Search of human proteins with 195972898

Search of human proteins with 195972898

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I
[Homo sapiens]
         (534 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H...  1080   0.0  
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H...  1080   0.0  
gi|195972900 thromboxane A synthase 1, platelet isoform TXS-II [...   925   0.0  
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   320   2e-87
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   314   1e-85
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...   310   3e-84
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   304   1e-82
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...   300   3e-81
gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide ...   239   5e-63
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   143   3e-34
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ...   132   8e-31
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8...   121   2e-27
gi|5729796 cytochrome P450, family 46 [Homo sapiens]                  119   7e-27
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                  119   9e-27
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...   116   6e-26
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide...   115   1e-25
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   114   2e-25
gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide...   114   2e-25
gi|30023836 cytochrome P450 4Z1 [Homo sapiens]                        112   8e-25
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   112   1e-24
gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide...   111   1e-24
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ...   110   2e-24
gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide...   110   2e-24
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide...   110   4e-24
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   105   8e-23
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11...   105   8e-23
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11...   105   8e-23
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ...   105   1e-22
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ...   105   1e-22
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...   103   3e-22

>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score = 1080 bits (2793), Expect = 0.0
 Identities = 534/534 (100%), Positives = 534/534 (100%)

Query: 1   MMEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFF 60
           MMEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFF
Sbjct: 1   MMEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFF 60

Query: 61  RQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKS 120
           RQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKS
Sbjct: 61  RQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKS 120

Query: 121 VADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ 180
           VADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ
Sbjct: 121 VADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ 180

Query: 181 RCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPL 240
           RCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPL
Sbjct: 181 RCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPL 240

Query: 241 ARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDI 300
           ARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDI
Sbjct: 241 ARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDI 300

Query: 301 VRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLAT 360
           VRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLAT
Sbjct: 301 VRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLAT 360

Query: 361 NPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCE 420
           NPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCE
Sbjct: 361 NPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCE 420

Query: 421 VLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSC 480
           VLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSC
Sbjct: 421 VLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSC 480

Query: 481 LGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR 534
           LGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
Sbjct: 481 LGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR 534


>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score = 1080 bits (2793), Expect = 0.0
 Identities = 534/534 (100%), Positives = 534/534 (100%)

Query: 1   MMEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFF 60
           MMEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFF
Sbjct: 1   MMEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFF 60

Query: 61  RQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKS 120
           RQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKS
Sbjct: 61  RQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKS 120

Query: 121 VADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ 180
           VADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ
Sbjct: 121 VADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ 180

Query: 181 RCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPL 240
           RCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPL
Sbjct: 181 RCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPL 240

Query: 241 ARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDI 300
           ARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDI
Sbjct: 241 ARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDI 300

Query: 301 VRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLAT 360
           VRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLAT
Sbjct: 301 VRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLAT 360

Query: 361 NPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCE 420
           NPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCE
Sbjct: 361 NPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCE 420

Query: 421 VLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSC 480
           VLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSC
Sbjct: 421 VLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSC 480

Query: 481 LGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR 534
           LGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
Sbjct: 481 LGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR 534


>gi|195972900 thromboxane A synthase 1, platelet isoform TXS-II
           [Homo sapiens]
          Length = 460

 Score =  925 bits (2390), Expect = 0.0
 Identities = 456/457 (99%), Positives = 457/457 (100%)

Query: 1   MMEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFF 60
           MMEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFF
Sbjct: 1   MMEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFF 60

Query: 61  RQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKS 120
           RQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKS
Sbjct: 61  RQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKS 120

Query: 121 VADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ 180
           VADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ
Sbjct: 121 VADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ 180

Query: 181 RCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPL 240
           RCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPL
Sbjct: 181 RCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPL 240

Query: 241 ARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDI 300
           ARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDI
Sbjct: 241 ARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDI 300

Query: 301 VRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLAT 360
           VRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLAT
Sbjct: 301 VRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLAT 360

Query: 361 NPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCE 420
           NPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCE
Sbjct: 361 NPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCE 420

Query: 421 VLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERF 457
           VLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPER+
Sbjct: 421 VLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERY 457


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  320 bits (820), Expect = 2e-87
 Identities = 189/526 (35%), Positives = 289/526 (54%), Gaps = 45/526 (8%)

Query: 16  MVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLY 75
           M T  L    L LL  Y T +    +KLG+  P P PF+GN+  + +GF    ME  K Y
Sbjct: 9   METWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKY 68

Query: 76  GPLCGYYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASG-LEFKSVADSVLFLRDKRW 133
           G + G+Y G++  + I++PDMIK VLV E +S FTNR   G + F   A S+    D+ W
Sbjct: 69  GKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIA--EDEEW 126

Query: 134 EEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVAS 193
           + +R  L   F+  KL EMVP+I+Q  D+L+ +L+R AE+G    ++  +  Y+ DV+ S
Sbjct: 127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186

Query: 194 VAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARIL-----PNKN 248
            +FG  +DS   P+DPFV++ K+   F    P  + +  FP  ++P+  +L     P   
Sbjct: 187 TSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFP-FLIPILEVLNICVFPR-- 243

Query: 249 RDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSST 308
             E+  F  K ++ +   R +   ++ R DFLQ+++D+++S                   
Sbjct: 244 --EVTNFLRKSVKRMKESRLEDT-QKHRVDFLQLMIDSQNSKE----------------- 283

Query: 309 GCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKL 368
                 +  H      + L+  E+V Q+ IF+ AGYE  ++ LSF  Y LAT+PD Q+KL
Sbjct: 284 ------TESH------KALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKL 331

Query: 369 LREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPA 428
             E+D        P + ++ + + YLDMV+ ETLR++P A R  R   +D E+ G  IP 
Sbjct: 332 QEEIDAVLPNKAPPTYDTVLQ-MEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPK 390

Query: 429 GAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLL 488
           G V+ +   ALH DP++W  PE F PERF+ + +    P+ Y PFG+GPR+C+G+R  L+
Sbjct: 391 GVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALM 450

Query: 489 EVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR 534
            +KL L+ VL  F F+ C ETQ+PL+L     L P+  V +K+ SR
Sbjct: 451 NMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  314 bits (804), Expect = 1e-85
 Identities = 181/522 (34%), Positives = 288/522 (55%), Gaps = 42/522 (8%)

Query: 18  TVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGP 77
           T  L    L LL  Y T      ++LG+  P P P +GN+  +RQG W+   E  K YG 
Sbjct: 11  TWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGK 70

Query: 78  LCGYYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEV 136
           + G Y G+   + I++PD+I+ VLV E +S FTNR + G     +  ++    D+ W+ +
Sbjct: 71  MWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLG-PVGFMKSAISLAEDEEWKRI 129

Query: 137 RGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAF 196
           R  L   F+  KL EM P+I+Q  D+L+ +L+R AE G    ++  +  Y+ DV+   +F
Sbjct: 130 RSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSF 189

Query: 197 GTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNK--NRDELNG 254
           G  +DS   P+DPFV+  K+F +F    P+ + ++ FP  + P+   L      +D +N 
Sbjct: 190 GVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFP-FLTPVFEALNVSLFPKDTIN- 247

Query: 255 FFNKLIRNV--IALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKP 312
           F +K +  +    L D+Q   + R DFLQ+++D+++S                       
Sbjct: 248 FLSKSVNRMKKSRLNDKQ---KHRLDFLQLMIDSQNSKE--------------------- 283

Query: 313 NPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV 372
             +  H      + L+  E+  Q+ IF+ AGYE  ++ LSF  Y LAT+PD Q+KL +E+
Sbjct: 284 --TESH------KALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEI 335

