHGLVIIPDGTPNGDVS---HEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKE 281
EKHG+++ + NG+ S + T +++E L+S G+G L R ++ K
Sbjct: 225 EKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLG-RASEVE-VKN 282
Query: 282 ELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLS 341
E+++ + K ++ E+++ + TV D ++ + E Q+ ++ + + L+
Sbjct: 283 EIVANVGKREILHNTEKEQ--HTEDTVKDCVDIEVFPAGENTEDQK-SSEDTAPFLGTLA 339
Query: 342 KAEQDITTLEQSISRLEGQVLRYKTAAENAEKVE 375
A T E+ + + Q+L + EN +VE
Sbjct: 340 GA-----TYEEQV---QSQILESSSLPENTVQVE 365
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 77.4 bits (189), Expect = 2e-14
Identities = 83/420 (19%), Positives = 193/420 (45%), Gaps = 41/420 (9%)
Query: 15 DRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMR---ELERQQK-ELDEKSDKQYAE 70
+R E E LS ++ ++ ++ K + E +D++ + + +Q E EK D Q
Sbjct: 1729 ERVKMEYETLS---KKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQ--T 1783
Query: 71 NYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYM 130
N T +++ T S + S+ ++ + + D+I + Y+
Sbjct: 1784 NVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINN----YL 1839
Query: 131 QGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENE 190
Q + +LKE ++ +EE+ +K + L+NEKN L+ Q+ T ++ +E++ + N+
Sbjct: 1840 QQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQ 1899
Query: 191 EKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAI 250
+ +EL R + + + ++L+E R ++L E +G + G DV+ + +
Sbjct: 1900 QIQEELSRVTKLKETAEEEKDDLEE--RLMNQLAELNGSI----GNYCQDVTDAQIKNEL 1953
Query: 251 TVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGD 310
+ E + + E L+ ++L EK ++ S+IRK L+ + QK N +
Sbjct: 1954 --LESEMKNLKKCVSE--LEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKE 2009
Query: 311 LAGLQNGSDLQFIEMQRDA----------NRQISEYKFKLSKAEQDITTLEQSIS----- 355
L L + ++Q+D R + +F +++++D+ +++++
Sbjct: 2010 LQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEH 2069
Query: 356 --RLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIE-EMEMTNSHLAKRLEK 412
+ + ++ +K ++ + + A+ KL++EL++ + ++ +M+ + L +RLE+
Sbjct: 2070 RKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQ 2129
Score = 58.5 bits (140), Expect = 1e-08
Identities = 83/415 (20%), Positives = 171/415 (41%), Gaps = 48/415 (11%)
Query: 21 DEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNS 80
D+ LS + E + + A+ + ++ + E ERQ++ LD +S + T S
Sbjct: 747 DQLLSQVK---ELSMVTELRAQVKQLEMNLAEAERQRR-LDYESQTAHDNLLTEQIHSLS 802
Query: 81 ASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRD-IYDLKDQIQDVEGRYMQGLKELKES 139
A + + + L D SE I L+ Q+Q+ E ++G + ++
Sbjct: 803 IEAKS-----KDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHI 857
Query: 140 LSEVEEKYKKAMVSNAQLDNEKNNLIYQ---VDTLKDVIEEQEEQMAEFYRENEEKSKEL 196
S+VEE + ++ L+ + V+TL+ IEE+++Q+ E EK +L
Sbjct: 858 SSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQL 917
Query: 197 ERQKHMCSV----------LQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPV 246
+K V L + EE K+ + D + + +P G +S E +
Sbjct: 918 NEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEEL 977
Query: 247 AGAITVVSQEAAQVLESAGEGPLDVRLRKLAG---EKEELLSQIRKLKLQLEEERQKCSR 303
++ +E Q R RKL ++ELL ++ +L+ +L + + +
Sbjct: 978 QHEFDLLKKENEQ------------RKRKLQAALINRKELLQRVSRLEEELANLKDESKK 1025
Query: 304 NDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLR 363
L+ + G E++ D + K SK ++ L+Q+IS E ++
Sbjct: 1026 EI----PLSETERG------EVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQH 1075
Query: 364 YKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRT 418
+ E E++ +A +++ + L+ ++I+ ++ S ++K+ + T
Sbjct: 1076 IRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNT 1130
Score = 55.8 bits (133), Expect = 7e-08
Identities = 95/437 (21%), Positives = 183/437 (41%), Gaps = 63/437 (14%)
Query: 13 VKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENY 72
+K S ++ L +I ++ E +LAA+ +A ++++ + ++ + D AE
Sbjct: 1062 LKQTISEKEVELQHIRKDLEEKLAAEEQFQA-----LVKQMNQTLQDKTNQIDLLQAE-- 1114
Query: 73 TRPSSRNSASATTPLSGNSSRRGSGDTSSL------IDPDTSLSELRDIYDLKDQIQDVE 126
S N A ++ N+ GD+ +L I P + S +L+++I +E
Sbjct: 1115 ---ISENQAIIQKLITSNTDA-SDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALE 1170
Query: 127 GRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFY 186
Q K+L+E+L+ +KA++ AQ ++ +L ++ KD +EQ E
Sbjct: 1171 KEKEQLQKKLQEALTS-----RKAILKKAQ--EKERHLREELKQQKDDYNRLQEQFDEQS 1223
Query: 187 RENEEKSKELER-----------------QKHMCSVLQHKMEELKEGLRQRDELIEKHGL 229
+ENE +L + Q+ CS E L + Q H
Sbjct: 1224 KENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQH------HTQ 1277
Query: 230 VIIPDGTPNGDVSHEPVAGAI---TVVSQEAAQVLESAGE--------GPLDVRLRKLAG 278
++ SH A A+ T V+Q AQ+ E E L K +
Sbjct: 1278 PVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSE 1337
Query: 279 EKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQF--IEMQRDANRQISEY 336
E +L QI K L++E + + L S LQ +E R+ ++ E
Sbjct: 1338 EVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDEL 1397
Query: 337 KFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKI 396
+ +SK E+D++ L +S E + + +T E E+ ED +KA +L+ + + ++I
Sbjct: 1398 QKLISKKEEDVSYLSGQLSEKEAALTKIQT--EIIEQ-EDLIKALHTQLEMQAKEHDERI 1454
Query: 397 EEMEMTNSHLAKRLEKM 413
+++++ + ++ E++
Sbjct: 1455 KQLQVELCEMKQKPEEI 1471
Score = 52.0 bits (123), Expect = 1e-06
Identities = 81/452 (17%), Positives = 179/452 (39%), Gaps = 52/452 (11%)
Query: 15 DRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMR------ELERQQKELDEKSDKQY 68
+ E A I R+ +A L +++ A E + ++ +ER K L + +
Sbjct: 1469 EEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVS 1528
Query: 69 AENYTRPS----------SRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDL 118
A+N + + R+ S ++ S SL L+E D L
Sbjct: 1529 AQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTE--DKEKL 1586
Query: 119 KDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQ 178
+I+ ++ + E +E E++++Y+ + S + NE + + V+ ++ +E
Sbjct: 1587 VKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQEL 1646
Query: 179 EEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPN 238
++ +E K+L+ + ++ KM + + +Q+ +E+ + + P
Sbjct: 1647 YGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPA 1706
Query: 239 GDVSHEPVAGAITVVSQEAAQVLE----SAGEGPLDVRLRKLAGEKEELLSQIRKLKLQL 294
GD + E + T++S A+ E L + + L EK+ L +++ LK Q+
Sbjct: 1707 GDTAKECME---TLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQI 1763
Query: 295 E--------------EERQKCSRNDGTVGDLAGLQNGSDL---------QFIEMQRDANR 331
E + Q +GT + L + + + AN
Sbjct: 1764 EGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANP 1823
Query: 332 QISE---YKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRE 388
+S+ +++ Q I L++ I+ LE + + K ++ E ++ L ++ E
Sbjct: 1824 AVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGE 1883
Query: 389 LRTALDKIEEMEMTNSHLAKRLEKM-KANRTA 419
L+ +++ +M + N + + L ++ K TA
Sbjct: 1884 LKMLQEEVTKMNLLNQQIQEELSRVTKLKETA 1915
Score = 50.8 bits (120), Expect = 2e-06
Identities = 80/416 (19%), Positives = 175/416 (42%), Gaps = 57/416 (13%)
Query: 44 EARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLI 103
E + M+ L++ EL+E+ +Q + T+ S + G G+
Sbjct: 1952 ELLESEMKNLKKCVSELEEEK-QQLVKEKTKVESEIRKEYLEKIQGAQKEPGN------- 2003
Query: 104 DPDTSLSELRDIYDLKDQIQDVEG------RYMQGLKELKESLSEVEEKYKKAMVSNAQL 157
+ EL+++ LK++ Q+V+ RY + + L+ ++ +E + S L
Sbjct: 2004 --KSHAKELQEL--LKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTE---SQKDL 2056
Query: 158 DNEKNNLIYQVD----------TLKDVIEEQEEQMAEFYRENEEKSKELERQKHMC-SVL 206
+ K NL V+ + K ++++ + + A +N + KEL+ K S +
Sbjct: 2057 EITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQM 2116
Query: 207 QHKMEELKEGLRQRDE--LIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESA 264
+ K E+L+ L Q +E L EK + D V E G I V + + ++
Sbjct: 2117 KQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQL 2176
Query: 265 GEGPLDVRLRKLAG----------EKEELLSQIRKLK------LQLEEERQKCSRNDGTV 308
E LD + +LA +++ ++ + +K + +Q +EE + ++ +V
Sbjct: 2177 QEN-LDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSV 2235
Query: 309 GDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAA 368
L + E++ + +R + + SKA+ ++ ++ L+G+ +
Sbjct: 2236 --LKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQL 2293
Query: 369 ENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 424
E + + E KL+ EL++ D++ ++ S+ ++ ++ K N ++ QQ
Sbjct: 2294 EETRHLYHSSQNELAKLESELKSLKDQLTDL----SNSLEKCKEQKGNLEGIIRQQ 2345
Score = 49.7 bits (117), Expect = 5e-06
Identities = 66/325 (20%), Positives = 136/325 (41%), Gaps = 39/325 (12%)
Query: 122 IQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQ 181
I ++ ++ + +KEL+ LS+ EE+ N + ++ N L+ + T+K +Q+ Q
Sbjct: 2399 IAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQ 2458
Query: 182 MAEFYRENEEKSKELER---------QKHMCSVLQHKMEELKEGLRQRDELIEK-HGLVI 231
+ F + + +R ++H+ S++ K + ++E + ++L E+ GL
Sbjct: 2459 LDSFVKSMSSLQNDRDRIVGDYQQLEERHL-SIILEKDQLIQEAAAENNKLKEEIRGLRS 2517
Query: 232 IPDGTPNGDVS--------HEPVAGAITVVSQEAAQVLESAGEGPLDV-----RLRKLAG 278
D + + E + IT+ + Q+LE + ++ +L +
Sbjct: 2518 HMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLK 2577
Query: 279 EKEELLSQIRKLKLQLEEERQKCSRN--------DGTVGDLAGLQNGSDLQFIEMQ-RDA 329
E EE +R+ L+EE+Q S+ + LQ L Q +
Sbjct: 2578 ESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVK 2637
Query: 330 NRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQREL 389
++ S +++ I LE+ + V K AA+ ++ED+LK E + L +
Sbjct: 2638 EEEVHRLSALFSSSQKRIAELEEEL------VCVQKEAAKKVGEIEDKLKKELKHLHHDA 2691
Query: 390 RTALDKIEEMEMTNSHLAKRLEKMK 414
++ E E + LA+ L +M+
Sbjct: 2692 GIMRNETETAEERVAELARDLVEME 2716
Score = 48.9 bits (115), Expect = 9e-06
Identities = 72/317 (22%), Positives = 136/317 (42%), Gaps = 34/317 (10%)
Query: 109 LSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQV 168
L LR++ D++Q + + + + L LSE E A L + +I Q
Sbjct: 1384 LEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKE----------AALTKIQTEIIEQE 1433
Query: 169 DTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEK-- 226
D +K + + E Q +E++E+ K+L Q +C + Q K EE+ E R + ++ K
Sbjct: 1434 DLIKALHTQLEMQA----KEHDERIKQL--QVELCEMKQ-KPEEIGEESRAKQQIQRKLQ 1486
Query: 227 HGLVIIPDGTPNGDVSHEPVA---GAITVVSQEAAQVLE--SAGEGPLDVRLRKLAGEKE 281
L+ + E ++ G I +++ A V SA D L +LA +E
Sbjct: 1487 AALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQE 1546
Query: 282 ELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQI---SEYKF 338
E I ++ L E + S + L GL + E++ + +I +E++
Sbjct: 1547 ERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQE 1606
Query: 339 KLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDEL-------KAEKRKLQRELRT 391
K + +++ L QS + + R + E + + EL +A K++ +++L+
Sbjct: 1607 KHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQE 1666
Query: 392 ALDKIEEMEMTNSHLAK 408
A ++EEM+ AK
Sbjct: 1667 AEQEMEEMKEKMRKFAK 1683
Score = 47.4 bits (111), Expect = 3e-05
Identities = 88/435 (20%), Positives = 169/435 (38%), Gaps = 57/435 (13%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKS 64
AS + + + + +++ + ++ E + A + D ++ELE + +E++
Sbjct: 2365 ASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEEN 2424
Query: 65 DKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQD 124
EN N T + + S + +SL RD + Q
Sbjct: 2425 IVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRD--RIVGDYQQ 2482
Query: 125 VEGRYMQGLKE--------------LKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDT 170
+E R++ + E LKE + + NA+LD E LI +
Sbjct: 2483 LEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAE---LIQYRED 2539
Query: 171 LKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLV 230
L VI ++ Q + +++KELE + + EE E LR+ +++
Sbjct: 2540 LNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEE--- 2596
Query: 231 IIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEE------LL 284
D+S E + +SQ QV EG L + +L ++EE L
Sbjct: 2597 -------KQDLSKE-IESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALF 2648
Query: 285 SQIRKLKLQLEEE----RQKCSRNDGTVGD-----LAGLQNGSDLQFIEMQRDANRQISE 335
S +K +LEEE +++ ++ G + D L L + + + E + A +++E
Sbjct: 2649 SSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETET-AEERVAE 2707
Query: 336 YKFKLSKAEQDITTLEQSISRLEGQVLRY-------KTAAENAEKVEDELKAEKRKLQRE 388
L + EQ + + + L Q+ + + + ++A + DEL KRK
Sbjct: 2708 LARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDEL---KRKYDAS 2764
Query: 389 LRTALDKIEEMEMTN 403
L+ L +++E + N
Sbjct: 2765 LK-ELAQLKEQGLLN 2778
Score = 47.0 bits (110), Expect = 3e-05
Identities = 79/423 (18%), Positives = 167/423 (39%), Gaps = 40/423 (9%)
Query: 13 VKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDK------ 66
+K+ +++ L N RE +A L+ + + + LE+ ++L K ++
Sbjct: 2765 LKELAQLKEQGLLN--RERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSS 2822
Query: 67 QYAENYTRPSSRNSASATTPLSGNS--------SRRGSGDTSSLIDPDTSLSELRDIYDL 118
Q ++Y + S + A A+ + + G S P TS +E++ +
Sbjct: 2823 QLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKA 2882
Query: 119 KDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQL----DNEKNNLIYQVDTLKDV 174
+Q+ R ++ LK L++ ++ ++ + AQL D K I Q + ++
Sbjct: 2883 MSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQEN 2942
Query: 175 IEEQEE-----QMAEFYRENEEKSKE-----LERQKHMCSVLQHKMEELKEGLRQRDELI 224
+ Q E + +E + KE + + S LQ+ + EL+ Q L
Sbjct: 2943 LSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLK 3002
Query: 225 EKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELL 284
++ P+ + + D S V + +Q + E + ++R+++L +LL
Sbjct: 3003 VQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQK---ELRIQQLNSNFSQLL 3059
Query: 285 SQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQR-----DANRQISEYKFK 339
+ L +QL + Q N GDL + Q E+Q D + K
Sbjct: 3060 EEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNG 3119
Query: 340 LSKAE--QDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIE 397
+ + +++ +QS S + Q+ + K+ +E + ++ + L A ++I
Sbjct: 3120 VHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIR 3179
Query: 398 EME 400
+E
Sbjct: 3180 RLE 3182
Score = 45.8 bits (107), Expect = 7e-05
Identities = 71/336 (21%), Positives = 130/336 (38%), Gaps = 45/336 (13%)
Query: 115 IYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKK----AMVSNAQLDNEKNNLIYQVDT 170
+ +LKD I+ + + Q + L+E + K KK A L+ + Q T
Sbjct: 61 VVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGT 120
Query: 171 LKDVIEEQEEQMAEFYRENEEKSKELERQKH-------MCSVLQHKM------------E 211
+ + EEQ+++ + + E+ E+E+ KH + S LQ ++
Sbjct: 121 VLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSST 180
Query: 212 ELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLD- 270
E++E + + +L EK + T +S A V +E E+ D
Sbjct: 181 EMEEFVMMKQQLQEKEEFI----STLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDE 236
Query: 271 -VRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDA 329
++L A + E+ ++R L+ +LEE + L G DL E+
Sbjct: 237 LLQLVTQADVETEMQQKLRVLQRKLEEHEE----------SLVGRAQVVDLLQQELTAAE 286
Query: 330 NR-QISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRE 388
R QI + + +AE + R E ++L K E AE+ K LQ E
Sbjct: 287 QRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAER-----KLSFHNLQEE 341
Query: 389 LRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 424
+ L++ E+ + L R ++ A + ++
Sbjct: 342 MHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEK 377
Score = 44.3 bits (103), Expect = 2e-04
Identities = 53/265 (20%), Positives = 110/265 (41%), Gaps = 23/265 (8%)
Query: 131 QGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENE 190
Q EL+ S +E+K+K M ++ + D +++Q ++ + +NE
Sbjct: 354 QAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQ--DKNE 411
Query: 191 EKSKELERQKHMCSVLQHKMEELKEGLRQRD-ELIEKHGLVIIPDGTPNGD--VSHEPVA 247
+ + + + + LQ K +E+ + L + + E PD G V+ E +A
Sbjct: 412 QAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIA 471
Query: 248 G----AITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSR 303
+ + +++ A +L S + L +L E E+L SQI L+ Q
Sbjct: 472 SLQKRVVELENEKGALLLSS-------IELEELKAENEKLSSQITLLEAQNRTGEADREV 524
Query: 304 NDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLR 363
++ ++ D+A ++ S ++ + + E F E + LE ++ E L+
Sbjct: 525 SEISIVDIANKRSSS-------AEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLK 577
Query: 364 YKTAAENAEKVEDELKAEKRKLQRE 388
+ + AE+ + E+ +K Q E
Sbjct: 578 LQLQGKRAEEADHEVLDQKEMKQME 602
Score = 43.5 bits (101), Expect = 4e-04
Identities = 83/420 (19%), Positives = 167/420 (39%), Gaps = 57/420 (13%)
Query: 13 VKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDE------KSDK 66
VK + +DE L +AE + ++ E D RE ++ + E K DK
Sbjct: 2112 VKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDK 2171
Query: 67 QYAENYTRPSSRNSASATTPLSGNSSRRGS--GDTSSLIDPDTSLSELRDIYDLKDQIQD 124
+ + N S T L+ + S D +ID D IQ
Sbjct: 2172 EVQQ-----LQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWER-----KFSDAIQS 2221
Query: 125 VEGRYMQGLKE-----LKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQE 179
E LKE LK+ L ++ ++ ++ ++L+++K + T ++ Q+
Sbjct: 2222 KEEEIR--LKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQT---EVQLQQ 2276
Query: 180 EQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQ-RDELIEKHGLVIIPDGTPN 238
+ EN+E +LE +H+ Q+++ +L+ L+ +D+L + +
Sbjct: 2277 KVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSL-------- 2328
Query: 239 GDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEEL-LSQIRKLKLQLEEE 297
+ E ++ Q+ A D++ K + E+ E L R+L +L EE
Sbjct: 2329 -EKCKEQKGNLEGIIRQQEA-----------DIQNSKFSYEQLETDLQASRELTSRLHEE 2376
Query: 298 RQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRL 357
+ + L+G + + E+++ +++I E + LS+ E++ LE+ +
Sbjct: 2377 INM--KEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKA 2434
Query: 358 EGQVLRYKTAAENAEKVEDELKAEKR---KLQRELRTALDKI--EEMEMTNSHLAKRLEK 412
+ + + +K + KA+ K L+ D+I + ++ HL+ LEK
Sbjct: 2435 VDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEK 2494
Score = 42.4 bits (98), Expect = 8e-04
Identities = 98/498 (19%), Positives = 200/498 (40%), Gaps = 96/498 (19%)
Query: 10 RTPVKDRFSAE-DEALSNIARE-AEARLAAKRAARAEARDI-RMRELERQQKELDEKSDK 66
R P+ E D +N +E + RLA E +DI R ++++ QQK+ + ++
Sbjct: 27 RAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEER 86
Query: 67 QYAENYTRPSSRNSASATTPLSGN-SSRRGSGDTSSLIDPD----------TSLSELRDI 115
+ A+N + ++ + T L+ + G T +P +S E +I
Sbjct: 87 KAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEI 146
Query: 116 YDLKDQIQDVE---------------------GRYMQGLKELKESLSEVEE--KYKKAMV 152
+K ++Q+ E M+ +K+ L E EE +A +
Sbjct: 147 EKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQL 206
Query: 153 SNAQLDNEKNNLIYQVDT-LKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKME 211
S Q + ++ + D + + E+++ + + + E E Q+ + VLQ K+E
Sbjct: 207 SQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQAD---VETEMQQKL-RVLQRKLE 262
Query: 212 ELKEGLRQRDELIE---------KHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLE 262
E +E L R ++++ + I+ + H + + +E+ +LE
Sbjct: 263 EHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLE 322
Query: 263 SAGEGPLDVRLRKLA-----GEKEELLSQIR---KLKLQLE------EERQKCSRNDGTV 308
L+V RKL+ E LL Q + + +LE E++ K + T
Sbjct: 323 KM---ELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTS 379
Query: 309 GDLAGLQNGSDLQFI---------EMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEG 359
L+ + G +LQ ++ +D N Q + + + E + + IS+
Sbjct: 380 HILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLN 439
Query: 360 Q--VLRYKTAA---------ENAEKVEDE--LKAEKRKLQRE-----LRTALDKIEEMEM 401
+ + +++TA+ E + V +E +KR ++ E L + ++EE++
Sbjct: 440 RLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKA 499
Query: 402 TNSHLAKRLEKMKA-NRT 418
N L+ ++ ++A NRT
Sbjct: 500 ENEKLSSQITLLEAQNRT 517
Score = 36.2 bits (82), Expect = 0.058
Identities = 86/430 (20%), Positives = 175/430 (40%), Gaps = 51/430 (11%)
Query: 34 RLAAKRAARAEARDIRMRELERQQKE-LDEKSDKQYAENYTR-----PSSRNSASATTPL 87
+L KRA A+ + +E+++ + E + K + E+ + P+ +S A
Sbjct: 579 QLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKE 638
Query: 88 SGNSSRRG-SGDTSSLIDPDTSLSELRDIYDLK-DQIQDVEGRYMQGLKELKESLSEVEE 145
++ + + + SL D L + D + D+ + L+ LK + E+E
Sbjct: 639 QASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELEL 698
Query: 146 KYKKAM-VSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCS 204
+ KA + LD + + +++ + + + F +EE+ + L + K +
Sbjct: 699 NFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSM 758
Query: 205 VLQHKME------ELKEGLRQR----------DELIEK--HGLVIIPDGTPNGDVSHEPV 246
V + + + L E RQR D L+ + H L I + DV E +
Sbjct: 759 VTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSI---EAKSKDVKIEVL 815
Query: 247 AGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRN-- 304
+ V + ++ +S L +L+ E E ++R + ++EE Q S+
Sbjct: 816 QNELDDVQLQFSE--QSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKEL 873
Query: 305 DGTVGDLAGLQNGSDLQFIEMQ-RDANRQISEYKF----KLSKAEQDITTLEQSISRLEG 359
+ T D L+ D++ ++ + ++Q++E F K+ + ++ +L I L+
Sbjct: 874 EITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKE 933
Query: 360 QVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKI--------EEMEMTNSHLAKRLE 411
Q L + AE A+K + E E ++ L+ D++ EE++ L K E
Sbjct: 934 Q-LNLLSRAEEAKKEQVE---EDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENE 989
Query: 412 KMKANRTALL 421
+ K A L
Sbjct: 990 QRKRKLQAAL 999
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 67.4 bits (163), Expect = 2e-11
Identities = 102/448 (22%), Positives = 188/448 (41%), Gaps = 76/448 (16%)
Query: 20 EDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRN 79
E+E L + E E R+A + + + + E +K E + A + R +
Sbjct: 830 ENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKE 889
Query: 80 SASATTPLSGNSSRRGSGDTSSLIDPDTSLSE-LRDIYDLKDQIQDVEGRYMQGLKELKE 138
+ SA L N G+ S LSE L++ + K+Q++ R ++ +
Sbjct: 890 AVSARRALE-NELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLR----RLKNEMENERW 944
Query: 139 SLSEVEEKYKKAMVSNAQLDNEKN-NLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELE 197
L + EK +K M + L Q+D K E+ ++AE R+ +EK+ E E
Sbjct: 945 HLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYK---EKNRRELAEMQRQLKEKTLEAE 1001
Query: 198 RQKHMCSVLQHKM----EELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVV 253
+ + +Q +M EEL++ R +DE + K L+ D+ +E A + +
Sbjct: 1002 KSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLL----EQTLKDLEYE--LEAKSHL 1055
Query: 254 SQEAAQVLESAGE--GPLDVRLRKLAGEKEELLSQIRKLKLQLEEER-----QKCSRNDG 306
+ +++++ + L++ L + + L +I + + Q+E+ R ++ +R D
Sbjct: 1056 KDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDL 1115
Query: 307 TVGDLAGLQNGSDLQF---------------IEMQRDANRQISEYKFKLSKAEQDITTLE 351
++ + DL+ + +Q +A +I+E + +L E+D L+
Sbjct: 1116 ECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEA--RIAELEDRLESEERDRANLQ 1173
Query: 352 QSISRLEGQV----------------------LRYKTAAENAEKVEDE---LKAEKRKLQ 386
S RLE +V LR K E+ E+E L++ K+KLQ
Sbjct: 1174 LSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQ 1233
Query: 387 RELRTALDKIEEMEMTNSHLAKRLEKMK 414
REL E+M+M N HL +L MK
Sbjct: 1234 RELE------EQMDM-NEHLQGQLNSMK 1254
Score = 50.4 bits (119), Expect = 3e-06
Identities = 86/435 (19%), Positives = 176/435 (40%), Gaps = 86/435 (19%)
Query: 40 AARAEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDT 99
A+ +A ++ + ++ +E++ KQ NY + S ++ AT
Sbjct: 530 ASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATK-------------- 575
Query: 100 SSLIDPDTSLSELRDIYDLKDQIQDVEGRYM---QGLKELKESLSEVEEKYKKAMVSNAQ 156
R + + ++IQ ++ R QG + S SEV++ ++ +
Sbjct: 576 -------------RKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIE 622
Query: 157 LDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEG 216
+ + L +V +++ EE+E A + ++++E S LQ ++EE +
Sbjct: 623 VAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEEN----STLQQRLEESEGE 678
Query: 217 LRQRDELI-------EKHGLVI---------IPDGTPNGDVSHEPVAGAITVVSQEAAQV 260
LR+ E + E+H I + D + S + GA+ +A Q
Sbjct: 679 LRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQD 738
Query: 261 LES---AGEGPLDVRLRKLAGE--------KEELLS---QIRKLKLQLEEERQK------ 300
L+ A E D+ LRK E KEE+ S ++ KLK Q + E Q
Sbjct: 739 LQDLLIAKEEQEDL-LRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVE 797
Query: 301 ---------CSRNDGTVGDLAGLQNGSDLQFIEMQR------DANRQISEYKFKLSKAEQ 345
SR++ + D AG + L E ++ + R++++ + ++ +
Sbjct: 798 EATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKG 857
Query: 346 DITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSH 405
D ++++ + EG++ + + A +A K E E + +R L+ EL A + +
Sbjct: 858 DEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQ 917
Query: 406 LAKRLEKMKANRTAL 420
L+++L++ + L
Sbjct: 918 LSEKLKEESEQKEQL 932
Score = 47.4 bits (111), Expect = 3e-05
Identities = 64/296 (21%), Positives = 117/296 (39%), Gaps = 62/296 (20%)
Query: 13 VKDRFSAEDEALSN------------IAREAEARLAAKRAARAEARDIRMRELERQQKEL 60
++D A+DEAL+ EA++ L R+ + + ++ +LE + +E
Sbjct: 1021 LRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEE 1080
Query: 61 DEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKD 120
SD +E +R + L ++R+ ++ D +S R DLK
Sbjct: 1081 RNNSDL-LSERISRSREQMEQLRNELLQERAARQD-------LECD-KISLERQNKDLKS 1131
Query: 121 QIQDVEGRYMQG-----------LKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVD 169
+I +EG Y + EL++ L E +SN +L+ + L+ QVD
Sbjct: 1132 RIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVD 1191
Query: 170 ------------------TLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKME 211
+K +EE EE++ ++ +ELE Q M LQ ++
Sbjct: 1192 DEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLN 1251
Query: 212 ELKEGLRQR-------DELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQV 260
+K+ LR + D++ + L T G + PV+ + S A+Q+
Sbjct: 1252 SMKKDLRLKKLPSKVLDDMDDDDDL-----STDGGSLYEAPVSYTFSKDSTVASQI 1302
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 65.1 bits (157), Expect = 1e-10
Identities = 67/311 (21%), Positives = 133/311 (42%), Gaps = 36/311 (11%)
Query: 118 LKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDN---EKNNLIYQVDTLKDV 174
L+DQ+ + G+ +E++ SLSE+ + + +L EK +++ Q+ K
Sbjct: 1253 LEDQLSEARGKN----EEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQA 1308
Query: 175 IEEQEEQMAEFYRENEEKSKE-----LERQKHMCSVLQHKMEELKEGLRQRDELIEKHGL 229
+Q E++ E E K+K L+ +H C +L+ + EE +EG + + K
Sbjct: 1309 FTQQTEELKR-QLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSK--- 1364
Query: 230 VIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRK 289
++ VA T +A Q E E +L + + EE + +
Sbjct: 1365 ------------ANSEVAQWRTKYETDAIQRTEELEEAKK--KLAQRLQDSEEQVEAVNA 1410
Query: 290 LKLQLEEERQKCSRNDGTVGDL---AGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQD 346
LE+ +Q R G V DL N + QR+ ++ ++E+K K +++ +
Sbjct: 1411 KCASLEKTKQ---RLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAE 1467
Query: 347 ITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHL 406
+ + L ++ + K A E A + +K E + L++E+ ++I E T L
Sbjct: 1468 LEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHEL 1527
Query: 407 AKRLEKMKANR 417
K ++++ +
Sbjct: 1528 EKSRKQIELEK 1538
Score = 60.5 bits (145), Expect = 3e-09
Identities = 64/268 (23%), Positives = 123/268 (45%), Gaps = 26/268 (9%)
Query: 149 KAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSV-LQ 207
K ++ +A+ + E + + KD + + E + E EEK L ++K+ + +Q
Sbjct: 838 KPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKEL----EEKLVTLVQEKNDLQLQVQ 893
Query: 208 HKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEG 267
+ E L + + D+LI+ + + I V++ A E E
Sbjct: 894 AESENLLDAEERCDQLIK----------------AKFQLEAKIKEVTERAEDEEEINAE- 936
Query: 268 PLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQR 327
L + RKL E EL I L+L L + ++ + V +L +G D ++ R
Sbjct: 937 -LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTR 995
Query: 328 DANRQISEYKFKLS--KAEQD-ITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRK 384
+ ++ L +AE+D + +L ++ S+LE QV +++ E +K+ +L+ KRK
Sbjct: 996 EKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRK 1055
Query: 385 LQRELRTALDKIEEMEMTNSHLAKRLEK 412
L+ +L+ A + I ++E L +RL+K
Sbjct: 1056 LEGDLKLAQESILDLENDKQQLDERLKK 1083
Score = 56.2 bits (134), Expect = 5e-08
Identities = 92/472 (19%), Positives = 204/472 (43%), Gaps = 85/472 (18%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAAR--AEARDIRMRELERQQKELDE 62
A+ K + + S DE ++ + RE +A A + A +A + ++ L + + +L++
Sbjct: 971 ATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQ 1030
Query: 63 KSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTS----SLIDPDTSLSELRDIYDL 118
+ + S L N R+ GD S++D + +L +
Sbjct: 1031 QVED------LESSLEQEKKLRVDLERNK-RKLEGDLKLAQESILDLENDKQQLDERLKK 1083
Query: 119 KD--------QIQDVEG---RYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQ 167
KD +++D + ++ + +KEL+ + E+EE+ + + A+ + ++++ +
Sbjct: 1084 KDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARE 1143
Query: 168 VDTLKDVIEE--------------QEEQMAEFYRENEEKSKELE------RQKHMCSVLQ 207
++ L + +EE +E + + R+ EE + + E R+KH SV +
Sbjct: 1144 LEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAE 1203
Query: 208 HKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEG 267
+ E + L++ + +EK + + ++ ++ VS+ A + +
Sbjct: 1204 --LGEQIDNLQRVKQKLEKE--------KSEFKLEIDDLSSSMESVSKSKANLEKIC--R 1251
