Search of human proteins with 195972900

Search of human proteins with 195972900

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|195972900 thromboxane A synthase 1, platelet isoform TXS-II
[Homo sapiens]
         (460 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|195972900 thromboxane A synthase 1, platelet isoform TXS-II [...   933   0.0  
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H...   925   0.0  
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H...   925   0.0  
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   250   2e-66
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...   246   3e-65
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   246   4e-65
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   240   2e-63
gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide ...   239   4e-63
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...   237   1e-62
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...    94   3e-19
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...    92   1e-18
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...    88   1e-17
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                   87   3e-17
gi|5729796 cytochrome P450, family 46 [Homo sapiens]                   87   3e-17
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...    84   3e-16
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...    83   5e-16
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...    82   1e-15
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8...    82   1e-15
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ...    82   1e-15
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide...    81   2e-15
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ...    81   2e-15
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ...    79   1e-14
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ...    79   1e-14
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ...    75   1e-13
gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide...    75   2e-13
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ...    74   2e-13
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide...    74   3e-13
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1...    72   1e-12
gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide...    72   1e-12
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11...    72   1e-12

>gi|195972900 thromboxane A synthase 1, platelet isoform TXS-II
           [Homo sapiens]
          Length = 460

 Score =  933 bits (2412), Expect = 0.0
 Identities = 460/460 (100%), Positives = 460/460 (100%)

Query: 1   MMEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFF 60
           MMEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFF
Sbjct: 1   MMEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFF 60

Query: 61  RQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKS 120
           RQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKS
Sbjct: 61  RQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKS 120

Query: 121 VADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ 180
           VADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ
Sbjct: 121 VADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ 180

Query: 181 RCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPL 240
           RCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPL
Sbjct: 181 RCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPL 240

Query: 241 ARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDI 300
           ARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDI
Sbjct: 241 ARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDI 300

Query: 301 VRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLAT 360
           VRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLAT
Sbjct: 301 VRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLAT 360

Query: 361 NPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCE 420
           NPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCE
Sbjct: 361 NPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCE 420

Query: 421 VLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERYRCS 460
           VLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERYRCS
Sbjct: 421 VLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERYRCS 460


>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  925 bits (2390), Expect = 0.0
 Identities = 456/457 (99%), Positives = 457/457 (100%)

Query: 1   MMEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFF 60
           MMEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFF
Sbjct: 1   MMEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFF 60

Query: 61  RQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKS 120
           RQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKS
Sbjct: 61  RQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKS 120

Query: 121 VADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ 180
           VADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ
Sbjct: 121 VADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ 180

Query: 181 RCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPL 240
           RCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPL
Sbjct: 181 RCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPL 240

Query: 241 ARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDI 300
           ARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDI
Sbjct: 241 ARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDI 300

Query: 301 VRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLAT 360
           VRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLAT
Sbjct: 301 VRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLAT 360

Query: 361 NPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCE 420
           NPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCE
Sbjct: 361 NPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCE 420

Query: 421 VLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERY 457
           VLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPER+
Sbjct: 421 VLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERF 457


>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  925 bits (2390), Expect = 0.0
 Identities = 456/457 (99%), Positives = 457/457 (100%)

Query: 1   MMEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFF 60
           MMEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFF
Sbjct: 1   MMEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFF 60

Query: 61  RQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKS 120
           RQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKS
Sbjct: 61  RQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKS 120

Query: 121 VADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ 180
           VADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ
Sbjct: 121 VADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ 180

Query: 181 RCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPL 240
           RCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPL
Sbjct: 181 RCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPL 240

Query: 241 ARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDI 300
           ARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDI
Sbjct: 241 ARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDI 300

Query: 301 VRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLAT 360
           VRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLAT
Sbjct: 301 VRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLAT 360

Query: 361 NPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCE 420
           NPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCE
Sbjct: 361 NPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCE 420

Query: 421 VLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERY 457
           VLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPER+
Sbjct: 421 VLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERF 457


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  250 bits (638), Expect = 2e-66
 Identities = 155/449 (34%), Positives = 240/449 (53%), Gaps = 45/449 (10%)

Query: 16  MVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLY 75
           M T  L    L LL  Y T +    +KLG+  P P PF+GN+  + +GF    ME  K Y
Sbjct: 9   METWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKY 68

Query: 76  GPLCGYYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASG-LEFKSVADSVLFLRDKRW 133
           G + G+Y G++  + I++PDMIK VLV E +S FTNR   G + F   A S+    D+ W
Sbjct: 69  GKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIA--EDEEW 126

Query: 134 EEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVAS 193
           + +R  L   F+  KL EMVP+I+Q  D+L+ +L+R AE+G    ++  +  Y+ DV+ S
Sbjct: 127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186

Query: 194 VAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARIL-----PNKN 248
            +FG  +DS   P+DPFV++ K+   F    P  + +  FP  ++P+  +L     P   
Sbjct: 187 TSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFP-FLIPILEVLNICVFPR-- 243

Query: 249 RDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSST 308
             E+  F  K ++ +   R  +  ++ R DFLQ+++D+++S                   
Sbjct: 244 --EVTNFLRKSVKRMKESR-LEDTQKHRVDFLQLMIDSQNS------------------- 281

Query: 309 GCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKL 368
                     + +   + L+  E+V Q+ IF+ AGYE  ++ LSF  Y LAT+PD Q+KL
Sbjct: 282 ----------KETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKL 331

Query: 369 LREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPA 428
             E+D        P + ++ + + YLDMV+ ETLR++P A R  R   +D E+ G  IP 
Sbjct: 332 QEEIDAVLPNKAPPTYDTVLQ-MEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPK 390

Query: 429 GAVLEMAVGALHHDPEHWPSPETFNPERY 457
           G V+ +   ALH DP++W  PE F PER+
Sbjct: 391 GVVVMIPSYALHRDPKYWTEPEKFLPERF 419


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score =  246 bits (628), Expect = 3e-65
 Identities = 148/438 (33%), Positives = 237/438 (54%), Gaps = 34/438 (7%)

Query: 21  LSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCG 80
           L+V+L+ LL  Y T      +KLG+  P P PF+GN   FR+G+W   ME  K Y  + G
Sbjct: 15  LAVSLI-LLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDMECYKKYRKVWG 73

Query: 81  YYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGA 139
            Y  ++  + I++PDMIK VLV E +S FTNR   G     + +++    D+ W+ +R  
Sbjct: 74  IYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFG-PVGFMKNAISIAEDEEWKRIRSL 132

Query: 140 LMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTP 199
           L   F+  KL EMVP+I+Q  D+L+ +L+R AE+G    ++  +  Y+ DV+ S +FG  
Sbjct: 133 LSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVS 192

Query: 200 VDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKL 259
           +DS   P+DPFV++ K+   F    P ++ +  FP +   L  +       ++  F  K 
Sbjct: 193 IDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKS 252