Query: 373 DVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVL 432
           D        P + ++ + + YLDMV+ ETLR++P A R  R   +D E+ G  IP G+++
Sbjct: 336 DAVLPNKAPPTYDAVVQ-MEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMV 394

Query: 433 EMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKL 492
            +   ALHHDP++W  PE F PERF+ + +    P+ Y PFG GPR+C+G+R  L+ +KL
Sbjct: 395 VIPTYALHHDPKYWTEPEEFRPERFSKK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKL 453

Query: 493 TLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR 534
            L+ VL  F F+ C ETQ+PL+L+++  L P+  + +K+ SR
Sbjct: 454 ALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 495


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score =  310 bits (793), Expect = 3e-84
 Identities = 179/515 (34%), Positives = 284/515 (55%), Gaps = 34/515 (6%)

Query: 21  LSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCG 80
           L+V+L+ LL  Y T      +KLG+  P P PF+GN   FR+G+W   ME  K Y  + G
Sbjct: 15  LAVSLI-LLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDMECYKKYRKVWG 73

Query: 81  YYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGA 139
            Y  ++  + I++PDMIK VLV E +S FTNR   G     + +++    D+ W+ +R  
Sbjct: 74  IYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFG-PVGFMKNAISIAEDEEWKRIRSL 132

Query: 140 LMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTP 199
           L   F+  KL EMVP+I+Q  D+L+ +L+R AE+G    ++  +  Y+ DV+ S +FG  
Sbjct: 133 LSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVS 192

Query: 200 VDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKL 259
           +DS   P+DPFV++ K+   F    P ++ +  FP +   L  +       ++  F  K 
Sbjct: 193 IDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKS 252

Query: 260 IRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQ 319
           ++ +   R ++  ++ R DFLQ+++D+++S                             +
Sbjct: 253 VKQIKEGRLKET-QKHRVDFLQLMIDSQNS-----------------------------K 282

Query: 320 PSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKH 379
            S   + L+  E++ Q+ IF+ AGYE  ++ LSF  Y LAT+PD Q+K+ +E+D      
Sbjct: 283 DSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNK 342

Query: 380 MAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGAL 439
             P + ++ + L YLDMV+ ETLR++P A R  R   +D E+ G  IP G V+ +    L
Sbjct: 343 APPTYDTVLQ-LEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVL 401

Query: 440 HHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLH 499
           HHDP++W  PE F PERF+ + +    P+ Y PFG+GPR+C+G+R  L+ +KL L+ VL 
Sbjct: 402 HHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQ 461

Query: 500 KFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR 534
            F F+ C ETQ+PL+L     L  +  + +K  SR
Sbjct: 462 NFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESR 496


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  304 bits (779), Expect = 1e-82
 Identities = 176/522 (33%), Positives = 277/522 (53%), Gaps = 37/522 (7%)

Query: 13  NGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELR 72
           N  M T  L    L LL  Y T +    +KLG+  P P PF+G + F+ +G W    E  
Sbjct: 6   NFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECN 65

Query: 73  KLYGPLCGYYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASGLEFKSVADSVLFLRDK 131
           + YG + G Y G++  +VI +PDMIK VLV E +S FTN+M  G     +  ++ F  D+
Sbjct: 66  EKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLG-PMGFLKSALSFAEDE 124

Query: 132 RWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVV 191
            W+ +R  L  AF+  K  EMVP+ISQ  D+L+  L++ AE+  + +++  +  YT DV+
Sbjct: 125 EWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184

Query: 192 ASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDE 251
               FG  +DS   P+DPF+K+ K+  +     P L+L+  FP +      +       +
Sbjct: 185 TGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKD 244

Query: 252 LNGFFNKLIRNV--IALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTG 309
           +  F    I  +    L+D+Q   + R DF Q ++D+++S                    
Sbjct: 245 VTHFLKNSIERMKESRLKDKQ---KHRVDFFQQMIDSQNSKE------------------ 283

Query: 310 CKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLL 369
                ++ H      + L+  E+V Q+ I + A Y+  + TL F  Y LAT+PD Q+KL 
Sbjct: 284 -----TKSH------KALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQ 332

Query: 370 REVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAG 429
            E+D          + +L + + YLDMV+ ETLR++P   R TR   +D E+ G  IP G
Sbjct: 333 EEIDAVLPNKAPVTYDALVQ-MEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKG 391

Query: 430 AVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLE 489
             + + + ALHHDP++W  PE F PERF+ + +     + Y+PFGAGPR+C+G+R  L  
Sbjct: 392 LAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTN 451

Query: 490 VKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKI 531
           +KL ++  L  F F+ C ETQ+PL+L++   L P+  + +K+
Sbjct: 452 IKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKV 493


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score =  300 bits (767), Expect = 3e-81
 Identities = 176/523 (33%), Positives = 277/523 (52%), Gaps = 38/523 (7%)

Query: 13  NGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELR 72
           N  M T  L    L LL  Y T +    +KLG+  P P PF+G + F+ +G W    E  
Sbjct: 6   NFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECN 65

Query: 73  KLYGPLCGYYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASGLEFKSVADSVLFLRDK 131
           + YG + G Y G++  +VI +PDMIK VLV E +S FTN+M  G     +  ++ F  D+
Sbjct: 66  EKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLG-PMGFLKSALSFAEDE 124

Query: 132 RWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVV 191
            W+ +R  L  AF+  K  EMVP+ISQ  D+L+  L++ AE+  + +++  +  YT DV+
Sbjct: 125 EWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184

Query: 192 ASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDE 251
               FG  +DS   P+DPF+K+ K+  +     P L+L+  FP +      +       +
Sbjct: 185 TGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKD 244

Query: 252 LNGFFNKLIRNV--IALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTG 309
           +  F    I  +    L+D+Q   + R DF Q ++D+++S                    
Sbjct: 245 VTHFLKNSIERMKESRLKDKQ---KHRVDFFQQMIDSQNSKE------------------ 283

Query: 310 CKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLL 369
                ++ H      + L+  E+V Q+ I + A Y+  + TL F  Y LAT+PD Q+KL 
Sbjct: 284 -----TKSH------KALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQ 332

Query: 370 REVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAG 429
            E+D          + +L + + YLDMV+ ETLR++P   R TR   +D E+ G  IP G
Sbjct: 333 EEIDAVLPNKAPVTYDALVQ-MEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKG 391

Query: 430 AVLEMAVGALHHDPEHWPSPETFNPE-RFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLL 488
             + + + ALHHDP++W  PE F PE RF+ + +     + Y+PFGAGPR+C+G+R  L 
Sbjct: 392 LAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALT 451

Query: 489 EVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKI 531
            +KL ++  L  F F+ C ETQ+PL+L++   L P+  + +K+
Sbjct: 452 NIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKV 494


>gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 3 [Homo sapiens]
          Length = 420

 Score =  239 bits (610), Expect = 5e-63
 Identities = 148/447 (33%), Positives = 229/447 (51%), Gaps = 37/447 (8%)

Query: 13  NGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELR 72
           N  M T  L    L LL  Y T +    +KLG+  P P PF+G + F+ +G W    E  
Sbjct: 6   NFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECN 65

Query: 73  KLYGPLCGYYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASGLEFKSVADSVLFLRDK 131
           + YG + G Y G++  +VI +PDMIK VLV E +S FTN+M  G     +  ++ F  D+
Sbjct: 66  EKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLG-PMGFLKSALSFAEDE 124