Query: 268 PLDVRLRKLAGEKEEL---LSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIE 324
L+ +L + G+ EE+ LS++ K +L+ E + SR + + S F +
Sbjct: 1252 TLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQ 1311
Query: 325 MQRDANRQISE---------YKFKLSKAEQDI------------TTLEQSISRLEGQVLR 363
+ RQ+ E + + S+ + D+ L++++S+ +V +
Sbjct: 1312 QTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQ 1371
Query: 364 YKTAAE-NAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMK 414
++T E +A + +EL+ K+KL + L+ D E++E N+ A LEK K
Sbjct: 1372 WRTKYETDAIQRTEELEEAKKKLAQRLQ---DSEEQVEAVNAKCAS-LEKTK 1419
Score = 54.3 bits (129), Expect = 2e-07
Identities = 83/425 (19%), Positives = 173/425 (40%), Gaps = 40/425 (9%)
Query: 11 TPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAE 70
T K R E LS E E+ + ++ + +A + EL+RQ L+E++ + A
Sbjct: 1275 TTQKSRLQTEAGELSRQLEEKES-IVSQLSRSKQAFTQQTEELKRQ---LEEENKAKNAL 1330
Query: 71 NYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYM 130
+ SSR+ + +L ++ +++ R Y+ D IQ E
Sbjct: 1331 AHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYET-DAIQRTE-ELE 1388
Query: 131 QGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQ------------ 178
+ K+L + L + EE+ + A L+ K L +V+ L +E
Sbjct: 1389 EAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQR 1448
Query: 179 --EEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELK----------EGLRQRDELIEK 226
++ +AE+ + EE ELE L ++ +LK E +++ ++ +E+
Sbjct: 1449 NFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQ 1508
Query: 227 HGLVIIPDGTPNGDVSHEPVAGA---------ITVVSQEAAQVLESAGEGPLDVRLRKLA 277
+ NG HE I + +EA LE L ++L +L
Sbjct: 1509 EIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQL-ELT 1567
Query: 278 GEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYK 337
K E+ +I + ++E+ ++ R T+ + S + I +++ ++E +
Sbjct: 1568 QVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIE 1627
Query: 338 FKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIE 397
+LS A + + + ++GQ+ + ++A + +++LK + ++R ++E
Sbjct: 1628 IQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVE 1687
Query: 398 EMEMT 402
E+ T
Sbjct: 1688 ELRAT 1692
Score = 44.3 bits (103), Expect = 2e-04
Identities = 72/308 (23%), Positives = 131/308 (42%), Gaps = 60/308 (19%)
Query: 112 LRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTL 171
L D + DQ+ + + +KE+ E + EE NA+L +K L + L
Sbjct: 899 LLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEE-------INAELTAKKRKLEDECSEL 951
Query: 172 KDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVI 231
K I++ E +A ++E++KH ++K++ L E L DE I K
Sbjct: 952 KKDIDDLELTLA-----------KVEKEKH---ATENKVKNLTEELSGLDETIAK----- 992
Query: 232 IPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGE--GPLDVRLRKLAGEKEEL---LSQ 286
++ E A+ Q+A L++ + L+ KL + E+L L Q
Sbjct: 993 ---------LTRE--KKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQ 1041
Query: 287 IRKLKLQLEEERQKCSRNDGTVGDLAGLQNG-SDLQFIEMQRDANRQISEYKF-KLSKAE 344
+KL++ LE ++K GDL Q DL+ + Q D + ++++ +L
Sbjct: 1042 EKKLRVDLERNKRKLE------GDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKV 1095
Query: 345 QDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNS 404
+D TL + + K E++E+E++AE+ + + D E+E
Sbjct: 1096 EDEQTLGLQFQK------KIKELQARIEELEEEIEAERATRAKTEKQRSDYARELE---- 1145
Query: 405 HLAKRLEK 412
L++RLE+
Sbjct: 1146 ELSERLEE 1153
Score = 35.4 bits (80), Expect = 0.099
Identities = 70/334 (20%), Positives = 139/334 (41%), Gaps = 41/334 (12%)
Query: 107 TSLSELRDIYD-LKDQIQDVEGRYM---QGLKELKESLSEVEEKYKKAMVSNAQLDNEKN 162
T L +L++ Y+ DQ++ V+ Q + +L E ++E + + S Q++ EK
Sbjct: 1480 TELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKA 1539
Query: 163 NLIYQVDTLKDVIEEQEEQM-----------AEFYRENEEKSKELERQKHMCSVLQHKME 211
++ ++ + +E +E ++ +E R+ EK +E+E+ K M+
Sbjct: 1540 DIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQ 1599
Query: 212 E-LKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLD 270
L +R R+E I + +SH A T+ + Q + LD
Sbjct: 1600 SALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLD 1659
Query: 271 VRLRKLAGEKEELLSQIRK---LKLQLEEERQKCSRNDGT--VGDLAGLQNGSDLQFIEM 325
LR KE+L R+ L+ ++EE R + + + + L + +Q +
Sbjct: 1660 DALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHT 1719
Query: 326 QRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEK------VEDELK 379
Q N + K KL E + +L+ +V A NAE+ + +
Sbjct: 1720 Q---NTSLIHTKKKL----------ETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMM 1766
Query: 380 AEKRKLQRELRTALDKIEE-MEMTNSHLAKRLEK 412
AE+ K +++ L+++++ +E T L RL++
Sbjct: 1767 AEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE 1800
Score = 33.9 bits (76), Expect = 0.29
Identities = 31/145 (21%), Positives = 61/145 (42%), Gaps = 14/145 (9%)
Query: 279 EKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKF 338
+ EE Q+ K K QLE + ++ V + A + + + +R + SE K
Sbjct: 901 DAEERCDQLIKAKFQLEAKIKE-------VTERAEDEEEINAELTAKKRKLEDECSELKK 953
Query: 339 KLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTAL----- 393
+ E + +E+ E +V ++ +L EK+ LQ + AL
Sbjct: 954 DIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQA 1013
Query: 394 --DKIEEMEMTNSHLAKRLEKMKAN 416
DK+ + T S L +++E ++++
Sbjct: 1014 EEDKVNSLNKTKSKLEQQVEDLESS 1038
Score = 32.7 bits (73), Expect = 0.64
Identities = 23/104 (22%), Positives = 50/104 (48%), Gaps = 11/104 (10%)
Query: 119 KDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDT-------L 171
K QIQ +E R ++EL+ L ++K +++ + + L YQ + L
Sbjct: 1810 KKQIQKLETR----IRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRL 1865
Query: 172 KDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKE 215
+D++++ + ++ + R+ EE ++ QH++EE +E
Sbjct: 1866 QDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEE 1909
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 64.7 bits (156), Expect = 2e-10
Identities = 96/413 (23%), Positives = 176/413 (42%), Gaps = 61/413 (14%)
Query: 22 EALSNIAREAEARLAAKRAARAE-------ARDIRMRELERQQKELDEKSDKQYAENYTR 74
+ L REA+A L +RAA E ++ RELE ++ +L + ++ E R
Sbjct: 971 QKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLAR 1030
Query: 75 PSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLK 134
+ + + R D L+ + SE + LK+ + + G +
Sbjct: 1031 LEAEKEELSEEIAALQQER----DEGLLL----AESEKQQALSLKESEKTALSEKLMGTR 1082
Query: 135 ELKESLSEVEEKYKKAMVSNAQLDNEK-NNLIYQVDTLKDVIEEQEEQMAEFYRENEEKS 193
++S E+ K+ S + D N L ++ L+ EE A+ R +E++
Sbjct: 1083 HSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQA 1142
Query: 194 KELERQKHMC-------SVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPV 246
++L +Q+ C +E+ ++GLR+ EL+E + E
Sbjct: 1143 RDLGKQRDSCLREAEELRTQLRLLEDARDGLRR--ELLEAQRKL------------RESQ 1188
Query: 247 AGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRK-------LKLQLEEERQ 299
G V QEA ++ S GEG + L EEL S ++K LKL E++ Q
Sbjct: 1189 EGR-EVQRQEAGELRRSLGEGAKE--REALRRSNEELRSAVKKAESERISLKLANEDKEQ 1245
Query: 300 KCSRND---GTVGDLAG-LQNGSDLQFIEMQR-DANRQISEYKFKLSKAEQDITTLEQSI 354
K + + VG AG L+ G LQ +E R +A R++ E + ++ + + T L + +
Sbjct: 1246 KLALLEEARTAVGKEAGELRTG--LQEVERSRLEARRELQELRRQMKMLDSENTRLGREL 1303
Query: 355 SRLEGQVLRYKTAAENAEKVEDELK-------AEKRKLQRELRTALDKIEEME 400
+ L+G++ + A + + + L+ A +++EL+ A K++E E
Sbjct: 1304 AELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQE 1356
Score = 55.8 bits (133), Expect = 7e-08
Identities = 84/371 (22%), Positives = 148/371 (39%), Gaps = 50/371 (13%)
Query: 78 RNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELK 137
R A+ L G ++ S S + L LRD D Q + R +Q L+
Sbjct: 539 RGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSAN 598
Query: 138 ESLSE-----------VEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFY 186
E LS +++ ++ +L + L Q D L++ E+ + A
Sbjct: 599 ELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVR 658
Query: 187 RENEEKSKELERQKHMCSVLQHKMEELKEGLR----QRDELIEKHGLVIIPDGTPNGDVS 242
RE E ++LE+ + SVL ++ E++E L QRD L +V+
Sbjct: 659 RELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDML-----------QAEKAEVA 707
Query: 243 HEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLS---QIRKLKLQLEEE-- 297
V E + A E L L KL+ E L + +L QLEEE
Sbjct: 708 EALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKS 767
Query: 298 ----RQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSK-----AEQDIT 348
RQ+ + + TV + L+ + ++++ RQ E ++++ EQ +
Sbjct: 768 ALQGRQRQAEQEATV----AREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLP 823
Query: 349 TLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKI--EEMEMTNSHL 406
TL S+L+ Q+ + E+ EL+ +R+ QR++ AL++ E+ + H
Sbjct: 824 TLRHERSQLQEQLAQLSRQLSGREQ---ELEQARREAQRQVE-ALERAAREKEALAKEHA 879
Query: 407 AKRLEKMKANR 417
++ + A R
Sbjct: 880 GLAVQLVAAER 890
Score = 45.4 bits (106), Expect = 1e-04
Identities = 86/428 (20%), Positives = 162/428 (37%), Gaps = 58/428 (13%)
Query: 4 PASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEK 63
P+ G +P + EA+ RE L + + R E R + L RQ E++ +
Sbjct: 1489 PSPGPATSPASP--DLDPEAVRGALREFLQELRSAQRERDELRT-QTSALNRQLAEMEAE 1545
Query: 64 SDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQ 123
D A + R + A + R + ++ R+ DQ+
Sbjct: 1546 RDS--ATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVA 1603
Query: 124 DVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMA 183
+E + L+ + L +EK K + +L+ +K L K+V++ E +
Sbjct: 1604 TLE----RSLQATESELRASQEKISKMKANETKLEGDKRRL-------KEVLDASESRTV 1652
Query: 184 EFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSH 243
+ + EL+R + S + + + L++ + D L + + GT V
Sbjct: 1653 KLELQRRSLEGELQRSRLGLSDREAQAQALQDRV---DSLQRQVADSEVKAGTLQLTV-- 1707
Query: 244 EPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLA---GEKEELLSQIRKLKLQLEEERQK 300
E + GA+ V + EG L ++R L + L+ R L L++
Sbjct: 1708 ERLNGALAKVEES---------EGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTA 1758
Query: 301 CSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQ-ISEYKFKLSKAEQDITTLEQSISRLE- 358
C D Q ++ + DA RQ +SE + + S + + TL ++ LE
Sbjct: 1759 CEH---------------DRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLEL 1803
Query: 359 ------GQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEK 412
GQ+ + + ++ E +KLQ E R +++ ++ + L EK
Sbjct: 1804 QRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQL--EAEK 1861
Query: 413 MKANRTAL 420
+ R+AL
Sbjct: 1862 REVERSAL 1869
Score = 40.4 bits (93), Expect = 0.003
Identities = 24/95 (25%), Positives = 53/95 (55%), Gaps = 7/95 (7%)
Query: 321 QFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEK--VEDEL 378
Q +E++R + + Y+ KL ++ Q + RL+G++L+YK E+ +E
Sbjct: 140 QSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSG 199
Query: 379 KAEKRKLQ-----RELRTALDKIEEMEMTNSHLAK 408
+ E+++L+ ++L +AL ++EE + ++ LA+
Sbjct: 200 ELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQ 234
Score = 39.3 bits (90), Expect = 0.007
Identities = 77/371 (20%), Positives = 156/371 (42%), Gaps = 34/371 (9%)
Query: 9 KRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIR--MRELERQQKELDEKSDK 66
++T + ++ +L+ I+ E E + KR A++ R + L + ++L + ++
Sbjct: 1070 EKTALSEKLMGTRHSLATISLEMERQ---KRDAQSRQEQDRSTVNALTSELRDLRAQREE 1126
Query: 67 QYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVE 126
A + A L + G S L + + ++LR + D +D ++
Sbjct: 1127 AAAAH---------AQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRREL 1177
Query: 127 GRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFY 186
+ L+E +E ++ + S + E+ L + L+ +++ E +
Sbjct: 1178 LEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLK 1237
Query: 187 RENEEKSKELERQKHMCSVLQHKMEELKEGLRQ--------RDELIEKHGLVIIPDGTPN 238
NE+K ++L + + + + EL+ GL++ R EL E + + D + N
Sbjct: 1238 LANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLD-SEN 1296
Query: 239 GDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGE------KEELLSQIRKLKL 292
+ E + E A+ + + L +R R L GE ++EL RKL+
Sbjct: 1297 TRLGRELAELQGRLALGERAE--KESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQE 1354
Query: 293 QLEEERQKCSRNDGTVGDLAGL--QNGSDLQFIEMQRDANR-QISEYKFKLSKAEQDITT 349
Q E R + R G++ + G Q + +E++ +A R + +E +LS AE
Sbjct: 1355 QEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQG 1414
Query: 350 LEQSISRLEGQ 360
LE ++R+E Q
Sbjct: 1415 LEAELARVEVQ 1425
Score = 30.0 bits (66), Expect = 4.1
Identities = 66/323 (20%), Positives = 131/323 (40%), Gaps = 32/323 (9%)
Query: 112 LRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTL 171
+R +L+ Q+Q+ + Y + L+ +E + ++ Q + L Q+
Sbjct: 138 VRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLER 197
Query: 172 KDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQ---RDELIEKHG 228
+E+Q + E ++ E LE ++ + L L+E L Q ++ + +
Sbjct: 198 SGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDI 257
Query: 229 LVIIPDGTP-NGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQI 287
+ D T ++ H A +E+ S L + R++ G + L+S++
Sbjct: 258 RKVTNDWTRCRKELEHREAAWR---REEESFNAYFSNEHSRLLLLWRQVVGFR-RLVSEV 313
Query: 288 RKLK----LQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKA 343
+ LQL E + SR AGL + L+ E + +A
Sbjct: 314 KMFTERDLLQLGGELARTSR----AVQEAGLGLSTGLRLAESRAEA------------AL 357
Query: 344 EQDITTLEQSISRLEGQVLRYKTAAENAEKVEDEL-KAEKRKLQRELRTALDKIEEMEMT 402
E+ Q +L +VLR K A+ ++++ +L KA+ EL A+ ++E+ +
Sbjct: 358 EKQALLQAQLEEQLRDKVLREKDLAQ--QQMQSDLDKADLSARVTELGLAVKRLEKQNLE 415
Query: 403 NSHLAKRL-EKMKANRTALLAQQ 424
+ K L EK++A + L +Q
Sbjct: 416 KDQVNKDLTEKLEALESLRLQEQ 438
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 63.9 bits (154), Expect = 3e-10
Identities = 93/421 (22%), Positives = 165/421 (39%), Gaps = 66/421 (15%)
Query: 12 PVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELD--------EK 63
P +++ + L + EA A + +AR + M E ER Q+E E+
Sbjct: 401 PPQEKGEVLGDVLQLETLKQEAATLAANNTQLQAR-VEMLETERGQQEAKLLAERGHFEE 459
Query: 64 SDKQYAENYT--RPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQ 121
+Q + T + S N + A L S G+ T+ + + L+ L +DQ
Sbjct: 460 EKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQ 519
Query: 122 IQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQ 181
+ GLK+ + +EK + + Q + L +QV+ L ++++E+Q
Sbjct: 520 -------ELAGLKQ------QAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQ 566
Query: 182 MAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRD------ELIEKHG---LVII 232
+ E + +E RQ H L EE + LR+RD E +EK L I+
Sbjct: 567 LKEV-----AEKQEATRQDH-AQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEIL 620
Query: 233 PDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKL 292
+ + + ++T +E A++ E L + E+ E +Q+ +L+L
Sbjct: 621 QQQLQVANEARDSAQTSVTQAQREKAELSRKVEE--LQACVETARQEQHEAQAQVAELEL 678
Query: 293 QLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQ 352
QL E+QK + + + LQ Q + K++K
Sbjct: 679 QLRSEQQKATEKERVAQEKDQLQE-------------QLQALKESLKVTKGS-------- 717
Query: 353 SISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEK 412
LE + R A E ++ ELKAE R L + + ++EE L RL++
Sbjct: 718 ----LEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQ 773
Query: 413 M 413
+
Sbjct: 774 L 774
Score = 60.8 bits (146), Expect = 2e-09
Identities = 85/395 (21%), Positives = 169/395 (42%), Gaps = 45/395 (11%)
Query: 34 RLAAKRAARAEARDIRMRELERQQKELDEKSDKQYA---ENYTRPSSRNSASATTPLSGN 90
RL + A RD EL +K L EK D Q A + R + N A +PL
Sbjct: 218 RLKKQLADERSNRDELELELAENRKLLTEK-DAQIAMMQQRIDRLALLNEKQAASPL--- 273
Query: 91 SSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKE---LKESLSEVEEKY 147
E +++ +L+D+ + + R + LK+ LK S+++ K
Sbjct: 274 --------------------EPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKI 313
Query: 148 KKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQ 207
+ N L + + L+D + E E+ ++ +E EK +LE K + + LQ
Sbjct: 314 NQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLE--KELSAALQ 371
Query: 208 HK--MEELKEGLRQRDELIEKHGLVIIPDGTP--NGDVSHEPVAGAITVVSQEAAQVLES 263
K +EE E L+ + +E+H L + D P G+V + + + + QEAA + +
Sbjct: 372 DKKCLEEKNEILQGKLSQLEEH-LSQLQDNPPQEKGEVLGDVL--QLETLKQEAATL--A 426
Query: 264 AGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFI 323
A L R+ L E+ + +++ + EEE+Q+ S + DL +
Sbjct: 427 ANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLS---SLITDLQSSISNLSQAKE 483
Query: 324 EMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKR 383
E+++ + + +++ ++TTL +I + + ++ K A+ + + ++
Sbjct: 484 ELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQE 543
Query: 384 KLQRELRTALDKI-EEMEMTNSHLAKRLEKMKANR 417
+ + LR ++++ ++ L + EK +A R
Sbjct: 544 QASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR 578
Score = 50.1 bits (118), Expect = 4e-06
Identities = 106/476 (22%), Positives = 192/476 (40%), Gaps = 88/476 (18%)
Query: 10 RTPVKDRFSAEDEALSNIAR---EAEARLAAKRAARAEARDIRMRELER--QQKELD--- 61
RT V+D AEDE + +AR EAE + + + E + + LE+ + KEL
Sbjct: 1196 RTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLV 1255
Query: 62 --EKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDL- 118
E Q E R +AS +S R + +S+L + SL E + +
Sbjct: 1256 MAESEKSQKLEERLRLLQAETAS--------NSARAAERSSALREEVQSLREEAEKQRVA 1307
Query: 119 KDQIQDVEGRYMQGLKELKESLSEVEEKY--KKAMVSNAQLDNEKNN-LIYQVDTLKDVI 175
+ ++ + +EL + L +EK+ K+ +S QL++ L+ ++ K +
Sbjct: 1308 SENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLC 1367
Query: 176 EE-QEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEK-------- 226
++ Q EQ A R EE + + + + L EL E + R ++ E+
Sbjct: 1368 QQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLR 1427
Query: 227 ----------------HGLVI-----IPDGTPNG--------DVSHEPVAGAITVVSQEA 257
HGL+ + + G D + E + V +A
Sbjct: 1428 AEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADA 1487
Query: 258 ----AQVLESAGE--GPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDL 311
A+V A L+V K G K ++L + + + +EERQK + V L
Sbjct: 1488 ETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEE----RQRFQEERQKLT---AQVEQL 1540
Query: 312 AGLQNGSDLQFIEMQR-----DANRQISEYKFKLSKA-----EQDITTLEQSISRLEGQV 361
Q Q E+ + D ++ + K K +A +Q+ L+ ++ L+ Q+
Sbjct: 1541 EVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQL 1600
Query: 362 LRYKTAAEN----AEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKM 413
+ + AAE+ EK + A+K++ Q EL+ L +E+++ N L E++
Sbjct: 1601 SQKEQAAEHYKLQMEKAKTHYDAKKQQNQ-ELQEQLRSLEQLQKENKELRAEAERL 1655
Score = 47.0 bits (110), Expect = 3e-05
Identities = 96/440 (21%), Positives = 166/440 (37%), Gaps = 78/440 (17%)
Query: 15 DRFSAEDEALSNIAREAEARLAAKRAARAE--ARDIRMRELERQQKELDEKSDKQYAENY 72
+R SA E + ++ EAE + A R E ++ R EL ++ K EK +
Sbjct: 1285 ERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQ------ 1338
Query: 73 TRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQD----VEGR 128
+ A +T L S T +L+ SEL L Q+Q E R
Sbjct: 1339 -----KEQALSTLQLEHTS-------TQALV------SELLPAKHLCQQLQAEQAAAEKR 1380
Query: 129 YMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRE 188
+ + L++ K++ + + +A E LI L+ + EQE + E
Sbjct: 1381 HREELEQSKQAAGGLRAELLRAQ-------RELGELI----PLRQKVAEQERTAQQLRAE 1429
Query: 189 NEEKSKELERQKHMCSVLQHKMEELKEGL------------RQRDELIEKHGLVIIPDGT 236
+++L K +L + L E + R++ +++ V T
Sbjct: 1430 KASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAET 1489
Query: 237 PNGDVSHEPVAGA----ITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKL 292
+V E + A + E A+V +KL + E+L R+
Sbjct: 1490 RLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTK 1549
Query: 293 QLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANR----------QISE------- 335
Q+EE +K + +D Q E Q++A R Q+S+
Sbjct: 1550 QVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEH 1609
Query: 336 YKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDK 395
YK ++ KA+ +Q L+ Q+ + E +K EL+AE +L EL+ A K
Sbjct: 1610 YKLQMEKAKTHYDAKKQQNQELQEQL----RSLEQLQKENKELRAEAERLGHELQQAGLK 1665
Query: 396 IEEMEMTNSHLAKRLEKMKA 415
+E E T HL ++ ++A
Sbjct: 1666 TKEAEQTCRHLTAQVRSLEA 1685
Score = 43.9 bits (102), Expect = 3e-04
Identities = 84/416 (20%), Positives = 162/416 (38%), Gaps = 68/416 (16%)
Query: 26 NIAREAEARLAAKRAARAEARDIRMRELERQQKELDEK---SDKQYA--ENYTRPSSRNS 80
N E A LA + + + +++R ++L L EK + K+ A E R +
Sbjct: 872 NELAELHANLA-RALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQ 930
Query: 81 ASATTPLSGNSSRRGSGDTSSLIDPD--------TSLSEL-RDIYDLKDQIQDVEGRYMQ 131
+A+ L +R G L + +L + R+ + ++++ + M+
Sbjct: 931 ETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALME 990
Query: 132 GLKELKESLSEVEEKYKKAMV----SNAQLDNEKNNLIYQVDTLKDVIEEQ-------EE 180
+ +E + E + + + A L EK L++ + EQ +E
Sbjct: 991 SQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQE 1050
Query: 181 QMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGD 240
+A E E K +EL + + + + ++EEL++ ++Q E + K +
Sbjct: 1051 ALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKK------------E 1098
Query: 241 VSHEPVAGAITVVSQEAAQVLESAGEG--PLDVRLRKLAGEKEELLSQIRKLKLQLEEER 298
H +GA EAA E G L + KL + ++ Q L+ LE ER
Sbjct: 1099 KEHASGSGA----QSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAER 1154
Query: 299 QKCSRNDGTVGDLAGLQNGSDLQFIEMQR---DANRQISEYKFKL---SKAEQD------ 346
+ D + L G + Q A R+++ ++ K+ SKAE +
Sbjct: 1155 ASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVA 1214
Query: 347 ------------ITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELR 390
I++LE+ +S L QVL + ++ +++ + +KL+ LR
Sbjct: 1215 RGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLR 1270
Score = 33.1 bits (74), Expect = 0.49
Identities = 30/129 (23%), Positives = 59/129 (45%), Gaps = 28/129 (21%)
Query: 286 QIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQ 345
Q+R+LK QL +ER S+ +E++ NR++ L++ +
Sbjct: 215 QMRRLKKQLADER-------------------SNRDELELELAENRKL------LTEKDA 249
Query: 346 DITTLEQSISRLEGQVLRYKTAAENAEKVE-DELKAEKRKLQRELRTALDKIEEMEMTNS 404
I ++Q I RL +L K AA E E +EL+ + L L L + ++++ S
Sbjct: 250 QIAMMQQRIDRL--ALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKS 307
Query: 405 HLAKRLEKM 413
+ +++ ++
Sbjct: 308 QMDRKINQL 316
Score = 33.1 bits (74), Expect = 0.49
Identities = 42/210 (20%), Positives = 76/210 (36%), Gaps = 20/210 (9%)
Query: 10 RTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYA 69
R + R + + ARE E A A+ + + R R E +QK + +
Sbjct: 1484 RADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVF 1543
Query: 70 ENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRY 129
+ T + S + D +S + +L+ + + Q R
Sbjct: 1544 QR----------EQTKQVEELSKKLADSDQASKVQQ----QKLKAVQAQGGESQQEAQRL 1589
Query: 130 MQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKD-VIEEQEEQMAEFYRE 188
L EL+ LS+ K+ + +L EK Y ++ ++EQ + + +E
Sbjct: 1590 QAQLNELQAQLSQ-----KEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKE 1644
Query: 189 NEEKSKELERQKHMCSVLQHKMEELKEGLR 218
N+E E ER H K +E ++ R
Sbjct: 1645 NKELRAEAERLGHELQQAGLKTKEAEQTCR 1674
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 61.2 bits (147), Expect = 2e-09
Identities = 92/439 (20%), Positives = 180/439 (41%), Gaps = 63/439 (14%)
Query: 30 EAEARLAAKRAARAEARDIRM---RELERQQKELDEK----------SDKQYAENYTRPS 76
E E L A+R ARA+ +R RELE + L+E + K+ AE
Sbjct: 1117 ELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRR 1176
Query: 77 SRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKEL 136
A+ + + R+ D S++EL + D +Q V+ + + E
Sbjct: 1177 DLEEATLQHEATAAALRKKHAD---------SVAELGEQID---NLQRVKQKLEKEKSEF 1224
Query: 137 KESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEE-------QMAEFYREN 189
K L +V ++ + + A L+ L Q++ + EE + Q A+ EN
Sbjct: 1225 KLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTEN 1284
Query: 190 EEKSKELERQKHMCSVLQH-------KMEELKEGLRQRDELIEKHGLV-IIPDGTPNGDV 241
E S++L+ ++ + S L ++E+LK L + E+ K+ L + + D+
Sbjct: 1285 GELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEE--EVKAKNALAHALQSARHDCDL 1342
Query: 242 SHEPVAGAITVVSQEAAQVLESAG----------EGPLDVRLRKLAGEKEELLSQIRKLK 291
E T E +VL A E R +L K++L ++++ +
Sbjct: 1343 LREQYEEE-TEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE 1401
Query: 292 LQLEEERQKCSRNDGT-------VGDL---AGLQNGSDLQFIEMQRDANRQISEYKFKLS 341
+E KCS + T + DL N + + QR+ ++ ++E+K K
Sbjct: 1402 EAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYE 1461
Query: 342 KAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEM 401
+++ ++ + ++ L ++ + K A E + + + K E + LQ E+ +++
Sbjct: 1462 ESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGK 1521
Query: 402 TNSHLAKRLEKMKANRTAL 420
T L K ++++A + L
Sbjct: 1522 TIHELEKVRKQLEAEKMEL 1540
Score = 57.4 bits (137), Expect = 2e-08
Identities = 61/294 (20%), Positives = 126/294 (42%), Gaps = 52/294 (17%)
Query: 133 LKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEK 192
+ +KE + ++E +K+ +L+ + +L+ + + L+ ++ +++ +A+ EE+
Sbjct: 849 MASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADA----EER 904
Query: 193 SKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITV 252
+L + K L+ K++E+ E L +E+
Sbjct: 905 CDQLIKNKIQ---LEAKVKEMNERLEDEEEM----------------------------- 932
Query: 253 VSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLA 312
L + RKL E EL I L+L L + ++ + V +L
Sbjct: 933 -------------NAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLT 979
Query: 313 GLQNGSD--LQFIEMQRDANRQISEYKFKLSKAEQD-ITTLEQSISRLEGQVLRYKTAAE 369
G D + + ++ A ++ + +AE+D + TL ++ +LE QV + + E
Sbjct: 980 EEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLE 1039
Query: 370 NAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQ 423
+KV +L+ KRKL+ +L+ + I ++E L +RL+K AL A+
Sbjct: 1040 QEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNAR 1093
Score = 55.8 bits (133), Expect = 7e-08
Identities = 83/411 (20%), Positives = 176/411 (42%), Gaps = 48/411 (11%)
Query: 13 VKDRFSAEDEALSNIAREAEARLAAKRA----ARAEARDIRMRELERQQKELDEKSDKQY 68
V+ + AE L + EAEA L + A+ E I+ E+ER+ E DE+ + Q
Sbjct: 1529 VRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKA-EIERKLAEKDEEME-QA 1586
Query: 69 AENYTR--PSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSEL-RDIYDLKDQIQDV 125
N+ R S + S A T + R L + + LS R + + Q++ +
Sbjct: 1587 KRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSL 1646
Query: 126 EGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIY-QVDTLKDVIEEQEEQMAE 184
+ +L +++ ++ + N + +NNL+ +++ L+ V+E+ E
Sbjct: 1647 QSLLKDTQIQLDDAVRANDD-----LKENIAIVERRNNLLQAELEELRAVVEQTERSRKL 1701
Query: 185 FYRENEEKSKELE-----------RQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIP 233
+E E S+ ++ ++K M + L E++E +++ EK I
Sbjct: 1702 AEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITD 1761
Query: 234 DGTPNGDVSHEPVAGA-ITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELL---SQIRK 289
++ E A + + + Q ++ + L G K++L +++R+
Sbjct: 1762 AAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRE 1821
Query: 290 LKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITT 349
L+ +LE E+++ + + ++ R + R+I E ++ + +++
Sbjct: 1822 LENELEAEQKR------------------NAESVKGMRKSERRIKELTYQTEEDRKNLLR 1863
Query: 350 LEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEME 400
L+ + +L+ +V YK AE AE+ + ++ RK+Q EL A ++ + E
Sbjct: 1864 LQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAE 1914
Score = 50.4 bits (119), Expect = 3e-06
Identities = 77/319 (24%), Positives = 147/319 (46%), Gaps = 61/319 (19%)
Query: 130 MQGLKE----LKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEE----- 180
M +KE LKE+L + E + K+ L EKN+L QV +D + + EE
Sbjct: 849 MASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQL 908
Query: 181 ------------QMAEFYRENEEKSKELERQKHM----CSVLQHKMEELKEGLRQRDELI 224
+M E + EE + EL +K CS L+ +++L+ L + ++
Sbjct: 909 IKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEK-- 966
Query: 225 EKHGLVIIPDGTPNGDVS-HEPVAGAITVVSQ--EAAQVLESAGEGPLDVRLRKLAGEKE 281
EKH T N + E +AG ++++ + + L+ A + LD L E E
Sbjct: 967 EKHA-------TENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD----DLQAE-E 1014
Query: 282 ELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLS 341
+ ++ + K K++LE++ V DL GS Q +++ D R + + L
Sbjct: 1015 DKVNTLTKAKVKLEQQ----------VDDL----EGSLEQEKKVRMDLERAKRKLEGDLK 1060
Query: 342 KAEQDITTLEQSISRLEGQVLR--YKTAAENAEKVEDE--LKAEKRKLQRELRTALDKIE 397
++ I LE +L+ ++ + ++ A NA ++EDE L ++ +K +EL+ ++++E
Sbjct: 1061 LTQESIMDLENDKQQLDERLKKKDFELNALNA-RIEDEQALGSQLQKKLKELQARIEELE 1119
Query: 398 EMEMTNSHLAKRLEKMKAN 416
E ++EK++++
Sbjct: 1120 EELEAERTARAKVEKLRSD 1138
Score = 46.6 bits (109), Expect = 4e-05
Identities = 91/462 (19%), Positives = 184/462 (39%), Gaps = 86/462 (18%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAAR--AEARDIRMRELERQQKELDE 62
A+ K + + + DE ++ + +E +A A + A +A + ++ L + + +L++
Sbjct: 970 ATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQ 1029
Query: 63 KSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTS----SLIDPDTSLSELRDIYDL 118
+ D R + R+ GD S++D + +L +
Sbjct: 1030 QVDDLEGSLEQEKKVRMDLE-------RAKRKLEGDLKLTQESIMDLENDKQQLDERLKK 1082
Query: 119 KD--------QIQDVEG---RYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQ 167
KD +I+D + + + LKEL+ + E+EE+ + + A+++ +++L +
Sbjct: 1083 KDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRE 1142
Query: 168 VDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKH 227
++ + + +EE + N+++ E ++ + + E LR +KH
Sbjct: 1143 LEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALR------KKH 1196
Query: 228 GLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLE-SAGEGPLDV-----RLRKLAGEKE 281
+ G ++ Q Q LE E L++ + ++ K