Query: 260 IRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQ 319
           ++ +   R ++  ++ R DFLQ+++D+++S                             +
Sbjct: 253 VKQIKEGRLKE-TQKHRVDFLQLMIDSQNS-----------------------------K 282

Query: 320 PSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKH 379
            S   + L+  E++ Q+ IF+ AGYE  ++ LSF  Y LAT+PD Q+K+ +E+D      
Sbjct: 283 DSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNK 342

Query: 380 MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGAL 439
             P + ++ + L YLDMV+ ETLR++P A R  R   +D E+ G  IP G V+ +    L
Sbjct: 343 APPTYDTVLQ-LEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVL 401

Query: 440 HHDPEHWPSPETFNPERY 457
           HHDP++W  PE F PER+
Sbjct: 402 HHDPKYWTEPEKFLPERF 419


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  246 bits (627), Expect = 4e-65
 Identities = 148/445 (33%), Positives = 237/445 (53%), Gaps = 41/445 (9%)

Query: 18  TVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGP 77
           T  L    L LL  Y T      ++LG+  P P P +GN+  +RQG W+   E  K YG 
Sbjct: 11  TWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGK 70

Query: 78  LCGYYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEV 136
           + G Y G+   + I++PD+I+ VLV E +S FTNR + G     +  ++    D+ W+ +
Sbjct: 71  MWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLG-PVGFMKSAISLAEDEEWKRI 129

Query: 137 RGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAF 196
           R  L   F+  KL EM P+I+Q  D+L+ +L+R AE G    ++  +  Y+ DV+   +F
Sbjct: 130 RSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSF 189

Query: 197 GTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNK--NRDELNG 254
           G  +DS   P+DPFV+  K+F +F    P+ + ++ FP  + P+   L      +D +N 
Sbjct: 190 GVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFP-FLTPVFEALNVSLFPKDTIN- 247

Query: 255 FFNKLIRNV--IALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKP 312
           F +K +  +    L D+Q   + R DFLQ+++D+++S                       
Sbjct: 248 FLSKSVNRMKKSRLNDKQ---KHRLDFLQLMIDSQNS----------------------- 281

Query: 313 NPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV 372
                 + +   + L+  E+  Q+ IF+ AGYE  ++ LSF  Y LAT+PD Q+KL +E+
Sbjct: 282 ------KETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEI 335

Query: 373 DVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVL 432
           D        P + ++ + + YLDMV+ ETLR++P A R  R   +D E+ G  IP G+++
Sbjct: 336 DAVLPNKAPPTYDAVVQ-MEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMV 394

Query: 433 EMAVGALHHDPEHWPSPETFNPERY 457
            +   ALHHDP++W  PE F PER+
Sbjct: 395 VIPTYALHHDPKYWTEPEEFRPERF 419


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  240 bits (613), Expect = 2e-63
 Identities = 148/448 (33%), Positives = 230/448 (51%), Gaps = 37/448 (8%)

Query: 13  NGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELR 72
           N  M T  L    L LL  Y T +    +KLG+  P P PF+G + F+ +G W    E  
Sbjct: 6   NFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECN 65

Query: 73  KLYGPLCGYYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASGLEFKSVADSVLFLRDK 131
           + YG + G Y G++  +VI +PDMIK VLV E +S FTN+M  G     +  ++ F  D+
Sbjct: 66  EKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLG-PMGFLKSALSFAEDE 124

Query: 132 RWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVV 191
            W+ +R  L  AF+  K  EMVP+ISQ  D+L+  L++ AE+  + +++  +  YT DV+
Sbjct: 125 EWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184

Query: 192 ASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDE 251
               FG  +DS   P+DPF+K+ K+  +     P L+L+  FP +      +       +
Sbjct: 185 TGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKD 244

Query: 252 LNGFFNKLIRNV--IALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTG 309
           +  F    I  +    L+D+Q   + R DF Q ++D+++S                    
Sbjct: 245 VTHFLKNSIERMKESRLKDKQ---KHRVDFFQQMIDSQNSKE------------------ 283

Query: 310 CKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLL 369
                ++ H      + L+  E+V Q+ I + A Y+  + TL F  Y LAT+PD Q+KL 
Sbjct: 284 -----TKSH------KALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQ 332

Query: 370 REVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAG 429
            E+D          + +L + + YLDMV+ ETLR++P   R TR   +D E+ G  IP G
Sbjct: 333 EEIDAVLPNKAPVTYDALVQ-MEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKG 391

Query: 430 AVLEMAVGALHHDPEHWPSPETFNPERY 457
             + + + ALHHDP++W  PE F PER+
Sbjct: 392 LAVMVPIYALHHDPKYWTEPEKFCPERF 419


>gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 3 [Homo sapiens]
          Length = 420

 Score =  239 bits (610), Expect = 4e-63
 Identities = 148/447 (33%), Positives = 229/447 (51%), Gaps = 37/447 (8%)

Query: 13  NGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELR 72
           N  M T  L    L LL  Y T +    +KLG+  P P PF+G + F+ +G W    E  
Sbjct: 6   NFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECN 65

Query: 73  KLYGPLCGYYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASGLEFKSVADSVLFLRDK 131
           + YG + G Y G++  +VI +PDMIK VLV E +S FTN+M  G     +  ++ F  D+
Sbjct: 66  EKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLG-PMGFLKSALSFAEDE 124

Query: 132 RWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVV 191
            W+ +R  L  AF+  K  EMVP+ISQ  D+L+  L++ AE+  + +++  +  YT DV+
Sbjct: 125 EWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184

Query: 192 ASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDE 251
               FG  +DS   P+DPF+K+ K+  +     P L+L+  FP +      +       +
Sbjct: 185 TGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKD 244

Query: 252 LNGFFNKLIRNV--IALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTG 309
           +  F    I  +    L+D+Q   + R DF Q ++D+++S                    
Sbjct: 245 VTHFLKNSIERMKESRLKDKQ---KHRVDFFQQMIDSQNSKE------------------ 283

Query: 310 CKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLL 369
                ++ H      + L+  E+V Q+ I + A Y+  + TL F  Y LAT+PD Q+KL 
Sbjct: 284 -----TKSH------KALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQ 332

Query: 370 REVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAG 429
            E+D          + +L + + YLDMV+ ETLR++P   R TR   +D E+ G  IP G
Sbjct: 333 EEIDAVLPNKAPVTYDALVQ-MEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKG 391

Query: 430 AVLEMAVGALHHDPEHWPSPETFNPER 456
             + + + ALHHDP++W  PE F PER
Sbjct: 392 LAVMVPIYALHHDPKYWTEPEKFCPER 418


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score =  237 bits (605), Expect = 1e-62
 Identities = 147/446 (32%), Positives = 228/446 (51%), Gaps = 37/446 (8%)

Query: 13  NGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELR 72
           N  M T  L    L LL  Y T +    +KLG+  P P PF+G + F+ +G W    E  
Sbjct: 6   NFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECN 65