Query: 132 RWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVV 191
            W+ +R  L  AF+  K  EMVP+ISQ  D+L+  L++ AE+  + +++  +  YT DV+
Sbjct: 125 EWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184

Query: 192 ASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDE 251
               FG  +DS   P+DPF+K+ K+  +     P L+L+  FP +      +       +
Sbjct: 185 TGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKD 244

Query: 252 LNGFFNKLIRNV--IALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTG 309
           +  F    I  +    L+D+Q   + R DF Q ++D+++S                    
Sbjct: 245 VTHFLKNSIERMKESRLKDKQ---KHRVDFFQQMIDSQNSKE------------------ 283

Query: 310 CKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLL 369
                ++ H      + L+  E+V Q+ I + A Y+  + TL F  Y LAT+PD Q+KL 
Sbjct: 284 -----TKSH------KALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQ 332

Query: 370 REVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAG 429
            E+D          + +L + + YLDMV+ ETLR++P   R TR   +D E+ G  IP G
Sbjct: 333 EEIDAVLPNKAPVTYDALVQ-MEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKG 391

Query: 430 AVLEMAVGALHHDPEHWPSPETFNPER 456
             + + + ALHHDP++W  PE F PER
Sbjct: 392 LAVMVPIYALHHDPKYWTEPEKFCPER 418


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  143 bits (361), Expect = 3e-34
 Identities = 131/544 (24%), Positives = 239/544 (43%), Gaps = 53/544 (9%)

Query: 9   KLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPS-----PFIGNLTFFR-- 61
           KL + G    ++L+ A L L      ++++R  K     P P+     P +G+    +  
Sbjct: 12  KLLLWGAASALSLAGASLVLSLLQRVASYAR--KWQQMRPIPTVARAYPLVGHALLMKPD 69

Query: 62  -QGFWESQMELRKLYG--PLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEF 118
            + F++  +E  + Y   PL   ++G    + +   + ++ +L  +     + M   LE 
Sbjct: 70  GREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLE- 128

Query: 119 KSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFD 178
             +   +L     +W   R  L   F    L + + ++++  ++L+  L+++    +AF+
Sbjct: 129 PWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQ-EAFN 187

Query: 179 IQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMV 238
                     D++   A G  + +    +  +V+   R  E    R      +  P + +
Sbjct: 188 CFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRR------IKMPWLWL 241

Query: 239 PLARIL------PNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASP 292
            L  ++        K+   L+ F N +I       +  A E+ R D        R SA  
Sbjct: 242 DLWYLMFKEGWEHKKSLQILHTFTNSVIAE--RANEMNANEDCRGD-------GRGSAPS 292

Query: 293 MGVQD--FDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNT 350
              +    D++  V    G +               L+ ++I  +   F+  G++     
Sbjct: 293 KNKRRAFLDLLLSVTDDEGNR---------------LSHEDIREEVDTFMFEGHDTTAAA 337

Query: 351 LSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFR 410
           ++++ YLL +NP+ Q+K+  E+D    K   P      + L YL+ VI ETLR++P    
Sbjct: 338 INWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPL 397

Query: 411 FTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTY 470
           F R  ++DCEV G R+  G    +   ALH DP ++P+PE F PERF  E  Q   P+ Y
Sbjct: 398 FARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAY 457

Query: 471 LPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIK 530
           +PF AGPR+C+G +  ++E K  L  +L  F  ++  + +  L LE +  L P NG++IK
Sbjct: 458 VPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIES-NQKREELGLEGQLILRPSNGIWIK 516

Query: 531 IVSR 534
           +  R
Sbjct: 517 LKRR 520


>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
           [Homo sapiens]
          Length = 509

 Score =  132 bits (332), Expect = 8e-31
 Identities = 126/531 (23%), Positives = 227/531 (42%), Gaps = 69/531 (12%)

Query: 21  LSVALLALLKWYSTSAFSRLEKLGLRHPKPSP----FIGNLTFFRQGFWESQMELRKLYG 76
           L++ LL  +K Y      R   L    P P+P    F+G+  F +    E   E+ + Y 
Sbjct: 22  LALGLLQAIKLY----LRRQRLLRDLRPFPAPPTHWFLGHQKFIQDDNMEKLEEIIEKYP 77

Query: 77  PLCGYYLGR-RMFIVISEPDMIKQVL--VENFSNFTNRMASGLEFKSVADSVLFLRDKRW 133
               +++G  + F  I +PD  K +L   +  S +  + +  L  K +A     L   +W
Sbjct: 78  RAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAA----LDGPKW 133

Query: 134 EEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGD-AFDIQRCYCNYTTDVVA 192
            + R  L   F    L   + +++ +  ++L   ++   + D + ++     + + D++ 
Sbjct: 134 FQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIM 193

Query: 193 SVAFGTPVD-SWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNR-D 250
             AF    +    +  DP+ K      +    R  L  LL    I+  L+   P   R  
Sbjct: 194 KCAFSKETNCQTNSTHDPYAKAIFELSKIIFHR--LYSLLYHSDIIFKLS---PQGYRFQ 248

Query: 251 ELNGFFNKLIRNVI---------ALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIV 301
           +L+   N+    +I          ++     + + +DFL +VL A+   S     D D+ 
Sbjct: 249 KLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDE-SGSSFSDIDVH 307

Query: 302 RDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATN 361
            +V +                                FL+AG++ +  ++S+  Y LA N
Sbjct: 308 SEVST--------------------------------FLLAGHDTLAASISWILYCLALN 335

Query: 362 PDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEV 421
           P+ QE+   EV        +  +  L E + Y  M I ET R+ P     +R+ ++    
Sbjct: 336 PEHQERCREEVRGILGDGSSITWDQLGE-MSYTTMCIKETCRLIPAVPSISRDLSKPLTF 394

Query: 422 L-GQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSC 480
             G  +PAG  + +++  LHH+P  W +P+ F+P RF+ E   Q  P+ YLPF AG R+C
Sbjct: 395 PDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNC 454

Query: 481 LGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKI 531
           +G    ++E+K+T+  +L    F+  P+   PL   +   L PKNG+Y+ +
Sbjct: 455 IGQEFAMIELKVTIALIL--LHFRVTPDPTRPLTFPNHFILKPKNGMYLHL 503


>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
           [Homo sapiens]
          Length = 520

 Score =  121 bits (303), Expect = 2e-27
 Identities = 107/426 (25%), Positives = 185/426 (43%), Gaps = 56/426 (13%)

Query: 121 VADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDA-FDI 179
           + D +L     +W   R  L  AF    L   + + S++ +++ A  +R A  G    D+
Sbjct: 132 LGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDV 191

Query: 180 QRCYCNYTTDVVASVAFGTPVDSWQAPEDPF----------VKHCKRFFEFCIPRPILVL 229
                  T D +    F    +  + P +            VK   +FF +         
Sbjct: 192 FEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFFRY--------- 242

Query: 230 LLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHS 289
              F   + P  R             F++  R V    D    E RR    Q V D   +
Sbjct: 243 -KDFLYFLTPCGRR------------FHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQA 289

Query: 290 ASPMGVQDF-DIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIIT 348
            +     DF D++       G               + L+ ++I  +A  F+  G++   
Sbjct: 290 KAKSKTLDFIDVLLLSEDKNG---------------KELSDEDIRAEADTFMFGGHDTTA 334

Query: 349 NTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAP-EFCSLEEGLPYLDMVIAETLRMYP 406
           + LS+  Y LA +P+ QE+  +EV ++ K++     E+  L + LP+L M + E+LR++P
Sbjct: 335 SGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQ-LPFLTMCLKESLRLHP 393