Sbjct: 1197 ADSVAELGEQIDNL-------------QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKA 1243
Query: 282 ELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLS 341
L R L+ Q+ E R K +V DL + + E+ +RQ+ E + +S
Sbjct: 1244 NLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGEL----SRQLDEKEALIS 1299
Query: 342 KAEQDITTLEQSISRLEGQVLRYKTAAENA----------------EKVEDELKAEKRKL 385
+ + T Q + L+ Q L + A+NA E+ E+E +A K +L
Sbjct: 1300 QLTRGKLTYTQQLEDLKRQ-LEEEVKAKNALAHALQSARHDCDLLREQYEEETEA-KAEL 1357
Query: 386 QREL----------RT-----ALDKIEEMEMTNSHLAKRLEK 412
QR L RT A+ + EE+E LA+RL++
Sbjct: 1358 QRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQE 1399
Score = 45.8 bits (107), Expect = 7e-05
Identities = 67/294 (22%), Positives = 119/294 (40%), Gaps = 51/294 (17%)
Query: 112 LRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTL 171
L D + DQ+ + + +KE+ E L + EE NA+L +K L + L
Sbjct: 898 LADAEERCDQLIKNKIQLEAKVKEMNERLEDEEE-------MNAELTAKKRKLEDECSEL 950
Query: 172 KDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVI 231
K I++ E +A ++E++KH ++K++ L E + DE+I K
Sbjct: 951 KRDIDDLELTLA-----------KVEKEKH---ATENKVKNLTEEMAGLDEIIAKL---- 992
Query: 232 IPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLK 291
T E A+ + E +V V+L + + E L Q +K++
Sbjct: 993 ----TKEKKALQEAHQQALDDLQAEEDKVNTLT---KAKVKLEQQVDDLEGSLEQEKKVR 1045
Query: 292 LQLEEERQKCSRNDGTVGDLAGLQNG-SDLQFIEMQRD------------ANRQISEYKF 338
+ LE ++K GDL Q DL+ + Q D N +I + +
Sbjct: 1046 MDLERAKRKLE------GDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQA 1099
Query: 339 KLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTA 392
S+ ++ + L+ I LE ++ +TA EK+ +L E ++ L A
Sbjct: 1100 LGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEA 1153
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 60.8 bits (146), Expect = 2e-09
Identities = 73/303 (24%), Positives = 125/303 (41%), Gaps = 51/303 (16%)
Query: 121 QIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEE 180
+++ ++ + M +L+E L E +A A+L +K L L+ +EE+EE
Sbjct: 870 EMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEE 929
Query: 181 QMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGD 240
+ E ++ +Q ++EL+E L + + +K L
Sbjct: 930 RCQHLQAEKKK--------------MQQNIQELEEQLEEEESARQKLQL----------- 964
Query: 241 VSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQK 300
E V + E Q++ L+ + KLA EK+ L +I + L EE +K
Sbjct: 965 ---EKVTTEAKLKKLEEEQII-------LEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEK 1014
Query: 301 CSRNDGTVGDLAGLQNGSDLQFIEMQ---RDANRQISEYKFKLSKAEQDITTLEQSISRL 357
LA L+N + +++ R +Q E + K E D T L I+ L
Sbjct: 1015 SK-------SLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAEL 1067
Query: 358 EGQVLRYKTAAENAEKVEDELKAEKRKLQREL---RTALDKIEEMEMTNSHLAKRLEKMK 414
+ Q+ K K E+EL+A +++ E AL KI E+E S L + LE +
Sbjct: 1068 QAQIAELKM---QLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESER 1124
Query: 415 ANR 417
A+R
Sbjct: 1125 ASR 1127
Score = 59.7 bits (143), Expect = 5e-09
Identities = 96/425 (22%), Positives = 164/425 (38%), Gaps = 97/425 (22%)
Query: 13 VKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENY 72
+K + + ++E L E A K A ++RELE Q EL E + + A
Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQKNMALK-----KIRELESQISELQEDLESERA--- 1125
Query: 73 TRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELR-----DIYDLKD------- 120
SRN A G + +D + ELR ++ LK
Sbjct: 1126 ----SRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAK 1181
Query: 121 ----QIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIE 176
QIQ++ ++ Q ++EL E L + + + L+NE+ L +V L
Sbjct: 1182 THEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVL----- 1236
Query: 177 EQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGT 236
+ ++E K K++E Q LQ + EG R R EL +K
Sbjct: 1237 ------LQGKGDSEHKRKKVEAQ------LQELQVKFNEGERVRTELADK---------- 1274
Query: 237 PNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEE 296
+T + E V + D + KL + L SQ++ + L+E
Sbjct: 1275 -------------VTKLQVELDNVTGLLSQS--DSKSSKLTKDFSALESQLQDTQELLQE 1319
Query: 297 E-RQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSIS 355
E RQK S + + L+ +E ++++ R+ +L + E+ LE+ I+
Sbjct: 1320 ENRQKLSLS-------------TKLKQVEDEKNSFRE------QLEEEEEAKHNLEKQIA 1360
Query: 356 RLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEE-------MEMTNSHLAK 408
L QV K E++ + + KRKLQ++L + EE +E T + L +
Sbjct: 1361 TLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQ 1420
Query: 409 RLEKM 413
L+ +
Sbjct: 1421 ELDDL 1425
Score = 58.5 bits (140), Expect = 1e-08
Identities = 92/439 (20%), Positives = 184/439 (41%), Gaps = 94/439 (21%)
Query: 9 KRTPVKDRFSAEDEALSNIAREAEARLAAKRA----------ARAEARDIRMRELERQQK 58
++ ++++ AE E + A E ARL AK+ AR E + R + L+ ++K
Sbjct: 881 EKLQLQEQLQAETELCAE-AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKK 939
Query: 59 ELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDL 118
++ + + + S+R + ++ + L D + L++ + + L
Sbjct: 940 KMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKL--L 997
Query: 119 KDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQ 178
+D+I E +L+E EEK K S A+L N+ +I ++ E+Q
Sbjct: 998 EDRIA-----------EFTTNLTEEEEKSK----SLAKLKNKHEAMITDLEERLRREEKQ 1042
Query: 179 EEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPN 238
+++ + R+ E S +L Q + LQ ++ ELK L +++E ++
Sbjct: 1043 RQELEKTRRKLEGDSTDLSDQ---IAELQAQIAELKMQLAKKEEELQ------------- 1086
Query: 239 GDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEER 298
A+ V +EAAQ ++ L+K+ EL SQI +L+ LE ER
Sbjct: 1087 ---------AALARVEEEAAQ---------KNMALKKI----RELESQISELQEDLESER 1124
Query: 299 QKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKL-SKAEQDITTLE------ 351
++ + DL G +L+ ++ + + + + +L SK EQ++ L+
Sbjct: 1125 ASRNKAEKQKRDL-----GEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEE 1179
Query: 352 ----------------QSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDK 395
Q++ L Q+ + K N EK + L+ E+ +L E++ L
Sbjct: 1180 AKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQG 1239
Query: 396 IEEMEMTNSHLAKRLEKMK 414
+ E + +L++++
Sbjct: 1240 KGDSEHKRKKVEAQLQELQ 1258
Score = 57.4 bits (137), Expect = 2e-08
Identities = 63/298 (21%), Positives = 125/298 (41%), Gaps = 45/298 (15%)
Query: 133 LKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEK 192
L +++E E + + +QL EK L Q+ ++ E EE A + +E
Sbjct: 854 LVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQEL 913
Query: 193 SK-------ELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEP 245
+ +E ++ C LQ + +++++ +++ +E +E+ + + + E
Sbjct: 914 EEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEE-------EESARQKLQLEK 966
Query: 246 VAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRND 305
V + E Q++ L+ + KLA EK+ L +I + L EE +K
Sbjct: 967 VTTEAKLKKLEEEQII-------LEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSK--- 1016
Query: 306 GTVGDLAGLQNGSDLQFIEMQ---RDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVL 362
LA L+N + +++ R +Q E + K E D T L I+ L+ Q+
Sbjct: 1017 ----SLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIA 1072
Query: 363 RYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTAL 420
ELK + K + EL+ AL ++EE + K++ ++++ + L
Sbjct: 1073 --------------ELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISEL 1116
Score = 52.4 bits (124), Expect = 8e-07
Identities = 90/442 (20%), Positives = 170/442 (38%), Gaps = 60/442 (13%)
Query: 10 RTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYA 69
RT ++D S++D+ + + +KRA + +++ +LE + EL D +
Sbjct: 1503 RTEMEDLMSSKDD----VGKSVHELEKSKRALEQQVEEMKT-QLEELEDELQATEDAKLR 1557
Query: 70 ENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRY 129
+ + A L G + + +EL D + +
Sbjct: 1558 LEVNLQAMK--AQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKL 1615
Query: 130 MQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYREN 189
LK+L+ + + +A+ +L + + + ++D D +EE +A+ +EN
Sbjct: 1616 EMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELD---DTRASREEILAQA-KEN 1671
Query: 190 EEKSKELERQKHMCSVLQHKMEELKEGLRQ----RDELIEKHGLVIIPDGTPNGDVSHEP 245
E+K K +E + LQ ++ + RQ RDEL ++ I + + G ++ E
Sbjct: 1672 EKKLKSMEAEMIQ---LQEELAAAERAKRQAQQERDELADE-----IANSSGKGALALEE 1723
Query: 246 VAGAITVVSQEAAQVLESAGEGPL-----------------DVRLRKLAGEKEELLSQIR 288
++Q ++ E G L D+ L + +K E Q
Sbjct: 1724 KRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQ-- 1781
Query: 289 KLKLQLEEERQKCSRNDGTV------------GDLAGLQNGSDLQFIEMQ---RDANRQI 333
+L+ Q +E + K +GTV +A L+ D + E Q + R
Sbjct: 1782 QLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTE 1841
Query: 334 SEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELK---AEKRKLQRELR 390
+ K L + + + EQ + + R K E+ E+E + A +RKLQREL
Sbjct: 1842 KKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELE 1901
Query: 391 TALDKIEEMEMTNSHLAKRLEK 412
A + + M S L +L +
Sbjct: 1902 DATETADAMNREVSSLKNKLRR 1923
Score = 51.6 bits (122), Expect = 1e-06
Identities = 62/275 (22%), Positives = 120/275 (43%), Gaps = 28/275 (10%)
Query: 164 LIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDEL 223
L +V L V ++EE MA+ + + K+L + + + + + + E L+ +++L
Sbjct: 830 LFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQL 889
Query: 224 IEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQV---LESAGEGPLDVRLRKLAGEK 280
+ L E + +T QE ++ LE+ E + R + L EK
Sbjct: 890 QAETELC----------AEAEELRARLTAKKQELEEICHDLEARVEEE-EERCQHLQAEK 938
Query: 281 EELLSQIRKLKLQLEEE---RQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANR------ 331
+++ I++L+ QLEEE RQK T A L+ + Q I ++
Sbjct: 939 KKMQQNIQELEEQLEEEESARQKLQLEKVTTE--AKLKKLEEEQIILEDQNCKLAKEKKL 996
Query: 332 ---QISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRE 388
+I+E+ L++ E+ +L + ++ E + + EK EL+ +RKL+ +
Sbjct: 997 LEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGD 1056
Query: 389 LRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQ 423
D+I E++ + L +L K + A LA+
Sbjct: 1057 STDLSDQIAELQAQIAELKMQLAKKEEELQAALAR 1091
Score = 50.8 bits (120), Expect = 2e-06
Identities = 90/438 (20%), Positives = 180/438 (41%), Gaps = 58/438 (13%)
Query: 38 KRAARAEARDIRMRELERQQKELDEKSDKQYAE--NYT---RPSSRNSASATTPLSGNSS 92
K A+ + ++ E ER + EL +K K E N T S S+ T S S
Sbjct: 1249 KVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALES 1308
Query: 93 RRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMV 152
+ DT L+ + +L LK Q++D + + + L+E +E+ +E++
Sbjct: 1309 QLQ--DTQELLQEENR-QKLSLSTKLK-QVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364
Query: 153 SNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEE 212
A + + + + ++T ++V + ++ + + +EEK ++ + + LQ ++++
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDD 1424
Query: 213 LKEGLRQR-------DELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEA-----AQV 260
L L + ++ +K ++ + T + + E +E A+
Sbjct: 1425 LLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARA 1484
Query: 261 LESAGEGPLDV-RLRK-LAGEKEELLS---------------------QIRKLKLQLEE- 296
LE A E ++ RL K E E+L+S Q+ ++K QLEE
Sbjct: 1485 LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEEL 1544
Query: 297 ERQKCSRNDGTVGDLAGLQ----------NGSDLQFIEMQRDANRQISEYKFKLSKAEQD 346
E + + D + LQ G D Q E ++ RQ+ E + +L +
Sbjct: 1545 EDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQ 1604
Query: 347 ITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHL 406
+ + +LE + + ++A K DE + RKLQ +++ D + E++ T +
Sbjct: 1605 RSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMK---DCMRELDDTRASR 1661
Query: 407 AKRLEKMKANRTALLAQQ 424
+ L + K N L + +
Sbjct: 1662 EEILAQAKENEKKLKSME 1679
Score = 38.9 bits (89), Expect = 0.009
Identities = 51/241 (21%), Positives = 92/241 (38%), Gaps = 31/241 (12%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRE-LERQQKELD-- 61
A KR ++R DE ++ + A LA + R EAR ++ E LE +Q +
Sbjct: 1692 AERAKRQAQQERDELADEIANSSGKGA---LALEEKRRLEARIAQLEEELEEEQGNTELI 1748
Query: 62 --------------------EKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSS 101
E+S Q EN + R + L S +S
Sbjct: 1749 NDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKAS 1808
Query: 102 LIDPDTSLSELRDIYDLKDQIQDVEGRYMQGL-KELKESLSEVEEKYKKAMVSNAQLDNE 160
+ + +++L + D + + + + ++ K+LK+ L +V+++ + A Q D
Sbjct: 1809 ITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKA 1868
Query: 161 KNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR 220
L LK +EE EE+ + +ELE + ++ LK LR+
Sbjct: 1869 STRL----KQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRG 1924
Query: 221 D 221
D
Sbjct: 1925 D 1925
Score = 33.9 bits (76), Expect = 0.29
Identities = 67/329 (20%), Positives = 128/329 (38%), Gaps = 59/329 (17%)
Query: 24 LSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNSASA 83
+ + RE + A++ A+A++ ++L+ + E+ + ++ A + ++
Sbjct: 1647 MKDCMRELDDTRASREEILAQAKE-NEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDE 1705
Query: 84 TTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEV 143
NSS +G+ +L E R + E R Q +EL+E
Sbjct: 1706 LADEIANSSGKGA----------LALEEKRRL----------EARIAQLEEELEEEQGNT 1745
Query: 144 EEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEE---KSKELE--- 197
E + +N Q+D +L + + ++ E + R+N+E K +E+E
Sbjct: 1746 ELINDRLKKANLQIDQINTDLNLE----RSHAQKNENARQQLERQNKELKVKLQEMEGTV 1801
Query: 198 RQKHMCSV--LQHKMEELKEGLR-------------QRDELIEKHGLVIIPDGTPNGDVS 242
+ K+ S+ L+ K+ +L+E L +R E K L+ + D N +
Sbjct: 1802 KSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQY 1861
Query: 243 HEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCS 302
+ A T + Q Q LE A E E + + RKL+ +LE+ +
Sbjct: 1862 KDQADKASTRLKQLKRQ-LEEAEE------------EAQRANASRRKLQRELEDATETAD 1908
Query: 303 RNDGTVGDLAGLQNGSDLQFIEMQRDANR 331
+ V L DL F+ +R A +
Sbjct: 1909 AMNREVSSLKNKLRRGDLPFVVPRRMARK 1937
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 60.5 bits (145), Expect = 3e-09
Identities = 86/437 (19%), Positives = 177/437 (40%), Gaps = 59/437 (13%)
Query: 30 EAEARLAAKRAARAEARDIRM---RELERQQKELDEK----------SDKQYAENYTRPS 76
E E L A+R ARA+ +R RELE + L+E + K+ AE
Sbjct: 1119 ELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRR 1178
Query: 77 SRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKEL 136
A+ + + R+ D S++EL + D +Q V+ + + E
Sbjct: 1179 DLEEATLQHEATAAALRKKHAD---------SVAELGEQID---NLQRVKQKLEKEKSEF 1226
Query: 137 KESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEE-------QMAEFYREN 189
K L +V ++ + + A L+ L Q + + +EE + Q A+ EN
Sbjct: 1227 KLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTEN 1286
Query: 190 EEKSKELERQKHMCSVLQH-------KMEELKEGLRQRDELIE---------KHGLVIIP 233
E +++LE ++ + S L +ME+LK L + + +H ++
Sbjct: 1287 GELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLR 1346
Query: 234 DGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQ 293
+ + + ++ + E AQ + E R +L K++L +++ +
Sbjct: 1347 EQYEEETEAKAELQRVLSKANSEVAQ-WRTKYETDAIQRTEELEEAKKKLAQRLQDAEEA 1405
Query: 294 LEEERQKCSRNDGT-------VGDL---AGLQNGSDLQFIEMQRDANRQISEYKFKLSKA 343
+E KCS + T + DL N + + QR+ ++ ++E+K K ++
Sbjct: 1406 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES 1465
Query: 344 EQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTN 403
+ ++ + ++ L ++ + K A E + + + K E + LQ E+ +++ E
Sbjct: 1466 QSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNV 1525
Query: 404 SHLAKRLEKMKANRTAL 420
L K ++++ + L
Sbjct: 1526 HELEKVRKQLEVEKLEL 1542
Score = 54.7 bits (130), Expect = 2e-07
Identities = 82/428 (19%), Positives = 184/428 (42%), Gaps = 41/428 (9%)
Query: 13 VKDRFSAEDEALSNIAREAEARLAAKRA----ARAEARDIRMRELERQQKELDEKSDKQY 68
V+ + E L + EAEA L + A+ E I+ E+ER+ E DE+ + Q
Sbjct: 1531 VRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKA-EIERKLAEKDEEME-QA 1588
Query: 69 AENYTR--PSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSEL-RDIYDLKDQIQDV 125
N+ R S + S A T R L + + LS R + + Q++ +
Sbjct: 1589 KRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSL 1648
Query: 126 EGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIY-QVDTLKDVIEEQEEQMAE 184
+ +L +++ ++ + N + +NNL+ +++ L+ V+E+ E
Sbjct: 1649 QSLLKDTQIQLDDAVRANDD-----LKENIAIVERRNNLLQAELEELRAVVEQTERSRKL 1703
Query: 185 FYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHE 244
+E E S+ ++ + L ++ ++++ L Q +E + + E
Sbjct: 1704 AEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVE--------EAVQECRNAEE 1755
Query: 245 PVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKL-----KLQLEEERQ 299
AIT + A ++ + E L ++ E+ + ++ ++ L+ ++
Sbjct: 1756 KAKKAITDAAMMAEELKK---EQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK 1812
Query: 300 KCSRNDGTVGDLAG---LQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISR 356
+ + + V +L G + + + ++ R + R+I E ++ + ++++ L+ + +
Sbjct: 1813 QLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDK 1872
Query: 357 LEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKAN 416
L+ +V YK AE AE+ + ++ RK+Q EL A ++ + E ++ K++A
Sbjct: 1873 LQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAE-------SQVNKLRAK 1925
Query: 417 RTALLAQQ 424
+ A+Q
Sbjct: 1926 SRDIGAKQ 1933
Score = 52.4 bits (124), Expect = 8e-07
Identities = 59/280 (21%), Positives = 112/280 (40%), Gaps = 59/280 (21%)
Query: 136 LKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKE 195
+KE+L + E + K+ L EKN+L QV +D + + EE+ + + +
Sbjct: 861 IKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQ---- 916
Query: 196 LERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQ 255
L+ K++E+ E L +E+
Sbjct: 917 ----------LEAKVKEMNERLEDEEEM-------------------------------- 934
Query: 256 EAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQ 315
L + RKL E EL I L+L L + ++ + V +L
Sbjct: 935 ----------NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEM 984
Query: 316 NGSD--LQFIEMQRDANRQISEYKFKLSKAEQD-ITTLEQSISRLEGQVLRYKTAAENAE 372
G D + + ++ A ++ + + E+D + +L +S +LE QV + + E +
Sbjct: 985 AGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEK 1044
Query: 373 KVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEK 412
KV +L+ KRKL+ +L+ + I ++E L ++L+K
Sbjct: 1045 KVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKK 1084
Score = 48.5 bits (114), Expect = 1e-05
Identities = 75/308 (24%), Positives = 132/308 (42%), Gaps = 65/308 (21%)
Query: 112 LRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTL 171
L D + DQ+ + + +KE+ E L + EE NA+L +K L + L
Sbjct: 900 LNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEE-------MNAELTAKKRKLEDECSEL 952
Query: 172 KDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVI 231
K I++ E +A ++E++KH ++K++ L E + DE+I K
Sbjct: 953 KKDIDDLELTLA-----------KVEKEKH---ATENKVKNLTEEMAGLDEIIAK----- 993
Query: 232 IPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLK 291
+ +H+ + V + + +S V+L + + E L Q +K++
Sbjct: 994 LTKEKKALQEAHQQALDDLQVEEDKVNSLSKS------KVKLEQQVDDLEGSLEQEKKVR 1047
Query: 292 LQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLE 351
+ LE ++K GDL Q ++++ D Q+ E KL K E DI
Sbjct: 1048 MDLERAKRKLE------GDLKLTQE----SIMDLEND-KLQLEE---KLKKKEFDINQQN 1093
Query: 352 QSISRLEGQVL------RYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSH 405
I + QVL + K E++E+EL+AE RTA K+E++ S
Sbjct: 1094 SKIE--DEQVLALQLQKKLKENQARIEELEEELEAE--------RTARAKVEKL---RSD 1140
Query: 406 LAKRLEKM 413
L++ LE++
Sbjct: 1141 LSRELEEI 1148
Score = 48.5 bits (114), Expect = 1e-05
Identities = 92/471 (19%), Positives = 198/471 (42%), Gaps = 79/471 (16%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAAR--AEARDIRMRELERQQKELDE 62
A+ K + + + DE ++ + +E +A A + A + + ++ L + + +L++
Sbjct: 972 ATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQ 1031
Query: 63 KSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTS----SLIDPDTSLSELR----- 113
+ D R + R+ GD S++D + +L
Sbjct: 1032 QVDDLEGSLEQEKKVRMDLE-------RAKRKLEGDLKLTQESIMDLENDKLQLEEKLKK 1084
Query: 114 ---DIYDLKDQIQDVEGRYMQGLKELKES---LSEVEEKYKKAMVSNAQLDNEKNNLIYQ 167
DI +I+D + +Q K+LKE+ + E+EE+ + + A+++ +++L +
Sbjct: 1085 KEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRE 1144
Query: 168 VDTLKDVIEE--------------QEEQMAEFYRENEEKSKELE------RQKHMCSV-- 205
++ + + +EE +E + + R+ EE + + E R+KH SV
Sbjct: 1145 LEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAE 1204
Query: 206 LQHKMEELKEGLRQRDELIEKHGLVIIPDGTPN------GDVSHEPVAGAITVVSQEAAQ 259
L +++ L+ ++Q+ E + + + D T N + E V+ + + E
Sbjct: 1205 LGEQIDNLQR-VKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRV 1263
Query: 260 VLESAGEGPLDV------------RLRKLAGEKEELLSQIRKLKLQLEEERQKCSR---N 304
LE A D L + EKE L+SQ+ + KL ++ + R
Sbjct: 1264 KLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEE 1323
Query: 305 DGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRY 364
+G + S ++ R+ + +E +KAE L++ +S+ +V ++
Sbjct: 1324 EGKAKNALAHALQSARHDCDLLREQYEEETE-----AKAE-----LQRVLSKANSEVAQW 1373
Query: 365 KTAAE-NAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMK 414
+T E +A + +EL+ K+KL + L+ A + +E + S L K +++
Sbjct: 1374 RTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQ 1424
Score = 38.5 bits (88), Expect = 0.012
Identities = 73/328 (22%), Positives = 137/328 (41%), Gaps = 29/328 (8%)
Query: 107 TSLSELRDIYDLKDQIQDVEGRYMQGLKE----LKESLSEVEEKYKKAMVSNAQLDNEKN 162
T L +L++ Y+ + + R + L+E L E L E + + QL+ EK
Sbjct: 1481 TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKL 1540
Query: 163 NLIYQVDTLKDVIEEQEEQM-----------AEFYRENEEKSKELERQK-HMCSVLQHKM 210
L ++ + +E +E ++ AE R+ EK +E+E+ K + V+
Sbjct: 1541 ELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQ 1600
Query: 211 EELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLD 270
L R R+E++ + +SH A ++ Q L + LD
Sbjct: 1601 TSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLD 1660
Query: 271 VRLRKLAGEKEELLSQIRK---LKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQR 327
+R KE + R+ L+ +LEE R + + + LA + + +++
Sbjct: 1661 DAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERS-RKLAEQELIETSERVQLLH 1719
Query: 328 DANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEK--VEDELKAEKRKL 385
N + K K E D+T L+ S +E V + A E A+K + + AE+ K
Sbjct: 1720 SQNTSLINQK---KKMESDLTQLQ---SEVEEAVQECRNAEEKAKKAITDAAMMAEELKK 1773
Query: 386 QRELRTALDKIEE-MEMTNSHLAKRLEK 412
+++ L+++++ ME T L RL++
Sbjct: 1774 EQDTSAHLERMKKNMEQTIKDLQHRLDE 1801
Score = 33.9 bits (76), Expect = 0.29
Identities = 35/164 (21%), Positives = 78/164 (47%), Gaps = 21/164 (12%)
Query: 270 DVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQF------- 322
+ R ++L + LL + L+LQ++ E+ + + L ++N L+
Sbjct: 869 EARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQL--IKNKIQLEAKVKEMNE 926
Query: 323 -IEMQRDANRQISEYKFKL----SKAEQDITTLEQSISRLEGQVLRYKTAAENA------ 371
+E + + N +++ K KL S+ ++DI LE +++++E + + +N
Sbjct: 927 RLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAG 986
Query: 372 -EKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMK 414
+++ +L EK+ LQ + ALD ++ E + L+K K++
Sbjct: 987 LDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLE 1030
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 60.5 bits (145), Expect = 3e-09
Identities = 80/386 (20%), Positives = 155/386 (40%), Gaps = 56/386 (14%)
Query: 24 LSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNS-AS 82
L + EA +AA R A++ +++ Q+ + +K +K+ +E +S A
Sbjct: 1181 LEEATLQHEAMVAALRKKHADSMAELGEQIDNLQR-VKQKLEKEKSELKMETDDLSSNAE 1239
Query: 83 ATTPLSGNSSRRGSGDTSSLIDPDTSLSE----LRDIYDLKDQIQDVEGRYMQGLKELKE 138
A + GN + + + T E + D+ + ++Q G Y + L E
Sbjct: 1240 AISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDE--- 1296
Query: 139 SLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELER 198
K A+VS QL K Q++ LK +EE+ + + L+
Sbjct: 1297 ---------KDALVS--QLSRSKQASTQQIEELKHQLEEET-------KAKNALAHALQS 1338
Query: 199 QKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEA- 257
+H C +L+ + EE +EG + + K + T +E A T +EA
Sbjct: 1339 SRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRT-----KYETDAIQRTEELEEAK 1393
Query: 258 ---AQVLESAGEG--PLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLA 312
AQ L+ A E ++ + L K+ L +++ L L +E C+ D
Sbjct: 1394 KKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALD------- 1446
Query: 313 GLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAE 372
+ QR+ ++ +SE+K K + + ++ ++ L ++ + K E +
Sbjct: 1447 -----------KKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESL 1495
Query: 373 KVEDELKAEKRKLQRELRTALDKIEE 398
+ L+ E + LQ+E+ ++I E
Sbjct: 1496 DQLETLRRENKNLQQEISDLTEQIAE 1521
Score = 55.8 bits (133), Expect = 7e-08
Identities = 57/260 (21%), Positives = 122/260 (46%), Gaps = 17/260 (6%)
Query: 167 QVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEK 226
++ T+K+ ++ ++++A+ +E K KELE + M ++L+ K + + + D L +
Sbjct: 851 EMATMKEEFQKTKDELAK----SEAKRKELEEK--MVTLLKEKNDLQLQVQSEADSLADA 904
Query: 227 HGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQ 286
+ + E +T ++E ++ L + RKL E EL
Sbjct: 905 EERC---EQLIKNKIQLEAKIKEVTERAEEEEEI-----NAELTAKKRKLEDECSELKKD 956
Query: 287 IRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLS--KAE 344
I L+L L + ++ + V +L G D ++ ++ ++ L +AE
Sbjct: 957 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAE 1016
Query: 345 QD-ITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTN 403
+D + L ++ ++LE QV + + E +K+ +L+ KRKL+ +L+ A + +ME
Sbjct: 1017 EDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDK 1076
Query: 404 SHLAKRLEKMKANRTALLAQ 423
L ++LEK + + L+++
Sbjct: 1077 QQLDEKLEKKEFEISNLISK 1096
Score = 55.1 bits (131), Expect = 1e-07
Identities = 66/320 (20%), Positives = 134/320 (41%), Gaps = 32/320 (10%)
Query: 118 LKDQIQDVEGRYMQGLK---ELKESLSEVEEKYKKAMVSNAQLDNEK------------- 161
L+ Q+ D+EG Q K +L+ + ++E K A S ++N+K
Sbjct: 1030 LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFE 1089
Query: 162 -NNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR 220
+NLI +++ + V + ++++ E EE +E+E ++ + + + +L L +
Sbjct: 1090 ISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEI 1149
Query: 221 DELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAG---EGPLDVRLRKLA 277
E +E+ G G + V A Q+ + LE A E + +K A
Sbjct: 1150 SERLEEAG------GATSAQVELNKKREA---EFQKLRRDLEEATLQHEAMVAALRKKHA 1200
Query: 278 GEKEELLSQI---RKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQIS 334
EL QI +++K +LE+E+ + + A + + +M R Q+S
Sbjct: 1201 DSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVS 1260
Query: 335 EYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALD 394
E K K + ++ I L +RL+ + Y + + + +L K+ +++
Sbjct: 1261 ELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKH 1320
Query: 395 KIEEMEMTNSHLAKRLEKMK 414
++EE + LA L+ +
Sbjct: 1321 QLEEETKAKNALAHALQSSR 1340
Score = 50.1 bits (118), Expect = 4e-06
Identities = 82/437 (18%), Positives = 184/437 (42%), Gaps = 57/437 (13%)
Query: 13 VKDRFSAEDEALSNIAREAEARLAAKRAA----RAEARDIRMRELERQQKELDEKSDKQY 68
+K + E + EAEA L + + E ++ E++R+ E DE+ D Q
Sbjct: 1532 IKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKS-EVDRKIAEKDEEID-QL 1589
Query: 69 AENYTRPSSRNSASATTPLSGNSS-----RRGSGDTSSLIDP--------DTSLSELRDI 115
N+TR ++ + + ++ GD + + SL R+
Sbjct: 1590 KRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNT 1649
Query: 116 YDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVI 175
+ + Q ++G ++LKE L+ VE ++A + A+++ E + Q + + +
Sbjct: 1650 QGILKETQLHLDDALRGQEDLKEQLAIVE---RRANLLQAEIE-ELWATLEQTERSRKIA 1705
Query: 176 EEQ----EEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVI 231
E++ E++ + +N ++ ++ S LQ ++EE+ + R +E +K
Sbjct: 1706 EQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKK----A 1761
Query: 232 IPDGTPNGDV--SHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEE---LLSQ 286
I D + + + + + + Q ++ + L G K++ L ++
Sbjct: 1762 ITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEAR 1821
Query: 287 IRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQD 346
+R+L+ ++E E+++ + + ++ R R++ E ++ + ++
Sbjct: 1822 VRELEGEVENEQKR------------------NAEAVKGLRKHERRVKELTYQTEEDRKN 1863
Query: 347 ITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHL 406
+ L+ + +L+ +V YK AE AE+ + ++ RKLQ EL A E ++ S +
Sbjct: 1864 VLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEA---EERADIAESQV 1920
Query: 407 AKRLEKMKANRTALLAQ 423
K K + T + A+
Sbjct: 1921 NKLRVKSREVHTKISAE 1937
Score = 49.7 bits (117), Expect = 5e-06
Identities = 91/477 (19%), Positives = 197/477 (41%), Gaps = 91/477 (19%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAA----RAEARDIRM-----RELER 55
A+ K + + + DE ++ +++E +A + +AE + + +LE+
Sbjct: 973 ATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQ 1032
Query: 56 QQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELR-D 114
Q +L+ +++ ++ L+ S+ D L D L + +
Sbjct: 1033 QVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQL---DEKLEKKEFE 1089
Query: 115 IYDLKDQIQDVEGRYMQGLKELKESLSEVE---EKYKKAMVSNAQLDNEKNNLIYQVDTL 171
I +L +I+D + +Q K++KE + +E E+ + S A+ + ++++L +++ +
Sbjct: 1090 ISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEI 1149
Query: 172 KDVIEE--------------QEEQMAEFYRENEEKSKELE------RQKHMCSV------ 205
+ +EE +E + + R+ EE + + E R+KH S+
Sbjct: 1150 SERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQ 1209
Query: 206 ------LQHKMEELKEGLRQRDELIEKHGLVI-------------IPDGTPNGDVSHEPV 246