Query: 73  KLYGPLCGYYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASGLEFKSVADSVLFLRDK 131
           + YG + G Y G++  +VI +PDMIK VLV E +S FTN+M  G     +  ++ F  D+
Sbjct: 66  EKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLG-PMGFLKSALSFAEDE 124

Query: 132 RWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVV 191
            W+ +R  L  AF+  K  EMVP+ISQ  D+L+  L++ AE+  + +++  +  YT DV+
Sbjct: 125 EWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184

Query: 192 ASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDE 251
               FG  +DS   P+DPF+K+ K+  +     P L+L+  FP +      +       +
Sbjct: 185 TGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKD 244

Query: 252 LNGFFNKLIRNV--IALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTG 309
           +  F    I  +    L+D+Q   + R DF Q ++D+++S                    
Sbjct: 245 VTHFLKNSIERMKESRLKDKQ---KHRVDFFQQMIDSQNSKE------------------ 283

Query: 310 CKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLL 369
                ++ H      + L+  E+V Q+ I + A Y+  + TL F  Y LAT+PD Q+KL 
Sbjct: 284 -----TKSH------KALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQ 332

Query: 370 REVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAG 429
            E+D          + +L + + YLDMV+ ETLR++P   R TR   +D E+ G  IP G
Sbjct: 333 EEIDAVLPNKAPVTYDALVQ-MEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKG 391

Query: 430 AVLEMAVGALHHDPEHWPSPETFNPE 455
             + + + ALHHDP++W  PE F PE
Sbjct: 392 LAVMVPIYALHHDPKYWTEPEKFCPE 417


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 103/467 (22%), Positives = 196/467 (41%), Gaps = 52/467 (11%)

Query: 9   KLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPS-----PFIGNLTFFR-- 61
           KL + G    ++L+ A L L      ++++R  K     P P+     P +G+    +  
Sbjct: 12  KLLLWGAASALSLAGASLVLSLLQRVASYAR--KWQQMRPIPTVARAYPLVGHALLMKPD 69

Query: 62  -QGFWESQMELRKLYG--PLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEF 118
            + F++  +E  + Y   PL   ++G    + +   + ++ +L  +     + M   LE 
Sbjct: 70  GREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLE- 128

Query: 119 KSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFD 178
             +   +L     +W   R  L   F    L + + ++++  ++L+  L+++    +AF+
Sbjct: 129 PWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQ-EAFN 187

Query: 179 IQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMV 238
                     D++   A G  + +    +  +V+   R  E    R      +  P + +
Sbjct: 188 CFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRR------IKMPWLWL 241

Query: 239 PLARIL------PNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASP 292
            L  ++        K+   L+ F N +I       +  A E+ R D        R SA  
Sbjct: 242 DLWYLMFKEGWEHKKSLQILHTFTNSVIAE--RANEMNANEDCRGD-------GRGSAPS 292

Query: 293 MGVQD--FDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNT 350
              +    D++  V    G +               L+ ++I  +   F+  G++     
Sbjct: 293 KNKRRAFLDLLLSVTDDEGNR---------------LSHEDIREEVDTFMFEGHDTTAAA 337

Query: 351 LSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFR 410
           ++++ YLL +NP+ Q+K+  E+D    K   P      + L YL+ VI ETLR++P    
Sbjct: 338 INWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPL 397

Query: 411 FTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERY 457
           F R  ++DCEV G R+  G    +   ALH DP ++P+PE F PER+
Sbjct: 398 FARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERF 444


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 115/455 (25%), Positives = 195/455 (42%), Gaps = 57/455 (12%)

Query: 15  PMVTVALSVALLALLK-WYSTSAFSRLEKLGLRHPKPSPFIGN-LTFFRQGFWESQMELR 72
           P V + L ++ L LL  W  +S   +L       P P P IGN L    +   +S   L 
Sbjct: 3   PFVVLVLCLSCLLLLSIWRQSSGRGKLPP----GPTPLPVIGNILQIDIKDVSKSLTNLS 58

Query: 73  KLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGL-EFKSVADSVLFLRDK 131
           K+YGP+   Y G    +V+   +++K+ L++    F+ R    L E  +    ++F   K
Sbjct: 59  KIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGK 118

Query: 132 RWEEVRG-ALMSA--FSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCY-CNYT 187
           RW+E+R  +LM+   F   K +    +  +A  L+    K  A   D   I  C  CN  
Sbjct: 119 RWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCN-- 176

Query: 188 TDVVASVAFGTPVDSWQAPEDPFVKHCKRFFE--FCIPRPILVLLLSFPSIMVPLARILP 245
             V+ S+ F    D     +  F+   ++  E    +  P + +  +FP+I+        
Sbjct: 177 --VICSIIFQKRFD---YKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTII-------- 223

Query: 246 NKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVF 305
               D   G  NKL++N+  +           D L+ V + + S       D +  RD  
Sbjct: 224 ----DYFPGTHNKLLKNLAFMES---------DILEKVKEHQES------MDINNPRDFI 264

Query: 306 SSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQ 365
                K    +Q+Q S      T++ +V  A   L AG E  + TL +A  LL  +P+  
Sbjct: 265 DCFLIKMEKEKQNQQS----EFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVT 320

Query: 366 EKLLREVDVFKEKHMAPEFCSLEEG-LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ 424
            K+  E++    ++ +P  C  + G +PY D V+ E  R Y      +   A  C+V  +
Sbjct: 321 AKVQEEIERVIGRNRSP--CMQDRGHMPYTDAVVHEVQR-YIDLIPTSLPHAVTCDVKFR 377

Query: 425 R--IPAGAVLEMAVGALHHDPEHWPSPETFNPERY 457
              IP G  +  ++ ++ HD + +P+PE F+P  +
Sbjct: 378 NYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHF 412


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 103/422 (24%), Positives = 174/422 (41%), Gaps = 62/422 (14%)

Query: 52  PFIGNLTFFRQGFWESQMELR---KLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNF 108
           PF+GN  FF   F +S +E++   K YG L    LG    ++I+   +IK+ L+    NF
Sbjct: 51  PFLGN--FFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNF 108

Query: 109 TNRMASGLE---FKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNE--MVPLISQACDLL 163
            NR  + +    FK   + ++    + W+E R   ++A     L +  +   I +    L
Sbjct: 109 GNRPVTPMREHIFKK--NGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHL 166

Query: 164 LAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPV---DSWQAPEDPFVKHCKRFFE- 219
              +K   E+G  FD      N  ++++ S+ FG      DSW      F +  K   E 
Sbjct: 167 TEAIKE--ENGQPFDPHFKINNAVSNIICSITFGERFEYQDSW------FQQLLKLLDEV 218

Query: 220 -FCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRD 278
            +        L   FP IM    + LP  ++   + +        + L      ++ R+D
Sbjct: 219 TYLEASKTCQLYNVFPWIM----KFLPGPHQTLFSNW------KKLKLFVSHMIDKHRKD 268

Query: 279 FLQMVLDARHSASPMGVQDF--DIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQA 336
           +           +P   +DF    ++++   TG   NP+              + ++   
Sbjct: 269 W-----------NPAETRDFIDAYLKEMSKHTG---NPTSSFHE---------ENLICST 305