Query: 407 PAFRFTREAAQDCEVLGQR-IPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQH 465
           P   F R   QD  +   R IP G V  + + A+HH+P  WP PE ++P RF  E  Q+ 
Sbjct: 394 PIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKR 453

Query: 466 RPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKN 525
            P  ++PF AGPR+C+G +  + E+K+ L   L   RF+  P+ + P +   +  L  ++
Sbjct: 454 SPMAFIPFSAGPRNCIGQKFAMAEMKVVL--ALTLLRFRILPDHREP-RRTPEIVLRAED 510

Query: 526 GVYIKI 531
           G+++++
Sbjct: 511 GLWLRV 516


>gi|5729796 cytochrome P450, family 46 [Homo sapiens]
          Length = 500

 Score =  119 bits (298), Expect = 7e-27
 Identities = 116/492 (23%), Positives = 200/492 (40%), Gaps = 82/492 (16%)

Query: 48  PKPSPFIGNLTFFRQGFWESQ-----------MELRKLYGPLCGYYLGRRMFIVISEPDM 96
           P+PS  +G+L  F    W+             ++  K YGP+    +  +  ++++ P+ 
Sbjct: 37  PRPSFLLGHLPCF----WKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPES 92

Query: 97  IKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD-------KRWEEVRGALMSAFSPEKL 149
           +K+ L+    N  ++M   L+  +V    LF +        +RW + R  +  AFS   L
Sbjct: 93  VKKFLMSTKYNKDSKMYRALQ--TVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSL 150

Query: 150 NEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDP 209
             ++   ++  + L+  L+  A+      +Q        D++A  AFG         + P
Sbjct: 151 VSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKP 210

Query: 210 FVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRD-----ELNGFFNKLIRNVI 264
                       + + + ++L    +    LA+ LP K +      E   F  ++ R+ +
Sbjct: 211 ------------LSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWV 258

Query: 265 ALRDQ--QAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSP 322
             R +  +  EE   D L  +L A       G QD + + D F +               
Sbjct: 259 QRRREALKRGEEVPADILTQILKAEE-----GAQDDEGLLDNFVT--------------- 298

Query: 323 MARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAP 382
                           F IAG+E   N L+F    L+  P+   +L  EVD         
Sbjct: 299 ----------------FFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYL 342

Query: 383 EFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHD 442
           +F  L   L YL  V+ E+LR+YPPA+   R   ++  + G R+P    L  +   +   
Sbjct: 343 DFEDLGR-LQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRM 401

Query: 443 PEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR 502
             ++  P TFNP+RF   A +    FTY PF  G RSC+G +   +EVK+ +  +L +  
Sbjct: 402 DTYFEDPLTFNPDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE 459

Query: 503 FQACPETQVPLQ 514
           F+  P  +  LQ
Sbjct: 460 FRLVPGQRFGLQ 471


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score =  119 bits (297), Expect = 9e-27
 Identities = 135/521 (25%), Positives = 218/521 (41%), Gaps = 78/521 (14%)

Query: 19  VALSVALLALLKWYSTSAFSRLEKLGLRHPKPS---PFIGNLTFF-RQGFWESQM-ELRK 73
           VAL +  LA L W       +    G ++PK     P +G+L F  R G   +   +L+K
Sbjct: 5   VALLLLTLAYLFW------PKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQK 58

Query: 74  LYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNR-MASGLEFKSVADSVLFLRDK- 131
            YGP+    +G +  +++    + K+VL++   +F+ R   + L+  S     +   D  
Sbjct: 59  KYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSG 118

Query: 132 -RWEEVRGALMSAFS-----PEKLNEMV-PLISQACDLLLAHLKRYAESGDAFDIQRCYC 184
             W+  R   M+ F+      +KL +++   IS  CD+L  H      +G + DI     
Sbjct: 119 AHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATH------NGQSIDISFPVF 172

Query: 185 NYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSI--MVPLAR 242
              T+V++ + F T   +     DP +   + + E  I        LS  S+  +VP  +
Sbjct: 173 VAVTNVISLICFNTSYKNG----DPELNVIQNYNEGIIDN------LSKDSLVDLVPWLK 222

Query: 243 ILPNKNRDEL-------NGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGV 295
           I PNK  ++L       N   NK++ N          E+ R D +  +LD    A     
Sbjct: 223 IFPNKTLEKLKSHVKIRNDLLNKILENY--------KEKFRSDSITNMLDTLMQAK---- 270

Query: 296 QDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLT-VDEIVGQAFIFLIAGYEIITNTLSFA 354
                     +S      P +  +       LT + +I G       AG E  T+ + + 
Sbjct: 271 ---------MNSDNGNAGPDQDSELLSDNHILTTIGDIFG-------AGVETTTSVVKWT 314

Query: 355 TYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTRE 414
              L  NP  ++KL  E+D        P   S    L  L+  I E LR+ P A      
Sbjct: 315 LAFLLHNPQVKKKLYEEIDQNVGFSRTPTI-SDRNRLLLLEATIREVLRLRPVAPMLIPH 373

Query: 415 AAQDCEVLGQ-RIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQ--HRPFTYL 471
            A     +G+  +  G  + + + ALHH+ + W  P+ F PERF   A  Q      +YL
Sbjct: 374 KANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYL 433

Query: 472 PFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVP 512
           PFGAGPRSC+G  L   E+ L +  +L +F  +   + Q+P
Sbjct: 434 PFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLP 474


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score =  116 bits (290), Expect = 6e-26
 Identities = 130/503 (25%), Positives = 218/503 (43%), Gaps = 57/503 (11%)

Query: 15  PMVTVALSVALLALLK-WYSTSAFSRLEKLGLRHPKPSPFIGN-LTFFRQGFWESQMELR 72
           P V + L ++ L LL  W  +S   +L       P P P IGN L    +   +S   L 
Sbjct: 3   PFVVLVLCLSCLLLLSIWRQSSGRGKLPP----GPTPLPVIGNILQIDIKDVSKSLTNLS 58

Query: 73  KLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGL-EFKSVADSVLFLRDK 131
           K+YGP+   Y G    +V+   +++K+ L++    F+ R    L E  +    ++F   K
Sbjct: 59  KIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGK 118

Query: 132 RWEEVRG-ALMSA--FSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCY-CNYT 187
           RW+E+R  +LM+   F   K +    +  +A  L+    K  A   D   I  C  CN  
Sbjct: 119 RWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCN-- 176

Query: 188 TDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFC--IPRPILVLLLSFPSIMVPLARILP 245
             V+ S+ F    D     +  F+   ++  E    +  P + +  +FP+I+        
Sbjct: 177 --VICSIIFQKRFDY---KDQQFLNLMEKLNENIRIVSTPWIQICNNFPTII-------- 223

Query: 246 NKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVF 305
               D   G  NKL++N+  +           D L+ V + + S       D +  RD  
Sbjct: 224 ----DYFPGTHNKLLKNLAFMES---------DILEKVKEHQES------MDINNPRDFI 264

Query: 306 SSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQ 365
                K    +Q+Q S      T++ +V  A   L AG E  + TL +A  LL  +P+  
Sbjct: 265 DCFLIKMEKEKQNQQSEF----TIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVT 320

Query: 366 EKLLREVDVFKEKHMAPEFCSLEEG-LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ 424
            K+  E++    ++ +P  C  + G +PY D V+ E  R Y      +   A  C+V  +
Sbjct: 321 AKVQEEIERVIGRNRSP--CMQDRGHMPYTDAVVHEVQR-YIDLIPTSLPHAVTCDVKFR 377