++ K+E+ K L+ + + + I + D E
Sbjct: 1210 IDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQ 1269
Query: 247 AGAITVVSQEAAQVLESAGE-----GPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKC 301
I ++ + A++ AGE D + +L+ K+ QI +LK QLEEE +
Sbjct: 1270 QRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETK-- 1327
Query: 302 SRNDGTVGDLAGLQNGSDL---QFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLE 358
+ L ++ DL Q+ E Q KAE L++++S+
Sbjct: 1328 -AKNALAHALQSSRHDCDLLREQYEEEQE-------------GKAE-----LQRALSKAN 1368
Query: 359 GQVLRYKTAAE-NAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMK 414
+V +++T E +A + +EL+ K+KL + L+ A + +E + + L K ++++
Sbjct: 1369 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQ 1425
Score = 46.2 bits (108), Expect = 6e-05
Identities = 57/289 (19%), Positives = 129/289 (44%), Gaps = 39/289 (13%)
Query: 134 KELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYREN---E 190
++ K+ L++ E K K+ L EKN+L QV + D + + EE+ + + E
Sbjct: 860 QKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLE 919
Query: 191 EKSKEL----ERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPV 246
K KE+ E ++ + + L K +L++ + + I+ L +
Sbjct: 920 AKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK------------- 966
Query: 247 AGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDG 306
V +E + A E + ++AG +E ++++ K K L+E Q+
Sbjct: 967 ------VEKE-----KHATENKVKNLTEEMAG-LDETIAKLSKEKKALQETHQQ------ 1008
Query: 307 TVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKT 366
T+ DL ++ ++ + + +Q+ + + L + ++ LE++ +LEG + +
Sbjct: 1009 TLDDLQAEEDKVNI-LTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQE 1067
Query: 367 AAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKA 415
+ + E + +L + K + E+ + KIE+ + L K++++++A
Sbjct: 1068 STMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQA 1116
Score = 45.8 bits (107), Expect = 7e-05
Identities = 85/435 (19%), Positives = 176/435 (40%), Gaps = 61/435 (14%)
Query: 13 VKDRFSAEDEALSNIAR---EAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYA 69
+++++ E E + + R +A + +A R R ELE +K+L ++ Q A
Sbjct: 1346 LREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL--QEA 1403
Query: 70 ENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRY 129
E + + AS L R + ++D + S + + D+ Q
Sbjct: 1404 EEHVEAVNAKCAS----LEKTKQRLQNEVEDLMLDVERSNAACAAL----DKKQ------ 1449
Query: 130 MQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYREN 189
+ + LSE ++KY++ E +L ++ +K+V EE +Q+ REN
Sbjct: 1450 ----RNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRREN 1505
Query: 190 ---EEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPV 246
+++ +L Q H++E++K+ + Q E E I + S E
Sbjct: 1506 KNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQ--EKCE------IQAALEEAEASLEHE 1557
Query: 247 AGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKC----- 301
G I + E QV RK+A EK+E + Q+++ ++ E Q
Sbjct: 1558 EGKILRIQLELNQVKSEVD--------RKIA-EKDEEIDQLKRNHTRVVETMQSTLDAEI 1608
Query: 302 -SRNDG------TVGDLAGLQ------NGSDLQFIEMQRDANRQISEYKFKLSKAEQDIT 348
SRND GDL ++ N + + R+ + E + L A +
Sbjct: 1609 RSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQE 1668
Query: 349 TLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAK 408
L++ ++ +E + + E ++ + ++ ++EL A ++++ + N+ L
Sbjct: 1669 DLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLIN 1728
Query: 409 RLEKMKANRTALLAQ 423
+K++ + + L ++
Sbjct: 1729 TKKKLENDVSQLQSE 1743
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 60.1 bits (144), Expect = 4e-09
Identities = 89/434 (20%), Positives = 180/434 (41%), Gaps = 25/434 (5%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDE-K 63
A R+ +R + + S R+AE LA++ A AEA RE +R + L+E +
Sbjct: 1487 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA----AREKQRALQALEELR 1542
Query: 64 SDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGD----TSSLIDPDTSLS-ELRDIYDL 118
+ AE R + A + R + +S + L L++ +
Sbjct: 1543 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1602
Query: 119 KDQIQDVEGRYMQGLKELKESLSEVE---EKYKKAMVSNAQLDNEKNNLIYQVDTLKDVI 175
Q+++ R Q E + + E E E+++ +L + + Q +
Sbjct: 1603 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1662
Query: 176 EEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDG 235
E+Q+E+ R + ++ RQ+ + K +L EG Q+ L + L+ +
Sbjct: 1663 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-RLAAEQELIRLRAE 1721
Query: 236 TPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQ-- 293
T G+ + + + + +EAA + E L+ L K+ E E LL+ + + +
Sbjct: 1722 TEQGEQQRQLLEEELARLQREAAAATQKRQE--LEAELAKVRAEMEVLLASKARAEEESR 1779
Query: 294 --LEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLE 351
E+ +Q+ G +LA + + L+ + + RQ++E +AE + L
Sbjct: 1780 STSEKSKQRLEAEAGRFRELA--EEAARLRALAEEAKRQRQLAEEDAARQRAEAE-RVLA 1836
Query: 352 QSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTN-SHLAKRL 410
+ ++ + G+ R KT AE A K ++ R+L + ++EE + + + +RL
Sbjct: 1837 EKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895
Query: 411 EKMKANRTALLAQQ 424
+++ + L +Q
Sbjct: 1896 AQLRKASDSELERQ 1909
Score = 58.9 bits (141), Expect = 8e-09
Identities = 91/445 (20%), Positives = 173/445 (38%), Gaps = 64/445 (14%)
Query: 19 AEDEALSNIAREAEARLAAKRAARAEARDIRMR-----ELERQQKELDEKSDKQYAENYT 73
AEDEA E +A A+ A E R ++R ELERQ+ +++ T
Sbjct: 1870 AEDEAFQRRRLEEQA---AQHKADIEERLAQLRKASDSELERQKGLVED----------T 1916
Query: 74 RPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGL 133
R L + + +G ++ S D K+Q + R Q
Sbjct: 1917 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1976
Query: 134 KELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEE----------QEEQMA 183
E + E EE+ +K++ + + ++ + +V+ LK +EE + +
Sbjct: 1977 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2036
Query: 184 EFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSH 243
+ +E +K + E + H +V Q K +EL++ L+Q ++++ + +
Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAV-QQKEQELQQTLQQEQSVLDQ-----LRGEAEAARRAA 2090
Query: 244 EPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKL--KLQLEEERQKC 301
E A +EAAQ E RL++ A E+ + +Q + KL+ E E++
Sbjct: 2091 EEAEEARVQAEREAAQSRRQVEEAE---RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2147
Query: 302 SRNDGTVGDLAGLQNGS---------DLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQ 352
R L Q Q + + ++++ + +L + + L++
Sbjct: 2148 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2207
Query: 353 SISRLEGQVLRYKTAAENAEKVEDEL--------KAEKRKLQRELRTALDKIEEMEMTNS 404
+ RL+ + AA +VE+EL + K K + E + + + T
Sbjct: 2208 ELQRLKAEATE---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 405 HLAKRLEKMK-----ANRTALLAQQ 424
L + EKMK A R ++ AQ+
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQE 2289
Score = 55.8 bits (133), Expect = 7e-08
Identities = 97/458 (21%), Positives = 187/458 (40%), Gaps = 79/458 (17%)
Query: 13 VKDRFSAEDEALSNIAREAE-ARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAEN 71
V D+ E EA A EAE AR+ A+R A R + E ER ++ +E++ +
Sbjct: 2075 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARAQAQ 2132
Query: 72 YTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQ 131
R A ++RR + ++L + +E+ +Q + + Q
Sbjct: 2133 AAAEKLRKEAEQ------EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2186
Query: 132 GLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEE 191
L L+ L E D++KN L ++ LK E Q ++ EE
Sbjct: 2187 ELTTLRLQLEET--------------DHQKNLLDEELQRLKAEATEAARQRSQV----EE 2228
Query: 192 KSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAIT 251
+ + Q S L+ ++E L RD+ + + + V+ E A ++
Sbjct: 2229 ELFSVRVQMEELSKLKARIEAENRALILRDK--DNTQRFLQEEAEKMKQVAEE--AARLS 2284
Query: 252 VVSQEAAQVLESAGEGPLDVRL--RKLAGEKEELLSQIRKLKLQ---------------- 293
V +QEAA++ + A E R K+ EK + + + +LK +
Sbjct: 2285 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2344
Query: 294 -LEEERQKCSRN--DGTVGDLAGLQNGSDLQFIEMQRDANR---QISEYKFKLSKAEQDI 347
L+E++++ ++ + T G L+ Q +EM +A R +++E ++AE+D
Sbjct: 2345 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKLRVAEMSRAQARAEEDA 2403
Query: 348 TTLEQSISRLEGQVLRYKTAAE------------------NAEKVED---ELKAEKRKLQ 386
+ + ++ R + A + +AE++ + EL+ EK KLQ
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2463
Query: 387 RELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 424
+E + K EEM+ + L++ +A + + L+++
Sbjct: 2464 QEAKLLQLKSEEMQTVQQE--QLLQETQALQQSFLSEK 2499
Score = 54.3 bits (129), Expect = 2e-07
Identities = 83/428 (19%), Positives = 172/428 (40%), Gaps = 43/428 (10%)
Query: 7 GRKRTPVKDRFSAEDEALSNIAR-------------EAEARLAAKRAARAEA---RDIRM 50
GR R+ +D ++++A AR EAE R+ AA EA R +
Sbjct: 1949 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008
Query: 51 RELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLS 110
E+ER + +++E ++ E + S+R A ++ + L
Sbjct: 2009 EEVERLKAKVEEA--RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2066
Query: 111 E-LRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVD 169
+ L+ + DQ++ + +E +E+ + E ++A S Q++ + +
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE---REAAQSRRQVE--------EAE 2115
Query: 170 TLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR---DELIEK 226
LK EEQ + A+ E+ KE E++ + + + LRQ+ D +EK
Sbjct: 2116 RLKQSAEEQAQARAQAQAAAEKLRKEAEQE------AARRAQAEQAALRQKQAADAEMEK 2169
Query: 227 HGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQ 286
H V E + + + + L L + A ++ ++ +
Sbjct: 2170 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2229
Query: 287 IRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQD 346
+ +++Q+EE + +R + L + +F++ + + +Q++E +LS A Q+
Sbjct: 2230 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2289
Query: 347 ITTLEQSISR--LEGQVLRYKTAAENAEKVED--ELKAEKRKLQRELRTALDKIEEMEMT 402
L Q + + L K E + V++ LKAE LQ++ A ++ ++
Sbjct: 2290 AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2349
Query: 403 NSHLAKRL 410
+A++L
Sbjct: 2350 KEQMAQQL 2357
Score = 53.5 bits (127), Expect = 4e-07
Identities = 90/445 (20%), Positives = 180/445 (40%), Gaps = 54/445 (12%)
Query: 8 RKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELE----RQQKELDEK 63
++R ++R + + AL + AEA AK A EA++++ R E R++ +D +
Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1412
Query: 64 SDKQYAENYTRPSSRNS-----ASATTPLSGNSSRRGSGDTSSLIDPDTSLSELR----- 113
K+ + + ++S A A + SR + ++ +E +
Sbjct: 1413 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1472
Query: 114 -DIYDLKDQIQDVEGRYMQGLKE---LKESLSEVEEKYKKAMV-------SNAQLDNEKN 162
++ L+ + ++ E + Q +E L+ + + ++ ++A V + A+ EK
Sbjct: 1473 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532
Query: 163 NLIYQVDTLKDVIEEQEEQM--AEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR 220
+ ++ L+ EE E ++ AE R + + Q+ + LQ K E Q
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592
Query: 221 DE-LIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGE 279
+ L E+H V + A ++ + + L +RL+
Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1652
Query: 280 KEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFK 339
+++ L+Q K + E ER+ +R G + A Q + E + + RQ++E
Sbjct: 1653 QQKSLAQAEAEKQKEEAERE--ARRRGKAEEQAVRQR----ELAEQELEKQRQLAE---- 1702
Query: 340 LSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEM 399
T +Q ++ E +++R + E E+ L+ E +LQRE A K +E+
Sbjct: 1703 --------GTAQQRLAA-EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 400 EMTNSHLAKRLEKMKANRTALLAQQ 424
E L K++A LLA +
Sbjct: 1754 E-------AELAKVRAEMEVLLASK 1771
Score = 50.8 bits (120), Expect = 2e-06
Identities = 92/442 (20%), Positives = 156/442 (35%), Gaps = 39/442 (8%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKS 64
AS ++T +R E+ RE R A ++A AR+ RELER Q + +E
Sbjct: 1583 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1642
Query: 65 D-KQYAENYTRPSSRNSASA---TTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKD 120
+ AE + S A A + RRG + ++ + + EL L +
Sbjct: 1643 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1702
Query: 121 QIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLK----DVIE 176
Q L L+ + E++ + A+L E + L+ V
Sbjct: 1703 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1762
Query: 177 EQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGT 236
E E +A R EE E+ K + EL E + L E +
Sbjct: 1763 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE--------EAK 1814
Query: 237 PNGDVSHEPVAGAITVVSQEAAQVLESAGEG-----PLDVRLRKLAGEKEELLSQIRKLK 291
++ E A + A+ L + GE ++ L++ E E L
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 292 LQLEEERQKCSRNDGTVGD-LAGLQNGSDLQF----------IEMQRDANRQISEYKFKL 340
Q ++ +++ + + LA L+ SD + + +R +I K
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1934
Query: 341 SKAEQDITTLEQSISRLEG---QVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKI- 396
KA LE + R+ LR K AE + +L AE+ + +RE + K
Sbjct: 1935 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1994
Query: 397 ---EEMEMTNSHLAKRLEKMKA 415
EE + +E++KA
Sbjct: 1995 AAEEEAARQRKAALEEVERLKA 2016
Score = 43.1 bits (100), Expect = 5e-04
Identities = 87/429 (20%), Positives = 172/429 (40%), Gaps = 51/429 (11%)
Query: 29 REAEARLAAKRAARAEARDIRMRELE---RQQKELDEKSDK--QYAENYTRPSSRNSASA 83
RE A+L + A D+R RELE RQ + E +D + ++ R R
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR---RQEQIQ 1234
Query: 84 TTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKE-------L 136
PL+ + + R L L E+ + ++ Q +Y+ +K+
Sbjct: 1235 AMPLADSQAVR-----EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1289
Query: 137 KESLSEVEEKYKKAMVSNA--QLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSK 194
K L V KK V + + E +L L + + + ++E R EE+ +
Sbjct: 1290 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349
Query: 195 ELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGD----VSHEPVAGAI 250
E+Q+ + + ++ E++ L ++ +L E H + + E V
Sbjct: 1350 LAEQQR---AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1406
Query: 251 TVVS--------QEAAQVLESAGEGPLDVRLRKL-AGEKEELL--SQIRKLKLQLEEERQ 299
V QE Q L + E + + R+ A E+ L +IR ++LQLE +
Sbjct: 1407 AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1466
Query: 300 KCSRNDGTVGDLAGLQNGSDLQFIEMQRDA---NRQISEYKFKLSKAEQDITTLEQSISR 356
+ +G + L ++ Q + Q +A RQ+ + + +AE ++ S +
Sbjct: 1467 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA----SRVK 1522
Query: 357 LEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTA-LDKIEEMEMTNSHLAKRLEKMKA 415
E + R K + A + +EL+ + + +R LR A +++ ++++ + E
Sbjct: 1523 AEAEAAREK---QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1579
Query: 416 NRTALLAQQ 424
++ A A++
Sbjct: 1580 SKRASFAEK 1588
Score = 34.7 bits (78), Expect = 0.17
Identities = 42/221 (19%), Positives = 92/221 (41%), Gaps = 28/221 (12%)
Query: 30 EAEARLAAKRAARAEARDIRMRELERQQKELDE------KSDKQYAENYTRPSSRNSASA 83
EAE + + +A AE +R+ E+ R Q +E K ++ E R
Sbjct: 2369 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2428
Query: 84 TTPLSGNSSRRGSG-DTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSE 142
T + R+ S D L + L ++ + ++ ++ MQ +++ E L +
Sbjct: 2429 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQLLQ 2486
Query: 143 VEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSK---ELERQ 199
+ +++ +S ++ I Q + + + E A+ RE +++ + E ERQ
Sbjct: 2487 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2546
Query: 200 KHMCSV----------------LQHKMEELKEGLRQRDELI 224
+ + S+ Q ++++L++ RQ++EL+
Sbjct: 2547 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2587
Score = 31.6 bits (70), Expect = 1.4
Identities = 52/273 (19%), Positives = 115/273 (42%), Gaps = 28/273 (10%)
Query: 48 IRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDT 107
++ E++RQQ + D + ++ R + A L S + L+
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL-LQLKSEEMQTVQQEQLLQETQ 2489
Query: 108 SLSELRDIYDLKDQIQDVEGRYMQGLKELKESL-----SEVEEKYKKAMVSNAQLDNEKN 162
+L + KD + E R+++ K E L ++ ++ ++ Q++ E+
Sbjct: 2490 ALQQ--SFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2546
Query: 163 NLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDE 222
L+ ++ + E EE + R +E+ ++LE+Q+ L + E + LR++ +
Sbjct: 2547 RLVASMEEARRRQHEAEEGV----RRKQEELQQLEQQRRQQEEL---LAEENQRLREQLQ 2599
Query: 223 LIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAA---QVLESAGEGPLDVRLRKLAGE 279
L+E+ + + +V+ VA T+ + A E+ E D RK++ +
Sbjct: 2600 LLEEQHRAAL---AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQ 2656
Query: 280 KEELLSQIRKLKLQLEEERQKCSRNDGTVGDLA 312
+ +++ + EE Q+ ++ TV +LA
Sbjct: 2657 R------LQEAGILSAEELQRLAQGHTTVDELA 2683
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 60.1 bits (144), Expect = 4e-09
Identities = 89/434 (20%), Positives = 180/434 (41%), Gaps = 25/434 (5%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDE-K 63
A R+ +R + + S R+AE LA++ A AEA RE +R + L+E +
Sbjct: 1491 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA----AREKQRALQALEELR 1546
Query: 64 SDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGD----TSSLIDPDTSLS-ELRDIYDL 118
+ AE R + A + R + +S + L L++ +
Sbjct: 1547 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1606
Query: 119 KDQIQDVEGRYMQGLKELKESLSEVE---EKYKKAMVSNAQLDNEKNNLIYQVDTLKDVI 175
Q+++ R Q E + + E E E+++ +L + + Q +
Sbjct: 1607 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1666
Query: 176 EEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDG 235
E+Q+E+ R + ++ RQ+ + K +L EG Q+ L + L+ +
Sbjct: 1667 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-RLAAEQELIRLRAE 1725
Query: 236 TPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQ-- 293
T G+ + + + + +EAA + E L+ L K+ E E LL+ + + +
Sbjct: 1726 TEQGEQQRQLLEEELARLQREAAAATQKRQE--LEAELAKVRAEMEVLLASKARAEEESR 1783
Query: 294 --LEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLE 351
E+ +Q+ G +LA + + L+ + + RQ++E +AE + L
Sbjct: 1784 STSEKSKQRLEAEAGRFRELA--EEAARLRALAEEAKRQRQLAEEDAARQRAEAE-RVLA 1840
Query: 352 QSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTN-SHLAKRL 410
+ ++ + G+ R KT AE A K ++ R+L + ++EE + + + +RL
Sbjct: 1841 EKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1899
Query: 411 EKMKANRTALLAQQ 424
+++ + L +Q
Sbjct: 1900 AQLRKASDSELERQ 1913
Score = 58.9 bits (141), Expect = 8e-09
Identities = 91/445 (20%), Positives = 173/445 (38%), Gaps = 64/445 (14%)
Query: 19 AEDEALSNIAREAEARLAAKRAARAEARDIRMR-----ELERQQKELDEKSDKQYAENYT 73
AEDEA E +A A+ A E R ++R ELERQ+ +++ T
Sbjct: 1874 AEDEAFQRRRLEEQA---AQHKADIEERLAQLRKASDSELERQKGLVED----------T 1920
Query: 74 RPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGL 133
R L + + +G ++ S D K+Q + R Q
Sbjct: 1921 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1980
Query: 134 KELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEE----------QEEQMA 183
E + E EE+ +K++ + + ++ + +V+ LK +EE + +
Sbjct: 1981 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2040
Query: 184 EFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSH 243
+ +E +K + E + H +V Q K +EL++ L+Q ++++ + +
Sbjct: 2041 QLAQEAAQKRLQAEEKAHAFAV-QQKEQELQQTLQQEQSVLDQ-----LRGEAEAARRAA 2094
Query: 244 EPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKL--KLQLEEERQKC 301
E A +EAAQ E RL++ A E+ + +Q + KL+ E E++
Sbjct: 2095 EEAEEARVQAEREAAQSRRQVEEAE---RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2151
Query: 302 SRNDGTVGDLAGLQNGS---------DLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQ 352
R L Q Q + + ++++ + +L + + L++
Sbjct: 2152 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2211
Query: 353 SISRLEGQVLRYKTAAENAEKVEDEL--------KAEKRKLQRELRTALDKIEEMEMTNS 404
+ RL+ + AA +VE+EL + K K + E + + + T
Sbjct: 2212 ELQRLKAEATE---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2268
Query: 405 HLAKRLEKMK-----ANRTALLAQQ 424
L + EKMK A R ++ AQ+
Sbjct: 2269 FLQEEAEKMKQVAEEAARLSVAAQE 2293
Score = 55.8 bits (133), Expect = 7e-08
Identities = 97/458 (21%), Positives = 187/458 (40%), Gaps = 79/458 (17%)
Query: 13 VKDRFSAEDEALSNIAREAE-ARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAEN 71
V D+ E EA A EAE AR+ A+R A R + E ER ++ +E++ +
Sbjct: 2079 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARAQAQ 2136
Query: 72 YTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQ 131
R A ++RR + ++L + +E+ +Q + + Q
Sbjct: 2137 AAAEKLRKEAEQ------EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2190
Query: 132 GLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEE 191
L L+ L E D++KN L ++ LK E Q ++ EE
Sbjct: 2191 ELTTLRLQLEET--------------DHQKNLLDEELQRLKAEATEAARQRSQV----EE 2232
Query: 192 KSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAIT 251
+ + Q S L+ ++E L RD+ + + + V+ E A ++
Sbjct: 2233 ELFSVRVQMEELSKLKARIEAENRALILRDK--DNTQRFLQEEAEKMKQVAEE--AARLS 2288
Query: 252 VVSQEAAQVLESAGEGPLDVRL--RKLAGEKEELLSQIRKLKLQ---------------- 293
V +QEAA++ + A E R K+ EK + + + +LK +
Sbjct: 2289 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2348
Query: 294 -LEEERQKCSRN--DGTVGDLAGLQNGSDLQFIEMQRDANR---QISEYKFKLSKAEQDI 347
L+E++++ ++ + T G L+ Q +EM +A R +++E ++AE+D
Sbjct: 2349 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKLRVAEMSRAQARAEEDA 2407
Query: 348 TTLEQSISRLEGQVLRYKTAAE------------------NAEKVED---ELKAEKRKLQ 386
+ + ++ R + A + +AE++ + EL+ EK KLQ
Sbjct: 2408 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2467
Query: 387 RELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 424
+E + K EEM+ + L++ +A + + L+++
Sbjct: 2468 QEAKLLQLKSEEMQTVQQE--QLLQETQALQQSFLSEK 2503
Score = 54.3 bits (129), Expect = 2e-07
Identities = 83/428 (19%), Positives = 172/428 (40%), Gaps = 43/428 (10%)
Query: 7 GRKRTPVKDRFSAEDEALSNIAR-------------EAEARLAAKRAARAEA---RDIRM 50
GR R+ +D ++++A AR EAE R+ AA EA R +
Sbjct: 1953 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2012
Query: 51 RELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLS 110
E+ER + +++E ++ E + S+R A ++ + L
Sbjct: 2013 EEVERLKAKVEEA--RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2070
Query: 111 E-LRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVD 169
+ L+ + DQ++ + +E +E+ + E ++A S Q++ + +
Sbjct: 2071 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE---REAAQSRRQVE--------EAE 2119
Query: 170 TLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR---DELIEK 226
LK EEQ + A+ E+ KE E++ + + + LRQ+ D +EK
Sbjct: 2120 RLKQSAEEQAQARAQAQAAAEKLRKEAEQE------AARRAQAEQAALRQKQAADAEMEK 2173
Query: 227 HGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQ 286
H V E + + + + L L + A ++ ++ +
Sbjct: 2174 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2233
Query: 287 IRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQD 346
+ +++Q+EE + +R + L + +F++ + + +Q++E +LS A Q+
Sbjct: 2234 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2293
Query: 347 ITTLEQSISR--LEGQVLRYKTAAENAEKVED--ELKAEKRKLQRELRTALDKIEEMEMT 402
L Q + + L K E + V++ LKAE LQ++ A ++ ++
Sbjct: 2294 AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2353
Query: 403 NSHLAKRL 410
+A++L
Sbjct: 2354 KEQMAQQL 2361
Score = 53.5 bits (127), Expect = 4e-07
Identities = 90/445 (20%), Positives = 180/445 (40%), Gaps = 54/445 (12%)
Query: 8 RKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELE----RQQKELDEK 63
++R ++R + + AL + AEA AK A EA++++ R E R++ +D +
Sbjct: 1357 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1416
Query: 64 SDKQYAENYTRPSSRNS-----ASATTPLSGNSSRRGSGDTSSLIDPDTSLSELR----- 113
K+ + + ++S A A + SR + ++ +E +
Sbjct: 1417 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1476
Query: 114 -DIYDLKDQIQDVEGRYMQGLKE---LKESLSEVEEKYKKAMV-------SNAQLDNEKN 162
++ L+ + ++ E + Q +E L+ + + ++ ++A V + A+ EK
Sbjct: 1477 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1536
Query: 163 NLIYQVDTLKDVIEEQEEQM--AEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR 220
+ ++ L+ EE E ++ AE R + + Q+ + LQ K E Q
Sbjct: 1537 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1596
Query: 221 DE-LIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGE 279
+ L E+H V + A ++ + + L +RL+
Sbjct: 1597 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1656
Query: 280 KEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFK 339
+++ L+Q K + E ER+ +R G + A Q + E + + RQ++E
Sbjct: 1657 QQKSLAQAEAEKQKEEAERE--ARRRGKAEEQAVRQR----ELAEQELEKQRQLAE---- 1706
Query: 340 LSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEM 399
T +Q ++ E +++R + E E+ L+ E +LQRE A K +E+
Sbjct: 1707 --------GTAQQRLAA-EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1757
Query: 400 EMTNSHLAKRLEKMKANRTALLAQQ 424
E L K++A LLA +
Sbjct: 1758 E-------AELAKVRAEMEVLLASK 1775
Score = 50.8 bits (120), Expect = 2e-06
Identities = 92/442 (20%), Positives = 156/442 (35%), Gaps = 39/442 (8%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKS 64
AS ++T +R E+ RE R A ++A AR+ RELER Q + +E
Sbjct: 1587 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1646
Query: 65 D-KQYAENYTRPSSRNSASA---TTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKD 120
+ AE + S A A + RRG + ++ + + EL L +
Sbjct: 1647 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1706
Query: 121 QIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLK----DVIE 176
Q L L+ + E++ + A+L E + L+ V
Sbjct: 1707 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1766
Query: 177 EQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGT 236
E E +A R EE E+ K + EL E + L E +
Sbjct: 1767 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE--------EAK 1818
Query: 237 PNGDVSHEPVAGAITVVSQEAAQVLESAGEG-----PLDVRLRKLAGEKEELLSQIRKLK 291
++ E A + A+ L + GE ++ L++ E E L
Sbjct: 1819 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1878
Query: 292 LQLEEERQKCSRNDGTVGD-LAGLQNGSDLQF----------IEMQRDANRQISEYKFKL 340
Q ++ +++ + + LA L+ SD + + +R +I K
Sbjct: 1879 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1938
Query: 341 SKAEQDITTLEQSISRLEG---QVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKI- 396
KA LE + R+ LR K AE + +L AE+ + +RE + K
Sbjct: 1939 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1998
Query: 397 ---EEMEMTNSHLAKRLEKMKA 415
EE + +E++KA
Sbjct: 1999 AAEEEAARQRKAALEEVERLKA 2020
Score = 43.1 bits (100), Expect = 5e-04
Identities = 87/429 (20%), Positives = 172/429 (40%), Gaps = 51/429 (11%)
Query: 29 REAEARLAAKRAARAEARDIRMRELE---RQQKELDEKSDK--QYAENYTRPSSRNSASA 83
RE A+L + A D+R RELE RQ + E +D + ++ R R
Sbjct: 1182 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR---RQEQIQ 1238
Query: 84 TTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKE-------L 136
PL+ + + R L L E+ + ++ Q +Y+ +K+
Sbjct: 1239 AMPLADSQAVR-----EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1293
Query: 137 KESLSEVEEKYKKAMVSNA--QLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSK 194
K L V KK V + + E +L L + + + ++E R EE+ +
Sbjct: 1294 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1353
Query: 195 ELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGD----VSHEPVAGAI 250
E+Q+ + + ++ E++ L ++ +L E H + + E V
Sbjct: 1354 LAEQQR---AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1410
Query: 251 TVVS--------QEAAQVLESAGEGPLDVRLRKL-AGEKEELL--SQIRKLKLQLEEERQ 299
V QE Q L + E + + R+ A E+ L +IR ++LQLE +
Sbjct: 1411 AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1470
Query: 300 KCSRNDGTVGDLAGLQNGSDLQFIEMQRDA---NRQISEYKFKLSKAEQDITTLEQSISR 356
+ +G + L ++ Q + Q +A RQ+ + + +AE ++ S +
Sbjct: 1471 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA----SRVK 1526
Query: 357 LEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTA-LDKIEEMEMTNSHLAKRLEKMKA 415
E + R K + A + +EL+ + + +R LR A +++ ++++ + E
Sbjct: 1527 AEAEAAREK---QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1583
Query: 416 NRTALLAQQ 424
++ A A++
Sbjct: 1584 SKRASFAEK 1592
Score = 34.7 bits (78), Expect = 0.17
Identities = 42/221 (19%), Positives = 92/221 (41%), Gaps = 28/221 (12%)
Query: 30 EAEARLAAKRAARAEARDIRMRELERQQKELDE------KSDKQYAENYTRPSSRNSASA 83
EAE + + +A AE +R+ E+ R Q +E K ++ E R
Sbjct: 2373 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2432
Query: 84 TTPLSGNSSRRGSG-DTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSE 142
T + R+ S D L + L ++ + ++ ++ MQ +++ E L +
Sbjct: 2433 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQLLQ 2490
Query: 143 VEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSK---ELERQ 199
+ +++ +S ++ I Q + + + E A+ RE +++ + E ERQ
Sbjct: 2491 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2550
Query: 200 KHMCSV----------------LQHKMEELKEGLRQRDELI 224
+ + S+ Q ++++L++ RQ++EL+
Sbjct: 2551 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2591
Score = 31.6 bits (70), Expect = 1.4
Identities = 52/273 (19%), Positives = 115/273 (42%), Gaps = 28/273 (10%)
Query: 48 IRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDT 107
++ E++RQQ + D + ++ R + A L S + L+
Sbjct: 2435 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL-LQLKSEEMQTVQQEQLLQETQ 2493
Query: 108 SLSELRDIYDLKDQIQDVEGRYMQGLKELKESL-----SEVEEKYKKAMVSNAQLDNEKN 162
+L + KD + E R+++ K E L ++ ++ ++ Q++ E+
Sbjct: 2494 ALQQ--SFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2550
Query: 163 NLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDE 222
L+ ++ + E EE + R +E+ ++LE+Q+ L + E + LR++ +
Sbjct: 2551 RLVASMEEARRRQHEAEEGV----RRKQEELQQLEQQRRQQEEL---LAEENQRLREQLQ 2603
Query: 223 LIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAA---QVLESAGEGPLDVRLRKLAGE 279