Query: 337 FIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDM 396
                AG E  + TL +A   +A  P+ QEK+  E+D    +   P   +  E +PY + 
Sbjct: 306 LDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAA-RESMPYTNA 364

Query: 397 VIAETLRMYPPA-FRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPE 455
           VI E  RM         RE   D  + G  +P G ++   + ALH DP  W +P+TFNP+
Sbjct: 365 VIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPD 424

Query: 456 RY 457
            +
Sbjct: 425 HF 426


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 112/463 (24%), Positives = 189/463 (40%), Gaps = 74/463 (15%)

Query: 19  VALSVALLALLKWYSTSAFSRLEKLGLRHPKPS---PFIGNLTFF-RQGFWESQM-ELRK 73
           VAL +  LA L W       +    G ++PK     P +G+L F  R G   +   +L+K
Sbjct: 5   VALLLLTLAYLFW------PKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQK 58

Query: 74  LYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNR-MASGLEFKSVADSVLFLRDK- 131
            YGP+    +G +  +++    + K+VL++   +F+ R   + L+  S     +   D  
Sbjct: 59  KYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSG 118

Query: 132 -RWEEVRGALMSAFS-----PEKLNEMV-PLISQACDLLLAHLKRYAESGDAFDIQRCYC 184
             W+  R   M+ F+      +KL +++   IS  CD+L  H      +G + DI     
Sbjct: 119 AHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATH------NGQSIDISFPVF 172

Query: 185 NYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSI--MVPLAR 242
              T+V++ + F T   +     DP +   + + E  I        LS  S+  +VP  +
Sbjct: 173 VAVTNVISLICFNTSYKN----GDPELNVIQNYNEGIIDN------LSKDSLVDLVPWLK 222

Query: 243 ILPNKNRDEL-------NGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGV 295
           I PNK  ++L       N   NK++ N          E+ R D +  +LD          
Sbjct: 223 IFPNKTLEKLKSHVKIRNDLLNKILENY--------KEKFRSDSITNMLDT--------- 265

Query: 296 QDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFAT 355
               +++   +S      P    Q S +     +   +G  F    AG E  T+ + +  
Sbjct: 266 ----LMQAKMNSDNGNAGPD---QDSELLSDNHILTTIGDIF---GAGVETTTSVVKWTL 315

Query: 356 YLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPA-FRFTRE 414
             L  NP  ++KL  E+D        P   S    L  L+  I E LR+ P A      +
Sbjct: 316 AFLLHNPQVKKKLYEEIDQNVGFSRTPTI-SDRNRLLLLEATIREVLRLRPVAPMLIPHK 374

Query: 415 AAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERY 457
           A  D  +    +  G  + + + ALHH+ + W  P+ F PER+
Sbjct: 375 ANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERF 417


>gi|5729796 cytochrome P450, family 46 [Homo sapiens]
          Length = 500

 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 96/435 (22%), Positives = 171/435 (39%), Gaps = 80/435 (18%)

Query: 48  PKPSPFIGNLTFFRQGFWESQ-----------MELRKLYGPLCGYYLGRRMFIVISEPDM 96
           P+PS  +G+L  F    W+             ++  K YGP+    +  +  ++++ P+ 
Sbjct: 37  PRPSFLLGHLPCF----WKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPES 92

Query: 97  IKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD-------KRWEEVRGALMSAFSPEKL 149
           +K+ L+    N  ++M   L+  +V    LF +        +RW + R  +  AFS   L
Sbjct: 93  VKKFLMSTKYNKDSKMYRALQ--TVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSL 150

Query: 150 NEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDP 209
             ++   ++  + L+  L+  A+      +Q        D++A  AFG         + P
Sbjct: 151 VSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKP 210

Query: 210 FVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRD-----ELNGFFNKLIRNVI 264
                       + + + ++L    +    LA+ LP K +      E   F  ++ R+ +
Sbjct: 211 ------------LSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWV 258

Query: 265 ALRDQ--QAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSP 322
             R +  +  EE   D L  +L A       G QD + + D F +               
Sbjct: 259 QRRREALKRGEEVPADILTQILKAEE-----GAQDDEGLLDNFVT--------------- 298

Query: 323 MARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAP 382
                           F IAG+E   N L+F    L+  P+   +L  EVD         
Sbjct: 299 ----------------FFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYL 342

Query: 383 EFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHD 442
           +F  L   L YL  V+ E+LR+YPPA+   R   ++  + G R+P    L  +   +   
Sbjct: 343 DFEDLGR-LQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRM 401

Query: 443 PEHWPSPETFNPERY 457
             ++  P TFNP+R+
Sbjct: 402 DTYFEDPLTFNPDRF 416


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 102/484 (21%), Positives = 188/484 (38%), Gaps = 72/484 (14%)

Query: 5   LGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRH-PKPSPFIGNL------ 57
           LG L+L+ +G  +   L   L+ALL W   S   R    G+   P P P +GN       
Sbjct: 25  LGLLRLDPSGGAL---LLCGLVALLGW---SWLRRRRARGIPPGPTPWPLVGNFGHVLLP 78

Query: 58  TFFRQGFWESQM------------------ELRKLYGPLCGYYLGRRMFIVISEPDMIKQ 99
            F R+  W S                     L ++YG +  +++G  + +V+S+   +++
Sbjct: 79  PFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVRE 138

Query: 100 VLVENFSNFTNRMASGL-EFKSVADSVLFLR-DKRWEEVRG---ALMSAFSPEKLNEMVP 154
            LV+    F++R    L    +    V+F      W + R    + +  F   KL+ + P
Sbjct: 139 ALVQQAEVFSDRPRVPLISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLS-LEP 197

Query: 155 LISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHC 214
            I +    + A ++++ E  D F       N  ++++ S+ FG   D   +     +   
Sbjct: 198 KIIEEFKYVKAEMQKHGE--DPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFM 255

Query: 215 KRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEE 274
            R  E C+   +L++ +      +P     P K   ++       ++ +I    +    E
Sbjct: 256 SRGLEICLNSQVLLVNICPWLYYLPFG---PFKELRQIEKDITSFLKKIIKDHQESLDRE 312

Query: 275 RRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVG 334
             +DF+ M L                               R++  +       +  I+G
Sbjct: 313 NPQDFIDMYL-------------------------LHMEEERKNNSNSSFDEEYLFYIIG 347

Query: 335 QAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYL 394
             FI   AG +  TN+L +    ++ NPD QEK+  E++     + AP      + +PY 
Sbjct: 348 DLFI---AGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQ-MPYT 403

Query: 395 DMVIAETLRMYPPA-FRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFN 453
           +  I E  R+            +++  + G  IP G ++   + ++H DP  W  PE F 
Sbjct: 404 EATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFY 463

Query: 454 PERY 457
           P R+
Sbjct: 464 PNRF 467


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 101/455 (22%), Positives = 177/455 (38%), Gaps = 57/455 (12%)