Query: 425 R--IPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLG 482
              IP G  +  ++ ++ HD + +P+PE F+P  F  E     +   ++PF AG R C+G
Sbjct: 378 NYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVG 437

Query: 483 VRLGLLEVKLTLLHVLHKFRFQA 505
             L  +E+ L L  +L  F  ++
Sbjct: 438 EGLARMELFLFLTFILQNFNLKS 460


>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
           [Homo sapiens]
          Length = 520

 Score =  115 bits (287), Expect = 1e-25
 Identities = 125/504 (24%), Positives = 219/504 (43%), Gaps = 62/504 (12%)

Query: 48  PKPSPFIGNLTFFR---QGFWESQMELRKLYGPLCGYYLGRRMFIV-ISEPDMIKQVLVE 103
           PK + F+G+L       +G   +Q  L   +G +C +++G    IV I  P  IK VL  
Sbjct: 55  PKRNWFLGHLGLIHSSEEGLLYTQ-SLACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFA 113

Query: 104 NFSNFTNRMASGLEFKS-VADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDL 162
             +            K  + D +L    ++W   R  L  AF    L   + + +++ ++
Sbjct: 114 PAAIVPKDKVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNI 173

Query: 163 LLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCI 222
           + A  +  A  G A            D+   ++  T +DS Q     F  HC+       
Sbjct: 174 MHAKWQLLASEGSA----------RLDMFEHISLMT-LDSLQKCVFSFDSHCQEK----- 217

Query: 223 PRPILVLLLSFPSIMVP-----------LARILPNKNRDELNGFFNKLIRNVIALRDQQA 271
           P   +  +L   +++             L  + P+  R      F +  R V    D   
Sbjct: 218 PSEYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQR------FRRACRLVHDFTDAVI 271

Query: 272 AEERRRDFLQMVLDARHSASPMGVQDF-DIVRDVFSSTGCKPNPSRQHQPSPMARPLTVD 330
            E RR    Q V D   + +     DF D++       G K               L+ +
Sbjct: 272 QERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKK---------------LSDE 316

Query: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAP-EFCSLE 388
           +I  +A  F+  G++   + LS+  Y LA +P+ QE+  +EV ++ K++     E+  L 
Sbjct: 317 DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLA 376

Query: 389 EGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL-GQRIPAGAVLEMAVGALHHDPEHWP 447
           + LP+L M I E+LR++PP    +R   QD  +  G+ IP G +  ++V   HH+P  WP
Sbjct: 377 Q-LPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWP 435

Query: 448 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACP 507
            PE ++P RF  +  ++  P  ++PF AGPR+C+G    + E+K+ L   L   RF+  P
Sbjct: 436 DPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVL--GLTLLRFRVLP 493

Query: 508 ETQVPLQLESKSALGPKNGVYIKI 531
           +   P + + +  L  + G+++++
Sbjct: 494 DHTEP-RRKPELVLRAEGGLWLRV 516


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  114 bits (286), Expect = 2e-25
 Identities = 119/540 (22%), Positives = 218/540 (40%), Gaps = 72/540 (13%)

Query: 5   LGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRH-PKPSPFIGNL------ 57
           LG L+L+ +G  +   L   L+ALL W   S   R    G+   P P P +GN       
Sbjct: 25  LGLLRLDPSGGAL---LLCGLVALLGW---SWLRRRRARGIPPGPTPWPLVGNFGHVLLP 78

Query: 58  TFFRQGFWESQM------------------ELRKLYGPLCGYYLGRRMFIVISEPDMIKQ 99
            F R+  W S                     L ++YG +  +++G  + +V+S+   +++
Sbjct: 79  PFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVRE 138

Query: 100 VLVENFSNFTNRMASGL-EFKSVADSVLFLR-DKRWEEVRG---ALMSAFSPEKLNEMVP 154
            LV+    F++R    L    +    V+F      W + R    + +  F   KL+ + P
Sbjct: 139 ALVQQAEVFSDRPRVPLISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLS-LEP 197

Query: 155 LISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHC 214
            I +    + A ++++ E  D F       N  ++++ S+ FG   D   +     +   
Sbjct: 198 KIIEEFKYVKAEMQKHGE--DPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFM 255

Query: 215 KRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEE 274
            R  E C+   +L++ +      +P     P K   ++       ++ +I    +    E
Sbjct: 256 SRGLEICLNSQVLLVNICPWLYYLPFG---PFKELRQIEKDITSFLKKIIKDHQESLDRE 312

Query: 275 RRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVG 334
             +DF+ M L                               R++  +       +  I+G
Sbjct: 313 NPQDFIDMYL-------------------------LHMEEERKNNSNSSFDEEYLFYIIG 347

Query: 335 QAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYL 394
             FI   AG +  TN+L +    ++ NPD QEK+  E++     + AP      + +PY 
Sbjct: 348 DLFI---AGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQ-MPYT 403

Query: 395 DMVIAETLRMYPPA-FRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFN 453
           +  I E  R+            +++  + G  IP G ++   + ++H DP  W  PE F 
Sbjct: 404 EATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFY 463

Query: 454 PERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPL 513
           P RF  +  Q  +  T++PFG G R C+G +L  +E+ L  + ++  F F    +++ PL
Sbjct: 464 PNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPL 523


>gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22
           [Homo sapiens]
          Length = 531

 Score =  114 bits (285), Expect = 2e-25
 Identities = 109/448 (24%), Positives = 201/448 (44%), Gaps = 35/448 (7%)

Query: 89  IVISEPDMIKQVLVENFSNFT-NRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPE 147
           +V+  PD IK +L  + +    + +  G     + D +L  +  +W   R  L  AF  +
Sbjct: 107 LVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFD 166

Query: 148 KLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPE 207
            L   + + +Q+ D++ A  +  AE G A  +         D+   ++  T +DS Q   
Sbjct: 167 ILKPYMKIFNQSADIMHAKWRHLAE-GSAVSL---------DMFEHISLMT-LDSLQKCV 215

Query: 208 DPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALR 267
             +  +C+      I   I +  LS       L   L        +G   +   +++   
Sbjct: 216 FSYNSNCQEKMSDYISAIIELSALSVRR-QYRLHHYLDFIYYRSADGRRFRQACDMVHHF 274

Query: 268 DQQAAEERRRDFLQMVLDARHSASPMGVQDF-DIVRDVFSSTGCKPNPSRQHQPSPMARP 326
             +  +ERRR   Q   +A   A      DF D++       G               + 
Sbjct: 275 TTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDG---------------KE 319

Query: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAP-EF 384
           L+ ++I  +A  F+  G++  ++ +S+  + LA  P+ QEK   E+ +V K + +   E+
Sbjct: 320 LSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEW 379

Query: 385 CSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL-GQRIPAGAVLEMAVGALHHDP 443
             L + LP+  M I E+LR YPP    +R+  +D ++  G+ IP G +  +++   HH+P
Sbjct: 380 DDLTQ-LPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNP 438

Query: 444 EHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRF 503
             WP  + +NP RF  +  QQ  P  Y+PF AGPR+C+G    + E+++ +   L +FR 
Sbjct: 439 TVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRL 498

Query: 504 QACPETQVPLQLESKSALGPKNGVYIKI 531
                 +V  + + +  L  +NG+++K+
Sbjct: 499 SVDRTRKV--RRKPELILRTENGLWLKV 524


>gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
          Length = 505

 Score =  112 bits (280), Expect = 8e-25
 Identities = 113/532 (21%), Positives = 223/532 (41%), Gaps = 67/532 (12%)