L+E+ + + +V+ VA T+ + A E+ E D RK++ +
Sbjct: 2604 LLEEQHRAAL---AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQ 2660
Query: 280 KEELLSQIRKLKLQLEEERQKCSRNDGTVGDLA 312
+ +++ + EE Q+ ++ TV +LA
Sbjct: 2661 R------LQEAGILSAEELQRLAQGHTTVDELA 2687
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 60.1 bits (144), Expect = 4e-09
Identities = 89/434 (20%), Positives = 180/434 (41%), Gaps = 25/434 (5%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDE-K 63
A R+ +R + + S R+AE LA++ A AEA RE +R + L+E +
Sbjct: 1487 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA----AREKQRALQALEELR 1542
Query: 64 SDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGD----TSSLIDPDTSLS-ELRDIYDL 118
+ AE R + A + R + +S + L L++ +
Sbjct: 1543 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1602
Query: 119 KDQIQDVEGRYMQGLKELKESLSEVE---EKYKKAMVSNAQLDNEKNNLIYQVDTLKDVI 175
Q+++ R Q E + + E E E+++ +L + + Q +
Sbjct: 1603 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1662
Query: 176 EEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDG 235
E+Q+E+ R + ++ RQ+ + K +L EG Q+ L + L+ +
Sbjct: 1663 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-RLAAEQELIRLRAE 1721
Query: 236 TPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQ-- 293
T G+ + + + + +EAA + E L+ L K+ E E LL+ + + +
Sbjct: 1722 TEQGEQQRQLLEEELARLQREAAAATQKRQE--LEAELAKVRAEMEVLLASKARAEEESR 1779
Query: 294 --LEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLE 351
E+ +Q+ G +LA + + L+ + + RQ++E +AE + L
Sbjct: 1780 STSEKSKQRLEAEAGRFRELA--EEAARLRALAEEAKRQRQLAEEDAARQRAEAE-RVLA 1836
Query: 352 QSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTN-SHLAKRL 410
+ ++ + G+ R KT AE A K ++ R+L + ++EE + + + +RL
Sbjct: 1837 EKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895
Query: 411 EKMKANRTALLAQQ 424
+++ + L +Q
Sbjct: 1896 AQLRKASDSELERQ 1909
Score = 58.9 bits (141), Expect = 8e-09
Identities = 91/445 (20%), Positives = 173/445 (38%), Gaps = 64/445 (14%)
Query: 19 AEDEALSNIAREAEARLAAKRAARAEARDIRMR-----ELERQQKELDEKSDKQYAENYT 73
AEDEA E +A A+ A E R ++R ELERQ+ +++ T
Sbjct: 1870 AEDEAFQRRRLEEQA---AQHKADIEERLAQLRKASDSELERQKGLVED----------T 1916
Query: 74 RPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGL 133
R L + + +G ++ S D K+Q + R Q
Sbjct: 1917 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1976
Query: 134 KELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEE----------QEEQMA 183
E + E EE+ +K++ + + ++ + +V+ LK +EE + +
Sbjct: 1977 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2036
Query: 184 EFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSH 243
+ +E +K + E + H +V Q K +EL++ L+Q ++++ + +
Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAV-QQKEQELQQTLQQEQSVLDQ-----LRGEAEAARRAA 2090
Query: 244 EPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKL--KLQLEEERQKC 301
E A +EAAQ E RL++ A E+ + +Q + KL+ E E++
Sbjct: 2091 EEAEEARVQAEREAAQSRRQVEEAE---RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2147
Query: 302 SRNDGTVGDLAGLQNGS---------DLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQ 352
R L Q Q + + ++++ + +L + + L++
Sbjct: 2148 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2207
Query: 353 SISRLEGQVLRYKTAAENAEKVEDEL--------KAEKRKLQRELRTALDKIEEMEMTNS 404
+ RL+ + AA +VE+EL + K K + E + + + T
Sbjct: 2208 ELQRLKAEATE---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 405 HLAKRLEKMK-----ANRTALLAQQ 424
L + EKMK A R ++ AQ+
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQE 2289
Score = 55.8 bits (133), Expect = 7e-08
Identities = 97/458 (21%), Positives = 187/458 (40%), Gaps = 79/458 (17%)
Query: 13 VKDRFSAEDEALSNIAREAE-ARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAEN 71
V D+ E EA A EAE AR+ A+R A R + E ER ++ +E++ +
Sbjct: 2075 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARAQAQ 2132
Query: 72 YTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQ 131
R A ++RR + ++L + +E+ +Q + + Q
Sbjct: 2133 AAAEKLRKEAEQ------EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2186
Query: 132 GLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEE 191
L L+ L E D++KN L ++ LK E Q ++ EE
Sbjct: 2187 ELTTLRLQLEET--------------DHQKNLLDEELQRLKAEATEAARQRSQV----EE 2228
Query: 192 KSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAIT 251
+ + Q S L+ ++E L RD+ + + + V+ E A ++
Sbjct: 2229 ELFSVRVQMEELSKLKARIEAENRALILRDK--DNTQRFLQEEAEKMKQVAEE--AARLS 2284
Query: 252 VVSQEAAQVLESAGEGPLDVRL--RKLAGEKEELLSQIRKLKLQ---------------- 293
V +QEAA++ + A E R K+ EK + + + +LK +
Sbjct: 2285 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2344
Query: 294 -LEEERQKCSRN--DGTVGDLAGLQNGSDLQFIEMQRDANR---QISEYKFKLSKAEQDI 347
L+E++++ ++ + T G L+ Q +EM +A R +++E ++AE+D
Sbjct: 2345 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKLRVAEMSRAQARAEEDA 2403
Query: 348 TTLEQSISRLEGQVLRYKTAAE------------------NAEKVED---ELKAEKRKLQ 386
+ + ++ R + A + +AE++ + EL+ EK KLQ
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2463
Query: 387 RELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 424
+E + K EEM+ + L++ +A + + L+++
Sbjct: 2464 QEAKLLQLKSEEMQTVQQE--QLLQETQALQQSFLSEK 2499
Score = 54.3 bits (129), Expect = 2e-07
Identities = 83/428 (19%), Positives = 172/428 (40%), Gaps = 43/428 (10%)
Query: 7 GRKRTPVKDRFSAEDEALSNIAR-------------EAEARLAAKRAARAEA---RDIRM 50
GR R+ +D ++++A AR EAE R+ AA EA R +
Sbjct: 1949 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008
Query: 51 RELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLS 110
E+ER + +++E ++ E + S+R A ++ + L
Sbjct: 2009 EEVERLKAKVEEA--RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2066
Query: 111 E-LRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVD 169
+ L+ + DQ++ + +E +E+ + E ++A S Q++ + +
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE---REAAQSRRQVE--------EAE 2115
Query: 170 TLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR---DELIEK 226
LK EEQ + A+ E+ KE E++ + + + LRQ+ D +EK
Sbjct: 2116 RLKQSAEEQAQARAQAQAAAEKLRKEAEQE------AARRAQAEQAALRQKQAADAEMEK 2169
Query: 227 HGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQ 286
H V E + + + + L L + A ++ ++ +
Sbjct: 2170 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2229
Query: 287 IRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQD 346
+ +++Q+EE + +R + L + +F++ + + +Q++E +LS A Q+
Sbjct: 2230 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2289
Query: 347 ITTLEQSISR--LEGQVLRYKTAAENAEKVED--ELKAEKRKLQRELRTALDKIEEMEMT 402
L Q + + L K E + V++ LKAE LQ++ A ++ ++
Sbjct: 2290 AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2349
Query: 403 NSHLAKRL 410
+A++L
Sbjct: 2350 KEQMAQQL 2357
Score = 53.5 bits (127), Expect = 4e-07
Identities = 90/445 (20%), Positives = 180/445 (40%), Gaps = 54/445 (12%)
Query: 8 RKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELE----RQQKELDEK 63
++R ++R + + AL + AEA AK A EA++++ R E R++ +D +
Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1412
Query: 64 SDKQYAENYTRPSSRNS-----ASATTPLSGNSSRRGSGDTSSLIDPDTSLSELR----- 113
K+ + + ++S A A + SR + ++ +E +
Sbjct: 1413 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1472
Query: 114 -DIYDLKDQIQDVEGRYMQGLKE---LKESLSEVEEKYKKAMV-------SNAQLDNEKN 162
++ L+ + ++ E + Q +E L+ + + ++ ++A V + A+ EK
Sbjct: 1473 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532
Query: 163 NLIYQVDTLKDVIEEQEEQM--AEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR 220
+ ++ L+ EE E ++ AE R + + Q+ + LQ K E Q
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592
Query: 221 DE-LIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGE 279
+ L E+H V + A ++ + + L +RL+
Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1652
Query: 280 KEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFK 339
+++ L+Q K + E ER+ +R G + A Q + E + + RQ++E
Sbjct: 1653 QQKSLAQAEAEKQKEEAERE--ARRRGKAEEQAVRQR----ELAEQELEKQRQLAE---- 1702
Query: 340 LSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEM 399
T +Q ++ E +++R + E E+ L+ E +LQRE A K +E+
Sbjct: 1703 --------GTAQQRLAA-EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 400 EMTNSHLAKRLEKMKANRTALLAQQ 424
E L K++A LLA +
Sbjct: 1754 E-------AELAKVRAEMEVLLASK 1771
Score = 50.8 bits (120), Expect = 2e-06
Identities = 92/442 (20%), Positives = 156/442 (35%), Gaps = 39/442 (8%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKS 64
AS ++T +R E+ RE R A ++A AR+ RELER Q + +E
Sbjct: 1583 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1642
Query: 65 D-KQYAENYTRPSSRNSASA---TTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKD 120
+ AE + S A A + RRG + ++ + + EL L +
Sbjct: 1643 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1702
Query: 121 QIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLK----DVIE 176
Q L L+ + E++ + A+L E + L+ V
Sbjct: 1703 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1762
Query: 177 EQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGT 236
E E +A R EE E+ K + EL E + L E +
Sbjct: 1763 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE--------EAK 1814
Query: 237 PNGDVSHEPVAGAITVVSQEAAQVLESAGEG-----PLDVRLRKLAGEKEELLSQIRKLK 291
++ E A + A+ L + GE ++ L++ E E L
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 292 LQLEEERQKCSRNDGTVGD-LAGLQNGSDLQF----------IEMQRDANRQISEYKFKL 340
Q ++ +++ + + LA L+ SD + + +R +I K
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1934
Query: 341 SKAEQDITTLEQSISRLEG---QVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKI- 396
KA LE + R+ LR K AE + +L AE+ + +RE + K
Sbjct: 1935 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1994
Query: 397 ---EEMEMTNSHLAKRLEKMKA 415
EE + +E++KA
Sbjct: 1995 AAEEEAARQRKAALEEVERLKA 2016
Score = 43.1 bits (100), Expect = 5e-04
Identities = 87/429 (20%), Positives = 172/429 (40%), Gaps = 51/429 (11%)
Query: 29 REAEARLAAKRAARAEARDIRMRELE---RQQKELDEKSDK--QYAENYTRPSSRNSASA 83
RE A+L + A D+R RELE RQ + E +D + ++ R R
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR---RQEQIQ 1234
Query: 84 TTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKE-------L 136
PL+ + + R L L E+ + ++ Q +Y+ +K+
Sbjct: 1235 AMPLADSQAVR-----EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1289
Query: 137 KESLSEVEEKYKKAMVSNA--QLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSK 194
K L V KK V + + E +L L + + + ++E R EE+ +
Sbjct: 1290 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349
Query: 195 ELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGD----VSHEPVAGAI 250
E+Q+ + + ++ E++ L ++ +L E H + + E V
Sbjct: 1350 LAEQQR---AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1406
Query: 251 TVVS--------QEAAQVLESAGEGPLDVRLRKL-AGEKEELL--SQIRKLKLQLEEERQ 299
V QE Q L + E + + R+ A E+ L +IR ++LQLE +
Sbjct: 1407 AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1466
Query: 300 KCSRNDGTVGDLAGLQNGSDLQFIEMQRDA---NRQISEYKFKLSKAEQDITTLEQSISR 356
+ +G + L ++ Q + Q +A RQ+ + + +AE ++ S +
Sbjct: 1467 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA----SRVK 1522
Query: 357 LEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTA-LDKIEEMEMTNSHLAKRLEKMKA 415
E + R K + A + +EL+ + + +R LR A +++ ++++ + E
Sbjct: 1523 AEAEAAREK---QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1579
Query: 416 NRTALLAQQ 424
++ A A++
Sbjct: 1580 SKRASFAEK 1588
Score = 34.7 bits (78), Expect = 0.17
Identities = 42/221 (19%), Positives = 92/221 (41%), Gaps = 28/221 (12%)
Query: 30 EAEARLAAKRAARAEARDIRMRELERQQKELDE------KSDKQYAENYTRPSSRNSASA 83
EAE + + +A AE +R+ E+ R Q +E K ++ E R
Sbjct: 2369 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2428
Query: 84 TTPLSGNSSRRGSG-DTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSE 142
T + R+ S D L + L ++ + ++ ++ MQ +++ E L +
Sbjct: 2429 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQLLQ 2486
Query: 143 VEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSK---ELERQ 199
+ +++ +S ++ I Q + + + E A+ RE +++ + E ERQ
Sbjct: 2487 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2546
Query: 200 KHMCSV----------------LQHKMEELKEGLRQRDELI 224
+ + S+ Q ++++L++ RQ++EL+
Sbjct: 2547 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2587
Score = 31.6 bits (70), Expect = 1.4
Identities = 52/273 (19%), Positives = 115/273 (42%), Gaps = 28/273 (10%)
Query: 48 IRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDT 107
++ E++RQQ + D + ++ R + A L S + L+
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL-LQLKSEEMQTVQQEQLLQETQ 2489
Query: 108 SLSELRDIYDLKDQIQDVEGRYMQGLKELKESL-----SEVEEKYKKAMVSNAQLDNEKN 162
+L + KD + E R+++ K E L ++ ++ ++ Q++ E+
Sbjct: 2490 ALQQ--SFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2546
Query: 163 NLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDE 222
L+ ++ + E EE + R +E+ ++LE+Q+ L + E + LR++ +
Sbjct: 2547 RLVASMEEARRRQHEAEEGV----RRKQEELQQLEQQRRQQEEL---LAEENQRLREQLQ 2599
Query: 223 LIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAA---QVLESAGEGPLDVRLRKLAGE 279
L+E+ + + +V+ VA T+ + A E+ E D RK++ +
Sbjct: 2600 LLEEQHRAAL---AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQ 2656
Query: 280 KEELLSQIRKLKLQLEEERQKCSRNDGTVGDLA 312
+ +++ + EE Q+ ++ TV +LA
Sbjct: 2657 R------LQEAGILSAEELQRLAQGHTTVDELA 2683
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 60.1 bits (144), Expect = 4e-09
Identities = 89/434 (20%), Positives = 180/434 (41%), Gaps = 25/434 (5%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDE-K 63
A R+ +R + + S R+AE LA++ A AEA RE +R + L+E +
Sbjct: 1455 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA----AREKQRALQALEELR 1510
Query: 64 SDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGD----TSSLIDPDTSLS-ELRDIYDL 118
+ AE R + A + R + +S + L L++ +
Sbjct: 1511 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1570
Query: 119 KDQIQDVEGRYMQGLKELKESLSEVE---EKYKKAMVSNAQLDNEKNNLIYQVDTLKDVI 175
Q+++ R Q E + + E E E+++ +L + + Q +
Sbjct: 1571 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1630
Query: 176 EEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDG 235
E+Q+E+ R + ++ RQ+ + K +L EG Q+ L + L+ +
Sbjct: 1631 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-RLAAEQELIRLRAE 1689
Query: 236 TPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQ-- 293
T G+ + + + + +EAA + E L+ L K+ E E LL+ + + +
Sbjct: 1690 TEQGEQQRQLLEEELARLQREAAAATQKRQE--LEAELAKVRAEMEVLLASKARAEEESR 1747
Query: 294 --LEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLE 351
E+ +Q+ G +LA + + L+ + + RQ++E +AE + L
Sbjct: 1748 STSEKSKQRLEAEAGRFRELA--EEAARLRALAEEAKRQRQLAEEDAARQRAEAE-RVLA 1804
Query: 352 QSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTN-SHLAKRL 410
+ ++ + G+ R KT AE A K ++ R+L + ++EE + + + +RL
Sbjct: 1805 EKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1863
Query: 411 EKMKANRTALLAQQ 424
+++ + L +Q
Sbjct: 1864 AQLRKASDSELERQ 1877
Score = 58.9 bits (141), Expect = 8e-09
Identities = 91/445 (20%), Positives = 173/445 (38%), Gaps = 64/445 (14%)
Query: 19 AEDEALSNIAREAEARLAAKRAARAEARDIRMR-----ELERQQKELDEKSDKQYAENYT 73
AEDEA E +A A+ A E R ++R ELERQ+ +++ T
Sbjct: 1838 AEDEAFQRRRLEEQA---AQHKADIEERLAQLRKASDSELERQKGLVED----------T 1884
Query: 74 RPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGL 133
R L + + +G ++ S D K+Q + R Q
Sbjct: 1885 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1944
Query: 134 KELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEE----------QEEQMA 183
E + E EE+ +K++ + + ++ + +V+ LK +EE + +
Sbjct: 1945 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2004
Query: 184 EFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSH 243
+ +E +K + E + H +V Q K +EL++ L+Q ++++ + +
Sbjct: 2005 QLAQEAAQKRLQAEEKAHAFAV-QQKEQELQQTLQQEQSVLDQ-----LRGEAEAARRAA 2058
Query: 244 EPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKL--KLQLEEERQKC 301
E A +EAAQ E RL++ A E+ + +Q + KL+ E E++
Sbjct: 2059 EEAEEARVQAEREAAQSRRQVEEAE---RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2115
Query: 302 SRNDGTVGDLAGLQNGS---------DLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQ 352
R L Q Q + + ++++ + +L + + L++
Sbjct: 2116 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2175
Query: 353 SISRLEGQVLRYKTAAENAEKVEDEL--------KAEKRKLQRELRTALDKIEEMEMTNS 404
+ RL+ + AA +VE+EL + K K + E + + + T
Sbjct: 2176 ELQRLKAEATE---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2232
Query: 405 HLAKRLEKMK-----ANRTALLAQQ 424
L + EKMK A R ++ AQ+
Sbjct: 2233 FLQEEAEKMKQVAEEAARLSVAAQE 2257
Score = 55.8 bits (133), Expect = 7e-08
Identities = 97/458 (21%), Positives = 187/458 (40%), Gaps = 79/458 (17%)
Query: 13 VKDRFSAEDEALSNIAREAE-ARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAEN 71
V D+ E EA A EAE AR+ A+R A R + E ER ++ +E++ +
Sbjct: 2043 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARAQAQ 2100
Query: 72 YTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQ 131
R A ++RR + ++L + +E+ +Q + + Q
Sbjct: 2101 AAAEKLRKEAEQ------EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2154
Query: 132 GLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEE 191
L L+ L E D++KN L ++ LK E Q ++ EE
Sbjct: 2155 ELTTLRLQLEET--------------DHQKNLLDEELQRLKAEATEAARQRSQV----EE 2196
Query: 192 KSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAIT 251
+ + Q S L+ ++E L RD+ + + + V+ E A ++
Sbjct: 2197 ELFSVRVQMEELSKLKARIEAENRALILRDK--DNTQRFLQEEAEKMKQVAEE--AARLS 2252
Query: 252 VVSQEAAQVLESAGEGPLDVRL--RKLAGEKEELLSQIRKLKLQ---------------- 293
V +QEAA++ + A E R K+ EK + + + +LK +
Sbjct: 2253 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2312
Query: 294 -LEEERQKCSRN--DGTVGDLAGLQNGSDLQFIEMQRDANR---QISEYKFKLSKAEQDI 347
L+E++++ ++ + T G L+ Q +EM +A R +++E ++AE+D
Sbjct: 2313 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKLRVAEMSRAQARAEEDA 2371
Query: 348 TTLEQSISRLEGQVLRYKTAAE------------------NAEKVED---ELKAEKRKLQ 386
+ + ++ R + A + +AE++ + EL+ EK KLQ
Sbjct: 2372 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2431
Query: 387 RELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 424
+E + K EEM+ + L++ +A + + L+++
Sbjct: 2432 QEAKLLQLKSEEMQTVQQE--QLLQETQALQQSFLSEK 2467
Score = 54.3 bits (129), Expect = 2e-07
Identities = 83/428 (19%), Positives = 172/428 (40%), Gaps = 43/428 (10%)
Query: 7 GRKRTPVKDRFSAEDEALSNIAR-------------EAEARLAAKRAARAEA---RDIRM 50
GR R+ +D ++++A AR EAE R+ AA EA R +
Sbjct: 1917 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1976
Query: 51 RELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLS 110
E+ER + +++E ++ E + S+R A ++ + L
Sbjct: 1977 EEVERLKAKVEEA--RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2034
Query: 111 E-LRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVD 169
+ L+ + DQ++ + +E +E+ + E ++A S Q++ + +
Sbjct: 2035 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE---REAAQSRRQVE--------EAE 2083
Query: 170 TLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR---DELIEK 226
LK EEQ + A+ E+ KE E++ + + + LRQ+ D +EK
Sbjct: 2084 RLKQSAEEQAQARAQAQAAAEKLRKEAEQE------AARRAQAEQAALRQKQAADAEMEK 2137
Query: 227 HGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQ 286
H V E + + + + L L + A ++ ++ +
Sbjct: 2138 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2197
Query: 287 IRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQD 346
+ +++Q+EE + +R + L + +F++ + + +Q++E +LS A Q+
Sbjct: 2198 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2257
Query: 347 ITTLEQSISR--LEGQVLRYKTAAENAEKVED--ELKAEKRKLQRELRTALDKIEEMEMT 402
L Q + + L K E + V++ LKAE LQ++ A ++ ++
Sbjct: 2258 AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2317
Query: 403 NSHLAKRL 410
+A++L
Sbjct: 2318 KEQMAQQL 2325
Score = 53.5 bits (127), Expect = 4e-07
Identities = 90/445 (20%), Positives = 180/445 (40%), Gaps = 54/445 (12%)
Query: 8 RKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELE----RQQKELDEK 63
++R ++R + + AL + AEA AK A EA++++ R E R++ +D +
Sbjct: 1321 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1380
Query: 64 SDKQYAENYTRPSSRNS-----ASATTPLSGNSSRRGSGDTSSLIDPDTSLSELR----- 113
K+ + + ++S A A + SR + ++ +E +
Sbjct: 1381 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1440
Query: 114 -DIYDLKDQIQDVEGRYMQGLKE---LKESLSEVEEKYKKAMV-------SNAQLDNEKN 162
++ L+ + ++ E + Q +E L+ + + ++ ++A V + A+ EK
Sbjct: 1441 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1500
Query: 163 NLIYQVDTLKDVIEEQEEQM--AEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR 220
+ ++ L+ EE E ++ AE R + + Q+ + LQ K E Q
Sbjct: 1501 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1560
Query: 221 DE-LIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGE 279
+ L E+H V + A ++ + + L +RL+
Sbjct: 1561 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1620
Query: 280 KEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFK 339
+++ L+Q K + E ER+ +R G + A Q + E + + RQ++E
Sbjct: 1621 QQKSLAQAEAEKQKEEAERE--ARRRGKAEEQAVRQR----ELAEQELEKQRQLAE---- 1670
Query: 340 LSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEM 399
T +Q ++ E +++R + E E+ L+ E +LQRE A K +E+
Sbjct: 1671 --------GTAQQRLAA-EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1721
Query: 400 EMTNSHLAKRLEKMKANRTALLAQQ 424
E L K++A LLA +
Sbjct: 1722 E-------AELAKVRAEMEVLLASK 1739
Score = 50.8 bits (120), Expect = 2e-06
Identities = 92/442 (20%), Positives = 156/442 (35%), Gaps = 39/442 (8%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKS 64
AS ++T +R E+ RE R A ++A AR+ RELER Q + +E
Sbjct: 1551 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1610
Query: 65 D-KQYAENYTRPSSRNSASA---TTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKD 120
+ AE + S A A + RRG + ++ + + EL L +
Sbjct: 1611 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1670
Query: 121 QIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLK----DVIE 176
Q L L+ + E++ + A+L E + L+ V
Sbjct: 1671 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1730
Query: 177 EQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGT 236
E E +A R EE E+ K + EL E + L E +
Sbjct: 1731 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE--------EAK 1782
Query: 237 PNGDVSHEPVAGAITVVSQEAAQVLESAGEG-----PLDVRLRKLAGEKEELLSQIRKLK 291
++ E A + A+ L + GE ++ L++ E E L
Sbjct: 1783 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1842
Query: 292 LQLEEERQKCSRNDGTVGD-LAGLQNGSDLQF----------IEMQRDANRQISEYKFKL 340
Q ++ +++ + + LA L+ SD + + +R +I K
Sbjct: 1843 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1902
Query: 341 SKAEQDITTLEQSISRLEG---QVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKI- 396
KA LE + R+ LR K AE + +L AE+ + +RE + K
Sbjct: 1903 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1962
Query: 397 ---EEMEMTNSHLAKRLEKMKA 415
EE + +E++KA
Sbjct: 1963 AAEEEAARQRKAALEEVERLKA 1984
Score = 43.1 bits (100), Expect = 5e-04
Identities = 87/429 (20%), Positives = 172/429 (40%), Gaps = 51/429 (11%)
Query: 29 REAEARLAAKRAARAEARDIRMRELE---RQQKELDEKSDK--QYAENYTRPSSRNSASA 83
RE A+L + A D+R RELE RQ + E +D + ++ R R
Sbjct: 1146 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR---RQEQIQ 1202
Query: 84 TTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKE-------L 136
PL+ + + R L L E+ + ++ Q +Y+ +K+
Sbjct: 1203 AMPLADSQAVR-----EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1257
Query: 137 KESLSEVEEKYKKAMVSNA--QLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSK 194
K L V KK V + + E +L L + + + ++E R EE+ +
Sbjct: 1258 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1317
Query: 195 ELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGD----VSHEPVAGAI 250
E+Q+ + + ++ E++ L ++ +L E H + + E V
Sbjct: 1318 LAEQQR---AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1374
Query: 251 TVVS--------QEAAQVLESAGEGPLDVRLRKL-AGEKEELL--SQIRKLKLQLEEERQ 299
V QE Q L + E + + R+ A E+ L +IR ++LQLE +
Sbjct: 1375 AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1434
Query: 300 KCSRNDGTVGDLAGLQNGSDLQFIEMQRDA---NRQISEYKFKLSKAEQDITTLEQSISR 356
+ +G + L ++ Q + Q +A RQ+ + + +AE ++ S +
Sbjct: 1435 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA----SRVK 1490
Query: 357 LEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTA-LDKIEEMEMTNSHLAKRLEKMKA 415
E + R K + A + +EL+ + + +R LR A +++ ++++ + E
Sbjct: 1491 AEAEAAREK---QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1547
Query: 416 NRTALLAQQ 424
++ A A++
Sbjct: 1548 SKRASFAEK 1556
Score = 34.7 bits (78), Expect = 0.17
Identities = 42/221 (19%), Positives = 92/221 (41%), Gaps = 28/221 (12%)
Query: 30 EAEARLAAKRAARAEARDIRMRELERQQKELDE------KSDKQYAENYTRPSSRNSASA 83
EAE + + +A AE +R+ E+ R Q +E K ++ E R
Sbjct: 2337 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2396
Query: 84 TTPLSGNSSRRGSG-DTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSE 142
T + R+ S D L + L ++ + ++ ++ MQ +++ E L +
Sbjct: 2397 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQLLQ 2454
Query: 143 VEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSK---ELERQ 199
+ +++ +S ++ I Q + + + E A+ RE +++ + E ERQ
Sbjct: 2455 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2514
Query: 200 KHMCSV----------------LQHKMEELKEGLRQRDELI 224
+ + S+ Q ++++L++ RQ++EL+
Sbjct: 2515 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2555
Score = 31.6 bits (70), Expect = 1.4
Identities = 52/273 (19%), Positives = 115/273 (42%), Gaps = 28/273 (10%)
Query: 48 IRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDT 107
++ E++RQQ + D + ++ R + A L S + L+
Sbjct: 2399 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL-LQLKSEEMQTVQQEQLLQETQ 2457
Query: 108 SLSELRDIYDLKDQIQDVEGRYMQGLKELKESL-----SEVEEKYKKAMVSNAQLDNEKN 162
+L + KD + E R+++ K E L ++ ++ ++ Q++ E+
Sbjct: 2458 ALQQ--SFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2514
Query: 163 NLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDE 222
L+ ++ + E EE + R +E+ ++LE+Q+ L + E + LR++ +
Sbjct: 2515 RLVASMEEARRRQHEAEEGV----RRKQEELQQLEQQRRQQEEL---LAEENQRLREQLQ 2567
Query: 223 LIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAA---QVLESAGEGPLDVRLRKLAGE 279
L+E+ + + +V+ VA T+ + A E+ E D RK++ +
Sbjct: 2568 LLEEQHRAAL---AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQ 2624
Query: 280 KEELLSQIRKLKLQLEEERQKCSRNDGTVGDLA 312
+ +++ + EE Q+ ++ TV +LA
Sbjct: 2625 R------LQEAGILSAEELQRLAQGHTTVDELA 2651
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 60.1 bits (144), Expect = 4e-09
Identities = 89/434 (20%), Positives = 180/434 (41%), Gaps = 25/434 (5%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDE-K 63
A R+ +R + + S R+AE LA++ A AEA RE +R + L+E +
Sbjct: 1624 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA----AREKQRALQALEELR 1679
Query: 64 SDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGD----TSSLIDPDTSLS-ELRDIYDL 118
+ AE R + A + R + +S + L L++ +
Sbjct: 1680 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1739
Query: 119 KDQIQDVEGRYMQGLKELKESLSEVE---EKYKKAMVSNAQLDNEKNNLIYQVDTLKDVI 175
Q+++ R Q E + + E E E+++ +L + + Q +
Sbjct: 1740 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1799
Query: 176 EEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDG 235
E+Q+E+ R + ++ RQ+ + K +L EG Q+ L + L+ +
Sbjct: 1800 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-RLAAEQELIRLRAE 1858
Query: 236 TPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQ-- 293
T G+ + + + + +EAA + E L+ L K+ E E LL+ + + +
Sbjct: 1859 TEQGEQQRQLLEEELARLQREAAAATQKRQE--LEAELAKVRAEMEVLLASKARAEEESR 1916
Query: 294 --LEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLE 351
E+ +Q+ G +LA + + L+ + + RQ++E +AE + L
Sbjct: 1917 STSEKSKQRLEAEAGRFRELA--EEAARLRALAEEAKRQRQLAEEDAARQRAEAE-RVLA 1973
Query: 352 QSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTN-SHLAKRL 410
+ ++ + G+ R KT AE A K ++ R+L + ++EE + + + +RL
Sbjct: 1974 EKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 2032
Query: 411 EKMKANRTALLAQQ 424
+++ + L +Q
Sbjct: 2033 AQLRKASDSELERQ 2046
Score = 58.9 bits (141), Expect = 8e-09
Identities = 91/445 (20%), Positives = 173/445 (38%), Gaps = 64/445 (14%)
Query: 19 AEDEALSNIAREAEARLAAKRAARAEARDIRMR-----ELERQQKELDEKSDKQYAENYT 73
AEDEA E +A A+ A E R ++R ELERQ+ +++ T
Sbjct: 2007 AEDEAFQRRRLEEQA---AQHKADIEERLAQLRKASDSELERQKGLVED----------T 2053
Query: 74 RPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGL 133
R L + + +G ++ S D K+Q + R Q
Sbjct: 2054 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 2113
Query: 134 KELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEE----------QEEQMA 183
E + E EE+ +K++ + + ++ + +V+ LK +EE + +
Sbjct: 2114 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2173
Query: 184 EFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSH 243
+ +E +K + E + H +V Q K +EL++ L+Q ++++ + +
Sbjct: 2174 QLAQEAAQKRLQAEEKAHAFAV-QQKEQELQQTLQQEQSVLDQ-----LRGEAEAARRAA 2227
Query: 244 EPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKL--KLQLEEERQKC 301
E A +EAAQ E RL++ A E+ + +Q + KL+ E E++
Sbjct: 2228 EEAEEARVQAEREAAQSRRQVEEAE---RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2284
Query: 302 SRNDGTVGDLAGLQNGS---------DLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQ 352
R L Q Q + + ++++ + +L + + L++
Sbjct: 2285 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2344