Query: 15  PMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGN-LTFFRQGFWESQMELRK 73
           P V + L ++ + L   +  S   R    G   P P P IGN L    +   +S     K
Sbjct: 3   PFVVLVLCLSFMLLFSLWRQSCRRRKLPPG---PTPLPIIGNMLQIDVKDICKSFTNFSK 59

Query: 74  LYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVAD-SVLFLRDKR 132
           +YGP+   Y G    +V    + +K+ L++N   F+ R  S +  +      ++    KR
Sbjct: 60  VYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKR 119

Query: 133 WEEVRGALMSAFSPEKLNE--MVPLISQACDLLLAHLKRYAES--GDAFDIQRCYCNYTT 188
           W+E+R   ++      + +  +   + +    L+  L++   S     F +    CN   
Sbjct: 120 WKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCN--- 176

Query: 189 DVVASVAFGTPVDSWQAPEDPFVKHCKRFFEF--CIPRPILVLLLSFPSIMVPLARILPN 246
            V+ SV F    D     +  F+   KRF E    +  P + +  +FP ++         
Sbjct: 177 -VICSVVFQKRFDY---KDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLI--------- 223

Query: 247 KNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFS 306
              D   G  NK+++NV   R     + +            H AS     D +  RD   
Sbjct: 224 ---DCFPGTHNKVLKNVALTRSYIREKVKE-----------HQAS----LDVNNPRDFID 265

Query: 307 STGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQE 366
               K    + +Q S       ++ +VG      +AG E  + TL +   LL  +P+   
Sbjct: 266 CFLIKMEQEKDNQKSEF----NIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTA 321

Query: 367 KLLREVDVFKEKHMAPEFCSLEEG-LPYLDMVIAETLR---MYPPAFRFTREAAQDCEVL 422
           K+  E+D    +H +P  C  +   +PY D V+ E  R   + P           D +  
Sbjct: 322 KVQEEIDHVIGRHRSP--CMQDRSHMPYTDAVVHEIQRYSDLVPTG--VPHAVTTDTKFR 377

Query: 423 GQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERY 457
              IP G  +   + ++ HD + +P+P  F+P  +
Sbjct: 378 NYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHF 412


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 112/457 (24%), Positives = 193/457 (42%), Gaps = 63/457 (13%)

Query: 16  MVTVALSVALLALLK-WYSTSAFSRLEKLGLRHPKPSPFIGN-LTFFRQGFWESQMELRK 73
           +V + L ++ L LL  W  +S   +L       P P P IGN L    +   +S   L K
Sbjct: 4   LVVLVLCLSCLLLLSLWRQSSGRGKLPP----GPTPLPVIGNILQIGIKDISKSLTNLSK 59

Query: 74  LYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGL-EFKSVADSVLFLRDKR 132
           +YGP+   Y G +  +V+   + +K+ L++    F+ R    L E  +    ++F   K+
Sbjct: 60  VYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKK 119

Query: 133 WEEVRG-ALMSA--FSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCY-CNYTT 188
           W+E+R  +LM+   F   K +    +  +A  L+    K  A   D   I  C  CN   
Sbjct: 120 WKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCN--- 176

Query: 189 DVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMV-----PLARI 243
            V+ S+ F    D     +  F+   ++  E        + +LS P I +     P+   
Sbjct: 177 -VICSIIFHKRFDY---KDQQFLNLMEKLNEN-------IKILSSPWIQICNNFSPIIDY 225

Query: 244 LPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRD 303
            P        G  NKL++NV  ++            L+ V + + S      QDF    D
Sbjct: 226 FP--------GTHNKLLKNVAFMKSY---------ILEKVKEHQESMDMNNPQDFI---D 265

Query: 304 VFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPD 363
            F     K    + +QPS      T++ +   A     AG E  + TL +A  LL  +P+
Sbjct: 266 CFLM---KMEKEKHNQPSEF----TIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPE 318

Query: 364 CQEKLLREVDVFKEKHMAPEFCSLEEG-LPYLDMVIAETLRMYPPAFRFTREAAQDCEVL 422
              K+  E++    ++ +P  C  +   +PY D V+ E  R Y      +   A  C++ 
Sbjct: 319 VTAKVQEEIERVIGRNRSP--CMQDRSHMPYTDAVVHEVQR-YIDLLPTSLPHAVTCDIK 375

Query: 423 GQR--IPAGAVLEMAVGALHHDPEHWPSPETFNPERY 457
            +   IP G  + +++ ++ HD + +P+PE F+P  +
Sbjct: 376 FRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHF 412


>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
           [Homo sapiens]
          Length = 520

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 85/352 (24%), Positives = 143/352 (40%), Gaps = 53/352 (15%)

Query: 121 VADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDA-FDI 179
           + D +L     +W   R  L  AF    L   + + S++ +++ A  +R A  G    D+
Sbjct: 132 LGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDV 191

Query: 180 QRCYCNYTTDVVASVAFGTPVDSWQAPEDPF----------VKHCKRFFEFCIPRPILVL 229
                  T D +    F    +  + P +            VK   +FF +         
Sbjct: 192 FEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFFRY--------- 242

Query: 230 LLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHS 289
              F   + P  R             F++  R V    D    E RR    Q V D   +
Sbjct: 243 -KDFLYFLTPCGRR------------FHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQA 289

Query: 290 ASPMGVQDF-DIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIIT 348
            +     DF D++       G               + L+ ++I  +A  F+  G++   
Sbjct: 290 KAKSKTLDFIDVLLLSEDKNG---------------KELSDEDIRAEADTFMFGGHDTTA 334

Query: 349 NTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAP-EFCSLEEGLPYLDMVIAETLRMYP 406
           + LS+  Y LA +P+ QE+  +EV ++ K++     E+  L + LP+L M + E+LR++P
Sbjct: 335 SGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQ-LPFLTMCLKESLRLHP 393

Query: 407 PAFRFTREAAQDCEVLGQR-IPAGAVLEMAVGALHHDPEHWPSPETFNPERY 457
           P   F R   QD  +   R IP G V  + + A+HH+P  WP PE ++P R+
Sbjct: 394 PIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRF 445


>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 1 [Homo sapiens]
          Length = 490

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 105/455 (23%), Positives = 187/455 (41%), Gaps = 57/455 (12%)

Query: 15  PMVTVALSVALLALLK-WYSTSAFSRLEKLGLRHPKPSPFIGN-LTFFRQGFWESQMELR 72
           P V + L ++ L LL  W  +S   RL       P P P IGN L    +   +S     
Sbjct: 3   PAVALVLCLSCLFLLSLWRQSSGRGRLPS----GPTPLPIIGNILQLDVKDMSKSLTNFS 58

Query: 73  KLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFK-SVADSVLFLRDK 131
           K+YGP+   Y G +  +V+   + +K+ L+++   F+ R +  +  K +    +LF   K
Sbjct: 59  KVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGK 118