Query: 16  MVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSP----FIGNLTFFRQGFWESQMEL 71
           ++ + +S+ L  +++ Y      R   +   H  P+P    F G+  F+    +E   +L
Sbjct: 17  LILLCMSLLLFQVIRLYQR----RRWMIRALHLFPAPPAHWFYGHKEFYPVKEFEVYHKL 72

Query: 72  RKLYGPLCGYYLGR-RMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD 130
            + Y      ++G   MF  + +PD  K +L        + ++  +    V   ++ L  
Sbjct: 73  MEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPK--SAVSHKILESWVGRGLVTLDG 130

Query: 131 KRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDV 190
            +W++ R  +   F+   L   + ++S++  ++L   + +       ++ +     T D 
Sbjct: 131 SKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDS 190

Query: 191 VASVAFG--------TPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLAR 242
           +   AF         + +DS+        K   +     +    LV   S    +     
Sbjct: 191 IMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIF---- 246

Query: 243 ILPNKNRDELNGFFNKLIRN-VIALRD---QQAAEERRRDFLQMVLDARHSASPMGVQDF 298
              +K   EL+ F  K+I++   +L+D   Q   ++RR DFL ++L A+           
Sbjct: 247 ---SKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAK----------- 292

Query: 299 DIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLL 358
                                 S   +  +  ++  +   F+ AG++  ++ +S+  Y L
Sbjct: 293 ----------------------SENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCL 330

Query: 359 ATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQD 418
           A  P+ Q++   E+        +  +  L + +PY  M I E LR+Y P    +R   + 
Sbjct: 331 AKYPEHQQRCRDEIRELLGDGSSITWEHLSQ-MPYTTMCIKECLRLYAPVVNISRLLDKP 389

Query: 419 CEVL-GQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGP 477
                G+ +PAG  + + + ALHH+P  W  P+ FNP RF+ E  ++  P+ ++PF AG 
Sbjct: 390 ITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGL 449

Query: 478 RSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYI 529
           R+C+G    ++E K+ +   L   RF+  P+   P Q   +  L  KNG+++
Sbjct: 450 RNCIGQHFAIIECKVAV--ALTLLRFKLAPDHSRPPQPVRQVVLKSKNGIHV 499


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  112 bits (279), Expect = 1e-24
 Identities = 119/488 (24%), Positives = 204/488 (41%), Gaps = 63/488 (12%)

Query: 52  PFIGNLTFFRQGFWESQMELR---KLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNF 108
           PF+GN  FF   F +S +E++   K YG L    LG    ++I+   +IK+ L+    NF
Sbjct: 51  PFLGN--FFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNF 108

Query: 109 TNRMASGLE---FKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNE--MVPLISQACDLL 163
            NR  + +    FK   + ++    + W+E R   ++A     L +  +   I +    L
Sbjct: 109 GNRPVTPMREHIFKK--NGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHL 166

Query: 164 LAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPV---DSWQAPEDPFVKHCKRFFE- 219
              +K   E+G  FD      N  ++++ S+ FG      DSW      F +  K   E 
Sbjct: 167 TEAIKE--ENGQPFDPHFKINNAVSNIICSITFGERFEYQDSW------FQQLLKLLDEV 218

Query: 220 -FCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRD 278
            +        L   FP IM    + LP  ++   + +        + L      ++ R+D
Sbjct: 219 TYLEASKTCQLYNVFPWIM----KFLPGPHQTLFSNW------KKLKLFVSHMIDKHRKD 268

Query: 279 FLQMVLDARHSASPMGVQDF--DIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQA 336
           +           +P   +DF    ++++   TG   NP+              + ++   
Sbjct: 269 W-----------NPAETRDFIDAYLKEMSKHTG---NPTSSFHE---------ENLICST 305

Query: 337 FIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDM 396
                AG E  + TL +A   +A  P+ QEK+  E+D    +   P   +  E +PY + 
Sbjct: 306 LDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAA-RESMPYTNA 364

Query: 397 VIAETLRMYPPA-FRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPE 455
           VI E  RM         RE   D  + G  +P G ++   + ALH DP  W +P+TFNP+
Sbjct: 365 VIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPD 424

Query: 456 RFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQL 515
            F    + + R   ++PF  G R+CLG +L   E+ +    ++ KF F+     ++ L+ 
Sbjct: 425 HFLENGQFKKRE-AFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKF 483

Query: 516 ESKSALGP 523
                + P
Sbjct: 484 RMGITISP 491


>gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform b [Homo sapiens]
          Length = 511

 Score =  111 bits (278), Expect = 1e-24
 Identities = 111/470 (23%), Positives = 210/470 (44%), Gaps = 71/470 (15%)

Query: 80  GYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEF--KSVADSVLFLRDKRWEEVR 137
           G ++G   F+ I EPD  K V    +S    +     +F  + +   +L L   +W + R
Sbjct: 86  GQFIG---FLNIYEPDYAKAV----YSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHR 138

Query: 138 GALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFG 197
             L   F  + L   V + +++  ++L   +  A  G +FDI   +C+     V  +A  
Sbjct: 139 KLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI---FCD-----VGHMALN 190

Query: 198 TPVDSWQAPEDPFVKHCKRFFEFCIPRPILVL---LLSFPSIMVPLARILPNKNR----- 249
           T +       D  + H    +   +    L++   L+SF      +  + P+  R     
Sbjct: 191 TLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRAC 250

Query: 250 DELNGFFNKLIRN-VIALRDQQAAEE----RRRDFLQMVLDARHSASPMGVQDFDIVRDV 304
              +   +++IR    AL+D++  ++    R  DFL ++L AR     + + D D+  +V
Sbjct: 251 QVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDE-DDIKLSDADLRAEV 309

Query: 305 FSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDC 364
            +                                F+  G++  T+ +S+  Y +A  P+ 
Sbjct: 310 DT--------------------------------FMFEGHDTTTSGISWFLYCMALYPEH 337

Query: 365 QEKLLREVDVFKEKHMAPEFCSLEE--GLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL 422
           Q +   EV   +E     +F   ++   + YL M I E+ R+YPP  +  R+ ++    +
Sbjct: 338 QHRCREEV---REILGDQDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFV 394

Query: 423 -GQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCL 481
            G+ +PAG+++ M + ALH +   WP PE F+  RF+ E   +  PF ++PF AGPR+C+
Sbjct: 395 DGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCI 454

Query: 482 GVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKI 531
           G +  + E+K+     L +F F   P +++P+++  +  L  KNG ++ +
Sbjct: 455 GQQFAMSEMKVVTAMCLLRFEFSLDP-SRLPIKM-PQLVLRSKNGFHLHL 502


>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
           [Homo sapiens]
          Length = 520

 Score =  110 bits (276), Expect = 2e-24
 Identities = 63/209 (30%), Positives = 115/209 (55%), Gaps = 5/209 (2%)

Query: 325 RPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAPE 383
           + L+ ++I  +A  F+  G++   + LS+  Y LA +P+ QE+  +EV ++ K++     
Sbjct: 311 KKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEI 370

Query: 384 FCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL-GQRIPAGAVLEMAVGALHHD 442
                  LP+L M + E+LR++PP    +R   QD  +  G+ IP G +  ++V   HH+
Sbjct: 371 EWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHN 430

Query: 443 PEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFR 502
           P  WP PE ++P RF  E  ++  P  ++PF AGPR+C+G    + E+K+ L   L   R
Sbjct: 431 PAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVL--ALTLLR 488

Query: 503 FQACPETQVPLQLESKSALGPKNGVYIKI 531
           F+  P+   P + + +  L  + G+++++
Sbjct: 489 FRVLPDHTEP-RRKPELVLRAEGGLWLRV 516


>gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform a [Homo sapiens]
          Length = 512

 Score =  110 bits (276), Expect = 2e-24
 Identities = 111/471 (23%), Positives = 210/471 (44%), Gaps = 72/471 (15%)

Query: 80  GYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEF--KSVADSVLFLRDKRWEEVR 137
           G ++G   F+ I EPD  K V    +S    +     +F  + +   +L L   +W + R
Sbjct: 86  GQFIG---FLNIYEPDYAKAV----YSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHR 138

Query: 138 GALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFG 197
             L   F  + L   V + +++  ++L   +  A  G +FDI   +C+     V  +A  
Sbjct: 139 KLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI---FCD-----VGHMALN 190

Query: 198 TPVDSWQAPEDPFVKHCKRFFEFCIPRPILVL----LLSFPSIMVPLARILPNKNR---- 249
           T +       D  + H +    +     + +L    L+SF      +  + P+  R    
Sbjct: 191 TLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRA 250

Query: 250 -DELNGFFNKLIRN-VIALRDQQAAEE----RRRDFLQMVLDARHSASPMGVQDFDIVRD 303
               +   +++IR    AL+D++  ++    R  DFL ++L AR     + + D D+  +
Sbjct: 251 CQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDE-DDIKLSDADLRAE 309

Query: 304 VFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPD 363
           V +                                F+  G++  T+ +S+  Y +A  P+
Sbjct: 310 VDT--------------------------------FMFEGHDTTTSGISWFLYCMALYPE 337

Query: 364 CQEKLLREVDVFKEKHMAPEFCSLEE--GLPYLDMVIAETLRMYPPAFRFTREAAQDCEV 421
            Q +   EV   +E     +F   ++   + YL M I E+ R+YPP  +  R+ ++    
Sbjct: 338 HQHRCREEV---REILGDQDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF 394

Query: 422 L-GQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSC 480
           + G+ +PAG+++ M + ALH +   WP PE F+  RF+ E   +  PF ++PF AGPR+C
Sbjct: 395 VDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNC 454

Query: 481 LGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKI 531
           +G +  + E+K+     L +F F   P +++P+++  +  L  KNG ++ +
Sbjct: 455 IGQQFAMSEMKVVTAMCLLRFEFSLDP-SRLPIKM-PQLVLRSKNGFHLHL 503


>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
           [Homo sapiens]
          Length = 524

 Score =  110 bits (274), Expect = 4e-24
 Identities = 106/429 (24%), Positives = 188/429 (43%), Gaps = 48/429 (11%)

Query: 88  FIVISEPDMIKQVLVENFSNFTNRMAS-------GLEFKS--VADSVLFLRDKRWEEVRG 138
           FIV+  PD I+ +        TN  A+        + F    + + +L     +W   R 
Sbjct: 98  FIVLCHPDTIRSI--------TNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRR 149

Query: 139 ALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGT 198
            L  AF    L   + + +++ +++L   +  A  G +            D+   ++  T
Sbjct: 150 MLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSS----------RLDMFEHISLMT 199

Query: 199 PVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNK 258
            +DS Q     F  HC+        RP       + + ++ L+ ++  +++  L      
Sbjct: 200 -LDSLQKCIFSFDSHCQE-------RPS-----EYIATILELSALVEKRSQHILQHMDFL 246

Query: 259 LIRNVIALRDQQAAEERRRDFLQMVLDARHSASP-MGVQDFDIVRDVFSSTGCKPNPSRQ 317
              +    R  +A      DF   V+  R    P  G+ DF   +D   S          
Sbjct: 247 YYLSHDGRRFHRACR-LVHDFTDAVIRERRRTLPTQGIDDF--FKDKAKSKTLDFIDVLL 303

Query: 318 HQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFK 376
                  + L+ ++I  +A  F+  G++   + LS+  Y LA +P+ QE+  +EV ++ K
Sbjct: 304 LSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLK 363

Query: 377 EKHMAP-EFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL-GQRIPAGAVLEM 434
           ++     E+  L + LP+L M + E+LR++PPA   +R   QD  +  G+ IP G    +
Sbjct: 364 DRDPKEIEWDDLAQ-LPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLI 422

Query: 435 AVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTL 494
            +  +HH+P  WP PE ++P RF  E  +   P  ++PF AGPR+C+G    + E+K+ L
Sbjct: 423 DIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVL 482

Query: 495 LHVLHKFRF 503
             +L  FRF
Sbjct: 483 ALMLLHFRF 491


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  105 bits (263), Expect = 8e-23
 Identities = 127/505 (25%), Positives = 216/505 (42%), Gaps = 63/505 (12%)

Query: 16  MVTVALSVALLALLK-WYSTSAFSRLEKLGLRHPKPSPFIGN-LTFFRQGFWESQMELRK 73
           +V + L ++ L LL  W  +S   +L       P P P IGN L    +   +S   L K
Sbjct: 4   LVVLVLCLSCLLLLSLWRQSSGRGKLPP----GPTPLPVIGNILQIGIKDISKSLTNLSK 59

Query: 74  LYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGL-EFKSVADSVLFLRDKR 132
           +YGP+   Y G +  +V+   + +K+ L++    F+ R    L E  +    ++F   K+
Sbjct: 60  VYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKK 119

Query: 133 WEEVRG-ALMSA--FSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCY-CNYTT 188
           W+E+R  +LM+   F   K +    +  +A  L+    K  A   D   I  C  CN   
Sbjct: 120 WKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCN--- 176

Query: 189 DVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMV-----PLARI 243
            V+ S+ F    D     +  F+   ++  E        + +LS P I +     P+   
Sbjct: 177 -VICSIIFHKRFDY---KDQQFLNLMEKLNEN-------IKILSSPWIQICNNFSPIIDY 225

Query: 244 LPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRD 303
            P        G  NKL++NV  ++            L+ V + + S      QDF    D
Sbjct: 226 FP--------GTHNKLLKNVAFMKSY---------ILEKVKEHQESMDMNNPQDFI---D 265

Query: 304 VFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPD 363
            F     K    + +QPS      T++ +   A     AG E  + TL +A  LL  +P+
Sbjct: 266 CFLM---KMEKEKHNQPSEF----TIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPE 318

Query: 364 CQEKLLREVDVFKEKHMAPEFCSLEEG-LPYLDMVIAETLRMYPPAFRFTREAAQDCEVL 422
              K+  E++    ++ +P  C  +   +PY D V+ E  R Y      +   A  C++ 
Sbjct: 319 VTAKVQEEIERVIGRNRSP--CMQDRSHMPYTDAVVHEVQR-YIDLLPTSLPHAVTCDIK 375

Query: 423 GQR--IPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSC 480
            +   IP G  + +++ ++ HD + +P+PE F+P  F  E     +   ++PF AG R C
Sbjct: 376 FRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRIC 435

Query: 481 LGVRLGLLEVKLTLLHVLHKFRFQA 505
           +G  L  +E+ L L  +L  F  ++
Sbjct: 436 VGEALAGMELFLFLTSILQNFNLKS 460


>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  105 bits (263), Expect = 8e-23
 Identities = 61/181 (33%), Positives = 105/181 (58%), Gaps = 4/181 (2%)

Query: 325 RPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKH-MAP 382
           + L+ ++I  +A  F+  G++   + LS+  Y LA +P+ QE+  +EV ++ K++  +  
Sbjct: 311 KELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEI 370

Query: 383 EFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL-GQRIPAGAVLEMAVGALHH 441
           E+  L + LP+L M I E+LR++PP    +R   QD  +  G+ IP G V  + +  +H+
Sbjct: 371 EWDDLAQ-LPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHY 429