Query: 353 SISRLEGQVLRYKTAAENAEKVEDEL--------KAEKRKLQRELRTALDKIEEMEMTNS 404
+ RL+ + AA +VE+EL + K K + E + + + T
Sbjct: 2345 ELQRLKAEATE---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401
Query: 405 HLAKRLEKMK-----ANRTALLAQQ 424
L + EKMK A R ++ AQ+
Sbjct: 2402 FLQEEAEKMKQVAEEAARLSVAAQE 2426
Score = 55.8 bits (133), Expect = 7e-08
Identities = 97/458 (21%), Positives = 187/458 (40%), Gaps = 79/458 (17%)
Query: 13 VKDRFSAEDEALSNIAREAE-ARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAEN 71
V D+ E EA A EAE AR+ A+R A R + E ER ++ +E++ +
Sbjct: 2212 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARAQAQ 2269
Query: 72 YTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQ 131
R A ++RR + ++L + +E+ +Q + + Q
Sbjct: 2270 AAAEKLRKEAEQ------EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2323
Query: 132 GLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEE 191
L L+ L E D++KN L ++ LK E Q ++ EE
Sbjct: 2324 ELTTLRLQLEET--------------DHQKNLLDEELQRLKAEATEAARQRSQV----EE 2365
Query: 192 KSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAIT 251
+ + Q S L+ ++E L RD+ + + + V+ E A ++
Sbjct: 2366 ELFSVRVQMEELSKLKARIEAENRALILRDK--DNTQRFLQEEAEKMKQVAEE--AARLS 2421
Query: 252 VVSQEAAQVLESAGEGPLDVRL--RKLAGEKEELLSQIRKLKLQ---------------- 293
V +QEAA++ + A E R K+ EK + + + +LK +
Sbjct: 2422 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2481
Query: 294 -LEEERQKCSRN--DGTVGDLAGLQNGSDLQFIEMQRDANR---QISEYKFKLSKAEQDI 347
L+E++++ ++ + T G L+ Q +EM +A R +++E ++AE+D
Sbjct: 2482 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKLRVAEMSRAQARAEEDA 2540
Query: 348 TTLEQSISRLEGQVLRYKTAAE------------------NAEKVED---ELKAEKRKLQ 386
+ + ++ R + A + +AE++ + EL+ EK KLQ
Sbjct: 2541 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2600
Query: 387 RELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 424
+E + K EEM+ + L++ +A + + L+++
Sbjct: 2601 QEAKLLQLKSEEMQTVQQE--QLLQETQALQQSFLSEK 2636
Score = 54.3 bits (129), Expect = 2e-07
Identities = 83/428 (19%), Positives = 172/428 (40%), Gaps = 43/428 (10%)
Query: 7 GRKRTPVKDRFSAEDEALSNIAR-------------EAEARLAAKRAARAEA---RDIRM 50
GR R+ +D ++++A AR EAE R+ AA EA R +
Sbjct: 2086 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2145
Query: 51 RELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLS 110
E+ER + +++E ++ E + S+R A ++ + L
Sbjct: 2146 EEVERLKAKVEEA--RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2203
Query: 111 E-LRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVD 169
+ L+ + DQ++ + +E +E+ + E ++A S Q++ + +
Sbjct: 2204 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE---REAAQSRRQVE--------EAE 2252
Query: 170 TLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR---DELIEK 226
LK EEQ + A+ E+ KE E++ + + + LRQ+ D +EK
Sbjct: 2253 RLKQSAEEQAQARAQAQAAAEKLRKEAEQE------AARRAQAEQAALRQKQAADAEMEK 2306
Query: 227 HGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQ 286
H V E + + + + L L + A ++ ++ +
Sbjct: 2307 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2366
Query: 287 IRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQD 346
+ +++Q+EE + +R + L + +F++ + + +Q++E +LS A Q+
Sbjct: 2367 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2426
Query: 347 ITTLEQSISR--LEGQVLRYKTAAENAEKVED--ELKAEKRKLQRELRTALDKIEEMEMT 402
L Q + + L K E + V++ LKAE LQ++ A ++ ++
Sbjct: 2427 AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2486
Query: 403 NSHLAKRL 410
+A++L
Sbjct: 2487 KEQMAQQL 2494
Score = 53.5 bits (127), Expect = 4e-07
Identities = 90/445 (20%), Positives = 180/445 (40%), Gaps = 54/445 (12%)
Query: 8 RKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELE----RQQKELDEK 63
++R ++R + + AL + AEA AK A EA++++ R E R++ +D +
Sbjct: 1490 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1549
Query: 64 SDKQYAENYTRPSSRNS-----ASATTPLSGNSSRRGSGDTSSLIDPDTSLSELR----- 113
K+ + + ++S A A + SR + ++ +E +
Sbjct: 1550 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1609
Query: 114 -DIYDLKDQIQDVEGRYMQGLKE---LKESLSEVEEKYKKAMV-------SNAQLDNEKN 162
++ L+ + ++ E + Q +E L+ + + ++ ++A V + A+ EK
Sbjct: 1610 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1669
Query: 163 NLIYQVDTLKDVIEEQEEQM--AEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR 220
+ ++ L+ EE E ++ AE R + + Q+ + LQ K E Q
Sbjct: 1670 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1729
Query: 221 DE-LIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGE 279
+ L E+H V + A ++ + + L +RL+
Sbjct: 1730 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1789
Query: 280 KEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFK 339
+++ L+Q K + E ER+ +R G + A Q + E + + RQ++E
Sbjct: 1790 QQKSLAQAEAEKQKEEAERE--ARRRGKAEEQAVRQR----ELAEQELEKQRQLAE---- 1839
Query: 340 LSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEM 399
T +Q ++ E +++R + E E+ L+ E +LQRE A K +E+
Sbjct: 1840 --------GTAQQRLAA-EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1890
Query: 400 EMTNSHLAKRLEKMKANRTALLAQQ 424
E L K++A LLA +
Sbjct: 1891 E-------AELAKVRAEMEVLLASK 1908
Score = 50.8 bits (120), Expect = 2e-06
Identities = 92/442 (20%), Positives = 156/442 (35%), Gaps = 39/442 (8%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKS 64
AS ++T +R E+ RE R A ++A AR+ RELER Q + +E
Sbjct: 1720 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1779
Query: 65 D-KQYAENYTRPSSRNSASA---TTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKD 120
+ AE + S A A + RRG + ++ + + EL L +
Sbjct: 1780 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1839
Query: 121 QIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLK----DVIE 176
Q L L+ + E++ + A+L E + L+ V
Sbjct: 1840 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1899
Query: 177 EQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGT 236
E E +A R EE E+ K + EL E + L E +
Sbjct: 1900 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE--------EAK 1951
Query: 237 PNGDVSHEPVAGAITVVSQEAAQVLESAGEG-----PLDVRLRKLAGEKEELLSQIRKLK 291
++ E A + A+ L + GE ++ L++ E E L
Sbjct: 1952 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 2011
Query: 292 LQLEEERQKCSRNDGTVGD-LAGLQNGSDLQF----------IEMQRDANRQISEYKFKL 340
Q ++ +++ + + LA L+ SD + + +R +I K
Sbjct: 2012 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 2071
Query: 341 SKAEQDITTLEQSISRLEG---QVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKI- 396
KA LE + R+ LR K AE + +L AE+ + +RE + K
Sbjct: 2072 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 2131
Query: 397 ---EEMEMTNSHLAKRLEKMKA 415
EE + +E++KA
Sbjct: 2132 AAEEEAARQRKAALEEVERLKA 2153
Score = 43.1 bits (100), Expect = 5e-04
Identities = 87/429 (20%), Positives = 172/429 (40%), Gaps = 51/429 (11%)
Query: 29 REAEARLAAKRAARAEARDIRMRELE---RQQKELDEKSDK--QYAENYTRPSSRNSASA 83
RE A+L + A D+R RELE RQ + E +D + ++ R R
Sbjct: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR---RQEQIQ 1371
Query: 84 TTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKE-------L 136
PL+ + + R L L E+ + ++ Q +Y+ +K+
Sbjct: 1372 AMPLADSQAVR-----EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1426
Query: 137 KESLSEVEEKYKKAMVSNA--QLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSK 194
K L V KK V + + E +L L + + + ++E R EE+ +
Sbjct: 1427 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1486
Query: 195 ELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGD----VSHEPVAGAI 250
E+Q+ + + ++ E++ L ++ +L E H + + E V
Sbjct: 1487 LAEQQR---AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1543
Query: 251 TVVS--------QEAAQVLESAGEGPLDVRLRKL-AGEKEELL--SQIRKLKLQLEEERQ 299
V QE Q L + E + + R+ A E+ L +IR ++LQLE +
Sbjct: 1544 AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1603
Query: 300 KCSRNDGTVGDLAGLQNGSDLQFIEMQRDA---NRQISEYKFKLSKAEQDITTLEQSISR 356
+ +G + L ++ Q + Q +A RQ+ + + +AE ++ S +
Sbjct: 1604 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA----SRVK 1659
Query: 357 LEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTA-LDKIEEMEMTNSHLAKRLEKMKA 415
E + R K + A + +EL+ + + +R LR A +++ ++++ + E
Sbjct: 1660 AEAEAAREK---QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1716
Query: 416 NRTALLAQQ 424
++ A A++
Sbjct: 1717 SKRASFAEK 1725
Score = 34.7 bits (78), Expect = 0.17
Identities = 42/221 (19%), Positives = 92/221 (41%), Gaps = 28/221 (12%)
Query: 30 EAEARLAAKRAARAEARDIRMRELERQQKELDE------KSDKQYAENYTRPSSRNSASA 83
EAE + + +A AE +R+ E+ R Q +E K ++ E R
Sbjct: 2506 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2565
Query: 84 TTPLSGNSSRRGSG-DTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSE 142
T + R+ S D L + L ++ + ++ ++ MQ +++ E L +
Sbjct: 2566 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQLLQ 2623
Query: 143 VEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSK---ELERQ 199
+ +++ +S ++ I Q + + + E A+ RE +++ + E ERQ
Sbjct: 2624 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2683
Query: 200 KHMCSV----------------LQHKMEELKEGLRQRDELI 224
+ + S+ Q ++++L++ RQ++EL+
Sbjct: 2684 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2724
Score = 31.6 bits (70), Expect = 1.4
Identities = 52/273 (19%), Positives = 115/273 (42%), Gaps = 28/273 (10%)
Query: 48 IRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDT 107
++ E++RQQ + D + ++ R + A L S + L+
Sbjct: 2568 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL-LQLKSEEMQTVQQEQLLQETQ 2626
Query: 108 SLSELRDIYDLKDQIQDVEGRYMQGLKELKESL-----SEVEEKYKKAMVSNAQLDNEKN 162
+L + KD + E R+++ K E L ++ ++ ++ Q++ E+
Sbjct: 2627 ALQQ--SFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2683
Query: 163 NLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDE 222
L+ ++ + E EE + R +E+ ++LE+Q+ L + E + LR++ +
Sbjct: 2684 RLVASMEEARRRQHEAEEGV----RRKQEELQQLEQQRRQQEEL---LAEENQRLREQLQ 2736
Query: 223 LIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAA---QVLESAGEGPLDVRLRKLAGE 279
L+E+ + + +V+ VA T+ + A E+ E D RK++ +
Sbjct: 2737 LLEEQHRAAL---AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQ 2793
Query: 280 KEELLSQIRKLKLQLEEERQKCSRNDGTVGDLA 312
+ +++ + EE Q+ ++ TV +LA
Sbjct: 2794 R------LQEAGILSAEELQRLAQGHTTVDELA 2820
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 60.1 bits (144), Expect = 4e-09
Identities = 89/434 (20%), Positives = 180/434 (41%), Gaps = 25/434 (5%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDE-K 63
A R+ +R + + S R+AE LA++ A AEA RE +R + L+E +
Sbjct: 1465 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA----AREKQRALQALEELR 1520
Query: 64 SDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGD----TSSLIDPDTSLS-ELRDIYDL 118
+ AE R + A + R + +S + L L++ +
Sbjct: 1521 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1580
Query: 119 KDQIQDVEGRYMQGLKELKESLSEVE---EKYKKAMVSNAQLDNEKNNLIYQVDTLKDVI 175
Q+++ R Q E + + E E E+++ +L + + Q +
Sbjct: 1581 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1640
Query: 176 EEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDG 235
E+Q+E+ R + ++ RQ+ + K +L EG Q+ L + L+ +
Sbjct: 1641 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-RLAAEQELIRLRAE 1699
Query: 236 TPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQ-- 293
T G+ + + + + +EAA + E L+ L K+ E E LL+ + + +
Sbjct: 1700 TEQGEQQRQLLEEELARLQREAAAATQKRQE--LEAELAKVRAEMEVLLASKARAEEESR 1757
Query: 294 --LEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLE 351
E+ +Q+ G +LA + + L+ + + RQ++E +AE + L
Sbjct: 1758 STSEKSKQRLEAEAGRFRELA--EEAARLRALAEEAKRQRQLAEEDAARQRAEAE-RVLA 1814
Query: 352 QSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTN-SHLAKRL 410
+ ++ + G+ R KT AE A K ++ R+L + ++EE + + + +RL
Sbjct: 1815 EKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1873
Query: 411 EKMKANRTALLAQQ 424
+++ + L +Q
Sbjct: 1874 AQLRKASDSELERQ 1887
Score = 58.9 bits (141), Expect = 8e-09
Identities = 91/445 (20%), Positives = 173/445 (38%), Gaps = 64/445 (14%)
Query: 19 AEDEALSNIAREAEARLAAKRAARAEARDIRMR-----ELERQQKELDEKSDKQYAENYT 73
AEDEA E +A A+ A E R ++R ELERQ+ +++ T
Sbjct: 1848 AEDEAFQRRRLEEQA---AQHKADIEERLAQLRKASDSELERQKGLVED----------T 1894
Query: 74 RPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGL 133
R L + + +G ++ S D K+Q + R Q
Sbjct: 1895 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1954
Query: 134 KELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEE----------QEEQMA 183
E + E EE+ +K++ + + ++ + +V+ LK +EE + +
Sbjct: 1955 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2014
Query: 184 EFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSH 243
+ +E +K + E + H +V Q K +EL++ L+Q ++++ + +
Sbjct: 2015 QLAQEAAQKRLQAEEKAHAFAV-QQKEQELQQTLQQEQSVLDQ-----LRGEAEAARRAA 2068
Query: 244 EPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKL--KLQLEEERQKC 301
E A +EAAQ E RL++ A E+ + +Q + KL+ E E++
Sbjct: 2069 EEAEEARVQAEREAAQSRRQVEEAE---RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2125
Query: 302 SRNDGTVGDLAGLQNGS---------DLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQ 352
R L Q Q + + ++++ + +L + + L++
Sbjct: 2126 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2185
Query: 353 SISRLEGQVLRYKTAAENAEKVEDEL--------KAEKRKLQRELRTALDKIEEMEMTNS 404
+ RL+ + AA +VE+EL + K K + E + + + T
Sbjct: 2186 ELQRLKAEATE---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242
Query: 405 HLAKRLEKMK-----ANRTALLAQQ 424
L + EKMK A R ++ AQ+
Sbjct: 2243 FLQEEAEKMKQVAEEAARLSVAAQE 2267
Score = 55.8 bits (133), Expect = 7e-08
Identities = 97/458 (21%), Positives = 187/458 (40%), Gaps = 79/458 (17%)
Query: 13 VKDRFSAEDEALSNIAREAE-ARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAEN 71
V D+ E EA A EAE AR+ A+R A R + E ER ++ +E++ +
Sbjct: 2053 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARAQAQ 2110
Query: 72 YTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQ 131
R A ++RR + ++L + +E+ +Q + + Q
Sbjct: 2111 AAAEKLRKEAEQ------EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2164
Query: 132 GLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEE 191
L L+ L E D++KN L ++ LK E Q ++ EE
Sbjct: 2165 ELTTLRLQLEET--------------DHQKNLLDEELQRLKAEATEAARQRSQV----EE 2206
Query: 192 KSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAIT 251
+ + Q S L+ ++E L RD+ + + + V+ E A ++
Sbjct: 2207 ELFSVRVQMEELSKLKARIEAENRALILRDK--DNTQRFLQEEAEKMKQVAEE--AARLS 2262
Query: 252 VVSQEAAQVLESAGEGPLDVRL--RKLAGEKEELLSQIRKLKLQ---------------- 293
V +QEAA++ + A E R K+ EK + + + +LK +
Sbjct: 2263 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2322
Query: 294 -LEEERQKCSRN--DGTVGDLAGLQNGSDLQFIEMQRDANR---QISEYKFKLSKAEQDI 347
L+E++++ ++ + T G L+ Q +EM +A R +++E ++AE+D
Sbjct: 2323 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKLRVAEMSRAQARAEEDA 2381
Query: 348 TTLEQSISRLEGQVLRYKTAAE------------------NAEKVED---ELKAEKRKLQ 386
+ + ++ R + A + +AE++ + EL+ EK KLQ
Sbjct: 2382 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2441
Query: 387 RELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 424
+E + K EEM+ + L++ +A + + L+++
Sbjct: 2442 QEAKLLQLKSEEMQTVQQE--QLLQETQALQQSFLSEK 2477
Score = 54.3 bits (129), Expect = 2e-07
Identities = 83/428 (19%), Positives = 172/428 (40%), Gaps = 43/428 (10%)
Query: 7 GRKRTPVKDRFSAEDEALSNIAR-------------EAEARLAAKRAARAEA---RDIRM 50
GR R+ +D ++++A AR EAE R+ AA EA R +
Sbjct: 1927 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1986
Query: 51 RELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLS 110
E+ER + +++E ++ E + S+R A ++ + L
Sbjct: 1987 EEVERLKAKVEEA--RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2044
Query: 111 E-LRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVD 169
+ L+ + DQ++ + +E +E+ + E ++A S Q++ + +
Sbjct: 2045 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE---REAAQSRRQVE--------EAE 2093
Query: 170 TLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR---DELIEK 226
LK EEQ + A+ E+ KE E++ + + + LRQ+ D +EK
Sbjct: 2094 RLKQSAEEQAQARAQAQAAAEKLRKEAEQE------AARRAQAEQAALRQKQAADAEMEK 2147
Query: 227 HGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQ 286
H V E + + + + L L + A ++ ++ +
Sbjct: 2148 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2207
Query: 287 IRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQD 346
+ +++Q+EE + +R + L + +F++ + + +Q++E +LS A Q+
Sbjct: 2208 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2267
Query: 347 ITTLEQSISR--LEGQVLRYKTAAENAEKVED--ELKAEKRKLQRELRTALDKIEEMEMT 402
L Q + + L K E + V++ LKAE LQ++ A ++ ++
Sbjct: 2268 AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2327
Query: 403 NSHLAKRL 410
+A++L
Sbjct: 2328 KEQMAQQL 2335
Score = 53.5 bits (127), Expect = 4e-07
Identities = 90/445 (20%), Positives = 180/445 (40%), Gaps = 54/445 (12%)
Query: 8 RKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELE----RQQKELDEK 63
++R ++R + + AL + AEA AK A EA++++ R E R++ +D +
Sbjct: 1331 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1390
Query: 64 SDKQYAENYTRPSSRNS-----ASATTPLSGNSSRRGSGDTSSLIDPDTSLSELR----- 113
K+ + + ++S A A + SR + ++ +E +
Sbjct: 1391 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1450
Query: 114 -DIYDLKDQIQDVEGRYMQGLKE---LKESLSEVEEKYKKAMV-------SNAQLDNEKN 162
++ L+ + ++ E + Q +E L+ + + ++ ++A V + A+ EK
Sbjct: 1451 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1510
Query: 163 NLIYQVDTLKDVIEEQEEQM--AEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR 220
+ ++ L+ EE E ++ AE R + + Q+ + LQ K E Q
Sbjct: 1511 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1570
Query: 221 DE-LIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGE 279
+ L E+H V + A ++ + + L +RL+
Sbjct: 1571 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1630
Query: 280 KEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFK 339
+++ L+Q K + E ER+ +R G + A Q + E + + RQ++E
Sbjct: 1631 QQKSLAQAEAEKQKEEAERE--ARRRGKAEEQAVRQR----ELAEQELEKQRQLAE---- 1680
Query: 340 LSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEM 399
T +Q ++ E +++R + E E+ L+ E +LQRE A K +E+
Sbjct: 1681 --------GTAQQRLAA-EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1731
Query: 400 EMTNSHLAKRLEKMKANRTALLAQQ 424
E L K++A LLA +
Sbjct: 1732 E-------AELAKVRAEMEVLLASK 1749
Score = 50.8 bits (120), Expect = 2e-06
Identities = 92/442 (20%), Positives = 156/442 (35%), Gaps = 39/442 (8%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKS 64
AS ++T +R E+ RE R A ++A AR+ RELER Q + +E
Sbjct: 1561 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1620
Query: 65 D-KQYAENYTRPSSRNSASA---TTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKD 120
+ AE + S A A + RRG + ++ + + EL L +
Sbjct: 1621 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1680
Query: 121 QIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLK----DVIE 176
Q L L+ + E++ + A+L E + L+ V
Sbjct: 1681 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1740
Query: 177 EQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGT 236
E E +A R EE E+ K + EL E + L E +
Sbjct: 1741 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE--------EAK 1792
Query: 237 PNGDVSHEPVAGAITVVSQEAAQVLESAGEG-----PLDVRLRKLAGEKEELLSQIRKLK 291
++ E A + A+ L + GE ++ L++ E E L
Sbjct: 1793 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1852
Query: 292 LQLEEERQKCSRNDGTVGD-LAGLQNGSDLQF----------IEMQRDANRQISEYKFKL 340
Q ++ +++ + + LA L+ SD + + +R +I K
Sbjct: 1853 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1912
Query: 341 SKAEQDITTLEQSISRLEG---QVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKI- 396
KA LE + R+ LR K AE + +L AE+ + +RE + K
Sbjct: 1913 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1972
Query: 397 ---EEMEMTNSHLAKRLEKMKA 415
EE + +E++KA
Sbjct: 1973 AAEEEAARQRKAALEEVERLKA 1994
Score = 43.1 bits (100), Expect = 5e-04
Identities = 87/429 (20%), Positives = 172/429 (40%), Gaps = 51/429 (11%)
Query: 29 REAEARLAAKRAARAEARDIRMRELE---RQQKELDEKSDK--QYAENYTRPSSRNSASA 83
RE A+L + A D+R RELE RQ + E +D + ++ R R
Sbjct: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR---RQEQIQ 1212
Query: 84 TTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKE-------L 136
PL+ + + R L L E+ + ++ Q +Y+ +K+
Sbjct: 1213 AMPLADSQAVR-----EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1267
Query: 137 KESLSEVEEKYKKAMVSNA--QLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSK 194
K L V KK V + + E +L L + + + ++E R EE+ +
Sbjct: 1268 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1327
Query: 195 ELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGD----VSHEPVAGAI 250
E+Q+ + + ++ E++ L ++ +L E H + + E V
Sbjct: 1328 LAEQQR---AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1384
Query: 251 TVVS--------QEAAQVLESAGEGPLDVRLRKL-AGEKEELL--SQIRKLKLQLEEERQ 299
V QE Q L + E + + R+ A E+ L +IR ++LQLE +
Sbjct: 1385 AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1444
Query: 300 KCSRNDGTVGDLAGLQNGSDLQFIEMQRDA---NRQISEYKFKLSKAEQDITTLEQSISR 356
+ +G + L ++ Q + Q +A RQ+ + + +AE ++ S +
Sbjct: 1445 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA----SRVK 1500
Query: 357 LEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTA-LDKIEEMEMTNSHLAKRLEKMKA 415
E + R K + A + +EL+ + + +R LR A +++ ++++ + E
Sbjct: 1501 AEAEAAREK---QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1557
Query: 416 NRTALLAQQ 424
++ A A++
Sbjct: 1558 SKRASFAEK 1566
Score = 34.7 bits (78), Expect = 0.17
Identities = 42/221 (19%), Positives = 92/221 (41%), Gaps = 28/221 (12%)
Query: 30 EAEARLAAKRAARAEARDIRMRELERQQKELDE------KSDKQYAENYTRPSSRNSASA 83
EAE + + +A AE +R+ E+ R Q +E K ++ E R
Sbjct: 2347 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2406
Query: 84 TTPLSGNSSRRGSG-DTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSE 142
T + R+ S D L + L ++ + ++ ++ MQ +++ E L +
Sbjct: 2407 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQLLQ 2464
Query: 143 VEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSK---ELERQ 199
+ +++ +S ++ I Q + + + E A+ RE +++ + E ERQ
Sbjct: 2465 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2524
Query: 200 KHMCSV----------------LQHKMEELKEGLRQRDELI 224
+ + S+ Q ++++L++ RQ++EL+
Sbjct: 2525 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2565
Score = 31.6 bits (70), Expect = 1.4
Identities = 52/273 (19%), Positives = 115/273 (42%), Gaps = 28/273 (10%)
Query: 48 IRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDT 107
++ E++RQQ + D + ++ R + A L S + L+
Sbjct: 2409 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL-LQLKSEEMQTVQQEQLLQETQ 2467
Query: 108 SLSELRDIYDLKDQIQDVEGRYMQGLKELKESL-----SEVEEKYKKAMVSNAQLDNEKN 162
+L + KD + E R+++ K E L ++ ++ ++ Q++ E+
Sbjct: 2468 ALQQ--SFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2524
Query: 163 NLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDE 222
L+ ++ + E EE + R +E+ ++LE+Q+ L + E + LR++ +
Sbjct: 2525 RLVASMEEARRRQHEAEEGV----RRKQEELQQLEQQRRQQEEL---LAEENQRLREQLQ 2577
Query: 223 LIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAA---QVLESAGEGPLDVRLRKLAGE 279
L+E+ + + +V+ VA T+ + A E+ E D RK++ +
Sbjct: 2578 LLEEQHRAAL---AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQ 2634
Query: 280 KEELLSQIRKLKLQLEEERQKCSRNDGTVGDLA 312
+ +++ + EE Q+ ++ TV +LA
Sbjct: 2635 R------LQEAGILSAEELQRLAQGHTTVDELA 2661
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 60.1 bits (144), Expect = 4e-09
Identities = 89/434 (20%), Positives = 180/434 (41%), Gaps = 25/434 (5%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDE-K 63
A R+ +R + + S R+AE LA++ A AEA RE +R + L+E +
Sbjct: 1473 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA----AREKQRALQALEELR 1528
Query: 64 SDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGD----TSSLIDPDTSLS-ELRDIYDL 118
+ AE R + A + R + +S + L L++ +
Sbjct: 1529 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1588
Query: 119 KDQIQDVEGRYMQGLKELKESLSEVE---EKYKKAMVSNAQLDNEKNNLIYQVDTLKDVI 175
Q+++ R Q E + + E E E+++ +L + + Q +
Sbjct: 1589 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1648
Query: 176 EEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDG 235
E+Q+E+ R + ++ RQ+ + K +L EG Q+ L + L+ +
Sbjct: 1649 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-RLAAEQELIRLRAE 1707
Query: 236 TPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQ-- 293
T G+ + + + + +EAA + E L+ L K+ E E LL+ + + +
Sbjct: 1708 TEQGEQQRQLLEEELARLQREAAAATQKRQE--LEAELAKVRAEMEVLLASKARAEEESR 1765
Query: 294 --LEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLE 351
E+ +Q+ G +LA + + L+ + + RQ++E +AE + L
Sbjct: 1766 STSEKSKQRLEAEAGRFRELA--EEAARLRALAEEAKRQRQLAEEDAARQRAEAE-RVLA 1822
Query: 352 QSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTN-SHLAKRL 410
+ ++ + G+ R KT AE A K ++ R+L + ++EE + + + +RL
Sbjct: 1823 EKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1881
Query: 411 EKMKANRTALLAQQ 424
+++ + L +Q
Sbjct: 1882 AQLRKASDSELERQ 1895
Score = 58.9 bits (141), Expect = 8e-09
Identities = 91/445 (20%), Positives = 173/445 (38%), Gaps = 64/445 (14%)
Query: 19 AEDEALSNIAREAEARLAAKRAARAEARDIRMR-----ELERQQKELDEKSDKQYAENYT 73
AEDEA E +A A+ A E R ++R ELERQ+ +++ T
Sbjct: 1856 AEDEAFQRRRLEEQA---AQHKADIEERLAQLRKASDSELERQKGLVED----------T 1902
Query: 74 RPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGL 133
R L + + +G ++ S D K+Q + R Q
Sbjct: 1903 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1962
Query: 134 KELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEE----------QEEQMA 183
E + E EE+ +K++ + + ++ + +V+ LK +EE + +
Sbjct: 1963 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2022
Query: 184 EFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSH 243
+ +E +K + E + H +V Q K +EL++ L+Q ++++ + +
Sbjct: 2023 QLAQEAAQKRLQAEEKAHAFAV-QQKEQELQQTLQQEQSVLDQ-----LRGEAEAARRAA 2076
Query: 244 EPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKL--KLQLEEERQKC 301
E A +EAAQ E RL++ A E+ + +Q + KL+ E E++
Sbjct: 2077 EEAEEARVQAEREAAQSRRQVEEAE---RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2133
Query: 302 SRNDGTVGDLAGLQNGS---------DLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQ 352
R L Q Q + + ++++ + +L + + L++
Sbjct: 2134 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2193
Query: 353 SISRLEGQVLRYKTAAENAEKVEDEL--------KAEKRKLQRELRTALDKIEEMEMTNS 404
+ RL+ + AA +VE+EL + K K + E + + + T
Sbjct: 2194 ELQRLKAEATE---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2250
Query: 405 HLAKRLEKMK-----ANRTALLAQQ 424
L + EKMK A R ++ AQ+
Sbjct: 2251 FLQEEAEKMKQVAEEAARLSVAAQE 2275
Score = 55.8 bits (133), Expect = 7e-08
Identities = 97/458 (21%), Positives = 187/458 (40%), Gaps = 79/458 (17%)
Query: 13 VKDRFSAEDEALSNIAREAE-ARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAEN 71
V D+ E EA A EAE AR+ A+R A R + E ER ++ +E++ +
Sbjct: 2061 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARAQAQ 2118
Query: 72 YTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQ 131
R A ++RR + ++L + +E+ +Q + + Q
Sbjct: 2119 AAAEKLRKEAEQ------EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2172
Query: 132 GLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEE 191
L L+ L E D++KN L ++ LK E Q ++ EE
Sbjct: 2173 ELTTLRLQLEET--------------DHQKNLLDEELQRLKAEATEAARQRSQV----EE 2214
Query: 192 KSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAIT 251
+ + Q S L+ ++E L RD+ + + + V+ E A ++
Sbjct: 2215 ELFSVRVQMEELSKLKARIEAENRALILRDK--DNTQRFLQEEAEKMKQVAEE--AARLS 2270
Query: 252 VVSQEAAQVLESAGEGPLDVRL--RKLAGEKEELLSQIRKLKLQ---------------- 293
V +QEAA++ + A E R K+ EK + + + +LK +
Sbjct: 2271 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2330
Query: 294 -LEEERQKCSRN--DGTVGDLAGLQNGSDLQFIEMQRDANR---QISEYKFKLSKAEQDI 347
L+E++++ ++ + T G L+ Q +EM +A R +++E ++AE+D
Sbjct: 2331 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKLRVAEMSRAQARAEEDA 2389
Query: 348 TTLEQSISRLEGQVLRYKTAAE------------------NAEKVED---ELKAEKRKLQ 386
+ + ++ R + A + +AE++ + EL+ EK KLQ
Sbjct: 2390 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2449
Query: 387 RELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 424
+E + K EEM+ + L++ +A + + L+++
Sbjct: 2450 QEAKLLQLKSEEMQTVQQE--QLLQETQALQQSFLSEK 2485
Score = 54.3 bits (129), Expect = 2e-07
Identities = 83/428 (19%), Positives = 172/428 (40%), Gaps = 43/428 (10%)
Query: 7 GRKRTPVKDRFSAEDEALSNIAR-------------EAEARLAAKRAARAEA---RDIRM 50
GR R+ +D ++++A AR EAE R+ AA EA R +
Sbjct: 1935 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1994
Query: 51 RELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLS 110
E+ER + +++E ++ E + S+R A ++ + L
Sbjct: 1995 EEVERLKAKVEEA--RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2052
Query: 111 E-LRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVD 169
+ L+ + DQ++ + +E +E+ + E ++A S Q++ + +
Sbjct: 2053 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE---REAAQSRRQVE--------EAE 2101
Query: 170 TLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR---DELIEK 226
LK EEQ + A+ E+ KE E++ + + + LRQ+ D +EK
Sbjct: 2102 RLKQSAEEQAQARAQAQAAAEKLRKEAEQE------AARRAQAEQAALRQKQAADAEMEK 2155
Query: 227 HGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQ 286
H V E + + + + L L + A ++ ++ +
Sbjct: 2156 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2215
Query: 287 IRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQD 346