Query: 132 RWEEVRGALMSA---FSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCY-CNYT 187
           RW+E+R   +     F   K +    +  +A  L+    K  A   D   I  C  CN  
Sbjct: 119 RWKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCN-- 176

Query: 188 TDVVASVAFGTPVDSWQAPEDPFVKHCKRFFE--FCIPRPILVLLLSFPSIMVPLARILP 245
             V+ SV F    D +   +  F+   ++F E    +  P + +  +FP+++        
Sbjct: 177 --VICSVIFH---DRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALI-------- 223

Query: 246 NKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVF 305
               D L G  NK+  N   ++            L+ + + + S       D +  RD  
Sbjct: 224 ----DYLPGSHNKIAENFAYIKSY---------VLERIKEHQESL------DMNSARDFI 264

Query: 306 SSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQ 365
                K    + +Q S      TV+ ++        AG E  + TL +   LL   P+  
Sbjct: 265 DCFLIKMEQEKHNQQS----EFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVT 320

Query: 366 EKLLREVDVFKEKHMAPEFCSLEEG-LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ 424
            K+  E++    ++ +P  C  +   +PY D V+ E ++ Y          A  C+V  +
Sbjct: 321 AKVQEEIECVVGRNRSP--CMQDRSHMPYTDAVVHE-IQRYIDLLPTNLPHAVTCDVKFK 377

Query: 425 R--IPAGAVLEMAVGALHHDPEHWPSPETFNPERY 457
              IP G  +  ++ ++ H+ + +P+PE F+P  +
Sbjct: 378 NYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHF 412


>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
           [Homo sapiens]
          Length = 520

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 105/430 (24%), Positives = 179/430 (41%), Gaps = 59/430 (13%)

Query: 48  PKPSPFIGNLTFFR---QGFWESQMELRKLYGPLCGYYLGRRMFIV-ISEPDMIKQVLVE 103
           PK + F+G+L       +G   +Q  L   +G +C +++G    IV I  P  IK VL  
Sbjct: 55  PKRNWFLGHLGLIHSSEEGLLYTQ-SLACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFA 113

Query: 104 NFSNFTNRMASGLEFKS-VADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDL 162
             +            K  + D +L    ++W   R  L  AF    L   + + +++ ++
Sbjct: 114 PAAIVPKDKVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNI 173

Query: 163 LLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCI 222
           + A  +  A  G A            D+   ++  T +DS Q     F  HC+       
Sbjct: 174 MHAKWQLLASEGSA----------RLDMFEHISLMT-LDSLQKCVFSFDSHCQEK----- 217

Query: 223 PRPILVLLLSFPSIMVP-----------LARILPNKNRDELNGFFNKLIRNVIALRDQQA 271
           P   +  +L   +++             L  + P+  R      F +  R V    D   
Sbjct: 218 PSEYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQR------FRRACRLVHDFTDAVI 271

Query: 272 AEERRRDFLQMVLDARHSASPMGVQDF-DIVRDVFSSTGCKPNPSRQHQPSPMARPLTVD 330
            E RR    Q V D   + +     DF D++       G K               L+ +
Sbjct: 272 QERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKK---------------LSDE 316

Query: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAP-EFCSLE 388
           +I  +A  F+  G++   + LS+  Y LA +P+ QE+  +EV ++ K++     E+  L 
Sbjct: 317 DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLA 376

Query: 389 EGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL-GQRIPAGAVLEMAVGALHHDPEHWP 447
           + LP+L M I E+LR++PP    +R   QD  +  G+ IP G +  ++V   HH+P  WP
Sbjct: 377 Q-LPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWP 435

Query: 448 SPETFNPERY 457
            PE ++P R+
Sbjct: 436 DPEVYDPFRF 445


>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
           [Homo sapiens]
          Length = 516

 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 103/456 (22%), Positives = 172/456 (37%), Gaps = 58/456 (12%)

Query: 21  LSVALLALLKWYSTSAFSRLEKLGLRHPKPS---PFIGNLTFFRQGFWESQMELRKLYGP 77
           L+ A+  L+ W       R+ K GL+ P      P +G++    +    +   + + YG 
Sbjct: 16  LASAIFCLVFWVLKGLRPRVPK-GLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGD 74

Query: 78  LCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRM----------ASGLEFKSVADSVLF 127
           +    +G    +V+S  D I+Q LV    +F  R              L F + +  V  
Sbjct: 75  VLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWA 134

Query: 128 LRDKRWEEVRGALMSAFSPEKLNE--MVPLISQACDLLLAHLKRYAESGDAFDIQRCYCN 185
            R +  +        A  P   +   +   +S+    L++ L+        FD       
Sbjct: 135 ARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVV 194

Query: 186 YTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILP 245
              +V+ ++ FG     +    D  +   K   EF     +       P    P+ R LP
Sbjct: 195 SVANVIGAMCFG---QHFPESSDEMLSLVKNTHEF-----VETASSGNPLDFFPILRYLP 246

Query: 246 NKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFD--IVRD 303
           N                  AL+  +A  +R   FLQ  +   +       QDFD   VRD
Sbjct: 247 NP-----------------ALQRFKAFNQRFLWFLQKTVQEHY-------QDFDKNSVRD 282

Query: 304 VFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPD 363
           +   TG     S++  P      +  ++IV        AG++ +T  +S++   L T P+
Sbjct: 283 I---TGALFKHSKKG-PRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPE 338

Query: 364 CQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLR--MYPPAFRFTREAAQDCEV 421
            Q K+ +E+D    +   P      + LPYL+  I ET R   + P F       +D  +
Sbjct: 339 IQRKIQKELDTVIGRERRPRLSDRPQ-LPYLEAFILETFRHSSFLP-FTIPHSTTRDTTL 396

Query: 422 LGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERY 457
            G  IP    + +    ++HDPE W  P  F PER+
Sbjct: 397 NGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERF 432


>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
           [Homo sapiens]
          Length = 491

 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 101/447 (22%), Positives = 174/447 (38%), Gaps = 43/447 (9%)

Query: 17  VTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFF-RQGFWESQMELRKLY 75
           ++ A+ + LLAL+    T +     KL    P+P   +GNL     Q    S  +L K Y
Sbjct: 4   ISTAILLLLLALVCLLLTLSSRDKGKLP-PGPRPLSILGNLLLLCSQDMLTSLTKLSKEY 62

Query: 76  GPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFK-SVADSVLFLRDKRWE 134
           G +   +LG R  +V+S    +K+ LV+    F+ R      F  +  + + F    RW+
Sbjct: 63  GSMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWK 122

Query: 135 EVRG---ALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVV 191
            +R     ++  F   K +    ++ +    LLA L++    G+ FD         ++++
Sbjct: 123 VLRQFSIQILRNFGMGKRSIEERILEEG-SFLLAELRK--TEGEPFDPTFVLSRSVSNII 179

Query: 192 ASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDE 251
            SV FG+  D         ++     F+  +  P   L   FPS++            D 
Sbjct: 180 CSVLFGSRFDYDDERLLTIIRLINDNFQI-MSSPWGELYDIFPSLL------------DW 226