Query: 442 DPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKF 501
           +P  WP PE ++P RF  E  ++  P  ++PF AGPR+C+G    + E+K+ L   L  F
Sbjct: 430 NPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHF 489

Query: 502 R 502
           R
Sbjct: 490 R 490


>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  105 bits (263), Expect = 8e-23
 Identities = 61/181 (33%), Positives = 105/181 (58%), Gaps = 4/181 (2%)

Query: 325 RPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKH-MAP 382
           + L+ ++I  +A  F+  G++   + LS+  Y LA +P+ QE+  +EV ++ K++  +  
Sbjct: 311 KELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEI 370

Query: 383 EFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL-GQRIPAGAVLEMAVGALHH 441
           E+  L + LP+L M I E+LR++PP    +R   QD  +  G+ IP G V  + +  +H+
Sbjct: 371 EWDDLAQ-LPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHY 429

Query: 442 DPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKF 501
           +P  WP PE ++P RF  E  ++  P  ++PF AGPR+C+G    + E+K+ L   L  F
Sbjct: 430 NPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHF 489

Query: 502 R 502
           R
Sbjct: 490 R 490


>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 508

 Score =  105 bits (261), Expect = 1e-22
 Identities = 66/209 (31%), Positives = 104/209 (49%), Gaps = 3/209 (1%)

Query: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDV-FKEKHMAPEFC 385
           L    I+G     L+AG + ++NTLS+A Y L+ +P+ Q  L  E+         A    
Sbjct: 302 LPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSA 361

Query: 386 SLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEH 445
           ++   LP L  V+ E LR+YP     +R   +D  V    IP   ++ +   A   DP  
Sbjct: 362 TVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQ 421

Query: 446 WPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQA 505
           +P P +F P R+  E    H PF  LPFG G RSC+G RL  LE+++ L  +L  F  Q 
Sbjct: 422 FPEPNSFRPARWLGEGPTPH-PFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQP 480

Query: 506 CPETQVPLQLESKSALGPKNGVYIKIVSR 534
            P    P++ ++++ L P+  + ++ + R
Sbjct: 481 EPGA-APVRPKTRTVLVPERSINLQFLDR 508


>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 1 [Homo sapiens]
          Length = 490

 Score =  105 bits (261), Expect = 1e-22
 Identities = 120/503 (23%), Positives = 210/503 (41%), Gaps = 57/503 (11%)

Query: 15  PMVTVALSVALLALLK-WYSTSAFSRLEKLGLRHPKPSPFIGN-LTFFRQGFWESQMELR 72
           P V + L ++ L LL  W  +S   RL       P P P IGN L    +   +S     
Sbjct: 3   PAVALVLCLSCLFLLSLWRQSSGRGRLPS----GPTPLPIIGNILQLDVKDMSKSLTNFS 58

Query: 73  KLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFK-SVADSVLFLRDK 131
           K+YGP+   Y G +  +V+   + +K+ L+++   F+ R +  +  K +    +LF   K
Sbjct: 59  KVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGK 118

Query: 132 RWEEVRGALMSA---FSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCY-CNYT 187
           RW+E+R   +     F   K +    +  +A  L+    K  A   D   I  C  CN  
Sbjct: 119 RWKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCN-- 176

Query: 188 TDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFC--IPRPILVLLLSFPSIMVPLARILP 245
             V+ SV F    D +   +  F+   ++F E    +  P + +  +FP+++        
Sbjct: 177 --VICSVIFH---DRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALI-------- 223

Query: 246 NKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVF 305
               D L G  NK+  N   ++            L+ + + + S       D +  RD  
Sbjct: 224 ----DYLPGSHNKIAENFAYIKSY---------VLERIKEHQESL------DMNSARDFI 264

Query: 306 SSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQ 365
                K    + +Q S      TV+ ++        AG E  + TL +   LL   P+  
Sbjct: 265 DCFLIKMEQEKHNQQSEF----TVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVT 320

Query: 366 EKLLREVDVFKEKHMAPEFCSLEEG-LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ 424
            K+  E++    ++ +P  C  +   +PY D V+ E  R Y          A  C+V  +
Sbjct: 321 AKVQEEIECVVGRNRSP--CMQDRSHMPYTDAVVHEIQR-YIDLLPTNLPHAVTCDVKFK 377

Query: 425 R--IPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLG 482
              IP G  +  ++ ++ H+ + +P+PE F+P  F  ++    +   ++PF AG R C+G
Sbjct: 378 NYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMG 437

Query: 483 VRLGLLEVKLTLLHVLHKFRFQA 505
             L  +E+ L L  +L  F  ++
Sbjct: 438 EGLARMELFLFLTTILQNFNLKS 460


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score =  103 bits (258), Expect = 3e-22
 Identities = 115/503 (22%), Positives = 199/503 (39%), Gaps = 57/503 (11%)

Query: 15  PMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGN-LTFFRQGFWESQMELRK 73
           P V + L ++ + L   +  S   R    G   P P P IGN L    +   +S     K
Sbjct: 3   PFVVLVLCLSFMLLFSLWRQSCRRRKLPPG---PTPLPIIGNMLQIDVKDICKSFTNFSK 59

Query: 74  LYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVAD-SVLFLRDKR 132
           +YGP+   Y G    +V    + +K+ L++N   F+ R  S +  +      ++    KR
Sbjct: 60  VYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKR 119

Query: 133 WEEVRGALMSAFSPEKLNE--MVPLISQACDLLLAHLKRYAES--GDAFDIQRCYCNYTT 188
           W+E+R   ++      + +  +   + +    L+  L++   S     F +    CN   
Sbjct: 120 WKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCN--- 176

Query: 189 DVVASVAFGTPVDSWQAPEDPFVKHCKRFFEF--CIPRPILVLLLSFPSIMVPLARILPN 246
            V+ SV F    D     +  F+   KRF E    +  P + +  +FP ++         
Sbjct: 177 -VICSVVFQKRFDY---KDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLI--------- 223

Query: 247 KNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFS 306
              D   G  NK+++NV   R     + +            H AS     D +  RD   
Sbjct: 224 ---DCFPGTHNKVLKNVALTRSYIREKVKE-----------HQAS----LDVNNPRDFID 265

Query: 307 STGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQE 366
               K    + +Q S       ++ +VG      +AG E  + TL +   LL  +P+   
Sbjct: 266 CFLIKMEQEKDNQKSEF----NIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTA 321

Query: 367 KLLREVDVFKEKHMAPEFCSLEEG-LPYLDMVIAETLR---MYPPAFRFTREAAQDCEVL 422
           K+  E+D    +H +P  C  +   +PY D V+ E  R   + P           D +  
Sbjct: 322 KVQEEIDHVIGRHRSP--CMQDRSHMPYTDAVVHEIQRYSDLVPTGV--PHAVTTDTKFR 377

Query: 423 GQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLG 482
              IP G  +   + ++ HD + +P+P  F+P  F  +     +   ++PF AG R C G
Sbjct: 378 NYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAG 437

Query: 483 VRLGLLEVKLTLLHVLHKFRFQA 505
             L  +E+ L L  +L  F  ++
Sbjct: 438 EGLARMELFLFLTTILQNFNLKS 460


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.139    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,662,653
Number of Sequences: 37866
Number of extensions: 950210
Number of successful extensions: 2930
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 71
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 2724
Number of HSP's gapped (non-prelim): 103
length of query: 534
length of database: 18,247,518
effective HSP length: 107
effective length of query: 427
effective length of database: 14,195,856
effective search space: 6061630512
effective search space used: 6061630512
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.