+ +++Q+EE + +R + L + +F++ + + +Q++E +LS A Q+
Sbjct: 2216 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2275
Query: 347 ITTLEQSISR--LEGQVLRYKTAAENAEKVED--ELKAEKRKLQRELRTALDKIEEMEMT 402
L Q + + L K E + V++ LKAE LQ++ A ++ ++
Sbjct: 2276 AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2335
Query: 403 NSHLAKRL 410
+A++L
Sbjct: 2336 KEQMAQQL 2343
Score = 53.5 bits (127), Expect = 4e-07
Identities = 90/445 (20%), Positives = 180/445 (40%), Gaps = 54/445 (12%)
Query: 8 RKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELE----RQQKELDEK 63
++R ++R + + AL + AEA AK A EA++++ R E R++ +D +
Sbjct: 1339 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1398
Query: 64 SDKQYAENYTRPSSRNS-----ASATTPLSGNSSRRGSGDTSSLIDPDTSLSELR----- 113
K+ + + ++S A A + SR + ++ +E +
Sbjct: 1399 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1458
Query: 114 -DIYDLKDQIQDVEGRYMQGLKE---LKESLSEVEEKYKKAMV-------SNAQLDNEKN 162
++ L+ + ++ E + Q +E L+ + + ++ ++A V + A+ EK
Sbjct: 1459 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1518
Query: 163 NLIYQVDTLKDVIEEQEEQM--AEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR 220
+ ++ L+ EE E ++ AE R + + Q+ + LQ K E Q
Sbjct: 1519 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1578
Query: 221 DE-LIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGE 279
+ L E+H V + A ++ + + L +RL+
Sbjct: 1579 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1638
Query: 280 KEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFK 339
+++ L+Q K + E ER+ +R G + A Q + E + + RQ++E
Sbjct: 1639 QQKSLAQAEAEKQKEEAERE--ARRRGKAEEQAVRQR----ELAEQELEKQRQLAE---- 1688
Query: 340 LSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEM 399
T +Q ++ E +++R + E E+ L+ E +LQRE A K +E+
Sbjct: 1689 --------GTAQQRLAA-EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1739
Query: 400 EMTNSHLAKRLEKMKANRTALLAQQ 424
E L K++A LLA +
Sbjct: 1740 E-------AELAKVRAEMEVLLASK 1757
Score = 50.8 bits (120), Expect = 2e-06
Identities = 92/442 (20%), Positives = 156/442 (35%), Gaps = 39/442 (8%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKS 64
AS ++T +R E+ RE R A ++A AR+ RELER Q + +E
Sbjct: 1569 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1628
Query: 65 D-KQYAENYTRPSSRNSASA---TTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKD 120
+ AE + S A A + RRG + ++ + + EL L +
Sbjct: 1629 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1688
Query: 121 QIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLK----DVIE 176
Q L L+ + E++ + A+L E + L+ V
Sbjct: 1689 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1748
Query: 177 EQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGT 236
E E +A R EE E+ K + EL E + L E +
Sbjct: 1749 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE--------EAK 1800
Query: 237 PNGDVSHEPVAGAITVVSQEAAQVLESAGEG-----PLDVRLRKLAGEKEELLSQIRKLK 291
++ E A + A+ L + GE ++ L++ E E L
Sbjct: 1801 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1860
Query: 292 LQLEEERQKCSRNDGTVGD-LAGLQNGSDLQF----------IEMQRDANRQISEYKFKL 340
Q ++ +++ + + LA L+ SD + + +R +I K
Sbjct: 1861 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1920
Query: 341 SKAEQDITTLEQSISRLEG---QVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKI- 396
KA LE + R+ LR K AE + +L AE+ + +RE + K
Sbjct: 1921 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1980
Query: 397 ---EEMEMTNSHLAKRLEKMKA 415
EE + +E++KA
Sbjct: 1981 AAEEEAARQRKAALEEVERLKA 2002
Score = 43.1 bits (100), Expect = 5e-04
Identities = 87/429 (20%), Positives = 172/429 (40%), Gaps = 51/429 (11%)
Query: 29 REAEARLAAKRAARAEARDIRMRELE---RQQKELDEKSDK--QYAENYTRPSSRNSASA 83
RE A+L + A D+R RELE RQ + E +D + ++ R R
Sbjct: 1164 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR---RQEQIQ 1220
Query: 84 TTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKE-------L 136
PL+ + + R L L E+ + ++ Q +Y+ +K+
Sbjct: 1221 AMPLADSQAVR-----EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1275
Query: 137 KESLSEVEEKYKKAMVSNA--QLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSK 194
K L V KK V + + E +L L + + + ++E R EE+ +
Sbjct: 1276 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1335
Query: 195 ELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGD----VSHEPVAGAI 250
E+Q+ + + ++ E++ L ++ +L E H + + E V
Sbjct: 1336 LAEQQR---AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1392
Query: 251 TVVS--------QEAAQVLESAGEGPLDVRLRKL-AGEKEELL--SQIRKLKLQLEEERQ 299
V QE Q L + E + + R+ A E+ L +IR ++LQLE +
Sbjct: 1393 AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1452
Query: 300 KCSRNDGTVGDLAGLQNGSDLQFIEMQRDA---NRQISEYKFKLSKAEQDITTLEQSISR 356
+ +G + L ++ Q + Q +A RQ+ + + +AE ++ S +
Sbjct: 1453 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA----SRVK 1508
Query: 357 LEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTA-LDKIEEMEMTNSHLAKRLEKMKA 415
E + R K + A + +EL+ + + +R LR A +++ ++++ + E
Sbjct: 1509 AEAEAAREK---QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1565
Query: 416 NRTALLAQQ 424
++ A A++
Sbjct: 1566 SKRASFAEK 1574
Score = 34.7 bits (78), Expect = 0.17
Identities = 42/221 (19%), Positives = 92/221 (41%), Gaps = 28/221 (12%)
Query: 30 EAEARLAAKRAARAEARDIRMRELERQQKELDE------KSDKQYAENYTRPSSRNSASA 83
EAE + + +A AE +R+ E+ R Q +E K ++ E R
Sbjct: 2355 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2414
Query: 84 TTPLSGNSSRRGSG-DTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSE 142
T + R+ S D L + L ++ + ++ ++ MQ +++ E L +
Sbjct: 2415 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQLLQ 2472
Query: 143 VEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSK---ELERQ 199
+ +++ +S ++ I Q + + + E A+ RE +++ + E ERQ
Sbjct: 2473 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2532
Query: 200 KHMCSV----------------LQHKMEELKEGLRQRDELI 224
+ + S+ Q ++++L++ RQ++EL+
Sbjct: 2533 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2573
Score = 31.6 bits (70), Expect = 1.4
Identities = 52/273 (19%), Positives = 115/273 (42%), Gaps = 28/273 (10%)
Query: 48 IRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDT 107
++ E++RQQ + D + ++ R + A L S + L+
Sbjct: 2417 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL-LQLKSEEMQTVQQEQLLQETQ 2475
Query: 108 SLSELRDIYDLKDQIQDVEGRYMQGLKELKESL-----SEVEEKYKKAMVSNAQLDNEKN 162
+L + KD + E R+++ K E L ++ ++ ++ Q++ E+
Sbjct: 2476 ALQQ--SFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2532
Query: 163 NLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDE 222
L+ ++ + E EE + R +E+ ++LE+Q+ L + E + LR++ +
Sbjct: 2533 RLVASMEEARRRQHEAEEGV----RRKQEELQQLEQQRRQQEEL---LAEENQRLREQLQ 2585
Query: 223 LIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAA---QVLESAGEGPLDVRLRKLAGE 279
L+E+ + + +V+ VA T+ + A E+ E D RK++ +
Sbjct: 2586 LLEEQHRAAL---AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQ 2642
Query: 280 KEELLSQIRKLKLQLEEERQKCSRNDGTVGDLA 312
+ +++ + EE Q+ ++ TV +LA
Sbjct: 2643 R------LQEAGILSAEELQRLAQGHTTVDELA 2669
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 60.1 bits (144), Expect = 4e-09
Identities = 89/434 (20%), Positives = 180/434 (41%), Gaps = 25/434 (5%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDE-K 63
A R+ +R + + S R+AE LA++ A AEA RE +R + L+E +
Sbjct: 1514 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA----AREKQRALQALEELR 1569
Query: 64 SDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGD----TSSLIDPDTSLS-ELRDIYDL 118
+ AE R + A + R + +S + L L++ +
Sbjct: 1570 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1629
Query: 119 KDQIQDVEGRYMQGLKELKESLSEVE---EKYKKAMVSNAQLDNEKNNLIYQVDTLKDVI 175
Q+++ R Q E + + E E E+++ +L + + Q +
Sbjct: 1630 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1689
Query: 176 EEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDG 235
E+Q+E+ R + ++ RQ+ + K +L EG Q+ L + L+ +
Sbjct: 1690 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-RLAAEQELIRLRAE 1748
Query: 236 TPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQ-- 293
T G+ + + + + +EAA + E L+ L K+ E E LL+ + + +
Sbjct: 1749 TEQGEQQRQLLEEELARLQREAAAATQKRQE--LEAELAKVRAEMEVLLASKARAEEESR 1806
Query: 294 --LEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLE 351
E+ +Q+ G +LA + + L+ + + RQ++E +AE + L
Sbjct: 1807 STSEKSKQRLEAEAGRFRELA--EEAARLRALAEEAKRQRQLAEEDAARQRAEAE-RVLA 1863
Query: 352 QSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTN-SHLAKRL 410
+ ++ + G+ R KT AE A K ++ R+L + ++EE + + + +RL
Sbjct: 1864 EKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1922
Query: 411 EKMKANRTALLAQQ 424
+++ + L +Q
Sbjct: 1923 AQLRKASDSELERQ 1936
Score = 58.9 bits (141), Expect = 8e-09
Identities = 91/445 (20%), Positives = 173/445 (38%), Gaps = 64/445 (14%)
Query: 19 AEDEALSNIAREAEARLAAKRAARAEARDIRMR-----ELERQQKELDEKSDKQYAENYT 73
AEDEA E +A A+ A E R ++R ELERQ+ +++ T
Sbjct: 1897 AEDEAFQRRRLEEQA---AQHKADIEERLAQLRKASDSELERQKGLVED----------T 1943
Query: 74 RPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGL 133
R L + + +G ++ S D K+Q + R Q
Sbjct: 1944 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 2003
Query: 134 KELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEE----------QEEQMA 183
E + E EE+ +K++ + + ++ + +V+ LK +EE + +
Sbjct: 2004 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2063
Query: 184 EFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSH 243
+ +E +K + E + H +V Q K +EL++ L+Q ++++ + +
Sbjct: 2064 QLAQEAAQKRLQAEEKAHAFAV-QQKEQELQQTLQQEQSVLDQ-----LRGEAEAARRAA 2117
Query: 244 EPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKL--KLQLEEERQKC 301
E A +EAAQ E RL++ A E+ + +Q + KL+ E E++
Sbjct: 2118 EEAEEARVQAEREAAQSRRQVEEAE---RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2174
Query: 302 SRNDGTVGDLAGLQNGS---------DLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQ 352
R L Q Q + + ++++ + +L + + L++
Sbjct: 2175 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2234
Query: 353 SISRLEGQVLRYKTAAENAEKVEDEL--------KAEKRKLQRELRTALDKIEEMEMTNS 404
+ RL+ + AA +VE+EL + K K + E + + + T
Sbjct: 2235 ELQRLKAEATE---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2291
Query: 405 HLAKRLEKMK-----ANRTALLAQQ 424
L + EKMK A R ++ AQ+
Sbjct: 2292 FLQEEAEKMKQVAEEAARLSVAAQE 2316
Score = 55.8 bits (133), Expect = 7e-08
Identities = 97/458 (21%), Positives = 187/458 (40%), Gaps = 79/458 (17%)
Query: 13 VKDRFSAEDEALSNIAREAE-ARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAEN 71
V D+ E EA A EAE AR+ A+R A R + E ER ++ +E++ +
Sbjct: 2102 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARAQAQ 2159
Query: 72 YTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQ 131
R A ++RR + ++L + +E+ +Q + + Q
Sbjct: 2160 AAAEKLRKEAEQ------EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2213
Query: 132 GLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEE 191
L L+ L E D++KN L ++ LK E Q ++ EE
Sbjct: 2214 ELTTLRLQLEET--------------DHQKNLLDEELQRLKAEATEAARQRSQV----EE 2255
Query: 192 KSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAIT 251
+ + Q S L+ ++E L RD+ + + + V+ E A ++
Sbjct: 2256 ELFSVRVQMEELSKLKARIEAENRALILRDK--DNTQRFLQEEAEKMKQVAEE--AARLS 2311
Query: 252 VVSQEAAQVLESAGEGPLDVRL--RKLAGEKEELLSQIRKLKLQ---------------- 293
V +QEAA++ + A E R K+ EK + + + +LK +
Sbjct: 2312 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2371
Query: 294 -LEEERQKCSRN--DGTVGDLAGLQNGSDLQFIEMQRDANR---QISEYKFKLSKAEQDI 347
L+E++++ ++ + T G L+ Q +EM +A R +++E ++AE+D
Sbjct: 2372 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKLRVAEMSRAQARAEEDA 2430
Query: 348 TTLEQSISRLEGQVLRYKTAAE------------------NAEKVED---ELKAEKRKLQ 386
+ + ++ R + A + +AE++ + EL+ EK KLQ
Sbjct: 2431 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2490
Query: 387 RELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 424
+E + K EEM+ + L++ +A + + L+++
Sbjct: 2491 QEAKLLQLKSEEMQTVQQE--QLLQETQALQQSFLSEK 2526
Score = 54.3 bits (129), Expect = 2e-07
Identities = 83/428 (19%), Positives = 172/428 (40%), Gaps = 43/428 (10%)
Query: 7 GRKRTPVKDRFSAEDEALSNIAR-------------EAEARLAAKRAARAEA---RDIRM 50
GR R+ +D ++++A AR EAE R+ AA EA R +
Sbjct: 1976 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2035
Query: 51 RELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLS 110
E+ER + +++E ++ E + S+R A ++ + L
Sbjct: 2036 EEVERLKAKVEEA--RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2093
Query: 111 E-LRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVD 169
+ L+ + DQ++ + +E +E+ + E ++A S Q++ + +
Sbjct: 2094 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE---REAAQSRRQVE--------EAE 2142
Query: 170 TLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR---DELIEK 226
LK EEQ + A+ E+ KE E++ + + + LRQ+ D +EK
Sbjct: 2143 RLKQSAEEQAQARAQAQAAAEKLRKEAEQE------AARRAQAEQAALRQKQAADAEMEK 2196
Query: 227 HGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQ 286
H V E + + + + L L + A ++ ++ +
Sbjct: 2197 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2256
Query: 287 IRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQD 346
+ +++Q+EE + +R + L + +F++ + + +Q++E +LS A Q+
Sbjct: 2257 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2316
Query: 347 ITTLEQSISR--LEGQVLRYKTAAENAEKVED--ELKAEKRKLQRELRTALDKIEEMEMT 402
L Q + + L K E + V++ LKAE LQ++ A ++ ++
Sbjct: 2317 AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2376
Query: 403 NSHLAKRL 410
+A++L
Sbjct: 2377 KEQMAQQL 2384
Score = 53.5 bits (127), Expect = 4e-07
Identities = 90/445 (20%), Positives = 180/445 (40%), Gaps = 54/445 (12%)
Query: 8 RKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELE----RQQKELDEK 63
++R ++R + + AL + AEA AK A EA++++ R E R++ +D +
Sbjct: 1380 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1439
Query: 64 SDKQYAENYTRPSSRNS-----ASATTPLSGNSSRRGSGDTSSLIDPDTSLSELR----- 113
K+ + + ++S A A + SR + ++ +E +
Sbjct: 1440 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1499
Query: 114 -DIYDLKDQIQDVEGRYMQGLKE---LKESLSEVEEKYKKAMV-------SNAQLDNEKN 162
++ L+ + ++ E + Q +E L+ + + ++ ++A V + A+ EK
Sbjct: 1500 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1559
Query: 163 NLIYQVDTLKDVIEEQEEQM--AEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR 220
+ ++ L+ EE E ++ AE R + + Q+ + LQ K E Q
Sbjct: 1560 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1619
Query: 221 DE-LIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGE 279
+ L E+H V + A ++ + + L +RL+
Sbjct: 1620 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1679
Query: 280 KEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFK 339
+++ L+Q K + E ER+ +R G + A Q + E + + RQ++E
Sbjct: 1680 QQKSLAQAEAEKQKEEAERE--ARRRGKAEEQAVRQR----ELAEQELEKQRQLAE---- 1729
Query: 340 LSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEM 399
T +Q ++ E +++R + E E+ L+ E +LQRE A K +E+
Sbjct: 1730 --------GTAQQRLAA-EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1780
Query: 400 EMTNSHLAKRLEKMKANRTALLAQQ 424
E L K++A LLA +
Sbjct: 1781 E-------AELAKVRAEMEVLLASK 1798
Score = 50.8 bits (120), Expect = 2e-06
Identities = 92/442 (20%), Positives = 156/442 (35%), Gaps = 39/442 (8%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKS 64
AS ++T +R E+ RE R A ++A AR+ RELER Q + +E
Sbjct: 1610 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1669
Query: 65 D-KQYAENYTRPSSRNSASA---TTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKD 120
+ AE + S A A + RRG + ++ + + EL L +
Sbjct: 1670 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1729
Query: 121 QIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLK----DVIE 176
Q L L+ + E++ + A+L E + L+ V
Sbjct: 1730 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1789
Query: 177 EQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGT 236
E E +A R EE E+ K + EL E + L E +
Sbjct: 1790 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE--------EAK 1841
Query: 237 PNGDVSHEPVAGAITVVSQEAAQVLESAGEG-----PLDVRLRKLAGEKEELLSQIRKLK 291
++ E A + A+ L + GE ++ L++ E E L
Sbjct: 1842 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1901
Query: 292 LQLEEERQKCSRNDGTVGD-LAGLQNGSDLQF----------IEMQRDANRQISEYKFKL 340
Q ++ +++ + + LA L+ SD + + +R +I K
Sbjct: 1902 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1961
Query: 341 SKAEQDITTLEQSISRLEG---QVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKI- 396
KA LE + R+ LR K AE + +L AE+ + +RE + K
Sbjct: 1962 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 2021
Query: 397 ---EEMEMTNSHLAKRLEKMKA 415
EE + +E++KA
Sbjct: 2022 AAEEEAARQRKAALEEVERLKA 2043
Score = 43.1 bits (100), Expect = 5e-04
Identities = 87/429 (20%), Positives = 172/429 (40%), Gaps = 51/429 (11%)
Query: 29 REAEARLAAKRAARAEARDIRMRELE---RQQKELDEKSDK--QYAENYTRPSSRNSASA 83
RE A+L + A D+R RELE RQ + E +D + ++ R R
Sbjct: 1205 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR---RQEQIQ 1261
Query: 84 TTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKE-------L 136
PL+ + + R L L E+ + ++ Q +Y+ +K+
Sbjct: 1262 AMPLADSQAVR-----EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1316
Query: 137 KESLSEVEEKYKKAMVSNA--QLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSK 194
K L V KK V + + E +L L + + + ++E R EE+ +
Sbjct: 1317 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1376
Query: 195 ELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGD----VSHEPVAGAI 250
E+Q+ + + ++ E++ L ++ +L E H + + E V
Sbjct: 1377 LAEQQR---AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1433
Query: 251 TVVS--------QEAAQVLESAGEGPLDVRLRKL-AGEKEELL--SQIRKLKLQLEEERQ 299
V QE Q L + E + + R+ A E+ L +IR ++LQLE +
Sbjct: 1434 AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1493
Query: 300 KCSRNDGTVGDLAGLQNGSDLQFIEMQRDA---NRQISEYKFKLSKAEQDITTLEQSISR 356
+ +G + L ++ Q + Q +A RQ+ + + +AE ++ S +
Sbjct: 1494 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA----SRVK 1549
Query: 357 LEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTA-LDKIEEMEMTNSHLAKRLEKMKA 415
E + R K + A + +EL+ + + +R LR A +++ ++++ + E
Sbjct: 1550 AEAEAAREK---QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1606
Query: 416 NRTALLAQQ 424
++ A A++
Sbjct: 1607 SKRASFAEK 1615
Score = 34.7 bits (78), Expect = 0.17
Identities = 42/221 (19%), Positives = 92/221 (41%), Gaps = 28/221 (12%)
Query: 30 EAEARLAAKRAARAEARDIRMRELERQQKELDE------KSDKQYAENYTRPSSRNSASA 83
EAE + + +A AE +R+ E+ R Q +E K ++ E R
Sbjct: 2396 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2455
Query: 84 TTPLSGNSSRRGSG-DTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSE 142
T + R+ S D L + L ++ + ++ ++ MQ +++ E L +
Sbjct: 2456 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQLLQ 2513
Query: 143 VEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSK---ELERQ 199
+ +++ +S ++ I Q + + + E A+ RE +++ + E ERQ
Sbjct: 2514 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2573
Query: 200 KHMCSV----------------LQHKMEELKEGLRQRDELI 224
+ + S+ Q ++++L++ RQ++EL+
Sbjct: 2574 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2614
Score = 31.6 bits (70), Expect = 1.4
Identities = 52/273 (19%), Positives = 115/273 (42%), Gaps = 28/273 (10%)
Query: 48 IRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDT 107
++ E++RQQ + D + ++ R + A L S + L+
Sbjct: 2458 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL-LQLKSEEMQTVQQEQLLQETQ 2516
Query: 108 SLSELRDIYDLKDQIQDVEGRYMQGLKELKESL-----SEVEEKYKKAMVSNAQLDNEKN 162
+L + KD + E R+++ K E L ++ ++ ++ Q++ E+
Sbjct: 2517 ALQQ--SFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2573
Query: 163 NLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDE 222
L+ ++ + E EE + R +E+ ++LE+Q+ L + E + LR++ +
Sbjct: 2574 RLVASMEEARRRQHEAEEGV----RRKQEELQQLEQQRRQQEEL---LAEENQRLREQLQ 2626
Query: 223 LIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAA---QVLESAGEGPLDVRLRKLAGE 279
L+E+ + + +V+ VA T+ + A E+ E D RK++ +
Sbjct: 2627 LLEEQHRAAL---AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQ 2683
Query: 280 KEELLSQIRKLKLQLEEERQKCSRNDGTVGDLA 312
+ +++ + EE Q+ ++ TV +LA
Sbjct: 2684 R------LQEAGILSAEELQRLAQGHTTVDELA 2710
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 59.7 bits (143), Expect = 5e-09
Identities = 93/450 (20%), Positives = 179/450 (39%), Gaps = 81/450 (18%)
Query: 30 EAEARLAAKRAARAEARDIRM---RELERQQKELDEKSDKQYAE---NYTRPSS-----R 78
E E + A+RA+RA+A R RELE + L+E A+ N R + R
Sbjct: 1121 ELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR 1180
Query: 79 NSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIY--------DLKDQIQDV----- 125
+ AT ++ S+ + + L+ + ++K +I D+
Sbjct: 1181 DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNME 1240
Query: 126 -----EGRYMQGLKELKESLSEVEEKYKKAM-------VSNAQLDNEKNNLIYQVDTLKD 173
+G + + L++ LSE++ K ++ A+L E Q+D KD
Sbjct: 1241 TVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDE-KD 1299
Query: 174 VIEEQ--------EEQMAEFYRENEEKSKE-------LERQKHMCSVLQHKMEELKEGLR 218
+ Q +Q+ E R+ EE+ K L+ +H C +L+ + EE +E
Sbjct: 1300 TLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKA 1359
Query: 219 QRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEA----AQVLESAGEG--PLDVR 272
+ + K + T +E A T +EA AQ L+ A E ++ +
Sbjct: 1360 ELQRAMSKANSEVAQWRT-----KYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAK 1414
Query: 273 LRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQ 332
L K+ L +++ L + +E C+ D + QR+ ++
Sbjct: 1415 CASLEKTKQRLQNEVEDLMIDVERTNAACAALD------------------KKQRNFDKI 1456
Query: 333 ISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTA 392
++E+K K + ++ ++ L ++ + K A E + + LK E + LQ+E+
Sbjct: 1457 LAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDL 1516
Query: 393 LDKIEEMEMTNSHLAKRLEKMKANRTALLA 422
++I E L K ++++ ++ L A
Sbjct: 1517 TEQIAEGGKRIHELEKIKKQVEQEKSELQA 1546
Score = 56.2 bits (134), Expect = 5e-08
Identities = 61/275 (22%), Positives = 124/275 (45%), Gaps = 24/275 (8%)
Query: 149 KAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQH 208
K ++ +A+ + E N+ K+ E+ +E++A+ E K KELE + M +++Q
Sbjct: 841 KPLLKSAETEKEMANM-------KEEFEKTKEELAK----TEAKRKELEEK--MVTLMQE 887
Query: 209 KMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGP 268
K + + + D L + D + E +T +++ ++
Sbjct: 888 KNDLQLQVQAEADSLADAEERC---DQLIKTKIQLEAKIKEVTERAEDEEEI-----NAE 939
Query: 269 LDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRD 328
L + RKL E EL I L+L L + ++ + V +L G D ++ ++
Sbjct: 940 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKE 999
Query: 329 ANRQISEYKFKLS--KAEQD-ITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKL 385
++ L +AE+D + TL ++ +LE QV + + E +K+ +L+ KRKL
Sbjct: 1000 KKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKL 1059
Query: 386 QRELRTALDKIEEMEMTNSHLAKRLEKMKANRTAL 420
+ +L+ A + ++E L ++L+K + + L
Sbjct: 1060 EGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGL 1094
Score = 52.4 bits (124), Expect = 8e-07
Identities = 106/499 (21%), Positives = 211/499 (42%), Gaps = 93/499 (18%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAA----RAEARDIRMR-----ELER 55
A+ K + + + DE ++ + +E +A A + +AE + +LE+
Sbjct: 974 ATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQ 1033
Query: 56 QQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELR-D 114
Q +L+ +++ ++ L+ S+ D L D L + +
Sbjct: 1034 QVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQL---DEKLKKKEFE 1090
Query: 115 IYDLKDQIQDVEGRYMQ---GLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTL 171
+ L+ +I+D + MQ +KEL+ + E+EE+ + S A+ + ++++L +++ +
Sbjct: 1091 MSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI 1150
Query: 172 KDVIEE--------------QEEQMAEFYRENEEKSKELE------RQKHMCSV------ 205
+ +EE +E + + R+ EE + + E R+KH SV
Sbjct: 1151 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ 1210
Query: 206 ------LQHKMEELKEGLRQR-DELIEKHGLV------------IIPDGTPNGDVSHEPV 246
++ K+E+ K ++ D+L V + D E
Sbjct: 1211 IDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQ 1270
Query: 247 AGAITVVSQEAAQVLESAGE-----GPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQ-- 299
I ++ + A++ +GE D + +L+ K+ QI +LK QLEEE +
Sbjct: 1271 QRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAK 1330
Query: 300 -------KCSRNDGTVGDLAGLQNGSDLQF-IEMQR---DANRQISEYKFKL-SKAEQDI 347
+ SR+D DL Q + + E+QR AN ++++++ K + A Q
Sbjct: 1331 SALAHALQSSRHD---CDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRT 1387
Query: 348 TTLEQSISRLEGQVLRYKTAAENAEKVEDE---LKAEKRKLQRELRTALDKIEEMEMTNS 404
LE++ +L R + A E+ E V + L+ K++LQ E+ D + ++E TN+
Sbjct: 1388 EELEEAKKKL---AQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVE---DLMIDVERTNA 1441
Query: 405 HLAKRLEKMKANRTALLAQ 423
A L+K + N +LA+
Sbjct: 1442 ACA-ALDKKQRNFDKILAE 1459
Score = 45.8 bits (107), Expect = 7e-05
Identities = 79/388 (20%), Positives = 168/388 (43%), Gaps = 41/388 (10%)
Query: 41 ARAEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSG--NSSRRGSGD 98
A A D + R ++ E +K ++ +AE S + S S +T L N+
Sbjct: 1441 AACAALDKKQRNFDKILAEWKQKCEETHAE--LEASQKESRSLSTELFKIKNAYEESLDQ 1498
Query: 99 TSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMV-SNAQL 157
+L + +L + +I DL +QI + G+ + L+++K+ + + + + + A+ + A L
Sbjct: 1499 LETLKRENKNLQQ--EISDLTEQIAE-GGKRIHELEKIKKQVEQEKSELQAALEEAEASL 1555
Query: 158 DNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQK-HMCSVLQHKMEELKEG 216
++E+ ++ L V E + ++AE K +E+++ K + +++ L
Sbjct: 1556 EHEEGKILRIQLELNQVKSEVDRKIAE-------KDEEIDQMKRNHIRIVESMQSTLDAE 1608
Query: 217 LRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKL 276
+R R++ I + ++H A + + Q + + LD LR
Sbjct: 1609 IRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQ 1668
Query: 277 AGEKEELLSQIRK---LKLQLEEERQKCSRNDGT--VGDLAGLQNGSDLQFIEMQRDANR 331
KE+L R+ L+ ++EE R + + + + + L +Q + Q N
Sbjct: 1669 EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQ---NT 1725
Query: 332 QISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEK------VEDELKAEKRKL 385
+ K KL E IS+++G++ A NAE+ + + AE+ K
Sbjct: 1726 SLINTKKKL----------ETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKK 1775
Query: 386 QRELRTALDKIEE-MEMTNSHLAKRLEK 412
+++ L+++++ +E T L RL++
Sbjct: 1776 EQDTSAHLERMKKNLEQTVKDLQHRLDE 1803
Score = 44.3 bits (103), Expect = 2e-04
Identities = 91/406 (22%), Positives = 168/406 (41%), Gaps = 68/406 (16%)
Query: 48 IRMRELERQQ---KELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSR-RGSGDTSSLI 103
++ E E++ KE EK+ ++ A+ + T N + + + SL
Sbjct: 844 LKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLA 903
Query: 104 DPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNN 163
D + +L +K +IQ +E + +KE+ E + EE NA+L +K
Sbjct: 904 DAEERCDQL-----IKTKIQ-LEAK----IKEVTERAEDEEE-------INAELTAKKRK 946
Query: 164 LIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDEL 223
L + LK I++ E +A ++E++KH ++K++ L E + DE
Sbjct: 947 LEDECSELKKDIDDLELTLA-----------KVEKEKH---ATENKVKNLTEEMAGLDET 992
Query: 224 I-----EKHGLVIIPDGTPNGDVSHEPVAGAIT---VVSQEAAQVLESAGEGPLDVRL-- 273
I EK L T + + E +T + ++ LE + E +R+
Sbjct: 993 IAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDL 1052
Query: 274 ----RKLAGE---KEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNG-SDLQFIEM 325
RKL G+ +E I K QL+E+ +K +++GLQ+ D Q + M
Sbjct: 1053 ERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKK------KEFEMSGLQSKIEDEQALGM 1106
Query: 326 QRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAEN-AEKVEDELKAE--- 381
Q ++I E + ++ + E++I S ++ E Q E +E++E+ A
Sbjct: 1107 Q--LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQ 1164
Query: 382 ---KRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 424
+K + E + +EE + + A L K A+ A L +Q
Sbjct: 1165 IEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ 1210
Score = 36.2 bits (82), Expect = 0.058
Identities = 78/400 (19%), Positives = 151/400 (37%), Gaps = 67/400 (16%)
Query: 24 LSNIAREAEARLAAKRAARAEARDIRMRELERQQKELD-------------EKSDKQYAE 70
L+ + E + ++A K + + +R +E Q LD +K + E
Sbjct: 1569 LNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNE 1628
Query: 71 NYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGR-- 128
+ + N +A + +++ DT +D LR DLK+Q+ VE R
Sbjct: 1629 MEIQLNHANRMAAEALRNYRNTQAILKDTQLHLD-----DALRSQEDLKEQLAMVERRAN 1683
Query: 129 -YMQGLKELKESLSEVEEKYKKAM--------------VSNAQLDNEKNNLIYQVDTLKD 173
++EL+ +L + E K A N L N K L +T
Sbjct: 1684 LLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKL----ETDIS 1739
Query: 174 VIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIP 233
I+ + E + + R EEK+K+ M + K ++ L + + +E+
Sbjct: 1740 QIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQ------- 1792
Query: 234 DGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGP---LDVRLRKLAGEKE-ELLSQIRK 289
D+ H EA Q+ G+ L+ R+R+L GE E E +
Sbjct: 1793 ---TVKDLQHR---------LDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEA 1840
Query: 290 LKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITT 349
+K + ER+ T D + L+ ++ ++ YK + +AE+
Sbjct: 1841 VKGLRKHERKVKELTYQTEEDRKNI-----LRLQDLVDKLQAKVKSYKRQAEEAEEQSNV 1895
Query: 350 LEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQREL 389
R++ ++ + A+ AE ++L+ + R++ ++
Sbjct: 1896 NLSKFRRIQHELEEAEERADIAESQVNKLRVKSREVHTKI 1935
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 59.7 bits (143), Expect = 5e-09