Query: 252 LNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCK 311
           + G   ++ +N   LRD  A           V D + S  P   +DF           C 
Sbjct: 227 VPGPHQRIFQNFKCLRDLIA---------HSVHDHQASLDPRSPRDF---------IQCF 268

Query: 312 PNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLRE 371
                + +  P++    +D ++      L  G + ++ TL  A   L   P  Q ++  E
Sbjct: 269 LTKMAEEKEDPLSH-FHMDTLLMTTHNLLFGGTKTVSTTLHHAFLALMKYPKVQARVQEE 327

Query: 372 VDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPA-FRFTREAAQDCEVLGQRIPAGA 430
           +D+   +   P        +PY D VI E  R              +D    G  IP G 
Sbjct: 328 IDLVVGRARLPALKD-RAAMPYTDAVIHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGT 386

Query: 431 VLEMAVGALHHDPEHWPSPETFNPERY 457
            +   +  +H+DP  + +P+ FNPE +
Sbjct: 387 DVITLLNTVHYDPSQFLTPQEFNPEHF 413


>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
           [Homo sapiens]
          Length = 509

 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 99/457 (21%), Positives = 185/457 (40%), Gaps = 67/457 (14%)

Query: 21  LSVALLALLKWYSTSAFSRLEKLGLRHPKPSP----FIGNLTFFRQGFWESQMELRKLYG 76
           L++ LL  +K Y      R   L    P P+P    F+G+  F +    E   E+ + Y 
Sbjct: 22  LALGLLQAIKLY----LRRQRLLRDLRPFPAPPTHWFLGHQKFIQDDNMEKLEEIIEKYP 77

Query: 77  PLCGYYLGR-RMFIVISEPDMIKQVL--VENFSNFTNRMASGLEFKSVADSVLFLRDKRW 133
               +++G  + F  I +PD  K +L   +  S +  + +  L  K +A     L   +W
Sbjct: 78  RAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAA----LDGPKW 133

Query: 134 EEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGD-AFDIQRCYCNYTTDVVA 192
            + R  L   F    L   + +++ +  ++L   ++   + D + ++     + + D++ 
Sbjct: 134 FQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIM 193

Query: 193 SVAFGTPVD-SWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNR-D 250
             AF    +    +  DP+ K      +    R  L  LL    I+  L+   P   R  
Sbjct: 194 KCAFSKETNCQTNSTHDPYAKAIFELSKIIFHR--LYSLLYHSDIIFKLS---PQGYRFQ 248

Query: 251 ELNGFFNKLIRNVI---------ALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIV 301
           +L+   N+    +I          ++     + + +DFL +VL A+   S     D D+ 
Sbjct: 249 KLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDE-SGSSFSDIDVH 307

Query: 302 RDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATN 361
            +V +                                FL+AG++ +  ++S+  Y LA N
Sbjct: 308 SEVST--------------------------------FLLAGHDTLAASISWILYCLALN 335

Query: 362 PDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEV 421
           P+ QE+   EV        +  +  L E + Y  M I ET R+ P     +R+ ++    
Sbjct: 336 PEHQERCREEVRGILGDGSSITWDQLGE-MSYTTMCIKETCRLIPAVPSISRDLSKPLTF 394

Query: 422 L-GQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERY 457
             G  +PAG  + +++  LHH+P  W +P+ F+P R+
Sbjct: 395 PDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRF 431


>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
           [Homo sapiens]
          Length = 493

 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 106/450 (23%), Positives = 177/450 (39%), Gaps = 50/450 (11%)

Query: 17  VTVALSV---ALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFR-QGFWESQMELR 72
           VTVAL V    LL +  W    +   L       P P P IGNL     +   +S   L 
Sbjct: 6   VTVALLVWAAFLLLVSMWRQVHSSWNLPP----GPFPLPIIGNLFQLELKNIPKSFTRLA 61

Query: 73  KLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRDKR 132
           + +GP+   Y+G +  +V+     +K+ L++    F+ R             ++F     
Sbjct: 62  QRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPT 121

Query: 133 WEEVRGALMSAFSPEKLNEM--VPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDV 190
           W+++R   ++      + +      I +    LL  L++    G  FD          +V
Sbjct: 122 WKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRK--TQGQPFDPTFLIGCAPCNV 179

Query: 191 VASVAFGTPVDSWQAPEDPFVKHCKRFFE--FCIPRPILVLLLSFPSIMVPLARILPNKN 248
           +A + F    D     ++ F++    F E    +  P L L  +FPS +      LP  +
Sbjct: 180 IADILFRKHFDY---NDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFL----HYLPGSH 232

Query: 249 RDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSST 308
           R        K+I+NV  +++     ER ++  Q +             D +  RD+   T
Sbjct: 233 R--------KVIKNVAEVKEY--VSERVKEHHQSL-------------DPNCPRDL---T 266

Query: 309 GCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKL 368
            C      + + S   R  T+D I         AG E  + TL +   +L   P+ +EKL
Sbjct: 267 DCLLVEMEKEKHSA-ERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKL 325

Query: 369 LREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPA-FRFTREAAQDCEVLGQRIP 427
             E+D        P     +E +PY+D V+ E  R           EA +D    G  IP
Sbjct: 326 HEEIDRVIGPSRIPAIKDRQE-MPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIP 384

Query: 428 AGAVLEMAVGALHHDPEHWPSPETFNPERY 457
            G V+   + ++ +D + +P PE F PE +
Sbjct: 385 KGTVVVPTLDSVLYDNQEFPDPEKFKPEHF 414


>gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22
           [Homo sapiens]
          Length = 531

 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 87/374 (23%), Positives = 161/374 (43%), Gaps = 33/374 (8%)

Query: 89  IVISEPDMIKQVLVENFSNFT-NRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPE 147
           +V+  PD IK +L  + +    + +  G     + D +L  +  +W   R  L  AF  +
Sbjct: 107 LVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFD 166

Query: 148 KLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPE 207
            L   + + +Q+ D++ A  +  AE G A  +         D+   ++  T +DS Q   
Sbjct: 167 ILKPYMKIFNQSADIMHAKWRHLAE-GSAVSL---------DMFEHISLMT-LDSLQKCV 215

Query: 208 DPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALR 267
             +  +C+      I   I +  LS       L   L        +G   +   +++   
Sbjct: 216 FSYNSNCQEKMSDYISAIIELSALSVRR-QYRLHHYLDFIYYRSADGRRFRQACDMVHHF 274

Query: 268 DQQAAEERRRDFLQMVLDARHSASPMGVQDF-DIVRDVFSSTGCKPNPSRQHQPSPMARP 326
             +  +ERRR   Q   +A   A      DF D++       G               + 
Sbjct: 275 TTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDG---------------KE 319

Query: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAP-EF 384
           L+ ++I  +A  F+  G++  ++ +S+  + LA  P+ QEK   E+ +V K + +   E+
Sbjct: 320 LSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEW 379