Identities = 89/449 (19%), Positives = 175/449 (38%), Gaps = 79/449 (17%)
Query: 30 EAEARLAAKRAARAEARDIRM---RELERQQKELDEKSDKQYAE---NYTRPSS-----R 78
E E + A+RA+RA+A R RELE + L+E A+ N R + R
Sbjct: 1123 ELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR 1182
Query: 79 NSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELR---------------DIYDLKDQIQ 123
+ AT ++ S+ + + L+ +I DL ++
Sbjct: 1183 DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVE 1242
Query: 124 DV---EGRYMQGLKELKESLSEVEEKYKKAM-------VSNAQLDNEKNNLIYQVDTLKD 173
V +G + + L++ LSE++ K ++ +L E Q+D +
Sbjct: 1243 TVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEA 1302
Query: 174 VIEEQEEQMAEFYRENEEKSKELERQ--------------KHMCSVLQHKMEELKEGLRQ 219
++ + F ++ EE ++LE + +H C +L+ + EE +E +
Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAE 1362
Query: 220 RDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEA----AQVLESAGEG--PLDVRL 273
+ K + T +E A T +EA AQ L++A E ++ +
Sbjct: 1363 LQRALSKANTEVAQWRT-----KYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKC 1417
Query: 274 RKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQI 333
L K+ L +++ L L +E C+ D + QR+ ++ +
Sbjct: 1418 ASLEKTKQRLQNEVEDLMLDVERTNAACAALD------------------KKQRNFDKIL 1459
Query: 334 SEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTAL 393
+E+K K + ++ ++ L ++ + K A E + + LK E + LQ+E+
Sbjct: 1460 AEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLT 1519
Query: 394 DKIEEMEMTNSHLAKRLEKMKANRTALLA 422
++I E L K ++++ + L A
Sbjct: 1520 EQIAEGGKRIHELEKIKKQVEQEKCELQA 1548
Score = 56.2 bits (134), Expect = 5e-08
Identities = 85/428 (19%), Positives = 178/428 (41%), Gaps = 66/428 (15%)
Query: 49 RMRELERQQKELD-EKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDT 107
R+ ELE+ +K+++ EK + Q A S + + ++ S + + D
Sbjct: 1528 RIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDE 1587
Query: 108 SLSELRD----IYDLKDQIQDVEGRYMQGLKELKESLS------EVEEKYKKAMVSNAQL 157
+ +L+ I + D E R LK+ + E++ + M + A L
Sbjct: 1588 EIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEA-L 1646
Query: 158 DNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGL 217
N +N + ++++ + + + R E+ ++L + ++LQ ++EEL+ L
Sbjct: 1647 RNYRNT--------QGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATL 1698
Query: 218 RQRD--------ELIE----------KHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQ 259
Q + EL++ ++ +I D+S + G + + QEA
Sbjct: 1699 EQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQ--MQGEMEDILQEARN 1756
Query: 260 VLESAGEGPLDV-----RLRK-------LAGEKEELLSQIRKLKLQLEEERQ-------- 299
E A + D L+K L K+ + ++ L+L+L+E Q
Sbjct: 1757 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK 1816
Query: 300 KCSRNDGTVGDLAG---LQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISR 356
+ + + V +L G + + + ++ R R++ E ++ + ++I L+ + +
Sbjct: 1817 QIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDK 1876
Query: 357 LEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKAN 416
L+ +V YK AE AE+ + A+ RKLQ EL A E ++ S + K K +
Sbjct: 1877 LQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEA---EERADIAESQVNKLRVKSREV 1933
Query: 417 RTALLAQQ 424
T +++++
Sbjct: 1934 HTKVISEE 1941
Score = 55.8 bits (133), Expect = 7e-08
Identities = 62/268 (23%), Positives = 121/268 (45%), Gaps = 26/268 (9%)
Query: 149 KAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSV-LQ 207
K ++ +A+ + E + + +KD + + E + E EEK L ++K+ + +Q
Sbjct: 843 KPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKEL----EEKMVTLLKEKNDLQLQVQ 898
Query: 208 HKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEG 267
+ E L + + D+LI+ + + I V++ A E E
Sbjct: 899 AEAEGLADAEERCDQLIK----------------TKIQLEAKIKEVTERAEDEEEINAE- 941
Query: 268 PLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQR 327
L + RKL E EL I L+L L + ++ + V +L G D ++ +
Sbjct: 942 -LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTK 1000
Query: 328 DANRQISEYKFKLS--KAEQD-ITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRK 384
+ ++ L +AE+D + TL ++ +LE QV + + E +K+ +L+ KRK
Sbjct: 1001 EKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRK 1060
Query: 385 LQRELRTALDKIEEMEMTNSHLAKRLEK 412
L+ +L+ A + I ++E L ++L+K
Sbjct: 1061 LEGDLKLAQESIMDIENEKQQLDEKLKK 1088
Score = 54.7 bits (130), Expect = 2e-07
Identities = 78/374 (20%), Positives = 156/374 (41%), Gaps = 66/374 (17%)
Query: 49 RMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLID---- 104
+++EL+ + +EL+E+ + + A R+ S G TS+ I+
Sbjct: 1113 KIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKK 1172
Query: 105 PDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNL 164
+ ++R DL++ E K+ +S++E+ E+ +L+ EK+ +
Sbjct: 1173 REAEFQKMR--RDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEM 1230
Query: 165 IYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELI 224
++D L + E SK + MC L+ ++ ELK ++ LI
Sbjct: 1231 KMEIDDLASNV--------------ETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLI 1276
Query: 225 EKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELL 284
D++ + G + S E ++ L+ + + +L+ K+
Sbjct: 1277 --------------NDLTAQ--RGRLQTESGEFSRQLDEK-----EALVSQLSRGKQAFT 1315
Query: 285 SQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDL---QFIEMQRDANRQISEYKFKLS 341
QI +LK QLEEE + L ++ DL Q+ E Q S
Sbjct: 1316 QQIEELKRQLEEE---IKAKNALAHALQSSRHDCDLLREQYEEEQE-------------S 1359
Query: 342 KAEQDITTLEQSISRLEGQVLRYKTAAE-NAEKVEDELKAEKRKLQRELRTALDKIEEME 400
KAE L++++S+ +V +++T E +A + +EL+ K+KL + L+ A + +E +
Sbjct: 1360 KAE-----LQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVN 1414
Query: 401 MTNSHLAKRLEKMK 414
+ L K ++++
Sbjct: 1415 AKCASLEKTKQRLQ 1428
Score = 51.2 bits (121), Expect = 2e-06
Identities = 60/317 (18%), Positives = 128/317 (40%), Gaps = 26/317 (8%)
Query: 118 LKDQIQDVEGRYMQGLK---ELKESLSEVEEKYKKAMVSNAQLDNEKNNLI-------YQ 167
L+ Q+ D+EG Q K +L+ + ++E K A S ++NEK L ++
Sbjct: 1033 LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFE 1092
Query: 168 VDTLKDVIEEQE-------EQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR 220
+ L+ IE+++ +++ E EE +E+E ++ + + + +L L +
Sbjct: 1093 ISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI 1152
Query: 221 DELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQ---EAAQVLESAGEGPLDVRLRKLA 277
E +E+ G G + + A + E A + A L +
Sbjct: 1153 SERLEEAG------GATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1206
Query: 278 GEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYK 337
E E + ++++K +LE+E+ + + + + +M R Q+SE K
Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELK 1266
Query: 338 FKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIE 397
K + ++ I L RL+ + + + E + +L K+ +++ ++E
Sbjct: 1267 SKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLE 1326
Query: 398 EMEMTNSHLAKRLEKMK 414
E + LA L+ +
Sbjct: 1327 EEIKAKNALAHALQSSR 1343
Score = 43.5 bits (101), Expect = 4e-04
Identities = 66/298 (22%), Positives = 126/298 (42%), Gaps = 54/298 (18%)
Query: 112 LRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTL 171
L D + DQ+ + + +KE+ E + EE NA+L +K L + L
Sbjct: 904 LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEE-------INAELTAKKRKLEDECSEL 956
Query: 172 KDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVI 231
K I++ E +A ++E++KH ++K++ L E + DE I K
Sbjct: 957 KKDIDDLELTLA-----------KVEKEKH---ATENKVKNLTEEMAGLDETIAK----- 997
Query: 232 IPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLK 291
+ +H+ + ++ L A ++L + + E L Q +KL+
Sbjct: 998 LTKEKKALQEAHQQTLDDLQ-AEEDKVNTLTKA-----KIKLEQQVDDLEGSLEQEKKLR 1051
Query: 292 LQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDI---- 347
+ LE ++K GDL L S + ++ + ++ + +F++S + I
Sbjct: 1052 MDLERAKRKLE------GDLK-LAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQ 1104
Query: 348 ---TTLEQSISRLEGQV--LRYKTAAENAEKVEDELKAEKRK--LQRELRTALDKIEE 398
L++ I L+ ++ L + AE A + KAEK++ L REL +++EE
Sbjct: 1105 ALGIQLQKKIKELQARIEELEEEIEAERASRA----KAEKQRSDLSRELEEISERLEE 1158
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 59.7 bits (143), Expect = 5e-09
Identities = 89/449 (19%), Positives = 175/449 (38%), Gaps = 79/449 (17%)
Query: 30 EAEARLAAKRAARAEARDIRM---RELERQQKELDEKSDKQYAE---NYTRPSS-----R 78
E E + A+RA+RA+A R RELE + L+E A+ N R + R
Sbjct: 1123 ELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR 1182
Query: 79 NSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELR---------------DIYDLKDQIQ 123
+ AT ++ S+ + + L+ +I DL ++
Sbjct: 1183 DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVE 1242
Query: 124 DV---EGRYMQGLKELKESLSEVEEKYKKAM-------VSNAQLDNEKNNLIYQVDTLKD 173
V +G + + L++ LSE++ K ++ +L E Q+D +
Sbjct: 1243 TVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEA 1302
Query: 174 VIEEQEEQMAEFYRENEEKSKELERQ--------------KHMCSVLQHKMEELKEGLRQ 219
++ + F ++ EE ++LE + +H C +L+ + EE +E +
Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAE 1362
Query: 220 RDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEA----AQVLESAGEG--PLDVRL 273
+ K + T +E A T +EA AQ L++A E ++ +
Sbjct: 1363 LQRALSKANTEVAQWRT-----KYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKC 1417
Query: 274 RKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQI 333
L K+ L +++ L L +E C+ D + QR+ ++ +
Sbjct: 1418 ASLEKTKQRLQNEVEDLMLDVERTNAACAALD------------------KKQRNFDKIL 1459
Query: 334 SEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTAL 393
+E+K K + ++ ++ L ++ + K A E + + LK E + LQ+E+
Sbjct: 1460 AEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLT 1519
Query: 394 DKIEEMEMTNSHLAKRLEKMKANRTALLA 422
++I E L K ++++ + L A
Sbjct: 1520 EQIAEGGKRIHELEKIKKQVEQEKCELQA 1548
Score = 56.2 bits (134), Expect = 5e-08
Identities = 85/428 (19%), Positives = 178/428 (41%), Gaps = 66/428 (15%)
Query: 49 RMRELERQQKELD-EKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDT 107
R+ ELE+ +K+++ EK + Q A S + + ++ S + + D
Sbjct: 1528 RIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDE 1587
Query: 108 SLSELRD----IYDLKDQIQDVEGRYMQGLKELKESLS------EVEEKYKKAMVSNAQL 157
+ +L+ I + D E R LK+ + E++ + M + A L
Sbjct: 1588 EIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEA-L 1646
Query: 158 DNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGL 217
N +N + ++++ + + + R E+ ++L + ++LQ ++EEL+ L
Sbjct: 1647 RNYRNT--------QGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATL 1698
Query: 218 RQRD--------ELIE----------KHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQ 259
Q + EL++ ++ +I D+S + G + + QEA
Sbjct: 1699 EQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQ--MQGEMEDILQEARN 1756
Query: 260 VLESAGEGPLDV-----RLRK-------LAGEKEELLSQIRKLKLQLEEERQ-------- 299
E A + D L+K L K+ + ++ L+L+L+E Q
Sbjct: 1757 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK 1816
Query: 300 KCSRNDGTVGDLAG---LQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISR 356
+ + + V +L G + + + ++ R R++ E ++ + ++I L+ + +
Sbjct: 1817 QIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDK 1876
Query: 357 LEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKAN 416
L+ +V YK AE AE+ + A+ RKLQ EL A E ++ S + K K +
Sbjct: 1877 LQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEA---EERADIAESQVNKLRVKSREV 1933
Query: 417 RTALLAQQ 424
T +++++
Sbjct: 1934 HTKVISEE 1941
Score = 55.8 bits (133), Expect = 7e-08
Identities = 62/268 (23%), Positives = 121/268 (45%), Gaps = 26/268 (9%)
Query: 149 KAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSV-LQ 207
K ++ +A+ + E + + +KD + + E + E EEK L ++K+ + +Q
Sbjct: 843 KPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKEL----EEKMVTLLKEKNDLQLQVQ 898
Query: 208 HKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEG 267
+ E L + + D+LI+ + + I V++ A E E
Sbjct: 899 AEAEGLADAEERCDQLIK----------------TKIQLEAKIKEVTERAEDEEEINAE- 941
Query: 268 PLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQR 327
L + RKL E EL I L+L L + ++ + V +L G D ++ +
Sbjct: 942 -LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTK 1000
Query: 328 DANRQISEYKFKLS--KAEQD-ITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRK 384
+ ++ L +AE+D + TL ++ +LE QV + + E +K+ +L+ KRK
Sbjct: 1001 EKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRK 1060
Query: 385 LQRELRTALDKIEEMEMTNSHLAKRLEK 412
L+ +L+ A + I ++E L ++L+K
Sbjct: 1061 LEGDLKLAQESIMDIENEKQQLDEKLKK 1088
Score = 54.7 bits (130), Expect = 2e-07
Identities = 78/374 (20%), Positives = 156/374 (41%), Gaps = 66/374 (17%)
Query: 49 RMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLID---- 104
+++EL+ + +EL+E+ + + A R+ S G TS+ I+
Sbjct: 1113 KIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKK 1172
Query: 105 PDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNL 164
+ ++R DL++ E K+ +S++E+ E+ +L+ EK+ +
Sbjct: 1173 REAEFQKMR--RDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEM 1230
Query: 165 IYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELI 224
++D L + E SK + MC L+ ++ ELK ++ LI
Sbjct: 1231 KMEIDDLASNV--------------ETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLI 1276
Query: 225 EKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELL 284
D++ + G + S E ++ L+ + + +L+ K+
Sbjct: 1277 --------------NDLTAQ--RGRLQTESGEFSRQLDEK-----EALVSQLSRGKQAFT 1315
Query: 285 SQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDL---QFIEMQRDANRQISEYKFKLS 341
QI +LK QLEEE + L ++ DL Q+ E Q S
Sbjct: 1316 QQIEELKRQLEEE---IKAKNALAHALQSSRHDCDLLREQYEEEQE-------------S 1359
Query: 342 KAEQDITTLEQSISRLEGQVLRYKTAAE-NAEKVEDELKAEKRKLQRELRTALDKIEEME 400
KAE L++++S+ +V +++T E +A + +EL+ K+KL + L+ A + +E +
Sbjct: 1360 KAE-----LQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVN 1414
Query: 401 MTNSHLAKRLEKMK 414
+ L K ++++
Sbjct: 1415 AKCASLEKTKQRLQ 1428
Score = 51.2 bits (121), Expect = 2e-06
Identities = 60/317 (18%), Positives = 128/317 (40%), Gaps = 26/317 (8%)
Query: 118 LKDQIQDVEGRYMQGLK---ELKESLSEVEEKYKKAMVSNAQLDNEKNNLI-------YQ 167
L+ Q+ D+EG Q K +L+ + ++E K A S ++NEK L ++
Sbjct: 1033 LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFE 1092
Query: 168 VDTLKDVIEEQE-------EQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR 220
+ L+ IE+++ +++ E EE +E+E ++ + + + +L L +
Sbjct: 1093 ISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI 1152
Query: 221 DELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQ---EAAQVLESAGEGPLDVRLRKLA 277
E +E+ G G + + A + E A + A L +
Sbjct: 1153 SERLEEAG------GATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1206
Query: 278 GEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYK 337
E E + ++++K +LE+E+ + + + + +M R Q+SE K
Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELK 1266
Query: 338 FKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIE 397
K + ++ I L RL+ + + + E + +L K+ +++ ++E
Sbjct: 1267 SKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLE 1326
Query: 398 EMEMTNSHLAKRLEKMK 414
E + LA L+ +
Sbjct: 1327 EEIKAKNALAHALQSSR 1343
Score = 43.5 bits (101), Expect = 4e-04
Identities = 66/298 (22%), Positives = 126/298 (42%), Gaps = 54/298 (18%)
Query: 112 LRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTL 171
L D + DQ+ + + +KE+ E + EE NA+L +K L + L
Sbjct: 904 LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEE-------INAELTAKKRKLEDECSEL 956
Query: 172 KDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVI 231
K I++ E +A ++E++KH ++K++ L E + DE I K
Sbjct: 957 KKDIDDLELTLA-----------KVEKEKH---ATENKVKNLTEEMAGLDETIAK----- 997
Query: 232 IPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLK 291
+ +H+ + ++ L A ++L + + E L Q +KL+
Sbjct: 998 LTKEKKALQEAHQQTLDDLQ-AEEDKVNTLTKA-----KIKLEQQVDDLEGSLEQEKKLR 1051
Query: 292 LQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDI---- 347
+ LE ++K GDL L S + ++ + ++ + +F++S + I
Sbjct: 1052 MDLERAKRKLE------GDLK-LAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQ 1104
Query: 348 ---TTLEQSISRLEGQV--LRYKTAAENAEKVEDELKAEKRK--LQRELRTALDKIEE 398
L++ I L+ ++ L + AE A + KAEK++ L REL +++EE
Sbjct: 1105 ALGIQLQKKIKELQARIEELEEEIEAERASRA----KAEKQRSDLSRELEEISERLEE 1158
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 59.3 bits (142), Expect = 6e-09
Identities = 69/354 (19%), Positives = 162/354 (45%), Gaps = 37/354 (10%)
Query: 72 YTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQ 131
+T S+R S+ P N +R TSS D S + IY L++Q+ + MQ
Sbjct: 397 FTYYSNRRYLSSANP---NDNR-----TSSNADKSLQESLQKTIYKLEEQLHNE----MQ 444
Query: 132 GLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEE 191
E+++ K K M + N++ NL V ++ + ++ E+ R+ E+
Sbjct: 445 LKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQ 504
Query: 192 KSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAIT 251
++++ ++ S L+ ++E+LK+ + N +++E ++ +
Sbjct: 505 ENEKRRNVENEVSTLKDQLEDLKKV-------------------SQNSQLANEKLS-QLQ 544
Query: 252 VVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDL 311
+EA +L + E VRLRK E + +SQ+ L +L+E R + N + D
Sbjct: 545 KQLEEANDLLRT--ESDTAVRLRKSHTEMSKSISQLESLNRELQE-RNRILENSKSQTDK 601
Query: 312 AGLQNGSDLQFIEMQRDANRQ-ISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAEN 370
Q + L+ R + + I + + +++ ++++ L+ ++ ++EG+ + +
Sbjct: 602 DYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNH 661
Query: 371 AEKVEDELKAEKRKLQRELRTALD-KIEEMEMTNSHLAKRLEKMKANRTALLAQ 423
+EK ++ L+ + + L+ L+ ++ E ++T + L + + ++ ++ + +
Sbjct: 662 SEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCE 715
Score = 54.7 bits (130), Expect = 2e-07
Identities = 89/408 (21%), Positives = 172/408 (42%), Gaps = 40/408 (9%)
Query: 15 DRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQ--QKELDEKSDKQYAENY 72
D+ + +EA S E E +L +R AR +A + R+ ++E+Q ++D K +Q E+
Sbjct: 700 DKHQSIEEAKSVAMCEMEKKLKEEREAREKAEN-RVVQIEKQCSMLDVDLKQSQQKLEHL 758
Query: 73 TRPSSRNS---ASATTPLSGNSSRRGSGDTSSLIDPD--TSLSELRDIYDLKDQIQDVEG 127
T R + T L S++R L+ + T E ++ L+ Q++
Sbjct: 759 TGNKERMEDEVKNLTLQLEQESNKR------LLLQNELKTQAFEADNLKGLEKQMKQEIN 812
Query: 128 RYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYR 187
++ + L+ L+++ ++Y+ +L ++ Y K ++E +E++ E R
Sbjct: 813 TLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNR 872
Query: 188 ENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVA 247
EN +K +EL+ +K + E E + L+E+ + + + + +
Sbjct: 873 ENLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEIT 932
Query: 248 GAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRK----LKLQLEEE----RQ 299
VS+ LE A L + L E EEL +++K KL+ EEE +
Sbjct: 933 DKDHTVSR-----LEEA-NSMLTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKA 986
Query: 300 KCSRNDGT--------VGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLE 351
+N T V LA + N D + ++ AN Q K K ++ Q L
Sbjct: 987 AFEKNINTERTLKTQAVNKLAEIMNRKDFKI--DRKKANTQDLRKKEKENRKLQ--LELN 1042
Query: 352 QSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEM 399
Q + V++++ + + E A + +LQ +L + IE++
Sbjct: 1043 QEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQLASKESDIEQL 1090
Score = 51.6 bits (122), Expect = 1e-06
Identities = 91/423 (21%), Positives = 174/423 (41%), Gaps = 80/423 (18%)
Query: 26 NIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATT 85
N + +ARL K + EA+ + M E+E++ KE E+ ++ AEN + +
Sbjct: 689 NEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKE--EREAREKAENRVVQIEKQCSMLDV 746
Query: 86 PLSGNSSR--RGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEV 143
L + + +G+ + D ++ +L Q++ + + ELK E
Sbjct: 747 DLKQSQQKLEHLTGNKERMED---------EVKNLTLQLEQESNKRLLLQNELKTQAFEA 797
Query: 144 EEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKE----LERQ 199
+ K + Q+ E N L+ K ++E + Q+ + YR NE + +E LE +
Sbjct: 798 DN--LKGL--EKQMKQEINTLL----EAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAE 849
Query: 200 KHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQ 259
++ ++ + +++ELKE + +++ + L I ++ +E A + E
Sbjct: 850 QYFSTLYKTQVKELKEEIEEKN----RENLKKIQ------ELQNEKETLATQLDLAETKA 899
Query: 260 VLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSD 319
E G L+ + +L E ++ S+ RQ+ + D TV L N
Sbjct: 900 ESEQLARGLLEEQYFELTQESKKAASR----------NRQEITDKDHTVSRLEE-ANSML 948
Query: 320 LQFIEMQRDANRQI------SEYKFKLSKAE---------------------QDITTLEQ 352
+ IE+ R N ++ +E ++KL K E Q + L +
Sbjct: 949 TKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAE 1008
Query: 353 SISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEK 412
++R + ++ R K ++ K E E RKLQ EL +K +M + + K L
Sbjct: 1009 IMNRKDFKIDRKKANTQDLRKKE----KENRKLQLELNQEREKFNQMVVKHQ---KELND 1061
Query: 413 MKA 415
M+A
Sbjct: 1062 MQA 1064
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 59.3 bits (142), Expect = 6e-09
Identities = 63/313 (20%), Positives = 132/313 (42%), Gaps = 31/313 (9%)
Query: 117 DLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIE 176
DL+DQI +++ + + ELK L++ EE+ + A+ KNN + V L+ I
Sbjct: 1066 DLQDQIAELQAQ----IDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIA 1121
Query: 177 EQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGL-----RQRDELIEKHGLVI 231
E +E +F E ++K ++++ + L+ EL++ L +Q + +
Sbjct: 1122 ELQE---DFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAE 1178
Query: 232 IPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLK 291
+ +HE I + Q A LE E E L Q ++ K
Sbjct: 1179 LKKALEEETKNHE---AQIQDMRQRHATALE----------------ELSEQLEQAKRFK 1219
Query: 292 LQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLE 351
LE+ +Q ++ + + + ++ + Q+ E K+S+ ++ L
Sbjct: 1220 ANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELA 1279
Query: 352 QSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLE 411
+ S+L+ ++ T E AEK + + L+ +L+ + ++E +L+ R+
Sbjct: 1280 EKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIR 1339
Query: 412 KMKANRTALLAQQ 424
+++ + +L QQ
Sbjct: 1340 QLEEEKNSLQEQQ 1352
Score = 58.9 bits (141), Expect = 8e-09
Identities = 85/415 (20%), Positives = 177/415 (42%), Gaps = 65/415 (15%)
Query: 21 DEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKS-----DKQYAENYTRP 75
+EA + ++AEA L+ + +A A D + R Q+ELD+ + +Q A N +
Sbjct: 1391 EEAKKKLLKDAEA-LSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKK 1449
Query: 76 SSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLS----ELRDIYDLKDQIQDVEGRYM- 130
+ L+ + S+S E RD + + + ++ + +
Sbjct: 1450 QKK--------------------FDQLLAEEKSISARYAEERDRAEAEAREKETKALSLA 1489
Query: 131 QGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNL---IYQVDTLKDVIEEQEEQMAEFYR 187
+ L+E E+ E E + K+ L + K+++ +++++ K +E+Q E+M
Sbjct: 1490 RALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLE 1549
Query: 188 ENEEKSKELERQKHMCSVLQHKME-ELKEGLRQRDELIE-KHGLVIIPDGTPNGDVSHEP 245
E E++ + E K V M+ + + L+ RDE E K L+I ++ E
Sbjct: 1550 ELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDER 1609
Query: 246 VAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRND 305
A+ V S++ ++ L+ ++ ++E++ Q+RKL+ Q+++ ++
Sbjct: 1610 KQRALAVASKKKMEI----DLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR------ 1659
Query: 306 GTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYK 365
+L+ RD E + ++E+ + +LE I +L+ ++ +
Sbjct: 1660 -------------ELEEARASRD------EIFAQSKESEKKLKSLEAEILQLQEELASSE 1700
Query: 366 TAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTAL 420
A +AE+ DEL E LD+ +E + L + LE+ ++N L
Sbjct: 1701 RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELL 1755
Score = 55.1 bits (131), Expect = 1e-07
Identities = 62/313 (19%), Positives = 140/313 (44%), Gaps = 40/313 (12%)
Query: 110 SELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVD 169
++++ + + Q ++++ + + LK +KE ++VE + ++ + QL EKN L Q+
Sbjct: 839 TKVKPLLQVTRQEEELQAKDEELLK-VKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQ 897
Query: 170 TLKDVIEEQEEQMAEFYRENEEKSKEL-------ERQKHMCSVLQHKMEELKEGLRQRDE 222
++ E EE A + +E + L E ++ +LQ++ ++++ ++ +E
Sbjct: 898 AETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE 957
Query: 223 LIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEE 282
+++ +G + A A +E +LE K EK+
Sbjct: 958 QLDEE------EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNS--------KFIKEKKL 1003
Query: 283 LLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSK 342
+ +I + QL EE +K +LA ++N ++ IS+ + +L K
Sbjct: 1004 MEDRIAECSSQLAEEEEKAK-------NLAKIRNKQEVM-----------ISDLEERLKK 1045
Query: 343 AEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMT 402
E+ LE++ +L+G+ + + DELK + K + EL+ AL + ++ +
Sbjct: 1046 EEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLH 1105
Query: 403 NSHLAKRLEKMKA 415
++ K + +++A
Sbjct: 1106 KNNALKVVRELQA 1118
Score = 55.1 bits (131), Expect = 1e-07
Identities = 84/401 (20%), Positives = 157/401 (39%), Gaps = 30/401 (7%)
Query: 20 EDEALSNIAREAEARLAAK-RAARAE-ARDIRMRELERQQKELDEKSDKQYAENYTRPSS 77
EDE + +A+ RL +A +A+ RD++ R+ + ++K+ KQ E
Sbjct: 1552 EDELQAT--EDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKK--RLLIKQVRELEAELED 1607
Query: 78 RNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSE--LRDIYDLKDQIQDVEGRYMQGLKE 135
A S D + I+ + ++ + L+ Q++D + +
Sbjct: 1608 ERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARAS 1667
Query: 136 LKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKE 195
E ++ +E KK A++ + L + +E++E E KS
Sbjct: 1668 RDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSAL 1727
Query: 196 LERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQ 255
L+ ++ + + + EEL+E + L ++ + T N +++ E A S
Sbjct: 1728 LDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQ---KSD 1784
Query: 256 EAAQVLESAGEGPLDVRLRKLAGE-KEELLSQIRKLKL---QLEEERQKCSRNDGTVGDL 311
A Q LE + L +L++L G K + + I L+ QLEE+ ++ ++ L
Sbjct: 1785 NARQQLERQNK-ELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKL 1843
Query: 312 AGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENA 371
+ D R +YK ++ KA + L++ + E A
Sbjct: 1844 VRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQL--------------EEA 1889
Query: 372 EKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEK 412
E+ A +RKLQREL A + E + S L RL +
Sbjct: 1890 EEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRR 1930
Score = 48.9 bits (115), Expect = 9e-06
Identities = 62/271 (22%), Positives = 119/271 (43%), Gaps = 26/271 (9%)
Query: 167 QVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEK 226
+V L V ++EE A K +EL + K + ++ ++EE++ R+ +L+E+
Sbjct: 840 KVKPLLQVTRQEEELQA--------KDEELLKVKEKQTKVEGELEEME---RKHQQLLEE 888
Query: 227 HGLVIIP-DGTPNGDVSHEPVAGAITVVSQEAAQVL---ESAGEGPLDVRLRKLAGEKEE 282
++ E + + QE ++L ES E + R + L EK++
Sbjct: 889 KNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEE-EERNQILQNEKKK 947
Query: 283 LLSQIRKLKLQLEEE---RQKCSRNDGT-------VGDLAGLQNGSDLQFIEMQRDANRQ 332
+ + I+ L+ QL+EE RQK T + + L + +FI+ ++ +
Sbjct: 948 MQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDR 1007
Query: 333 ISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTA 392
I+E +L++ E+ L + ++ E + + + EK EL+ KRKL E
Sbjct: 1008 IAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDL 1067
Query: 393 LDKIEEMEMTNSHLAKRLEKMKANRTALLAQ 423
D+I E++ L +L K + LA+
Sbjct: 1068 QDQIAELQAQIDELKLQLAKKEEELQGALAR 1098
Score = 46.2 bits (108), Expect = 6e-05
Identities = 78/402 (19%), Positives = 162/402 (40%), Gaps = 40/402 (9%)
Query: 50 MRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDP--DT 107
+++++ + + +K D Q E + + S + + + + S+L++
Sbjct: 1243 LQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKK 1302
Query: 108 SLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNA-QLDNEKNNLIY 166
+ +D L+ Q+QD + L + E + K + S QL+ EKN+L
Sbjct: 1303 GIKFAKDAASLESQLQDTQ------------ELLQEETRQKLNLSSRIRQLEEEKNSLQE 1350
Query: 167 QVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEK 226
Q + ++ + E+Q+ + + K+++ L+ ++L + + +E+
Sbjct: 1351 QQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEE 1410
Query: 227 HGLVIIP-DGTPNG----------DVSHE-PVAGAITVVSQEAAQVLE-----SAGEGPL 269
L + T N D+ H+ VA + ++ Q+L SA
Sbjct: 1411 KALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEE 1470
Query: 270 DVRLRKLAGEKE-ELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSD------LQF 322
R A EKE + LS R L+ LE + + +N D+ L + D +
Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHEL 1530
Query: 323 IEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEK 382
+ +R +Q+ E + +L + E ++ E + RLE + K E + DE EK
Sbjct: 1531 EKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEK 1590
Query: 383 RKLQ-RELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQ 423
++L +++R ++E+ + +KM+ + L AQ
Sbjct: 1591 KRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQ 1632
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.125 0.323
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,285,542
Number of Sequences: 37866
Number of extensions: 661600
Number of successful extensions: 11804
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 333
Number of HSP's successfully gapped in prelim test: 905
Number of HSP's that attempted gapping in prelim test: 5537
Number of HSP's gapped (non-prelim): 4434
length of query: 424
length of database: 18,247,518
effective HSP length: 105
effective length of query: 319
effective length of database: 14,271,588
effective search space: 4552636572
effective search space used: 4552636572
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.