Query: 385 CSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL-GQRIPAGAVLEMAVGALHHDP 443
             L + LP+  M I E+LR YPP    +R+  +D ++  G+ IP G +  +++   HH+P
Sbjct: 380 DDLTQ-LPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNP 438

Query: 444 EHWPSPETFNPERY 457
             WP  + +NP R+
Sbjct: 439 TVWPDSKVYNPYRF 452


>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
           [Homo sapiens]
          Length = 520

 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 42/135 (31%), Positives = 75/135 (55%), Gaps = 2/135 (1%)

Query: 325 RPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAPE 383
           + L+ ++I  +A  F+  G++   + LS+  Y LA +P+ QE+  +EV ++ K++     
Sbjct: 311 KKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEI 370

Query: 384 FCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL-GQRIPAGAVLEMAVGALHHD 442
                  LP+L M + E+LR++PP    +R   QD  +  G+ IP G +  ++V   HH+
Sbjct: 371 EWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHN 430

Query: 443 PEHWPSPETFNPERY 457
           P  WP PE ++P R+
Sbjct: 431 PAVWPDPEVYDPFRF 445


>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
           [Homo sapiens]
          Length = 524

 Score = 73.9 bits (180), Expect = 3e-13
 Identities = 88/383 (22%), Positives = 162/383 (42%), Gaps = 48/383 (12%)

Query: 88  FIVISEPDMIKQVLVENFSNFTNRMAS-------GLEFKS--VADSVLFLRDKRWEEVRG 138
           FIV+  PD I+ +        TN  A+        + F    + + +L     +W   R 
Sbjct: 98  FIVLCHPDTIRSI--------TNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRR 149

Query: 139 ALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGT 198
            L  AF    L   + + +++ +++L   +  A  G +            D+   ++  T
Sbjct: 150 MLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSS----------RLDMFEHISLMT 199

Query: 199 PVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNK 258
            +DS Q     F  HC+        RP       + + ++ L+ ++  +++  L      
Sbjct: 200 -LDSLQKCIFSFDSHCQE-------RPS-----EYIATILELSALVEKRSQHILQHMDFL 246

Query: 259 LIRNVIALRDQQAAEERRRDFLQMVLDARHSASP-MGVQDFDIVRDVFSSTGCKPNPSRQ 317
              +    R  +A      DF   V+  R    P  G+ DF   +D   S          
Sbjct: 247 YYLSHDGRRFHRACR-LVHDFTDAVIRERRRTLPTQGIDDF--FKDKAKSKTLDFIDVLL 303

Query: 318 HQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFK 376
                  + L+ ++I  +A  F+  G++   + LS+  Y LA +P+ QE+  +EV ++ K
Sbjct: 304 LSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLK 363

Query: 377 EKHMAP-EFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL-GQRIPAGAVLEM 434
           ++     E+  L + LP+L M + E+LR++PPA   +R   QD  +  G+ IP G    +
Sbjct: 364 DRDPKEIEWDDLAQ-LPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLI 422

Query: 435 AVGALHHDPEHWPSPETFNPERY 457
            +  +HH+P  WP PE ++P R+
Sbjct: 423 DIIGVHHNPTVWPDPEVYDPFRF 445


>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 97/455 (21%), Positives = 177/455 (38%), Gaps = 54/455 (11%)

Query: 21  LSVALLALLKWYSTSAFSRLEKLGLRHPKPS---PFIGNLTFFRQGFWESQMELRKLYGP 77
           L+  +  L+ W   ++  ++ K GL++P      P IG++    +    +   + + YG 
Sbjct: 14  LASVIFCLVFWVIRASRPQVPK-GLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGD 72

Query: 78  LCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNR--------MASGLEFKSVADSVLFLR 129
           +    +G    +V+S  D I+Q LV    +F  R        +++G       DS     
Sbjct: 73  VLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWA 132

Query: 130 DKRWEEVRGALMSAFSPEKLNE----MVPLISQACDLLLAHLKRYAESGDAFDIQRCYCN 185
            +R     G    + + +  +     +   +S+  ++L++ L+        F+  R    
Sbjct: 133 ARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVV 192

Query: 186 YTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILP 245
             T+V+ ++ FG   D         V     F E        V+    P+  +P+ R LP
Sbjct: 193 SVTNVICAICFGRRYDHNHQELLSLVNLNNNFGE--------VVGSGNPADFIPILRYLP 244

Query: 246 NKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVF 305
           N +   LN F              +   E+   F+Q ++   +     G      +RD+ 
Sbjct: 245 NPS---LNAF--------------KDLNEKFYSFMQKMVKEHYKTFEKGH-----IRDIT 282

Query: 306 SSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLI-AGYEIITNTLSFATYLLATNPDC 364
            S        ++ Q    A     DE +    + L  AG++ +T  +S++   L  NP  
Sbjct: 283 DSL---IEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRV 339

Query: 365 QEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLR--MYPPAFRFTREAAQDCEVL 422
           Q K+  E+D    +   P   S    LPY++  I ET R   + P F       +D  + 
Sbjct: 340 QRKIQEELDTVIGRSRRPRL-SDRSHLPYMEAFILETFRHSSFVP-FTIPHSTTRDTSLK 397

Query: 423 GQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERY 457
           G  IP G  + +    ++HD + W +P  F PER+
Sbjct: 398 GFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERF 432


>gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11
           [Homo sapiens]
          Length = 519

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 38/120 (31%), Positives = 66/120 (55%), Gaps = 2/120 (1%)

Query: 339 FLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVI 398
           F+  G++   + +S+  Y LAT+P  QE+   E+        +  +  L++ +PY  M I
Sbjct: 318 FMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQ-MPYTTMCI 376

Query: 399 AETLRMYPPAFRFTREAAQDCEVL-GQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERY 457
            E LR+YPP     RE +       G+ +P G ++ +++  LHH+P+ WP+PE F+P R+
Sbjct: 377 KEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRF 436


>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 44/136 (32%), Positives = 80/136 (58%), Gaps = 4/136 (2%)

Query: 325 RPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKH-MAP 382
           + L+ ++I  +A  F+  G++   + LS+  Y LA +P+ QE+  +EV ++ K++  +  
Sbjct: 311 KELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEI 370

Query: 383 EFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL-GQRIPAGAVLEMAVGALHH 441
           E+  L + LP+L M I E+LR++PP    +R   QD  +  G+ IP G V  + +  +H+
Sbjct: 371 EWDDLAQ-LPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHY 429

Query: 442 DPEHWPSPETFNPERY 457
           +P  WP PE ++P R+
Sbjct: 430 NPTVWPDPEVYDPFRF 445


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.139    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,786,392
Number of Sequences: 37866
Number of extensions: 796983
Number of successful extensions: 2551
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 69
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 2383
Number of HSP's gapped (non-prelim): 100
length of query: 460
length of database: 18,247,518
effective HSP length: 106
effective length of query: 354
effective length of database: 14,233,722
effective search space: 5038737588
effective search space used: 5038737588
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.